NCI Thesaurus OBO Edition
type: Ontology
version IRI: ncit-oncotree.ttl
description: The NCIt OBO Edition project aims to increase integration of the NCIt with OBO Library ontologies. NCIt is a reference terminology that includes broad coverage of the cancer domain, including cancer related diseases, findings and abnormalities. NCIt OBO Edition releases should be considered experimental.
is version of: Thesaurus.owl
version info: 17.08d
default language: en
comment: NCI Thesaurus, a controlled vocabulary in support of NCI administrative and scientific activities. Produced by the Enterprise Vocabulary System (EVS), a project by the NCI Center for Biomedical Informatics and Information Technology. National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, U.S.A.

definition
type: AnnotationProperty
definition: English language definitions of what NCI means by the concept. These are limited to 1024 characters. They may also include information about the definition's source and attribution in a form that can easily be interpreted by software.
has exact synonym: DEFINITION

Axiom
annotated source: definition
annotated property: definition
annotated target: English language definitions of what NCI means by the concept. These are limited to 1024 characters. They may also include information about the definition's source and attribution in a form that can easily be interpreted by software.
def-source: NCI

Axiom
annotated source: definition
annotated property: has exact synonym
annotated target: DEFINITION
term-group: PT
term-source: NCI

Role_Has_Domain
type: AnnotationProperty
definition: For an NCI Thesaurus role this association specifies the role's domain kind.
code: A1
Semantic_Type: Conceptual Entity
Display_Name: Role Has Domain
Preferred_Name: Role_Has_Domain
has exact synonym: Role_Has_Domain
range: anyURI

Axiom
annotated source: Role_Has_Domain
annotated property: definition
annotated target: For an NCI Thesaurus role this association specifies the role's domain kind.
def-source: NCI

Axiom
annotated source: Role_Has_Domain
annotated property: has exact synonym
annotated target: Role_Has_Domain
term-group: PT
term-source: NCI

Has_CDRH_Parent
type: AnnotationProperty
definition: A property created to allow the source CDRH to assign a parent to each concept with the intent of creating a hierarchy that includes only terms in which they are the contributing source.
code: A10
Semantic_Type: Conceptual Entity
Display_Name: Has CDRH Parent
Preferred_Name: Has_CDRH_Parent
has exact synonym: Has_CDRH_Parent
range: anyURI

Axiom
annotated source: Has_CDRH_Parent
annotated property: definition
annotated target: A property created to allow the source CDRH to assign a parent to each concept with the intent of creating a hierarchy that includes only terms in which they are the contributing source.
def-source: NCI

Axiom
annotated source: Has_CDRH_Parent
annotated property: has exact synonym
annotated target: Has_CDRH_Parent
term-group: PT
term-source: NCI

Has_NICHD_Parent
type: AnnotationProperty
definition: A property created to allow the source NICHD to assign a parent to each concept with the intent of creating a hierarchy that includes only terms in which they are the contributing source.
code: A11
Semantic_Type: Conceptual Entity
Preferred_Name: Has_NICHD_Parent
has exact synonym: Has_NICHD_Parent
range: anyURI

Axiom
annotated source: Has_NICHD_Parent
annotated property: definition
annotated target: A property created to allow the source NICHD to assign a parent to each concept with the intent of creating a hierarchy that includes only terms in which they are the contributing source.
def-source: NCI

Axiom
annotated source: Has_NICHD_Parent
annotated property: has exact synonym
annotated target: Has_NICHD_Parent
term-group: PT
term-source: NCI

Has_Data_Element
type: AnnotationProperty
definition: An association created to relate a data element concept to the codelist term that is used to bundle its subset of valid value concepts.
code: A12
Semantic_Type: Conceptual Entity
Display_Name: Has Data Element
Preferred_Name: Has_Data_Element
has exact synonym: Has_Data_Element
range: anyURI

Axiom
annotated source: Has_Data_Element
annotated property: has exact synonym
annotated target: Has_Data_Element
term-group: PT
term-source: NCI

Axiom
annotated source: Has_Data_Element
annotated property: definition
annotated target: An association created to relate a data element concept to the codelist term that is used to bundle its subset of valid value concepts.
def-source: NCI

Related_To_Genetic_Biomarker
type: AnnotationProperty
definition: Indicates that a finding or lab test is related to a gene, possibly through a variant or product.
code: A13
Semantic_Type: Conceptual Entity
Preferred_Name: Related_To_Genetic_Biomarker
has exact synonym: Related_To_Genetic_Biomarker
range: anyURI

Axiom
annotated source: Related_To_Genetic_Biomarker
annotated property: definition
annotated target: Indicates that a finding or lab test is related to a gene, possibly through a variant or product.
def-source: NCI

Axiom
annotated source: Related_To_Genetic_Biomarker
annotated property: has exact synonym
annotated target: Related_To_Genetic_Biomarker
term-group: PT
term-source: NCI

Role_Has_Range
type: AnnotationProperty
definition: For an NCI Thesaurus role this association specifies the role's range kind.
code: A2
Semantic_Type: Conceptual Entity
Display_Name: Role Has Range
Preferred_Name: Role_Has_Range
has exact synonym: Role_Has_Range
range: anyURI

Axiom
annotated source: Role_Has_Range
annotated property: definition
annotated target: For an NCI Thesaurus role this association specifies the role's range kind.
def-source: NCI

Axiom
annotated source: Role_Has_Range
annotated property: has exact synonym
annotated target: Role_Has_Range
term-group: PT
term-source: NCI

Role_Has_Parent
type: AnnotationProperty
definition: For an NCI Thesaurus role this association specifies that the role exists as part of a role hierarchy and specifies the role's parent, the role that this role specializes.
code: A3
Semantic_Type: Conceptual Entity
Display_Name: Role Has Parent
Preferred_Name: Role_Has_Parent
has exact synonym: Role_Has_Parent
range: anyURI

Axiom
annotated source: Role_Has_Parent
annotated property: definition
annotated target: For an NCI Thesaurus role this association specifies that the role exists as part of a role hierarchy and specifies the role's parent, the role that this role specializes.
def-source: NCI

Axiom
annotated source: Role_Has_Parent
annotated property: has exact synonym
annotated target: Role_Has_Parent
term-group: PT
term-source: NCI

Qualifier_Applies_To
type: AnnotationProperty
definition: Indicates the property or association that the qualifier is to be used with.
code: A4
Semantic_Type: Conceptual Entity
Display_Name: Qualifier Applies To
Preferred_Name: Qualifier_Applies_To
has exact synonym: Qualifier_Applies_To
range: anyURI

Axiom
annotated source: Qualifier_Applies_To
annotated property: definition
annotated target: Indicates the property or association that the qualifier is to be used with.
def-source: NCI

Axiom
annotated source: Qualifier_Applies_To
annotated property: has exact synonym
annotated target: Qualifier_Applies_To
term-group: PT
term-source: NCI

Has_Salt_Form
type: AnnotationProperty
definition: Used to associate a drug with its various salt forms.
code: A5
Semantic_Type: Conceptual Entity
Display_Name: Has Salt Form
Preferred_Name: Has_Salt_Form
DesignNote: USAGE NOTE: A salt form of a drug consists of 2 parts, one acidic and one basic group that are readily disassociated in liquid phase. Salt forms are either salts of strong acids and basic drugs (e.g. Atropine Sulfate, Cetirizine Hydrochloride) or salts of strong bases and acidic drugs (Allopurinol Sodium). This association is usually used in conjunction with Has_Free_Acid_Or_Base_Form.
has exact synonym: Has_Salt_Form
range: anyURI

Axiom
annotated source: Has_Salt_Form
annotated property: definition
annotated target: Used to associate a drug with its various salt forms.
def-source: NCI

Axiom
annotated source: Has_Salt_Form
annotated property: has exact synonym
annotated target: Has_Salt_Form
term-group: PT
term-source: NCI

Has_Free_Acid_Or_Base_Form
type: AnnotationProperty
definition: Used to associate the salt form of a drug with its free acid or free base.
code: A6
Semantic_Type: Conceptual Entity
Display_Name: Has Free Acid Or Base Form
Preferred_Name: Has_Free_Acid_Or_Base_Form
DesignNote: The free acid or base is responsible for the drug's therapeutic effect. Hence, the salt form of a drug has the same mechanism of action as the free acid or base form.
has exact synonym: Has_Free_Acid_Or_Base_Form
range: anyURI

Axiom
annotated source: Has_Free_Acid_Or_Base_Form
annotated property: definition
annotated target: Used to associate the salt form of a drug with its free acid or free base.
def-source: NCI

Axiom
annotated source: Has_Free_Acid_Or_Base_Form
annotated property: has exact synonym
annotated target: Has_Free_Acid_Or_Base_Form
term-group: PT
term-source: NCI

Has_Target
type: AnnotationProperty
definition: Connects a drug or other agent to a clinically intended, molecular-scale target. The target value may be a gene, gene product, anatomic structure, biological process, or other concept, where the effect of the agent on the target is thought to be of therapeutic, diagnostic, or other clinical relevance to a disease process. The effect is most often direct, as defined at a molecular scale, but may also be indirect and/or defined at a larger scale.
code: A7
Semantic_Type: Conceptual Entity
Display_Name: Has Target
Preferred_Name: Has_Target
has exact synonym: Has_Target
range: anyURI

Axiom
annotated source: Has_Target
annotated property: definition
annotated target: Connects a drug or other agent to a clinically intended, molecular-scale target. The target value may be a gene, gene product, anatomic structure, biological process, or other concept, where the effect of the agent on the target is thought to be of therapeutic, diagnostic, or other clinical relevance to a disease process. The effect is most often direct, as defined at a molecular scale, but may also be indirect and/or defined at a larger scale.
def-source: NCI

Axiom
annotated source: Has_Target
annotated property: has exact synonym
annotated target: Has_Target
term-group: PT
term-source: NCI

Concept_In_Subset
type: AnnotationProperty
definition: Used to associate the concept defining a particular terminology subset with concepts that belong to this subset.
code: A8
Semantic_Type: Conceptual Entity
Display_Name: Concept Is In Subset
Preferred_Name: Concept_In_Subset
has exact synonym: Concept_In_Subset
range: anyURI

Axiom
annotated source: Concept_In_Subset
annotated property: definition
annotated target: Used to associate the concept defining a particular terminology subset with concepts that belong to this subset.
def-source: NCI

Axiom
annotated source: Concept_In_Subset
annotated property: has exact synonym
annotated target: Concept_In_Subset
term-group: PT
term-source: NCI

Is_Related_To_Endogenous_Product
type: AnnotationProperty
definition: An association that is asserted when there is a relationship or association between the therapeutic moiety and the endogenous gene product.
code: A9
Semantic_Type: Conceptual Entity
Display_Name: Is Related To Endogenous Product
Preferred_Name: Is_Related_To_Endogenous_Product
has exact synonym: Is_Related_To_Endogenous_Product
range: anyURI

Axiom
annotated source: Is_Related_To_Endogenous_Product
annotated property: definition
annotated target: An association that is asserted when there is a relationship or association between the therapeutic moiety and the endogenous gene product.
def-source: NCI

Axiom
annotated source: Is_Related_To_Endogenous_Product
annotated property: has exact synonym
annotated target: Is_Related_To_Endogenous_Product
term-group: PT
term-source: NCI

Definition_Review_Date
type: AnnotationProperty
code: P380
Preferred_Name: Definition_Review_Date
NCIT required: true
range: NCIT date-time-system

Definition_Reviewer_Name
type: AnnotationProperty
code: P379
Preferred_Name: Definition_Reviewer_Name
NCIT required: true
range: NCIT user-system

code
type: AnnotationProperty
read only: true
code: NHC0
Preferred_Name: code
has exact synonym: code
range: string

Axiom
annotated source: code
annotated property: has exact synonym
annotated target: code
term-group: PT

Split_From
type: AnnotationProperty
code: NHC4
Preferred_Name: Split_From
has exact synonym: Split_From
range: string

Axiom
annotated source: Split_From
annotated property: has exact synonym
annotated target: Split_From
term-group: PT

OMIM_Number
type: AnnotationProperty
definition: Indicates the accession number for a Protein or Gene within the OMIM database.
code: P100
Semantic_Type: Conceptual Entity
Display_Name: OMIM Number
Preferred_Name: OMIM_Number
has exact synonym: OMIM_Number
range: string

Axiom
annotated source: OMIM_Number
annotated property: definition
annotated target: Indicates the accession number for a Protein or Gene within the OMIM database.
def-source: NCI

Axiom
annotated source: OMIM_Number
annotated property: has exact synonym
annotated target: OMIM_Number
term-group: PT
term-source: NCI

Homologous_Gene
type: AnnotationProperty
definition: This indicates genes from other organisms that are similar in sequence and provide insight to the gene's function.
code: P101
Semantic_Type: Conceptual Entity
Display_Name: Homologous Gene
Preferred_Name: Homologous_Gene
has exact synonym: Homologous_Gene
range: string

Axiom
annotated source: Homologous_Gene
annotated property: definition
annotated target: This indicates genes from other organisms that are similar in sequence and provide insight to the gene's function.
def-source: NCI

Axiom
annotated source: Homologous_Gene
annotated property: has exact synonym
annotated target: Homologous_Gene
term-group: PT
term-source: NCI

GenBank_Accession_Number
type: AnnotationProperty
definition: Indicates the accession number for a Gene within the GenBank database.
code: P102
Semantic_Type: Conceptual Entity
Display_Name: GenBank Accession Number
Preferred_Name: GenBank_Accession_Number
has exact synonym: GenBank_Accession_Number
range: string

Axiom
annotated source: GenBank_Accession_Number
annotated property: definition
annotated target: Indicates the accession number for a Gene within the GenBank database.
def-source: NCI

Axiom
annotated source: GenBank_Accession_Number
annotated property: has exact synonym
annotated target: GenBank_Accession_Number
term-group: PT
term-source: NCI

Semantic_Type
type: AnnotationProperty
definition: The semantic type describes the sort of thing or category to which a concept belongs in the context of the UMLS semantic network.
code: P106
Semantic_Type: Conceptual Entity
Display_Name: Semantic Type
Preferred_Name: Semantic_Type
DesignNote: In general, applying semantic types aids in allowing users (or computer programs) to draw conclusions about concepts by virtue of the categories to which they have been assigned. We use a set of semantic types developed for the UMLS Metathesaurus. There are currently 134 semantic types in the UMLS.
has exact synonym: Semantic_Type
range: NCIT Semantic Type-enum

Axiom
annotated source: Semantic_Type
annotated property: definition
annotated target: The semantic type describes the sort of thing or category to which a concept belongs in the context of the UMLS semantic network.
def-source: NCI

Axiom
annotated source: Semantic_Type
annotated property: has exact synonym
annotated target: Semantic_Type
term-group: PT
term-source: NCI

Display_Name
type: AnnotationProperty
definition: Provides an alternative Preferred Name for use in some NCI systems.
code: P107
Semantic_Type: Conceptual Entity
Display_Name: Display Name
Preferred_Name: Display_Name
has exact synonym: Display Name
has exact synonym: Display_Name
range: string

Axiom
annotated source: Display_Name
annotated property: definition
annotated target: Provides an alternative Preferred Name for use in some NCI systems.
def-source: NCI

Axiom
annotated source: Display_Name
annotated property: has exact synonym
annotated target: Display Name
term-group: SY
term-source: NCI

Axiom
annotated source: Display_Name
annotated property: has exact synonym
annotated target: Display_Name
term-group: PT
term-source: NCI

Preferred_Name
type: AnnotationProperty
definition: The word or phrase that NCI uses by preference to refer to the concept.
code: P108
Semantic_Type: Conceptual Entity
Display_Name: Preferred Name
Preferred_Name: Preferred_Name
has exact synonym: Preferred Name
has exact synonym: Preferred Term
has exact synonym: Preferred_Name
range: string

Axiom
annotated source: Preferred_Name
annotated property: definition
annotated target: The word or phrase that NCI uses by preference to refer to the concept.
def-source: NCI

Axiom
annotated source: Preferred_Name
annotated property: has exact synonym
annotated target: Preferred Name
term-group: SY
term-source: NCI

Axiom
annotated source: Preferred_Name
annotated property: has exact synonym
annotated target: Preferred Term
term-group: SY
term-source: NCI

Axiom
annotated source: Preferred_Name
annotated property: has exact synonym
annotated target: Preferred_Name
term-group: PT
term-source: NCI

Image_Link
type: AnnotationProperty
definition: Provides a link to an image in an external database.
code: P167
Semantic_Type: Conceptual Entity
Display_Name: Image Link
Preferred_Name: Image_Link
has exact synonym: Image_Link
range: string

Axiom
annotated source: Image_Link
annotated property: definition
annotated target: Provides a link to an image in an external database.
def-source: NCI

Axiom
annotated source: Image_Link
annotated property: has exact synonym
annotated target: Image_Link
term-group: PT
term-source: NCI

PubMedID_Primary_Reference
type: AnnotationProperty
definition: Used by the MMHCC vocabulary to provide a primary reference for descriptions of mouse diseases.
code: P171
Semantic_Type: Conceptual Entity
Display_Name: PubMedID Primary Reference
Preferred_Name: PubMedID_Primary_Reference
has exact synonym: PubMedID_Primary_Reference
range: string

Axiom
annotated source: PubMedID_Primary_Reference
annotated property: definition
annotated target: Used by the MMHCC vocabulary to provide a primary reference for descriptions of mouse diseases.
def-source: NCI

Axiom
annotated source: PubMedID_Primary_Reference
annotated property: has exact synonym
annotated target: PubMedID_Primary_Reference
term-group: PT
term-source: NCI

NSC_Code
type: AnnotationProperty
definition: A numeric identifier for substances submitted to the National Cancer Institute (NCI) for testing and evaluation. It is named after the Cancer Chemotherapy National Service Center (CCNSC), created in 1955, which originally ran the testing program and assigned these numbers. The testing program and repository is now run by the NCI Developmental Therapeutics Program (DTP). Assignment of NSC numbers was never done in a way that would guarantee one and only one NSC number would be assigned to a particular substance.
code: P175
Semantic_Type: Conceptual Entity
Display_Name: NSC Number
Preferred_Name: NSC_Number
has exact synonym: NSC_Code
has exact synonym: NSC_Number
has exact synonym: NSC_Number_Property
range: string

Axiom
annotated source: NSC_Code
annotated property: definition
annotated target: A numeric identifier for substances submitted to the National Cancer Institute (NCI) for testing and evaluation. It is named after the Cancer Chemotherapy National Service Center (CCNSC), created in 1955, which originally ran the testing program and assigned these numbers. The testing program and repository is now run by the NCI Developmental Therapeutics Program (DTP). Assignment of NSC numbers was never done in a way that would guarantee one and only one NSC number would be assigned to a particular substance.
def-source: NCI

Axiom
annotated source: NSC_Code
annotated property: has exact synonym
annotated target: NSC_Code
term-group: SY
term-source: NCI

Axiom
annotated source: NSC_Code
annotated property: has exact synonym
annotated target: NSC_Number
term-group: PT
term-source: NCI

Axiom
annotated source: NSC_Code
annotated property: has exact synonym
annotated target: NSC_Number_Property
term-group: SY
term-source: NCI

OLD_PARENT
type: AnnotationProperty
definition: Used to store the name of parent concepts present at the time a concept was retired.
code: P200
Semantic_Type: Conceptual Entity
Display_Name: OLD PARENT
Preferred_Name: OLD_PARENT
has exact synonym: OLD_PARENT
range: string

Axiom
annotated source: OLD_PARENT
annotated property: definition
annotated target: Used to store the name of parent concepts present at the time a concept was retired.
def-source: NCI

Axiom
annotated source: OLD_PARENT
annotated property: has exact synonym
annotated target: OLD_PARENT
term-group: PT
term-source: NCI

OLD_CHILD
type: AnnotationProperty
definition: Used to store the name of children concepts present at the time a concept was retired.
code: P201
Semantic_Type: Conceptual Entity
Display_Name: OLD CHILD
Preferred_Name: OLD_CHILD
has exact synonym: OLD_CHILD
range: string

Axiom
annotated source: OLD_CHILD
annotated property: definition
annotated target: Used to store the name of children concepts present at the time a concept was retired.
def-source: NCI

Axiom
annotated source: OLD_CHILD
annotated property: has exact synonym
annotated target: OLD_CHILD
term-group: PT
term-source: NCI

OLD_KIND
type: AnnotationProperty
definition: Used to store the name of the concept's kind at the time a concept was retired.
code: P203
Semantic_Type: Conceptual Entity
Display_Name: OLD KIND
Preferred_Name: OLD_KIND
has exact synonym: OLD_KIND
range: string

Axiom
annotated source: OLD_KIND
annotated property: definition
annotated target: Used to store the name of the concept's kind at the time a concept was retired.
def-source: NCI

Axiom
annotated source: OLD_KIND
annotated property: has exact synonym
annotated target: OLD_KIND
term-group: PT
term-source: NCI

OLD_ROLE
type: AnnotationProperty
definition: Used to store the name and value of asserted roles present at the time a concept was retired.
code: P204
Semantic_Type: Conceptual Entity
Display_Name: OLD ROLE
Preferred_Name: OLD_ROLE
has exact synonym: OLD_ROLE
range: string

Axiom
annotated source: OLD_ROLE
annotated property: definition
annotated target: Used to store the name and value of asserted roles present at the time a concept was retired.
def-source: NCI

Axiom
annotated source: OLD_ROLE
annotated property: has exact synonym
annotated target: OLD_ROLE
term-group: PT
term-source: NCI

OLD_STATE
type: AnnotationProperty
definition: Used to store the state of a concept, primitive or defined, at the time a concept was retired.
code: P205
Semantic_Type: Conceptual Entity
Display_Name: OLD STATE
Preferred_Name: OLD_STATE
has exact synonym: OLD_STATE
range: string

Axiom
annotated source: OLD_STATE
annotated property: definition
annotated target: Used to store the state of a concept, primitive or defined, at the time a concept was retired.
def-source: NCI

Axiom
annotated source: OLD_STATE
annotated property: has exact synonym
annotated target: OLD_STATE
term-group: PT
term-source: NCI

UMLS_CUI
type: AnnotationProperty
definition: Concept Unique Identifiers, or CUIs, are concept numbers assigned by the National Library of Medicine (NLM). If a concept in any NCI-maintained knowledgebase exists in the NLM Unified Medical Language System (UMLS), NCI includes the NLM CUI among the information we provide about the concept.
code: P207
Semantic_Type: Conceptual Entity
Display_Name: UMLS CUI
Preferred_Name: UMLS_CUI
has exact synonym: UMLS_CUI
range: string

Axiom
annotated source: UMLS_CUI
annotated property: definition
annotated target: Concept Unique Identifiers, or CUIs, are concept numbers assigned by the National Library of Medicine (NLM). If a concept in any NCI-maintained knowledgebase exists in the NLM Unified Medical Language System (UMLS), NCI includes the NLM CUI among the information we provide about the concept.
def-source: NCI

Axiom
annotated source: UMLS_CUI
annotated property: has exact synonym
annotated target: UMLS_CUI
term-group: PT
term-source: NCI

NCI_META_CUI
type: AnnotationProperty
definition: Contains a Concept Unique Identifier for those concepts that appear in NCI Metathesaurus but not in the NLM UMLS.
code: P208
Semantic_Type: Conceptual Entity
Display_Name: NCI Metathesaurus CUI
Preferred_Name: NCI_META_CUI
has exact synonym: NCI_META_CUI
range: string

Axiom
annotated source: NCI_META_CUI
annotated property: definition
annotated target: Contains a Concept Unique Identifier for those concepts that appear in NCI Metathesaurus but not in the NLM UMLS.
def-source: NCI

Axiom
annotated source: NCI_META_CUI
annotated property: has exact synonym
annotated target: NCI_META_CUI
term-group: PT
term-source: NCI

CAS_Registry
type: AnnotationProperty
definition: Indicates the Chemical Abstracts Service number for a Chemical or Drug.
code: P210
Semantic_Type: Conceptual Entity
Display_Name: CAS Registry Number
Preferred_Name: CAS_Registry
has exact synonym: CAS_Registry
range: string

Axiom
annotated source: CAS_Registry
annotated property: definition
annotated target: Indicates the Chemical Abstracts Service number for a Chemical or Drug.
def-source: NCI

Axiom
annotated source: CAS_Registry
annotated property: has exact synonym
annotated target: CAS_Registry
term-group: PT
term-source: NCI

GO_Annotation
type: AnnotationProperty
definition: Contains information that can be used for cross-referencing to relevant entries in the Gene Ontology database including term name, code, and evidence code.
code: P211
Semantic_Type: Conceptual Entity
Display_Name: GO Annotation
Preferred_Name: GO_Annotation
has exact synonym: GO_Annotation
range: NCIT textArea

Axiom
annotated source: GO_Annotation
annotated property: definition
annotated target: Contains information that can be used for cross-referencing to relevant entries in the Gene Ontology database including term name, code, and evidence code.
def-source: NCI

Axiom
annotated source: GO_Annotation
annotated property: has exact synonym
annotated target: GO_Annotation
term-group: PT
term-source: NCI

KEGG_ID
type: AnnotationProperty
definition: Indicates the KEGG ID code for a pathway. It can be used to link a KEGG pathway reference to the primary pathway information.
code: P215
Semantic_Type: Conceptual Entity
Display_Name: KEGG ID
Preferred_Name: KEGG_ID
has exact synonym: KEGG_ID
range: string

Axiom
annotated source: KEGG_ID
annotated property: definition
annotated target: Indicates the KEGG ID code for a pathway. It can be used to link a KEGG pathway reference to the primary pathway information.
def-source: NCI

Axiom
annotated source: KEGG_ID
annotated property: has exact synonym
annotated target: KEGG_ID
term-group: PT
term-source: NCI

BioCarta_ID
type: AnnotationProperty
definition: Indicates the BioCarta ID code for a pathway. It can be used to link a BioCarta pathway reference to the primary pathway information.
code: P216
Semantic_Type: Conceptual Entity
Display_Name: BioCarta ID
Preferred_Name: BioCarta_ID
has exact synonym: BioCarta_ID
range: string

Axiom
annotated source: BioCarta_ID
annotated property: definition
annotated target: Indicates the BioCarta ID code for a pathway. It can be used to link a BioCarta pathway reference to the primary pathway information.
def-source: NCI

Axiom
annotated source: BioCarta_ID
annotated property: has exact synonym
annotated target: BioCarta_ID
term-group: PT
term-source: NCI

Accepted_Therapeutic_Use_For
type: AnnotationProperty
definition: Indicates a disease or condition for which this drug is an accepted treatment. Used in Chemicals and Drug Kind.
code: P302
Semantic_Type: Conceptual Entity
Display_Name: Accepted Therapeutic Use For
Preferred_Name: Accepted_Therapeutic_Use_For
has exact synonym: Accepted_Therapeutic_Use_For
range: string

Axiom
annotated source: Accepted_Therapeutic_Use_For
annotated property: definition
annotated target: Indicates a disease or condition for which this drug is an accepted treatment. Used in Chemicals and Drug Kind.
def-source: NCI

Axiom
annotated source: Accepted_Therapeutic_Use_For
annotated property: has exact synonym
annotated target: Accepted_Therapeutic_Use_For
term-group: PT
term-source: NCI

Concept_Status
type: AnnotationProperty
definition: An NCI Thesaurus property used to indicate the standing of a concept in relation to currently accepted classifications and concepts. In NCI Thesaurus concept status subtype indicates concepts with unusual and problematic characteristics that should be evaluated by people and/or programs before those concept are used.
code: P310
Semantic_Type: Conceptual Entity
Display_Name: Concept Status
Preferred_Name: Concept_Status
has exact synonym: Concept_Status
range: NCIT Concept Status-enum

Axiom
annotated source: Concept_Status
annotated property: definition
annotated target: An NCI Thesaurus property used to indicate the standing of a concept in relation to currently accepted classifications and concepts. In NCI Thesaurus concept status subtype indicates concepts with unusual and problematic characteristics that should be evaluated by people and/or programs before those concept are used.
def-source: NCI

Axiom
annotated source: Concept_Status
annotated property: has exact synonym
annotated target: Concept_Status
term-group: PT
term-source: NCI

SNP_ID
type: AnnotationProperty
definition: Indicates the dbSNP id number for the genetic polymorphism due to base substitutions.
code: P315
Semantic_Type: Conceptual Entity
Display_Name: SNP ID
Preferred_Name: SNP_ID
has exact synonym: SNP_ID
range: string

Axiom
annotated source: SNP_ID
annotated property: definition
annotated target: Indicates the dbSNP id number for the genetic polymorphism due to base substitutions.
def-source: NCI

Axiom
annotated source: SNP_ID
annotated property: has exact synonym
annotated target: SNP_ID
term-group: PT
term-source: NCI

Relative_Enzyme_Activity
type: AnnotationProperty
definition: Indicates drug efficacy of the allelic product.
code: P316
Semantic_Type: Conceptual Entity
Display_Name: Relative Enzyme Activity
Preferred_Name: Relative_Enzyme_Activity
has exact synonym: Relative_Enzyme_Activity
range: string

Axiom
annotated source: Relative_Enzyme_Activity
annotated property: definition
annotated target: Indicates drug efficacy of the allelic product.
def-source: NCI

Axiom
annotated source: Relative_Enzyme_Activity
annotated property: has exact synonym
annotated target: Relative_Enzyme_Activity
term-group: PT
term-source: NCI

FDA_Table
type: AnnotationProperty
definition: Used to flag terms that are part of an FDA data standard manual, including Route of Administration, Dosage Form, Package Type and Potency.
code: P317
Semantic_Type: Conceptual Entity
Display_Name: FDA Table
Preferred_Name: FDA_Table
has exact synonym: FDA_Table
range: NCIT FDA Table-enum

Axiom
annotated source: FDA_Table
annotated property: definition
annotated target: Used to flag terms that are part of an FDA data standard manual, including Route of Administration, Dosage Form, Package Type and Potency.
def-source: NCI

Axiom
annotated source: FDA_Table
annotated property: has exact synonym
annotated target: FDA_Table
term-group: PT
term-source: NCI

FDA_UNII_Code
type: AnnotationProperty
definition: Contains the FDA Unique Ingredient Identifier, a key component of the new federal drug information model.
code: P319
Semantic_Type: Conceptual Entity
Display_Name: FDA UNII Code
Preferred_Name: FDA_UNII_Code
has exact synonym: FDA_UNII_Code
range: string

Axiom
annotated source: FDA_UNII_Code
annotated property: definition
annotated target: Contains the FDA Unique Ingredient Identifier, a key component of the new federal drug information model.
def-source: NCI

Axiom
annotated source: FDA_UNII_Code
annotated property: has exact synonym
annotated target: FDA_UNII_Code
term-group: PT
term-source: NCI

OID
type: AnnotationProperty
code: P320
Semantic_Type: Conceptual Entity
Display_Name: OID
Preferred_Name: OID
has exact synonym: OID
range: string

Axiom
annotated source: OID
annotated property: has exact synonym
annotated target: OID
term-group: PT
term-source: NCI

EntrezGene_ID
type: AnnotationProperty
definition: Indicates the accession number for a Protein or Gene within the Entrez Gene database.
code: P321
Semantic_Type: Conceptual Entity
Display_Name: EntrezGene ID
Preferred_Name: EntrezGene_ID
DesignNote: This property has replaced Locus_ID.
has exact synonym: EntrezGene_ID
has exact synonym: GeneID
has exact synonym: Locus_ID
range: string

Axiom
annotated source: EntrezGene_ID
annotated property: definition
annotated target: Indicates the accession number for a Protein or Gene within the Entrez Gene database.
def-source: NCI

Axiom
annotated source: EntrezGene_ID
annotated property: has exact synonym
annotated target: EntrezGene_ID
term-group: PT
term-source: NCI

Axiom
annotated source: EntrezGene_ID
annotated property: has exact synonym
annotated target: GeneID
term-group: SY
term-source: NCI

Axiom
annotated source: EntrezGene_ID
annotated property: has exact synonym
annotated target: Locus_ID
term-group: SY
term-source: NCI

Contributing_Source
type: AnnotationProperty
definition: This property is used to indicate when a non-EVS entity has contributed to, and has a stake in, a concept. This is used where such entities, within or outside NCI, have indicated the need to be able to track their own concepts. A single concept can have multiple instances of this property if multiple entities have such a defined stake.
code: P322
Semantic_Type: Conceptual Entity
Display_Name: Contributing Source
Preferred_Name: Contributing_Source
has exact synonym: Contributing_Source
range: NCIT Contributing Source-enum

Axiom
annotated source: Contributing_Source
annotated property: definition
annotated target: This property is used to indicate when a non-EVS entity has contributed to, and has a stake in, a concept. This is used where such entities, within or outside NCI, have indicated the need to be able to track their own concepts. A single concept can have multiple instances of this property if multiple entities have such a defined stake.
def-source: NCI

Axiom
annotated source: Contributing_Source
annotated property: has exact synonym
annotated target: Contributing_Source
term-group: PT
term-source: NCI

ALT_DEFINITION
type: AnnotationProperty
definition: English language definitions of what a source other than NCI means by the concept. These are limited to 1024 characters. They include information about the definition's source in a form that can easily be interpreted by software.
code: P325
Semantic_Type: Conceptual Entity
Display_Name: [source] Definition
Preferred_Name: ALT_DEFINITION
has exact synonym: ALT_DEFINITION
range: NCIT textArea

Axiom
annotated source: ALT_DEFINITION
annotated property: definition
annotated target: English language definitions of what a source other than NCI means by the concept. These are limited to 1024 characters. They include information about the definition's source in a form that can easily be interpreted by software.
def-source: NCI

Axiom
annotated source: ALT_DEFINITION
annotated property: has exact synonym
annotated target: ALT_DEFINITION
term-group: PT
term-source: NCI

PDQ_Open_Trial_Search_ID
type: AnnotationProperty
definition: The identifier used by NCI's Cancer.gov Web site to retrieve PDQ Clinical Trials data for open trials involving specific clinical trials agents. While the identifier is the same for both open and closed trials two properties are used to support requirements of the current browser interface, as well as the possibility of providing values only where trials will be retrieved.
code: P329
Semantic_Type: Conceptual Entity
Display_Name: PDQ Open Trial Search ID
Preferred_Name: PDQ_Open_Trial_Search_ID
has exact synonym: PDQ_Open_Trial_Search_ID
range: string

Axiom
annotated source: PDQ_Open_Trial_Search_ID
annotated property: definition
annotated target: The identifier used by NCI's Cancer.gov Web site to retrieve PDQ Clinical Trials data for open trials involving specific clinical trials agents. While the identifier is the same for both open and closed trials two properties are used to support requirements of the current browser interface, as well as the possibility of providing values only where trials will be retrieved.
def-source: NCI

Axiom
annotated source: PDQ_Open_Trial_Search_ID
annotated property: has exact synonym
annotated target: PDQ_Open_Trial_Search_ID
term-group: PT
term-source: NCI

PDQ_Closed_Trial_Search_ID
type: AnnotationProperty
definition: The identifier used by NCI's Cancer.gov web site to retrieve PDQ Clinical Trials data for closed trials that involved specific clinical trials agents. While the identifier is the same for both open and closed trials two properties are used to support requirements of the current browser interface, as well as the possibility of providing values only where trials will be retrieved.
code: P330
Semantic_Type: Conceptual Entity
Display_Name: PDQ Closed Trial Search ID
Preferred_Name: PDQ_Closed_Trial_Search_ID
has exact synonym: PDQ_Closed_Trial_Search_ID
range: string

Axiom
annotated source: PDQ_Closed_Trial_Search_ID
annotated property: has exact synonym
annotated target: PDQ_Closed_Trial_Search_ID
term-group: PT
term-source: NCI

Axiom
annotated source: PDQ_Closed_Trial_Search_ID
annotated property: definition
annotated target: The identifier used by NCI's Cancer.gov web site to retrieve PDQ Clinical Trials data for closed trials that involved specific clinical trials agents. While the identifier is the same for both open and closed trials two properties are used to support requirements of the current browser interface, as well as the possibility of providing values only where trials will be retrieved.
def-source: NCI

NCBI_Taxon_ID
type: AnnotationProperty
definition: The NCBI_Taxon_ID property is used to establish correspondence between the NCI Thesaurus concept representing a taxon (species) and the NCBI/NLM Species Taxonomy ID assigned by the NCBI to that taxon.
code: P331
Semantic_Type: Conceptual Entity
Display_Name: NCBI Taxon ID
Preferred_Name: NCBI_Taxon_ID
has exact synonym: NCBI_Taxon_ID
range: string

Axiom
annotated source: NCBI_Taxon_ID
annotated property: definition
annotated target: The NCBI_Taxon_ID property is used to establish correspondence between the NCI Thesaurus concept representing a taxon (species) and the NCBI/NLM Species Taxonomy ID assigned by the NCBI to that taxon.
def-source: NCI

Axiom
annotated source: NCBI_Taxon_ID
annotated property: has exact synonym
annotated target: NCBI_Taxon_ID
term-group: PT
term-source: NCI

MGI_Accession_ID
type: AnnotationProperty
definition: The identifier used by Jackson Laboratories Mouse Genome Informatics group to label inbred mouse strains maintained by Jackson Laboratory and other things such as mouse genes and alleles.
code: P332
Semantic_Type: Conceptual Entity
Display_Name: MGI Accession ID
Preferred_Name: MGI_Accession_ID
has exact synonym: MGI_Accession_ID
range: string

Axiom
annotated source: MGI_Accession_ID
annotated property: definition
annotated target: The identifier used by Jackson Laboratories Mouse Genome Informatics group to label inbred mouse strains maintained by Jackson Laboratory and other things such as mouse genes and alleles.
def-source: NCI

Axiom
annotated source: MGI_Accession_ID
annotated property: has exact synonym
annotated target: MGI_Accession_ID
term-group: PT
term-source: NCI

Use_For
type: AnnotationProperty
definition: Indicates a term that had been used in a coding system and then subsumed by the given NCIt concept.
code: P333
Semantic_Type: Conceptual Entity
Display_Name: Use For
Preferred_Name: Use_For
has exact synonym: Use_For
range: string

Axiom
annotated source: Use_For
annotated property: definition
annotated target: Indicates a term that had been used in a coding system and then subsumed by the given NCIt concept.
def-source: NCI

Axiom
annotated source: Use_For
annotated property: has exact synonym
annotated target: Use_For
term-group: PT
term-source: NCI

ICD-O-3_Code
type: AnnotationProperty
definition: Indicates the matching ICD-O-3 code for the NCI Thesaurus concept.
code: P334
Semantic_Type: Conceptual Entity
Display_Name: ICD-O-3 Code
Preferred_Name: ICD-O-3_Code
has exact synonym: ICD-O-3_Code
range: string

Axiom
annotated source: ICD-O-3_Code
annotated property: definition
annotated target: Indicates the matching ICD-O-3 code for the NCI Thesaurus concept.
def-source: NCI

Axiom
annotated source: ICD-O-3_Code
annotated property: has exact synonym
annotated target: ICD-O-3_Code
term-group: PT
term-source: NCI

Chemical_Formula
type: AnnotationProperty
definition: Concise expression about the atoms that constitute a particular chemical compound.
code: P350
Semantic_Type: Conceptual Entity
Display_Name: Chemical Formula
Preferred_Name: Chemical_Formula
Contributing_Source: CRCH
has exact synonym: Chemical Formula
has exact synonym: Chemical_Formula
range: string

Axiom
annotated source: Chemical_Formula
annotated property: definition
annotated target: Concise expression about the atoms that constitute a particular chemical compound.
def-source: NCI

Axiom
annotated source: Chemical_Formula
annotated property: has exact synonym
annotated target: Chemical Formula
term-group: PT
term-source: CRCH

Axiom
annotated source: Chemical_Formula
annotated property: has exact synonym
annotated target: Chemical_Formula
term-group: PT
term-source: NCI

US_Recommended_Intake
type: AnnotationProperty
code: P351
Semantic_Type: Conceptual Entity
Display_Name: US FNB Recommends Intake
Preferred_Name: US_Recommended_Intake
Contributing_Source: CRCH
ALT_DEFINITION: A property indicating that the Food and Nutrition Board of the National Academy of Science has established an average daily intake for this nutrient that is sufficient to meet the nutritional requirements of most individuals in the general U.S. population.
has exact synonym: Recommended Intake
has exact synonym: Required_Intake
has exact synonym: US_Recommended_Intake
range: string

Axiom
annotated source: US_Recommended_Intake
annotated property: ALT_DEFINITION
annotated target: A property indicating that the Food and Nutrition Board of the National Academy of Science has established an average daily intake for this nutrient that is sufficient to meet the nutritional requirements of most individuals in the general U.S. population.
def-source: CRCH

Axiom
annotated source: US_Recommended_Intake
annotated property: has exact synonym
annotated target: Recommended Intake
term-group: PT
term-source: CRCH

Axiom
annotated source: US_Recommended_Intake
annotated property: has exact synonym
annotated target: Required_Intake
term-group: SY
term-source: NCI

Axiom
annotated source: US_Recommended_Intake
annotated property: has exact synonym
annotated target: US_Recommended_Intake
term-group: PT
term-source: NCI

Tolerable_Level
type: AnnotationProperty
code: P352
Semantic_Type: Conceptual Entity
Display_Name: Tolerable Level
Preferred_Name: Tolerable_Level
Contributing_Source: CRCH
ALT_DEFINITION: A property indicating that the Food and Nutrition Board of the National Academy of Science has established a highest level of daily intake for this food component that is likely to pose no risk of adverse health effects for almost all individuals in the general U.S. population.
has exact synonym: Tolerable Level
has exact synonym: Tolerable_Level
range: string

Axiom
annotated source: Tolerable_Level
annotated property: ALT_DEFINITION
annotated target: A property indicating that the Food and Nutrition Board of the National Academy of Science has established a highest level of daily intake for this food component that is likely to pose no risk of adverse health effects for almost all individuals in the general U.S. population.
def-source: CRCH

Axiom
annotated source: Tolerable_Level
annotated property: has exact synonym
annotated target: Tolerable Level
term-group: PT
term-source: CRCH

Axiom
annotated source: Tolerable_Level
annotated property: has exact synonym
annotated target: Tolerable_Level
term-group: PT
term-source: NCI

INFOODS
type: AnnotationProperty
definition: Uppercase abbreviations assigned by the International Network of Food Data Systems.
code: P353
Semantic_Type: Conceptual Entity
Display_Name: INFOODS Tag Name
Preferred_Name: INFOODS
Contributing_Source: CRCH
has exact synonym: INFOODS
range: string

Axiom
annotated source: INFOODS
annotated property: definition
annotated target: Uppercase abbreviations assigned by the International Network of Food Data Systems.
def-source: NCI

Axiom
annotated source: INFOODS
annotated property: has exact synonym
annotated target: INFOODS
term-group: PT
term-source: CRCH

Axiom
annotated source: INFOODS
annotated property: has exact synonym
annotated target: INFOODS
term-group: PT
term-source: NCI

USDA_ID
type: AnnotationProperty
definition: Numeric ID assignment by United States Department of Agriculture.
code: P354
Semantic_Type: Conceptual Entity
Display_Name: USDA ID
Preferred_Name: USDA_ID
Contributing_Source: CRCH
has exact synonym: USDA ID
has exact synonym: USDA_ID
range: string

Axiom
annotated source: USDA_ID
annotated property: definition
annotated target: Numeric ID assignment by United States Department of Agriculture.
def-source: NCI

Axiom
annotated source: USDA_ID
annotated property: has exact synonym
annotated target: USDA ID
term-group: PT
term-source: CRCH

Axiom
annotated source: USDA_ID
annotated property: has exact synonym
annotated target: USDA_ID
term-group: PT
term-source: NCI

Unit
type: AnnotationProperty
definition: the unit of measure in which a nutrient or food component is typically expressed, ex., gram (g), minigram (mg), microgram (mcg), joule, or kilojoule.
code: P355
Semantic_Type: Conceptual Entity
Display_Name: Unit Used
Preferred_Name: Unit
Contributing_Source: CRCH
has exact synonym: Unit
range: string

Axiom
annotated source: Unit
annotated property: definition
annotated target: the unit of measure in which a nutrient or food component is typically expressed, ex., gram (g), minigram (mg), microgram (mcg), joule, or kilojoule.
def-source: NCI

Axiom
annotated source: Unit
annotated property: has exact synonym
annotated target: Unit
term-group: PT
term-source: CRCH

Axiom
annotated source: Unit
annotated property: has exact synonym
annotated target: Unit
term-group: PT
term-source: NCI

Essential_Amino_Acid
type: AnnotationProperty
definition: Property used to indicate that an amino acid is essential and must be included in the diet.
code: P356
Semantic_Type: Conceptual Entity
Display_Name: Is An Essential Amino Acid
Preferred_Name: Essential_Amino_Acid
has exact synonym: Essential_Amino_Acid
range: string

Axiom
annotated source: Essential_Amino_Acid
annotated property: definition
annotated target: Property used to indicate that an amino acid is essential and must be included in the diet.
def-source: NCI

Axiom
annotated source: Essential_Amino_Acid
annotated property: has exact synonym
annotated target: Essential_Amino_Acid
term-group: PT
term-source: NCI

Essential_Fatty_Acid
type: AnnotationProperty
definition: Used to indicate a fatty acid that is not efficiently synthesized by humans and must be included in the diet.
code: P357
Semantic_Type: Conceptual Entity
Display_Name: Is An Essential Fatty Acid
Preferred_Name: Essential_Fatty_Acid
Contributing_Source: CRCH
has exact synonym: Essential Fatty Acid
has exact synonym: Essential_Fatty_Acid
range: string

Axiom
annotated source: Essential_Fatty_Acid
annotated property: definition
annotated target: Used to indicate a fatty acid that is not efficiently synthesized by humans and must be included in the diet.
def-source: NCI

Axiom
annotated source: Essential_Fatty_Acid
annotated property: has exact synonym
annotated target: Essential Fatty Acid
term-group: PT
term-source: CRCH

Axiom
annotated source: Essential_Fatty_Acid
annotated property: has exact synonym
annotated target: Essential_Fatty_Acid
term-group: PT
term-source: NCI

Nutrient
type: AnnotationProperty
code: P358
Semantic_Type: Conceptual Entity
Display_Name: Is A Nutrient
Preferred_Name: Nutrient
Contributing_Source: CRCH
ALT_DEFINITION: A property indicating that a food component must be taken into the body preformed and in sufficient quantity to meet the body's needs for growth, reproduction and/or maintenance of health.
has exact synonym: Nutrient
range: string

Axiom
annotated source: Nutrient
annotated property: ALT_DEFINITION
annotated target: A property indicating that a food component must be taken into the body preformed and in sufficient quantity to meet the body's needs for growth, reproduction and/or maintenance of health.
def-source: CRCH

Axiom
annotated source: Nutrient
annotated property: has exact synonym
annotated target: Nutrient
term-group: PT
term-source: CRCH

Axiom
annotated source: Nutrient
annotated property: has exact synonym
annotated target: Nutrient
term-group: PT
term-source: NCI

Micronutrient
type: AnnotationProperty
code: P359
Semantic_Type: Conceptual Entity
Display_Name: Is A Micronutrient
Preferred_Name: Micronutrient
Contributing_Source: CRCH
ALT_DEFINITION: A property indicating a class of food components required for proper health and that are typically consumed in microgram or milligram amounts.
Unit: mg
has exact synonym: Micronutrient
range: string

Axiom
annotated source: Micronutrient
annotated property: ALT_DEFINITION
annotated target: A property indicating a class of food components required for proper health and that are typically consumed in microgram or milligram amounts.
def-source: CRCH

Axiom
annotated source: Micronutrient
annotated property: has exact synonym
annotated target: Micronutrient
term-group: PT
term-source: CRCH

Axiom
annotated source: Micronutrient
annotated property: has exact synonym
annotated target: Micronutrient
term-group: PT
term-source: NCI

Macronutrient
type: AnnotationProperty
code: P360
Semantic_Type: Conceptual Entity
Display_Name: Macronutrient
Preferred_Name: Macronutrient
Contributing_Source: CRCH
ALT_DEFINITION: A property indicating a class of food components that contribute energy to the diet and that are typically consumed in multi-gram amounts.
Unit: g
has exact synonym: Macronutrient
range: string

Axiom
annotated source: Macronutrient
annotated property: ALT_DEFINITION
annotated target: A property indicating a class of food components that contribute energy to the diet and that are typically consumed in multi-gram amounts.
def-source: CRCH

Axiom
annotated source: Macronutrient
annotated property: has exact synonym
annotated target: Macronutrient
term-group: PT
term-source: CRCH

Axiom
annotated source: Macronutrient
annotated property: has exact synonym
annotated target: Macronutrient
term-group: PT
term-source: NCI

Extensible_List
type: AnnotationProperty
definition: Describes the ability to extend the set of values in a particular list.
code: P361
Semantic_Type: Conceptual Entity
Preferred_Name: Extensible_List
has exact synonym: Extensible_List
has exact synonym: List Extensible
range: NCIT Extensible List-enum

Axiom
annotated source: Extensible_List
annotated property: definition
annotated target: Describes the ability to extend the set of values in a particular list.
def-source: NCI

Axiom
annotated source: Extensible_List
annotated property: has exact synonym
annotated target: Extensible_List
term-group: PT
term-source: NCI

Axiom
annotated source: Extensible_List
annotated property: has exact synonym
annotated target: List Extensible
term-group: SY
term-source: NCI

miRBase_ID
type: AnnotationProperty
definition: Indicates the accession number for an miRNA within the Sanger miRBase database.
code: P362
Semantic_Type: Conceptual Entity
Preferred_Name: miRBase_ID
has exact synonym: miRBase_ID
range: string

Axiom
annotated source: miRBase_ID
annotated property: definition
annotated target: Indicates the accession number for an miRNA within the Sanger miRBase database.
def-source: NCI

Axiom
annotated source: miRBase_ID
annotated property: has exact synonym
annotated target: miRBase_ID
term-group: PT
term-source: NCI

Neoplastic_Status
type: AnnotationProperty
definition: The morphologic, clinical, and genetic profile of a neoplastic growth that defines it as non-cancerous, cancerous, or of uncertain cancerous potential.
code: P363
Semantic_Type: Conceptual Entity
Display_Name: Neoplastic Status
Preferred_Name: Neoplastic_Status
Contributing_Source: FDA
has exact synonym: Neoplastic_Status
range: NCIT Neoplastic Status-enum

Axiom
annotated source: Neoplastic_Status
annotated property: definition
annotated target: The morphologic, clinical, and genetic profile of a neoplastic growth that defines it as non-cancerous, cancerous, or of uncertain cancerous potential.
def-source: NCI

Axiom
annotated source: Neoplastic_Status
annotated property: has exact synonym
annotated target: Neoplastic_Status
term-group: PT
term-source: NCI

OLD_ASSOCIATION
type: AnnotationProperty
definition: Used to store the name and value of associations present at the time a concept was retired.
code: P364
Semantic_Type: Conceptual Entity
Preferred_Name: OLD_ASSOCIATION
has exact synonym: OLD_ASSOCIATION
range: string

Axiom
annotated source: OLD_ASSOCIATION
annotated property: definition
annotated target: Used to store the name and value of associations present at the time a concept was retired.
def-source: NCI

Axiom
annotated source: OLD_ASSOCIATION
annotated property: has exact synonym
annotated target: OLD_ASSOCIATION
term-group: PT
term-source: NCI

OLD_SOURCE_ASSOCIATION
type: AnnotationProperty
definition: A property used to temporarily store the name and value of associations present at the time a concept is premerged or preretired, where the target of the association is the concept being retired. Values stored in this property are restored as associations on the source concept if the merge or retire is rejected.
code: P365
Preferred_Name: OLD_SOURCE_ASSOCIATION
has exact synonym: OLD_SOURCE_ASSOCIATION
range: string

Axiom
annotated source: OLD_SOURCE_ASSOCIATION
annotated property: definition
annotated target: A property used to temporarily store the name and value of associations present at the time a concept is premerged or preretired, where the target of the association is the concept being retired. Values stored in this property are restored as associations on the source concept if the merge or retire is rejected.
def-source: NCI

Axiom
annotated source: OLD_SOURCE_ASSOCIATION
annotated property: has exact synonym
annotated target: OLD_SOURCE_ASSOCIATION
term-group: PT
term-source: NCI

Legacy_Concept_Name
type: AnnotationProperty
read only: true
definition: A retired unique concept identifier created and stored as Concept Name by legacy EVS software. Use of these values was long discouraged, but continued as late as 2009 when creation of new values ceased and Concept Name was retired. Legacy values are intended solely to help resolve and update earlier coding.
code: P366
Semantic_Type: Conceptual Entity
Preferred_Name: Legacy Concept Name
has exact synonym: Legacy Concept Name
range: string

Axiom
annotated source: Legacy_Concept_Name
annotated property: definition
annotated target: A retired unique concept identifier created and stored as Concept Name by legacy EVS software. Use of these values was long discouraged, but continued as late as 2009 when creation of new values ceased and Concept Name was retired. Legacy values are intended solely to help resolve and update earlier coding.
def-source: NCI

Axiom
annotated source: Legacy_Concept_Name
annotated property: has exact synonym
annotated target: Legacy Concept Name
term-group: PT
term-source: NCI

PID_ID
type: AnnotationProperty
definition: Indicates the NCI/Nature Pathway Interaction Database ID code for a pathway. It can be used by the NCIt Browser to link a pathway concept to the source pathway information.
code: P367
Semantic_Type: Conceptual Entity
Preferred_Name: PID_ID
has exact synonym: PID_ID
range: string

Axiom
annotated source: PID_ID
annotated property: definition
annotated target: Indicates the NCI/Nature Pathway Interaction Database ID code for a pathway. It can be used by the NCIt Browser to link a pathway concept to the source pathway information.
def-source: NCI

Axiom
annotated source: PID_ID
annotated property: has exact synonym
annotated target: PID_ID
term-group: PT
term-source: NCI

CHEBI_ID
type: AnnotationProperty
definition: Indicates that a concept in the 'Drug, Food, Chemical or Biomedical Material' branch of the NCI thesaurus maps to a specific concept in the EBI Chemical Entities of Biological Interest database.
code: P368
Semantic_Type: Conceptual Entity
Preferred_Name: CHEBI_ID
has exact synonym: CHEBI_ID
range: string

Axiom
annotated source: CHEBI_ID
annotated property: definition
annotated target: Indicates that a concept in the 'Drug, Food, Chemical or Biomedical Material' branch of the NCI thesaurus maps to a specific concept in the EBI Chemical Entities of Biological Interest database.
def-source: NCI

Axiom
annotated source: CHEBI_ID
annotated property: has exact synonym
annotated target: CHEBI_ID
term-group: PT
term-source: NCI

HGNC_ID
type: AnnotationProperty
definition: Indicates that a concept in the 'Gene' branch of the NCI thesaurus maps to a HUGO Gene Nomenclature Committee certified gene.
code: P369
Semantic_Type: Conceptual Entity
Preferred_Name: HGNC_ID
has exact synonym: HGNC_ID
has exact synonym: HUGO_ID
range: string

Axiom
annotated source: HGNC_ID
annotated property: definition
annotated target: Indicates that a concept in the 'Gene' branch of the NCI thesaurus maps to a HUGO Gene Nomenclature Committee certified gene.
def-source: NCI

Axiom
annotated source: HGNC_ID
annotated property: has exact synonym
annotated target: HGNC_ID
term-group: PT
term-source: NCI

Axiom
annotated source: HGNC_ID
annotated property: has exact synonym
annotated target: HUGO_ID
term-group: SY
term-source: NCI

NICHD_Hierarchy_Term
type: AnnotationProperty
code: P371
Semantic_Type: Conceptual Entity
Preferred_Name: NICHD_Hierarchy_Term
Contributing_Source: NICHD
has exact synonym: NICHD_Hierarchy_Term
range: string

Axiom
annotated source: NICHD_Hierarchy_Term
annotated property: has exact synonym
annotated target: NICHD_Hierarchy_Term
term-group: PT
term-source: NCI

def-definition
type: AnnotationProperty
code: P377
Preferred_Name: def-definition

def-source
type: AnnotationProperty
code: P378
Preferred_Name: def-source
NCIT required: true
range: NCIT def-source-enum

attr
type: AnnotationProperty
code: P381
Preferred_Name: attr
range: string

term-name
type: AnnotationProperty
code: P382
Preferred_Name: term-name

term-group
type: AnnotationProperty
code: P383
Preferred_Name: term-group
NCIT required: true
range: NCIT term-group-enum

term-source
type: AnnotationProperty
code: P384
Preferred_Name: term-source
NCIT required: true
range: NCIT term-source-enum

source-code
type: AnnotationProperty
code: P385
Preferred_Name: source-code
range: string

subsource-name
type: AnnotationProperty
code: P386
Preferred_Name: subsource-name
range: string

go-id
type: AnnotationProperty
code: P387
Preferred_Name: go-id
NCIT required: true
range: string

go-term
type: AnnotationProperty
code: P388
Preferred_Name: go-term

go-evi
type: AnnotationProperty
code: P389
Preferred_Name: go-evi
NCIT required: true
range: string

go-source
type: AnnotationProperty
code: P390
Preferred_Name: go-source
NCIT required: true
range: NCIT go-source-enum

source-date
type: AnnotationProperty
code: P391
Preferred_Name: source-date
NCIT required: true
range: string

Target_Term
type: AnnotationProperty
code: P392
Preferred_Name: Target_Term
range: string

Relationship_to_Target
type: AnnotationProperty
code: P393
Preferred_Name: Relationship_to_Target
NCIT required: true
range: NCIT Relationshipt to Target-enum

Target_Term_Type
type: AnnotationProperty
code: P394
Preferred_Name: Target_Term_Type
NCIT required: true
range: NCIT Target Term Type-enum

Target_Code
type: AnnotationProperty
code: P395
Preferred_Name: Target_Code
NCIT required: true
range: string

Target_Terminology
type: AnnotationProperty
code: P396
Preferred_Name: Target_Terminology
NCIT required: true
range: NCIT Target Terminology-enum

FULL_SYN
type: AnnotationProperty
definition: Fully qualified synonym, contains the string, term type, source, and an optional source code if appropriate. Each subfield is deliniated to facilitate interpretation by software.
code: P90
Semantic_Type: Conceptual Entity
Display_Name: Term & Source Data
Preferred_Name: FULL_SYN
has exact synonym: FULL_SYN
has exact synonym: Synonym with Source Data
range: NCIT textArea

Subsource
type: AnnotationProperty
definition: Currently used by MMHCC to identify the source of various mouse disease concepts.
code: P92
Semantic_Type: Conceptual Entity
Display_Name: Subsource
Preferred_Name: Subsource
has exact synonym: Subsource
range: string

Axiom
annotated source: Subsource
annotated property: definition
annotated target: Currently used by MMHCC to identify the source of various mouse disease concepts.
def-source: NCI

Axiom
annotated source: Subsource
annotated property: has exact synonym
annotated target: Subsource
term-group: PT
term-source: NCI

Swiss_Prot
type: AnnotationProperty
definition: Indicates the accession number for a Protein within the Swiss-Prot database.
code: P93
Semantic_Type: Conceptual Entity
Display_Name: Swiss Prot
Preferred_Name: Swiss_Prot
has exact synonym: Swiss_Prot
range: string

Axiom
annotated source: Swiss_Prot
annotated property: definition
annotated target: Indicates the accession number for a Protein within the Swiss-Prot database.
def-source: NCI

Axiom
annotated source: Swiss_Prot
annotated property: has exact synonym
annotated target: Swiss_Prot
term-group: PT
term-source: NCI

Gene_Encodes_Product
type: AnnotationProperty
definition: Indicates the protein or RNA product expressed by a gene.
code: P96
Semantic_Type: Conceptual Entity
Display_Name: Gene Encodes Product
Preferred_Name: Gene_Encodes_Product
DesignNote: This represents the reciprocal relationship of the role Gene_Product_Encoded_by_Gene
has exact synonym: Gene_Encodes_Product
range: string

Axiom
annotated source: Gene_Encodes_Product
annotated property: definition
annotated target: Indicates the protein or RNA product expressed by a gene.
def-source: NCI

Axiom
annotated source: Gene_Encodes_Product
annotated property: has exact synonym
annotated target: Gene_Encodes_Product
term-group: PT
term-source: NCI

DEFINITION
type: AnnotationProperty
definition: English language definitions of what NCI means by the concept. These are limited to 1024 characters. They may also include information about the definition's source and attribution in a form that can easily be interpreted by software.
code: P97
Semantic_Type: Conceptual Entity
Display_Name: Definition
Preferred_Name: DEFINITION
has exact synonym: DEFINITION
range: NCIT textArea

DesignNote
type: AnnotationProperty
definition: Design notes are notations made by NCI vocabulary curators. They are intended to provide supplemental, unstructured information to the user or additional insight about the concept.
code: P98
Semantic_Type: Conceptual Entity
Display_Name: DesignNote
Preferred_Name: DesignNote
has exact synonym: DesignNote
range: string

Axiom
annotated source: DesignNote
annotated property: definition
annotated target: Design notes are notations made by NCI vocabulary curators. They are intended to provide supplemental, unstructured information to the user or additional insight about the concept.
def-source: NCI

Axiom
annotated source: DesignNote
annotated property: has exact synonym
annotated target: DesignNote
term-group: PT
term-source: NCI

subset property
type: AnnotationProperty

has exact synonym
type: AnnotationProperty
definition: Fully qualified synonym, contains the string, term type, source, and an optional source code if appropriate. Each subfield is deliniated to facilitate interpretation by software.
has exact synonym: FULL_SYN
has exact synonym: Synonym with Source Data

Axiom
annotated source: has exact synonym
annotated property: definition
annotated target: Fully qualified synonym, contains the string, term type, source, and an optional source code if appropriate. Each subfield is deliniated to facilitate interpretation by software.
def-source: NCI

Axiom
annotated source: has exact synonym
annotated property: has exact synonym
annotated target: FULL_SYN
term-group: PT
term-source: NCI

Axiom
annotated source: has exact synonym
annotated property: has exact synonym
annotated target: Synonym with Source Data
term-group: SY
term-source: NCI

in subset
type: AnnotationProperty

comment
range: NCIT textArea

label

NCIT Concept Status-enum
type: Datatype
equivalent class: Datatype
  one of: Concept_Pending_Approval
  one of: Deprecated_Concept
  one of: Header_Concept
  one of: Obsolete_Concept
  one of: Provisional_Concept
  one of: Retired_Concept

NCIT Contributing Source-enum
type: Datatype
equivalent class: Datatype
  one of: ACC
  one of: BRIDG
  one of: CDISC
  one of: COH
  one of: CRCH
  one of: CTCAE
  one of: CTEP
  one of: CTRP
  one of: CareLex
  one of: FDA
  one of: GAIA
  one of: HL7
  one of: ICH
  one of: MedDRA
  one of: NCCN
  one of: NCPDP
  one of: NICHD
  one of: PI-RADS
  one of: UCUM

NCIT Def Curator-enum
type: Datatype
equivalent class: Datatype
  one of: NCI Drug Dictionary

NCIT Extensible List-enum
type: Datatype
equivalent class: Datatype
  one of: NA
  one of: No
  one of: Yes

NCIT FDA Table-enum
type: Datatype
equivalent class: Datatype
  one of: Device Problem Code (Appendix B)
  one of: Dosage Form (C-DRG-00201)
  one of: Marketing Category (C-DRG-0935)
  one of: Package Type (C-DRG-00907)
  one of: Patient Code (Appendix B)
  one of: Plant Part (C-DRG-00924)
  one of: Potency (C-DRG-00501)
  one of: Route of Administration (C-DRG-00301)
  one of: SPL Color (C-DRG-00927)
  one of: SPL DEA Schedule (C-DRG-0933)
  one of: SPL Flavor (C-DRG-0934)
  one of: SPL Shape (C-DRG-00929)

NCIT Neoplastic Status-enum
type: Datatype
equivalent class: Datatype
  one of: Benign
  one of: Malignant
  one of: Precancerous
  one of: Uncertain Malignant Potential
  one of: Undetermined

NCIT Project Name-enum
type: Datatype
equivalent class: Datatype
  one of: Alliance
  one of: COG
  one of: CTRP Biomarker Abstraction
  one of: DCP
  one of: Duke Sarcoma Project
  one of: NCCN
  one of: NCI CCR
  one of: PopSci SIG
  one of: Rave
  one of: TCGA
  one of: caDSR General

NCIT Publish Value Set-enum
type: Datatype
equivalent class: Datatype
  one of: No
  one of: Yes

NCIT Relationshipt to Target-enum
type: Datatype
equivalent class: Datatype
  one of: Broader Than
  one of: Has Synonym
  one of: Narrower Than
  one of: Related To

NCIT Semantic Type-enum
type: Datatype
equivalent class: Datatype
  one of: Acquired Abnormality
  one of: Activity
  one of: Age Group
  one of: Amino Acid Sequence
  one of: Amino Acid, Peptide, or Protein
  one of: Amphibian
  one of: Anatomical Abnormality
  one of: Anatomical Structure
  one of: Animal
  one of: Antibiotic
  one of: Archaeon
  one of: Bacterium
  one of: Behavior
  one of: Biologic Function
  one of: Biologically Active Substance
  one of: Biomedical Occupation or Discipline
  one of: Biomedical or Dental Material
  one of: Bird
  one of: Body Location or Region
  one of: Body Part, Organ, or Organ Component
  one of: Body Space or Junction
  one of: Body Substance
  one of: Body System
  one of: Carbohydrate Sequence
  one of: Cell
  one of: Cell Component
  one of: Cell Function
  one of: Cell or Molecular Dysfunction
  one of: Chemical
  one of: Chemical Viewed Functionally
  one of: Chemical Viewed Structurally
  one of: Classification
  one of: Clinical Attribute
  one of: Clinical Drug
  one of: Conceptual Entity
  one of: Congenital Abnormality
  one of: Daily or Recreational Activity
  one of: Diagnostic Procedure
  one of: Disease or Syndrome
  one of: Drug Delivery Device
  one of: Educational Activity
  one of: Element, Ion, or Isotope
  one of: Embryonic Structure
  one of: Entity
  one of: Environmental Effect of Humans
  one of: Enzyme
  one of: Eukaryote
  one of: Event
  one of: Experimental Model of Disease
  one of: Family Group
  one of: Finding
  one of: Fish
  one of: Food
  one of: Fully Formed Anatomical Structure
  one of: Functional Concept
  one of: Fungus
  one of: Gene or Genome
  one of: Genetic Function
  one of: Geographic Area
  one of: Governmental or Regulatory Activity
  one of: Group
  one of: Group Attribute
  one of: Hazardous or Poisonous Substance
  one of: Health Care Activity
  one of: Health Care Related Organization
  one of: Hormone
  one of: Human
  one of: Human-caused Phenomenon or Process
  one of: Idea or Concept
  one of: Immunologic Factor
  one of: Indicator, Reagent, or Diagnostic Aid
  one of: Individual Behavior
  one of: Injury or Poisoning
  one of: Inorganic Chemical
  one of: Intellectual Product
  one of: Laboratory Procedure
  one of: Laboratory or Test Result
  one of: Language
  one of: Machine Activity

NCIT TVS Location-enum
type: Datatype
equivalent class: Datatype
  one of: TVS_ADaM_Component
  one of: TVS_CDASH_Component
  one of: TVS_CDISC_ADaM
  one of: TVS_CDISC_CDASH
  one of: TVS_CDISC_Clinical_Classification
  one of: TVS_CDISC_Component
  one of: TVS_CDISC_Functional_Test
  one of: TVS_CDISC_Protocol
  one of: TVS_CDISC_Questionnaire
  one of: TVS_CDISC_SDTM
  one of: TVS_CDISC_SEND
  one of: TVS_CDRH_GUID_Component
  one of: TVS_CareLex
  one of: TVS_Clinical_Classification_Component
  one of: TVS_DICOM_Component
  one of: TVS_FDA_Device
  one of: TVS_FDA_Device_Component
  one of: TVS_FDA_QM
  one of: TVS_FDA_QM_Component
  one of: TVS_FDA_SPL
  one of: TVS_FDA_SPL_Biz_Ops
  one of: TVS_FDA_SPL_Biz_Ops_Component
  one of: TVS_FDA_SPL_Blood
  one of: TVS_FDA_SPL_Blood_Component
  one of: TVS_FDA_SPL_Blood_Tissue
  one of: TVS_FDA_SPL_Blood_Tissue_Component
  one of: TVS_FDA_SPL_Component
  one of: TVS_FDA_SPL_REMS
  one of: TVS_FDA_SPL_REMS_Component
  one of: TVS_FDA_SPL_Tissue
  one of: TVS_FDA_SPL_Tissue_Component
  one of: TVS_FDA_UNII
  one of: TVS_FDA_eManufacturing_Component
  one of: TVS_Functional_Test_Component
  one of: TVS_GAIA
  one of: TVS_GAIA_Component
  one of: TVS_ICSR
  one of: TVS_ICSR_Component
  one of: TVS_IDMP_Component
  one of: TVS_NCI_Component
  one of: TVS_NCI_Drug_Component
  one of: TVS_NCI_Neoplasm_Component
  one of: TVS_NCPDP
  one of: TVS_NCPDP_Component
  one of: TVS_NICHD
  one of: TVS_NICHD_Component
  one of: TVS_PIRADS_Component
  one of: TVS_Protocol_Component
  one of: TVS_Questionnaire_Component
  one of: TVS_SDTM_Component
  one of: TVS_SEND_Component
  one of: TVS_SPL_PQCMC
  one of: TVS_SPL_PQCMC_Component
  one of: TVS_SPL_PQCMC_Test_Category
  one of: TVS_SPL_PQCMC_Test_Category_Component
  one of: TVS_UCUM_Component
  one of: TVS_eCTD_Component

NCIT Target Term Type-enum
type: Datatype
equivalent class: Datatype
  one of: LLT
  one of: PT
  one of: SY

NCIT Target Terminology-enum
type: Datatype
equivalent class: Datatype
  one of: GAIA
  one of: MedDRA

NCIT def-source-enum
type: Datatype
NCIT default: NCI
equivalent class: Datatype
  one of: ACC
  one of: BIOCARTA
  one of: BRIDG
  one of: CADSR
  one of: CDISC
  one of: CRCH
  one of: CSP2000
  one of: CSP2003
  one of: CTCAE
  one of: CTEP
  one of: CareLex
  one of: DICOM
  one of: FDA
  one of: GAIA
  one of: ICD03
  one of: KEGG
  one of: MMHCC
  one of: MSH2001
  one of: MSH2002_06_01
  one of: MSH2003_2003_05_12
  one of: NCI
  one of: NCI-DEFCURATOR
  one of: NCI-GLOSS
  one of: NICHD
  one of: SPL

NCIT go-source-enum
type: Datatype
equivalent class: Datatype
  one of: CGAP
  one of: NCBI
  one of: NCI

NCIT term-group-enum
type: Datatype
NCIT default: PT
equivalent class: Datatype
  one of: AB
  one of: AD
  one of: AQ
  one of: AQS
  one of: BR
  one of: CA2
  one of: CA3
  one of: CN
  one of: CNU
  one of: CS
  one of: DN
  one of: FB
  one of: HD
  one of: LLT
  one of: PT
  one of: SN
  one of: SY

NCIT term-source-enum
type: Datatype
NCIT default: NCI
equivalent class: Datatype
  one of: ACC
  one of: ANSI
  one of: BIOCARTA
  one of: BRIDG
  one of: CADSR
  one of: CDC
  one of: CDISC
  one of: CRCH
  one of: CTCAE
  one of: CTEP
  one of: CTRM
  one of: CTRP
  one of: CareLex
  one of: DCP
  one of: DICOM
  one of: DTP
  one of: FDA
  one of: GAIA
  one of: GENC
  one of: HGNC
  one of: HL7
  one of: ICH
  one of: JAX
  one of: KEGG
  one of: MTH
  one of: MedDRA
  one of: NCI
  one of: NCI-GLOSS
  one of: NCPDP
  one of: NICHD
  one of: PI-RADS
  one of: PID
  one of: SEER
  one of: UCUM

Disease_Has_Associated_Anatomic_Site
type: ObjectProperty
definition: A role used to relate a disease to the general site, structure or system where the specific pathological process is located. The domain and the range for this role are 'Disease, Disorder or Finding' and 'Anatomic Structure, System, or Substance', respectively.
code: R100
Semantic_Type: Conceptual Entity
Display_Name: Has Associated Anatomic Site
Preferred_Name: Disease_Has_Associated_Anatomic_Site
DesignNote: The role, Disease_Has_Associated_Anatomic_Site, is more general than the role, Disease_Has_Primary_Anatomic_Site. Furthermore, when viewed with the role, Disease_Has_Metastatic_Anatomic_Site, there emerges a role hierarchy, where one role specializes the meaning of another, more general role. Roles relating disease to anatomy start with a general assertion of association, often at very high level (e.g. Skin Disorder and Skin), and then add more specific primary/metastatic associations where appropriate for more specific concepts.
has exact synonym: Disease_Has_Associated_Anatomic_Site

Axiom
annotated source: Disease_Has_Associated_Anatomic_Site
annotated property: definition
annotated target: A role used to relate a disease to the general site, structure or system where the specific pathological process is located. The domain and the range for this role are 'Disease, Disorder or Finding' and 'Anatomic Structure, System, or Substance', respectively.
def-source: NCI

Axiom
annotated source: Disease_Has_Associated_Anatomic_Site
annotated property: has exact synonym
annotated target: Disease_Has_Associated_Anatomic_Site
term-group: PT
term-source: NCI

Disease_Has_Primary_Anatomic_Site
type: ObjectProperty
definition: A role used to relate a disease to the anatomical site where the originating pathological process is located. The domain and the range for this role are 'Disease, Disorder or Finding' and 'Anatomic Structure, System, or Substance', respectively.
code: R101
Semantic_Type: Conceptual Entity
Display_Name: Has Primary Anatomic Site
Preferred_Name: Disease_Has_Primary_Anatomic_Site
DesignNote: This role can be viewed as a specialization of Disease_Has_Associated_Anatomic_Site.
has exact synonym: Disease_Has_Primary_Anatomic_Site

Axiom
annotated source: Disease_Has_Primary_Anatomic_Site
annotated property: definition
annotated target: A role used to relate a disease to the anatomical site where the originating pathological process is located. The domain and the range for this role are 'Disease, Disorder or Finding' and 'Anatomic Structure, System, or Substance', respectively.
def-source: NCI

Axiom
annotated source: Disease_Has_Primary_Anatomic_Site
annotated property: has exact synonym
annotated target: Disease_Has_Primary_Anatomic_Site
term-group: PT
term-source: NCI

Disease_Has_Metastatic_Anatomic_Site
type: ObjectProperty
definition: A role used to relate a disease to the site of a metastatic lesion associated with the disease. The domain and the range for this role are 'Disease, Disorder or Finding' and 'Anatomic Structure, System, or Substance', respectively.
code: R102
Semantic_Type: Conceptual Entity
Display_Name: Has Metastatic Anatomic Site
Preferred_Name: Disease_Has_Metastatic_Anatomic_Site
DesignNote: The role can be viewed as a specialization of Disease_Has_Associated_Anatomic_Site.
has exact synonym: Disease_Has_Metastatic_Anatomic_Site

Axiom
annotated source: Disease_Has_Metastatic_Anatomic_Site
annotated property: definition
annotated target: A role used to relate a disease to the site of a metastatic lesion associated with the disease. The domain and the range for this role are 'Disease, Disorder or Finding' and 'Anatomic Structure, System, or Substance', respectively.
def-source: NCI

Axiom
annotated source: Disease_Has_Metastatic_Anatomic_Site
annotated property: has exact synonym
annotated target: Disease_Has_Metastatic_Anatomic_Site
term-group: PT
term-source: NCI

Disease_Has_Normal_Tissue_Origin
type: ObjectProperty
definition: A role used to relate a disease to the type of normal tissue in which the disease process began. The domain and the range for this role are 'Disease, Disorder or Finding' and 'Anatomic Structure, System, or Substance', respectively.
code: R103
Semantic_Type: Conceptual Entity
Display_Name: Has Normal Tissue Origin
Preferred_Name: Disease_Has_Normal_Tissue_Origin
DesignNote: This non-defining role represents non-essential characteristics which are true in some, but not all, cases, yet have an association frequent enough to be of interest.
has exact synonym: Disease_Has_Normal_Tissue_Origin

Axiom
annotated source: Disease_Has_Normal_Tissue_Origin
annotated property: definition
annotated target: A role used to relate a disease to the type of normal tissue in which the disease process began. The domain and the range for this role are 'Disease, Disorder or Finding' and 'Anatomic Structure, System, or Substance', respectively.
def-source: NCI

Axiom
annotated source: Disease_Has_Normal_Tissue_Origin
annotated property: has exact synonym
annotated target: Disease_Has_Normal_Tissue_Origin
term-group: PT
term-source: NCI

Disease_Has_Normal_Cell_Origin
type: ObjectProperty
definition: A role used to relate a disease to the type of normal cell in which the disease process begins. The domain and the range for this role are 'Disease, Disorder or Finding' and 'Anatomic Structure, System, or Substance', respectively.
code: R104
Semantic_Type: Conceptual Entity
Display_Name: Has Normal Cell Origin
Preferred_Name: Disease_Has_Normal_Cell_Origin
has exact synonym: Disease_Has_Normal_Cell_Origin

Axiom
annotated source: Disease_Has_Normal_Cell_Origin
annotated property: definition
annotated target: A role used to relate a disease to the type of normal cell in which the disease process begins. The domain and the range for this role are 'Disease, Disorder or Finding' and 'Anatomic Structure, System, or Substance', respectively.
def-source: NCI

Axiom
annotated source: Disease_Has_Normal_Cell_Origin
annotated property: has exact synonym
annotated target: Disease_Has_Normal_Cell_Origin
term-group: PT
term-source: NCI

Disease_Has_Abnormal_Cell
type: ObjectProperty
definition: A role used to relate a disease to the type of neoplastic cell present in and characteristic of the disease. The domain and the range for this role are 'Disease, Disorder or Finding' and 'Abnormal Cell', respectively.
code: R105
Semantic_Type: Conceptual Entity
Display_Name: Has Abnormal Cell
Preferred_Name: Disease_Has_Abnormal_Cell
has exact synonym: Disease_Has_Abnormal_Cell

Axiom
annotated source: Disease_Has_Abnormal_Cell
annotated property: definition
annotated target: A role used to relate a disease to the type of neoplastic cell present in and characteristic of the disease. The domain and the range for this role are 'Disease, Disorder or Finding' and 'Abnormal Cell', respectively.
def-source: NCI

Axiom
annotated source: Disease_Has_Abnormal_Cell
annotated property: has exact synonym
annotated target: Disease_Has_Abnormal_Cell
term-group: PT
term-source: NCI

Disease_Has_Molecular_Abnormality
type: ObjectProperty
definition: A role used to relate a disease to a molecular abnormality that is present in the specified disease state. The domain and the range for this role are 'Disease, Disorder or Finding' and 'Molecular Abnormality', respectively.
code: R106
Semantic_Type: Conceptual Entity
Display_Name: Has Molecular Abnormality
Preferred_Name: Disease_Has_Molecular_Abnormality
has exact synonym: Disease_Has_Molecular_Abnormality

Axiom
annotated source: Disease_Has_Molecular_Abnormality
annotated property: definition
annotated target: A role used to relate a disease to a molecular abnormality that is present in the specified disease state. The domain and the range for this role are 'Disease, Disorder or Finding' and 'Molecular Abnormality', respectively.
def-source: NCI

Axiom
annotated source: Disease_Has_Molecular_Abnormality
annotated property: has exact synonym
annotated target: Disease_Has_Molecular_Abnormality
term-group: PT
term-source: NCI

Disease_Has_Cytogenetic_Abnormality
type: ObjectProperty
definition: A role used to relate a disease to the type of chromosomal abnormality present in the specified disease state. The domain and the range for this role are 'Disease, Disorder or Finding' and 'Molecular Abnormality', respectively.
code: R107
Semantic_Type: Conceptual Entity
Display_Name: Has Cytogenetic Abnormality
Preferred_Name: Disease_Has_Cytogenetic_Abnormality
has exact synonym: Disease_Has_Cytogenetic_Abnormality

Axiom
annotated source: Disease_Has_Cytogenetic_Abnormality
annotated property: definition
annotated target: A role used to relate a disease to the type of chromosomal abnormality present in the specified disease state. The domain and the range for this role are 'Disease, Disorder or Finding' and 'Molecular Abnormality', respectively.
def-source: NCI

Axiom
annotated source: Disease_Has_Cytogenetic_Abnormality
annotated property: has exact synonym
annotated target: Disease_Has_Cytogenetic_Abnormality
term-group: PT
term-source: NCI

Disease_Has_Finding
type: ObjectProperty
definition: A role used to relate a disease to a clinical observation, sign or symptom present in and characteristic of the disease. Both the domain and range for this role are 'Disease, Disorder or Finding'.
code: R108
Semantic_Type: Conceptual Entity
Display_Name: Has Finding
Preferred_Name: Disease_Has_Finding
has exact synonym: Disease_Has_Finding

Axiom
annotated source: Disease_Has_Finding
annotated property: definition
annotated target: A role used to relate a disease to a clinical observation, sign or symptom present in and characteristic of the disease. Both the domain and range for this role are 'Disease, Disorder or Finding'.
def-source: NCI

Axiom
annotated source: Disease_Has_Finding
annotated property: has exact synonym
annotated target: Disease_Has_Finding
term-group: PT
term-source: NCI

Disease_Is_Grade
type: ObjectProperty
definition: A role used to relate a disease to a grading system which classifies the cancer cells in terms of how abnormal they appear when examined under a microscope. The domain and the range for this role are 'Disease, Disorder or Finding' and 'Property or_Attribute', respectively.
code: R110
Semantic_Type: Conceptual Entity
Display_Name: Is Grade
Preferred_Name: Disease_Is_Grade
has exact synonym: Disease_Is_Grade

Axiom
annotated source: Disease_Is_Grade
annotated property: definition
annotated target: A role used to relate a disease to a grading system which classifies the cancer cells in terms of how abnormal they appear when examined under a microscope. The domain and the range for this role are 'Disease, Disorder or Finding' and 'Property or_Attribute', respectively.
def-source: NCI

Axiom
annotated source: Disease_Is_Grade
annotated property: has exact synonym
annotated target: Disease_Is_Grade
term-group: PT
term-source: NCI

Disease_May_Have_Normal_Tissue_Origin
type: ObjectProperty
definition: A role used to represent that a normal tissue type will only be the type of origin in some cases of the disease. The domain and the range for this role are 'Disease, Disorder or Finding' and 'Anatomic Structure, System, or Substance', respectively.
code: R111
Semantic_Type: Conceptual Entity
Display_Name: May Have Normal Tissue Origin
Preferred_Name: Disease_May_Have_Normal_Tissue_Origin
has exact synonym: Disease_May_Have_Normal_Tissue_Origin

Axiom
annotated source: Disease_May_Have_Normal_Tissue_Origin
annotated property: definition
annotated target: A role used to represent that a normal tissue type will only be the type of origin in some cases of the disease. The domain and the range for this role are 'Disease, Disorder or Finding' and 'Anatomic Structure, System, or Substance', respectively.
def-source: NCI

Axiom
annotated source: Disease_May_Have_Normal_Tissue_Origin
annotated property: has exact synonym
annotated target: Disease_May_Have_Normal_Tissue_Origin
term-group: PT
term-source: NCI

Disease_May_Have_Normal_Cell_Origin
type: ObjectProperty
definition: A role used to represent that a normal cell type will only be the type of origin in some cases of the disease. The domain and the range for this role are 'Disease, Disorder or Finding' and 'Anatomic Structure, System, or Substance', respectively.
code: R112
Semantic_Type: Conceptual Entity
Display_Name: May Have Normal Cell Origin
Preferred_Name: Disease_May_Have_Normal_Cell_Origin
has exact synonym: Disease_May_Have_Normal_Cell_Origin

Axiom
annotated source: Disease_May_Have_Normal_Cell_Origin
annotated property: definition
annotated target: A role used to represent that a normal cell type will only be the type of origin in some cases of the disease. The domain and the range for this role are 'Disease, Disorder or Finding' and 'Anatomic Structure, System, or Substance', respectively.
def-source: NCI

Axiom
annotated source: Disease_May_Have_Normal_Cell_Origin
annotated property: has exact synonym
annotated target: Disease_May_Have_Normal_Cell_Origin
term-group: PT
term-source: NCI

Disease_May_Have_Abnormal_Cell
type: ObjectProperty
definition: A role used to represent that particular neoplastic cell types will only be present in some cases of the disease. The domain and the range for this role are 'Disease, Disorder or Finding' and 'Abnormal Cell', respectively.
code: R113
Semantic_Type: Conceptual Entity
Display_Name: May Have Abnormal Cell
Preferred_Name: Disease_May_Have_Abnormal_Cell
has exact synonym: Disease_May_Have_Abnormal_Cell

Axiom
annotated source: Disease_May_Have_Abnormal_Cell
annotated property: definition
annotated target: A role used to represent that particular neoplastic cell types will only be present in some cases of the disease. The domain and the range for this role are 'Disease, Disorder or Finding' and 'Abnormal Cell', respectively.
def-source: NCI

Axiom
annotated source: Disease_May_Have_Abnormal_Cell
annotated property: has exact synonym
annotated target: Disease_May_Have_Abnormal_Cell
term-group: PT
term-source: NCI

Disease_May_Have_Cytogenetic_Abnormality
type: ObjectProperty
definition: A role used to represent that a particular cytogenetic abnormality will only be present in some cases of the disease. The domain and the range for this role are 'Disease, Disorder or Finding' and 'Molecular Abnormality', respectively.
code: R114
Semantic_Type: Conceptual Entity
Display_Name: May Have Cytogenetic Abnormality
Preferred_Name: Disease_May_Have_Cytogenetic_Abnormality
has exact synonym: Disease_May_Have_Cytogenetic_Abnormality

Axiom
annotated source: Disease_May_Have_Cytogenetic_Abnormality
annotated property: definition
annotated target: A role used to represent that a particular cytogenetic abnormality will only be present in some cases of the disease. The domain and the range for this role are 'Disease, Disorder or Finding' and 'Molecular Abnormality', respectively.
def-source: NCI

Axiom
annotated source: Disease_May_Have_Cytogenetic_Abnormality
annotated property: has exact synonym
annotated target: Disease_May_Have_Cytogenetic_Abnormality
term-group: PT
term-source: NCI

Disease_May_Have_Finding
type: ObjectProperty
definition: A role used to represent that a clinical observation, sign or symptom will only be observed in some cases of the disease. Both the domain and range for this role are 'Disease, Disorder or Finding'.
code: R115
Semantic_Type: Conceptual Entity
Display_Name: May Have Finding
Preferred_Name: Disease_May_Have_Finding
has exact synonym: Disease_May_Have_Finding

Axiom
annotated source: Disease_May_Have_Finding
annotated property: definition
annotated target: A role used to represent that a clinical observation, sign or symptom will only be observed in some cases of the disease. Both the domain and range for this role are 'Disease, Disorder or Finding'.
def-source: NCI

Axiom
annotated source: Disease_May_Have_Finding
annotated property: has exact synonym
annotated target: Disease_May_Have_Finding
term-group: PT
term-source: NCI

Disease_May_Have_Associated_Disease
type: ObjectProperty
definition: A role used to represent that another disease or disorder will only be observed in some cases of the specified disease. Both the domain and the range for this role are 'Disease, Disorder or Finding'.
code: R116
Semantic_Type: Conceptual Entity
Display_Name: May Have Associated Disease
Preferred_Name: Disease_May_Have_Associated_Disease
has exact synonym: Disease_May_Have_Associated_Disease

Axiom
annotated source: Disease_May_Have_Associated_Disease
annotated property: definition
annotated target: A role used to represent that another disease or disorder will only be observed in some cases of the specified disease. Both the domain and the range for this role are 'Disease, Disorder or Finding'.
def-source: NCI

Axiom
annotated source: Disease_May_Have_Associated_Disease
annotated property: has exact synonym
annotated target: Disease_May_Have_Associated_Disease
term-group: PT
term-source: NCI

Chemical_Or_Drug_Is_Metabolized_By_Enzyme
type: ObjectProperty
definition: A role used to specify that an enzyme is directly responsible for metabolizing a chemical or drug into an active form, inactive form, or both. The domain and range for this role are 'Drug, Food, Chemical or Biomedical Material' and 'Gene Product', respectively.
code: R122
Semantic_Type: Conceptual Entity
Display_Name: Is Metabolized By Enzyme
Preferred_Name: Chemical_Or_Drug_Is_Metabolized_By_Enzyme
has exact synonym: Chemical_Or_Drug_Is_Metabolized_By_Enzyme

Axiom
annotated source: Chemical_Or_Drug_Is_Metabolized_By_Enzyme
annotated property: definition
annotated target: A role used to specify that an enzyme is directly responsible for metabolizing a chemical or drug into an active form, inactive form, or both. The domain and range for this role are 'Drug, Food, Chemical or Biomedical Material' and 'Gene Product', respectively.
def-source: NCI

Axiom
annotated source: Chemical_Or_Drug_Is_Metabolized_By_Enzyme
annotated property: has exact synonym
annotated target: Chemical_Or_Drug_Is_Metabolized_By_Enzyme
term-group: PT
term-source: NCI

Chemotherapy_Regimen_Has_Component
type: ObjectProperty
definition: A role used to specify the component agents which are used in a particular chemotherapy regimen or agent combination. The domain and the range for this role are 'Chemotherapy Regimen or Agent Combination' and 'Drug, Food, Chemical or Biomedical Material', respectively.
code: R123
Semantic_Type: Conceptual Entity
Display_Name: Has Component
Preferred_Name: Chemotherapy_Regimen_Has_Component
has exact synonym: Chemotherapy_Regimen_Has_Component

Axiom
annotated source: Chemotherapy_Regimen_Has_Component
annotated property: definition
annotated target: A role used to specify the component agents which are used in a particular chemotherapy regimen or agent combination. The domain and the range for this role are 'Chemotherapy Regimen or Agent Combination' and 'Drug, Food, Chemical or Biomedical Material', respectively.
def-source: NCI

Axiom
annotated source: Chemotherapy_Regimen_Has_Component
annotated property: has exact synonym
annotated target: Chemotherapy_Regimen_Has_Component
term-group: PT
term-source: NCI

Chemical_Or_Drug_Has_Mechanism_Of_Action
type: ObjectProperty
definition: A role used to imply the interaction or binding of an active ingredient of a drug/chemical agent at the molecular level with its target. When possible, the role value should reflect the direct alteration of function of a target molecule or complex. The domain and range for this role are 'Drug, Food, Chemical or Biomedical Material' and 'Biological Process', respectively.
code: R124
Semantic_Type: Conceptual Entity
Display_Name: Has Mechanism Of Action
Preferred_Name: Chemical_Or_Drug_Has_Mechanism_Of_Action
has exact synonym: Chemical_Or_Drug_Has_Mechanism_Of_Action

Axiom
annotated source: Chemical_Or_Drug_Has_Mechanism_Of_Action
annotated property: definition
annotated target: A role used to imply the interaction or binding of an active ingredient of a drug/chemical agent at the molecular level with its target. When possible, the role value should reflect the direct alteration of function of a target molecule or complex. The domain and range for this role are 'Drug, Food, Chemical or Biomedical Material' and 'Biological Process', respectively.
def-source: NCI

Axiom
annotated source: Chemical_Or_Drug_Has_Mechanism_Of_Action
annotated property: has exact synonym
annotated target: Chemical_Or_Drug_Has_Mechanism_Of_Action
term-group: PT
term-source: NCI

Chemical_Or_Drug_Has_Physiologic_Effect
type: ObjectProperty
definition: A role used to describe the primary detectable alterations of subcellular, cellular, tissue, or organ functions that directly result from alteration of function of a target biological molecule or complex caused by interaction of a therapeutic agent with a target molecule or complex. The domain and range for this role are 'Drug, Food, Chemical or Biomedical Material' and 'Biological Process', respectively.
code: R125
Semantic_Type: Conceptual Entity
Display_Name: Has Physiologic Effect
Preferred_Name: Chemical_Or_Drug_Has_Physiologic_Effect
has exact synonym: Chemical_Or_Drug_Has_Physiologic_Effect

Axiom
annotated source: Chemical_Or_Drug_Has_Physiologic_Effect
annotated property: definition
annotated target: A role used to describe the primary detectable alterations of subcellular, cellular, tissue, or organ functions that directly result from alteration of function of a target biological molecule or complex caused by interaction of a therapeutic agent with a target molecule or complex. The domain and range for this role are 'Drug, Food, Chemical or Biomedical Material' and 'Biological Process', respectively.
def-source: NCI

Axiom
annotated source: Chemical_Or_Drug_Has_Physiologic_Effect
annotated property: has exact synonym
annotated target: Chemical_Or_Drug_Has_Physiologic_Effect
term-group: PT
term-source: NCI

Disease_Has_Associated_Disease
type: ObjectProperty
definition: A role used to relate a disease to another disease or disorder, but without specification or limitation of the relationship (causality or timing for example). Both the domain and the range for this role are 'Disease, Disorder or Finding'.
code: R126
Semantic_Type: Conceptual Entity
Display_Name: Has Associated Disease
Preferred_Name: Disease_Has_Associated_Disease
has exact synonym: Disease_Has_Associated_Disease

Axiom
annotated source: Disease_Has_Associated_Disease
annotated property: definition
annotated target: A role used to relate a disease to another disease or disorder, but without specification or limitation of the relationship (causality or timing for example). Both the domain and the range for this role are 'Disease, Disorder or Finding'.
def-source: NCI

Axiom
annotated source: Disease_Has_Associated_Disease
annotated property: has exact synonym
annotated target: Disease_Has_Associated_Disease
term-group: PT
term-source: NCI

Gene_Is_Element_In_Pathway
type: ObjectProperty
definition: A role used to assert a relationship between a gene and a biochemical pathway in which its encoded gene product(s) participate. This relationship is used only when gene has been implicated in a pathway by the curated source (Biocarta, KEGG or PID). The domain and range for this role are 'Gene' and 'Biochemical Pathway', respectively.
code: R130
Semantic_Type: Conceptual Entity
Display_Name: Is Element In Pathway
Preferred_Name: Gene_Is_Element_In_Pathway
DesignNote: In NCI Thesaurus, pathways are derived from BioCarta and KEGG and are associated with genes and proteins that comprise these pathways.
has exact synonym: Gene_Is_Element_In_Pathway

Axiom
annotated source: Gene_Is_Element_In_Pathway
annotated property: definition
annotated target: A role used to assert a relationship between a gene and a biochemical pathway in which its encoded gene product(s) participate. This relationship is used only when gene has been implicated in a pathway by the curated source (Biocarta, KEGG or PID). The domain and range for this role are 'Gene' and 'Biochemical Pathway', respectively.
def-source: NCI

Axiom
annotated source: Gene_Is_Element_In_Pathway
annotated property: has exact synonym
annotated target: Gene_Is_Element_In_Pathway
term-group: PT
term-source: NCI

Gene_Product_Is_Element_In_Pathway
type: ObjectProperty
definition: A role used to assert a relationship between a gene product and a biochemical pathway in which it participates. This relationship is used only when a gene product has been implicated in a pathway by the curated source (Biocarta, KEGG or PID). The domain and range for this role are 'Gene Product' and 'Biochemical Pathway', respectively.
code: R131
Semantic_Type: Conceptual Entity
Display_Name: Is Element In Pathway
Preferred_Name: Gene_Product_Is_Element_In_Pathway
DesignNote: In NCI Thesaurus, pathways are derived from BioCarta and KEGG and are associated with genes and proteins that comprise these pathways.
has exact synonym: Gene_Product_Is_Element_In_Pathway

Axiom
annotated source: Gene_Product_Is_Element_In_Pathway
annotated property: definition
annotated target: A role used to assert a relationship between a gene product and a biochemical pathway in which it participates. This relationship is used only when a gene product has been implicated in a pathway by the curated source (Biocarta, KEGG or PID). The domain and range for this role are 'Gene Product' and 'Biochemical Pathway', respectively.
def-source: NCI

Axiom
annotated source: Gene_Product_Is_Element_In_Pathway
annotated property: has exact synonym
annotated target: Gene_Product_Is_Element_In_Pathway
term-group: PT
term-source: NCI

Gene_Has_Abnormality
type: ObjectProperty
definition: A role used to establish a link between a gene and the genetic or molecular abnormalities that have been observed in human cells and tissues associated with cancers (e.g., over- or under-expressed, amplified, translocated). The domain and range for this role are 'Gene' and 'Molecular Abnormality', respectively.
code: R132
Semantic_Type: Conceptual Entity
Display_Name: Has Abnormality
Preferred_Name: Gene_Has_Abnormality
has exact synonym: Gene_Has_Abnormality

Axiom
annotated source: Gene_Has_Abnormality
annotated property: definition
annotated target: A role used to establish a link between a gene and the genetic or molecular abnormalities that have been observed in human cells and tissues associated with cancers (e.g., over- or under-expressed, amplified, translocated). The domain and range for this role are 'Gene' and 'Molecular Abnormality', respectively.
def-source: NCI

Axiom
annotated source: Gene_Has_Abnormality
annotated property: has exact synonym
annotated target: Gene_Has_Abnormality
term-group: PT
term-source: NCI

Gene_Product_Has_Abnormality
type: ObjectProperty
definition: A role used to establish a link between a gene product and the molecular abnormalities that are observed in human cells and tissues in association with diseases such as cancers (e.g., over or under-expression of gene product). The domain and range for this role are 'Gene Product' and 'Molecular Abnormality', respectively.
code: R133
Semantic_Type: Conceptual Entity
Display_Name: Has Abnormality
Preferred_Name: Gene_Product_Has_Abnormality
has exact synonym: Gene_Product_Has_Abnormality

Axiom
annotated source: Gene_Product_Has_Abnormality
annotated property: definition
annotated target: A role used to establish a link between a gene product and the molecular abnormalities that are observed in human cells and tissues in association with diseases such as cancers (e.g., over or under-expression of gene product). The domain and range for this role are 'Gene Product' and 'Molecular Abnormality', respectively.
def-source: NCI

Axiom
annotated source: Gene_Product_Has_Abnormality
annotated property: has exact synonym
annotated target: Gene_Product_Has_Abnormality
term-group: PT
term-source: NCI

Disease_Excludes_Primary_Anatomic_Site
type: ObjectProperty
definition: A specializing role which may be used to override Disease_Has_Associated_Anatomic_Site. The domain and the range for this role are 'Disease, Disorder or Finding' and 'Anatomic Structure, System, or Substance', respectively.
code: R135
Semantic_Type: Conceptual Entity
Display_Name: Excludes Primary Anatomic Site
Preferred_Name: Disease_Excludes_Primary_Anatomic_Site
has exact synonym: Disease_Excludes_Primary_Anatomic_Site

Axiom
annotated source: Disease_Excludes_Primary_Anatomic_Site
annotated property: definition
annotated target: A specializing role which may be used to override Disease_Has_Associated_Anatomic_Site. The domain and the range for this role are 'Disease, Disorder or Finding' and 'Anatomic Structure, System, or Substance', respectively.
def-source: NCI

Axiom
annotated source: Disease_Excludes_Primary_Anatomic_Site
annotated property: has exact synonym
annotated target: Disease_Excludes_Primary_Anatomic_Site
term-group: PT
term-source: NCI

Disease_Excludes_Metastatic_Anatomic_Site
type: ObjectProperty
definition: A specializing role which may be used to override Disease_Has_ Metastatic_Anatomic_Site. The domain and the range for this role are 'Disease, Disorder or Finding' and 'Anatomic Structure, System, or Substance', respectively.
code: R136
Semantic_Type: Conceptual Entity
Display_Name: Excludes Metastatic Anatomic Site
Preferred_Name: Disease_Excludes_Metastatic_Anatomic_Site
has exact synonym: Disease_Excludes_Metastatic_Anatomic_Site

Axiom
annotated source: Disease_Excludes_Metastatic_Anatomic_Site
annotated property: definition
annotated target: A specializing role which may be used to override Disease_Has_ Metastatic_Anatomic_Site. The domain and the range for this role are 'Disease, Disorder or Finding' and 'Anatomic Structure, System, or Substance', respectively.
def-source: NCI

Axiom
annotated source: Disease_Excludes_Metastatic_Anatomic_Site
annotated property: has exact synonym
annotated target: Disease_Excludes_Metastatic_Anatomic_Site
term-group: PT
term-source: NCI

Disease_Excludes_Normal_Tissue_Origin
type: ObjectProperty
definition: A specializing role which may be used to override Disease_Has_Normal_Tissue_Origin. The domain and the range for this role are 'Disease, Disorder or Finding' and 'Anatomic Structure, System, or Substance', respectively.
code: R137
Semantic_Type: Conceptual Entity
Display_Name: Excludes Normal Tissue Origin
Preferred_Name: Disease_Excludes_Normal_Tissue_Origin
has exact synonym: Disease_Excludes_Normal_Tissue_Origin

Axiom
annotated source: Disease_Excludes_Normal_Tissue_Origin
annotated property: definition
annotated target: A specializing role which may be used to override Disease_Has_Normal_Tissue_Origin. The domain and the range for this role are 'Disease, Disorder or Finding' and 'Anatomic Structure, System, or Substance', respectively.
def-source: NCI

Axiom
annotated source: Disease_Excludes_Normal_Tissue_Origin
annotated property: has exact synonym
annotated target: Disease_Excludes_Normal_Tissue_Origin
term-group: PT
term-source: NCI

Disease_Excludes_Normal_Cell_Origin
type: ObjectProperty
definition: A specializing role which may be used to override Disease_Has_Normal_Cell_Origin. The domain and the range for this role are 'Disease, Disorder or Finding' and 'Anatomic Structure, System, or Substance', respectively.
code: R138
Semantic_Type: Conceptual Entity
Display_Name: Excludes Normal Cell Origin
Preferred_Name: Disease_Excludes_Normal_Cell_Origin
has exact synonym: Disease_Excludes_Normal_Cell_Origin

Axiom
annotated source: Disease_Excludes_Normal_Cell_Origin
annotated property: definition
annotated target: A specializing role which may be used to override Disease_Has_Normal_Cell_Origin. The domain and the range for this role are 'Disease, Disorder or Finding' and 'Anatomic Structure, System, or Substance', respectively.
def-source: NCI

Axiom
annotated source: Disease_Excludes_Normal_Cell_Origin
annotated property: has exact synonym
annotated target: Disease_Excludes_Normal_Cell_Origin
term-group: PT
term-source: NCI

Disease_Excludes_Abnormal_Cell
type: ObjectProperty
definition: A specializing role which may be used to override Disease_Has_Abnormal_Cell. The domain and the range for this role are 'Disease, Disorder or Finding' and 'Abnormal Cell', respectively.
code: R139
Semantic_Type: Conceptual Entity
Display_Name: Excludes Abnormal Cell
Preferred_Name: Disease_Excludes_Abnormal_Cell
has exact synonym: Disease_Excludes_Abnormal_Cell

Axiom
annotated source: Disease_Excludes_Abnormal_Cell
annotated property: definition
annotated target: A specializing role which may be used to override Disease_Has_Abnormal_Cell. The domain and the range for this role are 'Disease, Disorder or Finding' and 'Abnormal Cell', respectively.
def-source: NCI

Axiom
annotated source: Disease_Excludes_Abnormal_Cell
annotated property: has exact synonym
annotated target: Disease_Excludes_Abnormal_Cell
term-group: PT
term-source: NCI

Disease_Excludes_Molecular_Abnormality
type: ObjectProperty
definition: A specializing role which may be used to override Disease_Has_ Molecular_Abnormality. The domain and the range for this role are 'Disease, Disorder or Finding' and 'Molecular Abnormality', respectively.
code: R140
Semantic_Type: Conceptual Entity
Display_Name: Excludes Molecular Abnormality
Preferred_Name: Disease_Excludes_Molecular_Abnormality
has exact synonym: Disease_Excludes_Molecular_Abnormality

Axiom
annotated source: Disease_Excludes_Molecular_Abnormality
annotated property: definition
annotated target: A specializing role which may be used to override Disease_Has_ Molecular_Abnormality. The domain and the range for this role are 'Disease, Disorder or Finding' and 'Molecular Abnormality', respectively.
def-source: NCI

Axiom
annotated source: Disease_Excludes_Molecular_Abnormality
annotated property: has exact synonym
annotated target: Disease_Excludes_Molecular_Abnormality
term-group: PT
term-source: NCI

Disease_Excludes_Cytogenetic_Abnormality
type: ObjectProperty
definition: A specializing role which may be used to override Disease_Has_Cytogenetic_Abnormality. The domain and the range for this role are 'Disease, Disorder or Finding' and 'Molecular Abnormality', respectively.
code: R141
Semantic_Type: Conceptual Entity
Display_Name: Excludes Cytogenetic Abnormality
Preferred_Name: Disease_Excludes_Cytogenetic_Abnormality
has exact synonym: Disease_Excludes_Cytogenetic_Abnormality

Axiom
annotated source: Disease_Excludes_Cytogenetic_Abnormality
annotated property: definition
annotated target: A specializing role which may be used to override Disease_Has_Cytogenetic_Abnormality. The domain and the range for this role are 'Disease, Disorder or Finding' and 'Molecular Abnormality', respectively.
def-source: NCI

Axiom
annotated source: Disease_Excludes_Cytogenetic_Abnormality
annotated property: has exact synonym
annotated target: Disease_Excludes_Cytogenetic_Abnormality
term-group: PT
term-source: NCI

Disease_Excludes_Finding
type: ObjectProperty
definition: A specializing role which may be used to override Disease_Has_Finding. Both the domain and range for this role are 'Disease, Disorder or Finding'.
code: R142
Semantic_Type: Conceptual Entity
Display_Name: Excludes Finding
Preferred_Name: Disease_Excludes_Finding
has exact synonym: Disease_Excludes_Finding

Axiom
annotated source: Disease_Excludes_Finding
annotated property: definition
annotated target: A specializing role which may be used to override Disease_Has_Finding. Both the domain and range for this role are 'Disease, Disorder or Finding'.
def-source: NCI

Axiom
annotated source: Disease_Excludes_Finding
annotated property: has exact synonym
annotated target: Disease_Excludes_Finding
term-group: PT
term-source: NCI

Gene_Has_Physical_Location
type: ObjectProperty
definition: A role used to link a gene with its physical extent on a chromosome, denoted by the chromosome number and start and end base positions (with numbering beginning at the telomere of the short p arm). The domain and range for this role are 'Gene' and 'Anatomic Structure, System, or Substance', respectively.
code: R145
Semantic_Type: Conceptual Entity
Display_Name: Has Physical Location
Preferred_Name: Gene_Has_Physical_Location
DesignNote: The standard for the numbering system is that assigned by the Human Genome Consortium and found at Entrez Gene. The role is considered as supplementary to the role Gene_In Chromosomal_Location
has exact synonym: Gene_Has_Physical_Location

Axiom
annotated source: Gene_Has_Physical_Location
annotated property: definition
annotated target: A role used to link a gene with its physical extent on a chromosome, denoted by the chromosome number and start and end base positions (with numbering beginning at the telomere of the short p arm). The domain and range for this role are 'Gene' and 'Anatomic Structure, System, or Substance', respectively.
def-source: NCI

Axiom
annotated source: Gene_Has_Physical_Location
annotated property: has exact synonym
annotated target: Gene_Has_Physical_Location
term-group: PT
term-source: NCI

Chemical_Or_Drug_Affects_Gene_Product
type: ObjectProperty
definition: A role used to assert that a gene product is the target of a therapeutic agent. The role implies a direct interaction between the product and the therapeutic agent but it does not specify the type of association (e.g., involvement, interference, inhibition or cleavage). The domain and range for this role are 'Drug, Food, Chemical or Biomedical Material' and 'Gene Product', respectively.
code: R146
Semantic_Type: Conceptual Entity
Display_Name: Affects Gene Product
Preferred_Name: Chemical_Or_Drug_Affects_Gene_Product
has exact synonym: Chemical_Or_Drug_Affects_Gene_Product

Axiom
annotated source: Chemical_Or_Drug_Affects_Gene_Product
annotated property: definition
annotated target: A role used to assert that a gene product is the target of a therapeutic agent. The role implies a direct interaction between the product and the therapeutic agent but it does not specify the type of association (e.g., involvement, interference, inhibition or cleavage). The domain and range for this role are 'Drug, Food, Chemical or Biomedical Material' and 'Gene Product', respectively.
def-source: NCI

Axiom
annotated source: Chemical_Or_Drug_Affects_Gene_Product
annotated property: has exact synonym
annotated target: Chemical_Or_Drug_Affects_Gene_Product
term-group: PT
term-source: NCI

Chemical_Or_Drug_Affects_Abnormal_Cell
type: ObjectProperty
definition: A role used to establish the relationship between a therapeutic agent and an abnormal cell type associated with a disease condition. By pointing to abnormal cells, the therapeutic target of a drug can be more clearly conveyed. The domain and range for this role are 'Drug, Food, Chemical or Biomedical Material' and 'Abnormal Cell', respectively.
code: R150
Semantic_Type: Conceptual Entity
Display_Name: Affects Abnormal Cell
Preferred_Name: Chemical_Or_Drug_Affects_Abnormal_Cell
has exact synonym: Chemical_Or_Drug_Affects_Abnormal_Cell

Axiom
annotated source: Chemical_Or_Drug_Affects_Abnormal_Cell
annotated property: definition
annotated target: A role used to establish the relationship between a therapeutic agent and an abnormal cell type associated with a disease condition. By pointing to abnormal cells, the therapeutic target of a drug can be more clearly conveyed. The domain and range for this role are 'Drug, Food, Chemical or Biomedical Material' and 'Abnormal Cell', respectively.
def-source: NCI

Axiom
annotated source: Chemical_Or_Drug_Affects_Abnormal_Cell
annotated property: has exact synonym
annotated target: Chemical_Or_Drug_Affects_Abnormal_Cell
term-group: PT
term-source: NCI

Allele_Has_Abnormality
type: ObjectProperty
sub property of: Gene_Has_Abnormality
definition: A specializing role which may be used to override Gene_Has_Abnormality that has been asserted for the gene class. This role is used to establish a link between a specific allele and genetic or molecular abnormalities that have been observed in human cells and tissues associated with cancer or another disease of interest. The domain and range for this role are 'Gene' and 'Molecular Abnormality', respectively.
code: R153
Semantic_Type: Conceptual Entity
Display_Name: Has Abnormality
Preferred_Name: Allele_Has_Abnormality
has exact synonym: Allele_Has_Abnormality

Axiom
annotated source: Allele_Has_Abnormality
annotated property: definition
annotated target: A specializing role which may be used to override Gene_Has_Abnormality that has been asserted for the gene class. This role is used to establish a link between a specific allele and genetic or molecular abnormalities that have been observed in human cells and tissues associated with cancer or another disease of interest. The domain and range for this role are 'Gene' and 'Molecular Abnormality', respectively.
def-source: NCI

Axiom
annotated source: Allele_Has_Abnormality
annotated property: has exact synonym
annotated target: Allele_Has_Abnormality
term-group: PT
term-source: NCI

Allele_In_Chromosomal_Location
type: ObjectProperty
sub property of: Gene_In_Chromosomal_Location
definition: A role used for an allele whose location has changed from the wild-type gene chromosomal location. This role is used to assert a new location that differs from the wild-type gene chromosomal location. The domain and range for this role are 'Gene' and 'Anatomic Structure, System, or Substance', respectively.
code: R155
Semantic_Type: Conceptual Entity
Display_Name: In Chromosomal Location
Preferred_Name: Allele_In_Chromosomal_Location
has exact synonym: Allele_In_Chromosomal_Location

Axiom
annotated source: Allele_In_Chromosomal_Location
annotated property: definition
annotated target: A role used for an allele whose location has changed from the wild-type gene chromosomal location. This role is used to assert a new location that differs from the wild-type gene chromosomal location. The domain and range for this role are 'Gene' and 'Anatomic Structure, System, or Substance', respectively.
def-source: NCI

Axiom
annotated source: Allele_In_Chromosomal_Location
annotated property: has exact synonym
annotated target: Allele_In_Chromosomal_Location
term-group: PT
term-source: NCI

Allele_Absent_From_Wild-type_Chromosomal_Location
type: ObjectProperty
sub property of: Gene_In_Chromosomal_Location
definition: A role used for an allele whose location has changed from the wild-type gene chromosomal location. This role is used to negate an inherited role relationship that is asserted between the parent gene class and a chromosomal location when an allele has moved (e.g., translocation, inversion, etc.). The domain and range for this role are 'Gene' and 'Anatomic Structure, System, or Substance', respectively.
code: R156
Semantic_Type: Conceptual Entity
Display_Name: Absent From Wild-type Chromosomal Location
Preferred_Name: Allele_Absent_From_Wild-type_Chromosomal_Location
has exact synonym: Allele_Absent_From_Wild-type_Chromosomal_Location

Axiom
annotated source: Allele_Absent_From_Wild-type_Chromosomal_Location
annotated property: definition
annotated target: A role used for an allele whose location has changed from the wild-type gene chromosomal location. This role is used to negate an inherited role relationship that is asserted between the parent gene class and a chromosomal location when an allele has moved (e.g., translocation, inversion, etc.). The domain and range for this role are 'Gene' and 'Anatomic Structure, System, or Substance', respectively.
def-source: NCI

Axiom
annotated source: Allele_Absent_From_Wild-type_Chromosomal_Location
annotated property: has exact synonym
annotated target: Allele_Absent_From_Wild-type_Chromosomal_Location
term-group: PT
term-source: NCI

Allele_Plays_Altered_Role_In_Process
type: ObjectProperty
sub property of: Gene_Plays_Role_In_Process
definition: A specializing role which may be used for an allele whose encoded product functions differently (qualitatively or quantitatively) from the function asserted on its parent. It specializes the function of the wild type gene/gene product. The domain and range for this role are 'Gene' and 'Biological Process', respectively.
code: R158
Semantic_Type: Conceptual Entity
Display_Name: Plays Altered Role In Process
Preferred_Name: Allele_Plays_Altered_Role_In_Process
has exact synonym: Allele_Plays_Altered_Role_In_Process

Axiom
annotated source: Allele_Plays_Altered_Role_In_Process
annotated property: definition
annotated target: A specializing role which may be used for an allele whose encoded product functions differently (qualitatively or quantitatively) from the function asserted on its parent. It specializes the function of the wild type gene/gene product. The domain and range for this role are 'Gene' and 'Biological Process', respectively.
def-source: NCI

Axiom
annotated source: Allele_Plays_Altered_Role_In_Process
annotated property: has exact synonym
annotated target: Allele_Plays_Altered_Role_In_Process
term-group: PT
term-source: NCI

Allele_Has_Activity
type: ObjectProperty
definition: A role used to assert the observed level of activity associated with an allele in a given biological process, compared to the wild-type gene. The domain and range for this role are 'Gene' and 'Property or Attribute', respectively.
code: R159
Semantic_Type: Conceptual Entity
Display_Name: Has Activity
Preferred_Name: Allele_Has_Activity
has exact synonym: Allele_Has_Activity

Axiom
annotated source: Allele_Has_Activity
annotated property: definition
annotated target: A role used to assert the observed level of activity associated with an allele in a given biological process, compared to the wild-type gene. The domain and range for this role are 'Gene' and 'Property or Attribute', respectively.
def-source: NCI

Axiom
annotated source: Allele_Has_Activity
annotated property: has exact synonym
annotated target: Allele_Has_Activity
term-group: PT
term-source: NCI

Allele_Plays_Role_In_Metabolism_Of_Chemical_Or_Drug
type: ObjectProperty
definition: A role used to assert a relationship between a specific allele (product; enzyme) and drug-metabolizing efficacy. The domain and range for this role are 'Gene' and 'Drug, Food, Chemical or Biomedical Material', respectively.
code: R160
Semantic_Type: Conceptual Entity
Display_Name: Plays Role In Metabolism Of Chemical Or Drug
Preferred_Name: Allele_Plays_Role_In_Metabolism_Of_Chemical_Or_Drug
has exact synonym: Allele_Plays_Role_In_Metabolism_Of_Chemical_Or_Drug

Axiom
annotated source: Allele_Plays_Role_In_Metabolism_Of_Chemical_Or_Drug
annotated property: definition
annotated target: A role used to assert a relationship between a specific allele (product; enzyme) and drug-metabolizing efficacy. The domain and range for this role are 'Gene' and 'Drug, Food, Chemical or Biomedical Material', respectively.
def-source: NCI

Axiom
annotated source: Allele_Plays_Role_In_Metabolism_Of_Chemical_Or_Drug
annotated property: has exact synonym
annotated target: Allele_Plays_Role_In_Metabolism_Of_Chemical_Or_Drug
term-group: PT
term-source: NCI

Procedure_Has_Target_Anatomy
type: ObjectProperty
definition: A role used to assert a relationship between a procedure and its target anatomy, specifically that a particular procedure always has an association with the target anatomy. This role should be used when a more specific role cannot be asserted, including procedures targeting blood and other fluids. The domain and range for this role are 'Clinical or Research Activity' and 'Anatomic Structure, System, or Substance', respectively.
code: R163
Semantic_Type: Conceptual Entity
Display_Name: Has Target Anatomy
Preferred_Name: Procedure_Has_Target_Anatomy
has exact synonym: Procedure_Has_Target_Anatomy

Axiom
annotated source: Procedure_Has_Target_Anatomy
annotated property: definition
annotated target: A role used to assert a relationship between a procedure and its target anatomy, specifically that a particular procedure always has an association with the target anatomy. This role should be used when a more specific role cannot be asserted, including procedures targeting blood and other fluids. The domain and range for this role are 'Clinical or Research Activity' and 'Anatomic Structure, System, or Substance', respectively.
def-source: NCI

Axiom
annotated source: Procedure_Has_Target_Anatomy
annotated property: has exact synonym
annotated target: Procedure_Has_Target_Anatomy
term-group: PT
term-source: NCI

Procedure_Has_Imaged_Anatomy
type: ObjectProperty
sub property of: Procedure_Has_Target_Anatomy
definition: A role used to assert a relationship between an imaging procedure and its target anatomy, specifically that a particular procedure always involves imaging the specified anatomy. The domain and range for this role are 'Clinical or Research Activity' and 'Anatomic Structure, System, or Substance', respectively.
code: R165
Semantic_Type: Conceptual Entity
Display_Name: Has Imaged Anatomy
Preferred_Name: Procedure_Has_Imaged_Anatomy
has exact synonym: Procedure_Has_Imaged_Anatomy

Axiom
annotated source: Procedure_Has_Imaged_Anatomy
annotated property: definition
annotated target: A role used to assert a relationship between an imaging procedure and its target anatomy, specifically that a particular procedure always involves imaging the specified anatomy. The domain and range for this role are 'Clinical or Research Activity' and 'Anatomic Structure, System, or Substance', respectively.
def-source: NCI

Axiom
annotated source: Procedure_Has_Imaged_Anatomy
annotated property: has exact synonym
annotated target: Procedure_Has_Imaged_Anatomy
term-group: PT
term-source: NCI

Procedure_May_Have_Excised_Anatomy
type: ObjectProperty
sub property of: Procedure_Has_Target_Anatomy
definition: A role used to assert a relationship between a surgical procedure and its target anatomy, specifically that a particular procedure sometimes results in excision of some or all of the specified anatomy. This role is applicable to procedures or techniques that involve excision of solid tissues or organs. It should be used when a more specific role cannot be asserted. The domain and range for this role are 'Clinical or Research Activity' and 'Anatomic Structure, System, or Substance', respectively.
code: R166
Semantic_Type: Conceptual Entity
Display_Name: May Have Excised Anatomy
Preferred_Name: Procedure_May_Have_Excised_Anatomy
has exact synonym: Procedure_May_Have_Excised_Anatomy

Axiom
annotated source: Procedure_May_Have_Excised_Anatomy
annotated property: definition
annotated target: A role used to assert a relationship between a surgical procedure and its target anatomy, specifically that a particular procedure sometimes results in excision of some or all of the specified anatomy. This role is applicable to procedures or techniques that involve excision of solid tissues or organs. It should be used when a more specific role cannot be asserted. The domain and range for this role are 'Clinical or Research Activity' and 'Anatomic Structure, System, or Substance', respectively.
def-source: NCI

Axiom
annotated source: Procedure_May_Have_Excised_Anatomy
annotated property: has exact synonym
annotated target: Procedure_May_Have_Excised_Anatomy
term-group: PT
term-source: NCI

Procedure_Has_Excised_Anatomy
type: ObjectProperty
sub property of: Procedure_May_Have_Excised_Anatomy
definition: A role used to assert a relationship between a surgical procedure and its target anatomy, specifically that a particular procedure always involves excision of some or all of the specified anatomy. This role is applicable to procedures or techniques that involve excision of solid tissues or organs. It should be used when a more specific role cannot be asserted. The domain and range for this role are 'Clinical or Research Activity' and 'Anatomic Structure, System, or Substance', respectively.
code: R167
Semantic_Type: Conceptual Entity
Display_Name: Has Excised Anatomy
Preferred_Name: Procedure_Has_Excised_Anatomy
has exact synonym: Procedure_Has_Excised_Anatomy

Axiom
annotated source: Procedure_Has_Excised_Anatomy
annotated property: definition
annotated target: A role used to assert a relationship between a surgical procedure and its target anatomy, specifically that a particular procedure always involves excision of some or all of the specified anatomy. This role is applicable to procedures or techniques that involve excision of solid tissues or organs. It should be used when a more specific role cannot be asserted. The domain and range for this role are 'Clinical or Research Activity' and 'Anatomic Structure, System, or Substance', respectively.
def-source: NCI

Axiom
annotated source: Procedure_Has_Excised_Anatomy
annotated property: has exact synonym
annotated target: Procedure_Has_Excised_Anatomy
term-group: PT
term-source: NCI

Procedure_May_Have_Partially_Excised_Anatomy
type: ObjectProperty
sub property of: Procedure_Has_Excised_Anatomy
definition: A role used to assert a relationship between a surgical procedure and its target anatomy, specifically that a particular procedure sometimes results in partial excision of the specified anatomy. This role is applicable to procedures or techniques that involve excision of solid tissues or organs, and where partial excision is explicit or can be inferred (e.g. biopsy). The domain and range for this role are 'Clinical or Research Activity' and 'Anatomic Structure, System, or Substance', respectively.
code: R168
Semantic_Type: Conceptual Entity
Display_Name: May Have Partially Excised Anatomy
Preferred_Name: Procedure_May_Have_Partially_Excised_Anatomy
has exact synonym: Procedure_May_Have_Partially_Excised_Anatomy

Axiom
annotated source: Procedure_May_Have_Partially_Excised_Anatomy
annotated property: definition
annotated target: A role used to assert a relationship between a surgical procedure and its target anatomy, specifically that a particular procedure sometimes results in partial excision of the specified anatomy. This role is applicable to procedures or techniques that involve excision of solid tissues or organs, and where partial excision is explicit or can be inferred (e.g. biopsy). The domain and range for this role are 'Clinical or Research Activity' and 'Anatomic Structure, System, or Substance', respectively.
def-source: NCI

Axiom
annotated source: Procedure_May_Have_Partially_Excised_Anatomy
annotated property: has exact synonym
annotated target: Procedure_May_Have_Partially_Excised_Anatomy
term-group: PT
term-source: NCI

Procedure_Has_Partially_Excised_Anatomy
type: ObjectProperty
sub property of: Procedure_May_Have_Partially_Excised_Anatomy
definition: A role used to assert a relationship between a surgical procedure and its target anatomy, specifically that a particular procedure always involves partial excision of the specified anatomy. This role is applicable to procedures or techniques that involve excision of solid tissues or organs, and where partial excision is explicit or can be inferred (e.g. biopsy). The domain and range for this role are 'Clinical or Research Activity' and 'Anatomic Structure, System, or Substance', respectively.
code: R169
Semantic_Type: Conceptual Entity
Display_Name: Has Partially Excised Anatomy
Preferred_Name: Procedure_Has_Partially_Excised_Anatomy
has exact synonym: Procedure_Has_Partially_Excised_Anatomy

Axiom
annotated source: Procedure_Has_Partially_Excised_Anatomy
annotated property: definition
annotated target: A role used to assert a relationship between a surgical procedure and its target anatomy, specifically that a particular procedure always involves partial excision of the specified anatomy. This role is applicable to procedures or techniques that involve excision of solid tissues or organs, and where partial excision is explicit or can be inferred (e.g. biopsy). The domain and range for this role are 'Clinical or Research Activity' and 'Anatomic Structure, System, or Substance', respectively.
def-source: NCI

Axiom
annotated source: Procedure_Has_Partially_Excised_Anatomy
annotated property: has exact synonym
annotated target: Procedure_Has_Partially_Excised_Anatomy
term-group: PT
term-source: NCI

Procedure_May_Have_Completely_Excised_Anatomy
type: ObjectProperty
sub property of: Procedure_Has_Excised_Anatomy
definition: A role used to assert a relationship between a surgical procedure and its target anatomy, specifically that a particular procedure sometimes results in complete excision of the target anatomy. This role is applicable to procedures or techniques that involve excision of solid tissues or organs, and where complete excision is explicit or can be inferred. The domain and range for this role are 'Clinical or Research Activity' and 'Anatomic Structure, System, or Substance', respectively.
code: R170
Semantic_Type: Conceptual Entity
Display_Name: May Have Completely Excised Anatomy
Preferred_Name: Procedure_May_Have_Completely_Excised_Anatomy
has exact synonym: Procedure_May_Have_Completely_Excised_Anatomy

Axiom
annotated source: Procedure_May_Have_Completely_Excised_Anatomy
annotated property: definition
annotated target: A role used to assert a relationship between a surgical procedure and its target anatomy, specifically that a particular procedure sometimes results in complete excision of the target anatomy. This role is applicable to procedures or techniques that involve excision of solid tissues or organs, and where complete excision is explicit or can be inferred. The domain and range for this role are 'Clinical or Research Activity' and 'Anatomic Structure, System, or Substance', respectively.
def-source: NCI

Axiom
annotated source: Procedure_May_Have_Completely_Excised_Anatomy
annotated property: has exact synonym
annotated target: Procedure_May_Have_Completely_Excised_Anatomy
term-group: PT
term-source: NCI

Procedure_Has_Completely_Excised_Anatomy
type: ObjectProperty
sub property of: Procedure_May_Have_Completely_Excised_Anatomy
definition: A role used to assert a relationship between a surgical procedure and its target anatomy, specifically that a particular procedure always is intended for the complete excision of the target anatomy. This role is applicable to procedures or techniques that involve excision of solid tissues or organs, and where complete excision is explicit or can be inferred.. The domain and range for this role are 'Clinical or Research Activity' and 'Anatomic Structure, System, or Substance', respectively.
code: R171
Semantic_Type: Conceptual Entity
Display_Name: Has Completely Excised Anatomy
Preferred_Name: Procedure_Has_Completely_Excised_Anatomy
has exact synonym: Procedure_Has_Completely_Excised_Anatomy

Axiom
annotated source: Procedure_Has_Completely_Excised_Anatomy
annotated property: definition
annotated target: A role used to assert a relationship between a surgical procedure and its target anatomy, specifically that a particular procedure always is intended for the complete excision of the target anatomy. This role is applicable to procedures or techniques that involve excision of solid tissues or organs, and where complete excision is explicit or can be inferred.. The domain and range for this role are 'Clinical or Research Activity' and 'Anatomic Structure, System, or Substance', respectively.
def-source: NCI

Axiom
annotated source: Procedure_Has_Completely_Excised_Anatomy
annotated property: has exact synonym
annotated target: Procedure_Has_Completely_Excised_Anatomy
term-group: PT
term-source: NCI

Regimen_Has_Accepted_Use_For_Disease
type: ObjectProperty
definition: A role used to link established therapeutic regimens to their corresponding cancers or other diseases. Only established regimens published in NCI's Physician Data Query (PDQ), National Comprehensive Cancer Network (NCCN) Guidelines (http://www.nccn.org), or a limited number of other authoritative sources such as the Physician's Cancer Chemotherapy Manual are included. The domain and range for this role are 'Chemotherapy Regimen or Agent Combination' and 'Disease, Disorder or Finding', respectively.
code: R172
Semantic_Type: Conceptual Entity
Display_Name: Has Accepted Use For Disease
Preferred_Name: Regimen_Has_Accepted_Use_For_Disease
has exact synonym: Regimen_Has_Accepted_Use_For_Disease

Axiom
annotated source: Regimen_Has_Accepted_Use_For_Disease
annotated property: definition
annotated target: A role used to link established therapeutic regimens to their corresponding cancers or other diseases. Only established regimens published in NCI's Physician Data Query (PDQ), National Comprehensive Cancer Network (NCCN) Guidelines (http://www.nccn.org), or a limited number of other authoritative sources such as the Physician's Cancer Chemotherapy Manual are included. The domain and range for this role are 'Chemotherapy Regimen or Agent Combination' and 'Disease, Disorder or Finding', respectively.
def-source: NCI

Axiom
annotated source: Regimen_Has_Accepted_Use_For_Disease
annotated property: has exact synonym
annotated target: Regimen_Has_Accepted_Use_For_Disease
term-group: PT
term-source: NCI

Cytogenetic_Abnormality_Involves_Chromosome
type: ObjectProperty
definition: A role used to assert a direct relationship between a cytogenetic abnormality and a chromosome. The domain and range for this role are 'Cytogenetic Abnormality' and 'Chromosome', respectively. The range for this role excludes chromosomal bands and physical locations.
code: R173
Semantic_Type: Conceptual Entity
Preferred_Name: Cytogenetic_Abnormality_Involves_Chromosome
has exact synonym: Cytogenetic_Abnormality_Involves_Chromosome

Axiom
annotated source: Cytogenetic_Abnormality_Involves_Chromosome
annotated property: definition
annotated target: A role used to assert a direct relationship between a cytogenetic abnormality and a chromosome. The domain and range for this role are 'Cytogenetic Abnormality' and 'Chromosome', respectively. The range for this role excludes chromosomal bands and physical locations.
def-source: NCI

Axiom
annotated source: Cytogenetic_Abnormality_Involves_Chromosome
annotated property: has exact synonym
annotated target: Cytogenetic_Abnormality_Involves_Chromosome
term-group: PT
term-source: NCI

Disease_Mapped_To_Chromosome
type: ObjectProperty
definition: A role used to assert a relationship between a disease, disorder or finding and a chromosome. This restriction should be used when a disease or disorder maps to a chromosome. It is not meant to be used when a specific cytogenetic abnormality is known (e.g. translocation, inversion). The domain and range for this role are 'Disease, Disorder or Finding' and 'Chromosome', respectively. The range for this role excludes chromosomal bands and physical locations.
code: R174
Semantic_Type: Conceptual Entity
Preferred_Name: Disease_Mapped_To_Chromosome
has exact synonym: Disease_Mapped_To_Chromosome

Axiom
annotated source: Disease_Mapped_To_Chromosome
annotated property: definition
annotated target: A role used to assert a relationship between a disease, disorder or finding and a chromosome. This restriction should be used when a disease or disorder maps to a chromosome. It is not meant to be used when a specific cytogenetic abnormality is known (e.g. translocation, inversion). The domain and range for this role are 'Disease, Disorder or Finding' and 'Chromosome', respectively. The range for this role excludes chromosomal bands and physical locations.
def-source: NCI

Axiom
annotated source: Disease_Mapped_To_Chromosome
annotated property: has exact synonym
annotated target: Disease_Mapped_To_Chromosome
term-group: PT
term-source: NCI

Gene_Involved_In_Pathogenesis_Of_Disease
type: ObjectProperty
definition: A role used to assert a direct relationship between a gene and a disease. This restriction should only be used when an abnormality in a gene a causative event for a disease. The domain and range for this role are 'Gene' and 'Disease or Disorder', respectively.
code: R175
Semantic_Type: Conceptual Entity
Preferred_Name: Gene_Involved_In_Pathogenesis_Of_Disease
has exact synonym: Gene_Involved_In_Pathogenesis_Of_Disease

Axiom
annotated source: Gene_Involved_In_Pathogenesis_Of_Disease
annotated property: definition
annotated target: A role used to assert a direct relationship between a gene and a disease. This restriction should only be used when an abnormality in a gene a causative event for a disease. The domain and range for this role are 'Gene' and 'Disease or Disorder', respectively.
def-source: NCI

Axiom
annotated source: Gene_Involved_In_Pathogenesis_Of_Disease
annotated property: has exact synonym
annotated target: Gene_Involved_In_Pathogenesis_Of_Disease
term-group: PT
term-source: NCI

Disease_Mapped_To_Gene
type: ObjectProperty
definition: A role used to assert a direct relationship between a disease, disorder or finding and a gene. This restriction can be used when a polymorphism or an abnormality in a gene is either a clinical marker for, a causative event for, or predisposes a subject to a disease. The domain and range for this role are 'Disease, Disorder or Finding' and 'Gene', respectively.
code: R176
Semantic_Type: Conceptual Entity
Preferred_Name: Disease_Mapped_To_Gene
has exact synonym: Disease_Mapped_To_Gene

Axiom
annotated source: Disease_Mapped_To_Gene
annotated property: definition
annotated target: A role used to assert a direct relationship between a disease, disorder or finding and a gene. This restriction can be used when a polymorphism or an abnormality in a gene is either a clinical marker for, a causative event for, or predisposes a subject to a disease. The domain and range for this role are 'Disease, Disorder or Finding' and 'Gene', respectively.
def-source: NCI

Axiom
annotated source: Disease_Mapped_To_Gene
annotated property: has exact synonym
annotated target: Disease_Mapped_To_Gene
term-group: PT
term-source: NCI

Molecular_Abnormality_Involves_Gene
type: ObjectProperty
definition: A role used to assert a direct relationship between a molecular abnormality and a gene. The domain and range for this role are 'Molecular Abnormality' and 'Gene', respectively.
code: R177
Semantic_Type: Conceptual Entity
Preferred_Name: Molecular_Abnormality_Involves_Gene
has exact synonym: Molecular_Abnormality_Involves_Gene

Axiom
annotated source: Molecular_Abnormality_Involves_Gene
annotated property: definition
annotated target: A role used to assert a direct relationship between a molecular abnormality and a gene. The domain and range for this role are 'Molecular Abnormality' and 'Gene', respectively.
def-source: NCI

Axiom
annotated source: Molecular_Abnormality_Involves_Gene
annotated property: has exact synonym
annotated target: Molecular_Abnormality_Involves_Gene
term-group: PT
term-source: NCI

Gene_Mutant_Encodes_Gene_Product_Sequence_Variation
type: ObjectProperty
definition: A role used to indicate that a specific molecular variation or mutation in a gene encodes a gene product sequence variant. The domain and range for this role are 'Gene Mutant' and 'Gene Product Sequence Variation', respectively.
code: R178
Semantic_Type: Conceptual Entity
Preferred_Name: Gene_Mutant_Encodes_Gene_Product_Sequence_Variation
has exact synonym: Gene_Mutant_Encodes_Gene_Product_Sequence_Variation

Axiom
annotated source: Gene_Mutant_Encodes_Gene_Product_Sequence_Variation
annotated property: definition
annotated target: A role used to indicate that a specific molecular variation or mutation in a gene encodes a gene product sequence variant. The domain and range for this role are 'Gene Mutant' and 'Gene Product Sequence Variation', respectively.
def-source: NCI

Axiom
annotated source: Gene_Mutant_Encodes_Gene_Product_Sequence_Variation
annotated property: has exact synonym
annotated target: Gene_Mutant_Encodes_Gene_Product_Sequence_Variation
term-group: PT
term-source: NCI

Gene_Product_Sequence_Variation_Encoded_By_Gene_Mutant
type: ObjectProperty
definition: A role used to indicate that a gene product sequence variation is encoded by a specific gene mutant. The domain and range for this role are 'Gene Product Sequence Variation' and 'Gene Mutant', respectively.
code: R179
Semantic_Type: Conceptual Entity
Preferred_Name: Gene_Product_Sequence_Variation_Encoded_By_Gene_Mutant
has exact synonym: Gene_Product_Sequence_Variation_Encoded_By_Gene_Mutant

Axiom
annotated source: Gene_Product_Sequence_Variation_Encoded_By_Gene_Mutant
annotated property: definition
annotated target: A role used to indicate that a gene product sequence variation is encoded by a specific gene mutant. The domain and range for this role are 'Gene Product Sequence Variation' and 'Gene Mutant', respectively.
def-source: NCI

Axiom
annotated source: Gene_Product_Sequence_Variation_Encoded_By_Gene_Mutant
annotated property: has exact synonym
annotated target: Gene_Product_Sequence_Variation_Encoded_By_Gene_Mutant
term-group: PT
term-source: NCI

Procedure_Has_Target_Disease
type: ObjectProperty
definition: A role used to assert that a procedure or technical method detects, diagnoses, or treats a specified disease state. The domain and range for this role are 'Activity' and 'Disease, Disorder or Finding', respectively.
code: R180
Semantic_Type: Conceptual Entity
Preferred_Name: Procedure_Has_Target_Disease
has exact synonym: Procedure_Has_Target_Disease

Axiom
annotated source: Procedure_Has_Target_Disease
annotated property: definition
annotated target: A role used to assert that a procedure or technical method detects, diagnoses, or treats a specified disease state. The domain and range for this role are 'Activity' and 'Disease, Disorder or Finding', respectively.
def-source: NCI

Axiom
annotated source: Procedure_Has_Target_Disease
annotated property: has exact synonym
annotated target: Procedure_Has_Target_Disease
term-group: PT
term-source: NCI

Procedure_Uses_Manufactured_Object
type: ObjectProperty
definition: A role used to assert that a procedure or technical method requires use of specific artifacts or pieces of equipment. The domain and range for this role are 'Activity' and 'Manufactured Object', respectively.
code: R181
Semantic_Type: Conceptual Entity
Preferred_Name: Procedure_Uses_Manufactured_Object
has exact synonym: Procedure_Uses_Manufactured_Object

Axiom
annotated source: Procedure_Uses_Manufactured_Object
annotated property: definition
annotated target: A role used to assert that a procedure or technical method requires use of specific artifacts or pieces of equipment. The domain and range for this role are 'Activity' and 'Manufactured Object', respectively.
def-source: NCI

Axiom
annotated source: Procedure_Uses_Manufactured_Object
annotated property: has exact synonym
annotated target: Procedure_Uses_Manufactured_Object
term-group: PT
term-source: NCI

Gene_Product_Variant_Of_Gene_Product
type: ObjectProperty
definition: A role used to indicate that a gene product sequence variation is related to a wild-type gene product. The domain and range for this role are 'Gene Product Sequence Variation' and 'Gene Product', respectively.
code: R182
Semantic_Type: Conceptual Entity
Preferred_Name: Gene_Product_Variant_Of_Gene_Product
has exact synonym: Gene_Product_Variant_Of_Gene_Product

Axiom
annotated source: Gene_Product_Variant_Of_Gene_Product
annotated property: definition
annotated target: A role used to indicate that a gene product sequence variation is related to a wild-type gene product. The domain and range for this role are 'Gene Product Sequence Variation' and 'Gene Product', respectively.
def-source: NCI

Axiom
annotated source: Gene_Product_Variant_Of_Gene_Product
annotated property: has exact synonym
annotated target: Gene_Product_Variant_Of_Gene_Product
term-group: PT
term-source: NCI

EO_Disease_Has_Associated_Cell_Type
type: ObjectProperty
definition: A role used to specify the associated cell type of a disease in an experimental organism. The domain and range for this role are 'Experimental Organism Diagnosis' and 'Experimental Organism Anatomical Concept', respectively.
code: R23
Semantic_Type: Conceptual Entity
Display_Name: Has Associated Cell Type
Preferred_Name: EO_Disease_Has_Associated_Cell_Type
has exact synonym: EO_Disease_Has_Associated_Cell_Type

Axiom
annotated source: EO_Disease_Has_Associated_Cell_Type
annotated property: definition
annotated target: A role used to specify the associated cell type of a disease in an experimental organism. The domain and range for this role are 'Experimental Organism Diagnosis' and 'Experimental Organism Anatomical Concept', respectively.
def-source: NCI

Axiom
annotated source: EO_Disease_Has_Associated_Cell_Type
annotated property: has exact synonym
annotated target: EO_Disease_Has_Associated_Cell_Type
term-group: PT
term-source: NCI

EO_Disease_Maps_To_Human_Disease
type: ObjectProperty
definition: A role is used to establish a relationship between a disease in an experimental organism and a corresponding human disease. The domain and the range for this role are 'Experimental Organism Diagnosis' and 'Disease, Disorder or Finding', respectively.
code: R24
Semantic_Type: Conceptual Entity
Display_Name: Maps To Human Disease
Preferred_Name: EO_Disease_Maps_To_Human_Disease
has exact synonym: EO_Disease_Maps_To_Human_Disease

Axiom
annotated source: EO_Disease_Maps_To_Human_Disease
annotated property: definition
annotated target: A role is used to establish a relationship between a disease in an experimental organism and a corresponding human disease. The domain and the range for this role are 'Experimental Organism Diagnosis' and 'Disease, Disorder or Finding', respectively.
def-source: NCI

Axiom
annotated source: EO_Disease_Maps_To_Human_Disease
annotated property: has exact synonym
annotated target: EO_Disease_Maps_To_Human_Disease
term-group: PT
term-source: NCI

EO_Disease_Has_Associated_EO_Anatomy
type: ObjectProperty
definition: A role used to specify the general site, structure or system where a pathological process is located in an experimental organism. The domain and range for this role are 'Experimental Organism Diagnosis' and 'Experimental Organism Anatomical Concept', respectively.
code: R25
Semantic_Type: Conceptual Entity
Display_Name: Has Associated EO Anatomy
Preferred_Name: EO_Disease_Has_Associated_EO_Anatomy
has exact synonym: EO_Disease_Has_Associated_EO_Anatomy

Axiom
annotated source: EO_Disease_Has_Associated_EO_Anatomy
annotated property: definition
annotated target: A role used to specify the general site, structure or system where a pathological process is located in an experimental organism. The domain and range for this role are 'Experimental Organism Diagnosis' and 'Experimental Organism Anatomical Concept', respectively.
def-source: NCI

Axiom
annotated source: EO_Disease_Has_Associated_EO_Anatomy
annotated property: has exact synonym
annotated target: EO_Disease_Has_Associated_EO_Anatomy
term-group: PT
term-source: NCI

EO_Disease_Has_Property_Or_Attribute
type: ObjectProperty
definition: A role used to specify the clinical behavior, or other characteristic, of a disease in an experimental organism. The domain and range for this role are 'Experimental Organism Diagnosis' and 'Property or Attribute', respectively.
code: R26
Semantic_Type: Conceptual Entity
Display_Name: Has Property Or Attribute
Preferred_Name: EO_Disease_Has_Property_Or_Attribute
has exact synonym: EO_Disease_Has_Property_Or_Attribute

Axiom
annotated source: EO_Disease_Has_Property_Or_Attribute
annotated property: definition
annotated target: A role used to specify the clinical behavior, or other characteristic, of a disease in an experimental organism. The domain and range for this role are 'Experimental Organism Diagnosis' and 'Property or Attribute', respectively.
def-source: NCI

Axiom
annotated source: EO_Disease_Has_Property_Or_Attribute
annotated property: has exact synonym
annotated target: EO_Disease_Has_Property_Or_Attribute
term-group: PT
term-source: NCI

Conceptual_Part_Of
type: ObjectProperty
definition: A role used to indicate that a conceptual entity is a sub-entity of another conceptual entity. Both the domain and the range for this role are 'Conceptual Entity'.
code: R27
Semantic_Type: Conceptual Entity
Display_Name: Part Of
Preferred_Name: Conceptual_Part_Of
has exact synonym: Conceptual_Part_Of

Axiom
annotated source: Conceptual_Part_Of
annotated property: definition
annotated target: A role used to indicate that a conceptual entity is a sub-entity of another conceptual entity. Both the domain and the range for this role are 'Conceptual Entity'.
def-source: NCI

Axiom
annotated source: Conceptual_Part_Of
annotated property: has exact synonym
annotated target: Conceptual_Part_Of
term-group: PT
term-source: NCI

Biological_Process_Has_Initiator_Process
type: ObjectProperty
definition: A role used to assert that the initiation of the stated biological process is dependent on the progression or completion of another process. The role implies a direct physical and functional interaction of an element from the preceding biological process with a target molecule or complex involved in the initial stages of the stated process. Both the domain and the range for this role are 'Biological Process'.
code: R28
Semantic_Type: Conceptual Entity
Display_Name: Has Initiator Process
Preferred_Name: Biological_Process_Has_Initiator_Process
has exact synonym: Biological_Process_Has_Initiator_Process

Axiom
annotated source: Biological_Process_Has_Initiator_Process
annotated property: definition
annotated target: A role used to assert that the initiation of the stated biological process is dependent on the progression or completion of another process. The role implies a direct physical and functional interaction of an element from the preceding biological process with a target molecule or complex involved in the initial stages of the stated process. Both the domain and the range for this role are 'Biological Process'.
def-source: NCI

Axiom
annotated source: Biological_Process_Has_Initiator_Process
annotated property: has exact synonym
annotated target: Biological_Process_Has_Initiator_Process
term-group: PT
term-source: NCI

Biological_Process_Has_Result_Chemical_Or_Drug
type: ObjectProperty
definition: A role used to assert that the endpoint of a biological process is the creation of a drug, chemical or biomedical material. The domain and range for this role are 'Biological Process' and 'Drug, Food, Chemical or Biomedical Material', respectively.
code: R29
Semantic_Type: Conceptual Entity
Display_Name: Has Result Chemical Or Drug
Preferred_Name: Biological_Process_Has_Result_Chemical_Or_Drug
has exact synonym: Biological_Process_Has_Result_Chemical_Or_Drug

Axiom
annotated source: Biological_Process_Has_Result_Chemical_Or_Drug
annotated property: definition
annotated target: A role used to assert that the endpoint of a biological process is the creation of a drug, chemical or biomedical material. The domain and range for this role are 'Biological Process' and 'Drug, Food, Chemical or Biomedical Material', respectively.
def-source: NCI

Axiom
annotated source: Biological_Process_Has_Result_Chemical_Or_Drug
annotated property: has exact synonym
annotated target: Biological_Process_Has_Result_Chemical_Or_Drug
term-group: PT
term-source: NCI

Biological_Process_Has_Associated_Location
type: ObjectProperty
definition: A role used to indicate the organ, organ system, cellular or subcellular location where a process occurs in a living system. The domain and range for this role are 'Biological Process' and 'Anatomic Structure, System, or Substance', respectively.
code: R30
Semantic_Type: Conceptual Entity
Display_Name: Has Associated Location
Preferred_Name: Biological_Process_Has_Associated_Location
has exact synonym: Biological_Process_Has_Associated_Location

Axiom
annotated source: Biological_Process_Has_Associated_Location
annotated property: definition
annotated target: A role used to indicate the organ, organ system, cellular or subcellular location where a process occurs in a living system. The domain and range for this role are 'Biological Process' and 'Anatomic Structure, System, or Substance', respectively.
def-source: NCI

Axiom
annotated source: Biological_Process_Has_Associated_Location
annotated property: has exact synonym
annotated target: Biological_Process_Has_Associated_Location
term-group: PT
term-source: NCI

Biological_Process_Has_Result_Anatomy
type: ObjectProperty
definition: A role used to assert that some biological event results in the formation of a subcellular complex, structure, cell, tissue or organ. This role is used to establish this relationship between the biological process and the anatomical factor formed. The domain and range for this role are 'Biological Process' and 'Anatomic Structure, System, or Substance', respectively.
code: R31
Semantic_Type: Conceptual Entity
Display_Name: Has Result Anatomy
Preferred_Name: Biological_Process_Has_Result_Anatomy
has exact synonym: Biological_Process_Has_Result_Anatomy

Axiom
annotated source: Biological_Process_Has_Result_Anatomy
annotated property: definition
annotated target: A role used to assert that some biological event results in the formation of a subcellular complex, structure, cell, tissue or organ. This role is used to establish this relationship between the biological process and the anatomical factor formed. The domain and range for this role are 'Biological Process' and 'Anatomic Structure, System, or Substance', respectively.
def-source: NCI

Axiom
annotated source: Biological_Process_Has_Result_Anatomy
annotated property: has exact synonym
annotated target: Biological_Process_Has_Result_Anatomy
term-group: PT
term-source: NCI

Biological_Process_Has_Initiator_Chemical_Or_Drug
type: ObjectProperty
definition: A role used to assert the relationship between a biological process and a drug or chemical that stimulates the process. The role implies the direct physical interaction of a chemical or drug with a target molecule or complex that results in the initiation of the process. The domain and range for this role are 'Biological Process' and 'Drug, Food, Chemical or Biomedical Material', respectively.
code: R32
Semantic_Type: Conceptual Entity
Display_Name: Has Initiator Chemical Or Drug
Preferred_Name: Biological_Process_Has_Initiator_Chemical_Or_Drug
has exact synonym: Biological_Process_Has_Initiator_Chemical_Or_Drug

Axiom
annotated source: Biological_Process_Has_Initiator_Chemical_Or_Drug
annotated property: definition
annotated target: A role used to assert the relationship between a biological process and a drug or chemical that stimulates the process. The role implies the direct physical interaction of a chemical or drug with a target molecule or complex that results in the initiation of the process. The domain and range for this role are 'Biological Process' and 'Drug, Food, Chemical or Biomedical Material', respectively.
def-source: NCI

Axiom
annotated source: Biological_Process_Has_Initiator_Chemical_Or_Drug
annotated property: has exact synonym
annotated target: Biological_Process_Has_Initiator_Chemical_Or_Drug
term-group: PT
term-source: NCI

Biological_Process_Has_Result_Biological_Process
type: ObjectProperty
definition: A role used to assert that the end result of a biological process initiates a subsequent biological process. Both the domain and the range for this role is 'Biological Process'.
code: R34
Semantic_Type: Conceptual Entity
Display_Name: Has Result Biological Process
Preferred_Name: Biological_Process_Has_Result_Biological_Process
has exact synonym: Biological_Process_Has_Result_Biological_Process

Axiom
annotated source: Biological_Process_Has_Result_Biological_Process
annotated property: definition
annotated target: A role used to assert that the end result of a biological process initiates a subsequent biological process. Both the domain and the range for this role is 'Biological Process'.
def-source: NCI

Axiom
annotated source: Biological_Process_Has_Result_Biological_Process
annotated property: has exact synonym
annotated target: Biological_Process_Has_Result_Biological_Process
term-group: PT
term-source: NCI

Biological_Process_Is_Part_Of_Process
type: ObjectProperty
definition: A role used to assert that a biological process operates as a component of another biological process. Both the domain and the range for this role is 'Biological Process'.
code: R35
Semantic_Type: Conceptual Entity
Display_Name: Is Part Of Process
Preferred_Name: Biological_Process_Is_Part_Of_Process
has exact synonym: Biological_Process_Is_Part_Of_Process

Axiom
annotated source: Biological_Process_Is_Part_Of_Process
annotated property: definition
annotated target: A role used to assert that a biological process operates as a component of another biological process. Both the domain and the range for this role is 'Biological Process'.
def-source: NCI

Axiom
annotated source: Biological_Process_Is_Part_Of_Process
annotated property: has exact synonym
annotated target: Biological_Process_Is_Part_Of_Process
term-group: PT
term-source: NCI

Gene_Is_Biomarker_Type
type: ObjectProperty
definition: A role used to designate the type of biomarker a gene is; it points to a small tree of biomarker types (e.g., Disease Marker, Metabolic Marker, Prognostic Marker). The domain and range for this role are 'Gene' and 'Diagnostic or Prognostic Factor', respectively.
code: R36
Semantic_Type: Conceptual Entity
Display_Name: Is Biomarker Type
Preferred_Name: Gene_Is_Biomarker_Type
has exact synonym: Gene_Is_Biomarker_Type

Axiom
annotated source: Gene_Is_Biomarker_Type
annotated property: has exact synonym
annotated target: Gene_Is_Biomarker_Type
term-group: PT
term-source: NCI

Axiom
annotated source: Gene_Is_Biomarker_Type
annotated property: definition
annotated target: A role used to designate the type of biomarker a gene is; it points to a small tree of biomarker types (e.g., Disease Marker, Metabolic Marker, Prognostic Marker). The domain and range for this role are 'Gene' and 'Diagnostic or Prognostic Factor', respectively.
def-source: NCI

Gene_Plays_Role_In_Process
type: ObjectProperty
definition: A role used to assert a relationship between a gene and a biological process in which its encoded gene product(s) participate. The domain and range for this role are 'Gene' and 'Biological Process', respectively.
code: R37
Semantic_Type: Conceptual Entity
Display_Name: Plays Role In Process
Preferred_Name: Gene_Plays_Role_In_Process
has exact synonym: Gene_Plays_Role_In_Process

Axiom
annotated source: Gene_Plays_Role_In_Process
annotated property: definition
annotated target: A role used to assert a relationship between a gene and a biological process in which its encoded gene product(s) participate. The domain and range for this role are 'Gene' and 'Biological Process', respectively.
def-source: NCI

Axiom
annotated source: Gene_Plays_Role_In_Process
annotated property: has exact synonym
annotated target: Gene_Plays_Role_In_Process
term-group: PT
term-source: NCI

Gene_Associated_With_Disease
type: ObjectProperty
definition: A role used to indicate that molecular abnormalities in a gene may be associated with the manifestation of a disease. The role is used to assert a link between a gene and a disease when the association is considered to have clinical relevance. The domain and range for this role are 'Gene' and 'Disease, Disorder or Finding', respectively.
code: R38
Semantic_Type: Conceptual Entity
Display_Name: Associated With Disease
Preferred_Name: Gene_Associated_With_Disease
has exact synonym: Gene_Associated_With_Disease

Axiom
annotated source: Gene_Associated_With_Disease
annotated property: definition
annotated target: A role used to indicate that molecular abnormalities in a gene may be associated with the manifestation of a disease. The role is used to assert a link between a gene and a disease when the association is considered to have clinical relevance. The domain and range for this role are 'Gene' and 'Disease, Disorder or Finding', respectively.
def-source: NCI

Axiom
annotated source: Gene_Associated_With_Disease
annotated property: has exact synonym
annotated target: Gene_Associated_With_Disease
term-group: PT
term-source: NCI

Gene_Is_Biomarker_Of
type: ObjectProperty
definition: A role used to assert that expression or alteration of a gene is correlated with a particular disease or disease state or is predictive of the disease or disease state. The domain and range for this role are 'Gene' and Findings_and_Disorder_Kind, respectively.
code: R39
Semantic_Type: Conceptual Entity

Axiom
annotated source: Gene_Is_Biomarker_Of
annotated property: definition
annotated target: A role used to assert that expression or alteration of a gene is correlated with a particular disease or disease state or is predictive of the disease or disease state. The domain and range for this role are 'Gene' and Findings_and_Disorder_Kind, respectively.
def-source: NCI

Gene_In_Chromosomal_Location
type: ObjectProperty
definition: A role used to assert a relationship between a gene and its general location, specified by chromosomal band position (infrequently by chromosome number or chromosome arm). The domain and range for this role are 'Gene' and 'Anatomic Structure, System, or Substance', respectively.
code: R40
Semantic_Type: Conceptual Entity
Display_Name: In Chromosomal Location
Preferred_Name: Gene_In_Chromosomal_Location
has exact synonym: Gene_In_Chromosomal_Location

Axiom
annotated source: Gene_In_Chromosomal_Location
annotated property: definition
annotated target: A role used to assert a relationship between a gene and its general location, specified by chromosomal band position (infrequently by chromosome number or chromosome arm). The domain and range for this role are 'Gene' and 'Anatomic Structure, System, or Substance', respectively.
def-source: NCI

Axiom
annotated source: Gene_In_Chromosomal_Location
annotated property: has exact synonym
annotated target: Gene_In_Chromosomal_Location
term-group: PT
term-source: NCI

Gene_Found_In_Organism
type: ObjectProperty
definition: A role used to specify the organism of origin for a gene. It may be used to differentiate genes with the same name and functions that originate from different organisms. The domain and range for this role are 'Gene' and 'Organism', respectively.
code: R41
Semantic_Type: Conceptual Entity
Display_Name: Found In Organism
Preferred_Name: Gene_Found_In_Organism
DesignNote: Currently, we only model human genes, but this role has obvious utility in future, if other organisms are modeled as well.
has exact synonym: Gene_Found_In_Organism

Axiom
annotated source: Gene_Found_In_Organism
annotated property: definition
annotated target: A role used to specify the organism of origin for a gene. It may be used to differentiate genes with the same name and functions that originate from different organisms. The domain and range for this role are 'Gene' and 'Organism', respectively.
def-source: NCI

Axiom
annotated source: Gene_Found_In_Organism
annotated property: has exact synonym
annotated target: Gene_Found_In_Organism
term-group: PT
term-source: NCI

Gene_Product_Is_Biomarker_Type
type: ObjectProperty
definition: A role used to designate the type of biomarker a gene product is; it points to a small tree of biomarker types (e.g., Disease Marker, Metabolic Marker, Prognostic Marker). The domain and range for this role are 'Gene Product' and 'Diagnostic or Prognostic Factor', respectively.
code: R42
Semantic_Type: Conceptual Entity
Display_Name: Is Biomarker Type
Preferred_Name: Gene_Product_Is_Biomarker_Type
has exact synonym: Gene_Product_Is_Biomarker_Type

Axiom
annotated source: Gene_Product_Is_Biomarker_Type
annotated property: definition
annotated target: A role used to designate the type of biomarker a gene product is; it points to a small tree of biomarker types (e.g., Disease Marker, Metabolic Marker, Prognostic Marker). The domain and range for this role are 'Gene Product' and 'Diagnostic or Prognostic Factor', respectively.
def-source: NCI

Axiom
annotated source: Gene_Product_Is_Biomarker_Type
annotated property: has exact synonym
annotated target: Gene_Product_Is_Biomarker_Type
term-group: PT
term-source: NCI

Gene_Product_Has_Chemical_Classification
type: ObjectProperty
definition: A role used to specify the physical structure type of a protein molecule (e.g. metalloprotein, transmembrane protein). Both the domain and range for this role are 'Gene Product'.
code: R44
Semantic_Type: Conceptual Entity
Display_Name: Has Chemical Classification
Preferred_Name: Gene_Product_Has_Chemical_Classification
DesignNote: The role was originally intended for protein structure tagging (e.g., Phosphoprotein, Lipoprotein). Was extended to also tag for Membrane Protein, Protein Complex Subunit, etc.
has exact synonym: Gene_Product_Has_Chemical_Classification

Axiom
annotated source: Gene_Product_Has_Chemical_Classification
annotated property: definition
annotated target: A role used to specify the physical structure type of a protein molecule (e.g. metalloprotein, transmembrane protein). Both the domain and range for this role are 'Gene Product'.
def-source: NCI

Axiom
annotated source: Gene_Product_Has_Chemical_Classification
annotated property: has exact synonym
annotated target: Gene_Product_Has_Chemical_Classification
term-group: PT
term-source: NCI

Gene_Product_Has_Organism_Source
type: ObjectProperty
definition: A role used to differentiate homologous proteins from different organisms. The domain and range for this role are 'Gene Product' and 'Organism', respectively.
code: R45
Semantic_Type: Conceptual Entity
Display_Name: Has Organism Source
Preferred_Name: Gene_Product_Has_Organism_Source
has exact synonym: Gene_Product_Has_Organism_Source

Axiom
annotated source: Gene_Product_Has_Organism_Source
annotated property: definition
annotated target: A role used to differentiate homologous proteins from different organisms. The domain and range for this role are 'Gene Product' and 'Organism', respectively.
def-source: NCI

Axiom
annotated source: Gene_Product_Has_Organism_Source
annotated property: has exact synonym
annotated target: Gene_Product_Has_Organism_Source
term-group: PT
term-source: NCI

Gene_Product_Has_Associated_Anatomy
type: ObjectProperty
definition: A role used to specify physical structures or typical subcellular locations of a gene product. The domain and range for this role are 'Gene Product' and 'Anatomic Structure, System, or Substance', respectively.
code: R46
Semantic_Type: Conceptual Entity
Display_Name: Has Associated Anatomy
Preferred_Name: Gene_Product_Has_Associated_Anatomy
has exact synonym: Gene_Product_Has_Associated_Anatomy

Axiom
annotated source: Gene_Product_Has_Associated_Anatomy
annotated property: definition
annotated target: A role used to specify physical structures or typical subcellular locations of a gene product. The domain and range for this role are 'Gene Product' and 'Anatomic Structure, System, or Substance', respectively.
def-source: NCI

Axiom
annotated source: Gene_Product_Has_Associated_Anatomy
annotated property: has exact synonym
annotated target: Gene_Product_Has_Associated_Anatomy
term-group: PT
term-source: NCI

Gene_Product_Is_Biomarker_Of
type: ObjectProperty
definition: A role used to indicate that presence of a gene product may contribute to clinical diagnosis, treatment selection, or prediction of clinical outcome. The domain and range for this role are 'Gene Product' and 'Disease, Disorder or Finding', respectively.
code: R47
Semantic_Type: Conceptual Entity
Display_Name: Is Biomarker Of
Preferred_Name: Gene_Product_Is_Biomarker_Of
DesignNote: This role does not imply a cause and effect.
has exact synonym: Gene_Product_Is_Biomarker_Of

Axiom
annotated source: Gene_Product_Is_Biomarker_Of
annotated property: definition
annotated target: A role used to indicate that presence of a gene product may contribute to clinical diagnosis, treatment selection, or prediction of clinical outcome. The domain and range for this role are 'Gene Product' and 'Disease, Disorder or Finding', respectively.
def-source: NCI

Axiom
annotated source: Gene_Product_Is_Biomarker_Of
annotated property: has exact synonym
annotated target: Gene_Product_Is_Biomarker_Of
term-group: PT
term-source: NCI

Gene_Product_Malfunction_Associated_With_Disease
type: ObjectProperty
definition: A role used to indicate that molecular abnormalities in a gene product may be associated with the manifestation of a disease. The role is used to assert a link between a gene product and a disease when the association is considered to have clinical relevance. The domain and range for this role are 'Gene Product' and 'Disease, Disorder or Finding', respectively.
code: R48
Semantic_Type: Conceptual Entity
Display_Name: Malfunction Associated With Disease
Preferred_Name: Gene_Product_Malfunction_Associated_With_Disease
has exact synonym: Gene_Product_Malfunction_Associated_With_Disease

Axiom
annotated source: Gene_Product_Malfunction_Associated_With_Disease
annotated property: definition
annotated target: A role used to indicate that molecular abnormalities in a gene product may be associated with the manifestation of a disease. The role is used to assert a link between a gene product and a disease when the association is considered to have clinical relevance. The domain and range for this role are 'Gene Product' and 'Disease, Disorder or Finding', respectively.
def-source: NCI

Axiom
annotated source: Gene_Product_Malfunction_Associated_With_Disease
annotated property: has exact synonym
annotated target: Gene_Product_Malfunction_Associated_With_Disease
term-group: PT
term-source: NCI

Gene_Product_Expressed_In_Tissue
type: ObjectProperty
definition: A role used to specify that a normal tissue is the normal location for the expression of a gene product. The domain and range for this role are 'Gene Product' and 'Anatomic Structure, System, or Substance', respectively.
code: R49
Semantic_Type: Conceptual Entity
Display_Name: Expressed In Tissue
Preferred_Name: Gene_Product_Expressed_In_Tissue
DesignNote: This information is often useful to researchers. However, we no longer curate this information and now favor linking out to externally curated databases. Source database for the link has yet to be decided.
has exact synonym: Gene_Product_Expressed_In_Tissue

Axiom
annotated source: Gene_Product_Expressed_In_Tissue
annotated property: definition
annotated target: A role used to specify that a normal tissue is the normal location for the expression of a gene product. The domain and range for this role are 'Gene Product' and 'Anatomic Structure, System, or Substance', respectively.
def-source: NCI

Axiom
annotated source: Gene_Product_Expressed_In_Tissue
annotated property: has exact synonym
annotated target: Gene_Product_Expressed_In_Tissue
term-group: PT
term-source: NCI

Gene_Product_Has_Structural_Domain_Or_Motif
type: ObjectProperty
definition: A role used specify information about protein domains or motifs present in a protein that can give insight into protein function. The domain and range for this role are 'Gene Product' and 'Anatomic Structure, System, or Substance', respectively.
code: R50
Semantic_Type: Conceptual Entity
Display_Name: Has Structural Domain Or Motif
Preferred_Name: Gene_Product_Has_Structural_Domain_Or_Motif
DesignNote: We no longer curate this information and now favor linking out to externally curated databases. The source database for the link has yet to be decided.
has exact synonym: Gene_Product_Has_Structural_Domain_Or_Motif

Axiom
annotated source: Gene_Product_Has_Structural_Domain_Or_Motif
annotated property: definition
annotated target: A role used specify information about protein domains or motifs present in a protein that can give insight into protein function. The domain and range for this role are 'Gene Product' and 'Anatomic Structure, System, or Substance', respectively.
def-source: NCI

Axiom
annotated source: Gene_Product_Has_Structural_Domain_Or_Motif
annotated property: has exact synonym
annotated target: Gene_Product_Has_Structural_Domain_Or_Motif
term-group: PT
term-source: NCI

Gene_Product_Is_Physical_Part_Of
type: ObjectProperty
definition: A role used to indicate that a gene product normally functions as a component of a "functional complex". Both the domain and range for this role are 'Gene Product'.
code: R51
Semantic_Type: Conceptual Entity
Display_Name: Is Physical Part Of
Preferred_Name: Gene_Product_Is_Physical_Part_Of
has exact synonym: Gene_Product_Is_Physical_Part_Of

Axiom
annotated source: Gene_Product_Is_Physical_Part_Of
annotated property: definition
annotated target: A role used to indicate that a gene product normally functions as a component of a "functional complex". Both the domain and range for this role are 'Gene Product'.
def-source: NCI

Axiom
annotated source: Gene_Product_Is_Physical_Part_Of
annotated property: has exact synonym
annotated target: Gene_Product_Is_Physical_Part_Of
term-group: PT
term-source: NCI

Gene_Product_Has_Biochemical_Function
type: ObjectProperty
definition: A role used to denote the biochemical activity of a gene product. Both the domain and range for this role are 'Gene Product'.
code: R52
Semantic_Type: Conceptual Entity
Display_Name: Has Biochemical Function
Preferred_Name: Gene_Product_Has_Biochemical_Function
has exact synonym: Gene_Product_Has_Biochemical_Function

Axiom
annotated source: Gene_Product_Has_Biochemical_Function
annotated property: definition
annotated target: A role used to denote the biochemical activity of a gene product. Both the domain and range for this role are 'Gene Product'.
def-source: NCI

Axiom
annotated source: Gene_Product_Has_Biochemical_Function
annotated property: has exact synonym
annotated target: Gene_Product_Has_Biochemical_Function
term-group: PT
term-source: NCI

Gene_Product_Plays_Role_In_Biological_Process
type: ObjectProperty
definition: A role used to assert that a gene product participates in a specific biological process. The domain and range for this role are 'Gene Product' and 'Biological Process', respectively.
code: R53
Semantic_Type: Conceptual Entity
Display_Name: Plays Role In Biological Process
Preferred_Name: Gene_Product_Plays_Role_In_Biological_Process
DesignNote: Considered by most researchers to be essential, definitional information about a gene product.
has exact synonym: Gene_Product_Plays_Role_In_Biological_Process

Axiom
annotated source: Gene_Product_Plays_Role_In_Biological_Process
annotated property: definition
annotated target: A role used to assert that a gene product participates in a specific biological process. The domain and range for this role are 'Gene Product' and 'Biological Process', respectively.
def-source: NCI

Axiom
annotated source: Gene_Product_Plays_Role_In_Biological_Process
annotated property: has exact synonym
annotated target: Gene_Product_Plays_Role_In_Biological_Process
term-group: PT
term-source: NCI

Gene_Product_Encoded_By_Gene
type: ObjectProperty
definition: A role used to assert a relationship between a gene product and the gene that encodes it. The domain and range for this role are 'Gene Product' and 'Gene', respectively.
code: R54
Semantic_Type: Conceptual Entity
Display_Name: Encoded By Gene
Preferred_Name: Gene_Product_Encoded_By_Gene
DesignNote: The reciprocal relationship is represented in the property Gene_Encodes_Product
has exact synonym: Gene_Product_Encoded_By_Gene

Axiom
annotated source: Gene_Product_Encoded_By_Gene
annotated property: definition
annotated target: A role used to assert a relationship between a gene product and the gene that encodes it. The domain and range for this role are 'Gene Product' and 'Gene', respectively.
def-source: NCI

Axiom
annotated source: Gene_Product_Encoded_By_Gene
annotated property: has exact synonym
annotated target: Gene_Product_Encoded_By_Gene
term-group: PT
term-source: NCI

Chemical_Or_Drug_Plays_Role_In_Biological_Process
type: ObjectProperty
definition: A role used to assert that an active ingredient of a drug or chemical agent influences a biological process. The role implies a direct association with a target biological molecule or complex involved in the process. The domain and range for this role are 'Drug, Food, Chemical or Biomedical Material' and 'Biological Process', respectively.
code: R66
Semantic_Type: Conceptual Entity
Display_Name: Plays Role In Biological Process
Preferred_Name: Chemical_Or_Drug_Plays_Role_In_Biological_Process
DesignNote: to be deleted
has exact synonym: Chemical_Or_Drug_Plays_Role_In_Biological_Process

Axiom
annotated source: Chemical_Or_Drug_Plays_Role_In_Biological_Process
annotated property: definition
annotated target: A role used to assert that an active ingredient of a drug or chemical agent influences a biological process. The role implies a direct association with a target biological molecule or complex involved in the process. The domain and range for this role are 'Drug, Food, Chemical or Biomedical Material' and 'Biological Process', respectively.
def-source: NCI

Axiom
annotated source: Chemical_Or_Drug_Plays_Role_In_Biological_Process
annotated property: has exact synonym
annotated target: Chemical_Or_Drug_Plays_Role_In_Biological_Process
term-group: PT
term-source: NCI

Chemical_Or_Drug_Affects_Cell_Type_Or_Tissue
type: ObjectProperty
definition: A role used to represent the intended target cells for a chemical or drug. This does not include unintended target cells or tissues that are associated with side effects or toxicity of the chemical or drug. The domain and range for this role are 'Drug, Food, Chemical or Biomedical Material' and 'Anatomic Structure, System, or Substance', respectively.
code: R72
Semantic_Type: Conceptual Entity
Display_Name: Affects Cell Type Or Tissue
Preferred_Name: Chemical_Or_Drug_Affects_Cell_Type_Or_Tissue
has exact synonym: Chemical_Or_Drug_Affects_Cell_Type_Or_Tissue

Axiom
annotated source: Chemical_Or_Drug_Affects_Cell_Type_Or_Tissue
annotated property: definition
annotated target: A role used to represent the intended target cells for a chemical or drug. This does not include unintended target cells or tissues that are associated with side effects or toxicity of the chemical or drug. The domain and range for this role are 'Drug, Food, Chemical or Biomedical Material' and 'Anatomic Structure, System, or Substance', respectively.
def-source: NCI

Axiom
annotated source: Chemical_Or_Drug_Affects_Cell_Type_Or_Tissue
annotated property: has exact synonym
annotated target: Chemical_Or_Drug_Affects_Cell_Type_Or_Tissue
term-group: PT
term-source: NCI

Anatomic_Structure_Has_Location
type: ObjectProperty
type: TransitiveProperty
definition: A role used to indicate the physical location of an anatomic structure in the body. Both the domain and range for this role are 'Anatomic Structure, System, or Substance'.
code: R81
Semantic_Type: Conceptual Entity
Display_Name: Has Location
Preferred_Name: Anatomic_Structure_Has_Location
has exact synonym: Anatomic_Structure_Has_Location

Axiom
annotated source: Anatomic_Structure_Has_Location
annotated property: definition
annotated target: A role used to indicate the physical location of an anatomic structure in the body. Both the domain and range for this role are 'Anatomic Structure, System, or Substance'.
def-source: NCI

Axiom
annotated source: Anatomic_Structure_Has_Location
annotated property: has exact synonym
annotated target: Anatomic_Structure_Has_Location
term-group: PT
term-source: NCI

Anatomic_Structure_Is_Physical_Part_Of
type: ObjectProperty
type: TransitiveProperty
definition: A role used to indicate that an anatomic structure has a physical association with a broader system or organ. Both the domain and range for this role are 'Anatomic Structure, System, or Substance'.
code: R82
Semantic_Type: Conceptual Entity
Display_Name: Is Physical Part Of
Preferred_Name: Anatomic_Structure_Is_Physical_Part_Of
has exact synonym: Anatomic_Structure_Is_Physical_Part_Of

Axiom
annotated source: Anatomic_Structure_Is_Physical_Part_Of
annotated property: definition
annotated target: A role used to indicate that an anatomic structure has a physical association with a broader system or organ. Both the domain and range for this role are 'Anatomic Structure, System, or Substance'.
def-source: NCI

Axiom
annotated source: Anatomic_Structure_Is_Physical_Part_Of
annotated property: has exact synonym
annotated target: Anatomic_Structure_Is_Physical_Part_Of
term-group: PT
term-source: NCI

Disease_Is_Stage
type: ObjectProperty
definition: A role used to specify the disease stage of a disease, the extent to which a cancer has spread from the original site to other parts of the body. The domain and the range for this role are 'Disease, Disorder or Finding' and 'Property or_Attribute', respectively.
code: R88
Semantic_Type: Conceptual Entity
Display_Name: Is Stage
Preferred_Name: Disease_Is_Stage
has exact synonym: Disease_Is_Stage

Axiom
annotated source: Disease_Is_Stage
annotated property: definition
annotated target: A role used to specify the disease stage of a disease, the extent to which a cancer has spread from the original site to other parts of the body. The domain and the range for this role are 'Disease, Disorder or Finding' and 'Property or_Attribute', respectively.
def-source: NCI

Axiom
annotated source: Disease_Is_Stage
annotated property: has exact synonym
annotated target: Disease_Is_Stage
term-group: PT
term-source: NCI

Disease_May_Have_Molecular_Abnormality
type: ObjectProperty
definition: A role used to represent that a molecular abnormality will only be present in some cases of the disease. The domain and the range for this role are 'Disease, Disorder or Finding' and 'Molecular Abnormality', respectively.
code: R89
Semantic_Type: Conceptual Entity
Display_Name: May Have Molecular Abnormality
Preferred_Name: Disease_May_Have_Molecular_Abnormality
has exact synonym: Disease_May_Have_Molecular_Abnormality

Axiom
annotated source: Disease_May_Have_Molecular_Abnormality
annotated property: definition
annotated target: A role used to represent that a molecular abnormality will only be present in some cases of the disease. The domain and the range for this role are 'Disease, Disorder or Finding' and 'Molecular Abnormality', respectively.
def-source: NCI

Axiom
annotated source: Disease_May_Have_Molecular_Abnormality
annotated property: has exact synonym
annotated target: Disease_May_Have_Molecular_Abnormality
term-group: PT
term-source: NCI

High Grade Ovarian Serous Adenocarcinoma
type: Class
subclass of: Ovarian Serous Adenocarcinoma
definition: A rapidly growing serous adenocarcinoma that arises from the ovary. It is characterized by the presence of high grade cytologic features and frequent mitotic figures.
Concept_In_Subset: NCIT C126659
code: C105555
Semantic_Type: Neoplastic Process
Preferred_Name: High Grade Ovarian Serous Adenocarcinoma
UMLS_CUI: C3642254
Neoplastic_Status: Malignant
has exact synonym: High Grade Ovarian Serous Adenocarcinoma
has exact synonym: High-Grade Ovarian Serous Adenocarcinoma
in subset: oncotree slim

Axiom
annotated source: High Grade Ovarian Serous Adenocarcinoma
annotated property: definition
annotated target: A rapidly growing serous adenocarcinoma that arises from the ovary. It is characterized by the presence of high grade cytologic features and frequent mitotic figures.
def-source: NCI

Axiom
annotated source: High Grade Ovarian Serous Adenocarcinoma
annotated property: has exact synonym
annotated target: High Grade Ovarian Serous Adenocarcinoma
term-group: PT
term-source: NCI

Axiom
annotated source: High Grade Ovarian Serous Adenocarcinoma
annotated property: has exact synonym
annotated target: High-Grade Ovarian Serous Adenocarcinoma
term-group: SY
term-source: NCI

Low Grade Ovarian Serous Adenocarcinoma
type: Class
subclass of: Ovarian Serous Adenocarcinoma
definition: A slow-growing serous adenocarcinoma that arises from the ovary. It usually originates from borderline neoplastic processes or adenofibromas. It is characterized by the presence of low grade cytologic features and infrequent mitotic figures.
Concept_In_Subset: NCIT C126659
code: C105556
Semantic_Type: Neoplastic Process
Preferred_Name: Low Grade Ovarian Serous Adenocarcinoma
UMLS_CUI: C3642255
Neoplastic_Status: Malignant
has exact synonym: Low Grade Ovarian Serous Adenocarcinoma
has exact synonym: Low-Grade Ovarian Serous Adenocarcinoma
in subset: oncotree slim

Axiom
annotated source: Low Grade Ovarian Serous Adenocarcinoma
annotated property: definition
annotated target: A slow-growing serous adenocarcinoma that arises from the ovary. It usually originates from borderline neoplastic processes or adenofibromas. It is characterized by the presence of low grade cytologic features and infrequent mitotic figures.
def-source: NCI

Axiom
annotated source: Low Grade Ovarian Serous Adenocarcinoma
annotated property: has exact synonym
annotated target: Low Grade Ovarian Serous Adenocarcinoma
term-group: PT
term-source: NCI

Axiom
annotated source: Low Grade Ovarian Serous Adenocarcinoma
annotated property: has exact synonym
annotated target: Low-Grade Ovarian Serous Adenocarcinoma
term-group: SY
term-source: NCI

Spindle Cell/Sclerosing Rhabdomyosarcoma
type: Class
subclass of: Rhabdomyosarcoma
definition: An uncommon variant of rhabdomyosarcoma with spindle cell or sclerosing morphology. It affects both children and adults and it is more common in males.
Concept_In_Subset: NCIT C126659
code: C121654
Semantic_Type: Neoplastic Process
Preferred_Name: Spindle Cell/Sclerosing Rhabdomyosarcoma
UMLS_CUI: C4053999
Concept_Status: Provisional_Concept
Neoplastic_Status: Malignant
has exact synonym: Spindle Cell/Sclerosing Rhabdomyosarcoma
in subset: oncotree slim

Axiom
annotated source: Spindle Cell/Sclerosing Rhabdomyosarcoma
annotated property: definition
annotated target: An uncommon variant of rhabdomyosarcoma with spindle cell or sclerosing morphology. It affects both children and adults and it is more common in males.
def-source: NCI

Axiom
annotated source: Spindle Cell/Sclerosing Rhabdomyosarcoma
annotated property: has exact synonym
annotated target: Spindle Cell/Sclerosing Rhabdomyosarcoma
term-group: PT
term-source: NCI

Undifferentiated Sarcoma, Not Otherwise Specified
type: Class
definition: An undifferentiated soft tissue sarcoma which cannot be further characterized.
code: C121804
Semantic_Type: Neoplastic Process
Preferred_Name: Undifferentiated Sarcoma, Not Otherwise Specified
UMLS_CUI: C4053897
Neoplastic_Status: Malignant
has exact synonym: Undifferentiated Sarcoma, NOS
has exact synonym: Undifferentiated Sarcoma, Not Otherwise Specified
in subset: oncotree slim

Axiom
annotated source: Undifferentiated Sarcoma, Not Otherwise Specified
annotated property: definition
annotated target: An undifferentiated soft tissue sarcoma which cannot be further characterized.
def-source: NCI

Axiom
annotated source: Undifferentiated Sarcoma, Not Otherwise Specified
annotated property: has exact synonym
annotated target: Undifferentiated Sarcoma, NOS
term-group: SY
term-source: NCI

Axiom
annotated source: Undifferentiated Sarcoma, Not Otherwise Specified
annotated property: has exact synonym
annotated target: Undifferentiated Sarcoma, Not Otherwise Specified
term-group: PT
term-source: NCI

Giant Cell Tumor of Bone
type: Class
definition: A benign but locally aggressive tumor that arises from the bone and is composed of mononuclear cells admixed with macrophages and osteoclast-like giant cells. It usually arises from the ends of long bones or the vertebrae. Clinical presentation includes pain, edema, and decreased range of motion in the affected joint.
Concept_In_Subset: NCIT C61410
Concept_In_Subset: NCIT C77526
Concept_In_Subset: NCIT C88025
code: C121932
Semantic_Type: Neoplastic Process
Preferred_Name: Giant Cell Tumor of Bone
UMLS_CUI: C0206638
Contributing_Source: CDISC
ALT_DEFINITION: A benign neoplasm of bone comprised of giant cells (osteoclast-like) and mononuclear cells.
Neoplastic_Status: Benign
has exact synonym: Benign Bone Giant Cell Tumor
has exact synonym: GIANT CELL TUMOR, BENIGN
has exact synonym: Giant Cell Tumor of Bone
has exact synonym: Giant Cell Tumor of the Bone
has exact synonym: Osteoclastoma
has exact synonym: Osteoclastoma, Benign
in subset: oncotree slim

Axiom
annotated source: Giant Cell Tumor of Bone
annotated property: definition
annotated target: A benign but locally aggressive tumor that arises from the bone and is composed of mononuclear cells admixed with macrophages and osteoclast-like giant cells. It usually arises from the ends of long bones or the vertebrae. Clinical presentation includes pain, edema, and decreased range of motion in the affected joint.
def-source: NCI

Axiom
annotated source: Giant Cell Tumor of Bone
annotated property: ALT_DEFINITION
annotated target: A benign neoplasm of bone comprised of giant cells (osteoclast-like) and mononuclear cells.
def-source: CDISC

Axiom
annotated source: Giant Cell Tumor of Bone
annotated property: has exact synonym
annotated target: Benign Bone Giant Cell Tumor
term-group: SY
term-source: CDISC

Axiom
annotated source: Giant Cell Tumor of Bone
annotated property: has exact synonym
annotated target: GIANT CELL TUMOR, BENIGN
term-group: PT
term-source: CDISC

Axiom
annotated source: Giant Cell Tumor of Bone
annotated property: has exact synonym
annotated target: Giant Cell Tumor of Bone
term-group: PT
term-source: NCI

Axiom
annotated source: Giant Cell Tumor of Bone
annotated property: has exact synonym
annotated target: Giant Cell Tumor of the Bone
term-group: SY
term-source: NCI

Axiom
annotated source: Giant Cell Tumor of Bone
annotated property: has exact synonym
annotated target: Osteoclastoma
term-group: SY
term-source: NCI

Axiom
annotated source: Giant Cell Tumor of Bone
annotated property: has exact synonym
annotated target: Osteoclastoma, Benign
term-group: SY
term-source: CDISC

Borderline Ovarian Serous Tumor-Micropapillary Variant/Non-Invasive Low Grade Ovarian Serous Carcinoma
type: Class
subclass of: Borderline Ovarian Serous Tumor
definition: A non-invasive serous neoplasm that arises from the ovary and shows micropapillary and/or cribriform architectural patterns. It is composed of round epithelial cells with scant cytoplasm and moderate nuclear atypia.
code: C122585
Semantic_Type: Neoplastic Process
Preferred_Name: Borderline Ovarian Serous Tumor-Micropapillary Variant/Non-Invasive Low Grade Ovarian Serous Carcinoma
UMLS_CUI: C4055371
Neoplastic_Status: Malignant
has exact synonym: Borderline Ovarian Serous Tumor-Micropapillary Variant/Non-Invasive Low Grade Ovarian Serous Carcinoma
in subset: oncotree slim

Axiom
annotated source: Borderline Ovarian Serous Tumor-Micropapillary Variant/Non-Invasive Low Grade Ovarian Serous Carcinoma
annotated property: definition
annotated target: A non-invasive serous neoplasm that arises from the ovary and shows micropapillary and/or cribriform architectural patterns. It is composed of round epithelial cells with scant cytoplasm and moderate nuclear atypia.
def-source: NCI

Axiom
annotated source: Borderline Ovarian Serous Tumor-Micropapillary Variant/Non-Invasive Low Grade Ovarian Serous Carcinoma
annotated property: has exact synonym
annotated target: Borderline Ovarian Serous Tumor-Micropapillary Variant/Non-Invasive Low Grade Ovarian Serous Carcinoma
term-group: PT
term-source: NCI

Cervix Uteri
type: Class
subclass of: Restriction
  on property: Anatomic_Structure_Is_Physical_Part_Of
  some values from: Uterus
definition: The lower part of the uterus occupying the region between the isthmus of the uterus and the vagina. It is divided into supravaginal and vaginal portions.
Concept_In_Subset: NCIT C61410
Concept_In_Subset: NCIT C66830
Concept_In_Subset: NCIT C74456
Concept_In_Subset: NCIT C77526
Concept_In_Subset: NCIT C77529
code: C12311
Semantic_Type: Body Part, Organ, or Organ Component
Display_Name: Cervix Uteri
Preferred_Name: Cervix Uteri
UMLS_CUI: C0007874
Contributing_Source: CDISC
ALT_DEFINITION: The lower, narrow end of the uterus that forms a canal between the uterus and vagina.
ALT_DEFINITION: The portion of the uterus (or uterine horns) that empties into the vagina.
Legacy_Concept_Name: Cervix
has exact synonym: CERVIX
has exact synonym: CERVIX UTERI
has exact synonym: Cervix
has exact synonym: Cervix Uteri
has exact synonym: Genital System, Female, Cervix
has exact synonym: Uterine Cervix
has exact synonym: Uterus, Cervix
has exact synonym: cervix
in subset: oncotree slim

Axiom
annotated source: Cervix Uteri
annotated property: definition
annotated target: The lower part of the uterus occupying the region between the isthmus of the uterus and the vagina. It is divided into supravaginal and vaginal portions.
def-source: NCI

Axiom
annotated source: Cervix Uteri
annotated property: ALT_DEFINITION
annotated target: The lower, narrow end of the uterus that forms a canal between the uterus and vagina.
def-source: NCI-GLOSS

Axiom
annotated source: Cervix Uteri
annotated property: ALT_DEFINITION
annotated target: The portion of the uterus (or uterine horns) that empties into the vagina.
def-source: CDISC

Axiom
annotated source: Cervix Uteri
annotated property: has exact synonym
annotated target: CERVIX
term-group: PT
term-source: CDISC
source-code: SEND-SPEC

Axiom
annotated source: Cervix Uteri
annotated property: has exact synonym
annotated target: CERVIX UTERI
term-group: PT
term-source: CDISC
source-code: SDTM-LOC

Axiom
annotated source: Cervix Uteri
annotated property: has exact synonym
annotated target: Cervix
term-group: SY
term-source: NCI

Axiom
annotated source: Cervix Uteri
annotated property: has exact synonym
annotated target: Cervix Uteri
term-group: PT
term-source: NCI

Axiom
annotated source: Cervix Uteri
annotated property: has exact synonym
annotated target: Cervix Uteri
term-group: SY
term-source: CDISC

Axiom
annotated source: Cervix Uteri
annotated property: has exact synonym
annotated target: Cervix Uteri
term-group: SY
term-source: NCI
source-code: TCGA
subsource-name: caDSR

Axiom
annotated source: Cervix Uteri
annotated property: has exact synonym
annotated target: Genital System, Female, Cervix
term-group: SY
term-source: NCI

Axiom
annotated source: Cervix Uteri
annotated property: has exact synonym
annotated target: Uterine Cervix
term-group: SY
term-source: CDISC

Axiom
annotated source: Cervix Uteri
annotated property: has exact synonym
annotated target: Uterine Cervix
term-group: SY
term-source: NCI

Axiom
annotated source: Cervix Uteri
annotated property: has exact synonym
annotated target: Uterus, Cervix
term-group: SY
term-source: NCI

Axiom
annotated source: Cervix Uteri
annotated property: has exact synonym
annotated target: cervix
term-group: PT
term-source: NCI-GLOSS
source-code: CDR0000046133

Mammary Analog Secretory Carcinoma of Salivary Gland
type: Class
subclass of: NCIT C8021
definition: A rare, low-grade carcinoma of the salivary gland with favorable clinical outcome. It usually arises from the parotid gland and less often from the minor salivary glands. It shares the same histopathologic features and molecular characteristics (ETV6 gene rearrangement) with secretory breast carcinoma.
code: C123384
Semantic_Type: Neoplastic Process
Preferred_Name: Mammary Analog Secretory Carcinoma of Salivary Gland
NCI_META_CUI: CL512709
Neoplastic_Status: Malignant
has exact synonym: Mammary Analog Secretory Carcinoma of Salivary Gland
has exact synonym: Salivary Gland MASC
in subset: oncotree slim

Axiom
annotated source: Mammary Analog Secretory Carcinoma of Salivary Gland
annotated property: definition
annotated target: A rare, low-grade carcinoma of the salivary gland with favorable clinical outcome. It usually arises from the parotid gland and less often from the minor salivary glands. It shares the same histopathologic features and molecular characteristics (ETV6 gene rearrangement) with secretory breast carcinoma.
def-source: NCI

Axiom
annotated source: Mammary Analog Secretory Carcinoma of Salivary Gland
annotated property: has exact synonym
annotated target: Mammary Analog Secretory Carcinoma of Salivary Gland
term-group: PT
term-source: NCI

Axiom
annotated source: Mammary Analog Secretory Carcinoma of Salivary Gland
annotated property: has exact synonym
annotated target: Salivary Gland MASC
term-group: SY
term-source: NCI

Bone
type: Class
definition: Connective tissue that forms the skeletal components of the body.
Concept_In_Subset: NCIT C61410
Concept_In_Subset: NCIT C66830
Concept_In_Subset: NCIT C74456
Concept_In_Subset: NCIT C77526
Concept_In_Subset: NCIT C77529
Concept_In_Subset: NCIT C78734
code: C12366
Semantic_Type: Tissue
Display_Name: Bone
Preferred_Name: Bone
UMLS_CUI: C0262950
Contributing_Source: CDISC
ALT_DEFINITION: Calcified connective tissue that forms the skeletal components of the body. (NCI)
Legacy_Concept_Name: Bone
has exact synonym: BONE
has exact synonym: Bone
has exact synonym: Bones
has exact synonym: Osseous
in subset: oncotree slim

Axiom
annotated source: Bone
annotated property: definition
annotated target: Connective tissue that forms the skeletal components of the body.
def-source: NCI

Axiom
annotated source: Bone
annotated property: ALT_DEFINITION
annotated target: Calcified connective tissue that forms the skeletal components of the body. (NCI)
def-source: CDISC

Axiom
annotated source: Bone
annotated property: has exact synonym
annotated target: BONE
term-group: PT
term-source: CDISC

Axiom
annotated source: Bone
annotated property: has exact synonym
annotated target: Bone
term-group: PT
term-source: NCI

Axiom
annotated source: Bone
annotated property: has exact synonym
annotated target: Bone
term-group: SY
term-source: NCI
source-code: TCGA
subsource-name: caDSR

Axiom
annotated source: Bone
annotated property: has exact synonym
annotated target: Bones
term-group: SY
term-source: NCI

Axiom
annotated source: Bone
annotated property: has exact synonym
annotated target: Osseous
term-group: AD
term-source: NCI

Stomach
type: Class
definition: An organ located under the diaphragm, between the liver and the spleen as well as between the esophagus and the small intestine. The stomach is the primary organ of food digestion.
Concept_In_Subset: NCIT C61410
Concept_In_Subset: NCIT C66830
Concept_In_Subset: NCIT C74456
Concept_In_Subset: NCIT C77526
Concept_In_Subset: NCIT C77529
code: C12391
Semantic_Type: Body Part, Organ, or Organ Component
Display_Name: Stomach
Preferred_Name: Stomach
UMLS_CUI: C0038351
Contributing_Source: CDISC
ALT_DEFINITION: An organ that is part of the digestive system. It helps in the digestion of food by mixing it with digestive juices and churning it into a thin liquid.
ALT_DEFINITION: The portion of the gastrointestinal tract located between the esophagus and the proximal duodenum.
Legacy_Concept_Name: Stomach
has exact synonym: Gastric
has exact synonym: Gastrointestinal Tract, Stomach
has exact synonym: STOMACH
has exact synonym: Stomach
has exact synonym: stomach
in subset: oncotree slim

Axiom
annotated source: Stomach
annotated property: definition
annotated target: An organ located under the diaphragm, between the liver and the spleen as well as between the esophagus and the small intestine. The stomach is the primary organ of food digestion.
def-source: NCI

Axiom
annotated source: Stomach
annotated property: ALT_DEFINITION
annotated target: An organ that is part of the digestive system. It helps in the digestion of food by mixing it with digestive juices and churning it into a thin liquid.
def-source: NCI-GLOSS

Axiom
annotated source: Stomach
annotated property: ALT_DEFINITION
annotated target: The portion of the gastrointestinal tract located between the esophagus and the proximal duodenum.
def-source: CDISC

Axiom
annotated source: Stomach
annotated property: has exact synonym
annotated target: Gastric
term-group: AD
term-source: NCI

Axiom
annotated source: Stomach
annotated property: has exact synonym
annotated target: Gastrointestinal Tract, Stomach
term-group: SY
term-source: NCI

Axiom
annotated source: Stomach
annotated property: has exact synonym
annotated target: STOMACH
term-group: PT
term-source: CDISC

Axiom
annotated source: Stomach
annotated property: has exact synonym
annotated target: Stomach
term-group: PT
term-source: NCI

Axiom
annotated source: Stomach
annotated property: has exact synonym
annotated target: Stomach
term-group: SY
term-source: NCI
source-code: TCGA
subsource-name: caDSR

Axiom
annotated source: Stomach
annotated property: has exact synonym
annotated target: stomach
term-group: PT
term-source: NCI-GLOSS
source-code: CDR0000046604

Liver
type: Class
definition: A triangular-shaped organ located under the diaphragm in the right hypochondrium. It is the largest internal organ of the body, weighting up to 2 kg. Metabolism and bile secretion are its main functions. It is composed of cells which have the ability to regenerate.
Concept_In_Subset: NCIT C61410
Concept_In_Subset: NCIT C66830
Concept_In_Subset: NCIT C74456
Concept_In_Subset: NCIT C77526
Concept_In_Subset: NCIT C77529
code: C12392
Semantic_Type: Body Part, Organ, or Organ Component
Display_Name: Liver
Preferred_Name: Liver
UMLS_CUI: C0023884
Contributing_Source: CDISC
ALT_DEFINITION: A large organ located in the upper abdomen. The liver cleanses the blood and aids in digestion by secreting bile.
ALT_DEFINITION: An abdominal organ that has variable lobation which are composed mainly of hepatic lobules.
Legacy_Concept_Name: Liver
has exact synonym: Body System, Hepatic
has exact synonym: Gastrointestinal Tract, Liver
has exact synonym: Hepatic Body System
has exact synonym: Hepatic Organ System
has exact synonym: LIVER
has exact synonym: Liver
has exact synonym: Organ System, Hepatic
has exact synonym: liver
in subset: oncotree slim

Axiom
annotated source: Liver
annotated property: definition
annotated target: A triangular-shaped organ located under the diaphragm in the right hypochondrium. It is the largest internal organ of the body, weighting up to 2 kg. Metabolism and bile secretion are its main functions. It is composed of cells which have the ability to regenerate.
def-source: NCI

Axiom
annotated source: Liver
annotated property: ALT_DEFINITION
annotated target: A large organ located in the upper abdomen. The liver cleanses the blood and aids in digestion by secreting bile.
def-source: NCI-GLOSS

Axiom
annotated source: Liver
annotated property: ALT_DEFINITION
annotated target: An abdominal organ that has variable lobation which are composed mainly of hepatic lobules.
def-source: CDISC

Axiom
annotated source: Liver
annotated property: has exact synonym
annotated target: Body System, Hepatic
term-group: SY
term-source: NCI

Axiom
annotated source: Liver
annotated property: has exact synonym
annotated target: Gastrointestinal Tract, Liver
term-group: SY
term-source: NCI

Axiom
annotated source: Liver
annotated property: has exact synonym
annotated target: Hepatic Body System
term-group: SY
term-source: NCI

Axiom
annotated source: Liver
annotated property: has exact synonym
annotated target: Hepatic Organ System
term-group: SY
term-source: NCI

Axiom
annotated source: Liver
annotated property: has exact synonym
annotated target: LIVER
term-group: PT
term-source: CDISC

Axiom
annotated source: Liver
annotated property: has exact synonym
annotated target: Liver
term-group: PT
term-source: NCI

Axiom
annotated source: Liver
annotated property: has exact synonym
annotated target: Liver
term-group: SY
term-source: NCI
source-code: TCGA
subsource-name: caDSR

Axiom
annotated source: Liver
annotated property: has exact synonym
annotated target: Organ System, Hepatic
term-group: SY
term-source: NCI

Axiom
annotated source: Liver
annotated property: has exact synonym
annotated target: liver
term-group: PT
term-source: NCI-GLOSS
source-code: CDR0000046312

Pancreas
type: Class
definition: An organ behind the lower part of the stomach that is the shape of a fish and about the size of a hand. It is a compound gland composed of both exocrine and endocrine tissues. The endocrine pancreas makes insulin so that the body can use glucose (sugar) for energy. The exocrine pancreas makes enzymes that help the body digest food. Spread all over the pancreas are areas called the Islets of Langerhans. The cells in these areas each have a special purpose. The alpha cells make glucagon, which raises the level of glucose in the blood; the beta cells make insulin; the delta cells make somatostatin. There are also PP cells and D1 cells, about which little is known.
Concept_In_Subset: NCIT C61410
Concept_In_Subset: NCIT C66830
Concept_In_Subset: NCIT C74456
Concept_In_Subset: NCIT C77526
Concept_In_Subset: NCIT C77529
code: C12393
Semantic_Type: Body Part, Organ, or Organ Component
Display_Name: Pancreas
Preferred_Name: Pancreas
UMLS_CUI: C0030274
Contributing_Source: CDISC
ALT_DEFINITION: A digestive organ in the abdomen that has both endocrine and exocrine functions.
ALT_DEFINITION: A glandular organ located in the abdomen. It makes pancreatic juices, which contain enzymes that aid in digestion, and it produces several hormones, including insulin. The pancreas is surrounded by the stomach, intestines, and other organs.
Legacy_Concept_Name: Pancreas
has exact synonym: Gastrointestinal Tract, Pancreas
has exact synonym: PANCREAS
has exact synonym: Pancreas
has exact synonym: pancreas
in subset: oncotree slim

Axiom
annotated source: Pancreas
annotated property: definition
annotated target: An organ behind the lower part of the stomach that is the shape of a fish and about the size of a hand. It is a compound gland composed of both exocrine and endocrine tissues. The endocrine pancreas makes insulin so that the body can use glucose (sugar) for energy. The exocrine pancreas makes enzymes that help the body digest food. Spread all over the pancreas are areas called the Islets of Langerhans. The cells in these areas each have a special purpose. The alpha cells make glucagon, which raises the level of glucose in the blood; the beta cells make insulin; the delta cells make somatostatin. There are also PP cells and D1 cells, about which little is known.
def-source: NCI
attr: from Diabetes Dictionary: http://www.childrenwithdiabetes.com/dictionary

Axiom
annotated source: Pancreas
annotated property: ALT_DEFINITION
annotated target: A digestive organ in the abdomen that has both endocrine and exocrine functions.
def-source: CDISC

Axiom
annotated source: Pancreas
annotated property: ALT_DEFINITION
annotated target: A glandular organ located in the abdomen. It makes pancreatic juices, which contain enzymes that aid in digestion, and it produces several hormones, including insulin. The pancreas is surrounded by the stomach, intestines, and other organs.
def-source: NCI-GLOSS

Axiom
annotated source: Pancreas
annotated property: has exact synonym
annotated target: Gastrointestinal Tract, Pancreas
term-group: SY
term-source: NCI

Axiom
annotated source: Pancreas
annotated property: has exact synonym
annotated target: PANCREAS
term-group: PT
term-source: CDISC

Axiom
annotated source: Pancreas
annotated property: has exact synonym
annotated target: Pancreas
term-group: PT
term-source: NCI

Axiom
annotated source: Pancreas
annotated property: has exact synonym
annotated target: Pancreas
term-group: SY
term-source: NCI
source-code: TCGA
subsource-name: caDSR

Axiom
annotated source: Pancreas
annotated property: has exact synonym
annotated target: pancreas
term-group: PT
term-source: NCI-GLOSS
source-code: CDR0000046254

Thyroid Gland
type: Class
definition: An endocrine gland located at the base of the neck that produces and secretes thyroxine and other hormones. Thyroxine is important for metabolic control.
Concept_In_Subset: NCIT C61410
Concept_In_Subset: NCIT C66830
Concept_In_Subset: NCIT C74456
Concept_In_Subset: NCIT C77526
Concept_In_Subset: NCIT C77529
code: C12400
Semantic_Type: Body Part, Organ, or Organ Component
Display_Name: Thyroid
Preferred_Name: Thyroid Gland
UMLS_CUI: C0040132
Contributing_Source: CDISC
ALT_DEFINITION: A gland located beneath the larynx (voice box) that makes thyroid hormone and calcitonin. The thyroid gland helps regulate growth and metabolism.
ALT_DEFINITION: Endocrine gland(s) adjacent to the trachea in mammals that produce thyroxine and other hormones.
Legacy_Concept_Name: Thyroid_Gland
has exact synonym: GLAND, THYROID
has exact synonym: Head and Neck, Thyroid
has exact synonym: THYROID GLAND
has exact synonym: Thyroid
has exact synonym: Thyroid Gland
has exact synonym: thyroid
has exact synonym: thyroid gland
in subset: oncotree slim

Axiom
annotated source: Thyroid Gland
annotated property: definition
annotated target: An endocrine gland located at the base of the neck that produces and secretes thyroxine and other hormones. Thyroxine is important for metabolic control.
def-source: NCI

Axiom
annotated source: Thyroid Gland
annotated property: ALT_DEFINITION
annotated target: A gland located beneath the larynx (voice box) that makes thyroid hormone and calcitonin. The thyroid gland helps regulate growth and metabolism.
def-source: NCI-GLOSS

Axiom
annotated source: Thyroid Gland
annotated property: ALT_DEFINITION
annotated target: Endocrine gland(s) adjacent to the trachea in mammals that produce thyroxine and other hormones.
def-source: CDISC

Axiom
annotated source: Thyroid Gland
annotated property: has exact synonym
annotated target: GLAND, THYROID
term-group: PT
term-source: CDISC
source-code: SEND-SPEC

Axiom
annotated source: Thyroid Gland
annotated property: has exact synonym
annotated target: Head and Neck, Thyroid
term-group: SY
term-source: NCI

Axiom
annotated source: Thyroid Gland
annotated property: has exact synonym
annotated target: THYROID GLAND
term-group: PT
term-source: CDISC
source-code: SDTM-LOC

Axiom
annotated source: Thyroid Gland
annotated property: has exact synonym
annotated target: Thyroid
term-group: SY
term-source: NCI

Axiom
annotated source: Thyroid Gland
annotated property: has exact synonym
annotated target: Thyroid Gland
term-group: PT
term-source: NCI

Axiom
annotated source: Thyroid Gland
annotated property: has exact synonym
annotated target: Thyroid Gland
term-group: SY
term-source: NCI
source-code: TCGA
subsource-name: caDSR

Axiom
annotated source: Thyroid Gland
annotated property: has exact synonym
annotated target: thyroid
term-group: PT
term-source: NCI-GLOSS
source-code: CDR0000046036

Axiom
annotated source: Thyroid Gland
annotated property: has exact synonym
annotated target: thyroid gland
term-group: PT
term-source: NCI-GLOSS
source-code: CDR0000044751

Eye
type: Class
definition: The organ of sight or vision.
Concept_In_Subset: NCIT C61410
Concept_In_Subset: NCIT C66830
Concept_In_Subset: NCIT C74456
Concept_In_Subset: NCIT C77526
Concept_In_Subset: NCIT C77529
code: C12401
Semantic_Type: Body Part, Organ, or Organ Component
Display_Name: Eye
Preferred_Name: Eye
UMLS_CUI: C0015392
Contributing_Source: CDISC
ALT_DEFINITION: Having to do with the eye.
ALT_DEFINITION: The sensory organ of vision.
Legacy_Concept_Name: Eye
has exact synonym: EYE
has exact synonym: Eye
has exact synonym: Eyeball
has exact synonym: Ocular
has exact synonym: Ophthalmic
has exact synonym: Optic
has exact synonym: ophthalmic
in subset: oncotree slim

Axiom
annotated source: Eye
annotated property: definition
annotated target: The organ of sight or vision.
def-source: NCI

Axiom
annotated source: Eye
annotated property: ALT_DEFINITION
annotated target: Having to do with the eye.
def-source: NCI-GLOSS

Axiom
annotated source: Eye
annotated property: ALT_DEFINITION
annotated target: The sensory organ of vision.
def-source: CDISC

Axiom
annotated source: Eye
annotated property: has exact synonym
annotated target: EYE
term-group: PT
term-source: CDISC

Axiom
annotated source: Eye
annotated property: has exact synonym
annotated target: Eye
term-group: PT
term-source: NCI

Axiom
annotated source: Eye
annotated property: has exact synonym
annotated target: Eye
term-group: SY
term-source: NCI
source-code: TCGA
subsource-name: caDSR

Axiom
annotated source: Eye
annotated property: has exact synonym
annotated target: Eyeball
term-group: SY
term-source: CDISC

Axiom
annotated source: Eye
annotated property: has exact synonym
annotated target: Eyeball
term-group: SY
term-source: NCI

Axiom
annotated source: Eye
annotated property: has exact synonym
annotated target: Ocular
term-group: SY
term-source: NCI

Axiom
annotated source: Eye
annotated property: has exact synonym
annotated target: Ophthalmic
term-group: AD
term-source: NCI

Axiom
annotated source: Eye
annotated property: has exact synonym
annotated target: Optic
term-group: AD
term-source: NCI

Axiom
annotated source: Eye
annotated property: has exact synonym
annotated target: ophthalmic
term-group: PT
term-source: NCI-GLOSS
source-code: CDR0000350235

Ovary
type: Class
definition: One of the paired female reproductive glands containing the ova or germ cells; the ovary's stroma is a vascular connective tissue containing numbers of ovarian follicles enclosing the ova.
Concept_In_Subset: NCIT C61410
Concept_In_Subset: NCIT C66830
Concept_In_Subset: NCIT C74456
Concept_In_Subset: NCIT C77526
Concept_In_Subset: NCIT C77529
code: C12404
Semantic_Type: Body Part, Organ, or Organ Component
Display_Name: Ovary
Preferred_Name: Ovary
UMLS_CUI: C0029939
Contributing_Source: CDISC
ALT_DEFINITION: The female gonad.
ALT_DEFINITION: The pair of female reproductive glands in which the ova, or eggs, are formed. The ovaries are located in the pelvis, one on each side of the uterus.
Legacy_Concept_Name: Ovary
has exact synonym: Genital System, Female, Ovary
has exact synonym: OVARY
has exact synonym: Ovaries
has exact synonym: Ovary
has exact synonym: ovary
in subset: oncotree slim

Axiom
annotated source: Ovary
annotated property: definition
annotated target: One of the paired female reproductive glands containing the ova or germ cells; the ovary's stroma is a vascular connective tissue containing numbers of ovarian follicles enclosing the ova.
def-source: NCI

Axiom
annotated source: Ovary
annotated property: ALT_DEFINITION
annotated target: The female gonad.
def-source: CDISC

Axiom
annotated source: Ovary
annotated property: ALT_DEFINITION
annotated target: The pair of female reproductive glands in which the ova, or eggs, are formed. The ovaries are located in the pelvis, one on each side of the uterus.
def-source: NCI-GLOSS

Axiom
annotated source: Ovary
annotated property: has exact synonym
annotated target: Genital System, Female, Ovary
term-group: SY
term-source: NCI

Axiom
annotated source: Ovary
annotated property: has exact synonym
annotated target: OVARY
term-group: PT
term-source: CDISC

Axiom
annotated source: Ovary
annotated property: has exact synonym
annotated target: Ovaries
term-group: SY
term-source: NCI

Axiom
annotated source: Ovary
annotated property: has exact synonym
annotated target: Ovary
term-group: PT
term-source: NCI

Axiom
annotated source: Ovary
annotated property: has exact synonym
annotated target: Ovary
term-group: SY
term-source: NCI
source-code: TCGA
subsource-name: caDSR

Axiom
annotated source: Ovary
annotated property: has exact synonym
annotated target: ovary
term-group: PT
term-source: NCI-GLOSS
source-code: CDR0000046687

Uterus
type: Class
definition: A hollow, thick-walled, muscular organ located within the pelvic cavity of a woman. Within the uterus the fertilized egg implants and the fetus develops during pregnancy.
Concept_In_Subset: NCIT C61410
Concept_In_Subset: NCIT C66830
Concept_In_Subset: NCIT C74456
Concept_In_Subset: NCIT C77526
Concept_In_Subset: NCIT C77529
code: C12405
Semantic_Type: Body Part, Organ, or Organ Component
Display_Name: Uterus
Preferred_Name: Uterus
UMLS_CUI: C0042149
Contributing_Source: CDISC
ALT_DEFINITION: A hollow muscular organ within which the fertilized egg implants and the embryo/fetus develops during pregnancy.
ALT_DEFINITION: The small, hollow, pear-shaped organ in a woman's pelvis. This is the organ in which a fetus develops.
Legacy_Concept_Name: Uterus
has exact synonym: Genital System, Female, Uterus
has exact synonym: UTERUS
has exact synonym: Uterine
has exact synonym: Utero
has exact synonym: Uterus
has exact synonym: Womb
has exact synonym: uterus
has exact synonym: womb
in subset: oncotree slim

Axiom
annotated source: Uterus
annotated property: definition
annotated target: A hollow, thick-walled, muscular organ located within the pelvic cavity of a woman. Within the uterus the fertilized egg implants and the fetus develops during pregnancy.
def-source: NCI

Axiom
annotated source: Uterus
annotated property: ALT_DEFINITION
annotated target: A hollow muscular organ within which the fertilized egg implants and the embryo/fetus develops during pregnancy.
def-source: CDISC

Axiom
annotated source: Uterus
annotated property: ALT_DEFINITION
annotated target: The small, hollow, pear-shaped organ in a woman's pelvis. This is the organ in which a fetus develops.
def-source: NCI-GLOSS

Axiom
annotated source: Uterus
annotated property: has exact synonym
annotated target: Genital System, Female, Uterus
term-group: SY
term-source: NCI

Axiom
annotated source: Uterus
annotated property: has exact synonym
annotated target: UTERUS
term-group: PT
term-source: CDISC

Axiom
annotated source: Uterus
annotated property: has exact synonym
annotated target: Uterine
term-group: AD
term-source: NCI

Axiom
annotated source: Uterus
annotated property: has exact synonym
annotated target: Utero
term-group: AD
term-source: NCI

Axiom
annotated source: Uterus
annotated property: has exact synonym
annotated target: Uterus
term-group: PT
term-source: NCI

Axiom
annotated source: Uterus
annotated property: has exact synonym
annotated target: Uterus
term-group: SY
term-source: NCI
source-code: TCGA
subsource-name: caDSR

Axiom
annotated source: Uterus
annotated property: has exact synonym
annotated target: Womb
term-group: SY
term-source: CDISC

Axiom
annotated source: Uterus
annotated property: has exact synonym
annotated target: uterus
term-group: PT
term-source: NCI-GLOSS
source-code: CDR0000046645

Axiom
annotated source: Uterus
annotated property: has exact synonym
annotated target: womb
term-group: PT
term-source: NCI-GLOSS
source-code: CDR0000044473

Vulva
type: Class
definition: The external, visible part of the female genitalia surrounding the urethral and vaginal opening. The vulva includes the clitoris and inner as well as outer labia.
Concept_In_Subset: NCIT C61410
Concept_In_Subset: NCIT C66830
Concept_In_Subset: NCIT C74456
Concept_In_Subset: NCIT C77526
Concept_In_Subset: NCIT C77529
code: C12408
Semantic_Type: Body Part, Organ, or Organ Component
Display_Name: Vulva
Preferred_Name: Vulva
UMLS_CUI: C0042993
Contributing_Source: CDISC
ALT_DEFINITION: The external female genital organs, including the clitoris, vaginal lips, and the opening to the vagina.
ALT_DEFINITION: The external, visible part of the female genitalia surrounding the urethral and vaginal opening(s).
Legacy_Concept_Name: Vulva
has exact synonym: External Genitalia
has exact synonym: VULVA
has exact synonym: Vulva
has exact synonym: vulva
in subset: oncotree slim

Axiom
annotated source: Vulva
annotated property: definition
annotated target: The external, visible part of the female genitalia surrounding the urethral and vaginal opening. The vulva includes the clitoris and inner as well as outer labia.
def-source: NCI

Axiom
annotated source: Vulva
annotated property: ALT_DEFINITION
annotated target: The external female genital organs, including the clitoris, vaginal lips, and the opening to the vagina.
def-source: NCI-GLOSS

Axiom
annotated source: Vulva
annotated property: ALT_DEFINITION
annotated target: The external, visible part of the female genitalia surrounding the urethral and vaginal opening(s).
def-source: CDISC

Axiom
annotated source: Vulva
annotated property: has exact synonym
annotated target: External Genitalia
term-group: SY
term-source: NCI

Axiom
annotated source: Vulva
annotated property: has exact synonym
annotated target: VULVA
term-group: PT
term-source: CDISC

Axiom
annotated source: Vulva
annotated property: has exact synonym
annotated target: Vulva
term-group: PT
term-source: NCI

Axiom
annotated source: Vulva
annotated property: has exact synonym
annotated target: Vulva
term-group: SY
term-source: NCI
source-code: TCGA
subsource-name: caDSR

Axiom
annotated source: Vulva
annotated property: has exact synonym
annotated target: vulva
term-group: PT
term-source: NCI-GLOSS
source-code: CDR0000044974

Penis
type: Class
definition: The male organ of urination and copulation.
Concept_In_Subset: NCIT C61410
Concept_In_Subset: NCIT C66830
Concept_In_Subset: NCIT C74456
Concept_In_Subset: NCIT C77526
Concept_In_Subset: NCIT C77529
code: C12409
Semantic_Type: Body Part, Organ, or Organ Component
Display_Name: Penis
Preferred_Name: Penis
UMLS_CUI: C0030851
Contributing_Source: CDISC
ALT_DEFINITION: An external male reproductive organ. It contains a tube called the urethra, which carries semen and urine to the outside of the body.
ALT_DEFINITION: The male organ of urination and copulation. (NCI)
Legacy_Concept_Name: Penis
has exact synonym: Genital System, Male, Penis
has exact synonym: PENIS
has exact synonym: Penis
has exact synonym: penis
in subset: oncotree slim

Axiom
annotated source: Penis
annotated property: definition
annotated target: The male organ of urination and copulation.
def-source: NCI

Axiom
annotated source: Penis
annotated property: ALT_DEFINITION
annotated target: An external male reproductive organ. It contains a tube called the urethra, which carries semen and urine to the outside of the body.
def-source: NCI-GLOSS

Axiom
annotated source: Penis
annotated property: ALT_DEFINITION
annotated target: The male organ of urination and copulation. (NCI)
def-source: CDISC

Axiom
annotated source: Penis
annotated property: has exact synonym
annotated target: Genital System, Male, Penis
term-group: SY
term-source: NCI

Axiom
annotated source: Penis
annotated property: has exact synonym
annotated target: PENIS
term-group: PT
term-source: CDISC

Axiom
annotated source: Penis
annotated property: has exact synonym
annotated target: Penis
term-group: PT
term-source: NCI

Axiom
annotated source: Penis
annotated property: has exact synonym
annotated target: Penis
term-group: SY
term-source: NCI

Axiom
annotated source: Penis
annotated property: has exact synonym
annotated target: Penis
term-group: SY
term-source: NCI
source-code: TCGA
subsource-name: caDSR

Axiom
annotated source: Penis
annotated property: has exact synonym
annotated target: penis
term-group: PT
term-source: NCI-GLOSS
source-code: CDR0000257215

Prostate Gland
type: Class
definition: The walnut shaped accessory sex gland of the male reproductive system. It is located in the pelvis just below the bladder, surrounding the prostatic part of the urethra. The prostate gland secretes a fluid which is part of the semen.
Concept_In_Subset: NCIT C61410
Concept_In_Subset: NCIT C66830
Concept_In_Subset: NCIT C74456
Concept_In_Subset: NCIT C77526
Concept_In_Subset: NCIT C77529
code: C12410
Semantic_Type: Body Part, Organ, or Organ Component
Display_Name: Prostate
Preferred_Name: Prostate Gland
UMLS_CUI: C0033572
Contributing_Source: CDISC
ALT_DEFINITION: A gland in the male reproductive system. The prostate surrounds the part of the urethra (the tube that empties the bladder) just below the bladder, and produces a fluid that forms part of the semen.
ALT_DEFINITION: The male reproductive accessory gland that produces prostatic fluid and is located adjacent to or around the urethra distal to the urinary bladder in mammals.
Legacy_Concept_Name: Prostate_Gland
has exact synonym: GLAND, PROSTATE
has exact synonym: Genital System, Male, Prostate
has exact synonym: PROSTATE GLAND
has exact synonym: Prostate
has exact synonym: Prostate Gland
has exact synonym: Prostatic Gland
has exact synonym: prostate
in subset: oncotree slim

Axiom
annotated source: Prostate Gland
annotated property: definition
annotated target: The walnut shaped accessory sex gland of the male reproductive system. It is located in the pelvis just below the bladder, surrounding the prostatic part of the urethra. The prostate gland secretes a fluid which is part of the semen.
def-source: NCI

Axiom
annotated source: Prostate Gland
annotated property: ALT_DEFINITION
annotated target: A gland in the male reproductive system. The prostate surrounds the part of the urethra (the tube that empties the bladder) just below the bladder, and produces a fluid that forms part of the semen.
def-source: NCI-GLOSS

Axiom
annotated source: Prostate Gland
annotated property: ALT_DEFINITION
annotated target: The male reproductive accessory gland that produces prostatic fluid and is located adjacent to or around the urethra distal to the urinary bladder in mammals.
def-source: CDISC

Axiom
annotated source: Prostate Gland
annotated property: has exact synonym
annotated target: GLAND, PROSTATE
term-group: PT
term-source: CDISC
source-code: SEND-SPEC

Axiom
annotated source: Prostate Gland
annotated property: has exact synonym
annotated target: Genital System, Male, Prostate
term-group: SY
term-source: NCI

Axiom
annotated source: Prostate Gland
annotated property: has exact synonym
annotated target: PROSTATE GLAND
term-group: PT
term-source: CDISC
source-code: SDTM-LOC

Axiom
annotated source: Prostate Gland
annotated property: has exact synonym
annotated target: Prostate
term-group: SY
term-source: NCI

Axiom
annotated source: Prostate Gland
annotated property: has exact synonym
annotated target: Prostate Gland
term-group: PT
term-source: NCI

Axiom
annotated source: Prostate Gland
annotated property: has exact synonym
annotated target: Prostate Gland
term-group: SY
term-source: NCI
source-code: TCGA
subsource-name: caDSR

Axiom
annotated source: Prostate Gland
annotated property: has exact synonym
annotated target: Prostatic Gland
term-group: SY
term-source: NCI

Axiom
annotated source: Prostate Gland
annotated property: has exact synonym
annotated target: prostate
term-group: PT
term-source: NCI-GLOSS
source-code: CDR0000046539

Testis
type: Class
definition: Either of the paired male reproductive glands that produce the male germ cells and the male hormones.
Concept_In_Subset: NCIT C61410
Concept_In_Subset: NCIT C66830
Concept_In_Subset: NCIT C74456
Concept_In_Subset: NCIT C77526
Concept_In_Subset: NCIT C77529
code: C12412
Semantic_Type: Body Part, Organ, or Organ Component
Display_Name: Testis
Preferred_Name: Testis
UMLS_CUI: C0039597
Contributing_Source: CDISC
ALT_DEFINITION: One of two egg-shaped glands inside the scrotum that produce sperm and male hormones.
ALT_DEFINITION: The male gonad.
Legacy_Concept_Name: Testis
has exact synonym: Genital System, Male, Testis
has exact synonym: TESTIS
has exact synonym: Testes
has exact synonym: Testicle
has exact synonym: Testicles
has exact synonym: Testis
has exact synonym: testicle
has exact synonym: testis
in subset: oncotree slim

Axiom
annotated source: Testis
annotated property: definition
annotated target: Either of the paired male reproductive glands that produce the male germ cells and the male hormones.
def-source: NCI

Axiom
annotated source: Testis
annotated property: ALT_DEFINITION
annotated target: One of two egg-shaped glands inside the scrotum that produce sperm and male hormones.
def-source: NCI-GLOSS

Axiom
annotated source: Testis
annotated property: ALT_DEFINITION
annotated target: The male gonad.
def-source: CDISC

Axiom
annotated source: Testis
annotated property: has exact synonym
annotated target: Genital System, Male, Testis
term-group: SY
term-source: NCI

Axiom
annotated source: Testis
annotated property: has exact synonym
annotated target: TESTIS
term-group: PT
term-source: CDISC

Axiom
annotated source: Testis
annotated property: has exact synonym
annotated target: Testes
term-group: SY
term-source: NCI

Axiom
annotated source: Testis
annotated property: has exact synonym
annotated target: Testicle
term-group: SY
term-source: CDISC

Axiom
annotated source: Testis
annotated property: has exact synonym
annotated target: Testicle
term-group: SY
term-source: NCI

Axiom
annotated source: Testis
annotated property: has exact synonym
annotated target: Testicles
term-group: SY
term-source: NCI

Axiom
annotated source: Testis
annotated property: has exact synonym
annotated target: Testis
term-group: PT
term-source: NCI

Axiom
annotated source: Testis
annotated property: has exact synonym
annotated target: Testis
term-group: SY
term-source: NCI
source-code: TCGA
subsource-name: caDSR

Axiom
annotated source: Testis
annotated property: has exact synonym
annotated target: Testis
term-group: SY
term-source: NCI
subsource-name: caDSR

Axiom
annotated source: Testis
annotated property: has exact synonym
annotated target: testicle
term-group: PT
term-source: NCI-GLOSS
source-code: CDR0000046611

Axiom
annotated source: Testis
annotated property: has exact synonym
annotated target: testis
term-group: SY
term-source: NCI-GLOSS
source-code: CDR0000367406

Bladder
type: Class
definition: The distensible sac-like organ that functions as a reservoir of urine, collecting from the kidneys and eliminating via the urethra.
Concept_In_Subset: NCIT C61410
Concept_In_Subset: NCIT C66830
Concept_In_Subset: NCIT C74456
Concept_In_Subset: NCIT C77526
Concept_In_Subset: NCIT C77529
code: C12414
Semantic_Type: Body Part, Organ, or Organ Component
Display_Name: Bladder
Preferred_Name: Bladder
UMLS_CUI: C0005682
Contributing_Source: CDISC
ALT_DEFINITION: The distensible sac-like organ that functions as a reservoir of urine, collecting from the kidneys and eliminating via the urethra. (NCI)
ALT_DEFINITION: The organ that stores urine.
Legacy_Concept_Name: Bladder
has exact synonym: BLADDER
has exact synonym: Bladder
has exact synonym: URINARY BLADDER
has exact synonym: Urinary Bladder
has exact synonym: Urinary System, Bladder
has exact synonym: bladder
in subset: oncotree slim

Axiom
annotated source: Bladder
annotated property: definition
annotated target: The distensible sac-like organ that functions as a reservoir of urine, collecting from the kidneys and eliminating via the urethra.
def-source: NCI

Axiom
annotated source: Bladder
annotated property: ALT_DEFINITION
annotated target: The distensible sac-like organ that functions as a reservoir of urine, collecting from the kidneys and eliminating via the urethra. (NCI)
def-source: CDISC

Axiom
annotated source: Bladder
annotated property: ALT_DEFINITION
annotated target: The organ that stores urine.
def-source: NCI-GLOSS

Axiom
annotated source: Bladder
annotated property: has exact synonym
annotated target: BLADDER
term-group: PT
term-source: CDISC
source-code: SDTM-LOC

Axiom
annotated source: Bladder
annotated property: has exact synonym
annotated target: Bladder
term-group: PT
term-source: NCI

Axiom
annotated source: Bladder
annotated property: has exact synonym
annotated target: Bladder
term-group: SY
term-source: NCI
source-code: TCGA
subsource-name: caDSR

Axiom
annotated source: Bladder
annotated property: has exact synonym
annotated target: URINARY BLADDER
term-group: PT
term-source: CDISC
source-code: SEND-SPEC

Axiom
annotated source: Bladder
annotated property: has exact synonym
annotated target: Urinary Bladder
term-group: SY
term-source: NCI

Axiom
annotated source: Bladder
annotated property: has exact synonym
annotated target: Urinary System, Bladder
term-group: SY
term-source: NCI

Axiom
annotated source: Bladder
annotated property: has exact synonym
annotated target: bladder
term-group: PT
term-source: NCI-GLOSS
source-code: CDR0000046501

Kidney
type: Class
definition: One of the two bean-shaped organs located on each side of the spine in the retroperitoneum. The right kidney is located below the liver and the left kidney below the diaphragm. The kidneys filter and secret the metabolic products and minerals from the blood, thus maintaining the homeostasis. On the superior pole of each kidney there is an adrenal gland. Each kidney and adrenal gland is surrounded by fat.
Concept_In_Subset: NCIT C61410
Concept_In_Subset: NCIT C66830
Concept_In_Subset: NCIT C74456
Concept_In_Subset: NCIT C77526
Concept_In_Subset: NCIT C77529
code: C12415
Semantic_Type: Body Part, Organ, or Organ Component
Display_Name: Kidney
Preferred_Name: Kidney
UMLS_CUI: C0022646
Contributing_Source: CDISC
ALT_DEFINITION: One of a pair of organs in the abdomen. Kidneys remove waste from the blood (as urine), produce erythropoietin (a substance that stimulates red blood cell production), and play a role in blood pressure regulation.
ALT_DEFINITION: The organs of the urinary tract located in the retroperitoneal cavity adjacent to the spine and composed of the renal cortex and the renal medulla.
Legacy_Concept_Name: Kidney
has exact synonym: KIDNEY
has exact synonym: Kidney
has exact synonym: Kidneys
has exact synonym: Urinary System, Kidney
has exact synonym: kidney
in subset: oncotree slim

Axiom
annotated source: Kidney
annotated property: definition
annotated target: One of the two bean-shaped organs located on each side of the spine in the retroperitoneum. The right kidney is located below the liver and the left kidney below the diaphragm. The kidneys filter and secret the metabolic products and minerals from the blood, thus maintaining the homeostasis. On the superior pole of each kidney there is an adrenal gland. Each kidney and adrenal gland is surrounded by fat.
def-source: NCI

Axiom
annotated source: Kidney
annotated property: ALT_DEFINITION
annotated target: One of a pair of organs in the abdomen. Kidneys remove waste from the blood (as urine), produce erythropoietin (a substance that stimulates red blood cell production), and play a role in blood pressure regulation.
def-source: NCI-GLOSS

Axiom
annotated source: Kidney
annotated property: ALT_DEFINITION
annotated target: The organs of the urinary tract located in the retroperitoneal cavity adjacent to the spine and composed of the renal cortex and the renal medulla.
def-source: CDISC

Axiom
annotated source: Kidney
annotated property: has exact synonym
annotated target: KIDNEY
term-group: PT
term-source: CDISC

Axiom
annotated source: Kidney
annotated property: has exact synonym
annotated target: Kidney
term-group: PT
term-source: NCI

Axiom
annotated source: Kidney
annotated property: has exact synonym
annotated target: Kidney
term-group: SY
term-source: NCI
source-code: TCGA
subsource-name: caDSR

Axiom
annotated source: Kidney
annotated property: has exact synonym
annotated target: Kidneys
term-group: SY
term-source: NCI

Axiom
annotated source: Kidney
annotated property: has exact synonym
annotated target: Urinary System, Kidney
term-group: SY
term-source: NCI

Axiom
annotated source: Kidney
annotated property: has exact synonym
annotated target: kidney
term-group: PT
term-source: NCI-GLOSS
source-code: CDR0000046325

Head and Neck
type: Class
definition: For oncology, an area of the body generally construed to comprise the base of skull and facial bones, sinuses, orbits, salivary glands, oral cavity, oropharynx, larynx, thyroid, facial and neck musculature and lymph nodes draining these areas.
Concept_In_Subset: NCIT C61410
Concept_In_Subset: NCIT C66830
Concept_In_Subset: NCIT C74456
Concept_In_Subset: NCIT C77526
code: C12418
Semantic_Type: Body Location or Region
Display_Name: Head and Neck
Preferred_Name: Head and Neck
UMLS_CUI: C0460004
Contributing_Source: CDISC
ALT_DEFINITION: The area of the body comprising the skull, facial bones and the cervical vertebrae, sinuses, orbits, salivary glands, oral cavity, oropharynx, larynx, thyroid, facial and neck musculature, soft tissue and lymph nodes draining these areas.
Legacy_Concept_Name: Head_and_Neck
has exact synonym: H and N
has exact synonym: HEAD AND NECK
has exact synonym: Head and Neck
in subset: oncotree slim

Axiom
annotated source: Head and Neck
annotated property: definition
annotated target: For oncology, an area of the body generally construed to comprise the base of skull and facial bones, sinuses, orbits, salivary glands, oral cavity, oropharynx, larynx, thyroid, facial and neck musculature and lymph nodes draining these areas.
def-source: NCI

Axiom
annotated source: Head and Neck
annotated property: ALT_DEFINITION
annotated target: The area of the body comprising the skull, facial bones and the cervical vertebrae, sinuses, orbits, salivary glands, oral cavity, oropharynx, larynx, thyroid, facial and neck musculature, soft tissue and lymph nodes draining these areas.
def-source: CDISC

Axiom
annotated source: Head and Neck
annotated property: has exact synonym
annotated target: H and N
term-group: SY
term-source: NCI

Axiom
annotated source: Head and Neck
annotated property: has exact synonym
annotated target: HEAD AND NECK
term-group: PT
term-source: CDISC

Axiom
annotated source: Head and Neck
annotated property: has exact synonym
annotated target: Head and Neck
term-group: PT
term-source: NCI

Axiom
annotated source: Head and Neck
annotated property: has exact synonym
annotated target: Head and Neck
term-group: SY
term-source: NCI
source-code: TCGA
subsource-name: caDSR

Thymus Gland
type: Class
definition: A bi-lobed organ surrounded by a connective tissue capsule. It is located in the upper anterior portion of the chest, behind the sternum. It is composed predominantly of lymphocytes and fewer epithelial cells. Connective tissue septa separate the lobes into lobules. The lobules contain an outer portion (cortical zone) which is rich in lymphocytes and an inner portion (medullary zone) which is rich in epithelial cells. It is an organ essential for the development of the immune system. Its function is the maturation of the progenitor lymphoid cells to thymocytes and subsequently to mature T-cells. It reaches its greatest weight at puberty and subsequently begins to involute.
Concept_In_Subset: NCIT C61410
Concept_In_Subset: NCIT C66830
Concept_In_Subset: NCIT C74456
Concept_In_Subset: NCIT C77526
Concept_In_Subset: NCIT C77529
code: C12433
Semantic_Type: Body Part, Organ, or Organ Component
Display_Name: Thymus Gland
Preferred_Name: Thymus Gland
UMLS_CUI: C0040113
Contributing_Source: CDISC
ALT_DEFINITION: A primary lymphoid organ generally located in the mediastinum near the thoracic inlet and/or along lateral aspects of the neck.
ALT_DEFINITION: An organ that is part of the lymphatic system, in which T lymphocytes grow and multiply. The thymus is in the chest behind the breastbone.
Legacy_Concept_Name: Thymus_Gland
has exact synonym: Reticuloendothelial System, Thymus
has exact synonym: THYMUS
has exact synonym: THYMUS GLAND
has exact synonym: Thymus
has exact synonym: Thymus Gland
has exact synonym: thymus
in subset: oncotree slim

Axiom
annotated source: Thymus Gland
annotated property: definition
annotated target: A bi-lobed organ surrounded by a connective tissue capsule. It is located in the upper anterior portion of the chest, behind the sternum. It is composed predominantly of lymphocytes and fewer epithelial cells. Connective tissue septa separate the lobes into lobules. The lobules contain an outer portion (cortical zone) which is rich in lymphocytes and an inner portion (medullary zone) which is rich in epithelial cells. It is an organ essential for the development of the immune system. Its function is the maturation of the progenitor lymphoid cells to thymocytes and subsequently to mature T-cells. It reaches its greatest weight at puberty and subsequently begins to involute.
def-source: NCI

Axiom
annotated source: Thymus Gland
annotated property: ALT_DEFINITION
annotated target: A primary lymphoid organ generally located in the mediastinum near the thoracic inlet and/or along lateral aspects of the neck.
def-source: CDISC

Axiom
annotated source: Thymus Gland
annotated property: ALT_DEFINITION
annotated target: An organ that is part of the lymphatic system, in which T lymphocytes grow and multiply. The thymus is in the chest behind the breastbone.
def-source: NCI-GLOSS

Axiom
annotated source: Thymus Gland
annotated property: has exact synonym
annotated target: Reticuloendothelial System, Thymus
term-group: SY
term-source: NCI

Axiom
annotated source: Thymus Gland
annotated property: has exact synonym
annotated target: THYMUS
term-group: PT
term-source: CDISC
source-code: SEND-SPEC

Axiom
annotated source: Thymus Gland
annotated property: has exact synonym
annotated target: THYMUS GLAND
term-group: PT
term-source: CDISC
source-code: SDTM-LOC

Axiom
annotated source: Thymus Gland
annotated property: has exact synonym
annotated target: Thymus
term-group: SY
term-source: NCI

Axiom
annotated source: Thymus Gland
annotated property: has exact synonym
annotated target: Thymus Gland
term-group: PT
term-source: NCI

Axiom
annotated source: Thymus Gland
annotated property: has exact synonym
annotated target: Thymus Gland
term-group: SY
term-source: CDISC

Axiom
annotated source: Thymus Gland
annotated property: has exact synonym
annotated target: Thymus Gland
term-group: SY
term-source: NCI

Axiom
annotated source: Thymus Gland
annotated property: has exact synonym
annotated target: Thymus Gland
term-group: SY
term-source: NCI
source-code: TCGA
subsource-name: caDSR

Axiom
annotated source: Thymus Gland
annotated property: has exact synonym
annotated target: thymus
term-group: PT
term-source: NCI-GLOSS
source-code: CDR0000046616

Blood
type: Class
definition: A liquid tissue; its major function is to transport oxygen throughout the body. It also supplies the tissues with nutrients, removes waste products, and contains various components of the immune system defending the body against infection. Several hormones also travel in the blood.
Concept_In_Subset: NCIT C61410
Concept_In_Subset: NCIT C66830
Concept_In_Subset: NCIT C74456
Concept_In_Subset: NCIT C77526
Concept_In_Subset: NCIT C78734
code: C12434
Semantic_Type: Body Substance
Display_Name: Blood
Preferred_Name: Blood
UMLS_CUI: C0005767
Contributing_Source: CDISC
ALT_DEFINITION: A liquid tissue with the primary function of transporting oxygen and carbon dioxide. It supplies the tissues with nutrients, removes waste products, and contains various components of the immune system defending the body against infection.
ALT_DEFINITION: A tissue with red blood cells, white blood cells, platelets, and other substances suspended in fluid called plasma. Blood takes oxygen and nutrients to the tissues, and carries away wastes.
Legacy_Concept_Name: Blood
has exact synonym: BLOOD
has exact synonym: Blood
has exact synonym: Peripheral Blood
has exact synonym: Reticuloendothelial System, Blood
has exact synonym: Whole Blood
has exact synonym: blood
has exact synonym: peripheral blood
in subset: oncotree slim

Axiom
annotated source: Blood
annotated property: definition
annotated target: A liquid tissue; its major function is to transport oxygen throughout the body. It also supplies the tissues with nutrients, removes waste products, and contains various components of the immune system defending the body against infection. Several hormones also travel in the blood.
def-source: NCI

Axiom
annotated source: Blood
annotated property: ALT_DEFINITION
annotated target: A liquid tissue with the primary function of transporting oxygen and carbon dioxide. It supplies the tissues with nutrients, removes waste products, and contains various components of the immune system defending the body against infection.
def-source: CDISC

Axiom
annotated source: Blood
annotated property: ALT_DEFINITION
annotated target: A tissue with red blood cells, white blood cells, platelets, and other substances suspended in fluid called plasma. Blood takes oxygen and nutrients to the tissues, and carries away wastes.
def-source: NCI-GLOSS

Axiom
annotated source: Blood
annotated property: has exact synonym
annotated target: BLOOD
term-group: PT
term-source: CDISC

Axiom
annotated source: Blood
annotated property: has exact synonym
annotated target: Blood
term-group: PT
term-source: NCI

Axiom
annotated source: Blood
annotated property: has exact synonym
annotated target: Blood
term-group: SY
term-source: NCI
source-code: TCGA
subsource-name: caDSR

Axiom
annotated source: Blood
annotated property: has exact synonym
annotated target: Peripheral Blood
term-group: SY
term-source: CDISC

Axiom
annotated source: Blood
annotated property: has exact synonym
annotated target: Peripheral Blood
term-group: SY
term-source: NCI

Axiom
annotated source: Blood
annotated property: has exact synonym
annotated target: Reticuloendothelial System, Blood
term-group: SY
term-source: NCI

Axiom
annotated source: Blood
annotated property: has exact synonym
annotated target: Whole Blood
term-group: SY
term-source: CDISC

Axiom
annotated source: Blood
annotated property: has exact synonym
annotated target: blood
term-group: PT
term-source: NCI-GLOSS
source-code: CDR0000270735

Axiom
annotated source: Blood
annotated property: has exact synonym
annotated target: peripheral blood
term-group: PT
term-source: NCI-GLOSS
source-code: CDR0000046011

Central Nervous System
type: Class
definition: The part of the nervous system that consists of the brain, spinal cord, and meninges.
Concept_In_Subset: NCIT C61410
Concept_In_Subset: NCIT C66830
Concept_In_Subset: NCIT C74456
Concept_In_Subset: NCIT C77526
code: C12438
Semantic_Type: Body System
Display_Name: Central Nervous System
Preferred_Name: Central Nervous System
UMLS_CUI: C3714787
Contributing_Source: CDISC
ALT_DEFINITION: The brain and spinal cord.
ALT_DEFINITION: The part of the nervous system that consists of the brain, spinal cord, and meninges. (NCI)
Legacy_Concept_Name: Central_Nervous_System
has exact synonym: CENTRAL NERVOUS SYSTEM
has exact synonym: CNS
has exact synonym: Central Nervous System
has exact synonym: Nervous System, CNS
has exact synonym: central nervous system
in subset: oncotree slim

Axiom
annotated source: Central Nervous System
annotated property: definition
annotated target: The part of the nervous system that consists of the brain, spinal cord, and meninges.
def-source: NCI

Axiom
annotated source: Central Nervous System
annotated property: ALT_DEFINITION
annotated target: The brain and spinal cord.
def-source: NCI-GLOSS

Axiom
annotated source: Central Nervous System
annotated property: ALT_DEFINITION
annotated target: The part of the nervous system that consists of the brain, spinal cord, and meninges. (NCI)
def-source: CDISC

Axiom
annotated source: Central Nervous System
annotated property: has exact synonym
annotated target: CENTRAL NERVOUS SYSTEM
term-group: PT
term-source: CDISC

Axiom
annotated source: Central Nervous System
annotated property: has exact synonym
annotated target: CNS
term-group: PT
term-source: NCI-GLOSS
source-code: CDR0000045643

Axiom
annotated source: Central Nervous System
annotated property: has exact synonym
annotated target: CNS
term-group: SY
term-source: NCI

Axiom
annotated source: Central Nervous System
annotated property: has exact synonym
annotated target: Central Nervous System
term-group: PT
term-source: NCI

Axiom
annotated source: Central Nervous System
annotated property: has exact synonym
annotated target: Central Nervous System
term-group: SY
term-source: NCI
source-code: TCGA
subsource-name: caDSR

Axiom
annotated source: Central Nervous System
annotated property: has exact synonym
annotated target: Nervous System, CNS
term-group: SY
term-source: NCI

Axiom
annotated source: Central Nervous System
annotated property: has exact synonym
annotated target: central nervous system
term-group: PT
term-source: NCI-GLOSS
source-code: CDR0000046481

Peripheral Nervous System
type: Class
definition: That part of the nervous system consisting of the nerves and neurons that reside or extend outside the central nervous system.
code: C12465
Semantic_Type: Body System
Display_Name: Peripheral Nervous System
Preferred_Name: Peripheral Nervous System
UMLS_CUI: C0206417
Legacy_Concept_Name: Peripheral_Nervous_System
has exact synonym: Peripheral Nervous System
in subset: oncotree slim

Axiom
annotated source: Peripheral Nervous System
annotated property: definition
annotated target: That part of the nervous system consisting of the nerves and neurons that reside or extend outside the central nervous system.
def-source: NCI

Axiom
annotated source: Peripheral Nervous System
annotated property: has exact synonym
annotated target: Peripheral Nervous System
term-group: PT
term-source: NCI

Lung
type: Class
definition: One of a pair of viscera occupying the pulmonary cavities of the thorax, the organs of respiration in which aeration of the blood takes place. As a rule, the right lung is slightly larger than the left and is divided into three lobes (an upper, a middle, and a lower or basal), while the left has two lobes (an upper and a lower or basal). Each lung is irregularly conical in shape, presenting a blunt upper extremity (the apex), a concave base following the curve of the diaphragm, an outer convex surface (costal surface), an inner or mediastinal surface (mediastinal surface), a thin and sharp anterior border, and a thick and rounded posterior border.
Concept_In_Subset: NCIT C61410
Concept_In_Subset: NCIT C66830
Concept_In_Subset: NCIT C74456
Concept_In_Subset: NCIT C77526
Concept_In_Subset: NCIT C77529
code: C12468
Semantic_Type: Body Part, Organ, or Organ Component
Display_Name: Lung
Preferred_Name: Lung
UMLS_CUI: C0024109
Contributing_Source: CDISC
ALT_DEFINITION: A thoracic organ that has variable lobation and is the primary respiratory organ of mammals.
ALT_DEFINITION: One of a pair of organs in the chest that supplies the body with oxygen, and removes carbon dioxide from the body.
Legacy_Concept_Name: Lung
has exact synonym: LUNG
has exact synonym: Lung
has exact synonym: Lungs
has exact synonym: Respiratory System, Lung
has exact synonym: lung
in subset: oncotree slim

Axiom
annotated source: Lung
annotated property: definition
annotated target: One of a pair of viscera occupying the pulmonary cavities of the thorax, the organs of respiration in which aeration of the blood takes place. As a rule, the right lung is slightly larger than the left and is divided into three lobes (an upper, a middle, and a lower or basal), while the left has two lobes (an upper and a lower or basal). Each lung is irregularly conical in shape, presenting a blunt upper extremity (the apex), a concave base following the curve of the diaphragm, an outer convex surface (costal surface), an inner or mediastinal surface (mediastinal surface), a thin and sharp anterior border, and a thick and rounded posterior border.
def-source: NCI

Axiom
annotated source: Lung
annotated property: ALT_DEFINITION
annotated target: A thoracic organ that has variable lobation and is the primary respiratory organ of mammals.
def-source: CDISC

Axiom
annotated source: Lung
annotated property: ALT_DEFINITION
annotated target: One of a pair of organs in the chest that supplies the body with oxygen, and removes carbon dioxide from the body.
def-source: NCI-GLOSS

Axiom
annotated source: Lung
annotated property: has exact synonym
annotated target: LUNG
term-group: PT
term-source: CDISC

Axiom
annotated source: Lung
annotated property: has exact synonym
annotated target: Lung
term-group: PT
term-source: NCI

Axiom
annotated source: Lung
annotated property: has exact synonym
annotated target: Lung
term-group: SY
term-source: NCI
source-code: TCGA
subsource-name: caDSR

Axiom
annotated source: Lung
annotated property: has exact synonym
annotated target: Lungs
term-group: SY
term-source: NCI

Axiom
annotated source: Lung
annotated property: has exact synonym
annotated target: Respiratory System, Lung
term-group: SY
term-source: NCI

Axiom
annotated source: Lung
annotated property: has exact synonym
annotated target: lung
term-group: PT
term-source: NCI-GLOSS
source-code: CDR0000270740

Pleura
type: Class
definition: The tissue that lines the wall of the thoracic cavity and the surface of the lungs.
Concept_In_Subset: NCIT C61410
Concept_In_Subset: NCIT C66830
Concept_In_Subset: NCIT C74456
Concept_In_Subset: NCIT C77526
Concept_In_Subset: NCIT C77529
code: C12469
Semantic_Type: Tissue
Preferred_Name: Pleura
UMLS_CUI: C0032225
Contributing_Source: CDISC
ALT_DEFINITION: A thin layer of tissue that covers the lungs and lines the interior wall of the chest cavity. It protects and cushions the lungs. This tissue secretes a small amount of fluid that acts as a lubricant, allowing the lungs to move smoothly in the chest cavity while breathing.
ALT_DEFINITION: The serous membrane that lines the wall of the thoracic cavity and the surface of the lungs.
Legacy_Concept_Name: Pleural_Tissue
has exact synonym: PLEURA
has exact synonym: Pleura
has exact synonym: Pleural Tissue
has exact synonym: pleura
in subset: oncotree slim

Axiom
annotated source: Pleura
annotated property: definition
annotated target: The tissue that lines the wall of the thoracic cavity and the surface of the lungs.
def-source: NCI

Axiom
annotated source: Pleura
annotated property: ALT_DEFINITION
annotated target: A thin layer of tissue that covers the lungs and lines the interior wall of the chest cavity. It protects and cushions the lungs. This tissue secretes a small amount of fluid that acts as a lubricant, allowing the lungs to move smoothly in the chest cavity while breathing.
def-source: NCI-GLOSS

Axiom
annotated source: Pleura
annotated property: ALT_DEFINITION
annotated target: The serous membrane that lines the wall of the thoracic cavity and the surface of the lungs.
def-source: CDISC

Axiom
annotated source: Pleura
annotated property: has exact synonym
annotated target: PLEURA
term-group: PT
term-source: CDISC

Axiom
annotated source: Pleura
annotated property: has exact synonym
annotated target: Pleura
term-group: PT
term-source: NCI

Axiom
annotated source: Pleura
annotated property: has exact synonym
annotated target: Pleura
term-group: SY
term-source: NCI
source-code: TCGA
subsource-name: caDSR

Axiom
annotated source: Pleura
annotated property: has exact synonym
annotated target: Pleural Tissue
term-group: SY
term-source: NCI

Axiom
annotated source: Pleura
annotated property: has exact synonym
annotated target: pleura
term-group: PT
term-source: NCI-GLOSS
source-code: CDR0000045842

Soft Tissue
type: Class
Concept_In_Subset: NCIT C61410
Concept_In_Subset: NCIT C66830
Concept_In_Subset: NCIT C78734
code: C12471
Semantic_Type: Tissue
Display_Name: Soft Tissue
Preferred_Name: Soft Tissue
UMLS_CUI: C0225317
Contributing_Source: CDISC
ALT_DEFINITION: Refers to muscle, fat, fibrous tissue, blood vessels or other supporting tissue of the body.
ALT_DEFINITION: Refers to muscle, fat, fibrous tissue, blood vessels, or other supporting tissue of the body.
Legacy_Concept_Name: Soft_Tissue
has exact synonym: SOFT TISSUE
has exact synonym: Soft Tissue
has exact synonym: soft tissue
in subset: oncotree slim

Axiom
annotated source: Soft Tissue
annotated property: ALT_DEFINITION
annotated target: Refers to muscle, fat, fibrous tissue, blood vessels or other supporting tissue of the body.
def-source: CDISC

Axiom
annotated source: Soft Tissue
annotated property: ALT_DEFINITION
annotated target: Refers to muscle, fat, fibrous tissue, blood vessels, or other supporting tissue of the body.
def-source: NCI-GLOSS

Axiom
annotated source: Soft Tissue
annotated property: has exact synonym
annotated target: SOFT TISSUE
term-group: PT
term-source: CDISC

Axiom
annotated source: Soft Tissue
annotated property: has exact synonym
annotated target: Soft Tissue
term-group: PT
term-source: NCI

Axiom
annotated source: Soft Tissue
annotated property: has exact synonym
annotated target: Soft Tissue
term-group: SY
term-source: CDISC

Axiom
annotated source: Soft Tissue
annotated property: has exact synonym
annotated target: Soft Tissue
term-group: SY
term-source: NCI
source-code: TCGA
subsource-name: caDSR

Axiom
annotated source: Soft Tissue
annotated property: has exact synonym
annotated target: soft tissue
term-group: PT
term-source: NCI-GLOSS
source-code: CDR0000045882

Adrenal Gland
type: Class
subclass of: Restriction
  on property: Anatomic_Structure_Has_Location
  some values from: Kidney
definition: A flattened, roughly triangular body resting upon the upper end of each kidney; it is one of the ductless glands furnishing internal secretions (epinephrine and norepinephrine from the medulla and steroid hormones from the cortex).
Concept_In_Subset: NCIT C61410
Concept_In_Subset: NCIT C66830
Concept_In_Subset: NCIT C74456
Concept_In_Subset: NCIT C77526
Concept_In_Subset: NCIT C77529
code: C12666
Semantic_Type: Body Part, Organ, or Organ Component
Display_Name: Adrenal Gland
Preferred_Name: Adrenal Gland
UMLS_CUI: C0001625
Contributing_Source: CDISC
ALT_DEFINITION: A small gland that makes steroid hormones, adrenaline, and noradrenaline. These hormones help control heart rate, blood pressure, and other important body functions. There are two adrenal glands, one on top of each kidney.
ALT_DEFINITION: The endocrine glands adjacent to the kidneys that consist of the outer adrenal cortex and the inner adrenal medulla in mammals.
Legacy_Concept_Name: Adrenal_Gland
has exact synonym: ADRENAL GLAND
has exact synonym: Adrenal Gland
has exact synonym: Adrenal Glands
has exact synonym: Adrenals
has exact synonym: GLAND, ADRENAL
has exact synonym: adrenal gland
has exact synonym: suprarenal gland
in subset: oncotree slim

Axiom
annotated source: Adrenal Gland
annotated property: definition
annotated target: A flattened, roughly triangular body resting upon the upper end of each kidney; it is one of the ductless glands furnishing internal secretions (epinephrine and norepinephrine from the medulla and steroid hormones from the cortex).
def-source: NCI

Axiom
annotated source: Adrenal Gland
annotated property: ALT_DEFINITION
annotated target: A small gland that makes steroid hormones, adrenaline, and noradrenaline. These hormones help control heart rate, blood pressure, and other important body functions. There are two adrenal glands, one on top of each kidney.
def-source: NCI-GLOSS

Axiom
annotated source: Adrenal Gland
annotated property: ALT_DEFINITION
annotated target: The endocrine glands adjacent to the kidneys that consist of the outer adrenal cortex and the inner adrenal medulla in mammals.
def-source: CDISC

Axiom
annotated source: Adrenal Gland
annotated property: has exact synonym
annotated target: ADRENAL GLAND
term-group: PT
term-source: CDISC
source-code: SDTM-LOC

Axiom
annotated source: Adrenal Gland
annotated property: has exact synonym
annotated target: Adrenal Gland
term-group: PT
term-source: NCI

Axiom
annotated source: Adrenal Gland
annotated property: has exact synonym
annotated target: Adrenal Gland
term-group: SY
term-source: NCI
source-code: TCGA
subsource-name: caDSR

Axiom
annotated source: Adrenal Gland
annotated property: has exact synonym
annotated target: Adrenal Glands
term-group: SY
term-source: NCI

Axiom
annotated source: Adrenal Gland
annotated property: has exact synonym
annotated target: Adrenals
term-group: SY
term-source: NCI

Axiom
annotated source: Adrenal Gland
annotated property: has exact synonym
annotated target: GLAND, ADRENAL
term-group: PT
term-source: CDISC
source-code: SEND-SPEC

Axiom
annotated source: Adrenal Gland
annotated property: has exact synonym
annotated target: adrenal gland
term-group: PT
term-source: NCI-GLOSS
source-code: CDR0000046678

Axiom
annotated source: Adrenal Gland
annotated property: has exact synonym
annotated target: suprarenal gland
term-group: PT
term-source: NCI-GLOSS
source-code: CDR0000458086

Biliary Tract
type: Class
definition: The system that transports bile from the hepatocytes in the liver to the small intestine. It is comprised of the intrahepatic bile ducts, hepatic ducts, common bile duct, cystic duct, and the gallbladder.
Concept_In_Subset: NCIT C61410
Concept_In_Subset: NCIT C66830
Concept_In_Subset: NCIT C74456
Concept_In_Subset: NCIT C77526
code: C12678
Semantic_Type: Body Part, Organ, or Organ Component
Display_Name: Biliary Tract
Preferred_Name: Biliary Tract
UMLS_CUI: C0005423
Contributing_Source: CDISC
ALT_DEFINITION: The duct system that transports bile from its origination by hepatocytes in the liver to the small intestine. It is comprised of the common bile duct that connects the liver and gall bladder to the small intestine and the cystic duct that connects the gall bladder to the common bile duct. (NCI)
ALT_DEFINITION: The organs and ducts that make and store bile (a fluid made by the liver that helps digest fat), and release it into the small intestine. The biliary tract includes the gallbladder and bile ducts inside and outside the liver.
Legacy_Concept_Name: Biliary_Tract
has exact synonym: BILIARY TRACT
has exact synonym: Bile Tract
has exact synonym: Biliary System
has exact synonym: Biliary Tract
has exact synonym: Tract, Biliary
has exact synonym: biliary system
has exact synonym: biliary tract
in subset: oncotree slim

Axiom
annotated source: Biliary Tract
annotated property: definition
annotated target: The system that transports bile from the hepatocytes in the liver to the small intestine. It is comprised of the intrahepatic bile ducts, hepatic ducts, common bile duct, cystic duct, and the gallbladder.
def-source: NCI

Axiom
annotated source: Biliary Tract
annotated property: ALT_DEFINITION
annotated target: The duct system that transports bile from its origination by hepatocytes in the liver to the small intestine. It is comprised of the common bile duct that connects the liver and gall bladder to the small intestine and the cystic duct that connects the gall bladder to the common bile duct. (NCI)
def-source: CDISC

Axiom
annotated source: Biliary Tract
annotated property: ALT_DEFINITION
annotated target: The organs and ducts that make and store bile (a fluid made by the liver that helps digest fat), and release it into the small intestine. The biliary tract includes the gallbladder and bile ducts inside and outside the liver.
def-source: NCI-GLOSS

Axiom
annotated source: Biliary Tract
annotated property: has exact synonym
annotated target: BILIARY TRACT
term-group: PT
term-source: CDISC

Axiom
annotated source: Biliary Tract
annotated property: has exact synonym
annotated target: Bile Tract
term-group: SY
term-source: NCI

Axiom
annotated source: Biliary Tract
annotated property: has exact synonym
annotated target: Biliary System
term-group: SY
term-source: NCI

Axiom
annotated source: Biliary Tract
annotated property: has exact synonym
annotated target: Biliary Tract
term-group: PT
term-source: NCI

Axiom
annotated source: Biliary Tract
annotated property: has exact synonym
annotated target: Biliary Tract
term-group: SY
term-source: CDISC

Axiom
annotated source: Biliary Tract
annotated property: has exact synonym
annotated target: Tract, Biliary
term-group: SY
term-source: NCI

Axiom
annotated source: Biliary Tract
annotated property: has exact synonym
annotated target: biliary system
term-group: PT
term-source: NCI-GLOSS
source-code: CDR0000589337

Axiom
annotated source: Biliary Tract
annotated property: has exact synonym
annotated target: biliary tract
term-group: PT
term-source: NCI-GLOSS
source-code: CDR0000559456

Intestine
type: Class
definition: The portion of the gastrointestinal tract between the stomach and the anus. It includes the small intestine and large intestine.
Concept_In_Subset: NCIT C61410
Concept_In_Subset: NCIT C66830
Concept_In_Subset: NCIT C74456
Concept_In_Subset: NCIT C77526
Concept_In_Subset: NCIT C77529
code: C12736
Semantic_Type: Body Part, Organ, or Organ Component
Display_Name: Intestine
Preferred_Name: Intestine
UMLS_CUI: C0021853
Contributing_Source: CDISC
ALT_DEFINITION: The long, tube-shaped organ in the abdomen that completes the process of digestion. The intestine has two parts, the small intestine and the large intestine.
ALT_DEFINITION: The portion of the gastrointestinal tract that includes the small and large intestines.
Legacy_Concept_Name: Intestine
has exact synonym: Bowel
has exact synonym: INTESTINE
has exact synonym: Intestine
has exact synonym: Intestines
has exact synonym: bowel
has exact synonym: intestine
in subset: oncotree slim

Axiom
annotated source: Intestine
annotated property: definition
annotated target: The portion of the gastrointestinal tract between the stomach and the anus. It includes the small intestine and large intestine.
def-source: NCI

Axiom
annotated source: Intestine
annotated property: ALT_DEFINITION
annotated target: The long, tube-shaped organ in the abdomen that completes the process of digestion. The intestine has two parts, the small intestine and the large intestine.
def-source: NCI-GLOSS

Axiom
annotated source: Intestine
annotated property: ALT_DEFINITION
annotated target: The portion of the gastrointestinal tract that includes the small and large intestines.
def-source: CDISC

Axiom
annotated source: Intestine
annotated property: has exact synonym
annotated target: Bowel
term-group: SY
term-source: NCI

Axiom
annotated source: Intestine
annotated property: has exact synonym
annotated target: INTESTINE
term-group: PT
term-source: CDISC

Axiom
annotated source: Intestine
annotated property: has exact synonym
annotated target: Intestine
term-group: PT
term-source: NCI

Axiom
annotated source: Intestine
annotated property: has exact synonym
annotated target: Intestine
term-group: SY
term-source: NCI
source-code: TCGA
subsource-name: caDSR

Axiom
annotated source: Intestine
annotated property: has exact synonym
annotated target: Intestines
term-group: SY
term-source: NCI

Axiom
annotated source: Intestine
annotated property: has exact synonym
annotated target: bowel
term-group: PT
term-source: NCI-GLOSS
source-code: CDR0000046500

Axiom
annotated source: Intestine
annotated property: has exact synonym
annotated target: intestine
term-group: PT
term-source: NCI-GLOSS
source-code: CDR0000046335

Peritoneum
type: Class
definition: The tissue that lines the wall of the abdominal cavity, intestine, and mesentery. It consists of the parietal peritoneum that covers the inside of the abdominal wall and the visceral peritoneum that covers the surface of the intestine and mesentery.
Concept_In_Subset: NCIT C133239
Concept_In_Subset: NCIT C133250
Concept_In_Subset: NCIT C54452
Concept_In_Subset: NCIT C61410
Concept_In_Subset: NCIT C66830
Concept_In_Subset: NCIT C74456
Concept_In_Subset: NCIT C77526
Concept_In_Subset: NCIT C77529
code: C12770
Semantic_Type: Tissue
Display_Name: Peritoneum
Preferred_Name: Peritoneum
UMLS_CUI: C0031153
Contributing_Source: CDISC
Contributing_Source: FDA
ALT_DEFINITION: The membrane that lines the abdominal and pelvic cavities.
ALT_DEFINITION: The tissue that lines the abdominal wall and covers most of the organs in the abdomen.
Legacy_Concept_Name: Peritoneum
has exact synonym: Human Peritoneal Membrane
has exact synonym: PERITONEUM
has exact synonym: Peritoneum
has exact synonym: peritoneum
in subset: oncotree slim

Axiom
annotated source: Peritoneum
annotated property: definition
annotated target: The tissue that lines the wall of the abdominal cavity, intestine, and mesentery. It consists of the parietal peritoneum that covers the inside of the abdominal wall and the visceral peritoneum that covers the surface of the intestine and mesentery.
def-source: NCI

Axiom
annotated source: Peritoneum
annotated property: ALT_DEFINITION
annotated target: The membrane that lines the abdominal and pelvic cavities.
def-source: CDISC

Axiom
annotated source: Peritoneum
annotated property: ALT_DEFINITION
annotated target: The tissue that lines the abdominal wall and covers most of the organs in the abdomen.
def-source: NCI-GLOSS

Axiom
annotated source: Peritoneum
annotated property: has exact synonym
annotated target: Human Peritoneal Membrane
term-group: PT
term-source: FDA
subsource-name: SPL

Axiom
annotated source: Peritoneum
annotated property: has exact synonym
annotated target: PERITONEUM
term-group: PT
term-source: CDISC

Axiom
annotated source: Peritoneum
annotated property: has exact synonym
annotated target: Peritoneum
term-group: PT
term-source: NCI

Axiom
annotated source: Peritoneum
annotated property: has exact synonym
annotated target: Peritoneum
term-group: SY
term-source: NCI
source-code: TCGA
subsource-name: caDSR

Axiom
annotated source: Peritoneum
annotated property: has exact synonym
annotated target: peritoneum
term-group: PT
term-source: NCI-GLOSS
source-code: CDR0000045829

Breast
type: Class
definition: One of two hemispheric projections of variable size situated in the subcutaneous layer over the pectoralis major muscle on either side of the chest.
Concept_In_Subset: NCIT C61410
Concept_In_Subset: NCIT C66830
Concept_In_Subset: NCIT C74456
Concept_In_Subset: NCIT C77526
code: C12971
Semantic_Type: Body Part, Organ, or Organ Component
Display_Name: Breast
Preferred_Name: Breast
UMLS_CUI: C0006141
Contributing_Source: CDISC
ALT_DEFINITION: Glandular organ located on the chest. The breast is made up of connective tissue, fat, and breast tissue that contains the glands that can make milk.
ALT_DEFINITION: One of two hemispheric projections of variable size situated in the subcutaneous layer over the pectoralis major muscle on either side of the chest. (NCI)
Legacy_Concept_Name: Breast
has exact synonym: BREAST
has exact synonym: Breast
has exact synonym: Breasts
has exact synonym: breast
in subset: oncotree slim

Axiom
annotated source: Breast
annotated property: definition
annotated target: One of two hemispheric projections of variable size situated in the subcutaneous layer over the pectoralis major muscle on either side of the chest.
def-source: NCI

Axiom
annotated source: Breast
annotated property: ALT_DEFINITION
annotated target: Glandular organ located on the chest. The breast is made up of connective tissue, fat, and breast tissue that contains the glands that can make milk.
def-source: NCI-GLOSS

Axiom
annotated source: Breast
annotated property: ALT_DEFINITION
annotated target: One of two hemispheric projections of variable size situated in the subcutaneous layer over the pectoralis major muscle on either side of the chest. (NCI)
def-source: CDISC

Axiom
annotated source: Breast
annotated property: has exact synonym
annotated target: BREAST
term-group: PT
term-source: CDISC

Axiom
annotated source: Breast
annotated property: has exact synonym
annotated target: Breast
term-group: PT
term-source: NCI

Axiom
annotated source: Breast
annotated property: has exact synonym
annotated target: Breast
term-group: SY
term-source: CDISC

Axiom
annotated source: Breast
annotated property: has exact synonym
annotated target: Breast
term-group: SY
term-source: NCI
source-code: TCGA
subsource-name: caDSR

Axiom
annotated source: Breast
annotated property: has exact synonym
annotated target: Breasts
term-group: SY
term-source: NCI

Axiom
annotated source: Breast
annotated property: has exact synonym
annotated target: breast
term-group: PT
term-source: NCI-GLOSS
source-code: CDR0000304766

Ampulla of Vater
type: Class
definition: The junction of the common bile and main pancreatic ducts, which protrudes into the medial aspect of the descending duodenum at the major duodenal papilla. The flow of bile and pancreatic juices into the duodenum through the Ampulla of Vater is controlled by the sphincter of Oddi.
code: C13011
Semantic_Type: Body Part, Organ, or Organ Component
Display_Name: Vater's Ampulla
Preferred_Name: Ampulla of Vater
UMLS_CUI: C0042425
ALT_DEFINITION: An enlargement of the ducts from the liver and pancreas at the point where they enter the small intestine.
Legacy_Concept_Name: Ampulla_of_Vater
has exact synonym: Ampulla of Vater
has exact synonym: Vater's Ampulla
has exact synonym: ampulla of Vater
in subset: oncotree slim

Axiom
annotated source: Ampulla of Vater
annotated property: definition
annotated target: The junction of the common bile and main pancreatic ducts, which protrudes into the medial aspect of the descending duodenum at the major duodenal papilla. The flow of bile and pancreatic juices into the duodenum through the Ampulla of Vater is controlled by the sphincter of Oddi.
def-source: NCI

Axiom
annotated source: Ampulla of Vater
annotated property: ALT_DEFINITION
annotated target: An enlargement of the ducts from the liver and pancreas at the point where they enter the small intestine.
def-source: NCI-GLOSS

Axiom
annotated source: Ampulla of Vater
annotated property: has exact synonym
annotated target: Ampulla of Vater
term-group: PT
term-source: NCI

Axiom
annotated source: Ampulla of Vater
annotated property: has exact synonym
annotated target: Ampulla of Vater
term-group: SY
term-source: NCI
source-code: TCGA
subsource-name: caDSR

Axiom
annotated source: Ampulla of Vater
annotated property: has exact synonym
annotated target: Vater's Ampulla
term-group: SY
term-source: NCI

Axiom
annotated source: Ampulla of Vater
annotated property: has exact synonym
annotated target: ampulla of Vater
term-group: PT
term-source: NCI-GLOSS
source-code: CDR0000044316

Lymph
type: Class
definition: A clear, transparent, sometimes faintly yellow and slightly opalescent fluid that is collected from the tissues throughout the body, flows in the lymphatic vessels (through the lymph nodes), and is eventually added to the venous blood circulation. Lymph consists of a clear liquid portion, varying numbers of white blood cells (chiefly lymphocytes), and a few red blood cells.
Concept_In_Subset: NCIT C61410
Concept_In_Subset: NCIT C66830
Concept_In_Subset: NCIT C78734
code: C13252
Semantic_Type: Body Substance
Preferred_Name: Lymph
UMLS_CUI: C0024202
Contributing_Source: CDISC
ALT_DEFINITION: A clear, transparent, sometimes faintly yellow and slightly opalescent fluid that is collected from the tissues throughout the body, flows in the lymphatic vessels (through the lymph nodes), and is eventually added to the venous blood circulation. Lymph consists of a clear liquid portion, varying numbers of white blood cells (chiefly lymphocytes), and a few red blood cells. (NCI)
ALT_DEFINITION: The clear fluid that travels through the lymphatic system and carries cells that help fight infections and other diseases.
Legacy_Concept_Name: Lymph
has exact synonym: LYMPH
has exact synonym: Lymph
has exact synonym: Reticuloendothelial System, Lymph
has exact synonym: lymph
has exact synonym: lymphatic fluid
in subset: oncotree slim

Axiom
annotated source: Lymph
annotated property: definition
annotated target: A clear, transparent, sometimes faintly yellow and slightly opalescent fluid that is collected from the tissues throughout the body, flows in the lymphatic vessels (through the lymph nodes), and is eventually added to the venous blood circulation. Lymph consists of a clear liquid portion, varying numbers of white blood cells (chiefly lymphocytes), and a few red blood cells.
def-source: NCI

Axiom
annotated source: Lymph
annotated property: ALT_DEFINITION
annotated target: A clear, transparent, sometimes faintly yellow and slightly opalescent fluid that is collected from the tissues throughout the body, flows in the lymphatic vessels (through the lymph nodes), and is eventually added to the venous blood circulation. Lymph consists of a clear liquid portion, varying numbers of white blood cells (chiefly lymphocytes), and a few red blood cells. (NCI)
def-source: CDISC

Axiom
annotated source: Lymph
annotated property: ALT_DEFINITION
annotated target: The clear fluid that travels through the lymphatic system and carries cells that help fight infections and other diseases.
def-source: NCI-GLOSS

Axiom
annotated source: Lymph
annotated property: has exact synonym
annotated target: LYMPH
term-group: PT
term-source: CDISC

Axiom
annotated source: Lymph
annotated property: has exact synonym
annotated target: Lymph
term-group: PT
term-source: NCI

Axiom
annotated source: Lymph
annotated property: has exact synonym
annotated target: Reticuloendothelial System, Lymph
term-group: SY
term-source: NCI

Axiom
annotated source: Lymph
annotated property: has exact synonym
annotated target: lymph
term-group: PT
term-source: NCI-GLOSS
source-code: CDR0000046305

Axiom
annotated source: Lymph
annotated property: has exact synonym
annotated target: lymphatic fluid
term-group: PT
term-source: NCI-GLOSS
source-code: CDR0000044434

Other
type: Class
definition: Different than the one(s) previously specified or mentioned.
Has_NICHD_Parent: NCIT C25180
Concept_In_Subset: NCIT C101852
Concept_In_Subset: NCIT C101855
Concept_In_Subset: NCIT C101865
Concept_In_Subset: NCIT C19752
Concept_In_Subset: NCIT C54447
Concept_In_Subset: NCIT C54583
Concept_In_Subset: NCIT C54584
Concept_In_Subset: NCIT C54585
Concept_In_Subset: NCIT C54587
Concept_In_Subset: NCIT C54590
Concept_In_Subset: NCIT C54591
Concept_In_Subset: NCIT C54593
Concept_In_Subset: NCIT C54594
Concept_In_Subset: NCIT C54596
Concept_In_Subset: NCIT C61410
Concept_In_Subset: NCIT C66727
Concept_In_Subset: NCIT C66830
Concept_In_Subset: NCIT C77526
Concept_In_Subset: NCIT C77964
Concept_In_Subset: NCIT C88088
Concept_In_Subset: NCIT C89506
Concept_In_Subset: NCIT C90259
Concept_In_Subset: NCIT C97181
Concept_In_Subset: NCIT C97187
Concept_In_Subset: NCIT C99078
code: C17649
Semantic_Type: Qualitative Concept
Preferred_Name: Other
UMLS_CUI: C0205394
FDA_Table: Device Problem Code (Appendix B)
FDA_Table: Patient Code (Appendix B)
Contributing_Source: CDISC
Contributing_Source: FDA
Contributing_Source: NICHD
ALT_DEFINITION: Different than the one(s) previously specified or mentioned. (NCI)
ALT_DEFINITION: Other (COT/POT/OM)
Legacy_Concept_Name: Other
NICHD_Hierarchy_Term: Other
has exact synonym: OTHER
has exact synonym: Other
has exact synonym: Other or Miscellaneous
in subset: oncotree slim

Axiom
annotated source: Other
annotated property: definition
annotated target: Different than the one(s) previously specified or mentioned.
def-source: NCI

Axiom
annotated source: Other
annotated property: ALT_DEFINITION
annotated target: Different than the one(s) previously specified or mentioned. (NCI)
def-source: CDISC

Axiom
annotated source: Other
annotated property: ALT_DEFINITION
annotated target: Different than the one(s) previously specified or mentioned. (NCI)
def-source: NICHD

Axiom
annotated source: Other
annotated property: ALT_DEFINITION
annotated target: Other (COT/POT/OM)
def-source: FDA
attr: eCTD

Axiom
annotated source: Other
annotated property: has exact synonym
annotated target: OTHER
term-group: PT
term-source: CDISC
source-code: SDTM-ACSPCAT

Axiom
annotated source: Other
annotated property: has exact synonym
annotated target: OTHER
term-group: PT
term-source: CDISC
source-code: SDTM-INTTYPE

Axiom
annotated source: Other
annotated property: has exact synonym
annotated target: OTHER
term-group: PT
term-source: CDISC
source-code: SDTM-NCOMPLT

Axiom
annotated source: Other
annotated property: has exact synonym
annotated target: OTHER
term-group: PT
term-source: CDISC
source-code: SDTM-NSYSPCID

Axiom
annotated source: Other
annotated property: has exact synonym
annotated target: OTHER
term-group: PT
term-source: CDISC
source-code: SDTM-SDTHSDTP

Axiom
annotated source: Other
annotated property: has exact synonym
annotated target: OTHER
term-group: PT
term-source: FDA
subsource-name: ICSR

Axiom
annotated source: Other
annotated property: has exact synonym
annotated target: Other
term-group: PT
term-source: FDA
subsource-name: ICSR-CVM

Axiom
annotated source: Other
annotated property: has exact synonym
annotated target: Other
term-group: PT
term-source: FDA
subsource-name: eCTD

Axiom
annotated source: Other
annotated property: has exact synonym
annotated target: Other
term-group: PT
term-source: NCI

Axiom
annotated source: Other
annotated property: has exact synonym
annotated target: Other
term-group: PT
term-source: NICHD

Axiom
annotated source: Other
annotated property: has exact synonym
annotated target: Other
term-group: SY
term-source: CDISC

Axiom
annotated source: Other
annotated property: has exact synonym
annotated target: Other
term-group: SY
term-source: FDA
subsource-name: ICSR

Axiom
annotated source: Other
annotated property: has exact synonym
annotated target: Other
term-group: SY
term-source: NCI
source-code: CES-D
subsource-name: caDSR

Axiom
annotated source: Other
annotated property: has exact synonym
annotated target: Other
term-group: SY
term-source: NCI
source-code: NHIS
subsource-name: caDSR

Axiom
annotated source: Other
annotated property: has exact synonym
annotated target: Other
term-group: SY
term-source: NCI
source-code: TCGA
subsource-name: caDSR

Axiom
annotated source: Other
annotated property: has exact synonym
annotated target: Other
term-group: SY
term-source: NCI
subsource-name: caDSR

Axiom
annotated source: Other
annotated property: has exact synonym
annotated target: Other or Miscellaneous
term-group: SY
term-source: NCI

Mucinous Adenocarcinoma
type: Class
definition: An invasive adenocarcinoma composed of malignant glandular cells which contain intracytoplasmic mucin. Often, the infiltrating glandular structures are associated with mucoid stromal formation. It may arise from the large and small intestine, appendix, stomach, lung, ovary, breast, corpus uteri, cervix, vagina, and salivary gland.
Concept_In_Subset: NCIT C126659
Concept_In_Subset: NCIT C61410
Concept_In_Subset: NCIT C77526
Concept_In_Subset: NCIT C88025
code: C26712
Semantic_Type: Neoplastic Process
Preferred_Name: Mucinous Adenocarcinoma
UMLS_CUI: C0007130
Contributing_Source: CDISC
ALT_DEFINITION: A type of cancer that begins in cells that line certain internal organs and produce mucin (the main component of mucus).
ALT_DEFINITION: An adenocarcinoma comprising neoplastic glandular cells containing intracytoplasmic mucin.
ICD-O-3_Code: 8480/3
Neoplastic_Status: Malignant
Legacy_Concept_Name: Mucinous_Adenocarcinoma
has exact synonym: ADENOCARCINOMA, MUCINOUS, MALIGNANT
has exact synonym: Colloid Adenocarcinoma
has exact synonym: Colloid Carcinoma
has exact synonym: Gelatinous Adenocarcinoma
has exact synonym: Gelatinous Carcinoma
has exact synonym: Mucinous Adenocarcinoma
has exact synonym: Mucinous Carcinoma
has exact synonym: Mucoid Adenocarcinoma
has exact synonym: Mucoid Carcinoma
has exact synonym: Mucous Adenocarcinoma
has exact synonym: Mucous Carcinoma
has exact synonym: mucinous carcinoma
in subset: oncotree slim

Axiom
annotated source: Mucinous Adenocarcinoma
annotated property: definition
annotated target: An invasive adenocarcinoma composed of malignant glandular cells which contain intracytoplasmic mucin. Often, the infiltrating glandular structures are associated with mucoid stromal formation. It may arise from the large and small intestine, appendix, stomach, lung, ovary, breast, corpus uteri, cervix, vagina, and salivary gland.
def-source: NCI

Axiom
annotated source: Mucinous Adenocarcinoma
annotated property: ALT_DEFINITION
annotated target: A type of cancer that begins in cells that line certain internal organs and produce mucin (the main component of mucus).
def-source: NCI-GLOSS

Axiom
annotated source: Mucinous Adenocarcinoma
annotated property: ALT_DEFINITION
annotated target: An adenocarcinoma comprising neoplastic glandular cells containing intracytoplasmic mucin.
def-source: CDISC

Axiom
annotated source: Mucinous Adenocarcinoma
annotated property: has exact synonym
annotated target: ADENOCARCINOMA, MUCINOUS, MALIGNANT
term-group: PT
term-source: CDISC

Axiom
annotated source: Mucinous Adenocarcinoma
annotated property: has exact synonym
annotated target: Colloid Adenocarcinoma
term-group: SY
term-source: CDISC

Axiom
annotated source: Mucinous Adenocarcinoma
annotated property: has exact synonym
annotated target: Colloid Adenocarcinoma
term-group: SY
term-source: NCI

Axiom
annotated source: Mucinous Adenocarcinoma
annotated property: has exact synonym
annotated target: Colloid Carcinoma
term-group: SY
term-source: CDISC

Axiom
annotated source: Mucinous Adenocarcinoma
annotated property: has exact synonym
annotated target: Colloid Carcinoma
term-group: SY
term-source: NCI

Axiom
annotated source: Mucinous Adenocarcinoma
annotated property: has exact synonym
annotated target: Gelatinous Adenocarcinoma
term-group: SY
term-source: CDISC

Axiom
annotated source: Mucinous Adenocarcinoma
annotated property: has exact synonym
annotated target: Gelatinous Adenocarcinoma
term-group: SY
term-source: NCI

Axiom
annotated source: Mucinous Adenocarcinoma
annotated property: has exact synonym
annotated target: Gelatinous Carcinoma
term-group: SY
term-source: CDISC

Axiom
annotated source: Mucinous Adenocarcinoma
annotated property: has exact synonym
annotated target: Gelatinous Carcinoma
term-group: SY
term-source: NCI

Axiom
annotated source: Mucinous Adenocarcinoma
annotated property: has exact synonym
annotated target: Mucinous Adenocarcinoma
term-group: PT
term-source: NCI

Axiom
annotated source: Mucinous Adenocarcinoma
annotated property: has exact synonym
annotated target: Mucinous Adenocarcinoma
term-group: SY
term-source: NCI
source-code: TCGA
subsource-name: caDSR

Axiom
annotated source: Mucinous Adenocarcinoma
annotated property: has exact synonym
annotated target: Mucinous Carcinoma
term-group: SY
term-source: CDISC

Axiom
annotated source: Mucinous Adenocarcinoma
annotated property: has exact synonym
annotated target: Mucinous Carcinoma
term-group: SY
term-source: NCI

Axiom
annotated source: Mucinous Adenocarcinoma
annotated property: has exact synonym
annotated target: Mucoid Adenocarcinoma
term-group: SY
term-source: CDISC

Axiom
annotated source: Mucinous Adenocarcinoma
annotated property: has exact synonym
annotated target: Mucoid Adenocarcinoma
term-group: SY
term-source: NCI

Axiom
annotated source: Mucinous Adenocarcinoma
annotated property: has exact synonym
annotated target: Mucoid Carcinoma
term-group: SY
term-source: CDISC

Axiom
annotated source: Mucinous Adenocarcinoma
annotated property: has exact synonym
annotated target: Mucoid Carcinoma
term-group: SY
term-source: NCI

Axiom
annotated source: Mucinous Adenocarcinoma
annotated property: has exact synonym
annotated target: Mucous Adenocarcinoma
term-group: SY
term-source: CDISC

Axiom
annotated source: Mucinous Adenocarcinoma
annotated property: has exact synonym
annotated target: Mucous Adenocarcinoma
term-group: SY
term-source: NCI

Axiom
annotated source: Mucinous Adenocarcinoma
annotated property: has exact synonym
annotated target: Mucous Carcinoma
term-group: SY
term-source: CDISC

Axiom
annotated source: Mucinous Adenocarcinoma
annotated property: has exact synonym
annotated target: Mucous Carcinoma
term-group: SY
term-source: NCI

Axiom
annotated source: Mucinous Adenocarcinoma
annotated property: has exact synonym
annotated target: mucinous carcinoma
term-group: PT
term-source: NCI-GLOSS
source-code: CDR0000044289

Proliferating Pilar Tumor
type: Class
definition: A neoplasm with tricholemmal differentiation. It affects women more frequently than men. It usually presents on the scalp as a solitary, multilobular, large, exophytic mass. Morphologically, it may display benign cytological features and appear as a circumscribed solid-cystic neoplasm or it may display malignant characteristics and invasive features. Cases without malignant characteristics usually have an indolent course. Complete surgical excision is recommended in such cases to avoid recurrences and to allow complete examination of the specimen. Cases with malignant characteristics may have a locally aggressive clinical course, recur, or metastasize.
code: C27125
Semantic_Type: Neoplastic Process
Preferred_Name: Proliferating Pilar Tumor
UMLS_CUI: C0086809
ICD-O-3_Code: 8103/0
ICD-O-3_Code: 8103/1
Neoplastic_Status: Undetermined
Legacy_Concept_Name: Pilar_Tumor
has exact synonym: Pilar Cyst
has exact synonym: Pilar Tumor
has exact synonym: Proliferating Pilar Tumor
has exact synonym: Proliferating Trichilemmal Cyst
has exact synonym: Proliferating Trichilemmal Tumor
has exact synonym: Proliferating Tricholemmal Tumor
in subset: oncotree slim

Axiom
annotated source: Proliferating Pilar Tumor
annotated property: definition
annotated target: A neoplasm with tricholemmal differentiation. It affects women more frequently than men. It usually presents on the scalp as a solitary, multilobular, large, exophytic mass. Morphologically, it may display benign cytological features and appear as a circumscribed solid-cystic neoplasm or it may display malignant characteristics and invasive features. Cases without malignant characteristics usually have an indolent course. Complete surgical excision is recommended in such cases to avoid recurrences and to allow complete examination of the specimen. Cases with malignant characteristics may have a locally aggressive clinical course, recur, or metastasize.
def-source: NCI

Axiom
annotated source: Proliferating Pilar Tumor
annotated property: has exact synonym
annotated target: Pilar Cyst
term-group: SY
term-source: NCI

Axiom
annotated source: Proliferating Pilar Tumor
annotated property: has exact synonym
annotated target: Pilar Tumor
term-group: SY
term-source: NCI

Axiom
annotated source: Proliferating Pilar Tumor
annotated property: has exact synonym
annotated target: Proliferating Pilar Tumor
term-group: PT
term-source: NCI

Axiom
annotated source: Proliferating Pilar Tumor
annotated property: has exact synonym
annotated target: Proliferating Trichilemmal Cyst
term-group: SY
term-source: NCI

Axiom
annotated source: Proliferating Pilar Tumor
annotated property: has exact synonym
annotated target: Proliferating Trichilemmal Tumor
term-group: SY
term-source: NCI

Axiom
annotated source: Proliferating Pilar Tumor
annotated property: has exact synonym
annotated target: Proliferating Tricholemmal Tumor
term-group: SY
term-source: NCI

Uterine Corpus Choriocarcinoma
type: Class
definition: An aggressive malignant tumor arising from trophoblastic cells in the uterus during pregnancy. Approximately half of the cases develop from a complete hydatidiform mole. There is often marked elevation of human chorionic gonadotropin (hCG) in the blood. Choriocarcinomas disseminate rapidly through the hematogenous route; the lungs are most frequently affected.
Concept_In_Subset: NCIT C116977
code: C27246
Semantic_Type: Neoplastic Process
Display_Name: Uterine Corpus Choriocarcinoma
Preferred_Name: Uterine Corpus Choriocarcinoma
UMLS_CUI: C0279677
Contributing_Source: CTRP
Neoplastic_Status: Malignant
Legacy_Concept_Name: Uterine_Corpus_Choriocarcinoma
has exact synonym: Gestational Uterine Corpus Choriocarcinoma
has exact synonym: Uterine Corpus Choriocarcinoma
has exact synonym: Uterine Corpus Gestational Choriocarcinoma
in subset: oncotree slim

Axiom
annotated source: Uterine Corpus Choriocarcinoma
annotated property: definition
annotated target: An aggressive malignant tumor arising from trophoblastic cells in the uterus during pregnancy. Approximately half of the cases develop from a complete hydatidiform mole. There is often marked elevation of human chorionic gonadotropin (hCG) in the blood. Choriocarcinomas disseminate rapidly through the hematogenous route; the lungs are most frequently affected.
def-source: NCI

Axiom
annotated source: Uterine Corpus Choriocarcinoma
annotated property: has exact synonym
annotated target: Gestational Uterine Corpus Choriocarcinoma
term-group: SY
term-source: NCI

Axiom
annotated source: Uterine Corpus Choriocarcinoma
annotated property: has exact synonym
annotated target: Uterine Corpus Choriocarcinoma
term-group: PT
term-source: NCI

Axiom
annotated source: Uterine Corpus Choriocarcinoma
annotated property: has exact synonym
annotated target: Uterine Corpus Gestational Choriocarcinoma
term-group: SY
term-source: NCI

Poroma
type: Class
definition: A benign, well circumscribed sweat gland neoplasm with eccrine or apocrine differentiation. It usually presents as a solitary, dome-shaped papule, nodule, or plaque on acral sites. It is characterized by a proliferation of uniform basaloid cells in the dermis and it is associated with the presence of focal ductal and cystic structures. Complete excision is curative.
Concept_In_Subset: NCIT C126659
code: C27273
Semantic_Type: Neoplastic Process
Preferred_Name: Poroma
UMLS_CUI: C1533161
ICD-O-3_Code: 8409/0
Neoplastic_Status: Benign
Legacy_Concept_Name: Poroma_Acrospiroma
has exact synonym: Eccrine Poroma
has exact synonym: Poroma
in subset: oncotree slim

Axiom
annotated source: Poroma
annotated property: definition
annotated target: A benign, well circumscribed sweat gland neoplasm with eccrine or apocrine differentiation. It usually presents as a solitary, dome-shaped papule, nodule, or plaque on acral sites. It is characterized by a proliferation of uniform basaloid cells in the dermis and it is associated with the presence of focal ductal and cystic structures. Complete excision is curative.
def-source: NCI

Axiom
annotated source: Poroma
annotated property: has exact synonym
annotated target: Eccrine Poroma
term-group: SY
term-source: NCI

Axiom
annotated source: Poroma
annotated property: has exact synonym
annotated target: Poroma
term-group: PT
term-source: NCI

Histiocytic Sarcoma
type: Class
subclass of: NCIT C9294
definition: An aggressive malignant neoplasm with a poor response to therapy, usually presenting as stage III/IV disease. It is characterized by the presence of neoplastic cells with morphologic and immunophenotypic characteristics similar to those seen in mature histiocytes.
Concept_In_Subset: NCIT C126659
Concept_In_Subset: NCIT C61410
Concept_In_Subset: NCIT C77526
Concept_In_Subset: NCIT C88025
code: C27349
Semantic_Type: Neoplastic Process
Preferred_Name: Histiocytic Sarcoma
UMLS_CUI: C0334663
Contributing_Source: CDISC
ALT_DEFINITION: A malignant neoplasm composed of cells resembling histiocytes.
ICD-O-3_Code: 9755/3
Neoplastic_Status: Malignant
Legacy_Concept_Name: Histiocytic_Sarcoma
has exact synonym: Histiocytic Sarcoma
has exact synonym: SARCOMA, HISTIOCYTIC, MALIGNANT
in subset: oncotree slim

Axiom
annotated source: Histiocytic Sarcoma
annotated property: definition
annotated target: An aggressive malignant neoplasm with a poor response to therapy, usually presenting as stage III/IV disease. It is characterized by the presence of neoplastic cells with morphologic and immunophenotypic characteristics similar to those seen in mature histiocytes.
def-source: NCI

Axiom
annotated source: Histiocytic Sarcoma
annotated property: ALT_DEFINITION
annotated target: A malignant neoplasm composed of cells resembling histiocytes.
def-source: CDISC

Axiom
annotated source: Histiocytic Sarcoma
annotated property: has exact synonym
annotated target: Histiocytic Sarcoma
term-group: PT
term-source: NCI

Axiom
annotated source: Histiocytic Sarcoma
annotated property: has exact synonym
annotated target: Histiocytic Sarcoma
term-group: SY
term-source: NCI
source-code: TCGA
subsource-name: caDSR

Axiom
annotated source: Histiocytic Sarcoma
annotated property: has exact synonym
annotated target: SARCOMA, HISTIOCYTIC, MALIGNANT
term-group: PT
term-source: CDISC

Ovarian Small Cell Carcinoma
type: Class
subclass of: Ovarian Carcinoma
definition: A carcinoma that arises from the ovary and is characterized by the presence of small malignant cells. It includes small cell carcinoma, hypercalcemic type and small cell carcinoma, pulmonary type.
Concept_In_Subset: NCIT C126659
code: C27390
Semantic_Type: Neoplastic Process
Preferred_Name: Ovarian Small Cell Carcinoma
UMLS_CUI: C2212006
Neoplastic_Status: Malignant
Legacy_Concept_Name: Ovarian_Small_Cell_Carcinoma
has exact synonym: Ovarian Small Cell Cancer
has exact synonym: Ovarian Small Cell Carcinoma
has exact synonym: Ovarian Small Cell NEC
has exact synonym: Ovarian Small Cell Neuroendocrine Carcinoma
in subset: oncotree slim

Axiom
annotated source: Ovarian Small Cell Carcinoma
annotated property: definition
annotated target: A carcinoma that arises from the ovary and is characterized by the presence of small malignant cells. It includes small cell carcinoma, hypercalcemic type and small cell carcinoma, pulmonary type.
def-source: NCI

Axiom
annotated source: Ovarian Small Cell Carcinoma
annotated property: has exact synonym
annotated target: Ovarian Small Cell Cancer
term-group: DN
term-source: CTRP

Axiom
annotated source: Ovarian Small Cell Carcinoma
annotated property: has exact synonym
annotated target: Ovarian Small Cell Carcinoma
term-group: PT
term-source: NCI

Axiom
annotated source: Ovarian Small Cell Carcinoma
annotated property: has exact synonym
annotated target: Ovarian Small Cell NEC
term-group: SY
term-source: NCI

Axiom
annotated source: Ovarian Small Cell Carcinoma
annotated property: has exact synonym
annotated target: Ovarian Small Cell Neuroendocrine Carcinoma
term-group: SY
term-source: NCI

Vaginal Melanoma
type: Class
definition: A primary malignant neoplasm of the vagina composed of malignant melanocytes.
code: C27394
Semantic_Type: Neoplastic Process
Preferred_Name: Vaginal Melanoma
UMLS_CUI: C2004576
Neoplastic_Status: Malignant
Legacy_Concept_Name: Vaginal_Melanoma
has exact synonym: Melanoma of Vagina
has exact synonym: Melanoma of the Vagina
has exact synonym: Vaginal Melanoma
in subset: oncotree slim

Axiom
annotated source: Vaginal Melanoma
annotated property: definition
annotated target: A primary malignant neoplasm of the vagina composed of malignant melanocytes.
def-source: NCI

Axiom
annotated source: Vaginal Melanoma
annotated property: has exact synonym
annotated target: Melanoma of Vagina
term-group: SY
term-source: NCI

Axiom
annotated source: Vaginal Melanoma
annotated property: has exact synonym
annotated target: Melanoma of the Vagina
term-group: SY
term-source: NCI

Axiom
annotated source: Vaginal Melanoma
annotated property: has exact synonym
annotated target: Vaginal Melanoma
term-group: PT
term-source: NCI

Extraskeletal Myxoid Chondrosarcoma
type: Class
definition: A rare malignant soft tissue neoplasm of uncertain differentiation, characterized by the presence of chondroblast-like cells in a myxoid stroma and a multinodular growth pattern. The most common sites of involvement are the deep soft tissues of the extremities, particularly the thigh. It usually presents as an enlarging soft tissue mass. Patients may have long survivals, but local recurrences and metastases occur in approximately half of the cases. The most common site of metastasis is the lungs.
code: C27502
Semantic_Type: Neoplastic Process
Preferred_Name: Extraskeletal Myxoid Chondrosarcoma
UMLS_CUI: C1275278
Neoplastic_Status: Malignant
Legacy_Concept_Name: Myxoid_Extraskeletal_Chondrosarcoma
has exact synonym: EMC
has exact synonym: Extraosseous Chondrosarcoma
has exact synonym: Extraskeletal Chondrosarcoma
has exact synonym: Extraskeletal Myxoid Chondrosarcoma
has exact synonym: Myxoid Extraosseous Chondrosarcoma
has exact synonym: Myxoid Extraskeletal Chondrosarcoma
in subset: oncotree slim

Axiom
annotated source: Extraskeletal Myxoid Chondrosarcoma
annotated property: definition
annotated target: A rare malignant soft tissue neoplasm of uncertain differentiation, characterized by the presence of chondroblast-like cells in a myxoid stroma and a multinodular growth pattern. The most common sites of involvement are the deep soft tissues of the extremities, particularly the thigh. It usually presents as an enlarging soft tissue mass. Patients may have long survivals, but local recurrences and metastases occur in approximately half of the cases. The most common site of metastasis is the lungs.
def-source: NCI

Axiom
annotated source: Extraskeletal Myxoid Chondrosarcoma
annotated property: has exact synonym
annotated target: EMC
term-group: AB
term-source: NCI

Axiom
annotated source: Extraskeletal Myxoid Chondrosarcoma
annotated property: has exact synonym
annotated target: Extraosseous Chondrosarcoma
term-group: SY
term-source: NCI

Axiom
annotated source: Extraskeletal Myxoid Chondrosarcoma
annotated property: has exact synonym
annotated target: Extraskeletal Chondrosarcoma
term-group: SY
term-source: NCI

Axiom
annotated source: Extraskeletal Myxoid Chondrosarcoma
annotated property: has exact synonym
annotated target: Extraskeletal Myxoid Chondrosarcoma
term-group: PT
term-source: NCI

Axiom
annotated source: Extraskeletal Myxoid Chondrosarcoma
annotated property: has exact synonym
annotated target: Myxoid Extraosseous Chondrosarcoma
term-group: SY
term-source: NCI

Axiom
annotated source: Extraskeletal Myxoid Chondrosarcoma
annotated property: has exact synonym
annotated target: Myxoid Extraskeletal Chondrosarcoma
term-group: SY
term-source: NCI

Desmoplastic Trichoepithelioma
type: Class
code: C27524
Semantic_Type: Neoplastic Process
Preferred_Name: Desmoplastic Trichoepithelioma
UMLS_CUI: C0432526
Neoplastic_Status: Benign
Legacy_Concept_Name: Desmoplastic_Trichoepithelioma
has exact synonym: Desmoplastic Trichoepithelioma
has exact synonym: Sclerosing Epithelial Hamartoma
in subset: oncotree slim

Axiom
annotated source: Desmoplastic Trichoepithelioma
annotated property: has exact synonym
annotated target: Desmoplastic Trichoepithelioma
term-group: PT
term-source: NCI

Axiom
annotated source: Desmoplastic Trichoepithelioma
annotated property: has exact synonym
annotated target: Sclerosing Epithelial Hamartoma
term-group: SY
term-source: NCI

Digital Papillary Eccrine Carcinoma
type: Class
definition: An adenocarcinoma arising from the sweat glands. Most cases present as nodular lesions on the digits, usually in the hands. It is characterized by the presence of epithelial cells in the dermis forming nodules. Cystic structures containing papillary projections are also present. It may recur and metastasize, most commonly to the lungs.
code: C27534
Semantic_Type: Neoplastic Process
Preferred_Name: Digital Papillary Eccrine Carcinoma
UMLS_CUI: C1367789
ICD-O-3_Code: 8408/1
ICD-O-3_Code: 8408/3
Neoplastic_Status: Malignant
Legacy_Concept_Name: Aggressive_Digital_Papillary_Adenocarcinoma
has exact synonym: Digital Papillary Carcinoma
has exact synonym: Digital Papillary Eccrine Carcinoma
has exact synonym: Papillary Digital Eccrine Carcinoma
in subset: oncotree slim

Axiom
annotated source: Digital Papillary Eccrine Carcinoma
annotated property: definition
annotated target: An adenocarcinoma arising from the sweat glands. Most cases present as nodular lesions on the digits, usually in the hands. It is characterized by the presence of epithelial cells in the dermis forming nodules. Cystic structures containing papillary projections are also present. It may recur and metastasize, most commonly to the lungs.
def-source: NCI

Axiom
annotated source: Digital Papillary Eccrine Carcinoma
annotated property: has exact synonym
annotated target: Digital Papillary Carcinoma
term-group: SY
term-source: NCI

Axiom
annotated source: Digital Papillary Eccrine Carcinoma
annotated property: has exact synonym
annotated target: Digital Papillary Eccrine Carcinoma
term-group: PT
term-source: NCI

Axiom
annotated source: Digital Papillary Eccrine Carcinoma
annotated property: has exact synonym
annotated target: Papillary Digital Eccrine Carcinoma
term-group: SY
term-source: NCI

Pancreatic Neuroendocrine Tumor
type: Class
subclass of: NCIT C95404
definition: A low or intermediate grade well differentiated tumor with neuroendocrine differentiation that arises from the pancreas. According to the presence or absence of clinical syndromes that result from hormone hypersecretion, pancreatic neuroendocrine tumors are classified either as functional or nonfunctional.
Concept_In_Subset: NCIT C102905
Concept_In_Subset: NCIT C103057
Concept_In_Subset: NCIT C116977
Concept_In_Subset: NCIT C126659
code: C27720
Semantic_Type: Neoplastic Process
Display_Name: Pancreatic Neuroendocrine Tumor
Preferred_Name: Pancreatic Neuroendocrine Tumor
UMLS_CUI: C1337011
Contributing_Source: CTEP
Contributing_Source: CTRP
ALT_DEFINITION: A mass of abnormal cells that forms in the endocrine (hormone-producing) tissues of the pancreas. Islet cell tumors may be benign (not cancer) or malignant (cancer).
ICD-O-3_Code: 8150/1
Neoplastic_Status: Undetermined
Legacy_Concept_Name: Well-Differentiated_Pancreatic_Endocrine_Neoplasm
has exact synonym: Islet Cell Tumor
has exact synonym: Islet cell tumors - pancreas
has exact synonym: Islet cell tumors of the pancreas
has exact synonym: Pancreatic NET
has exact synonym: Pancreatic Neuroendocrine Tumor
has exact synonym: Well Differentiated Pancreatic Endocrine Neoplasm
has exact synonym: Well Differentiated Pancreatic Endocrine Tumor
has exact synonym: islet cell tumor
in subset: oncotree slim

Axiom
annotated source: Pancreatic Neuroendocrine Tumor
annotated property: definition
annotated target: A low or intermediate grade well differentiated tumor with neuroendocrine differentiation that arises from the pancreas. According to the presence or absence of clinical syndromes that result from hormone hypersecretion, pancreatic neuroendocrine tumors are classified either as functional or nonfunctional.
def-source: NCI

Axiom
annotated source: Pancreatic Neuroendocrine Tumor
annotated property: ALT_DEFINITION
annotated target: A mass of abnormal cells that forms in the endocrine (hormone-producing) tissues of the pancreas. Islet cell tumors may be benign (not cancer) or malignant (cancer).
def-source: NCI-GLOSS

Axiom
annotated source: Pancreatic Neuroendocrine Tumor
annotated property: has exact synonym
annotated target: Islet Cell Tumor
term-group: SY
term-source: NCI

Axiom
annotated source: Pancreatic Neuroendocrine Tumor
annotated property: has exact synonym
annotated target: Islet cell tumors - pancreas
term-group: SY
term-source: CTEP
source-code: 10033630
subsource-name: SDC

Axiom
annotated source: Pancreatic Neuroendocrine Tumor
annotated property: has exact synonym
annotated target: Islet cell tumors of the pancreas
term-group: PT
term-source: CTEP
source-code: 10033630
subsource-name: SDC

Axiom
annotated source: Pancreatic Neuroendocrine Tumor
annotated property: has exact synonym
annotated target: Pancreatic NET
term-group: SY
term-source: NCI

Axiom
annotated source: Pancreatic Neuroendocrine Tumor
annotated property: has exact synonym
annotated target: Pancreatic Neuroendocrine Tumor
term-group: PT
term-source: NCI

Axiom
annotated source: Pancreatic Neuroendocrine Tumor
annotated property: has exact synonym
annotated target: Well Differentiated Pancreatic Endocrine Neoplasm
term-group: SY
term-source: NCI

Axiom
annotated source: Pancreatic Neuroendocrine Tumor
annotated property: has exact synonym
annotated target: Well Differentiated Pancreatic Endocrine Tumor
term-group: SY
term-source: NCI

Axiom
annotated source: Pancreatic Neuroendocrine Tumor
annotated property: has exact synonym
annotated target: islet cell tumor
term-group: PT
term-source: NCI-GLOSS
source-code: CDR0000573196

Porphyria Cutanea Tarda
type: Class
definition: A cutaneous form of the genetic photosensitive disease, porphyria, that is characterized by onset in adult life and the presence of scarring bullae, hyperpigmentation, facial hypertrichosis, and sometimes sclerodermatous thickenings and alopecia. Uroporphyrins are found in the urine due to a deficiency of uroporphyrinogen decarboxylase, an enzyme required for the synthesis of heme.
code: C27725
Semantic_Type: Disease or Syndrome
Preferred_Name: Porphyria Cutanea Tarda
UMLS_CUI: C0162566
Legacy_Concept_Name: Porphyria_Cutanea_Tarda
has exact synonym: Porphyria Cutanea Tarda
in subset: oncotree slim

Axiom
annotated source: Porphyria Cutanea Tarda
annotated property: definition
annotated target: A cutaneous form of the genetic photosensitive disease, porphyria, that is characterized by onset in adult life and the presence of scarring bullae, hyperpigmentation, facial hypertrichosis, and sometimes sclerodermatous thickenings and alopecia. Uroporphyrins are found in the urine due to a deficiency of uroporphyrinogen decarboxylase, an enzyme required for the synthesis of heme.
def-source: NCI

Axiom
annotated source: Porphyria Cutanea Tarda
annotated property: has exact synonym
annotated target: Porphyria Cutanea Tarda
term-group: PT
term-source: NCI

Myxoid Liposarcoma
type: Class
subclass of: Liposarcoma
definition: A liposarcoma characterized by the presence of round non-lipogenic primitive mesenchymal cells and small signet ring lipoblasts within a myxoid stoma with a branching vascular pattern. This category includes hypercellular lesions with round cell morphology, formerly known as round cell liposarcoma.
Concept_In_Subset: NCIT C126659
code: C27781
Semantic_Type: Neoplastic Process
Preferred_Name: Myxoid Liposarcoma
UMLS_CUI: C0206634
ICD-O-3_Code: 8852/3
Neoplastic_Status: Malignant
Legacy_Concept_Name: Myxoid_Round_Cell_Liposarcoma
has exact synonym: Myxoid Liposarcoma
has exact synonym: Myxoid/Round Cell Liposarcoma
in subset: oncotree slim

Axiom
annotated source: Myxoid Liposarcoma
annotated property: definition
annotated target: A liposarcoma characterized by the presence of round non-lipogenic primitive mesenchymal cells and small signet ring lipoblasts within a myxoid stoma with a branching vascular pattern. This category includes hypercellular lesions with round cell morphology, formerly known as round cell liposarcoma.
def-source: NCI

Axiom
annotated source: Myxoid Liposarcoma
annotated property: has exact synonym
annotated target: Myxoid Liposarcoma
term-group: PT
term-source: NCI

Axiom
annotated source: Myxoid Liposarcoma
annotated property: has exact synonym
annotated target: Myxoid Liposarcoma
term-group: SY
term-source: NCI

Axiom
annotated source: Myxoid Liposarcoma
annotated property: has exact synonym
annotated target: Myxoid/Round Cell Liposarcoma
term-group: SY
term-source: NCI

Endometrial Serous Adenocarcinoma
type: Class
definition: A high grade, aggressive adenocarcinoma arising from the endometrium. It is characterized by the presence of complex papillary patterns with cellular budding. Atypical mitoses, necrosis, and psammoma bodies may be present. It is classified as type II endometrial carcinoma and it is not associated with endometrial hyperplasia. It tends to invade deeply into the myometrium and spreads into the lymphatic vessels. Patients frequently present with spread of the tumor beyond the uterus at the time of diagnosis. The prognosis is usually poor.
Concept_In_Subset: NCIT C102905
Concept_In_Subset: NCIT C103103
Concept_In_Subset: NCIT C116977
Concept_In_Subset: NCIT C126659
code: C27838
Semantic_Type: Neoplastic Process
Display_Name: Endometrial Serous Adenocarcinoma
Preferred_Name: Endometrial Serous Adenocarcinoma
UMLS_CUI: C0854924
Contributing_Source: CTEP
Contributing_Source: CTRP
Neoplastic_Status: Malignant
Legacy_Concept_Name: Uterine_Serous_Carcinoma
has exact synonym: Endometrial Serous Adenocarcinoma
has exact synonym: Serous endometrial adenocarcinoma
has exact synonym: Uterine Corpus Serous Adenocarcinoma
has exact synonym: Uterine Papillary Serous Carcinoma
has exact synonym: Uterine Serous Adenocarcinoma
has exact synonym: Uterine Serous Carcinoma
has exact synonym: Uterine Serous Papillary Adenocarcinoma
in subset: oncotree slim

Axiom
annotated source: Endometrial Serous Adenocarcinoma
annotated property: definition
annotated target: A high grade, aggressive adenocarcinoma arising from the endometrium. It is characterized by the presence of complex papillary patterns with cellular budding. Atypical mitoses, necrosis, and psammoma bodies may be present. It is classified as type II endometrial carcinoma and it is not associated with endometrial hyperplasia. It tends to invade deeply into the myometrium and spreads into the lymphatic vessels. Patients frequently present with spread of the tumor beyond the uterus at the time of diagnosis. The prognosis is usually poor.
def-source: NCI

Axiom
annotated source: Endometrial Serous Adenocarcinoma
annotated property: has exact synonym
annotated target: Endometrial Serous Adenocarcinoma
term-group: PT
term-source: NCI

Axiom
annotated source: Endometrial Serous Adenocarcinoma
annotated property: has exact synonym
annotated target: Endometrial Serous Adenocarcinoma
term-group: SY
term-source: NCI
source-code: TCGA
subsource-name: caDSR

Axiom
annotated source: Endometrial Serous Adenocarcinoma
annotated property: has exact synonym
annotated target: Serous endometrial adenocarcinoma
term-group: PT
term-source: CTEP
source-code: 10033700
subsource-name: SDC

Axiom
annotated source: Endometrial Serous Adenocarcinoma
annotated property: has exact synonym
annotated target: Uterine Corpus Serous Adenocarcinoma
term-group: SY
term-source: NCI

Axiom
annotated source: Endometrial Serous Adenocarcinoma
annotated property: has exact synonym
annotated target: Uterine Papillary Serous Carcinoma
term-group: SY
term-source: NCI

Axiom
annotated source: Endometrial Serous Adenocarcinoma
annotated property: has exact synonym
annotated target: Uterine Serous Adenocarcinoma
term-group: SY
term-source: NCI

Axiom
annotated source: Endometrial Serous Adenocarcinoma
annotated property: has exact synonym
annotated target: Uterine Serous Carcinoma
term-group: SY
term-source: NCI

Axiom
annotated source: Endometrial Serous Adenocarcinoma
annotated property: has exact synonym
annotated target: Uterine Serous Papillary Adenocarcinoma
term-group: SY
term-source: NCI

Renal Cell Carcinoma Associated with Xp11.2 Translocations/TFE3 Gene Fusions
type: Class
subclass of: NCIT C9385
definition: A group of kidney carcinomas characterized by the presence of different translocations involving the chromosome Xp11.2. These translocations result in the creation of gene fusions involving the TFE3 gene. Patients are usually children and young adults. Morphologically, the malignant epithelial cells form papillary patterns.
Concept_In_Subset: NCIT C126659
code: C27891
Semantic_Type: Neoplastic Process
Preferred_Name: Renal Cell Carcinoma Associated with Xp11.2 Translocations/TFE3 Gene Fusions
UMLS_CUI: C1337036
ICD-O-3_Code: 0000/0
Neoplastic_Status: Malignant
Legacy_Concept_Name: Xp11_Translocation-Related_Renal_Cell_Carcinoma
has exact synonym: Renal Cell Cancer Associated with Xp11.2 Translocations/TFE3 Gene Fusions
has exact synonym: Renal Cell Carcinoma Associated with Xp11.2 Translocations/TFE3 Gene Fusions
has exact synonym: Xp11.2 Translocation-Related Renal Cell Carcinoma
in subset: oncotree slim

Axiom
annotated source: Renal Cell Carcinoma Associated with Xp11.2 Translocations/TFE3 Gene Fusions
annotated property: definition
annotated target: A group of kidney carcinomas characterized by the presence of different translocations involving the chromosome Xp11.2. These translocations result in the creation of gene fusions involving the TFE3 gene. Patients are usually children and young adults. Morphologically, the malignant epithelial cells form papillary patterns.
def-source: NCI

Axiom
annotated source: Renal Cell Carcinoma Associated with Xp11.2 Translocations/TFE3 Gene Fusions
annotated property: has exact synonym
annotated target: Renal Cell Cancer Associated with Xp11.2 Translocations/TFE3 Gene Fusions
term-group: DN
term-source: CTRP

Axiom
annotated source: Renal Cell Carcinoma Associated with Xp11.2 Translocations/TFE3 Gene Fusions
annotated property: has exact synonym
annotated target: Renal Cell Carcinoma Associated with Xp11.2 Translocations/TFE3 Gene Fusions
term-group: PT
term-source: NCI

Axiom
annotated source: Renal Cell Carcinoma Associated with Xp11.2 Translocations/TFE3 Gene Fusions
annotated property: has exact synonym
annotated target: Xp11.2 Translocation-Related Renal Cell Carcinoma
term-group: SY
term-source: NCI

Unclassified Renal Cell Carcinoma
type: Class
subclass of: NCIT C9385
definition: A renal cell carcinoma characterized by morphologic features that do not fit easily into one of the other well-defined categories of renal cell carcinoma. Examples of such features include mixtures of morphologic patterns, mucin production, and sarcomatoid morphology.
Concept_In_Subset: NCIT C126659
code: C27892
Semantic_Type: Neoplastic Process
Preferred_Name: Unclassified Renal Cell Carcinoma
UMLS_CUI: C1336853
Neoplastic_Status: Malignant
Legacy_Concept_Name: Unclassified_Renal_Cell_Carcinoma
has exact synonym: Unclassified Renal Cell Cancer
has exact synonym: Unclassified Renal Cell Carcinoma
in subset: oncotree slim

Axiom
annotated source: Unclassified Renal Cell Carcinoma
annotated property: definition
annotated target: A renal cell carcinoma characterized by morphologic features that do not fit easily into one of the other well-defined categories of renal cell carcinoma. Examples of such features include mixtures of morphologic patterns, mucin production, and sarcomatoid morphology.
def-source: NCI

Axiom
annotated source: Unclassified Renal Cell Carcinoma
annotated property: has exact synonym
annotated target: Unclassified Renal Cell Cancer
term-group: DN
term-source: CTRP

Axiom
annotated source: Unclassified Renal Cell Carcinoma
annotated property: has exact synonym
annotated target: Unclassified Renal Cell Carcinoma
term-group: PT
term-source: NCI

Axiom
annotated source: Unclassified Renal Cell Carcinoma
annotated property: has exact synonym
annotated target: Unclassified Renal Cell Carcinoma
term-group: SY
term-source: NCI
source-code: TCGA
subsource-name: caDSR

Sarcomatoid Renal Cell Carcinoma
type: Class
subclass of: NCIT C9385
definition: A high grade carcinoma of the kidney. It is not a distinct clinicopathological entity and includes a diverse group of renal cell carcinomas which have been transformed from a lower to a higher grade.
Concept_In_Subset: NCIT C102905
Concept_In_Subset: NCIT C103084
Concept_In_Subset: NCIT C126659
code: C27893
Semantic_Type: Neoplastic Process
Preferred_Name: Sarcomatoid Renal Cell Carcinoma
UMLS_CUI: C1266043
Contributing_Source: CTEP
ICD-O-3_Code: 8318/3
Neoplastic_Status: Malignant
Legacy_Concept_Name: Sarcomatoid_Renal_Cell_Carcinoma
has exact synonym: RCC w/ sarcomatoid features
has exact synonym: Renal cell carcinoma with sarcomatoid features
has exact synonym: Sarcomatoid Renal Cell Cancer
has exact synonym: Sarcomatoid Renal Cell Carcinoma
in subset: oncotree slim

Axiom
annotated source: Sarcomatoid Renal Cell Carcinoma
annotated property: definition
annotated target: A high grade carcinoma of the kidney. It is not a distinct clinicopathological entity and includes a diverse group of renal cell carcinomas which have been transformed from a lower to a higher grade.
def-source: NCI

Axiom
annotated source: Sarcomatoid Renal Cell Carcinoma
annotated property: has exact synonym
annotated target: RCC w/ sarcomatoid features
term-group: SY
term-source: CTEP
source-code: 10066352
subsource-name: SDC

Axiom
annotated source: Sarcomatoid Renal Cell Carcinoma
annotated property: has exact synonym
annotated target: Renal cell carcinoma with sarcomatoid features
term-group: PT
term-source: CTEP
source-code: 10066352
subsource-name: SDC

Axiom
annotated source: Sarcomatoid Renal Cell Carcinoma
annotated property: has exact synonym
annotated target: Sarcomatoid Renal Cell Cancer
term-group: DN
term-source: CTRP

Axiom
annotated source: Sarcomatoid Renal Cell Carcinoma
annotated property: has exact synonym
annotated target: Sarcomatoid Renal Cell Carcinoma
term-group: PT
term-source: NCI

Endocervical Carcinoma
type: Class
definition: An adenocarcinoma characterized by the presence of malignant glandular epithelium resembling the endocervical epithelium.
Concept_In_Subset: NCIT C126659
code: C28327
Semantic_Type: Neoplastic Process
Preferred_Name: Endocervical Carcinoma
UMLS_CUI: C1299237
Neoplastic_Status: Malignant
Legacy_Concept_Name: Endocervical_Carcinoma
has exact synonym: Carcinoma of Endocervix
has exact synonym: Carcinoma of the Endocervix
has exact synonym: Endocervical Adenocarcinoma
has exact synonym: Endocervical Cancer
has exact synonym: Endocervical Carcinoma
in subset: oncotree slim

Axiom
annotated source: Endocervical Carcinoma
annotated property: definition
annotated target: An adenocarcinoma characterized by the presence of malignant glandular epithelium resembling the endocervical epithelium.
def-source: NCI

Axiom
annotated source: Endocervical Carcinoma
annotated property: has exact synonym
annotated target: Carcinoma of Endocervix
term-group: SY
term-source: NCI

Axiom
annotated source: Endocervical Carcinoma
annotated property: has exact synonym
annotated target: Carcinoma of the Endocervix
term-group: SY
term-source: NCI

Axiom
annotated source: Endocervical Carcinoma
annotated property: has exact synonym
annotated target: Endocervical Adenocarcinoma
term-group: SY
term-source: NCI

Axiom
annotated source: Endocervical Carcinoma
annotated property: has exact synonym
annotated target: Endocervical Cancer
term-group: DN
term-source: CTRP

Axiom
annotated source: Endocervical Carcinoma
annotated property: has exact synonym
annotated target: Endocervical Carcinoma
term-group: PT
term-source: NCI

Axiom
annotated source: Endocervical Carcinoma
annotated property: has exact synonym
annotated target: Endocervical Carcinoma
term-group: SY
term-source: NCI
source-code: TCGA
subsource-name: caDSR

Ovarian Sertoli-Leydig Cell Tumor
type: Class
definition: A benign or malignant sex cord-stromal tumor arising from the ovary. It is characterized by the presence of neoplastic Leydig cells. Signs and symptoms include hirsutism, menorrhagia and metrorrhagia. It may be associated with trisomy 8.
Has_NICHD_Parent: NCIT C39966
Concept_In_Subset: NCIT C132009
Concept_In_Subset: NCIT C90259
code: C2880
Semantic_Type: Neoplastic Process
Preferred_Name: Ovarian Sertoli-Leydig Cell Tumor
UMLS_CUI: C0003810
Contributing_Source: NICHD
ALT_DEFINITION: A benign or malignant sex cord-stromal tumor arising from the ovary. It is characterized by the presence of neoplastic Leydig cells. It may be associated with trisomy 8.
ALT_DEFINITION: A rare type of ovarian tumor in which the tumor cells secrete a male sex hormone. This may cause virilization (the appearance of male physical characteristics in females).
Neoplastic_Status: Undetermined
Legacy_Concept_Name: Androblastoma
NICHD_Hierarchy_Term: Ovarian Sertoli-Leydig Cell Tumor
has exact synonym: Androblastoma
has exact synonym: Arrhenoblastoma
has exact synonym: Ovarian Sertoli-Leydig Cell Neoplasm
has exact synonym: Ovarian Sertoli-Leydig Cell Tumor
has exact synonym: Sertoli-Leydig Cell Tumor of Ovary
has exact synonym: Sertoli-Leydig Cell Tumor of the Ovary
has exact synonym: Sertoli-Leydig Neoplasm of Ovary
has exact synonym: Sertoli-Leydig Neoplasm of the Ovary
has exact synonym: Sertoli-Leydig cell tumor of the ovary
has exact synonym: androblastoma
has exact synonym: arrhenoblastoma
in subset: oncotree slim

Axiom
annotated source: Ovarian Sertoli-Leydig Cell Tumor
annotated property: definition
annotated target: A benign or malignant sex cord-stromal tumor arising from the ovary. It is characterized by the presence of neoplastic Leydig cells. Signs and symptoms include hirsutism, menorrhagia and metrorrhagia. It may be associated with trisomy 8.
def-source: NCI

Axiom
annotated source: Ovarian Sertoli-Leydig Cell Tumor
annotated property: ALT_DEFINITION
annotated target: A benign or malignant sex cord-stromal tumor arising from the ovary. It is characterized by the presence of neoplastic Leydig cells. It may be associated with trisomy 8.
def-source: NICHD

Axiom
annotated source: Ovarian Sertoli-Leydig Cell Tumor
annotated property: ALT_DEFINITION
annotated target: A rare type of ovarian tumor in which the tumor cells secrete a male sex hormone. This may cause virilization (the appearance of male physical characteristics in females).
def-source: NCI-GLOSS

Axiom
annotated source: Ovarian Sertoli-Leydig Cell Tumor
annotated property: has exact synonym
annotated target: Androblastoma
term-group: SY
term-source: NCI

Axiom
annotated source: Ovarian Sertoli-Leydig Cell Tumor
annotated property: has exact synonym
annotated target: Arrhenoblastoma
term-group: SY
term-source: NCI

Axiom
annotated source: Ovarian Sertoli-Leydig Cell Tumor
annotated property: has exact synonym
annotated target: Ovarian Sertoli-Leydig Cell Neoplasm
term-group: SY
term-source: NCI

Axiom
annotated source: Ovarian Sertoli-Leydig Cell Tumor
annotated property: has exact synonym
annotated target: Ovarian Sertoli-Leydig Cell Tumor
term-group: PT
term-source: NCI

Axiom
annotated source: Ovarian Sertoli-Leydig Cell Tumor
annotated property: has exact synonym
annotated target: Ovarian Sertoli-Leydig Cell Tumor
term-group: PT
term-source: NICHD

Axiom
annotated source: Ovarian Sertoli-Leydig Cell Tumor
annotated property: has exact synonym
annotated target: Sertoli-Leydig Cell Tumor of Ovary
term-group: SY
term-source: NCI

Axiom
annotated source: Ovarian Sertoli-Leydig Cell Tumor
annotated property: has exact synonym
annotated target: Sertoli-Leydig Cell Tumor of the Ovary
term-group: SY
term-source: NCI

Axiom
annotated source: Ovarian Sertoli-Leydig Cell Tumor
annotated property: has exact synonym
annotated target: Sertoli-Leydig Neoplasm of Ovary
term-group: SY
term-source: NCI

Axiom
annotated source: Ovarian Sertoli-Leydig Cell Tumor
annotated property: has exact synonym
annotated target: Sertoli-Leydig Neoplasm of the Ovary
term-group: SY
term-source: NCI

Axiom
annotated source: Ovarian Sertoli-Leydig Cell Tumor
annotated property: has exact synonym
annotated target: Sertoli-Leydig cell tumor of the ovary
term-group: PT
term-source: NCI-GLOSS
source-code: CDR0000407748

Axiom
annotated source: Ovarian Sertoli-Leydig Cell Tumor
annotated property: has exact synonym
annotated target: androblastoma
term-group: PT
term-source: NCI-GLOSS
source-code: CDR0000407749

Axiom
annotated source: Ovarian Sertoli-Leydig Cell Tumor
annotated property: has exact synonym
annotated target: arrhenoblastoma
term-group: PT
term-source: NCI-GLOSS
source-code: CDR0000407750

Burkitt Lymphoma
type: Class
definition: A highly aggressive lymphoma composed of monomorphic medium-sized B-cells with basophilic cytoplasm and numerous mitotic figures. It is often associated with the presence of Epstein-Barr virus (EBV) and is commonly seen in AIDS patients. Three morphologic variants are recognized: classical Burkitt lymphoma, Burkitt lymphoma with plasmacytoid differentiation, and atypical Burkitt/Burkitt-like lymphoma. All cases express the MYC translocation [t(8;14)]. (WHO, 2001)
Concept_In_Subset: NCIT C116977
Concept_In_Subset: NCIT C126659
code: C2912
Semantic_Type: Neoplastic Process
Display_Name: Burkitt Lymphoma
Preferred_Name: Burkitt Lymphoma
UMLS_CUI: C0006413
Contributing_Source: CTRP
ALT_DEFINITION: An aggressive (fast-growing) type of B-cell non-Hodgkin lymphoma that occurs most often in children and young adults. The disease may affect the jaw, central nervous system, bowel, kidneys, ovaries, or other organs. There are three main types of Burkitt lymphoma (sporadic, endemic, and immunodeficiency related). Sporadic Burkitt lymphoma occurs throughout the world, and endemic Burkitt lymphoma occurs in Africa. Immunodeficiency-related Burkitt lymphoma is most often seen in AIDS patients.
ICD-O-3_Code: 9687/3
Neoplastic_Status: Malignant
Legacy_Concept_Name: Burkitt_s_Lymphoma
has exact synonym: Burkitt Lymphoma
has exact synonym: Burkitt's Lymphoma
has exact synonym: Burkitt's lymphoma
has exact synonym: Small Non-Cleaved Cell Lymphoma, Burkitt's Type
in subset: oncotree slim

Axiom
annotated source: Burkitt Lymphoma
annotated property: definition
annotated target: A highly aggressive lymphoma composed of monomorphic medium-sized B-cells with basophilic cytoplasm and numerous mitotic figures. It is often associated with the presence of Epstein-Barr virus (EBV) and is commonly seen in AIDS patients. Three morphologic variants are recognized: classical Burkitt lymphoma, Burkitt lymphoma with plasmacytoid differentiation, and atypical Burkitt/Burkitt-like lymphoma. All cases express the MYC translocation [t(8;14)]. (WHO, 2001)
def-source: NCI

Axiom
annotated source: Burkitt Lymphoma
annotated property: ALT_DEFINITION
annotated target: An aggressive (fast-growing) type of B-cell non-Hodgkin lymphoma that occurs most often in children and young adults. The disease may affect the jaw, central nervous system, bowel, kidneys, ovaries, or other organs. There are three main types of Burkitt lymphoma (sporadic, endemic, and immunodeficiency related). Sporadic Burkitt lymphoma occurs throughout the world, and endemic Burkitt lymphoma occurs in Africa. Immunodeficiency-related Burkitt lymphoma is most often seen in AIDS patients.
def-source: NCI-GLOSS

Axiom
annotated source: Burkitt Lymphoma
annotated property: has exact synonym
annotated target: Burkitt Lymphoma
term-group: DN
term-source: CTRP

Axiom
annotated source: Burkitt Lymphoma
annotated property: has exact synonym
annotated target: Burkitt Lymphoma
term-group: PT
term-source: NCI

Axiom
annotated source: Burkitt Lymphoma
annotated property: has exact synonym
annotated target: Burkitt Lymphoma
term-group: SY
term-source: NCI
source-code: TCGA
subsource-name: caDSR

Axiom
annotated source: Burkitt Lymphoma
annotated property: has exact synonym
annotated target: Burkitt's Lymphoma
term-group: SY
term-source: NCI

Axiom
annotated source: Burkitt Lymphoma
annotated property: has exact synonym
annotated target: Burkitt's lymphoma
term-group: PT
term-source: NCI-GLOSS
source-code: CDR0000045203

Axiom
annotated source: Burkitt Lymphoma
annotated property: has exact synonym
annotated target: Small Non-Cleaved Cell Lymphoma, Burkitt's Type
term-group: SY
term-source: NCI

Prostate Adenocarcinoma
type: Class
definition: An adenocarcinoma arising from the prostate gland. It is one of the most common malignant tumors afflicting men. The majority of adenocarcinomas arise in the peripheral zone and a minority occurs in the central or the transitional zone of the prostate gland. Grading of prostatic adenocarcinoma predicts disease progression and correlates with survival. Several grading systems have been proposed, of which the Gleason system is the most commonly used. Gleason sums of 2 to 4 represent well-differentiated disease, 5 to 7 moderately differentiated disease and 8 to 10 poorly differentiated disease. Prostatic-specific antigen (PSA) serum test is widely used as a screening test for the early detection of prostatic adenocarcinoma. Treatment options include radical prostatectomy, radiation therapy, androgen ablation and cryotherapy. Watchful waiting or surveillance alone is an option for older patients with low-grade or low-stage disease.
Concept_In_Subset: NCIT C116977
Concept_In_Subset: NCIT C126659
code: C2919
Semantic_Type: Neoplastic Process
Display_Name: Prostate Adenocarcinoma
Preferred_Name: Prostate Adenocarcinoma
UMLS_CUI: C0007112
Contributing_Source: CTRP
Neoplastic_Status: Malignant
Legacy_Concept_Name: Prostate_Adenocarcinoma
has exact synonym: Adenocarcinoma of Prostate
has exact synonym: Adenocarcinoma of the Prostate
has exact synonym: Prostate Adenocarcinoma
in subset: oncotree slim

Axiom
annotated source: Prostate Adenocarcinoma
annotated property: definition
annotated target: An adenocarcinoma arising from the prostate gland. It is one of the most common malignant tumors afflicting men. The majority of adenocarcinomas arise in the peripheral zone and a minority occurs in the central or the transitional zone of the prostate gland. Grading of prostatic adenocarcinoma predicts disease progression and correlates with survival. Several grading systems have been proposed, of which the Gleason system is the most commonly used. Gleason sums of 2 to 4 represent well-differentiated disease, 5 to 7 moderately differentiated disease and 8 to 10 poorly differentiated disease. Prostatic-specific antigen (PSA) serum test is widely used as a screening test for the early detection of prostatic adenocarcinoma. Treatment options include radical prostatectomy, radiation therapy, androgen ablation and cryotherapy. Watchful waiting or surveillance alone is an option for older patients with low-grade or low-stage disease.
def-source: NCI

Axiom
annotated source: Prostate Adenocarcinoma
annotated property: has exact synonym
annotated target: Adenocarcinoma of Prostate
term-group: SY
term-source: NCI

Axiom
annotated source: Prostate Adenocarcinoma
annotated property: has exact synonym
annotated target: Adenocarcinoma of the Prostate
term-group: SY
term-source: NCI

Axiom
annotated source: Prostate Adenocarcinoma
annotated property: has exact synonym
annotated target: Prostate Adenocarcinoma
term-group: DN
term-source: CTRP

Axiom
annotated source: Prostate Adenocarcinoma
annotated property: has exact synonym
annotated target: Prostate Adenocarcinoma
term-group: PT
term-source: NCI

Axiom
annotated source: Prostate Adenocarcinoma
annotated property: has exact synonym
annotated target: Prostate Adenocarcinoma
term-group: SY
term-source: NCI
source-code: TCGA
subsource-name: caDSR

Skin Basal Cell Carcinoma
type: Class
definition: The most frequently seen skin cancer. It arises from basal cells of the epidermis and pilosebaceous units. Clinically it is divided into the following types: nodular, ulcerative, superficial, multicentric, erythematous, and sclerosing or morphea-like. More than 95% of these carcinomas occur in patients over 40. They develop on hair-bearing skin, most commonly on sun-exposed areas. Approximately 85% are found on the head and neck and the remaining 15% on the trunk and extremities. Basal cell carcinoma usually grows in a slow and indolent fashion. However, if untreated, the tumor may invade the subcutaneous fat, skeletal muscle and bone. Distant metastases are rare. Excision, curettage and irradiation cure most basal cell carcinomas.
Concept_In_Subset: NCIT C102905
Concept_In_Subset: NCIT C103112
Concept_In_Subset: NCIT C116977
Concept_In_Subset: NCIT C126659
code: C2921
Semantic_Type: Neoplastic Process
Display_Name: Skin Basal Cell Cancer
Preferred_Name: Skin Basal Cell Carcinoma
UMLS_CUI: C0007117
Contributing_Source: CTEP
Contributing_Source: CTRP
ALT_DEFINITION: Cancer that begins in the lower part of the epidermis (the outer layer of the skin). It may appear as a small white or flesh-colored bump that grows slowly and may bleed. Basal cell cancers are usually found on areas of the body exposed to the sun. Basal cell cancers rarely metastasize (spread) to other parts of the body. They are the most common form of skin cancer.
ICD-O-3_Code: 8090/3
Neoplastic_Status: Malignant
Legacy_Concept_Name: Basal_Cell_Carcinoma
has exact synonym: BCC
has exact synonym: Basal Cell Cancer
has exact synonym: Basal Cell Carcinoma
has exact synonym: Basal Cell Carcinoma of Skin
has exact synonym: Basal Cell Carcinoma of the Skin
has exact synonym: Basal Cell Epithelioma
has exact synonym: Basal Cell Skin Carcinoma
has exact synonym: Basal cell carcinoma
has exact synonym: Skin Basal Cell Cancer
has exact synonym: Skin Basal Cell Carcinoma
has exact synonym: basal cell cancer
has exact synonym: basal cell carcinoma
in subset: oncotree slim

Axiom
annotated source: Skin Basal Cell Carcinoma
annotated property: definition
annotated target: The most frequently seen skin cancer. It arises from basal cells of the epidermis and pilosebaceous units. Clinically it is divided into the following types: nodular, ulcerative, superficial, multicentric, erythematous, and sclerosing or morphea-like. More than 95% of these carcinomas occur in patients over 40. They develop on hair-bearing skin, most commonly on sun-exposed areas. Approximately 85% are found on the head and neck and the remaining 15% on the trunk and extremities. Basal cell carcinoma usually grows in a slow and indolent fashion. However, if untreated, the tumor may invade the subcutaneous fat, skeletal muscle and bone. Distant metastases are rare. Excision, curettage and irradiation cure most basal cell carcinomas.
def-source: NCI

Axiom
annotated source: Skin Basal Cell Carcinoma
annotated property: ALT_DEFINITION
annotated target: Cancer that begins in the lower part of the epidermis (the outer layer of the skin). It may appear as a small white or flesh-colored bump that grows slowly and may bleed. Basal cell cancers are usually found on areas of the body exposed to the sun. Basal cell cancers rarely metastasize (spread) to other parts of the body. They are the most common form of skin cancer.
def-source: NCI-GLOSS

Axiom
annotated source: Skin Basal Cell Carcinoma
annotated property: has exact synonym
annotated target: BCC
term-group: AB
term-source: NCI

Axiom
annotated source: Skin Basal Cell Carcinoma
annotated property: has exact synonym
annotated target: Basal Cell Cancer
term-group: SY
term-source: NCI

Axiom
annotated source: Skin Basal Cell Carcinoma
annotated property: has exact synonym
annotated target: Basal Cell Carcinoma
term-group: SY
term-source: NCI

Axiom
annotated source: Skin Basal Cell Carcinoma
annotated property: has exact synonym
annotated target: Basal Cell Carcinoma of Skin
term-group: SY
term-source: NCI

Axiom
annotated source: Skin Basal Cell Carcinoma
annotated property: has exact synonym
annotated target: Basal Cell Carcinoma of the Skin
term-group: SY
term-source: NCI

Axiom
annotated source: Skin Basal Cell Carcinoma
annotated property: has exact synonym
annotated target: Basal Cell Epithelioma
term-group: SY
term-source: NCI

Axiom
annotated source: Skin Basal Cell Carcinoma
annotated property: has exact synonym
annotated target: Basal Cell Skin Carcinoma
term-group: SY
term-source: NCI

Axiom
annotated source: Skin Basal Cell Carcinoma
annotated property: has exact synonym
annotated target: Basal cell carcinoma
term-group: PT
term-source: CTEP
source-code: 10004146
subsource-name: SDC

Axiom
annotated source: Skin Basal Cell Carcinoma
annotated property: has exact synonym
annotated target: Skin Basal Cell Cancer
term-group: DN
term-source: CTRP

Axiom
annotated source: Skin Basal Cell Carcinoma
annotated property: has exact synonym
annotated target: Skin Basal Cell Carcinoma
term-group: PT
term-source: NCI

Axiom
annotated source: Skin Basal Cell Carcinoma
annotated property: has exact synonym
annotated target: basal cell cancer
term-group: PT
term-source: NCI-GLOSS
source-code: CDR0000667109

Axiom
annotated source: Skin Basal Cell Carcinoma
annotated property: has exact synonym
annotated target: basal cell carcinoma
term-group: PT
term-source: NCI-GLOSS
source-code: CDR0000046515

Ductal Breast Carcinoma In Situ
type: Class
definition: A carcinoma entirely confined to the mammary ducts. It is also known as DCIS. There is no evidence of invasion of the basement membrane. Currently, it is classified into three categories: High-grade DCIS, intermediate-grade DCIS and low-grade DCIS. In this classification the DCIS grade is defined by a combination of nuclear grade, architectural growth pattern and presence of necrosis. The size of the lesion as well as the grade and the clearance margins play a major role in dictating the most appropriate therapy for DCIS.
Concept_In_Subset: NCIT C102905
Concept_In_Subset: NCIT C103040
Concept_In_Subset: NCIT C116977
Concept_In_Subset: NCIT C126659
code: C2924
Semantic_Type: Neoplastic Process
Display_Name: Ductal Breast Carcinoma In Situ
Preferred_Name: Ductal Breast Carcinoma In Situ
UMLS_CUI: C0007124
Contributing_Source: CTEP
Contributing_Source: CTRP
ALT_DEFINITION: A noninvasive condition in which abnormal cells are found in the lining of a breast duct. The abnormal cells have not spread outside the duct to other tissues in the breast. In some cases, ductal carcinoma in situ may become invasive cancer and spread to other tissues, although it is not known at this time how to predict which lesions will become invasive.
ICD-O-3_Code: 8500/2
Neoplastic_Status: Malignant
Legacy_Concept_Name: Ductal_Carcinoma_in_situ_of_the_Breast
has exact synonym: DCIS
has exact synonym: Ductal Breast Carcinoma In Situ
has exact synonym: Ductal Carcinoma In Situ
has exact synonym: Ductal Carcinoma In Situ (DCIS)
has exact synonym: Ductal Carcinoma In Situ of Breast
has exact synonym: Ductal Carcinoma In Situ of the Breast
has exact synonym: Ductal carcinoma in situ
has exact synonym: Intraductal Breast Carcinoma
has exact synonym: Intraductal Carcinoma
has exact synonym: Intraductal Carcinoma of Breast
has exact synonym: Intraductal Carcinoma of the Breast
has exact synonym: Non-Infiltrating Ductal Adenocarcinoma of Breast
has exact synonym: Non-Infiltrating Ductal Adenocarcinoma of the Breast
has exact synonym: Non-Infiltrating Ductal Breast Adenocarcinoma
has exact synonym: Non-Infiltrating Ductal Breast Carcinoma
has exact synonym: Non-Infiltrating Ductal Carcinoma of Breast
has exact synonym: Non-Infiltrating Ductal Carcinoma of the Breast
has exact synonym: Non-Infiltrating Intraductal Adenocarcinoma
has exact synonym: Non-Infiltrating Intraductal Adenocarcinoma of Breast
has exact synonym: Non-Infiltrating Intraductal Adenocarcinoma of the Breast
has exact synonym: Non-Infiltrating Intraductal Breast Adenocarcinoma
has exact synonym: Non-Infiltrating Intraductal Carcinoma
has exact synonym: Non-Invasive Ductal Adenocarcinoma of Breast
has exact synonym: Non-Invasive Ductal Adenocarcinoma of the Breast
has exact synonym: Non-Invasive Ductal Breast Adenocarcinoma
has exact synonym: Non-Invasive Ductal Breast Carcinoma
has exact synonym: Non-Invasive Ductal Carcinoma of Breast
has exact synonym: Non-Invasive Ductal Carcinoma of the Breast
has exact synonym: Non-Invasive Intraductal Adenocarcinoma of Breast
has exact synonym: Non-Invasive Intraductal Adenocarcinoma of the Breast
has exact synonym: Non-Invasive Intraductal Breast Adenocarcinoma
has exact synonym: ductal carcinoma in situ
has exact synonym: intraductal carcinoma
in subset: oncotree slim

Axiom
annotated source: Ductal Breast Carcinoma In Situ
annotated property: definition
annotated target: A carcinoma entirely confined to the mammary ducts. It is also known as DCIS. There is no evidence of invasion of the basement membrane. Currently, it is classified into three categories: High-grade DCIS, intermediate-grade DCIS and low-grade DCIS. In this classification the DCIS grade is defined by a combination of nuclear grade, architectural growth pattern and presence of necrosis. The size of the lesion as well as the grade and the clearance margins play a major role in dictating the most appropriate therapy for DCIS.
def-source: NCI

Axiom
annotated source: Ductal Breast Carcinoma In Situ
annotated property: ALT_DEFINITION
annotated target: A noninvasive condition in which abnormal cells are found in the lining of a breast duct. The abnormal cells have not spread outside the duct to other tissues in the breast. In some cases, ductal carcinoma in situ may become invasive cancer and spread to other tissues, although it is not known at this time how to predict which lesions will become invasive.
def-source: NCI-GLOSS

Axiom
annotated source: Ductal Breast Carcinoma In Situ
annotated property: has exact synonym
annotated target: DCIS
term-group: AB
term-source: NCI

Axiom
annotated source: Ductal Breast Carcinoma In Situ
annotated property: has exact synonym
annotated target: DCIS
term-group: PT
term-source: NCI-GLOSS
source-code: CDR0000044394

Axiom
annotated source: Ductal Breast Carcinoma In Situ
annotated property: has exact synonym
annotated target: Ductal Breast Carcinoma In Situ
term-group: PT
term-source: NCI

Axiom
annotated source: Ductal Breast Carcinoma In Situ
annotated property: has exact synonym
annotated target: Ductal Breast Carcinoma In Situ
term-group: SY
term-source: NCI

Axiom
annotated source: Ductal Breast Carcinoma In Situ
annotated property: has exact synonym
annotated target: Ductal Breast Carcinoma In Situ
term-group: SY
term-source: NCI
source-code: TCGA
subsource-name: caDSR

Axiom
annotated source: Ductal Breast Carcinoma In Situ
annotated property: has exact synonym
annotated target: Ductal Carcinoma In Situ
term-group: SY
term-source: NCI

Axiom
annotated source: Ductal Breast Carcinoma In Situ
annotated property: has exact synonym
annotated target: Ductal Carcinoma In Situ (DCIS)
term-group: DN
term-source: CTRP

Axiom
annotated source: Ductal Breast Carcinoma In Situ
annotated property: has exact synonym
annotated target: Ductal Carcinoma In Situ of Breast
term-group: SY
term-source: NCI

Axiom
annotated source: Ductal Breast Carcinoma In Situ
annotated property: has exact synonym
annotated target: Ductal Carcinoma In Situ of the Breast
term-group: SY
term-source: NCI

Axiom
annotated source: Ductal Breast Carcinoma In Situ
annotated property: has exact synonym
annotated target: Ductal carcinoma in situ
term-group: PT
term-source: CTEP
source-code: 10013806
subsource-name: SDC

Axiom
annotated source: Ductal Breast Carcinoma In Situ
annotated property: has exact synonym
annotated target: Intraductal Breast Carcinoma
term-group: SY
term-source: NCI

Axiom
annotated source: Ductal Breast Carcinoma In Situ
annotated property: has exact synonym
annotated target: Intraductal Carcinoma
term-group: SY
term-source: NCI

Axiom
annotated source: Ductal Breast Carcinoma In Situ
annotated property: has exact synonym
annotated target: Intraductal Carcinoma of Breast
term-group: SY
term-source: NCI

Axiom
annotated source: Ductal Breast Carcinoma In Situ
annotated property: has exact synonym
annotated target: Intraductal Carcinoma of the Breast
term-group: SY
term-source: NCI

Axiom
annotated source: Ductal Breast Carcinoma In Situ
annotated property: has exact synonym
annotated target: Non-Infiltrating Ductal Adenocarcinoma of Breast
term-group: SY
term-source: NCI

Axiom
annotated source: Ductal Breast Carcinoma In Situ
annotated property: has exact synonym
annotated target: Non-Infiltrating Ductal Adenocarcinoma of the Breast
term-group: SY
term-source: NCI

Axiom
annotated source: Ductal Breast Carcinoma In Situ
annotated property: has exact synonym
annotated target: Non-Infiltrating Ductal Breast Adenocarcinoma
term-group: SY
term-source: NCI

Axiom
annotated source: Ductal Breast Carcinoma In Situ
annotated property: has exact synonym
annotated target: Non-Infiltrating Ductal Breast Carcinoma
term-group: SY
term-source: NCI

Axiom
annotated source: Ductal Breast Carcinoma In Situ
annotated property: has exact synonym
annotated target: Non-Infiltrating Ductal Carcinoma of Breast
term-group: SY
term-source: NCI

Axiom
annotated source: Ductal Breast Carcinoma In Situ
annotated property: has exact synonym
annotated target: Non-Infiltrating Ductal Carcinoma of the Breast
term-group: SY
term-source: NCI

Axiom
annotated source: Ductal Breast Carcinoma In Situ
annotated property: has exact synonym
annotated target: Non-Infiltrating Intraductal Adenocarcinoma
term-group: SY
term-source: NCI

Axiom
annotated source: Ductal Breast Carcinoma In Situ
annotated property: has exact synonym
annotated target: Non-Infiltrating Intraductal Adenocarcinoma of Breast
term-group: SY
term-source: NCI

Axiom
annotated source: Ductal Breast Carcinoma In Situ
annotated property: has exact synonym
annotated target: Non-Infiltrating Intraductal Adenocarcinoma of the Breast
term-group: SY
term-source: NCI

Axiom
annotated source: Ductal Breast Carcinoma In Situ
annotated property: has exact synonym
annotated target: Non-Infiltrating Intraductal Breast Adenocarcinoma
term-group: SY
term-source: NCI

Axiom
annotated source: Ductal Breast Carcinoma In Situ
annotated property: has exact synonym
annotated target: Non-Infiltrating Intraductal Carcinoma
term-group: SY
term-source: NCI

Axiom
annotated source: Ductal Breast Carcinoma In Situ
annotated property: has exact synonym
annotated target: Non-Invasive Ductal Adenocarcinoma of Breast
term-group: SY
term-source: NCI

Axiom
annotated source: Ductal Breast Carcinoma In Situ
annotated property: has exact synonym
annotated target: Non-Invasive Ductal Adenocarcinoma of the Breast
term-group: SY
term-source: NCI

Axiom
annotated source: Ductal Breast Carcinoma In Situ
annotated property: has exact synonym
annotated target: Non-Invasive Ductal Breast Adenocarcinoma
term-group: SY
term-source: NCI

Axiom
annotated source: Ductal Breast Carcinoma In Situ
annotated property: has exact synonym
annotated target: Non-Invasive Ductal Breast Carcinoma
term-group: SY
term-source: NCI

Axiom
annotated source: Ductal Breast Carcinoma In Situ
annotated property: has exact synonym
annotated target: Non-Invasive Ductal Carcinoma of Breast
term-group: SY
term-source: NCI

Axiom
annotated source: Ductal Breast Carcinoma In Situ
annotated property: has exact synonym
annotated target: Non-Invasive Ductal Carcinoma of the Breast
term-group: SY
term-source: NCI

Axiom
annotated source: Ductal Breast Carcinoma In Situ
annotated property: has exact synonym
annotated target: Non-Invasive Intraductal Adenocarcinoma of Breast
term-group: SY
term-source: NCI

Axiom
annotated source: Ductal Breast Carcinoma In Situ
annotated property: has exact synonym
annotated target: Non-Invasive Intraductal Adenocarcinoma of the Breast
term-group: SY
term-source: NCI

Axiom
annotated source: Ductal Breast Carcinoma In Situ
annotated property: has exact synonym
annotated target: Non-Invasive Intraductal Breast Adenocarcinoma
term-group: SY
term-source: NCI

Axiom
annotated source: Ductal Breast Carcinoma In Situ
annotated property: has exact synonym
annotated target: ductal carcinoma in situ
term-group: PT
term-source: NCI-GLOSS
source-code: CDR0000045674

Axiom
annotated source: Ductal Breast Carcinoma In Situ
annotated property: has exact synonym
annotated target: intraductal carcinoma
term-group: PT
term-source: NCI-GLOSS
source-code: CDR0000046748

Non-Small Cell Lung Carcinoma
type: Class
definition: A group of at least three distinct histological types of lung cancer, including non-small cell squamous cell carcinoma, adenocarcinoma, and large cell carcinoma. Non-small cell lung carcinomas have a poor response to conventional chemotherapy.
Concept_In_Subset: NCIT C102905
Concept_In_Subset: NCIT C103090
Concept_In_Subset: NCIT C116977
Concept_In_Subset: NCIT C126659
code: C2926
Semantic_Type: Neoplastic Process
Display_Name: Non-Small Cell Lung Cancer
Preferred_Name: Non-Small Cell Lung Carcinoma
UMLS_CUI: C0007131
Contributing_Source: CTEP
Contributing_Source: CTRP
ALT_DEFINITION: A group of lung cancers that are named for the kinds of cells found in the cancer and how the cells look under a microscope. The three main types of non-small cell lung cancer are squamous cell carcinoma, large cell carcinoma, and adenocarcinoma. Non-small cell lung cancer is the most common kind of lung cancer.
Neoplastic_Status: Malignant
Legacy_Concept_Name: Non-Small_Cell_Lung_Carcinoma
has exact synonym: NSCLC
has exact synonym: NSCLC - Non-Small Cell Lung Cancer
has exact synonym: Non Small Cell Lung Cancer NOS
has exact synonym: Non-Small Cell Cancer of Lung
has exact synonym: Non-Small Cell Cancer of the Lung
has exact synonym: Non-Small Cell Carcinoma of Lung
has exact synonym: Non-Small Cell Carcinoma of the Lung
has exact synonym: Non-Small Cell Lung Cancer
has exact synonym: Non-Small Cell Lung Carcinoma
has exact synonym: Non-small cell lung cancer, NOS
has exact synonym: non-small cell lung cancer
in subset: oncotree slim

Axiom
annotated source: Non-Small Cell Lung Carcinoma
annotated property: definition
annotated target: A group of at least three distinct histological types of lung cancer, including non-small cell squamous cell carcinoma, adenocarcinoma, and large cell carcinoma. Non-small cell lung carcinomas have a poor response to conventional chemotherapy.
def-source: NCI

Axiom
annotated source: Non-Small Cell Lung Carcinoma
annotated property: ALT_DEFINITION
annotated target: A group of lung cancers that are named for the kinds of cells found in the cancer and how the cells look under a microscope. The three main types of non-small cell lung cancer are squamous cell carcinoma, large cell carcinoma, and adenocarcinoma. Non-small cell lung cancer is the most common kind of lung cancer.
def-source: NCI-GLOSS

Axiom
annotated source: Non-Small Cell Lung Carcinoma
annotated property: has exact synonym
annotated target: NSCLC
term-group: AB
term-source: NCI

Axiom
annotated source: Non-Small Cell Lung Carcinoma
annotated property: has exact synonym
annotated target: NSCLC - Non-Small Cell Lung Cancer
term-group: SY
term-source: NCI

Axiom
annotated source: Non-Small Cell Lung Carcinoma
annotated property: has exact synonym
annotated target: Non Small Cell Lung Cancer NOS
term-group: SY
term-source: NCI

Axiom
annotated source: Non-Small Cell Lung Carcinoma
annotated property: has exact synonym
annotated target: Non-Small Cell Cancer of Lung
term-group: SY
term-source: NCI

Axiom
annotated source: Non-Small Cell Lung Carcinoma
annotated property: has exact synonym
annotated target: Non-Small Cell Cancer of the Lung
term-group: SY
term-source: NCI

Axiom
annotated source: Non-Small Cell Lung Carcinoma
annotated property: has exact synonym
annotated target: Non-Small Cell Carcinoma of Lung
term-group: SY
term-source: NCI

Axiom
annotated source: Non-Small Cell Lung Carcinoma
annotated property: has exact synonym
annotated target: Non-Small Cell Carcinoma of the Lung
term-group: SY
term-source: NCI

Axiom
annotated source: Non-Small Cell Lung Carcinoma
annotated property: has exact synonym
annotated target: Non-Small Cell Lung Cancer
term-group: DN
term-source: CTRP

Axiom
annotated source: Non-Small Cell Lung Carcinoma
annotated property: has exact synonym
annotated target: Non-Small Cell Lung Cancer
term-group: SY
term-source: NCI

Axiom
annotated source: Non-Small Cell Lung Carcinoma
annotated property: has exact synonym
annotated target: Non-Small Cell Lung Carcinoma
term-group: PT
term-source: NCI

Axiom
annotated source: Non-Small Cell Lung Carcinoma
annotated property: has exact synonym
annotated target: Non-small cell lung cancer, NOS
term-group: PT
term-source: CTEP
source-code: 10029514
subsource-name: SDC

Axiom
annotated source: Non-Small Cell Lung Carcinoma
annotated property: has exact synonym
annotated target: non-small cell lung cancer
term-group: PT
term-source: NCI-GLOSS
source-code: CDR0000045323

Chondroblastoma
type: Class
definition: A benign, chondroid-producing, well-circumscribed, lytic neoplasm usually arising from the epiphysis of long bones. It is characterized by the presence of chondroblasts, osteoclast-like giant cells, chondroid formation, calcification, and mitotic activity. In aggressive cases, there is rearrangement of the 8q21 chromosome band. It occurs most frequently in children and young adults and rarely metastasizes.
Concept_In_Subset: NCIT C126659
code: C2945
Semantic_Type: Neoplastic Process
Preferred_Name: Chondroblastoma
UMLS_CUI: C0008441
ICD-O-3_Code: 9230/0
Neoplastic_Status: Benign
Legacy_Concept_Name: Chondroblastoma
has exact synonym: Chondroblastoma
in subset: oncotree slim

Axiom
annotated source: Chondroblastoma
annotated property: definition
annotated target: A benign, chondroid-producing, well-circumscribed, lytic neoplasm usually arising from the epiphysis of long bones. It is characterized by the presence of chondroblasts, osteoclast-like giant cells, chondroid formation, calcification, and mitotic activity. In aggressive cases, there is rearrangement of the 8q21 chromosome band. It occurs most frequently in children and young adults and rarely metastasizes.
def-source: NCI

Axiom
annotated source: Chondroblastoma
annotated property: has exact synonym
annotated target: Chondroblastoma
term-group: PT
term-source: NCI

Chondrosarcoma
type: Class
definition: A malignant cartilaginous matrix-producing mesenchymal neoplasm arising from the bone and soft tissue. It usually affects middle-aged to elderly adults. The pelvic bones, ribs, shoulder girdle, and long bones are the most common sites of involvement. Most chondrosarcomas arise de novo, but some may develop in a preexisting benign cartilaginous lesion.
Concept_In_Subset: NCIT C102905
Concept_In_Subset: NCIT C103037
Concept_In_Subset: NCIT C116977
Concept_In_Subset: NCIT C126659
Concept_In_Subset: NCIT C61410
Concept_In_Subset: NCIT C77526
Concept_In_Subset: NCIT C88025
code: C2946
Semantic_Type: Neoplastic Process
Display_Name: Chondrosarcoma
Preferred_Name: Chondrosarcoma
UMLS_CUI: C0008479
Contributing_Source: CDISC
Contributing_Source: CTEP
Contributing_Source: CTRP
ALT_DEFINITION: A malignant mesenchymal neoplasm arising from cartilage-forming tissues.
ALT_DEFINITION: A type of cancer that forms in bone cartilage. It usually starts in the pelvis (between the hip bones), the shoulder, the ribs, or at the ends of the long bones of the arms and legs. A rare type of chondrosarcoma called extraskeletal chondrosarcoma does not form in bone cartilage. Instead, it forms in the soft tissues of the upper part of the arms and legs. Chondrosarcoma can occur at any age but is more common in people older than 40 years. It is a type of bone cancer.
ICD-O-3_Code: 9220/3
Neoplastic_Status: Malignant
Legacy_Concept_Name: Chondrosarcoma
has exact synonym: CHONDROSARCOMA, MALIGNANT
has exact synonym: Chondrosarcoma
has exact synonym: chondrosarcoma
in subset: oncotree slim

Axiom
annotated source: Chondrosarcoma
annotated property: definition
annotated target: A malignant cartilaginous matrix-producing mesenchymal neoplasm arising from the bone and soft tissue. It usually affects middle-aged to elderly adults. The pelvic bones, ribs, shoulder girdle, and long bones are the most common sites of involvement. Most chondrosarcomas arise de novo, but some may develop in a preexisting benign cartilaginous lesion.
def-source: NCI

Axiom
annotated source: Chondrosarcoma
annotated property: ALT_DEFINITION
annotated target: A malignant mesenchymal neoplasm arising from cartilage-forming tissues.
def-source: CDISC

Axiom
annotated source: Chondrosarcoma
annotated property: ALT_DEFINITION
annotated target: A type of cancer that forms in bone cartilage. It usually starts in the pelvis (between the hip bones), the shoulder, the ribs, or at the ends of the long bones of the arms and legs. A rare type of chondrosarcoma called extraskeletal chondrosarcoma does not form in bone cartilage. Instead, it forms in the soft tissues of the upper part of the arms and legs. Chondrosarcoma can occur at any age but is more common in people older than 40 years. It is a type of bone cancer.
def-source: NCI-GLOSS

Axiom
annotated source: Chondrosarcoma
annotated property: has exact synonym
annotated target: CHONDROSARCOMA, MALIGNANT
term-group: PT
term-source: CDISC

Axiom
annotated source: Chondrosarcoma
annotated property: has exact synonym
annotated target: Chondrosarcoma
term-group: PT
term-source: CTEP
source-code: 10008737
subsource-name: SDC

Axiom
annotated source: Chondrosarcoma
annotated property: has exact synonym
annotated target: Chondrosarcoma
term-group: PT
term-source: CTRP

Axiom
annotated source: Chondrosarcoma
annotated property: has exact synonym
annotated target: Chondrosarcoma
term-group: PT
term-source: NCI

Axiom
annotated source: Chondrosarcoma
annotated property: has exact synonym
annotated target: chondrosarcoma
term-group: PT
term-source: NCI-GLOSS
source-code: CDR0000045221

Chordoma
type: Class
definition: A malignant bone tumor arising from the remnants of the fetal notochord. Although it can occur at all ages, it is more frequently seen in middle-aged adults. The most frequent sites of involvement are the sacrococcygeal area, spheno-occipital area, and cervico-thoraco-lumbar spine. Microscopically, chordomas are composed of cells that form cords and lobules, separated by mucoid intercellular tissue. Some of the cells are large (physaliphorous) and have vacuolated cytoplasm and prominent vesicular nuclei. Other tumor cells are small with small nuclei without visible nucleoli. Chordomas tend to recur and may metastasize. The most common sites of metastasis are the skin and bone.
Concept_In_Subset: NCIT C116977
Concept_In_Subset: NCIT C126659
Concept_In_Subset: NCIT C61410
Concept_In_Subset: NCIT C77526
Concept_In_Subset: NCIT C88025
code: C2947
Semantic_Type: Neoplastic Process
Display_Name: Chordoma
Preferred_Name: Chordoma
UMLS_CUI: C0008487
Contributing_Source: CDISC
Contributing_Source: CTRP
ALT_DEFINITION: A malignant bone neoplasm arising from the remnants of the fetal notochord.
ALT_DEFINITION: A type of bone cancer that usually starts in the lower spinal column or at the base of the skull.
ICD-O-3_Code: 9370/3
Neoplastic_Status: Malignant
Legacy_Concept_Name: Chordoma
has exact synonym: CHORDOMA, MALIGNANT
has exact synonym: Chordoma
has exact synonym: chordoma
in subset: oncotree slim

Axiom
annotated source: Chordoma
annotated property: definition
annotated target: A malignant bone tumor arising from the remnants of the fetal notochord. Although it can occur at all ages, it is more frequently seen in middle-aged adults. The most frequent sites of involvement are the sacrococcygeal area, spheno-occipital area, and cervico-thoraco-lumbar spine. Microscopically, chordomas are composed of cells that form cords and lobules, separated by mucoid intercellular tissue. Some of the cells are large (physaliphorous) and have vacuolated cytoplasm and prominent vesicular nuclei. Other tumor cells are small with small nuclei without visible nucleoli. Chordomas tend to recur and may metastasize. The most common sites of metastasis are the skin and bone.
def-source: NCI

Axiom
annotated source: Chordoma
annotated property: ALT_DEFINITION
annotated target: A malignant bone neoplasm arising from the remnants of the fetal notochord.
def-source: CDISC

Axiom
annotated source: Chordoma
annotated property: ALT_DEFINITION
annotated target: A type of bone cancer that usually starts in the lower spinal column or at the base of the skull.
def-source: NCI-GLOSS

Axiom
annotated source: Chordoma
annotated property: has exact synonym
annotated target: CHORDOMA, MALIGNANT
term-group: PT
term-source: CDISC

Axiom
annotated source: Chordoma
annotated property: has exact synonym
annotated target: Chordoma
term-group: PT
term-source: CTRP

Axiom
annotated source: Chordoma
annotated property: has exact synonym
annotated target: Chordoma
term-group: PT
term-source: NCI

Axiom
annotated source: Chordoma
annotated property: has exact synonym
annotated target: chordoma
term-group: PT
term-source: NCI-GLOSS
source-code: CDR0000045297

Choriocarcinoma
type: Class
definition: An aggressive malignant tumor arising from trophoblastic cells. The vast majority of cases arise in the uterus and represent gestational choriocarcinomas that derive from placental trophoblastic cells. Approximately half of the cases develop from a complete hydatidiform mole. A minority of cases arise in the testis or the ovaries. There is often marked elevation of human chorionic gonadotropin (hCG) in the blood. Choriocarcinomas disseminate rapidly through the hematogenous route; the lungs are most frequently affected.
Concept_In_Subset: NCIT C126659
Concept_In_Subset: NCIT C61410
Concept_In_Subset: NCIT C77526
Concept_In_Subset: NCIT C88025
code: C2948
Semantic_Type: Neoplastic Process
Preferred_Name: Choriocarcinoma
UMLS_CUI: C0008497
Contributing_Source: CDISC
ALT_DEFINITION: A malignant neoplasm arising from placental trophoblast cells. They generally arise in the uterus.
ALT_DEFINITION: A malignant, fast-growing tumor that develops from trophoblastic cells (cells that help an embryo attach to the uterus and help form the placenta). Almost all choriocarcinomas form in the uterus after fertilization of an egg by a sperm, but a small number form in a testis or an ovary. Choriocarcinomas spread through the blood to other organs, especially the lungs. They are a type of gestational trophoblastic disease.
ICD-O-3_Code: 9100/3
Neoplastic_Status: Malignant
Legacy_Concept_Name: Choriocarcinoma
has exact synonym: CHORIOCARCINOMA, MALIGNANT
has exact synonym: Choriocarcinoma
has exact synonym: Chorioepithelioma
has exact synonym: chorioblastoma
has exact synonym: choriocarcinoma
has exact synonym: chorioepithelioma
has exact synonym: chorionic carcinoma
in subset: oncotree slim

Axiom
annotated source: Choriocarcinoma
annotated property: definition
annotated target: An aggressive malignant tumor arising from trophoblastic cells. The vast majority of cases arise in the uterus and represent gestational choriocarcinomas that derive from placental trophoblastic cells. Approximately half of the cases develop from a complete hydatidiform mole. A minority of cases arise in the testis or the ovaries. There is often marked elevation of human chorionic gonadotropin (hCG) in the blood. Choriocarcinomas disseminate rapidly through the hematogenous route; the lungs are most frequently affected.
def-source: NCI

Axiom
annotated source: Choriocarcinoma
annotated property: ALT_DEFINITION
annotated target: A malignant neoplasm arising from placental trophoblast cells. They generally arise in the uterus.
def-source: CDISC

Axiom
annotated source: Choriocarcinoma
annotated property: ALT_DEFINITION
annotated target: A malignant, fast-growing tumor that develops from trophoblastic cells (cells that help an embryo attach to the uterus and help form the placenta). Almost all choriocarcinomas form in the uterus after fertilization of an egg by a sperm, but a small number form in a testis or an ovary. Choriocarcinomas spread through the blood to other organs, especially the lungs. They are a type of gestational trophoblastic disease.
def-source: NCI-GLOSS

Axiom
annotated source: Choriocarcinoma
annotated property: has exact synonym
annotated target: CHORIOCARCINOMA, MALIGNANT
term-group: PT
term-source: CDISC

Axiom
annotated source: Choriocarcinoma
annotated property: has exact synonym
annotated target: Choriocarcinoma
term-group: DN
term-source: CTRP

Axiom
annotated source: Choriocarcinoma
annotated property: has exact synonym
annotated target: Choriocarcinoma
term-group: PT
term-source: CTRP

Axiom
annotated source: Choriocarcinoma
annotated property: has exact synonym
annotated target: Choriocarcinoma
term-group: PT
term-source: NCI

Axiom
annotated source: Choriocarcinoma
annotated property: has exact synonym
annotated target: Choriocarcinoma
term-group: SY
term-source: NCI
source-code: TCGA
subsource-name: caDSR

Axiom
annotated source: Choriocarcinoma
annotated property: has exact synonym
annotated target: Chorioepithelioma
term-group: SY
term-source: CDISC

Axiom
annotated source: Choriocarcinoma
annotated property: has exact synonym
annotated target: Chorioepithelioma
term-group: SY
term-source: NCI

Axiom
annotated source: Choriocarcinoma
annotated property: has exact synonym
annotated target: chorioblastoma
term-group: PT
term-source: NCI-GLOSS
source-code: CDR0000554834

Axiom
annotated source: Choriocarcinoma
annotated property: has exact synonym
annotated target: choriocarcinoma
term-group: PT
term-source: NCI-GLOSS
source-code: CDR0000046753

Axiom
annotated source: Choriocarcinoma
annotated property: has exact synonym
annotated target: chorioepithelioma
term-group: PT
term-source: NCI-GLOSS
source-code: CDR0000554835

Axiom
annotated source: Choriocarcinoma
annotated property: has exact synonym
annotated target: chorionic carcinoma
term-group: PT
term-source: NCI-GLOSS
source-code: CDR0000554836

Adenoid Cystic Carcinoma
type: Class
definition: A malignant tumor arising from the epithelial cells. Microscopically, the neoplastic epithelial cells form cylindrical spatial configurations (cribriform or classic type of adenoid cystic carcinoma), cordlike structures (tubular type of adenoid cystic carcinoma), or solid structures (basaloid variant of adenoid cystic carcinoma). Adenoid cystic carcinomas mostly occur in the salivary glands. Other primary sites of involvement include the lacrimal gland, the larynx, and the lungs. Adenoid cystic carcinomas spread along nerve sheaths, resulting in severe pain, and they tend to recur. Lymph node metastases are unusual; hematogenous tumor spread is characteristic.
Concept_In_Subset: NCIT C126659
code: C2970
Semantic_Type: Neoplastic Process
Preferred_Name: Adenoid Cystic Carcinoma
UMLS_CUI: C0010606
ALT_DEFINITION: A rare type of cancer that usually begins in the salivary glands.
ICD-O-3_Code: 8200/3
Neoplastic_Status: Malignant
Legacy_Concept_Name: Adenoid_Cystic_Carcinoma
has exact synonym: Adenocystic Carcinoma
has exact synonym: Adenoid Cystic Carcinoma
has exact synonym: Cylindroid Adenocarcinoma
has exact synonym: adenoid cystic cancer
in subset: oncotree slim

Axiom
annotated source: Adenoid Cystic Carcinoma
annotated property: definition
annotated target: A malignant tumor arising from the epithelial cells. Microscopically, the neoplastic epithelial cells form cylindrical spatial configurations (cribriform or classic type of adenoid cystic carcinoma), cordlike structures (tubular type of adenoid cystic carcinoma), or solid structures (basaloid variant of adenoid cystic carcinoma). Adenoid cystic carcinomas mostly occur in the salivary glands. Other primary sites of involvement include the lacrimal gland, the larynx, and the lungs. Adenoid cystic carcinomas spread along nerve sheaths, resulting in severe pain, and they tend to recur. Lymph node metastases are unusual; hematogenous tumor spread is characteristic.
def-source: NCI

Axiom
annotated source: Adenoid Cystic Carcinoma
annotated property: ALT_DEFINITION
annotated target: A rare type of cancer that usually begins in the salivary glands.
def-source: NCI-GLOSS

Axiom
annotated source: Adenoid Cystic Carcinoma
annotated property: has exact synonym
annotated target: Adenocystic Carcinoma
term-group: SY
term-source: NCI

Axiom
annotated source: Adenoid Cystic Carcinoma
annotated property: has exact synonym
annotated target: Adenoid Cystic Carcinoma
term-group: PT
term-source: NCI

Axiom
annotated source: Adenoid Cystic Carcinoma
annotated property: has exact synonym
annotated target: Adenoid Cystic Carcinoma
term-group: SY
term-source: NCI
source-code: TCGA
subsource-name: caDSR

Axiom
annotated source: Adenoid Cystic Carcinoma
annotated property: has exact synonym
annotated target: Cylindroid Adenocarcinoma
term-group: SY
term-source: NCI

Axiom
annotated source: Adenoid Cystic Carcinoma
annotated property: has exact synonym
annotated target: adenoid cystic cancer
term-group: PT
term-source: NCI-GLOSS
source-code: CDR0000046022

Yolk Sac Tumor
type: Class
definition: A non-seminomatous malignant germ cell tumor composed of primitive germ cells. It is the most common malignant germ cell tumor in the pediatric population. It occurs in the infant testis, ovary, sacrococcygeal region, vagina, uterus, prostate, abdomen, liver, retroperitoneum, thorax, and pineal/third ventricle. The tumor mimics the yolk sac of the embryo and produces alpha-fetoprotein (AFP). Treatment includes: surgical resection, radiation, and chemotherapy. This tumor is very responsive to chemotherapy regimens that include cisplatinum.
Concept_In_Subset: NCIT C126659
Concept_In_Subset: NCIT C61410
Concept_In_Subset: NCIT C77526
Concept_In_Subset: NCIT C88025
code: C3011
Semantic_Type: Neoplastic Process
Preferred_Name: Yolk Sac Tumor
UMLS_CUI: C0014145
Contributing_Source: CDISC
ALT_DEFINITION: A non-seminomatous malignant germ cell tumor composed of primitive germ cells and which produce an eosinophilic substance (alpha-fetoprotein).
ICD-O-3_Code: 9071/3
Neoplastic_Status: Malignant
Legacy_Concept_Name: Yolk_Sac_Tumor
has exact synonym: Endodermal Sinus Neoplasm
has exact synonym: Endodermal Sinus Tumor
has exact synonym: YOLK SAC TUMOR, MALIGNANT
has exact synonym: Yolk Sac Neoplasm
has exact synonym: Yolk Sac Tumor
has exact synonym: Yolk Sac Tumor Site Unspecified
has exact synonym: Yolk Sac Tumour Site Unspecified
in subset: oncotree slim

Axiom
annotated source: Yolk Sac Tumor
annotated property: definition
annotated target: A non-seminomatous malignant germ cell tumor composed of primitive germ cells. It is the most common malignant germ cell tumor in the pediatric population. It occurs in the infant testis, ovary, sacrococcygeal region, vagina, uterus, prostate, abdomen, liver, retroperitoneum, thorax, and pineal/third ventricle. The tumor mimics the yolk sac of the embryo and produces alpha-fetoprotein (AFP). Treatment includes: surgical resection, radiation, and chemotherapy. This tumor is very responsive to chemotherapy regimens that include cisplatinum.
def-source: NCI

Axiom
annotated source: Yolk Sac Tumor
annotated property: ALT_DEFINITION
annotated target: A non-seminomatous malignant germ cell tumor composed of primitive germ cells and which produce an eosinophilic substance (alpha-fetoprotein).
def-source: CDISC

Axiom
annotated source: Yolk Sac Tumor
annotated property: has exact synonym
annotated target: Endodermal Sinus Neoplasm
term-group: SY
term-source: CDISC

Axiom
annotated source: Yolk Sac Tumor
annotated property: has exact synonym
annotated target: Endodermal Sinus Neoplasm
term-group: SY
term-source: NCI

Axiom
annotated source: Yolk Sac Tumor
annotated property: has exact synonym
annotated target: Endodermal Sinus Tumor
term-group: SY
term-source: CDISC

Axiom
annotated source: Yolk Sac Tumor
annotated property: has exact synonym
annotated target: Endodermal Sinus Tumor
term-group: SY
term-source: NCI

Axiom
annotated source: Yolk Sac Tumor
annotated property: has exact synonym
annotated target: YOLK SAC TUMOR, MALIGNANT
term-group: PT
term-source: CDISC

Axiom
annotated source: Yolk Sac Tumor
annotated property: has exact synonym
annotated target: Yolk Sac Neoplasm
term-group: SY
term-source: CDISC

Axiom
annotated source: Yolk Sac Tumor
annotated property: has exact synonym
annotated target: Yolk Sac Neoplasm
term-group: SY
term-source: NCI

Axiom
annotated source: Yolk Sac Tumor
annotated property: has exact synonym
annotated target: Yolk Sac Tumor
term-group: DN
term-source: CTRP

Axiom
annotated source: Yolk Sac Tumor
annotated property: has exact synonym
annotated target: Yolk Sac Tumor
term-group: PT
term-source: CTRP

Axiom
annotated source: Yolk Sac Tumor
annotated property: has exact synonym
annotated target: Yolk Sac Tumor
term-group: PT
term-source: NCI

Axiom
annotated source: Yolk Sac Tumor
annotated property: has exact synonym
annotated target: Yolk Sac Tumor
term-group: SY
term-source: NCI
source-code: TCGA
subsource-name: caDSR

Axiom
annotated source: Yolk Sac Tumor
annotated property: has exact synonym
annotated target: Yolk Sac Tumor Site Unspecified
term-group: SY
term-source: CDISC

Axiom
annotated source: Yolk Sac Tumor
annotated property: has exact synonym
annotated target: Yolk Sac Tumour Site Unspecified
term-group: SY
term-source: NCI

Ependymoma
type: Class
subclass of: Ependymal Tumor
definition: A WHO grade II, slow growing tumor of children and young adults, usually located intraventricularly. It is the most common ependymal neoplasm. It often causes clinical symptoms by blocking cerebrospinal fluid pathways. Key histological features include perivascular pseudorosettes and ependymal rosettes. (WHO)
Has_NICHD_Parent: NCIT C3268
Concept_In_Subset: NCIT C102905
Concept_In_Subset: NCIT C103047
Concept_In_Subset: NCIT C118464
Concept_In_Subset: NCIT C126659
Concept_In_Subset: NCIT C90259
code: C3017
Semantic_Type: Neoplastic Process
Display_Name: Ependymoma
Preferred_Name: Ependymoma
UMLS_CUI: C0014474
Contributing_Source: CTEP
Contributing_Source: MedDRA
Contributing_Source: NICHD
ALT_DEFINITION: A malignant neoplasm arising from ependymal cells that line the ventricles of the brain and the central canal of the spinal cord.
ALT_DEFINITION: A type of brain tumor that begins in cells lining the spinal cord central canal (fluid-filled space down the center) or the ventricles (fluid-filled spaces of the brain). Ependymomas may also form in the choroid plexus (tissue in the ventricles that makes cerebrospinal fluid).
ICD-O-3_Code: 9391/3
Neoplastic_Status: Undetermined
Legacy_Concept_Name: Ependymoma
NICHD_Hierarchy_Term: Ependymoma
has exact synonym: Ependymoma
has exact synonym: Ependymoma, NOS
has exact synonym: WHO Grade II Ependymal Neoplasm
has exact synonym: WHO Grade II Ependymal Tumor
has exact synonym: ependymoma
in subset: oncotree slim

Axiom
annotated source: Ependymoma
annotated property: definition
annotated target: A WHO grade II, slow growing tumor of children and young adults, usually located intraventricularly. It is the most common ependymal neoplasm. It often causes clinical symptoms by blocking cerebrospinal fluid pathways. Key histological features include perivascular pseudorosettes and ependymal rosettes. (WHO)
def-source: NCI
attr: from WHO

Axiom
annotated source: Ependymoma
annotated property: ALT_DEFINITION
annotated target: A malignant neoplasm arising from ependymal cells that line the ventricles of the brain and the central canal of the spinal cord.
def-source: NICHD

Axiom
annotated source: Ependymoma
annotated property: ALT_DEFINITION
annotated target: A type of brain tumor that begins in cells lining the spinal cord central canal (fluid-filled space down the center) or the ventricles (fluid-filled spaces of the brain). Ependymomas may also form in the choroid plexus (tissue in the ventricles that makes cerebrospinal fluid).
def-source: NCI-GLOSS

Axiom
annotated source: Ependymoma
annotated property: has exact synonym
annotated target: Ependymoma
term-group: PT
term-source: NCI

Axiom
annotated source: Ependymoma
annotated property: has exact synonym
annotated target: Ependymoma
term-group: PT
term-source: NICHD

Axiom
annotated source: Ependymoma
annotated property: has exact synonym
annotated target: Ependymoma
term-group: SY
term-source: NCI
source-code: TCGA
subsource-name: caDSR

Axiom
annotated source: Ependymoma
annotated property: has exact synonym
annotated target: Ependymoma, NOS
term-group: PT
term-source: CTEP
source-code: 10014967
subsource-name: SDC

Axiom
annotated source: Ependymoma
annotated property: has exact synonym
annotated target: WHO Grade II Ependymal Neoplasm
term-group: SY
term-source: NCI

Axiom
annotated source: Ependymoma
annotated property: has exact synonym
annotated target: WHO Grade II Ependymal Tumor
term-group: SY
term-source: NCI

Axiom
annotated source: Ependymoma
annotated property: has exact synonym
annotated target: ependymoma
term-group: PT
term-source: NCI-GLOSS
source-code: CDR0000046432

Fibrosarcoma
type: Class
definition: A malignant mesenchymal fibroblastic neoplasm affecting the soft tissue and bone.
Has_NICHD_Parent: NCIT C9118
Concept_In_Subset: NCIT C102905
Concept_In_Subset: NCIT C103117
Concept_In_Subset: NCIT C126659
Concept_In_Subset: NCIT C61410
Concept_In_Subset: NCIT C77526
Concept_In_Subset: NCIT C88025
Concept_In_Subset: NCIT C90259
Concept_In_Subset: NCIT C99147
code: C3043
Semantic_Type: Neoplastic Process
Preferred_Name: Fibrosarcoma
UMLS_CUI: C0016057
Contributing_Source: CDISC
Contributing_Source: CTEP
Contributing_Source: NICHD
ALT_DEFINITION: A malignant mesenchymal neoplasm of the soft tissue and bone.
ICD-O-3_Code: 8810/3
Neoplastic_Status: Malignant
Legacy_Concept_Name: Fibrosarcoma
NICHD_Hierarchy_Term: Fibrosarcoma
has exact synonym: FIBROSARCOMA, MALIGNANT
has exact synonym: Fibrosarcoma
has exact synonym: Fibrosarcoma (excluding infantile fibrosarcoma)
has exact synonym: Fibrosarcoma - not infantile
has exact synonym: Malignant Fibromatous Neoplasm
has exact synonym: fibrosarcoma
in subset: oncotree slim

Axiom
annotated source: Fibrosarcoma
annotated property: definition
annotated target: A malignant mesenchymal fibroblastic neoplasm affecting the soft tissue and bone.
def-source: NCI

Axiom
annotated source: Fibrosarcoma
annotated property: ALT_DEFINITION
annotated target: A malignant mesenchymal neoplasm of the soft tissue and bone.
def-source: CDISC

Axiom
annotated source: Fibrosarcoma
annotated property: has exact synonym
annotated target: FIBROSARCOMA, MALIGNANT
term-group: PT
term-source: CDISC

Axiom
annotated source: Fibrosarcoma
annotated property: has exact synonym
annotated target: Fibrosarcoma
term-group: PT
term-source: NCI

Axiom
annotated source: Fibrosarcoma
annotated property: has exact synonym
annotated target: Fibrosarcoma
term-group: PT
term-source: NICHD

Axiom
annotated source: Fibrosarcoma
annotated property: has exact synonym
annotated target: Fibrosarcoma (excluding infantile fibrosarcoma)
term-group: PT
term-source: CTEP
source-code: 10016637
subsource-name: SDC

Axiom
annotated source: Fibrosarcoma
annotated property: has exact synonym
annotated target: Fibrosarcoma - not infantile
term-group: SY
term-source: CTEP
source-code: 10016637
subsource-name: SDC

Axiom
annotated source: Fibrosarcoma
annotated property: has exact synonym
annotated target: Malignant Fibromatous Neoplasm
term-group: SY
term-source: NICHD

Axiom
annotated source: Fibrosarcoma
annotated property: has exact synonym
annotated target: fibrosarcoma
term-group: PT
term-source: NCI-GLOSS
source-code: CDR0000046403

Glioblastoma
type: Class
definition: The most malignant astrocytic tumor (WHO grade IV). It is composed of poorly differentiated neoplastic astrocytes and it is characterized by the presence of cellular polymorphism, nuclear atypia, brisk mitotic activity, vascular thrombosis, microvascular proliferation and necrosis. It typically affects adults and is preferentially located in the cerebral hemispheres. It may develop from diffuse astrocytoma WHO grade II or anaplastic astrocytoma (secondary glioblastoma, IDH-mutant), but more frequently, it manifests after a short clinical history de novo, without evidence of a less malignant precursor lesion (primary glioblastoma, IDH- wildtype). (Adapted from WHO)
Concept_In_Subset: NCIT C102905
Concept_In_Subset: NCIT C103031
Concept_In_Subset: NCIT C126659
code: C3058
Semantic_Type: Neoplastic Process
Preferred_Name: Glioblastoma
UMLS_CUI: C0017636
Contributing_Source: CTEP
ALT_DEFINITION: A fast-growing type of central nervous system tumor that forms from glial (supportive) tissue of the brain and spinal cord and has cells that look very different from normal cells. GBM usually occurs in adults and affects the brain more often than the spinal cord.
ICD-O-3_Code: 9440/3
Neoplastic_Status: Malignant
Legacy_Concept_Name: Glioblastoma
has exact synonym: GBM
has exact synonym: GBM (Glioblastoma)
has exact synonym: Glioblastoma
has exact synonym: Glioblastoma Multiforme
has exact synonym: Glioblastoma multiforme
has exact synonym: Grade IV Astrocytic Neoplasm
has exact synonym: Grade IV Astrocytic Tumor
has exact synonym: Spongioblastoma Multiforme
has exact synonym: WHO Grade IV Glioma
has exact synonym: glioblastoma
has exact synonym: glioblastoma multiforme
has exact synonym: grade IV astrocytoma
in subset: oncotree slim

Axiom
annotated source: Glioblastoma
annotated property: definition
annotated target: The most malignant astrocytic tumor (WHO grade IV). It is composed of poorly differentiated neoplastic astrocytes and it is characterized by the presence of cellular polymorphism, nuclear atypia, brisk mitotic activity, vascular thrombosis, microvascular proliferation and necrosis. It typically affects adults and is preferentially located in the cerebral hemispheres. It may develop from diffuse astrocytoma WHO grade II or anaplastic astrocytoma (secondary glioblastoma, IDH-mutant), but more frequently, it manifests after a short clinical history de novo, without evidence of a less malignant precursor lesion (primary glioblastoma, IDH- wildtype). (Adapted from WHO)
def-source: NCI

Axiom
annotated source: Glioblastoma
annotated property: ALT_DEFINITION
annotated target: A fast-growing type of central nervous system tumor that forms from glial (supportive) tissue of the brain and spinal cord and has cells that look very different from normal cells. GBM usually occurs in adults and affects the brain more often than the spinal cord.
def-source: NCI-GLOSS

Axiom
annotated source: Glioblastoma
annotated property: has exact synonym
annotated target: GBM
term-group: AB
term-source: NCI

Axiom
annotated source: Glioblastoma
annotated property: has exact synonym
annotated target: GBM
term-group: PT
term-source: NCI-GLOSS
source-code: CDR0000539131

Axiom
annotated source: Glioblastoma
annotated property: has exact synonym
annotated target: GBM (Glioblastoma)
term-group: SY
term-source: NCI

Axiom
annotated source: Glioblastoma
annotated property: has exact synonym
annotated target: Glioblastoma
term-group: PT
term-source: NCI

Axiom
annotated source: Glioblastoma
annotated property: has exact synonym
annotated target: Glioblastoma
term-group: SY
term-source: NCI
source-code: TCGA
subsource-name: caDSR

Axiom
annotated source: Glioblastoma
annotated property: has exact synonym
annotated target: Glioblastoma Multiforme
term-group: SY
term-source: NCI

Axiom
annotated source: Glioblastoma
annotated property: has exact synonym
annotated target: Glioblastoma multiforme
term-group: PT
term-source: CTEP
source-code: 10018337
subsource-name: SDC

Axiom
annotated source: Glioblastoma
annotated property: has exact synonym
annotated target: Grade IV Astrocytic Neoplasm
term-group: SY
term-source: NCI

Axiom
annotated source: Glioblastoma
annotated property: has exact synonym
annotated target: Grade IV Astrocytic Tumor
term-group: SY
term-source: NCI

Axiom
annotated source: Glioblastoma
annotated property: has exact synonym
annotated target: Spongioblastoma Multiforme
term-group: SY
term-source: NCI

Axiom
annotated source: Glioblastoma
annotated property: has exact synonym
annotated target: WHO Grade IV Glioma
term-group: SY
term-source: NCI

Axiom
annotated source: Glioblastoma
annotated property: has exact synonym
annotated target: glioblastoma
term-group: PT
term-source: NCI-GLOSS
source-code: CDR0000045698

Axiom
annotated source: Glioblastoma
annotated property: has exact synonym
annotated target: glioblastoma multiforme
term-group: PT
term-source: NCI-GLOSS
source-code: CDR0000045699

Axiom
annotated source: Glioblastoma
annotated property: has exact synonym
annotated target: grade IV astrocytoma
term-group: PT
term-source: NCI-GLOSS
source-code: CDR0000044407

Granulosa Cell Tumor
type: Class
subclass of: Sex Cord-Stromal Tumor
definition: A slow-growing, malignant tumor, characterized by the presence of granulosa-like cells and Call-Exner bodies, that is almost always found in the ovary. In rare cases, it has also been found in the testicle. There are two types of granulosa cell tumors that can be distinguished under the microscope: the adult and the juvenile. The testicular juvenile granulosa cell tumors are perhaps the most common congenital testicular neoplasms.
Has_NICHD_Parent: Sex Cord-Stromal Tumor
Concept_In_Subset: NCIT C132009
Concept_In_Subset: NCIT C90259
code: C3070
Semantic_Type: Neoplastic Process
Preferred_Name: Granulosa Cell Tumor
UMLS_CUI: C0018206
Contributing_Source: NICHD
ALT_DEFINITION: A slow-growing, malignant tumor that is characterized by the presence of granulosa-like cells, and which is almost always found in the ovary. In rare cases, it has also been found in the testicle.
ALT_DEFINITION: A type of slow-growing, malignant tumor that usually affects the ovary.
Neoplastic_Status: Undetermined
Legacy_Concept_Name: Granulosa_Cell_Tumor
NICHD_Hierarchy_Term: Granulosa Cell Tumor
has exact synonym: Granulosa Cell Neoplasm
has exact synonym: Granulosa Cell Tumor
has exact synonym: granulosa cell tumor
in subset: oncotree slim

Axiom
annotated source: Granulosa Cell Tumor
annotated property: definition
annotated target: A slow-growing, malignant tumor, characterized by the presence of granulosa-like cells and Call-Exner bodies, that is almost always found in the ovary. In rare cases, it has also been found in the testicle. There are two types of granulosa cell tumors that can be distinguished under the microscope: the adult and the juvenile. The testicular juvenile granulosa cell tumors are perhaps the most common congenital testicular neoplasms.
def-source: NCI

Axiom
annotated source: Granulosa Cell Tumor
annotated property: ALT_DEFINITION
annotated target: A slow-growing, malignant tumor that is characterized by the presence of granulosa-like cells, and which is almost always found in the ovary. In rare cases, it has also been found in the testicle.
def-source: NICHD

Axiom
annotated source: Granulosa Cell Tumor
annotated property: ALT_DEFINITION
annotated target: A type of slow-growing, malignant tumor that usually affects the ovary.
def-source: NCI-GLOSS

Axiom
annotated source: Granulosa Cell Tumor
annotated property: has exact synonym
annotated target: Granulosa Cell Neoplasm
term-group: SY
term-source: NCI

Axiom
annotated source: Granulosa Cell Tumor
annotated property: has exact synonym
annotated target: Granulosa Cell Tumor
term-group: PT
term-source: NCI

Axiom
annotated source: Granulosa Cell Tumor
annotated property: has exact synonym
annotated target: Granulosa Cell Tumor
term-group: PT
term-source: NICHD

Axiom
annotated source: Granulosa Cell Tumor
annotated property: has exact synonym
annotated target: granulosa cell tumor
term-group: PT
term-source: NCI-GLOSS
source-code: CDR0000044780

Hemangioma
type: Class
definition: A benign vascular lesion characterized by the formation of capillary-sized or cavernous vascular channels.
Has_NICHD_Parent: NCIT C3262
Concept_In_Subset: NCIT C116977
Concept_In_Subset: NCIT C118464
Concept_In_Subset: NCIT C126659
Concept_In_Subset: NCIT C61410
Concept_In_Subset: NCIT C77526
Concept_In_Subset: NCIT C88025
Concept_In_Subset: NCIT C89506
Concept_In_Subset: NCIT C90259
Concept_In_Subset: NCIT C99147
code: C3085
Semantic_Type: Neoplastic Process
Display_Name: Hemangioma
Preferred_Name: Hemangioma
UMLS_CUI: C0018916
Contributing_Source: CDISC
Contributing_Source: CTRP
Contributing_Source: MedDRA
Contributing_Source: NICHD
ALT_DEFINITION: A benign vascular neoplasm characterized by the formation of capillary-sized or cavernous vascular channels.
ALT_DEFINITION: A benign, vascular neoplasm characterized by the formation of capillary-sized vascular channels.
ICD-O-3_Code: 9120/0
Neoplastic_Status: Benign
Legacy_Concept_Name: Hemangioma
NICHD_Hierarchy_Term: Hemangioma
has exact synonym: Angioma
has exact synonym: Benign Angioma
has exact synonym: Benign Hemangioma
has exact synonym: HEMANGIOMA, BENIGN
has exact synonym: Hemangioma
in subset: oncotree slim

Axiom
annotated source: Hemangioma
annotated property: definition
annotated target: A benign vascular lesion characterized by the formation of capillary-sized or cavernous vascular channels.
def-source: NCI

Axiom
annotated source: Hemangioma
annotated property: ALT_DEFINITION
annotated target: A benign vascular neoplasm characterized by the formation of capillary-sized or cavernous vascular channels.
def-source: CDISC

Axiom
annotated source: Hemangioma
annotated property: ALT_DEFINITION
annotated target: A benign, vascular neoplasm characterized by the formation of capillary-sized vascular channels.
def-source: NICHD

Axiom
annotated source: Hemangioma
annotated property: has exact synonym
annotated target: Angioma
term-group: SY
term-source: CDISC

Axiom
annotated source: Hemangioma
annotated property: has exact synonym
annotated target: Angioma
term-group: SY
term-source: NCI

Axiom
annotated source: Hemangioma
annotated property: has exact synonym
annotated target: Benign Angioma
term-group: SY
term-source: CDISC

Axiom
annotated source: Hemangioma
annotated property: has exact synonym
annotated target: Benign Angioma
term-group: SY
term-source: NCI

Axiom
annotated source: Hemangioma
annotated property: has exact synonym
annotated target: Benign Hemangioma
term-group: SY
term-source: CDISC

Axiom
annotated source: Hemangioma
annotated property: has exact synonym
annotated target: Benign Hemangioma
term-group: SY
term-source: NCI

Axiom
annotated source: Hemangioma
annotated property: has exact synonym
annotated target: HEMANGIOMA, BENIGN
term-group: PT
term-source: CDISC

Axiom
annotated source: Hemangioma
annotated property: has exact synonym
annotated target: Hemangioma
term-group: PT
term-source: NCI

Axiom
annotated source: Hemangioma
annotated property: has exact synonym
annotated target: Hemangioma
term-group: PT
term-source: NICHD

Angiosarcoma
type: Class
definition: A malignant tumor arising from the endothelial cells of the blood vessels. Microscopically, it is characterized by frequently open vascular anastomosing and branching channels. The malignant cells that line the vascular channels are spindle or epithelioid and often display hyperchromatic nuclei. Angiosarcomas most frequently occur in the skin and breast. Patients with long-standing lymphedema are at increased risk of developing angiosarcoma.
Concept_In_Subset: NCIT C126659
Concept_In_Subset: NCIT C61410
Concept_In_Subset: NCIT C77526
Concept_In_Subset: NCIT C88025
code: C3088
Semantic_Type: Neoplastic Process
Preferred_Name: Angiosarcoma
UMLS_CUI: C0018923
Contributing_Source: CDISC
ALT_DEFINITION: A malignant vascular neoplasm arising from endothelial cells.
ALT_DEFINITION: A type of cancer that begins in the cells that line blood vessels.
ICD-O-3_Code: 9120/3
Neoplastic_Status: Malignant
Legacy_Concept_Name: Angiosarcoma
has exact synonym: Angiosarcoma
has exact synonym: HEMANGIOSARCOMA, MALIGNANT
has exact synonym: Hemangiosarcoma
has exact synonym: Malignant Angioendothelioma
has exact synonym: Malignant Hemangioendothelioma
has exact synonym: angiosarcoma
has exact synonym: hemangiosarcoma
in subset: oncotree slim

Axiom
annotated source: Angiosarcoma
annotated property: definition
annotated target: A malignant tumor arising from the endothelial cells of the blood vessels. Microscopically, it is characterized by frequently open vascular anastomosing and branching channels. The malignant cells that line the vascular channels are spindle or epithelioid and often display hyperchromatic nuclei. Angiosarcomas most frequently occur in the skin and breast. Patients with long-standing lymphedema are at increased risk of developing angiosarcoma.
def-source: NCI

Axiom
annotated source: Angiosarcoma
annotated property: ALT_DEFINITION
annotated target: A malignant vascular neoplasm arising from endothelial cells.
def-source: CDISC

Axiom
annotated source: Angiosarcoma
annotated property: ALT_DEFINITION
annotated target: A type of cancer that begins in the cells that line blood vessels.
def-source: NCI-GLOSS

Axiom
annotated source: Angiosarcoma
annotated property: has exact synonym
annotated target: Angiosarcoma
term-group: PT
term-source: CTRP

Axiom
annotated source: Angiosarcoma
annotated property: has exact synonym
annotated target: Angiosarcoma
term-group: PT
term-source: NCI

Axiom
annotated source: Angiosarcoma
annotated property: has exact synonym
annotated target: HEMANGIOSARCOMA, MALIGNANT
term-group: PT
term-source: CDISC

Axiom
annotated source: Angiosarcoma
annotated property: has exact synonym
annotated target: Hemangiosarcoma
term-group: SY
term-source: CDISC

Axiom
annotated source: Angiosarcoma
annotated property: has exact synonym
annotated target: Hemangiosarcoma
term-group: SY
term-source: NCI

Axiom
annotated source: Angiosarcoma
annotated property: has exact synonym
annotated target: Malignant Angioendothelioma
term-group: SY
term-source: NCI

Axiom
annotated source: Angiosarcoma
annotated property: has exact synonym
annotated target: Malignant Hemangioendothelioma
term-group: SY
term-source: NCI

Axiom
annotated source: Angiosarcoma
annotated property: has exact synonym
annotated target: angiosarcoma
term-group: PT
term-source: NCI-GLOSS
source-code: CDR0000046532

Axiom
annotated source: Angiosarcoma
annotated property: has exact synonym
annotated target: hemangiosarcoma
term-group: PT
term-source: NCI-GLOSS
source-code: CDR0000335069

Hepatocellular Carcinoma
type: Class
definition: A malignant tumor that arises from hepatocytes. Hepatocellular carcinoma is relatively rare in the United States but very common in all African countries south of the Sahara and in Southeast Asia. Most cases are seen in patients over the age of 50 years, but this tumor can also occur in younger individuals and even in children. Hepatocellular carcinoma is more common in males than females and is associated with hepatitis B, hepatitis C, chronic alcohol abuse and cirrhosis. Serum elevation of alpha-fetoprotein occurs in a large percentage of patients with hepatocellular carcinoma. Grossly, hepatocellular carcinoma may present as a single mass, as multiple nodules, or as diffuse liver involvement. Microscopically, there is a wide range of differentiation from tumor to tumor (well differentiated to poorly differentiated tumors). Hepatocellular carcinomas quickly metastasize to regional lymph nodes and lung. The overall median survival of untreated liver cell carcinoma is about 4 months. The most effective treatment of hepatocellular carcinoma is complete resection of the tumor. Lately, an increasing number of tumors have been treated with liver transplantation.
Concept_In_Subset: NCIT C102905
Concept_In_Subset: NCIT C103066
Concept_In_Subset: NCIT C126659
Concept_In_Subset: NCIT C61410
Concept_In_Subset: NCIT C77526
Concept_In_Subset: NCIT C88025
code: C3099
Semantic_Type: Neoplastic Process
Preferred_Name: Hepatocellular Carcinoma
UMLS_CUI: C0019204
Contributing_Source: CDISC
Contributing_Source: CTEP
ALT_DEFINITION: A malignant neoplasm arising from hepatocytes.
ALT_DEFINITION: A type of adenocarcinoma and the most common type of liver tumor.
ICD-O-3_Code: 8170/3
Neoplastic_Status: Malignant
Legacy_Concept_Name: Hepatocellular_Carcinoma
has exact synonym: CARCINOMA, HEPATOCELLULAR, MALIGNANT
has exact synonym: Carcinoma of Liver Cells
has exact synonym: Carcinoma of the Liver Cells
has exact synonym: HCC
has exact synonym: Hepatocellular Cancer
has exact synonym: Hepatocellular Carcinoma
has exact synonym: Hepatocellular carcinoma
has exact synonym: Hepatoma
has exact synonym: Liver Cell Cancer (Hepatocellular Carcinoma)
has exact synonym: Liver Cell Carcinoma
has exact synonym: Primary Carcinoma of Liver Cells
has exact synonym: Primary Carcinoma of the Liver Cells
has exact synonym: hepatocellular carcinoma
has exact synonym: hepatoma
in subset: oncotree slim

Axiom
annotated source: Hepatocellular Carcinoma
annotated property: definition
annotated target: A malignant tumor that arises from hepatocytes. Hepatocellular carcinoma is relatively rare in the United States but very common in all African countries south of the Sahara and in Southeast Asia. Most cases are seen in patients over the age of 50 years, but this tumor can also occur in younger individuals and even in children. Hepatocellular carcinoma is more common in males than females and is associated with hepatitis B, hepatitis C, chronic alcohol abuse and cirrhosis. Serum elevation of alpha-fetoprotein occurs in a large percentage of patients with hepatocellular carcinoma. Grossly, hepatocellular carcinoma may present as a single mass, as multiple nodules, or as diffuse liver involvement. Microscopically, there is a wide range of differentiation from tumor to tumor (well differentiated to poorly differentiated tumors). Hepatocellular carcinomas quickly metastasize to regional lymph nodes and lung. The overall median survival of untreated liver cell carcinoma is about 4 months. The most effective treatment of hepatocellular carcinoma is complete resection of the tumor. Lately, an increasing number of tumors have been treated with liver transplantation.
def-source: NCI

Axiom
annotated source: Hepatocellular Carcinoma
annotated property: ALT_DEFINITION
annotated target: A malignant neoplasm arising from hepatocytes.
def-source: CDISC

Axiom
annotated source: Hepatocellular Carcinoma
annotated property: ALT_DEFINITION
annotated target: A type of adenocarcinoma and the most common type of liver tumor.
def-source: NCI-GLOSS

Axiom
annotated source: Hepatocellular Carcinoma
annotated property: has exact synonym
annotated target: CARCINOMA, HEPATOCELLULAR, MALIGNANT
term-group: PT
term-source: CDISC

Axiom
annotated source: Hepatocellular Carcinoma
annotated property: has exact synonym
annotated target: Carcinoma of Liver Cells
term-group: SY
term-source: CDISC

Axiom
annotated source: Hepatocellular Carcinoma
annotated property: has exact synonym
annotated target: Carcinoma of Liver Cells
term-group: SY
term-source: NCI

Axiom
annotated source: Hepatocellular Carcinoma
annotated property: has exact synonym
annotated target: Carcinoma of the Liver Cells
term-group: SY
term-source: CDISC

Axiom
annotated source: Hepatocellular Carcinoma
annotated property: has exact synonym
annotated target: Carcinoma of the Liver Cells
term-group: SY
term-source: NCI

Axiom
annotated source: Hepatocellular Carcinoma
annotated property: has exact synonym
annotated target: HCC
term-group: AB
term-source: NCI

Axiom
annotated source: Hepatocellular Carcinoma
annotated property: has exact synonym
annotated target: HCC
term-group: SY
term-source: CDISC

Axiom
annotated source: Hepatocellular Carcinoma
annotated property: has exact synonym
annotated target: Hepatocellular Cancer
term-group: DN
term-source: CTRP

Axiom
annotated source: Hepatocellular Carcinoma
annotated property: has exact synonym
annotated target: Hepatocellular Carcinoma
term-group: PT
term-source: CTRP

Axiom
annotated source: Hepatocellular Carcinoma
annotated property: has exact synonym
annotated target: Hepatocellular Carcinoma
term-group: PT
term-source: NCI

Axiom
annotated source: Hepatocellular Carcinoma
annotated property: has exact synonym
annotated target: Hepatocellular Carcinoma
term-group: SY
term-source: NCI
source-code: TCGA
subsource-name: caDSR

Axiom
annotated source: Hepatocellular Carcinoma
annotated property: has exact synonym
annotated target: Hepatocellular carcinoma
term-group: PT
term-source: CTEP
source-code: 10049010
subsource-name: SDC

Axiom
annotated source: Hepatocellular Carcinoma
annotated property: has exact synonym
annotated target: Hepatoma
term-group: SY
term-source: CDISC

Axiom
annotated source: Hepatocellular Carcinoma
annotated property: has exact synonym
annotated target: Hepatoma
term-group: SY
term-source: NCI

Axiom
annotated source: Hepatocellular Carcinoma
annotated property: has exact synonym
annotated target: Liver Cell Cancer (Hepatocellular Carcinoma)
term-group: SY
term-source: NCI

Axiom
annotated source: Hepatocellular Carcinoma
annotated property: has exact synonym
annotated target: Liver Cell Carcinoma
term-group: SY
term-source: CDISC

Axiom
annotated source: Hepatocellular Carcinoma
annotated property: has exact synonym
annotated target: Liver Cell Carcinoma
term-group: SY
term-source: NCI

Axiom
annotated source: Hepatocellular Carcinoma
annotated property: has exact synonym
annotated target: Primary Carcinoma of Liver Cells
term-group: SY
term-source: CDISC

Axiom
annotated source: Hepatocellular Carcinoma
annotated property: has exact synonym
annotated target: Primary Carcinoma of Liver Cells
term-group: SY
term-source: NCI

Axiom
annotated source: Hepatocellular Carcinoma
annotated property: has exact synonym
annotated target: Primary Carcinoma of the Liver Cells
term-group: SY
term-source: CDISC

Axiom
annotated source: Hepatocellular Carcinoma
annotated property: has exact synonym
annotated target: Primary Carcinoma of the Liver Cells
term-group: SY
term-source: NCI

Axiom
annotated source: Hepatocellular Carcinoma
annotated property: has exact synonym
annotated target: hepatocellular carcinoma
term-group: PT
term-source: NCI-GLOSS
source-code: CDR0000046363

Axiom
annotated source: Hepatocellular Carcinoma
annotated property: has exact synonym
annotated target: hepatoma
term-group: PT
term-source: NCI-GLOSS
source-code: CDR0000046661

Histiocytosis
type: Class
definition: A morphologic finding indicating tissue infiltration by non-neoplastic or neoplastic histiocytes.
Has_NICHD_Parent: NCIT C3262
Concept_In_Subset: NCIT C90259
Concept_In_Subset: NCIT C99147
code: C3106
Semantic_Type: Finding
Preferred_Name: Histiocytosis
UMLS_CUI: C0019618
Contributing_Source: NICHD
Legacy_Concept_Name: Histiocytosis
NICHD_Hierarchy_Term: Histiocytosis
has exact synonym: Histiocytic Infiltrate
has exact synonym: Histiocytic Syndrome
has exact synonym: Histiocytosis
in subset: oncotree slim

Axiom
annotated source: Histiocytosis
annotated property: definition
annotated target: A morphologic finding indicating tissue infiltration by non-neoplastic or neoplastic histiocytes.
def-source: NCI

Axiom
annotated source: Histiocytosis
annotated property: has exact synonym
annotated target: Histiocytic Infiltrate
term-group: SY
term-source: NCI
source-code: TCGA
subsource-name: caDSR

Axiom
annotated source: Histiocytosis
annotated property: has exact synonym
annotated target: Histiocytic Syndrome
term-group: SY
term-source: NICHD

Axiom
annotated source: Histiocytosis
annotated property: has exact synonym
annotated target: Histiocytosis
term-group: PT
term-source: NCI

Axiom
annotated source: Histiocytosis
annotated property: has exact synonym
annotated target: Histiocytosis
term-group: PT
term-source: NICHD

Langerhans Cell Histiocytosis
type: Class
subclass of: NCIT C9294
definition: A neoplastic proliferation of Langerhans cells which contain Birbeck granules by ultrastructural examination. Three major overlapping syndromes are recognized: eosinophilic granuloma, Letterer-Siwe disease, and Hand-Schuller-Christian disease. The clinical course is generally related to the number of organs affected at presentation. (WHO, 2001)
Has_NICHD_Parent: NCIT C26323
Concept_In_Subset: NCIT C102905
Concept_In_Subset: NCIT C103078
Concept_In_Subset: NCIT C116977
Concept_In_Subset: NCIT C118467
Concept_In_Subset: NCIT C126659
Concept_In_Subset: NCIT C90259
code: C3107
Semantic_Type: Neoplastic Process
Display_Name: Langerhans Cell Histiocytosis
Preferred_Name: Langerhans Cell Histiocytosis
UMLS_CUI: C0019621
Contributing_Source: CTEP
Contributing_Source: CTRP
Contributing_Source: NICHD
ALT_DEFINITION: A group of rare disorders in which too many Langerhans cells (a type of white blood cell) grow in certain tissues and organs including the bones, skin, and lungs, and damage them. Langerhans cell histiocytosis may also affect the pituitary gland (which makes hormones that control other glands and many body functions, especially growth). Langerhans cell histiocytosis is most common in children and young adults.
ALT_DEFINITION: Tissue infiltration by Langerhans cells (histiocytes). When infiltration involves the pituitary stalk or gland, presentation includes diabetes insipidus, which is sometimes accompanied by other pituitary dysfunction.
ICD-O-3_Code: 9751/1
ICD-O-3_Code: 9751/3
ICD-O-3_Code: 9752/1
ICD-O-3_Code: 9753/1
ICD-O-3_Code: 9754/3
Neoplastic_Status: Undetermined
Legacy_Concept_Name: Langerhans_Cell_Histiocytosis
NICHD_Hierarchy_Term: Langerhans Cell Histiocytosis
has exact synonym: Histiocytosis X
has exact synonym: LCH
has exact synonym: Langerhans Cell Granulomatosis
has exact synonym: Langerhans Cell Histiocytosis
has exact synonym: Langerhans cell histiocytosis
in subset: oncotree slim

Axiom
annotated source: Langerhans Cell Histiocytosis
annotated property: definition
annotated target: A neoplastic proliferation of Langerhans cells which contain Birbeck granules by ultrastructural examination. Three major overlapping syndromes are recognized: eosinophilic granuloma, Letterer-Siwe disease, and Hand-Schuller-Christian disease. The clinical course is generally related to the number of organs affected at presentation. (WHO, 2001)
def-source: NCI

Axiom
annotated source: Langerhans Cell Histiocytosis
annotated property: ALT_DEFINITION
annotated target: A group of rare disorders in which too many Langerhans cells (a type of white blood cell) grow in certain tissues and organs including the bones, skin, and lungs, and damage them. Langerhans cell histiocytosis may also affect the pituitary gland (which makes hormones that control other glands and many body functions, especially growth). Langerhans cell histiocytosis is most common in children and young adults.
def-source: NCI-GLOSS

Axiom
annotated source: Langerhans Cell Histiocytosis
annotated property: ALT_DEFINITION
annotated target: Tissue infiltration by Langerhans cells (histiocytes). When infiltration involves the pituitary stalk or gland, presentation includes diabetes insipidus, which is sometimes accompanied by other pituitary dysfunction.
def-source: NICHD

Axiom
annotated source: Langerhans Cell Histiocytosis
annotated property: has exact synonym
annotated target: Histiocytosis X
term-group: AQS
term-source: NICHD

Axiom
annotated source: Langerhans Cell Histiocytosis
annotated property: has exact synonym
annotated target: Histiocytosis X
term-group: SY
term-source: NCI

Axiom
annotated source: Langerhans Cell Histiocytosis
annotated property: has exact synonym
annotated target: LCH
term-group: AB
term-source: NCI

Axiom
annotated source: Langerhans Cell Histiocytosis
annotated property: has exact synonym
annotated target: LCH
term-group: PT
term-source: NCI-GLOSS
source-code: CDR0000513054

Axiom
annotated source: Langerhans Cell Histiocytosis
annotated property: has exact synonym
annotated target: Langerhans Cell Granulomatosis
term-group: SY
term-source: NCI

Axiom
annotated source: Langerhans Cell Histiocytosis
annotated property: has exact synonym
annotated target: Langerhans Cell Histiocytosis
term-group: PT
term-source: NCI

Axiom
annotated source: Langerhans Cell Histiocytosis
annotated property: has exact synonym
annotated target: Langerhans Cell Histiocytosis
term-group: PT
term-source: NICHD

Axiom
annotated source: Langerhans Cell Histiocytosis
annotated property: has exact synonym
annotated target: Langerhans Cell Histiocytosis
term-group: SY
term-source: NCI
source-code: TCGA
subsource-name: caDSR

Axiom
annotated source: Langerhans Cell Histiocytosis
annotated property: has exact synonym
annotated target: Langerhans cell histiocytosis
term-group: PT
term-source: CTEP
source-code: 10025581
subsource-name: SDC

Axiom
annotated source: Langerhans Cell Histiocytosis
annotated property: has exact synonym
annotated target: Langerhans cell histiocytosis
term-group: PT
term-source: NCI-GLOSS
source-code: CDR0000471787

Hydatidiform Mole
type: Class
definition: A gestational trophoblastic disorder characterized by marked enlargement of the chorionic villi, hyperplasia of the villous trophoblastic cells and hydropic changes.
Has_NICHD_Parent: NCIT C117337
Concept_In_Subset: NCIT C116977
Concept_In_Subset: NCIT C118466
Concept_In_Subset: NCIT C90259
code: C3110
Semantic_Type: Disease or Syndrome
Display_Name: Hydatidiform Mole
Preferred_Name: Hydatidiform Mole
UMLS_CUI: C0020217
Contributing_Source: CTRP
Contributing_Source: NICHD
ALT_DEFINITION: A placental disorder characterized by abnormal development with marked enlargement of the chorionic villi and hydropic changes which consist of hyperplasia of the villous trophoblastic cells.
ALT_DEFINITION: A slow-growing tumor that develops from trophoblastic cells (cells that help an embryo attach to the uterus and help form the placenta) after fertilization of an egg by a sperm. A hydatidiform mole contains many cysts (sacs of fluid). It is usually benign (not cancer) but it may spread to nearby tissues (invasive mole). It may also become a malignant tumor called choriocarcinoma. Hydatidiform mole is the most common type of gestational trophoblastic tumor.
ICD-O-3_Code: 9100/0
Legacy_Concept_Name: Hydatidiform_Mole
NICHD_Hierarchy_Term: Hydatidiform Mole
has exact synonym: Hydatid Mole
has exact synonym: Hydatidiform Mole
has exact synonym: Molar Pregnancy
has exact synonym: hydatidiform mole
has exact synonym: molar pregnancy
in subset: oncotree slim

Axiom
annotated source: Hydatidiform Mole
annotated property: definition
annotated target: A gestational trophoblastic disorder characterized by marked enlargement of the chorionic villi, hyperplasia of the villous trophoblastic cells and hydropic changes.
def-source: NCI

Axiom
annotated source: Hydatidiform Mole
annotated property: ALT_DEFINITION
annotated target: A placental disorder characterized by abnormal development with marked enlargement of the chorionic villi and hydropic changes which consist of hyperplasia of the villous trophoblastic cells.
def-source: NICHD

Axiom
annotated source: Hydatidiform Mole
annotated property: ALT_DEFINITION
annotated target: A slow-growing tumor that develops from trophoblastic cells (cells that help an embryo attach to the uterus and help form the placenta) after fertilization of an egg by a sperm. A hydatidiform mole contains many cysts (sacs of fluid). It is usually benign (not cancer) but it may spread to nearby tissues (invasive mole). It may also become a malignant tumor called choriocarcinoma. Hydatidiform mole is the most common type of gestational trophoblastic tumor.
def-source: NCI-GLOSS

Axiom
annotated source: Hydatidiform Mole
annotated property: has exact synonym
annotated target: Hydatid Mole
term-group: SY
term-source: NCI

Axiom
annotated source: Hydatidiform Mole
annotated property: has exact synonym
annotated target: Hydatidiform Mole
term-group: PT
term-source: NCI

Axiom
annotated source: Hydatidiform Mole
annotated property: has exact synonym
annotated target: Hydatidiform Mole
term-group: PT
term-source: NICHD

Axiom
annotated source: Hydatidiform Mole
annotated property: has exact synonym
annotated target: Molar Pregnancy
term-group: SY
term-source: NCI

Axiom
annotated source: Hydatidiform Mole
annotated property: has exact synonym
annotated target: hydatidiform mole
term-group: PT
term-source: NCI-GLOSS
source-code: CDR0000446933

Axiom
annotated source: Hydatidiform Mole
annotated property: has exact synonym
annotated target: molar pregnancy
term-group: PT
term-source: NCI-GLOSS
source-code: CDR0000046747

Leiomyosarcoma
type: Class
definition: An uncommon, aggressive malignant smooth muscle neoplasm, usually occurring in post-menopausal women. It is characterized by a proliferation of neoplastic spindle cells. Morphologic variants include epithelioid, granular cell, inflammatory and myxoid leimyosarcomas.
Concept_In_Subset: NCIT C102905
Concept_In_Subset: NCIT C103117
Concept_In_Subset: NCIT C126659
Concept_In_Subset: NCIT C61410
Concept_In_Subset: NCIT C77526
Concept_In_Subset: NCIT C88025
code: C3158
Semantic_Type: Neoplastic Process
Preferred_Name: Leiomyosarcoma
UMLS_CUI: C0023269
Contributing_Source: CDISC
Contributing_Source: CTEP
ALT_DEFINITION: A malignant (cancer) tumor of smooth muscle cells that can arise almost anywhere in the body, but is most common in the uterus, abdomen, or pelvis.
ALT_DEFINITION: A malignant neoplasm, originating from smooth muscle cells.
ICD-O-3_Code: 8890/3
Neoplastic_Status: Malignant
Legacy_Concept_Name: Leiomyosarcoma
has exact synonym: LEIOMYOSARCOMA, MALIGNANT
has exact synonym: Leiomyosarcoma
has exact synonym: Leiomyosarcoma (excluding uterine leiomyosarcoma)
has exact synonym: Leiomyosarcoma - not uterine
has exact synonym: Leiomyosarcomas
has exact synonym: leiomyosarcoma
in subset: oncotree slim

Axiom
annotated source: Leiomyosarcoma
annotated property: definition
annotated target: An uncommon, aggressive malignant smooth muscle neoplasm, usually occurring in post-menopausal women. It is characterized by a proliferation of neoplastic spindle cells. Morphologic variants include epithelioid, granular cell, inflammatory and myxoid leimyosarcomas.
def-source: NCI

Axiom
annotated source: Leiomyosarcoma
annotated property: ALT_DEFINITION
annotated target: A malignant (cancer) tumor of smooth muscle cells that can arise almost anywhere in the body, but is most common in the uterus, abdomen, or pelvis.
def-source: NCI-GLOSS

Axiom
annotated source: Leiomyosarcoma
annotated property: ALT_DEFINITION
annotated target: A malignant neoplasm, originating from smooth muscle cells.
def-source: CDISC

Axiom
annotated source: Leiomyosarcoma
annotated property: has exact synonym
annotated target: LEIOMYOSARCOMA, MALIGNANT
term-group: PT
term-source: CDISC

Axiom
annotated source: Leiomyosarcoma
annotated property: has exact synonym
annotated target: Leiomyosarcoma
term-group: PT
term-source: CTRP

Axiom
annotated source: Leiomyosarcoma
annotated property: has exact synonym
annotated target: Leiomyosarcoma
term-group: PT
term-source: NCI

Axiom
annotated source: Leiomyosarcoma
annotated property: has exact synonym
annotated target: Leiomyosarcoma
term-group: SY
term-source: NCI
source-code: TCGA
subsource-name: caDSR

Axiom
annotated source: Leiomyosarcoma
annotated property: has exact synonym
annotated target: Leiomyosarcoma (excluding uterine leiomyosarcoma)
term-group: PT
term-source: CTEP
source-code: 10024193
subsource-name: SDC

Axiom
annotated source: Leiomyosarcoma
annotated property: has exact synonym
annotated target: Leiomyosarcoma - not uterine
term-group: SY
term-source: CTEP
source-code: 10024193
subsource-name: SDC

Axiom
annotated source: Leiomyosarcoma
annotated property: has exact synonym
annotated target: Leiomyosarcomas
term-group: SY
term-source: CDISC

Axiom
annotated source: Leiomyosarcoma
annotated property: has exact synonym
annotated target: leiomyosarcoma
term-group: PT
term-source: NCI-GLOSS
source-code: CDR0000046027

Leukemia
type: Class
definition: A malignant (clonal) hematologic disorder, involving hematopoietic stem cells and characterized by the presence of primitive or atypical myeloid or lymphoid cells in the bone marrow and the blood. Leukemias are classified as acute or chronic based on the degree of cellular differentiation and the predominant cell type present. Leukemia is usually associated with anemia, fever, hemorrhagic episodes, and splenomegaly. Common leukemias include acute myeloid leukemia, chronic myelogenous leukemia, acute lymphoblastic or precursor lymphoblastic leukemia, and chronic lymphocytic leukemia. Treatment is vital to patient survival; untreated, the natural course of acute leukemias is normally measured in weeks or months, while that of chronic leukemias is more often measured in months or years.
Has_NICHD_Parent: NCIT C9305
Concept_In_Subset: NCIT C102905
Concept_In_Subset: NCIT C103127
Concept_In_Subset: NCIT C116977
Concept_In_Subset: NCIT C118464
Concept_In_Subset: NCIT C126659
Concept_In_Subset: NCIT C61410
Concept_In_Subset: NCIT C77526
Concept_In_Subset: NCIT C88025
Concept_In_Subset: NCIT C90259
Concept_In_Subset: NCIT C99147
code: C3161
Semantic_Type: Neoplastic Process
Display_Name: Leukemia
Preferred_Name: Leukemia
UMLS_CUI: C0023418
Contributing_Source: CDISC
Contributing_Source: CTEP
Contributing_Source: CTRP
Contributing_Source: MedDRA
Contributing_Source: NICHD
ALT_DEFINITION: A cancer of the blood or bone marrow that is characterized by increased production of abnormal blood cells.
ALT_DEFINITION: A progressive, proliferative disease of blood cells, originating from myeloid or lymphoid stem cells.
ALT_DEFINITION: Cancer that starts in blood-forming tissue such as the bone marrow and causes large numbers of blood cells to be produced and enter the bloodstream.
ICD-O-3_Code: 9800/3
Neoplastic_Status: Malignant
Legacy_Concept_Name: Leukemia
NICHD_Hierarchy_Term: Leukemia
has exact synonym: Blood (Leukemia)
has exact synonym: LEUKEMIA, MALIGNANT
has exact synonym: Leukemia
has exact synonym: Leukemia NOS
has exact synonym: Leukemia, Disease
has exact synonym: Leukemia, NOS
has exact synonym: Leukemias
has exact synonym: Leukemias, General
has exact synonym: leukemia
in subset: oncotree slim

Axiom
annotated source: Leukemia
annotated property: definition
annotated target: A malignant (clonal) hematologic disorder, involving hematopoietic stem cells and characterized by the presence of primitive or atypical myeloid or lymphoid cells in the bone marrow and the blood. Leukemias are classified as acute or chronic based on the degree of cellular differentiation and the predominant cell type present. Leukemia is usually associated with anemia, fever, hemorrhagic episodes, and splenomegaly. Common leukemias include acute myeloid leukemia, chronic myelogenous leukemia, acute lymphoblastic or precursor lymphoblastic leukemia, and chronic lymphocytic leukemia. Treatment is vital to patient survival; untreated, the natural course of acute leukemias is normally measured in weeks or months, while that of chronic leukemias is more often measured in months or years.
def-source: NCI

Axiom
annotated source: Leukemia
annotated property: ALT_DEFINITION
annotated target: A cancer of the blood or bone marrow that is characterized by increased production of abnormal blood cells.
def-source: NICHD

Axiom
annotated source: Leukemia
annotated property: ALT_DEFINITION
annotated target: A progressive, proliferative disease of blood cells, originating from myeloid or lymphoid stem cells.
def-source: CDISC

Axiom
annotated source: Leukemia
annotated property: ALT_DEFINITION
annotated target: Cancer that starts in blood-forming tissue such as the bone marrow and causes large numbers of blood cells to be produced and enter the bloodstream.
def-source: NCI-GLOSS

Axiom
annotated source: Leukemia
annotated property: has exact synonym
annotated target: Blood (Leukemia)
term-group: SY
term-source: CDISC

Axiom
annotated source: Leukemia
annotated property: has exact synonym
annotated target: Blood (Leukemia)
term-group: SY
term-source: NCI

Axiom
annotated source: Leukemia
annotated property: has exact synonym
annotated target: LEUKEMIA, MALIGNANT
term-group: PT
term-source: CDISC

Axiom
annotated source: Leukemia
annotated property: has exact synonym
annotated target: Leukemia
term-group: DN
term-source: CTRP

Axiom
annotated source: Leukemia
annotated property: has exact synonym
annotated target: Leukemia
term-group: PT
term-source: CTRP

Axiom
annotated source: Leukemia
annotated property: has exact synonym
annotated target: Leukemia
term-group: PT
term-source: NCI

Axiom
annotated source: Leukemia
annotated property: has exact synonym
annotated target: Leukemia
term-group: PT
term-source: NICHD

Axiom
annotated source: Leukemia
annotated property: has exact synonym
annotated target: Leukemia
term-group: SY
term-source: NCI
source-code: TCGA
subsource-name: caDSR

Axiom
annotated source: Leukemia
annotated property: has exact synonym
annotated target: Leukemia NOS
term-group: SY
term-source: CDISC

Axiom
annotated source: Leukemia
annotated property: has exact synonym
annotated target: Leukemia, Disease
term-group: SY
term-source: NICHD

Axiom
annotated source: Leukemia
annotated property: has exact synonym
annotated target: Leukemia, NOS
term-group: PT
term-source: CTEP
source-code: 10024312
subsource-name: SDC

Axiom
annotated source: Leukemia
annotated property: has exact synonym
annotated target: Leukemias
term-group: SY
term-source: CDISC

Axiom
annotated source: Leukemia
annotated property: has exact synonym
annotated target: Leukemias, General
term-group: SY
term-source: CDISC

Axiom
annotated source: Leukemia
annotated property: has exact synonym
annotated target: leukemia
term-group: PT
term-source: NCI-GLOSS
source-code: CDR0000045343

Chronic Lymphocytic Leukemia
type: Class
definition: The most common type of chronic lymphoid leukemia. It comprises 90% of chronic lymphoid leukemias in the United States. Morphologically, the neoplastic cells are small, round B-lymphocytes. This type of leukemia is not considered to be curable with available therapy. (WHO, 2001)
Concept_In_Subset: NCIT C102905
Concept_In_Subset: NCIT C103125
Concept_In_Subset: NCIT C116977
Concept_In_Subset: NCIT C126659
code: C3163
Semantic_Type: Neoplastic Process
Display_Name: Chronic Lymphocytic Leukemia (CLL)
Preferred_Name: Chronic Lymphocytic Leukemia
UMLS_CUI: C0023434
Contributing_Source: CTEP
Contributing_Source: CTRP
ALT_DEFINITION: An indolent (slow-growing) cancer in which too many immature lymphocytes (white blood cells) are found mostly in the blood and bone marrow. Sometimes, in later stages of the disease, cancer cells are found in the lymph nodes and the disease is called small lymphocytic lymphoma.
Neoplastic_Status: Malignant
Legacy_Concept_Name: Chronic_Lymphocytic_Leukemia
has exact synonym: B Cell CLL
has exact synonym: B Cell Chronic Lymphocytic Leukemia
has exact synonym: B Cell Lymphocytic Leukemia
has exact synonym: B-Cell CLL
has exact synonym: B-Cell Chronic Lymphocytic Leukemia
has exact synonym: B-Cell Chronic Lymphogenous Leukemia
has exact synonym: B-Cell Chronic Lymphoid Leukemia
has exact synonym: B-Cell Lymphocytic Leukemia
has exact synonym: BCLL
has exact synonym: CLL
has exact synonym: Chronic B-Cell Lymphocytic Leukemia
has exact synonym: Chronic Lymphatic Leukemia
has exact synonym: Chronic Lymphocytic Leukemia
has exact synonym: Chronic Lymphocytic Leukemia (CLL)
has exact synonym: Chronic Lymphogenous Leukemia
has exact synonym: Chronic lymphocytic leukemia, NOS
has exact synonym: Hematopoeitic - Chronic Lymphocytic Leukemia (CLL)
has exact synonym: chronic lymphocytic leukemia
in subset: oncotree slim

Axiom
annotated source: Chronic Lymphocytic Leukemia
annotated property: definition
annotated target: The most common type of chronic lymphoid leukemia. It comprises 90% of chronic lymphoid leukemias in the United States. Morphologically, the neoplastic cells are small, round B-lymphocytes. This type of leukemia is not considered to be curable with available therapy. (WHO, 2001)
def-source: NCI

Axiom
annotated source: Chronic Lymphocytic Leukemia
annotated property: ALT_DEFINITION
annotated target: An indolent (slow-growing) cancer in which too many immature lymphocytes (white blood cells) are found mostly in the blood and bone marrow. Sometimes, in later stages of the disease, cancer cells are found in the lymph nodes and the disease is called small lymphocytic lymphoma.
def-source: NCI-GLOSS

Axiom
annotated source: Chronic Lymphocytic Leukemia
annotated property: has exact synonym
annotated target: B Cell CLL
term-group: SY
term-source: NCI

Axiom
annotated source: Chronic Lymphocytic Leukemia
annotated property: has exact synonym
annotated target: B Cell Chronic Lymphocytic Leukemia
term-group: SY
term-source: NCI

Axiom
annotated source: Chronic Lymphocytic Leukemia
annotated property: has exact synonym
annotated target: B Cell Lymphocytic Leukemia
term-group: SY
term-source: NCI

Axiom
annotated source: Chronic Lymphocytic Leukemia
annotated property: has exact synonym
annotated target: B-Cell CLL
term-group: SY
term-source: NCI

Axiom
annotated source: Chronic Lymphocytic Leukemia
annotated property: has exact synonym
annotated target: B-Cell Chronic Lymphocytic Leukemia
term-group: SY
term-source: NCI

Axiom
annotated source: Chronic Lymphocytic Leukemia
annotated property: has exact synonym
annotated target: B-Cell Chronic Lymphogenous Leukemia
term-group: SY
term-source: NCI

Axiom
annotated source: Chronic Lymphocytic Leukemia
annotated property: has exact synonym
annotated target: B-Cell Chronic Lymphoid Leukemia
term-group: SY
term-source: NCI

Axiom
annotated source: Chronic Lymphocytic Leukemia
annotated property: has exact synonym
annotated target: B-Cell Lymphocytic Leukemia
term-group: SY
term-source: NCI

Axiom
annotated source: Chronic Lymphocytic Leukemia
annotated property: has exact synonym
annotated target: BCLL
term-group: AB
term-source: NCI

Axiom
annotated source: Chronic Lymphocytic Leukemia
annotated property: has exact synonym
annotated target: CLL
term-group: AB
term-source: NCI

Axiom
annotated source: Chronic Lymphocytic Leukemia
annotated property: has exact synonym
annotated target: CLL
term-group: PT
term-source: NCI-GLOSS
source-code: CDR0000346545

Axiom
annotated source: Chronic Lymphocytic Leukemia
annotated property: has exact synonym
annotated target: Chronic B-Cell Lymphocytic Leukemia
term-group: SY
term-source: NCI

Axiom
annotated source: Chronic Lymphocytic Leukemia
annotated property: has exact synonym
annotated target: Chronic Lymphatic Leukemia
term-group: SY
term-source: NCI

Axiom
annotated source: Chronic Lymphocytic Leukemia
annotated property: has exact synonym
annotated target: Chronic Lymphocytic Leukemia
term-group: PT
term-source: NCI

Axiom
annotated source: Chronic Lymphocytic Leukemia
annotated property: has exact synonym
annotated target: Chronic Lymphocytic Leukemia
term-group: SY
term-source: CTRP

Axiom
annotated source: Chronic Lymphocytic Leukemia
annotated property: has exact synonym
annotated target: Chronic Lymphocytic Leukemia (CLL)
term-group: DN
term-source: CTRP

Axiom
annotated source: Chronic Lymphocytic Leukemia
annotated property: has exact synonym
annotated target: Chronic Lymphocytic Leukemia (CLL)
term-group: PT
term-source: CTRP

Axiom
annotated source: Chronic Lymphocytic Leukemia
annotated property: has exact synonym
annotated target: Chronic Lymphogenous Leukemia
term-group: SY
term-source: NCI

Axiom
annotated source: Chronic Lymphocytic Leukemia
annotated property: has exact synonym
annotated target: Chronic lymphocytic leukemia, NOS
term-group: PT
term-source: CTEP
source-code: 10008960
subsource-name: SDC

Axiom
annotated source: Chronic Lymphocytic Leukemia
annotated property: has exact synonym
annotated target: Hematopoeitic - Chronic Lymphocytic Leukemia (CLL)
term-group: SY
term-source: NCI

Axiom
annotated source: Chronic Lymphocytic Leukemia
annotated property: has exact synonym
annotated target: chronic lymphocytic leukemia
term-group: PT
term-source: NCI-GLOSS
source-code: CDR0000044846

Acute Lymphoblastic Leukemia
type: Class
definition: Leukemia with an acute onset, characterized by the presence of lymphoblasts in the bone marrow and the peripheral blood. It includes the acute B lymphoblastic leukemia and acute T lymphoblastic leukemia.
Has_NICHD_Parent: Leukemia
Concept_In_Subset: NCIT C102905
Concept_In_Subset: NCIT C103123
Concept_In_Subset: NCIT C116977
Concept_In_Subset: NCIT C118464
Concept_In_Subset: NCIT C126659
Concept_In_Subset: NCIT C61410
Concept_In_Subset: NCIT C77526
Concept_In_Subset: NCIT C88025
Concept_In_Subset: NCIT C90259
code: C3167
Semantic_Type: Neoplastic Process
Display_Name: Acute Lymphoblastic Leukemia (ALL)
Preferred_Name: Acute Lymphoblastic Leukemia
UMLS_CUI: C0023449
Contributing_Source: CDISC
Contributing_Source: CTEP
Contributing_Source: CTRP
Contributing_Source: MedDRA
Contributing_Source: NICHD
ALT_DEFINITION: A progressive, proliferative disease of blood cells, originating from immature lymphoid cells.
ALT_DEFINITION: A rapidly progressive cancer of the blood and bone marrow consisting of the proliferation of lymphoblasts, which are immature, dysfunctional white blood cells.
ALT_DEFINITION: An aggressive (fast-growing) type of leukemia (blood cancer) in which too many lymphoblasts (immature white blood cells) are found in the blood and bone marrow.
ICD-O-3_Code: 9835/3
Neoplastic_Status: Malignant
Legacy_Concept_Name: Acute_Lymphoblastic_Leukemia
NICHD_Hierarchy_Term: Acute Lymphoblastic Leukemia
has exact synonym: ALL
has exact synonym: ALL - Acute Lymphocytic Leukemia
has exact synonym: Acute Lymphoblastic Leukemia
has exact synonym: Acute Lymphoblastic Leukemia (ALL)
has exact synonym: Acute Lymphocytic Leukaemia
has exact synonym: Acute Lymphocytic Leukemia
has exact synonym: Acute Lymphocytic Leukemias
has exact synonym: Acute Lymphogenous Leukemia
has exact synonym: Acute Lymphoid Leukemia
has exact synonym: Acute lymphoblastic leukemia
has exact synonym: Acute lymphoblastic leukemia, NOS
has exact synonym: LEUKEMIA, LYMPHOBLASTIC, MALIGNANT
has exact synonym: Lymphoblastic Leukemia
has exact synonym: Precursor Cell Lymphoblastic Leukemia
has exact synonym: Precursor Lymphoblasic Leukemia
has exact synonym: Precursor Lymphoblastic Leukemia
has exact synonym: acute lymphoblastic leukemia
has exact synonym: acute lymphocytic leukemia
in subset: oncotree slim

Axiom
annotated source: Acute Lymphoblastic Leukemia
annotated property: definition
annotated target: Leukemia with an acute onset, characterized by the presence of lymphoblasts in the bone marrow and the peripheral blood. It includes the acute B lymphoblastic leukemia and acute T lymphoblastic leukemia.
def-source: NCI

Axiom
annotated source: Acute Lymphoblastic Leukemia
annotated property: ALT_DEFINITION
annotated target: A progressive, proliferative disease of blood cells, originating from immature lymphoid cells.
def-source: CDISC

Axiom
annotated source: Acute Lymphoblastic Leukemia
annotated property: ALT_DEFINITION
annotated target: A rapidly progressive cancer of the blood and bone marrow consisting of the proliferation of lymphoblasts, which are immature, dysfunctional white blood cells.
def-source: NICHD

Axiom
annotated source: Acute Lymphoblastic Leukemia
annotated property: ALT_DEFINITION
annotated target: An aggressive (fast-growing) type of leukemia (blood cancer) in which too many lymphoblasts (immature white blood cells) are found in the blood and bone marrow.
def-source: NCI-GLOSS

Axiom
annotated source: Acute Lymphoblastic Leukemia
annotated property: has exact synonym
annotated target: ALL
term-group: AB
term-source: NCI

Axiom
annotated source: Acute Lymphoblastic Leukemia
annotated property: has exact synonym
annotated target: ALL
term-group: PT
term-source: NCI-GLOSS
source-code: CDR0000044362

Axiom
annotated source: Acute Lymphoblastic Leukemia
annotated property: has exact synonym
annotated target: ALL
term-group: SY
term-source: CDISC

Axiom
annotated source: Acute Lymphoblastic Leukemia
annotated property: has exact synonym
annotated target: ALL - Acute Lymphocytic Leukemia
term-group: SY
term-source: CDISC

Axiom
annotated source: Acute Lymphoblastic Leukemia
annotated property: has exact synonym
annotated target: ALL - Acute Lymphocytic Leukemia
term-group: SY
term-source: NCI

Axiom
annotated source: Acute Lymphoblastic Leukemia
annotated property: has exact synonym
annotated target: Acute Lymphoblastic Leukemia
term-group: PT
term-source: NCI

Axiom
annotated source: Acute Lymphoblastic Leukemia
annotated property: has exact synonym
annotated target: Acute Lymphoblastic Leukemia
term-group: PT
term-source: NICHD

Axiom
annotated source: Acute Lymphoblastic Leukemia
annotated property: has exact synonym
annotated target: Acute Lymphoblastic Leukemia
term-group: SY
term-source: CTRP

Axiom
annotated source: Acute Lymphoblastic Leukemia
annotated property: has exact synonym
annotated target: Acute Lymphoblastic Leukemia (ALL)
term-group: DN
term-source: CTRP

Axiom
annotated source: Acute Lymphoblastic Leukemia
annotated property: has exact synonym
annotated target: Acute Lymphoblastic Leukemia (ALL)
term-group: PT
term-source: CTRP

Axiom
annotated source: Acute Lymphoblastic Leukemia
annotated property: has exact synonym
annotated target: Acute Lymphocytic Leukaemia
term-group: AQS
term-source: NCI

Axiom
annotated source: Acute Lymphoblastic Leukemia
annotated property: has exact synonym
annotated target: Acute Lymphocytic Leukaemia
term-group: SY
term-source: CDISC

Axiom
annotated source: Acute Lymphoblastic Leukemia
annotated property: has exact synonym
annotated target: Acute Lymphocytic Leukemia
term-group: AQS
term-source: NCI

Axiom
annotated source: Acute Lymphoblastic Leukemia
annotated property: has exact synonym
annotated target: Acute Lymphocytic Leukemia
term-group: SY
term-source: NICHD

Axiom
annotated source: Acute Lymphoblastic Leukemia
annotated property: has exact synonym
annotated target: Acute Lymphocytic Leukemias
term-group: AQS
term-source: NCI

Axiom
annotated source: Acute Lymphoblastic Leukemia
annotated property: has exact synonym
annotated target: Acute Lymphocytic Leukemias
term-group: SY
term-source: CDISC

Axiom
annotated source: Acute Lymphoblastic Leukemia
annotated property: has exact synonym
annotated target: Acute Lymphogenous Leukemia
term-group: AQS
term-source: NCI

Axiom
annotated source: Acute Lymphoblastic Leukemia
annotated property: has exact synonym
annotated target: Acute Lymphogenous Leukemia
term-group: SY
term-source: CDISC

Axiom
annotated source: Acute Lymphoblastic Leukemia
annotated property: has exact synonym
annotated target: Acute Lymphoid Leukemia
term-group: SY
term-source: CDISC

Axiom
annotated source: Acute Lymphoblastic Leukemia
annotated property: has exact synonym
annotated target: Acute Lymphoid Leukemia
term-group: SY
term-source: NCI

Axiom
annotated source: Acute Lymphoblastic Leukemia
annotated property: has exact synonym
annotated target: Acute lymphoblastic leukemia
term-group: SY
term-source: CTEP
source-code: 10000846
subsource-name: SDC

Axiom
annotated source: Acute Lymphoblastic Leukemia
annotated property: has exact synonym
annotated target: Acute lymphoblastic leukemia, NOS
term-group: PT
term-source: CTEP
source-code: 10000846
subsource-name: SDC

Axiom
annotated source: Acute Lymphoblastic Leukemia
annotated property: has exact synonym
annotated target: LEUKEMIA, LYMPHOBLASTIC, MALIGNANT
term-group: PT
term-source: CDISC

Axiom
annotated source: Acute Lymphoblastic Leukemia
annotated property: has exact synonym
annotated target: Lymphoblastic Leukemia
term-group: SY
term-source: CDISC

Axiom
annotated source: Acute Lymphoblastic Leukemia
annotated property: has exact synonym
annotated target: Lymphoblastic Leukemia
term-group: SY
term-source: NCI

Axiom
annotated source: Acute Lymphoblastic Leukemia
annotated property: has exact synonym
annotated target: Precursor Cell Lymphoblastic Leukemia
term-group: SY
term-source: CDISC

Axiom
annotated source: Acute Lymphoblastic Leukemia
annotated property: has exact synonym
annotated target: Precursor Cell Lymphoblastic Leukemia
term-group: SY
term-source: NCI

Axiom
annotated source: Acute Lymphoblastic Leukemia
annotated property: has exact synonym
annotated target: Precursor Lymphoblasic Leukemia
term-group: SY
term-source: CDISC

Axiom
annotated source: Acute Lymphoblastic Leukemia
annotated property: has exact synonym
annotated target: Precursor Lymphoblastic Leukemia
term-group: SY
term-source: NCI

Axiom
annotated source: Acute Lymphoblastic Leukemia
annotated property: has exact synonym
annotated target: acute lymphoblastic leukemia
term-group: PT
term-source: NCI-GLOSS
source-code: CDR0000045586

Axiom
annotated source: Acute Lymphoblastic Leukemia
annotated property: has exact synonym
annotated target: acute lymphocytic leukemia
term-group: PT
term-source: NCI-GLOSS
source-code: CDR0000046332

Acute Myeloid Leukemia
type: Class
subclass of: Myeloid Leukemia
definition: A clonal expansion of myeloid blasts in the bone marrow, blood or other tissues. The classification of acute myeloid leukemias (AMLs) encompasses four major categories: 1) AML with recurrent genetic abnormalities; 2) AML with multilineage dysplasia; 3) Therapy-related AML; 4) AML not otherwise specified. The required bone marrow or peripheral blood blast percentage for the diagnosis of AML is 20% (WHO classification).
Has_NICHD_Parent: Leukemia
Concept_In_Subset: NCIT C116977
Concept_In_Subset: NCIT C118464
Concept_In_Subset: NCIT C126659
Concept_In_Subset: NCIT C132009
Concept_In_Subset: NCIT C90259
code: C3171
Semantic_Type: Neoplastic Process
Display_Name: Acute Myeloid Leukemia (AML)
Preferred_Name: Acute Myeloid Leukemia
UMLS_CUI: C0023467
Contributing_Source: CTRP
Contributing_Source: MedDRA
Contributing_Source: NICHD
ALT_DEFINITION: A rapidly progressive cancer of the blood and bone marrow consisting of the proliferation of abnormal myeloblasts, which are immature, dysfunctional white blood cells.
ALT_DEFINITION: An aggressive (fast-growing) disease in which too many myeloblasts (immature white blood cells that are not lymphoblasts) are found in the bone marrow and blood.
ICD-O-3_Code: 9861/3
Neoplastic_Status: Malignant
Legacy_Concept_Name: Acute_Myeloid_Leukemia
NICHD_Hierarchy_Term: Acute Myeloid Leukemia
has exact synonym: AML
has exact synonym: AML - Acute Myeloid Leukemia
has exact synonym: ANLL
has exact synonym: Acute Granulocytic Leukemia
has exact synonym: Acute Myeloblastic Leukemia
has exact synonym: Acute Myelocytic Leukemia
has exact synonym: Acute Myelogenous Leukemia
has exact synonym: Acute Myelogenous Leukemias
has exact synonym: Acute Myeloid Leukemia
has exact synonym: Acute Myeloid Leukemia (AML)
has exact synonym: Acute Nonlymphocytic Leukemia
has exact synonym: Hematopoeitic - Acute Myleogenous Leukemia (AML)
has exact synonym: acute myeloblastic leukemia
has exact synonym: acute myelogenous leukemia
has exact synonym: acute myeloid leukemia
has exact synonym: acute nonlymphocytic leukemia
in subset: oncotree slim

Axiom
annotated source: Acute Myeloid Leukemia
annotated property: definition
annotated target: A clonal expansion of myeloid blasts in the bone marrow, blood or other tissues. The classification of acute myeloid leukemias (AMLs) encompasses four major categories: 1) AML with recurrent genetic abnormalities; 2) AML with multilineage dysplasia; 3) Therapy-related AML; 4) AML not otherwise specified. The required bone marrow or peripheral blood blast percentage for the diagnosis of AML is 20% (WHO classification).
def-source: NCI

Axiom
annotated source: Acute Myeloid Leukemia
annotated property: ALT_DEFINITION
annotated target: A rapidly progressive cancer of the blood and bone marrow consisting of the proliferation of abnormal myeloblasts, which are immature, dysfunctional white blood cells.
def-source: NICHD

Axiom
annotated source: Acute Myeloid Leukemia
annotated property: ALT_DEFINITION
annotated target: An aggressive (fast-growing) disease in which too many myeloblasts (immature white blood cells that are not lymphoblasts) are found in the bone marrow and blood.
def-source: NCI-GLOSS

Axiom
annotated source: Acute Myeloid Leukemia
annotated property: has exact synonym
annotated target: AML
term-group: AB
term-source: NCI

Axiom
annotated source: Acute Myeloid Leukemia
annotated property: has exact synonym
annotated target: AML
term-group: PT
term-source: NCI-GLOSS
source-code: CDR0000044363

Axiom
annotated source: Acute Myeloid Leukemia
annotated property: has exact synonym
annotated target: AML
term-group: SY
term-source: NICHD

Axiom
annotated source: Acute Myeloid Leukemia
annotated property: has exact synonym
annotated target: AML - Acute Myeloid Leukemia
term-group: SY
term-source: NCI

Axiom
annotated source: Acute Myeloid Leukemia
annotated property: has exact synonym
annotated target: ANLL
term-group: AB
term-source: NCI

Axiom
annotated source: Acute Myeloid Leukemia
annotated property: has exact synonym
annotated target: ANLL
term-group: SY
term-source: NCI-GLOSS
source-code: CDR0000575436

Axiom
annotated source: Acute Myeloid Leukemia
annotated property: has exact synonym
annotated target: Acute Granulocytic Leukemia
term-group: SY
term-source: NICHD

Axiom
annotated source: Acute Myeloid Leukemia
annotated property: has exact synonym
annotated target: Acute Myeloblastic Leukemia
term-group: SY
term-source: NCI

Axiom
annotated source: Acute Myeloid Leukemia
annotated property: has exact synonym
annotated target: Acute Myelocytic Leukemia
term-group: AQS
term-source: NCI

Axiom
annotated source: Acute Myeloid Leukemia
annotated property: has exact synonym
annotated target: Acute Myelocytic Leukemia
term-group: SY
term-source: NICHD

Axiom
annotated source: Acute Myeloid Leukemia
annotated property: has exact synonym
annotated target: Acute Myelogenous Leukemia
term-group: SY
term-source: NCI

Axiom
annotated source: Acute Myeloid Leukemia
annotated property: has exact synonym
annotated target: Acute Myelogenous Leukemia
term-group: SY
term-source: NICHD

Axiom
annotated source: Acute Myeloid Leukemia
annotated property: has exact synonym
annotated target: Acute Myelogenous Leukemias
term-group: SY
term-source: NCI

Axiom
annotated source: Acute Myeloid Leukemia
annotated property: has exact synonym
annotated target: Acute Myeloid Leukemia
term-group: PT
term-source: NCI

Axiom
annotated source: Acute Myeloid Leukemia
annotated property: has exact synonym
annotated target: Acute Myeloid Leukemia
term-group: PT
term-source: NICHD

Axiom
annotated source: Acute Myeloid Leukemia
annotated property: has exact synonym
annotated target: Acute Myeloid Leukemia
term-group: SY
term-source: CTRP

Axiom
annotated source: Acute Myeloid Leukemia
annotated property: has exact synonym
annotated target: Acute Myeloid Leukemia
term-group: SY
term-source: NCI
source-code: TCGA
subsource-name: caDSR

Axiom
annotated source: Acute Myeloid Leukemia
annotated property: has exact synonym
annotated target: Acute Myeloid Leukemia (AML)
term-group: DN
term-source: CTRP

Axiom
annotated source: Acute Myeloid Leukemia
annotated property: has exact synonym
annotated target: Acute Myeloid Leukemia (AML)
term-group: PT
term-source: CTRP

Axiom
annotated source: Acute Myeloid Leukemia
annotated property: has exact synonym
annotated target: Acute Nonlymphocytic Leukemia
term-group: AQS
term-source: NCI

Axiom
annotated source: Acute Myeloid Leukemia
annotated property: has exact synonym
annotated target: Hematopoeitic - Acute Myleogenous Leukemia (AML)
term-group: SY
term-source: NCI

Axiom
annotated source: Acute Myeloid Leukemia
annotated property: has exact synonym
annotated target: acute myeloblastic leukemia
term-group: SY
term-source: NCI-GLOSS
source-code: CDR0000575435

Axiom
annotated source: Acute Myeloid Leukemia
annotated property: has exact synonym
annotated target: acute myelogenous leukemia
term-group: PT
term-source: NCI-GLOSS
source-code: CDR0000046757

Axiom
annotated source: Acute Myeloid Leukemia
annotated property: has exact synonym
annotated target: acute myeloid leukemia
term-group: PT
term-source: NCI-GLOSS
source-code: CDR0000046347

Axiom
annotated source: Acute Myeloid Leukemia
annotated property: has exact synonym
annotated target: acute nonlymphocytic leukemia
term-group: PT
term-source: NCI-GLOSS
source-code: CDR0000046215

Myeloid Leukemia
type: Class
subclass of: Leukemia
definition: A clonal proliferation of myeloid cells and their precursors in the bone marrow, peripheral blood, and spleen. When the proliferating cells are immature myeloid cells and myeloblasts, it is called acute myeloid leukemia. When the proliferating myeloid cells are neutrophils, it is called chronic myelogenous leukemia.
Concept_In_Subset: NCIT C61410
Concept_In_Subset: NCIT C77526
Concept_In_Subset: NCIT C88025
code: C3172
Semantic_Type: Neoplastic Process
Preferred_Name: Myeloid Leukemia
UMLS_CUI: C0023470
Contributing_Source: CDISC
ALT_DEFINITION: A progressive, proliferative disease of blood cells, originating from immature granulocytes.
ICD-O-3_Code: 9860/3
Neoplastic_Status: Malignant
Legacy_Concept_Name: Myeloid_Leukemia
has exact synonym: LEUKEMIA, GRANULOCYTIC, MALIGNANT
has exact synonym: Leukemia Granulocytic
has exact synonym: Leukemia Myeloid
has exact synonym: Myelocytic Leukemia
has exact synonym: Myelogenous Leukemia
has exact synonym: Myeloid Leukemia
has exact synonym: Non-Lymphoblastic Leukemia
has exact synonym: Non-Lymphocytic Leukemia
has exact synonym: Non-lymphoblastic Leukemia
has exact synonym: Non-lymphocytic Leukemia
in subset: oncotree slim

Axiom
annotated source: Myeloid Leukemia
annotated property: definition
annotated target: A clonal proliferation of myeloid cells and their precursors in the bone marrow, peripheral blood, and spleen. When the proliferating cells are immature myeloid cells and myeloblasts, it is called acute myeloid leukemia. When the proliferating myeloid cells are neutrophils, it is called chronic myelogenous leukemia.
def-source: NCI

Axiom
annotated source: Myeloid Leukemia
annotated property: ALT_DEFINITION
annotated target: A progressive, proliferative disease of blood cells, originating from immature granulocytes.
def-source: CDISC

Axiom
annotated source: Myeloid Leukemia
annotated property: has exact synonym
annotated target: LEUKEMIA, GRANULOCYTIC, MALIGNANT
term-group: PT
term-source: CDISC

Axiom
annotated source: Myeloid Leukemia
annotated property: has exact synonym
annotated target: Leukemia Granulocytic
term-group: SY
term-source: CDISC

Axiom
annotated source: Myeloid Leukemia
annotated property: has exact synonym
annotated target: Leukemia Myeloid
term-group: SY
term-source: CDISC

Axiom
annotated source: Myeloid Leukemia
annotated property: has exact synonym
annotated target: Myelocytic Leukemia
term-group: SY
term-source: CDISC

Axiom
annotated source: Myeloid Leukemia
annotated property: has exact synonym
annotated target: Myelocytic Leukemia
term-group: SY
term-source: NCI

Axiom
annotated source: Myeloid Leukemia
annotated property: has exact synonym
annotated target: Myelogenous Leukemia
term-group: SY
term-source: CDISC

Axiom
annotated source: Myeloid Leukemia
annotated property: has exact synonym
annotated target: Myelogenous Leukemia
term-group: SY
term-source: NCI

Axiom
annotated source: Myeloid Leukemia
annotated property: has exact synonym
annotated target: Myeloid Leukemia
term-group: PT
term-source: CTRP

Axiom
annotated source: Myeloid Leukemia
annotated property: has exact synonym
annotated target: Myeloid Leukemia
term-group: PT
term-source: NCI

Axiom
annotated source: Myeloid Leukemia
annotated property: has exact synonym
annotated target: Non-Lymphoblastic Leukemia
term-group: AQS
term-source: NCI

Axiom
annotated source: Myeloid Leukemia
annotated property: has exact synonym
annotated target: Non-Lymphocytic Leukemia
term-group: AQS
term-source: NCI

Axiom
annotated source: Myeloid Leukemia
annotated property: has exact synonym
annotated target: Non-lymphoblastic Leukemia
term-group: SY
term-source: CDISC

Axiom
annotated source: Myeloid Leukemia
annotated property: has exact synonym
annotated target: Non-lymphocytic Leukemia
term-group: SY
term-source: CDISC

T Acute Lymphoblastic Leukemia
type: Class
subclass of: Acute Lymphoblastic Leukemia
definition: Acute lymphoblastic leukemia of T-cell origin. It comprises about 15% of childhood cases and 25% of adult cases. It is more common in males than females. (WHO, 2001)
Has_NICHD_Parent: Acute Lymphoblastic Leukemia
Concept_In_Subset: NCIT C102905
Concept_In_Subset: NCIT C103123
Concept_In_Subset: NCIT C126659
Concept_In_Subset: NCIT C132009
Concept_In_Subset: NCIT C90259
code: C3183
Semantic_Type: Neoplastic Process
Preferred_Name: T Acute Lymphoblastic Leukemia
UMLS_CUI: C1961099
Contributing_Source: CTEP
Contributing_Source: NICHD
ALT_DEFINITION: An acute lymphoblastic leukemia of T-lineage origin.
ALT_DEFINITION: An aggressive (fast-growing) type of leukemia (blood cancer) in which too many T-cell lymphoblasts (immature white blood cells) are found in the bone marrow and blood.
ICD-O-3_Code: 9837/3
Neoplastic_Status: Malignant
Legacy_Concept_Name: Precursor_T_Lymphoblastic_Leukemia
NICHD_Hierarchy_Term: T Acute Lymphoblastic Leukemia
has exact synonym: Acute T Cell Leukemia
has exact synonym: Acute T Cell Lymphoblastic Leukemia
has exact synonym: Acute T Cell Lymphocytic Leukemia
has exact synonym: Acute T-Cell Leukemia
has exact synonym: Acute T-Cell Lymphoblastic Leukemia
has exact synonym: Acute T-Cell Lymphocytic Leukemia
has exact synonym: Precursor T-Lymphoblastic Leukemia
has exact synonym: Precursor T-lymphoblastic leukemia (T-cell ALL)
has exact synonym: T Acute Lymphoblastic Leukemia
has exact synonym: T-ALL
has exact synonym: T-Cell Acute Lymphoblastic Leukemia
has exact synonym: T-Cell Type Acute Leukemia
has exact synonym: T-cell ALL
has exact synonym: T-cell acute lymphoblastic leukemia
has exact synonym: T-cell acute lymphocytic leukemia
has exact synonym: precursor T-lymphoblastic leukemia
in subset: oncotree slim

Axiom
annotated source: T Acute Lymphoblastic Leukemia
annotated property: definition
annotated target: Acute lymphoblastic leukemia of T-cell origin. It comprises about 15% of childhood cases and 25% of adult cases. It is more common in males than females. (WHO, 2001)
def-source: NCI

Axiom
annotated source: T Acute Lymphoblastic Leukemia
annotated property: ALT_DEFINITION
annotated target: An acute lymphoblastic leukemia of T-lineage origin.
def-source: NICHD

Axiom
annotated source: T Acute Lymphoblastic Leukemia
annotated property: ALT_DEFINITION
annotated target: An aggressive (fast-growing) type of leukemia (blood cancer) in which too many T-cell lymphoblasts (immature white blood cells) are found in the bone marrow and blood.
def-source: NCI-GLOSS

Axiom
annotated source: T Acute Lymphoblastic Leukemia
annotated property: has exact synonym
annotated target: Acute T Cell Leukemia
term-group: SY
term-source: NCI

Axiom
annotated source: T Acute Lymphoblastic Leukemia
annotated property: has exact synonym
annotated target: Acute T Cell Lymphoblastic Leukemia
term-group: SY
term-source: NCI

Axiom
annotated source: T Acute Lymphoblastic Leukemia
annotated property: has exact synonym
annotated target: Acute T Cell Lymphocytic Leukemia
term-group: AQS
term-source: NCI

Axiom
annotated source: T Acute Lymphoblastic Leukemia
annotated property: has exact synonym
annotated target: Acute T-Cell Leukemia
term-group: SY
term-source: NCI

Axiom
annotated source: T Acute Lymphoblastic Leukemia
annotated property: has exact synonym
annotated target: Acute T-Cell Lymphoblastic Leukemia
term-group: SY
term-source: NCI

Axiom
annotated source: T Acute Lymphoblastic Leukemia
annotated property: has exact synonym
annotated target: Acute T-Cell Lymphocytic Leukemia
term-group: AQS
term-source: NCI

Axiom
annotated source: T Acute Lymphoblastic Leukemia
annotated property: has exact synonym
annotated target: Precursor T-Lymphoblastic Leukemia
term-group: SY
term-source: NCI

Axiom
annotated source: T Acute Lymphoblastic Leukemia
annotated property: has exact synonym
annotated target: Precursor T-lymphoblastic leukemia (T-cell ALL)
term-group: PT
term-source: CTEP
source-code: 10054569
subsource-name: SDC

Axiom
annotated source: T Acute Lymphoblastic Leukemia
annotated property: has exact synonym
annotated target: T Acute Lymphoblastic Leukemia
term-group: PT
term-source: NCI

Axiom
annotated source: T Acute Lymphoblastic Leukemia
annotated property: has exact synonym
annotated target: T Acute Lymphoblastic Leukemia
term-group: PT
term-source: NICHD

Axiom
annotated source: T Acute Lymphoblastic Leukemia
annotated property: has exact synonym
annotated target: T-ALL
term-group: AB
term-source: NCI

Axiom
annotated source: T Acute Lymphoblastic Leukemia
annotated property: has exact synonym
annotated target: T-ALL
term-group: SY
term-source: NICHD

Axiom
annotated source: T Acute Lymphoblastic Leukemia
annotated property: has exact synonym
annotated target: T-Cell Acute Lymphoblastic Leukemia
term-group: SY
term-source: NCI

Axiom
annotated source: T Acute Lymphoblastic Leukemia
annotated property: has exact synonym
annotated target: T-Cell Type Acute Leukemia
term-group: SY
term-source: NCI

Axiom
annotated source: T Acute Lymphoblastic Leukemia
annotated property: has exact synonym
annotated target: T-cell ALL
term-group: SY
term-source: CTEP
source-code: 10054569
subsource-name: SDC

Axiom
annotated source: T Acute Lymphoblastic Leukemia
annotated property: has exact synonym
annotated target: T-cell acute lymphoblastic leukemia
term-group: PT
term-source: NCI-GLOSS
source-code: CDR0000509731

Axiom
annotated source: T Acute Lymphoblastic Leukemia
annotated property: has exact synonym
annotated target: T-cell acute lymphocytic leukemia
term-group: SY
term-source: NCI-GLOSS
source-code: CDR0000509747

Axiom
annotated source: T Acute Lymphoblastic Leukemia
annotated property: has exact synonym
annotated target: precursor T-lymphoblastic leukemia
term-group: SY
term-source: NCI-GLOSS
source-code: CDR0000509729

Liposarcoma
type: Class
definition: A usually painless malignant tumor that arises from adipose tissue. Microscopically, it may contain a spectrum of neoplastic adipocytes ranging from lipoblasts to pleomorphic malignant adipocytes. Morphologic variants include: well differentiated, dedifferentiated, pleomorphic, and myxoid liposarcoma. The metastatic potential is higher in less differentiated tumors.
Concept_In_Subset: NCIT C102905
Concept_In_Subset: NCIT C103117
Concept_In_Subset: NCIT C126659
Concept_In_Subset: NCIT C61410
Concept_In_Subset: NCIT C77526
Concept_In_Subset: NCIT C88025
code: C3194
Semantic_Type: Neoplastic Process
Display_Name: Liposarcoma
Preferred_Name: Liposarcoma
UMLS_CUI: C0023827
Contributing_Source: CDISC
Contributing_Source: CTEP
ALT_DEFINITION: A malignant neoplasm composed of adipose tissue.
ICD-O-3_Code: 8850/3
Neoplastic_Status: Malignant
Legacy_Concept_Name: Liposarcoma
has exact synonym: LIPOSARCOMA, MALIGNANT
has exact synonym: Liposarcoma
has exact synonym: Liposarcoma Not Otherwise Specified
has exact synonym: liposarcoma
in subset: oncotree slim

Axiom
annotated source: Liposarcoma
annotated property: definition
annotated target: A usually painless malignant tumor that arises from adipose tissue. Microscopically, it may contain a spectrum of neoplastic adipocytes ranging from lipoblasts to pleomorphic malignant adipocytes. Morphologic variants include: well differentiated, dedifferentiated, pleomorphic, and myxoid liposarcoma. The metastatic potential is higher in less differentiated tumors.
def-source: NCI

Axiom
annotated source: Liposarcoma
annotated property: ALT_DEFINITION
annotated target: A malignant neoplasm composed of adipose tissue.
def-source: CDISC

Axiom
annotated source: Liposarcoma
annotated property: has exact synonym
annotated target: LIPOSARCOMA, MALIGNANT
term-group: PT
term-source: CDISC

Axiom
annotated source: Liposarcoma
annotated property: has exact synonym
annotated target: Liposarcoma
term-group: PT
term-source: CTEP
source-code: 10024631
subsource-name: SDC

Axiom
annotated source: Liposarcoma
annotated property: has exact synonym
annotated target: Liposarcoma
term-group: PT
term-source: CTRP

Axiom
annotated source: Liposarcoma
annotated property: has exact synonym
annotated target: Liposarcoma
term-group: PT
term-source: NCI

Axiom
annotated source: Liposarcoma
annotated property: has exact synonym
annotated target: Liposarcoma Not Otherwise Specified
term-group: SY
term-source: NCI

Axiom
annotated source: Liposarcoma
annotated property: has exact synonym
annotated target: liposarcoma
term-group: PT
term-source: NCI-GLOSS
source-code: CDR0000046028

Lymphoma
type: Class
definition: A malignant (clonal) proliferation of B- lymphocytes or T- lymphocytes which involves the lymph nodes, bone marrow and/or extranodal sites. This category includes Non-Hodgkin lymphomas and Hodgkin lymphomas.
Has_CDRH_Parent: NCIT C9305
Has_NICHD_Parent: NCIT C9305
Concept_In_Subset: NCIT C102905
Concept_In_Subset: NCIT C103136
Concept_In_Subset: NCIT C116977
Concept_In_Subset: NCIT C118464
Concept_In_Subset: NCIT C126659
Concept_In_Subset: NCIT C54450
Concept_In_Subset: NCIT C61410
Concept_In_Subset: NCIT C62596
Concept_In_Subset: NCIT C77526
Concept_In_Subset: NCIT C88025
Concept_In_Subset: NCIT C90259
code: C3208
Semantic_Type: Neoplastic Process
Display_Name: Lymphoma
Preferred_Name: Lymphoma
UMLS_CUI: C0024299
Contributing_Source: CDISC
Contributing_Source: CTEP
Contributing_Source: CTRP
Contributing_Source: FDA
Contributing_Source: MedDRA
Contributing_Source: NICHD
ALT_DEFINITION: A malignant neoplasm composed of lymphocytes of B- or T/NK-cell phenotype.
ALT_DEFINITION: A malignant neoplasm of the lymphatic system that is comprised of abnormal lymphocytes.
ALT_DEFINITION: Cancer that begins in cells of the immune system. There are two basic categories of lymphomas. One kind is Hodgkin lymphoma, which is marked by the presence of a type of cell called the Reed-Sternberg cell. The other category is non-Hodgkin lymphomas, which includes a large, diverse group of cancers of immune system cells. Non-Hodgkin lymphomas can be further divided into cancers that have an indolent (slow-growing) course and those that have an aggressive (fast-growing) course. These subtypes behave and respond to treatment differently. Both Hodgkin and non-Hodgkin lymphomas can occur in children and adults, and prognosis and treatment depend on the stage and the type of cancer.
ICD-O-3_Code: 9590/3
Neoplastic_Status: Malignant
Legacy_Concept_Name: Lymphoma
NICHD_Hierarchy_Term: Lymphoma
has exact synonym: LYMPHOMA, MALIGNANT
has exact synonym: Lymphoma
has exact synonym: Lymphoma (Hodgkin and Non-Hodgkin)
has exact synonym: Lymphoma (Hodgkin's and Non-Hodgkin's)
has exact synonym: Lymphoma, NOS
has exact synonym: Lymphomatous
has exact synonym: Malignant Lymphoma
has exact synonym: lymphoma
in subset: oncotree slim

Axiom
annotated source: Lymphoma
annotated property: definition
annotated target: A malignant (clonal) proliferation of B- lymphocytes or T- lymphocytes which involves the lymph nodes, bone marrow and/or extranodal sites. This category includes Non-Hodgkin lymphomas and Hodgkin lymphomas.
def-source: NCI

Axiom
annotated source: Lymphoma
annotated property: ALT_DEFINITION
annotated target: A malignant neoplasm composed of lymphocytes of B- or T/NK-cell phenotype.
def-source: CDISC

Axiom
annotated source: Lymphoma
annotated property: ALT_DEFINITION
annotated target: A malignant neoplasm of the lymphatic system that is comprised of abnormal lymphocytes.
def-source: NICHD

Axiom
annotated source: Lymphoma
annotated property: ALT_DEFINITION
annotated target: Cancer that begins in cells of the immune system. There are two basic categories of lymphomas. One kind is Hodgkin lymphoma, which is marked by the presence of a type of cell called the Reed-Sternberg cell. The other category is non-Hodgkin lymphomas, which includes a large, diverse group of cancers of immune system cells. Non-Hodgkin lymphomas can be further divided into cancers that have an indolent (slow-growing) course and those that have an aggressive (fast-growing) course. These subtypes behave and respond to treatment differently. Both Hodgkin and non-Hodgkin lymphomas can occur in children and adults, and prognosis and treatment depend on the stage and the type of cancer.
def-source: NCI-GLOSS

Axiom
annotated source: Lymphoma
annotated property: has exact synonym
annotated target: LYMPHOMA, MALIGNANT
term-group: PT
term-source: CDISC

Axiom
annotated source: Lymphoma
annotated property: has exact synonym
annotated target: Lymphoma
term-group: DN
term-source: CTRP

Axiom
annotated source: Lymphoma
annotated property: has exact synonym
annotated target: Lymphoma
term-group: PT
term-source: CTRP

Axiom
annotated source: Lymphoma
annotated property: has exact synonym
annotated target: Lymphoma
term-group: PT
term-source: FDA
source-code: 3263
subsource-name: CDRH

Axiom
annotated source: Lymphoma
annotated property: has exact synonym
annotated target: Lymphoma
term-group: PT
term-source: NCI

Axiom
annotated source: Lymphoma
annotated property: has exact synonym
annotated target: Lymphoma
term-group: PT
term-source: NICHD

Axiom
annotated source: Lymphoma
annotated property: has exact synonym
annotated target: Lymphoma
term-group: SY
term-source: NCI
source-code: TCGA
subsource-name: caDSR

Axiom
annotated source: Lymphoma
annotated property: has exact synonym
annotated target: Lymphoma (Hodgkin and Non-Hodgkin)
term-group: SY
term-source: CDISC

Axiom
annotated source: Lymphoma
annotated property: has exact synonym
annotated target: Lymphoma (Hodgkin and Non-Hodgkin)
term-group: SY
term-source: NCI

Axiom
annotated source: Lymphoma
annotated property: has exact synonym
annotated target: Lymphoma (Hodgkin's and Non-Hodgkin's)
term-group: SY
term-source: CDISC

Axiom
annotated source: Lymphoma
annotated property: has exact synonym
annotated target: Lymphoma (Hodgkin's and Non-Hodgkin's)
term-group: SY
term-source: NCI

Axiom
annotated source: Lymphoma
annotated property: has exact synonym
annotated target: Lymphoma, NOS
term-group: PT
term-source: CTEP
source-code: 10025316
subsource-name: SDC

Axiom
annotated source: Lymphoma
annotated property: has exact synonym
annotated target: Lymphomatous
term-group: AD
term-source: NCI

Axiom
annotated source: Lymphoma
annotated property: has exact synonym
annotated target: Malignant Lymphoma
term-group: SY
term-source: CDISC

Axiom
annotated source: Lymphoma
annotated property: has exact synonym
annotated target: Malignant Lymphoma
term-group: SY
term-source: NCI

Axiom
annotated source: Lymphoma
annotated property: has exact synonym
annotated target: lymphoma
term-group: PT
term-source: NCI-GLOSS
source-code: CDR0000045368

Follicular Lymphoma
type: Class
definition: A neoplasm of follicle centre B cells which has at least a partial follicular pattern. Follicular lymphomas comprise about 35% of adult non-Hodgkin lymphomas in the U.S. and 22% worldwide. Most patients have widespread disease at diagnosis. Morphologically, follicular lymphomas are classified as Grade 1, Grade 2, and Grade 3, depending on the percentage of the large lymphocytes present. The vast majority of cases (70-95%) express the BCL-2 rearrangement [t(14;18)]. Histological grade correlates with prognosis. Grades 1 and 2 follicular lymphomas are indolent and grade 3 is more aggressive (adapted from WHO, 2001).
Concept_In_Subset: NCIT C102905
Concept_In_Subset: NCIT C103133
Concept_In_Subset: NCIT C116977
Concept_In_Subset: NCIT C126659
Concept_In_Subset: NCIT C61410
Concept_In_Subset: NCIT C77526
Concept_In_Subset: NCIT C88025
code: C3209
Semantic_Type: Neoplastic Process
Display_Name: Follicular Lymphoma
Preferred_Name: Follicular Lymphoma
UMLS_CUI: C0024301
Contributing_Source: CDISC
Contributing_Source: CTEP
Contributing_Source: CTRP
ALT_DEFINITION: A neoplasm of lymphoid cells which has at least a partial follicular pattern.
ALT_DEFINITION: A type of B-cell non-Hodgkin lymphoma (cancer of the immune system) that is usually indolent (slow-growing). The tumor cells grow as groups to form nodules. There are several subtypes of follicular lymphoma.
ICD-O-3_Code: 9690/3
Neoplastic_Status: Malignant
Legacy_Concept_Name: Follicular_Lymphoma
has exact synonym: Follicle Center Lymphoma
has exact synonym: Follicular Centre Cell Lymphoma
has exact synonym: Follicular Lymphoma
has exact synonym: Follicular Non-Hodgkin Lymphoma
has exact synonym: Follicular Non-Hodgkin's Lymphoma
has exact synonym: Follicular lymphoma
has exact synonym: LYMPHOMA, FOLLICULAR, MALIGNANT
has exact synonym: Lymphoma, Follicular Centre Cell
has exact synonym: follicular lymphoma
in subset: oncotree slim

Axiom
annotated source: Follicular Lymphoma
annotated property: definition
annotated target: A neoplasm of follicle centre B cells which has at least a partial follicular pattern. Follicular lymphomas comprise about 35% of adult non-Hodgkin lymphomas in the U.S. and 22% worldwide. Most patients have widespread disease at diagnosis. Morphologically, follicular lymphomas are classified as Grade 1, Grade 2, and Grade 3, depending on the percentage of the large lymphocytes present. The vast majority of cases (70-95%) express the BCL-2 rearrangement [t(14;18)]. Histological grade correlates with prognosis. Grades 1 and 2 follicular lymphomas are indolent and grade 3 is more aggressive (adapted from WHO, 2001).
def-source: NCI

Axiom
annotated source: Follicular Lymphoma
annotated property: ALT_DEFINITION
annotated target: A neoplasm of lymphoid cells which has at least a partial follicular pattern.
def-source: CDISC

Axiom
annotated source: Follicular Lymphoma
annotated property: ALT_DEFINITION
annotated target: A type of B-cell non-Hodgkin lymphoma (cancer of the immune system) that is usually indolent (slow-growing). The tumor cells grow as groups to form nodules. There are several subtypes of follicular lymphoma.
def-source: NCI-GLOSS

Axiom
annotated source: Follicular Lymphoma
annotated property: has exact synonym
annotated target: Follicle Center Lymphoma
term-group: SY
term-source: CDISC

Axiom
annotated source: Follicular Lymphoma
annotated property: has exact synonym
annotated target: Follicle Center Lymphoma
term-group: SY
term-source: NCI

Axiom
annotated source: Follicular Lymphoma
annotated property: has exact synonym
annotated target: Follicular Centre Cell Lymphoma
term-group: SY
term-source: CDISC

Axiom
annotated source: Follicular Lymphoma
annotated property: has exact synonym
annotated target: Follicular Lymphoma
term-group: DN
term-source: CTRP

Axiom
annotated source: Follicular Lymphoma
annotated property: has exact synonym
annotated target: Follicular Lymphoma
term-group: PT
term-source: NCI

Axiom
annotated source: Follicular Lymphoma
annotated property: has exact synonym
annotated target: Follicular Lymphoma
term-group: SY
term-source: NCI
source-code: TCGA
subsource-name: caDSR

Axiom
annotated source: Follicular Lymphoma
annotated property: has exact synonym
annotated target: Follicular Non-Hodgkin Lymphoma
term-group: SY
term-source: CDISC

Axiom
annotated source: Follicular Lymphoma
annotated property: has exact synonym
annotated target: Follicular Non-Hodgkin Lymphoma
term-group: SY
term-source: NCI

Axiom
annotated source: Follicular Lymphoma
annotated property: has exact synonym
annotated target: Follicular Non-Hodgkin's Lymphoma
term-group: SY
term-source: CDISC

Axiom
annotated source: Follicular Lymphoma
annotated property: has exact synonym
annotated target: Follicular Non-Hodgkin's Lymphoma
term-group: SY
term-source: NCI

Axiom
annotated source: Follicular Lymphoma
annotated property: has exact synonym
annotated target: Follicular lymphoma
term-group: PT
term-source: CTEP
source-code: 10016896
subsource-name: SDC

Axiom
annotated source: Follicular Lymphoma
annotated property: has exact synonym
annotated target: LYMPHOMA, FOLLICULAR, MALIGNANT
term-group: PT
term-source: CDISC

Axiom
annotated source: Follicular Lymphoma
annotated property: has exact synonym
annotated target: Lymphoma, Follicular Centre Cell
term-group: SY
term-source: CDISC

Axiom
annotated source: Follicular Lymphoma
annotated property: has exact synonym
annotated target: follicular lymphoma
term-group: PT
term-source: NCI-GLOSS
source-code: CDR0000428287

Non-Hodgkin Lymphoma
type: Class
subclass of: Lymphoma
definition: Distinct from Hodgkin lymphoma both morphologically and biologically, non-Hodgkin lymphoma (NHL) is characterized by the absence of Reed-Sternberg cells, can occur at any age, and usually presents as a localized or generalized lymphadenopathy associated with fever and weight loss. The clinical course varies according to the morphologic type. NHL is clinically classified as indolent, aggressive, or having a variable clinical course. NHL can be of B-or T-/NK-cell lineage.
Has_NICHD_Parent: Lymphoma
Concept_In_Subset: NCIT C102905
Concept_In_Subset: NCIT C103133
Concept_In_Subset: NCIT C116977
Concept_In_Subset: NCIT C118464
Concept_In_Subset: NCIT C126659
Concept_In_Subset: NCIT C90259
code: C3211
Semantic_Type: Neoplastic Process
Display_Name: Non-Hodgkin Lymphoma
Preferred_Name: Non-Hodgkin Lymphoma
UMLS_CUI: C0024305
Contributing_Source: CTEP
Contributing_Source: CTRP
Contributing_Source: MedDRA
Contributing_Source: NICHD
ALT_DEFINITION: A malignant neoplasm of the lymphatic system that is comprised of abnormal lymphocytes in the absence of Reed-Sternberg cells.
ALT_DEFINITION: Any of a large group of cancers of lymphocytes (white blood cells). NHLs can occur at any age and are often marked by lymph nodes that are larger than normal, fever, and weight loss. There are many different types of NHL. These types can be divided into aggressive (fast-growing) and indolent (slow-growing) types, and they can be formed from either B-cells or T-cells. B-cell NHLs include Burkitt lymphoma, chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL), diffuse large B-cell lymphoma, follicular lymphoma, immunoblastic large cell lymphoma, precursor B-lymphoblastic lymphoma, and mantle cell lymphoma. T-cell NHLs include mycosis fungoides, anaplastic large cell lymphoma, and precursor T-lymphoblastic lymphoma. Lymphomas that occur after bone marrow or stem cell transplantation are usually B-cell NHLs. Prognosis and treatment depend on the stage and type of disease.
ICD-O-3_Code: 9591/3
Neoplastic_Status: Malignant
Legacy_Concept_Name: Non-Hodgkin_s_Lymphoma
NICHD_Hierarchy_Term: Non-Hodgkin Lymphoma
has exact synonym: NHL
has exact synonym: NHL, NOS
has exact synonym: Non-Hodgkin Lymphoma
has exact synonym: Non-Hodgkin lymphoma, NOS
has exact synonym: Non-Hodgkin's Lymphoma
has exact synonym: Non-Hodgkin's Lymphoma (NHL)
has exact synonym: non-Hodgkin lymphoma
in subset: oncotree slim

Axiom
annotated source: Non-Hodgkin Lymphoma
annotated property: definition
annotated target: Distinct from Hodgkin lymphoma both morphologically and biologically, non-Hodgkin lymphoma (NHL) is characterized by the absence of Reed-Sternberg cells, can occur at any age, and usually presents as a localized or generalized lymphadenopathy associated with fever and weight loss. The clinical course varies according to the morphologic type. NHL is clinically classified as indolent, aggressive, or having a variable clinical course. NHL can be of B-or T-/NK-cell lineage.
def-source: NCI

Axiom
annotated source: Non-Hodgkin Lymphoma
annotated property: ALT_DEFINITION
annotated target: A malignant neoplasm of the lymphatic system that is comprised of abnormal lymphocytes in the absence of Reed-Sternberg cells.
def-source: NICHD

Axiom
annotated source: Non-Hodgkin Lymphoma
annotated property: ALT_DEFINITION
annotated target: Any of a large group of cancers of lymphocytes (white blood cells). NHLs can occur at any age and are often marked by lymph nodes that are larger than normal, fever, and weight loss. There are many different types of NHL. These types can be divided into aggressive (fast-growing) and indolent (slow-growing) types, and they can be formed from either B-cells or T-cells. B-cell NHLs include Burkitt lymphoma, chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL), diffuse large B-cell lymphoma, follicular lymphoma, immunoblastic large cell lymphoma, precursor B-lymphoblastic lymphoma, and mantle cell lymphoma. T-cell NHLs include mycosis fungoides, anaplastic large cell lymphoma, and precursor T-lymphoblastic lymphoma. Lymphomas that occur after bone marrow or stem cell transplantation are usually B-cell NHLs. Prognosis and treatment depend on the stage and type of disease.
def-source: NCI-GLOSS

Axiom
annotated source: Non-Hodgkin Lymphoma
annotated property: has exact synonym
annotated target: NHL
term-group: AB
term-source: NCI

Axiom
annotated source: Non-Hodgkin Lymphoma
annotated property: has exact synonym
annotated target: NHL
term-group: PT
term-source: NCI-GLOSS
source-code: CDR0000430869

Axiom
annotated source: Non-Hodgkin Lymphoma
annotated property: has exact synonym
annotated target: NHL, NOS
term-group: SY
term-source: CTEP
source-code: 10029593
subsource-name: SDC

Axiom
annotated source: Non-Hodgkin Lymphoma
annotated property: has exact synonym
annotated target: Non-Hodgkin Lymphoma
term-group: DN
term-source: CTRP

Axiom
annotated source: Non-Hodgkin Lymphoma
annotated property: has exact synonym
annotated target: Non-Hodgkin Lymphoma
term-group: PT
term-source: CTRP

Axiom
annotated source: Non-Hodgkin Lymphoma
annotated property: has exact synonym
annotated target: Non-Hodgkin Lymphoma
term-group: PT
term-source: NCI

Axiom
annotated source: Non-Hodgkin Lymphoma
annotated property: has exact synonym
annotated target: Non-Hodgkin Lymphoma
term-group: PT
term-source: NICHD

Axiom
annotated source: Non-Hodgkin Lymphoma
annotated property: has exact synonym
annotated target: Non-Hodgkin lymphoma, NOS
term-group: PT
term-source: CTEP
source-code: 10029593
subsource-name: SDC

Axiom
annotated source: Non-Hodgkin Lymphoma
annotated property: has exact synonym
annotated target: Non-Hodgkin's Lymphoma
term-group: SY
term-source: NCI

Axiom
annotated source: Non-Hodgkin Lymphoma
annotated property: has exact synonym
annotated target: Non-Hodgkin's Lymphoma
term-group: SY
term-source: NICHD

Axiom
annotated source: Non-Hodgkin Lymphoma
annotated property: has exact synonym
annotated target: Non-Hodgkin's Lymphoma (NHL)
term-group: SY
term-source: NCI

Axiom
annotated source: Non-Hodgkin Lymphoma
annotated property: has exact synonym
annotated target: non-Hodgkin lymphoma
term-group: PT
term-source: NCI-GLOSS
source-code: CDR0000045148

Medulloblastoma
type: Class
definition: A malignant, invasive embryonal neoplasm arising from the cerebellum. It occurs predominantly in children and has the tendency to metastasize via the cerebrospinal fluid pathways. Signs and symptoms include truncal ataxia, disturbed gait, lethargy, headache, and vomiting. There are four histologic variants: classic medulloblastoma, large cell/anaplastic medulloblastoma, desmoplastic/nodular medulloblastoma, and medulloblastoma with extensive nodularity.
Has_NICHD_Parent: NCIT C3268
Concept_In_Subset: NCIT C102905
Concept_In_Subset: NCIT C103046
Concept_In_Subset: NCIT C118464
Concept_In_Subset: NCIT C126659
Concept_In_Subset: NCIT C61410
Concept_In_Subset: NCIT C77526
Concept_In_Subset: NCIT C88025
Concept_In_Subset: NCIT C90259
Concept_In_Subset: NCIT C99147
code: C3222
Semantic_Type: Neoplastic Process
Preferred_Name: Medulloblastoma
UMLS_CUI: C0025149
Contributing_Source: CDISC
Contributing_Source: CTEP
Contributing_Source: MedDRA
Contributing_Source: NICHD
ALT_DEFINITION: A malignant brain tumor that begins in the lower part of the brain and that can spread to the spine or to other parts of the body. Medulloblastomas are a type of primitive neuroectodermal tumor (PNET).
ALT_DEFINITION: A malignant, invasive embryonal neoplasm arising from the cerebellum.
ALT_DEFINITION: A rapidly progressive cancer of the brain that originates in the cerebellum.
ICD-O-3_Code: 9470/3
Neoplastic_Status: Malignant
Legacy_Concept_Name: Medulloblastoma
NICHD_Hierarchy_Term: Medulloblastoma
has exact synonym: MEDULLOBLASTOMA, MALIGNANT
has exact synonym: Medulloblastoma
has exact synonym: Medulloblastomas
has exact synonym: medulloblastoma
in subset: oncotree slim

Axiom
annotated source: Medulloblastoma
annotated property: definition
annotated target: A malignant, invasive embryonal neoplasm arising from the cerebellum. It occurs predominantly in children and has the tendency to metastasize via the cerebrospinal fluid pathways. Signs and symptoms include truncal ataxia, disturbed gait, lethargy, headache, and vomiting. There are four histologic variants: classic medulloblastoma, large cell/anaplastic medulloblastoma, desmoplastic/nodular medulloblastoma, and medulloblastoma with extensive nodularity.
def-source: NCI

Axiom
annotated source: Medulloblastoma
annotated property: ALT_DEFINITION
annotated target: A malignant brain tumor that begins in the lower part of the brain and that can spread to the spine or to other parts of the body. Medulloblastomas are a type of primitive neuroectodermal tumor (PNET).
def-source: NCI-GLOSS

Axiom
annotated source: Medulloblastoma
annotated property: ALT_DEFINITION
annotated target: A malignant, invasive embryonal neoplasm arising from the cerebellum.
def-source: CDISC

Axiom
annotated source: Medulloblastoma
annotated property: ALT_DEFINITION
annotated target: A rapidly progressive cancer of the brain that originates in the cerebellum.
def-source: NICHD

Axiom
annotated source: Medulloblastoma
annotated property: has exact synonym
annotated target: MEDULLOBLASTOMA, MALIGNANT
term-group: PT
term-source: CDISC

Axiom
annotated source: Medulloblastoma
annotated property: has exact synonym
annotated target: Medulloblastoma
term-group: PT
term-source: CTEP
source-code: 10027107
subsource-name: SDC

Axiom
annotated source: Medulloblastoma
annotated property: has exact synonym
annotated target: Medulloblastoma
term-group: PT
term-source: NCI

Axiom
annotated source: Medulloblastoma
annotated property: has exact synonym
annotated target: Medulloblastoma
term-group: PT
term-source: NICHD

Axiom
annotated source: Medulloblastoma
annotated property: has exact synonym
annotated target: Medulloblastoma
term-group: SY
term-source: NCI
source-code: TCGA
subsource-name: caDSR

Axiom
annotated source: Medulloblastoma
annotated property: has exact synonym
annotated target: Medulloblastomas
term-group: SY
term-source: CDISC

Axiom
annotated source: Medulloblastoma
annotated property: has exact synonym
annotated target: medulloblastoma
term-group: PT
term-source: NCI-GLOSS
source-code: CDR0000045780

Melanoma
type: Class
definition: A malignant, usually aggressive tumor composed of atypical, neoplastic melanocytes. Most often, melanomas arise in the skin (cutaneous melanomas) and include the following histologic subtypes: superficial spreading melanoma, nodular melanoma, acral lentiginous melanoma, and lentigo maligna melanoma. Cutaneous melanomas may arise from acquired or congenital melanocytic or dysplastic nevi. Melanomas may also arise in other anatomic sites including the gastrointestinal system, eye, urinary tract, and reproductive system. Melanomas frequently metastasize to lymph nodes, liver, lungs, and brain.
Has_NICHD_Parent: NCIT C3371
Has_NICHD_Parent: NCIT C9305
Concept_In_Subset: NCIT C102905
Concept_In_Subset: NCIT C103113
Concept_In_Subset: NCIT C116977
Concept_In_Subset: NCIT C118464
Concept_In_Subset: NCIT C126659
Concept_In_Subset: NCIT C61410
Concept_In_Subset: NCIT C77526
Concept_In_Subset: NCIT C88025
Concept_In_Subset: NCIT C90259
code: C3224
Semantic_Type: Neoplastic Process
Display_Name: Melanoma
Preferred_Name: Melanoma
UMLS_CUI: C0025202
Contributing_Source: CDISC
Contributing_Source: CTEP
Contributing_Source: CTRP
Contributing_Source: MedDRA
Contributing_Source: NICHD
ALT_DEFINITION: A form of cancer that begins in melanocytes (cells that make the pigment melanin). It may begin in a mole (skin melanoma), but can also begin in other pigmented tissues, such as in the eye or in the intestines.
ALT_DEFINITION: A malignant neoplasm composed of melanocytes.
ALT_DEFINITION: A malignant neoplasm comprised of melanocytes typically arising in the skin.
ICD-O-3_Code: 8720/3
Neoplastic_Status: Malignant
Legacy_Concept_Name: Melanoma
NICHD_Hierarchy_Term: Melanoma
has exact synonym: MELANOMA, MALIGNANT
has exact synonym: Malignant Melanoma
has exact synonym: Melanoma
has exact synonym: melanoma
in subset: oncotree slim

Axiom
annotated source: Melanoma
annotated property: definition
annotated target: A malignant, usually aggressive tumor composed of atypical, neoplastic melanocytes. Most often, melanomas arise in the skin (cutaneous melanomas) and include the following histologic subtypes: superficial spreading melanoma, nodular melanoma, acral lentiginous melanoma, and lentigo maligna melanoma. Cutaneous melanomas may arise from acquired or congenital melanocytic or dysplastic nevi. Melanomas may also arise in other anatomic sites including the gastrointestinal system, eye, urinary tract, and reproductive system. Melanomas frequently metastasize to lymph nodes, liver, lungs, and brain.
def-source: NCI

Axiom
annotated source: Melanoma
annotated property: ALT_DEFINITION
annotated target: A form of cancer that begins in melanocytes (cells that make the pigment melanin). It may begin in a mole (skin melanoma), but can also begin in other pigmented tissues, such as in the eye or in the intestines.
def-source: NCI-GLOSS

Axiom
annotated source: Melanoma
annotated property: ALT_DEFINITION
annotated target: A malignant neoplasm composed of melanocytes.
def-source: CDISC

Axiom
annotated source: Melanoma
annotated property: ALT_DEFINITION
annotated target: A malignant neoplasm comprised of melanocytes typically arising in the skin.
def-source: NICHD

Axiom
annotated source: Melanoma
annotated property: has exact synonym
annotated target: MELANOMA, MALIGNANT
term-group: PT
term-source: CDISC

Axiom
annotated source: Melanoma
annotated property: has exact synonym
annotated target: Malignant Melanoma
term-group: SY
term-source: CDISC

Axiom
annotated source: Melanoma
annotated property: has exact synonym
annotated target: Malignant Melanoma
term-group: SY
term-source: NCI

Axiom
annotated source: Melanoma
annotated property: has exact synonym
annotated target: Melanoma
term-group: DN
term-source: CTRP

Axiom
annotated source: Melanoma
annotated property: has exact synonym
annotated target: Melanoma
term-group: PT
term-source: CTEP
source-code: 10053571
subsource-name: SDC

Axiom
annotated source: Melanoma
annotated property: has exact synonym
annotated target: Melanoma
term-group: PT
term-source: CTRP

Axiom
annotated source: Melanoma
annotated property: has exact synonym
annotated target: Melanoma
term-group: PT
term-source: NCI

Axiom
annotated source: Melanoma
annotated property: has exact synonym
annotated target: Melanoma
term-group: PT
term-source: NICHD

Axiom
annotated source: Melanoma
annotated property: has exact synonym
annotated target: Melanoma
term-group: SY
term-source: NCI
source-code: TCGA
subsource-name: caDSR

Axiom
annotated source: Melanoma
annotated property: has exact synonym
annotated target: melanoma
term-group: PT
term-source: NCI-GLOSS
source-code: CDR0000045135

Meningeal Neoplasm
type: Class
definition: A benign or malignant neoplasm that affects the meninges. The majority of the neoplasms arise from meningothelial cells and are called meningiomas. Non-meningothelial cell neoplasms include mesenchymal, non-meningothelial tumors, hemangiopericytomas, and melanocytic lesions.
code: C3229
Semantic_Type: Neoplastic Process
Preferred_Name: Meningeal Neoplasm
UMLS_CUI: C0025284
Neoplastic_Status: Undetermined
Legacy_Concept_Name: Meningeal_Neoplasm
has exact synonym: Meningeal Neoplasm
has exact synonym: Meningeal Neoplasms
has exact synonym: Meningeal Tumor
has exact synonym: Meninges Neoplasm
has exact synonym: Meninges Tumor
has exact synonym: Neoplasm of Meninges
has exact synonym: Neoplasm of the Meninges
has exact synonym: Tumor of Meninges
has exact synonym: Tumor of the Meninges
in subset: oncotree slim

Axiom
annotated source: Meningeal Neoplasm
annotated property: definition
annotated target: A benign or malignant neoplasm that affects the meninges. The majority of the neoplasms arise from meningothelial cells and are called meningiomas. Non-meningothelial cell neoplasms include mesenchymal, non-meningothelial tumors, hemangiopericytomas, and melanocytic lesions.
def-source: NCI

Axiom
annotated source: Meningeal Neoplasm
annotated property: has exact synonym
annotated target: Meningeal Neoplasm
term-group: PT
term-source: NCI

Axiom
annotated source: Meningeal Neoplasm
annotated property: has exact synonym
annotated target: Meningeal Neoplasms
term-group: SY
term-source: NCI

Axiom
annotated source: Meningeal Neoplasm
annotated property: has exact synonym
annotated target: Meningeal Tumor
term-group: SY
term-source: NCI

Axiom
annotated source: Meningeal Neoplasm
annotated property: has exact synonym
annotated target: Meninges Neoplasm
term-group: SY
term-source: NCI

Axiom
annotated source: Meningeal Neoplasm
annotated property: has exact synonym
annotated target: Meninges Tumor
term-group: SY
term-source: NCI

Axiom
annotated source: Meningeal Neoplasm
annotated property: has exact synonym
annotated target: Neoplasm of Meninges
term-group: SY
term-source: NCI

Axiom
annotated source: Meningeal Neoplasm
annotated property: has exact synonym
annotated target: Neoplasm of the Meninges
term-group: SY
term-source: NCI

Axiom
annotated source: Meningeal Neoplasm
annotated property: has exact synonym
annotated target: Tumor of Meninges
term-group: SY
term-source: NCI

Axiom
annotated source: Meningeal Neoplasm
annotated property: has exact synonym
annotated target: Tumor of the Meninges
term-group: SY
term-source: NCI

Meningioma
type: Class
subclass of: Meningeal Neoplasm
definition: A generally slow growing tumor attached to the dura mater. It is composed of neoplastic meningothelial (arachnoidal) cells. It typically occurs in adults, often women and it has a wide range of histopathological appearances. Of the various subtypes, meningothelial, fibrous and transitional meningiomas are the most common. Most meningiomas are WHO grade I tumors, and some are WHO grade II or III tumors. Most subtypes share a common clinical behavior, although some subtypes are more likely to recur and follow a more aggressive clinical course. (Adapted from WHO)
Has_NICHD_Parent: NCIT C3268
Concept_In_Subset: NCIT C102905
Concept_In_Subset: NCIT C103049
Concept_In_Subset: NCIT C116977
Concept_In_Subset: NCIT C118464
Concept_In_Subset: NCIT C126659
Concept_In_Subset: NCIT C90259
code: C3230
Semantic_Type: Neoplastic Process
Display_Name: Meningioma
Preferred_Name: Meningioma
UMLS_CUI: C0025286
Contributing_Source: CTEP
Contributing_Source: CTRP
Contributing_Source: MedDRA
Contributing_Source: NICHD
ALT_DEFINITION: A type of slow-growing tumor that forms in the meninges (thin layers of tissue that cover and protect the brain and spinal cord). Meningiomas usually occur in adults.
ALT_DEFINITION: A usually benign tumor that develops in the meninges.
ICD-O-3_Code: 9530/0
Neoplastic_Status: Undetermined
Legacy_Concept_Name: Meningioma
NICHD_Hierarchy_Term: Meningioma
has exact synonym: Meningioma
has exact synonym: Meningioma, NOS
has exact synonym: meningioma
in subset: oncotree slim

Axiom
annotated source: Meningioma
annotated property: definition
annotated target: A generally slow growing tumor attached to the dura mater. It is composed of neoplastic meningothelial (arachnoidal) cells. It typically occurs in adults, often women and it has a wide range of histopathological appearances. Of the various subtypes, meningothelial, fibrous and transitional meningiomas are the most common. Most meningiomas are WHO grade I tumors, and some are WHO grade II or III tumors. Most subtypes share a common clinical behavior, although some subtypes are more likely to recur and follow a more aggressive clinical course. (Adapted from WHO)
def-source: NCI

Axiom
annotated source: Meningioma
annotated property: ALT_DEFINITION
annotated target: A type of slow-growing tumor that forms in the meninges (thin layers of tissue that cover and protect the brain and spinal cord). Meningiomas usually occur in adults.
def-source: NCI-GLOSS

Axiom
annotated source: Meningioma
annotated property: ALT_DEFINITION
annotated target: A usually benign tumor that develops in the meninges.
def-source: NICHD

Axiom
annotated source: Meningioma
annotated property: has exact synonym
annotated target: Meningioma
term-group: DN
term-source: CTRP

Axiom
annotated source: Meningioma
annotated property: has exact synonym
annotated target: Meningioma
term-group: PT
term-source: CTRP

Axiom
annotated source: Meningioma
annotated property: has exact synonym
annotated target: Meningioma
term-group: PT
term-source: NCI

Axiom
annotated source: Meningioma
annotated property: has exact synonym
annotated target: Meningioma
term-group: PT
term-source: NICHD

Axiom
annotated source: Meningioma
annotated property: has exact synonym
annotated target: Meningioma
term-group: SY
term-source: NCI
source-code: TCGA
subsource-name: caDSR

Axiom
annotated source: Meningioma
annotated property: has exact synonym
annotated target: Meningioma, NOS
term-group: PT
term-source: CTEP
source-code: 10027189
subsource-name: SDC

Axiom
annotated source: Meningioma
annotated property: has exact synonym
annotated target: meningioma
term-group: PT
term-source: NCI-GLOSS
source-code: CDR0000045783

Plasma Cell Myeloma
type: Class
definition: A bone marrow-based plasma cell neoplasm characterized by a serum monoclonal protein and skeletal destruction with osteolytic lesions, pathological fractures, bone pain, hypercalcemia, and anemia. Clinical variants include non-secretory myeloma, smoldering myeloma, indolent myeloma, and plasma cell leukemia. (WHO, 2001)
Concept_In_Subset: NCIT C102905
Concept_In_Subset: NCIT C103130
Concept_In_Subset: NCIT C116977
Concept_In_Subset: NCIT C126659
Concept_In_Subset: NCIT C61410
Concept_In_Subset: NCIT C77526
Concept_In_Subset: NCIT C88025
code: C3242
Semantic_Type: Neoplastic Process
Display_Name: Multiple Myeloma
Preferred_Name: Plasma Cell Myeloma
UMLS_CUI: C0026764
Contributing_Source: CDISC
Contributing_Source: CTEP
Contributing_Source: CTRP
ALT_DEFINITION: A malignant neoplasm of the bone marrow composed of plasma cells.
ALT_DEFINITION: A type of cancer that begins in plasma cells (white blood cells that produce antibodies).
ICD-O-3_Code: 9732/3
Neoplastic_Status: Malignant
Legacy_Concept_Name: Plasma_Cell_Myeloma
has exact synonym: Kahler disease
has exact synonym: MYELOMA, PLASMA CELL, MALIGNANT
has exact synonym: Multiple Myeloma
has exact synonym: Myeloma
has exact synonym: Myeloma, NOS
has exact synonym: Plasma Cell Myeloma
has exact synonym: multiple myeloma
has exact synonym: myeloma
has exact synonym: myelomatosis
has exact synonym: plasma cell myeloma
in subset: oncotree slim

Axiom
annotated source: Plasma Cell Myeloma
annotated property: definition
annotated target: A bone marrow-based plasma cell neoplasm characterized by a serum monoclonal protein and skeletal destruction with osteolytic lesions, pathological fractures, bone pain, hypercalcemia, and anemia. Clinical variants include non-secretory myeloma, smoldering myeloma, indolent myeloma, and plasma cell leukemia. (WHO, 2001)
def-source: NCI

Axiom
annotated source: Plasma Cell Myeloma
annotated property: ALT_DEFINITION
annotated target: A malignant neoplasm of the bone marrow composed of plasma cells.
def-source: CDISC

Axiom
annotated source: Plasma Cell Myeloma
annotated property: ALT_DEFINITION
annotated target: A type of cancer that begins in plasma cells (white blood cells that produce antibodies).
def-source: NCI-GLOSS

Axiom
annotated source: Plasma Cell Myeloma
annotated property: has exact synonym
annotated target: Kahler disease
term-group: PT
term-source: NCI-GLOSS
source-code: CDR0000411381

Axiom
annotated source: Plasma Cell Myeloma
annotated property: has exact synonym
annotated target: MYELOMA, PLASMA CELL, MALIGNANT
term-group: PT
term-source: CDISC

Axiom
annotated source: Plasma Cell Myeloma
annotated property: has exact synonym
annotated target: Multiple Myeloma
term-group: PT
term-source: CTRP

Axiom
annotated source: Plasma Cell Myeloma
annotated property: has exact synonym
annotated target: Multiple Myeloma
term-group: SY
term-source: CDISC

Axiom
annotated source: Plasma Cell Myeloma
annotated property: has exact synonym
annotated target: Multiple Myeloma
term-group: SY
term-source: NCI

Axiom
annotated source: Plasma Cell Myeloma
annotated property: has exact synonym
annotated target: Myeloma
term-group: SY
term-source: CDISC

Axiom
annotated source: Plasma Cell Myeloma
annotated property: has exact synonym
annotated target: Myeloma
term-group: SY
term-source: NCI

Axiom
annotated source: Plasma Cell Myeloma
annotated property: has exact synonym
annotated target: Myeloma, NOS
term-group: PT
term-source: CTEP
source-code: 10028566
subsource-name: SDC

Axiom
annotated source: Plasma Cell Myeloma
annotated property: has exact synonym
annotated target: Plasma Cell Myeloma
term-group: DN
term-source: CTRP

Axiom
annotated source: Plasma Cell Myeloma
annotated property: has exact synonym
annotated target: Plasma Cell Myeloma
term-group: PT
term-source: NCI

Axiom
annotated source: Plasma Cell Myeloma
annotated property: has exact synonym
annotated target: Plasma Cell Myeloma
term-group: SY
term-source: CTRP

Axiom
annotated source: Plasma Cell Myeloma
annotated property: has exact synonym
annotated target: Plasma Cell Myeloma
term-group: SY
term-source: NCI
source-code: TCGA
subsource-name: caDSR

Axiom
annotated source: Plasma Cell Myeloma
annotated property: has exact synonym
annotated target: multiple myeloma
term-group: PT
term-source: NCI-GLOSS
source-code: CDR0000045793

Axiom
annotated source: Plasma Cell Myeloma
annotated property: has exact synonym
annotated target: myeloma
term-group: PT
term-source: NCI-GLOSS
source-code: CDR0000045795

Axiom
annotated source: Plasma Cell Myeloma
annotated property: has exact synonym
annotated target: myelomatosis
term-group: PT
term-source: NCI-GLOSS
source-code: CDR0000411383

Axiom
annotated source: Plasma Cell Myeloma
annotated property: has exact synonym
annotated target: plasma cell myeloma
term-group: PT
term-source: NCI-GLOSS
source-code: CDR0000411384

Mycosis Fungoides
type: Class
subclass of: Primary Cutaneous T-Cell Non-Hodgkin Lymphoma
definition: A peripheral (mature) T-cell lymphoma presenting in the skin with patches/plaques. It is characterized by epidermal and dermal infiltration of small to medium-sized T-cells with cerebriform nuclei. Patients with limited disease generally have an excellent prognosis. In the more advanced stages, the prognosis is poor. (WHO, 2001)
Concept_In_Subset: NCIT C102905
Concept_In_Subset: NCIT C103133
Concept_In_Subset: NCIT C116977
Concept_In_Subset: NCIT C126659
code: C3246
Semantic_Type: Neoplastic Process
Display_Name: Mycosis Fungoides
Preferred_Name: Mycosis Fungoides
UMLS_CUI: C0026948
Contributing_Source: CTEP
Contributing_Source: CTRP
ALT_DEFINITION: A type of non-Hodgkin's lymphoma that first appears on the skin and can spread to the lymph nodes or other organs such as the spleen, liver, or lungs.
ICD-O-3_Code: 9700/3
Neoplastic_Status: Malignant
Legacy_Concept_Name: Mycosis_Fungoides
has exact synonym: CTCL/ Mycosis fungoides
has exact synonym: Cutaneous T-cell lymphoma/Mycosis fungoides
has exact synonym: MF
has exact synonym: Mycosis Fungoides
has exact synonym: mycosis fungoides
in subset: oncotree slim

Axiom
annotated source: Mycosis Fungoides
annotated property: definition
annotated target: A peripheral (mature) T-cell lymphoma presenting in the skin with patches/plaques. It is characterized by epidermal and dermal infiltration of small to medium-sized T-cells with cerebriform nuclei. Patients with limited disease generally have an excellent prognosis. In the more advanced stages, the prognosis is poor. (WHO, 2001)
def-source: NCI

Axiom
annotated source: Mycosis Fungoides
annotated property: ALT_DEFINITION
annotated target: A type of non-Hodgkin's lymphoma that first appears on the skin and can spread to the lymph nodes or other organs such as the spleen, liver, or lungs.
def-source: NCI-GLOSS

Axiom
annotated source: Mycosis Fungoides
annotated property: has exact synonym
annotated target: CTCL/ Mycosis fungoides
term-group: SY
term-source: CTEP
source-code: 10028500
subsource-name: SDC

Axiom
annotated source: Mycosis Fungoides
annotated property: has exact synonym
annotated target: Cutaneous T-cell lymphoma/Mycosis fungoides
term-group: PT
term-source: CTEP
source-code: 10028500
subsource-name: SDC

Axiom
annotated source: Mycosis Fungoides
annotated property: has exact synonym
annotated target: MF
term-group: AB
term-source: NCI

Axiom
annotated source: Mycosis Fungoides
annotated property: has exact synonym
annotated target: Mycosis Fungoides
term-group: DN
term-source: CTRP

Axiom
annotated source: Mycosis Fungoides
annotated property: has exact synonym
annotated target: Mycosis Fungoides
term-group: PT
term-source: NCI

Axiom
annotated source: Mycosis Fungoides
annotated property: has exact synonym
annotated target: Mycosis Fungoides
term-group: SY
term-source: NCI
source-code: TCGA
subsource-name: caDSR

Axiom
annotated source: Mycosis Fungoides
annotated property: has exact synonym
annotated target: mycosis fungoides
term-group: PT
term-source: NCI-GLOSS
source-code: CDR0000045794

Myelodysplastic Syndrome
type: Class
definition: A clonal hematopoietic disorder characterized by dysplasia and ineffective hematopoiesis in one or more of the hematopoietic cell lines. The dysplasia may be accompanied by an increase in myeloblasts, but the number is less than 20%, which, according to the WHO guidelines, is the requisite threshold for the diagnosis of acute myeloid leukemia. It may occur de novo or as a result of exposure to alkylating agents and/or radiotherapy. (WHO, 2001)
Has_NICHD_Parent: NCIT C3262
Concept_In_Subset: NCIT C102905
Concept_In_Subset: NCIT C103128
Concept_In_Subset: NCIT C116977
Concept_In_Subset: NCIT C118464
Concept_In_Subset: NCIT C126659
Concept_In_Subset: NCIT C90259
code: C3247
Semantic_Type: Neoplastic Process
Display_Name: Myelodysplastic Syndrome
Preferred_Name: Myelodysplastic Syndrome
UMLS_CUI: C3463824
Contributing_Source: CTEP
Contributing_Source: CTRP
Contributing_Source: MedDRA
Contributing_Source: NICHD
ALT_DEFINITION: A disorder characterized by insufficiently healthy hematapoietic cell production by the bone marrow.
ALT_DEFINITION: A group of diseases in which the bone marrow does not make enough healthy blood cells.
ALT_DEFINITION: A pre-malignant disorder characterized by blood cytopenias and abnormalities in bone marrow morphology.
ICD-O-3_Code: 9989/3
Neoplastic_Status: Undetermined
Legacy_Concept_Name: Myelodysplastic_Syndrome
NICHD_Hierarchy_Term: Myelodysplastic Syndrome
has exact synonym: Dysmyelopoietic Syndrome
has exact synonym: Hematopoeitic - Myelodysplastic Syndrome (MDS)
has exact synonym: MDS
has exact synonym: Myelodysplasia
has exact synonym: Myelodysplastic Neoplasm
has exact synonym: Myelodysplastic Syndrome
has exact synonym: Myelodysplastic Syndrome/Neoplasm
has exact synonym: Myelodysplastic syndrome
has exact synonym: Myelodysplastic syndrome, NOS
has exact synonym: Oligoblastic Leukemia
has exact synonym: Preleukemia
has exact synonym: Smoldering Leukemia
has exact synonym: myelodysplasia
has exact synonym: myelodysplastic syndromes
has exact synonym: preleukemia
has exact synonym: smoldering leukemia
in subset: oncotree slim

Axiom
annotated source: Myelodysplastic Syndrome
annotated property: definition
annotated target: A clonal hematopoietic disorder characterized by dysplasia and ineffective hematopoiesis in one or more of the hematopoietic cell lines. The dysplasia may be accompanied by an increase in myeloblasts, but the number is less than 20%, which, according to the WHO guidelines, is the requisite threshold for the diagnosis of acute myeloid leukemia. It may occur de novo or as a result of exposure to alkylating agents and/or radiotherapy. (WHO, 2001)
def-source: NCI

Axiom
annotated source: Myelodysplastic Syndrome
annotated property: ALT_DEFINITION
annotated target: A disorder characterized by insufficiently healthy hematapoietic cell production by the bone marrow.
def-source: CTCAE

Axiom
annotated source: Myelodysplastic Syndrome
annotated property: ALT_DEFINITION
annotated target: A group of diseases in which the bone marrow does not make enough healthy blood cells.
def-source: NCI-GLOSS

Axiom
annotated source: Myelodysplastic Syndrome
annotated property: ALT_DEFINITION
annotated target: A pre-malignant disorder characterized by blood cytopenias and abnormalities in bone marrow morphology.
def-source: NICHD

Axiom
annotated source: Myelodysplastic Syndrome
annotated property: has exact synonym
annotated target: Dysmyelopoietic Syndrome
term-group: SY
term-source: NCI

Axiom
annotated source: Myelodysplastic Syndrome
annotated property: has exact synonym
annotated target: Hematopoeitic - Myelodysplastic Syndrome (MDS)
term-group: SY
term-source: NCI

Axiom
annotated source: Myelodysplastic Syndrome
annotated property: has exact synonym
annotated target: MDS
term-group: AB
term-source: NCI

Axiom
annotated source: Myelodysplastic Syndrome
annotated property: has exact synonym
annotated target: Myelodysplasia
term-group: SY
term-source: NCI

Axiom
annotated source: Myelodysplastic Syndrome
annotated property: has exact synonym
annotated target: Myelodysplastic Neoplasm
term-group: SY
term-source: NCI

Axiom
annotated source: Myelodysplastic Syndrome
annotated property: has exact synonym
annotated target: Myelodysplastic Syndrome
term-group: PT
term-source: CTRP

Axiom
annotated source: Myelodysplastic Syndrome
annotated property: has exact synonym
annotated target: Myelodysplastic Syndrome
term-group: PT
term-source: NCI

Axiom
annotated source: Myelodysplastic Syndrome
annotated property: has exact synonym
annotated target: Myelodysplastic Syndrome
term-group: PT
term-source: NICHD

Axiom
annotated source: Myelodysplastic Syndrome
annotated property: has exact synonym
annotated target: Myelodysplastic Syndrome
term-group: SY
term-source: NCI
source-code: TCGA
subsource-name: caDSR

Axiom
annotated source: Myelodysplastic Syndrome
annotated property: has exact synonym
annotated target: Myelodysplastic Syndrome/Neoplasm
term-group: SY
term-source: NCI

Axiom
annotated source: Myelodysplastic Syndrome
annotated property: has exact synonym
annotated target: Myelodysplastic syndrome
term-group: PT
term-source: CTCAE
source-code: E12552

Axiom
annotated source: Myelodysplastic Syndrome
annotated property: has exact synonym
annotated target: Myelodysplastic syndrome, NOS
term-group: PT
term-source: CTEP
source-code: 10028534
subsource-name: SDC

Axiom
annotated source: Myelodysplastic Syndrome
annotated property: has exact synonym
annotated target: Oligoblastic Leukemia
term-group: SY
term-source: NCI

Axiom
annotated source: Myelodysplastic Syndrome
annotated property: has exact synonym
annotated target: Preleukemia
term-group: AQS
term-source: NCI

Axiom
annotated source: Myelodysplastic Syndrome
annotated property: has exact synonym
annotated target: Smoldering Leukemia
term-group: SY
term-source: NCI

Axiom
annotated source: Myelodysplastic Syndrome
annotated property: has exact synonym
annotated target: myelodysplasia
term-group: PT
term-source: NCI-GLOSS
source-code: CDR0000045953

Axiom
annotated source: Myelodysplastic Syndrome
annotated property: has exact synonym
annotated target: myelodysplastic syndromes
term-group: PT
term-source: NCI-GLOSS
source-code: CDR0000045266

Axiom
annotated source: Myelodysplastic Syndrome
annotated property: has exact synonym
annotated target: preleukemia
term-group: PT
term-source: NCI-GLOSS
source-code: CDR0000045480

Axiom
annotated source: Myelodysplastic Syndrome
annotated property: has exact synonym
annotated target: smoldering leukemia
term-group: PT
term-source: NCI-GLOSS
source-code: CDR0000046583

Embryonal Neoplasm
type: Class
definition: A usually malignant neoplasm composed of primitive (immature) tissues that resemble fetal tissues. Medulloblastoma, Ependymoblastoma, Pineoblastoma, and Wilms tumor are representative embryonal neoplasms. --2003
code: C3264
Semantic_Type: Neoplastic Process
Preferred_Name: Embryonal Neoplasm
UMLS_CUI: C0027654
ALT_DEFINITION: A mass of rapidly growing cells that begins in embryonic (fetal) tissue. Embryonal tumors may be benign or malignant, and include neuroblastomas and Wilms tumors.
Neoplastic_Status: Malignant
Legacy_Concept_Name: Embryonal_Neoplasm
has exact synonym: Embryonal Neoplasm
has exact synonym: embryonal tumor
in subset: oncotree slim

Axiom
annotated source: Embryonal Neoplasm
annotated property: definition
annotated target: A usually malignant neoplasm composed of primitive (immature) tissues that resemble fetal tissues. Medulloblastoma, Ependymoblastoma, Pineoblastoma, and Wilms tumor are representative embryonal neoplasms. --2003
def-source: NCI

Axiom
annotated source: Embryonal Neoplasm
annotated property: ALT_DEFINITION
annotated target: A mass of rapidly growing cells that begins in embryonic (fetal) tissue. Embryonal tumors may be benign or malignant, and include neuroblastomas and Wilms tumors.
def-source: NCI-GLOSS

Axiom
annotated source: Embryonal Neoplasm
annotated property: has exact synonym
annotated target: Embryonal Neoplasm
term-group: PT
term-source: NCI

Axiom
annotated source: Embryonal Neoplasm
annotated property: has exact synonym
annotated target: embryonal tumor
term-group: PT
term-source: NCI-GLOSS
source-code: CDR0000367442

Wilms Tumor
type: Class
subclass of: Embryonal Neoplasm
definition: An embryonal neoplasm characterized by the presence of epithelial, mesenchymal, and blastema components. The vast majority of cases arise from the kidney. A small number of cases with morphologic features resembling Wilms tumor of the kidney have been reported arising from the ovary and the cervix.
Has_NICHD_Parent: NCIT C9305
Concept_In_Subset: NCIT C102905
Concept_In_Subset: NCIT C103086
Concept_In_Subset: NCIT C116977
Concept_In_Subset: NCIT C118464
Concept_In_Subset: NCIT C123272
Concept_In_Subset: NCIT C126659
Concept_In_Subset: NCIT C90259
code: C3267
Semantic_Type: Neoplastic Process
Display_Name: Wilms Tumor
Preferred_Name: Wilms Tumor
NCI_META_CUI: CL505178
Contributing_Source: CTEP
Contributing_Source: CTRP
Contributing_Source: MedDRA
Contributing_Source: NICHD
ALT_DEFINITION: A malignant neoplasm of embryonal origin arising within the kidney.
Neoplastic_Status: Malignant
Legacy_Concept_Name: Wilms_Tumor
NICHD_Hierarchy_Term: Wilms Tumor
has exact synonym: Wilms Tumor
has exact synonym: Wilms tumor (Nephroblastoma)
has exact synonym: Wilms' Tumor
in subset: oncotree slim

Axiom
annotated source: Wilms Tumor
annotated property: definition
annotated target: An embryonal neoplasm characterized by the presence of epithelial, mesenchymal, and blastema components. The vast majority of cases arise from the kidney. A small number of cases with morphologic features resembling Wilms tumor of the kidney have been reported arising from the ovary and the cervix.
def-source: NCI

Axiom
annotated source: Wilms Tumor
annotated property: ALT_DEFINITION
annotated target: A malignant neoplasm of embryonal origin arising within the kidney.
def-source: NICHD

Axiom
annotated source: Wilms Tumor
annotated property: has exact synonym
annotated target: Wilms Tumor
term-group: PT
term-source: CTRP

Axiom
annotated source: Wilms Tumor
annotated property: has exact synonym
annotated target: Wilms Tumor
term-group: PT
term-source: NCI

Axiom
annotated source: Wilms Tumor
annotated property: has exact synonym
annotated target: Wilms Tumor
term-group: PT
term-source: NICHD

Axiom
annotated source: Wilms Tumor
annotated property: has exact synonym
annotated target: Wilms tumor (Nephroblastoma)
term-group: PT
term-source: CTEP
source-code: 10029145
subsource-name: SDC

Axiom
annotated source: Wilms Tumor
annotated property: has exact synonym
annotated target: Wilms' Tumor
term-group: SY
term-source: NCI

Schwannoma
type: Class
subclass of: Nerve Sheath Neoplasm
definition: A benign, usually encapsulated slow growing tumor composed of Schwann cells. It affects peripheral and cranial nerves. It recurs infrequently and only rare cases associated with malignant transformation have been reported.
Concept_In_Subset: NCIT C126659
Concept_In_Subset: NCIT C61410
Concept_In_Subset: NCIT C77526
Concept_In_Subset: NCIT C88025
code: C3269
Semantic_Type: Neoplastic Process
Preferred_Name: Schwannoma
UMLS_CUI: C0027809
Contributing_Source: CDISC
ALT_DEFINITION: A benign neoplasm of the peripheral nervous system composed of well-differentiated Schwann cells.
ALT_DEFINITION: A tumor of the peripheral nervous system that arises in the nerve sheath (protective covering). It is almost always benign, but rare malignant schwannomas have been reported.
ICD-O-3_Code: 9560/0
Neoplastic_Status: Benign
Legacy_Concept_Name: Schwannoma
has exact synonym: Benign Neurilemmoma
has exact synonym: Benign Schwannoma
has exact synonym: Neurilemmoma
has exact synonym: Neurinoma
has exact synonym: SCHWANNOMA, BENIGN
has exact synonym: Schwannoma
has exact synonym: Schwannoma (WHO Grade I)
has exact synonym: Schwannoma (Who Grade I)
has exact synonym: schwannoma
in subset: oncotree slim

Axiom
annotated source: Schwannoma
annotated property: definition
annotated target: A benign, usually encapsulated slow growing tumor composed of Schwann cells. It affects peripheral and cranial nerves. It recurs infrequently and only rare cases associated with malignant transformation have been reported.
def-source: NCI

Axiom
annotated source: Schwannoma
annotated property: ALT_DEFINITION
annotated target: A benign neoplasm of the peripheral nervous system composed of well-differentiated Schwann cells.
def-source: CDISC

Axiom
annotated source: Schwannoma
annotated property: ALT_DEFINITION
annotated target: A tumor of the peripheral nervous system that arises in the nerve sheath (protective covering). It is almost always benign, but rare malignant schwannomas have been reported.
def-source: NCI-GLOSS

Axiom
annotated source: Schwannoma
annotated property: has exact synonym
annotated target: Benign Neurilemmoma
term-group: SY
term-source: NCI

Axiom
annotated source: Schwannoma
annotated property: has exact synonym
annotated target: Benign Schwannoma
term-group: SY
term-source: NCI

Axiom
annotated source: Schwannoma
annotated property: has exact synonym
annotated target: Neurilemmoma
term-group: SY
term-source: CDISC

Axiom
annotated source: Schwannoma
annotated property: has exact synonym
annotated target: Neurilemmoma
term-group: SY
term-source: NCI

Axiom
annotated source: Schwannoma
annotated property: has exact synonym
annotated target: Neurinoma
term-group: AQS
term-source: NCI

Axiom
annotated source: Schwannoma
annotated property: has exact synonym
annotated target: Neurinoma
term-group: SY
term-source: CDISC

Axiom
annotated source: Schwannoma
annotated property: has exact synonym
annotated target: SCHWANNOMA, BENIGN
term-group: PT
term-source: CDISC

Axiom
annotated source: Schwannoma
annotated property: has exact synonym
annotated target: Schwannoma
term-group: PT
term-source: NCI

Axiom
annotated source: Schwannoma
annotated property: has exact synonym
annotated target: Schwannoma
term-group: SY
term-source: CDISC

Axiom
annotated source: Schwannoma
annotated property: has exact synonym
annotated target: Schwannoma
term-group: SY
term-source: NCI
source-code: TCGA
subsource-name: caDSR

Axiom
annotated source: Schwannoma
annotated property: has exact synonym
annotated target: Schwannoma (WHO Grade I)
term-group: SY
term-source: NCI

Axiom
annotated source: Schwannoma
annotated property: has exact synonym
annotated target: Schwannoma (Who Grade I)
term-group: SY
term-source: CDISC

Axiom
annotated source: Schwannoma
annotated property: has exact synonym
annotated target: schwannoma
term-group: PT
term-source: NCI-GLOSS
source-code: CDR0000046572

Neuroblastoma
type: Class
definition: A neuroblastic tumor characterized by the presence of neuroblastic cells, the absence of ganglion cells, and the absence of a prominent Schwannian stroma formation.
Has_NICHD_Parent: NCIT C3268
Concept_In_Subset: NCIT C102905
Concept_In_Subset: NCIT C103053
Concept_In_Subset: NCIT C116977
Concept_In_Subset: NCIT C118464
Concept_In_Subset: NCIT C126659
Concept_In_Subset: NCIT C61410
Concept_In_Subset: NCIT C77526
Concept_In_Subset: NCIT C88025
Concept_In_Subset: NCIT C90259
Concept_In_Subset: NCIT C99147
code: C3270
Semantic_Type: Neoplastic Process
Display_Name: Neuroblastoma
Preferred_Name: Neuroblastoma
UMLS_CUI: C0027819
Contributing_Source: CDISC
Contributing_Source: CTEP
Contributing_Source: CTRP
Contributing_Source: MedDRA
Contributing_Source: NICHD
ALT_DEFINITION: A malignant neoplasm composed of neuroblastic cells.
ALT_DEFINITION: A malignant neoplasm comprised of neuroblasts that commonly arises in or near the adrenal glands.
ALT_DEFINITION: Cancer that arises in immature nerve cells and affects mostly infants and children.
ICD-O-3_Code: 9500/3
Neoplastic_Status: Malignant
Legacy_Concept_Name: Neuroblastoma
NICHD_Hierarchy_Term: Neuroblastoma
has exact synonym: NEUROBLASTOMA, MALIGNANT
has exact synonym: Neural Crest Tumor, Malignant
has exact synonym: Neuroblastoma
has exact synonym: Neuroblastoma (Schwannian Stroma-Poor)
has exact synonym: Neuroblastoma (Schwannian Stroma-poor)
has exact synonym: neuroblastoma
in subset: oncotree slim

Axiom
annotated source: Neuroblastoma
annotated property: definition
annotated target: A neuroblastic tumor characterized by the presence of neuroblastic cells, the absence of ganglion cells, and the absence of a prominent Schwannian stroma formation.
def-source: NCI

Axiom
annotated source: Neuroblastoma
annotated property: ALT_DEFINITION
annotated target: A malignant neoplasm composed of neuroblastic cells.
def-source: CDISC

Axiom
annotated source: Neuroblastoma
annotated property: ALT_DEFINITION
annotated target: A malignant neoplasm comprised of neuroblasts that commonly arises in or near the adrenal glands.
def-source: NICHD

Axiom
annotated source: Neuroblastoma
annotated property: ALT_DEFINITION
annotated target: Cancer that arises in immature nerve cells and affects mostly infants and children.
def-source: NCI-GLOSS

Axiom
annotated source: Neuroblastoma
annotated property: has exact synonym
annotated target: NEUROBLASTOMA, MALIGNANT
term-group: PT
term-source: CDISC

Axiom
annotated source: Neuroblastoma
annotated property: has exact synonym
annotated target: Neural Crest Tumor, Malignant
term-group: SY
term-source: CDISC

Axiom
annotated source: Neuroblastoma
annotated property: has exact synonym
annotated target: Neuroblastoma
term-group: DN
term-source: CTRP

Axiom
annotated source: Neuroblastoma
annotated property: has exact synonym
annotated target: Neuroblastoma
term-group: PT
term-source: CTEP
source-code: 10029261
subsource-name: SDC

Axiom
annotated source: Neuroblastoma
annotated property: has exact synonym
annotated target: Neuroblastoma
term-group: PT
term-source: CTRP

Axiom
annotated source: Neuroblastoma
annotated property: has exact synonym
annotated target: Neuroblastoma
term-group: PT
term-source: NCI

Axiom
annotated source: Neuroblastoma
annotated property: has exact synonym
annotated target: Neuroblastoma
term-group: PT
term-source: NICHD

Axiom
annotated source: Neuroblastoma
annotated property: has exact synonym
annotated target: Neuroblastoma
term-group: SY
term-source: NCI
source-code: TCGA
subsource-name: caDSR

Axiom
annotated source: Neuroblastoma
annotated property: has exact synonym
annotated target: Neuroblastoma (Schwannian Stroma-Poor)
term-group: SY
term-source: NCI

Axiom
annotated source: Neuroblastoma
annotated property: has exact synonym
annotated target: Neuroblastoma (Schwannian Stroma-poor)
term-group: SY
term-source: CDISC

Axiom
annotated source: Neuroblastoma
annotated property: has exact synonym
annotated target: neuroblastoma
term-group: PT
term-source: NCI-GLOSS
source-code: CDR0000045418

Neurofibroma
type: Class
subclass of: Nerve Sheath Neoplasm
definition: An intraneural or extraneural neoplasm arising from nerve tissues and neural sheaths. It is composed of perineurial-like fibroblasts and Schwann cells. It usually presents as a localized cutaneous lesion and less often as a circumscribed peripheral nerve mass. Patients with neurofibromatosis type 1 present with multiple masses. Neurofibromas which arise from major nerves and plexiform neurofibromas are precursor lesions to malignant peripheral nerve sheath tumors.
Concept_In_Subset: NCIT C126659
Concept_In_Subset: NCIT C61410
Concept_In_Subset: NCIT C77526
Concept_In_Subset: NCIT C88025
code: C3272
Semantic_Type: Neoplastic Process
Preferred_Name: Neurofibroma
UMLS_CUI: C0027830
Contributing_Source: CDISC
ALT_DEFINITION: A benign tumor that develops from the cells and tissues that cover nerves.
ALT_DEFINITION: An intraneural or extraneural neoplasm arising from nerve tissues and neural sheaths, composed of perineurial-like fibroblasts and Schwann cells.
ICD-O-3_Code: 9540/0
Neoplastic_Status: Benign
Legacy_Concept_Name: Neurofibroma
has exact synonym: NEUROFIBROMA, BENIGN
has exact synonym: Neurofibroma
has exact synonym: Neurofibroma (WHO Grade I)
has exact synonym: neurofibroma
in subset: oncotree slim

Axiom
annotated source: Neurofibroma
annotated property: definition
annotated target: An intraneural or extraneural neoplasm arising from nerve tissues and neural sheaths. It is composed of perineurial-like fibroblasts and Schwann cells. It usually presents as a localized cutaneous lesion and less often as a circumscribed peripheral nerve mass. Patients with neurofibromatosis type 1 present with multiple masses. Neurofibromas which arise from major nerves and plexiform neurofibromas are precursor lesions to malignant peripheral nerve sheath tumors.
def-source: NCI

Axiom
annotated source: Neurofibroma
annotated property: ALT_DEFINITION
annotated target: A benign tumor that develops from the cells and tissues that cover nerves.
def-source: NCI-GLOSS

Axiom
annotated source: Neurofibroma
annotated property: ALT_DEFINITION
annotated target: An intraneural or extraneural neoplasm arising from nerve tissues and neural sheaths, composed of perineurial-like fibroblasts and Schwann cells.
def-source: CDISC

Axiom
annotated source: Neurofibroma
annotated property: has exact synonym
annotated target: NEUROFIBROMA, BENIGN
term-group: PT
term-source: CDISC

Axiom
annotated source: Neurofibroma
annotated property: has exact synonym
annotated target: Neurofibroma
term-group: PT
term-source: NCI

Axiom
annotated source: Neurofibroma
annotated property: has exact synonym
annotated target: Neurofibroma
term-group: SY
term-source: NCI
source-code: TCGA
subsource-name: caDSR

Axiom
annotated source: Neurofibroma
annotated property: has exact synonym
annotated target: Neurofibroma (WHO Grade I)
term-group: SY
term-source: NCI

Axiom
annotated source: Neurofibroma
annotated property: has exact synonym
annotated target: neurofibroma
term-group: PT
term-source: NCI-GLOSS
source-code: CDR0000045095

Oligodendroglioma
type: Class
definition: A well-differentiated (WHO grade II), diffusely infiltrating neuroglial tumor, typically located in the cerebral hemispheres. It is composed predominantly of cells which morphologically resemble oligodendroglia. The neoplastic cells have rounded homogeneous nuclei and, on paraffin sections, a swollen, clear cytoplasm ('honeycomb' appearance). (Adapted from WHO)
Concept_In_Subset: NCIT C102905
Concept_In_Subset: NCIT C103050
Concept_In_Subset: NCIT C126659
code: C3288
Semantic_Type: Neoplastic Process
Display_Name: Oligodendroglioma
Preferred_Name: Oligodendroglioma
UMLS_CUI: C0751396
Contributing_Source: CTEP
ALT_DEFINITION: A rare, slow-growing tumor that begins in oligodendrocytes (cells that cover and protect nerve cells in the brain and spinal cord).
ICD-O-3_Code: 9450/3
Neoplastic_Status: Undetermined
Legacy_Concept_Name: Oligodendroglioma
has exact synonym: Oligodendroglioma
has exact synonym: Oligodendroglioma, NOS
has exact synonym: WHO Grade II Oligodendroglial Neoplasm
has exact synonym: WHO Grade II Oligodendroglial Tumor
has exact synonym: Well Differentiated Oligodendroglial Tumor
has exact synonym: Well Differentiated Oligodendroglioma
has exact synonym: oligodendroglioma
in subset: oncotree slim

Axiom
annotated source: Oligodendroglioma
annotated property: definition
annotated target: A well-differentiated (WHO grade II), diffusely infiltrating neuroglial tumor, typically located in the cerebral hemispheres. It is composed predominantly of cells which morphologically resemble oligodendroglia. The neoplastic cells have rounded homogeneous nuclei and, on paraffin sections, a swollen, clear cytoplasm ('honeycomb' appearance). (Adapted from WHO)
def-source: NCI

Axiom
annotated source: Oligodendroglioma
annotated property: ALT_DEFINITION
annotated target: A rare, slow-growing tumor that begins in oligodendrocytes (cells that cover and protect nerve cells in the brain and spinal cord).
def-source: NCI-GLOSS

Axiom
annotated source: Oligodendroglioma
annotated property: has exact synonym
annotated target: Oligodendroglioma
term-group: PT
term-source: NCI

Axiom
annotated source: Oligodendroglioma
annotated property: has exact synonym
annotated target: Oligodendroglioma
term-group: SY
term-source: NCI
source-code: TCGA
subsource-name: caDSR

Axiom
annotated source: Oligodendroglioma
annotated property: has exact synonym
annotated target: Oligodendroglioma, NOS
term-group: PT
term-source: CTEP
source-code: 10030286
subsource-name: SDC

Axiom
annotated source: Oligodendroglioma
annotated property: has exact synonym
annotated target: WHO Grade II Oligodendroglial Neoplasm
term-group: SY
term-source: NCI

Axiom
annotated source: Oligodendroglioma
annotated property: has exact synonym
annotated target: WHO Grade II Oligodendroglial Tumor
term-group: SY
term-source: NCI

Axiom
annotated source: Oligodendroglioma
annotated property: has exact synonym
annotated target: Well Differentiated Oligodendroglial Tumor
term-group: SY
term-source: NCI

Axiom
annotated source: Oligodendroglioma
annotated property: has exact synonym
annotated target: Well Differentiated Oligodendroglioma
term-group: SY
term-source: NCI

Axiom
annotated source: Oligodendroglioma
annotated property: has exact synonym
annotated target: oligodendroglioma
term-group: PT
term-source: NCI-GLOSS
source-code: CDR0000046257

Paget Disease of the Nipple
type: Class
definition: A malignant epithelial cellular proliferation characterized by the presence of atypical cells with large nuclei and abundant pale cytoplasm within the squamous epithelium of the nipple. In almost all cases there is an underlying intraductal breast carcinoma or intraductal and invasive carcinoma. The skin changes range from redness to eczematous appearance.
code: C3301
Semantic_Type: Neoplastic Process
Preferred_Name: Paget Disease of the Nipple
UMLS_CUI: C1704323
ALT_DEFINITION: A form of breast cancer in which the tumor grows from ducts beneath the nipple onto the surface of the nipple. Symptoms commonly include itching and burning and an eczema-like condition around the nipple, sometimes accompanied by oozing or bleeding.
Neoplastic_Status: Malignant
Legacy_Concept_Name: Paget_s_Disease_of_the_Nipple
has exact synonym: Nipple Paget's Disease
has exact synonym: Paget Disease of the Nipple
has exact synonym: Paget's Disease of Nipple
has exact synonym: Paget's Disease of the Nipple
has exact synonym: Paget's disease of the nipple
in subset: oncotree slim

Axiom
annotated source: Paget Disease of the Nipple
annotated property: definition
annotated target: A malignant epithelial cellular proliferation characterized by the presence of atypical cells with large nuclei and abundant pale cytoplasm within the squamous epithelium of the nipple. In almost all cases there is an underlying intraductal breast carcinoma or intraductal and invasive carcinoma. The skin changes range from redness to eczematous appearance.
def-source: NCI

Axiom
annotated source: Paget Disease of the Nipple
annotated property: ALT_DEFINITION
annotated target: A form of breast cancer in which the tumor grows from ducts beneath the nipple onto the surface of the nipple. Symptoms commonly include itching and burning and an eczema-like condition around the nipple, sometimes accompanied by oozing or bleeding.
def-source: NCI-GLOSS

Axiom
annotated source: Paget Disease of the Nipple
annotated property: has exact synonym
annotated target: Nipple Paget's Disease
term-group: SY
term-source: NCI

Axiom
annotated source: Paget Disease of the Nipple
annotated property: has exact synonym
annotated target: Paget Disease of the Nipple
term-group: PT
term-source: NCI

Axiom
annotated source: Paget Disease of the Nipple
annotated property: has exact synonym
annotated target: Paget's Disease of Nipple
term-group: SY
term-source: NCI

Axiom
annotated source: Paget Disease of the Nipple
annotated property: has exact synonym
annotated target: Paget's Disease of the Nipple
term-group: SY
term-source: NCI

Axiom
annotated source: Paget Disease of the Nipple
annotated property: has exact synonym
annotated target: Paget's disease of the nipple
term-group: PT
term-source: NCI-GLOSS
source-code: CDR0000045814

Paraganglioma
type: Class
definition: A benign or malignant neoplasm arising from paraganglia located along the sympathetic or parasympathetic nerves. Infrequently, it may arise outside the usual distribution of the sympathetic and parasympathetic paraganglia. Tumors arising from the adrenal gland medulla are called pheochromocytomas. Morphologically, paragangliomas usually display a nesting (Zellballen) growth pattern. There are no reliable morphologic criteria to distinguish between benign and malignant paragangliomas. The only definitive indicator of malignancy is the presence of regional or distant metastases.
Concept_In_Subset: NCIT C116977
Concept_In_Subset: NCIT C126659
code: C3308
Semantic_Type: Neoplastic Process
Display_Name: Paraganglioma
Preferred_Name: Paraganglioma
UMLS_CUI: C0030421
Contributing_Source: CTRP
ALT_DEFINITION: A rare, usually benign tumor that develops from cells of the paraganglia. Paraganglia are a collection of cells that came from embryonic nervous tissue, and are found near the adrenal glands and some blood vessels and nerves. Paragangliomas that develop in the adrenal gland are called pheochromocytomas. Those that develop outside of the adrenal glands near blood vessels or nerves are called glomus tumors or chemodectomas.
ICD-O-3_Code: 8680/1
Neoplastic_Status: Undetermined
Legacy_Concept_Name: Paraganglionic_Neoplasm
has exact synonym: Neoplasm of Paraganglion
has exact synonym: Neoplasm of the Paraganglion
has exact synonym: Paraganglioma
has exact synonym: Paraganglion Neoplasm
has exact synonym: Paraganglion Tumor
has exact synonym: Paraganglionic Neoplasm
has exact synonym: Paraganglionic Tumor
has exact synonym: Tumor of Paraganglion
has exact synonym: Tumor of the Paraganglion
has exact synonym: paraganglioma
in subset: oncotree slim

Axiom
annotated source: Paraganglioma
annotated property: definition
annotated target: A benign or malignant neoplasm arising from paraganglia located along the sympathetic or parasympathetic nerves. Infrequently, it may arise outside the usual distribution of the sympathetic and parasympathetic paraganglia. Tumors arising from the adrenal gland medulla are called pheochromocytomas. Morphologically, paragangliomas usually display a nesting (Zellballen) growth pattern. There are no reliable morphologic criteria to distinguish between benign and malignant paragangliomas. The only definitive indicator of malignancy is the presence of regional or distant metastases.
def-source: NCI

Axiom
annotated source: Paraganglioma
annotated property: ALT_DEFINITION
annotated target: A rare, usually benign tumor that develops from cells of the paraganglia. Paraganglia are a collection of cells that came from embryonic nervous tissue, and are found near the adrenal glands and some blood vessels and nerves. Paragangliomas that develop in the adrenal gland are called pheochromocytomas. Those that develop outside of the adrenal glands near blood vessels or nerves are called glomus tumors or chemodectomas.
def-source: NCI-GLOSS

Axiom
annotated source: Paraganglioma
annotated property: has exact synonym
annotated target: Neoplasm of Paraganglion
term-group: SY
term-source: NCI

Axiom
annotated source: Paraganglioma
annotated property: has exact synonym
annotated target: Neoplasm of the Paraganglion
term-group: SY
term-source: NCI

Axiom
annotated source: Paraganglioma
annotated property: has exact synonym
annotated target: Paraganglioma
term-group: PT
term-source: NCI

Axiom
annotated source: Paraganglioma
annotated property: has exact synonym
annotated target: Paraganglioma
term-group: SY
term-source: NCI
source-code: TCGA
subsource-name: caDSR

Axiom
annotated source: Paraganglioma
annotated property: has exact synonym
annotated target: Paraganglion Neoplasm
term-group: SY
term-source: NCI

Axiom
annotated source: Paraganglioma
annotated property: has exact synonym
annotated target: Paraganglion Tumor
term-group: SY
term-source: NCI

Axiom
annotated source: Paraganglioma
annotated property: has exact synonym
annotated target: Paraganglionic Neoplasm
term-group: SY
term-source: NCI

Axiom
annotated source: Paraganglioma
annotated property: has exact synonym
annotated target: Paraganglionic Tumor
term-group: SY
term-source: NCI

Axiom
annotated source: Paraganglioma
annotated property: has exact synonym
annotated target: Tumor of Paraganglion
term-group: SY
term-source: NCI

Axiom
annotated source: Paraganglioma
annotated property: has exact synonym
annotated target: Tumor of the Paraganglion
term-group: SY
term-source: NCI

Axiom
annotated source: Paraganglioma
annotated property: has exact synonym
annotated target: paraganglioma
term-group: PT
term-source: NCI-GLOSS
source-code: CDR0000390305

Adrenal Gland Pheochromocytoma
type: Class
definition: A benign or malignant neuroendocrine neoplasm of the sympathetic nervous system that secretes catecholamines. It arises from the chromaffin cells of the adrenal medulla. Clinical presentation includes headaches, palpitations, chest and abdominal pain, hypertension, fever, and tremor. Microscopically, a characteristic nesting (zellballen) growth pattern is usually seen. Other growth patterns including trabecular pattern may also be present.
Concept_In_Subset: NCIT C102905
Concept_In_Subset: NCIT C103057
Concept_In_Subset: NCIT C116977
Concept_In_Subset: NCIT C126659
code: C3326
Semantic_Type: Neoplastic Process
Display_Name: Pheochromocytoma
Preferred_Name: Adrenal Gland Pheochromocytoma
UMLS_CUI: C0031511
Contributing_Source: CTEP
Contributing_Source: CTRP
ALT_DEFINITION: Tumor that forms in the center of the adrenal gland (gland located above the kidney) that causes it to make too much adrenaline. Pheochromocytomas are usually benign (not cancer) but can cause high blood pressure, pounding headaches, heart palpitations, flushing of the face, nausea, and vomiting.
ICD-O-3_Code: 8700/0
Neoplastic_Status: Undetermined
Legacy_Concept_Name: Pheochromocytoma
has exact synonym: Adrenal Gland Chromaffin Paraganglioma
has exact synonym: Adrenal Gland Chromaffinoma
has exact synonym: Adrenal Gland Paraganglioma
has exact synonym: Adrenal Gland Pheochromocytoma
has exact synonym: Adrenal Medullary Paraganglioma
has exact synonym: Adrenal Medullary Pheochromocytoma
has exact synonym: Adrenal Pheochromocytoma
has exact synonym: Chromaffin Paraganglioma of the Adrenal Gland
has exact synonym: Intraadrenal Paraganglioma
has exact synonym: PCC
has exact synonym: Pheochromocytoma
has exact synonym: Pheochromocytoma (adrenal)
has exact synonym: pheochromocytoma
in subset: oncotree slim

Axiom
annotated source: Adrenal Gland Pheochromocytoma
annotated property: definition
annotated target: A benign or malignant neuroendocrine neoplasm of the sympathetic nervous system that secretes catecholamines. It arises from the chromaffin cells of the adrenal medulla. Clinical presentation includes headaches, palpitations, chest and abdominal pain, hypertension, fever, and tremor. Microscopically, a characteristic nesting (zellballen) growth pattern is usually seen. Other growth patterns including trabecular pattern may also be present.
def-source: NCI

Axiom
annotated source: Adrenal Gland Pheochromocytoma
annotated property: ALT_DEFINITION
annotated target: Tumor that forms in the center of the adrenal gland (gland located above the kidney) that causes it to make too much adrenaline. Pheochromocytomas are usually benign (not cancer) but can cause high blood pressure, pounding headaches, heart palpitations, flushing of the face, nausea, and vomiting.
def-source: NCI-GLOSS

Axiom
annotated source: Adrenal Gland Pheochromocytoma
annotated property: has exact synonym
annotated target: Adrenal Gland Chromaffin Paraganglioma
term-group: SY
term-source: NCI

Axiom
annotated source: Adrenal Gland Pheochromocytoma
annotated property: has exact synonym
annotated target: Adrenal Gland Chromaffinoma
term-group: SY
term-source: NCI

Axiom
annotated source: Adrenal Gland Pheochromocytoma
annotated property: has exact synonym
annotated target: Adrenal Gland Paraganglioma
term-group: SY
term-source: NCI

Axiom
annotated source: Adrenal Gland Pheochromocytoma
annotated property: has exact synonym
annotated target: Adrenal Gland Pheochromocytoma
term-group: PT
term-source: NCI

Axiom
annotated source: Adrenal Gland Pheochromocytoma
annotated property: has exact synonym
annotated target: Adrenal Gland Pheochromocytoma
term-group: SY
term-source: NCI
source-code: TCGA
subsource-name: caDSR

Axiom
annotated source: Adrenal Gland Pheochromocytoma
annotated property: has exact synonym
annotated target: Adrenal Medullary Paraganglioma
term-group: SY
term-source: NCI

Axiom
annotated source: Adrenal Gland Pheochromocytoma
annotated property: has exact synonym
annotated target: Adrenal Medullary Pheochromocytoma
term-group: SY
term-source: NCI

Axiom
annotated source: Adrenal Gland Pheochromocytoma
annotated property: has exact synonym
annotated target: Adrenal Pheochromocytoma
term-group: SY
term-source: NCI

Axiom
annotated source: Adrenal Gland Pheochromocytoma
annotated property: has exact synonym
annotated target: Chromaffin Paraganglioma of the Adrenal Gland
term-group: SY
term-source: NCI

Axiom
annotated source: Adrenal Gland Pheochromocytoma
annotated property: has exact synonym
annotated target: Intraadrenal Paraganglioma
term-group: SY
term-source: NCI

Axiom
annotated source: Adrenal Gland Pheochromocytoma
annotated property: has exact synonym
annotated target: PCC
term-group: AB
term-source: NCI

Axiom
annotated source: Adrenal Gland Pheochromocytoma
annotated property: has exact synonym
annotated target: Pheochromocytoma
term-group: SY
term-source: NCI

Axiom
annotated source: Adrenal Gland Pheochromocytoma
annotated property: has exact synonym
annotated target: Pheochromocytoma (adrenal)
term-group: PT
term-source: CTEP
source-code: 10034876
subsource-name: SDC

Axiom
annotated source: Adrenal Gland Pheochromocytoma
annotated property: has exact synonym
annotated target: pheochromocytoma
term-group: PT
term-source: NCI-GLOSS
source-code: CDR0000322877

Pineal Region Neoplasm
type: Class
definition: Neoplasms that are located in the pineal gland. These neoplasms arise either from pineal parenchymal cells (pineocytes), as do pineocytomas and the more aggressive pineoblastomas, or from other cell types, as do pineal astrocytic tumors (notably pilocytic astrocytomas) and germ cell tumors. Clinical symptoms include neuro-ophthalmologic dysfunction, changes in mental status, dysfunction of the brain stem, and hypothalamic-based endocrine abnormalities.
Has_NICHD_Parent: NCIT C2934
Concept_In_Subset: NCIT C118467
Concept_In_Subset: NCIT C90259
code: C3328
Semantic_Type: Neoplastic Process
Preferred_Name: Pineal Region Neoplasm
UMLS_CUI: C1412004
Contributing_Source: NICHD
ALT_DEFINITION: A tumor arising in the pineal region, the majority of which are malignant germ cell tumors. A minority of pinealomas are benign, and comprise neoplastic cells that resemble normal pineocytes.
ALT_DEFINITION: A type of brain tumor that occurs in or around the pineal gland, a tiny organ near the center of the brain.
Neoplastic_Status: Undetermined
Legacy_Concept_Name: Pineal_Region_Neoplasm
NICHD_Hierarchy_Term: Pinealoma
has exact synonym: Neoplasm of Pineal Area
has exact synonym: Neoplasm of Pineal Region
has exact synonym: Neoplasm of the Pineal Area
has exact synonym: Neoplasm of the Pineal Region
has exact synonym: Pineal Area Neoplasm
has exact synonym: Pineal Area Tumor
has exact synonym: Pineal Body Neoplasm
has exact synonym: Pineal Body Tumor
has exact synonym: Pineal Neoplasm
has exact synonym: Pineal Region Neoplasm
has exact synonym: Pineal Region Tumor
has exact synonym: Pineal Tumor
has exact synonym: Pinealoma
has exact synonym: Tumor of Pineal Area
has exact synonym: Tumor of Pineal Region
has exact synonym: Tumor of the Pineal Area
has exact synonym: Tumor of the Pineal Region
has exact synonym: pineal region tumor
in subset: oncotree slim

Axiom
annotated source: Pineal Region Neoplasm
annotated property: definition
annotated target: Neoplasms that are located in the pineal gland. These neoplasms arise either from pineal parenchymal cells (pineocytes), as do pineocytomas and the more aggressive pineoblastomas, or from other cell types, as do pineal astrocytic tumors (notably pilocytic astrocytomas) and germ cell tumors. Clinical symptoms include neuro-ophthalmologic dysfunction, changes in mental status, dysfunction of the brain stem, and hypothalamic-based endocrine abnormalities.
def-source: NCI

Axiom
annotated source: Pineal Region Neoplasm
annotated property: ALT_DEFINITION
annotated target: A tumor arising in the pineal region, the majority of which are malignant germ cell tumors. A minority of pinealomas are benign, and comprise neoplastic cells that resemble normal pineocytes.
def-source: NICHD

Axiom
annotated source: Pineal Region Neoplasm
annotated property: ALT_DEFINITION
annotated target: A type of brain tumor that occurs in or around the pineal gland, a tiny organ near the center of the brain.
def-source: NCI-GLOSS

Axiom
annotated source: Pineal Region Neoplasm
annotated property: has exact synonym
annotated target: Neoplasm of Pineal Area
term-group: SY
term-source: NCI

Axiom
annotated source: Pineal Region Neoplasm
annotated property: has exact synonym
annotated target: Neoplasm of Pineal Region
term-group: SY
term-source: NCI

Axiom
annotated source: Pineal Region Neoplasm
annotated property: has exact synonym
annotated target: Neoplasm of the Pineal Area
term-group: SY
term-source: NCI

Axiom
annotated source: Pineal Region Neoplasm
annotated property: has exact synonym
annotated target: Neoplasm of the Pineal Region
term-group: SY
term-source: NCI

Axiom
annotated source: Pineal Region Neoplasm
annotated property: has exact synonym
annotated target: Pineal Area Neoplasm
term-group: SY
term-source: NCI

Axiom
annotated source: Pineal Region Neoplasm
annotated property: has exact synonym
annotated target: Pineal Area Tumor
term-group: SY
term-source: NCI

Axiom
annotated source: Pineal Region Neoplasm
annotated property: has exact synonym
annotated target: Pineal Body Neoplasm
term-group: SY
term-source: NCI

Axiom
annotated source: Pineal Region Neoplasm
annotated property: has exact synonym
annotated target: Pineal Body Tumor
term-group: SY
term-source: NCI

Axiom
annotated source: Pineal Region Neoplasm
annotated property: has exact synonym
annotated target: Pineal Neoplasm
term-group: SY
term-source: NCI

Axiom
annotated source: Pineal Region Neoplasm
annotated property: has exact synonym
annotated target: Pineal Region Neoplasm
term-group: PT
term-source: NCI

Axiom
annotated source: Pineal Region Neoplasm
annotated property: has exact synonym
annotated target: Pineal Region Tumor
term-group: SY
term-source: NCI

Axiom
annotated source: Pineal Region Neoplasm
annotated property: has exact synonym
annotated target: Pineal Region Tumor
term-group: SY
term-source: NICHD

Axiom
annotated source: Pineal Region Neoplasm
annotated property: has exact synonym
annotated target: Pineal Tumor
term-group: SY
term-source: NCI

Axiom
annotated source: Pineal Region Neoplasm
annotated property: has exact synonym
annotated target: Pinealoma
term-group: PT
term-source: NICHD

Axiom
annotated source: Pineal Region Neoplasm
annotated property: has exact synonym
annotated target: Pinealoma
term-group: SY
term-source: NCI

Axiom
annotated source: Pineal Region Neoplasm
annotated property: has exact synonym
annotated target: Tumor of Pineal Area
term-group: SY
term-source: NCI

Axiom
annotated source: Pineal Region Neoplasm
annotated property: has exact synonym
annotated target: Tumor of Pineal Region
term-group: SY
term-source: NCI

Axiom
annotated source: Pineal Region Neoplasm
annotated property: has exact synonym
annotated target: Tumor of the Pineal Area
term-group: SY
term-source: NCI

Axiom
annotated source: Pineal Region Neoplasm
annotated property: has exact synonym
annotated target: Tumor of the Pineal Region
term-group: SY
term-source: NCI

Axiom
annotated source: Pineal Region Neoplasm
annotated property: has exact synonym
annotated target: pineal region tumor
term-group: PT
term-source: NCI-GLOSS
source-code: CDR0000046675

Pituitary Gland Adenoma
type: Class
definition: A non-metastasizing tumor that arises from the adenohypophysial cells of the anterior lobe of the pituitary gland. The tumor can be hormonally functioning or not. The diagnosis can be based on imaging studies and/or radioimmunoassays. Due to its location in the sella turcica, expansion of the tumor mass can impinge on the optic chiasm or involve the temporal lobe, third ventricle and posterior fossa A frequently associated physical finding is bitemporal hemianopsia which may progress to further visual loss.
Has_NICHD_Parent: NCIT C3262
Concept_In_Subset: NCIT C126659
Concept_In_Subset: NCIT C61410
Concept_In_Subset: NCIT C77526
Concept_In_Subset: NCIT C88025
Concept_In_Subset: NCIT C90259
code: C3329
Semantic_Type: Neoplastic Process
Preferred_Name: Pituitary Gland Adenoma
UMLS_CUI: C0032000
Contributing_Source: CDISC
Contributing_Source: NICHD
ALT_DEFINITION: A benign neoplasm of the anterior lobe of the pituitary gland.
ALT_DEFINITION: A non-metastasizing tumor that arises from the adenohypophysial cells of the anterior lobe of the pituitary gland.
ICD-O-3_Code: 8272/0
Neoplastic_Status: Benign
Legacy_Concept_Name: Pituitary_Gland_Adenoma
NICHD_Hierarchy_Term: Pituitary Gland Adenoma
has exact synonym: ADENOMA, ANTERIOR LOBE PITUITARY GLAND, BENIGN
has exact synonym: Adenoma of Pituitary
has exact synonym: Adenoma of Pituitary Gland
has exact synonym: Adenoma of the Pituitary
has exact synonym: Adenoma of the Pituitary Gland
has exact synonym: Pituitary Adenoma
has exact synonym: Pituitary Gland Adenoma
in subset: oncotree slim

Axiom
annotated source: Pituitary Gland Adenoma
annotated property: definition
annotated target: A non-metastasizing tumor that arises from the adenohypophysial cells of the anterior lobe of the pituitary gland. The tumor can be hormonally functioning or not. The diagnosis can be based on imaging studies and/or radioimmunoassays. Due to its location in the sella turcica, expansion of the tumor mass can impinge on the optic chiasm or involve the temporal lobe, third ventricle and posterior fossa A frequently associated physical finding is bitemporal hemianopsia which may progress to further visual loss.
def-source: NCI

Axiom
annotated source: Pituitary Gland Adenoma
annotated property: ALT_DEFINITION
annotated target: A benign neoplasm of the anterior lobe of the pituitary gland.
def-source: CDISC

Axiom
annotated source: Pituitary Gland Adenoma
annotated property: ALT_DEFINITION
annotated target: A non-metastasizing tumor that arises from the adenohypophysial cells of the anterior lobe of the pituitary gland.
def-source: NICHD

Axiom
annotated source: Pituitary Gland Adenoma
annotated property: has exact synonym
annotated target: ADENOMA, ANTERIOR LOBE PITUITARY GLAND, BENIGN
term-group: PT
term-source: CDISC

Axiom
annotated source: Pituitary Gland Adenoma
annotated property: has exact synonym
annotated target: Adenoma of Pituitary
term-group: SY
term-source: CDISC

Axiom
annotated source: Pituitary Gland Adenoma
annotated property: has exact synonym
annotated target: Adenoma of Pituitary
term-group: SY
term-source: NCI

Axiom
annotated source: Pituitary Gland Adenoma
annotated property: has exact synonym
annotated target: Adenoma of Pituitary Gland
term-group: SY
term-source: CDISC

Axiom
annotated source: Pituitary Gland Adenoma
annotated property: has exact synonym
annotated target: Adenoma of Pituitary Gland
term-group: SY
term-source: NCI

Axiom
annotated source: Pituitary Gland Adenoma
annotated property: has exact synonym
annotated target: Adenoma of the Pituitary
term-group: SY
term-source: CDISC

Axiom
annotated source: Pituitary Gland Adenoma
annotated property: has exact synonym
annotated target: Adenoma of the Pituitary
term-group: SY
term-source: NCI

Axiom
annotated source: Pituitary Gland Adenoma
annotated property: has exact synonym
annotated target: Adenoma of the Pituitary Gland
term-group: SY
term-source: CDISC

Axiom
annotated source: Pituitary Gland Adenoma
annotated property: has exact synonym
annotated target: Adenoma of the Pituitary Gland
term-group: SY
term-source: NCI

Axiom
annotated source: Pituitary Gland Adenoma
annotated property: has exact synonym
annotated target: Pituitary Adenoma
term-group: SY
term-source: CDISC

Axiom
annotated source: Pituitary Gland Adenoma
annotated property: has exact synonym
annotated target: Pituitary Adenoma
term-group: SY
term-source: NCI

Axiom
annotated source: Pituitary Gland Adenoma
annotated property: has exact synonym
annotated target: Pituitary Gland Adenoma
term-group: PT
term-source: NCI

Axiom
annotated source: Pituitary Gland Adenoma
annotated property: has exact synonym
annotated target: Pituitary Gland Adenoma
term-group: PT
term-source: NICHD

Polycythemia Vera
type: Class
subclass of: Myeloproliferative Neoplasm
definition: A chronic myeloproliferative neoplasm characterized by an increased red blood cell production. The bone marrow is hypercellular due to a panmyelotic proliferation typically characterized by pleomorphic megakaryocytes. The major symptoms are related to hypertension, splenomegaly or to episodes of thrombosis and/or hemorrhage.
Has_NICHD_Parent: NCIT C9305
Concept_In_Subset: NCIT C102905
Concept_In_Subset: NCIT C103126
Concept_In_Subset: NCIT C116977
Concept_In_Subset: NCIT C126659
Concept_In_Subset: NCIT C90259
Concept_In_Subset: NCIT C99147
code: C3336
Semantic_Type: Neoplastic Process
Display_Name: Polycythemia Vera
Preferred_Name: Polycythemia Vera
UMLS_CUI: C0032463
Contributing_Source: CTEP
Contributing_Source: CTRP
Contributing_Source: NICHD
ALT_DEFINITION: A disease in which there are too many red blood cells in the bone marrow and blood, causing the blood to thicken. The number of white blood cells and platelets may also increase. The extra blood cells may collect in the spleen and cause it to become enlarged. They may also cause bleeding problems and make clots form in blood vessels.
ICD-O-3_Code: 9950/3
Neoplastic_Status: Malignant
Legacy_Concept_Name: Polycythemia_Vera
NICHD_Hierarchy_Term: Polycythemia Vera
has exact synonym: Polycythemia Rubra Vera
has exact synonym: Polycythemia Vera
has exact synonym: Polycythemia vera
has exact synonym: polycythemia vera
in subset: oncotree slim

Axiom
annotated source: Polycythemia Vera
annotated property: definition
annotated target: A chronic myeloproliferative neoplasm characterized by an increased red blood cell production. The bone marrow is hypercellular due to a panmyelotic proliferation typically characterized by pleomorphic megakaryocytes. The major symptoms are related to hypertension, splenomegaly or to episodes of thrombosis and/or hemorrhage.
def-source: NCI

Axiom
annotated source: Polycythemia Vera
annotated property: ALT_DEFINITION
annotated target: A disease in which there are too many red blood cells in the bone marrow and blood, causing the blood to thicken. The number of white blood cells and platelets may also increase. The extra blood cells may collect in the spleen and cause it to become enlarged. They may also cause bleeding problems and make clots form in blood vessels.
def-source: NCI-GLOSS

Axiom
annotated source: Polycythemia Vera
annotated property: has exact synonym
annotated target: Polycythemia Rubra Vera
term-group: SY
term-source: NCI

Axiom
annotated source: Polycythemia Vera
annotated property: has exact synonym
annotated target: Polycythemia Vera
term-group: PT
term-source: NCI

Axiom
annotated source: Polycythemia Vera
annotated property: has exact synonym
annotated target: Polycythemia Vera
term-group: PT
term-source: NICHD

Axiom
annotated source: Polycythemia Vera
annotated property: has exact synonym
annotated target: Polycythemia Vera
term-group: SY
term-source: NCI
source-code: TCGA
subsource-name: caDSR

Axiom
annotated source: Polycythemia Vera
annotated property: has exact synonym
annotated target: Polycythemia vera
term-group: PT
term-source: CTEP
source-code: 10036061
subsource-name: SDC

Axiom
annotated source: Polycythemia Vera
annotated property: has exact synonym
annotated target: polycythemia vera
term-group: PT
term-source: NCI-GLOSS
source-code: CDR0000426418

Rhabdomyosarcoma
type: Class
definition: A rare aggressive malignant mesenchymal neoplasm arising from skeletal muscle. It usually occurs in children and young adults. Only a small percentage of tumors arise in the skeletal muscle of the extremities. The majority arise in other anatomical sites.
Has_NICHD_Parent: NCIT C9306
Concept_In_Subset: NCIT C102905
Concept_In_Subset: NCIT C103118
Concept_In_Subset: NCIT C118464
Concept_In_Subset: NCIT C126659
Concept_In_Subset: NCIT C61410
Concept_In_Subset: NCIT C77526
Concept_In_Subset: NCIT C88025
Concept_In_Subset: NCIT C90259
Concept_In_Subset: NCIT C99147
code: C3359
Semantic_Type: Neoplastic Process
Display_Name: Rhabdomyosarcoma
Preferred_Name: Rhabdomyosarcoma
UMLS_CUI: C0035412
Contributing_Source: CDISC
Contributing_Source: CTEP
Contributing_Source: MedDRA
Contributing_Source: NICHD
ALT_DEFINITION: A malignant mesenchymal neoplasm arising from skeletal muscle.
ALT_DEFINITION: A malignant neoplasm arising from skeletal myocytes.
ALT_DEFINITION: Cancer that forms in the soft tissues in a type of muscle called striated muscle. Rhabdomyosarcoma can occur anywhere in the body.
ICD-O-3_Code: 8900/3
Neoplastic_Status: Malignant
Legacy_Concept_Name: Rhabdomyosarcoma
NICHD_Hierarchy_Term: Rhabdomyosarcoma
has exact synonym: RHABDOMYOSARCOMA, MALIGNANT
has exact synonym: Rhabdomyosarcoma
has exact synonym: Rhabdomyosarcoma, NOS
has exact synonym: rhabdomyosarcoma
in subset: oncotree slim

Axiom
annotated source: Rhabdomyosarcoma
annotated property: definition
annotated target: A rare aggressive malignant mesenchymal neoplasm arising from skeletal muscle. It usually occurs in children and young adults. Only a small percentage of tumors arise in the skeletal muscle of the extremities. The majority arise in other anatomical sites.
def-source: NCI

Axiom
annotated source: Rhabdomyosarcoma
annotated property: ALT_DEFINITION
annotated target: A malignant mesenchymal neoplasm arising from skeletal muscle.
def-source: CDISC

Axiom
annotated source: Rhabdomyosarcoma
annotated property: ALT_DEFINITION
annotated target: A malignant neoplasm arising from skeletal myocytes.
def-source: NICHD

Axiom
annotated source: Rhabdomyosarcoma
annotated property: ALT_DEFINITION
annotated target: Cancer that forms in the soft tissues in a type of muscle called striated muscle. Rhabdomyosarcoma can occur anywhere in the body.
def-source: NCI-GLOSS

Axiom
annotated source: Rhabdomyosarcoma
annotated property: has exact synonym
annotated target: RHABDOMYOSARCOMA, MALIGNANT
term-group: PT
term-source: CDISC

Axiom
annotated source: Rhabdomyosarcoma
annotated property: has exact synonym
annotated target: Rhabdomyosarcoma
term-group: PT
term-source: NCI

Axiom
annotated source: Rhabdomyosarcoma
annotated property: has exact synonym
annotated target: Rhabdomyosarcoma
term-group: PT
term-source: NICHD

Axiom
annotated source: Rhabdomyosarcoma
annotated property: has exact synonym
annotated target: Rhabdomyosarcoma, NOS
term-group: PT
term-source: CTEP
source-code: 10039024
subsource-name: SDC

Axiom
annotated source: Rhabdomyosarcoma
annotated property: has exact synonym
annotated target: rhabdomyosarcoma
term-group: PT
term-source: NCI-GLOSS
source-code: CDR0000045872

Sezary Syndrome
type: Class
definition: A generalized peripheral (mature) T-cell neoplasm characterized by the presence of erythroderma, lymphadenopathy, and neoplastic, cerebriform T-lymphocytes in the blood. Sezary syndrome is an aggressive disease. (WHO, 2001)
Concept_In_Subset: NCIT C102905
Concept_In_Subset: NCIT C103133
Concept_In_Subset: NCIT C116977
Concept_In_Subset: NCIT C126659
code: C3366
Semantic_Type: Neoplastic Process
Display_Name: Sezary Syndrome
Preferred_Name: Sezary Syndrome
UMLS_CUI: C0036920
Contributing_Source: CTEP
Contributing_Source: CTRP
ALT_DEFINITION: A form of cutaneous T-cell lymphoma, a cancerous disease that affects the skin.
ICD-O-3_Code: 9701/3
Neoplastic_Status: Malignant
Legacy_Concept_Name: Sezary_Syndrome
has exact synonym: CTCL / Sezary syndrome
has exact synonym: Cutaneous T-cell lymphoma/Sezary syndrome
has exact synonym: Sezary Syndrome
has exact synonym: Sezary syndrome
has exact synonym: Sezary's Disease
has exact synonym: Sézary Syndrome
in subset: oncotree slim

Axiom
annotated source: Sezary Syndrome
annotated property: definition
annotated target: A generalized peripheral (mature) T-cell neoplasm characterized by the presence of erythroderma, lymphadenopathy, and neoplastic, cerebriform T-lymphocytes in the blood. Sezary syndrome is an aggressive disease. (WHO, 2001)
def-source: NCI

Axiom
annotated source: Sezary Syndrome
annotated property: ALT_DEFINITION
annotated target: A form of cutaneous T-cell lymphoma, a cancerous disease that affects the skin.
def-source: NCI-GLOSS

Axiom
annotated source: Sezary Syndrome
annotated property: has exact synonym
annotated target: CTCL / Sezary syndrome
term-group: SY
term-source: CTEP
source-code: 10011677
subsource-name: SDC

Axiom
annotated source: Sezary Syndrome
annotated property: has exact synonym
annotated target: Cutaneous T-cell lymphoma/Sezary syndrome
term-group: PT
term-source: CTEP
source-code: 10011677
subsource-name: SDC

Axiom
annotated source: Sezary Syndrome
annotated property: has exact synonym
annotated target: Sezary Syndrome
term-group: DN
term-source: CTRP

Axiom
annotated source: Sezary Syndrome
annotated property: has exact synonym
annotated target: Sezary Syndrome
term-group: PT
term-source: NCI

Axiom
annotated source: Sezary Syndrome
annotated property: has exact synonym
annotated target: Sezary Syndrome
term-group: SY
term-source: NCI
source-code: TCGA
subsource-name: caDSR

Axiom
annotated source: Sezary Syndrome
annotated property: has exact synonym
annotated target: Sezary syndrome
term-group: PT
term-source: NCI-GLOSS
source-code: CDR0000045878

Axiom
annotated source: Sezary Syndrome
annotated property: has exact synonym
annotated target: Sezary's Disease
term-group: SY
term-source: NCI

Axiom
annotated source: Sezary Syndrome
annotated property: has exact synonym
annotated target: Sézary Syndrome
term-group: SY
term-source: NCI

Synovial Sarcoma
type: Class
definition: A malignant neoplasm characterized by the chromosomal translocation t(X;18)(p11;q11). It can occur at any age, but mainly affects young adults, more commonly males. Although any site can be affected, the vast majority of the cases arise in the deep soft tissues of extremities, especially around the knee. Microscopically, synovial sarcoma is classified as monophasic (with a spindle or epithelial cell component) or biphasic (with both spindle and epithelial cell components). Synovial sarcomas can recur or metastasize to the lungs, bones, and lymph nodes.
Concept_In_Subset: NCIT C102905
Concept_In_Subset: NCIT C103117
Concept_In_Subset: NCIT C61410
Concept_In_Subset: NCIT C77526
Concept_In_Subset: NCIT C88025
code: C3400
Semantic_Type: Neoplastic Process
Preferred_Name: Synovial Sarcoma
UMLS_CUI: C0039101
Contributing_Source: CDISC
Contributing_Source: CTEP
ALT_DEFINITION: A malignant neoplasm that usually arises in the synovial membranes of the joints and the synovial cells of the tendons and bursae.
ALT_DEFINITION: A malignant tumor that develops in the synovial membrane of the joints.
ICD-O-3_Code: 9040/3
Neoplastic_Status: Malignant
Legacy_Concept_Name: Synovial_Sarcoma
has exact synonym: SARCOMA, SYNOVIAL, MALIGNANT
has exact synonym: SS
has exact synonym: Synovial Sarcoma
has exact synonym: Synovial Sarcoma, NOS
has exact synonym: Synovial Sarcoma, Not Otherwise Specified
has exact synonym: Synovial sarcoma
has exact synonym: synovial sarcoma
in subset: oncotree slim

Axiom
annotated source: Synovial Sarcoma
annotated property: definition
annotated target: A malignant neoplasm characterized by the chromosomal translocation t(X;18)(p11;q11). It can occur at any age, but mainly affects young adults, more commonly males. Although any site can be affected, the vast majority of the cases arise in the deep soft tissues of extremities, especially around the knee. Microscopically, synovial sarcoma is classified as monophasic (with a spindle or epithelial cell component) or biphasic (with both spindle and epithelial cell components). Synovial sarcomas can recur or metastasize to the lungs, bones, and lymph nodes.
def-source: NCI

Axiom
annotated source: Synovial Sarcoma
annotated property: ALT_DEFINITION
annotated target: A malignant neoplasm that usually arises in the synovial membranes of the joints and the synovial cells of the tendons and bursae.
def-source: CDISC

Axiom
annotated source: Synovial Sarcoma
annotated property: ALT_DEFINITION
annotated target: A malignant tumor that develops in the synovial membrane of the joints.
def-source: NCI-GLOSS

Axiom
annotated source: Synovial Sarcoma
annotated property: has exact synonym
annotated target: SARCOMA, SYNOVIAL, MALIGNANT
term-group: PT
term-source: CDISC

Axiom
annotated source: Synovial Sarcoma
annotated property: has exact synonym
annotated target: SS
term-group: AB
term-source: NCI

Axiom
annotated source: Synovial Sarcoma
annotated property: has exact synonym
annotated target: SS
term-group: SY
term-source: CDISC

Axiom
annotated source: Synovial Sarcoma
annotated property: has exact synonym
annotated target: Synovial Sarcoma
term-group: PT
term-source: NCI

Axiom
annotated source: Synovial Sarcoma
annotated property: has exact synonym
annotated target: Synovial Sarcoma, NOS
term-group: SY
term-source: NCI

Axiom
annotated source: Synovial Sarcoma
annotated property: has exact synonym
annotated target: Synovial Sarcoma, Not Otherwise Specified
term-group: SY
term-source: NCI

Axiom
annotated source: Synovial Sarcoma
annotated property: has exact synonym
annotated target: Synovial sarcoma
term-group: PT
term-source: CTEP
source-code: 10042866
subsource-name: SDC

Axiom
annotated source: Synovial Sarcoma
annotated property: has exact synonym
annotated target: synovial sarcoma
term-group: PT
term-source: NCI-GLOSS
source-code: CDR0000044626

Essential Thrombocythemia
type: Class
subclass of: Myeloproliferative Neoplasm
definition: A chronic myeloproliferative neoplasm that involves primarily the megakaryocytic lineage. It is characterized by sustained thrombocytosis in the blood, increased numbers of large, mature megakaryocytes in the bone marrow, and episodes of thrombosis and/or hemorrhage. (WHO, 2008)
Has_NICHD_Parent: NCIT C35530
Concept_In_Subset: NCIT C102905
Concept_In_Subset: NCIT C103126
Concept_In_Subset: NCIT C116977
Concept_In_Subset: NCIT C126659
Concept_In_Subset: NCIT C132009
Concept_In_Subset: NCIT C90259
code: C3407
Semantic_Type: Neoplastic Process
Display_Name: Essential Thrombocythemia
Preferred_Name: Essential Thrombocythemia
UMLS_CUI: C0040028
Contributing_Source: CTEP
Contributing_Source: CTRP
Contributing_Source: NICHD
ALT_DEFINITION: A chronic condition that involves primarily the megakaryocytic lineage. It is characterized by sustained thrombocytosis in the blood, increased numbers of large, mature megakaryocytes in the bone marrow, and elevated risk for thrombosis and/or hemorrhage.
ALT_DEFINITION: An increased number of thrombocytes (platelets) in the blood, without a known cause.
ICD-O-3_Code: 9962/3
Neoplastic_Status: Malignant
Legacy_Concept_Name: Essential_Thrombocythemia
NICHD_Hierarchy_Term: Essential Thrombocythemia
has exact synonym: ET
has exact synonym: Essential Thrombocytemia
has exact synonym: Essential Thrombocythemia
has exact synonym: Essential Thrombocytosis
has exact synonym: Essential thrombocythemia
has exact synonym: Idiopathic Thrombocythemia
has exact synonym: Primary Thrombocythemia
has exact synonym: Primary Thrombocytosis
has exact synonym: essential thrombocythemia
has exact synonym: essential thrombocytosis
in subset: oncotree slim

Axiom
annotated source: Essential Thrombocythemia
annotated property: definition
annotated target: A chronic myeloproliferative neoplasm that involves primarily the megakaryocytic lineage. It is characterized by sustained thrombocytosis in the blood, increased numbers of large, mature megakaryocytes in the bone marrow, and episodes of thrombosis and/or hemorrhage. (WHO, 2008)
def-source: NCI

Axiom
annotated source: Essential Thrombocythemia
annotated property: ALT_DEFINITION
annotated target: A chronic condition that involves primarily the megakaryocytic lineage. It is characterized by sustained thrombocytosis in the blood, increased numbers of large, mature megakaryocytes in the bone marrow, and elevated risk for thrombosis and/or hemorrhage.
def-source: NICHD

Axiom
annotated source: Essential Thrombocythemia
annotated property: ALT_DEFINITION
annotated target: An increased number of thrombocytes (platelets) in the blood, without a known cause.
def-source: NCI-GLOSS

Axiom
annotated source: Essential Thrombocythemia
annotated property: has exact synonym
annotated target: ET
term-group: SY
term-source: NICHD

Axiom
annotated source: Essential Thrombocythemia
annotated property: has exact synonym
annotated target: Essential Thrombocytemia
term-group: SY
term-source: NCI

Axiom
annotated source: Essential Thrombocythemia
annotated property: has exact synonym
annotated target: Essential Thrombocythemia
term-group: PT
term-source: NCI

Axiom
annotated source: Essential Thrombocythemia
annotated property: has exact synonym
annotated target: Essential Thrombocythemia
term-group: PT
term-source: NICHD

Axiom
annotated source: Essential Thrombocythemia
annotated property: has exact synonym
annotated target: Essential Thrombocythemia
term-group: SY
term-source: NCI
source-code: TCGA
subsource-name: caDSR

Axiom
annotated source: Essential Thrombocythemia
annotated property: has exact synonym
annotated target: Essential Thrombocytosis
term-group: SY
term-source: NCI

Axiom
annotated source: Essential Thrombocythemia
annotated property: has exact synonym
annotated target: Essential Thrombocytosis
term-group: SY
term-source: NICHD

Axiom
annotated source: Essential Thrombocythemia
annotated property: has exact synonym
annotated target: Essential thrombocythemia
term-group: PT
term-source: CTEP
source-code: 10015493
subsource-name: SDC

Axiom
annotated source: Essential Thrombocythemia
annotated property: has exact synonym
annotated target: Idiopathic Thrombocythemia
term-group: SY
term-source: NCI

Axiom
annotated source: Essential Thrombocythemia
annotated property: has exact synonym
annotated target: Primary Thrombocythemia
term-group: SY
term-source: NCI

Axiom
annotated source: Essential Thrombocythemia
annotated property: has exact synonym
annotated target: Primary Thrombocytosis
term-group: SY
term-source: NCI

Axiom
annotated source: Essential Thrombocythemia
annotated property: has exact synonym
annotated target: essential thrombocythemia
term-group: PT
term-source: NCI-GLOSS
source-code: CDR0000256562

Axiom
annotated source: Essential Thrombocythemia
annotated property: has exact synonym
annotated target: essential thrombocytosis
term-group: PT
term-source: NCI-GLOSS
source-code: CDR0000256561

Thymoma
type: Class
subclass of: Thymus Epithelial Neoplasm
definition: A neoplasm arising from the epithelial cells of the thymus. Although thymomas are usually encapsulated tumors, they may invade the capsule and infiltrate the surrounding tissues or even metastasize to distant anatomic sites. The following morphologic subtypes are currently recognized: type A, type B, type AB, metaplastic, micronodular, microscopic, and sclerosing thymoma. Thymomas type B are further subdivided into types B1, B2, and B3. Thymoma type B3 usually has the most aggressive clinical course.
Concept_In_Subset: NCIT C102905
Concept_In_Subset: NCIT C103088
Concept_In_Subset: NCIT C126659
code: C3411
Semantic_Type: Neoplastic Process
Preferred_Name: Thymoma
UMLS_CUI: C0040100
Contributing_Source: CTEP
ALT_DEFINITION: A tumor of the thymus, an organ that is part of the lymphatic system and is located in the chest, behind the breastbone.
ICD-O-3_Code: 8580/1
Neoplastic_Status: Undetermined
Legacy_Concept_Name: Thymoma
has exact synonym: Thymoma
has exact synonym: thymoma
in subset: oncotree slim

Axiom
annotated source: Thymoma
annotated property: definition
annotated target: A neoplasm arising from the epithelial cells of the thymus. Although thymomas are usually encapsulated tumors, they may invade the capsule and infiltrate the surrounding tissues or even metastasize to distant anatomic sites. The following morphologic subtypes are currently recognized: type A, type B, type AB, metaplastic, micronodular, microscopic, and sclerosing thymoma. Thymomas type B are further subdivided into types B1, B2, and B3. Thymoma type B3 usually has the most aggressive clinical course.
def-source: NCI

Axiom
annotated source: Thymoma
annotated property: ALT_DEFINITION
annotated target: A tumor of the thymus, an organ that is part of the lymphatic system and is located in the chest, behind the breastbone.
def-source: NCI-GLOSS

Axiom
annotated source: Thymoma
annotated property: has exact synonym
annotated target: Thymoma
term-group: DN
term-source: CTRP

Axiom
annotated source: Thymoma
annotated property: has exact synonym
annotated target: Thymoma
term-group: PT
term-source: CTEP
source-code: 10043673
subsource-name: SDC

Axiom
annotated source: Thymoma
annotated property: has exact synonym
annotated target: Thymoma
term-group: PT
term-source: CTRP

Axiom
annotated source: Thymoma
annotated property: has exact synonym
annotated target: Thymoma
term-group: PT
term-source: NCI

Axiom
annotated source: Thymoma
annotated property: has exact synonym
annotated target: thymoma
term-group: PT
term-source: NCI-GLOSS
source-code: CDR0000046002

Uterine Corpus Leiomyoma
type: Class
subclass of: Uterine Corpus Smooth Muscle Neoplasm
definition: A benign smooth muscle neoplasm arising from the body of the uterus. It is characterized by the presence of spindle cells with cigar-shaped nuclei, interlacing fascicles, and a whorled pattern.
Concept_In_Subset: NCIT C116977
Concept_In_Subset: NCIT C126659
code: C3434
Semantic_Type: Neoplastic Process
Display_Name: Uterine Corpus Leiomyoma
Preferred_Name: Uterine Corpus Leiomyoma
UMLS_CUI: C0042133
Contributing_Source: CTRP
Neoplastic_Status: Benign
Legacy_Concept_Name: Uterine_Corpus_Leiomyoma
has exact synonym: Body of Uterus Fibroid
has exact synonym: Body of Uterus Leiomyoma
has exact synonym: Corpus Uteri Fibroid
has exact synonym: Corpus Uteri Leiomyoma
has exact synonym: Fibroid of Body of Uterus
has exact synonym: Fibroid of Corpus Uteri
has exact synonym: Fibroid of Uterine Body
has exact synonym: Fibroid of Uterine Corpus
has exact synonym: Fibroid of the Body of Uterus
has exact synonym: Fibroid of the Corpus Uteri
has exact synonym: Fibroid of the Uterine Body
has exact synonym: Fibroid of the Uterine Corpus
has exact synonym: Leiomyoma of Body of Uterus
has exact synonym: Leiomyoma of Corpus Uteri
has exact synonym: Leiomyoma of Uterine Body
has exact synonym: Leiomyoma of Uterine Corpus
has exact synonym: Leiomyoma of the Body of Uterus
has exact synonym: Leiomyoma of the Corpus Uteri
has exact synonym: Leiomyoma of the Uterine Body
has exact synonym: Leiomyoma of the Uterine Corpus
has exact synonym: Uterine Body Fibroid
has exact synonym: Uterine Body Leiomyoma
has exact synonym: Uterine Corpus Fibroid
has exact synonym: Uterine Corpus Leiomyoma
has exact synonym: Uterine Corpus Leiomyomata
has exact synonym: Uterine Fibroid
in subset: oncotree slim

Axiom
annotated source: Uterine Corpus Leiomyoma
annotated property: definition
annotated target: A benign smooth muscle neoplasm arising from the body of the uterus. It is characterized by the presence of spindle cells with cigar-shaped nuclei, interlacing fascicles, and a whorled pattern.
def-source: NCI

Axiom
annotated source: Uterine Corpus Leiomyoma
annotated property: has exact synonym
annotated target: Body of Uterus Fibroid
term-group: SY
term-source: NCI

Axiom
annotated source: Uterine Corpus Leiomyoma
annotated property: has exact synonym
annotated target: Body of Uterus Leiomyoma
term-group: SY
term-source: NCI

Axiom
annotated source: Uterine Corpus Leiomyoma
annotated property: has exact synonym
annotated target: Corpus Uteri Fibroid
term-group: SY
term-source: NCI

Axiom
annotated source: Uterine Corpus Leiomyoma
annotated property: has exact synonym
annotated target: Corpus Uteri Leiomyoma
term-group: SY
term-source: NCI

Axiom
annotated source: Uterine Corpus Leiomyoma
annotated property: has exact synonym
annotated target: Fibroid of Body of Uterus
term-group: SY
term-source: NCI

Axiom
annotated source: Uterine Corpus Leiomyoma
annotated property: has exact synonym
annotated target: Fibroid of Corpus Uteri
term-group: SY
term-source: NCI

Axiom
annotated source: Uterine Corpus Leiomyoma
annotated property: has exact synonym
annotated target: Fibroid of Uterine Body
term-group: SY
term-source: NCI

Axiom
annotated source: Uterine Corpus Leiomyoma
annotated property: has exact synonym
annotated target: Fibroid of Uterine Corpus
term-group: SY
term-source: NCI

Axiom
annotated source: Uterine Corpus Leiomyoma
annotated property: has exact synonym
annotated target: Fibroid of the Body of Uterus
term-group: SY
term-source: NCI

Axiom
annotated source: Uterine Corpus Leiomyoma
annotated property: has exact synonym
annotated target: Fibroid of the Corpus Uteri
term-group: SY
term-source: NCI

Axiom
annotated source: Uterine Corpus Leiomyoma
annotated property: has exact synonym
annotated target: Fibroid of the Uterine Body
term-group: SY
term-source: NCI

Axiom
annotated source: Uterine Corpus Leiomyoma
annotated property: has exact synonym
annotated target: Fibroid of the Uterine Corpus
term-group: SY
term-source: NCI

Axiom
annotated source: Uterine Corpus Leiomyoma
annotated property: has exact synonym
annotated target: Leiomyoma of Body of Uterus
term-group: SY
term-source: NCI

Axiom
annotated source: Uterine Corpus Leiomyoma
annotated property: has exact synonym
annotated target: Leiomyoma of Corpus Uteri
term-group: SY
term-source: NCI

Axiom
annotated source: Uterine Corpus Leiomyoma
annotated property: has exact synonym
annotated target: Leiomyoma of Uterine Body
term-group: SY
term-source: NCI

Axiom
annotated source: Uterine Corpus Leiomyoma
annotated property: has exact synonym
annotated target: Leiomyoma of Uterine Corpus
term-group: SY
term-source: NCI

Axiom
annotated source: Uterine Corpus Leiomyoma
annotated property: has exact synonym
annotated target: Leiomyoma of the Body of Uterus
term-group: SY
term-source: NCI

Axiom
annotated source: Uterine Corpus Leiomyoma
annotated property: has exact synonym
annotated target: Leiomyoma of the Corpus Uteri
term-group: SY
term-source: NCI

Axiom
annotated source: Uterine Corpus Leiomyoma
annotated property: has exact synonym
annotated target: Leiomyoma of the Uterine Body
term-group: SY
term-source: NCI

Axiom
annotated source: Uterine Corpus Leiomyoma
annotated property: has exact synonym
annotated target: Leiomyoma of the Uterine Corpus
term-group: SY
term-source: NCI

Axiom
annotated source: Uterine Corpus Leiomyoma
annotated property: has exact synonym
annotated target: Uterine Body Fibroid
term-group: SY
term-source: NCI

Axiom
annotated source: Uterine Corpus Leiomyoma
annotated property: has exact synonym
annotated target: Uterine Body Leiomyoma
term-group: SY
term-source: NCI

Axiom
annotated source: Uterine Corpus Leiomyoma
annotated property: has exact synonym
annotated target: Uterine Corpus Fibroid
term-group: SY
term-source: NCI

Axiom
annotated source: Uterine Corpus Leiomyoma
annotated property: has exact synonym
annotated target: Uterine Corpus Leiomyoma
term-group: PT
term-source: NCI

Axiom
annotated source: Uterine Corpus Leiomyoma
annotated property: has exact synonym
annotated target: Uterine Corpus Leiomyomata
term-group: SY
term-source: NCI

Axiom
annotated source: Uterine Corpus Leiomyoma
annotated property: has exact synonym
annotated target: Uterine Fibroid
term-group: SY
term-source: NCI

Head and Neck Squamous Cell Carcinoma
type: Class
subclass of: Head and Neck Carcinoma
definition: A squamous cell carcinoma that arises from any of the following anatomic sites: lip and oral cavity, nasal cavity, paranasal sinuses, pharynx, larynx, and salivary glands.
Concept_In_Subset: NCIT C102905
Concept_In_Subset: NCIT C103075
Concept_In_Subset: NCIT C126659
code: C34447
Semantic_Type: Neoplastic Process
Preferred_Name: Head and Neck Squamous Cell Carcinoma
UMLS_CUI: C1168401
Contributing_Source: CTEP
ALT_DEFINITION: Cancer of the head and neck that begins in squamous cells (thin, flat cells that form the surface of the skin, eyes, various internal organs, and the lining of hollow organs and ducts of some glands). Squamous cell carcinoma of the head and neck includes cancers of the nasal cavity, sinuses, lips, mouth, salivary glands, throat, and larynx (voice box). Most head and neck cancers are squamous cell carcinomas.
Neoplastic_Status: Malignant
Legacy_Concept_Name: Head_and_Neck_Squamous_Cell_Carcinoma
has exact synonym: Head and Neck Squamous Cell Carcinoma
has exact synonym: Head and neck squamous cell carcinoma, NOS
has exact synonym: SCCHN
has exact synonym: Squamous Cell Carcinoma of Head and Neck
has exact synonym: Squamous Cell Carcinoma of the Head and Neck
has exact synonym: squamous cell carcinoma of the head and neck
in subset: oncotree slim

Axiom
annotated source: Head and Neck Squamous Cell Carcinoma
annotated property: definition
annotated target: A squamous cell carcinoma that arises from any of the following anatomic sites: lip and oral cavity, nasal cavity, paranasal sinuses, pharynx, larynx, and salivary glands.
def-source: NCI

Axiom
annotated source: Head and Neck Squamous Cell Carcinoma
annotated property: ALT_DEFINITION
annotated target: Cancer of the head and neck that begins in squamous cells (thin, flat cells that form the surface of the skin, eyes, various internal organs, and the lining of hollow organs and ducts of some glands). Squamous cell carcinoma of the head and neck includes cancers of the nasal cavity, sinuses, lips, mouth, salivary glands, throat, and larynx (voice box). Most head and neck cancers are squamous cell carcinomas.
def-source: NCI-GLOSS

Axiom
annotated source: Head and Neck Squamous Cell Carcinoma
annotated property: has exact synonym
annotated target: Head and Neck Squamous Cell Carcinoma
term-group: PT
term-source: NCI

Axiom
annotated source: Head and Neck Squamous Cell Carcinoma
annotated property: has exact synonym
annotated target: Head and Neck Squamous Cell Carcinoma
term-group: SY
term-source: NCI
source-code: TCGA
subsource-name: caDSR

Axiom
annotated source: Head and Neck Squamous Cell Carcinoma
annotated property: has exact synonym
annotated target: Head and neck squamous cell carcinoma, NOS
term-group: PT
term-source: CTEP
source-code: 10060121
subsource-name: SDC

Axiom
annotated source: Head and Neck Squamous Cell Carcinoma
annotated property: has exact synonym
annotated target: SCCHN
term-group: AB
term-source: NCI

Axiom
annotated source: Head and Neck Squamous Cell Carcinoma
annotated property: has exact synonym
annotated target: Squamous Cell Carcinoma of Head and Neck
term-group: SY
term-source: NCI

Axiom
annotated source: Head and Neck Squamous Cell Carcinoma
annotated property: has exact synonym
annotated target: Squamous Cell Carcinoma of the Head and Neck
term-group: SY
term-source: NCI

Axiom
annotated source: Head and Neck Squamous Cell Carcinoma
annotated property: has exact synonym
annotated target: squamous cell carcinoma of the head and neck
term-group: PT
term-source: NCI-GLOSS
source-code: CDR0000597171

B-Cell Non-Hodgkin Lymphoma
type: Class
subclass of: Non-Hodgkin Lymphoma
definition: The most common type of non-Hodgkin lymphoma. It includes the most frequently seen morphologic variants which are: diffuse large B-cell lymphoma, follicular lymphoma, small lymphocytic lymphoma and marginal zone B-cell lymphoma. -- 2003
Concept_In_Subset: NCIT C126659
code: C3457
Semantic_Type: Neoplastic Process
Preferred_Name: B-Cell Non-Hodgkin Lymphoma
NCI_META_CUI: CL448793
ALT_DEFINITION: A type of cancer that forms in B cells (a type of immune system cell). B-cell lymphomas usually occur in adults and may be either indolent (slow-growing) or aggressive (fast-growing). There are many different types of B-cell lymphomas, and prognosis and treatment depend on the type and stage of cancer.
Neoplastic_Status: Malignant
Legacy_Concept_Name: B-Cell_Non-Hodgkin_s_Lymphoma
has exact synonym: B-Cell Non Hodgkin's Lymphoma
has exact synonym: B-Cell Non-Hodgkin Lymphoma
has exact synonym: B-Cell Non-Hodgkin's Lymphoma
has exact synonym: B-cell lymphoma
has exact synonym: Lymphomas Non-Hodgkin's B-Cell
has exact synonym: Non-Hodgkin's B-Cell Lymphoma
has exact synonym: Non-Hodgkin's Lymphoma B-Cell
in subset: oncotree slim

Axiom
annotated source: B-Cell Non-Hodgkin Lymphoma
annotated property: definition
annotated target: The most common type of non-Hodgkin lymphoma. It includes the most frequently seen morphologic variants which are: diffuse large B-cell lymphoma, follicular lymphoma, small lymphocytic lymphoma and marginal zone B-cell lymphoma. -- 2003
def-source: NCI

Axiom
annotated source: B-Cell Non-Hodgkin Lymphoma
annotated property: ALT_DEFINITION
annotated target: A type of cancer that forms in B cells (a type of immune system cell). B-cell lymphomas usually occur in adults and may be either indolent (slow-growing) or aggressive (fast-growing). There are many different types of B-cell lymphomas, and prognosis and treatment depend on the type and stage of cancer.
def-source: NCI-GLOSS

Axiom
annotated source: B-Cell Non-Hodgkin Lymphoma
annotated property: has exact synonym
annotated target: B-Cell Non Hodgkin's Lymphoma
term-group: SY
term-source: NCI

Axiom
annotated source: B-Cell Non-Hodgkin Lymphoma
annotated property: has exact synonym
annotated target: B-Cell Non-Hodgkin Lymphoma
term-group: DN
term-source: CTRP

Axiom
annotated source: B-Cell Non-Hodgkin Lymphoma
annotated property: has exact synonym
annotated target: B-Cell Non-Hodgkin Lymphoma
term-group: PT
term-source: NCI

Axiom
annotated source: B-Cell Non-Hodgkin Lymphoma
annotated property: has exact synonym
annotated target: B-Cell Non-Hodgkin's Lymphoma
term-group: SY
term-source: NCI

Axiom
annotated source: B-Cell Non-Hodgkin Lymphoma
annotated property: has exact synonym
annotated target: B-cell lymphoma
term-group: PT
term-source: NCI-GLOSS
source-code: CDR0000444967

Axiom
annotated source: B-Cell Non-Hodgkin Lymphoma
annotated property: has exact synonym
annotated target: Lymphomas Non-Hodgkin's B-Cell
term-group: SY
term-source: NCI

Axiom
annotated source: B-Cell Non-Hodgkin Lymphoma
annotated property: has exact synonym
annotated target: Non-Hodgkin's B-Cell Lymphoma
term-group: SY
term-source: NCI

Axiom
annotated source: B-Cell Non-Hodgkin Lymphoma
annotated property: has exact synonym
annotated target: Non-Hodgkin's Lymphoma B-Cell
term-group: SY
term-source: NCI

T-Cell Non-Hodgkin Lymphoma
type: Class
subclass of: Non-Hodgkin Lymphoma
definition: A non-Hodgkin lymphoma of T-cell lineage. It includes the T lymphoblastic lymphoma and the mature T- and NK-cell lymphomas. -- 2003
Concept_In_Subset: NCIT C126659
code: C3466
Semantic_Type: Neoplastic Process
Preferred_Name: T-Cell Non-Hodgkin Lymphoma
UMLS_CUI: C0079772
ALT_DEFINITION: A disease in which certain cells of the lymph system (called T lymphocytes) become cancer.
Neoplastic_Status: Malignant
Legacy_Concept_Name: T-Cell_Non-Hodgkin_s_Lymphoma
has exact synonym: Non-Hodgkin's T-Cell Lymphoma
has exact synonym: T Cell Lymphoma
has exact synonym: T-Cell Lymphoma
has exact synonym: T-Cell Non-Hodgkin Lymphoma
has exact synonym: T-Cell Non-Hodgkin's Lymphoma
has exact synonym: T-Cell and NK-Cell Non-Hodgkin Lymphoma
has exact synonym: T-Cell and NK-Cell Non-Hodgkin's Lymphoma
has exact synonym: T-cell lymphoma
in subset: oncotree slim

Axiom
annotated source: T-Cell Non-Hodgkin Lymphoma
annotated property: definition
annotated target: A non-Hodgkin lymphoma of T-cell lineage. It includes the T lymphoblastic lymphoma and the mature T- and NK-cell lymphomas. -- 2003
def-source: NCI

Axiom
annotated source: T-Cell Non-Hodgkin Lymphoma
annotated property: ALT_DEFINITION
annotated target: A disease in which certain cells of the lymph system (called T lymphocytes) become cancer.
def-source: NCI-GLOSS

Axiom
annotated source: T-Cell Non-Hodgkin Lymphoma
annotated property: has exact synonym
annotated target: Non-Hodgkin's T-Cell Lymphoma
term-group: SY
term-source: NCI

Axiom
annotated source: T-Cell Non-Hodgkin Lymphoma
annotated property: has exact synonym
annotated target: T Cell Lymphoma
term-group: SY
term-source: NCI

Axiom
annotated source: T-Cell Non-Hodgkin Lymphoma
annotated property: has exact synonym
annotated target: T-Cell Lymphoma
term-group: SY
term-source: NCI

Axiom
annotated source: T-Cell Non-Hodgkin Lymphoma
annotated property: has exact synonym
annotated target: T-Cell Non-Hodgkin Lymphoma
term-group: DN
term-source: CTRP

Axiom
annotated source: T-Cell Non-Hodgkin Lymphoma
annotated property: has exact synonym
annotated target: T-Cell Non-Hodgkin Lymphoma
term-group: PT
term-source: NCI

Axiom
annotated source: T-Cell Non-Hodgkin Lymphoma
annotated property: has exact synonym
annotated target: T-Cell Non-Hodgkin's Lymphoma
term-group: SY
term-source: NCI

Axiom
annotated source: T-Cell Non-Hodgkin Lymphoma
annotated property: has exact synonym
annotated target: T-Cell and NK-Cell Non-Hodgkin Lymphoma
term-group: SY
term-source: NCI

Axiom
annotated source: T-Cell Non-Hodgkin Lymphoma
annotated property: has exact synonym
annotated target: T-Cell and NK-Cell Non-Hodgkin's Lymphoma
term-group: SY
term-source: NCI

Axiom
annotated source: T-Cell Non-Hodgkin Lymphoma
annotated property: has exact synonym
annotated target: T-cell lymphoma
term-group: PT
term-source: NCI-GLOSS
source-code: CDR0000045924

Primary Cutaneous T-Cell Non-Hodgkin Lymphoma
type: Class
definition: A T-cell non-Hodgkin lymphoma arising from the skin. Representative examples include mycosis fungoides and primary cutaneous anaplastic large cell lymphoma.
Concept_In_Subset: NCIT C116977
Concept_In_Subset: NCIT C126659
code: C3467
Semantic_Type: Neoplastic Process
Display_Name: Cutaneous T-Cell Non-Hodgkin Lymphoma
Preferred_Name: Primary Cutaneous T-Cell Non-Hodgkin Lymphoma
UMLS_CUI: C0079773
Contributing_Source: CTRP
ALT_DEFINITION: Any of a group of T-cell non-Hodgkin lymphomas that begins in the skin as an itchy, red rash that can thicken or form a tumor. The most common types are mycosis fungoides and Sezary syndrome.
ICD-O-3_Code: 9709/3
Neoplastic_Status: Malignant
Legacy_Concept_Name: Cutaneous_T-Cell_Lymphoma
has exact synonym: CTCL
has exact synonym: Cutaneous T Cell Lymphoma
has exact synonym: Cutaneous T-Cell Non-Hodgkin Lymphoma
has exact synonym: Cutaneous T-Cell Non-Hodgkin's Lymphoma
has exact synonym: PCTCL
has exact synonym: Primary Cutaneous T-Cell Non-Hodgkin Lymphoma
has exact synonym: Primary Cutaneous T-Cell Non-Hodgkin's Lymphoma
has exact synonym: Skin T-Cell Non-Hodgkin's Lymphoma
has exact synonym: T-Cell Non-Hodgkin's Lymphoma of Skin
has exact synonym: T-Cell Non-Hodgkin's Lymphoma of the Skin
has exact synonym: cutaneous T-cell lymphoma
in subset: oncotree slim

Axiom
annotated source: Primary Cutaneous T-Cell Non-Hodgkin Lymphoma
annotated property: definition
annotated target: A T-cell non-Hodgkin lymphoma arising from the skin. Representative examples include mycosis fungoides and primary cutaneous anaplastic large cell lymphoma.
def-source: NCI

Axiom
annotated source: Primary Cutaneous T-Cell Non-Hodgkin Lymphoma
annotated property: ALT_DEFINITION
annotated target: Any of a group of T-cell non-Hodgkin lymphomas that begins in the skin as an itchy, red rash that can thicken or form a tumor. The most common types are mycosis fungoides and Sezary syndrome.
def-source: NCI-GLOSS

Axiom
annotated source: Primary Cutaneous T-Cell Non-Hodgkin Lymphoma
annotated property: has exact synonym
annotated target: CTCL
term-group: AB
term-source: NCI

Axiom
annotated source: Primary Cutaneous T-Cell Non-Hodgkin Lymphoma
annotated property: has exact synonym
annotated target: Cutaneous T Cell Lymphoma
term-group: SY
term-source: NCI

Axiom
annotated source: Primary Cutaneous T-Cell Non-Hodgkin Lymphoma
annotated property: has exact synonym
annotated target: Cutaneous T-Cell Non-Hodgkin Lymphoma
term-group: DN
term-source: CTRP

Axiom
annotated source: Primary Cutaneous T-Cell Non-Hodgkin Lymphoma
annotated property: has exact synonym
annotated target: Cutaneous T-Cell Non-Hodgkin Lymphoma
term-group: SY
term-source: NCI

Axiom
annotated source: Primary Cutaneous T-Cell Non-Hodgkin Lymphoma
annotated property: has exact synonym
annotated target: Cutaneous T-Cell Non-Hodgkin's Lymphoma
term-group: SY
term-source: NCI

Axiom
annotated source: Primary Cutaneous T-Cell Non-Hodgkin Lymphoma
annotated property: has exact synonym
annotated target: PCTCL
term-group: AB
term-source: NCI

Axiom
annotated source: Primary Cutaneous T-Cell Non-Hodgkin Lymphoma
annotated property: has exact synonym
annotated target: Primary Cutaneous T-Cell Non-Hodgkin Lymphoma
term-group: PT
term-source: NCI

Axiom
annotated source: Primary Cutaneous T-Cell Non-Hodgkin Lymphoma
annotated property: has exact synonym
annotated target: Primary Cutaneous T-Cell Non-Hodgkin's Lymphoma
term-group: SY
term-source: NCI

Axiom
annotated source: Primary Cutaneous T-Cell Non-Hodgkin Lymphoma
annotated property: has exact synonym
annotated target: Skin T-Cell Non-Hodgkin's Lymphoma
term-group: SY
term-source: NCI

Axiom
annotated source: Primary Cutaneous T-Cell Non-Hodgkin Lymphoma
annotated property: has exact synonym
annotated target: T-Cell Non-Hodgkin's Lymphoma of Skin
term-group: SY
term-source: NCI

Axiom
annotated source: Primary Cutaneous T-Cell Non-Hodgkin Lymphoma
annotated property: has exact synonym
annotated target: T-Cell Non-Hodgkin's Lymphoma of the Skin
term-group: SY
term-source: NCI

Axiom
annotated source: Primary Cutaneous T-Cell Non-Hodgkin Lymphoma
annotated property: has exact synonym
annotated target: cutaneous T-cell lymphoma
term-group: PT
term-source: NCI-GLOSS
source-code: CDR0000046771

Choroid Plexus Neoplasm
type: Class
definition: An intraventricular papillary neoplasm that originates from the choroid plexus epithelium. It includes the choroid plexus papilloma, atypical choroid plexus papilloma, and choroid plexus carcinoma.
code: C3473
Semantic_Type: Neoplastic Process
Preferred_Name: Choroid Plexus Neoplasm
UMLS_CUI: C0085138
ALT_DEFINITION: A rare type of cancer that occurs in the ventricles of the brain. It usually occurs in children younger than 2 years.
Neoplastic_Status: Undetermined
Legacy_Concept_Name: Choroid_Plexus_Neoplasm
has exact synonym: Choroid Plexus Neoplasm
has exact synonym: Choroid Plexus Tumor
has exact synonym: Neoplasm of Choroid Plexus
has exact synonym: Neoplasm of the Choroid Plexus
has exact synonym: Tumor of Choroid Plexus
has exact synonym: Tumor of the Choroid Plexus
has exact synonym: choroid plexus tumor
in subset: oncotree slim

Axiom
annotated source: Choroid Plexus Neoplasm
annotated property: definition
annotated target: An intraventricular papillary neoplasm that originates from the choroid plexus epithelium. It includes the choroid plexus papilloma, atypical choroid plexus papilloma, and choroid plexus carcinoma.
def-source: NCI

Axiom
annotated source: Choroid Plexus Neoplasm
annotated property: ALT_DEFINITION
annotated target: A rare type of cancer that occurs in the ventricles of the brain. It usually occurs in children younger than 2 years.
def-source: NCI-GLOSS

Axiom
annotated source: Choroid Plexus Neoplasm
annotated property: has exact synonym
annotated target: Choroid Plexus Neoplasm
term-group: PT
term-source: NCI

Axiom
annotated source: Choroid Plexus Neoplasm
annotated property: has exact synonym
annotated target: Choroid Plexus Tumor
term-group: SY
term-source: NCI

Axiom
annotated source: Choroid Plexus Neoplasm
annotated property: has exact synonym
annotated target: Neoplasm of Choroid Plexus
term-group: SY
term-source: NCI

Axiom
annotated source: Choroid Plexus Neoplasm
annotated property: has exact synonym
annotated target: Neoplasm of the Choroid Plexus
term-group: SY
term-source: NCI

Axiom
annotated source: Choroid Plexus Neoplasm
annotated property: has exact synonym
annotated target: Tumor of Choroid Plexus
term-group: SY
term-source: NCI

Axiom
annotated source: Choroid Plexus Neoplasm
annotated property: has exact synonym
annotated target: Tumor of the Choroid Plexus
term-group: SY
term-source: NCI

Axiom
annotated source: Choroid Plexus Neoplasm
annotated property: has exact synonym
annotated target: choroid plexus tumor
term-group: PT
term-source: NCI-GLOSS
source-code: CDR0000046185

Granular Cell Tumor
type: Class
subclass of: Nerve Sheath Neoplasm
definition: An unusual benign or malignant neoplasm characterized by the presence of neoplastic large polygonal cells with granular, eosinophilic cytoplasm which contains abundant lysosomes. It was originally thought to be a tumor originating from muscle cells and was named granular cell myoblastoma. Subsequent studies have suggested a derivation from Schwann cells. It affects females more often than males and it usually presents as a solitary mass. A minority of patients have multiple tumors. It can arise from many anatomic sites including the posterior pituitary gland, skin, oral cavity, esophagus, stomach, heart, mediastinum, and breast.
Concept_In_Subset: NCIT C126659
code: C3474
Semantic_Type: Neoplastic Process
Preferred_Name: Granular Cell Tumor
UMLS_CUI: C0085167
ICD-O-3_Code: 9580/0
Neoplastic_Status: Undetermined
Legacy_Concept_Name: Granular_Cell_Tumor
has exact synonym: Abrikossoff Tumor
has exact synonym: Abrikossoff's Tumor
has exact synonym: Granular Cell Myoblastoma
has exact synonym: Granular Cell Neoplasm
has exact synonym: Granular Cell Nerve Sheath Tumor
has exact synonym: Granular Cell Schwannoma
has exact synonym: Granular Cell Tumor
in subset: oncotree slim

Axiom
annotated source: Granular Cell Tumor
annotated property: definition
annotated target: An unusual benign or malignant neoplasm characterized by the presence of neoplastic large polygonal cells with granular, eosinophilic cytoplasm which contains abundant lysosomes. It was originally thought to be a tumor originating from muscle cells and was named granular cell myoblastoma. Subsequent studies have suggested a derivation from Schwann cells. It affects females more often than males and it usually presents as a solitary mass. A minority of patients have multiple tumors. It can arise from many anatomic sites including the posterior pituitary gland, skin, oral cavity, esophagus, stomach, heart, mediastinum, and breast.
def-source: NCI

Axiom
annotated source: Granular Cell Tumor
annotated property: has exact synonym
annotated target: Abrikossoff Tumor
term-group: SY
term-source: NCI

Axiom
annotated source: Granular Cell Tumor
annotated property: has exact synonym
annotated target: Abrikossoff's Tumor
term-group: SY
term-source: NCI

Axiom
annotated source: Granular Cell Tumor
annotated property: has exact synonym
annotated target: Granular Cell Myoblastoma
term-group: SY
term-source: NCI

Axiom
annotated source: Granular Cell Tumor
annotated property: has exact synonym
annotated target: Granular Cell Neoplasm
term-group: SY
term-source: NCI

Axiom
annotated source: Granular Cell Tumor
annotated property: has exact synonym
annotated target: Granular Cell Nerve Sheath Tumor
term-group: SY
term-source: NCI

Axiom
annotated source: Granular Cell Tumor
annotated property: has exact synonym
annotated target: Granular Cell Schwannoma
term-group: SY
term-source: NCI

Axiom
annotated source: Granular Cell Tumor
annotated property: has exact synonym
annotated target: Granular Cell Tumor
term-group: PT
term-source: NCI

Squamous Cell Lung Carcinoma
type: Class
definition: A carcinoma arising from squamous bronchial epithelial cells. It may be keratinizing or non-keratinizing. Keratinizing squamous cell carcinoma is characterized by the presence of keratinization, pearl formation, and/or intercellular bridges. Non-keratinizing squamous cell carcinoma is characterized by the absence of keratinization, pearl formation, and intercellular bridges. Cigarette smoking and arsenic exposure are strongly associated with squamous cell lung carcinoma.
Concept_In_Subset: NCIT C102905
Concept_In_Subset: NCIT C103090
Concept_In_Subset: NCIT C116977
Concept_In_Subset: NCIT C126659
code: C3493
Semantic_Type: Neoplastic Process
Display_Name: Squamous Cell Lung Cancer
Preferred_Name: Squamous Cell Lung Carcinoma
UMLS_CUI: C0149782
Contributing_Source: CTEP
Contributing_Source: CTRP
Neoplastic_Status: Malignant
Legacy_Concept_Name: Squamous_Cell_Lung_Carcinoma
has exact synonym: Epidermoid Cell Carcinoma of Lung
has exact synonym: Epidermoid Cell Carcinoma of the Lung
has exact synonym: Epidermoid Cell Lung Carcinoma
has exact synonym: Squamous Cell Carcinoma of Lung
has exact synonym: Squamous Cell Carcinoma of the Lung
has exact synonym: Squamous Cell Lung Cancer
has exact synonym: Squamous Cell Lung Carcinoma
has exact synonym: Squamous cell lung carcinoma
in subset: oncotree slim

Axiom
annotated source: Squamous Cell Lung Carcinoma
annotated property: definition
annotated target: A carcinoma arising from squamous bronchial epithelial cells. It may be keratinizing or non-keratinizing. Keratinizing squamous cell carcinoma is characterized by the presence of keratinization, pearl formation, and/or intercellular bridges. Non-keratinizing squamous cell carcinoma is characterized by the absence of keratinization, pearl formation, and intercellular bridges. Cigarette smoking and arsenic exposure are strongly associated with squamous cell lung carcinoma.
def-source: NCI

Axiom
annotated source: Squamous Cell Lung Carcinoma
annotated property: has exact synonym
annotated target: Epidermoid Cell Carcinoma of Lung
term-group: SY
term-source: NCI

Axiom
annotated source: Squamous Cell Lung Carcinoma
annotated property: has exact synonym
annotated target: Epidermoid Cell Carcinoma of the Lung
term-group: SY
term-source: NCI

Axiom
annotated source: Squamous Cell Lung Carcinoma
annotated property: has exact synonym
annotated target: Epidermoid Cell Lung Carcinoma
term-group: SY
term-source: NCI

Axiom
annotated source: Squamous Cell Lung Carcinoma
annotated property: has exact synonym
annotated target: Squamous Cell Carcinoma of Lung
term-group: SY
term-source: NCI

Axiom
annotated source: Squamous Cell Lung Carcinoma
annotated property: has exact synonym
annotated target: Squamous Cell Carcinoma of the Lung
term-group: SY
term-source: NCI

Axiom
annotated source: Squamous Cell Lung Carcinoma
annotated property: has exact synonym
annotated target: Squamous Cell Lung Cancer
term-group: DN
term-source: CTRP

Axiom
annotated source: Squamous Cell Lung Carcinoma
annotated property: has exact synonym
annotated target: Squamous Cell Lung Carcinoma
term-group: PT
term-source: NCI

Axiom
annotated source: Squamous Cell Lung Carcinoma
annotated property: has exact synonym
annotated target: Squamous Cell Lung Carcinoma
term-group: SY
term-source: NCI
source-code: TCGA
subsource-name: caDSR

Axiom
annotated source: Squamous Cell Lung Carcinoma
annotated property: has exact synonym
annotated target: Squamous cell lung carcinoma
term-group: PT
term-source: CTEP
source-code: 10025126
subsource-name: SDC

Cutaneous Melanoma
type: Class
subclass of: Melanoma
definition: A primary melanoma arising from atypical melanocytes in the skin. Precursor lesions include acquired and congenital melanocytic nevi, and dysplastic nevi. Several histologic variants have been recognized, including superficial spreading melanoma, acral lentiginous melanoma, nodular melanoma, and lentigo maligna melanoma.
Concept_In_Subset: NCIT C116977
Concept_In_Subset: NCIT C126659
code: C3510
Semantic_Type: Neoplastic Process
Display_Name: Cutaneous Melanoma
Preferred_Name: Cutaneous Melanoma
UMLS_CUI: C0151779
Contributing_Source: CTRP
Neoplastic_Status: Malignant
Legacy_Concept_Name: Cutaneous_Melanoma
has exact synonym: Cutaneous (Skin) Melanoma
has exact synonym: Cutaneous Melanoma
has exact synonym: Malignant Cutaneous Melanoma
has exact synonym: Malignant Melanoma (of Skin), Stage Unspecified
has exact synonym: Malignant Melanoma of Skin
has exact synonym: Malignant Melanoma of Skin Stage Unspecified
has exact synonym: Melanoma of Skin
has exact synonym: Melanoma of the Skin
has exact synonym: Skin Melanoma
has exact synonym: Skin, Melanoma
in subset: oncotree slim

Axiom
annotated source: Cutaneous Melanoma
annotated property: definition
annotated target: A primary melanoma arising from atypical melanocytes in the skin. Precursor lesions include acquired and congenital melanocytic nevi, and dysplastic nevi. Several histologic variants have been recognized, including superficial spreading melanoma, acral lentiginous melanoma, nodular melanoma, and lentigo maligna melanoma.
def-source: NCI

Axiom
annotated source: Cutaneous Melanoma
annotated property: has exact synonym
annotated target: Cutaneous (Skin) Melanoma
term-group: DN
term-source: CTRP

Axiom
annotated source: Cutaneous Melanoma
annotated property: has exact synonym
annotated target: Cutaneous Melanoma
term-group: PT
term-source: CTRP

Axiom
annotated source: Cutaneous Melanoma
annotated property: has exact synonym
annotated target: Cutaneous Melanoma
term-group: PT
term-source: NCI

Axiom
annotated source: Cutaneous Melanoma
annotated property: has exact synonym
annotated target: Cutaneous Melanoma
term-group: SY
term-source: NCI
source-code: TCGA
subsource-name: caDSR

Axiom
annotated source: Cutaneous Melanoma
annotated property: has exact synonym
annotated target: Malignant Cutaneous Melanoma
term-group: SY
term-source: NCI

Axiom
annotated source: Cutaneous Melanoma
annotated property: has exact synonym
annotated target: Malignant Melanoma (of Skin), Stage Unspecified
term-group: SY
term-source: NCI

Axiom
annotated source: Cutaneous Melanoma
annotated property: has exact synonym
annotated target: Malignant Melanoma of Skin
term-group: SY
term-source: NCI

Axiom
annotated source: Cutaneous Melanoma
annotated property: has exact synonym
annotated target: Malignant Melanoma of Skin Stage Unspecified
term-group: SY
term-source: NCI

Axiom
annotated source: Cutaneous Melanoma
annotated property: has exact synonym
annotated target: Melanoma of Skin
term-group: SY
term-source: NCI

Axiom
annotated source: Cutaneous Melanoma
annotated property: has exact synonym
annotated target: Melanoma of the Skin
term-group: SY
term-source: NCI

Axiom
annotated source: Cutaneous Melanoma
annotated property: has exact synonym
annotated target: Skin Melanoma
term-group: SY
term-source: NCI

Axiom
annotated source: Cutaneous Melanoma
annotated property: has exact synonym
annotated target: Skin, Melanoma
term-group: SY
term-source: NCI

Lung Adenocarcinoma
type: Class
subclass of: Non-Small Cell Lung Carcinoma
definition: A carcinoma that arises from the lung and is characterized by the presence of malignant glandular epithelial cells. There is a male predilection with a male to female ratio of 2:1. Usually lung adenocarcinoma is asymptomatic and is identified through screening studies or as an incidental radiologic finding. If clinical symptoms are present they include shortness of breath, cough, hemoptysis, chest pain, and fever. Tobacco smoke is a known risk factor.
Concept_In_Subset: NCIT C102905
Concept_In_Subset: NCIT C103090
Concept_In_Subset: NCIT C116977
Concept_In_Subset: NCIT C126659
code: C3512
Semantic_Type: Neoplastic Process
Display_Name: Lung Adenocarcinoma
Preferred_Name: Lung Adenocarcinoma
UMLS_CUI: C0152013
Contributing_Source: CTEP
Contributing_Source: CTRP
Neoplastic_Status: Malignant
Legacy_Concept_Name: Lung_Adenocarcinoma
has exact synonym: Adenocarcinoma of Lung
has exact synonym: Adenocarcinoma of the Lung
has exact synonym: Lung Adenocarcinoma
has exact synonym: Lung adenocarcinoma
in subset: oncotree slim

Axiom
annotated source: Lung Adenocarcinoma
annotated property: definition
annotated target: A carcinoma that arises from the lung and is characterized by the presence of malignant glandular epithelial cells. There is a male predilection with a male to female ratio of 2:1. Usually lung adenocarcinoma is asymptomatic and is identified through screening studies or as an incidental radiologic finding. If clinical symptoms are present they include shortness of breath, cough, hemoptysis, chest pain, and fever. Tobacco smoke is a known risk factor.
def-source: NCI

Axiom
annotated source: Lung Adenocarcinoma
annotated property: has exact synonym
annotated target: Adenocarcinoma of Lung
term-group: SY
term-source: NCI

Axiom
annotated source: Lung Adenocarcinoma
annotated property: has exact synonym
annotated target: Adenocarcinoma of the Lung
term-group: SY
term-source: NCI

Axiom
annotated source: Lung Adenocarcinoma
annotated property: has exact synonym
annotated target: Lung Adenocarcinoma
term-group: DN
term-source: CTRP

Axiom
annotated source: Lung Adenocarcinoma
annotated property: has exact synonym
annotated target: Lung Adenocarcinoma
term-group: PT
term-source: NCI

Axiom
annotated source: Lung Adenocarcinoma
annotated property: has exact synonym
annotated target: Lung Adenocarcinoma
term-group: SY
term-source: NCI
source-code: TCGA
subsource-name: caDSR

Axiom
annotated source: Lung Adenocarcinoma
annotated property: has exact synonym
annotated target: Lung adenocarcinoma
term-group: PT
term-source: CTEP
source-code: 10025032
subsource-name: SDC

Intrahepatic Cholangiocarcinoma
type: Class
subclass of: Cholangiocarcinoma
definition: A carcinoma that arises from the intrahepatic bile duct epithelium in any site of the intrahepatic biliary tree. Grossly, the malignant lesions are solid, nodular, and grayish. Morphologically, the vast majority of cases are adenocarcinomas. Signs and symptoms include malaise, weight loss, right upper quadrant abdominal pain, and night sweats. Early detection is difficult and the prognosis is generally poor.
Concept_In_Subset: NCIT C126659
Concept_In_Subset: NCIT C61410
Concept_In_Subset: NCIT C77526
Concept_In_Subset: NCIT C88025
code: C35417
Semantic_Type: Neoplastic Process
Preferred_Name: Intrahepatic Cholangiocarcinoma
UMLS_CUI: C0345905
Contributing_Source: CDISC
ALT_DEFINITION: A malignant neoplasm of the liver arising from/comprising cells resembling those of bile ducts.
Neoplastic_Status: Malignant
Legacy_Concept_Name: Intrahepatic_Cholangiocarcinoma
has exact synonym: CHOLANGIOCARCINOMA, INTRAHEPATIC, MALIGNANT
has exact synonym: ICC
has exact synonym: Intrahepatic Bile Duct Carcinoma
has exact synonym: Intrahepatic Carcinoma of Bile Duct
has exact synonym: Intrahepatic Carcinoma of the Bile Duct
has exact synonym: Intrahepatic Cholangiocarcinoma
has exact synonym: Intrahepatic Cholangiocarcinoma (Bile Duct Cancer)
has exact synonym: Intrahepatic Cholangiocellular Carcinoma
in subset: oncotree slim

Axiom
annotated source: Intrahepatic Cholangiocarcinoma
annotated property: definition
annotated target: A carcinoma that arises from the intrahepatic bile duct epithelium in any site of the intrahepatic biliary tree. Grossly, the malignant lesions are solid, nodular, and grayish. Morphologically, the vast majority of cases are adenocarcinomas. Signs and symptoms include malaise, weight loss, right upper quadrant abdominal pain, and night sweats. Early detection is difficult and the prognosis is generally poor.
def-source: NCI

Axiom
annotated source: Intrahepatic Cholangiocarcinoma
annotated property: ALT_DEFINITION
annotated target: A malignant neoplasm of the liver arising from/comprising cells resembling those of bile ducts.
def-source: CDISC

Axiom
annotated source: Intrahepatic Cholangiocarcinoma
annotated property: has exact synonym
annotated target: CHOLANGIOCARCINOMA, INTRAHEPATIC, MALIGNANT
term-group: PT
term-source: CDISC

Axiom
annotated source: Intrahepatic Cholangiocarcinoma
annotated property: has exact synonym
annotated target: ICC
term-group: AB
term-source: NCI

Axiom
annotated source: Intrahepatic Cholangiocarcinoma
annotated property: has exact synonym
annotated target: Intrahepatic Bile Duct Carcinoma
term-group: SY
term-source: CDISC

Axiom
annotated source: Intrahepatic Cholangiocarcinoma
annotated property: has exact synonym
annotated target: Intrahepatic Bile Duct Carcinoma
term-group: SY
term-source: NCI

Axiom
annotated source: Intrahepatic Cholangiocarcinoma
annotated property: has exact synonym
annotated target: Intrahepatic Carcinoma of Bile Duct
term-group: SY
term-source: CDISC

Axiom
annotated source: Intrahepatic Cholangiocarcinoma
annotated property: has exact synonym
annotated target: Intrahepatic Carcinoma of Bile Duct
term-group: SY
term-source: NCI

Axiom
annotated source: Intrahepatic Cholangiocarcinoma
annotated property: has exact synonym
annotated target: Intrahepatic Carcinoma of the Bile Duct
term-group: SY
term-source: CDISC

Axiom
annotated source: Intrahepatic Cholangiocarcinoma
annotated property: has exact synonym
annotated target: Intrahepatic Carcinoma of the Bile Duct
term-group: SY
term-source: NCI

Axiom
annotated source: Intrahepatic Cholangiocarcinoma
annotated property: has exact synonym
annotated target: Intrahepatic Cholangiocarcinoma
term-group: PT
term-source: NCI

Axiom
annotated source: Intrahepatic Cholangiocarcinoma
annotated property: has exact synonym
annotated target: Intrahepatic Cholangiocarcinoma (Bile Duct Cancer)
term-group: DN
term-source: CTRP

Axiom
annotated source: Intrahepatic Cholangiocarcinoma
annotated property: has exact synonym
annotated target: Intrahepatic Cholangiocellular Carcinoma
term-group: AQS
term-source: NCI

Head and Neck Carcinoma
type: Class
definition: A carcinoma that arises from the head and neck region. Representative examples include oral cavity squamous cell carcinoma, laryngeal squamous cell carcinoma, and salivary gland carcinoma.
Concept_In_Subset: NCIT C126659
code: C35850
Semantic_Type: Neoplastic Process
Preferred_Name: Head and Neck Carcinoma
UMLS_CUI: C3887461
Neoplastic_Status: Malignant
Legacy_Concept_Name: Head_and_Neck_Carcinoma
has exact synonym: Carcinoma of Head and Neck
has exact synonym: Carcinoma of the Head and Neck
has exact synonym: Head and Neck Cancer
has exact synonym: Head and Neck Carcinoma
in subset: oncotree slim

Axiom
annotated source: Head and Neck Carcinoma
annotated property: definition
annotated target: A carcinoma that arises from the head and neck region. Representative examples include oral cavity squamous cell carcinoma, laryngeal squamous cell carcinoma, and salivary gland carcinoma.
def-source: NCI

Axiom
annotated source: Head and Neck Carcinoma
annotated property: has exact synonym
annotated target: Carcinoma of Head and Neck
term-group: SY
term-source: NCI

Axiom
annotated source: Head and Neck Carcinoma
annotated property: has exact synonym
annotated target: Carcinoma of the Head and Neck
term-group: SY
term-source: NCI

Axiom
annotated source: Head and Neck Carcinoma
annotated property: has exact synonym
annotated target: Head and Neck Cancer
term-group: DN
term-source: CTRP

Axiom
annotated source: Head and Neck Carcinoma
annotated property: has exact synonym
annotated target: Head and Neck Carcinoma
term-group: PT
term-source: CTRP

Axiom
annotated source: Head and Neck Carcinoma
annotated property: has exact synonym
annotated target: Head and Neck Carcinoma
term-group: PT
term-source: NCI

Axiom
annotated source: Head and Neck Carcinoma
annotated property: has exact synonym
annotated target: Head and Neck Carcinoma
term-group: SY
term-source: NCI
source-code: TCGA
subsource-name: caDSR

Appendix Goblet Cell Carcinoid
type: Class
definition: An invasive mixed adenoneuroendocrine carcinoma of the appendix characterized by a submucosal growth and the presence of neoplastic signet-ring cells resembling goblet cells of the intestine.
Concept_In_Subset: NCIT C126659
code: C3689
Semantic_Type: Neoplastic Process
Preferred_Name: Appendix Goblet Cell Carcinoid
NCI_META_CUI: CL512511
ICD-O-3_Code: 8243/3
Neoplastic_Status: Malignant
Legacy_Concept_Name: Goblet_Cell_Carcinoid_Tumor
has exact synonym: Appendix Adenocarcinoid Tumor
has exact synonym: Appendix Goblet Cell Carcinoid
has exact synonym: Appendix Goblet Cell Carcinoid Tumor
has exact synonym: Appendix Mixed Carcinoid-Adenocarcinoma
has exact synonym: Goblet Cell Carcinoid Tumor
has exact synonym: Mucinous Carcinoid Tumor
in subset: oncotree slim

Axiom
annotated source: Appendix Goblet Cell Carcinoid
annotated property: definition
annotated target: An invasive mixed adenoneuroendocrine carcinoma of the appendix characterized by a submucosal growth and the presence of neoplastic signet-ring cells resembling goblet cells of the intestine.
def-source: NCI

Axiom
annotated source: Appendix Goblet Cell Carcinoid
annotated property: has exact synonym
annotated target: Appendix Adenocarcinoid Tumor
term-group: SY
term-source: NCI

Axiom
annotated source: Appendix Goblet Cell Carcinoid
annotated property: has exact synonym
annotated target: Appendix Goblet Cell Carcinoid
term-group: PT
term-source: NCI

Axiom
annotated source: Appendix Goblet Cell Carcinoid
annotated property: has exact synonym
annotated target: Appendix Goblet Cell Carcinoid Tumor
term-group: SY
term-source: NCI

Axiom
annotated source: Appendix Goblet Cell Carcinoid
annotated property: has exact synonym
annotated target: Appendix Mixed Carcinoid-Adenocarcinoma
term-group: SY
term-source: NCI

Axiom
annotated source: Appendix Goblet Cell Carcinoid
annotated property: has exact synonym
annotated target: Goblet Cell Carcinoid Tumor
term-group: SY
term-source: NCI

Axiom
annotated source: Appendix Goblet Cell Carcinoid
annotated property: has exact synonym
annotated target: Mucinous Carcinoid Tumor
term-group: SY
term-source: NCI

Myxopapillary Ependymoma
type: Class
subclass of: Ependymal Tumor
definition: A slow growing, WHO grade I glioma which generally occurs in young adults. It arises almost exclusively in the conus medullaris, cauda equina, and filum terminale of the spinal cord. It generally has a favorable prognosis and is characterized histologically by tumor cells arranged in a papillary manner around vascularized mucoid stromal cores. (Adapted from WHO).
Concept_In_Subset: NCIT C126659
Concept_In_Subset: NCIT C61410
Concept_In_Subset: NCIT C77526
Concept_In_Subset: NCIT C88025
code: C3697
Semantic_Type: Neoplastic Process
Preferred_Name: Myxopapillary Ependymoma
UMLS_CUI: C0205769
Contributing_Source: CDISC
ALT_DEFINITION: A benign neoplasm of ependymal origin.
ICD-O-3_Code: 9394/1
Neoplastic_Status: Undetermined
Legacy_Concept_Name: Myxopapillary_Ependymoma
has exact synonym: EPENDYMOMA, BENIGN
has exact synonym: Myxopapillary Ependymoma
in subset: oncotree slim

Axiom
annotated source: Myxopapillary Ependymoma
annotated property: definition
annotated target: A slow growing, WHO grade I glioma which generally occurs in young adults. It arises almost exclusively in the conus medullaris, cauda equina, and filum terminale of the spinal cord. It generally has a favorable prognosis and is characterized histologically by tumor cells arranged in a papillary manner around vascularized mucoid stromal cores. (Adapted from WHO).
def-source: NCI

Axiom
annotated source: Myxopapillary Ependymoma
annotated property: ALT_DEFINITION
annotated target: A benign neoplasm of ependymal origin.
def-source: CDISC

Axiom
annotated source: Myxopapillary Ependymoma
annotated property: has exact synonym
annotated target: EPENDYMOMA, BENIGN
term-group: PT
term-source: CDISC

Axiom
annotated source: Myxopapillary Ependymoma
annotated property: has exact synonym
annotated target: Myxopapillary Ependymoma
term-group: PT
term-source: NCI

Axiom
annotated source: Myxopapillary Ependymoma
annotated property: has exact synonym
annotated target: Myxopapillary Ependymoma
term-group: SY
term-source: NCI
source-code: TCGA
subsource-name: caDSR

Choroid Plexus Papilloma
type: Class
definition: A benign, slow growing tumor which may cause symptoms by blocking cerebrospinal fluid pathways. It is characterized by the presence of delicate fibrovascular connective tissue fronds covered by a single layer of epithelial cells. Mitotic activity is extremely low. Surgical resection is usually curative. (Adapted from WHO)
Concept_In_Subset: NCIT C61410
Concept_In_Subset: NCIT C77526
Concept_In_Subset: NCIT C88025
code: C3698
Semantic_Type: Neoplastic Process
Preferred_Name: Choroid Plexus Papilloma
UMLS_CUI: C0205770
Contributing_Source: CDISC
ALT_DEFINITION: A benign neoplasm of the choroid plexus of the central nervous system.
ICD-O-3_Code: 9390/0
Neoplastic_Status: Benign
Legacy_Concept_Name: Choroid_Plexus_Papilloma
has exact synonym: Choroid Plexus Papilloma
has exact synonym: PAPILLOMA, CHOROID PLEXUS, BENIGN
has exact synonym: Papilloma of Choroid Plexus
has exact synonym: Papilloma of the Choroid Plexus
in subset: oncotree slim

Axiom
annotated source: Choroid Plexus Papilloma
annotated property: definition
annotated target: A benign, slow growing tumor which may cause symptoms by blocking cerebrospinal fluid pathways. It is characterized by the presence of delicate fibrovascular connective tissue fronds covered by a single layer of epithelial cells. Mitotic activity is extremely low. Surgical resection is usually curative. (Adapted from WHO)
def-source: NCI

Axiom
annotated source: Choroid Plexus Papilloma
annotated property: ALT_DEFINITION
annotated target: A benign neoplasm of the choroid plexus of the central nervous system.
def-source: CDISC

Axiom
annotated source: Choroid Plexus Papilloma
annotated property: has exact synonym
annotated target: Choroid Plexus Papilloma
term-group: PT
term-source: NCI

Axiom
annotated source: Choroid Plexus Papilloma
annotated property: has exact synonym
annotated target: Choroid Plexus Papilloma
term-group: SY
term-source: NCI
source-code: TCGA
subsource-name: caDSR

Axiom
annotated source: Choroid Plexus Papilloma
annotated property: has exact synonym
annotated target: PAPILLOMA, CHOROID PLEXUS, BENIGN
term-group: PT
term-source: CDISC

Axiom
annotated source: Choroid Plexus Papilloma
annotated property: has exact synonym
annotated target: Papilloma of Choroid Plexus
term-group: SY
term-source: CDISC

Axiom
annotated source: Choroid Plexus Papilloma
annotated property: has exact synonym
annotated target: Papilloma of Choroid Plexus
term-group: SY
term-source: NCI

Axiom
annotated source: Choroid Plexus Papilloma
annotated property: has exact synonym
annotated target: Papilloma of the Choroid Plexus
term-group: SY
term-source: CDISC

Axiom
annotated source: Choroid Plexus Papilloma
annotated property: has exact synonym
annotated target: Papilloma of the Choroid Plexus
term-group: SY
term-source: NCI

Dedifferentiated Liposarcoma
type: Class
subclass of: Liposarcoma
definition: An atypical lipomatous tumor/well differentiated liposarcoma that shows progression to a usually non-lipomatous, high grade sarcoma. The non-lipomatous sarcoma component may be present in the primary lesion or at the site of recurrence.
Concept_In_Subset: NCIT C126659
code: C3704
Semantic_Type: Neoplastic Process
Preferred_Name: Dedifferentiated Liposarcoma
UMLS_CUI: C0205824
ICD-O-3_Code: 8858/3
Neoplastic_Status: Malignant
Legacy_Concept_Name: Dedifferentiated_Liposarcoma
has exact synonym: Dedifferentiated Liposarcoma
in subset: oncotree slim

Axiom
annotated source: Dedifferentiated Liposarcoma
annotated property: definition
annotated target: An atypical lipomatous tumor/well differentiated liposarcoma that shows progression to a usually non-lipomatous, high grade sarcoma. The non-lipomatous sarcoma component may be present in the primary lesion or at the site of recurrence.
def-source: NCI

Axiom
annotated source: Dedifferentiated Liposarcoma
annotated property: has exact synonym
annotated target: Dedifferentiated Liposarcoma
term-group: PT
term-source: NCI

Axiom
annotated source: Dedifferentiated Liposarcoma
annotated property: has exact synonym
annotated target: Dedifferentiated Liposarcoma
term-group: SY
term-source: NCI
source-code: TCGA
subsource-name: caDSR

Pleomorphic Liposarcoma
type: Class
subclass of: Liposarcoma
definition: A liposarcoma characterized by the presence of varying proportions of pleomorphic lipoblasts in a background that resembles undifferentiated pleomorphic sarcoma. It is the rarest liposarcoma variant and usually has an aggressive clinical course.
Concept_In_Subset: NCIT C126659
code: C3705
Semantic_Type: Neoplastic Process
Preferred_Name: Pleomorphic Liposarcoma
UMLS_CUI: C0205825
ICD-O-3_Code: 8854/3
Neoplastic_Status: Malignant
Legacy_Concept_Name: Pleomorphic_Liposarcoma
has exact synonym: Pleomorphic Liposarcoma
in subset: oncotree slim

Axiom
annotated source: Pleomorphic Liposarcoma
annotated property: definition
annotated target: A liposarcoma characterized by the presence of varying proportions of pleomorphic lipoblasts in a background that resembles undifferentiated pleomorphic sarcoma. It is the rarest liposarcoma variant and usually has an aggressive clinical course.
def-source: NCI

Axiom
annotated source: Pleomorphic Liposarcoma
annotated property: has exact synonym
annotated target: Pleomorphic Liposarcoma
term-group: PT
term-source: NCI

Medullomyoblastoma with Myogenic Differentiation
type: Class
subclass of: Medulloblastoma
definition: A rare malignant embryonal neoplasm arising from the cerebellum. It is characterized by the morphologic features of a medulloblastoma and the presence of a striated muscle component. Its clinical behavior is similar to medulloblastoma.
code: C3706
Semantic_Type: Neoplastic Process
Preferred_Name: Medullomyoblastoma with Myogenic Differentiation
UMLS_CUI: C0205833
ICD-O-3_Code: 9472/3
Neoplastic_Status: Malignant
Legacy_Concept_Name: Medullomyoblastoma
has exact synonym: Medullomyoblastoma
has exact synonym: Medullomyoblastoma with Myogenic Differentiation
in subset: oncotree slim

Axiom
annotated source: Medullomyoblastoma with Myogenic Differentiation
annotated property: definition
annotated target: A rare malignant embryonal neoplasm arising from the cerebellum. It is characterized by the morphologic features of a medulloblastoma and the presence of a striated muscle component. Its clinical behavior is similar to medulloblastoma.
def-source: NCI

Axiom
annotated source: Medullomyoblastoma with Myogenic Differentiation
annotated property: has exact synonym
annotated target: Medullomyoblastoma
term-group: SY
term-source: NCI

Axiom
annotated source: Medullomyoblastoma with Myogenic Differentiation
annotated property: has exact synonym
annotated target: Medullomyoblastoma with Myogenic Differentiation
term-group: PT
term-source: NCI

Epithelioid Sarcoma
type: Class
definition: An aggressive malignant neoplasm of uncertain differentiation, characterized by the presence of epithelioid cells forming nodular patterns. The nodules often undergo central necrosis, resulting in a pseudogranulomatous growth pattern. It usually occurs in young adults. The most common sites of involvement are the extremities (distal-type epithelioid sarcoma), and less frequently the pelvis, perineum, and genital organs (proximal-type epithelioid sarcoma).
code: C3714
Semantic_Type: Neoplastic Process
Preferred_Name: Epithelioid Sarcoma
UMLS_CUI: C0205944
ICD-O-3_Code: 8804/3
Neoplastic_Status: Malignant
Legacy_Concept_Name: Epithelioid_Sarcoma
has exact synonym: ES
has exact synonym: Epithelioid Cell Sarcoma
has exact synonym: Epithelioid Sarcoma
in subset: oncotree slim

Axiom
annotated source: Epithelioid Sarcoma
annotated property: definition
annotated target: An aggressive malignant neoplasm of uncertain differentiation, characterized by the presence of epithelioid cells forming nodular patterns. The nodules often undergo central necrosis, resulting in a pseudogranulomatous growth pattern. It usually occurs in young adults. The most common sites of involvement are the extremities (distal-type epithelioid sarcoma), and less frequently the pelvis, perineum, and genital organs (proximal-type epithelioid sarcoma).
def-source: NCI

Axiom
annotated source: Epithelioid Sarcoma
annotated property: has exact synonym
annotated target: ES
term-group: AB
term-source: NCI

Axiom
annotated source: Epithelioid Sarcoma
annotated property: has exact synonym
annotated target: Epithelioid Cell Sarcoma
term-group: SY
term-source: NCI

Axiom
annotated source: Epithelioid Sarcoma
annotated property: has exact synonym
annotated target: Epithelioid Sarcoma
term-group: PT
term-source: NCI

Primitive Neuroectodermal Tumor
type: Class
subclass of: Embryonal Neoplasm
subclass of: Neuroepithelial Neoplasm
definition: A malignant neoplasm that originates in the neuroectoderm. The neuroectoderm constitutes the portion of the ectoderm of the early embryo that gives rise to the central and peripheral nervous systems and includes some glial cell precursors.
Concept_In_Subset: NCIT C116977
code: C3716
Semantic_Type: Neoplastic Process
Display_Name: Primitive Neuroectodermal Tumor
Preferred_Name: Primitive Neuroectodermal Tumor
UMLS_CUI: C0206663
Contributing_Source: CTRP
ALT_DEFINITION: One of a group of cancers that develop from the same type of early cells, and share certain biochemical and genetic features. Some PNETs develop in the brain and central nervous system (CNS-PNET), and others develop in sites outside of the brain such as the limbs, pelvis, and chest wall (peripheral PNET).
ICD-O-3_Code: 9473/3
ICD-O-3_Code: 9503/3
Neoplastic_Status: Malignant
Legacy_Concept_Name: Neuroectodermal_Tumor
has exact synonym: Neuroectodermal Neoplasm
has exact synonym: Neuroectodermal Tumor
has exact synonym: Neuroepithelioma
has exact synonym: PNET
has exact synonym: Primitive Neuroectodermal Neoplasm
has exact synonym: Primitive Neuroectodermal Tumor
has exact synonym: Primitive Neuroectodermal Tumor (PNET)
has exact synonym: neuroectodermal tumor
has exact synonym: primitive neuroectodermal tumor
in subset: oncotree slim

Axiom
annotated source: Primitive Neuroectodermal Tumor
annotated property: definition
annotated target: A malignant neoplasm that originates in the neuroectoderm. The neuroectoderm constitutes the portion of the ectoderm of the early embryo that gives rise to the central and peripheral nervous systems and includes some glial cell precursors.
def-source: NCI

Axiom
annotated source: Primitive Neuroectodermal Tumor
annotated property: ALT_DEFINITION
annotated target: One of a group of cancers that develop from the same type of early cells, and share certain biochemical and genetic features. Some PNETs develop in the brain and central nervous system (CNS-PNET), and others develop in sites outside of the brain such as the limbs, pelvis, and chest wall (peripheral PNET).
def-source: NCI-GLOSS

Axiom
annotated source: Primitive Neuroectodermal Tumor
annotated property: has exact synonym
annotated target: Neuroectodermal Neoplasm
term-group: SY
term-source: NCI

Axiom
annotated source: Primitive Neuroectodermal Tumor
annotated property: has exact synonym
annotated target: Neuroectodermal Tumor
term-group: SY
term-source: NCI

Axiom
annotated source: Primitive Neuroectodermal Tumor
annotated property: has exact synonym
annotated target: Neuroepithelioma
term-group: SY
term-source: NCI

Axiom
annotated source: Primitive Neuroectodermal Tumor
annotated property: has exact synonym
annotated target: PNET
term-group: AB
term-source: NCI

Axiom
annotated source: Primitive Neuroectodermal Tumor
annotated property: has exact synonym
annotated target: PNET
term-group: PT
term-source: NCI-GLOSS
source-code: CDR0000383924

Axiom
annotated source: Primitive Neuroectodermal Tumor
annotated property: has exact synonym
annotated target: Primitive Neuroectodermal Neoplasm
term-group: SY
term-source: NCI

Axiom
annotated source: Primitive Neuroectodermal Tumor
annotated property: has exact synonym
annotated target: Primitive Neuroectodermal Tumor
term-group: PT
term-source: CTRP

Axiom
annotated source: Primitive Neuroectodermal Tumor
annotated property: has exact synonym
annotated target: Primitive Neuroectodermal Tumor
term-group: PT
term-source: NCI

Axiom
annotated source: Primitive Neuroectodermal Tumor
annotated property: has exact synonym
annotated target: Primitive Neuroectodermal Tumor
term-group: SY
term-source: NCI
source-code: TCGA
subsource-name: caDSR

Axiom
annotated source: Primitive Neuroectodermal Tumor
annotated property: has exact synonym
annotated target: Primitive Neuroectodermal Tumor (PNET)
term-group: DN
term-source: CTRP

Axiom
annotated source: Primitive Neuroectodermal Tumor
annotated property: has exact synonym
annotated target: neuroectodermal tumor
term-group: PT
term-source: NCI-GLOSS
source-code: CDR0000045952

Axiom
annotated source: Primitive Neuroectodermal Tumor
annotated property: has exact synonym
annotated target: primitive neuroectodermal tumor
term-group: PT
term-source: NCI-GLOSS
source-code: CDR0000383920

Anaplastic Large Cell Lymphoma
type: Class
definition: A peripheral (mature) T-cell lymphoma, consisting of usually large anaplastic, CD30 positive cells. The majority of cases are positive for the anaplastic large cell lymphoma (ALK) protein. The most frequently seen genetic alteration is a t(2;5) translocation. Majority of patients present with advanced disease. The most important prognostic indicator is ALK positivity, which has been associated with a favorable prognosis. (WHO, 2001)
Has_CDRH_Parent: Lymphoma
Concept_In_Subset: NCIT C116977
Concept_In_Subset: NCIT C126659
Concept_In_Subset: NCIT C54450
Concept_In_Subset: NCIT C62596
code: C3720
Semantic_Type: Neoplastic Process
Display_Name: Anaplastic Large Cell Lymphoma
Preferred_Name: Anaplastic Large Cell Lymphoma
UMLS_CUI: C0206180
Contributing_Source: CTRP
Contributing_Source: FDA
ALT_DEFINITION: An aggressive (fast-growing) type of non-Hodgkin lymphoma that is usually of the T-cell type. The cancer cells express a marker called CD30 or Ki-1 on the surface, and may appear in the lymph nodes, skin, bones, soft tissues, lungs, or liver.
ICD-O-3_Code: 9714/3
Neoplastic_Status: Malignant
Legacy_Concept_Name: Anaplastic_Large_Cell_Lymphoma
has exact synonym: ALCL
has exact synonym: Anaplastic Large Cell Lymphoma
has exact synonym: CD30 Positive Anaplastic Large Cell Lymphoma
has exact synonym: Ki-1 Lymphoma
has exact synonym: Ki-1+ ALCL
has exact synonym: Ki-1+ Anaplastic Large Cell Lymphoma
has exact synonym: anaplastic large cell lymphoma
in subset: oncotree slim

Axiom
annotated source: Anaplastic Large Cell Lymphoma
annotated property: definition
annotated target: A peripheral (mature) T-cell lymphoma, consisting of usually large anaplastic, CD30 positive cells. The majority of cases are positive for the anaplastic large cell lymphoma (ALK) protein. The most frequently seen genetic alteration is a t(2;5) translocation. Majority of patients present with advanced disease. The most important prognostic indicator is ALK positivity, which has been associated with a favorable prognosis. (WHO, 2001)
def-source: NCI

Axiom
annotated source: Anaplastic Large Cell Lymphoma
annotated property: ALT_DEFINITION
annotated target: An aggressive (fast-growing) type of non-Hodgkin lymphoma that is usually of the T-cell type. The cancer cells express a marker called CD30 or Ki-1 on the surface, and may appear in the lymph nodes, skin, bones, soft tissues, lungs, or liver.
def-source: NCI-GLOSS

Axiom
annotated source: Anaplastic Large Cell Lymphoma
annotated property: has exact synonym
annotated target: ALCL
term-group: AB
term-source: NCI

Axiom
annotated source: Anaplastic Large Cell Lymphoma
annotated property: has exact synonym
annotated target: ALCL
term-group: PT
term-source: NCI-GLOSS
source-code: CDR0000575433

Axiom
annotated source: Anaplastic Large Cell Lymphoma
annotated property: has exact synonym
annotated target: ALCL
term-group: SY
term-source: FDA
source-code: 3264
subsource-name: CDRH

Axiom
annotated source: Anaplastic Large Cell Lymphoma
annotated property: has exact synonym
annotated target: Anaplastic Large Cell Lymphoma
term-group: DN
term-source: CTRP

Axiom
annotated source: Anaplastic Large Cell Lymphoma
annotated property: has exact synonym
annotated target: Anaplastic Large Cell Lymphoma
term-group: PT
term-source: FDA
source-code: 3264
subsource-name: CDRH

Axiom
annotated source: Anaplastic Large Cell Lymphoma
annotated property: has exact synonym
annotated target: Anaplastic Large Cell Lymphoma
term-group: PT
term-source: NCI

Axiom
annotated source: Anaplastic Large Cell Lymphoma
annotated property: has exact synonym
annotated target: Anaplastic Large Cell Lymphoma
term-group: SY
term-source: NCI
source-code: TCGA
subsource-name: caDSR

Axiom
annotated source: Anaplastic Large Cell Lymphoma
annotated property: has exact synonym
annotated target: CD30 Positive Anaplastic Large Cell Lymphoma
term-group: SY
term-source: NCI

Axiom
annotated source: Anaplastic Large Cell Lymphoma
annotated property: has exact synonym
annotated target: Ki-1 Lymphoma
term-group: AQS
term-source: NCI

Axiom
annotated source: Anaplastic Large Cell Lymphoma
annotated property: has exact synonym
annotated target: Ki-1+ ALCL
term-group: SY
term-source: NCI

Axiom
annotated source: Anaplastic Large Cell Lymphoma
annotated property: has exact synonym
annotated target: Ki-1+ Anaplastic Large Cell Lymphoma
term-group: SY
term-source: NCI

Axiom
annotated source: Anaplastic Large Cell Lymphoma
annotated property: has exact synonym
annotated target: anaplastic large cell lymphoma
term-group: PT
term-source: NCI-GLOSS
source-code: CDR0000045552

Solid Pseudopapillary Neoplasm of the Pancreas
type: Class
definition: A low-grade malignant neoplasm that arises from the exocrine pancreas. It is characterized by the presence of uniform cells that form solid and pseudopapillary patterns, cystic changes, and hemorrhage. Perineural invasion, vascular invasion, and invasion into surrounding tissues may be present. It usually presents as an encapsulated, solitary, and lobulated pancreatic mass. It is usually found incidentally during physical examination or it may present with abdominal discomfort and pain. It occurs predominantly in young women. Complete removal of the tumor is curative in the majority of cases.
code: C37212
Semantic_Type: Neoplastic Process
Preferred_Name: Solid Pseudopapillary Neoplasm of the Pancreas
UMLS_CUI: C1336030
ICD-O-3_Code: 8452/1
Neoplastic_Status: Undetermined
Legacy_Concept_Name: Solid_Pseudopapillary_Tumor_of_the_Pancreas
has exact synonym: Frantz Tumor
has exact synonym: Solid Pseudopapillary Neoplasm of the Pancreas
has exact synonym: Solid Pseudopapillary Tumor of the Pancreas
in subset: oncotree slim

Axiom
annotated source: Solid Pseudopapillary Neoplasm of the Pancreas
annotated property: definition
annotated target: A low-grade malignant neoplasm that arises from the exocrine pancreas. It is characterized by the presence of uniform cells that form solid and pseudopapillary patterns, cystic changes, and hemorrhage. Perineural invasion, vascular invasion, and invasion into surrounding tissues may be present. It usually presents as an encapsulated, solitary, and lobulated pancreatic mass. It is usually found incidentally during physical examination or it may present with abdominal discomfort and pain. It occurs predominantly in young women. Complete removal of the tumor is curative in the majority of cases.
def-source: NCI

Axiom
annotated source: Solid Pseudopapillary Neoplasm of the Pancreas
annotated property: has exact synonym
annotated target: Frantz Tumor
term-group: AQS
term-source: NCI

Axiom
annotated source: Solid Pseudopapillary Neoplasm of the Pancreas
annotated property: has exact synonym
annotated target: Solid Pseudopapillary Neoplasm of the Pancreas
term-group: PT
term-source: NCI

Axiom
annotated source: Solid Pseudopapillary Neoplasm of the Pancreas
annotated property: has exact synonym
annotated target: Solid Pseudopapillary Tumor of the Pancreas
term-group: AQS
term-source: NCI

Desmoplastic Melanoma
type: Class
subclass of: Cutaneous Melanoma
definition: A melanoma of the skin characterized by a proliferation of atypical spindled melanocytes in the dermis, in a background of abundant collagen. It usually presents as an amelanotic raised nodular lesion.
code: C37257
Semantic_Type: Neoplastic Process
Preferred_Name: Desmoplastic Melanoma
UMLS_CUI: C0334439
ALT_DEFINITION: A rare form of malignant melanoma marked by nonpigmented lesions on sun-exposed areas of the body, most commonly on the head and neck.
ICD-O-3_Code: 8745/3
Neoplastic_Status: Malignant
Legacy_Concept_Name: Desmoplastic_Melanoma
has exact synonym: Desmoplastic Cutaneous (Skin) Melanoma
has exact synonym: Desmoplastic Melanoma
has exact synonym: desmoplastic melanoma
in subset: oncotree slim

Axiom
annotated source: Desmoplastic Melanoma
annotated property: definition
annotated target: A melanoma of the skin characterized by a proliferation of atypical spindled melanocytes in the dermis, in a background of abundant collagen. It usually presents as an amelanotic raised nodular lesion.
def-source: NCI

Axiom
annotated source: Desmoplastic Melanoma
annotated property: ALT_DEFINITION
annotated target: A rare form of malignant melanoma marked by nonpigmented lesions on sun-exposed areas of the body, most commonly on the head and neck.
def-source: NCI-GLOSS

Axiom
annotated source: Desmoplastic Melanoma
annotated property: has exact synonym
annotated target: Desmoplastic Cutaneous (Skin) Melanoma
term-group: DN
term-source: CTRP

Axiom
annotated source: Desmoplastic Melanoma
annotated property: has exact synonym
annotated target: Desmoplastic Melanoma
term-group: PT
term-source: NCI

Axiom
annotated source: Desmoplastic Melanoma
annotated property: has exact synonym
annotated target: Desmoplastic Melanoma
term-group: SY
term-source: NCI
source-code: TCGA
subsource-name: caDSR

Axiom
annotated source: Desmoplastic Melanoma
annotated property: has exact synonym
annotated target: desmoplastic melanoma
term-group: PT
term-source: NCI-GLOSS
source-code: CDR0000321367

Hepatoblastoma
type: Class
subclass of: Embryonal Neoplasm
definition: A malignant liver neoplasm that occurs almost exclusively in infants, although isolated cases in older children and adults have been reported. Grossly, hepatoblastoma is solid, well circumscribed, and more often solitary than multiple. Microscopically, most of the tumors are composed exclusively of immature hepatocytic elements. About a fourth of hepatoblastomas contain a stromal component that may be undifferentiated or develop into bone or cartilage. The treatment of choice for hepatoblastoma is surgical excision with adjuvant therapy. Liver transplantation is being increasingly used as well.
Has_NICHD_Parent: NCIT C34803
Concept_In_Subset: NCIT C102905
Concept_In_Subset: NCIT C103066
Concept_In_Subset: NCIT C116977
Concept_In_Subset: NCIT C118464
Concept_In_Subset: NCIT C126659
Concept_In_Subset: NCIT C132009
Concept_In_Subset: NCIT C61410
Concept_In_Subset: NCIT C77526
Concept_In_Subset: NCIT C88025
Concept_In_Subset: NCIT C90259
Concept_In_Subset: NCIT C99147
code: C3728
Semantic_Type: Neoplastic Process
Display_Name: Hepatoblastoma
Preferred_Name: Hepatoblastoma
UMLS_CUI: C0206624
Contributing_Source: CDISC
Contributing_Source: CTEP
Contributing_Source: CTRP
Contributing_Source: MedDRA
Contributing_Source: NICHD
ALT_DEFINITION: A malignant liver neoplasm composed of immature hepatocytic elements.
ALT_DEFINITION: A malignant liver tumor that arises from precursors of hepatocytes. It occurs almost exclusively in infants. The lungs are the most common site of metastasis.
ALT_DEFINITION: A type of liver tumor that occurs in infants and children.
ICD-O-3_Code: 8970/3
Neoplastic_Status: Malignant
Legacy_Concept_Name: Hepatoblastoma
NICHD_Hierarchy_Term: Hepatoblastoma
has exact synonym: HBL
has exact synonym: HEPATOBLASTOMA, MALIGNANT
has exact synonym: Hepatoblastoma
has exact synonym: Pediatric Embryonal Hepatoma
has exact synonym: Pediatric Hepatoblastoma
has exact synonym: hepatoblastoma
in subset: oncotree slim

Axiom
annotated source: Hepatoblastoma
annotated property: definition
annotated target: A malignant liver neoplasm that occurs almost exclusively in infants, although isolated cases in older children and adults have been reported. Grossly, hepatoblastoma is solid, well circumscribed, and more often solitary than multiple. Microscopically, most of the tumors are composed exclusively of immature hepatocytic elements. About a fourth of hepatoblastomas contain a stromal component that may be undifferentiated or develop into bone or cartilage. The treatment of choice for hepatoblastoma is surgical excision with adjuvant therapy. Liver transplantation is being increasingly used as well.
def-source: NCI

Axiom
annotated source: Hepatoblastoma
annotated property: ALT_DEFINITION
annotated target: A malignant liver neoplasm composed of immature hepatocytic elements.
def-source: CDISC

Axiom
annotated source: Hepatoblastoma
annotated property: ALT_DEFINITION
annotated target: A malignant liver tumor that arises from precursors of hepatocytes. It occurs almost exclusively in infants. The lungs are the most common site of metastasis.
def-source: NICHD

Axiom
annotated source: Hepatoblastoma
annotated property: ALT_DEFINITION
annotated target: A type of liver tumor that occurs in infants and children.
def-source: NCI-GLOSS

Axiom
annotated source: Hepatoblastoma
annotated property: has exact synonym
annotated target: HBL
term-group: AB
term-source: NCI

Axiom
annotated source: Hepatoblastoma
annotated property: has exact synonym
annotated target: HBL
term-group: SY
term-source: CDISC

Axiom
annotated source: Hepatoblastoma
annotated property: has exact synonym
annotated target: HEPATOBLASTOMA, MALIGNANT
term-group: PT
term-source: CDISC

Axiom
annotated source: Hepatoblastoma
annotated property: has exact synonym
annotated target: Hepatoblastoma
term-group: DN
term-source: CTRP

Axiom
annotated source: Hepatoblastoma
annotated property: has exact synonym
annotated target: Hepatoblastoma
term-group: PT
term-source: CTEP
source-code: 10019822
subsource-name: SDC

Axiom
annotated source: Hepatoblastoma
annotated property: has exact synonym
annotated target: Hepatoblastoma
term-group: PT
term-source: CTRP

Axiom
annotated source: Hepatoblastoma
annotated property: has exact synonym
annotated target: Hepatoblastoma
term-group: PT
term-source: NCI

Axiom
annotated source: Hepatoblastoma
annotated property: has exact synonym
annotated target: Hepatoblastoma
term-group: PT
term-source: NICHD

Axiom
annotated source: Hepatoblastoma
annotated property: has exact synonym
annotated target: Pediatric Embryonal Hepatoma
term-group: SY
term-source: CDISC

Axiom
annotated source: Hepatoblastoma
annotated property: has exact synonym
annotated target: Pediatric Embryonal Hepatoma
term-group: SY
term-source: NCI

Axiom
annotated source: Hepatoblastoma
annotated property: has exact synonym
annotated target: Pediatric Hepatoblastoma
term-group: SY
term-source: CDISC

Axiom
annotated source: Hepatoblastoma
annotated property: has exact synonym
annotated target: Pediatric Hepatoblastoma
term-group: SY
term-source: NCI

Axiom
annotated source: Hepatoblastoma
annotated property: has exact synonym
annotated target: hepatoblastoma
term-group: PT
term-source: NCI-GLOSS
source-code: CDR0000046160

Mesenchymal Chondrosarcoma
type: Class
subclass of: Chondrosarcoma
definition: A morphologic variant of chondrosarcoma arising from bone and soft tissue. It is characterized by the presence of malignant small round cells, biphasic growth pattern, and well differentiated hyaline cartilage. Clinical presentation includes pain and swelling. The clinical course is aggressive, with local recurrences and distant metastases.
Concept_In_Subset: NCIT C126659
code: C3737
Semantic_Type: Neoplastic Process
Preferred_Name: Mesenchymal Chondrosarcoma
UMLS_CUI: C0206637
ICD-O-3_Code: 9240/3
Neoplastic_Status: Malignant
Legacy_Concept_Name: Mesenchymal_Chondrosarcoma
has exact synonym: Mesenchymal Chondrosarcoma
in subset: oncotree slim

Axiom
annotated source: Mesenchymal Chondrosarcoma
annotated property: definition
annotated target: A morphologic variant of chondrosarcoma arising from bone and soft tissue. It is characterized by the presence of malignant small round cells, biphasic growth pattern, and well differentiated hyaline cartilage. Clinical presentation includes pain and swelling. The clinical course is aggressive, with local recurrences and distant metastases.
def-source: NCI

Axiom
annotated source: Mesenchymal Chondrosarcoma
annotated property: has exact synonym
annotated target: Mesenchymal Chondrosarcoma
term-group: PT
term-source: NCI

Clear Cell Sarcoma of Soft Tissue
type: Class
definition: A rare malignant neoplasm with melanocytic differentiation characterized by the presence of polygonal or spindle shaped clear cells. This sarcoma usually affects the tendons and aponeuroses and is associated with a poor prognosis due to recurrences and metastases.
Concept_In_Subset: NCIT C102905
Concept_In_Subset: NCIT C103117
code: C3745
Semantic_Type: Neoplastic Process
Preferred_Name: Clear Cell Sarcoma of Soft Tissue
UMLS_CUI: C0206651
Contributing_Source: CTEP
ALT_DEFINITION: A soft tissue tumor that begins in a tendon (tough, fibrous, cord-like tissue that connects muscle to bone or to another structure). Clear cell sarcoma of soft tissue has certain markers that are also found on malignant melanoma (a type of skin cancer). It usually occurs in the leg or arm.
ICD-O-3_Code: 9044/3
Neoplastic_Status: Malignant
Legacy_Concept_Name: Clear_Cell_Sarcoma_of_Soft_Parts
has exact synonym: Chordoid Sarcoma
has exact synonym: Clear Cell Sarcoma of Soft Parts
has exact synonym: Clear Cell Sarcoma of Soft Tissue
has exact synonym: Clear cell sarcoma - not kidney
has exact synonym: Clear cell sarcoma/Malignant melanoma of soft parts (excluding Clear cell sarcoma of the kidney)
has exact synonym: Malignant Melanoma of Soft Parts
has exact synonym: Malignant Melanoma of the Soft Parts
has exact synonym: clear cell sarcoma of soft tissue
has exact synonym: malignant melanoma of soft parts
in subset: oncotree slim

Axiom
annotated source: Clear Cell Sarcoma of Soft Tissue
annotated property: definition
annotated target: A rare malignant neoplasm with melanocytic differentiation characterized by the presence of polygonal or spindle shaped clear cells. This sarcoma usually affects the tendons and aponeuroses and is associated with a poor prognosis due to recurrences and metastases.
def-source: NCI

Axiom
annotated source: Clear Cell Sarcoma of Soft Tissue
annotated property: ALT_DEFINITION
annotated target: A soft tissue tumor that begins in a tendon (tough, fibrous, cord-like tissue that connects muscle to bone or to another structure). Clear cell sarcoma of soft tissue has certain markers that are also found on malignant melanoma (a type of skin cancer). It usually occurs in the leg or arm.
def-source: NCI-GLOSS

Axiom
annotated source: Clear Cell Sarcoma of Soft Tissue
annotated property: has exact synonym
annotated target: Chordoid Sarcoma
term-group: SY
term-source: NCI

Axiom
annotated source: Clear Cell Sarcoma of Soft Tissue
annotated property: has exact synonym
annotated target: Clear Cell Sarcoma of Soft Parts
term-group: SY
term-source: NCI

Axiom
annotated source: Clear Cell Sarcoma of Soft Tissue
annotated property: has exact synonym
annotated target: Clear Cell Sarcoma of Soft Tissue
term-group: PT
term-source: NCI

Axiom
annotated source: Clear Cell Sarcoma of Soft Tissue
annotated property: has exact synonym
annotated target: Clear cell sarcoma - not kidney
term-group: SY
term-source: CTEP
source-code: 10065865
subsource-name: SDC

Axiom
annotated source: Clear Cell Sarcoma of Soft Tissue
annotated property: has exact synonym
annotated target: Clear cell sarcoma/Malignant melanoma of soft parts (excluding Clear cell sarcoma of the kidney)
term-group: PT
term-source: CTEP
source-code: 10065865
subsource-name: SDC

Axiom
annotated source: Clear Cell Sarcoma of Soft Tissue
annotated property: has exact synonym
annotated target: Malignant Melanoma of Soft Parts
term-group: SY
term-source: NCI

Axiom
annotated source: Clear Cell Sarcoma of Soft Tissue
annotated property: has exact synonym
annotated target: Malignant Melanoma of the Soft Parts
term-group: SY
term-source: NCI

Axiom
annotated source: Clear Cell Sarcoma of Soft Tissue
annotated property: has exact synonym
annotated target: clear cell sarcoma of soft tissue
term-group: PT
term-source: NCI-GLOSS
source-code: CDR0000641939

Axiom
annotated source: Clear Cell Sarcoma of Soft Tissue
annotated property: has exact synonym
annotated target: malignant melanoma of soft parts
term-group: PT
term-source: NCI-GLOSS
source-code: CDR0000656145

Alveolar Rhabdomyosarcoma
type: Class
subclass of: Rhabdomyosarcoma
definition: A rapidly growing malignant mesenchymal neoplasm. It is characterized by the presence of round cells with myoblastic differentiation and a fibrovascular stroma resembling an alveolar growth pattern. The tumor usually presents in the extremities.
Concept_In_Subset: NCIT C102905
Concept_In_Subset: NCIT C103118
Concept_In_Subset: NCIT C126659
code: C3749
Semantic_Type: Neoplastic Process
Preferred_Name: Alveolar Rhabdomyosarcoma
UMLS_CUI: C0206655
Contributing_Source: CTEP
ALT_DEFINITION: A soft tissue tumor that is most common in older children and teenagers. It begins in embryonic muscle cells (cells that develop into muscles in the body). It can occur at many places in the body, but usually occurs in the trunk, arms, or legs.
ICD-O-3_Code: 8920/3
Neoplastic_Status: Malignant
Legacy_Concept_Name: Alveolar_Rhabdomyosarcoma
has exact synonym: ARMS
has exact synonym: Alveolar Rhabdomyosarcoma
has exact synonym: Alveolar rhabdomyosarcoma
has exact synonym: Monomorphous Round Cell Rhabdomyosarcoma
has exact synonym: alveolar rhabdomyosarcoma
in subset: oncotree slim

Axiom
annotated source: Alveolar Rhabdomyosarcoma
annotated property: definition
annotated target: A rapidly growing malignant mesenchymal neoplasm. It is characterized by the presence of round cells with myoblastic differentiation and a fibrovascular stroma resembling an alveolar growth pattern. The tumor usually presents in the extremities.
def-source: NCI

Axiom
annotated source: Alveolar Rhabdomyosarcoma
annotated property: ALT_DEFINITION
annotated target: A soft tissue tumor that is most common in older children and teenagers. It begins in embryonic muscle cells (cells that develop into muscles in the body). It can occur at many places in the body, but usually occurs in the trunk, arms, or legs.
def-source: NCI-GLOSS

Axiom
annotated source: Alveolar Rhabdomyosarcoma
annotated property: has exact synonym
annotated target: ARMS
term-group: AB
term-source: NCI

Axiom
annotated source: Alveolar Rhabdomyosarcoma
annotated property: has exact synonym
annotated target: ARMS
term-group: PT
term-source: NCI-GLOSS
source-code: CDR0000641928

Axiom
annotated source: Alveolar Rhabdomyosarcoma
annotated property: has exact synonym
annotated target: Alveolar Rhabdomyosarcoma
term-group: PT
term-source: NCI

Axiom
annotated source: Alveolar Rhabdomyosarcoma
annotated property: has exact synonym
annotated target: Alveolar rhabdomyosarcoma
term-group: PT
term-source: CTEP
source-code: 10065867
subsource-name: SDC

Axiom
annotated source: Alveolar Rhabdomyosarcoma
annotated property: has exact synonym
annotated target: Monomorphous Round Cell Rhabdomyosarcoma
term-group: SY
term-source: NCI

Axiom
annotated source: Alveolar Rhabdomyosarcoma
annotated property: has exact synonym
annotated target: alveolar rhabdomyosarcoma
term-group: PT
term-source: NCI-GLOSS
source-code: CDR0000641927

Alveolar Soft Part Sarcoma
type: Class
definition: A rare malignant neoplasm characterized by the presence of large epithelioid cells with abundant cytoplasm forming nests and pseudoalveolar structures. The groups of the epithelioid cells are separated by thin-walled sinusoidal spaces. It occurs most often in adolescents and young adults. In adults the most common sites of involvement are the extremities, and in infants and children, the head and neck. It usually presents as a slowly growing mass and it frequently metastasizes to other anatomic sites. The most common sites of metastasis are the lungs, bone, and brain.
Concept_In_Subset: NCIT C102905
Concept_In_Subset: NCIT C103117
code: C3750
Semantic_Type: Neoplastic Process
Preferred_Name: Alveolar Soft Part Sarcoma
UMLS_CUI: C0206657
Contributing_Source: CTEP
ALT_DEFINITION: A soft tissue tumor that is most common in older children and teenagers. It begins in the soft supporting tissue that connects and surrounds the organs and other tissues. Alveolar soft part sarcoma usually occurs in the legs, but can also occur in the arms, hands, head, or neck. It can cause the growth of new blood vessels that help the tumor grow and spread.
ICD-O-3_Code: 9581/3
Neoplastic_Status: Malignant
Legacy_Concept_Name: Alveolar_Soft_Part_Sarcoma
has exact synonym: ASPS
has exact synonym: Alveolar Soft Part Sarcoma
has exact synonym: Alveolar soft part sarcoma
has exact synonym: alveolar soft part sarcoma
in subset: oncotree slim

Axiom
annotated source: Alveolar Soft Part Sarcoma
annotated property: definition
annotated target: A rare malignant neoplasm characterized by the presence of large epithelioid cells with abundant cytoplasm forming nests and pseudoalveolar structures. The groups of the epithelioid cells are separated by thin-walled sinusoidal spaces. It occurs most often in adolescents and young adults. In adults the most common sites of involvement are the extremities, and in infants and children, the head and neck. It usually presents as a slowly growing mass and it frequently metastasizes to other anatomic sites. The most common sites of metastasis are the lungs, bone, and brain.
def-source: NCI

Axiom
annotated source: Alveolar Soft Part Sarcoma
annotated property: ALT_DEFINITION
annotated target: A soft tissue tumor that is most common in older children and teenagers. It begins in the soft supporting tissue that connects and surrounds the organs and other tissues. Alveolar soft part sarcoma usually occurs in the legs, but can also occur in the arms, hands, head, or neck. It can cause the growth of new blood vessels that help the tumor grow and spread.
def-source: NCI-GLOSS

Axiom
annotated source: Alveolar Soft Part Sarcoma
annotated property: has exact synonym
annotated target: ASPS
term-group: AB
term-source: NCI

Axiom
annotated source: Alveolar Soft Part Sarcoma
annotated property: has exact synonym
annotated target: ASPS
term-group: PT
term-source: NCI-GLOSS
source-code: CDR0000641934

Axiom
annotated source: Alveolar Soft Part Sarcoma
annotated property: has exact synonym
annotated target: Alveolar Soft Part Sarcoma
term-group: DN
term-source: CTRP

Axiom
annotated source: Alveolar Soft Part Sarcoma
annotated property: has exact synonym
annotated target: Alveolar Soft Part Sarcoma
term-group: PT
term-source: NCI

Axiom
annotated source: Alveolar Soft Part Sarcoma
annotated property: has exact synonym
annotated target: Alveolar soft part sarcoma
term-group: PT
term-source: CTEP
source-code: 10001886
subsource-name: SDC

Axiom
annotated source: Alveolar Soft Part Sarcoma
annotated property: has exact synonym
annotated target: alveolar soft part sarcoma
term-group: PT
term-source: NCI-GLOSS
source-code: CDR0000641933

Embryonal Carcinoma
type: Class
definition: A non-seminomatous malignant germ cell tumor characterized by the presence of large germ cells with abundant cytoplasm resembling epithelial cells, geographic necrosis, high mitotic activity, and pseudoglandular and pseudopapillary structures formation. It can arise from the testis, ovary, and extragonadal sites (central nervous system and mediastinum).
Concept_In_Subset: NCIT C126659
Concept_In_Subset: NCIT C61410
Concept_In_Subset: NCIT C77526
Concept_In_Subset: NCIT C88025
code: C3752
Semantic_Type: Neoplastic Process
Preferred_Name: Embryonal Carcinoma
UMLS_CUI: C0206659
Contributing_Source: CDISC
ALT_DEFINITION: A non-seminomatous malignant germ cell neoplasm of the testis or ovary.
ICD-O-3_Code: 9070/3
Neoplastic_Status: Malignant
Legacy_Concept_Name: Embryonal_Carcinoma
has exact synonym: CARCINOMA, EMBRYONAL, MALIGNANT
has exact synonym: Carcinoma, Embryonal, Malignant
has exact synonym: Embryonal Carcinoma
in subset: oncotree slim

Axiom
annotated source: Embryonal Carcinoma
annotated property: definition
annotated target: A non-seminomatous malignant germ cell tumor characterized by the presence of large germ cells with abundant cytoplasm resembling epithelial cells, geographic necrosis, high mitotic activity, and pseudoglandular and pseudopapillary structures formation. It can arise from the testis, ovary, and extragonadal sites (central nervous system and mediastinum).
def-source: NCI

Axiom
annotated source: Embryonal Carcinoma
annotated property: ALT_DEFINITION
annotated target: A non-seminomatous malignant germ cell neoplasm of the testis or ovary.
def-source: CDISC

Axiom
annotated source: Embryonal Carcinoma
annotated property: has exact synonym
annotated target: CARCINOMA, EMBRYONAL, MALIGNANT
term-group: PT
term-source: CDISC

Axiom
annotated source: Embryonal Carcinoma
annotated property: has exact synonym
annotated target: Carcinoma, Embryonal, Malignant
term-group: SY
term-source: CDISC

Axiom
annotated source: Embryonal Carcinoma
annotated property: has exact synonym
annotated target: Embryonal Carcinoma
term-group: DN
term-source: CTRP

Axiom
annotated source: Embryonal Carcinoma
annotated property: has exact synonym
annotated target: Embryonal Carcinoma
term-group: PT
term-source: CTRP

Axiom
annotated source: Embryonal Carcinoma
annotated property: has exact synonym
annotated target: Embryonal Carcinoma
term-group: PT
term-source: NCI

Axiom
annotated source: Embryonal Carcinoma
annotated property: has exact synonym
annotated target: Embryonal Carcinoma
term-group: SY
term-source: NCI
source-code: TCGA
subsource-name: caDSR

Germinoma
type: Class
definition: A malignant germ cell tumor arising in the central nervous system. It is characterized by the presence of primitive, large malignant germ cells and lymphocytes.
Has_NICHD_Parent: NCIT C3708
Concept_In_Subset: NCIT C118467
Concept_In_Subset: NCIT C126659
Concept_In_Subset: NCIT C90259
code: C3753
Semantic_Type: Neoplastic Process
Preferred_Name: Germinoma
UMLS_CUI: C0206660
Contributing_Source: NICHD
ALT_DEFINITION: A germinomatous germ cell tumor arising in the central nervous system; it is histologically identical to the dysgerminoma and seminoma.
ICD-O-3_Code: 9064/3
Neoplastic_Status: Malignant
Legacy_Concept_Name: Germinoma
NICHD_Hierarchy_Term: Germinoma
has exact synonym: Germinoma
in subset: oncotree slim

Axiom
annotated source: Germinoma
annotated property: definition
annotated target: A malignant germ cell tumor arising in the central nervous system. It is characterized by the presence of primitive, large malignant germ cells and lymphocytes.
def-source: NCI

Axiom
annotated source: Germinoma
annotated property: ALT_DEFINITION
annotated target: A germinomatous germ cell tumor arising in the central nervous system; it is histologically identical to the dysgerminoma and seminoma.
def-source: NICHD

Axiom
annotated source: Germinoma
annotated property: has exact synonym
annotated target: Germinoma
term-group: DN
term-source: CTRP

Axiom
annotated source: Germinoma
annotated property: has exact synonym
annotated target: Germinoma
term-group: PT
term-source: CTRP

Axiom
annotated source: Germinoma
annotated property: has exact synonym
annotated target: Germinoma
term-group: PT
term-source: NCI

Axiom
annotated source: Germinoma
annotated property: has exact synonym
annotated target: Germinoma
term-group: PT
term-source: NICHD

Axiom
annotated source: Germinoma
annotated property: has exact synonym
annotated target: Germinoma
term-group: SY
term-source: NCI
source-code: TCGA
subsource-name: caDSR

Placental-Site Gestational Trophoblastic Tumor
type: Class
subclass of: Gestational Trophoblastic Tumor
definition: A rare gestational trophoblastic tumor characterized by the presence of a diffuse cellular infiltrate composed of intermediate trophoblasts and cytotrophoblasts and by the absense of a significant population of syncytiotrophoblasts.
code: C3757
Semantic_Type: Neoplastic Process
Preferred_Name: Placental-Site Gestational Trophoblastic Tumor
UMLS_CUI: C0206666
ICD-O-3_Code: 9104/1
Neoplastic_Status: Undetermined
Legacy_Concept_Name: Placental-Site_Gestational_Trophoblastic_Tumor
has exact synonym: Placental Site Gestational Trophoblastic Tumor
has exact synonym: Placental-Site GTT
has exact synonym: Placental-Site Gestational Trophoblastic Neoplasm
has exact synonym: Placental-Site Gestational Trophoblastic Tumor
in subset: oncotree slim

Axiom
annotated source: Placental-Site Gestational Trophoblastic Tumor
annotated property: definition
annotated target: A rare gestational trophoblastic tumor characterized by the presence of a diffuse cellular infiltrate composed of intermediate trophoblasts and cytotrophoblasts and by the absense of a significant population of syncytiotrophoblasts.
def-source: NCI

Axiom
annotated source: Placental-Site Gestational Trophoblastic Tumor
annotated property: has exact synonym
annotated target: Placental Site Gestational Trophoblastic Tumor
term-group: SY
term-source: NCI

Axiom
annotated source: Placental-Site Gestational Trophoblastic Tumor
annotated property: has exact synonym
annotated target: Placental-Site GTT
term-group: SY
term-source: NCI

Axiom
annotated source: Placental-Site Gestational Trophoblastic Tumor
annotated property: has exact synonym
annotated target: Placental-Site Gestational Trophoblastic Neoplasm
term-group: SY
term-source: NCI

Axiom
annotated source: Placental-Site Gestational Trophoblastic Tumor
annotated property: has exact synonym
annotated target: Placental-Site Gestational Trophoblastic Tumor
term-group: PT
term-source: NCI

Hepatocellular Adenoma
type: Class
definition: A benign epithelial neoplasm arising from the hepatocytes. Grossly, it appears as a soft, round mass which often contains areas of hemorrhage and necrosis. Morphologically, the neoplastic cells resemble normal hepatocytes and form plates separated by sinusoids. Most patients have a history of contraceptive or anabolic steroids use.
Concept_In_Subset: NCIT C126659
Concept_In_Subset: NCIT C61410
Concept_In_Subset: NCIT C77526
Concept_In_Subset: NCIT C88025
code: C3758
Semantic_Type: Neoplastic Process
Preferred_Name: Hepatocellular Adenoma
UMLS_CUI: C0206669
Contributing_Source: CDISC
ALT_DEFINITION: A benign epithelial neoplasm arising from hepatocytes.
ICD-O-3_Code: 8170/0
Neoplastic_Status: Benign
Legacy_Concept_Name: Hepatocellular_Adenoma
has exact synonym: ADENOMA, HEPATOCELLULAR, BENIGN
has exact synonym: Adenoma of Liver Cells
has exact synonym: Adenoma of the Liver Cells
has exact synonym: HCA
has exact synonym: Hepatocellular Adenoma
has exact synonym: Liver Cell Adenoma
in subset: oncotree slim

Axiom
annotated source: Hepatocellular Adenoma
annotated property: definition
annotated target: A benign epithelial neoplasm arising from the hepatocytes. Grossly, it appears as a soft, round mass which often contains areas of hemorrhage and necrosis. Morphologically, the neoplastic cells resemble normal hepatocytes and form plates separated by sinusoids. Most patients have a history of contraceptive or anabolic steroids use.
def-source: NCI

Axiom
annotated source: Hepatocellular Adenoma
annotated property: ALT_DEFINITION
annotated target: A benign epithelial neoplasm arising from hepatocytes.
def-source: CDISC

Axiom
annotated source: Hepatocellular Adenoma
annotated property: has exact synonym
annotated target: ADENOMA, HEPATOCELLULAR, BENIGN
term-group: PT
term-source: CDISC

Axiom
annotated source: Hepatocellular Adenoma
annotated property: has exact synonym
annotated target: Adenoma of Liver Cells
term-group: SY
term-source: CDISC

Axiom
annotated source: Hepatocellular Adenoma
annotated property: has exact synonym
annotated target: Adenoma of Liver Cells
term-group: SY
term-source: NCI

Axiom
annotated source: Hepatocellular Adenoma
annotated property: has exact synonym
annotated target: Adenoma of the Liver Cells
term-group: SY
term-source: CDISC

Axiom
annotated source: Hepatocellular Adenoma
annotated property: has exact synonym
annotated target: Adenoma of the Liver Cells
term-group: SY
term-source: NCI

Axiom
annotated source: Hepatocellular Adenoma
annotated property: has exact synonym
annotated target: HCA
term-group: AB
term-source: NCI

Axiom
annotated source: Hepatocellular Adenoma
annotated property: has exact synonym
annotated target: HCA
term-group: SY
term-source: CDISC

Axiom
annotated source: Hepatocellular Adenoma
annotated property: has exact synonym
annotated target: Hepatocellular Adenoma
term-group: PT
term-source: NCI

Axiom
annotated source: Hepatocellular Adenoma
annotated property: has exact synonym
annotated target: Liver Cell Adenoma
term-group: SY
term-source: CDISC

Axiom
annotated source: Hepatocellular Adenoma
annotated property: has exact synonym
annotated target: Liver Cell Adenoma
term-group: SY
term-source: NCI

Acinar Cell Carcinoma
type: Class
definition: A malignant glandular epithelial neoplasm consisting of secretory cells forming acinar patterns. Representative examples include the acinar cell carcinoma of the pancreas and the acinar adenocarcinoma of the prostate gland.
Concept_In_Subset: NCIT C126659
Concept_In_Subset: NCIT C61410
Concept_In_Subset: NCIT C77526
Concept_In_Subset: NCIT C88025
code: C3768
Semantic_Type: Neoplastic Process
Preferred_Name: Acinar Cell Carcinoma
UMLS_CUI: C0206685
Contributing_Source: CDISC
ALT_DEFINITION: A malignant glandular epithelial neoplasm comprising secretory cells forming acinar patterns.
ICD-O-3_Code: 8550/3
Neoplastic_Status: Malignant
Legacy_Concept_Name: Acinar_Cell_Carcinoma
has exact synonym: Acinar Adenocarcinoma
has exact synonym: Acinar Carcinoma
has exact synonym: Acinar Cell Adenocarcinoma
has exact synonym: Acinar Cell Carcinoma
has exact synonym: Acinic Cell Adenocarcinoma
has exact synonym: Acinic Cell Carcinoma
has exact synonym: CARCINOMA, ACINAR CELL, MALIGNANT
in subset: oncotree slim

Axiom
annotated source: Acinar Cell Carcinoma
annotated property: definition
annotated target: A malignant glandular epithelial neoplasm consisting of secretory cells forming acinar patterns. Representative examples include the acinar cell carcinoma of the pancreas and the acinar adenocarcinoma of the prostate gland.
def-source: NCI

Axiom
annotated source: Acinar Cell Carcinoma
annotated property: ALT_DEFINITION
annotated target: A malignant glandular epithelial neoplasm comprising secretory cells forming acinar patterns.
def-source: CDISC

Axiom
annotated source: Acinar Cell Carcinoma
annotated property: has exact synonym
annotated target: Acinar Adenocarcinoma
term-group: SY
term-source: CDISC

Axiom
annotated source: Acinar Cell Carcinoma
annotated property: has exact synonym
annotated target: Acinar Adenocarcinoma
term-group: SY
term-source: NCI

Axiom
annotated source: Acinar Cell Carcinoma
annotated property: has exact synonym
annotated target: Acinar Carcinoma
term-group: SY
term-source: CDISC

Axiom
annotated source: Acinar Cell Carcinoma
annotated property: has exact synonym
annotated target: Acinar Carcinoma
term-group: SY
term-source: NCI

Axiom
annotated source: Acinar Cell Carcinoma
annotated property: has exact synonym
annotated target: Acinar Cell Adenocarcinoma
term-group: SY
term-source: CDISC

Axiom
annotated source: Acinar Cell Carcinoma
annotated property: has exact synonym
annotated target: Acinar Cell Adenocarcinoma
term-group: SY
term-source: NCI

Axiom
annotated source: Acinar Cell Carcinoma
annotated property: has exact synonym
annotated target: Acinar Cell Carcinoma
term-group: PT
term-source: NCI

Axiom
annotated source: Acinar Cell Carcinoma
annotated property: has exact synonym
annotated target: Acinar Cell Carcinoma
term-group: SY
term-source: NCI
source-code: TCGA
subsource-name: caDSR

Axiom
annotated source: Acinar Cell Carcinoma
annotated property: has exact synonym
annotated target: Acinic Cell Adenocarcinoma
term-group: SY
term-source: CDISC

Axiom
annotated source: Acinar Cell Carcinoma
annotated property: has exact synonym
annotated target: Acinic Cell Adenocarcinoma
term-group: SY
term-source: NCI

Axiom
annotated source: Acinar Cell Carcinoma
annotated property: has exact synonym
annotated target: Acinic Cell Carcinoma
term-group: SY
term-source: CDISC

Axiom
annotated source: Acinar Cell Carcinoma
annotated property: has exact synonym
annotated target: Acinic Cell Carcinoma
term-group: SY
term-source: NCI

Axiom
annotated source: Acinar Cell Carcinoma
annotated property: has exact synonym
annotated target: CARCINOMA, ACINAR CELL, MALIGNANT
term-group: PT
term-source: CDISC

Endometrioid Adenocarcinoma
type: Class
definition: An adenocarcinoma characterized by the presence of malignant glandular epithelial cells resembling endometrial cells. It can arise from the uterine body, ovary, fallopian tube, cervix, vagina, and uterine ligament.
code: C3769
Semantic_Type: Neoplastic Process
Preferred_Name: Endometrioid Adenocarcinoma
UMLS_CUI: C0206687
ICD-O-3_Code: 8380/3
Neoplastic_Status: Malignant
Legacy_Concept_Name: Endometrioid_Carcinoma
has exact synonym: Endometrioid Adenocarcinoma
has exact synonym: Endometrioid Carcinoma
has exact synonym: Endometrioid Carcinoma of Female Reproductive System
has exact synonym: Endometrioid Carcinoma of the Female Reproductive System
has exact synonym: Female Reproductive Endometrioid Carcinoma
in subset: oncotree slim

Axiom
annotated source: Endometrioid Adenocarcinoma
annotated property: definition
annotated target: An adenocarcinoma characterized by the presence of malignant glandular epithelial cells resembling endometrial cells. It can arise from the uterine body, ovary, fallopian tube, cervix, vagina, and uterine ligament.
def-source: NCI

Axiom
annotated source: Endometrioid Adenocarcinoma
annotated property: has exact synonym
annotated target: Endometrioid Adenocarcinoma
term-group: PT
term-source: NCI

Axiom
annotated source: Endometrioid Adenocarcinoma
annotated property: has exact synonym
annotated target: Endometrioid Adenocarcinoma
term-group: SY
term-source: NCI
source-code: TCGA
subsource-name: caDSR

Axiom
annotated source: Endometrioid Adenocarcinoma
annotated property: has exact synonym
annotated target: Endometrioid Carcinoma
term-group: SY
term-source: NCI

Axiom
annotated source: Endometrioid Adenocarcinoma
annotated property: has exact synonym
annotated target: Endometrioid Carcinoma of Female Reproductive System
term-group: SY
term-source: NCI

Axiom
annotated source: Endometrioid Adenocarcinoma
annotated property: has exact synonym
annotated target: Endometrioid Carcinoma of the Female Reproductive System
term-group: SY
term-source: NCI

Axiom
annotated source: Endometrioid Adenocarcinoma
annotated property: has exact synonym
annotated target: Female Reproductive Endometrioid Carcinoma
term-group: SY
term-source: NCI

Mucoepidermoid Carcinoma
type: Class
definition: A carcinoma morphologically characterized the presence of cuboidal mucous cells, goblet-like mucous cells, squamoid cells, cystic changes, and a fibrotic stromal formation. It can occur in several anatomic sites, including parotid gland, oral cavity, paranasal sinus, skin, breast, lung, larynx, and lacrimal ducts. It is classified as low or high grade.
code: C3772
Semantic_Type: Neoplastic Process
Preferred_Name: Mucoepidermoid Carcinoma
UMLS_CUI: C0206694
ICD-O-3_Code: 8430/1
ICD-O-3_Code: 8430/3
Neoplastic_Status: Malignant
Legacy_Concept_Name: Mucoepidermoid_Carcinoma
has exact synonym: MEC
has exact synonym: Mucoepidermoid Carcinoma
in subset: oncotree slim

Axiom
annotated source: Mucoepidermoid Carcinoma
annotated property: definition
annotated target: A carcinoma morphologically characterized the presence of cuboidal mucous cells, goblet-like mucous cells, squamoid cells, cystic changes, and a fibrotic stromal formation. It can occur in several anatomic sites, including parotid gland, oral cavity, paranasal sinus, skin, breast, lung, larynx, and lacrimal ducts. It is classified as low or high grade.
def-source: NCI

Axiom
annotated source: Mucoepidermoid Carcinoma
annotated property: has exact synonym
annotated target: MEC
term-group: AB
term-source: NCI

Axiom
annotated source: Mucoepidermoid Carcinoma
annotated property: has exact synonym
annotated target: Mucoepidermoid Carcinoma
term-group: PT
term-source: NCI

Axiom
annotated source: Mucoepidermoid Carcinoma
annotated property: has exact synonym
annotated target: Mucoepidermoid Carcinoma
term-group: SY
term-source: NCI
source-code: TCGA
subsource-name: caDSR

Adnexal Carcinoma
type: Class
definition: A carcinoma arising from the sebaceous glands, sweat glands, or the hair follicles. Representative examples include sebaceous carcinoma, apocrine carcinoma, eccrine carcinoma, and pilomatrical carcinoma.
Concept_In_Subset: NCIT C126659
Concept_In_Subset: NCIT C61410
Concept_In_Subset: NCIT C77526
Concept_In_Subset: NCIT C88025
code: C3775
Semantic_Type: Neoplastic Process
Preferred_Name: Adnexal Carcinoma
UMLS_CUI: C0206697
Contributing_Source: CDISC
ALT_DEFINITION: A malignant epithelial neoplasm arising from sebaceous or sweat glands or from hair follicles.
ICD-O-3_Code: 8390/3
Neoplastic_Status: Malignant
Legacy_Concept_Name: Adnexal_Carcinoma
has exact synonym: Adnexal Carcinoma
has exact synonym: CARCINOMA, ADNEXAL, MALIGNANT
has exact synonym: Carcinoma of Adnexa
has exact synonym: Carcinoma of Skin Appendage
has exact synonym: Skin Appendage Carcinoma
in subset: oncotree slim

Axiom
annotated source: Adnexal Carcinoma
annotated property: definition
annotated target: A carcinoma arising from the sebaceous glands, sweat glands, or the hair follicles. Representative examples include sebaceous carcinoma, apocrine carcinoma, eccrine carcinoma, and pilomatrical carcinoma.
def-source: NCI

Axiom
annotated source: Adnexal Carcinoma
annotated property: ALT_DEFINITION
annotated target: A malignant epithelial neoplasm arising from sebaceous or sweat glands or from hair follicles.
def-source: CDISC

Axiom
annotated source: Adnexal Carcinoma
annotated property: has exact synonym
annotated target: Adnexal Carcinoma
term-group: PT
term-source: NCI

Axiom
annotated source: Adnexal Carcinoma
annotated property: has exact synonym
annotated target: CARCINOMA, ADNEXAL, MALIGNANT
term-group: PT
term-source: CDISC

Axiom
annotated source: Adnexal Carcinoma
annotated property: has exact synonym
annotated target: Carcinoma of Adnexa
term-group: SY
term-source: CDISC

Axiom
annotated source: Adnexal Carcinoma
annotated property: has exact synonym
annotated target: Carcinoma of Adnexa
term-group: SY
term-source: NCI

Axiom
annotated source: Adnexal Carcinoma
annotated property: has exact synonym
annotated target: Carcinoma of Skin Appendage
term-group: SY
term-source: CDISC

Axiom
annotated source: Adnexal Carcinoma
annotated property: has exact synonym
annotated target: Carcinoma of Skin Appendage
term-group: SY
term-source: NCI

Axiom
annotated source: Adnexal Carcinoma
annotated property: has exact synonym
annotated target: Skin Appendage Carcinoma
term-group: SY
term-source: CDISC

Axiom
annotated source: Adnexal Carcinoma
annotated property: has exact synonym
annotated target: Skin Appendage Carcinoma
term-group: SY
term-source: NCI

Neuroepithelial Neoplasm
type: Class
definition: A neoplasm of the nervous system that arises from the neuroepithelial tissues. Representative examples include astrocytic tumors, oligodendroglial tumors, ependymal tumors, and primitive neuroectodermal tumors.
code: C3787
Semantic_Type: Neoplastic Process
Preferred_Name: Neuroepithelial Neoplasm
UMLS_CUI: C0206715
Neoplastic_Status: Undetermined
Legacy_Concept_Name: Neuroepithelial_Neoplasm
has exact synonym: Neoplasm of Neuroepithelial Tissue
has exact synonym: Neoplasm of Neuroepithelium
has exact synonym: Neoplasm of the Neuroepithelium
has exact synonym: Neuroepithelial Neoplasm
has exact synonym: Neuroepithelial Neoplasms
has exact synonym: Neuroepithelial Tissue Neoplasm
has exact synonym: Neuroepithelial Tissue Tumor
has exact synonym: Neuroepithelial Tumor
has exact synonym: Neuroepithelial Tumors
has exact synonym: Tumor of Neuroepithelial Tissue
has exact synonym: Tumor of Neuroepithelium
has exact synonym: Tumor of the Neuroepithelium
in subset: oncotree slim

Axiom
annotated source: Neuroepithelial Neoplasm
annotated property: definition
annotated target: A neoplasm of the nervous system that arises from the neuroepithelial tissues. Representative examples include astrocytic tumors, oligodendroglial tumors, ependymal tumors, and primitive neuroectodermal tumors.
def-source: NCI

Axiom
annotated source: Neuroepithelial Neoplasm
annotated property: has exact synonym
annotated target: Neoplasm of Neuroepithelial Tissue
term-group: SY
term-source: NCI

Axiom
annotated source: Neuroepithelial Neoplasm
annotated property: has exact synonym
annotated target: Neoplasm of Neuroepithelium
term-group: SY
term-source: NCI

Axiom
annotated source: Neuroepithelial Neoplasm
annotated property: has exact synonym
annotated target: Neoplasm of the Neuroepithelium
term-group: SY
term-source: NCI

Axiom
annotated source: Neuroepithelial Neoplasm
annotated property: has exact synonym
annotated target: Neuroepithelial Neoplasm
term-group: PT
term-source: NCI

Axiom
annotated source: Neuroepithelial Neoplasm
annotated property: has exact synonym
annotated target: Neuroepithelial Neoplasms
term-group: SY
term-source: NCI

Axiom
annotated source: Neuroepithelial Neoplasm
annotated property: has exact synonym
annotated target: Neuroepithelial Tissue Neoplasm
term-group: SY
term-source: NCI

Axiom
annotated source: Neuroepithelial Neoplasm
annotated property: has exact synonym
annotated target: Neuroepithelial Tissue Tumor
term-group: SY
term-source: NCI

Axiom
annotated source: Neuroepithelial Neoplasm
annotated property: has exact synonym
annotated target: Neuroepithelial Tumor
term-group: SY
term-source: NCI

Axiom
annotated source: Neuroepithelial Neoplasm
annotated property: has exact synonym
annotated target: Neuroepithelial Tumors
term-group: SY
term-source: NCI

Axiom
annotated source: Neuroepithelial Neoplasm
annotated property: has exact synonym
annotated target: Tumor of Neuroepithelial Tissue
term-group: SY
term-source: NCI

Axiom
annotated source: Neuroepithelial Neoplasm
annotated property: has exact synonym
annotated target: Tumor of Neuroepithelium
term-group: SY
term-source: NCI

Axiom
annotated source: Neuroepithelial Neoplasm
annotated property: has exact synonym
annotated target: Tumor of the Neuroepithelium
term-group: SY
term-source: NCI

Ganglioglioma
type: Class
definition: A well differentiated, slow growing neuroepithelial neoplasm composed of neoplastic, mature ganglion cells and neoplastic glial cells. Some gangliogliomas show anaplastic features in their glial component and are considered to be WHO grade III. Rare cases of newly diagnosed gangliogliomas with grade IV (glioblastoma) changes in the glial component have also been reported. (Adapted from WHO)
Concept_In_Subset: NCIT C126659
code: C3788
Semantic_Type: Neoplastic Process
Preferred_Name: Ganglioglioma
UMLS_CUI: C0206716
ICD-O-3_Code: 9505/1
Neoplastic_Status: Undetermined
Legacy_Concept_Name: Ganglioglioma
has exact synonym: Ganglioglioma
in subset: oncotree slim

Axiom
annotated source: Ganglioglioma
annotated property: definition
annotated target: A well differentiated, slow growing neuroepithelial neoplasm composed of neoplastic, mature ganglion cells and neoplastic glial cells. Some gangliogliomas show anaplastic features in their glial component and are considered to be WHO grade III. Rare cases of newly diagnosed gangliogliomas with grade IV (glioblastoma) changes in the glial component have also been reported. (Adapted from WHO)
def-source: NCI

Axiom
annotated source: Ganglioglioma
annotated property: has exact synonym
annotated target: Ganglioglioma
term-group: PT
term-source: NCI

Axiom
annotated source: Ganglioglioma
annotated property: has exact synonym
annotated target: Ganglioglioma
term-group: SY
term-source: NCI
source-code: TCGA
subsource-name: caDSR

Olfactory Neuroblastoma
type: Class
definition: A rare neuroectodermal tumor originating from olfactory receptor cells in the nasal cavity or paranasal sinuses. Microscopically, it is characterized by neuroblastic differentiation with occasional formation of rosettes. If the tumor is not resected at an early stage, the prognosis is usually poor.
Concept_In_Subset: NCIT C116977
Concept_In_Subset: NCIT C126659
code: C3789
Semantic_Type: Neoplastic Process
Display_Name: Olfactory Neuroblastoma
Preferred_Name: Olfactory Neuroblastoma
UMLS_CUI: C0206717
Contributing_Source: CDISC
Contributing_Source: CTRP
ICD-O-3_Code: 9522/3
ICD-O-3_Code: 9523/3
Neoplastic_Status: Malignant
Legacy_Concept_Name: Olfactory_Neuroblastoma
has exact synonym: Esthesioneuroblastoma
has exact synonym: Esthesioneuroepithelioma
has exact synonym: Olfactory Esthesioneuroblastoma
has exact synonym: Olfactory Neuroblastoma
has exact synonym: Olfactory Neuroepithelioma
in subset: oncotree slim

Axiom
annotated source: Olfactory Neuroblastoma
annotated property: definition
annotated target: A rare neuroectodermal tumor originating from olfactory receptor cells in the nasal cavity or paranasal sinuses. Microscopically, it is characterized by neuroblastic differentiation with occasional formation of rosettes. If the tumor is not resected at an early stage, the prognosis is usually poor.
def-source: NCI

Axiom
annotated source: Olfactory Neuroblastoma
annotated property: has exact synonym
annotated target: Esthesioneuroblastoma
term-group: SY
term-source: NCI

Axiom
annotated source: Olfactory Neuroblastoma
annotated property: has exact synonym
annotated target: Esthesioneuroepithelioma
term-group: SY
term-source: NCI

Axiom
annotated source: Olfactory Neuroblastoma
annotated property: has exact synonym
annotated target: Olfactory Esthesioneuroblastoma
term-group: SY
term-source: NCI

Axiom
annotated source: Olfactory Neuroblastoma
annotated property: has exact synonym
annotated target: Olfactory Neuroblastoma
term-group: PT
term-source: NCI

Axiom
annotated source: Olfactory Neuroblastoma
annotated property: has exact synonym
annotated target: Olfactory Neuroepithelioma
term-group: SY
term-source: NCI

Ganglioneuroblastoma
type: Class
definition: A neuroblastic tumor characterized by the presence of neuroblastic cells, ganglion cells, and a stroma with Schwannian differentiation constituting more than fifty-percent of the tumor volume. There are two histologic subtypes identified: ganglioneuroblastoma, intermixed and ganglioneuroblastoma, nodular.
Concept_In_Subset: NCIT C116977
Concept_In_Subset: NCIT C126659
Concept_In_Subset: NCIT C61410
Concept_In_Subset: NCIT C77526
Concept_In_Subset: NCIT C88025
code: C3790
Semantic_Type: Neoplastic Process
Display_Name: Ganglioneuroblastoma
Preferred_Name: Ganglioneuroblastoma
UMLS_CUI: C0206718
Contributing_Source: CDISC
ALT_DEFINITION: A malignant neoplasm characterized by the presence of neuroblastic and ganglion cells and a stroma with Schwannian differentiation.
ICD-O-3_Code: 9490/3
Neoplastic_Status: Malignant
Legacy_Concept_Name: Ganglioneuroblastoma
has exact synonym: GANGLIONEUROBLASTOMA, MALIGNANT
has exact synonym: Ganglioneuroblastoma
in subset: oncotree slim

Axiom
annotated source: Ganglioneuroblastoma
annotated property: definition
annotated target: A neuroblastic tumor characterized by the presence of neuroblastic cells, ganglion cells, and a stroma with Schwannian differentiation constituting more than fifty-percent of the tumor volume. There are two histologic subtypes identified: ganglioneuroblastoma, intermixed and ganglioneuroblastoma, nodular.
def-source: NCI

Axiom
annotated source: Ganglioneuroblastoma
annotated property: ALT_DEFINITION
annotated target: A malignant neoplasm characterized by the presence of neuroblastic and ganglion cells and a stroma with Schwannian differentiation.
def-source: CDISC

Axiom
annotated source: Ganglioneuroblastoma
annotated property: has exact synonym
annotated target: GANGLIONEUROBLASTOMA, MALIGNANT
term-group: PT
term-source: CDISC

Axiom
annotated source: Ganglioneuroblastoma
annotated property: has exact synonym
annotated target: Ganglioneuroblastoma
term-group: PT
term-source: CTRP

Axiom
annotated source: Ganglioneuroblastoma
annotated property: has exact synonym
annotated target: Ganglioneuroblastoma
term-group: PT
term-source: NCI

Central Neurocytoma
type: Class
definition: An intraventricular neuronal neoplasm composed of uniform round cells with neuronal differentiation. It is typically located in the lateral ventricles in the region of the foramen of Monro. It generally affects young adults and has a favorable prognosis. (Adapted from WHO)
Concept_In_Subset: NCIT C126659
code: C3791
Semantic_Type: Neoplastic Process
Preferred_Name: Central Neurocytoma
UMLS_CUI: C0206719
ICD-O-3_Code: 9506/1
Neoplastic_Status: Undetermined
Legacy_Concept_Name: Neurocytoma
has exact synonym: Central Neurocytoma
has exact synonym: Central Neurocytoma (WHO Grade II)
in subset: oncotree slim

Axiom
annotated source: Central Neurocytoma
annotated property: definition
annotated target: An intraventricular neuronal neoplasm composed of uniform round cells with neuronal differentiation. It is typically located in the lateral ventricles in the region of the foramen of Monro. It generally affects young adults and has a favorable prognosis. (Adapted from WHO)
def-source: NCI

Axiom
annotated source: Central Neurocytoma
annotated property: has exact synonym
annotated target: Central Neurocytoma
term-group: PT
term-source: NCI

Axiom
annotated source: Central Neurocytoma
annotated property: has exact synonym
annotated target: Central Neurocytoma (WHO Grade II)
term-group: SY
term-source: NCI

Sex Cord-Stromal Tumor
type: Class
definition: A neoplasm arising in the ovary or testis. It is composed of granulosa cells, Leydig cells, Sertoli cells, and fibroblasts. Each of these cell types may constitute the only cellular component that is present in the neoplasm or it may be mixed with other cell types in various combinations. The prognosis can not always be predicted on histologic grounds alone. Approximately, 10% of these tumors may metastasize. Representative examples include granulosa cell tumor, Leydig cell tumor, Sertoli cell tumor, and tumors of the thecoma-fibroma group.
Has_NICHD_Parent: NCIT C3262
Concept_In_Subset: NCIT C132009
Concept_In_Subset: NCIT C90259
code: C3794
Semantic_Type: Neoplastic Process
Preferred_Name: Sex Cord-Stromal Tumor
UMLS_CUI: C0206724
Contributing_Source: NICHD
ALT_DEFINITION: A rare type of cancer that forms in the tissues that support the ovaries or testes. These tumors may release sex hormones. Sex cord-gonadal stromal tumors include granulosa cell, Sertoli cell, and Leydig cell tumors.
ALT_DEFINITION: A tumor arising in the ovary or testis. It is composed of one or more of the following: granulosa cells, Leydig cells, Sertoli cells, and/or fibroblasts.
ICD-O-3_Code: 8590/1
Neoplastic_Status: Undetermined
Legacy_Concept_Name: Sex_Cord-Stromal_Tumor
NICHD_Hierarchy_Term: Sex Cord-Stromal Tumor
has exact synonym: Sex Cord-Stromal Neoplasm
has exact synonym: Sex Cord-Stromal Tumor
has exact synonym: sex cord tumor
has exact synonym: sex cord-gonadal stromal tumor
has exact synonym: sex cord-stromal tumor
in subset: oncotree slim

Axiom
annotated source: Sex Cord-Stromal Tumor
annotated property: definition
annotated target: A neoplasm arising in the ovary or testis. It is composed of granulosa cells, Leydig cells, Sertoli cells, and fibroblasts. Each of these cell types may constitute the only cellular component that is present in the neoplasm or it may be mixed with other cell types in various combinations. The prognosis can not always be predicted on histologic grounds alone. Approximately, 10% of these tumors may metastasize. Representative examples include granulosa cell tumor, Leydig cell tumor, Sertoli cell tumor, and tumors of the thecoma-fibroma group.
def-source: NCI

Axiom
annotated source: Sex Cord-Stromal Tumor
annotated property: ALT_DEFINITION
annotated target: A rare type of cancer that forms in the tissues that support the ovaries or testes. These tumors may release sex hormones. Sex cord-gonadal stromal tumors include granulosa cell, Sertoli cell, and Leydig cell tumors.
def-source: NCI-GLOSS

Axiom
annotated source: Sex Cord-Stromal Tumor
annotated property: ALT_DEFINITION
annotated target: A tumor arising in the ovary or testis. It is composed of one or more of the following: granulosa cells, Leydig cells, Sertoli cells, and/or fibroblasts.
def-source: NICHD

Axiom
annotated source: Sex Cord-Stromal Tumor
annotated property: has exact synonym
annotated target: Sex Cord-Stromal Neoplasm
term-group: SY
term-source: NCI

Axiom
annotated source: Sex Cord-Stromal Tumor
annotated property: has exact synonym
annotated target: Sex Cord-Stromal Tumor
term-group: PT
term-source: NCI

Axiom
annotated source: Sex Cord-Stromal Tumor
annotated property: has exact synonym
annotated target: Sex Cord-Stromal Tumor
term-group: PT
term-source: NICHD

Axiom
annotated source: Sex Cord-Stromal Tumor
annotated property: has exact synonym
annotated target: sex cord tumor
term-group: PT
term-source: NCI-GLOSS
source-code: CDR0000642163

Axiom
annotated source: Sex Cord-Stromal Tumor
annotated property: has exact synonym
annotated target: sex cord-gonadal stromal tumor
term-group: PT
term-source: NCI-GLOSS
source-code: CDR0000642165

Axiom
annotated source: Sex Cord-Stromal Tumor
annotated property: has exact synonym
annotated target: sex cord-stromal tumor
term-group: PT
term-source: NCI-GLOSS
source-code: CDR0000642164

Subependymoma
type: Class
subclass of: Ependymal Tumor
definition: A benign, slow growing neoplasm which is typically attached to a ventricular wall. It is composed of glial tumor cell clusters embedded in an abundant fibrillary matrix with frequent microcystic change. Some lesions have the histological features of both subependymoma and ependymoma. It is often detected incidentally and has a very favorable prognosis. (Adapted from WHO.)
Concept_In_Subset: NCIT C126659
Concept_In_Subset: NCIT C61410
Concept_In_Subset: NCIT C77526
Concept_In_Subset: NCIT C88025
code: C3795
Semantic_Type: Neoplastic Process
Preferred_Name: Subependymoma
UMLS_CUI: C0206725
Contributing_Source: CDISC
ALT_DEFINITION: A benign neoplasm of the brain localized in the vicinity of a ventricular wall and is composed of glial tumor cell clusters embedded in an abundant fibrillary matrix with frequent microcystic changes.
ICD-O-3_Code: 9383/1
Neoplastic_Status: Undetermined
Legacy_Concept_Name: Subependymoma
has exact synonym: SUBEPENDYMOMA, BENIGN
has exact synonym: Subependymal Astrocytoma
has exact synonym: Subependymal Glioma
has exact synonym: Subependymoma
has exact synonym: WHO Grade I Ependymal Neoplasm
has exact synonym: WHO Grade I Ependymal Tumor
has exact synonym: Who Grade I Ependymal Neoplasm
has exact synonym: Who Grade I Ependymal Tumor
in subset: oncotree slim

Axiom
annotated source: Subependymoma
annotated property: definition
annotated target: A benign, slow growing neoplasm which is typically attached to a ventricular wall. It is composed of glial tumor cell clusters embedded in an abundant fibrillary matrix with frequent microcystic change. Some lesions have the histological features of both subependymoma and ependymoma. It is often detected incidentally and has a very favorable prognosis. (Adapted from WHO.)
def-source: NCI

Axiom
annotated source: Subependymoma
annotated property: ALT_DEFINITION
annotated target: A benign neoplasm of the brain localized in the vicinity of a ventricular wall and is composed of glial tumor cell clusters embedded in an abundant fibrillary matrix with frequent microcystic changes.
def-source: CDISC

Axiom
annotated source: Subependymoma
annotated property: has exact synonym
annotated target: SUBEPENDYMOMA, BENIGN
term-group: PT
term-source: CDISC

Axiom
annotated source: Subependymoma
annotated property: has exact synonym
annotated target: Subependymal Astrocytoma
term-group: SY
term-source: NCI

Axiom
annotated source: Subependymoma
annotated property: has exact synonym
annotated target: Subependymal Glioma
term-group: SY
term-source: CDISC

Axiom
annotated source: Subependymoma
annotated property: has exact synonym
annotated target: Subependymal Glioma
term-group: SY
term-source: NCI

Axiom
annotated source: Subependymoma
annotated property: has exact synonym
annotated target: Subependymoma
term-group: PT
term-source: NCI

Axiom
annotated source: Subependymoma
annotated property: has exact synonym
annotated target: Subependymoma
term-group: SY
term-source: NCI
source-code: TCGA
subsource-name: caDSR

Axiom
annotated source: Subependymoma
annotated property: has exact synonym
annotated target: WHO Grade I Ependymal Neoplasm
term-group: SY
term-source: NCI

Axiom
annotated source: Subependymoma
annotated property: has exact synonym
annotated target: WHO Grade I Ependymal Tumor
term-group: SY
term-source: NCI

Axiom
annotated source: Subependymoma
annotated property: has exact synonym
annotated target: Who Grade I Ependymal Neoplasm
term-group: SY
term-source: CDISC

Axiom
annotated source: Subependymoma
annotated property: has exact synonym
annotated target: Who Grade I Ependymal Tumor
term-group: SY
term-source: CDISC

Gliosarcoma
type: Class
definition: A rare histological variant of glioblastoma (WHO grade IV) characterized by a biphasic tissue pattern with alternating areas displaying glial and mesenchymal differentiation (WHO).
Concept_In_Subset: NCIT C126659
code: C3796
Semantic_Type: Neoplastic Process
Preferred_Name: Gliosarcoma
UMLS_CUI: C0206726
ALT_DEFINITION: A type of glioma (cancer of the brain that comes from glial, or supportive, cells).
ICD-O-3_Code: 9442/3
Neoplastic_Status: Malignant
Legacy_Concept_Name: Gliosarcoma
has exact synonym: Glioblastoma with a Sarcomatous Component
has exact synonym: Gliosarcoma
has exact synonym: gliosarcoma
in subset: oncotree slim

Axiom
annotated source: Gliosarcoma
annotated property: definition
annotated target: A rare histological variant of glioblastoma (WHO grade IV) characterized by a biphasic tissue pattern with alternating areas displaying glial and mesenchymal differentiation (WHO).
def-source: NCI

Axiom
annotated source: Gliosarcoma
annotated property: ALT_DEFINITION
annotated target: A type of glioma (cancer of the brain that comes from glial, or supportive, cells).
def-source: NCI-GLOSS

Axiom
annotated source: Gliosarcoma
annotated property: has exact synonym
annotated target: Glioblastoma with a Sarcomatous Component
term-group: SY
term-source: NCI

Axiom
annotated source: Gliosarcoma
annotated property: has exact synonym
annotated target: Gliosarcoma
term-group: PT
term-source: NCI

Axiom
annotated source: Gliosarcoma
annotated property: has exact synonym
annotated target: Gliosarcoma
term-group: SY
term-source: NCI
source-code: TCGA
subsource-name: caDSR

Axiom
annotated source: Gliosarcoma
annotated property: has exact synonym
annotated target: gliosarcoma
term-group: PT
term-source: NCI-GLOSS
source-code: CDR0000045701

Malignant Peripheral Nerve Sheath Tumor
type: Class
subclass of: Nerve Sheath Neoplasm
definition: An uncommon, highly aggressive malignant tumor, arising from the peripheral nerves and affecting mostly adults in their third to sixth decades of life. It usually occurs in medium-sized and large nerves of the buttock, thigh, upper arm, or the paraspinal region. It may be associated with neurofibromatosis 1 (NF1).
Concept_In_Subset: NCIT C102905
Concept_In_Subset: NCIT C103117
Concept_In_Subset: NCIT C126659
Concept_In_Subset: NCIT C61410
Concept_In_Subset: NCIT C77526
Concept_In_Subset: NCIT C88025
code: C3798
Semantic_Type: Neoplastic Process
Preferred_Name: Malignant Peripheral Nerve Sheath Tumor
UMLS_CUI: C0751690
Contributing_Source: CDISC
Contributing_Source: CTEP
ALT_DEFINITION: A malignant neoplasm, originating from the sheaths of the peripheral nerve.
ALT_DEFINITION: A type of soft tissue sarcoma that develops in cells that form a protective sheath (covering) around peripheral nerves, which are nerves that are outside of the central nervous system (brain and spinal cord).
ICD-O-3_Code: 9540/3
ICD-O-3_Code: 9560/3
Neoplastic_Status: Malignant
Legacy_Concept_Name: Malignant_Peripheral_Nerve_Sheath_Tumor
has exact synonym: MPNST
has exact synonym: Malig. periph. nerve sheath tum.
has exact synonym: Malignant Neoplasm of Peripheral Nerve Sheath
has exact synonym: Malignant Neoplasm of the Peripheral Nerve Sheath
has exact synonym: Malignant Neurilemmoma
has exact synonym: Malignant Neurilemoma
has exact synonym: Malignant Peripheral Nerve Sheath Neoplasm
has exact synonym: Malignant Peripheral Nerve Sheath Tumor
has exact synonym: Malignant Peripheral Nerve Sheath Tumour
has exact synonym: Malignant Schwannoma
has exact synonym: Malignant Tumor of Peripheral Nerve Sheath
has exact synonym: Malignant Tumor of the Peripheral Nerve Sheath
has exact synonym: Malignant peripheral nerve sheath tumor
has exact synonym: Neurofibrosarcoma
has exact synonym: Neurofibrosarcoma, Malignant
has exact synonym: Neurogenic Sarcoma
has exact synonym: SCHWANNOMA, MALIGNANT
has exact synonym: malignant peripheral nerve sheath tumor
in subset: oncotree slim

Axiom
annotated source: Malignant Peripheral Nerve Sheath Tumor
annotated property: definition
annotated target: An uncommon, highly aggressive malignant tumor, arising from the peripheral nerves and affecting mostly adults in their third to sixth decades of life. It usually occurs in medium-sized and large nerves of the buttock, thigh, upper arm, or the paraspinal region. It may be associated with neurofibromatosis 1 (NF1).
def-source: NCI

Axiom
annotated source: Malignant Peripheral Nerve Sheath Tumor
annotated property: ALT_DEFINITION
annotated target: A malignant neoplasm, originating from the sheaths of the peripheral nerve.
def-source: CDISC

Axiom
annotated source: Malignant Peripheral Nerve Sheath Tumor
annotated property: ALT_DEFINITION
annotated target: A type of soft tissue sarcoma that develops in cells that form a protective sheath (covering) around peripheral nerves, which are nerves that are outside of the central nervous system (brain and spinal cord).
def-source: NCI-GLOSS

Axiom
annotated source: Malignant Peripheral Nerve Sheath Tumor
annotated property: has exact synonym
annotated target: MPNST
term-group: AB
term-source: NCI

Axiom
annotated source: Malignant Peripheral Nerve Sheath Tumor
annotated property: has exact synonym
annotated target: MPNST
term-group: PT
term-source: NCI-GLOSS
source-code: CDR0000335498

Axiom
annotated source: Malignant Peripheral Nerve Sheath Tumor
annotated property: has exact synonym
annotated target: Malig. periph. nerve sheath tum.
term-group: SY
term-source: CTEP
source-code: 10026667
subsource-name: SDC

Axiom
annotated source: Malignant Peripheral Nerve Sheath Tumor
annotated property: has exact synonym
annotated target: Malignant Neoplasm of Peripheral Nerve Sheath
term-group: SY
term-source: NCI

Axiom
annotated source: Malignant Peripheral Nerve Sheath Tumor
annotated property: has exact synonym
annotated target: Malignant Neoplasm of the Peripheral Nerve Sheath
term-group: SY
term-source: NCI

Axiom
annotated source: Malignant Peripheral Nerve Sheath Tumor
annotated property: has exact synonym
annotated target: Malignant Neurilemmoma
term-group: SY
term-source: CDISC

Axiom
annotated source: Malignant Peripheral Nerve Sheath Tumor
annotated property: has exact synonym
annotated target: Malignant Neurilemmoma
term-group: SY
term-source: NCI

Axiom
annotated source: Malignant Peripheral Nerve Sheath Tumor
annotated property: has exact synonym
annotated target: Malignant Neurilemoma
term-group: SY
term-source: NCI

Axiom
annotated source: Malignant Peripheral Nerve Sheath Tumor
annotated property: has exact synonym
annotated target: Malignant Peripheral Nerve Sheath Neoplasm
term-group: SY
term-source: NCI

Axiom
annotated source: Malignant Peripheral Nerve Sheath Tumor
annotated property: has exact synonym
annotated target: Malignant Peripheral Nerve Sheath Tumor
term-group: PT
term-source: NCI

Axiom
annotated source: Malignant Peripheral Nerve Sheath Tumor
annotated property: has exact synonym
annotated target: Malignant Peripheral Nerve Sheath Tumor
term-group: SY
term-source: NCI
source-code: TCGA
subsource-name: caDSR

Axiom
annotated source: Malignant Peripheral Nerve Sheath Tumor
annotated property: has exact synonym
annotated target: Malignant Peripheral Nerve Sheath Tumour
term-group: SY
term-source: CDISC

Axiom
annotated source: Malignant Peripheral Nerve Sheath Tumor
annotated property: has exact synonym
annotated target: Malignant Peripheral Nerve Sheath Tumour
term-group: SY
term-source: NCI

Axiom
annotated source: Malignant Peripheral Nerve Sheath Tumor
annotated property: has exact synonym
annotated target: Malignant Schwannoma
term-group: SY
term-source: NCI

Axiom
annotated source: Malignant Peripheral Nerve Sheath Tumor
annotated property: has exact synonym
annotated target: Malignant Tumor of Peripheral Nerve Sheath
term-group: SY
term-source: NCI

Axiom
annotated source: Malignant Peripheral Nerve Sheath Tumor
annotated property: has exact synonym
annotated target: Malignant Tumor of the Peripheral Nerve Sheath
term-group: SY
term-source: NCI

Axiom
annotated source: Malignant Peripheral Nerve Sheath Tumor
annotated property: has exact synonym
annotated target: Malignant peripheral nerve sheath tumor
term-group: PT
term-source: CTEP
source-code: 10026667
subsource-name: SDC

Axiom
annotated source: Malignant Peripheral Nerve Sheath Tumor
annotated property: has exact synonym
annotated target: Neurofibrosarcoma
term-group: SY
term-source: NCI

Axiom
annotated source: Malignant Peripheral Nerve Sheath Tumor
annotated property: has exact synonym
annotated target: Neurofibrosarcoma, Malignant
term-group: SY
term-source: CDISC

Axiom
annotated source: Malignant Peripheral Nerve Sheath Tumor
annotated property: has exact synonym
annotated target: Neurogenic Sarcoma
term-group: SY
term-source: NCI

Axiom
annotated source: Malignant Peripheral Nerve Sheath Tumor
annotated property: has exact synonym
annotated target: SCHWANNOMA, MALIGNANT
term-group: PT
term-source: CDISC

Axiom
annotated source: Malignant Peripheral Nerve Sheath Tumor
annotated property: has exact synonym
annotated target: malignant peripheral nerve sheath tumor
term-group: PT
term-source: NCI-GLOSS
source-code: CDR0000335496

Epithelioid Hemangioendothelioma
type: Class
definition: A low-grade malignant blood vessel neoplasm. It is characterized by the presence of epithelioid endothelial cells. The neoplastic cells are arranged in cords and nests, which are embedded in a myxoid to hyalinized stroma.
Concept_In_Subset: NCIT C126659
code: C3800
Semantic_Type: Neoplastic Process
Preferred_Name: Epithelioid Hemangioendothelioma
UMLS_CUI: C0206732
ICD-O-3_Code: 9130/3
ICD-O-3_Code: 9133/1
ICD-O-3_Code: 9133/3
Neoplastic_Status: Malignant
Legacy_Concept_Name: Epithelioid_Hemangioendothelioma
has exact synonym: Epithelioid Angioendothelioma
has exact synonym: Epithelioid Angiosarcoma
has exact synonym: Epithelioid Hemangioendothelioma
in subset: oncotree slim

Axiom
annotated source: Epithelioid Hemangioendothelioma
annotated property: definition
annotated target: A low-grade malignant blood vessel neoplasm. It is characterized by the presence of epithelioid endothelial cells. The neoplastic cells are arranged in cords and nests, which are embedded in a myxoid to hyalinized stroma.
def-source: NCI

Axiom
annotated source: Epithelioid Hemangioendothelioma
annotated property: has exact synonym
annotated target: Epithelioid Angioendothelioma
term-group: SY
term-source: NCI

Axiom
annotated source: Epithelioid Hemangioendothelioma
annotated property: has exact synonym
annotated target: Epithelioid Angiosarcoma
term-group: SY
term-source: NCI

Axiom
annotated source: Epithelioid Hemangioendothelioma
annotated property: has exact synonym
annotated target: Epithelioid Hemangioendothelioma
term-group: PT
term-source: NCI

Hemangioblastoma
type: Class
subclass of: Neoplasm of Uncertain Histogenesis
definition: A WHO grade I tumor of uncertain histogenesis which is composed of stromal cells and abundant capillaries. Approximately 25% of hemangioblastomas are associated with Von Hippel-Lindau disease, a disease inherited through an autosomal dominant trait and characterized by the development of hemangioblastomas of the central nervous system and retina, clear cell renal carcinoma, pheochromocytoma, and pancreatic and inner ear tumors. (Adapted from WHO)
Concept_In_Subset: NCIT C126659
code: C3801
Semantic_Type: Neoplastic Process
Preferred_Name: Hemangioblastoma
UMLS_CUI: C0206734
ICD-O-3_Code: 9161/1
Neoplastic_Status: Undetermined
Legacy_Concept_Name: Hemangioblastoma
has exact synonym: Angioblastoma
has exact synonym: Capillary Hemangioblastoma
has exact synonym: Hemangioblastoma
in subset: oncotree slim

Axiom
annotated source: Hemangioblastoma
annotated property: definition
annotated target: A WHO grade I tumor of uncertain histogenesis which is composed of stromal cells and abundant capillaries. Approximately 25% of hemangioblastomas are associated with Von Hippel-Lindau disease, a disease inherited through an autosomal dominant trait and characterized by the development of hemangioblastomas of the central nervous system and retina, clear cell renal carcinoma, pheochromocytoma, and pancreatic and inner ear tumors. (Adapted from WHO)
def-source: NCI

Axiom
annotated source: Hemangioblastoma
annotated property: has exact synonym
annotated target: Angioblastoma
term-group: SY
term-source: NCI

Axiom
annotated source: Hemangioblastoma
annotated property: has exact synonym
annotated target: Capillary Hemangioblastoma
term-group: SY
term-source: NCI

Axiom
annotated source: Hemangioblastoma
annotated property: has exact synonym
annotated target: Hemangioblastoma
term-group: PT
term-source: NCI

Axiom
annotated source: Hemangioblastoma
annotated property: has exact synonym
annotated target: Hemangioblastoma
term-group: SY
term-source: NCI
source-code: TCGA
subsource-name: caDSR

Rhabdoid Tumor
type: Class
subclass of: Embryonal Neoplasm
definition: An aggressive malignant embryonal neoplasm usually occurring during childhood. It is characterized by the presence of large cells with abundant cytoplasm, large eccentric nucleus, and a prominent nucleolus and it is associated with abnormalities of chromosome 22. It can arise from the central nervous system, kidney, and the soft tissues. The prognosis is poor.
Has_NICHD_Parent: NCIT C9305
Concept_In_Subset: NCIT C126659
Concept_In_Subset: NCIT C132009
Concept_In_Subset: NCIT C90259
code: C3808
Semantic_Type: Neoplastic Process
Preferred_Name: Rhabdoid Tumor
UMLS_CUI: C0206743
Contributing_Source: NICHD
ALT_DEFINITION: A malignant tumor of either the central nervous system (CNS) or the kidney. Malignant rhabdoid tumors of the CNS often have an abnormality of chromosome 22. These tumors usually occur in children younger than 2 years.
ALT_DEFINITION: Extremely aggressive malignancies that generally occur in infants and young children. The most common locations are the kidney and central nervous system (CNS), although they can also arise in most soft tissue sites. Approximately two-thirds of patients will present with advanced-stage disease. Rhabdoid tumors of the kidney tend to metastasize to the CNS and lungs. Rhabdoid tumors are associated with mutations of SMARCB1 (INI-1), a tumor suppressor gene.
ICD-O-3_Code: 8963/3
Neoplastic_Status: Malignant
Legacy_Concept_Name: Rhabdoid_Tumor
NICHD_Hierarchy_Term: Rhabdoid Tumor
has exact synonym: Rhabdoid Sarcoma
has exact synonym: Rhabdoid Tumor
has exact synonym: rhabdoid tumor
in subset: oncotree slim

Axiom
annotated source: Rhabdoid Tumor
annotated property: definition
annotated target: An aggressive malignant embryonal neoplasm usually occurring during childhood. It is characterized by the presence of large cells with abundant cytoplasm, large eccentric nucleus, and a prominent nucleolus and it is associated with abnormalities of chromosome 22. It can arise from the central nervous system, kidney, and the soft tissues. The prognosis is poor.
def-source: NCI

Axiom
annotated source: Rhabdoid Tumor
annotated property: ALT_DEFINITION
annotated target: A malignant tumor of either the central nervous system (CNS) or the kidney. Malignant rhabdoid tumors of the CNS often have an abnormality of chromosome 22. These tumors usually occur in children younger than 2 years.
def-source: NCI-GLOSS

Axiom
annotated source: Rhabdoid Tumor
annotated property: ALT_DEFINITION
annotated target: Extremely aggressive malignancies that generally occur in infants and young children. The most common locations are the kidney and central nervous system (CNS), although they can also arise in most soft tissue sites. Approximately two-thirds of patients will present with advanced-stage disease. Rhabdoid tumors of the kidney tend to metastasize to the CNS and lungs. Rhabdoid tumors are associated with mutations of SMARCB1 (INI-1), a tumor suppressor gene.
def-source: NICHD

Axiom
annotated source: Rhabdoid Tumor
annotated property: has exact synonym
annotated target: Rhabdoid Sarcoma
term-group: AQS
term-source: NCI

Axiom
annotated source: Rhabdoid Tumor
annotated property: has exact synonym
annotated target: Rhabdoid Tumor
term-group: PT
term-source: NCI

Axiom
annotated source: Rhabdoid Tumor
annotated property: has exact synonym
annotated target: Rhabdoid Tumor
term-group: PT
term-source: NICHD

Axiom
annotated source: Rhabdoid Tumor
annotated property: has exact synonym
annotated target: rhabdoid tumor
term-group: PT
term-source: NCI-GLOSS
source-code: CDR0000046139

Carcinoma of Unknown Primary Origin
type: Class
definition: A carcinoma which has metastasized from an unknown primary anatomic site.
Concept_In_Subset: NCIT C116977
code: C3812
Semantic_Type: Neoplastic Process
Display_Name: Carcinoma of Unknown Primary Origin
Preferred_Name: Carcinoma of Unknown Primary Origin
UMLS_CUI: C0220647
Contributing_Source: CTRP
ALT_DEFINITION: A case in which cancer cells are found in the body, but the place where the cells first started growing (the origin or primary site) cannot be determined.
Neoplastic_Status: Malignant
Legacy_Concept_Name: Carcinoma_of_Unknown_Primary
has exact synonym: CUP
has exact synonym: Carcinoma of Unknown Primary
has exact synonym: Carcinoma of Unknown Primary Origin
has exact synonym: carcinoma of unknown primary
in subset: oncotree slim

Axiom
annotated source: Carcinoma of Unknown Primary Origin
annotated property: definition
annotated target: A carcinoma which has metastasized from an unknown primary anatomic site.
def-source: NCI

Axiom
annotated source: Carcinoma of Unknown Primary Origin
annotated property: ALT_DEFINITION
annotated target: A case in which cancer cells are found in the body, but the place where the cells first started growing (the origin or primary site) cannot be determined.
def-source: NCI-GLOSS

Axiom
annotated source: Carcinoma of Unknown Primary Origin
annotated property: has exact synonym
annotated target: CUP
term-group: PT
term-source: NCI-GLOSS
source-code: CDR0000527198

Axiom
annotated source: Carcinoma of Unknown Primary Origin
annotated property: has exact synonym
annotated target: Carcinoma of Unknown Primary
term-group: SY
term-source: NCI

Axiom
annotated source: Carcinoma of Unknown Primary Origin
annotated property: has exact synonym
annotated target: Carcinoma of Unknown Primary Origin
term-group: PT
term-source: NCI

Axiom
annotated source: Carcinoma of Unknown Primary Origin
annotated property: has exact synonym
annotated target: carcinoma of unknown primary
term-group: PT
term-source: NCI-GLOSS
source-code: CDR0000527198

PEComa
type: Class
definition: A soft tissue mesenchymal tumor with perivascular epithelioid cell differentiation. Representative examples include angiomyolipoma, clear cell-sugar-tumor of the lung, and lymphangioleiomyomatosis.
code: C38150
Semantic_Type: Neoplastic Process
Preferred_Name: PEComa
UMLS_CUI: C1300127
Neoplastic_Status: Undetermined
Legacy_Concept_Name: Neoplasm_with_Perivascular_Epithelioid_Cell_Differentiation
has exact synonym: Neoplasm with Perivascular Epithelioid Cell Differentiation
has exact synonym: PEComa
has exact synonym: Tumor with Perivascular Epithelioid Cell Differentiation
in subset: oncotree slim

Axiom
annotated source: PEComa
annotated property: definition
annotated target: A soft tissue mesenchymal tumor with perivascular epithelioid cell differentiation. Representative examples include angiomyolipoma, clear cell-sugar-tumor of the lung, and lymphangioleiomyomatosis.
def-source: NCI

Axiom
annotated source: PEComa
annotated property: has exact synonym
annotated target: Neoplasm with Perivascular Epithelioid Cell Differentiation
term-group: SY
term-source: NCI

Axiom
annotated source: PEComa
annotated property: has exact synonym
annotated target: PEComa
term-group: PT
term-source: NCI

Axiom
annotated source: PEComa
annotated property: has exact synonym
annotated target: Tumor with Perivascular Epithelioid Cell Differentiation
term-group: SY
term-source: NCI

Combined Hepatocellular Carcinoma and Cholangiocarcinoma
type: Class
definition: A rare tumor containing unequivocal elements of both hepatocellular and cholangiocarcinoma that are intimately admixed. This tumor should be distinguished from separate hepatocellular carcinoma and cholangiocarcinoma arising in the same liver. The prognosis of this tumor is poor.
Concept_In_Subset: NCIT C116977
Concept_In_Subset: NCIT C126659
code: C3828
Semantic_Type: Neoplastic Process
Display_Name: Combined Hepatocellular Cancer and Cholangiocarcinoma
Preferred_Name: Combined Hepatocellular Carcinoma and Cholangiocarcinoma
UMLS_CUI: C0221287
Contributing_Source: CTRP
ICD-O-3_Code: 8180/3
Neoplastic_Status: Malignant
Legacy_Concept_Name: Combined_Hepatocellular_Carcinoma_and_Cholangiocarcinoma
has exact synonym: Carcinoma of Liver and Intrahepatic Biliary Tract
has exact synonym: Carcinoma of the Liver and Intrahepatic Biliary Tract
has exact synonym: Cholangiohepatoma
has exact synonym: Combined Hepatocellular Cancer and Cholangiocarcinoma (Bile Duct Cancer)
has exact synonym: Combined Hepatocellular Carcinoma and Cholangiocarcinoma
has exact synonym: Hepatocholangiocarcinoma
has exact synonym: Liver and Intrahepatic Biliary Tract Carcinoma
has exact synonym: Mixed Hepatocellular Cholangiocarcinoma
in subset: oncotree slim

Axiom
annotated source: Combined Hepatocellular Carcinoma and Cholangiocarcinoma
annotated property: definition
annotated target: A rare tumor containing unequivocal elements of both hepatocellular and cholangiocarcinoma that are intimately admixed. This tumor should be distinguished from separate hepatocellular carcinoma and cholangiocarcinoma arising in the same liver. The prognosis of this tumor is poor.
def-source: NCI

Axiom
annotated source: Combined Hepatocellular Carcinoma and Cholangiocarcinoma
annotated property: has exact synonym
annotated target: Carcinoma of Liver and Intrahepatic Biliary Tract
term-group: SY
term-source: NCI

Axiom
annotated source: Combined Hepatocellular Carcinoma and Cholangiocarcinoma
annotated property: has exact synonym
annotated target: Carcinoma of the Liver and Intrahepatic Biliary Tract
term-group: SY
term-source: NCI

Axiom
annotated source: Combined Hepatocellular Carcinoma and Cholangiocarcinoma
annotated property: has exact synonym
annotated target: Cholangiohepatoma
term-group: SY
term-source: NCI

Axiom
annotated source: Combined Hepatocellular Carcinoma and Cholangiocarcinoma
annotated property: has exact synonym
annotated target: Combined Hepatocellular Cancer and Cholangiocarcinoma (Bile Duct Cancer)
term-group: DN
term-source: CTRP

Axiom
annotated source: Combined Hepatocellular Carcinoma and Cholangiocarcinoma
annotated property: has exact synonym
annotated target: Combined Hepatocellular Carcinoma and Cholangiocarcinoma
term-group: PT
term-source: NCI

Axiom
annotated source: Combined Hepatocellular Carcinoma and Cholangiocarcinoma
annotated property: has exact synonym
annotated target: Hepatocholangiocarcinoma
term-group: SY
term-source: NCI

Axiom
annotated source: Combined Hepatocellular Carcinoma and Cholangiocarcinoma
annotated property: has exact synonym
annotated target: Liver and Intrahepatic Biliary Tract Carcinoma
term-group: SY
term-source: NCI

Axiom
annotated source: Combined Hepatocellular Carcinoma and Cholangiocarcinoma
annotated property: has exact synonym
annotated target: Mixed Hepatocellular Cholangiocarcinoma
term-group: SY
term-source: NCI

Pancreatic Intraductal Papillary-Mucinous Neoplasm
type: Class
definition: A usually slow-growing epithelial neoplasm with ductal differentiation that arises from the exocrine pancreas and grows mostly within the pancreatic ducts. Grossly, it is characterized by the presence of intraductal masses. Morphologically, there is proliferation of mucin-producing cells within the pancreatic ducts, intraductal accumulation of mucin, and a papillary growth pattern. It may be associated with the presence of an invasive carcinoma. It usually occurs in older patients. Signs and symptoms include epigastric pain, weight loss, jaundice, chronic pancreatitis, and diabetes mellitus.
Concept_In_Subset: NCIT C116977
code: C38342
Semantic_Type: Neoplastic Process
Display_Name: Pancreatic Intraductal Papillary-Mucinous Neoplasm
Preferred_Name: Pancreatic Intraductal Papillary-Mucinous Neoplasm
UMLS_CUI: C1518869
Contributing_Source: CTRP
Neoplastic_Status: Undetermined
Legacy_Concept_Name: Pancreatic_Intraductal_Papillary-Mucinous_Neoplasm
has exact synonym: IPMN
has exact synonym: Pancreatic IPMN
has exact synonym: Pancreatic Intraductal Papillary-Mucinous Neoplasm
has exact synonym: Pancreatic Intraductal Papillary-Mucinous Tumor
in subset: oncotree slim

Axiom
annotated source: Pancreatic Intraductal Papillary-Mucinous Neoplasm
annotated property: definition
annotated target: A usually slow-growing epithelial neoplasm with ductal differentiation that arises from the exocrine pancreas and grows mostly within the pancreatic ducts. Grossly, it is characterized by the presence of intraductal masses. Morphologically, there is proliferation of mucin-producing cells within the pancreatic ducts, intraductal accumulation of mucin, and a papillary growth pattern. It may be associated with the presence of an invasive carcinoma. It usually occurs in older patients. Signs and symptoms include epigastric pain, weight loss, jaundice, chronic pancreatitis, and diabetes mellitus.
def-source: NCI

Axiom
annotated source: Pancreatic Intraductal Papillary-Mucinous Neoplasm
annotated property: has exact synonym
annotated target: IPMN
term-group: AB
term-source: NCI

Axiom
annotated source: Pancreatic Intraductal Papillary-Mucinous Neoplasm
annotated property: has exact synonym
annotated target: Pancreatic IPMN
term-group: SY
term-source: NCI

Axiom
annotated source: Pancreatic Intraductal Papillary-Mucinous Neoplasm
annotated property: has exact synonym
annotated target: Pancreatic Intraductal Papillary-Mucinous Neoplasm
term-group: PT
term-source: NCI

Axiom
annotated source: Pancreatic Intraductal Papillary-Mucinous Neoplasm
annotated property: has exact synonym
annotated target: Pancreatic Intraductal Papillary-Mucinous Tumor
term-group: SY
term-source: NCI

Gallbladder Carcinoma
type: Class
definition: A malignant tumor arising from the epithelium of the gallbladder. It is usually associated with the presence of gallstones. Clinical symptoms are not specific and usually present late in the course. Morphologically, most gallbladder carcinomas are adenocarcinomas; squamous cell carcinomas, adenosquamous carcinomas, signet ring carcinomas, and undifferentiated carcinomas can also occur.
Concept_In_Subset: NCIT C102905
Concept_In_Subset: NCIT C103066
Concept_In_Subset: NCIT C116977
Concept_In_Subset: NCIT C126659
code: C3844
Semantic_Type: Neoplastic Process
Display_Name: Gallbladder Cancer
Preferred_Name: Gallbladder Carcinoma
UMLS_CUI: C0235782
Contributing_Source: CTEP
Contributing_Source: CTRP
ALT_DEFINITION: Cancer that forms in tissues of the gallbladder. The gallbladder is a pear-shaped organ below the liver that collects and stores bile (a fluid made by the liver to digest fat). Gallbladder cancer begins in the innermost layer of tissue and spreads through the outer layers as it grows.
Neoplastic_Status: Malignant
Legacy_Concept_Name: Gallbladder_Carcinoma
has exact synonym: Cancer of Gallbladder
has exact synonym: Cancer of the Gallbladder
has exact synonym: Carcinoma of Gallbladder
has exact synonym: Carcinoma of the Gallbladder
has exact synonym: Gall bladder carcinoma (adeno)
has exact synonym: Gall bladder carcinoma (adenocarcinoma)
has exact synonym: Gallbladder Cancer
has exact synonym: Gallbladder Carcinoma
has exact synonym: gallbladder cancer
in subset: oncotree slim

Axiom
annotated source: Gallbladder Carcinoma
annotated property: definition
annotated target: A malignant tumor arising from the epithelium of the gallbladder. It is usually associated with the presence of gallstones. Clinical symptoms are not specific and usually present late in the course. Morphologically, most gallbladder carcinomas are adenocarcinomas; squamous cell carcinomas, adenosquamous carcinomas, signet ring carcinomas, and undifferentiated carcinomas can also occur.
def-source: NCI

Axiom
annotated source: Gallbladder Carcinoma
annotated property: ALT_DEFINITION
annotated target: Cancer that forms in tissues of the gallbladder. The gallbladder is a pear-shaped organ below the liver that collects and stores bile (a fluid made by the liver to digest fat). Gallbladder cancer begins in the innermost layer of tissue and spreads through the outer layers as it grows.
def-source: NCI-GLOSS

Axiom
annotated source: Gallbladder Carcinoma
annotated property: has exact synonym
annotated target: Cancer of Gallbladder
term-group: SY
term-source: NCI

Axiom
annotated source: Gallbladder Carcinoma
annotated property: has exact synonym
annotated target: Cancer of the Gallbladder
term-group: SY
term-source: NCI

Axiom
annotated source: Gallbladder Carcinoma
annotated property: has exact synonym
annotated target: Carcinoma of Gallbladder
term-group: SY
term-source: NCI

Axiom
annotated source: Gallbladder Carcinoma
annotated property: has exact synonym
annotated target: Carcinoma of the Gallbladder
term-group: SY
term-source: NCI

Axiom
annotated source: Gallbladder Carcinoma
annotated property: has exact synonym
annotated target: Gall bladder carcinoma (adeno)
term-group: SY
term-source: CTEP
source-code: 10017618
subsource-name: SDC

Axiom
annotated source: Gallbladder Carcinoma
annotated property: has exact synonym
annotated target: Gall bladder carcinoma (adenocarcinoma)
term-group: PT
term-source: CTEP
source-code: 10017618
subsource-name: SDC

Axiom
annotated source: Gallbladder Carcinoma
annotated property: has exact synonym
annotated target: Gallbladder Cancer
term-group: DN
term-source: CTRP

Axiom
annotated source: Gallbladder Carcinoma
annotated property: has exact synonym
annotated target: Gallbladder Cancer
term-group: PT
term-source: CTRP

Axiom
annotated source: Gallbladder Carcinoma
annotated property: has exact synonym
annotated target: Gallbladder Cancer
term-group: SY
term-source: NCI

Axiom
annotated source: Gallbladder Carcinoma
annotated property: has exact synonym
annotated target: Gallbladder Carcinoma
term-group: PT
term-source: NCI

Axiom
annotated source: Gallbladder Carcinoma
annotated property: has exact synonym
annotated target: Gallbladder Carcinoma
term-group: SY
term-source: CTRP

Axiom
annotated source: Gallbladder Carcinoma
annotated property: has exact synonym
annotated target: gallbladder cancer
term-group: PT
term-source: NCI-GLOSS
source-code: CDR0000446566

Gastrointestinal Stromal Tumor
type: Class
definition: A stromal tumor most commonly seen in the gastrointestinal tract. Rare cases of solitary masses in the omentum or the mesentery have also been reported (extragastrointestinal gastrointestinal stromal tumor). It is a tumor that differentiates along the lines of interstitial cells of Cajal. Most cases contain KIT- or PDGFRA-activating mutations. Until recently, surgery has been the only effective therapy for this tumor. However, many patients still experience recurrence. Conventional chemotherapy and radiation therapy have been of limited value. A KIT tyrosine kinase inhibitor, imatinib mesylate (also known as STI-571 or Gleevec), is now effective in the treatment of relapsed and unresectable cases.
Concept_In_Subset: NCIT C102905
Concept_In_Subset: NCIT C103117
Concept_In_Subset: NCIT C116977
Concept_In_Subset: NCIT C126659
code: C3868
Semantic_Type: Neoplastic Process
Display_Name: Gastrointestinal Stromal Tumor
Preferred_Name: Gastrointestinal Stromal Tumor
UMLS_CUI: C0238198
Contributing_Source: CTEP
Contributing_Source: CTRP
ALT_DEFINITION: A type of tumor that usually begins in cells in the wall of the gastrointestinal tract. It can be benign or malignant.
ICD-O-3_Code: 8936/1
Neoplastic_Status: Undetermined
Legacy_Concept_Name: Gastrointestinal_Stromal_Tumor
has exact synonym: GIST
has exact synonym: Gastrointestinal Stromal Neoplasm
has exact synonym: Gastrointestinal Stromal Tumor
has exact synonym: Gastrointestinal Stromal Tumor (GIST)
has exact synonym: Gastrointestinal stromal tumor
has exact synonym: gastrointestinal stromal tumor
in subset: oncotree slim

Axiom
annotated source: Gastrointestinal Stromal Tumor
annotated property: definition
annotated target: A stromal tumor most commonly seen in the gastrointestinal tract. Rare cases of solitary masses in the omentum or the mesentery have also been reported (extragastrointestinal gastrointestinal stromal tumor). It is a tumor that differentiates along the lines of interstitial cells of Cajal. Most cases contain KIT- or PDGFRA-activating mutations. Until recently, surgery has been the only effective therapy for this tumor. However, many patients still experience recurrence. Conventional chemotherapy and radiation therapy have been of limited value. A KIT tyrosine kinase inhibitor, imatinib mesylate (also known as STI-571 or Gleevec), is now effective in the treatment of relapsed and unresectable cases.
def-source: NCI

Axiom
annotated source: Gastrointestinal Stromal Tumor
annotated property: ALT_DEFINITION
annotated target: A type of tumor that usually begins in cells in the wall of the gastrointestinal tract. It can be benign or malignant.
def-source: NCI-GLOSS

Axiom
annotated source: Gastrointestinal Stromal Tumor
annotated property: has exact synonym
annotated target: GIST
term-group: AB
term-source: NCI

Axiom
annotated source: Gastrointestinal Stromal Tumor
annotated property: has exact synonym
annotated target: GIST
term-group: PT
term-source: NCI-GLOSS
source-code: CDR0000044406

Axiom
annotated source: Gastrointestinal Stromal Tumor
annotated property: has exact synonym
annotated target: Gastrointestinal Stromal Neoplasm
term-group: SY
term-source: NCI

Axiom
annotated source: Gastrointestinal Stromal Tumor
annotated property: has exact synonym
annotated target: Gastrointestinal Stromal Tumor
term-group: PT
term-source: NCI

Axiom
annotated source: Gastrointestinal Stromal Tumor
annotated property: has exact synonym
annotated target: Gastrointestinal Stromal Tumor (GIST)
term-group: DN
term-source: CTRP

Axiom
annotated source: Gastrointestinal Stromal Tumor
annotated property: has exact synonym
annotated target: Gastrointestinal stromal tumor
term-group: PT
term-source: CTEP
source-code: 10051066
subsource-name: SDC

Axiom
annotated source: Gastrointestinal Stromal Tumor
annotated property: has exact synonym
annotated target: gastrointestinal stromal tumor
term-group: PT
term-source: NCI-GLOSS
source-code: CDR0000044998

Nasopharyngeal Carcinoma
type: Class
definition: A carcinoma arising from the nasopharyngeal epithelium. It includes the following types: keratinizing squamous cell carcinoma, nonkeratinizing carcinoma (differentiated and undifferentiated), basaloid squamous cell carcinoma, and papillary adenocarcinoma.
Concept_In_Subset: NCIT C102905
Concept_In_Subset: NCIT C103076
Concept_In_Subset: NCIT C116977
code: C3871
Semantic_Type: Neoplastic Process
Display_Name: Nasopharyngeal Cancer
Preferred_Name: Nasopharyngeal Carcinoma
UMLS_CUI: C2931822
Contributing_Source: CTEP
Contributing_Source: CTRP
ALT_DEFINITION: Cancer that forms in tissues of the nasopharynx (upper part of the throat behind the nose). Most nasopharyngeal cancers are squamous cell carcinomas (cancer that begins in flat cells lining the nasopharynx).
Neoplastic_Status: Malignant
Legacy_Concept_Name: Nasopharyngeal_Carcinoma
has exact synonym: Cancer of Nasopharynx
has exact synonym: Cancer of the Nasopharynx
has exact synonym: Carcinoma of Nasopharynx
has exact synonym: Carcinoma of the Nasopharynx
has exact synonym: NPC
has exact synonym: Nasopharyngeal Cancer
has exact synonym: Nasopharyngeal Carcinoma
has exact synonym: Nasopharyngeal Throat Cancer
has exact synonym: Nasopharyngeal carcinoma
has exact synonym: nasopharyngeal cancer
in subset: oncotree slim

Axiom
annotated source: Nasopharyngeal Carcinoma
annotated property: definition
annotated target: A carcinoma arising from the nasopharyngeal epithelium. It includes the following types: keratinizing squamous cell carcinoma, nonkeratinizing carcinoma (differentiated and undifferentiated), basaloid squamous cell carcinoma, and papillary adenocarcinoma.
def-source: NCI

Axiom
annotated source: Nasopharyngeal Carcinoma
annotated property: ALT_DEFINITION
annotated target: Cancer that forms in tissues of the nasopharynx (upper part of the throat behind the nose). Most nasopharyngeal cancers are squamous cell carcinomas (cancer that begins in flat cells lining the nasopharynx).
def-source: NCI-GLOSS

Axiom
annotated source: Nasopharyngeal Carcinoma
annotated property: has exact synonym
annotated target: Cancer of Nasopharynx
term-group: SY
term-source: NCI

Axiom
annotated source: Nasopharyngeal Carcinoma
annotated property: has exact synonym
annotated target: Cancer of the Nasopharynx
term-group: SY
term-source: NCI

Axiom
annotated source: Nasopharyngeal Carcinoma
annotated property: has exact synonym
annotated target: Carcinoma of Nasopharynx
term-group: SY
term-source: NCI

Axiom
annotated source: Nasopharyngeal Carcinoma
annotated property: has exact synonym
annotated target: Carcinoma of the Nasopharynx
term-group: SY
term-source: NCI

Axiom
annotated source: Nasopharyngeal Carcinoma
annotated property: has exact synonym
annotated target: NPC
term-group: AB
term-source: NCI

Axiom
annotated source: Nasopharyngeal Carcinoma
annotated property: has exact synonym
annotated target: Nasopharyngeal Cancer
term-group: SY
term-source: NCI

Axiom
annotated source: Nasopharyngeal Carcinoma
annotated property: has exact synonym
annotated target: Nasopharyngeal Carcinoma
term-group: PT
term-source: NCI

Axiom
annotated source: Nasopharyngeal Carcinoma
annotated property: has exact synonym
annotated target: Nasopharyngeal Throat Cancer
term-group: DN
term-source: CTRP

Axiom
annotated source: Nasopharyngeal Carcinoma
annotated property: has exact synonym
annotated target: Nasopharyngeal carcinoma
term-group: PT
term-source: CTEP
source-code: 10028786
subsource-name: SDC

Axiom
annotated source: Nasopharyngeal Carcinoma
annotated property: has exact synonym
annotated target: nasopharyngeal cancer
term-group: PT
term-source: NCI-GLOSS
source-code: CDR0000445072

Ovarian Germ Cell Tumor
type: Class
definition: A neoplasm that arises from the ovary and originates from germ cells. Representative examples include teratoma, embryonal carcinoma, yolk sac tumor, and dysgerminoma.
Has_NICHD_Parent: NCIT C114801
Concept_In_Subset: NCIT C116977
Concept_In_Subset: NCIT C118464
Concept_In_Subset: NCIT C126659
Concept_In_Subset: NCIT C90259
code: C3873
Semantic_Type: Neoplastic Process
Display_Name: Ovarian Germ Cell Tumor
Preferred_Name: Ovarian Germ Cell Tumor
UMLS_CUI: C0238324
Contributing_Source: CTRP
Contributing_Source: MedDRA
Contributing_Source: NICHD
ALT_DEFINITION: A neoplasm arising from gonadal tissue within the ovary.
ALT_DEFINITION: An abnormal mass of tissue that forms in germ (egg) cells in the ovary (female reproductive gland in which the eggs are formed). These tumors usually occur in teenage girls or young women, usually affect just one ovary, and can be benign (not cancer) or malignant (cancer). The most common ovarian germ cell tumor is called dysgerminoma.
Neoplastic_Status: Undetermined
Legacy_Concept_Name: Ovarian_Germ_Cell_Tumor
NICHD_Hierarchy_Term: Ovarian Germ Cell Tumor
has exact synonym: Germ Cell Neoplasm of Ovary
has exact synonym: Germ Cell Neoplasm of the Ovary
has exact synonym: Germ Cell Tumor of Ovary
has exact synonym: Germ Cell Tumor of the Ovary
has exact synonym: Ovarian Germ Cell Neoplasm
has exact synonym: Ovarian Germ Cell Tumor
has exact synonym: ovarian germ cell tumor
in subset: oncotree slim

Axiom
annotated source: Ovarian Germ Cell Tumor
annotated property: definition
annotated target: A neoplasm that arises from the ovary and originates from germ cells. Representative examples include teratoma, embryonal carcinoma, yolk sac tumor, and dysgerminoma.
def-source: NCI

Axiom
annotated source: Ovarian Germ Cell Tumor
annotated property: ALT_DEFINITION
annotated target: A neoplasm arising from gonadal tissue within the ovary.
def-source: NICHD

Axiom
annotated source: Ovarian Germ Cell Tumor
annotated property: ALT_DEFINITION
annotated target: An abnormal mass of tissue that forms in germ (egg) cells in the ovary (female reproductive gland in which the eggs are formed). These tumors usually occur in teenage girls or young women, usually affect just one ovary, and can be benign (not cancer) or malignant (cancer). The most common ovarian germ cell tumor is called dysgerminoma.
def-source: NCI-GLOSS

Axiom
annotated source: Ovarian Germ Cell Tumor
annotated property: has exact synonym
annotated target: Germ Cell Neoplasm of Ovary
term-group: SY
term-source: NCI

Axiom
annotated source: Ovarian Germ Cell Tumor
annotated property: has exact synonym
annotated target: Germ Cell Neoplasm of the Ovary
term-group: SY
term-source: NCI

Axiom
annotated source: Ovarian Germ Cell Tumor
annotated property: has exact synonym
annotated target: Germ Cell Tumor of Ovary
term-group: SY
term-source: NCI

Axiom
annotated source: Ovarian Germ Cell Tumor
annotated property: has exact synonym
annotated target: Germ Cell Tumor of the Ovary
term-group: SY
term-source: NCI

Axiom
annotated source: Ovarian Germ Cell Tumor
annotated property: has exact synonym
annotated target: Ovarian Germ Cell Neoplasm
term-group: SY
term-source: NCI

Axiom
annotated source: Ovarian Germ Cell Tumor
annotated property: has exact synonym
annotated target: Ovarian Germ Cell Tumor
term-group: DN
term-source: CTRP

Axiom
annotated source: Ovarian Germ Cell Tumor
annotated property: has exact synonym
annotated target: Ovarian Germ Cell Tumor
term-group: PT
term-source: NCI

Axiom
annotated source: Ovarian Germ Cell Tumor
annotated property: has exact synonym
annotated target: Ovarian Germ Cell Tumor
term-group: PT
term-source: NICHD

Axiom
annotated source: Ovarian Germ Cell Tumor
annotated property: has exact synonym
annotated target: ovarian germ cell tumor
term-group: PT
term-source: NCI-GLOSS
source-code: CDR0000446560

Testicular Teratoma
type: Class
subclass of: NCIT C9313
definition: A non-seminomatous germ cell tumor arising from the testis. It is characterized by the presence of various tissues which correspond to the different germinal layers (endoderm, mesoderm, and ectoderm). According to the level of differentiation of the tissues which comprise the tumor, testicular teratomas are classified as mature or immature. Mature teratomas are composed of well differentiated, adult-type tissues. Immature teratomas are composed of immature, fetal type-tissues. Testicular teratomas in children follow a benign clinical course whereas in postpubertal patients may metastasize to other anatomic sites.
Concept_In_Subset: NCIT C116977
code: C3877
Semantic_Type: Neoplastic Process
Display_Name: Testicular Teratoma
Preferred_Name: Testicular Teratoma
UMLS_CUI: C0238451
Contributing_Source: CTRP
Neoplastic_Status: Undetermined
Legacy_Concept_Name: Testicular_Teratoma
has exact synonym: Teratoma of Testis
has exact synonym: Teratoma of the Testis
has exact synonym: Testicular Teratoma
in subset: oncotree slim

Axiom
annotated source: Testicular Teratoma
annotated property: definition
annotated target: A non-seminomatous germ cell tumor arising from the testis. It is characterized by the presence of various tissues which correspond to the different germinal layers (endoderm, mesoderm, and ectoderm). According to the level of differentiation of the tissues which comprise the tumor, testicular teratomas are classified as mature or immature. Mature teratomas are composed of well differentiated, adult-type tissues. Immature teratomas are composed of immature, fetal type-tissues. Testicular teratomas in children follow a benign clinical course whereas in postpubertal patients may metastasize to other anatomic sites.
def-source: NCI

Axiom
annotated source: Testicular Teratoma
annotated property: has exact synonym
annotated target: Teratoma of Testis
term-group: SY
term-source: NCI

Axiom
annotated source: Testicular Teratoma
annotated property: has exact synonym
annotated target: Teratoma of the Testis
term-group: SY
term-source: NCI

Axiom
annotated source: Testicular Teratoma
annotated property: has exact synonym
annotated target: Testicular Teratoma
term-group: DN
term-source: CTRP

Axiom
annotated source: Testicular Teratoma
annotated property: has exact synonym
annotated target: Testicular Teratoma
term-group: PT
term-source: NCI

Thyroid Gland Undifferentiated (Anaplastic) Carcinoma
type: Class
definition: A primary carcinoma of the thyroid gland composed of undifferentiated cells. The malignant cells demonstrate evidence of epithelial differentiation, either by immunohistochemistry or electron microscopic studies. Microscopically, in the majority of cases there is a mixture of spindle, epithelioid, and giant cells. The vast majority of the patients present with a rapidly enlarging neck mass. The clinical course is usually aggressive.
Has_NICHD_Parent: NCIT C3414
Concept_In_Subset: NCIT C102905
Concept_In_Subset: NCIT C103059
Concept_In_Subset: NCIT C116977
Concept_In_Subset: NCIT C118467
Concept_In_Subset: NCIT C126659
Concept_In_Subset: NCIT C90259
code: C3878
Semantic_Type: Neoplastic Process
Display_Name: Thyroid Gland Undifferentiated (Anaplastic) Cancer
Preferred_Name: Thyroid Gland Undifferentiated (Anaplastic) Carcinoma
UMLS_CUI: C0238461
Contributing_Source: CTEP
Contributing_Source: CTRP
Contributing_Source: NICHD
ALT_DEFINITION: A rare, aggressive type of thyroid cancer in which the malignant (cancer) cells look very different from normal thyroid cells.
ALT_DEFINITION: An aggressive carcinoma of the thyroid gland composed of undifferentiated cells.
Neoplastic_Status: Malignant
Legacy_Concept_Name: Anaplastic_Thyroid_Carcinoma
NICHD_Hierarchy_Term: Anaplastic Thyroid Carcinoma
has exact synonym: Anaplastic Carcinoma of Thyroid
has exact synonym: Anaplastic Carcinoma of Thyroid Gland
has exact synonym: Anaplastic Carcinoma of the Thyroid
has exact synonym: Anaplastic Carcinoma of the Thyroid Gland
has exact synonym: Anaplastic Thyroid Cancer
has exact synonym: Anaplastic Thyroid Carcinoma
has exact synonym: Anaplastic Thyroid Gland Carcinoma
has exact synonym: Anaplastic thyroid carcinoma
has exact synonym: Dedifferentiated Thyroid Gland Carcinoma
has exact synonym: Metaplastic Thyroid Gland Carcinoma
has exact synonym: Pleomorphic Thyroid Gland Carcinoma
has exact synonym: Sarcomatoid Thyroid Gland Carcinoma
has exact synonym: Thyroid Gland Carcinosarcoma
has exact synonym: Thyroid Gland Undifferentiated (Anaplastic) Carcinoma
has exact synonym: Undifferentiated (Anaplastic) Thyroid Gland Cancer
has exact synonym: Undifferentiated (Anaplastic) Thyroid Gland Carcinoma
has exact synonym: Undifferentiated Carcinoma of Thyroid
has exact synonym: Undifferentiated Carcinoma of Thyroid Gland
has exact synonym: Undifferentiated Carcinoma of the Thyroid
has exact synonym: Undifferentiated Carcinoma of the Thyroid Gland
has exact synonym: Undifferentiated Thyroid Carcinoma
has exact synonym: Undifferentiated Thyroid Gland Carcinoma
has exact synonym: Undifferentiated Thyroid Tumor
has exact synonym: anaplastic thyroid cancer
in subset: oncotree slim

Axiom
annotated source: Thyroid Gland Undifferentiated (Anaplastic) Carcinoma
annotated property: definition
annotated target: A primary carcinoma of the thyroid gland composed of undifferentiated cells. The malignant cells demonstrate evidence of epithelial differentiation, either by immunohistochemistry or electron microscopic studies. Microscopically, in the majority of cases there is a mixture of spindle, epithelioid, and giant cells. The vast majority of the patients present with a rapidly enlarging neck mass. The clinical course is usually aggressive.
def-source: NCI

Axiom
annotated source: Thyroid Gland Undifferentiated (Anaplastic) Carcinoma
annotated property: ALT_DEFINITION
annotated target: A rare, aggressive type of thyroid cancer in which the malignant (cancer) cells look very different from normal thyroid cells.
def-source: NCI-GLOSS

Axiom
annotated source: Thyroid Gland Undifferentiated (Anaplastic) Carcinoma
annotated property: ALT_DEFINITION
annotated target: An aggressive carcinoma of the thyroid gland composed of undifferentiated cells.
def-source: NICHD

Axiom
annotated source: Thyroid Gland Undifferentiated (Anaplastic) Carcinoma
annotated property: has exact synonym
annotated target: Anaplastic Carcinoma of Thyroid
term-group: SY
term-source: NCI

Axiom
annotated source: Thyroid Gland Undifferentiated (Anaplastic) Carcinoma
annotated property: has exact synonym
annotated target: Anaplastic Carcinoma of Thyroid Gland
term-group: SY
term-source: NCI

Axiom
annotated source: Thyroid Gland Undifferentiated (Anaplastic) Carcinoma
annotated property: has exact synonym
annotated target: Anaplastic Carcinoma of the Thyroid
term-group: SY
term-source: NCI

Axiom
annotated source: Thyroid Gland Undifferentiated (Anaplastic) Carcinoma
annotated property: has exact synonym
annotated target: Anaplastic Carcinoma of the Thyroid Gland
term-group: SY
term-source: NCI

Axiom
annotated source: Thyroid Gland Undifferentiated (Anaplastic) Carcinoma
annotated property: has exact synonym
annotated target: Anaplastic Thyroid Cancer
term-group: SY
term-source: NCI

Axiom
annotated source: Thyroid Gland Undifferentiated (Anaplastic) Carcinoma
annotated property: has exact synonym
annotated target: Anaplastic Thyroid Carcinoma
term-group: PT
term-source: NICHD

Axiom
annotated source: Thyroid Gland Undifferentiated (Anaplastic) Carcinoma
annotated property: has exact synonym
annotated target: Anaplastic Thyroid Carcinoma
term-group: SY
term-source: NCI

Axiom
annotated source: Thyroid Gland Undifferentiated (Anaplastic) Carcinoma
annotated property: has exact synonym
annotated target: Anaplastic Thyroid Gland Carcinoma
term-group: SY
term-source: NCI

Axiom
annotated source: Thyroid Gland Undifferentiated (Anaplastic) Carcinoma
annotated property: has exact synonym
annotated target: Anaplastic thyroid carcinoma
term-group: PT
term-source: CTEP
source-code: 10002240
subsource-name: SDC

Axiom
annotated source: Thyroid Gland Undifferentiated (Anaplastic) Carcinoma
annotated property: has exact synonym
annotated target: Dedifferentiated Thyroid Gland Carcinoma
term-group: SY
term-source: NCI

Axiom
annotated source: Thyroid Gland Undifferentiated (Anaplastic) Carcinoma
annotated property: has exact synonym
annotated target: Metaplastic Thyroid Gland Carcinoma
term-group: SY
term-source: NCI

Axiom
annotated source: Thyroid Gland Undifferentiated (Anaplastic) Carcinoma
annotated property: has exact synonym
annotated target: Pleomorphic Thyroid Gland Carcinoma
term-group: SY
term-source: NCI

Axiom
annotated source: Thyroid Gland Undifferentiated (Anaplastic) Carcinoma
annotated property: has exact synonym
annotated target: Sarcomatoid Thyroid Gland Carcinoma
term-group: SY
term-source: NCI

Axiom
annotated source: Thyroid Gland Undifferentiated (Anaplastic) Carcinoma
annotated property: has exact synonym
annotated target: Thyroid Gland Carcinosarcoma
term-group: SY
term-source: NCI

Axiom
annotated source: Thyroid Gland Undifferentiated (Anaplastic) Carcinoma
annotated property: has exact synonym
annotated target: Thyroid Gland Undifferentiated (Anaplastic) Carcinoma
term-group: PT
term-source: NCI

Axiom
annotated source: Thyroid Gland Undifferentiated (Anaplastic) Carcinoma
annotated property: has exact synonym
annotated target: Undifferentiated (Anaplastic) Thyroid Gland Cancer
term-group: DN
term-source: CTRP

Axiom
annotated source: Thyroid Gland Undifferentiated (Anaplastic) Carcinoma
annotated property: has exact synonym
annotated target: Undifferentiated (Anaplastic) Thyroid Gland Carcinoma
term-group: SY
term-source: NCI

Axiom
annotated source: Thyroid Gland Undifferentiated (Anaplastic) Carcinoma
annotated property: has exact synonym
annotated target: Undifferentiated Carcinoma of Thyroid
term-group: SY
term-source: NCI

Axiom
annotated source: Thyroid Gland Undifferentiated (Anaplastic) Carcinoma
annotated property: has exact synonym
annotated target: Undifferentiated Carcinoma of Thyroid Gland
term-group: SY
term-source: NCI

Axiom
annotated source: Thyroid Gland Undifferentiated (Anaplastic) Carcinoma
annotated property: has exact synonym
annotated target: Undifferentiated Carcinoma of the Thyroid
term-group: SY
term-source: NCI

Axiom
annotated source: Thyroid Gland Undifferentiated (Anaplastic) Carcinoma
annotated property: has exact synonym
annotated target: Undifferentiated Carcinoma of the Thyroid Gland
term-group: SY
term-source: NCI

Axiom
annotated source: Thyroid Gland Undifferentiated (Anaplastic) Carcinoma
annotated property: has exact synonym
annotated target: Undifferentiated Thyroid Carcinoma
term-group: SY
term-source: NCI

Axiom
annotated source: Thyroid Gland Undifferentiated (Anaplastic) Carcinoma
annotated property: has exact synonym
annotated target: Undifferentiated Thyroid Gland Carcinoma
term-group: SY
term-source: NCI

Axiom
annotated source: Thyroid Gland Undifferentiated (Anaplastic) Carcinoma
annotated property: has exact synonym
annotated target: Undifferentiated Thyroid Tumor
term-group: SY
term-source: NICHD

Axiom
annotated source: Thyroid Gland Undifferentiated (Anaplastic) Carcinoma
annotated property: has exact synonym
annotated target: anaplastic thyroid cancer
term-group: PT
term-source: NCI-GLOSS
source-code: CDR0000044541

Thyroid Gland Medullary Carcinoma
type: Class
definition: A neuroendocrine carcinoma arising from the C-cells of the thyroid gland. It is closely associated with multiple endocrine neoplasia syndromes. Approximately 10% to 20% of medullary thyroid carcinomas are familial. Patients usually present with a thyroid nodule that is painless and firm. In the majority of cases nodal involvement is present at diagnosis. Surgery is the preferred treatment for both primary lesions and recurrences. This carcinoma is generally not very sensitive to radiation and almost unresponsive to chemotherapy.
Has_NICHD_Parent: NCIT C3414
Concept_In_Subset: NCIT C102905
Concept_In_Subset: NCIT C103059
Concept_In_Subset: NCIT C116977
Concept_In_Subset: NCIT C118467
Concept_In_Subset: NCIT C126659
Concept_In_Subset: NCIT C61410
Concept_In_Subset: NCIT C77526
Concept_In_Subset: NCIT C88025
Concept_In_Subset: NCIT C90259
code: C3879
Semantic_Type: Neoplastic Process
Display_Name: Thyroid Gland Medullary Cancer
Preferred_Name: Thyroid Gland Medullary Carcinoma
UMLS_CUI: C0238462
Contributing_Source: CDISC
Contributing_Source: CTEP
Contributing_Source: CTRP
Contributing_Source: NICHD
ALT_DEFINITION: A neuroendocrine malignant epithelial neoplasm arising from C-cells of the thyroid gland.
ALT_DEFINITION: Cancer that develops in C cells of the thyroid. The C cells make a hormone (calcitonin) that helps maintain a healthy level of calcium in the blood.
ALT_DEFINITION: Carcinoma arising from the C-cells of the thyroid gland.
Neoplastic_Status: Malignant
Legacy_Concept_Name: Medullary_Thyroid_Carcinoma
NICHD_Hierarchy_Term: Medullary Thyroid Carcinoma
has exact synonym: C Cell Carcinoma
has exact synonym: CARCINOMA, C-CELL, MALIGNANT
has exact synonym: MTC
has exact synonym: Medullary Carcinoma
has exact synonym: Medullary Carcinoma of Thyroid
has exact synonym: Medullary Carcinoma of Thyroid Gland
has exact synonym: Medullary Carcinoma of the Thyroid
has exact synonym: Medullary Carcinoma of the Thyroid Gland
has exact synonym: Medullary Thyroid Cancer
has exact synonym: Medullary Thyroid Carcinoma
has exact synonym: Medullary Thyroid Gland Carcinoma
has exact synonym: Medullary thyroid carcinoma
has exact synonym: Parafollicular Cell Carcinoma
has exact synonym: Thyroid Gland Medullary Cancer
has exact synonym: Thyroid Gland Medullary Carcinoma
has exact synonym: Thyroid Gland Neuroendocrine Carcinoma
has exact synonym: Thyroid Medullary Carcinoma
has exact synonym: medullary thyroid cancer
in subset: oncotree slim

Axiom
annotated source: Thyroid Gland Medullary Carcinoma
annotated property: definition
annotated target: A neuroendocrine carcinoma arising from the C-cells of the thyroid gland. It is closely associated with multiple endocrine neoplasia syndromes. Approximately 10% to 20% of medullary thyroid carcinomas are familial. Patients usually present with a thyroid nodule that is painless and firm. In the majority of cases nodal involvement is present at diagnosis. Surgery is the preferred treatment for both primary lesions and recurrences. This carcinoma is generally not very sensitive to radiation and almost unresponsive to chemotherapy.
def-source: NCI

Axiom
annotated source: Thyroid Gland Medullary Carcinoma
annotated property: ALT_DEFINITION
annotated target: A neuroendocrine malignant epithelial neoplasm arising from C-cells of the thyroid gland.
def-source: CDISC

Axiom
annotated source: Thyroid Gland Medullary Carcinoma
annotated property: ALT_DEFINITION
annotated target: Cancer that develops in C cells of the thyroid. The C cells make a hormone (calcitonin) that helps maintain a healthy level of calcium in the blood.
def-source: NCI-GLOSS

Axiom
annotated source: Thyroid Gland Medullary Carcinoma
annotated property: ALT_DEFINITION
annotated target: Carcinoma arising from the C-cells of the thyroid gland.
def-source: NICHD

Axiom
annotated source: Thyroid Gland Medullary Carcinoma
annotated property: has exact synonym
annotated target: C Cell Carcinoma
term-group: SY
term-source: CDISC

Axiom
annotated source: Thyroid Gland Medullary Carcinoma
annotated property: has exact synonym
annotated target: C Cell Carcinoma
term-group: SY
term-source: NCI

Axiom
annotated source: Thyroid Gland Medullary Carcinoma
annotated property: has exact synonym
annotated target: C Cell Carcinoma
term-group: SY
term-source: NICHD

Axiom
annotated source: Thyroid Gland Medullary Carcinoma
annotated property: has exact synonym
annotated target: CARCINOMA, C-CELL, MALIGNANT
term-group: PT
term-source: CDISC

Axiom
annotated source: Thyroid Gland Medullary Carcinoma
annotated property: has exact synonym
annotated target: MTC
term-group: AB
term-source: NCI

Axiom
annotated source: Thyroid Gland Medullary Carcinoma
annotated property: has exact synonym
annotated target: MTC
term-group: SY
term-source: CDISC

Axiom
annotated source: Thyroid Gland Medullary Carcinoma
annotated property: has exact synonym
annotated target: Medullary Carcinoma
term-group: SY
term-source: CDISC

Axiom
annotated source: Thyroid Gland Medullary Carcinoma
annotated property: has exact synonym
annotated target: Medullary Carcinoma
term-group: SY
term-source: NCI

Axiom
annotated source: Thyroid Gland Medullary Carcinoma
annotated property: has exact synonym
annotated target: Medullary Carcinoma of Thyroid
term-group: SY
term-source: CDISC

Axiom
annotated source: Thyroid Gland Medullary Carcinoma
annotated property: has exact synonym
annotated target: Medullary Carcinoma of Thyroid
term-group: SY
term-source: NCI

Axiom
annotated source: Thyroid Gland Medullary Carcinoma
annotated property: has exact synonym
annotated target: Medullary Carcinoma of Thyroid Gland
term-group: SY
term-source: CDISC

Axiom
annotated source: Thyroid Gland Medullary Carcinoma
annotated property: has exact synonym
annotated target: Medullary Carcinoma of Thyroid Gland
term-group: SY
term-source: NCI

Axiom
annotated source: Thyroid Gland Medullary Carcinoma
annotated property: has exact synonym
annotated target: Medullary Carcinoma of the Thyroid
term-group: SY
term-source: CDISC

Axiom
annotated source: Thyroid Gland Medullary Carcinoma
annotated property: has exact synonym
annotated target: Medullary Carcinoma of the Thyroid
term-group: SY
term-source: NCI

Axiom
annotated source: Thyroid Gland Medullary Carcinoma
annotated property: has exact synonym
annotated target: Medullary Carcinoma of the Thyroid Gland
term-group: SY
term-source: CDISC

Axiom
annotated source: Thyroid Gland Medullary Carcinoma
annotated property: has exact synonym
annotated target: Medullary Carcinoma of the Thyroid Gland
term-group: SY
term-source: NCI

Axiom
annotated source: Thyroid Gland Medullary Carcinoma
annotated property: has exact synonym
annotated target: Medullary Thyroid Cancer
term-group: SY
term-source: CDISC

Axiom
annotated source: Thyroid Gland Medullary Carcinoma
annotated property: has exact synonym
annotated target: Medullary Thyroid Cancer
term-group: SY
term-source: NCI

Axiom
annotated source: Thyroid Gland Medullary Carcinoma
annotated property: has exact synonym
annotated target: Medullary Thyroid Carcinoma
term-group: PT
term-source: NICHD

Axiom
annotated source: Thyroid Gland Medullary Carcinoma
annotated property: has exact synonym
annotated target: Medullary Thyroid Carcinoma
term-group: SY
term-source: CDISC

Axiom
annotated source: Thyroid Gland Medullary Carcinoma
annotated property: has exact synonym
annotated target: Medullary Thyroid Carcinoma
term-group: SY
term-source: NCI

Axiom
annotated source: Thyroid Gland Medullary Carcinoma
annotated property: has exact synonym
annotated target: Medullary Thyroid Gland Carcinoma
term-group: SY
term-source: CDISC

Axiom
annotated source: Thyroid Gland Medullary Carcinoma
annotated property: has exact synonym
annotated target: Medullary Thyroid Gland Carcinoma
term-group: SY
term-source: NCI

Axiom
annotated source: Thyroid Gland Medullary Carcinoma
annotated property: has exact synonym
annotated target: Medullary thyroid carcinoma
term-group: PT
term-source: CTEP
source-code: 10027105
subsource-name: SDC

Axiom
annotated source: Thyroid Gland Medullary Carcinoma
annotated property: has exact synonym
annotated target: Parafollicular Cell Carcinoma
term-group: SY
term-source: CDISC

Axiom
annotated source: Thyroid Gland Medullary Carcinoma
annotated property: has exact synonym
annotated target: Parafollicular Cell Carcinoma
term-group: SY
term-source: NCI

Axiom
annotated source: Thyroid Gland Medullary Carcinoma
annotated property: has exact synonym
annotated target: Thyroid Gland Medullary Cancer
term-group: DN
term-source: CTRP

Axiom
annotated source: Thyroid Gland Medullary Carcinoma
annotated property: has exact synonym
annotated target: Thyroid Gland Medullary Carcinoma
term-group: PT
term-source: NCI

Axiom
annotated source: Thyroid Gland Medullary Carcinoma
annotated property: has exact synonym
annotated target: Thyroid Gland Medullary Carcinoma
term-group: SY
term-source: NCI
source-code: TCGA
subsource-name: caDSR

Axiom
annotated source: Thyroid Gland Medullary Carcinoma
annotated property: has exact synonym
annotated target: Thyroid Gland Neuroendocrine Carcinoma
term-group: SY
term-source: CDISC

Axiom
annotated source: Thyroid Gland Medullary Carcinoma
annotated property: has exact synonym
annotated target: Thyroid Gland Neuroendocrine Carcinoma
term-group: SY
term-source: NCI

Axiom
annotated source: Thyroid Gland Medullary Carcinoma
annotated property: has exact synonym
annotated target: Thyroid Medullary Carcinoma
term-group: SY
term-source: CDISC

Axiom
annotated source: Thyroid Gland Medullary Carcinoma
annotated property: has exact synonym
annotated target: Thyroid Medullary Carcinoma
term-group: SY
term-source: NCI

Axiom
annotated source: Thyroid Gland Medullary Carcinoma
annotated property: has exact synonym
annotated target: medullary thyroid cancer
term-group: PT
term-source: NCI-GLOSS
source-code: CDR0000044550

Kidney Angiomyolipoma
type: Class
definition: An angiomyolipoma arising from the kidney.
code: C3888
Semantic_Type: Neoplastic Process
Preferred_Name: Kidney Angiomyolipoma
UMLS_CUI: C0241961
Neoplastic_Status: Benign
Legacy_Concept_Name: Renal_Angiomyolipoma
has exact synonym: Angiomyolipoma of Kidney
has exact synonym: Angiomyolipoma of the Kidney
has exact synonym: Kidney Angiomyolipoma
has exact synonym: Renal Angiomyolipoma
in subset: oncotree slim

Axiom
annotated source: Kidney Angiomyolipoma
annotated property: definition
annotated target: An angiomyolipoma arising from the kidney.
def-source: NCI

Axiom
annotated source: Kidney Angiomyolipoma
annotated property: has exact synonym
annotated target: Angiomyolipoma of Kidney
term-group: SY
term-source: NCI

Axiom
annotated source: Kidney Angiomyolipoma
annotated property: has exact synonym
annotated target: Angiomyolipoma of the Kidney
term-group: SY
term-source: NCI

Axiom
annotated source: Kidney Angiomyolipoma
annotated property: has exact synonym
annotated target: Kidney Angiomyolipoma
term-group: PT
term-source: NCI

Axiom
annotated source: Kidney Angiomyolipoma
annotated property: has exact synonym
annotated target: Renal Angiomyolipoma
term-group: SY
term-source: NCI

Extranodal Marginal Zone Lymphoma of Mucosa-Associated Lymphoid Tissue
type: Class
subclass of: Marginal Zone Lymphoma
definition: An indolent, extranodal type of non-Hodgkin lymphoma composed of small B-lymphocytes (centrocyte-like cells). The gastrointestinal tract is the most common site of involvement. Other common sites of involvement include lung, head and neck, ocular adnexae, skin, thyroid, and breast. Gastric involvement is associated with the presence of H. pylori infection. (WHO, 2001)
Concept_In_Subset: NCIT C102905
Concept_In_Subset: NCIT C103133
Concept_In_Subset: NCIT C116977
Concept_In_Subset: NCIT C126659
code: C3898
Semantic_Type: Neoplastic Process
Display_Name: Extranodal Marginal Zone Lymphoma of Mucosa-Associated Lymphoid Tissue
Preferred_Name: Extranodal Marginal Zone Lymphoma of Mucosa-Associated Lymphoid Tissue
UMLS_CUI: C0242647
Contributing_Source: CTEP
Contributing_Source: CTRP
ALT_DEFINITION: A type of cancer that arises in cells in mucosal tissue that are involved in antibody production.
ICD-O-3_Code: 9699/3
Neoplastic_Status: Malignant
Legacy_Concept_Name: Extranodal_Marginal_Zone_B-Cell_Lymphoma_of_Mucosa-Associated_Lymphoid_Tissue
has exact synonym: Extranodal Marginal Zone B-Cell Lymphoma of Mucosa-Associated Lymphoid Tissue
has exact synonym: Extranodal Marginal Zone Lymphoma of Mucosa-Associated Lymphoid Tissue
has exact synonym: Extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue (MALT-lymphoma)
has exact synonym: Immunocytoma
has exact synonym: MALT Lymphoma
has exact synonym: MALT lymphoma
has exact synonym: MALT-lymphoma
has exact synonym: MALToma
has exact synonym: Mucosa-Associated Lymphoid Tissue Lymphoma
has exact synonym: mucosa-associated lymphoid tissue lymphoma
in subset: oncotree slim

Axiom
annotated source: Extranodal Marginal Zone Lymphoma of Mucosa-Associated Lymphoid Tissue
annotated property: definition
annotated target: An indolent, extranodal type of non-Hodgkin lymphoma composed of small B-lymphocytes (centrocyte-like cells). The gastrointestinal tract is the most common site of involvement. Other common sites of involvement include lung, head and neck, ocular adnexae, skin, thyroid, and breast. Gastric involvement is associated with the presence of H. pylori infection. (WHO, 2001)
def-source: NCI

Axiom
annotated source: Extranodal Marginal Zone Lymphoma of Mucosa-Associated Lymphoid Tissue
annotated property: ALT_DEFINITION
annotated target: A type of cancer that arises in cells in mucosal tissue that are involved in antibody production.
def-source: NCI-GLOSS

Axiom
annotated source: Extranodal Marginal Zone Lymphoma of Mucosa-Associated Lymphoid Tissue
annotated property: has exact synonym
annotated target: Extranodal Marginal Zone B-Cell Lymphoma of Mucosa-Associated Lymphoid Tissue
term-group: SY
term-source: NCI

Axiom
annotated source: Extranodal Marginal Zone Lymphoma of Mucosa-Associated Lymphoid Tissue
annotated property: has exact synonym
annotated target: Extranodal Marginal Zone Lymphoma of Mucosa-Associated Lymphoid Tissue
term-group: DN
term-source: CTRP

Axiom
annotated source: Extranodal Marginal Zone Lymphoma of Mucosa-Associated Lymphoid Tissue
annotated property: has exact synonym
annotated target: Extranodal Marginal Zone Lymphoma of Mucosa-Associated Lymphoid Tissue
term-group: PT
term-source: NCI

Axiom
annotated source: Extranodal Marginal Zone Lymphoma of Mucosa-Associated Lymphoid Tissue
annotated property: has exact synonym
annotated target: Extranodal Marginal Zone Lymphoma of Mucosa-Associated Lymphoid Tissue
term-group: SY
term-source: NCI
source-code: TCGA
subsource-name: caDSR

Axiom
annotated source: Extranodal Marginal Zone Lymphoma of Mucosa-Associated Lymphoid Tissue
annotated property: has exact synonym
annotated target: Extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue (MALT-lymphoma)
term-group: PT
term-source: CTEP
source-code: 10015822
subsource-name: SDC

Axiom
annotated source: Extranodal Marginal Zone Lymphoma of Mucosa-Associated Lymphoid Tissue
annotated property: has exact synonym
annotated target: Immunocytoma
term-group: AQS
term-source: NCI

Axiom
annotated source: Extranodal Marginal Zone Lymphoma of Mucosa-Associated Lymphoid Tissue
annotated property: has exact synonym
annotated target: MALT Lymphoma
term-group: SY
term-source: NCI

Axiom
annotated source: Extranodal Marginal Zone Lymphoma of Mucosa-Associated Lymphoid Tissue
annotated property: has exact synonym
annotated target: MALT lymphoma
term-group: PT
term-source: NCI-GLOSS
source-code: CDR0000045774

Axiom
annotated source: Extranodal Marginal Zone Lymphoma of Mucosa-Associated Lymphoid Tissue
annotated property: has exact synonym
annotated target: MALT-lymphoma
term-group: SY
term-source: CTEP
source-code: 10015822
subsource-name: SDC

Axiom
annotated source: Extranodal Marginal Zone Lymphoma of Mucosa-Associated Lymphoid Tissue
annotated property: has exact synonym
annotated target: MALToma
term-group: SY
term-source: NCI

Axiom
annotated source: Extranodal Marginal Zone Lymphoma of Mucosa-Associated Lymphoid Tissue
annotated property: has exact synonym
annotated target: Mucosa-Associated Lymphoid Tissue Lymphoma
term-group: SY
term-source: NCI

Axiom
annotated source: Extranodal Marginal Zone Lymphoma of Mucosa-Associated Lymphoid Tissue
annotated property: has exact synonym
annotated target: mucosa-associated lymphoid tissue lymphoma
term-group: PT
term-source: NCI-GLOSS
source-code: CDR0000044437

Telangiectatic Osteosarcoma
type: Class
definition: An osteosarcoma usually arising from the metaphysis of long bones. It is characterized by the presence of a cystic architecture with blood-filled spaces. The prognosis is similar to that of conventional osteosarcoma.
Concept_In_Subset: NCIT C116977
code: C3902
Semantic_Type: Neoplastic Process
Display_Name: Telangiectatic Osteosarcoma
Preferred_Name: Telangiectatic Osteosarcoma
UMLS_CUI: C0259782
Contributing_Source: CTRP
ICD-O-3_Code: 9183/3
Neoplastic_Status: Malignant
Legacy_Concept_Name: Telangiectatic_Osteosarcoma
has exact synonym: Malignant Bone Aneurysm
has exact synonym: Telangiectatic Osteogenic Sarcoma
has exact synonym: Telangiectatic Osteosarcoma
in subset: oncotree slim

Axiom
annotated source: Telangiectatic Osteosarcoma
annotated property: definition
annotated target: An osteosarcoma usually arising from the metaphysis of long bones. It is characterized by the presence of a cystic architecture with blood-filled spaces. The prognosis is similar to that of conventional osteosarcoma.
def-source: NCI

Axiom
annotated source: Telangiectatic Osteosarcoma
annotated property: has exact synonym
annotated target: Malignant Bone Aneurysm
term-group: SY
term-source: NCI

Axiom
annotated source: Telangiectatic Osteosarcoma
annotated property: has exact synonym
annotated target: Telangiectatic Osteogenic Sarcoma
term-group: SY
term-source: NCI

Axiom
annotated source: Telangiectatic Osteosarcoma
annotated property: has exact synonym
annotated target: Telangiectatic Osteosarcoma
term-group: PT
term-source: NCI

Papillary Meningioma
type: Class
definition: A WHO grade III meningioma characterized by the predominance of a perivascular pseudopapillary pattern.
Concept_In_Subset: NCIT C126659
code: C3904
Semantic_Type: Neoplastic Process
Preferred_Name: Papillary Meningioma
UMLS_CUI: C3163622
ICD-O-3_Code: 9538/3
Neoplastic_Status: Malignant
Legacy_Concept_Name: Papillary_Meningioma
has exact synonym: Papillary Meningioma
in subset: oncotree slim

Axiom
annotated source: Papillary Meningioma
annotated property: definition
annotated target: A WHO grade III meningioma characterized by the predominance of a perivascular pseudopapillary pattern.
def-source: NCI

Axiom
annotated source: Papillary Meningioma
annotated property: has exact synonym
annotated target: Papillary Meningioma
term-group: PT
term-source: NCI

Axiom
annotated source: Papillary Meningioma
annotated property: has exact synonym
annotated target: Papillary Meningioma
term-group: SY
term-source: NCI
source-code: TCGA
subsource-name: caDSR

Ampulla of Vater Carcinoma
type: Class
definition: A carcinoma arising from the ampulla of Vater. The vast majority of cases are adenocarcinomas. Signs and symptoms include jaundice, abdominal pain, anorexia, nausea, vomiting, and weight loss.
Concept_In_Subset: NCIT C126659
code: C3908
Semantic_Type: Neoplastic Process
Preferred_Name: Ampulla of Vater Carcinoma
UMLS_CUI: C0262401
ALT_DEFINITION: Cancer that forms in the ampulla of Vater (an enlargement of the ducts from the liver and pancreas where they join and enter the small intestine). Symptoms include jaundice, abdominal pain, nausea, vomiting, and weight loss.
Neoplastic_Status: Malignant
Legacy_Concept_Name: Ampulla_of_Vater_Carcinoma
has exact synonym: Ampulla of Vater Cancer
has exact synonym: Ampulla of Vater Carcinoma
has exact synonym: Ampullary Carcinoma
has exact synonym: ampulla of Vater cancer
has exact synonym: ampullary cancer
in subset: oncotree slim

Axiom
annotated source: Ampulla of Vater Carcinoma
annotated property: definition
annotated target: A carcinoma arising from the ampulla of Vater. The vast majority of cases are adenocarcinomas. Signs and symptoms include jaundice, abdominal pain, anorexia, nausea, vomiting, and weight loss.
def-source: NCI

Axiom
annotated source: Ampulla of Vater Carcinoma
annotated property: ALT_DEFINITION
annotated target: Cancer that forms in the ampulla of Vater (an enlargement of the ducts from the liver and pancreas where they join and enter the small intestine). Symptoms include jaundice, abdominal pain, nausea, vomiting, and weight loss.
def-source: NCI-GLOSS

Axiom
annotated source: Ampulla of Vater Carcinoma
annotated property: has exact synonym
annotated target: Ampulla of Vater Cancer
term-group: DN
term-source: CTRP

Axiom
annotated source: Ampulla of Vater Carcinoma
annotated property: has exact synonym
annotated target: Ampulla of Vater Cancer
term-group: SY
term-source: NCI

Axiom
annotated source: Ampulla of Vater Carcinoma
annotated property: has exact synonym
annotated target: Ampulla of Vater Carcinoma
term-group: PT
term-source: NCI

Axiom
annotated source: Ampulla of Vater Carcinoma
annotated property: has exact synonym
annotated target: Ampullary Carcinoma
term-group: SY
term-source: NCI

Axiom
annotated source: Ampulla of Vater Carcinoma
annotated property: has exact synonym
annotated target: ampulla of Vater cancer
term-group: PT
term-source: NCI-GLOSS
source-code: CDR0000562548

Axiom
annotated source: Ampulla of Vater Carcinoma
annotated property: has exact synonym
annotated target: ampullary cancer
term-group: PT
term-source: NCI-GLOSS
source-code: CDR0000543929

Congenital Melanocytic Nevus
type: Class
definition: A melanocytic nevus that is present at birth. It may present as a small macular, papular, or plaque-like lesion or as a large brown to black hairy skin lesion.
Has_NICHD_Parent: NCIT C3262
Concept_In_Subset: NCIT C90259
Concept_In_Subset: NCIT C99147
code: C3944
Semantic_Type: Congenital Abnormality
Semantic_Type: Disease or Syndrome
Preferred_Name: Congenital Melanocytic Nevus
UMLS_CUI: C1318558
Contributing_Source: NICHD
Neoplastic_Status: Benign
Legacy_Concept_Name: Congenital_Melanocytic_Skin_Nevus
NICHD_Hierarchy_Term: Congenital Melanocytic Nevus
has exact synonym: Congenital Melanocytic Nevi
has exact synonym: Congenital Melanocytic Nevus
has exact synonym: Congenital Melanocytic Nevus of Skin
has exact synonym: Congenital Melanocytic Nevus of the Skin
has exact synonym: Congenital Nevus of Skin
has exact synonym: Congenital Nevus of the Skin
has exact synonym: Congenital Pigmented Melanocytic Nevus
has exact synonym: Congenital Pigmented Nevus of Skin
has exact synonym: Congenital Pigmented Nevus of the Skin
has exact synonym: Congenital Pigmented Skin Nevus
has exact synonym: Congenital Skin Nevus
in subset: oncotree slim

Axiom
annotated source: Congenital Melanocytic Nevus
annotated property: definition
annotated target: A melanocytic nevus that is present at birth. It may present as a small macular, papular, or plaque-like lesion or as a large brown to black hairy skin lesion.
def-source: NCI

Axiom
annotated source: Congenital Melanocytic Nevus
annotated property: has exact synonym
annotated target: Congenital Melanocytic Nevi
term-group: SY
term-source: NICHD

Axiom
annotated source: Congenital Melanocytic Nevus
annotated property: has exact synonym
annotated target: Congenital Melanocytic Nevus
term-group: PT
term-source: NCI

Axiom
annotated source: Congenital Melanocytic Nevus
annotated property: has exact synonym
annotated target: Congenital Melanocytic Nevus
term-group: PT
term-source: NICHD

Axiom
annotated source: Congenital Melanocytic Nevus
annotated property: has exact synonym
annotated target: Congenital Melanocytic Nevus of Skin
term-group: SY
term-source: NCI

Axiom
annotated source: Congenital Melanocytic Nevus
annotated property: has exact synonym
annotated target: Congenital Melanocytic Nevus of the Skin
term-group: SY
term-source: NCI

Axiom
annotated source: Congenital Melanocytic Nevus
annotated property: has exact synonym
annotated target: Congenital Nevus of Skin
term-group: SY
term-source: NCI

Axiom
annotated source: Congenital Melanocytic Nevus
annotated property: has exact synonym
annotated target: Congenital Nevus of the Skin
term-group: SY
term-source: NCI

Axiom
annotated source: Congenital Melanocytic Nevus
annotated property: has exact synonym
annotated target: Congenital Pigmented Melanocytic Nevus
term-group: SY
term-source: NICHD

Axiom
annotated source: Congenital Melanocytic Nevus
annotated property: has exact synonym
annotated target: Congenital Pigmented Nevus of Skin
term-group: SY
term-source: NCI

Axiom
annotated source: Congenital Melanocytic Nevus
annotated property: has exact synonym
annotated target: Congenital Pigmented Nevus of the Skin
term-group: SY
term-source: NCI

Axiom
annotated source: Congenital Melanocytic Nevus
annotated property: has exact synonym
annotated target: Congenital Pigmented Skin Nevus
term-group: SY
term-source: NCI

Axiom
annotated source: Congenital Melanocytic Nevus
annotated property: has exact synonym
annotated target: Congenital Skin Nevus
term-group: SY
term-source: NCI

Lung Inflammatory Myofibroblastic Tumor
type: Class
subclass of: Inflammatory Myofibroblastic Tumor
definition: An intermediate fibroblastic neoplasm arising from the lung. It is characterized by the presence of spindle-shaped fibroblasts and myofibroblasts, and a chronic inflammatory infiltrate composed of eosinophils, lymphocytes and plasma cells.
code: C39740
Semantic_Type: Neoplastic Process
Preferred_Name: Lung Inflammatory Myofibroblastic Tumor
UMLS_CUI: C1518038
ICD-O-3_Code: 8827/1
Neoplastic_Status: Undetermined
Legacy_Concept_Name: Lung_Inflammatory_Myofibroblastic_Tumor
has exact synonym: Lung Inflammatory Myofibroblastic Tumor
in subset: oncotree slim

Axiom
annotated source: Lung Inflammatory Myofibroblastic Tumor
annotated property: definition
annotated target: An intermediate fibroblastic neoplasm arising from the lung. It is characterized by the presence of spindle-shaped fibroblasts and myofibroblasts, and a chronic inflammatory infiltrate composed of eosinophils, lymphocytes and plasma cells.
def-source: NCI

Axiom
annotated source: Lung Inflammatory Myofibroblastic Tumor
annotated property: has exact synonym
annotated target: Lung Inflammatory Myofibroblastic Tumor
term-group: PT
term-source: NCI

Mucinous Tubular and Spindle Cell Carcinoma of the Kidney
type: Class
definition: A low grade carcinoma of the kidney characterized by the presence of tubules which are separated by mucinous stroma. Often the tubular structures have a spindle cell appearance. Patients are usually asymptomatic and occasionally they may present with hematuria or flank pain.
Concept_In_Subset: NCIT C126659
Concept_In_Subset: NCIT C61410
Concept_In_Subset: NCIT C77526
Concept_In_Subset: NCIT C88025
code: C39807
Semantic_Type: Neoplastic Process
Preferred_Name: Mucinous Tubular and Spindle Cell Carcinoma of the Kidney
UMLS_CUI: C1513719
Contributing_Source: CDISC
ALT_DEFINITION: A malignant neoplasm of the kidney, characterized by the presence of tubules.
ICD-O-3_Code: 0000/0
Neoplastic_Status: Malignant
Legacy_Concept_Name: Mucinous_Tubular_and_Spindle_Renal_Cell_Carcinoma
has exact synonym: CARCINOMA, RENAL, TUBULAR, MALIGNANT
has exact synonym: Mucinous Tubular and Spindle Cell Carcinoma of the Kidney
in subset: oncotree slim

Axiom
annotated source: Mucinous Tubular and Spindle Cell Carcinoma of the Kidney
annotated property: definition
annotated target: A low grade carcinoma of the kidney characterized by the presence of tubules which are separated by mucinous stroma. Often the tubular structures have a spindle cell appearance. Patients are usually asymptomatic and occasionally they may present with hematuria or flank pain.
def-source: NCI

Axiom
annotated source: Mucinous Tubular and Spindle Cell Carcinoma of the Kidney
annotated property: ALT_DEFINITION
annotated target: A malignant neoplasm of the kidney, characterized by the presence of tubules.
def-source: CDISC

Axiom
annotated source: Mucinous Tubular and Spindle Cell Carcinoma of the Kidney
annotated property: has exact synonym
annotated target: CARCINOMA, RENAL, TUBULAR, MALIGNANT
term-group: PT
term-source: CDISC

Axiom
annotated source: Mucinous Tubular and Spindle Cell Carcinoma of the Kidney
annotated property: has exact synonym
annotated target: Mucinous Tubular and Spindle Cell Carcinoma of the Kidney
term-group: PT
term-source: NCI

Axiom
annotated source: Mucinous Tubular and Spindle Cell Carcinoma of the Kidney
annotated property: has exact synonym
annotated target: Mucinous Tubular and Spindle Cell Carcinoma of the Kidney
term-group: SY
term-source: CDISC

Infiltrating Bladder Urothelial Carcinoma, Plasmacytoid Variant
type: Class
code: C39823
Semantic_Type: Neoplastic Process
Preferred_Name: Infiltrating Bladder Urothelial Carcinoma, Plasmacytoid Variant
UMLS_CUI: C1512742
Neoplastic_Status: Malignant
Legacy_Concept_Name: Infiltrating_Bladder_Urothelial_Carcinoma_Plasmacytoid_Variant
has exact synonym: Infiltrating Bladder Urothelial Carcinoma, Plasmacytoid Variant
in subset: oncotree slim

Axiom
annotated source: Infiltrating Bladder Urothelial Carcinoma, Plasmacytoid Variant
annotated property: has exact synonym
annotated target: Infiltrating Bladder Urothelial Carcinoma, Plasmacytoid Variant
term-group: PT
term-source: NCI

Infiltrating Bladder Urothelial Carcinoma Sarcomatoid Variant
type: Class
definition: An invasive transitional cell carcinoma of the bladder that exhibits spindle cell sarcomatoid features.
code: C39824
Semantic_Type: Neoplastic Process
Preferred_Name: Infiltrating Bladder Urothelial Carcinoma Sarcomatoid Variant
UMLS_CUI: C1512743
Neoplastic_Status: Malignant
Legacy_Concept_Name: Infiltrating_Bladder_Urothelial_Carcinoma_Sarcomatoid_Variant
has exact synonym: Infiltrating Bladder Urothelial Carcinoma Sarcomatoid Variant
in subset: oncotree slim

Axiom
annotated source: Infiltrating Bladder Urothelial Carcinoma Sarcomatoid Variant
annotated property: definition
annotated target: An invasive transitional cell carcinoma of the bladder that exhibits spindle cell sarcomatoid features.
def-source: NCI

Axiom
annotated source: Infiltrating Bladder Urothelial Carcinoma Sarcomatoid Variant
annotated property: has exact synonym
annotated target: Infiltrating Bladder Urothelial Carcinoma Sarcomatoid Variant
term-group: PT
term-source: NCI

Axiom
annotated source: Infiltrating Bladder Urothelial Carcinoma Sarcomatoid Variant
annotated property: has exact synonym
annotated target: Infiltrating Bladder Urothelial Carcinoma Sarcomatoid Variant
term-group: SY
term-source: NCI
source-code: TCGA
subsource-name: caDSR

Bladder Urachal Carcinoma
type: Class
code: C39842
Semantic_Type: Neoplastic Process
Preferred_Name: Bladder Urachal Carcinoma
UMLS_CUI: C1511205
Neoplastic_Status: Malignant
Legacy_Concept_Name: Bladder_Urachal_Carcinoma
has exact synonym: Bladder Urachal Cancer
has exact synonym: Bladder Urachal Carcinoma
in subset: oncotree slim

Axiom
annotated source: Bladder Urachal Carcinoma
annotated property: has exact synonym
annotated target: Bladder Urachal Cancer
term-group: DN
term-source: CTRP

Axiom
annotated source: Bladder Urachal Carcinoma
annotated property: has exact synonym
annotated target: Bladder Urachal Carcinoma
term-group: PT
term-source: NCI

Bladder Urothelial Carcinoma
type: Class
definition: The most common morphologic subtype of urinary bladder carcinoma (over 90% of cases). It arises from the transitional epithelium. It most often affects males in their sixth and seventh decades of life. Hematuria is the most common symptom at presentation. Pathologic stage is the strongest predictor of survival.
Concept_In_Subset: NCIT C116977
Concept_In_Subset: NCIT C126659
code: C39851
Semantic_Type: Neoplastic Process
Display_Name: Bladder Urothelial Cancer
Preferred_Name: Bladder Urothelial Carcinoma
UMLS_CUI: C0279680
Contributing_Source: CTRP
Neoplastic_Status: Malignant
Legacy_Concept_Name: Bladder_Urothelial_Carcinoma
has exact synonym: Bladder Transitional Cell Carcinoma
has exact synonym: Bladder Urothelial Cancer
has exact synonym: Bladder Urothelial Carcinoma
has exact synonym: Transitional Cell Carcinoma of the Urinary Bladder
has exact synonym: Urinary Bladder Transitional Cell Carcinoma
has exact synonym: Urinary Bladder Urothelial Carcinoma
has exact synonym: Urothelial Carcinoma of the Urinary Bladder
in subset: oncotree slim

Axiom
annotated source: Bladder Urothelial Carcinoma
annotated property: definition
annotated target: The most common morphologic subtype of urinary bladder carcinoma (over 90% of cases). It arises from the transitional epithelium. It most often affects males in their sixth and seventh decades of life. Hematuria is the most common symptom at presentation. Pathologic stage is the strongest predictor of survival.
def-source: NCI

Axiom
annotated source: Bladder Urothelial Carcinoma
annotated property: has exact synonym
annotated target: Bladder Transitional Cell Carcinoma
term-group: SY
term-source: NCI

Axiom
annotated source: Bladder Urothelial Carcinoma
annotated property: has exact synonym
annotated target: Bladder Urothelial Cancer
term-group: DN
term-source: CTRP

Axiom
annotated source: Bladder Urothelial Carcinoma
annotated property: has exact synonym
annotated target: Bladder Urothelial Carcinoma
term-group: PT
term-source: NCI

Axiom
annotated source: Bladder Urothelial Carcinoma
annotated property: has exact synonym
annotated target: Bladder Urothelial Carcinoma
term-group: SY
term-source: NCI
source-code: TCGA
subsource-name: caDSR

Axiom
annotated source: Bladder Urothelial Carcinoma
annotated property: has exact synonym
annotated target: Transitional Cell Carcinoma of the Urinary Bladder
term-group: SY
term-source: NCI

Axiom
annotated source: Bladder Urothelial Carcinoma
annotated property: has exact synonym
annotated target: Urinary Bladder Transitional Cell Carcinoma
term-group: SY
term-source: NCI

Axiom
annotated source: Bladder Urothelial Carcinoma
annotated property: has exact synonym
annotated target: Urinary Bladder Urothelial Carcinoma
term-group: SY
term-source: NCI

Axiom
annotated source: Bladder Urothelial Carcinoma
annotated property: has exact synonym
annotated target: Urothelial Carcinoma of the Urinary Bladder
term-group: SY
term-source: NCI

Brenner Tumor
type: Class
definition: A usually benign tumor composed of solid and cystic nests of epithelial cells resembling transitional epithelium; it is surrounded by an abundant stromal component that is dense and fibroblastic in nature.
code: C39954
Semantic_Type: Neoplastic Process
Preferred_Name: Brenner Tumor
NCI_META_CUI: CL323981
ICD-O-3_Code: 9000/0
Neoplastic_Status: Undetermined
Legacy_Concept_Name: Brenner_Tumor
has exact synonym: Brenner Tumor
in subset: oncotree slim

Axiom
annotated source: Brenner Tumor
annotated property: definition
annotated target: A usually benign tumor composed of solid and cystic nests of epithelial cells resembling transitional epithelium; it is surrounded by an abundant stromal component that is dense and fibroblastic in nature.
def-source: NCI

Axiom
annotated source: Brenner Tumor
annotated property: has exact synonym
annotated target: Brenner Tumor
term-group: PT
term-source: NCI

Ovarian Steroid Cell Tumor, Not Otherwise Specified
type: Class
definition: A steroid cell tumor that arises from the ovary and is defined by morphologic features that do not fit into the categories of Leydig cell tumor and stromal luteoma. These features include solid proliferations of polygonal neoplastic cells with eosinophilic and granular cytoplasm. Grossly, these tumors usually present as large and well circumscribed masses and are usually associated with androgenic manifestations. Approximately one third of the cases have a malignant clinical course.
code: C39979
Semantic_Type: Neoplastic Process
Preferred_Name: Ovarian Steroid Cell Tumor, Not Otherwise Specified
UMLS_CUI: C1518740
Neoplastic_Status: Undetermined
Legacy_Concept_Name: Ovarian_Steroid_Cell_Tumor_Not_Otherwise_Specified
has exact synonym: Ovarian Steroid Cell Tumor, NOS
has exact synonym: Ovarian Steroid Cell Tumor, Not Otherwise Specified
in subset: oncotree slim

Axiom
annotated source: Ovarian Steroid Cell Tumor, Not Otherwise Specified
annotated property: definition
annotated target: A steroid cell tumor that arises from the ovary and is defined by morphologic features that do not fit into the categories of Leydig cell tumor and stromal luteoma. These features include solid proliferations of polygonal neoplastic cells with eosinophilic and granular cytoplasm. Grossly, these tumors usually present as large and well circumscribed masses and are usually associated with androgenic manifestations. Approximately one third of the cases have a malignant clinical course.
def-source: NCI

Axiom
annotated source: Ovarian Steroid Cell Tumor, Not Otherwise Specified
annotated property: has exact synonym
annotated target: Ovarian Steroid Cell Tumor, NOS
term-group: SY
term-source: NCI

Axiom
annotated source: Ovarian Steroid Cell Tumor, Not Otherwise Specified
annotated property: has exact synonym
annotated target: Ovarian Steroid Cell Tumor, Not Otherwise Specified
term-group: PT
term-source: NCI

Ovarian Gonadoblastoma
type: Class
definition: A neoplasm that arises from the ovary and is composed of tissues that resemble dysgerminoma or seminoma and are admixed with sex cord tissues. It is found in children or young adults and usually is associated with secondary sex organs abnormalities. The majority of patients present as phenotypic females with virilization. The minority of patients present as phenotypic males with feminization. It typically affects both gonads. If a malignant germ cell component is present, it may metastasize to other anatomic sites.
Has_NICHD_Parent: NCIT C3754
Has_NICHD_Parent: NCIT C7321
Concept_In_Subset: NCIT C132009
Concept_In_Subset: NCIT C90259
code: C39985
Semantic_Type: Neoplastic Process
Preferred_Name: Ovarian Gonadoblastoma
UMLS_CUI: C1518716
Contributing_Source: NICHD
ALT_DEFINITION: A gonadoblastoma that occurs in the ovary.
Neoplastic_Status: Undetermined
Legacy_Concept_Name: Ovarian_Gonadoblastoma
NICHD_Hierarchy_Term: Ovarian Gonadoblastoma
has exact synonym: Ovarian Gonadoblastoma
in subset: oncotree slim

Axiom
annotated source: Ovarian Gonadoblastoma
annotated property: definition
annotated target: A neoplasm that arises from the ovary and is composed of tissues that resemble dysgerminoma or seminoma and are admixed with sex cord tissues. It is found in children or young adults and usually is associated with secondary sex organs abnormalities. The majority of patients present as phenotypic females with virilization. The minority of patients present as phenotypic males with feminization. It typically affects both gonads. If a malignant germ cell component is present, it may metastasize to other anatomic sites.
def-source: NCI

Axiom
annotated source: Ovarian Gonadoblastoma
annotated property: ALT_DEFINITION
annotated target: A gonadoblastoma that occurs in the ovary.
def-source: NICHD

Axiom
annotated source: Ovarian Gonadoblastoma
annotated property: has exact synonym
annotated target: Ovarian Gonadoblastoma
term-group: PT
term-source: NCI

Axiom
annotated source: Ovarian Gonadoblastoma
annotated property: has exact synonym
annotated target: Ovarian Gonadoblastoma
term-group: PT
term-source: NICHD

Ovarian Polyembryoma
type: Class
definition: A rare, malignant germ cell tumor arising from the ovary. It is characterized by the presence of embryoid bodies which resemble early embryos.
Concept_In_Subset: NCIT C116977
code: C39990
Semantic_Type: Neoplastic Process
Display_Name: Ovarian Polyembryoma
Preferred_Name: Ovarian Polyembryoma
UMLS_CUI: C1514199
Contributing_Source: CTRP
Neoplastic_Status: Malignant
Legacy_Concept_Name: Polyembryoma_of_the_Ovary
has exact synonym: Ovarian Polyembryoma
has exact synonym: Polyembryoma of the Ovary
in subset: oncotree slim

Axiom
annotated source: Ovarian Polyembryoma
annotated property: definition
annotated target: A rare, malignant germ cell tumor arising from the ovary. It is characterized by the presence of embryoid bodies which resemble early embryos.
def-source: NCI

Axiom
annotated source: Ovarian Polyembryoma
annotated property: has exact synonym
annotated target: Ovarian Polyembryoma
term-group: DN
term-source: CTRP

Axiom
annotated source: Ovarian Polyembryoma
annotated property: has exact synonym
annotated target: Ovarian Polyembryoma
term-group: PT
term-source: NCI

Axiom
annotated source: Ovarian Polyembryoma
annotated property: has exact synonym
annotated target: Polyembryoma of the Ovary
term-group: SY
term-source: NCI

Inflammatory Breast Carcinoma
type: Class
subclass of: NCIT C9245
definition: An advanced, invasive breast adenocarcinoma characterized by the presence of distinct changes in the overlying skin. These changes include diffuse erythema, edema, peau d'orange (skin of an orange) appearance, tenderness, induration, warmth, enlargement, and in some cases a palpable mass. The skin changes are the consequence of lymphatic obstruction from the underlying invasive breast adenocarcinoma. Microscopically, the dermal lymphatics show prominent infiltration by malignant cells. The invasive breast adenocarcinoma is usually of ductal, NOS type. There is not significant inflammatory cell infiltrate present, despite the name of this carcinoma.
Concept_In_Subset: NCIT C102905
Concept_In_Subset: NCIT C103041
Concept_In_Subset: NCIT C116977
Concept_In_Subset: NCIT C126659
code: C4001
Semantic_Type: Neoplastic Process
Display_Name: Inflammatory Breast Cancer
Preferred_Name: Inflammatory Breast Carcinoma
UMLS_CUI: C0278601
Contributing_Source: CTEP
Contributing_Source: CTRP
ALT_DEFINITION: A type of breast cancer in which the breast looks red and swollen and feels warm. The skin of the breast may also show the pitted appearance called peau d'orange (like the skin of an orange). The redness and warmth occur because the cancer cells block the lymph vessels in the skin.
ICD-O-3_Code: 8530/3
Neoplastic_Status: Malignant
Legacy_Concept_Name: Inflammatory_Breast_Carcinoma
has exact synonym: Inflammatory Breast Cancer
has exact synonym: Inflammatory Breast Carcinoma
has exact synonym: Inflammatory Carcinoma of Breast
has exact synonym: Inflammatory Carcinoma of the Breast
has exact synonym: Inflammatory breast carcinoma
has exact synonym: Mastitis Carcinomatosa
has exact synonym: inflammatory breast cancer
in subset: oncotree slim

Axiom
annotated source: Inflammatory Breast Carcinoma
annotated property: definition
annotated target: An advanced, invasive breast adenocarcinoma characterized by the presence of distinct changes in the overlying skin. These changes include diffuse erythema, edema, peau d'orange (skin of an orange) appearance, tenderness, induration, warmth, enlargement, and in some cases a palpable mass. The skin changes are the consequence of lymphatic obstruction from the underlying invasive breast adenocarcinoma. Microscopically, the dermal lymphatics show prominent infiltration by malignant cells. The invasive breast adenocarcinoma is usually of ductal, NOS type. There is not significant inflammatory cell infiltrate present, despite the name of this carcinoma.
def-source: NCI

Axiom
annotated source: Inflammatory Breast Carcinoma
annotated property: ALT_DEFINITION
annotated target: A type of breast cancer in which the breast looks red and swollen and feels warm. The skin of the breast may also show the pitted appearance called peau d'orange (like the skin of an orange). The redness and warmth occur because the cancer cells block the lymph vessels in the skin.
def-source: NCI-GLOSS

Axiom
annotated source: Inflammatory Breast Carcinoma
annotated property: has exact synonym
annotated target: Inflammatory Breast Cancer
term-group: SY
term-source: NCI

Axiom
annotated source: Inflammatory Breast Carcinoma
annotated property: has exact synonym
annotated target: Inflammatory Breast Carcinoma
term-group: PT
term-source: NCI

Axiom
annotated source: Inflammatory Breast Carcinoma
annotated property: has exact synonym
annotated target: Inflammatory Carcinoma of Breast
term-group: SY
term-source: NCI

Axiom
annotated source: Inflammatory Breast Carcinoma
annotated property: has exact synonym
annotated target: Inflammatory Carcinoma of the Breast
term-group: SY
term-source: NCI

Axiom
annotated source: Inflammatory Breast Carcinoma
annotated property: has exact synonym
annotated target: Inflammatory breast carcinoma
term-group: PT
term-source: CTEP
source-code: 10021980
subsource-name: SDC

Axiom
annotated source: Inflammatory Breast Carcinoma
annotated property: has exact synonym
annotated target: Mastitis Carcinomatosa
term-group: SY
term-source: NCI

Axiom
annotated source: Inflammatory Breast Carcinoma
annotated property: has exact synonym
annotated target: inflammatory breast cancer
term-group: PT
term-source: NCI-GLOSS
source-code: CDR0000045313

Borderline Ovarian Mucinous Tumor
type: Class
subclass of: Ovarian Mucinous Tumor
definition: A low grade mucinous epithelial neoplasm arising from the ovary. It is characterized by an atypical proliferation of mucinous-type epithelial cells without evidence of stromal invasion. The mucinous epithelial cells may be of intestinal or endocervical type.
Concept_In_Subset: NCIT C116977
code: C40036
Semantic_Type: Neoplastic Process
Display_Name: Borderline Ovarian Mucinous Tumor
Preferred_Name: Borderline Ovarian Mucinous Tumor
UMLS_CUI: C0279664
Contributing_Source: CTRP
Neoplastic_Status: Undetermined
Legacy_Concept_Name: Borderline_Ovarian_Mucinous_Tumor
has exact synonym: Borderline Ovarian Mucinous Neoplasm
has exact synonym: Borderline Ovarian Mucinous Tumor
in subset: oncotree slim

Axiom
annotated source: Borderline Ovarian Mucinous Tumor
annotated property: definition
annotated target: A low grade mucinous epithelial neoplasm arising from the ovary. It is characterized by an atypical proliferation of mucinous-type epithelial cells without evidence of stromal invasion. The mucinous epithelial cells may be of intestinal or endocervical type.
def-source: NCI

Axiom
annotated source: Borderline Ovarian Mucinous Tumor
annotated property: has exact synonym
annotated target: Borderline Ovarian Mucinous Neoplasm
term-group: SY
term-source: NCI

Axiom
annotated source: Borderline Ovarian Mucinous Tumor
annotated property: has exact synonym
annotated target: Borderline Ovarian Mucinous Tumor
term-group: PT
term-source: NCI

Borderline Ovarian Mucinous Tumor, Endocervical-Like
type: Class
subclass of: Borderline Ovarian Mucinous Tumor
definition: A neoplasm of low malignant potential arising from the ovary. It is characterized by the proliferation of neoplastic epithelial cells that resemble endocervical epithelial cells. There is no evidence of stromal invasion.
code: C40038
Semantic_Type: Neoplastic Process
Preferred_Name: Borderline Ovarian Mucinous Tumor, Endocervical-Like
UMLS_CUI: C1511264
Neoplastic_Status: Undetermined
Legacy_Concept_Name: Borderline_Ovarian_Mucinous_Tumor_Endocervical-like
has exact synonym: Borderline Ovarian Mucinous Tumor, Endocervical-Like
in subset: oncotree slim

Axiom
annotated source: Borderline Ovarian Mucinous Tumor, Endocervical-Like
annotated property: definition
annotated target: A neoplasm of low malignant potential arising from the ovary. It is characterized by the proliferation of neoplastic epithelial cells that resemble endocervical epithelial cells. There is no evidence of stromal invasion.
def-source: NCI

Axiom
annotated source: Borderline Ovarian Mucinous Tumor, Endocervical-Like
annotated property: has exact synonym
annotated target: Borderline Ovarian Mucinous Tumor, Endocervical-Like
term-group: PT
term-source: NCI

Gastric Adenocarcinoma
type: Class
definition: An adenocarcinoma arising from the stomach glandular epithelium. Gastric adenocarcinoma is primarily a disease of older individuals. It most commonly develops after a long period of atrophic gastritis and is strongly associated with Helicobacter pylori infection. The lack of early symptoms often delays the diagnosis of gastric cancer. The majority of patients present with advanced tumors which have poor rates of curability. Microscopically, two important histologic types of gastric adenocarcinoma are recognized: the intestinal and diffuse type. The overall prognosis of gastric adenocarcinomas is poor, even in patients who receive a "curative" resection (adapted from Sternberg's Surgical Pathology, 3rd ed., 1999).
Concept_In_Subset: NCIT C102905
Concept_In_Subset: NCIT C103064
Concept_In_Subset: NCIT C116977
Concept_In_Subset: NCIT C126659
code: C4004
Semantic_Type: Neoplastic Process
Display_Name: Gastric Adenocarcinoma
Preferred_Name: Gastric Adenocarcinoma
UMLS_CUI: C0278701
Contributing_Source: CTEP
Contributing_Source: CTRP
Neoplastic_Status: Malignant
Legacy_Concept_Name: Gastric_Adenocarcinoma
has exact synonym: Adenocarcinoma - stomach
has exact synonym: Adenocarcinoma of Stomach
has exact synonym: Adenocarcinoma of the Stomach
has exact synonym: Adenocarcinoma of the stomach
has exact synonym: Gastric (Stomach) Adenocarcinoma
has exact synonym: Gastric Adenocarcinoma
has exact synonym: Stomach Adenocarcinoma
in subset: oncotree slim

Axiom
annotated source: Gastric Adenocarcinoma
annotated property: definition
annotated target: An adenocarcinoma arising from the stomach glandular epithelium. Gastric adenocarcinoma is primarily a disease of older individuals. It most commonly develops after a long period of atrophic gastritis and is strongly associated with Helicobacter pylori infection. The lack of early symptoms often delays the diagnosis of gastric cancer. The majority of patients present with advanced tumors which have poor rates of curability. Microscopically, two important histologic types of gastric adenocarcinoma are recognized: the intestinal and diffuse type. The overall prognosis of gastric adenocarcinomas is poor, even in patients who receive a "curative" resection (adapted from Sternberg's Surgical Pathology, 3rd ed., 1999).
def-source: NCI

Axiom
annotated source: Gastric Adenocarcinoma
annotated property: has exact synonym
annotated target: Adenocarcinoma - stomach
term-group: SY
term-source: CTEP
source-code: 10001150
subsource-name: SDC

Axiom
annotated source: Gastric Adenocarcinoma
annotated property: has exact synonym
annotated target: Adenocarcinoma of Stomach
term-group: SY
term-source: NCI

Axiom
annotated source: Gastric Adenocarcinoma
annotated property: has exact synonym
annotated target: Adenocarcinoma of the Stomach
term-group: SY
term-source: NCI

Axiom
annotated source: Gastric Adenocarcinoma
annotated property: has exact synonym
annotated target: Adenocarcinoma of the stomach
term-group: PT
term-source: CTEP
source-code: 10001150
subsource-name: SDC

Axiom
annotated source: Gastric Adenocarcinoma
annotated property: has exact synonym
annotated target: Gastric (Stomach) Adenocarcinoma
term-group: DN
term-source: CTRP

Axiom
annotated source: Gastric Adenocarcinoma
annotated property: has exact synonym
annotated target: Gastric Adenocarcinoma
term-group: PT
term-source: NCI

Axiom
annotated source: Gastric Adenocarcinoma
annotated property: has exact synonym
annotated target: Gastric Adenocarcinoma
term-group: SY
term-source: NCI
source-code: TCGA
subsource-name: caDSR

Axiom
annotated source: Gastric Adenocarcinoma
annotated property: has exact synonym
annotated target: Stomach Adenocarcinoma
term-group: SY
term-source: NCI

Ovarian Clear Cell Tumor
type: Class
subclass of: Ovarian Epithelial Tumor
definition: A benign, borderline, or malignant epithelial tumor of the ovary that is characterized by a predominance of clear and hobnail cells.
code: C40076
Semantic_Type: Neoplastic Process
Preferred_Name: Ovarian Clear Cell Tumor
UMLS_CUI: C0346164
Neoplastic_Status: Undetermined
Legacy_Concept_Name: Ovarian_Clear_Cell_Tumor
has exact synonym: Ovarian Clear Cell Neoplasm
has exact synonym: Ovarian Clear Cell Tumor
in subset: oncotree slim

Axiom
annotated source: Ovarian Clear Cell Tumor
annotated property: definition
annotated target: A benign, borderline, or malignant epithelial tumor of the ovary that is characterized by a predominance of clear and hobnail cells.
def-source: NCI

Axiom
annotated source: Ovarian Clear Cell Tumor
annotated property: has exact synonym
annotated target: Ovarian Clear Cell Neoplasm
term-group: SY
term-source: NCI

Axiom
annotated source: Ovarian Clear Cell Tumor
annotated property: has exact synonym
annotated target: Ovarian Clear Cell Tumor
term-group: PT
term-source: NCI

Borderline Ovarian Clear Cell Tumor
type: Class
subclass of: Ovarian Clear Cell Tumor
definition: An epithelial neoplasm with low malignant potential affecting the ovary. It is characterized by the presence of clear or hobnail cells. In some cases, the cells may display nuclear atypia and prominent nucleoli. When such cells are present, they remain confined to the glands. There is no evidence of stromal invasion.
Concept_In_Subset: NCIT C116977
code: C40080
Semantic_Type: Neoplastic Process
Display_Name: Borderline Ovarian Clear Cell Tumor
Preferred_Name: Borderline Ovarian Clear Cell Tumor
UMLS_CUI: C0279676
Contributing_Source: CTRP
Neoplastic_Status: Undetermined
Legacy_Concept_Name: Borderline_Ovarian_Clear_Cell_Tumor
has exact synonym: Borderline Ovarian Clear Cell Neoplasm
has exact synonym: Borderline Ovarian Clear Cell Tumor
in subset: oncotree slim

Axiom
annotated source: Borderline Ovarian Clear Cell Tumor
annotated property: definition
annotated target: An epithelial neoplasm with low malignant potential affecting the ovary. It is characterized by the presence of clear or hobnail cells. In some cases, the cells may display nuclear atypia and prominent nucleoli. When such cells are present, they remain confined to the glands. There is no evidence of stromal invasion.
def-source: NCI

Axiom
annotated source: Borderline Ovarian Clear Cell Tumor
annotated property: has exact synonym
annotated target: Borderline Ovarian Clear Cell Neoplasm
term-group: SY
term-source: NCI

Axiom
annotated source: Borderline Ovarian Clear Cell Tumor
annotated property: has exact synonym
annotated target: Borderline Ovarian Clear Cell Tumor
term-group: PT
term-source: NCI

Ovarian Seromucinous Carcinoma
type: Class
definition: A malignant mixed epithelial neoplasm that arises from the ovary and is composed predominantly of serous and endocervical-type mucinous epithelium.
Concept_In_Subset: NCIT C116977
code: C40090
Semantic_Type: Neoplastic Process
Display_Name: Malignant Ovarian Mixed Epithelial Tumor
Preferred_Name: Ovarian Seromucinous Carcinoma
UMLS_CUI: C0279392
Contributing_Source: CTRP
Neoplastic_Status: Malignant
Legacy_Concept_Name: Malignant_Ovarian_Mixed_Epithelial_Tumor
has exact synonym: Malignant Ovarian Mixed Epithelial Neoplasm
has exact synonym: Malignant Ovarian Mixed Epithelial Tumor
has exact synonym: Mixed Epithelial Carcinoma of Ovary
has exact synonym: Mixed Epithelial Carcinoma of the Ovary
has exact synonym: Ovarian Mixed Epithelial Carcinoma
has exact synonym: Ovarian Seromucinous Carcinoma
in subset: oncotree slim

Axiom
annotated source: Ovarian Seromucinous Carcinoma
annotated property: definition
annotated target: A malignant mixed epithelial neoplasm that arises from the ovary and is composed predominantly of serous and endocervical-type mucinous epithelium.
def-source: NCI

Axiom
annotated source: Ovarian Seromucinous Carcinoma
annotated property: has exact synonym
annotated target: Malignant Ovarian Mixed Epithelial Neoplasm
term-group: SY
term-source: NCI

Axiom
annotated source: Ovarian Seromucinous Carcinoma
annotated property: has exact synonym
annotated target: Malignant Ovarian Mixed Epithelial Tumor
term-group: SY
term-source: NCI

Axiom
annotated source: Ovarian Seromucinous Carcinoma
annotated property: has exact synonym
annotated target: Mixed Epithelial Carcinoma of Ovary
term-group: SY
term-source: NCI

Axiom
annotated source: Ovarian Seromucinous Carcinoma
annotated property: has exact synonym
annotated target: Mixed Epithelial Carcinoma of the Ovary
term-group: SY
term-source: NCI

Axiom
annotated source: Ovarian Seromucinous Carcinoma
annotated property: has exact synonym
annotated target: Ovarian Mixed Epithelial Carcinoma
term-group: SY
term-source: NCI

Axiom
annotated source: Ovarian Seromucinous Carcinoma
annotated property: has exact synonym
annotated target: Ovarian Seromucinous Carcinoma
term-group: PT
term-source: NCI

Endometrial Mucinous Adenocarcinoma
type: Class
subclass of: Mucinous Adenocarcinoma
definition: A primary, usually low grade adenocarcinoma of the endometrium in which the majority of the malignant epithelial cells contain abundant intracytoplasmic mucin.
Concept_In_Subset: NCIT C126659
code: C40144
Semantic_Type: Neoplastic Process
Preferred_Name: Endometrial Mucinous Adenocarcinoma
UMLS_CUI: C0854923
Neoplastic_Status: Malignant
Legacy_Concept_Name: Uterine_Corpus_Mucinous_Adenocarcinoma
has exact synonym: Endometrial Mucinous Adenocarcinoma
has exact synonym: Uterine Corpus Mucinous Adenocarcinoma
in subset: oncotree slim

Axiom
annotated source: Endometrial Mucinous Adenocarcinoma
annotated property: definition
annotated target: A primary, usually low grade adenocarcinoma of the endometrium in which the majority of the malignant epithelial cells contain abundant intracytoplasmic mucin.
def-source: NCI

Axiom
annotated source: Endometrial Mucinous Adenocarcinoma
annotated property: has exact synonym
annotated target: Endometrial Mucinous Adenocarcinoma
term-group: PT
term-source: NCI

Axiom
annotated source: Endometrial Mucinous Adenocarcinoma
annotated property: has exact synonym
annotated target: Uterine Corpus Mucinous Adenocarcinoma
term-group: SY
term-source: NCI

Uterine Corpus Epithelioid Leiomyosarcoma
type: Class
subclass of: Uterine Corpus Leiomyosarcoma
definition: A morphologic variant of leiomyosarcoma arising from the uterine corpus. It is characterized by the presence of epithelioid round cells with eosinophilic to clear cytoplasm.
code: C40174
Semantic_Type: Neoplastic Process
Preferred_Name: Uterine Corpus Epithelioid Leiomyosarcoma
UMLS_CUI: C1519851
Neoplastic_Status: Malignant
Legacy_Concept_Name: Uterine_Corpus_Epithelioid_Leiomyosarcoma
has exact synonym: Uterine Corpus Epithelioid Leiomyosarcoma
in subset: oncotree slim

Axiom
annotated source: Uterine Corpus Epithelioid Leiomyosarcoma
annotated property: definition
annotated target: A morphologic variant of leiomyosarcoma arising from the uterine corpus. It is characterized by the presence of epithelioid round cells with eosinophilic to clear cytoplasm.
def-source: NCI

Axiom
annotated source: Uterine Corpus Epithelioid Leiomyosarcoma
annotated property: has exact synonym
annotated target: Uterine Corpus Epithelioid Leiomyosarcoma
term-group: PT
term-source: NCI

Uterine Corpus Myxoid Leiomyosarcoma
type: Class
subclass of: Uterine Corpus Leiomyosarcoma
definition: A morphologic variant of leiomyosarcoma arising from the uterus corpus. It is characterized by the presence of cellular pleomorphism, malignant cells with large nuclei, and a myxoid stroma.
code: C40175
Semantic_Type: Neoplastic Process
Preferred_Name: Uterine Corpus Myxoid Leiomyosarcoma
UMLS_CUI: C1519861
Neoplastic_Status: Malignant
Legacy_Concept_Name: Uterine_Corpus_Myxoid_Leiomyosarcoma
has exact synonym: Uterine Corpus Myxoid Leiomyosarcoma
in subset: oncotree slim

Axiom
annotated source: Uterine Corpus Myxoid Leiomyosarcoma
annotated property: definition
annotated target: A morphologic variant of leiomyosarcoma arising from the uterus corpus. It is characterized by the presence of cellular pleomorphism, malignant cells with large nuclei, and a myxoid stroma.
def-source: NCI

Axiom
annotated source: Uterine Corpus Myxoid Leiomyosarcoma
annotated property: has exact synonym
annotated target: Uterine Corpus Myxoid Leiomyosarcoma
term-group: PT
term-source: NCI

Uterine Corpus Smooth Muscle Neoplasm
type: Class
definition: A benign, intermediate, or malignant neoplasm that arises from the uterine corpus and is composed of neoplastic cells with smooth muscle differentiation.
code: C40176
Semantic_Type: Neoplastic Process
Preferred_Name: Uterine Corpus Smooth Muscle Neoplasm
UMLS_CUI: C1519863
Neoplastic_Status: Undetermined
Legacy_Concept_Name: Uterine_Corpus_Smooth_Muscle_Neoplasm
has exact synonym: Uterine Corpus Smooth Muscle Neoplasm
in subset: oncotree slim

Axiom
annotated source: Uterine Corpus Smooth Muscle Neoplasm
annotated property: definition
annotated target: A benign, intermediate, or malignant neoplasm that arises from the uterine corpus and is composed of neoplastic cells with smooth muscle differentiation.
def-source: NCI

Axiom
annotated source: Uterine Corpus Smooth Muscle Neoplasm
annotated property: has exact synonym
annotated target: Uterine Corpus Smooth Muscle Neoplasm
term-group: PT
term-source: NCI

Uterine Corpus Smooth Muscle Tumor of Uncertain Malignant Potential
type: Class
subclass of: Uterine Corpus Smooth Muscle Neoplasm
definition: A smooth muscle neoplasm which arises from the uterine corpus and can not be reliably diagnosed as benign or malignant, because of the presence of ambiguous morphologic findings.
code: C40177
Semantic_Type: Neoplastic Process
Preferred_Name: Uterine Corpus Smooth Muscle Tumor of Uncertain Malignant Potential
UMLS_CUI: C1519864
ICD-O-3_Code: 8897/1
Neoplastic_Status: Uncertain Malignant Potential
Legacy_Concept_Name: Uterine_Corpus_Smooth_Muscle_Neoplasm_of_Uncertain_Malignant_Potential
has exact synonym: Borderline Uterine Corpus Smooth Muscle Neoplasm
has exact synonym: Uterine Corpus STUMP
has exact synonym: Uterine Corpus Smooth Muscle Neoplasm of Uncertain Malignant Potential
has exact synonym: Uterine Corpus Smooth Muscle Tumor of Uncertain Malignant Potential
in subset: oncotree slim

Axiom
annotated source: Uterine Corpus Smooth Muscle Tumor of Uncertain Malignant Potential
annotated property: definition
annotated target: A smooth muscle neoplasm which arises from the uterine corpus and can not be reliably diagnosed as benign or malignant, because of the presence of ambiguous morphologic findings.
def-source: NCI

Axiom
annotated source: Uterine Corpus Smooth Muscle Tumor of Uncertain Malignant Potential
annotated property: has exact synonym
annotated target: Borderline Uterine Corpus Smooth Muscle Neoplasm
term-group: SY
term-source: NCI

Axiom
annotated source: Uterine Corpus Smooth Muscle Tumor of Uncertain Malignant Potential
annotated property: has exact synonym
annotated target: Uterine Corpus STUMP
term-group: AB
term-source: NCI

Axiom
annotated source: Uterine Corpus Smooth Muscle Tumor of Uncertain Malignant Potential
annotated property: has exact synonym
annotated target: Uterine Corpus Smooth Muscle Neoplasm of Uncertain Malignant Potential
term-group: SY
term-source: NCI

Axiom
annotated source: Uterine Corpus Smooth Muscle Tumor of Uncertain Malignant Potential
annotated property: has exact synonym
annotated target: Uterine Corpus Smooth Muscle Tumor of Uncertain Malignant Potential
term-group: PT
term-source: NCI

Lobular Breast Carcinoma In Situ
type: Class
definition: A non-invasive adenocarcinoma of the breast characterized by a proliferation of monomorphic cells completely filling the lumina. The overall lobular architecture is preserved. It is frequently multifocal (90% in some series) and bilateral. It seldom becomes invasive; however there is an increased risk of infiltrating ductal adenocarcinoma.
Concept_In_Subset: NCIT C102905
Concept_In_Subset: NCIT C103040
Concept_In_Subset: NCIT C116977
Concept_In_Subset: NCIT C126659
code: C4018
Semantic_Type: Neoplastic Process
Display_Name: Lobular Breast Carcinoma In Situ
Preferred_Name: Lobular Breast Carcinoma In Situ
UMLS_CUI: C0279563
Contributing_Source: CTEP
Contributing_Source: CTRP
ALT_DEFINITION: A condition in which abnormal cells are found in the lobules of the breast. Lobular carcinoma in situ seldom becomes invasive cancer; however, having it in one breast increases the risk of developing breast cancer in either breast.
ICD-O-3_Code: 8520/2
Neoplastic_Status: Malignant
Legacy_Concept_Name: Lobular_Carcinoma_in_situ_of_the_Breast
has exact synonym: LCIS
has exact synonym: Lobular Breast Carcinoma In Situ
has exact synonym: Lobular Ca in situ of Breast
has exact synonym: Lobular Ca in situ of the Breast
has exact synonym: Lobular Carcinoma In Situ (LCIS)
has exact synonym: Lobular Carcinoma In Situ of the Breast
has exact synonym: Lobular Carcinoma In Situ of the Breast (LCIS)
has exact synonym: Lobular Carcinoma in situ
has exact synonym: Lobular Carcinoma in situ of Breast
has exact synonym: Lobular carcinoma in situ
has exact synonym: Non-Infiltrating Lobular Breast Carcinoma
has exact synonym: Non-Infiltrating Lobular Carcinoma
has exact synonym: Non-Infiltrating Lobular Carcinoma of Breast
has exact synonym: Non-Infiltrating Lobular Carcinoma of the Breast
has exact synonym: Non-Invasive Lobular Breast Carcinoma
has exact synonym: Non-Invasive Lobular Carcinoma of Breast
has exact synonym: Non-Invasive Lobular Carcinoma of the Breast
has exact synonym: lobular carcinoma in situ
in subset: oncotree slim

Axiom
annotated source: Lobular Breast Carcinoma In Situ
annotated property: definition
annotated target: A non-invasive adenocarcinoma of the breast characterized by a proliferation of monomorphic cells completely filling the lumina. The overall lobular architecture is preserved. It is frequently multifocal (90% in some series) and bilateral. It seldom becomes invasive; however there is an increased risk of infiltrating ductal adenocarcinoma.
def-source: NCI

Axiom
annotated source: Lobular Breast Carcinoma In Situ
annotated property: ALT_DEFINITION
annotated target: A condition in which abnormal cells are found in the lobules of the breast. Lobular carcinoma in situ seldom becomes invasive cancer; however, having it in one breast increases the risk of developing breast cancer in either breast.
def-source: NCI-GLOSS

Axiom
annotated source: Lobular Breast Carcinoma In Situ
annotated property: has exact synonym
annotated target: LCIS
term-group: PT
term-source: NCI-GLOSS
source-code: CDR0000044433

Axiom
annotated source: Lobular Breast Carcinoma In Situ
annotated property: has exact synonym
annotated target: LCIS
term-group: SY
term-source: NCI

Axiom
annotated source: Lobular Breast Carcinoma In Situ
annotated property: has exact synonym
annotated target: Lobular Breast Carcinoma In Situ
term-group: PT
term-source: NCI

Axiom
annotated source: Lobular Breast Carcinoma In Situ
annotated property: has exact synonym
annotated target: Lobular Breast Carcinoma In Situ
term-group: SY
term-source: NCI
source-code: TCGA
subsource-name: caDSR

Axiom
annotated source: Lobular Breast Carcinoma In Situ
annotated property: has exact synonym
annotated target: Lobular Ca in situ of Breast
term-group: SY
term-source: NCI

Axiom
annotated source: Lobular Breast Carcinoma In Situ
annotated property: has exact synonym
annotated target: Lobular Ca in situ of the Breast
term-group: SY
term-source: NCI

Axiom
annotated source: Lobular Breast Carcinoma In Situ
annotated property: has exact synonym
annotated target: Lobular Carcinoma In Situ (LCIS)
term-group: DN
term-source: CTRP

Axiom
annotated source: Lobular Breast Carcinoma In Situ
annotated property: has exact synonym
annotated target: Lobular Carcinoma In Situ of the Breast
term-group: SY
term-source: NCI

Axiom
annotated source: Lobular Breast Carcinoma In Situ
annotated property: has exact synonym
annotated target: Lobular Carcinoma In Situ of the Breast (LCIS)
term-group: SY
term-source: NCI

Axiom
annotated source: Lobular Breast Carcinoma In Situ
annotated property: has exact synonym
annotated target: Lobular Carcinoma in situ
term-group: SY
term-source: NCI

Axiom
annotated source: Lobular Breast Carcinoma In Situ
annotated property: has exact synonym
annotated target: Lobular Carcinoma in situ of Breast
term-group: SY
term-source: NCI

Axiom
annotated source: Lobular Breast Carcinoma In Situ
annotated property: has exact synonym
annotated target: Lobular carcinoma in situ
term-group: PT
term-source: CTEP
source-code: 10024744
subsource-name: SDC

Axiom
annotated source: Lobular Breast Carcinoma In Situ
annotated property: has exact synonym
annotated target: Non-Infiltrating Lobular Breast Carcinoma
term-group: SY
term-source: NCI

Axiom
annotated source: Lobular Breast Carcinoma In Situ
annotated property: has exact synonym
annotated target: Non-Infiltrating Lobular Carcinoma
term-group: SY
term-source: NCI

Axiom
annotated source: Lobular Breast Carcinoma In Situ
annotated property: has exact synonym
annotated target: Non-Infiltrating Lobular Carcinoma of Breast
term-group: SY
term-source: NCI

Axiom
annotated source: Lobular Breast Carcinoma In Situ
annotated property: has exact synonym
annotated target: Non-Infiltrating Lobular Carcinoma of the Breast
term-group: SY
term-source: NCI

Axiom
annotated source: Lobular Breast Carcinoma In Situ
annotated property: has exact synonym
annotated target: Non-Invasive Lobular Breast Carcinoma
term-group: SY
term-source: NCI

Axiom
annotated source: Lobular Breast Carcinoma In Situ
annotated property: has exact synonym
annotated target: Non-Invasive Lobular Carcinoma of Breast
term-group: SY
term-source: NCI

Axiom
annotated source: Lobular Breast Carcinoma In Situ
annotated property: has exact synonym
annotated target: Non-Invasive Lobular Carcinoma of the Breast
term-group: SY
term-source: NCI

Axiom
annotated source: Lobular Breast Carcinoma In Situ
annotated property: has exact synonym
annotated target: lobular carcinoma in situ
term-group: PT
term-source: NCI-GLOSS
source-code: CDR0000046315

Uterine Corpus PEComa
type: Class
subclass of: PEComa
definition: A neoplasm with perivascular epithelioid cell differentiation arising from the uterine corpus wall.
code: C40180
Semantic_Type: Neoplastic Process
Preferred_Name: Uterine Corpus PEComa
UMLS_CUI: C1519862
Neoplastic_Status: Undetermined
Legacy_Concept_Name: Uterine_Corpus_Perivascular_Epithelioid_Cell_Tumor
has exact synonym: Uterine Corpus PEComa
has exact synonym: Uterine Corpus Perivascular Epithelioid Cell Tumor
in subset: oncotree slim

Axiom
annotated source: Uterine Corpus PEComa
annotated property: definition
annotated target: A neoplasm with perivascular epithelioid cell differentiation arising from the uterine corpus wall.
def-source: NCI

Axiom
annotated source: Uterine Corpus PEComa
annotated property: has exact synonym
annotated target: Uterine Corpus PEComa
term-group: PT
term-source: NCI

Axiom
annotated source: Uterine Corpus PEComa
annotated property: has exact synonym
annotated target: Uterine Corpus Perivascular Epithelioid Cell Tumor
term-group: SY
term-source: NCI

Fibroblastic Osteosarcoma
type: Class
definition: A conventional osteosarcoma characterized by the presence of spindle shaped cells.
Concept_In_Subset: NCIT C116977
Concept_In_Subset: NCIT C126659
code: C4020
Semantic_Type: Neoplastic Process
Display_Name: Fibroblastic Osteosarcoma
Preferred_Name: Fibroblastic Osteosarcoma
UMLS_CUI: C0279602
Contributing_Source: CTRP
ICD-O-3_Code: 9182/3
Neoplastic_Status: Malignant
Legacy_Concept_Name: Fibroblastic_Osteosarcoma
has exact synonym: Fibroblastic Osteogenic Sarcoma
has exact synonym: Fibroblastic Osteosarcoma
has exact synonym: Fibrosarcomatous Osteogenic Sarcoma
has exact synonym: Fibrosarcomatous Osteosarcoma
in subset: oncotree slim

Axiom
annotated source: Fibroblastic Osteosarcoma
annotated property: definition
annotated target: A conventional osteosarcoma characterized by the presence of spindle shaped cells.
def-source: NCI

Axiom
annotated source: Fibroblastic Osteosarcoma
annotated property: has exact synonym
annotated target: Fibroblastic Osteogenic Sarcoma
term-group: SY
term-source: NCI

Axiom
annotated source: Fibroblastic Osteosarcoma
annotated property: has exact synonym
annotated target: Fibroblastic Osteosarcoma
term-group: PT
term-source: NCI

Axiom
annotated source: Fibroblastic Osteosarcoma
annotated property: has exact synonym
annotated target: Fibrosarcomatous Osteogenic Sarcoma
term-group: SY
term-source: NCI

Axiom
annotated source: Fibroblastic Osteosarcoma
annotated property: has exact synonym
annotated target: Fibrosarcomatous Osteosarcoma
term-group: SY
term-source: NCI

Cervical Mucinous Adenocarcinoma, Intestinal-Type
type: Class
definition: A cervical mucinous adenocarcinoma that resembles the large intestinal adenocarcinoma.
code: C40203
Semantic_Type: Neoplastic Process
Preferred_Name: Cervical Mucinous Adenocarcinoma, Intestinal-Type
UMLS_CUI: C1516422
Neoplastic_Status: Malignant
Legacy_Concept_Name: Cervical_Mucinous_Adenocarcinoma_Intestinal_Variant
has exact synonym: Cervical Mucinous Adenocarcinoma, Intestinal Variant
has exact synonym: Cervical Mucinous Adenocarcinoma, Intestinal-Type
in subset: oncotree slim

Axiom
annotated source: Cervical Mucinous Adenocarcinoma, Intestinal-Type
annotated property: definition
annotated target: A cervical mucinous adenocarcinoma that resembles the large intestinal adenocarcinoma.
def-source: NCI

Axiom
annotated source: Cervical Mucinous Adenocarcinoma, Intestinal-Type
annotated property: has exact synonym
annotated target: Cervical Mucinous Adenocarcinoma, Intestinal Variant
term-group: SY
term-source: NCI

Axiom
annotated source: Cervical Mucinous Adenocarcinoma, Intestinal-Type
annotated property: has exact synonym
annotated target: Cervical Mucinous Adenocarcinoma, Intestinal-Type
term-group: PT
term-source: NCI

Cervical Mucinous Adenocarcinoma, Signet Ring Cell Type
type: Class
definition: A rare cervical mucinous adenocarcinoma characterized by the presence of signet ring cells.
code: C40205
Semantic_Type: Neoplastic Process
Preferred_Name: Cervical Mucinous Adenocarcinoma, Signet Ring Cell Type
UMLS_CUI: C1516424
Neoplastic_Status: Malignant
Legacy_Concept_Name: Cervical_Mucinous_Adenocarcinoma_Signet_Ring_Cell_Variant
has exact synonym: Cervical Mucinous Adenocarcinoma, Signet Ring Cell Type
has exact synonym: Cervical Mucinous Adenocarcinoma, Signet Ring Cell Variant
in subset: oncotree slim

Axiom
annotated source: Cervical Mucinous Adenocarcinoma, Signet Ring Cell Type
annotated property: definition
annotated target: A rare cervical mucinous adenocarcinoma characterized by the presence of signet ring cells.
def-source: NCI

Axiom
annotated source: Cervical Mucinous Adenocarcinoma, Signet Ring Cell Type
annotated property: has exact synonym
annotated target: Cervical Mucinous Adenocarcinoma, Signet Ring Cell Type
term-group: PT
term-source: NCI

Axiom
annotated source: Cervical Mucinous Adenocarcinoma, Signet Ring Cell Type
annotated property: has exact synonym
annotated target: Cervical Mucinous Adenocarcinoma, Signet Ring Cell Variant
term-group: SY
term-source: NCI

Cervical Villoglandular Adenocarcinoma
type: Class
subclass of: Cervical Adenocarcinoma
definition: A cervical adenocarcinoma characterized by the presence of a prominent villoglandular pattern.
code: C40208
Semantic_Type: Neoplastic Process
Preferred_Name: Cervical Villoglandular Adenocarcinoma
UMLS_CUI: C1516425
Neoplastic_Status: Malignant
Legacy_Concept_Name: Cervical_Mucinous_Adenocarcinoma_Villoglandular_Variant
has exact synonym: Cervical Adenocarcinoma, Villoglandular Variant
has exact synonym: Cervical Villoglandular Adenocarcinoma
has exact synonym: Cervical Villoglandular Carcinoma
in subset: oncotree slim

Axiom
annotated source: Cervical Villoglandular Adenocarcinoma
annotated property: definition
annotated target: A cervical adenocarcinoma characterized by the presence of a prominent villoglandular pattern.
def-source: NCI

Axiom
annotated source: Cervical Villoglandular Adenocarcinoma
annotated property: has exact synonym
annotated target: Cervical Adenocarcinoma, Villoglandular Variant
term-group: SY
term-source: NCI

Axiom
annotated source: Cervical Villoglandular Adenocarcinoma
annotated property: has exact synonym
annotated target: Cervical Villoglandular Adenocarcinoma
term-group: PT
term-source: NCI

Axiom
annotated source: Cervical Villoglandular Adenocarcinoma
annotated property: has exact synonym
annotated target: Cervical Villoglandular Carcinoma
term-group: SY
term-source: NCI

Cervical Adenosquamous Carcinoma, Glassy Cell Variant
type: Class
subclass of: Cervical Adenosquamous Carcinoma
definition: A poorly differentiated variant of adenosquamous carcinoma that arises from the cervix. It is characterized by the presence of large malignant cells with ground glass cytoplasm and stromal eosinophilic infiltrates.
code: C40212
Semantic_Type: Neoplastic Process
Preferred_Name: Cervical Adenosquamous Carcinoma, Glassy Cell Variant
UMLS_CUI: C1516407
Neoplastic_Status: Malignant
Legacy_Concept_Name: Cervical_Adenosquamous_Carcinoma_Glassy_Cell_Variant
has exact synonym: Cervical Adenosquamous Carcinoma, Glassy Cell Variant
in subset: oncotree slim

Axiom
annotated source: Cervical Adenosquamous Carcinoma, Glassy Cell Variant
annotated property: definition
annotated target: A poorly differentiated variant of adenosquamous carcinoma that arises from the cervix. It is characterized by the presence of large malignant cells with ground glass cytoplasm and stromal eosinophilic infiltrates.
def-source: NCI

Axiom
annotated source: Cervical Adenosquamous Carcinoma, Glassy Cell Variant
annotated property: has exact synonym
annotated target: Cervical Adenosquamous Carcinoma, Glassy Cell Variant
term-group: PT
term-source: NCI

Cervical Adenoid Basal Carcinoma
type: Class
definition: A rare low grade carcinoma that arises from the cervix. It is characterized by the presence of nests of basaloid cells with focal glandular formations.
code: C40213
Semantic_Type: Neoplastic Process
Preferred_Name: Cervical Adenoid Basal Carcinoma
UMLS_CUI: C1516403
Neoplastic_Status: Malignant
Legacy_Concept_Name: Cervical_Adenoid_Basal_Carcinoma
has exact synonym: Cervical Adenoid Basal Cancer
has exact synonym: Cervical Adenoid Basal Carcinoma
in subset: oncotree slim

Axiom
annotated source: Cervical Adenoid Basal Carcinoma
annotated property: definition
annotated target: A rare low grade carcinoma that arises from the cervix. It is characterized by the presence of nests of basaloid cells with focal glandular formations.
def-source: NCI

Axiom
annotated source: Cervical Adenoid Basal Carcinoma
annotated property: has exact synonym
annotated target: Cervical Adenoid Basal Cancer
term-group: DN
term-source: CTRP

Axiom
annotated source: Cervical Adenoid Basal Carcinoma
annotated property: has exact synonym
annotated target: Cervical Adenoid Basal Carcinoma
term-group: PT
term-source: NCI

Cervical Large Cell Neuroendocrine Carcinoma
type: Class
subclass of: Large Cell Neuroendocrine Carcinoma
definition: A rare, aggressive neuroendocrine carcinoma that arises from the cervix and is characterized by the presence of malignant cells with abundant cytoplasm, large nuclei, and prominent nucleoli.
code: C40214
Semantic_Type: Neoplastic Process
Preferred_Name: Cervical Large Cell Neuroendocrine Carcinoma
UMLS_CUI: C1516417
Neoplastic_Status: Malignant
Legacy_Concept_Name: Cervical_Large_Cell_Neuroendocrine_Carcinoma
has exact synonym: Cervical Large Cell Neuroendocrine Carcinoma
in subset: oncotree slim

Axiom
annotated source: Cervical Large Cell Neuroendocrine Carcinoma
annotated property: definition
annotated target: A rare, aggressive neuroendocrine carcinoma that arises from the cervix and is characterized by the presence of malignant cells with abundant cytoplasm, large nuclei, and prominent nucleoli.
def-source: NCI

Axiom
annotated source: Cervical Large Cell Neuroendocrine Carcinoma
annotated property: has exact synonym
annotated target: Cervical Large Cell Neuroendocrine Carcinoma
term-group: PT
term-source: NCI

Acral Lentiginous Melanoma
type: Class
subclass of: Cutaneous Melanoma
definition: A form of melanoma occurring most often on the plantar, palmar, subungual, and periungual skin. It presents as a pigmented macular lesion with irregular borders. Morphologically, it consists of atypical spindled and dendritic melanocytes. The epidermis is often hyperplastic and there is pagetoid infiltration of the epidermis by anaplastic cells.
Concept_In_Subset: NCIT C116977
code: C4022
Semantic_Type: Neoplastic Process
Display_Name: Acral Lentiginous Melanoma
Preferred_Name: Acral Lentiginous Melanoma
UMLS_CUI: C0346037
Contributing_Source: CTRP
ICD-O-3_Code: 8744/3
Neoplastic_Status: Malignant
Legacy_Concept_Name: Acral_Lentiginous_Malignant_Melanoma
has exact synonym: Acral Lentiginous Malignant Melanoma
has exact synonym: Acral Lentiginous Melanoma
in subset: oncotree slim

Axiom
annotated source: Acral Lentiginous Melanoma
annotated property: definition
annotated target: A form of melanoma occurring most often on the plantar, palmar, subungual, and periungual skin. It presents as a pigmented macular lesion with irregular borders. Morphologically, it consists of atypical spindled and dendritic melanocytes. The epidermis is often hyperplastic and there is pagetoid infiltration of the epidermis by anaplastic cells.
def-source: NCI

Axiom
annotated source: Acral Lentiginous Melanoma
annotated property: has exact synonym
annotated target: Acral Lentiginous Malignant Melanoma
term-group: SY
term-source: NCI

Axiom
annotated source: Acral Lentiginous Melanoma
annotated property: has exact synonym
annotated target: Acral Lentiginous Melanoma
term-group: DN
term-source: CTRP

Axiom
annotated source: Acral Lentiginous Melanoma
annotated property: has exact synonym
annotated target: Acral Lentiginous Melanoma
term-group: PT
term-source: NCI

Axiom
annotated source: Acral Lentiginous Melanoma
annotated property: has exact synonym
annotated target: Acral Lentiginous Melanoma
term-group: SY
term-source: NCI
source-code: TCGA
subsource-name: caDSR

Small Cell Osteosarcoma
type: Class
definition: An osteosarcoma usually arising from the metaphysis of long bones. It is characterized by the presence of small cells and osteoid production. The prognosis is usually unfavorable.
code: C4023
Semantic_Type: Neoplastic Process
Preferred_Name: Small Cell Osteosarcoma
UMLS_CUI: C0279622
ICD-O-3_Code: 9185/3
Neoplastic_Status: Malignant
Legacy_Concept_Name: Small_Cell_Osteosarcoma
has exact synonym: Small Cell Osteogenic Sarcoma
has exact synonym: Small Cell Osteosarcoma
in subset: oncotree slim

Axiom
annotated source: Small Cell Osteosarcoma
annotated property: definition
annotated target: An osteosarcoma usually arising from the metaphysis of long bones. It is characterized by the presence of small cells and osteoid production. The prognosis is usually unfavorable.
def-source: NCI

Axiom
annotated source: Small Cell Osteosarcoma
annotated property: has exact synonym
annotated target: Small Cell Osteogenic Sarcoma
term-group: SY
term-source: NCI

Axiom
annotated source: Small Cell Osteosarcoma
annotated property: has exact synonym
annotated target: Small Cell Osteosarcoma
term-group: PT
term-source: NCI

Esophageal Squamous Cell Carcinoma
type: Class
definition: A squamous cell carcinoma arising from the esophagus. It is associated with a long history of tobacco and alcohol abuse and is exceedingly rare before the age of 30. The median age is around 65 in both males and females. It is located mostly in the middle and lower third of the esophagus. Grossly, polypoid, ulcerated, plaque-like and occult lesions have been described. The microscopic features are the same as in other squamous cell carcinomas. Any degree of differentiation may occur, and variation within a single tumor is common. The prognosis is poor.
Concept_In_Subset: NCIT C102905
Concept_In_Subset: NCIT C103064
Concept_In_Subset: NCIT C116977
Concept_In_Subset: NCIT C126659
code: C4024
Semantic_Type: Neoplastic Process
Display_Name: Esophageal Squamous Cell Cancer
Preferred_Name: Esophageal Squamous Cell Carcinoma
UMLS_CUI: C0279626
Contributing_Source: CTEP
Contributing_Source: CTRP
Neoplastic_Status: Malignant
Legacy_Concept_Name: Esophageal_Squamous_Cell_Carcinoma
has exact synonym: ESCC
has exact synonym: Esophageal Epidermoid Carcinoma
has exact synonym: Esophageal SCC
has exact synonym: Esophageal Squamous Cell Cancer
has exact synonym: Esophageal Squamous Cell Carcinoma
has exact synonym: Esophagus SCC
has exact synonym: Esophagus Squamous Cell Carcinoma
has exact synonym: SCC of Esophagus
has exact synonym: SCC of the Esophagus
has exact synonym: Squamous Cell Carcinoma of Esophagus
has exact synonym: Squamous Cell Carcinoma of the Esophagus
has exact synonym: Squamous cell car. - esophagus
has exact synonym: Squamous cell carcinoma of the esophagus
in subset: oncotree slim

Axiom
annotated source: Esophageal Squamous Cell Carcinoma
annotated property: definition
annotated target: A squamous cell carcinoma arising from the esophagus. It is associated with a long history of tobacco and alcohol abuse and is exceedingly rare before the age of 30. The median age is around 65 in both males and females. It is located mostly in the middle and lower third of the esophagus. Grossly, polypoid, ulcerated, plaque-like and occult lesions have been described. The microscopic features are the same as in other squamous cell carcinomas. Any degree of differentiation may occur, and variation within a single tumor is common. The prognosis is poor.
def-source: NCI

Axiom
annotated source: Esophageal Squamous Cell Carcinoma
annotated property: has exact synonym
annotated target: ESCC
term-group: AB
term-source: NCI

Axiom
annotated source: Esophageal Squamous Cell Carcinoma
annotated property: has exact synonym
annotated target: Esophageal Epidermoid Carcinoma
term-group: SY
term-source: NCI

Axiom
annotated source: Esophageal Squamous Cell Carcinoma
annotated property: has exact synonym
annotated target: Esophageal SCC
term-group: SY
term-source: NCI

Axiom
annotated source: Esophageal Squamous Cell Carcinoma
annotated property: has exact synonym
annotated target: Esophageal Squamous Cell Cancer
term-group: DN
term-source: CTRP

Axiom
annotated source: Esophageal Squamous Cell Carcinoma
annotated property: has exact synonym
annotated target: Esophageal Squamous Cell Carcinoma
term-group: PT
term-source: NCI

Axiom
annotated source: Esophageal Squamous Cell Carcinoma
annotated property: has exact synonym
annotated target: Esophagus SCC
term-group: SY
term-source: NCI

Axiom
annotated source: Esophageal Squamous Cell Carcinoma
annotated property: has exact synonym
annotated target: Esophagus Squamous Cell Carcinoma
term-group: SY
term-source: NCI

Axiom
annotated source: Esophageal Squamous Cell Carcinoma
annotated property: has exact synonym
annotated target: SCC of Esophagus
term-group: SY
term-source: NCI

Axiom
annotated source: Esophageal Squamous Cell Carcinoma
annotated property: has exact synonym
annotated target: SCC of the Esophagus
term-group: SY
term-source: NCI

Axiom
annotated source: Esophageal Squamous Cell Carcinoma
annotated property: has exact synonym
annotated target: Squamous Cell Carcinoma of Esophagus
term-group: SY
term-source: NCI

Axiom
annotated source: Esophageal Squamous Cell Carcinoma
annotated property: has exact synonym
annotated target: Squamous Cell Carcinoma of the Esophagus
term-group: SY
term-source: NCI

Axiom
annotated source: Esophageal Squamous Cell Carcinoma
annotated property: has exact synonym
annotated target: Squamous cell car. - esophagus
term-group: SY
term-source: CTEP
source-code: 10030186
subsource-name: SDC

Axiom
annotated source: Esophageal Squamous Cell Carcinoma
annotated property: has exact synonym
annotated target: Squamous cell carcinoma of the esophagus
term-group: PT
term-source: CTEP
source-code: 10030186
subsource-name: SDC

Esophageal Adenocarcinoma
type: Class
definition: A malignant tumor with glandular differentiation arising predominantly from Barrett mucosa in the lower third of the esophagus. Rare examples of esophageal adenocarcinoma deriving from ectopic gastric mucosa in the upper esophagus have also been reported. Grossly, esophageal adenocarcinomas are similar to esophageal squamous cell carcinomas. Microscopically, adenocarcinomas arising in the setting of Barrett esophagus are typically papillary and/or tubular. The prognosis is poor.
Concept_In_Subset: NCIT C102905
Concept_In_Subset: NCIT C103064
Concept_In_Subset: NCIT C116977
Concept_In_Subset: NCIT C126659
code: C4025
Semantic_Type: Neoplastic Process
Display_Name: Esophageal Adenocarcinoma
Preferred_Name: Esophageal Adenocarcinoma
UMLS_CUI: C0279628
Contributing_Source: CTEP
Contributing_Source: CTRP
Neoplastic_Status: Malignant
Legacy_Concept_Name: Esophageal_Adenocarcinoma
has exact synonym: Adenocarcinoma - esophagus
has exact synonym: Adenocarcinoma of Esophagus
has exact synonym: Adenocarcinoma of the Esophagus
has exact synonym: Adenocarcinoma of the esophagus
has exact synonym: Esophageal Adenocarcinoma
has exact synonym: Esophagus Adenocarcinoma
has exact synonym: Oesophageal Adenocarcinoma NOS
in subset: oncotree slim

Axiom
annotated source: Esophageal Adenocarcinoma
annotated property: definition
annotated target: A malignant tumor with glandular differentiation arising predominantly from Barrett mucosa in the lower third of the esophagus. Rare examples of esophageal adenocarcinoma deriving from ectopic gastric mucosa in the upper esophagus have also been reported. Grossly, esophageal adenocarcinomas are similar to esophageal squamous cell carcinomas. Microscopically, adenocarcinomas arising in the setting of Barrett esophagus are typically papillary and/or tubular. The prognosis is poor.
def-source: NCI

Axiom
annotated source: Esophageal Adenocarcinoma
annotated property: has exact synonym
annotated target: Adenocarcinoma - esophagus
term-group: SY
term-source: CTEP
source-code: 10030139
subsource-name: SDC

Axiom
annotated source: Esophageal Adenocarcinoma
annotated property: has exact synonym
annotated target: Adenocarcinoma of Esophagus
term-group: SY
term-source: NCI

Axiom
annotated source: Esophageal Adenocarcinoma
annotated property: has exact synonym
annotated target: Adenocarcinoma of the Esophagus
term-group: SY
term-source: NCI

Axiom
annotated source: Esophageal Adenocarcinoma
annotated property: has exact synonym
annotated target: Adenocarcinoma of the esophagus
term-group: PT
term-source: CTEP
source-code: 10030139
subsource-name: SDC

Axiom
annotated source: Esophageal Adenocarcinoma
annotated property: has exact synonym
annotated target: Esophageal Adenocarcinoma
term-group: DN
term-source: CTRP

Axiom
annotated source: Esophageal Adenocarcinoma
annotated property: has exact synonym
annotated target: Esophageal Adenocarcinoma
term-group: PT
term-source: NCI

Axiom
annotated source: Esophageal Adenocarcinoma
annotated property: has exact synonym
annotated target: Esophagus Adenocarcinoma
term-group: SY
term-source: NCI

Axiom
annotated source: Esophageal Adenocarcinoma
annotated property: has exact synonym
annotated target: Oesophageal Adenocarcinoma NOS
term-group: SY
term-source: NCI

Vaginal Mucinous Adenocarcinoma
type: Class
subclass of: Mucinous Adenocarcinoma
definition: A rare adenocarcinoma that arises from the vagina with histologic features resembling cervical mucinous adenocarcinoma, endocervical type or cervical mucinous adenocarcinoma, intestinal variant.
code: C40252
Semantic_Type: Neoplastic Process
Preferred_Name: Vaginal Mucinous Adenocarcinoma
UMLS_CUI: C1519925
Neoplastic_Status: Malignant
Legacy_Concept_Name: Vaginal_Mucinous_Adenocarcinoma
has exact synonym: Vaginal Mucinous Adenocarcinoma
in subset: oncotree slim

Axiom
annotated source: Vaginal Mucinous Adenocarcinoma
annotated property: definition
annotated target: A rare adenocarcinoma that arises from the vagina with histologic features resembling cervical mucinous adenocarcinoma, endocervical type or cervical mucinous adenocarcinoma, intestinal variant.
def-source: NCI

Axiom
annotated source: Vaginal Mucinous Adenocarcinoma
annotated property: has exact synonym
annotated target: Vaginal Mucinous Adenocarcinoma
term-group: PT
term-source: NCI

Cervical Squamous Cell Carcinoma, Not Otherwise Specified
type: Class
definition: A squamous cell carcinoma arising from the cervical epithelium. It usually evolves from a precancerous cervical lesion. Increased numbers of sexual partners and human papillomavirus (HPV) infection are risk factors for cervical squamous cell carcinoma. The following histologic patterns have been described: conventional squamous cell carcinoma, papillary squamous cell carcinoma, transitional cell carcinoma, lymphoepithelioma-like carcinoma, verrucous carcinoma, condylomatous carcinoma and spindle cell carcinoma. Survival is most closely related to the stage of disease at the time of diagnosis.
Concept_In_Subset: NCIT C102905
Concept_In_Subset: NCIT C103098
Concept_In_Subset: NCIT C116977
Concept_In_Subset: NCIT C126659
code: C4028
Semantic_Type: Neoplastic Process
Display_Name: Cervical Squamous Cell Cancer
Preferred_Name: Cervical Squamous Cell Carcinoma, Not Otherwise Specified
UMLS_CUI: C0279671
Contributing_Source: CTEP
Contributing_Source: CTRP
Neoplastic_Status: Malignant
Legacy_Concept_Name: Cervical_Squamous_Cell_Carcinoma
has exact synonym: Cervical Squamous Cell Cancer
has exact synonym: Cervical Squamous Cell Carcinoma
has exact synonym: Cervical Squamous Cell Carcinoma, NOS
has exact synonym: Cervical Squamous Cell Carcinoma, Not Otherwise Specified
has exact synonym: Cervix Squamous Cell Carcinoma
has exact synonym: Cervix Uteri Squamous Cell Carcinoma
has exact synonym: Squamous Cell Carcinoma of Cervix
has exact synonym: Squamous Cell Carcinoma of Cervix Uteri
has exact synonym: Squamous Cell Carcinoma of Uterine Cervix
has exact synonym: Squamous Cell Carcinoma of the Cervix
has exact synonym: Squamous Cell Carcinoma of the Cervix Uteri
has exact synonym: Squamous Cell Carcinoma of the Uterine Cervix
has exact synonym: Squamous cervical cancer
has exact synonym: Uterine Cervix Squamous Cell Carcinoma
in subset: oncotree slim

Axiom
annotated source: Cervical Squamous Cell Carcinoma, Not Otherwise Specified
annotated property: definition
annotated target: A squamous cell carcinoma arising from the cervical epithelium. It usually evolves from a precancerous cervical lesion. Increased numbers of sexual partners and human papillomavirus (HPV) infection are risk factors for cervical squamous cell carcinoma. The following histologic patterns have been described: conventional squamous cell carcinoma, papillary squamous cell carcinoma, transitional cell carcinoma, lymphoepithelioma-like carcinoma, verrucous carcinoma, condylomatous carcinoma and spindle cell carcinoma. Survival is most closely related to the stage of disease at the time of diagnosis.
def-source: NCI

Axiom
annotated source: Cervical Squamous Cell Carcinoma, Not Otherwise Specified
annotated property: has exact synonym
annotated target: Cervical Squamous Cell Cancer
term-group: DN
term-source: CTRP

Axiom
annotated source: Cervical Squamous Cell Carcinoma, Not Otherwise Specified
annotated property: has exact synonym
annotated target: Cervical Squamous Cell Carcinoma
term-group: SY
term-source: NCI

Axiom
annotated source: Cervical Squamous Cell Carcinoma, Not Otherwise Specified
annotated property: has exact synonym
annotated target: Cervical Squamous Cell Carcinoma
term-group: SY
term-source: NCI
source-code: TCGA
subsource-name: caDSR

Axiom
annotated source: Cervical Squamous Cell Carcinoma, Not Otherwise Specified
annotated property: has exact synonym
annotated target: Cervical Squamous Cell Carcinoma, NOS
term-group: SY
term-source: NCI

Axiom
annotated source: Cervical Squamous Cell Carcinoma, Not Otherwise Specified
annotated property: has exact synonym
annotated target: Cervical Squamous Cell Carcinoma, Not Otherwise Specified
term-group: PT
term-source: NCI

Axiom
annotated source: Cervical Squamous Cell Carcinoma, Not Otherwise Specified
annotated property: has exact synonym
annotated target: Cervix Squamous Cell Carcinoma
term-group: SY
term-source: NCI

Axiom
annotated source: Cervical Squamous Cell Carcinoma, Not Otherwise Specified
annotated property: has exact synonym
annotated target: Cervix Uteri Squamous Cell Carcinoma
term-group: SY
term-source: NCI

Axiom
annotated source: Cervical Squamous Cell Carcinoma, Not Otherwise Specified
annotated property: has exact synonym
annotated target: Squamous Cell Carcinoma of Cervix
term-group: SY
term-source: NCI

Axiom
annotated source: Cervical Squamous Cell Carcinoma, Not Otherwise Specified
annotated property: has exact synonym
annotated target: Squamous Cell Carcinoma of Cervix Uteri
term-group: SY
term-source: NCI

Axiom
annotated source: Cervical Squamous Cell Carcinoma, Not Otherwise Specified
annotated property: has exact synonym
annotated target: Squamous Cell Carcinoma of Uterine Cervix
term-group: SY
term-source: NCI

Axiom
annotated source: Cervical Squamous Cell Carcinoma, Not Otherwise Specified
annotated property: has exact synonym
annotated target: Squamous Cell Carcinoma of the Cervix
term-group: SY
term-source: NCI

Axiom
annotated source: Cervical Squamous Cell Carcinoma, Not Otherwise Specified
annotated property: has exact synonym
annotated target: Squamous Cell Carcinoma of the Cervix Uteri
term-group: SY
term-source: NCI

Axiom
annotated source: Cervical Squamous Cell Carcinoma, Not Otherwise Specified
annotated property: has exact synonym
annotated target: Squamous Cell Carcinoma of the Uterine Cervix
term-group: SY
term-source: NCI

Axiom
annotated source: Cervical Squamous Cell Carcinoma, Not Otherwise Specified
annotated property: has exact synonym
annotated target: Squamous cervical cancer
term-group: PT
term-source: CTEP
source-code: 10041848
subsource-name: SDC

Axiom
annotated source: Cervical Squamous Cell Carcinoma, Not Otherwise Specified
annotated property: has exact synonym
annotated target: Uterine Cervix Squamous Cell Carcinoma
term-group: SY
term-source: NCI

Cervical Adenocarcinoma
type: Class
definition: An adenocarcinoma arising from the cervical epithelium. It accounts for approximately 15% of invasive cervical carcinomas. Increased numbers of sexual partners and human papillomavirus (HPV) infection are risk factors. Grossly, advanced cervical adenocarcinoma may present as an exophytic mass, an ulcerated lesion, or diffuse cervical enlargement. Microscopically, the majority of cervical adenocarcinomas are of the endocervical (mucinous) type.
Concept_In_Subset: NCIT C102905
Concept_In_Subset: NCIT C103098
Concept_In_Subset: NCIT C116977
Concept_In_Subset: NCIT C126659
code: C4029
Semantic_Type: Neoplastic Process
Display_Name: Cervical Adenocarcinoma
Preferred_Name: Cervical Adenocarcinoma
UMLS_CUI: C0279672
Contributing_Source: CTEP
Contributing_Source: CTRP
Neoplastic_Status: Malignant
Legacy_Concept_Name: Cervical_Adenocarcinoma
has exact synonym: Adenocarcinoma - cervix
has exact synonym: Adenocarcinoma of Cervix
has exact synonym: Adenocarcinoma of Cervix Uteri
has exact synonym: Adenocarcinoma of Uterine Cervix
has exact synonym: Adenocarcinoma of the Cervix
has exact synonym: Adenocarcinoma of the Cervix Uteri
has exact synonym: Adenocarcinoma of the Uterine Cervix
has exact synonym: Adenocarcinoma of the cervix
has exact synonym: Cervical Adenocarcinoma
has exact synonym: Cervical Adenocarcinoma, NOS
has exact synonym: Cervical Adenocarcinoma, Not Otherwise Specified
has exact synonym: Cervix Adenocarcinoma
has exact synonym: Cervix Uteri Adenocarcinoma
has exact synonym: Uterine Cervix Adenocarcinoma
in subset: oncotree slim

Axiom
annotated source: Cervical Adenocarcinoma
annotated property: definition
annotated target: An adenocarcinoma arising from the cervical epithelium. It accounts for approximately 15% of invasive cervical carcinomas. Increased numbers of sexual partners and human papillomavirus (HPV) infection are risk factors. Grossly, advanced cervical adenocarcinoma may present as an exophytic mass, an ulcerated lesion, or diffuse cervical enlargement. Microscopically, the majority of cervical adenocarcinomas are of the endocervical (mucinous) type.
def-source: NCI

Axiom
annotated source: Cervical Adenocarcinoma
annotated property: has exact synonym
annotated target: Adenocarcinoma - cervix
term-group: SY
term-source: CTEP
source-code: 10008224
subsource-name: SDC

Axiom
annotated source: Cervical Adenocarcinoma
annotated property: has exact synonym
annotated target: Adenocarcinoma of Cervix
term-group: SY
term-source: NCI

Axiom
annotated source: Cervical Adenocarcinoma
annotated property: has exact synonym
annotated target: Adenocarcinoma of Cervix Uteri
term-group: SY
term-source: NCI

Axiom
annotated source: Cervical Adenocarcinoma
annotated property: has exact synonym
annotated target: Adenocarcinoma of Uterine Cervix
term-group: SY
term-source: NCI

Axiom
annotated source: Cervical Adenocarcinoma
annotated property: has exact synonym
annotated target: Adenocarcinoma of the Cervix
term-group: SY
term-source: NCI

Axiom
annotated source: Cervical Adenocarcinoma
annotated property: has exact synonym
annotated target: Adenocarcinoma of the Cervix Uteri
term-group: SY
term-source: NCI

Axiom
annotated source: Cervical Adenocarcinoma
annotated property: has exact synonym
annotated target: Adenocarcinoma of the Uterine Cervix
term-group: SY
term-source: NCI

Axiom
annotated source: Cervical Adenocarcinoma
annotated property: has exact synonym
annotated target: Adenocarcinoma of the cervix
term-group: PT
term-source: CTEP
source-code: 10008224
subsource-name: SDC

Axiom
annotated source: Cervical Adenocarcinoma
annotated property: has exact synonym
annotated target: Cervical Adenocarcinoma
term-group: DN
term-source: CTRP

Axiom
annotated source: Cervical Adenocarcinoma
annotated property: has exact synonym
annotated target: Cervical Adenocarcinoma
term-group: PT
term-source: NCI

Axiom
annotated source: Cervical Adenocarcinoma
annotated property: has exact synonym
annotated target: Cervical Adenocarcinoma, NOS
term-group: SY
term-source: NCI

Axiom
annotated source: Cervical Adenocarcinoma
annotated property: has exact synonym
annotated target: Cervical Adenocarcinoma, Not Otherwise Specified
term-group: SY
term-source: NCI

Axiom
annotated source: Cervical Adenocarcinoma
annotated property: has exact synonym
annotated target: Cervix Adenocarcinoma
term-group: SY
term-source: NCI

Axiom
annotated source: Cervical Adenocarcinoma
annotated property: has exact synonym
annotated target: Cervix Uteri Adenocarcinoma
term-group: SY
term-source: NCI

Axiom
annotated source: Cervical Adenocarcinoma
annotated property: has exact synonym
annotated target: Uterine Cervix Adenocarcinoma
term-group: SY
term-source: NCI

Bladder Squamous Cell Carcinoma
type: Class
definition: A squamous cell carcinoma of the bladder arising from metaplastic epithelium. It represents less than 10% of bladder carcinomas. The exception is the Middle East along the Nile Valley, where it represents the most common form of carcinoma because of the endemic nature of schistosomiasis. Bladder squamous cell carcinoma is often associated with long-standing chronic inflammation of the bladder and usually has a poor prognosis. The diagnosis of squamous cell carcinoma of the bladder should be reserved for those tumors that are predominantly keratin forming.
Concept_In_Subset: NCIT C116977
Concept_In_Subset: NCIT C126659
code: C4031
Semantic_Type: Neoplastic Process
Display_Name: Bladder Squamous Cell Cancer
Preferred_Name: Bladder Squamous Cell Carcinoma
UMLS_CUI: C0279681
Contributing_Source: CTRP
Neoplastic_Status: Malignant
Legacy_Concept_Name: Bladder_Squamous_Cell_Carcinoma
has exact synonym: Bladder Epidermoid Carcinoma
has exact synonym: Bladder Squamous Cell Cancer
has exact synonym: Bladder Squamous Cell Carcinoma
has exact synonym: Epidermoid Carcinoma of Bladder
has exact synonym: Epidermoid Carcinoma of Urinary Bladder
has exact synonym: Epidermoid Carcinoma of the Bladder
has exact synonym: Epidermoid Carcinoma of the Urinary Bladder
has exact synonym: Squamous Cell Carcinoma of Bladder
has exact synonym: Squamous Cell Carcinoma of Urinary Bladder
has exact synonym: Squamous Cell Carcinoma of the Bladder
has exact synonym: Squamous Cell Carcinoma of the Urinary Bladder
has exact synonym: Urinary Bladder Epidermoid Carcinoma
has exact synonym: Urinary Bladder Squamous Cell Carcinoma
in subset: oncotree slim

Axiom
annotated source: Bladder Squamous Cell Carcinoma
annotated property: definition
annotated target: A squamous cell carcinoma of the bladder arising from metaplastic epithelium. It represents less than 10% of bladder carcinomas. The exception is the Middle East along the Nile Valley, where it represents the most common form of carcinoma because of the endemic nature of schistosomiasis. Bladder squamous cell carcinoma is often associated with long-standing chronic inflammation of the bladder and usually has a poor prognosis. The diagnosis of squamous cell carcinoma of the bladder should be reserved for those tumors that are predominantly keratin forming.
def-source: NCI

Axiom
annotated source: Bladder Squamous Cell Carcinoma
annotated property: has exact synonym
annotated target: Bladder Epidermoid Carcinoma
term-group: SY
term-source: NCI

Axiom
annotated source: Bladder Squamous Cell Carcinoma
annotated property: has exact synonym
annotated target: Bladder Squamous Cell Cancer
term-group: DN
term-source: CTRP

Axiom
annotated source: Bladder Squamous Cell Carcinoma
annotated property: has exact synonym
annotated target: Bladder Squamous Cell Carcinoma
term-group: PT
term-source: NCI

Axiom
annotated source: Bladder Squamous Cell Carcinoma
annotated property: has exact synonym
annotated target: Epidermoid Carcinoma of Bladder
term-group: SY
term-source: NCI

Axiom
annotated source: Bladder Squamous Cell Carcinoma
annotated property: has exact synonym
annotated target: Epidermoid Carcinoma of Urinary Bladder
term-group: SY
term-source: NCI

Axiom
annotated source: Bladder Squamous Cell Carcinoma
annotated property: has exact synonym
annotated target: Epidermoid Carcinoma of the Bladder
term-group: SY
term-source: NCI

Axiom
annotated source: Bladder Squamous Cell Carcinoma
annotated property: has exact synonym
annotated target: Epidermoid Carcinoma of the Urinary Bladder
term-group: SY
term-source: NCI

Axiom
annotated source: Bladder Squamous Cell Carcinoma
annotated property: has exact synonym
annotated target: Squamous Cell Carcinoma of Bladder
term-group: SY
term-source: NCI

Axiom
annotated source: Bladder Squamous Cell Carcinoma
annotated property: has exact synonym
annotated target: Squamous Cell Carcinoma of Urinary Bladder
term-group: SY
term-source: NCI

Axiom
annotated source: Bladder Squamous Cell Carcinoma
annotated property: has exact synonym
annotated target: Squamous Cell Carcinoma of the Bladder
term-group: SY
term-source: NCI

Axiom
annotated source: Bladder Squamous Cell Carcinoma
annotated property: has exact synonym
annotated target: Squamous Cell Carcinoma of the Urinary Bladder
term-group: SY
term-source: NCI

Axiom
annotated source: Bladder Squamous Cell Carcinoma
annotated property: has exact synonym
annotated target: Urinary Bladder Epidermoid Carcinoma
term-group: SY
term-source: NCI

Axiom
annotated source: Bladder Squamous Cell Carcinoma
annotated property: has exact synonym
annotated target: Urinary Bladder Squamous Cell Carcinoma
term-group: SY
term-source: NCI

Sebaceous Carcinoma
type: Class
subclass of: Adnexal Carcinoma
definition: An adenocarcinoma with sebaceous differentiation. It presents as a painless mass and it may be multifocal. It grows in the ocular adnexae and in the skin of head and neck, trunk, genitals, and extremities. It is characterized by the presence of malignant cells with multivesicular and clear cytoplasm. It may recur and metastasize.
Concept_In_Subset: NCIT C116977
Concept_In_Subset: NCIT C126659
Concept_In_Subset: NCIT C61410
Concept_In_Subset: NCIT C77526
Concept_In_Subset: NCIT C88025
code: C40310
Semantic_Type: Neoplastic Process
Display_Name: Sebaceous Cancer
Preferred_Name: Sebaceous Carcinoma
UMLS_CUI: C0206684
Contributing_Source: CDISC
Contributing_Source: CTRP
ALT_DEFINITION: An adenocarcinoma with sebaceous differentiation.
ICD-O-3_Code: 8410/3
Neoplastic_Status: Malignant
Legacy_Concept_Name: Sebaceous_Carcinoma
has exact synonym: ADENOCARCINOMA, SEBACEOUS, MALIGNANT
has exact synonym: Carcinoma of Sebaceous Gland
has exact synonym: Carcinoma of the Sebaceous Gland
has exact synonym: Sebaceous Carcinoma
has exact synonym: Sebaceous Gland Carcinoma
in subset: oncotree slim

Axiom
annotated source: Sebaceous Carcinoma
annotated property: definition
annotated target: An adenocarcinoma with sebaceous differentiation. It presents as a painless mass and it may be multifocal. It grows in the ocular adnexae and in the skin of head and neck, trunk, genitals, and extremities. It is characterized by the presence of malignant cells with multivesicular and clear cytoplasm. It may recur and metastasize.
def-source: NCI

Axiom
annotated source: Sebaceous Carcinoma
annotated property: ALT_DEFINITION
annotated target: An adenocarcinoma with sebaceous differentiation.
def-source: CDISC

Axiom
annotated source: Sebaceous Carcinoma
annotated property: has exact synonym
annotated target: ADENOCARCINOMA, SEBACEOUS, MALIGNANT
term-group: PT
term-source: CDISC

Axiom
annotated source: Sebaceous Carcinoma
annotated property: has exact synonym
annotated target: Carcinoma of Sebaceous Gland
term-group: SY
term-source: CDISC

Axiom
annotated source: Sebaceous Carcinoma
annotated property: has exact synonym
annotated target: Carcinoma of Sebaceous Gland
term-group: SY
term-source: NCI

Axiom
annotated source: Sebaceous Carcinoma
annotated property: has exact synonym
annotated target: Carcinoma of the Sebaceous Gland
term-group: SY
term-source: CDISC

Axiom
annotated source: Sebaceous Carcinoma
annotated property: has exact synonym
annotated target: Carcinoma of the Sebaceous Gland
term-group: SY
term-source: NCI

Axiom
annotated source: Sebaceous Carcinoma
annotated property: has exact synonym
annotated target: Sebaceous Carcinoma
term-group: PT
term-source: NCI

Axiom
annotated source: Sebaceous Carcinoma
annotated property: has exact synonym
annotated target: Sebaceous Gland Carcinoma
term-group: SY
term-source: CDISC

Axiom
annotated source: Sebaceous Carcinoma
annotated property: has exact synonym
annotated target: Sebaceous Gland Carcinoma
term-group: SY
term-source: NCI

Pilomyxoid Astrocytoma
type: Class
subclass of: Astrocytoma
definition: An astrocytic tumor of uncertain relation to pilocytic astrocytoma. It occurs predominantly in infants and young children. It is characterized by a monomorphic architectural pattern, usually associated with the absence of Rosenthal fibers and eosinophilic granular bodies. The clinical course is usually aggressive.
Concept_In_Subset: NCIT C126659
code: C40315
Semantic_Type: Neoplastic Process
Preferred_Name: Pilomyxoid Astrocytoma
UMLS_CUI: C1519086
ICD-O-3_Code: 9425/3
Neoplastic_Status: Undetermined
Legacy_Concept_Name: Pilomyxoid_Astrocytoma
has exact synonym: Pilomyxoid Astrocytoma
in subset: oncotree slim

Axiom
annotated source: Pilomyxoid Astrocytoma
annotated property: definition
annotated target: An astrocytic tumor of uncertain relation to pilocytic astrocytoma. It occurs predominantly in infants and young children. It is characterized by a monomorphic architectural pattern, usually associated with the absence of Rosenthal fibers and eosinophilic granular bodies. The clinical course is usually aggressive.
def-source: NCI

Axiom
annotated source: Pilomyxoid Astrocytoma
annotated property: has exact synonym
annotated target: Pilomyxoid Astrocytoma
term-group: PT
term-source: NCI

Bladder Adenocarcinoma
type: Class
definition: A rare adenocarcinoma arising from metaplastic bladder epithelium. It is frequently associated with long-standing local irritation. The majority of cases originate from the trigone and the posterior wall of the bladder.
Concept_In_Subset: NCIT C116977
Concept_In_Subset: NCIT C126659
code: C4032
Semantic_Type: Neoplastic Process
Display_Name: Bladder Adenocarcinoma
Preferred_Name: Bladder Adenocarcinoma
UMLS_CUI: C0279682
Contributing_Source: CTRP
Neoplastic_Status: Malignant
Legacy_Concept_Name: Bladder_Adenocarcinoma
has exact synonym: Adenocarcinoma of Bladder
has exact synonym: Adenocarcinoma of Urinary Bladder
has exact synonym: Adenocarcinoma of the Bladder
has exact synonym: Adenocarcinoma of the Urinary Bladder
has exact synonym: Bladder Adenocarcinoma
has exact synonym: Urinary Bladder Adenocarcinoma
in subset: oncotree slim

Axiom
annotated source: Bladder Adenocarcinoma
annotated property: definition
annotated target: A rare adenocarcinoma arising from metaplastic bladder epithelium. It is frequently associated with long-standing local irritation. The majority of cases originate from the trigone and the posterior wall of the bladder.
def-source: NCI

Axiom
annotated source: Bladder Adenocarcinoma
annotated property: has exact synonym
annotated target: Adenocarcinoma of Bladder
term-group: SY
term-source: NCI

Axiom
annotated source: Bladder Adenocarcinoma
annotated property: has exact synonym
annotated target: Adenocarcinoma of Urinary Bladder
term-group: SY
term-source: NCI

Axiom
annotated source: Bladder Adenocarcinoma
annotated property: has exact synonym
annotated target: Adenocarcinoma of the Bladder
term-group: SY
term-source: NCI

Axiom
annotated source: Bladder Adenocarcinoma
annotated property: has exact synonym
annotated target: Adenocarcinoma of the Urinary Bladder
term-group: SY
term-source: NCI

Axiom
annotated source: Bladder Adenocarcinoma
annotated property: has exact synonym
annotated target: Bladder Adenocarcinoma
term-group: DN
term-source: CTRP

Axiom
annotated source: Bladder Adenocarcinoma
annotated property: has exact synonym
annotated target: Bladder Adenocarcinoma
term-group: PT
term-source: NCI

Axiom
annotated source: Bladder Adenocarcinoma
annotated property: has exact synonym
annotated target: Urinary Bladder Adenocarcinoma
term-group: SY
term-source: NCI

Clear Cell Renal Cell Carcinoma
type: Class
subclass of: NCIT C9385
definition: A malignant epithelial neoplasm of the kidney characterized by the presence of lipid-containing clear cells within a vascular network. The tumor may metastasize to unusual sites and late metastasis is common.
Concept_In_Subset: NCIT C102905
Concept_In_Subset: NCIT C103084
Concept_In_Subset: NCIT C116977
Concept_In_Subset: NCIT C126659
code: C4033
Semantic_Type: Neoplastic Process
Display_Name: Clear Cell Renal Cell Cancer
Preferred_Name: Clear Cell Renal Cell Carcinoma
UMLS_CUI: C0279702
Contributing_Source: CTEP
Contributing_Source: CTRP
ALT_DEFINITION: The most common type of kidney cancer. It begins in the lining of the renal tubules in the kidney. The renal tubules filter the blood and produce urine.
Neoplastic_Status: Malignant
Legacy_Concept_Name: Conventional_Clear_Cell_Renal_Cell_Carcinoma
has exact synonym: Clear Cell Adenocarcinoma of Kidney
has exact synonym: Clear Cell Adenocarcinoma of the Kidney
has exact synonym: Clear Cell Adenocarcinoma, Kidney
has exact synonym: Clear Cell Carcinoma of Kidney
has exact synonym: Clear Cell Carcinoma of the Kidney
has exact synonym: Clear Cell Renal Cell Cancer
has exact synonym: Clear Cell Renal Cell Carcinoma
has exact synonym: Conventional (Clear Cell) Renal Cell Adenocarcinoma
has exact synonym: Conventional (Clear Cell) Renal Cell Carcinoma
has exact synonym: Conventional Renal Cell Carcinoma
has exact synonym: Grawitz Tumor
has exact synonym: Hypernephroma
has exact synonym: Kidney Clear Cell Adenocarcinoma
has exact synonym: Kidney Clear Cell Carcinoma
has exact synonym: RCC, clear cell adenocarcinoma
has exact synonym: Renal Clear Cell Adenocarcinoma
has exact synonym: Renal Clear Cell Carcinoma
has exact synonym: Renal cell carcinoma, clear cell adenocarcinoma
has exact synonym: hypernephroma
in subset: oncotree slim

Axiom
annotated source: Clear Cell Renal Cell Carcinoma
annotated property: definition
annotated target: A malignant epithelial neoplasm of the kidney characterized by the presence of lipid-containing clear cells within a vascular network. The tumor may metastasize to unusual sites and late metastasis is common.
def-source: NCI

Axiom
annotated source: Clear Cell Renal Cell Carcinoma
annotated property: ALT_DEFINITION
annotated target: The most common type of kidney cancer. It begins in the lining of the renal tubules in the kidney. The renal tubules filter the blood and produce urine.
def-source: NCI-GLOSS

Axiom
annotated source: Clear Cell Renal Cell Carcinoma
annotated property: has exact synonym
annotated target: Clear Cell Adenocarcinoma of Kidney
term-group: SY
term-source: NCI

Axiom
annotated source: Clear Cell Renal Cell Carcinoma
annotated property: has exact synonym
annotated target: Clear Cell Adenocarcinoma of the Kidney
term-group: SY
term-source: NCI

Axiom
annotated source: Clear Cell Renal Cell Carcinoma
annotated property: has exact synonym
annotated target: Clear Cell Adenocarcinoma, Kidney
term-group: SY
term-source: NCI

Axiom
annotated source: Clear Cell Renal Cell Carcinoma
annotated property: has exact synonym
annotated target: Clear Cell Carcinoma of Kidney
term-group: SY
term-source: NCI

Axiom
annotated source: Clear Cell Renal Cell Carcinoma
annotated property: has exact synonym
annotated target: Clear Cell Carcinoma of the Kidney
term-group: SY
term-source: NCI

Axiom
annotated source: Clear Cell Renal Cell Carcinoma
annotated property: has exact synonym
annotated target: Clear Cell Renal Cell Cancer
term-group: DN
term-source: CTRP

Axiom
annotated source: Clear Cell Renal Cell Carcinoma
annotated property: has exact synonym
annotated target: Clear Cell Renal Cell Carcinoma
term-group: PT
term-source: NCI

Axiom
annotated source: Clear Cell Renal Cell Carcinoma
annotated property: has exact synonym
annotated target: Clear Cell Renal Cell Carcinoma
term-group: SY
term-source: NCI
source-code: TCGA
subsource-name: caDSR

Axiom
annotated source: Clear Cell Renal Cell Carcinoma
annotated property: has exact synonym
annotated target: Conventional (Clear Cell) Renal Cell Adenocarcinoma
term-group: SY
term-source: NCI

Axiom
annotated source: Clear Cell Renal Cell Carcinoma
annotated property: has exact synonym
annotated target: Conventional (Clear Cell) Renal Cell Carcinoma
term-group: SY
term-source: NCI

Axiom
annotated source: Clear Cell Renal Cell Carcinoma
annotated property: has exact synonym
annotated target: Conventional Renal Cell Carcinoma
term-group: SY
term-source: NCI

Axiom
annotated source: Clear Cell Renal Cell Carcinoma
annotated property: has exact synonym
annotated target: Grawitz Tumor
term-group: AQS
term-source: NCI

Axiom
annotated source: Clear Cell Renal Cell Carcinoma
annotated property: has exact synonym
annotated target: Hypernephroma
term-group: AQS
term-source: NCI

Axiom
annotated source: Clear Cell Renal Cell Carcinoma
annotated property: has exact synonym
annotated target: Kidney Clear Cell Adenocarcinoma
term-group: SY
term-source: NCI

Axiom
annotated source: Clear Cell Renal Cell Carcinoma
annotated property: has exact synonym
annotated target: Kidney Clear Cell Carcinoma
term-group: SY
term-source: NCI

Axiom
annotated source: Clear Cell Renal Cell Carcinoma
annotated property: has exact synonym
annotated target: RCC, clear cell adenocarcinoma
term-group: SY
term-source: CTEP
source-code: 10009251
subsource-name: SDC

Axiom
annotated source: Clear Cell Renal Cell Carcinoma
annotated property: has exact synonym
annotated target: Renal Clear Cell Adenocarcinoma
term-group: SY
term-source: NCI

Axiom
annotated source: Clear Cell Renal Cell Carcinoma
annotated property: has exact synonym
annotated target: Renal Clear Cell Carcinoma
term-group: SY
term-source: NCI

Axiom
annotated source: Clear Cell Renal Cell Carcinoma
annotated property: has exact synonym
annotated target: Renal cell carcinoma, clear cell adenocarcinoma
term-group: PT
term-source: CTEP
source-code: 10009251
subsource-name: SDC

Axiom
annotated source: Clear Cell Renal Cell Carcinoma
annotated property: has exact synonym
annotated target: hypernephroma
term-group: PT
term-source: NCI-GLOSS
source-code: CDR0000344350

Thyroid Gland Papillary Carcinoma
type: Class
definition: A differentiated adenocarcinoma arising from the follicular cells of the thyroid gland. Radiation exposure is a risk factor and it is the most common malignant thyroid lesion, comprising 75% to 80% of all thyroid cancers in iodine sufficient countries. Diagnostic procedures include thyroid ultrasound and fine needle biopsy. Microscopically, the diagnosis is based on the distinct characteristics of the malignant cells, which include enlargement, oval shape, elongation, and overlapping of the nuclei. The nuclei also display clearing or have a ground glass appearance.
Has_NICHD_Parent: NCIT C3414
Concept_In_Subset: NCIT C102905
Concept_In_Subset: NCIT C103059
Concept_In_Subset: NCIT C116977
Concept_In_Subset: NCIT C118467
Concept_In_Subset: NCIT C126659
Concept_In_Subset: NCIT C90259
code: C4035
Semantic_Type: Neoplastic Process
Display_Name: Thyroid Gland Papillary Cancer
Preferred_Name: Thyroid Gland Papillary Carcinoma
UMLS_CUI: C0238463
Contributing_Source: CTEP
Contributing_Source: CTRP
Contributing_Source: NICHD
ALT_DEFINITION: A differentiated adenocarcinoma arising from the follicular cells of the thyroid gland. The diagnosis is based on the distinct characteristics of the malignant cells, which include enlargement, oval shape, elongation, and overlapping of the nuclei. The nuclei also display clearing or have a ground glass appearance.
ALT_DEFINITION: Cancer that forms in follicular cells in the thyroid and grows in small finger-like shapes. It grows slowly, is more common in women than in men, and often occurs before age 45. It is the most common type of thyroid cancer.
Neoplastic_Status: Malignant
Legacy_Concept_Name: Papillary_Thyroid_Carcinoma
NICHD_Hierarchy_Term: Papillary Thyroid Carcinoma
has exact synonym: Papillary Cancer of Thyroid
has exact synonym: Papillary Cancer of Thyroid Gland
has exact synonym: Papillary Cancer of the Thyroid
has exact synonym: Papillary Cancer of the Thyroid Gland
has exact synonym: Papillary Carcinoma of Thyroid
has exact synonym: Papillary Carcinoma of Thyroid Gland
has exact synonym: Papillary Carcinoma of the Thyroid
has exact synonym: Papillary Carcinoma of the Thyroid Gland
has exact synonym: Papillary Thyroid Cancer
has exact synonym: Papillary Thyroid Carcinoma
has exact synonym: Papillary Thyroid Gland Carcinoma
has exact synonym: Papillary thyroid carcinoma
has exact synonym: Thyroid Gland Papillary Cancer
has exact synonym: Thyroid Gland Papillary Carcinoma
has exact synonym: Thyroid Papillary Carcinoma
has exact synonym: papillary thyroid cancer
in subset: oncotree slim

Axiom
annotated source: Thyroid Gland Papillary Carcinoma
annotated property: definition
annotated target: A differentiated adenocarcinoma arising from the follicular cells of the thyroid gland. Radiation exposure is a risk factor and it is the most common malignant thyroid lesion, comprising 75% to 80% of all thyroid cancers in iodine sufficient countries. Diagnostic procedures include thyroid ultrasound and fine needle biopsy. Microscopically, the diagnosis is based on the distinct characteristics of the malignant cells, which include enlargement, oval shape, elongation, and overlapping of the nuclei. The nuclei also display clearing or have a ground glass appearance.
def-source: NCI

Axiom
annotated source: Thyroid Gland Papillary Carcinoma
annotated property: ALT_DEFINITION
annotated target: A differentiated adenocarcinoma arising from the follicular cells of the thyroid gland. The diagnosis is based on the distinct characteristics of the malignant cells, which include enlargement, oval shape, elongation, and overlapping of the nuclei. The nuclei also display clearing or have a ground glass appearance.
def-source: NICHD

Axiom
annotated source: Thyroid Gland Papillary Carcinoma
annotated property: ALT_DEFINITION
annotated target: Cancer that forms in follicular cells in the thyroid and grows in small finger-like shapes. It grows slowly, is more common in women than in men, and often occurs before age 45. It is the most common type of thyroid cancer.
def-source: NCI-GLOSS

Axiom
annotated source: Thyroid Gland Papillary Carcinoma
annotated property: has exact synonym
annotated target: Papillary Cancer of Thyroid
term-group: SY
term-source: NCI

Axiom
annotated source: Thyroid Gland Papillary Carcinoma
annotated property: has exact synonym
annotated target: Papillary Cancer of Thyroid Gland
term-group: SY
term-source: NCI

Axiom
annotated source: Thyroid Gland Papillary Carcinoma
annotated property: has exact synonym
annotated target: Papillary Cancer of the Thyroid
term-group: SY
term-source: NCI

Axiom
annotated source: Thyroid Gland Papillary Carcinoma
annotated property: has exact synonym
annotated target: Papillary Cancer of the Thyroid Gland
term-group: SY
term-source: NCI

Axiom
annotated source: Thyroid Gland Papillary Carcinoma
annotated property: has exact synonym
annotated target: Papillary Carcinoma of Thyroid
term-group: SY
term-source: NCI

Axiom
annotated source: Thyroid Gland Papillary Carcinoma
annotated property: has exact synonym
annotated target: Papillary Carcinoma of Thyroid Gland
term-group: SY
term-source: NCI

Axiom
annotated source: Thyroid Gland Papillary Carcinoma
annotated property: has exact synonym
annotated target: Papillary Carcinoma of the Thyroid
term-group: SY
term-source: NCI

Axiom
annotated source: Thyroid Gland Papillary Carcinoma
annotated property: has exact synonym
annotated target: Papillary Carcinoma of the Thyroid Gland
term-group: SY
term-source: NCI

Axiom
annotated source: Thyroid Gland Papillary Carcinoma
annotated property: has exact synonym
annotated target: Papillary Thyroid Cancer
term-group: SY
term-source: NCI

Axiom
annotated source: Thyroid Gland Papillary Carcinoma
annotated property: has exact synonym
annotated target: Papillary Thyroid Carcinoma
term-group: PT
term-source: NICHD

Axiom
annotated source: Thyroid Gland Papillary Carcinoma
annotated property: has exact synonym
annotated target: Papillary Thyroid Carcinoma
term-group: SY
term-source: NCI

Axiom
annotated source: Thyroid Gland Papillary Carcinoma
annotated property: has exact synonym
annotated target: Papillary Thyroid Gland Carcinoma
term-group: SY
term-source: NCI

Axiom
annotated source: Thyroid Gland Papillary Carcinoma
annotated property: has exact synonym
annotated target: Papillary thyroid carcinoma
term-group: PT
term-source: CTEP
source-code: 10033701
subsource-name: SDC

Axiom
annotated source: Thyroid Gland Papillary Carcinoma
annotated property: has exact synonym
annotated target: Thyroid Gland Papillary Cancer
term-group: DN
term-source: CTRP

Axiom
annotated source: Thyroid Gland Papillary Carcinoma
annotated property: has exact synonym
annotated target: Thyroid Gland Papillary Carcinoma
term-group: PT
term-source: NCI

Axiom
annotated source: Thyroid Gland Papillary Carcinoma
annotated property: has exact synonym
annotated target: Thyroid Gland Papillary Carcinoma
term-group: SY
term-source: NCI
source-code: TCGA
subsource-name: caDSR

Axiom
annotated source: Thyroid Gland Papillary Carcinoma
annotated property: has exact synonym
annotated target: Thyroid Papillary Carcinoma
term-group: SY
term-source: NCI

Axiom
annotated source: Thyroid Gland Papillary Carcinoma
annotated property: has exact synonym
annotated target: papillary thyroid cancer
term-group: PT
term-source: NCI-GLOSS
source-code: CDR0000044553

Squamous Cell Breast Carcinoma, Spindle Cell Variant
type: Class
subclass of: Squamous Cell Breast Carcinoma
definition: A squamous cell carcinoma that arises from the breast parenchyma and is characterized by the presence of spindle-shaped malignant cells.
code: C40358
Semantic_Type: Neoplastic Process
Preferred_Name: Squamous Cell Breast Carcinoma, Spindle Cell Variant
UMLS_CUI: C1519487
Neoplastic_Status: Malignant
Legacy_Concept_Name: Squamous_Cell_Breast_Carcinoma_Spindle_Cell_Variant
has exact synonym: Squamous Cell Breast Carcinoma, Spindle Cell Variant
in subset: oncotree slim

Axiom
annotated source: Squamous Cell Breast Carcinoma, Spindle Cell Variant
annotated property: definition
annotated target: A squamous cell carcinoma that arises from the breast parenchyma and is characterized by the presence of spindle-shaped malignant cells.
def-source: NCI

Axiom
annotated source: Squamous Cell Breast Carcinoma, Spindle Cell Variant
annotated property: has exact synonym
annotated target: Squamous Cell Breast Carcinoma, Spindle Cell Variant
term-group: PT
term-source: NCI

Adenosquamous Breast Carcinoma
type: Class
subclass of: NCIT C9245
definition: An invasive breast carcinoma characterized by the presence of tubular and glandular neoplastic cell structures, admixed with islands of neoplastic cells showing squamous differentiation.
code: C40361
Semantic_Type: Neoplastic Process
Preferred_Name: Adenosquamous Breast Carcinoma
UMLS_CUI: C1510796
Neoplastic_Status: Malignant
Legacy_Concept_Name: Adenosquamous_Breast_Carcinoma
has exact synonym: Adenosquamous Breast Carcinoma
in subset: oncotree slim

Axiom
annotated source: Adenosquamous Breast Carcinoma
annotated property: definition
annotated target: An invasive breast carcinoma characterized by the presence of tubular and glandular neoplastic cell structures, admixed with islands of neoplastic cells showing squamous differentiation.
def-source: NCI

Axiom
annotated source: Adenosquamous Breast Carcinoma
annotated property: has exact synonym
annotated target: Adenosquamous Breast Carcinoma
term-group: PT
term-source: NCI

Mixed Epithelial/Mesenchymal Metaplastic Breast Carcinoma
type: Class
subclass of: Metaplastic Breast Carcinoma
definition: An invasive breast carcinoma characterized by the presence of a mesenchymal cellular component. The mesenchymal cellular component ranges from cartilaginous and osseous, to purely sarcomatous.
code: C40364
Semantic_Type: Neoplastic Process
Preferred_Name: Mixed Epithelial/Mesenchymal Metaplastic Breast Carcinoma
UMLS_CUI: C1513365
Neoplastic_Status: Malignant
Legacy_Concept_Name: Mixed_Epithelial_Mesenchymal_Metaplastic_Breast_Carcinoma
has exact synonym: Breast Carcinosarcoma
has exact synonym: Mixed Epithelial/Mesenchymal Metaplastic Breast Carcinoma
in subset: oncotree slim

Axiom
annotated source: Mixed Epithelial/Mesenchymal Metaplastic Breast Carcinoma
annotated property: definition
annotated target: An invasive breast carcinoma characterized by the presence of a mesenchymal cellular component. The mesenchymal cellular component ranges from cartilaginous and osseous, to purely sarcomatous.
def-source: NCI

Axiom
annotated source: Mixed Epithelial/Mesenchymal Metaplastic Breast Carcinoma
annotated property: has exact synonym
annotated target: Breast Carcinosarcoma
term-group: SY
term-source: NCI

Axiom
annotated source: Mixed Epithelial/Mesenchymal Metaplastic Breast Carcinoma
annotated property: has exact synonym
annotated target: Mixed Epithelial/Mesenchymal Metaplastic Breast Carcinoma
term-group: PT
term-source: NCI

Lung Carcinoid Tumor
type: Class
definition: A neuroendocrine neoplasm that arises from the lung. It is characterized by the presence of uniform polygonal cells with small or moderate amount of cytoplasm and inconspicuous nucleoli. The cells are usually arranged in organoid and trabecular patterns. It is classified as typical or atypical carcinoid tumor based on the number of mitotic figures and the absence or presence of necrosis. Atypical carcinoid tumors have a worse prognosis.
Concept_In_Subset: NCIT C116977
code: C4038
Semantic_Type: Neoplastic Process
Display_Name: Lung Carcinoid Tumor
Preferred_Name: Lung Carcinoid Tumor
UMLS_CUI: C0280089
Contributing_Source: CTRP
Neoplastic_Status: Undetermined
Legacy_Concept_Name: Lung_Carcinoid_Tumor
has exact synonym: Carcinoid Tumor of Lung
has exact synonym: Carcinoid Tumor of the Lung
has exact synonym: Lung Carcinoid Tumor
has exact synonym: Pulmonary Carcinoid Tumor
in subset: oncotree slim

Axiom
annotated source: Lung Carcinoid Tumor
annotated property: definition
annotated target: A neuroendocrine neoplasm that arises from the lung. It is characterized by the presence of uniform polygonal cells with small or moderate amount of cytoplasm and inconspicuous nucleoli. The cells are usually arranged in organoid and trabecular patterns. It is classified as typical or atypical carcinoid tumor based on the number of mitotic figures and the absence or presence of necrosis. Atypical carcinoid tumors have a worse prognosis.
def-source: NCI

Axiom
annotated source: Lung Carcinoid Tumor
annotated property: has exact synonym
annotated target: Carcinoid Tumor of Lung
term-group: SY
term-source: NCI

Axiom
annotated source: Lung Carcinoid Tumor
annotated property: has exact synonym
annotated target: Carcinoid Tumor of the Lung
term-group: SY
term-source: NCI

Axiom
annotated source: Lung Carcinoid Tumor
annotated property: has exact synonym
annotated target: Lung Carcinoid Tumor
term-group: PT
term-source: NCI

Axiom
annotated source: Lung Carcinoid Tumor
annotated property: has exact synonym
annotated target: Pulmonary Carcinoid Tumor
term-group: SY
term-source: NCI

Hypopharyngeal Squamous Cell Carcinoma
type: Class
definition: A squamous cell carcinoma arising from the hypopharynx. Signs and symptoms include dysphagia, hemoptysis, and the presence of a neck mass.
Concept_In_Subset: NCIT C116977
Concept_In_Subset: NCIT C126659
code: C4043
Semantic_Type: Neoplastic Process
Display_Name: Hypopharyngeal Squamous Cell Cancer
Preferred_Name: Hypopharyngeal Squamous Cell Carcinoma
UMLS_CUI: C0280321
Contributing_Source: CTRP
Neoplastic_Status: Malignant
Legacy_Concept_Name: Hypopharyngeal_Squamous_Cell_Carcinoma
has exact synonym: Epidermoid Carcinoma of Hypopharynx
has exact synonym: Epidermoid Carcinoma of the Hypopharynx
has exact synonym: Hypopharyngeal Epidermoid Carcinoma
has exact synonym: Hypopharyngeal Squamous Cell Carcinoma
has exact synonym: Hypopharyngeal Throat Squamous Cell Cancer
has exact synonym: Squamous Cell Carcinoma of Hypopharynx
has exact synonym: Squamous Cell Carcinoma of the Hypopharynx
in subset: oncotree slim

Axiom
annotated source: Hypopharyngeal Squamous Cell Carcinoma
annotated property: definition
annotated target: A squamous cell carcinoma arising from the hypopharynx. Signs and symptoms include dysphagia, hemoptysis, and the presence of a neck mass.
def-source: NCI

Axiom
annotated source: Hypopharyngeal Squamous Cell Carcinoma
annotated property: has exact synonym
annotated target: Epidermoid Carcinoma of Hypopharynx
term-group: SY
term-source: NCI

Axiom
annotated source: Hypopharyngeal Squamous Cell Carcinoma
annotated property: has exact synonym
annotated target: Epidermoid Carcinoma of the Hypopharynx
term-group: SY
term-source: NCI

Axiom
annotated source: Hypopharyngeal Squamous Cell Carcinoma
annotated property: has exact synonym
annotated target: Hypopharyngeal Epidermoid Carcinoma
term-group: SY
term-source: NCI

Axiom
annotated source: Hypopharyngeal Squamous Cell Carcinoma
annotated property: has exact synonym
annotated target: Hypopharyngeal Squamous Cell Carcinoma
term-group: PT
term-source: NCI

Axiom
annotated source: Hypopharyngeal Squamous Cell Carcinoma
annotated property: has exact synonym
annotated target: Hypopharyngeal Throat Squamous Cell Cancer
term-group: DN
term-source: CTRP

Axiom
annotated source: Hypopharyngeal Squamous Cell Carcinoma
annotated property: has exact synonym
annotated target: Squamous Cell Carcinoma of Hypopharynx
term-group: SY
term-source: NCI

Axiom
annotated source: Hypopharyngeal Squamous Cell Carcinoma
annotated property: has exact synonym
annotated target: Squamous Cell Carcinoma of the Hypopharynx
term-group: SY
term-source: NCI

Laryngeal Squamous Cell Carcinoma
type: Class
subclass of: Head and Neck Squamous Cell Carcinoma
definition: A squamous cell carcinoma that arises from the larynx. It is the most common histologic type of laryngeal carcinoma. It can arise from the glottis, supraglottic area, or it can be transglottic. Glottic squamous cell carcinoma is the most frequent laryngeal carcinoma in the United States. The symptoms, clinical behavior and the prognosis depend on the site of origin within the larynx.
Concept_In_Subset: NCIT C102905
Concept_In_Subset: NCIT C103075
Concept_In_Subset: NCIT C116977
Concept_In_Subset: NCIT C126659
code: C4044
Semantic_Type: Neoplastic Process
Display_Name: Laryngeal Squamous Cell Cancer
Preferred_Name: Laryngeal Squamous Cell Carcinoma
UMLS_CUI: C0280324
Contributing_Source: CTEP
Contributing_Source: CTRP
Neoplastic_Status: Malignant
Legacy_Concept_Name: Laryngeal_Squamous_Cell_Carcinoma
has exact synonym: Epidermoid Carcinoma of Larynx
has exact synonym: Epidermoid Carcinoma of the Larynx
has exact synonym: Laryngeal Epidermoid Carcinoma
has exact synonym: Laryngeal Squamous Cell Carcinoma
has exact synonym: Laryngeal Throat Squamous Cell Cancer
has exact synonym: Laryngeal squamous cell carcinoma
has exact synonym: Larynx Epidermoid Carcinoma
has exact synonym: Larynx Squamous Cell Carcinoma
has exact synonym: Squamous Cell Carcinoma of Larynx
has exact synonym: Squamous Cell Carcinoma of the Larynx
in subset: oncotree slim

Axiom
annotated source: Laryngeal Squamous Cell Carcinoma
annotated property: definition
annotated target: A squamous cell carcinoma that arises from the larynx. It is the most common histologic type of laryngeal carcinoma. It can arise from the glottis, supraglottic area, or it can be transglottic. Glottic squamous cell carcinoma is the most frequent laryngeal carcinoma in the United States. The symptoms, clinical behavior and the prognosis depend on the site of origin within the larynx.
def-source: NCI

Axiom
annotated source: Laryngeal Squamous Cell Carcinoma
annotated property: has exact synonym
annotated target: Epidermoid Carcinoma of Larynx
term-group: SY
term-source: NCI

Axiom
annotated source: Laryngeal Squamous Cell Carcinoma
annotated property: has exact synonym
annotated target: Epidermoid Carcinoma of the Larynx
term-group: SY
term-source: NCI

Axiom
annotated source: Laryngeal Squamous Cell Carcinoma
annotated property: has exact synonym
annotated target: Laryngeal Epidermoid Carcinoma
term-group: SY
term-source: NCI

Axiom
annotated source: Laryngeal Squamous Cell Carcinoma
annotated property: has exact synonym
annotated target: Laryngeal Squamous Cell Carcinoma
term-group: PT
term-source: NCI

Axiom
annotated source: Laryngeal Squamous Cell Carcinoma
annotated property: has exact synonym
annotated target: Laryngeal Throat Squamous Cell Cancer
term-group: DN
term-source: CTRP

Axiom
annotated source: Laryngeal Squamous Cell Carcinoma
annotated property: has exact synonym
annotated target: Laryngeal squamous cell carcinoma
term-group: PT
term-source: CTEP
source-code: 10023843
subsource-name: SDC

Axiom
annotated source: Laryngeal Squamous Cell Carcinoma
annotated property: has exact synonym
annotated target: Larynx Epidermoid Carcinoma
term-group: SY
term-source: NCI

Axiom
annotated source: Laryngeal Squamous Cell Carcinoma
annotated property: has exact synonym
annotated target: Larynx Squamous Cell Carcinoma
term-group: SY
term-source: NCI

Axiom
annotated source: Laryngeal Squamous Cell Carcinoma
annotated property: has exact synonym
annotated target: Squamous Cell Carcinoma of Larynx
term-group: SY
term-source: NCI

Axiom
annotated source: Laryngeal Squamous Cell Carcinoma
annotated property: has exact synonym
annotated target: Squamous Cell Carcinoma of the Larynx
term-group: SY
term-source: NCI

Pilocytic Astrocytoma
type: Class
subclass of: Astrocytoma
definition: A WHO grade I, relatively circumscribed, slowly growing, often cystic astrocytoma occurring in children and young adults. Histologically it is characterized by a biphasic pattern with compacted bipolar cells associated with Rosenthal fibers and multipolar cells associated with microcysts and eosinophilic bodies/hyaline droplets. (WHO)
Concept_In_Subset: NCIT C102905
Concept_In_Subset: NCIT C103043
Concept_In_Subset: NCIT C126659
Concept_In_Subset: NCIT C61410
Concept_In_Subset: NCIT C77526
Concept_In_Subset: NCIT C88025
code: C4047
Semantic_Type: Neoplastic Process
Preferred_Name: Pilocytic Astrocytoma
UMLS_CUI: C0334583
Contributing_Source: CDISC
Contributing_Source: CTEP
ALT_DEFINITION: A benign neoplasm of the brain or spinal cord arising from astrocytes associated with single or multiple cysts.
ICD-O-3_Code: 9421/1
Neoplastic_Status: Undetermined
Legacy_Concept_Name: Pilocytic_Astrocytoma
has exact synonym: ASTROCYTOMA, PILOCYTIC, BENIGN
has exact synonym: Astrocytoma, Benign
has exact synonym: Grade I Astrocytic Neoplasm
has exact synonym: Grade I Astrocytic Tumor
has exact synonym: Grade I Astrocytoma
has exact synonym: Pilocytic Astrocytoma
has exact synonym: Pilocytic astrocytoma
in subset: oncotree slim

Axiom
annotated source: Pilocytic Astrocytoma
annotated property: definition
annotated target: A WHO grade I, relatively circumscribed, slowly growing, often cystic astrocytoma occurring in children and young adults. Histologically it is characterized by a biphasic pattern with compacted bipolar cells associated with Rosenthal fibers and multipolar cells associated with microcysts and eosinophilic bodies/hyaline droplets. (WHO)
def-source: NCI

Axiom
annotated source: Pilocytic Astrocytoma
annotated property: ALT_DEFINITION
annotated target: A benign neoplasm of the brain or spinal cord arising from astrocytes associated with single or multiple cysts.
def-source: CDISC

Axiom
annotated source: Pilocytic Astrocytoma
annotated property: has exact synonym
annotated target: ASTROCYTOMA, PILOCYTIC, BENIGN
term-group: PT
term-source: CDISC

Axiom
annotated source: Pilocytic Astrocytoma
annotated property: has exact synonym
annotated target: Astrocytoma, Benign
term-group: SY
term-source: CDISC

Axiom
annotated source: Pilocytic Astrocytoma
annotated property: has exact synonym
annotated target: Grade I Astrocytic Neoplasm
term-group: SY
term-source: CDISC

Axiom
annotated source: Pilocytic Astrocytoma
annotated property: has exact synonym
annotated target: Grade I Astrocytic Neoplasm
term-group: SY
term-source: NCI

Axiom
annotated source: Pilocytic Astrocytoma
annotated property: has exact synonym
annotated target: Grade I Astrocytic Tumor
term-group: SY
term-source: CDISC

Axiom
annotated source: Pilocytic Astrocytoma
annotated property: has exact synonym
annotated target: Grade I Astrocytic Tumor
term-group: SY
term-source: NCI

Axiom
annotated source: Pilocytic Astrocytoma
annotated property: has exact synonym
annotated target: Grade I Astrocytoma
term-group: SY
term-source: CDISC

Axiom
annotated source: Pilocytic Astrocytoma
annotated property: has exact synonym
annotated target: Grade I Astrocytoma
term-group: SY
term-source: NCI

Axiom
annotated source: Pilocytic Astrocytoma
annotated property: has exact synonym
annotated target: Pilocytic Astrocytoma
term-group: PT
term-source: NCI

Axiom
annotated source: Pilocytic Astrocytoma
annotated property: has exact synonym
annotated target: Pilocytic Astrocytoma
term-group: SY
term-source: NCI
source-code: TCGA
subsource-name: caDSR

Axiom
annotated source: Pilocytic Astrocytoma
annotated property: has exact synonym
annotated target: Pilocytic astrocytoma
term-group: PT
term-source: CTEP
source-code: 90600112
subsource-name: SDC

Anaplastic Ependymoma
type: Class
subclass of: Ependymal Tumor
definition: A WHO grade III malignant glioma of ependymal origin with accelerated growth and an unfavorable clinical outcome, particularly in children. It is characterized by high mitotic activity, often accompanied by microvascular proliferation and pseudo-palisading necrosis. (Adapted from WHO)
Concept_In_Subset: NCIT C126659
Concept_In_Subset: NCIT C61410
Concept_In_Subset: NCIT C77526
Concept_In_Subset: NCIT C88025
code: C4049
Semantic_Type: Neoplastic Process
Preferred_Name: Anaplastic Ependymoma
UMLS_CUI: C0280788
Contributing_Source: CDISC
ALT_DEFINITION: A malignant neoplasm of ependymal origin with anaplastic cellular morphology.
ICD-O-3_Code: 9392/3
Neoplastic_Status: Malignant
Legacy_Concept_Name: Anaplastic_Ependymoma
has exact synonym: Anaplastic Ependymal Neoplasm
has exact synonym: Anaplastic Ependymal Tumor
has exact synonym: Anaplastic Ependymoma
has exact synonym: EPENDYMOMA, ANAPLASTIC, MALIGNANT
has exact synonym: Malignant Ependymoma
has exact synonym: Undifferentiated Ependymal Neoplasm
has exact synonym: Undifferentiated Ependymal Tumor
has exact synonym: Undifferentiated Ependymoma
has exact synonym: WHO Grade III Ependymal Neoplasm
has exact synonym: WHO Grade III Ependymal Tumor
has exact synonym: Who Grade III Ependymal Neoplasm
has exact synonym: Who Grade III Ependymal Tumor
in subset: oncotree slim

Axiom
annotated source: Anaplastic Ependymoma
annotated property: definition
annotated target: A WHO grade III malignant glioma of ependymal origin with accelerated growth and an unfavorable clinical outcome, particularly in children. It is characterized by high mitotic activity, often accompanied by microvascular proliferation and pseudo-palisading necrosis. (Adapted from WHO)
def-source: NCI

Axiom
annotated source: Anaplastic Ependymoma
annotated property: ALT_DEFINITION
annotated target: A malignant neoplasm of ependymal origin with anaplastic cellular morphology.
def-source: CDISC

Axiom
annotated source: Anaplastic Ependymoma
annotated property: has exact synonym
annotated target: Anaplastic Ependymal Neoplasm
term-group: SY
term-source: CDISC

Axiom
annotated source: Anaplastic Ependymoma
annotated property: has exact synonym
annotated target: Anaplastic Ependymal Neoplasm
term-group: SY
term-source: NCI

Axiom
annotated source: Anaplastic Ependymoma
annotated property: has exact synonym
annotated target: Anaplastic Ependymal Tumor
term-group: SY
term-source: CDISC

Axiom
annotated source: Anaplastic Ependymoma
annotated property: has exact synonym
annotated target: Anaplastic Ependymal Tumor
term-group: SY
term-source: NCI

Axiom
annotated source: Anaplastic Ependymoma
annotated property: has exact synonym
annotated target: Anaplastic Ependymoma
term-group: PT
term-source: NCI

Axiom
annotated source: Anaplastic Ependymoma
annotated property: has exact synonym
annotated target: Anaplastic Ependymoma
term-group: SY
term-source: NCI
source-code: TCGA
subsource-name: caDSR

Axiom
annotated source: Anaplastic Ependymoma
annotated property: has exact synonym
annotated target: EPENDYMOMA, ANAPLASTIC, MALIGNANT
term-group: PT
term-source: CDISC

Axiom
annotated source: Anaplastic Ependymoma
annotated property: has exact synonym
annotated target: Malignant Ependymoma
term-group: SY
term-source: CDISC

Axiom
annotated source: Anaplastic Ependymoma
annotated property: has exact synonym
annotated target: Malignant Ependymoma
term-group: SY
term-source: NCI

Axiom
annotated source: Anaplastic Ependymoma
annotated property: has exact synonym
annotated target: Undifferentiated Ependymal Neoplasm
term-group: SY
term-source: CDISC

Axiom
annotated source: Anaplastic Ependymoma
annotated property: has exact synonym
annotated target: Undifferentiated Ependymal Neoplasm
term-group: SY
term-source: NCI

Axiom
annotated source: Anaplastic Ependymoma
annotated property: has exact synonym
annotated target: Undifferentiated Ependymal Tumor
term-group: SY
term-source: CDISC

Axiom
annotated source: Anaplastic Ependymoma
annotated property: has exact synonym
annotated target: Undifferentiated Ependymal Tumor
term-group: SY
term-source: NCI

Axiom
annotated source: Anaplastic Ependymoma
annotated property: has exact synonym
annotated target: Undifferentiated Ependymoma
term-group: SY
term-source: CDISC

Axiom
annotated source: Anaplastic Ependymoma
annotated property: has exact synonym
annotated target: Undifferentiated Ependymoma
term-group: SY
term-source: NCI

Axiom
annotated source: Anaplastic Ependymoma
annotated property: has exact synonym
annotated target: WHO Grade III Ependymal Neoplasm
term-group: SY
term-source: NCI

Axiom
annotated source: Anaplastic Ependymoma
annotated property: has exact synonym
annotated target: WHO Grade III Ependymal Tumor
term-group: SY
term-source: NCI

Axiom
annotated source: Anaplastic Ependymoma
annotated property: has exact synonym
annotated target: Who Grade III Ependymal Neoplasm
term-group: SY
term-source: CDISC

Axiom
annotated source: Anaplastic Ependymoma
annotated property: has exact synonym
annotated target: Who Grade III Ependymal Tumor
term-group: SY
term-source: CDISC

Oligoastrocytoma
type: Class
definition: A WHO grade II tumor composed of a conspicuous mixture of two distinct neoplastic cell types morphologically resembling the tumor cells in oligodendroglioma and diffuse astrocytoma. (WHO)
Concept_In_Subset: NCIT C126659
Concept_In_Subset: NCIT C61410
Concept_In_Subset: NCIT C77526
Concept_In_Subset: NCIT C88025
code: C4050
Semantic_Type: Neoplastic Process
Preferred_Name: Oligoastrocytoma
UMLS_CUI: C0280793
Contributing_Source: CDISC
ALT_DEFINITION: A benign neoplasm of the central nervous system with an astrocytic and oligodendrocytic component.
ALT_DEFINITION: A brain tumor that forms from both oligodendrocytes and astrocytes, which are types of glial cells (cells that cover and protect nerve cells in the brain and spinal cord and help them work the way they should). An oligoastrocytoma is a type of mixed glioma.
Neoplastic_Status: Undetermined
Legacy_Concept_Name: Mixed_Astrocytoma-Oligodendroglioma
has exact synonym: GLIOMA, MIXED, BENIGN
has exact synonym: Mixed Astrocytic-Oligodendroglial Neoplasm
has exact synonym: Mixed Astrocytic-Oligodendroglial Tumor
has exact synonym: Mixed Astrocytoma-Oligodendroglioma
has exact synonym: Mixed Oligo-Astrocytoma
has exact synonym: Oligoastrocytoma
has exact synonym: WHO Grade II Mixed Glioma
has exact synonym: oligoastrocytoma
in subset: oncotree slim

Axiom
annotated source: Oligoastrocytoma
annotated property: definition
annotated target: A WHO grade II tumor composed of a conspicuous mixture of two distinct neoplastic cell types morphologically resembling the tumor cells in oligodendroglioma and diffuse astrocytoma. (WHO)
def-source: NCI

Axiom
annotated source: Oligoastrocytoma
annotated property: ALT_DEFINITION
annotated target: A benign neoplasm of the central nervous system with an astrocytic and oligodendrocytic component.
def-source: CDISC

Axiom
annotated source: Oligoastrocytoma
annotated property: ALT_DEFINITION
annotated target: A brain tumor that forms from both oligodendrocytes and astrocytes, which are types of glial cells (cells that cover and protect nerve cells in the brain and spinal cord and help them work the way they should). An oligoastrocytoma is a type of mixed glioma.
def-source: NCI-GLOSS

Axiom
annotated source: Oligoastrocytoma
annotated property: has exact synonym
annotated target: GLIOMA, MIXED, BENIGN
term-group: PT
term-source: CDISC

Axiom
annotated source: Oligoastrocytoma
annotated property: has exact synonym
annotated target: Mixed Astrocytic-Oligodendroglial Neoplasm
term-group: SY
term-source: NCI

Axiom
annotated source: Oligoastrocytoma
annotated property: has exact synonym
annotated target: Mixed Astrocytic-Oligodendroglial Tumor
term-group: SY
term-source: NCI

Axiom
annotated source: Oligoastrocytoma
annotated property: has exact synonym
annotated target: Mixed Astrocytoma-Oligodendroglioma
term-group: SY
term-source: NCI

Axiom
annotated source: Oligoastrocytoma
annotated property: has exact synonym
annotated target: Mixed Oligo-Astrocytoma
term-group: SY
term-source: NCI

Axiom
annotated source: Oligoastrocytoma
annotated property: has exact synonym
annotated target: Oligoastrocytoma
term-group: PT
term-source: NCI

Axiom
annotated source: Oligoastrocytoma
annotated property: has exact synonym
annotated target: Oligoastrocytoma
term-group: SY
term-source: NCI
source-code: TCGA
subsource-name: caDSR

Axiom
annotated source: Oligoastrocytoma
annotated property: has exact synonym
annotated target: WHO Grade II Mixed Glioma
term-group: SY
term-source: NCI

Axiom
annotated source: Oligoastrocytoma
annotated property: has exact synonym
annotated target: oligoastrocytoma
term-group: PT
term-source: NCI-GLOSS
source-code: CDR0000321382

Anaplastic (Malignant) Meningioma
type: Class
definition: A WHO grade III meningioma characterized by the presence of malignant morphologic features, including malignant cytology and a very high mitotic index (20 or more mitoses per ten high power fields).
Concept_In_Subset: NCIT C126659
Concept_In_Subset: NCIT C61410
Concept_In_Subset: NCIT C77526
Concept_In_Subset: NCIT C88025
code: C4051
Semantic_Type: Neoplastic Process
Preferred_Name: Anaplastic (Malignant) Meningioma
UMLS_CUI: C0259785
Contributing_Source: CDISC
ALT_DEFINITION: A malignant neoplasm of the meninges, exhibiting poor differentiation (anaplasia).
ALT_DEFINITION: A rare, fast-growing tumor that forms in one of the inner layers of the meninges (thin layers of tissue that cover and protect the brain and spinal cord). Malignant meningioma often spreads to other areas of the body.
ICD-O-3_Code: 9530/3
Neoplastic_Status: Malignant
Legacy_Concept_Name: Anaplastic_Malignant_Meningioma
has exact synonym: Anaplastic (Malignant) Meningioma
has exact synonym: Anaplastic Meningioma
has exact synonym: MENINGIOMA, ANAPLASTIC, MALIGNANT
has exact synonym: Malignant Meningioma
has exact synonym: Meningioma, Malignant
has exact synonym: malignant meningioma
in subset: oncotree slim

Axiom
annotated source: Anaplastic (Malignant) Meningioma
annotated property: definition
annotated target: A WHO grade III meningioma characterized by the presence of malignant morphologic features, including malignant cytology and a very high mitotic index (20 or more mitoses per ten high power fields).
def-source: NCI

Axiom
annotated source: Anaplastic (Malignant) Meningioma
annotated property: ALT_DEFINITION
annotated target: A malignant neoplasm of the meninges, exhibiting poor differentiation (anaplasia).
def-source: CDISC

Axiom
annotated source: Anaplastic (Malignant) Meningioma
annotated property: ALT_DEFINITION
annotated target: A rare, fast-growing tumor that forms in one of the inner layers of the meninges (thin layers of tissue that cover and protect the brain and spinal cord). Malignant meningioma often spreads to other areas of the body.
def-source: NCI-GLOSS

Axiom
annotated source: Anaplastic (Malignant) Meningioma
annotated property: has exact synonym
annotated target: Anaplastic (Malignant) Meningioma
term-group: PT
term-source: NCI

Axiom
annotated source: Anaplastic (Malignant) Meningioma
annotated property: has exact synonym
annotated target: Anaplastic (Malignant) Meningioma
term-group: SY
term-source: NCI
source-code: TCGA
subsource-name: caDSR

Axiom
annotated source: Anaplastic (Malignant) Meningioma
annotated property: has exact synonym
annotated target: Anaplastic Meningioma
term-group: SY
term-source: CDISC

Axiom
annotated source: Anaplastic (Malignant) Meningioma
annotated property: has exact synonym
annotated target: Anaplastic Meningioma
term-group: SY
term-source: NCI

Axiom
annotated source: Anaplastic (Malignant) Meningioma
annotated property: has exact synonym
annotated target: MENINGIOMA, ANAPLASTIC, MALIGNANT
term-group: PT
term-source: CDISC

Axiom
annotated source: Anaplastic (Malignant) Meningioma
annotated property: has exact synonym
annotated target: Malignant Meningioma
term-group: SY
term-source: CDISC

Axiom
annotated source: Anaplastic (Malignant) Meningioma
annotated property: has exact synonym
annotated target: Malignant Meningioma
term-group: SY
term-source: NCI

Axiom
annotated source: Anaplastic (Malignant) Meningioma
annotated property: has exact synonym
annotated target: Meningioma, Malignant
term-group: SY
term-source: CDISC

Axiom
annotated source: Anaplastic (Malignant) Meningioma
annotated property: has exact synonym
annotated target: Meningioma, Malignant
term-group: SY
term-source: NCI

Axiom
annotated source: Anaplastic (Malignant) Meningioma
annotated property: has exact synonym
annotated target: malignant meningioma
term-group: PT
term-source: NCI-GLOSS
source-code: CDR0000045773

Mesonephric Adenocarcinoma
type: Class
definition: An adenocarcinoma of the cervix or the vagina arising from mesonephric remnants.
code: C4072
Semantic_Type: Neoplastic Process
Preferred_Name: Mesonephric Adenocarcinoma
UMLS_CUI: C0025490
ICD-O-3_Code: 9110/3
Neoplastic_Status: Malignant
Legacy_Concept_Name: Mesonephric_Adenocarcinoma
has exact synonym: Malignant Mesonephroma
has exact synonym: Mesonephric Adenocarcinoma
in subset: oncotree slim

Axiom
annotated source: Mesonephric Adenocarcinoma
annotated property: definition
annotated target: An adenocarcinoma of the cervix or the vagina arising from mesonephric remnants.
def-source: NCI

Axiom
annotated source: Mesonephric Adenocarcinoma
annotated property: has exact synonym
annotated target: Malignant Mesonephroma
term-group: SY
term-source: NCI

Axiom
annotated source: Mesonephric Adenocarcinoma
annotated property: has exact synonym
annotated target: Mesonephric Adenocarcinoma
term-group: PT
term-source: NCI

Pancreatic Mucinous-Cystic Neoplasm
type: Class
definition: A non-invasive or invasive cystic epithelial neoplasm that affects almost exclusively females. It is characterized by the presence of columnar mucin-producing epithelial cells and ovarian-type stroma formation.
code: C41247
Semantic_Type: Neoplastic Process
Preferred_Name: Pancreatic Mucinous-Cystic Neoplasm
UMLS_CUI: C1518872
Neoplastic_Status: Undetermined
Legacy_Concept_Name: Pancreatic_Mucinous_Cystic_Neoplasm
has exact synonym: Pancreatic Mucinous Cystic Neoplasm
has exact synonym: Pancreatic Mucinous-Cystic Neoplasm
in subset: oncotree slim

Axiom
annotated source: Pancreatic Mucinous-Cystic Neoplasm
annotated property: definition
annotated target: A non-invasive or invasive cystic epithelial neoplasm that affects almost exclusively females. It is characterized by the presence of columnar mucin-producing epithelial cells and ovarian-type stroma formation.
def-source: NCI

Axiom
annotated source: Pancreatic Mucinous-Cystic Neoplasm
annotated property: has exact synonym
annotated target: Pancreatic Mucinous Cystic Neoplasm
term-group: SY
term-source: NCI

Axiom
annotated source: Pancreatic Mucinous-Cystic Neoplasm
annotated property: has exact synonym
annotated target: Pancreatic Mucinous-Cystic Neoplasm
term-group: PT
term-source: NCI

Axiom
annotated source: Pancreatic Mucinous-Cystic Neoplasm
annotated property: has exact synonym
annotated target: Pancreatic Mucinous-Cystic Neoplasm
term-group: SY
term-source: NCI
source-code: TCGA
subsource-name: caDSR

Fibrolamellar Carcinoma
type: Class
subclass of: Hepatocellular Carcinoma
definition: A distinctive type of liver cell carcinoma that arises in non-cirrhotic livers and is seen predominantly in young patients. The tumor cells are polygonal and deeply eosinophilic, and are embedded in a fibrous stroma. The prognosis is similar to classical hepatocellular carcinoma that arises in non-cirrhotic livers, and better than hepatocellular carcinoma that arises in cirrhotic livers.
Concept_In_Subset: NCIT C126659
code: C4131
Semantic_Type: Neoplastic Process
Preferred_Name: Fibrolamellar Carcinoma
UMLS_CUI: C0334287
ICD-O-3_Code: 8171/3
Neoplastic_Status: Malignant
Legacy_Concept_Name: Fibrolamellar_Hepatocellular_Carcinoma
has exact synonym: FLC
has exact synonym: Fibrolamellar Cancer
has exact synonym: Fibrolamellar Carcinoma
has exact synonym: Fibrolamellar Carcinoma of Liver Cells
has exact synonym: Fibrolamellar Carcinoma of the Liver Cells
has exact synonym: Fibrolamellar Hepatocellular Carcinoma
has exact synonym: Hepatocellular Fibrolamellar Carcinoma
has exact synonym: Liver Cell Fibrolamellar Carcinoma
has exact synonym: Oncocytic Hepatocellular Tumor
has exact synonym: Polygonal Cell Type Hepatocellular Carcinoma with Fibrous Stroma
in subset: oncotree slim

Axiom
annotated source: Fibrolamellar Carcinoma
annotated property: definition
annotated target: A distinctive type of liver cell carcinoma that arises in non-cirrhotic livers and is seen predominantly in young patients. The tumor cells are polygonal and deeply eosinophilic, and are embedded in a fibrous stroma. The prognosis is similar to classical hepatocellular carcinoma that arises in non-cirrhotic livers, and better than hepatocellular carcinoma that arises in cirrhotic livers.
def-source: NCI

Axiom
annotated source: Fibrolamellar Carcinoma
annotated property: has exact synonym
annotated target: FLC
term-group: AB
term-source: NCI

Axiom
annotated source: Fibrolamellar Carcinoma
annotated property: has exact synonym
annotated target: Fibrolamellar Cancer
term-group: DN
term-source: CTRP

Axiom
annotated source: Fibrolamellar Carcinoma
annotated property: has exact synonym
annotated target: Fibrolamellar Carcinoma
term-group: PT
term-source: NCI

Axiom
annotated source: Fibrolamellar Carcinoma
annotated property: has exact synonym
annotated target: Fibrolamellar Carcinoma
term-group: SY
term-source: NCI
source-code: TCGA
subsource-name: caDSR

Axiom
annotated source: Fibrolamellar Carcinoma
annotated property: has exact synonym
annotated target: Fibrolamellar Carcinoma of Liver Cells
term-group: SY
term-source: NCI

Axiom
annotated source: Fibrolamellar Carcinoma
annotated property: has exact synonym
annotated target: Fibrolamellar Carcinoma of the Liver Cells
term-group: SY
term-source: NCI

Axiom
annotated source: Fibrolamellar Carcinoma
annotated property: has exact synonym
annotated target: Fibrolamellar Hepatocellular Carcinoma
term-group: SY
term-source: NCI

Axiom
annotated source: Fibrolamellar Carcinoma
annotated property: has exact synonym
annotated target: Hepatocellular Fibrolamellar Carcinoma
term-group: SY
term-source: NCI

Axiom
annotated source: Fibrolamellar Carcinoma
annotated property: has exact synonym
annotated target: Liver Cell Fibrolamellar Carcinoma
term-group: SY
term-source: NCI

Axiom
annotated source: Fibrolamellar Carcinoma
annotated property: has exact synonym
annotated target: Oncocytic Hepatocellular Tumor
term-group: SY
term-source: NCI

Axiom
annotated source: Fibrolamellar Carcinoma
annotated property: has exact synonym
annotated target: Polygonal Cell Type Hepatocellular Carcinoma with Fibrous Stroma
term-group: SY
term-source: NCI

Chromophobe Renal Cell Carcinoma
type: Class
subclass of: NCIT C9385
definition: A type of carcinoma that comprises a minority of renal cell carcinomas. It is characterized by loss of chromosomes 1 and Y. Based on the cytoplasmic characteristics of the neoplastic cells, this type of carcinoma is classified as classic (typical) or eosinophilic. It has a much better prognosis than other renal cell carcinomas.
Concept_In_Subset: NCIT C126659
code: C4146
Semantic_Type: Neoplastic Process
Preferred_Name: Chromophobe Renal Cell Carcinoma
UMLS_CUI: C1266042
ICD-O-3_Code: 8270/3
ICD-O-3_Code: 8317/3
Neoplastic_Status: Malignant
Legacy_Concept_Name: Chromophobe_Renal_Cell_Carcinoma
has exact synonym: Chromophobe Adenocarcinoma
has exact synonym: Chromophobe Carcinoma
has exact synonym: Chromophobe Carcinoma of Kidney
has exact synonym: Chromophobe Carcinoma of the Kidney
has exact synonym: Chromophobe Cell Carcinoma of Kidney
has exact synonym: Chromophobe Cell Carcinoma of the Kidney
has exact synonym: Chromophobe Renal Cell Cancer
has exact synonym: Chromophobe Renal Cell Carcinoma
has exact synonym: Renal Cell Carcinoma, Chromophobe Type
in subset: oncotree slim

Axiom
annotated source: Chromophobe Renal Cell Carcinoma
annotated property: definition
annotated target: A type of carcinoma that comprises a minority of renal cell carcinomas. It is characterized by loss of chromosomes 1 and Y. Based on the cytoplasmic characteristics of the neoplastic cells, this type of carcinoma is classified as classic (typical) or eosinophilic. It has a much better prognosis than other renal cell carcinomas.
def-source: NCI

Axiom
annotated source: Chromophobe Renal Cell Carcinoma
annotated property: has exact synonym
annotated target: Chromophobe Adenocarcinoma
term-group: SY
term-source: NCI

Axiom
annotated source: Chromophobe Renal Cell Carcinoma
annotated property: has exact synonym
annotated target: Chromophobe Carcinoma
term-group: SY
term-source: NCI

Axiom
annotated source: Chromophobe Renal Cell Carcinoma
annotated property: has exact synonym
annotated target: Chromophobe Carcinoma of Kidney
term-group: SY
term-source: NCI

Axiom
annotated source: Chromophobe Renal Cell Carcinoma
annotated property: has exact synonym
annotated target: Chromophobe Carcinoma of the Kidney
term-group: SY
term-source: NCI

Axiom
annotated source: Chromophobe Renal Cell Carcinoma
annotated property: has exact synonym
annotated target: Chromophobe Cell Carcinoma of Kidney
term-group: SY
term-source: NCI

Axiom
annotated source: Chromophobe Renal Cell Carcinoma
annotated property: has exact synonym
annotated target: Chromophobe Cell Carcinoma of the Kidney
term-group: SY
term-source: NCI

Axiom
annotated source: Chromophobe Renal Cell Carcinoma
annotated property: has exact synonym
annotated target: Chromophobe Renal Cell Cancer
term-group: DN
term-source: CTRP

Axiom
annotated source: Chromophobe Renal Cell Carcinoma
annotated property: has exact synonym
annotated target: Chromophobe Renal Cell Carcinoma
term-group: PT
term-source: NCI

Axiom
annotated source: Chromophobe Renal Cell Carcinoma
annotated property: has exact synonym
annotated target: Chromophobe Renal Cell Carcinoma
term-group: SY
term-source: NCI
source-code: TCGA
subsource-name: caDSR

Axiom
annotated source: Chromophobe Renal Cell Carcinoma
annotated property: has exact synonym
annotated target: Renal Cell Carcinoma, Chromophobe Type
term-group: SY
term-source: NCI

Spiradenoma
type: Class
definition: A benign epithelial neoplasm with eccrine or apocrine differentiation, arising from the sweat glands. It usually presents as a solitary, well circumscribed, firm nodule in the face and upper trunk. It is characterized by the presence of basaloid cells forming nodules in the dermis. Cases of carcinoma arising from long standing spiradenomas have been reported.
Concept_In_Subset: NCIT C126659
code: C4170
Semantic_Type: Neoplastic Process
Preferred_Name: Spiradenoma
UMLS_CUI: C0334347
ICD-O-3_Code: 8403/0
Neoplastic_Status: Benign
Legacy_Concept_Name: Eccrine_Spiradenoma
has exact synonym: Benign Eccrine Spiradenoma
has exact synonym: Eccrine Spiradenoma
has exact synonym: Spiradenoma
in subset: oncotree slim

Axiom
annotated source: Spiradenoma
annotated property: definition
annotated target: A benign epithelial neoplasm with eccrine or apocrine differentiation, arising from the sweat glands. It usually presents as a solitary, well circumscribed, firm nodule in the face and upper trunk. It is characterized by the presence of basaloid cells forming nodules in the dermis. Cases of carcinoma arising from long standing spiradenomas have been reported.
def-source: NCI

Axiom
annotated source: Spiradenoma
annotated property: has exact synonym
annotated target: Benign Eccrine Spiradenoma
term-group: SY
term-source: NCI

Axiom
annotated source: Spiradenoma
annotated property: has exact synonym
annotated target: Eccrine Spiradenoma
term-group: SY
term-source: NCI

Axiom
annotated source: Spiradenoma
annotated property: has exact synonym
annotated target: Spiradenoma
term-group: PT
term-source: NCI

Invasive Ductal Carcinoma, Not Otherwise Specified
type: Class
subclass of: NCIT C9245
definition: The most common type of invasive breast carcinoma, accounting for approximately 70% of breast carcinomas. The gross appearance is usually typical with an irregular stellate outline. Microscopically, randomly arranged epithelial elements are seen. When large sheets of malignant cells are present, necrosis may be seen. With adequate tissue sampling, in situ carcinoma can be demonstrated in association with the infiltrating carcinoma. The in situ component is nearly always ductal but occasionally may be lobular or both.
Concept_In_Subset: NCIT C116977
Concept_In_Subset: NCIT C126659
code: C4194
Semantic_Type: Neoplastic Process
Display_Name: Invasive Ductal Carcinoma, Not Otherwise Specified
Preferred_Name: Invasive Ductal Carcinoma, Not Otherwise Specified
UMLS_CUI: C1134719
Contributing_Source: CTRP
ALT_DEFINITION: The most common type of invasive breast cancer. It starts in the cells that line the milk ducts in the breast, grows outside the ducts, and often spreads to the lymph nodes.
ICD-O-3_Code: 8500/3
ICD-O-3_Code: 8521/3
Neoplastic_Status: Malignant
Legacy_Concept_Name: Invasive_Ductal_Carcinoma_not_Otherwise_Specified
has exact synonym: Infiltrating Ductal Adenocarcinoma
has exact synonym: Infiltrating Ductal Breast Carcinoma
has exact synonym: Infiltrating Ductal Carcinoma
has exact synonym: Infiltrating Ductal Carcinoma of Breast
has exact synonym: Infiltrating Ductal Carcinoma of the Breast
has exact synonym: Invasive Ductal Adenocarcinoma
has exact synonym: Invasive Ductal Breast Carcinoma
has exact synonym: Invasive Ductal Carcinoma
has exact synonym: Invasive Ductal Carcinoma of Breast
has exact synonym: Invasive Ductal Carcinoma of the Breast
has exact synonym: Invasive Ductal Carcinoma, NOS
has exact synonym: Invasive Ductal Carcinoma, NST
has exact synonym: Invasive Ductal Carcinoma, No Specific Type
has exact synonym: Invasive Ductal Carcinoma, Not Otherwise Specified
has exact synonym: infiltrating ductal carcinoma
in subset: oncotree slim

Axiom
annotated source: Invasive Ductal Carcinoma, Not Otherwise Specified
annotated property: definition
annotated target: The most common type of invasive breast carcinoma, accounting for approximately 70% of breast carcinomas. The gross appearance is usually typical with an irregular stellate outline. Microscopically, randomly arranged epithelial elements are seen. When large sheets of malignant cells are present, necrosis may be seen. With adequate tissue sampling, in situ carcinoma can be demonstrated in association with the infiltrating carcinoma. The in situ component is nearly always ductal but occasionally may be lobular or both.
def-source: NCI

Axiom
annotated source: Invasive Ductal Carcinoma, Not Otherwise Specified
annotated property: ALT_DEFINITION
annotated target: The most common type of invasive breast cancer. It starts in the cells that line the milk ducts in the breast, grows outside the ducts, and often spreads to the lymph nodes.
def-source: NCI-GLOSS

Axiom
annotated source: Invasive Ductal Carcinoma, Not Otherwise Specified
annotated property: has exact synonym
annotated target: Infiltrating Ductal Adenocarcinoma
term-group: SY
term-source: NCI

Axiom
annotated source: Invasive Ductal Carcinoma, Not Otherwise Specified
annotated property: has exact synonym
annotated target: Infiltrating Ductal Breast Carcinoma
term-group: SY
term-source: NCI

Axiom
annotated source: Invasive Ductal Carcinoma, Not Otherwise Specified
annotated property: has exact synonym
annotated target: Infiltrating Ductal Carcinoma
term-group: SY
term-source: NCI

Axiom
annotated source: Invasive Ductal Carcinoma, Not Otherwise Specified
annotated property: has exact synonym
annotated target: Infiltrating Ductal Carcinoma of Breast
term-group: SY
term-source: NCI

Axiom
annotated source: Invasive Ductal Carcinoma, Not Otherwise Specified
annotated property: has exact synonym
annotated target: Infiltrating Ductal Carcinoma of the Breast
term-group: SY
term-source: NCI

Axiom
annotated source: Invasive Ductal Carcinoma, Not Otherwise Specified
annotated property: has exact synonym
annotated target: Invasive Ductal Adenocarcinoma
term-group: SY
term-source: NCI

Axiom
annotated source: Invasive Ductal Carcinoma, Not Otherwise Specified
annotated property: has exact synonym
annotated target: Invasive Ductal Breast Carcinoma
term-group: SY
term-source: NCI

Axiom
annotated source: Invasive Ductal Carcinoma, Not Otherwise Specified
annotated property: has exact synonym
annotated target: Invasive Ductal Carcinoma
term-group: SY
term-source: NCI

Axiom
annotated source: Invasive Ductal Carcinoma, Not Otherwise Specified
annotated property: has exact synonym
annotated target: Invasive Ductal Carcinoma of Breast
term-group: SY
term-source: NCI

Axiom
annotated source: Invasive Ductal Carcinoma, Not Otherwise Specified
annotated property: has exact synonym
annotated target: Invasive Ductal Carcinoma of the Breast
term-group: SY
term-source: NCI

Axiom
annotated source: Invasive Ductal Carcinoma, Not Otherwise Specified
annotated property: has exact synonym
annotated target: Invasive Ductal Carcinoma, NOS
term-group: SY
term-source: NCI

Axiom
annotated source: Invasive Ductal Carcinoma, Not Otherwise Specified
annotated property: has exact synonym
annotated target: Invasive Ductal Carcinoma, NST
term-group: SY
term-source: NCI

Axiom
annotated source: Invasive Ductal Carcinoma, Not Otherwise Specified
annotated property: has exact synonym
annotated target: Invasive Ductal Carcinoma, No Specific Type
term-group: SY
term-source: NCI

Axiom
annotated source: Invasive Ductal Carcinoma, Not Otherwise Specified
annotated property: has exact synonym
annotated target: Invasive Ductal Carcinoma, Not Otherwise Specified
term-group: PT
term-source: NCI

Axiom
annotated source: Invasive Ductal Carcinoma, Not Otherwise Specified
annotated property: has exact synonym
annotated target: Invasive Ductal Carcinoma, Not Otherwise Specified
term-group: SY
term-source: NCI
source-code: TCGA
subsource-name: caDSR

Axiom
annotated source: Invasive Ductal Carcinoma, Not Otherwise Specified
annotated property: has exact synonym
annotated target: infiltrating ductal carcinoma
term-group: PT
term-source: NCI-GLOSS
source-code: CDR0000045099

Atypical Fibroxanthoma
type: Class
definition: An intermediate cutaneous mesenchymal neoplasm of uncertain differentiation, usually affecting the actinic-damaged skin of the elderly. The tumor presents as a single cutaneous nodule which is often ulcerated. Microscopically, it is characterized by the presence of highly atypical cytologic features, pleomorphism and abundant mitotic figures. The vast majority of patients have an excellent prognosis following conservative therapy. Recurrences are infrequent, and metastasis is rare.
code: C4246
Semantic_Type: Neoplastic Process
Preferred_Name: Atypical Fibroxanthoma
UMLS_CUI: C0346053
ICD-O-3_Code: 8830/1
Neoplastic_Status: Undetermined
Legacy_Concept_Name: Atypical_Fibroxanthoma
has exact synonym: Atypical Cutaneous Fibroxanthoma
has exact synonym: Atypical Fibrous Histiocytoma
has exact synonym: Atypical Fibroxanthoma
has exact synonym: Atypical Fibroxanthoma of Skin
has exact synonym: Atypical Fibroxanthoma of the Skin
has exact synonym: Atypical Skin Fibroxanthoma
has exact synonym: Superficial Malignant Fibrous Histiocytoma
in subset: oncotree slim

Axiom
annotated source: Atypical Fibroxanthoma
annotated property: definition
annotated target: An intermediate cutaneous mesenchymal neoplasm of uncertain differentiation, usually affecting the actinic-damaged skin of the elderly. The tumor presents as a single cutaneous nodule which is often ulcerated. Microscopically, it is characterized by the presence of highly atypical cytologic features, pleomorphism and abundant mitotic figures. The vast majority of patients have an excellent prognosis following conservative therapy. Recurrences are infrequent, and metastasis is rare.
def-source: NCI

Axiom
annotated source: Atypical Fibroxanthoma
annotated property: has exact synonym
annotated target: Atypical Cutaneous Fibroxanthoma
term-group: SY
term-source: NCI

Axiom
annotated source: Atypical Fibroxanthoma
annotated property: has exact synonym
annotated target: Atypical Fibrous Histiocytoma
term-group: SY
term-source: NCI

Axiom
annotated source: Atypical Fibroxanthoma
annotated property: has exact synonym
annotated target: Atypical Fibroxanthoma
term-group: PT
term-source: NCI

Axiom
annotated source: Atypical Fibroxanthoma
annotated property: has exact synonym
annotated target: Atypical Fibroxanthoma of Skin
term-group: SY
term-source: NCI

Axiom
annotated source: Atypical Fibroxanthoma
annotated property: has exact synonym
annotated target: Atypical Fibroxanthoma of the Skin
term-group: SY
term-source: NCI

Axiom
annotated source: Atypical Fibroxanthoma
annotated property: has exact synonym
annotated target: Atypical Skin Fibroxanthoma
term-group: SY
term-source: NCI

Axiom
annotated source: Atypical Fibroxanthoma
annotated property: has exact synonym
annotated target: Superficial Malignant Fibrous Histiocytoma
term-group: AQS
term-source: NCI

Undifferentiated Pleomorphic Sarcoma
type: Class
definition: An undifferentiated soft tissue sarcoma characterized by the presence of a pleomorphic malignant cellular infiltrate. It is also known as malignant fibrous histiocytoma.
Concept_In_Subset: NCIT C102905
Concept_In_Subset: NCIT C103117
Concept_In_Subset: NCIT C126659
Concept_In_Subset: NCIT C61410
Concept_In_Subset: NCIT C77526
Concept_In_Subset: NCIT C88025
code: C4247
Semantic_Type: Neoplastic Process
Preferred_Name: Undifferentiated Pleomorphic Sarcoma
UMLS_CUI: C0334463
Contributing_Source: CDISC
Contributing_Source: CTEP
ALT_DEFINITION: A malignant neoplasm composed of a fibroblastic and a histiocytic component.
ALT_DEFINITION: A soft tissue sarcoma that usually occurs in the limbs, most commonly the legs, and may also occur in the abdomen.
ICD-O-3_Code: 8830/3
Neoplastic_Status: Malignant
Legacy_Concept_Name: Malignant_Fibrous_Histiocytoma
has exact synonym: Fibroxanthosarcoma
has exact synonym: HISTIOCYTOMA, FIBROUS, MALIGNANT
has exact synonym: MFH
has exact synonym: Malignant Fibrous Histiocytoma
has exact synonym: Malignant Fibrous Histiocytoma of Soft Tissue and Bone
has exact synonym: Malignant Fibrous Histiocytoma of the Soft Tissue and Bone
has exact synonym: Malignant Fibroxanthoma
has exact synonym: Malignant fibrous histiocytoma
has exact synonym: Storiform-Pleomorphic Fibrous Histiocytoma
has exact synonym: Storiform-Pleomorphic MFH
has exact synonym: Storiform-Pleomorphic Malignant Fibrous Histiocytoma
has exact synonym: UPS
has exact synonym: Unclassified Pleomorphic Sarcoma
has exact synonym: Unclassified Pleomorphic Sarcoma (Formerly "MFH")
has exact synonym: Unclassified Pleomorphic Sarcoma (Formerly "Malignant Fibrous Histiocytoma")
has exact synonym: Undifferentiated Pleomorphic Sarcoma
has exact synonym: Undifferentiated Pleomorphic Soft Tissue Sarcoma
has exact synonym: malignant fibrous cytoma
has exact synonym: malignant fibrous histiocytoma
in subset: oncotree slim

Axiom
annotated source: Undifferentiated Pleomorphic Sarcoma
annotated property: definition
annotated target: An undifferentiated soft tissue sarcoma characterized by the presence of a pleomorphic malignant cellular infiltrate. It is also known as malignant fibrous histiocytoma.
def-source: NCI

Axiom
annotated source: Undifferentiated Pleomorphic Sarcoma
annotated property: ALT_DEFINITION
annotated target: A malignant neoplasm composed of a fibroblastic and a histiocytic component.
def-source: CDISC

Axiom
annotated source: Undifferentiated Pleomorphic Sarcoma
annotated property: ALT_DEFINITION
annotated target: A soft tissue sarcoma that usually occurs in the limbs, most commonly the legs, and may also occur in the abdomen.
def-source: NCI-GLOSS

Axiom
annotated source: Undifferentiated Pleomorphic Sarcoma
annotated property: has exact synonym
annotated target: Fibroxanthosarcoma
term-group: AQS
term-source: NCI

Axiom
annotated source: Undifferentiated Pleomorphic Sarcoma
annotated property: has exact synonym
annotated target: Fibroxanthosarcoma
term-group: SY
term-source: CDISC

Axiom
annotated source: Undifferentiated Pleomorphic Sarcoma
annotated property: has exact synonym
annotated target: HISTIOCYTOMA, FIBROUS, MALIGNANT
term-group: PT
term-source: CDISC

Axiom
annotated source: Undifferentiated Pleomorphic Sarcoma
annotated property: has exact synonym
annotated target: MFH
term-group: AB
term-source: NCI

Axiom
annotated source: Undifferentiated Pleomorphic Sarcoma
annotated property: has exact synonym
annotated target: MFH
term-group: SY
term-source: CDISC

Axiom
annotated source: Undifferentiated Pleomorphic Sarcoma
annotated property: has exact synonym
annotated target: Malignant Fibrous Histiocytoma
term-group: AQS
term-source: NCI

Axiom
annotated source: Undifferentiated Pleomorphic Sarcoma
annotated property: has exact synonym
annotated target: Malignant Fibrous Histiocytoma of Soft Tissue and Bone
term-group: SY
term-source: CDISC

Axiom
annotated source: Undifferentiated Pleomorphic Sarcoma
annotated property: has exact synonym
annotated target: Malignant Fibrous Histiocytoma of the Soft Tissue and Bone
term-group: SY
term-source: CDISC

Axiom
annotated source: Undifferentiated Pleomorphic Sarcoma
annotated property: has exact synonym
annotated target: Malignant Fibroxanthoma
term-group: AQS
term-source: NCI

Axiom
annotated source: Undifferentiated Pleomorphic Sarcoma
annotated property: has exact synonym
annotated target: Malignant Fibroxanthoma
term-group: SY
term-source: CDISC

Axiom
annotated source: Undifferentiated Pleomorphic Sarcoma
annotated property: has exact synonym
annotated target: Malignant fibrous histiocytoma
term-group: PT
term-source: CTEP
source-code: 10025556
subsource-name: SDC

Axiom
annotated source: Undifferentiated Pleomorphic Sarcoma
annotated property: has exact synonym
annotated target: Storiform-Pleomorphic Fibrous Histiocytoma
term-group: AQS
term-source: NCI

Axiom
annotated source: Undifferentiated Pleomorphic Sarcoma
annotated property: has exact synonym
annotated target: Storiform-Pleomorphic MFH
term-group: AQS
term-source: NCI

Axiom
annotated source: Undifferentiated Pleomorphic Sarcoma
annotated property: has exact synonym
annotated target: Storiform-Pleomorphic Malignant Fibrous Histiocytoma
term-group: SY
term-source: NCI

Axiom
annotated source: Undifferentiated Pleomorphic Sarcoma
annotated property: has exact synonym
annotated target: UPS
term-group: AB
term-source: NCI

Axiom
annotated source: Undifferentiated Pleomorphic Sarcoma
annotated property: has exact synonym
annotated target: Unclassified Pleomorphic Sarcoma
term-group: SY
term-source: NCI

Axiom
annotated source: Undifferentiated Pleomorphic Sarcoma
annotated property: has exact synonym
annotated target: Unclassified Pleomorphic Sarcoma (Formerly "MFH")
term-group: SY
term-source: NCI

Axiom
annotated source: Undifferentiated Pleomorphic Sarcoma
annotated property: has exact synonym
annotated target: Unclassified Pleomorphic Sarcoma (Formerly "Malignant Fibrous Histiocytoma")
term-group: SY
term-source: NCI

Axiom
annotated source: Undifferentiated Pleomorphic Sarcoma
annotated property: has exact synonym
annotated target: Undifferentiated Pleomorphic Sarcoma
term-group: PT
term-source: NCI

Axiom
annotated source: Undifferentiated Pleomorphic Sarcoma
annotated property: has exact synonym
annotated target: Undifferentiated Pleomorphic Soft Tissue Sarcoma
term-group: SY
term-source: NCI

Axiom
annotated source: Undifferentiated Pleomorphic Sarcoma
annotated property: has exact synonym
annotated target: malignant fibrous cytoma
term-group: PT
term-source: NCI-GLOSS
source-code: CDR0000349461

Axiom
annotated source: Undifferentiated Pleomorphic Sarcoma
annotated property: has exact synonym
annotated target: malignant fibrous histiocytoma
term-group: PT
term-source: NCI-GLOSS
source-code: CDR0000046174

Well Differentiated Liposarcoma
type: Class
subclass of: Liposarcoma
definition: A locally aggressive malignant neoplasm composed of mature adipocytes showing cell size variation and nuclear atypia. It is often associated with the presence of hyperchromatic multinucleated stromal cells, and varying numbers of lipoblasts. There are three histologic subtypes, sclerosing, inflammatory, and spindle cell liposarcoma. These tumors do not usually metastasize unless they undergo dedifferentiation.
Concept_In_Subset: NCIT C126659
code: C4250
Semantic_Type: Neoplastic Process
Preferred_Name: Well Differentiated Liposarcoma
UMLS_CUI: C1370889
ICD-O-3_Code: 8851/3
Neoplastic_Status: Malignant
Legacy_Concept_Name: Well-Differentiated_Liposarcoma
has exact synonym: Well Differentiated Liposarcoma
has exact synonym: Well Differentiated Liposarcoma of Deep Soft Tissue
has exact synonym: Well-Differentiated Liposarcoma
in subset: oncotree slim

Axiom
annotated source: Well Differentiated Liposarcoma
annotated property: definition
annotated target: A locally aggressive malignant neoplasm composed of mature adipocytes showing cell size variation and nuclear atypia. It is often associated with the presence of hyperchromatic multinucleated stromal cells, and varying numbers of lipoblasts. There are three histologic subtypes, sclerosing, inflammatory, and spindle cell liposarcoma. These tumors do not usually metastasize unless they undergo dedifferentiation.
def-source: NCI

Axiom
annotated source: Well Differentiated Liposarcoma
annotated property: has exact synonym
annotated target: Well Differentiated Liposarcoma
term-group: PT
term-source: NCI

Axiom
annotated source: Well Differentiated Liposarcoma
annotated property: has exact synonym
annotated target: Well Differentiated Liposarcoma
term-group: SY
term-source: NCI
source-code: TCGA
subsource-name: caDSR

Axiom
annotated source: Well Differentiated Liposarcoma
annotated property: has exact synonym
annotated target: Well Differentiated Liposarcoma of Deep Soft Tissue
term-group: SY
term-source: NCI

Axiom
annotated source: Well Differentiated Liposarcoma
annotated property: has exact synonym
annotated target: Well-Differentiated Liposarcoma
term-group: SY
term-source: NCI

Pleomorphic Rhabdomyosarcoma
type: Class
subclass of: Rhabdomyosarcoma
definition: An aggressive malignant mesenchymal neoplasm with skeletal muscle differentiation, occurring in adults and rarely in children. The tumor is characterized by the presence of bizarre round, spindle, and polygonal cells. Clinical presentation includes a rapidly enlarging painful mass usually of the lower extremities.
Concept_In_Subset: NCIT C126659
code: C4258
Semantic_Type: Neoplastic Process
Preferred_Name: Pleomorphic Rhabdomyosarcoma
UMLS_CUI: C0334480
Neoplastic_Status: Malignant
Legacy_Concept_Name: Pleomorphic_Rhabdomyosarcoma
has exact synonym: Pleomorphic Rhabdomyosarcoma
in subset: oncotree slim

Axiom
annotated source: Pleomorphic Rhabdomyosarcoma
annotated property: definition
annotated target: An aggressive malignant mesenchymal neoplasm with skeletal muscle differentiation, occurring in adults and rarely in children. The tumor is characterized by the presence of bizarre round, spindle, and polygonal cells. Clinical presentation includes a rapidly enlarging painful mass usually of the lower extremities.
def-source: NCI

Axiom
annotated source: Pleomorphic Rhabdomyosarcoma
annotated property: has exact synonym
annotated target: Pleomorphic Rhabdomyosarcoma
term-group: PT
term-source: NCI

Low Grade Endometrioid Stromal Sarcoma
type: Class
subclass of: NCIT C8973
definition: An infiltrating mesenchymal tumor arising from the uterine corpus, cervix, vagina, and the ovary. It is characterized by the presence of oval to spindle-shape cells that resemble the cells of the endometrial stroma, without evidence of significant atypia and pleomorphism. Numerous small vessels are also present. It is usually characterized by indolent growth and late recurrences.
Concept_In_Subset: NCIT C126659
code: C4263
Semantic_Type: Neoplastic Process
Preferred_Name: Low Grade Endometrioid Stromal Sarcoma
UMLS_CUI: C0334486
ICD-O-3_Code: 8931/3
Neoplastic_Status: Malignant
Legacy_Concept_Name: Low_Grade_Endometrial_Stromal_Sarcoma
has exact synonym: Endolymphatic Stromal Myosis
has exact synonym: Low Grade Endometrioid Stromal Sarcoma
in subset: oncotree slim

Axiom
annotated source: Low Grade Endometrioid Stromal Sarcoma
annotated property: definition
annotated target: An infiltrating mesenchymal tumor arising from the uterine corpus, cervix, vagina, and the ovary. It is characterized by the presence of oval to spindle-shape cells that resemble the cells of the endometrial stroma, without evidence of significant atypia and pleomorphism. Numerous small vessels are also present. It is usually characterized by indolent growth and late recurrences.
def-source: NCI

Axiom
annotated source: Low Grade Endometrioid Stromal Sarcoma
annotated property: has exact synonym
annotated target: Endolymphatic Stromal Myosis
term-group: SY
term-source: NCI

Axiom
annotated source: Low Grade Endometrioid Stromal Sarcoma
annotated property: has exact synonym
annotated target: Low Grade Endometrioid Stromal Sarcoma
term-group: PT
term-source: NCI

Malignant Ovarian Brenner Tumor
type: Class
definition: A malignant neoplasm that arises from the ovary and is characterized by the presence of an invasive malignant transitional cell component and nests of benign transitional cells in a fibrotic stroma. When the neoplasm is confined to the ovary, the prognosis is good.
code: C4270
Semantic_Type: Neoplastic Process
Preferred_Name: Malignant Ovarian Brenner Tumor
UMLS_CUI: C0334495
ICD-O-3_Code: 9000/3
Neoplastic_Status: Malignant
Legacy_Concept_Name: Malignant_Brenner_Tumor
has exact synonym: Malignant Brenner Tumor of Ovary
has exact synonym: Malignant Brenner Tumor of the Ovary
has exact synonym: Malignant Ovarian Brenner Tumor
in subset: oncotree slim

Axiom
annotated source: Malignant Ovarian Brenner Tumor
annotated property: definition
annotated target: A malignant neoplasm that arises from the ovary and is characterized by the presence of an invasive malignant transitional cell component and nests of benign transitional cells in a fibrotic stroma. When the neoplasm is confined to the ovary, the prognosis is good.
def-source: NCI

Axiom
annotated source: Malignant Ovarian Brenner Tumor
annotated property: has exact synonym
annotated target: Malignant Brenner Tumor of Ovary
term-group: SY
term-source: NCI

Axiom
annotated source: Malignant Ovarian Brenner Tumor
annotated property: has exact synonym
annotated target: Malignant Brenner Tumor of the Ovary
term-group: SY
term-source: NCI

Axiom
annotated source: Malignant Ovarian Brenner Tumor
annotated property: has exact synonym
annotated target: Malignant Ovarian Brenner Tumor
term-group: PT
term-source: NCI

Uterine Carcinosarcoma
type: Class
definition: A usually aggressive malignant neoplasm arising from the uterine corpus and less often the cervix. It is characterized by the presence of two components: a malignant epithelial component and a sarcomatous component. In the uterine corpus the epithelial component is usually glandular whereas in the cervix is usually non-glandular. Carcinosarcoma of the cervix, although it is aggressive, it may have a better prognosis compared to the uterine corpus carcinosarcoma.
Concept_In_Subset: NCIT C102905
Concept_In_Subset: NCIT C103103
Concept_In_Subset: NCIT C116977
code: C42700
Semantic_Type: Neoplastic Process
Display_Name: Uterine Carcinosarcoma
Preferred_Name: Uterine Carcinosarcoma
UMLS_CUI: C0280630
Contributing_Source: CTEP
Contributing_Source: CTRP
Neoplastic_Status: Malignant
Legacy_Concept_Name: Uterine_Carcinosarcoma
has exact synonym: Carcinosarcoma of the Uterus
has exact synonym: Carcinosarcoma of the uterus
has exact synonym: Malignant Mixed Mesodermal (Mullerian) Tumor of the Uterus
has exact synonym: Malignant Mixed Mesodermal (Müllerian) Tumor of the Uterus
has exact synonym: Uterine Carcinosarcoma
has exact synonym: Uterine Malignant Mixed Mesodermal (Mullerian) Tumor
has exact synonym: Uterine Malignant Mixed Mesodermal (Müllerian) Tumor
in subset: oncotree slim

Axiom
annotated source: Uterine Carcinosarcoma
annotated property: definition
annotated target: A usually aggressive malignant neoplasm arising from the uterine corpus and less often the cervix. It is characterized by the presence of two components: a malignant epithelial component and a sarcomatous component. In the uterine corpus the epithelial component is usually glandular whereas in the cervix is usually non-glandular. Carcinosarcoma of the cervix, although it is aggressive, it may have a better prognosis compared to the uterine corpus carcinosarcoma.
def-source: NCI

Axiom
annotated source: Uterine Carcinosarcoma
annotated property: has exact synonym
annotated target: Carcinosarcoma of the Uterus
term-group: SY
term-source: NCI

Axiom
annotated source: Uterine Carcinosarcoma
annotated property: has exact synonym
annotated target: Carcinosarcoma of the uterus
term-group: PT
term-source: CTEP
source-code: 10007508
subsource-name: SDC

Axiom
annotated source: Uterine Carcinosarcoma
annotated property: has exact synonym
annotated target: Malignant Mixed Mesodermal (Mullerian) Tumor of the Uterus
term-group: SY
term-source: NCI

Axiom
annotated source: Uterine Carcinosarcoma
annotated property: has exact synonym
annotated target: Malignant Mixed Mesodermal (Müllerian) Tumor of the Uterus
term-group: SY
term-source: NCI

Axiom
annotated source: Uterine Carcinosarcoma
annotated property: has exact synonym
annotated target: Uterine Carcinosarcoma
term-group: PT
term-source: NCI

Axiom
annotated source: Uterine Carcinosarcoma
annotated property: has exact synonym
annotated target: Uterine Malignant Mixed Mesodermal (Mullerian) Tumor
term-group: SY
term-source: NCI

Axiom
annotated source: Uterine Carcinosarcoma
annotated property: has exact synonym
annotated target: Uterine Malignant Mixed Mesodermal (Müllerian) Tumor
term-group: SY
term-source: NCI

Mixed Germ Cell Tumor
type: Class
definition: A malignant germ cell tumor characterized by the presence of at least two different germ cell components. The different germ cell components include choriocarcinoma, embryonal carcinoma, yolk sac tumor, teratoma, and seminoma. It occurs in the ovary, testis, and extragonadal sites including central nervous system and mediastinum.
Concept_In_Subset: NCIT C126659
code: C4290
Semantic_Type: Neoplastic Process
Preferred_Name: Mixed Germ Cell Tumor
UMLS_CUI: C0334524
ICD-O-3_Code: 9085/3
Neoplastic_Status: Malignant
Legacy_Concept_Name: Mixed_Germ_Cell_Neoplasm
has exact synonym: Combined Germ Cell Neoplasm
has exact synonym: Combined Germ Cell Tumor
has exact synonym: Mixed Germ Cell Neoplasm
has exact synonym: Mixed Germ Cell Tumor
in subset: oncotree slim

Axiom
annotated source: Mixed Germ Cell Tumor
annotated property: definition
annotated target: A malignant germ cell tumor characterized by the presence of at least two different germ cell components. The different germ cell components include choriocarcinoma, embryonal carcinoma, yolk sac tumor, teratoma, and seminoma. It occurs in the ovary, testis, and extragonadal sites including central nervous system and mediastinum.
def-source: NCI

Axiom
annotated source: Mixed Germ Cell Tumor
annotated property: has exact synonym
annotated target: Combined Germ Cell Neoplasm
term-group: SY
term-source: NCI

Axiom
annotated source: Mixed Germ Cell Tumor
annotated property: has exact synonym
annotated target: Combined Germ Cell Tumor
term-group: SY
term-source: NCI

Axiom
annotated source: Mixed Germ Cell Tumor
annotated property: has exact synonym
annotated target: Mixed Germ Cell Neoplasm
term-group: SY
term-source: NCI

Axiom
annotated source: Mixed Germ Cell Tumor
annotated property: has exact synonym
annotated target: Mixed Germ Cell Tumor
term-group: DN
term-source: CTRP

Axiom
annotated source: Mixed Germ Cell Tumor
annotated property: has exact synonym
annotated target: Mixed Germ Cell Tumor
term-group: PT
term-source: CTRP

Axiom
annotated source: Mixed Germ Cell Tumor
annotated property: has exact synonym
annotated target: Mixed Germ Cell Tumor
term-group: PT
term-source: NCI

Axiom
annotated source: Mixed Germ Cell Tumor
annotated property: has exact synonym
annotated target: Mixed Germ Cell Tumor
term-group: SY
term-source: NCI
source-code: TCGA
subsource-name: caDSR

Partial Hydatidiform Mole
type: Class
subclass of: Hydatidiform Mole
definition: A gestational trophoblastic disorder characterized by the presence of an abnormal fetus and two populations of chorionic villi: one population which is unremarkable and a second one which shows hydropic changes.
Has_NICHD_Parent: Hydatidiform Mole
Concept_In_Subset: NCIT C118466
Concept_In_Subset: NCIT C90259
code: C4293
Semantic_Type: Disease or Syndrome
Preferred_Name: Partial Hydatidiform Mole
UMLS_CUI: C0334529
Contributing_Source: NICHD
ALT_DEFINITION: A placental disorder characterized by the presence of two populations of chorionic villi: one population which is of unremarkable development and a second one which shows hydropic changes.
ICD-O-3_Code: 9103/0
Legacy_Concept_Name: Partial_Hydatidiform_Mole
NICHD_Hierarchy_Term: Partial Hydatidiform Mole
has exact synonym: Incomplete Hydatid Mole
has exact synonym: Incomplete Hydatidiform Mole
has exact synonym: Incomplete Molar Pregnancy
has exact synonym: Partial Hydatid Mole
has exact synonym: Partial Hydatidiform Mole
has exact synonym: Partial Molar Pregnancy
has exact synonym: Partial Mole
in subset: oncotree slim

Axiom
annotated source: Partial Hydatidiform Mole
annotated property: definition
annotated target: A gestational trophoblastic disorder characterized by the presence of an abnormal fetus and two populations of chorionic villi: one population which is unremarkable and a second one which shows hydropic changes.
def-source: NCI
attr: NICHD

Axiom
annotated source: Partial Hydatidiform Mole
annotated property: ALT_DEFINITION
annotated target: A placental disorder characterized by the presence of two populations of chorionic villi: one population which is of unremarkable development and a second one which shows hydropic changes.
def-source: NICHD

Axiom
annotated source: Partial Hydatidiform Mole
annotated property: has exact synonym
annotated target: Incomplete Hydatid Mole
term-group: SY
term-source: NCI

Axiom
annotated source: Partial Hydatidiform Mole
annotated property: has exact synonym
annotated target: Incomplete Hydatidiform Mole
term-group: SY
term-source: NCI

Axiom
annotated source: Partial Hydatidiform Mole
annotated property: has exact synonym
annotated target: Incomplete Hydatidiform Mole
term-group: SY
term-source: NICHD

Axiom
annotated source: Partial Hydatidiform Mole
annotated property: has exact synonym
annotated target: Incomplete Molar Pregnancy
term-group: SY
term-source: NCI

Axiom
annotated source: Partial Hydatidiform Mole
annotated property: has exact synonym
annotated target: Partial Hydatid Mole
term-group: SY
term-source: NCI

Axiom
annotated source: Partial Hydatidiform Mole
annotated property: has exact synonym
annotated target: Partial Hydatidiform Mole
term-group: PT
term-source: NCI

Axiom
annotated source: Partial Hydatidiform Mole
annotated property: has exact synonym
annotated target: Partial Hydatidiform Mole
term-group: PT
term-source: NICHD

Axiom
annotated source: Partial Hydatidiform Mole
annotated property: has exact synonym
annotated target: Partial Molar Pregnancy
term-group: SY
term-source: NCI

Axiom
annotated source: Partial Hydatidiform Mole
annotated property: has exact synonym
annotated target: Partial Mole
term-group: SY
term-source: NCI

Myxoid Chondrosarcoma
type: Class
subclass of: Chondrosarcoma
definition: A chondrosarcoma characterized by the presence of myxoid changes.
Concept_In_Subset: NCIT C126659
code: C4303
Semantic_Type: Neoplastic Process
Preferred_Name: Myxoid Chondrosarcoma
UMLS_CUI: C0334551
ICD-O-3_Code: 9231/3
Neoplastic_Status: Malignant
Legacy_Concept_Name: Myxoid_Chondrosarcoma
has exact synonym: Myxoid Chondrosarcoma
in subset: oncotree slim

Axiom
annotated source: Myxoid Chondrosarcoma
annotated property: definition
annotated target: A chondrosarcoma characterized by the presence of myxoid changes.
def-source: NCI

Axiom
annotated source: Myxoid Chondrosarcoma
annotated property: has exact synonym
annotated target: Myxoid Chondrosarcoma
term-group: PT
term-source: NCI

Pleomorphic Xanthoastrocytoma
type: Class
subclass of: Astrocytoma
definition: A WHO grade ll astrocytic tumor with a relatively favorable prognosis. It is characterized by pleomorphic and lipidized cells expressing GFAP often surrounded by a reticulin network and eosinophilic granular bodies. It presents in the superficial cerebral hemispheres and involves the meninges. It typically affects children and young adults.
Concept_In_Subset: NCIT C126659
code: C4323
Semantic_Type: Neoplastic Process
Preferred_Name: Pleomorphic Xanthoastrocytoma
UMLS_CUI: C0334586
ICD-O-3_Code: 9424/3
Neoplastic_Status: Undetermined
Legacy_Concept_Name: Pleomorphic_Xanthoastrocytoma
has exact synonym: Pleomorphic Xantho-Astrocytoma
has exact synonym: Pleomorphic Xanthoastrocytoma
in subset: oncotree slim

Axiom
annotated source: Pleomorphic Xanthoastrocytoma
annotated property: definition
annotated target: A WHO grade ll astrocytic tumor with a relatively favorable prognosis. It is characterized by pleomorphic and lipidized cells expressing GFAP often surrounded by a reticulin network and eosinophilic granular bodies. It presents in the superficial cerebral hemispheres and involves the meninges. It typically affects children and young adults.
def-source: NCI

Axiom
annotated source: Pleomorphic Xanthoastrocytoma
annotated property: has exact synonym
annotated target: Pleomorphic Xantho-Astrocytoma
term-group: SY
term-source: NCI

Axiom
annotated source: Pleomorphic Xanthoastrocytoma
annotated property: has exact synonym
annotated target: Pleomorphic Xanthoastrocytoma
term-group: PT
term-source: NCI

Axiom
annotated source: Pleomorphic Xanthoastrocytoma
annotated property: has exact synonym
annotated target: Pleomorphic Xanthoastrocytoma
term-group: SY
term-source: NCI
source-code: TCGA
subsource-name: caDSR

Astroblastoma
type: Class
definition: A rare glial neoplasm more commonly found in young adults. It is characterized by tumor cells with characteristics suggestive of an astrocytic origin (positive for GFAP), arranged perivascularly. The cells have broad, non-tapering processes radiating towards a central blood vessel. The biologic behavior of astroblastomas is variable, so no WHO grade has been established, yet. (Adapted from WHO.)
Concept_In_Subset: NCIT C126659
code: C4324
Semantic_Type: Neoplastic Process
Preferred_Name: Astroblastoma
UMLS_CUI: C0334587
ICD-O-3_Code: 9430/3
Neoplastic_Status: Undetermined
Legacy_Concept_Name: Astroblastoma
has exact synonym: Astroblastoma
in subset: oncotree slim

Axiom
annotated source: Astroblastoma
annotated property: definition
annotated target: A rare glial neoplasm more commonly found in young adults. It is characterized by tumor cells with characteristics suggestive of an astrocytic origin (positive for GFAP), arranged perivascularly. The cells have broad, non-tapering processes radiating towards a central blood vessel. The biologic behavior of astroblastomas is variable, so no WHO grade has been established, yet. (Adapted from WHO.)
def-source: NCI

Axiom
annotated source: Astroblastoma
annotated property: has exact synonym
annotated target: Astroblastoma
term-group: PT
term-source: NCI

Anaplastic Oligodendroglioma
type: Class
definition: A WHO grade III oligodendroglioma with focal or diffuse malignant morphologic features (prominent nuclear pleomorphism, mitoses, and increased cellularity).
Concept_In_Subset: NCIT C102905
Concept_In_Subset: NCIT C103050
Concept_In_Subset: NCIT C126659
Concept_In_Subset: NCIT C61410
Concept_In_Subset: NCIT C77526
Concept_In_Subset: NCIT C88025
code: C4326
Semantic_Type: Neoplastic Process
Preferred_Name: Anaplastic Oligodendroglioma
UMLS_CUI: C0334590
Contributing_Source: CDISC
Contributing_Source: CTEP
ALT_DEFINITION: A malignant neoplasm of the central nervous system arising from oligodendrocytes, exhibiting poor differentiation (anaplasia).
ICD-O-3_Code: 9451/3
Neoplastic_Status: Malignant
Legacy_Concept_Name: Anaplastic_Oligodendroglioma
has exact synonym: Anaplastic Oligodendroglioma
has exact synonym: Anaplastic oligodendroglioma
has exact synonym: Malignant Oligodendroglioma
has exact synonym: OLIGODENDROGLIOMA, ANAPLASTIC, MALIGNANT
has exact synonym: Oligodendroglioma, Malignant
has exact synonym: Undifferentiated Oligodendroglioma
has exact synonym: WHO Grade III Oligodendroglial Neoplasm
has exact synonym: WHO Grade III Oligodendroglial Tumor
has exact synonym: Who Grade III Oligodendroglial Neoplasm
has exact synonym: Who Grade III Oligodendroglial Tumor
in subset: oncotree slim

Axiom
annotated source: Anaplastic Oligodendroglioma
annotated property: definition
annotated target: A WHO grade III oligodendroglioma with focal or diffuse malignant morphologic features (prominent nuclear pleomorphism, mitoses, and increased cellularity).
def-source: NCI

Axiom
annotated source: Anaplastic Oligodendroglioma
annotated property: ALT_DEFINITION
annotated target: A malignant neoplasm of the central nervous system arising from oligodendrocytes, exhibiting poor differentiation (anaplasia).
def-source: CDISC

Axiom
annotated source: Anaplastic Oligodendroglioma
annotated property: has exact synonym
annotated target: Anaplastic Oligodendroglioma
term-group: PT
term-source: NCI

Axiom
annotated source: Anaplastic Oligodendroglioma
annotated property: has exact synonym
annotated target: Anaplastic Oligodendroglioma
term-group: SY
term-source: NCI
source-code: TCGA
subsource-name: caDSR

Axiom
annotated source: Anaplastic Oligodendroglioma
annotated property: has exact synonym
annotated target: Anaplastic oligodendroglioma
term-group: PT
term-source: CTEP
source-code: 10026659
subsource-name: SDC

Axiom
annotated source: Anaplastic Oligodendroglioma
annotated property: has exact synonym
annotated target: Malignant Oligodendroglioma
term-group: SY
term-source: CDISC

Axiom
annotated source: Anaplastic Oligodendroglioma
annotated property: has exact synonym
annotated target: Malignant Oligodendroglioma
term-group: SY
term-source: NCI

Axiom
annotated source: Anaplastic Oligodendroglioma
annotated property: has exact synonym
annotated target: OLIGODENDROGLIOMA, ANAPLASTIC, MALIGNANT
term-group: PT
term-source: CDISC

Axiom
annotated source: Anaplastic Oligodendroglioma
annotated property: has exact synonym
annotated target: Oligodendroglioma, Malignant
term-group: SY
term-source: NCI

Axiom
annotated source: Anaplastic Oligodendroglioma
annotated property: has exact synonym
annotated target: Undifferentiated Oligodendroglioma
term-group: SY
term-source: CDISC

Axiom
annotated source: Anaplastic Oligodendroglioma
annotated property: has exact synonym
annotated target: Undifferentiated Oligodendroglioma
term-group: SY
term-source: NCI

Axiom
annotated source: Anaplastic Oligodendroglioma
annotated property: has exact synonym
annotated target: WHO Grade III Oligodendroglial Neoplasm
term-group: SY
term-source: NCI

Axiom
annotated source: Anaplastic Oligodendroglioma
annotated property: has exact synonym
annotated target: WHO Grade III Oligodendroglial Tumor
term-group: SY
term-source: NCI

Axiom
annotated source: Anaplastic Oligodendroglioma
annotated property: has exact synonym
annotated target: Who Grade III Oligodendroglial Neoplasm
term-group: SY
term-source: CDISC

Axiom
annotated source: Anaplastic Oligodendroglioma
annotated property: has exact synonym
annotated target: Who Grade III Oligodendroglial Tumor
term-group: SY
term-source: CDISC

Medulloepithelioma
type: Class
definition: A rare, usually aggressive malignant embryonal neoplasm of the central nervous system occurring in children. It is characterized by the presence of neuroepithelial cells which form papillary, trabecular, or tubular structures and absence of C19MC amplification. Symptoms include headache, nausea, and vomiting.
Has_NICHD_Parent: NCIT C5961
Concept_In_Subset: NCIT C116977
Concept_In_Subset: NCIT C126659
Concept_In_Subset: NCIT C132009
Concept_In_Subset: NCIT C90259
code: C4327
Semantic_Type: Neoplastic Process
Display_Name: Medulloepithelioma
Preferred_Name: Medulloepithelioma
UMLS_CUI: C0334596
Contributing_Source: CTRP
Contributing_Source: NICHD
ALT_DEFINITION: A rare malignant embryonal neoplasm of the central nervous system, occurring in children. It is characterized by the presence of neuroepithelial cells that form papillary, trabecular, or tubular structures.
Neoplastic_Status: Malignant
Legacy_Concept_Name: Medulloepithelioma
NICHD_Hierarchy_Term: Medulloepithelioma
has exact synonym: Central Nervous System Medulloepithelioma
has exact synonym: Medulloepithelioma
has exact synonym: Medulloepithelioma, Central Nervous System
in subset: oncotree slim

Axiom
annotated source: Medulloepithelioma
annotated property: definition
annotated target: A rare, usually aggressive malignant embryonal neoplasm of the central nervous system occurring in children. It is characterized by the presence of neuroepithelial cells which form papillary, trabecular, or tubular structures and absence of C19MC amplification. Symptoms include headache, nausea, and vomiting.
def-source: NCI

Axiom
annotated source: Medulloepithelioma
annotated property: ALT_DEFINITION
annotated target: A rare malignant embryonal neoplasm of the central nervous system, occurring in children. It is characterized by the presence of neuroepithelial cells that form papillary, trabecular, or tubular structures.
def-source: NICHD

Axiom
annotated source: Medulloepithelioma
annotated property: has exact synonym
annotated target: Central Nervous System Medulloepithelioma
term-group: SY
term-source: NCI

Axiom
annotated source: Medulloepithelioma
annotated property: has exact synonym
annotated target: Medulloepithelioma
term-group: PT
term-source: NCI

Axiom
annotated source: Medulloepithelioma
annotated property: has exact synonym
annotated target: Medulloepithelioma
term-group: PT
term-source: NICHD

Axiom
annotated source: Medulloepithelioma
annotated property: has exact synonym
annotated target: Medulloepithelioma, Central Nervous System
term-group: SY
term-source: NCI

Mantle Cell Lymphoma
type: Class
definition: An aggressive, usually diffuse non-Hodgkin lymphoma composed of small to medium sized B-lymphocytes (centrocytes). Most patients present with advanced stage disease with lymphadenopathy, hepatosplenomegaly, and bone marrow involvement. The gastrointestinal tract is the most commonly affected extranodal site by this type of non-Hodgkin lymphoma. The vast majority of cases express the t(11;14)(q13;q32) resulting in the rearrangement of the BCL-1 gene and the overexpression of cyclin D1 mRNA.
Concept_In_Subset: NCIT C102905
Concept_In_Subset: NCIT C103133
Concept_In_Subset: NCIT C116977
Concept_In_Subset: NCIT C126659
code: C4337
Semantic_Type: Neoplastic Process
Display_Name: Mantle Cell Lymphoma
Preferred_Name: Mantle Cell Lymphoma
UMLS_CUI: C0334634
Contributing_Source: CTEP
Contributing_Source: CTRP
ALT_DEFINITION: An aggressive (fast-growing) type of B-cell non-Hodgkin lymphoma that usually occurs in middle-aged or older adults. It is marked by small- to medium-size cancer cells that may be in the lymph nodes, spleen, bone marrow, blood, and gastrointestinal system.
ICD-O-3_Code: 9673/3
Neoplastic_Status: Malignant
Legacy_Concept_Name: Mantle_Cell_Lymphoma
has exact synonym: MCL
has exact synonym: Mantle Cell Lymphoma
has exact synonym: Mantle Zone Lymphoma
has exact synonym: Mantle cell lymphoma
has exact synonym: mantle cell lymphoma
in subset: oncotree slim

Axiom
annotated source: Mantle Cell Lymphoma
annotated property: definition
annotated target: An aggressive, usually diffuse non-Hodgkin lymphoma composed of small to medium sized B-lymphocytes (centrocytes). Most patients present with advanced stage disease with lymphadenopathy, hepatosplenomegaly, and bone marrow involvement. The gastrointestinal tract is the most commonly affected extranodal site by this type of non-Hodgkin lymphoma. The vast majority of cases express the t(11;14)(q13;q32) resulting in the rearrangement of the BCL-1 gene and the overexpression of cyclin D1 mRNA.
def-source: NCI

Axiom
annotated source: Mantle Cell Lymphoma
annotated property: ALT_DEFINITION
annotated target: An aggressive (fast-growing) type of B-cell non-Hodgkin lymphoma that usually occurs in middle-aged or older adults. It is marked by small- to medium-size cancer cells that may be in the lymph nodes, spleen, bone marrow, blood, and gastrointestinal system.
def-source: NCI-GLOSS

Axiom
annotated source: Mantle Cell Lymphoma
annotated property: has exact synonym
annotated target: MCL
term-group: AB
term-source: NCI

Axiom
annotated source: Mantle Cell Lymphoma
annotated property: has exact synonym
annotated target: Mantle Cell Lymphoma
term-group: DN
term-source: CTRP

Axiom
annotated source: Mantle Cell Lymphoma
annotated property: has exact synonym
annotated target: Mantle Cell Lymphoma
term-group: PT
term-source: NCI

Axiom
annotated source: Mantle Cell Lymphoma
annotated property: has exact synonym
annotated target: Mantle Cell Lymphoma
term-group: SY
term-source: NCI
source-code: TCGA
subsource-name: caDSR

Axiom
annotated source: Mantle Cell Lymphoma
annotated property: has exact synonym
annotated target: Mantle Zone Lymphoma
term-group: SY
term-source: NCI

Axiom
annotated source: Mantle Cell Lymphoma
annotated property: has exact synonym
annotated target: Mantle cell lymphoma
term-group: PT
term-source: CTEP
source-code: 10026799
subsource-name: SDC

Axiom
annotated source: Mantle Cell Lymphoma
annotated property: has exact synonym
annotated target: mantle cell lymphoma
term-group: PT
term-source: NCI-GLOSS
source-code: CDR0000445048

Peripheral T-Cell Lymphoma, Not Otherwise Specified
type: Class
definition: Aggressive nodal or extranodal mature (peripheral) T-cell lymphomas that do not belong to the better defined entities of the remainder of mature T-cell lymphomas. This category includes the following variants: lymphoepithelioid cell variant (Lennert's lymphoma), follicular variant, and T-zone variant.
Concept_In_Subset: NCIT C102905
Concept_In_Subset: NCIT C103133
Concept_In_Subset: NCIT C126659
code: C4340
Semantic_Type: Neoplastic Process
Preferred_Name: Peripheral T-Cell Lymphoma, Not Otherwise Specified
UMLS_CUI: C2853959
Contributing_Source: CTEP
Neoplastic_Status: Malignant
Legacy_Concept_Name: Unspecified_Peripheral_T-Cell_Lymphoma
has exact synonym: Peripheral T-Cell Lymphoma, NOS
has exact synonym: Peripheral T-Cell Lymphoma, Not Otherwise Specified
has exact synonym: Peripheral T-cell lymphoma, NOS
in subset: oncotree slim

Axiom
annotated source: Peripheral T-Cell Lymphoma, Not Otherwise Specified
annotated property: definition
annotated target: Aggressive nodal or extranodal mature (peripheral) T-cell lymphomas that do not belong to the better defined entities of the remainder of mature T-cell lymphomas. This category includes the following variants: lymphoepithelioid cell variant (Lennert's lymphoma), follicular variant, and T-zone variant.
def-source: NCI

Axiom
annotated source: Peripheral T-Cell Lymphoma, Not Otherwise Specified
annotated property: has exact synonym
annotated target: Peripheral T-Cell Lymphoma, NOS
term-group: SY
term-source: NCI

Axiom
annotated source: Peripheral T-Cell Lymphoma, Not Otherwise Specified
annotated property: has exact synonym
annotated target: Peripheral T-Cell Lymphoma, Not Otherwise Specified
term-group: PT
term-source: NCI

Axiom
annotated source: Peripheral T-Cell Lymphoma, Not Otherwise Specified
annotated property: has exact synonym
annotated target: Peripheral T-Cell Lymphoma, Not Otherwise Specified
term-group: SY
term-source: NCI
source-code: TCGA
subsource-name: caDSR

Axiom
annotated source: Peripheral T-Cell Lymphoma, Not Otherwise Specified
annotated property: has exact synonym
annotated target: Peripheral T-cell lymphoma, NOS
term-group: PT
term-source: CTEP
source-code: 10034624
subsource-name: SDC

Marginal Zone Lymphoma
type: Class
definition: A usually indolent mature B-cell lymphoma, arising from the marginal zone of lymphoid tissues. It is characterized by the presence of small to medium sized atypical lymphocytes. It comprises three entities, according to the anatomic sites involved: extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue, which affects extranodal sites (most often stomach, lung, skin, and ocular adnexa); nodal marginal zone B-cell lymphoma, which affects lymph nodes without evidence of extranodal disease; and splenic marginal zone B-cell lymphoma, which affects the spleen and splenic hilar lymph nodes, bone marrow, and often the peripheral blood.
Concept_In_Subset: NCIT C116977
Concept_In_Subset: NCIT C126659
code: C4341
Semantic_Type: Neoplastic Process
Display_Name: Marginal Zone Lymphoma
Preferred_Name: Marginal Zone Lymphoma
UMLS_CUI: C1367654
Contributing_Source: CTRP
ALT_DEFINITION: An indolent (slow-growing) type of B-cell non-Hodgkin lymphoma that begins forming in certain areas (the marginal zones) of lymph tissue. There are three types based on whether it forms in the spleen, lymph nodes, or other lymphoid tissue that contains a lot of B cells (a type of white blood cell).
ICD-O-3_Code: 9699/3
Neoplastic_Status: Malignant
Legacy_Concept_Name: Marginal_Zone_B-Cell_Lymphoma
has exact synonym: MZBCL
has exact synonym: MZL
has exact synonym: Marginal Zone B-Cell Lymphoma
has exact synonym: Marginal Zone Lymphoma
has exact synonym: marginal zone B-cell lymphoma
has exact synonym: marginal zone lymphoma
in subset: oncotree slim

Axiom
annotated source: Marginal Zone Lymphoma
annotated property: definition
annotated target: A usually indolent mature B-cell lymphoma, arising from the marginal zone of lymphoid tissues. It is characterized by the presence of small to medium sized atypical lymphocytes. It comprises three entities, according to the anatomic sites involved: extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue, which affects extranodal sites (most often stomach, lung, skin, and ocular adnexa); nodal marginal zone B-cell lymphoma, which affects lymph nodes without evidence of extranodal disease; and splenic marginal zone B-cell lymphoma, which affects the spleen and splenic hilar lymph nodes, bone marrow, and often the peripheral blood.
def-source: NCI

Axiom
annotated source: Marginal Zone Lymphoma
annotated property: ALT_DEFINITION
annotated target: An indolent (slow-growing) type of B-cell non-Hodgkin lymphoma that begins forming in certain areas (the marginal zones) of lymph tissue. There are three types based on whether it forms in the spleen, lymph nodes, or other lymphoid tissue that contains a lot of B cells (a type of white blood cell).
def-source: NCI-GLOSS

Axiom
annotated source: Marginal Zone Lymphoma
annotated property: has exact synonym
annotated target: MZBCL
term-group: AB
term-source: NCI

Axiom
annotated source: Marginal Zone Lymphoma
annotated property: has exact synonym
annotated target: MZL
term-group: AB
term-source: NCI

Axiom
annotated source: Marginal Zone Lymphoma
annotated property: has exact synonym
annotated target: MZL
term-group: PT
term-source: NCI-GLOSS
source-code: CDR0000562555

Axiom
annotated source: Marginal Zone Lymphoma
annotated property: has exact synonym
annotated target: Marginal Zone B-Cell Lymphoma
term-group: SY
term-source: NCI

Axiom
annotated source: Marginal Zone Lymphoma
annotated property: has exact synonym
annotated target: Marginal Zone Lymphoma
term-group: DN
term-source: CTRP

Axiom
annotated source: Marginal Zone Lymphoma
annotated property: has exact synonym
annotated target: Marginal Zone Lymphoma
term-group: PT
term-source: NCI

Axiom
annotated source: Marginal Zone Lymphoma
annotated property: has exact synonym
annotated target: marginal zone B-cell lymphoma
term-group: PT
term-source: NCI-GLOSS
source-code: CDR0000562554

Axiom
annotated source: Marginal Zone Lymphoma
annotated property: has exact synonym
annotated target: marginal zone lymphoma
term-group: PT
term-source: NCI-GLOSS
source-code: CDR0000543124

Myeloproliferative Neoplasm
type: Class
definition: A clonal hematopoietic stem cell disorder, characterized by proliferation in the bone marrow of one or more of the myeloid (i.e., granulocytic, erythroid, megakaryocytic, and mast cell) lineages. It is primarily a neoplasm of adults. (WHO 2008)
Concept_In_Subset: NCIT C116977
Concept_In_Subset: NCIT C126659
code: C4345
Semantic_Type: Neoplastic Process
Display_Name: Myeloproliferative Neoplasm
Preferred_Name: Myeloproliferative Neoplasm
UMLS_CUI: C1292778
Contributing_Source: CTRP
ALT_DEFINITION: A group of slow growing blood cancers, including chronic myelogenous leukemia, in which large numbers of abnormal red blood cells, white blood cells, or platelets grow and spread in the bone marrow and the peripheral blood.
ICD-O-3_Code: 9960/3
ICD-O-3_Code: 9975/1
Neoplastic_Status: Malignant
Legacy_Concept_Name: Chronic_Myeloproliferative_Disorder
has exact synonym: CMPD
has exact synonym: Chronic Myeloproliferative Disease
has exact synonym: Chronic Myeloproliferative Disorder
has exact synonym: Chronic Myeloproliferative Neoplasm
has exact synonym: MPD
has exact synonym: MPN
has exact synonym: Myeloproliferative Disorder
has exact synonym: Myeloproliferative Neoplasm
has exact synonym: Myeloproliferative Tumor
has exact synonym: myeloproliferative disorder
in subset: oncotree slim

Axiom
annotated source: Myeloproliferative Neoplasm
annotated property: definition
annotated target: A clonal hematopoietic stem cell disorder, characterized by proliferation in the bone marrow of one or more of the myeloid (i.e., granulocytic, erythroid, megakaryocytic, and mast cell) lineages. It is primarily a neoplasm of adults. (WHO 2008)
def-source: NCI

Axiom
annotated source: Myeloproliferative Neoplasm
annotated property: ALT_DEFINITION
annotated target: A group of slow growing blood cancers, including chronic myelogenous leukemia, in which large numbers of abnormal red blood cells, white blood cells, or platelets grow and spread in the bone marrow and the peripheral blood.
def-source: NCI-GLOSS

Axiom
annotated source: Myeloproliferative Neoplasm
annotated property: has exact synonym
annotated target: CMPD
term-group: AB
term-source: NCI

Axiom
annotated source: Myeloproliferative Neoplasm
annotated property: has exact synonym
annotated target: Chronic Myeloproliferative Disease
term-group: SY
term-source: NCI

Axiom
annotated source: Myeloproliferative Neoplasm
annotated property: has exact synonym
annotated target: Chronic Myeloproliferative Disorder
term-group: SY
term-source: NCI

Axiom
annotated source: Myeloproliferative Neoplasm
annotated property: has exact synonym
annotated target: Chronic Myeloproliferative Neoplasm
term-group: SY
term-source: NCI

Axiom
annotated source: Myeloproliferative Neoplasm
annotated property: has exact synonym
annotated target: MPD
term-group: SY
term-source: NCI
source-code: MPN-SAF
subsource-name: caDSR

Axiom
annotated source: Myeloproliferative Neoplasm
annotated property: has exact synonym
annotated target: MPN
term-group: AB
term-source: NCI

Axiom
annotated source: Myeloproliferative Neoplasm
annotated property: has exact synonym
annotated target: Myeloproliferative Disorder
term-group: SY
term-source: NCI

Axiom
annotated source: Myeloproliferative Neoplasm
annotated property: has exact synonym
annotated target: Myeloproliferative Neoplasm
term-group: PT
term-source: NCI

Axiom
annotated source: Myeloproliferative Neoplasm
annotated property: has exact synonym
annotated target: Myeloproliferative Tumor
term-group: SY
term-source: NCI

Axiom
annotated source: Myeloproliferative Neoplasm
annotated property: has exact synonym
annotated target: myeloproliferative disorder
term-group: PT
term-source: NCI-GLOSS
source-code: CDR0000045210

Colon Adenocarcinoma
type: Class
subclass of: Colorectal Adenocarcinoma
definition: An adenocarcinoma arising from the colon. It is more frequently seen in populations with a Western type diet and in patients with a history of chronic inflammatory bowel disease. Signs and symptoms include intestinal bleeding, anemia, and change in bowel habits. According to the degree of cellular differentiation, colonic adenocarcinomas are divided into well, moderately, and poorly differentiated. Histologic variants include mucinous adenocarcinoma, signet ring cell carcinoma, medullary carcinoma, serrated adenocarcinoma, cribriform comedo-type adenocarcinoma, and micropapillary adenocarcinoma.
Concept_In_Subset: NCIT C102905
Concept_In_Subset: NCIT C103063
Concept_In_Subset: NCIT C116977
Concept_In_Subset: NCIT C126659
code: C4349
Semantic_Type: Neoplastic Process
Display_Name: Colon Adenocarcinoma
Preferred_Name: Colon Adenocarcinoma
UMLS_CUI: C0338106
Contributing_Source: CTEP
Contributing_Source: CTRP
Neoplastic_Status: Malignant
Legacy_Concept_Name: Colon_Adenocarcinoma
has exact synonym: Adenocarcinoma - colon
has exact synonym: Adenocarcinoma of Colon
has exact synonym: Adenocarcinoma of the Colon
has exact synonym: Adenocarcinoma of the colon
has exact synonym: Colon Adenocarcinoma
has exact synonym: Colonic Adenocarcinoma
in subset: oncotree slim

Axiom
annotated source: Colon Adenocarcinoma
annotated property: definition
annotated target: An adenocarcinoma arising from the colon. It is more frequently seen in populations with a Western type diet and in patients with a history of chronic inflammatory bowel disease. Signs and symptoms include intestinal bleeding, anemia, and change in bowel habits. According to the degree of cellular differentiation, colonic adenocarcinomas are divided into well, moderately, and poorly differentiated. Histologic variants include mucinous adenocarcinoma, signet ring cell carcinoma, medullary carcinoma, serrated adenocarcinoma, cribriform comedo-type adenocarcinoma, and micropapillary adenocarcinoma.
def-source: NCI

Axiom
annotated source: Colon Adenocarcinoma
annotated property: has exact synonym
annotated target: Adenocarcinoma - colon
term-group: SY
term-source: CTEP
source-code: 10009951
subsource-name: SDC

Axiom
annotated source: Colon Adenocarcinoma
annotated property: has exact synonym
annotated target: Adenocarcinoma of Colon
term-group: SY
term-source: NCI

Axiom
annotated source: Colon Adenocarcinoma
annotated property: has exact synonym
annotated target: Adenocarcinoma of the Colon
term-group: SY
term-source: NCI

Axiom
annotated source: Colon Adenocarcinoma
annotated property: has exact synonym
annotated target: Adenocarcinoma of the colon
term-group: PT
term-source: CTEP
source-code: 10009951
subsource-name: SDC

Axiom
annotated source: Colon Adenocarcinoma
annotated property: has exact synonym
annotated target: Colon Adenocarcinoma
term-group: DN
term-source: CTRP

Axiom
annotated source: Colon Adenocarcinoma
annotated property: has exact synonym
annotated target: Colon Adenocarcinoma
term-group: PT
term-source: NCI

Axiom
annotated source: Colon Adenocarcinoma
annotated property: has exact synonym
annotated target: Colon Adenocarcinoma
term-group: SY
term-source: NCI
source-code: TCGA
subsource-name: caDSR

Axiom
annotated source: Colon Adenocarcinoma
annotated property: has exact synonym
annotated target: Colonic Adenocarcinoma
term-group: SY
term-source: NCI

Appendix Signet Ring Cell Carcinoma
type: Class
subclass of: Appendix Adenocarcinoma
definition: An adenocarcinoma arising from the appendix, characterized by the presence of signet-ring, mucin-producing malignant cells. The signet-ring cells constitute more than fifty-percent of the malignant cells.
Concept_In_Subset: NCIT C126659
code: C43554
Semantic_Type: Neoplastic Process
Preferred_Name: Appendix Signet Ring Cell Carcinoma
UMLS_CUI: C1711320
Neoplastic_Status: Malignant
Legacy_Concept_Name: Appendix_Signet_Ring_Cell_Carcinoma
has exact synonym: Appendix Signet Ring Cell Carcinoma
in subset: oncotree slim

Axiom
annotated source: Appendix Signet Ring Cell Carcinoma
annotated property: definition
annotated target: An adenocarcinoma arising from the appendix, characterized by the presence of signet-ring, mucin-producing malignant cells. The signet-ring cells constitute more than fifty-percent of the malignant cells.
def-source: NCI

Axiom
annotated source: Appendix Signet Ring Cell Carcinoma
annotated property: has exact synonym
annotated target: Appendix Signet Ring Cell Carcinoma
term-group: PT
term-source: NCI

Appendix Mucinous Adenocarcinoma
type: Class
subclass of: Mucinous Adenocarcinoma
subclass of: Appendix Adenocarcinoma
definition: An adenocarcinoma arising from the appendix, characterized by the presence of mucinous stroma formation.
Concept_In_Subset: NCIT C126659
code: C43558
Semantic_Type: Neoplastic Process
Preferred_Name: Appendix Mucinous Adenocarcinoma
UMLS_CUI: C1706832
Neoplastic_Status: Malignant
Legacy_Concept_Name: Appendix_Mucinous_Adenocarcinoma
has exact synonym: Appendix Mucinous Adenocarcinoma
in subset: oncotree slim

Axiom
annotated source: Appendix Mucinous Adenocarcinoma
annotated property: definition
annotated target: An adenocarcinoma arising from the appendix, characterized by the presence of mucinous stroma formation.
def-source: NCI

Axiom
annotated source: Appendix Mucinous Adenocarcinoma
annotated property: has exact synonym
annotated target: Appendix Mucinous Adenocarcinoma
term-group: PT
term-source: NCI

Ovarian Epithelial Tumor
type: Class
definition: A benign, borderline, or malignant tumor that originates from the surface epithelium of the ovary. It is composed of epithelial cells and stroma. Representative examples of benign tumors include serous cystadenoma, mucinous cystadenoma, and benign Brenner tumor. Representative examples of borderline tumors include serous surface papillary tumor, mucinous adenofibroma, and borderline Brenner tumor. Representative examples of malignant tumors include serous adenocarcinoma, mucinous adenocarcinoma, endometrioid adenocarcinoma, and malignant Brenner tumor.
code: C4381
Semantic_Type: Neoplastic Process
Preferred_Name: Ovarian Epithelial Tumor
UMLS_CUI: C0341823
Neoplastic_Status: Undetermined
Legacy_Concept_Name: Ovarian_Epithelial_Neoplasm
has exact synonym: Epithelial Neoplasm of Ovary
has exact synonym: Epithelial Neoplasm of the Ovary
has exact synonym: Epithelial Tumor of Ovary
has exact synonym: Epithelial Tumor of the Ovary
has exact synonym: Ovarian Epithelial Tumor
has exact synonym: Ovarian Surface Epithelial-Stromal Tumor
has exact synonym: Ovarian Surface-Epithelial Stromal Neoplasm
in subset: oncotree slim

Axiom
annotated source: Ovarian Epithelial Tumor
annotated property: definition
annotated target: A benign, borderline, or malignant tumor that originates from the surface epithelium of the ovary. It is composed of epithelial cells and stroma. Representative examples of benign tumors include serous cystadenoma, mucinous cystadenoma, and benign Brenner tumor. Representative examples of borderline tumors include serous surface papillary tumor, mucinous adenofibroma, and borderline Brenner tumor. Representative examples of malignant tumors include serous adenocarcinoma, mucinous adenocarcinoma, endometrioid adenocarcinoma, and malignant Brenner tumor.
def-source: NCI

Axiom
annotated source: Ovarian Epithelial Tumor
annotated property: has exact synonym
annotated target: Epithelial Neoplasm of Ovary
term-group: SY
term-source: NCI

Axiom
annotated source: Ovarian Epithelial Tumor
annotated property: has exact synonym
annotated target: Epithelial Neoplasm of the Ovary
term-group: SY
term-source: NCI

Axiom
annotated source: Ovarian Epithelial Tumor
annotated property: has exact synonym
annotated target: Epithelial Tumor of Ovary
term-group: SY
term-source: NCI

Axiom
annotated source: Ovarian Epithelial Tumor
annotated property: has exact synonym
annotated target: Epithelial Tumor of the Ovary
term-group: SY
term-source: NCI

Axiom
annotated source: Ovarian Epithelial Tumor
annotated property: has exact synonym
annotated target: Ovarian Epithelial Tumor
term-group: PT
term-source: NCI

Axiom
annotated source: Ovarian Epithelial Tumor
annotated property: has exact synonym
annotated target: Ovarian Surface Epithelial-Stromal Tumor
term-group: SY
term-source: NCI

Axiom
annotated source: Ovarian Epithelial Tumor
annotated property: has exact synonym
annotated target: Ovarian Surface-Epithelial Stromal Neoplasm
term-group: SY
term-source: NCI

Cholangiocarcinoma
type: Class
definition: A carcinoma that arises from the intrahepatic biliary tree (intrahepatic cholangiocarcinoma) or from the junction, or adjacent to the junction, of the right and left hepatic ducts (hilar cholangiocarcinoma). Grossly, the malignant lesions are solid, nodular, and grayish. Morphologically, the vast majority of cases are adenocarcinomas. Signs and symptoms include malaise, weight loss, right upper quadrant abdominal pain, and night sweats. Early detection is difficult and the prognosis is generally poor.
Concept_In_Subset: NCIT C102905
Concept_In_Subset: NCIT C103066
Concept_In_Subset: NCIT C126659
Concept_In_Subset: NCIT C61410
Concept_In_Subset: NCIT C77526
Concept_In_Subset: NCIT C88025
code: C4436
Semantic_Type: Neoplastic Process
Preferred_Name: Cholangiocarcinoma
UMLS_CUI: C0206698
Contributing_Source: CDISC
Contributing_Source: CTEP
ALT_DEFINITION: A malignant neoplasm arising from/comprising cells resembling those of bile ducts.
ALT_DEFINITION: A rare type of cancer that develops in cells that line the bile ducts in the liver. Cancer that forms where the right and left ducts meet is called Klatskin tumor.
ICD-O-3_Code: 8160/3
Neoplastic_Status: Malignant
Legacy_Concept_Name: Cholangiocarcinoma
has exact synonym: CC
has exact synonym: CHOLANGIOCARCINOMA, MALIGNANT
has exact synonym: Cholangiocar.- intra/extrahepatic
has exact synonym: Cholangiocarcinoma
has exact synonym: Cholangiocarcinoma, intrahepatic and extrahepatic bile ducts (adenocarcinoma)
has exact synonym: Cholangiocellular Carcinoma
has exact synonym: cholangiocarcinoma
has exact synonym: cholangiosarcoma
in subset: oncotree slim

Axiom
annotated source: Cholangiocarcinoma
annotated property: definition
annotated target: A carcinoma that arises from the intrahepatic biliary tree (intrahepatic cholangiocarcinoma) or from the junction, or adjacent to the junction, of the right and left hepatic ducts (hilar cholangiocarcinoma). Grossly, the malignant lesions are solid, nodular, and grayish. Morphologically, the vast majority of cases are adenocarcinomas. Signs and symptoms include malaise, weight loss, right upper quadrant abdominal pain, and night sweats. Early detection is difficult and the prognosis is generally poor.
def-source: NCI

Axiom
annotated source: Cholangiocarcinoma
annotated property: ALT_DEFINITION
annotated target: A malignant neoplasm arising from/comprising cells resembling those of bile ducts.
def-source: CDISC

Axiom
annotated source: Cholangiocarcinoma
annotated property: ALT_DEFINITION
annotated target: A rare type of cancer that develops in cells that line the bile ducts in the liver. Cancer that forms where the right and left ducts meet is called Klatskin tumor.
def-source: NCI-GLOSS

Axiom
annotated source: Cholangiocarcinoma
annotated property: has exact synonym
annotated target: CC
term-group: AB
term-source: NCI

Axiom
annotated source: Cholangiocarcinoma
annotated property: has exact synonym
annotated target: CHOLANGIOCARCINOMA, MALIGNANT
term-group: PT
term-source: CDISC

Axiom
annotated source: Cholangiocarcinoma
annotated property: has exact synonym
annotated target: Cholangiocar.- intra/extrahepatic
term-group: SY
term-source: CTEP
source-code: 10004669
subsource-name: SDC

Axiom
annotated source: Cholangiocarcinoma
annotated property: has exact synonym
annotated target: Cholangiocarcinoma
term-group: PT
term-source: CTRP

Axiom
annotated source: Cholangiocarcinoma
annotated property: has exact synonym
annotated target: Cholangiocarcinoma
term-group: PT
term-source: NCI

Axiom
annotated source: Cholangiocarcinoma
annotated property: has exact synonym
annotated target: Cholangiocarcinoma
term-group: SY
term-source: NCI
source-code: TCGA
subsource-name: caDSR

Axiom
annotated source: Cholangiocarcinoma
annotated property: has exact synonym
annotated target: Cholangiocarcinoma, intrahepatic and extrahepatic bile ducts (adenocarcinoma)
term-group: PT
term-source: CTEP
source-code: 10004669
subsource-name: SDC

Axiom
annotated source: Cholangiocarcinoma
annotated property: has exact synonym
annotated target: Cholangiocellular Carcinoma
term-group: AQS
term-source: NCI

Axiom
annotated source: Cholangiocarcinoma
annotated property: has exact synonym
annotated target: Cholangiocellular Carcinoma
term-group: SY
term-source: CDISC

Axiom
annotated source: Cholangiocarcinoma
annotated property: has exact synonym
annotated target: cholangiocarcinoma
term-group: PT
term-source: NCI-GLOSS
source-code: CDR0000335064

Axiom
annotated source: Cholangiocarcinoma
annotated property: has exact synonym
annotated target: cholangiosarcoma
term-group: PT
term-source: NCI-GLOSS
source-code: CDR0000046473

Liver Angiosarcoma
type: Class
definition: A malignant vascular neoplasm arising from the liver.
code: C4438
Semantic_Type: Neoplastic Process
Preferred_Name: Liver Angiosarcoma
UMLS_CUI: C0345907
ICD-O-3_Code: 9124/3
Neoplastic_Status: Malignant
Legacy_Concept_Name: Hepatic_Angiosarcoma
has exact synonym: Angiosarcoma of Liver
has exact synonym: Angiosarcoma of the Liver
has exact synonym: Hemangiosarcoma of Liver
has exact synonym: Hemangiosarcoma of the Liver
has exact synonym: Hepatic Angiosarcoma
has exact synonym: Hepatic Hemangiosarcoma
has exact synonym: Liver Angiosarcoma
has exact synonym: Liver Hemangiosarcoma
has exact synonym: Primary Angiosarcoma of Liver
has exact synonym: Primary Angiosarcoma of the Liver
in subset: oncotree slim

Axiom
annotated source: Liver Angiosarcoma
annotated property: definition
annotated target: A malignant vascular neoplasm arising from the liver.
def-source: NCI

Axiom
annotated source: Liver Angiosarcoma
annotated property: has exact synonym
annotated target: Angiosarcoma of Liver
term-group: SY
term-source: NCI

Axiom
annotated source: Liver Angiosarcoma
annotated property: has exact synonym
annotated target: Angiosarcoma of the Liver
term-group: SY
term-source: NCI

Axiom
annotated source: Liver Angiosarcoma
annotated property: has exact synonym
annotated target: Hemangiosarcoma of Liver
term-group: SY
term-source: NCI

Axiom
annotated source: Liver Angiosarcoma
annotated property: has exact synonym
annotated target: Hemangiosarcoma of the Liver
term-group: SY
term-source: NCI

Axiom
annotated source: Liver Angiosarcoma
annotated property: has exact synonym
annotated target: Hepatic Angiosarcoma
term-group: SY
term-source: NCI

Axiom
annotated source: Liver Angiosarcoma
annotated property: has exact synonym
annotated target: Hepatic Hemangiosarcoma
term-group: SY
term-source: NCI

Axiom
annotated source: Liver Angiosarcoma
annotated property: has exact synonym
annotated target: Liver Angiosarcoma
term-group: PT
term-source: NCI

Axiom
annotated source: Liver Angiosarcoma
annotated property: has exact synonym
annotated target: Liver Hemangiosarcoma
term-group: SY
term-source: NCI

Axiom
annotated source: Liver Angiosarcoma
annotated property: has exact synonym
annotated target: Primary Angiosarcoma of Liver
term-group: SY
term-source: NCI

Axiom
annotated source: Liver Angiosarcoma
annotated property: has exact synonym
annotated target: Primary Angiosarcoma of the Liver
term-group: SY
term-source: NCI

Large Cell Lung Carcinoma
type: Class
subclass of: Non-Small Cell Lung Carcinoma
definition: A poorly differentiated non-small cell lung carcinoma composed of large polygonal cells without evidence of glandular or squamous differentiation. There is a male predilection.
Concept_In_Subset: NCIT C116977
Concept_In_Subset: NCIT C126659
code: C4450
Semantic_Type: Neoplastic Process
Display_Name: Large Cell Lung Cancer
Preferred_Name: Large Cell Lung Carcinoma
UMLS_CUI: C0345958
Contributing_Source: CTRP
Neoplastic_Status: Malignant
Legacy_Concept_Name: Large_Cell_Lung_Carcinoma
has exact synonym: Anaplastic Lung Carcinoma
has exact synonym: Large Cell Carcinoma of Lung
has exact synonym: Large Cell Carcinoma of the Lung
has exact synonym: Large Cell Lung Cancer
has exact synonym: Large Cell Lung Carcinoma
has exact synonym: Large Cell Undifferentiated Lung Carcinoma
in subset: oncotree slim

Axiom
annotated source: Large Cell Lung Carcinoma
annotated property: definition
annotated target: A poorly differentiated non-small cell lung carcinoma composed of large polygonal cells without evidence of glandular or squamous differentiation. There is a male predilection.
def-source: NCI

Axiom
annotated source: Large Cell Lung Carcinoma
annotated property: has exact synonym
annotated target: Anaplastic Lung Carcinoma
term-group: SY
term-source: NCI

Axiom
annotated source: Large Cell Lung Carcinoma
annotated property: has exact synonym
annotated target: Large Cell Carcinoma of Lung
term-group: SY
term-source: NCI

Axiom
annotated source: Large Cell Lung Carcinoma
annotated property: has exact synonym
annotated target: Large Cell Carcinoma of the Lung
term-group: SY
term-source: NCI

Axiom
annotated source: Large Cell Lung Carcinoma
annotated property: has exact synonym
annotated target: Large Cell Lung Cancer
term-group: DN
term-source: CTRP

Axiom
annotated source: Large Cell Lung Carcinoma
annotated property: has exact synonym
annotated target: Large Cell Lung Carcinoma
term-group: PT
term-source: NCI

Axiom
annotated source: Large Cell Lung Carcinoma
annotated property: has exact synonym
annotated target: Large Cell Undifferentiated Lung Carcinoma
term-group: SY
term-source: NCI

Large Cell Lung Carcinoma, Clear Cell Variant
type: Class
subclass of: Large Cell Lung Carcinoma
definition: A morphologic variant of large cell lung carcinoma characterized by a predominance of clear cells that may or may not contain glycogen.
Concept_In_Subset: NCIT C126659
code: C4451
Semantic_Type: Neoplastic Process
Preferred_Name: Large Cell Lung Carcinoma, Clear Cell Variant
UMLS_CUI: C1707407
Neoplastic_Status: Malignant
Legacy_Concept_Name: Clear_Cell_Lung_Carcinoma
has exact synonym: Clear Cell Carcinoma of Lung, Large Cell Type
has exact synonym: Clear Cell Carcinoma of the Lung, Large Cell Type
has exact synonym: Clear Cell Lung Carcinoma, Large Cell Type
has exact synonym: Large Cell Lung Carcinoma, Clear Cell Variant
in subset: oncotree slim

Axiom
annotated source: Large Cell Lung Carcinoma, Clear Cell Variant
annotated property: definition
annotated target: A morphologic variant of large cell lung carcinoma characterized by a predominance of clear cells that may or may not contain glycogen.
def-source: NCI

Axiom
annotated source: Large Cell Lung Carcinoma, Clear Cell Variant
annotated property: has exact synonym
annotated target: Clear Cell Carcinoma of Lung, Large Cell Type
term-group: SY
term-source: NCI

Axiom
annotated source: Large Cell Lung Carcinoma, Clear Cell Variant
annotated property: has exact synonym
annotated target: Clear Cell Carcinoma of the Lung, Large Cell Type
term-group: SY
term-source: NCI

Axiom
annotated source: Large Cell Lung Carcinoma, Clear Cell Variant
annotated property: has exact synonym
annotated target: Clear Cell Lung Carcinoma, Large Cell Type
term-group: SY
term-source: NCI

Axiom
annotated source: Large Cell Lung Carcinoma, Clear Cell Variant
annotated property: has exact synonym
annotated target: Large Cell Lung Carcinoma, Clear Cell Variant
term-group: PT
term-source: NCI

Lung Giant Cell Carcinoma
type: Class
subclass of: Lung Sarcomatoid Carcinoma
definition: A morphologic variant of lung sarcomatoid carcinoma characterized by the presence of mononuclear and multinucleated pleomorphic neoplastic giant cells that lack cohesion.
Concept_In_Subset: NCIT C126659
code: C4452
Semantic_Type: Neoplastic Process
Preferred_Name: Lung Giant Cell Carcinoma
UMLS_CUI: C0345960
Neoplastic_Status: Malignant
Legacy_Concept_Name: Giant_Cell_Lung_Carcinoma
has exact synonym: Giant Cell Carcinoma of Lung
has exact synonym: Giant Cell Carcinoma of the Lung
has exact synonym: Lung Giant Cell Carcinoma
in subset: oncotree slim

Axiom
annotated source: Lung Giant Cell Carcinoma
annotated property: definition
annotated target: A morphologic variant of lung sarcomatoid carcinoma characterized by the presence of mononuclear and multinucleated pleomorphic neoplastic giant cells that lack cohesion.
def-source: NCI

Axiom
annotated source: Lung Giant Cell Carcinoma
annotated property: has exact synonym
annotated target: Giant Cell Carcinoma of Lung
term-group: SY
term-source: NCI

Axiom
annotated source: Lung Giant Cell Carcinoma
annotated property: has exact synonym
annotated target: Giant Cell Carcinoma of the Lung
term-group: SY
term-source: NCI

Axiom
annotated source: Lung Giant Cell Carcinoma
annotated property: has exact synonym
annotated target: Lung Giant Cell Carcinoma
term-group: PT
term-source: NCI

Malignant Breast Phyllodes Tumor
type: Class
subclass of: Breast Phyllodes Tumor
definition: A phyllodes tumor of the breast characterized by infiltrative margins and a sarcomatous stromal component. The sarcomatous stroma usually displays features of fibrosarcoma. Liposarcomatous, osteosarcomatous, or rhabdomyosarcomatous elements may also be present.
Concept_In_Subset: NCIT C126659
code: C4504
Semantic_Type: Neoplastic Process
Preferred_Name: Malignant Breast Phyllodes Tumor
UMLS_CUI: C0346154
Neoplastic_Status: Malignant
Legacy_Concept_Name: Malignant_Phyllodes_Breast_Tumor
has exact synonym: Malignant Breast Phyllodes Neoplasm
has exact synonym: Malignant Breast Phyllodes Tumor
has exact synonym: Malignant Cystosarcoma Phyllodes of Breast
has exact synonym: Malignant Cystosarcoma Phyllodes of the Breast
has exact synonym: Malignant Mammary Phyllodes Neoplasm
has exact synonym: Malignant Mammary Phyllodes Tumor
has exact synonym: Malignant Phyllodes Breast Neoplasm
has exact synonym: Malignant Phyllodes Neoplasm of Breast
has exact synonym: Malignant Phyllodes Neoplasm of the Breast
has exact synonym: Malignant Phyllodes Tumor of Breast
has exact synonym: Malignant Phyllodes Tumor of the Breast
in subset: oncotree slim

Axiom
annotated source: Malignant Breast Phyllodes Tumor
annotated property: definition
annotated target: A phyllodes tumor of the breast characterized by infiltrative margins and a sarcomatous stromal component. The sarcomatous stroma usually displays features of fibrosarcoma. Liposarcomatous, osteosarcomatous, or rhabdomyosarcomatous elements may also be present.
def-source: NCI

Axiom
annotated source: Malignant Breast Phyllodes Tumor
annotated property: has exact synonym
annotated target: Malignant Breast Phyllodes Neoplasm
term-group: SY
term-source: NCI

Axiom
annotated source: Malignant Breast Phyllodes Tumor
annotated property: has exact synonym
annotated target: Malignant Breast Phyllodes Tumor
term-group: PT
term-source: NCI

Axiom
annotated source: Malignant Breast Phyllodes Tumor
annotated property: has exact synonym
annotated target: Malignant Cystosarcoma Phyllodes of Breast
term-group: SY
term-source: NCI

Axiom
annotated source: Malignant Breast Phyllodes Tumor
annotated property: has exact synonym
annotated target: Malignant Cystosarcoma Phyllodes of the Breast
term-group: SY
term-source: NCI

Axiom
annotated source: Malignant Breast Phyllodes Tumor
annotated property: has exact synonym
annotated target: Malignant Mammary Phyllodes Neoplasm
term-group: SY
term-source: NCI

Axiom
annotated source: Malignant Breast Phyllodes Tumor
annotated property: has exact synonym
annotated target: Malignant Mammary Phyllodes Tumor
term-group: SY
term-source: NCI

Axiom
annotated source: Malignant Breast Phyllodes Tumor
annotated property: has exact synonym
annotated target: Malignant Phyllodes Breast Neoplasm
term-group: SY
term-source: NCI

Axiom
annotated source: Malignant Breast Phyllodes Tumor
annotated property: has exact synonym
annotated target: Malignant Phyllodes Neoplasm of Breast
term-group: SY
term-source: NCI

Axiom
annotated source: Malignant Breast Phyllodes Tumor
annotated property: has exact synonym
annotated target: Malignant Phyllodes Neoplasm of the Breast
term-group: SY
term-source: NCI

Axiom
annotated source: Malignant Breast Phyllodes Tumor
annotated property: has exact synonym
annotated target: Malignant Phyllodes Tumor of Breast
term-group: SY
term-source: NCI

Axiom
annotated source: Malignant Breast Phyllodes Tumor
annotated property: has exact synonym
annotated target: Malignant Phyllodes Tumor of the Breast
term-group: SY
term-source: NCI

Cervical Adenosquamous Carcinoma
type: Class
definition: An uncommon carcinoma arising from the cervix. It is composed of malignant glandular epithelial cells and malignant squamous epithelial cells.
Concept_In_Subset: NCIT C116977
Concept_In_Subset: NCIT C126659
code: C4519
Semantic_Type: Neoplastic Process
Display_Name: Cervical Adenosquamous Cancer
Preferred_Name: Cervical Adenosquamous Carcinoma
UMLS_CUI: C0346202
Contributing_Source: CTRP
Neoplastic_Status: Malignant
Legacy_Concept_Name: Cervical_Adenosquamous_Carcinoma
has exact synonym: Adenosquamous Cell Carcinoma of Cervix
has exact synonym: Adenosquamous Cell Carcinoma of Cervix Uteri
has exact synonym: Adenosquamous Cell Carcinoma of Uterine Cervix
has exact synonym: Adenosquamous Cell Carcinoma of the Cervix
has exact synonym: Adenosquamous Cell Carcinoma of the Cervix Uteri
has exact synonym: Adenosquamous Cell Carcinoma of the Uterine Cervix
has exact synonym: Cervical Adenosquamous Cancer
has exact synonym: Cervical Adenosquamous Carcinoma
has exact synonym: Cervical Adenosquamous Cell Carcinoma
has exact synonym: Cervix Adenosquamous Cell Carcinoma
has exact synonym: Cervix Uteri Adenosquamous Cell Carcinoma
has exact synonym: Uterine Cervix Adenosquamous Cell Carcinoma
in subset: oncotree slim

Axiom
annotated source: Cervical Adenosquamous Carcinoma
annotated property: definition
annotated target: An uncommon carcinoma arising from the cervix. It is composed of malignant glandular epithelial cells and malignant squamous epithelial cells.
def-source: NCI

Axiom
annotated source: Cervical Adenosquamous Carcinoma
annotated property: has exact synonym
annotated target: Adenosquamous Cell Carcinoma of Cervix
term-group: SY
term-source: NCI

Axiom
annotated source: Cervical Adenosquamous Carcinoma
annotated property: has exact synonym
annotated target: Adenosquamous Cell Carcinoma of Cervix Uteri
term-group: SY
term-source: NCI

Axiom
annotated source: Cervical Adenosquamous Carcinoma
annotated property: has exact synonym
annotated target: Adenosquamous Cell Carcinoma of Uterine Cervix
term-group: SY
term-source: NCI

Axiom
annotated source: Cervical Adenosquamous Carcinoma
annotated property: has exact synonym
annotated target: Adenosquamous Cell Carcinoma of the Cervix
term-group: SY
term-source: NCI

Axiom
annotated source: Cervical Adenosquamous Carcinoma
annotated property: has exact synonym
annotated target: Adenosquamous Cell Carcinoma of the Cervix Uteri
term-group: SY
term-source: NCI

Axiom
annotated source: Cervical Adenosquamous Carcinoma
annotated property: has exact synonym
annotated target: Adenosquamous Cell Carcinoma of the Uterine Cervix
term-group: SY
term-source: NCI

Axiom
annotated source: Cervical Adenosquamous Carcinoma
annotated property: has exact synonym
annotated target: Cervical Adenosquamous Cancer
term-group: DN
term-source: CTRP

Axiom
annotated source: Cervical Adenosquamous Carcinoma
annotated property: has exact synonym
annotated target: Cervical Adenosquamous Carcinoma
term-group: PT
term-source: NCI

Axiom
annotated source: Cervical Adenosquamous Carcinoma
annotated property: has exact synonym
annotated target: Cervical Adenosquamous Cell Carcinoma
term-group: SY
term-source: NCI

Axiom
annotated source: Cervical Adenosquamous Carcinoma
annotated property: has exact synonym
annotated target: Cervix Adenosquamous Cell Carcinoma
term-group: SY
term-source: NCI

Axiom
annotated source: Cervical Adenosquamous Carcinoma
annotated property: has exact synonym
annotated target: Cervix Uteri Adenosquamous Cell Carcinoma
term-group: SY
term-source: NCI

Axiom
annotated source: Cervical Adenosquamous Carcinoma
annotated property: has exact synonym
annotated target: Uterine Cervix Adenosquamous Cell Carcinoma
term-group: SY
term-source: NCI

Low Grade Fibromyxoid Sarcoma
type: Class
definition: A low grade, late-metastasizing variant of fibrosarcoma characterized by alternating fibrous and myxoid areas and a whorling growth pattern. The neoplastic cells have a spindle morphology, and lack hyperchromasia or significant nuclear atypia. Approximately 40% of cases show the focal presence of collagen rosettes. A t(7;16)(q33;p11) translocation has been identified in the majority of cases, associated with the presence of FUS-CREB3L2 fusion protein. Rare cases carry the t(11;16)(p11;p11) translocation which is associated with the presence of the FUS-CREB3L1 fusion protein.
code: C45202
Semantic_Type: Neoplastic Process
Preferred_Name: Low Grade Fibromyxoid Sarcoma
UMLS_CUI: C1275282
Neoplastic_Status: Malignant
Legacy_Concept_Name: Low_Grade_Fibromyxoid_Sarcoma
has exact synonym: Low Grade Fibromyxoid Sarcoma
in subset: oncotree slim

Axiom
annotated source: Low Grade Fibromyxoid Sarcoma
annotated property: definition
annotated target: A low grade, late-metastasizing variant of fibrosarcoma characterized by alternating fibrous and myxoid areas and a whorling growth pattern. The neoplastic cells have a spindle morphology, and lack hyperchromasia or significant nuclear atypia. Approximately 40% of cases show the focal presence of collagen rosettes. A t(7;16)(q33;p11) translocation has been identified in the majority of cases, associated with the presence of FUS-CREB3L2 fusion protein. Rare cases carry the t(11;16)(p11;p11) translocation which is associated with the presence of the FUS-CREB3L1 fusion protein.
def-source: NCI

Axiom
annotated source: Low Grade Fibromyxoid Sarcoma
annotated property: has exact synonym
annotated target: Low Grade Fibromyxoid Sarcoma
term-group: PT
term-source: NCI

Kidney Oncocytoma
type: Class
definition: A benign tumor of the kidney, characterized by the presence of large cells with abundant eosinophilic granular cytoplasm. The majority of these tumors are discovered incidentally, during work-up of other conditions.
Concept_In_Subset: NCIT C126659
code: C4526
Semantic_Type: Neoplastic Process
Preferred_Name: Kidney Oncocytoma
UMLS_CUI: C0346255
Neoplastic_Status: Benign
Legacy_Concept_Name: Renal_Oncocytoma
has exact synonym: Kidney Oncocytoma
has exact synonym: Oncocytoma of Kidney
has exact synonym: Oncocytoma of the Kidney
has exact synonym: Renal Epithelial Oncocytic Neoplasm
has exact synonym: Renal Epithelial Oncocytic Tumor
has exact synonym: Renal Oncocytoma
in subset: oncotree slim

Axiom
annotated source: Kidney Oncocytoma
annotated property: definition
annotated target: A benign tumor of the kidney, characterized by the presence of large cells with abundant eosinophilic granular cytoplasm. The majority of these tumors are discovered incidentally, during work-up of other conditions.
def-source: NCI

Axiom
annotated source: Kidney Oncocytoma
annotated property: has exact synonym
annotated target: Kidney Oncocytoma
term-group: PT
term-source: NCI

Axiom
annotated source: Kidney Oncocytoma
annotated property: has exact synonym
annotated target: Oncocytoma of Kidney
term-group: SY
term-source: NCI

Axiom
annotated source: Kidney Oncocytoma
annotated property: has exact synonym
annotated target: Oncocytoma of the Kidney
term-group: SY
term-source: NCI

Axiom
annotated source: Kidney Oncocytoma
annotated property: has exact synonym
annotated target: Renal Epithelial Oncocytic Neoplasm
term-group: SY
term-source: NCI

Axiom
annotated source: Kidney Oncocytoma
annotated property: has exact synonym
annotated target: Renal Epithelial Oncocytic Tumor
term-group: SY
term-source: NCI

Axiom
annotated source: Kidney Oncocytoma
annotated property: has exact synonym
annotated target: Renal Oncocytoma
term-group: SY
term-source: NCI

Pituitary Gland Carcinoma
type: Class
definition: A rare adenocarcinoma with poor prognosis, arising from the adenohypophysial cells of the anterior lobe of the pituitary gland or pre-existing adenomas. The majority are hormonally functioning neoplasms, usually producing prolactin or ACTH. The diagnosis is based on the presence of metastases. Syndromes associated with pituitary gland carcinomas include hyperprolactinemia, Cushing disease, and acromegaly.
Concept_In_Subset: NCIT C102905
Concept_In_Subset: NCIT C103051
Concept_In_Subset: NCIT C126659
code: C4536
Semantic_Type: Neoplastic Process
Preferred_Name: Pituitary Gland Carcinoma
UMLS_CUI: C0346300
Contributing_Source: CTEP
ICD-O-3_Code: 8272/3
Neoplastic_Status: Malignant
Legacy_Concept_Name: Pituitary_Gland_Carcinoma
has exact synonym: Cancer of Pituitary
has exact synonym: Cancer of Pituitary Gland
has exact synonym: Cancer of the Pituitary
has exact synonym: Cancer of the Pituitary Gland
has exact synonym: Carcinoma of Pituitary
has exact synonym: Carcinoma of Pituitary Gland
has exact synonym: Carcinoma of the Pituitary
has exact synonym: Carcinoma of the Pituitary Gland
has exact synonym: Pituitary Carcinoma
has exact synonym: Pituitary Gland Adenocarcinoma
has exact synonym: Pituitary Gland Cancer
has exact synonym: Pituitary Gland Carcinoma
has exact synonym: Pituitary gland cancer, NOS
in subset: oncotree slim

Axiom
annotated source: Pituitary Gland Carcinoma
annotated property: definition
annotated target: A rare adenocarcinoma with poor prognosis, arising from the adenohypophysial cells of the anterior lobe of the pituitary gland or pre-existing adenomas. The majority are hormonally functioning neoplasms, usually producing prolactin or ACTH. The diagnosis is based on the presence of metastases. Syndromes associated with pituitary gland carcinomas include hyperprolactinemia, Cushing disease, and acromegaly.
def-source: NCI

Axiom
annotated source: Pituitary Gland Carcinoma
annotated property: has exact synonym
annotated target: Cancer of Pituitary
term-group: SY
term-source: NCI

Axiom
annotated source: Pituitary Gland Carcinoma
annotated property: has exact synonym
annotated target: Cancer of Pituitary Gland
term-group: SY
term-source: NCI

Axiom
annotated source: Pituitary Gland Carcinoma
annotated property: has exact synonym
annotated target: Cancer of the Pituitary
term-group: SY
term-source: NCI

Axiom
annotated source: Pituitary Gland Carcinoma
annotated property: has exact synonym
annotated target: Cancer of the Pituitary Gland
term-group: SY
term-source: NCI

Axiom
annotated source: Pituitary Gland Carcinoma
annotated property: has exact synonym
annotated target: Carcinoma of Pituitary
term-group: SY
term-source: NCI

Axiom
annotated source: Pituitary Gland Carcinoma
annotated property: has exact synonym
annotated target: Carcinoma of Pituitary Gland
term-group: SY
term-source: NCI

Axiom
annotated source: Pituitary Gland Carcinoma
annotated property: has exact synonym
annotated target: Carcinoma of the Pituitary
term-group: SY
term-source: NCI

Axiom
annotated source: Pituitary Gland Carcinoma
annotated property: has exact synonym
annotated target: Carcinoma of the Pituitary Gland
term-group: SY
term-source: NCI

Axiom
annotated source: Pituitary Gland Carcinoma
annotated property: has exact synonym
annotated target: Pituitary Carcinoma
term-group: SY
term-source: NCI

Axiom
annotated source: Pituitary Gland Carcinoma
annotated property: has exact synonym
annotated target: Pituitary Gland Adenocarcinoma
term-group: SY
term-source: NCI

Axiom
annotated source: Pituitary Gland Carcinoma
annotated property: has exact synonym
annotated target: Pituitary Gland Cancer
term-group: DN
term-source: CTRP

Axiom
annotated source: Pituitary Gland Carcinoma
annotated property: has exact synonym
annotated target: Pituitary Gland Cancer
term-group: SY
term-source: NCI

Axiom
annotated source: Pituitary Gland Carcinoma
annotated property: has exact synonym
annotated target: Pituitary Gland Carcinoma
term-group: PT
term-source: CTRP

Axiom
annotated source: Pituitary Gland Carcinoma
annotated property: has exact synonym
annotated target: Pituitary Gland Carcinoma
term-group: PT
term-source: NCI

Axiom
annotated source: Pituitary Gland Carcinoma
annotated property: has exact synonym
annotated target: Pituitary gland cancer, NOS
term-group: PT
term-source: CTEP
source-code: 10035106
subsource-name: SDC

Conjunctival Melanoma
type: Class
subclass of: NCIT C8562
definition: A malignant melanoma within the conjunctiva of the eye.
Concept_In_Subset: NCIT C116977
code: C4550
Semantic_Type: Neoplastic Process
Display_Name: Conjunctival Melanoma
Preferred_Name: Conjunctival Melanoma
UMLS_CUI: C0346360
Contributing_Source: CTRP
Neoplastic_Status: Malignant
Legacy_Concept_Name: Conjunctival_Melanoma
has exact synonym: Conjunctiva Melanoma
has exact synonym: Conjunctival Melanoma
has exact synonym: Malignant Conjunctiva Melanoma
has exact synonym: Malignant Conjunctival Melanoma
has exact synonym: Malignant Melanoma of Conjunctiva
has exact synonym: Malignant Melanoma of the Conjunctiva
has exact synonym: Melanoma of Conjunctiva
has exact synonym: Melanoma of the Conjunctiva
in subset: oncotree slim

Axiom
annotated source: Conjunctival Melanoma
annotated property: definition
annotated target: A malignant melanoma within the conjunctiva of the eye.
def-source: NCI

Axiom
annotated source: Conjunctival Melanoma
annotated property: has exact synonym
annotated target: Conjunctiva Melanoma
term-group: SY
term-source: NCI

Axiom
annotated source: Conjunctival Melanoma
annotated property: has exact synonym
annotated target: Conjunctival Melanoma
term-group: PT
term-source: NCI

Axiom
annotated source: Conjunctival Melanoma
annotated property: has exact synonym
annotated target: Malignant Conjunctiva Melanoma
term-group: SY
term-source: NCI

Axiom
annotated source: Conjunctival Melanoma
annotated property: has exact synonym
annotated target: Malignant Conjunctival Melanoma
term-group: SY
term-source: NCI

Axiom
annotated source: Conjunctival Melanoma
annotated property: has exact synonym
annotated target: Malignant Melanoma of Conjunctiva
term-group: SY
term-source: NCI

Axiom
annotated source: Conjunctival Melanoma
annotated property: has exact synonym
annotated target: Malignant Melanoma of the Conjunctiva
term-group: SY
term-source: NCI

Axiom
annotated source: Conjunctival Melanoma
annotated property: has exact synonym
annotated target: Melanoma of Conjunctiva
term-group: SY
term-source: NCI

Axiom
annotated source: Conjunctival Melanoma
annotated property: has exact synonym
annotated target: Melanoma of the Conjunctiva
term-group: SY
term-source: NCI

Lymphoepithelioma-Like Lung Carcinoma
type: Class
subclass of: Large Cell Lung Carcinoma
definition: A morphologic variant of large cell lung carcinoma characterized by the presence of a syncytial growth pattern, large vesicular nuclei with esophnophilic nucleoi, and dense lymphoplasmacytic infiltration.
Concept_In_Subset: NCIT C126659
code: C45519
Semantic_Type: Neoplastic Process
Preferred_Name: Lymphoepithelioma-Like Lung Carcinoma
UMLS_CUI: C1708792
Neoplastic_Status: Malignant
Legacy_Concept_Name: Lymphoepithelioma-Like_Lung_Carcinoma
has exact synonym: Lymphoepithelioma-Like Lung Carcinoma
in subset: oncotree slim

Axiom
annotated source: Lymphoepithelioma-Like Lung Carcinoma
annotated property: definition
annotated target: A morphologic variant of large cell lung carcinoma characterized by the presence of a syncytial growth pattern, large vesicular nuclei with esophnophilic nucleoi, and dense lymphoplasmacytic infiltration.
def-source: NCI

Axiom
annotated source: Lymphoepithelioma-Like Lung Carcinoma
annotated property: has exact synonym
annotated target: Lymphoepithelioma-Like Lung Carcinoma
term-group: PT
term-source: NCI

Lung Sarcomatoid Carcinoma
type: Class
subclass of: Non-Small Cell Lung Carcinoma
definition: A rare, aggressive, poorly differentiated, non-small cell lung carcinoma characterized by the presence of a sarcomatoid component often associated with giant cell differentiation. There is a male to female ratio of 4:1. Clinical symptoms include cough, hemoptysis, chest pain, progressive dyspnea and fever secondary to recurrent pneumonia. Cigarette smoking is a major risk factor.
Concept_In_Subset: NCIT C126659
code: C45540
Semantic_Type: Neoplastic Process
Preferred_Name: Lung Sarcomatoid Carcinoma
UMLS_CUI: C1708781
Neoplastic_Status: Malignant
Legacy_Concept_Name: Lung_Sarcomatoid_Carcinoma
has exact synonym: Lung Sarcomatoid Carcinoma
in subset: oncotree slim

Axiom
annotated source: Lung Sarcomatoid Carcinoma
annotated property: definition
annotated target: A rare, aggressive, poorly differentiated, non-small cell lung carcinoma characterized by the presence of a sarcomatoid component often associated with giant cell differentiation. There is a male to female ratio of 4:1. Clinical symptoms include cough, hemoptysis, chest pain, progressive dyspnea and fever secondary to recurrent pneumonia. Cigarette smoking is a major risk factor.
def-source: NCI

Axiom
annotated source: Lung Sarcomatoid Carcinoma
annotated property: has exact synonym
annotated target: Lung Sarcomatoid Carcinoma
term-group: PT
term-source: NCI

Lung Mucoepidermoid Carcinoma
type: Class
subclass of: Mucoepidermoid Carcinoma
definition: A lung carcinoma characterized by the presence of malignant non-keratinizing squamoid cells, mucin-producing cells and intermediate type cells.
Concept_In_Subset: NCIT C126659
code: C45544
Semantic_Type: Neoplastic Process
Preferred_Name: Lung Mucoepidermoid Carcinoma
UMLS_CUI: C1708778
Neoplastic_Status: Malignant
Legacy_Concept_Name: Lung_Mucoepidermoid_Carcinoma
has exact synonym: Lung Mucoepidermoid Cancer
has exact synonym: Lung Mucoepidermoid Carcinoma
in subset: oncotree slim

Axiom
annotated source: Lung Mucoepidermoid Carcinoma
annotated property: definition
annotated target: A lung carcinoma characterized by the presence of malignant non-keratinizing squamoid cells, mucin-producing cells and intermediate type cells.
def-source: NCI

Axiom
annotated source: Lung Mucoepidermoid Carcinoma
annotated property: has exact synonym
annotated target: Lung Mucoepidermoid Cancer
term-group: DN
term-source: CTRP

Axiom
annotated source: Lung Mucoepidermoid Carcinoma
annotated property: has exact synonym
annotated target: Lung Mucoepidermoid Carcinoma
term-group: PT
term-source: NCI

Lung Atypical Carcinoid Tumor
type: Class
subclass of: Lung Carcinoid Tumor
definition: A carcinoid tumor of the lung showing focal necrotic changes or a number of mitotic figures between 2 and 10/10 high power fields.
code: C45551
Semantic_Type: Neoplastic Process
Preferred_Name: Lung Atypical Carcinoid Tumor
UMLS_CUI: C1708766
ICD-O-3_Code: 8249/3
Neoplastic_Status: Malignant
Legacy_Concept_Name: Lung_Atypical_Carcinoid_Tumor
has exact synonym: Lung Atypical Carcinoid Tumor
has exact synonym: Lung Malignant Carcinoid Tumor
in subset: oncotree slim

Axiom
annotated source: Lung Atypical Carcinoid Tumor
annotated property: definition
annotated target: A carcinoid tumor of the lung showing focal necrotic changes or a number of mitotic figures between 2 and 10/10 high power fields.
def-source: NCI

Axiom
annotated source: Lung Atypical Carcinoid Tumor
annotated property: has exact synonym
annotated target: Lung Atypical Carcinoid Tumor
term-group: PT
term-source: NCI

Axiom
annotated source: Lung Atypical Carcinoid Tumor
annotated property: has exact synonym
annotated target: Lung Malignant Carcinoid Tumor
term-group: SY
term-source: NCI

Pleural Epithelioid Mesothelioma
type: Class
definition: Malignant mesothelioma that arises from the pleura and is characterized by the presence of cells with epithelioid morphology. The epithelioid cells usually have eosinophilic cytoplasm, bland nuclei, and form tubulopapillary, microglandular, or sheet-like patterns.
code: C45662
Semantic_Type: Neoplastic Process
Preferred_Name: Pleural Epithelioid Mesothelioma
UMLS_CUI: C1709574
Neoplastic_Status: Malignant
Legacy_Concept_Name: Pleural_Epithelioid_Mesothelioma
has exact synonym: Pleural Epithelioid Mesothelioma
in subset: oncotree slim

Axiom
annotated source: Pleural Epithelioid Mesothelioma
annotated property: definition
annotated target: Malignant mesothelioma that arises from the pleura and is characterized by the presence of cells with epithelioid morphology. The epithelioid cells usually have eosinophilic cytoplasm, bland nuclei, and form tubulopapillary, microglandular, or sheet-like patterns.
def-source: NCI

Axiom
annotated source: Pleural Epithelioid Mesothelioma
annotated property: has exact synonym
annotated target: Pleural Epithelioid Mesothelioma
term-group: PT
term-source: NCI

Pleural Sarcomatoid Mesothelioma
type: Class
definition: Malignant mesothelioma that arises from the pleura and is characterized by the presence of spindle-shaped cells forming fascicles, or that are distributed haphazardly resembling a sarcoma.
code: C45663
Semantic_Type: Neoplastic Process
Preferred_Name: Pleural Sarcomatoid Mesothelioma
UMLS_CUI: C1709578
Neoplastic_Status: Malignant
Legacy_Concept_Name: Pleural_Sarcomatoid_Mesothelioma
has exact synonym: Pleural Sarcomatoid Mesothelioma
in subset: oncotree slim

Axiom
annotated source: Pleural Sarcomatoid Mesothelioma
annotated property: definition
annotated target: Malignant mesothelioma that arises from the pleura and is characterized by the presence of spindle-shaped cells forming fascicles, or that are distributed haphazardly resembling a sarcoma.
def-source: NCI

Axiom
annotated source: Pleural Sarcomatoid Mesothelioma
annotated property: has exact synonym
annotated target: Pleural Sarcomatoid Mesothelioma
term-group: PT
term-source: NCI

Pleural Biphasic Mesothelioma
type: Class
definition: Malignant mesothelioma that arises from the pleura. It is characterized by the presence of epithelioid and sarcomatoid components, with each component representing at least 10% of the tumor.
code: C45665
Semantic_Type: Neoplastic Process
Preferred_Name: Pleural Biphasic Mesothelioma
UMLS_CUI: C1709570
Neoplastic_Status: Malignant
Legacy_Concept_Name: Pleural_Biphasic_Mesothelioma
has exact synonym: Pleural Biphasic Mesothelioma
in subset: oncotree slim

Axiom
annotated source: Pleural Biphasic Mesothelioma
annotated property: definition
annotated target: Malignant mesothelioma that arises from the pleura. It is characterized by the presence of epithelioid and sarcomatoid components, with each component representing at least 10% of the tumor.
def-source: NCI

Axiom
annotated source: Pleural Biphasic Mesothelioma
annotated property: has exact synonym
annotated target: Pleural Biphasic Mesothelioma
term-group: PT
term-source: NCI

Anal Melanoma
type: Class
definition: A melanoma arising from the anus. Clinical presentation includes rectal bleeding, tenesmus, pain, and change in bowel habit. The prognosis is usually poor.
code: C4639
Semantic_Type: Neoplastic Process
Preferred_Name: Anal Melanoma
UMLS_CUI: C0349538
Neoplastic_Status: Malignant
Legacy_Concept_Name: Anal_Melanoma
has exact synonym: Anal Malignant Melanoma
has exact synonym: Anal Melanoma
has exact synonym: Malignant Melanoma of Anus
has exact synonym: Malignant Melanoma of the Anus
has exact synonym: Melanoma of Anus
has exact synonym: Melanoma of the Anus
in subset: oncotree slim

Axiom
annotated source: Anal Melanoma
annotated property: definition
annotated target: A melanoma arising from the anus. Clinical presentation includes rectal bleeding, tenesmus, pain, and change in bowel habit. The prognosis is usually poor.
def-source: NCI

Axiom
annotated source: Anal Melanoma
annotated property: has exact synonym
annotated target: Anal Malignant Melanoma
term-group: SY
term-source: NCI

Axiom
annotated source: Anal Melanoma
annotated property: has exact synonym
annotated target: Anal Melanoma
term-group: PT
term-source: NCI

Axiom
annotated source: Anal Melanoma
annotated property: has exact synonym
annotated target: Malignant Melanoma of Anus
term-group: SY
term-source: NCI

Axiom
annotated source: Anal Melanoma
annotated property: has exact synonym
annotated target: Malignant Melanoma of the Anus
term-group: SY
term-source: NCI

Axiom
annotated source: Anal Melanoma
annotated property: has exact synonym
annotated target: Melanoma of Anus
term-group: SY
term-source: NCI

Axiom
annotated source: Anal Melanoma
annotated property: has exact synonym
annotated target: Melanoma of the Anus
term-group: SY
term-source: NCI

Meningeal Solitary Fibrous Tumor/Hemangiopericytoma
type: Class
subclass of: Meningeal Neoplasm
definition: A solitary fibrous tumor/hemangiopericytoma that arises from the meninges.
Concept_In_Subset: NCIT C126659
code: C4660
Semantic_Type: Neoplastic Process
Preferred_Name: Meningeal Solitary Fibrous Tumor/Hemangiopericytoma
UMLS_CUI: C0349622
Neoplastic_Status: Undetermined
Legacy_Concept_Name: Meningeal_Hemangiopericytoma
has exact synonym: Hemangiopericytoma of Meninges
has exact synonym: Hemangiopericytoma of the Meninges
has exact synonym: Meningeal Hemangiopericytoma
has exact synonym: Meningeal Solitary Fibrous Tumor/Hemangiopericytoma
has exact synonym: Meninges Hemangiopericytoma
in subset: oncotree slim

Axiom
annotated source: Meningeal Solitary Fibrous Tumor/Hemangiopericytoma
annotated property: definition
annotated target: A solitary fibrous tumor/hemangiopericytoma that arises from the meninges.
def-source: NCI

Axiom
annotated source: Meningeal Solitary Fibrous Tumor/Hemangiopericytoma
annotated property: has exact synonym
annotated target: Hemangiopericytoma of Meninges
term-group: AQS
term-source: NCI

Axiom
annotated source: Meningeal Solitary Fibrous Tumor/Hemangiopericytoma
annotated property: has exact synonym
annotated target: Hemangiopericytoma of the Meninges
term-group: AQS
term-source: NCI

Axiom
annotated source: Meningeal Solitary Fibrous Tumor/Hemangiopericytoma
annotated property: has exact synonym
annotated target: Meningeal Hemangiopericytoma
term-group: AQS
term-source: NCI

Axiom
annotated source: Meningeal Solitary Fibrous Tumor/Hemangiopericytoma
annotated property: has exact synonym
annotated target: Meningeal Solitary Fibrous Tumor/Hemangiopericytoma
term-group: PT
term-source: NCI

Axiom
annotated source: Meningeal Solitary Fibrous Tumor/Hemangiopericytoma
annotated property: has exact synonym
annotated target: Meninges Hemangiopericytoma
term-group: AQS
term-source: NCI

Splenic Marginal Zone Lymphoma
type: Class
subclass of: Marginal Zone Lymphoma
definition: A B-cell non-Hodgkin lymphoma composed of small lymphocytes which surround and replace the splenic white pulp germinal centers. It involves the spleen and splenic hilar lymph nodes, bone marrow, and often the peripheral blood. When lymphoma cells are present in the peripheral blood, they are usually, but not always, characterized by the presence of short polar villi. (WHO)
Concept_In_Subset: NCIT C116977
Concept_In_Subset: NCIT C126659
code: C4663
Semantic_Type: Neoplastic Process
Display_Name: Splenic Marginal Zone Lymphoma
Preferred_Name: Splenic Marginal Zone Lymphoma
UMLS_CUI: C0349632
Contributing_Source: CTRP
ICD-O-3_Code: 9689/3
Neoplastic_Status: Malignant
Legacy_Concept_Name: Splenic_Marginal_Zone_Lymphoma
has exact synonym: Marginal Zone Lymphoma of Spleen
has exact synonym: Marginal Zone Lymphoma of the Spleen
has exact synonym: SLVL
has exact synonym: SMZL
has exact synonym: Splenic Lymphoma with Circulating Villous Lymphocytes
has exact synonym: Splenic Marginal Zone B-Cell Lymphoma
has exact synonym: Splenic Marginal Zone B-Cell Lymphoma with Villous Lymphocytes
has exact synonym: Splenic Marginal Zone Lymphoma
has exact synonym: Splenic Marginal Zone Lymphoma with Villous Lymphocytes
in subset: oncotree slim

Axiom
annotated source: Splenic Marginal Zone Lymphoma
annotated property: definition
annotated target: A B-cell non-Hodgkin lymphoma composed of small lymphocytes which surround and replace the splenic white pulp germinal centers. It involves the spleen and splenic hilar lymph nodes, bone marrow, and often the peripheral blood. When lymphoma cells are present in the peripheral blood, they are usually, but not always, characterized by the presence of short polar villi. (WHO)
def-source: NCI

Axiom
annotated source: Splenic Marginal Zone Lymphoma
annotated property: has exact synonym
annotated target: Marginal Zone Lymphoma of Spleen
term-group: SY
term-source: NCI

Axiom
annotated source: Splenic Marginal Zone Lymphoma
annotated property: has exact synonym
annotated target: Marginal Zone Lymphoma of the Spleen
term-group: SY
term-source: NCI

Axiom
annotated source: Splenic Marginal Zone Lymphoma
annotated property: has exact synonym
annotated target: SLVL
term-group: AB
term-source: NCI

Axiom
annotated source: Splenic Marginal Zone Lymphoma
annotated property: has exact synonym
annotated target: SMZL
term-group: AB
term-source: NCI

Axiom
annotated source: Splenic Marginal Zone Lymphoma
annotated property: has exact synonym
annotated target: Splenic Lymphoma with Circulating Villous Lymphocytes
term-group: SY
term-source: NCI

Axiom
annotated source: Splenic Marginal Zone Lymphoma
annotated property: has exact synonym
annotated target: Splenic Marginal Zone B-Cell Lymphoma
term-group: SY
term-source: NCI

Axiom
annotated source: Splenic Marginal Zone Lymphoma
annotated property: has exact synonym
annotated target: Splenic Marginal Zone B-Cell Lymphoma with Villous Lymphocytes
term-group: SY
term-source: NCI

Axiom
annotated source: Splenic Marginal Zone Lymphoma
annotated property: has exact synonym
annotated target: Splenic Marginal Zone Lymphoma
term-group: PT
term-source: NCI

Axiom
annotated source: Splenic Marginal Zone Lymphoma
annotated property: has exact synonym
annotated target: Splenic Marginal Zone Lymphoma
term-group: SY
term-source: NCI
source-code: TCGA
subsource-name: caDSR

Axiom
annotated source: Splenic Marginal Zone Lymphoma
annotated property: has exact synonym
annotated target: Splenic Marginal Zone Lymphoma with Villous Lymphocytes
term-group: SY
term-source: NCI

T-Cell Large Granular Lymphocyte Leukemia
type: Class
definition: A T-cell peripheral neoplasm characterized by a persistent (>6 months) increase in the number of peripheral blood large granular lymphocytes, without a clearly identified cause. (WHO, 2001)
Concept_In_Subset: NCIT C102905
Concept_In_Subset: NCIT C103125
Concept_In_Subset: NCIT C116977
Concept_In_Subset: NCIT C126659
Concept_In_Subset: NCIT C61410
Concept_In_Subset: NCIT C77526
Concept_In_Subset: NCIT C88025
code: C4664
Semantic_Type: Neoplastic Process
Display_Name: T-Cell Large Granular Lymphocyte Leukemia
Preferred_Name: T-Cell Large Granular Lymphocyte Leukemia
UMLS_CUI: C1955861
Contributing_Source: CDISC
Contributing_Source: CTEP
Contributing_Source: CTRP
ALT_DEFINITION: A progressive, proliferative disease of blood cells which are large and granular, originating from lymphoid cells.
ALT_DEFINITION: A type of leukemia in which large T lymphocytes (a type of white blood cell) that contain granules (small particles) are found in the blood. It is a chronic disease that may last for a long time and get worse.
ICD-O-3_Code: 9768/1
ICD-O-3_Code: 9831/1
ICD-O-3_Code: 9831/3
Neoplastic_Status: Malignant
Legacy_Concept_Name: T-Cell_Large_Granular_Lymphocyte_Leukemia
has exact synonym: LEUKEMIA, LARGE GRANULAR LYMPHOCYTIC, MALIGNANT
has exact synonym: LGLL
has exact synonym: Large Cell Granular Lymphogenous Leukemia
has exact synonym: Large Cell Granular Lymphoid Leukemia
has exact synonym: Large Granular Lymphocytic Leukemia
has exact synonym: Large Granular Lymphocytosis
has exact synonym: T Gamma Lymphoproliferative Disorder
has exact synonym: T-Cell Large Granular Lymphocyte Leukemia
has exact synonym: T-Cell Large Granular Lymphocytic Leukemia
has exact synonym: T-Gamma Lymphoproliferative Disorder
has exact synonym: T-LGL leukemia
has exact synonym: T-cell large gran. lymph. leuk.
has exact synonym: T-cell large granular lymphocyte leukemia
has exact synonym: T-cell large granular lymphocytic leukemia
has exact synonym: Tgamma Large Granular Lymphocyte Leukemia
in subset: oncotree slim

Axiom
annotated source: T-Cell Large Granular Lymphocyte Leukemia
annotated property: definition
annotated target: A T-cell peripheral neoplasm characterized by a persistent (>6 months) increase in the number of peripheral blood large granular lymphocytes, without a clearly identified cause. (WHO, 2001)
def-source: NCI

Axiom
annotated source: T-Cell Large Granular Lymphocyte Leukemia
annotated property: ALT_DEFINITION
annotated target: A progressive, proliferative disease of blood cells which are large and granular, originating from lymphoid cells.
def-source: CDISC

Axiom
annotated source: T-Cell Large Granular Lymphocyte Leukemia
annotated property: ALT_DEFINITION
annotated target: A type of leukemia in which large T lymphocytes (a type of white blood cell) that contain granules (small particles) are found in the blood. It is a chronic disease that may last for a long time and get worse.
def-source: NCI-GLOSS

Axiom
annotated source: T-Cell Large Granular Lymphocyte Leukemia
annotated property: has exact synonym
annotated target: LEUKEMIA, LARGE GRANULAR LYMPHOCYTIC, MALIGNANT
term-group: PT
term-source: CDISC

Axiom
annotated source: T-Cell Large Granular Lymphocyte Leukemia
annotated property: has exact synonym
annotated target: LGLL
term-group: AB
term-source: NCI

Axiom
annotated source: T-Cell Large Granular Lymphocyte Leukemia
annotated property: has exact synonym
annotated target: LGLL
term-group: SY
term-source: CDISC

Axiom
annotated source: T-Cell Large Granular Lymphocyte Leukemia
annotated property: has exact synonym
annotated target: Large Cell Granular Lymphogenous Leukemia
term-group: SY
term-source: CDISC

Axiom
annotated source: T-Cell Large Granular Lymphocyte Leukemia
annotated property: has exact synonym
annotated target: Large Cell Granular Lymphogenous Leukemia
term-group: SY
term-source: NCI

Axiom
annotated source: T-Cell Large Granular Lymphocyte Leukemia
annotated property: has exact synonym
annotated target: Large Cell Granular Lymphoid Leukemia
term-group: SY
term-source: CDISC

Axiom
annotated source: T-Cell Large Granular Lymphocyte Leukemia
annotated property: has exact synonym
annotated target: Large Cell Granular Lymphoid Leukemia
term-group: SY
term-source: NCI

Axiom
annotated source: T-Cell Large Granular Lymphocyte Leukemia
annotated property: has exact synonym
annotated target: Large Granular Lymphocytic Leukemia
term-group: SY
term-source: CDISC

Axiom
annotated source: T-Cell Large Granular Lymphocyte Leukemia
annotated property: has exact synonym
annotated target: Large Granular Lymphocytic Leukemia
term-group: SY
term-source: NCI

Axiom
annotated source: T-Cell Large Granular Lymphocyte Leukemia
annotated property: has exact synonym
annotated target: Large Granular Lymphocytosis
term-group: SY
term-source: CDISC

Axiom
annotated source: T-Cell Large Granular Lymphocyte Leukemia
annotated property: has exact synonym
annotated target: Large Granular Lymphocytosis
term-group: SY
term-source: NCI

Axiom
annotated source: T-Cell Large Granular Lymphocyte Leukemia
annotated property: has exact synonym
annotated target: T Gamma Lymphoproliferative Disorder
term-group: SY
term-source: CDISC

Axiom
annotated source: T-Cell Large Granular Lymphocyte Leukemia
annotated property: has exact synonym
annotated target: T Gamma Lymphoproliferative Disorder
term-group: SY
term-source: NCI

Axiom
annotated source: T-Cell Large Granular Lymphocyte Leukemia
annotated property: has exact synonym
annotated target: T-Cell Large Granular Lymphocyte Leukemia
term-group: PT
term-source: NCI

Axiom
annotated source: T-Cell Large Granular Lymphocyte Leukemia
annotated property: has exact synonym
annotated target: T-Cell Large Granular Lymphocyte Leukemia
term-group: SY
term-source: NCI
source-code: TCGA
subsource-name: caDSR

Axiom
annotated source: T-Cell Large Granular Lymphocyte Leukemia
annotated property: has exact synonym
annotated target: T-Cell Large Granular Lymphocytic Leukemia
term-group: SY
term-source: CDISC

Axiom
annotated source: T-Cell Large Granular Lymphocyte Leukemia
annotated property: has exact synonym
annotated target: T-Cell Large Granular Lymphocytic Leukemia
term-group: SY
term-source: NCI

Axiom
annotated source: T-Cell Large Granular Lymphocyte Leukemia
annotated property: has exact synonym
annotated target: T-Gamma Lymphoproliferative Disorder
term-group: SY
term-source: CDISC

Axiom
annotated source: T-Cell Large Granular Lymphocyte Leukemia
annotated property: has exact synonym
annotated target: T-Gamma Lymphoproliferative Disorder
term-group: SY
term-source: NCI

Axiom
annotated source: T-Cell Large Granular Lymphocyte Leukemia
annotated property: has exact synonym
annotated target: T-LGL leukemia
term-group: PT
term-source: NCI-GLOSS
source-code: CDR0000633893

Axiom
annotated source: T-Cell Large Granular Lymphocyte Leukemia
annotated property: has exact synonym
annotated target: T-cell large gran. lymph. leuk.
term-group: SY
term-source: CTEP
source-code: 10065862
subsource-name: SDC

Axiom
annotated source: T-Cell Large Granular Lymphocyte Leukemia
annotated property: has exact synonym
annotated target: T-cell large granular lymphocyte leukemia
term-group: PT
term-source: NCI-GLOSS
source-code: CDR0000633892

Axiom
annotated source: T-Cell Large Granular Lymphocyte Leukemia
annotated property: has exact synonym
annotated target: T-cell large granular lymphocytic leukemia
term-group: PT
term-source: CTEP
source-code: 10065862
subsource-name: SDC

Axiom
annotated source: T-Cell Large Granular Lymphocyte Leukemia
annotated property: has exact synonym
annotated target: Tgamma Large Granular Lymphocyte Leukemia
term-group: SY
term-source: CDISC

Breast Sarcoma
type: Class
definition: A malignant mesenchymal neoplasm that arises from the breast. Representative examples include angiosarcoma, liposarcoma, leiomyosarcoma, rhabdomyosarcoma, and extraskeletal osteosarcoma.
code: C4670
Semantic_Type: Neoplastic Process
Preferred_Name: Breast Sarcoma
UMLS_CUI: C0349667
Neoplastic_Status: Malignant
Legacy_Concept_Name: Breast_Sarcoma
has exact synonym: Breast Sarcoma
has exact synonym: Sarcoma of Breast
has exact synonym: Sarcoma of the Breast
in subset: oncotree slim

Axiom
annotated source: Breast Sarcoma
annotated property: definition
annotated target: A malignant mesenchymal neoplasm that arises from the breast. Representative examples include angiosarcoma, liposarcoma, leiomyosarcoma, rhabdomyosarcoma, and extraskeletal osteosarcoma.
def-source: NCI

Axiom
annotated source: Breast Sarcoma
annotated property: has exact synonym
annotated target: Breast Sarcoma
term-group: PT
term-source: NCI

Axiom
annotated source: Breast Sarcoma
annotated property: has exact synonym
annotated target: Sarcoma of Breast
term-group: SY
term-source: NCI

Axiom
annotated source: Breast Sarcoma
annotated property: has exact synonym
annotated target: Sarcoma of the Breast
term-group: SY
term-source: NCI

Dermatofibrosarcoma Protuberans
type: Class
definition: A low grade fibroblastic neoplasm presenting as a nodular cutaneous mass, most often on the trunk and the proximal extremities. The tumor diffusely infiltrates the dermis and the subcutaneous tissues. It is considered a locally aggressive neoplasm, which often recurs but rarely metastasizes.
Concept_In_Subset: NCIT C102905
Concept_In_Subset: NCIT C103117
Concept_In_Subset: NCIT C116977
Concept_In_Subset: NCIT C126659
code: C4683
Semantic_Type: Neoplastic Process
Display_Name: Dermatofibrosarcoma Protuberans
Preferred_Name: Dermatofibrosarcoma Protuberans
UMLS_CUI: C0392784
Contributing_Source: CTEP
Contributing_Source: CTRP
ALT_DEFINITION: A type of tumor that begins as a hard nodule and grows slowly. These tumors are usually found in the dermis (the inner layer of the two main layers of tissue that make up the skin) of the limbs or trunk of the body. They can grow into surrounding tissue but do not spread to other parts of the body. These tumors are related to giant cell fibroblastomas.
ICD-O-3_Code: 8832/3
Neoplastic_Status: Undetermined
Legacy_Concept_Name: Dermatofibrosarcoma_Protuberans
has exact synonym: DFSP
has exact synonym: Dermatofibrosarcoma
has exact synonym: Dermatofibrosarcoma Protuberans
has exact synonym: dermatofibrosarcoma protuberans
in subset: oncotree slim

Axiom
annotated source: Dermatofibrosarcoma Protuberans
annotated property: definition
annotated target: A low grade fibroblastic neoplasm presenting as a nodular cutaneous mass, most often on the trunk and the proximal extremities. The tumor diffusely infiltrates the dermis and the subcutaneous tissues. It is considered a locally aggressive neoplasm, which often recurs but rarely metastasizes.
def-source: NCI

Axiom
annotated source: Dermatofibrosarcoma Protuberans
annotated property: ALT_DEFINITION
annotated target: A type of tumor that begins as a hard nodule and grows slowly. These tumors are usually found in the dermis (the inner layer of the two main layers of tissue that make up the skin) of the limbs or trunk of the body. They can grow into surrounding tissue but do not spread to other parts of the body. These tumors are related to giant cell fibroblastomas.
def-source: NCI-GLOSS

Axiom
annotated source: Dermatofibrosarcoma Protuberans
annotated property: has exact synonym
annotated target: DFSP
term-group: AB
term-source: NCI

Axiom
annotated source: Dermatofibrosarcoma Protuberans
annotated property: has exact synonym
annotated target: Dermatofibrosarcoma
term-group: PT
term-source: CTEP
source-code: 10057043
subsource-name: SDC

Axiom
annotated source: Dermatofibrosarcoma Protuberans
annotated property: has exact synonym
annotated target: Dermatofibrosarcoma
term-group: SY
term-source: NCI

Axiom
annotated source: Dermatofibrosarcoma Protuberans
annotated property: has exact synonym
annotated target: Dermatofibrosarcoma Protuberans
term-group: PT
term-source: NCI

Axiom
annotated source: Dermatofibrosarcoma Protuberans
annotated property: has exact synonym
annotated target: dermatofibrosarcoma protuberans
term-group: PT
term-source: NCI-GLOSS
source-code: CDR0000044276

Gestational Trophoblastic Tumor
type: Class
definition: A diverse group of pregnancy-related tumors characterized by excessive proliferation of trophoblasts. Representative examples include hydatidiform mole, gestational choriocarcinoma, and placental site trophoblastic tumor.
Concept_In_Subset: NCIT C102905
Concept_In_Subset: NCIT C103101
Concept_In_Subset: NCIT C116977
Concept_In_Subset: NCIT C126659
code: C4699
Semantic_Type: Neoplastic Process
Display_Name: Gestational Trophoblastic Tumor
Preferred_Name: Gestational Trophoblastic Tumor
UMLS_CUI: C1135868
Contributing_Source: CTEP
Contributing_Source: CTRP
ALT_DEFINITION: Any of a group of tumors that develops from trophoblastic cells (cells that help an embryo attach to the uterus and help form the placenta) after fertilization of an egg by a sperm. The two main types of gestational trophoblastic tumors are hydatidiform mole and choriocarcinoma.
Neoplastic_Status: Undetermined
Legacy_Concept_Name: Gestational_Trophoblastic_Tumor
has exact synonym: GTT
has exact synonym: Gestational Trophoblastic Disease
has exact synonym: Gestational Trophoblastic Neoplasm
has exact synonym: Gestational Trophoblastic Tumor
has exact synonym: Gestational trophoblastic disease
has exact synonym: gestational trophoblastic disease
has exact synonym: gestational trophoblastic neoplasia
has exact synonym: gestational trophoblastic tumor
in subset: oncotree slim

Axiom
annotated source: Gestational Trophoblastic Tumor
annotated property: definition
annotated target: A diverse group of pregnancy-related tumors characterized by excessive proliferation of trophoblasts. Representative examples include hydatidiform mole, gestational choriocarcinoma, and placental site trophoblastic tumor.
def-source: NCI

Axiom
annotated source: Gestational Trophoblastic Tumor
annotated property: ALT_DEFINITION
annotated target: Any of a group of tumors that develops from trophoblastic cells (cells that help an embryo attach to the uterus and help form the placenta) after fertilization of an egg by a sperm. The two main types of gestational trophoblastic tumors are hydatidiform mole and choriocarcinoma.
def-source: NCI-GLOSS

Axiom
annotated source: Gestational Trophoblastic Tumor
annotated property: has exact synonym
annotated target: GTT
term-group: AB
term-source: NCI

Axiom
annotated source: Gestational Trophoblastic Tumor
annotated property: has exact synonym
annotated target: Gestational Trophoblastic Disease
term-group: SY
term-source: NCI

Axiom
annotated source: Gestational Trophoblastic Tumor
annotated property: has exact synonym
annotated target: Gestational Trophoblastic Neoplasm
term-group: SY
term-source: NCI

Axiom
annotated source: Gestational Trophoblastic Tumor
annotated property: has exact synonym
annotated target: Gestational Trophoblastic Tumor
term-group: DN
term-source: CTRP

Axiom
annotated source: Gestational Trophoblastic Tumor
annotated property: has exact synonym
annotated target: Gestational Trophoblastic Tumor
term-group: PT
term-source: CTRP

Axiom
annotated source: Gestational Trophoblastic Tumor
annotated property: has exact synonym
annotated target: Gestational Trophoblastic Tumor
term-group: PT
term-source: NCI

Axiom
annotated source: Gestational Trophoblastic Tumor
annotated property: has exact synonym
annotated target: Gestational trophoblastic disease
term-group: PT
term-source: CTEP
source-code: 10018212
subsource-name: SDC

Axiom
annotated source: Gestational Trophoblastic Tumor
annotated property: has exact synonym
annotated target: gestational trophoblastic disease
term-group: PT
term-source: NCI-GLOSS
source-code: CDR0000046199

Axiom
annotated source: Gestational Trophoblastic Tumor
annotated property: has exact synonym
annotated target: gestational trophoblastic neoplasia
term-group: PT
term-source: NCI-GLOSS
source-code: CDR0000046750

Axiom
annotated source: Gestational Trophoblastic Tumor
annotated property: has exact synonym
annotated target: gestational trophoblastic tumor
term-group: PT
term-source: NCI-GLOSS
source-code: CDR0000045115

Clear Cell Ependymoma
type: Class
subclass of: Ependymoma
definition: An ependymoma, often supratentorial in location, characterized by the presence of ependymal cells with a perinuclear halo.
Concept_In_Subset: NCIT C126659
code: C4714
Semantic_Type: Neoplastic Process
Preferred_Name: Clear Cell Ependymoma
UMLS_CUI: C1384404
Neoplastic_Status: Undetermined
Legacy_Concept_Name: Clear_Cell_Ependymoma
has exact synonym: Clear Cell Ependymoma
in subset: oncotree slim

Axiom
annotated source: Clear Cell Ependymoma
annotated property: definition
annotated target: An ependymoma, often supratentorial in location, characterized by the presence of ependymal cells with a perinuclear halo.
def-source: NCI

Axiom
annotated source: Clear Cell Ependymoma
annotated property: has exact synonym
annotated target: Clear Cell Ependymoma
term-group: PT
term-source: NCI

Choroid Plexus Carcinoma
type: Class
definition: A malignant neoplasm arising from the choroid plexus. It shows anaplastic features and usually invades neighboring brain structures. Cerebrospinal fluid metastases are frequent. (Adapted from WHO)
Concept_In_Subset: NCIT C102905
Concept_In_Subset: NCIT C103044
Concept_In_Subset: NCIT C126659
Concept_In_Subset: NCIT C61410
Concept_In_Subset: NCIT C77526
Concept_In_Subset: NCIT C88025
code: C4715
Semantic_Type: Neoplastic Process
Preferred_Name: Choroid Plexus Carcinoma
UMLS_CUI: C0431109
Contributing_Source: CDISC
Contributing_Source: CTEP
ALT_DEFINITION: A malignant neoplasm arising from the choroid plexus of the brain.
ICD-O-3_Code: 9390/3
Neoplastic_Status: Malignant
Legacy_Concept_Name: Choroid_Plexus_Carcinoma
has exact synonym: Anaplastic Choroid Plexus Papilloma
has exact synonym: CARCINOMA, CHOROID PLEXUS, MALIGNANT
has exact synonym: Cancer of Choroid Plexus
has exact synonym: Cancer of the Choroid Plexus
has exact synonym: Carcinoma of Choroid Plexus
has exact synonym: Carcinoma of the Choroid Plexus
has exact synonym: Choroid Plexus Cancer
has exact synonym: Choroid Plexus Carcinoma
has exact synonym: Choroid plexus carcinoma
in subset: oncotree slim

Axiom
annotated source: Choroid Plexus Carcinoma
annotated property: definition
annotated target: A malignant neoplasm arising from the choroid plexus. It shows anaplastic features and usually invades neighboring brain structures. Cerebrospinal fluid metastases are frequent. (Adapted from WHO)
def-source: NCI

Axiom
annotated source: Choroid Plexus Carcinoma
annotated property: ALT_DEFINITION
annotated target: A malignant neoplasm arising from the choroid plexus of the brain.
def-source: CDISC

Axiom
annotated source: Choroid Plexus Carcinoma
annotated property: has exact synonym
annotated target: Anaplastic Choroid Plexus Papilloma
term-group: AQS
term-source: NCI

Axiom
annotated source: Choroid Plexus Carcinoma
annotated property: has exact synonym
annotated target: Anaplastic Choroid Plexus Papilloma
term-group: SY
term-source: CDISC

Axiom
annotated source: Choroid Plexus Carcinoma
annotated property: has exact synonym
annotated target: CARCINOMA, CHOROID PLEXUS, MALIGNANT
term-group: PT
term-source: CDISC

Axiom
annotated source: Choroid Plexus Carcinoma
annotated property: has exact synonym
annotated target: Cancer of Choroid Plexus
term-group: SY
term-source: CDISC

Axiom
annotated source: Choroid Plexus Carcinoma
annotated property: has exact synonym
annotated target: Cancer of Choroid Plexus
term-group: SY
term-source: NCI

Axiom
annotated source: Choroid Plexus Carcinoma
annotated property: has exact synonym
annotated target: Cancer of the Choroid Plexus
term-group: SY
term-source: CDISC

Axiom
annotated source: Choroid Plexus Carcinoma
annotated property: has exact synonym
annotated target: Cancer of the Choroid Plexus
term-group: SY
term-source: NCI

Axiom
annotated source: Choroid Plexus Carcinoma
annotated property: has exact synonym
annotated target: Carcinoma of Choroid Plexus
term-group: SY
term-source: CDISC

Axiom
annotated source: Choroid Plexus Carcinoma
annotated property: has exact synonym
annotated target: Carcinoma of Choroid Plexus
term-group: SY
term-source: NCI

Axiom
annotated source: Choroid Plexus Carcinoma
annotated property: has exact synonym
annotated target: Carcinoma of the Choroid Plexus
term-group: SY
term-source: CDISC

Axiom
annotated source: Choroid Plexus Carcinoma
annotated property: has exact synonym
annotated target: Carcinoma of the Choroid Plexus
term-group: SY
term-source: NCI

Axiom
annotated source: Choroid Plexus Carcinoma
annotated property: has exact synonym
annotated target: Choroid Plexus Cancer
term-group: DN
term-source: CTRP

Axiom
annotated source: Choroid Plexus Carcinoma
annotated property: has exact synonym
annotated target: Choroid Plexus Cancer
term-group: SY
term-source: CDISC

Axiom
annotated source: Choroid Plexus Carcinoma
annotated property: has exact synonym
annotated target: Choroid Plexus Cancer
term-group: SY
term-source: NCI

Axiom
annotated source: Choroid Plexus Carcinoma
annotated property: has exact synonym
annotated target: Choroid Plexus Carcinoma
term-group: PT
term-source: CTRP

Axiom
annotated source: Choroid Plexus Carcinoma
annotated property: has exact synonym
annotated target: Choroid Plexus Carcinoma
term-group: PT
term-source: NCI

Axiom
annotated source: Choroid Plexus Carcinoma
annotated property: has exact synonym
annotated target: Choroid Plexus Carcinoma
term-group: SY
term-source: NCI
source-code: TCGA
subsource-name: caDSR

Axiom
annotated source: Choroid Plexus Carcinoma
annotated property: has exact synonym
annotated target: Choroid plexus carcinoma
term-group: PT
term-source: CTEP
source-code: 90600120
subsource-name: SDC

Anaplastic Ganglioglioma
type: Class
definition: A WHO grade III neuroepithelial neoplasm composed of neoplastic, mature ganglion cells and anaplastic glial cells. The anaplastic changes in the glial component and high MIB-1 and TP53 labeling indices may indicate aggressive behavior. However, the correlation of histological anaplasia with clinical outcome is inconsistent. (Adapted from WHO)
code: C4717
Semantic_Type: Neoplastic Process
Preferred_Name: Anaplastic Ganglioglioma
UMLS_CUI: C0431112
ICD-O-3_Code: 9505/3
Neoplastic_Status: Malignant
Legacy_Concept_Name: Anaplastic_Ganglioglioma
has exact synonym: Anaplastic Ganglioglioma
in subset: oncotree slim

Axiom
annotated source: Anaplastic Ganglioglioma
annotated property: definition
annotated target: A WHO grade III neuroepithelial neoplasm composed of neoplastic, mature ganglion cells and anaplastic glial cells. The anaplastic changes in the glial component and high MIB-1 and TP53 labeling indices may indicate aggressive behavior. However, the correlation of histological anaplasia with clinical outcome is inconsistent. (Adapted from WHO)
def-source: NCI

Axiom
annotated source: Anaplastic Ganglioglioma
annotated property: has exact synonym
annotated target: Anaplastic Ganglioglioma
term-group: PT
term-source: NCI

Clear Cell Meningioma
type: Class
definition: A WHO grade II morphologic variant of meningioma characterized by the presence of clear glycogen-rich polygonal cells.
Concept_In_Subset: NCIT C126659
code: C4722
Semantic_Type: Neoplastic Process
Preferred_Name: Clear Cell Meningioma
UMLS_CUI: C0431121
ICD-O-3_Code: 9538/1
Neoplastic_Status: Undetermined
Legacy_Concept_Name: Clear_Cell_Meningioma
has exact synonym: Clear Cell Meningioma
in subset: oncotree slim

Axiom
annotated source: Clear Cell Meningioma
annotated property: definition
annotated target: A WHO grade II morphologic variant of meningioma characterized by the presence of clear glycogen-rich polygonal cells.
def-source: NCI

Axiom
annotated source: Clear Cell Meningioma
annotated property: has exact synonym
annotated target: Clear Cell Meningioma
term-group: PT
term-source: NCI

Axiom
annotated source: Clear Cell Meningioma
annotated property: has exact synonym
annotated target: Clear Cell Meningioma
term-group: SY
term-source: NCI
source-code: TCGA
subsource-name: caDSR

Atypical Meningioma
type: Class
definition: A WHO grade II meningioma characterized by the presence of brain invasion and an increased mitotic activity, or at least three of the following morphologic features: small cells, high cellularity, prominent nucleoli, lack of architectural pattern, and necrosis.
Concept_In_Subset: NCIT C126659
code: C4723
Semantic_Type: Neoplastic Process
Preferred_Name: Atypical Meningioma
UMLS_CUI: C0431122
ICD-O-3_Code: 9539/1
Neoplastic_Status: Undetermined
Legacy_Concept_Name: Atypical_Meningioma
has exact synonym: Atypical Meningioma
in subset: oncotree slim

Axiom
annotated source: Atypical Meningioma
annotated property: definition
annotated target: A WHO grade II meningioma characterized by the presence of brain invasion and an increased mitotic activity, or at least three of the following morphologic features: small cells, high cellularity, prominent nucleoli, lack of architectural pattern, and necrosis.
def-source: NCI

Axiom
annotated source: Atypical Meningioma
annotated property: has exact synonym
annotated target: Atypical Meningioma
term-group: PT
term-source: NCI

Axiom
annotated source: Atypical Meningioma
annotated property: has exact synonym
annotated target: Atypical Meningioma
term-group: SY
term-source: NCI
source-code: TCGA
subsource-name: caDSR

Cellular Schwannoma
type: Class
subclass of: Schwannoma
definition: A morphologic variant of schwannoma characterized by hypercellularity, Antoni A pattern, and the absence of well-formed Verocay bodies.
code: C4724
Semantic_Type: Neoplastic Process
Preferred_Name: Cellular Schwannoma
UMLS_CUI: C0431124
Neoplastic_Status: Benign
Legacy_Concept_Name: Cellular_Schwannoma
has exact synonym: Cellular Neurilemmoma
has exact synonym: Cellular Neurinoma
has exact synonym: Cellular Schwannoma
in subset: oncotree slim

Axiom
annotated source: Cellular Schwannoma
annotated property: definition
annotated target: A morphologic variant of schwannoma characterized by hypercellularity, Antoni A pattern, and the absence of well-formed Verocay bodies.
def-source: NCI

Axiom
annotated source: Cellular Schwannoma
annotated property: has exact synonym
annotated target: Cellular Neurilemmoma
term-group: SY
term-source: NCI

Axiom
annotated source: Cellular Schwannoma
annotated property: has exact synonym
annotated target: Cellular Neurinoma
term-group: SY
term-source: NCI

Axiom
annotated source: Cellular Schwannoma
annotated property: has exact synonym
annotated target: Cellular Schwannoma
term-group: PT
term-source: NCI

Axiom
annotated source: Cellular Schwannoma
annotated property: has exact synonym
annotated target: Cellular Schwannoma
term-group: SY
term-source: NCI
source-code: TCGA
subsource-name: caDSR

Papillary Craniopharyngioma
type: Class
definition: A craniopharyngioma composed of sheets of squamous epithelium which separate to form pseudopapillae. This variant typically lacks nuclear palisading, wet keratin, calcification, and cholesterol deposits. Clinically, endocrine deficiencies are more often associated with papillary craniopharyngioma than with the adamantinomatous type. (Adapted from WHO)
code: C4725
Semantic_Type: Neoplastic Process
Preferred_Name: Papillary Craniopharyngioma
UMLS_CUI: C0431128
ICD-O-3_Code: 9352/1
Neoplastic_Status: Benign
Legacy_Concept_Name: Papillary_Craniopharyngioma
has exact synonym: Papillary Craniopharyngioma
has exact synonym: Papillary Neoplasm of Rathke's Pouch
has exact synonym: Papillary Rathke Pouch Neoplasm
has exact synonym: Papillary Rathke's Pouch Neoplasm
has exact synonym: Papillary Rathke's Pouch Tumor
has exact synonym: Papillary Tumor of Rathke's Pouch
in subset: oncotree slim

Axiom
annotated source: Papillary Craniopharyngioma
annotated property: definition
annotated target: A craniopharyngioma composed of sheets of squamous epithelium which separate to form pseudopapillae. This variant typically lacks nuclear palisading, wet keratin, calcification, and cholesterol deposits. Clinically, endocrine deficiencies are more often associated with papillary craniopharyngioma than with the adamantinomatous type. (Adapted from WHO)
def-source: NCI

Axiom
annotated source: Papillary Craniopharyngioma
annotated property: has exact synonym
annotated target: Papillary Craniopharyngioma
term-group: PT
term-source: NCI

Axiom
annotated source: Papillary Craniopharyngioma
annotated property: has exact synonym
annotated target: Papillary Craniopharyngioma
term-group: SY
term-source: NCI
source-code: TCGA
subsource-name: caDSR

Axiom
annotated source: Papillary Craniopharyngioma
annotated property: has exact synonym
annotated target: Papillary Neoplasm of Rathke's Pouch
term-group: SY
term-source: NCI

Axiom
annotated source: Papillary Craniopharyngioma
annotated property: has exact synonym
annotated target: Papillary Rathke Pouch Neoplasm
term-group: SY
term-source: NCI

Axiom
annotated source: Papillary Craniopharyngioma
annotated property: has exact synonym
annotated target: Papillary Rathke's Pouch Neoplasm
term-group: SY
term-source: NCI

Axiom
annotated source: Papillary Craniopharyngioma
annotated property: has exact synonym
annotated target: Papillary Rathke's Pouch Tumor
term-group: SY
term-source: NCI

Axiom
annotated source: Papillary Craniopharyngioma
annotated property: has exact synonym
annotated target: Papillary Tumor of Rathke's Pouch
term-group: SY
term-source: NCI

Adamantinomatous Craniopharyngioma
type: Class
definition: A craniopharyngioma consisting of broad strands, cords and bridges of a multistratified squamous epithelium with peripheral palisading of nuclei. Diagnostic features include nodules of compact 'wet' keratin and dystrophic calcification. (Adapted from WHO)
code: C4726
Semantic_Type: Neoplastic Process
Preferred_Name: Adamantinomatous Craniopharyngioma
UMLS_CUI: C0431129
ICD-O-3_Code: 9351/1
Neoplastic_Status: Benign
Legacy_Concept_Name: Adamantinous_Craniopharyngioma
has exact synonym: Adamantinomatous Craniopharyngioma
has exact synonym: Adamantinous Craniopharyngioma
has exact synonym: Adamantinous Neoplasm of Rathke's Pouch
has exact synonym: Adamantinous Rathke's Pouch Neoplasm
has exact synonym: Adamantinous Rathke's Pouch Tumor
has exact synonym: Adamantinous Tumor of Rathke's Pouch
in subset: oncotree slim

Axiom
annotated source: Adamantinomatous Craniopharyngioma
annotated property: definition
annotated target: A craniopharyngioma consisting of broad strands, cords and bridges of a multistratified squamous epithelium with peripheral palisading of nuclei. Diagnostic features include nodules of compact 'wet' keratin and dystrophic calcification. (Adapted from WHO)
def-source: NCI

Axiom
annotated source: Adamantinomatous Craniopharyngioma
annotated property: has exact synonym
annotated target: Adamantinomatous Craniopharyngioma
term-group: PT
term-source: NCI

Axiom
annotated source: Adamantinomatous Craniopharyngioma
annotated property: has exact synonym
annotated target: Adamantinomatous Craniopharyngioma
term-group: SY
term-source: NCI
source-code: TCGA
subsource-name: caDSR

Axiom
annotated source: Adamantinomatous Craniopharyngioma
annotated property: has exact synonym
annotated target: Adamantinous Craniopharyngioma
term-group: SY
term-source: NCI

Axiom
annotated source: Adamantinomatous Craniopharyngioma
annotated property: has exact synonym
annotated target: Adamantinous Neoplasm of Rathke's Pouch
term-group: SY
term-source: NCI

Axiom
annotated source: Adamantinomatous Craniopharyngioma
annotated property: has exact synonym
annotated target: Adamantinous Rathke's Pouch Neoplasm
term-group: SY
term-source: NCI

Axiom
annotated source: Adamantinomatous Craniopharyngioma
annotated property: has exact synonym
annotated target: Adamantinous Rathke's Pouch Tumor
term-group: SY
term-source: NCI

Axiom
annotated source: Adamantinomatous Craniopharyngioma
annotated property: has exact synonym
annotated target: Adamantinous Tumor of Rathke's Pouch
term-group: SY
term-source: NCI

Desmoplastic Infantile Ganglioglioma
type: Class
definition: A WHO grade I large cystic tumor that occurs almost exclusively in infants, with a prominent desmoplastic stroma having a neuroepithelial population of neoplastic astrocytes together with a variable neuronal component. It involves the superficial cerebral cortex and leptomeninges, and often attaches to the dura. Although clinically it presents as a large tumor, it generally has a good prognosis following surgical resection. (Adapted from WHO)
Has_NICHD_Parent: NCIT C27362
Concept_In_Subset: NCIT C126659
Concept_In_Subset: NCIT C132009
Concept_In_Subset: NCIT C90259
code: C4738
Semantic_Type: Neoplastic Process
Preferred_Name: Desmoplastic Infantile Ganglioglioma
UMLS_CUI: C1321878
Contributing_Source: NICHD
ALT_DEFINITION: A WHO grade I large cystic tumor that occurs almost exclusively in infants. It involves the superficial cerebral cortex and leptomeninges, and often attaches to the dura.
Neoplastic_Status: Undetermined
Legacy_Concept_Name: Desmoplastic_Infantile_Ganglioglioma
NICHD_Hierarchy_Term: Desmoplastic Infantile Ganglioglioma
has exact synonym: DIG
has exact synonym: Desmoplastic Infantile Ganglioglioma
in subset: oncotree slim

Axiom
annotated source: Desmoplastic Infantile Ganglioglioma
annotated property: definition
annotated target: A WHO grade I large cystic tumor that occurs almost exclusively in infants, with a prominent desmoplastic stroma having a neuroepithelial population of neoplastic astrocytes together with a variable neuronal component. It involves the superficial cerebral cortex and leptomeninges, and often attaches to the dura. Although clinically it presents as a large tumor, it generally has a good prognosis following surgical resection. (Adapted from WHO)
def-source: NCI

Axiom
annotated source: Desmoplastic Infantile Ganglioglioma
annotated property: ALT_DEFINITION
annotated target: A WHO grade I large cystic tumor that occurs almost exclusively in infants. It involves the superficial cerebral cortex and leptomeninges, and often attaches to the dura.
def-source: NICHD

Axiom
annotated source: Desmoplastic Infantile Ganglioglioma
annotated property: has exact synonym
annotated target: DIG
term-group: AB
term-source: NCI

Axiom
annotated source: Desmoplastic Infantile Ganglioglioma
annotated property: has exact synonym
annotated target: Desmoplastic Infantile Ganglioglioma
term-group: PT
term-source: NCI

Axiom
annotated source: Desmoplastic Infantile Ganglioglioma
annotated property: has exact synonym
annotated target: Desmoplastic Infantile Ganglioglioma
term-group: PT
term-source: NICHD

Axiom
annotated source: Desmoplastic Infantile Ganglioglioma
annotated property: has exact synonym
annotated target: Desmoplastic Infantile Ganglioglioma
term-group: SY
term-source: NCI
source-code: TCGA
subsource-name: caDSR

Benign Ovarian Brenner Tumor
type: Class
definition: A benign transitional cell neoplasm that arises from the ovary and is composed of a fibrotic stroma and nests of transitional cells without evidence of atypia. There is no evidence of invasion.
code: C4746
Semantic_Type: Neoplastic Process
Preferred_Name: Benign Ovarian Brenner Tumor
UMLS_CUI: C0474834
Neoplastic_Status: Benign
Legacy_Concept_Name: Benign_Brenner_Tumor
has exact synonym: Benign Brenner Neoplasm of Ovary
has exact synonym: Benign Brenner Neoplasm of the Ovary
has exact synonym: Benign Brenner Tumor of Ovary
has exact synonym: Benign Brenner Tumor of the Ovary
has exact synonym: Benign Ovarian Brenner Neoplasm
has exact synonym: Benign Ovarian Brenner Tumor
in subset: oncotree slim

Axiom
annotated source: Benign Ovarian Brenner Tumor
annotated property: definition
annotated target: A benign transitional cell neoplasm that arises from the ovary and is composed of a fibrotic stroma and nests of transitional cells without evidence of atypia. There is no evidence of invasion.
def-source: NCI

Axiom
annotated source: Benign Ovarian Brenner Tumor
annotated property: has exact synonym
annotated target: Benign Brenner Neoplasm of Ovary
term-group: SY
term-source: NCI

Axiom
annotated source: Benign Ovarian Brenner Tumor
annotated property: has exact synonym
annotated target: Benign Brenner Neoplasm of the Ovary
term-group: SY
term-source: NCI

Axiom
annotated source: Benign Ovarian Brenner Tumor
annotated property: has exact synonym
annotated target: Benign Brenner Tumor of Ovary
term-group: SY
term-source: NCI

Axiom
annotated source: Benign Ovarian Brenner Tumor
annotated property: has exact synonym
annotated target: Benign Brenner Tumor of the Ovary
term-group: SY
term-source: NCI

Axiom
annotated source: Benign Ovarian Brenner Tumor
annotated property: has exact synonym
annotated target: Benign Ovarian Brenner Neoplasm
term-group: SY
term-source: NCI

Axiom
annotated source: Benign Ovarian Brenner Tumor
annotated property: has exact synonym
annotated target: Benign Ovarian Brenner Tumor
term-group: PT
term-source: NCI

Breast Carcinoma with Chondroid Metaplasia
type: Class
subclass of: Mixed Epithelial/Mesenchymal Metaplastic Breast Carcinoma
definition: An invasive carcinoma of the breast showing differentiation towards cartilaginous structures.
code: C47847
Semantic_Type: Neoplastic Process
Preferred_Name: Breast Carcinoma with Chondroid Metaplasia
UMLS_CUI: C1707042
Neoplastic_Status: Malignant
Legacy_Concept_Name: Breast_Carcinoma_with_Chondroid_Metaplasia
has exact synonym: Breast Carcinoma with Cartilaginous Metaplasia
has exact synonym: Breast Carcinoma with Chondroid Metaplasia
in subset: oncotree slim

Axiom
annotated source: Breast Carcinoma with Chondroid Metaplasia
annotated property: definition
annotated target: An invasive carcinoma of the breast showing differentiation towards cartilaginous structures.
def-source: NCI

Axiom
annotated source: Breast Carcinoma with Chondroid Metaplasia
annotated property: has exact synonym
annotated target: Breast Carcinoma with Cartilaginous Metaplasia
term-group: SY
term-source: NCI

Axiom
annotated source: Breast Carcinoma with Chondroid Metaplasia
annotated property: has exact synonym
annotated target: Breast Carcinoma with Chondroid Metaplasia
term-group: PT
term-source: NCI

Breast Carcinoma with Osseous Metaplasia
type: Class
subclass of: Mixed Epithelial/Mesenchymal Metaplastic Breast Carcinoma
definition: An invasive breast carcinoma showing differentiation towards bone structures.
code: C47848
Semantic_Type: Neoplastic Process
Preferred_Name: Breast Carcinoma with Osseous Metaplasia
UMLS_CUI: C1711312
Neoplastic_Status: Malignant
Legacy_Concept_Name: Breast_Carcinoma_with_Osseous_Metaplasia
has exact synonym: Breast Carcinoma with Osseous Metaplasia
in subset: oncotree slim

Axiom
annotated source: Breast Carcinoma with Osseous Metaplasia
annotated property: definition
annotated target: An invasive breast carcinoma showing differentiation towards bone structures.
def-source: NCI

Axiom
annotated source: Breast Carcinoma with Osseous Metaplasia
annotated property: has exact synonym
annotated target: Breast Carcinoma with Osseous Metaplasia
term-group: PT
term-source: NCI

Malignant Odontogenic Neoplasm
type: Class
definition: A rare neoplasm arising from tooth-forming tissues. It occurs in the maxillofacial skeleton or the gingiva. Symptoms include swelling, pain, bleeding, mobility of affected teeth, and oral mucosa ulcerations. It may metastasize to lymph nodes and distant anatomic sites early.
Concept_In_Subset: NCIT C118168
Concept_In_Subset: NCIT C61410
Concept_In_Subset: NCIT C77526
Concept_In_Subset: NCIT C88025
code: C4812
Semantic_Type: Neoplastic Process
Display_Name: Malignant Odontogenic Neoplasm
Preferred_Name: Malignant Odontogenic Neoplasm
UMLS_CUI: C0334558
Contributing_Source: CDISC
Contributing_Source: CTRP
ALT_DEFINITION: A malignant neoplasm of tooth origin.
ICD-O-3_Code: 9270/3
ICD-O-3_Code: 9342/3
Neoplastic_Status: Malignant
Legacy_Concept_Name: Malignant_Odontogenic_Neoplasm
has exact synonym: Malignant Odontogenic Neoplasm
has exact synonym: Malignant Odontogenic Tumor
has exact synonym: ODONTOMA, MALIGNANT
has exact synonym: Odontogenic Carcinoma
has exact synonym: Odontogenic Carcinosarcoma
in subset: oncotree slim

Axiom
annotated source: Malignant Odontogenic Neoplasm
annotated property: definition
annotated target: A rare neoplasm arising from tooth-forming tissues. It occurs in the maxillofacial skeleton or the gingiva. Symptoms include swelling, pain, bleeding, mobility of affected teeth, and oral mucosa ulcerations. It may metastasize to lymph nodes and distant anatomic sites early.
def-source: NCI

Axiom
annotated source: Malignant Odontogenic Neoplasm
annotated property: ALT_DEFINITION
annotated target: A malignant neoplasm of tooth origin.
def-source: CDISC

Axiom
annotated source: Malignant Odontogenic Neoplasm
annotated property: has exact synonym
annotated target: Malignant Odontogenic Neoplasm
term-group: PT
term-source: NCI

Axiom
annotated source: Malignant Odontogenic Neoplasm
annotated property: has exact synonym
annotated target: Malignant Odontogenic Tumor
term-group: SY
term-source: CDISC

Axiom
annotated source: Malignant Odontogenic Neoplasm
annotated property: has exact synonym
annotated target: Malignant Odontogenic Tumor
term-group: SY
term-source: NCI

Axiom
annotated source: Malignant Odontogenic Neoplasm
annotated property: has exact synonym
annotated target: ODONTOMA, MALIGNANT
term-group: PT
term-source: CDISC

Axiom
annotated source: Malignant Odontogenic Neoplasm
annotated property: has exact synonym
annotated target: Odontogenic Carcinoma
term-group: SY
term-source: CDISC

Axiom
annotated source: Malignant Odontogenic Neoplasm
annotated property: has exact synonym
annotated target: Odontogenic Carcinoma
term-group: SY
term-source: NCI

Axiom
annotated source: Malignant Odontogenic Neoplasm
annotated property: has exact synonym
annotated target: Odontogenic Carcinosarcoma
term-group: SY
term-source: CDISC

Axiom
annotated source: Malignant Odontogenic Neoplasm
annotated property: has exact synonym
annotated target: Odontogenic Carcinosarcoma
term-group: SY
term-source: NCI

Ewing Sarcoma
type: Class
definition: A small round cell tumor that lacks morphologic, immunohistochemical, and electron microscopic evidence of neuroectodermal differentiation. It represents one of the two ends of the spectrum called Ewing sarcoma/peripheral neuroectodermal tumor. It affects mostly males under age 20, and it can occur in soft tissue or bone. Pain and the presence of a mass are the most common clinical symptoms.
Has_NICHD_Parent: NCIT C9118
Concept_In_Subset: NCIT C116977
Concept_In_Subset: NCIT C118464
Concept_In_Subset: NCIT C126659
Concept_In_Subset: NCIT C90259
code: C4817
Semantic_Type: Neoplastic Process
Display_Name: Ewing Sarcoma
Preferred_Name: Ewing Sarcoma
UMLS_CUI: C0553580
Contributing_Source: CTRP
Contributing_Source: MedDRA
Contributing_Source: NICHD
ALT_DEFINITION: A malignant neoplasm of the bone, or the soft tissue adjacent to bone, that is comprised of primitive neuroectodermal cells.
ALT_DEFINITION: A type of cancer that forms in bone or soft tissue.
ICD-O-3_Code: 9260/3
Neoplastic_Status: Malignant
Legacy_Concept_Name: Ewing_s_Sarcoma
NICHD_Hierarchy_Term: Ewing Sarcoma
has exact synonym: ES
has exact synonym: Ewing Sarcoma
has exact synonym: Ewing sarcoma
has exact synonym: Ewing's Sarcoma
has exact synonym: Ewing's Tumor
in subset: oncotree slim

Axiom
annotated source: Ewing Sarcoma
annotated property: definition
annotated target: A small round cell tumor that lacks morphologic, immunohistochemical, and electron microscopic evidence of neuroectodermal differentiation. It represents one of the two ends of the spectrum called Ewing sarcoma/peripheral neuroectodermal tumor. It affects mostly males under age 20, and it can occur in soft tissue or bone. Pain and the presence of a mass are the most common clinical symptoms.
def-source: NCI

Axiom
annotated source: Ewing Sarcoma
annotated property: ALT_DEFINITION
annotated target: A malignant neoplasm of the bone, or the soft tissue adjacent to bone, that is comprised of primitive neuroectodermal cells.
def-source: NICHD

Axiom
annotated source: Ewing Sarcoma
annotated property: ALT_DEFINITION
annotated target: A type of cancer that forms in bone or soft tissue.
def-source: NCI-GLOSS

Axiom
annotated source: Ewing Sarcoma
annotated property: has exact synonym
annotated target: ES
term-group: SY
term-source: NCI

Axiom
annotated source: Ewing Sarcoma
annotated property: has exact synonym
annotated target: Ewing Sarcoma
term-group: PT
term-source: CTRP

Axiom
annotated source: Ewing Sarcoma
annotated property: has exact synonym
annotated target: Ewing Sarcoma
term-group: PT
term-source: NCI

Axiom
annotated source: Ewing Sarcoma
annotated property: has exact synonym
annotated target: Ewing Sarcoma
term-group: PT
term-source: NICHD

Axiom
annotated source: Ewing Sarcoma
annotated property: has exact synonym
annotated target: Ewing sarcoma
term-group: PT
term-source: NCI-GLOSS
source-code: CDR0000046031

Axiom
annotated source: Ewing Sarcoma
annotated property: has exact synonym
annotated target: Ewing's Sarcoma
term-group: SY
term-source: NCI

Axiom
annotated source: Ewing Sarcoma
annotated property: has exact synonym
annotated target: Ewing's Tumor
term-group: SY
term-source: NCI

Skin Squamous Cell Carcinoma
type: Class
definition: A carcinoma arising from the squamous cells of the epidermis. Skin squamous cell carcinoma is most commonly found on sun-exposed areas. The majority of the tumors are well-differentiated.
Concept_In_Subset: NCIT C102905
Concept_In_Subset: NCIT C103116
Concept_In_Subset: NCIT C116977
Concept_In_Subset: NCIT C126659
code: C4819
Semantic_Type: Neoplastic Process
Display_Name: Skin Squamous Cell Cancer
Preferred_Name: Skin Squamous Cell Carcinoma
UMLS_CUI: C0553723
Contributing_Source: CTEP
Contributing_Source: CTRP
Neoplastic_Status: Malignant
Legacy_Concept_Name: Skin_Squamous_Cell_Carcinoma
has exact synonym: Cutaneous Squamous Cell Carcinoma
has exact synonym: Epidermoid Carcinoma of Skin
has exact synonym: Epidermoid Carcinoma of the Skin
has exact synonym: Epidermoid Skin Carcinoma
has exact synonym: Skin Squamous Cell Cancer
has exact synonym: Skin Squamous Cell Carcinoma
has exact synonym: Squamous Cell Carcinoma of Skin
has exact synonym: Squamous Cell Carcinoma of the Skin
has exact synonym: Squamous Cell Skin Carcinoma
has exact synonym: Squamous cell carcinoma - skin
has exact synonym: Squamous cell carcinoma of the skin
in subset: oncotree slim

Axiom
annotated source: Skin Squamous Cell Carcinoma
annotated property: definition
annotated target: A carcinoma arising from the squamous cells of the epidermis. Skin squamous cell carcinoma is most commonly found on sun-exposed areas. The majority of the tumors are well-differentiated.
def-source: NCI

Axiom
annotated source: Skin Squamous Cell Carcinoma
annotated property: has exact synonym
annotated target: Cutaneous Squamous Cell Carcinoma
term-group: SY
term-source: NCI

Axiom
annotated source: Skin Squamous Cell Carcinoma
annotated property: has exact synonym
annotated target: Epidermoid Carcinoma of Skin
term-group: SY
term-source: NCI

Axiom
annotated source: Skin Squamous Cell Carcinoma
annotated property: has exact synonym
annotated target: Epidermoid Carcinoma of the Skin
term-group: SY
term-source: NCI

Axiom
annotated source: Skin Squamous Cell Carcinoma
annotated property: has exact synonym
annotated target: Epidermoid Skin Carcinoma
term-group: SY
term-source: NCI

Axiom
annotated source: Skin Squamous Cell Carcinoma
annotated property: has exact synonym
annotated target: Skin Squamous Cell Cancer
term-group: DN
term-source: CTRP

Axiom
annotated source: Skin Squamous Cell Carcinoma
annotated property: has exact synonym
annotated target: Skin Squamous Cell Carcinoma
term-group: PT
term-source: NCI

Axiom
annotated source: Skin Squamous Cell Carcinoma
annotated property: has exact synonym
annotated target: Squamous Cell Carcinoma of Skin
term-group: SY
term-source: NCI

Axiom
annotated source: Skin Squamous Cell Carcinoma
annotated property: has exact synonym
annotated target: Squamous Cell Carcinoma of the Skin
term-group: SY
term-source: NCI

Axiom
annotated source: Skin Squamous Cell Carcinoma
annotated property: has exact synonym
annotated target: Squamous Cell Skin Carcinoma
term-group: SY
term-source: NCI

Axiom
annotated source: Skin Squamous Cell Carcinoma
annotated property: has exact synonym
annotated target: Squamous cell carcinoma - skin
term-group: SY
term-source: CTEP
source-code: 10041834
subsource-name: SDC

Axiom
annotated source: Skin Squamous Cell Carcinoma
annotated property: has exact synonym
annotated target: Squamous cell carcinoma of the skin
term-group: PT
term-source: CTEP
source-code: 10041834
subsource-name: SDC

Oral Cavity Squamous Cell Carcinoma
type: Class
definition: A squamous cell carcinoma arising from the oral cavity. It affects predominantly adults in their fifth and sixth decades of life and is associated with alcohol and tobacco use. Human papillomavirus is present in approximately half of the cases. It is characterized by a tendency to metastasize early to the lymph nodes. When the tumor is small, patients are often asymptomatic. Physical examination may reveal erythematous or white lesions or plaques. The majority of patients present with signs and symptoms of locally advanced disease including mucosal ulceration, pain, difficulty with speaking, chewing, and swallowing, bleeding, weight loss, and neck swelling. Patients may also present with swollen neck lymph nodes without any symptoms from the oropharyngeal tumor. The most significant prognostic factors are the size of the tumor and the lymph nodes status.
Concept_In_Subset: NCIT C126659
code: C4833
Semantic_Type: Neoplastic Process
Preferred_Name: Oral Cavity Squamous Cell Carcinoma
UMLS_CUI: C0585362
Neoplastic_Status: Malignant
Legacy_Concept_Name: Oral_Cavity_Squamous_Cell_Carcinoma
has exact synonym: Mouth SCC
has exact synonym: Mouth Squamous Cell Carcinoma
has exact synonym: Oral Cavity SCC
has exact synonym: Oral Cavity Squamous Cell Cancer
has exact synonym: Oral Cavity Squamous Cell Carcinoma
has exact synonym: SCC of Mouth
has exact synonym: SCC of Oral Cavity
has exact synonym: SCC of the Mouth
has exact synonym: SCC of the Oral Cavity
has exact synonym: Squamous Cell Carcinoma of Mouth
has exact synonym: Squamous Cell Carcinoma of Oral Cavity
has exact synonym: Squamous Cell Carcinoma of the Mouth
has exact synonym: Squamous Cell Carcinoma of the Oral Cavity
in subset: oncotree slim

Axiom
annotated source: Oral Cavity Squamous Cell Carcinoma
annotated property: definition
annotated target: A squamous cell carcinoma arising from the oral cavity. It affects predominantly adults in their fifth and sixth decades of life and is associated with alcohol and tobacco use. Human papillomavirus is present in approximately half of the cases. It is characterized by a tendency to metastasize early to the lymph nodes. When the tumor is small, patients are often asymptomatic. Physical examination may reveal erythematous or white lesions or plaques. The majority of patients present with signs and symptoms of locally advanced disease including mucosal ulceration, pain, difficulty with speaking, chewing, and swallowing, bleeding, weight loss, and neck swelling. Patients may also present with swollen neck lymph nodes without any symptoms from the oropharyngeal tumor. The most significant prognostic factors are the size of the tumor and the lymph nodes status.
def-source: NCI

Axiom
annotated source: Oral Cavity Squamous Cell Carcinoma
annotated property: has exact synonym
annotated target: Mouth SCC
term-group: SY
term-source: NCI

Axiom
annotated source: Oral Cavity Squamous Cell Carcinoma
annotated property: has exact synonym
annotated target: Mouth Squamous Cell Carcinoma
term-group: SY
term-source: NCI

Axiom
annotated source: Oral Cavity Squamous Cell Carcinoma
annotated property: has exact synonym
annotated target: Oral Cavity SCC
term-group: SY
term-source: NCI

Axiom
annotated source: Oral Cavity Squamous Cell Carcinoma
annotated property: has exact synonym
annotated target: Oral Cavity Squamous Cell Cancer
term-group: DN
term-source: CTRP

Axiom
annotated source: Oral Cavity Squamous Cell Carcinoma
annotated property: has exact synonym
annotated target: Oral Cavity Squamous Cell Carcinoma
term-group: PT
term-source: NCI

Axiom
annotated source: Oral Cavity Squamous Cell Carcinoma
annotated property: has exact synonym
annotated target: SCC of Mouth
term-group: SY
term-source: NCI

Axiom
annotated source: Oral Cavity Squamous Cell Carcinoma
annotated property: has exact synonym
annotated target: SCC of Oral Cavity
term-group: SY
term-source: NCI

Axiom
annotated source: Oral Cavity Squamous Cell Carcinoma
annotated property: has exact synonym
annotated target: SCC of the Mouth
term-group: SY
term-source: NCI

Axiom
annotated source: Oral Cavity Squamous Cell Carcinoma
annotated property: has exact synonym
annotated target: SCC of the Oral Cavity
term-group: SY
term-source: NCI

Axiom
annotated source: Oral Cavity Squamous Cell Carcinoma
annotated property: has exact synonym
annotated target: Squamous Cell Carcinoma of Mouth
term-group: SY
term-source: NCI

Axiom
annotated source: Oral Cavity Squamous Cell Carcinoma
annotated property: has exact synonym
annotated target: Squamous Cell Carcinoma of Oral Cavity
term-group: SY
term-source: NCI

Axiom
annotated source: Oral Cavity Squamous Cell Carcinoma
annotated property: has exact synonym
annotated target: Squamous Cell Carcinoma of the Mouth
term-group: SY
term-source: NCI

Axiom
annotated source: Oral Cavity Squamous Cell Carcinoma
annotated property: has exact synonym
annotated target: Squamous Cell Carcinoma of the Oral Cavity
term-group: SY
term-source: NCI

Acute Monocytic Leukemia
type: Class
definition: An acute myeloid leukemia in which the majority of monocytic cells are promonocytes. (WHO, 2001)
Concept_In_Subset: NCIT C126659
Concept_In_Subset: NCIT C61410
Concept_In_Subset: NCIT C77526
Concept_In_Subset: NCIT C88025
code: C4861
Semantic_Type: Neoplastic Process
Preferred_Name: Acute Monocytic Leukemia
UMLS_CUI: C0023465
Contributing_Source: CDISC
ALT_DEFINITION: A progressive, proliferative disease of blood cells, originating from immature monocytes.
ICD-O-3_Code: 9891/3
Neoplastic_Status: Malignant
Legacy_Concept_Name: Monocytic_Leukemia
has exact synonym: Acute Monocytic Leukemia
has exact synonym: Acute Monocytic Leukemia (FAB M5b)
has exact synonym: Acute Monocytic Leukemia (Fab M5B)
has exact synonym: LEUKEMIA, MONOCYTIC, MALIGNANT
has exact synonym: Monocytic Leukemia
in subset: oncotree slim

Axiom
annotated source: Acute Monocytic Leukemia
annotated property: definition
annotated target: An acute myeloid leukemia in which the majority of monocytic cells are promonocytes. (WHO, 2001)
def-source: NCI

Axiom
annotated source: Acute Monocytic Leukemia
annotated property: ALT_DEFINITION
annotated target: A progressive, proliferative disease of blood cells, originating from immature monocytes.
def-source: CDISC

Axiom
annotated source: Acute Monocytic Leukemia
annotated property: has exact synonym
annotated target: Acute Monocytic Leukemia
term-group: PT
term-source: NCI

Axiom
annotated source: Acute Monocytic Leukemia
annotated property: has exact synonym
annotated target: Acute Monocytic Leukemia (FAB M5b)
term-group: SY
term-source: NCI

Axiom
annotated source: Acute Monocytic Leukemia
annotated property: has exact synonym
annotated target: Acute Monocytic Leukemia (Fab M5B)
term-group: SY
term-source: CDISC

Axiom
annotated source: Acute Monocytic Leukemia
annotated property: has exact synonym
annotated target: LEUKEMIA, MONOCYTIC, MALIGNANT
term-group: PT
term-source: CDISC

Axiom
annotated source: Acute Monocytic Leukemia
annotated property: has exact synonym
annotated target: Monocytic Leukemia
term-group: SY
term-source: CDISC

Axiom
annotated source: Acute Monocytic Leukemia
annotated property: has exact synonym
annotated target: Monocytic Leukemia
term-group: SY
term-source: NCI

Complete Hydatidiform Mole
type: Class
subclass of: Hydatidiform Mole
definition: A gestational trophoblastic disorder in which there is no embryo or normal placental tissue and the chorionic villi are hydropic.
Has_NICHD_Parent: Hydatidiform Mole
Concept_In_Subset: NCIT C118466
Concept_In_Subset: NCIT C90259
code: C4871
Semantic_Type: Disease or Syndrome
Preferred_Name: Complete Hydatidiform Mole
UMLS_CUI: C0678213
Contributing_Source: NICHD
ALT_DEFINITION: A placental disorder where the majority of the chorionic villi are hydropic.
Legacy_Concept_Name: Complete_Hydatidiform_Mole
NICHD_Hierarchy_Term: Complete Hydatidiform Mole
has exact synonym: Classical Hydatidiform Mole
has exact synonym: Complete Hydatid Mole
has exact synonym: Complete Hydatidiform Mole
has exact synonym: Complete Molar Pregnancy
has exact synonym: Complete Mole
in subset: oncotree slim

Axiom
annotated source: Complete Hydatidiform Mole
annotated property: definition
annotated target: A gestational trophoblastic disorder in which there is no embryo or normal placental tissue and the chorionic villi are hydropic.
def-source: NCI
attr: NICHD

Axiom
annotated source: Complete Hydatidiform Mole
annotated property: ALT_DEFINITION
annotated target: A placental disorder where the majority of the chorionic villi are hydropic.
def-source: NICHD

Axiom
annotated source: Complete Hydatidiform Mole
annotated property: has exact synonym
annotated target: Classical Hydatidiform Mole
term-group: SY
term-source: NICHD

Axiom
annotated source: Complete Hydatidiform Mole
annotated property: has exact synonym
annotated target: Complete Hydatid Mole
term-group: SY
term-source: NCI

Axiom
annotated source: Complete Hydatidiform Mole
annotated property: has exact synonym
annotated target: Complete Hydatidiform Mole
term-group: PT
term-source: NCI

Axiom
annotated source: Complete Hydatidiform Mole
annotated property: has exact synonym
annotated target: Complete Hydatidiform Mole
term-group: PT
term-source: NICHD

Axiom
annotated source: Complete Hydatidiform Mole
annotated property: has exact synonym
annotated target: Complete Molar Pregnancy
term-group: SY
term-source: NCI

Axiom
annotated source: Complete Hydatidiform Mole
annotated property: has exact synonym
annotated target: Complete Mole
term-group: SY
term-source: NCI

Dedifferentiated Chordoma
type: Class
subclass of: Chordoma
definition: A high-grade malignant bone tumor arising from the remnants of the notochord. It is characterized by a lobulated growth pattern, myxoid stroma formation, the presence of physaliphorous cells, and a sarcomatous component.
Concept_In_Subset: NCIT C126659
code: C48876
Semantic_Type: Neoplastic Process
Preferred_Name: Dedifferentiated Chordoma
UMLS_CUI: C1266174
ICD-O-3_Code: 9372/3
Neoplastic_Status: Malignant
Legacy_Concept_Name: Dedifferentiated_Chordoma
has exact synonym: Dedifferentiated Chordoma
has exact synonym: Sarcomatoid Chordoma
in subset: oncotree slim

Axiom
annotated source: Dedifferentiated Chordoma
annotated property: definition
annotated target: A high-grade malignant bone tumor arising from the remnants of the notochord. It is characterized by a lobulated growth pattern, myxoid stroma formation, the presence of physaliphorous cells, and a sarcomatous component.
def-source: NCI

Axiom
annotated source: Dedifferentiated Chordoma
annotated property: has exact synonym
annotated target: Dedifferentiated Chordoma
term-group: PT
term-source: NCI

Axiom
annotated source: Dedifferentiated Chordoma
annotated property: has exact synonym
annotated target: Sarcomatoid Chordoma
term-group: SY
term-source: NCI

Ovarian Carcinoma
type: Class
definition: A malignant neoplasm originating from the surface ovarian epithelium. It accounts for the greatest number of deaths from malignancies of the female genital tract and is the fifth leading cause of cancer fatalities in women. It is predominantly a disease of older white women of northern European extraction, but it is seen in all ages and ethnic groups. Adenocarcinomas constitute the vast majority of ovarian carcinomas. The pattern of metastatic spread in ovarian carcinoma is similar regardless of the microscopic type. The most common sites of involvement are the contralateral ovary, peritoneal cavity, para-aortic and pelvic lymph nodes, and liver. Lung and pleura are the most common sites of extra-abdominal spread. The primary form of therapy is surgical. The overall prognosis of ovarian carcinoma remains poor, a direct result of its rapid growth rate and the lack of early symptoms. --2002
Concept_In_Subset: NCIT C102905
Concept_In_Subset: NCIT C103102
Concept_In_Subset: NCIT C116977
Concept_In_Subset: NCIT C126659
code: C4908
Semantic_Type: Neoplastic Process
Display_Name: Ovarian Epithelial Cancer
Preferred_Name: Ovarian Carcinoma
UMLS_CUI: C0677886
Contributing_Source: CTEP
Contributing_Source: CTRP
ALT_DEFINITION: Cancer that occurs in the cells lining the ovaries.
Neoplastic_Status: Malignant
Legacy_Concept_Name: Ovarian_Carcinoma
has exact synonym: Carcinoma of Ovary
has exact synonym: Carcinoma of the Ovary
has exact synonym: Epithelial Ovarian Cancer
has exact synonym: Ovarian Cancer
has exact synonym: Ovarian Carcinoma
has exact synonym: Ovarian Epithelial Cancer
has exact synonym: Ovarian epithelial cancer
has exact synonym: epithelial ovarian cancer
has exact synonym: ovarian epithelial cancer
in subset: oncotree slim

Axiom
annotated source: Ovarian Carcinoma
annotated property: definition
annotated target: A malignant neoplasm originating from the surface ovarian epithelium. It accounts for the greatest number of deaths from malignancies of the female genital tract and is the fifth leading cause of cancer fatalities in women. It is predominantly a disease of older white women of northern European extraction, but it is seen in all ages and ethnic groups. Adenocarcinomas constitute the vast majority of ovarian carcinomas. The pattern of metastatic spread in ovarian carcinoma is similar regardless of the microscopic type. The most common sites of involvement are the contralateral ovary, peritoneal cavity, para-aortic and pelvic lymph nodes, and liver. Lung and pleura are the most common sites of extra-abdominal spread. The primary form of therapy is surgical. The overall prognosis of ovarian carcinoma remains poor, a direct result of its rapid growth rate and the lack of early symptoms. --2002
def-source: NCI

Axiom
annotated source: Ovarian Carcinoma
annotated property: ALT_DEFINITION
annotated target: Cancer that occurs in the cells lining the ovaries.
def-source: NCI-GLOSS

Axiom
annotated source: Ovarian Carcinoma
annotated property: has exact synonym
annotated target: Carcinoma of Ovary
term-group: SY
term-source: NCI

Axiom
annotated source: Ovarian Carcinoma
annotated property: has exact synonym
annotated target: Carcinoma of the Ovary
term-group: SY
term-source: NCI

Axiom
annotated source: Ovarian Carcinoma
annotated property: has exact synonym
annotated target: Epithelial Ovarian Cancer
term-group: AQS
term-source: NCI

Axiom
annotated source: Ovarian Carcinoma
annotated property: has exact synonym
annotated target: Ovarian Cancer
term-group: DN
term-source: CTRP

Axiom
annotated source: Ovarian Carcinoma
annotated property: has exact synonym
annotated target: Ovarian Carcinoma
term-group: PT
term-source: NCI

Axiom
annotated source: Ovarian Carcinoma
annotated property: has exact synonym
annotated target: Ovarian Carcinoma
term-group: SY
term-source: CTRP

Axiom
annotated source: Ovarian Carcinoma
annotated property: has exact synonym
annotated target: Ovarian Carcinoma
term-group: SY
term-source: NCI
source-code: TCGA
subsource-name: caDSR

Axiom
annotated source: Ovarian Carcinoma
annotated property: has exact synonym
annotated target: Ovarian Epithelial Cancer
term-group: PT
term-source: CTRP

Axiom
annotated source: Ovarian Carcinoma
annotated property: has exact synonym
annotated target: Ovarian epithelial cancer
term-group: PT
term-source: CTEP
source-code: 10033159
subsource-name: SDC

Axiom
annotated source: Ovarian Carcinoma
annotated property: has exact synonym
annotated target: epithelial ovarian cancer
term-group: PT
term-source: NCI-GLOSS
source-code: CDR0000045683

Axiom
annotated source: Ovarian Carcinoma
annotated property: has exact synonym
annotated target: ovarian epithelial cancer
term-group: PT
term-source: NCI-GLOSS
source-code: CDR0000046768

Small Cell Lung Carcinoma
type: Class
definition: A highly aggressive subtype of lung carcinoma characterized by the presence of malignant small cells and necrosis. Metastatic disease is usually present at the time of diagnosis.
Concept_In_Subset: NCIT C102905
Concept_In_Subset: NCIT C103091
Concept_In_Subset: NCIT C116977
Concept_In_Subset: NCIT C126659
code: C4917
Semantic_Type: Neoplastic Process
Display_Name: Small Cell Lung Cancer
Preferred_Name: Small Cell Lung Carcinoma
UMLS_CUI: C0149925
Contributing_Source: CTEP
Contributing_Source: CTRP
ALT_DEFINITION: An aggressive (fast-growing) cancer that forms in tissues of the lung and can spread to other parts of the body. The cancer cells look small and oval-shaped when looked at under a microscope.
Neoplastic_Status: Malignant
Legacy_Concept_Name: Small_Cell_Lung_Carcinoma
has exact synonym: Lung Oat Cell Carcinoma
has exact synonym: Lung Small Cell Neuroendocrine Carcinoma
has exact synonym: Oat Cell Carcinoma of Lung
has exact synonym: Oat Cell Carcinoma of the Lung
has exact synonym: Oat Cell Lung Carcinoma
has exact synonym: SCLC
has exact synonym: Small Cell Carcinoma of Lung
has exact synonym: Small Cell Carcinoma of the Lung
has exact synonym: Small Cell Lung Cancer
has exact synonym: Small Cell Lung Carcinoma
has exact synonym: Small Cell Neuroendocrine Carcinoma of Lung
has exact synonym: Small Cell Neuroendocrine Carcinoma of the Lung
has exact synonym: Small cell lung cancer
has exact synonym: small cell lung cancer
in subset: oncotree slim

Axiom
annotated source: Small Cell Lung Carcinoma
annotated property: definition
annotated target: A highly aggressive subtype of lung carcinoma characterized by the presence of malignant small cells and necrosis. Metastatic disease is usually present at the time of diagnosis.
def-source: NCI

Axiom
annotated source: Small Cell Lung Carcinoma
annotated property: ALT_DEFINITION
annotated target: An aggressive (fast-growing) cancer that forms in tissues of the lung and can spread to other parts of the body. The cancer cells look small and oval-shaped when looked at under a microscope.
def-source: NCI-GLOSS

Axiom
annotated source: Small Cell Lung Carcinoma
annotated property: has exact synonym
annotated target: Lung Oat Cell Carcinoma
term-group: AQS
term-source: NCI

Axiom
annotated source: Small Cell Lung Carcinoma
annotated property: has exact synonym
annotated target: Lung Small Cell Neuroendocrine Carcinoma
term-group: SY
term-source: NCI

Axiom
annotated source: Small Cell Lung Carcinoma
annotated property: has exact synonym
annotated target: Oat Cell Carcinoma of Lung
term-group: AQS
term-source: NCI

Axiom
annotated source: Small Cell Lung Carcinoma
annotated property: has exact synonym
annotated target: Oat Cell Carcinoma of the Lung
term-group: AQS
term-source: NCI

Axiom
annotated source: Small Cell Lung Carcinoma
annotated property: has exact synonym
annotated target: Oat Cell Lung Carcinoma
term-group: AQS
term-source: NCI

Axiom
annotated source: Small Cell Lung Carcinoma
annotated property: has exact synonym
annotated target: SCLC
term-group: AB
term-source: NCI

Axiom
annotated source: Small Cell Lung Carcinoma
annotated property: has exact synonym
annotated target: Small Cell Carcinoma of Lung
term-group: SY
term-source: NCI

Axiom
annotated source: Small Cell Lung Carcinoma
annotated property: has exact synonym
annotated target: Small Cell Carcinoma of the Lung
term-group: SY
term-source: NCI

Axiom
annotated source: Small Cell Lung Carcinoma
annotated property: has exact synonym
annotated target: Small Cell Lung Cancer
term-group: DN
term-source: CTRP

Axiom
annotated source: Small Cell Lung Carcinoma
annotated property: has exact synonym
annotated target: Small Cell Lung Cancer
term-group: SY
term-source: NCI

Axiom
annotated source: Small Cell Lung Carcinoma
annotated property: has exact synonym
annotated target: Small Cell Lung Carcinoma
term-group: PT
term-source: NCI

Axiom
annotated source: Small Cell Lung Carcinoma
annotated property: has exact synonym
annotated target: Small Cell Neuroendocrine Carcinoma of Lung
term-group: SY
term-source: NCI

Axiom
annotated source: Small Cell Lung Carcinoma
annotated property: has exact synonym
annotated target: Small Cell Neuroendocrine Carcinoma of the Lung
term-group: SY
term-source: NCI

Axiom
annotated source: Small Cell Lung Carcinoma
annotated property: has exact synonym
annotated target: Small cell lung cancer
term-group: PT
term-source: CTEP
source-code: 10041071
subsource-name: SDC

Axiom
annotated source: Small Cell Lung Carcinoma
annotated property: has exact synonym
annotated target: small cell lung cancer
term-group: PT
term-source: NCI-GLOSS
source-code: CDR0000045327

Sella Turcica Neoplasm
type: Class
definition: A benign or malignant neoplasm that occurs in sella turcica. Representative examples include craniopharyngioma and pituitary gland adenoma.
code: C4944
Semantic_Type: Neoplastic Process
Preferred_Name: Sella Turcica Neoplasm
UMLS_CUI: C0748616
Neoplastic_Status: Undetermined
Legacy_Concept_Name: Sella_Turcica_Neoplasm
has exact synonym: Neoplasm of Sella Turcica
has exact synonym: Neoplasm of the Sella Turcica
has exact synonym: Sella Turcica Neoplasm
has exact synonym: Sella Turcica Tumor
has exact synonym: Sellar Neoplasm
has exact synonym: Sellar Tumor
has exact synonym: Tumor of Sella Turcica
has exact synonym: Tumor of the Sella Turcica
in subset: oncotree slim

Axiom
annotated source: Sella Turcica Neoplasm
annotated property: definition
annotated target: A benign or malignant neoplasm that occurs in sella turcica. Representative examples include craniopharyngioma and pituitary gland adenoma.
def-source: NCI

Axiom
annotated source: Sella Turcica Neoplasm
annotated property: has exact synonym
annotated target: Neoplasm of Sella Turcica
term-group: SY
term-source: NCI

Axiom
annotated source: Sella Turcica Neoplasm
annotated property: has exact synonym
annotated target: Neoplasm of the Sella Turcica
term-group: SY
term-source: NCI

Axiom
annotated source: Sella Turcica Neoplasm
annotated property: has exact synonym
annotated target: Sella Turcica Neoplasm
term-group: PT
term-source: NCI

Axiom
annotated source: Sella Turcica Neoplasm
annotated property: has exact synonym
annotated target: Sella Turcica Tumor
term-group: SY
term-source: NCI

Axiom
annotated source: Sella Turcica Neoplasm
annotated property: has exact synonym
annotated target: Sellar Neoplasm
term-group: SY
term-source: NCI

Axiom
annotated source: Sella Turcica Neoplasm
annotated property: has exact synonym
annotated target: Sellar Tumor
term-group: SY
term-source: NCI

Axiom
annotated source: Sella Turcica Neoplasm
annotated property: has exact synonym
annotated target: Tumor of Sella Turcica
term-group: SY
term-source: NCI

Axiom
annotated source: Sella Turcica Neoplasm
annotated property: has exact synonym
annotated target: Tumor of the Sella Turcica
term-group: SY
term-source: NCI

Thyroid Gland Oncocytic Follicular Carcinoma
type: Class
subclass of: NCIT C8054
definition: A follicular carcinoma of the thyroid gland, characterized by the presence of large cells with eosinophilic granular cytoplasm and pleomorphic nuclei with prominent, eosinophilic nucleoli. The nuclear features that characterize the papillary carcinomas of the thyroid gland are absent.
code: C4946
Semantic_Type: Neoplastic Process
Preferred_Name: Thyroid Gland Oncocytic Follicular Carcinoma
UMLS_CUI: C0749424
Neoplastic_Status: Malignant
Legacy_Concept_Name: Thyroid_Hurthle_Cell_Carcinoma
has exact synonym: Hurthle Cell Carcinoma of Thyroid
has exact synonym: Hurthle Cell Carcinoma of Thyroid Gland
has exact synonym: Hurthle Cell Carcinoma of the Thyroid
has exact synonym: Hurthle Cell Carcinoma of the Thyroid Gland
has exact synonym: Hurthle Cell Thyroid Gland Carcinoma
has exact synonym: Oncocytic Carcinoma of Thyroid
has exact synonym: Oncocytic Carcinoma of the Thyroid
has exact synonym: Thyroid Gland Hurthle Cell Carcinoma
has exact synonym: Thyroid Gland Oncocytic Follicular Carcinoma
has exact synonym: Thyroid Hurthle Cell Carcinoma
has exact synonym: Thyroid Oncocytic Carcinoma
in subset: oncotree slim

Axiom
annotated source: Thyroid Gland Oncocytic Follicular Carcinoma
annotated property: definition
annotated target: A follicular carcinoma of the thyroid gland, characterized by the presence of large cells with eosinophilic granular cytoplasm and pleomorphic nuclei with prominent, eosinophilic nucleoli. The nuclear features that characterize the papillary carcinomas of the thyroid gland are absent.
def-source: NCI

Axiom
annotated source: Thyroid Gland Oncocytic Follicular Carcinoma
annotated property: has exact synonym
annotated target: Hurthle Cell Carcinoma of Thyroid
term-group: SY
term-source: NCI

Axiom
annotated source: Thyroid Gland Oncocytic Follicular Carcinoma
annotated property: has exact synonym
annotated target: Hurthle Cell Carcinoma of Thyroid Gland
term-group: SY
term-source: NCI

Axiom
annotated source: Thyroid Gland Oncocytic Follicular Carcinoma
annotated property: has exact synonym
annotated target: Hurthle Cell Carcinoma of the Thyroid
term-group: SY
term-source: NCI

Axiom
annotated source: Thyroid Gland Oncocytic Follicular Carcinoma
annotated property: has exact synonym
annotated target: Hurthle Cell Carcinoma of the Thyroid Gland
term-group: SY
term-source: NCI

Axiom
annotated source: Thyroid Gland Oncocytic Follicular Carcinoma
annotated property: has exact synonym
annotated target: Hurthle Cell Thyroid Gland Carcinoma
term-group: SY
term-source: NCI

Axiom
annotated source: Thyroid Gland Oncocytic Follicular Carcinoma
annotated property: has exact synonym
annotated target: Oncocytic Carcinoma of Thyroid
term-group: SY
term-source: NCI

Axiom
annotated source: Thyroid Gland Oncocytic Follicular Carcinoma
annotated property: has exact synonym
annotated target: Oncocytic Carcinoma of the Thyroid
term-group: SY
term-source: NCI

Axiom
annotated source: Thyroid Gland Oncocytic Follicular Carcinoma
annotated property: has exact synonym
annotated target: Thyroid Gland Hurthle Cell Carcinoma
term-group: SY
term-source: NCI

Axiom
annotated source: Thyroid Gland Oncocytic Follicular Carcinoma
annotated property: has exact synonym
annotated target: Thyroid Gland Oncocytic Follicular Carcinoma
term-group: PT
term-source: NCI

Axiom
annotated source: Thyroid Gland Oncocytic Follicular Carcinoma
annotated property: has exact synonym
annotated target: Thyroid Hurthle Cell Carcinoma
term-group: SY
term-source: NCI

Axiom
annotated source: Thyroid Gland Oncocytic Follicular Carcinoma
annotated property: has exact synonym
annotated target: Thyroid Oncocytic Carcinoma
term-group: SY
term-source: NCI

Primary Brain Neoplasm
type: Class
code: C4952
Semantic_Type: Neoplastic Process
Preferred_Name: Primary Brain Neoplasm
UMLS_CUI: C0750974
Neoplastic_Status: Undetermined
Legacy_Concept_Name: Primary_Brain_Neoplasm
has exact synonym: Primary Brain Neoplasm
has exact synonym: Primary Brain Tumor
in subset: oncotree slim

Axiom
annotated source: Primary Brain Neoplasm
annotated property: has exact synonym
annotated target: Primary Brain Neoplasm
term-group: PT
term-source: NCI

Axiom
annotated source: Primary Brain Neoplasm
annotated property: has exact synonym
annotated target: Primary Brain Tumor
term-group: SY
term-source: NCI

Desmoplastic/Nodular Medulloblastoma
type: Class
subclass of: Medulloblastoma
definition: A medulloblastoma characterized by the presence of nodular, collagenous areas which do not contain reticulin, surrounded by hypercellular areas which contain an intercellular reticulin fiber network.
Concept_In_Subset: NCIT C126659
code: C4956
Semantic_Type: Neoplastic Process
Preferred_Name: Desmoplastic/Nodular Medulloblastoma
UMLS_CUI: C0751291
ICD-O-3_Code: 9471/3
Neoplastic_Status: Malignant
Legacy_Concept_Name: Desmoplastic_Medulloblastoma
has exact synonym: Desmoplastic Medulloblastoma
has exact synonym: Desmoplastic Nodular Medulloblastoma
has exact synonym: Desmoplastic/Nodular Medulloblastoma
in subset: oncotree slim

Axiom
annotated source: Desmoplastic/Nodular Medulloblastoma
annotated property: definition
annotated target: A medulloblastoma characterized by the presence of nodular, collagenous areas which do not contain reticulin, surrounded by hypercellular areas which contain an intercellular reticulin fiber network.
def-source: NCI

Axiom
annotated source: Desmoplastic/Nodular Medulloblastoma
annotated property: has exact synonym
annotated target: Desmoplastic Medulloblastoma
term-group: SY
term-source: NCI

Axiom
annotated source: Desmoplastic/Nodular Medulloblastoma
annotated property: has exact synonym
annotated target: Desmoplastic Nodular Medulloblastoma
term-group: SY
term-source: NCI

Axiom
annotated source: Desmoplastic/Nodular Medulloblastoma
annotated property: has exact synonym
annotated target: Desmoplastic/Nodular Medulloblastoma
term-group: PT
term-source: NCI

Axiom
annotated source: Desmoplastic/Nodular Medulloblastoma
annotated property: has exact synonym
annotated target: Desmoplastic/Nodular Medulloblastoma
term-group: SY
term-source: NCI
source-code: TCGA
subsource-name: caDSR

Nerve Sheath Neoplasm
type: Class
definition: A benign or malignant neoplasm arising from the perineural cells in the sheaths surrounding the nerves. Representative examples include neurofibroma, schwannoma, and malignant peripheral nerve sheath tumor.
code: C4972
Semantic_Type: Neoplastic Process
Preferred_Name: Nerve Sheath Neoplasm
UMLS_CUI: C0206727
Neoplastic_Status: Undetermined
Legacy_Concept_Name: Peripheral_Nerve_Sheath_Neoplasm
has exact synonym: Neoplasm of Nerve Sheath
has exact synonym: Neoplasm of the Nerve Sheath
has exact synonym: Nerve Sheath Neoplasm
has exact synonym: Nerve Sheath Tumor
has exact synonym: Tumor of Nerve Sheath
in subset: oncotree slim

Axiom
annotated source: Nerve Sheath Neoplasm
annotated property: definition
annotated target: A benign or malignant neoplasm arising from the perineural cells in the sheaths surrounding the nerves. Representative examples include neurofibroma, schwannoma, and malignant peripheral nerve sheath tumor.
def-source: NCI

Axiom
annotated source: Nerve Sheath Neoplasm
annotated property: has exact synonym
annotated target: Neoplasm of Nerve Sheath
term-group: SY
term-source: NCI

Axiom
annotated source: Nerve Sheath Neoplasm
annotated property: has exact synonym
annotated target: Neoplasm of the Nerve Sheath
term-group: SY
term-source: NCI

Axiom
annotated source: Nerve Sheath Neoplasm
annotated property: has exact synonym
annotated target: Nerve Sheath Neoplasm
term-group: PT
term-source: NCI

Axiom
annotated source: Nerve Sheath Neoplasm
annotated property: has exact synonym
annotated target: Nerve Sheath Tumor
term-group: SY
term-source: NCI

Axiom
annotated source: Nerve Sheath Neoplasm
annotated property: has exact synonym
annotated target: Tumor of Nerve Sheath
term-group: SY
term-source: NCI

Myopericytoma
type: Class
definition: A usually slow growing, subcutaneous nodular neoplasm arising from myopericytes. It is composed of myoid cells arranged in a perivascular growth pattern. The vast majority of cases have a benign clinical course.
code: C50401
Semantic_Type: Neoplastic Process
Preferred_Name: Myopericytoma
UMLS_CUI: C1302808
ICD-O-3_Code: 8713/1
Neoplastic_Status: Undetermined
Legacy_Concept_Name: Myopericytoma
has exact synonym: Hemangiopericytoma
has exact synonym: Myopericytoma
has exact synonym: Solitary Myofibroma
in subset: oncotree slim

Axiom
annotated source: Myopericytoma
annotated property: definition
annotated target: A usually slow growing, subcutaneous nodular neoplasm arising from myopericytes. It is composed of myoid cells arranged in a perivascular growth pattern. The vast majority of cases have a benign clinical course.
def-source: NCI

Axiom
annotated source: Myopericytoma
annotated property: has exact synonym
annotated target: Hemangiopericytoma
term-group: AQS
term-source: NCI

Axiom
annotated source: Myopericytoma
annotated property: has exact synonym
annotated target: Myopericytoma
term-group: PT
term-source: NCI

Axiom
annotated source: Myopericytoma
annotated property: has exact synonym
annotated target: Solitary Myofibroma
term-group: AQS
term-source: NCI

Colorectal Adenocarcinoma
type: Class
definition: The most common type of colorectal carcinoma. It is characterized by the presence of malignant glandular epithelial cells invading through the muscularis mucosa into the submucosa. Histologic variants include mucinous adenocarcinoma, signet ring cell carcinoma, medullary carcinoma, serrated adenocarcinoma, cribriform comedo-type adenocarcinoma, and micropapillary adenocarcinoma.
Concept_In_Subset: NCIT C126659
code: C5105
Semantic_Type: Neoplastic Process
Preferred_Name: Colorectal Adenocarcinoma
UMLS_CUI: C1319315
Neoplastic_Status: Malignant
Legacy_Concept_Name: Colorectal_Adenocarcinoma
has exact synonym: Adenocarcinoma of Large Bowel
has exact synonym: Adenocarcinoma of Large Intestine
has exact synonym: Adenocarcinoma of the Large Bowel
has exact synonym: Adenocarcinoma of the Large Intestine
has exact synonym: Colorectal Adenocarcinoma
has exact synonym: Large Bowel Adenocarcinoma
has exact synonym: Large Intestine Adenocarcinoma
in subset: oncotree slim

Axiom
annotated source: Colorectal Adenocarcinoma
annotated property: definition
annotated target: The most common type of colorectal carcinoma. It is characterized by the presence of malignant glandular epithelial cells invading through the muscularis mucosa into the submucosa. Histologic variants include mucinous adenocarcinoma, signet ring cell carcinoma, medullary carcinoma, serrated adenocarcinoma, cribriform comedo-type adenocarcinoma, and micropapillary adenocarcinoma.
def-source: NCI

Axiom
annotated source: Colorectal Adenocarcinoma
annotated property: has exact synonym
annotated target: Adenocarcinoma of Large Bowel
term-group: SY
term-source: NCI

Axiom
annotated source: Colorectal Adenocarcinoma
annotated property: has exact synonym
annotated target: Adenocarcinoma of Large Intestine
term-group: SY
term-source: NCI

Axiom
annotated source: Colorectal Adenocarcinoma
annotated property: has exact synonym
annotated target: Adenocarcinoma of the Large Bowel
term-group: SY
term-source: NCI

Axiom
annotated source: Colorectal Adenocarcinoma
annotated property: has exact synonym
annotated target: Adenocarcinoma of the Large Intestine
term-group: SY
term-source: NCI

Axiom
annotated source: Colorectal Adenocarcinoma
annotated property: has exact synonym
annotated target: Colorectal Adenocarcinoma
term-group: DN
term-source: CTRP

Axiom
annotated source: Colorectal Adenocarcinoma
annotated property: has exact synonym
annotated target: Colorectal Adenocarcinoma
term-group: PT
term-source: NCI

Axiom
annotated source: Colorectal Adenocarcinoma
annotated property: has exact synonym
annotated target: Large Bowel Adenocarcinoma
term-group: SY
term-source: NCI

Axiom
annotated source: Colorectal Adenocarcinoma
annotated property: has exact synonym
annotated target: Large Intestine Adenocarcinoma
term-group: SY
term-source: NCI

Adenoid Cystic Breast Carcinoma
type: Class
equivalent class: Class
  intersection of: Adenoid Cystic Carcinoma
  intersection of: NCIT C9245
subclass of: Adenoid Cystic Carcinoma
subclass of: NCIT C9245
definition: An adenoid cystic carcinoma primarily involving the breast. Three morphologic patterns are seen: cribriform, trabecular, and solid. The prognosis is excellent.
Concept_In_Subset: NCIT C126659
code: C5130
Semantic_Type: Neoplastic Process
Preferred_Name: Adenoid Cystic Breast Carcinoma
UMLS_CUI: C1332167
Neoplastic_Status: Malignant
Legacy_Concept_Name: Adenoid_Cystic_Breast_Carcinoma
has exact synonym: Adenocystic Breast Carcinoma
has exact synonym: Adenocystic Carcinoma of Breast
has exact synonym: Adenocystic Carcinoma of the Breast
has exact synonym: Adenoid Cystic Breast Carcinoma
has exact synonym: Adenoid Cystic Carcinoma of Breast
has exact synonym: Adenoid Cystic Carcinoma of the Breast
has exact synonym: Mammary Adenocystic Carcinoma
in subset: oncotree slim

Axiom
annotated source: Adenoid Cystic Breast Carcinoma
annotated property: definition
annotated target: An adenoid cystic carcinoma primarily involving the breast. Three morphologic patterns are seen: cribriform, trabecular, and solid. The prognosis is excellent.
def-source: NCI

Axiom
annotated source: Adenoid Cystic Breast Carcinoma
annotated property: has exact synonym
annotated target: Adenocystic Breast Carcinoma
term-group: SY
term-source: NCI

Axiom
annotated source: Adenoid Cystic Breast Carcinoma
annotated property: has exact synonym
annotated target: Adenocystic Carcinoma of Breast
term-group: SY
term-source: NCI

Axiom
annotated source: Adenoid Cystic Breast Carcinoma
annotated property: has exact synonym
annotated target: Adenocystic Carcinoma of the Breast
term-group: SY
term-source: NCI

Axiom
annotated source: Adenoid Cystic Breast Carcinoma
annotated property: has exact synonym
annotated target: Adenoid Cystic Breast Carcinoma
term-group: PT
term-source: NCI

Axiom
annotated source: Adenoid Cystic Breast Carcinoma
annotated property: has exact synonym
annotated target: Adenoid Cystic Carcinoma of Breast
term-group: SY
term-source: NCI

Axiom
annotated source: Adenoid Cystic Breast Carcinoma
annotated property: has exact synonym
annotated target: Adenoid Cystic Carcinoma of the Breast
term-group: SY
term-source: NCI

Axiom
annotated source: Adenoid Cystic Breast Carcinoma
annotated property: has exact synonym
annotated target: Mammary Adenocystic Carcinoma
term-group: SY
term-source: NCI

Mixed Lobular and Ductal Breast Carcinoma
type: Class
definition: A breast carcinoma characterized by the presence of a lobular and a ductal component. The ductal component comprises less than 50 percent of the tumor.
Concept_In_Subset: NCIT C126659
code: C5160
Semantic_Type: Neoplastic Process
Preferred_Name: Mixed Lobular and Ductal Breast Carcinoma
NCI_META_CUI: CL007210
Neoplastic_Status: Malignant
Legacy_Concept_Name: Mixed_Lobular_and_Ductal_Breast_Carcinoma
has exact synonym: Ductal and Lobular Carcinoma
has exact synonym: Mixed Ductal and Lobular Breast Carcinoma
has exact synonym: Mixed Ductal and Lobular Carcinoma of Breast
has exact synonym: Mixed Ductal and Lobular Carcinoma of the Breast
has exact synonym: Mixed Lobular and Ductal Breast Carcinoma
has exact synonym: Mixed Lobular and Ductal Carcinoma
has exact synonym: Mixed Lobular and Ductal Carcinoma of Breast
has exact synonym: Mixed Lobular and Ductal Carcinoma of the Breast
in subset: oncotree slim

Axiom
annotated source: Mixed Lobular and Ductal Breast Carcinoma
annotated property: definition
annotated target: A breast carcinoma characterized by the presence of a lobular and a ductal component. The ductal component comprises less than 50 percent of the tumor.
def-source: NCI

Axiom
annotated source: Mixed Lobular and Ductal Breast Carcinoma
annotated property: has exact synonym
annotated target: Ductal and Lobular Carcinoma
term-group: SY
term-source: NCI

Axiom
annotated source: Mixed Lobular and Ductal Breast Carcinoma
annotated property: has exact synonym
annotated target: Mixed Ductal and Lobular Breast Carcinoma
term-group: SY
term-source: NCI

Axiom
annotated source: Mixed Lobular and Ductal Breast Carcinoma
annotated property: has exact synonym
annotated target: Mixed Ductal and Lobular Carcinoma of Breast
term-group: SY
term-source: NCI

Axiom
annotated source: Mixed Lobular and Ductal Breast Carcinoma
annotated property: has exact synonym
annotated target: Mixed Ductal and Lobular Carcinoma of the Breast
term-group: SY
term-source: NCI

Axiom
annotated source: Mixed Lobular and Ductal Breast Carcinoma
annotated property: has exact synonym
annotated target: Mixed Lobular and Ductal Breast Carcinoma
term-group: PT
term-source: NCI

Axiom
annotated source: Mixed Lobular and Ductal Breast Carcinoma
annotated property: has exact synonym
annotated target: Mixed Lobular and Ductal Carcinoma
term-group: SY
term-source: NCI

Axiom
annotated source: Mixed Lobular and Ductal Breast Carcinoma
annotated property: has exact synonym
annotated target: Mixed Lobular and Ductal Carcinoma of Breast
term-group: SY
term-source: NCI

Axiom
annotated source: Mixed Lobular and Ductal Breast Carcinoma
annotated property: has exact synonym
annotated target: Mixed Lobular and Ductal Carcinoma of the Breast
term-group: SY
term-source: NCI

Metaplastic Breast Carcinoma
type: Class
subclass of: NCIT C9245
definition: A group of invasive breast carcinomas characterized by the presence of an adenocarcinomatous component which is admixed with a dominant component that is composed of squamous cells, spindle cells, or mesenchymal cells.
code: C5164
Semantic_Type: Neoplastic Process
Preferred_Name: Metaplastic Breast Carcinoma
UMLS_CUI: C1334708
Neoplastic_Status: Malignant
Legacy_Concept_Name: Metaplastic_Breast_Carcinoma
has exact synonym: Metaplastic Breast Carcinoma
has exact synonym: Metaplastic Carcinoma of Breast
has exact synonym: Metaplastic Carcinoma of the Breast
in subset: oncotree slim

Axiom
annotated source: Metaplastic Breast Carcinoma
annotated property: definition
annotated target: A group of invasive breast carcinomas characterized by the presence of an adenocarcinomatous component which is admixed with a dominant component that is composed of squamous cells, spindle cells, or mesenchymal cells.
def-source: NCI

Axiom
annotated source: Metaplastic Breast Carcinoma
annotated property: has exact synonym
annotated target: Metaplastic Breast Carcinoma
term-group: PT
term-source: NCI

Axiom
annotated source: Metaplastic Breast Carcinoma
annotated property: has exact synonym
annotated target: Metaplastic Carcinoma of Breast
term-group: SY
term-source: NCI

Axiom
annotated source: Metaplastic Breast Carcinoma
annotated property: has exact synonym
annotated target: Metaplastic Carcinoma of the Breast
term-group: SY
term-source: NCI

Signet Ring Cell Breast Carcinoma
type: Class
subclass of: NCIT C9245
definition: An invasive breast adenocarcinoma characterized by the presence of malignant epithelial cells with signet ring appearance.
code: C5175
Semantic_Type: Neoplastic Process
Preferred_Name: Signet Ring Cell Breast Carcinoma
UMLS_CUI: C1335964
Neoplastic_Status: Malignant
Legacy_Concept_Name: Signet_Ring_Cell_Breast_Carcinoma
has exact synonym: Mammary Signet Ring Cell Carcinoma
has exact synonym: Primary Mammary Signet Ring Cell Carcinoma
has exact synonym: Primary SRC Breast Carcinoma
has exact synonym: Primary SRC Carcinoma of Breast
has exact synonym: Primary SRC Carcinoma of the Breast
has exact synonym: Primary Signet Ring Cell Breast Carcinoma
has exact synonym: Primary Signet Ring Cell Carcinoma of Breast
has exact synonym: Primary Signet Ring Cell Carcinoma of the Breast
has exact synonym: SRC Breast Carcinoma
has exact synonym: SRC Carcinoma of Breast
has exact synonym: SRC Carcinoma of the Breast
has exact synonym: Signet Ring Cell Breast Carcinoma
has exact synonym: Signet Ring Cell Carcinoma of Breast
has exact synonym: Signet Ring Cell Carcinoma of the Breast
in subset: oncotree slim

Axiom
annotated source: Signet Ring Cell Breast Carcinoma
annotated property: definition
annotated target: An invasive breast adenocarcinoma characterized by the presence of malignant epithelial cells with signet ring appearance.
def-source: NCI

Axiom
annotated source: Signet Ring Cell Breast Carcinoma
annotated property: has exact synonym
annotated target: Mammary Signet Ring Cell Carcinoma
term-group: SY
term-source: NCI

Axiom
annotated source: Signet Ring Cell Breast Carcinoma
annotated property: has exact synonym
annotated target: Primary Mammary Signet Ring Cell Carcinoma
term-group: SY
term-source: NCI

Axiom
annotated source: Signet Ring Cell Breast Carcinoma
annotated property: has exact synonym
annotated target: Primary SRC Breast Carcinoma
term-group: SY
term-source: NCI

Axiom
annotated source: Signet Ring Cell Breast Carcinoma
annotated property: has exact synonym
annotated target: Primary SRC Carcinoma of Breast
term-group: SY
term-source: NCI

Axiom
annotated source: Signet Ring Cell Breast Carcinoma
annotated property: has exact synonym
annotated target: Primary SRC Carcinoma of the Breast
term-group: SY
term-source: NCI

Axiom
annotated source: Signet Ring Cell Breast Carcinoma
annotated property: has exact synonym
annotated target: Primary Signet Ring Cell Breast Carcinoma
term-group: SY
term-source: NCI

Axiom
annotated source: Signet Ring Cell Breast Carcinoma
annotated property: has exact synonym
annotated target: Primary Signet Ring Cell Carcinoma of Breast
term-group: SY
term-source: NCI

Axiom
annotated source: Signet Ring Cell Breast Carcinoma
annotated property: has exact synonym
annotated target: Primary Signet Ring Cell Carcinoma of the Breast
term-group: SY
term-source: NCI

Axiom
annotated source: Signet Ring Cell Breast Carcinoma
annotated property: has exact synonym
annotated target: SRC Breast Carcinoma
term-group: SY
term-source: NCI

Axiom
annotated source: Signet Ring Cell Breast Carcinoma
annotated property: has exact synonym
annotated target: SRC Carcinoma of Breast
term-group: SY
term-source: NCI

Axiom
annotated source: Signet Ring Cell Breast Carcinoma
annotated property: has exact synonym
annotated target: SRC Carcinoma of the Breast
term-group: SY
term-source: NCI

Axiom
annotated source: Signet Ring Cell Breast Carcinoma
annotated property: has exact synonym
annotated target: Signet Ring Cell Breast Carcinoma
term-group: PT
term-source: NCI

Axiom
annotated source: Signet Ring Cell Breast Carcinoma
annotated property: has exact synonym
annotated target: Signet Ring Cell Carcinoma of Breast
term-group: SY
term-source: NCI

Axiom
annotated source: Signet Ring Cell Breast Carcinoma
annotated property: has exact synonym
annotated target: Signet Ring Cell Carcinoma of the Breast
term-group: SY
term-source: NCI

Squamous Cell Breast Carcinoma
type: Class
subclass of: NCIT C9245
definition: A rare carcinoma that arises from the breast parenchyma and is entirely composed of squamous cells.
Concept_In_Subset: NCIT C126659
code: C5177
Semantic_Type: Neoplastic Process
Preferred_Name: Squamous Cell Breast Carcinoma
UMLS_CUI: C1336079
Neoplastic_Status: Malignant
Legacy_Concept_Name: Squamous_Cell_Breast_Carcinoma
has exact synonym: Primary Squamous Cell Breast Carcinoma
has exact synonym: Primary Squamous Cell Carcinoma of Breast
has exact synonym: Primary Squamous Cell Carcinoma of the Breast
has exact synonym: SCC of Breast
has exact synonym: SCC of the Breast
has exact synonym: Squamous Breast Carcinoma
has exact synonym: Squamous Carcinoma of Breast
has exact synonym: Squamous Carcinoma of the Breast
has exact synonym: Squamous Cell Breast Carcinoma
has exact synonym: Squamous Cell Carcinoma of Breast
has exact synonym: Squamous Cell Carcinoma of the Breast
in subset: oncotree slim

Axiom
annotated source: Squamous Cell Breast Carcinoma
annotated property: definition
annotated target: A rare carcinoma that arises from the breast parenchyma and is entirely composed of squamous cells.
def-source: NCI

Axiom
annotated source: Squamous Cell Breast Carcinoma
annotated property: has exact synonym
annotated target: Primary Squamous Cell Breast Carcinoma
term-group: SY
term-source: NCI

Axiom
annotated source: Squamous Cell Breast Carcinoma
annotated property: has exact synonym
annotated target: Primary Squamous Cell Carcinoma of Breast
term-group: SY
term-source: NCI

Axiom
annotated source: Squamous Cell Breast Carcinoma
annotated property: has exact synonym
annotated target: Primary Squamous Cell Carcinoma of the Breast
term-group: SY
term-source: NCI

Axiom
annotated source: Squamous Cell Breast Carcinoma
annotated property: has exact synonym
annotated target: SCC of Breast
term-group: SY
term-source: NCI

Axiom
annotated source: Squamous Cell Breast Carcinoma
annotated property: has exact synonym
annotated target: SCC of the Breast
term-group: SY
term-source: NCI

Axiom
annotated source: Squamous Cell Breast Carcinoma
annotated property: has exact synonym
annotated target: Squamous Breast Carcinoma
term-group: SY
term-source: NCI

Axiom
annotated source: Squamous Cell Breast Carcinoma
annotated property: has exact synonym
annotated target: Squamous Carcinoma of Breast
term-group: SY
term-source: NCI

Axiom
annotated source: Squamous Cell Breast Carcinoma
annotated property: has exact synonym
annotated target: Squamous Carcinoma of the Breast
term-group: SY
term-source: NCI

Axiom
annotated source: Squamous Cell Breast Carcinoma
annotated property: has exact synonym
annotated target: Squamous Cell Breast Carcinoma
term-group: PT
term-source: NCI

Axiom
annotated source: Squamous Cell Breast Carcinoma
annotated property: has exact synonym
annotated target: Squamous Cell Carcinoma of Breast
term-group: SY
term-source: NCI

Axiom
annotated source: Squamous Cell Breast Carcinoma
annotated property: has exact synonym
annotated target: Squamous Cell Carcinoma of the Breast
term-group: SY
term-source: NCI

Benign Breast Phyllodes Tumor
type: Class
subclass of: Breast Phyllodes Tumor
definition: A usually unilateral, benign and well circumscribed biphasic neoplasm that arises from the breast. It usually affects middle-aged women. It is characterized by the presence of a double layer of epithelial cells that are arranged in clefts, surrounded by a cellular, monomorphic spindle cell mesenchymal component. Mitoses are rare. Necrotic changes may be present in large tumors.
Concept_In_Subset: NCIT C126659
code: C5196
Semantic_Type: Neoplastic Process
Preferred_Name: Benign Breast Phyllodes Tumor
UMLS_CUI: C1332533
Neoplastic_Status: Benign
Legacy_Concept_Name: Benign_Phyllodes_Tumor_of_the_Breast
has exact synonym: Benign Breast Phyllodes Tumor
has exact synonym: Benign Phyllodes Neoplasm of Breast
has exact synonym: Benign Phyllodes Neoplasm of the Breast
has exact synonym: Benign Phyllodes Tumor of Breast
has exact synonym: Benign Phyllodes Tumor of the Breast
has exact synonym: Breast Benign Phyllodes Neoplasm
in subset: oncotree slim

Axiom
annotated source: Benign Breast Phyllodes Tumor
annotated property: definition
annotated target: A usually unilateral, benign and well circumscribed biphasic neoplasm that arises from the breast. It usually affects middle-aged women. It is characterized by the presence of a double layer of epithelial cells that are arranged in clefts, surrounded by a cellular, monomorphic spindle cell mesenchymal component. Mitoses are rare. Necrotic changes may be present in large tumors.
def-source: NCI

Axiom
annotated source: Benign Breast Phyllodes Tumor
annotated property: has exact synonym
annotated target: Benign Breast Phyllodes Tumor
term-group: PT
term-source: NCI

Axiom
annotated source: Benign Breast Phyllodes Tumor
annotated property: has exact synonym
annotated target: Benign Phyllodes Neoplasm of Breast
term-group: SY
term-source: NCI

Axiom
annotated source: Benign Breast Phyllodes Tumor
annotated property: has exact synonym
annotated target: Benign Phyllodes Neoplasm of the Breast
term-group: SY
term-source: NCI

Axiom
annotated source: Benign Breast Phyllodes Tumor
annotated property: has exact synonym
annotated target: Benign Phyllodes Tumor of Breast
term-group: SY
term-source: NCI

Axiom
annotated source: Benign Breast Phyllodes Tumor
annotated property: has exact synonym
annotated target: Benign Phyllodes Tumor of the Breast
term-group: SY
term-source: NCI

Axiom
annotated source: Benign Breast Phyllodes Tumor
annotated property: has exact synonym
annotated target: Breast Benign Phyllodes Neoplasm
term-group: SY
term-source: NCI

Borderline Ovarian Serous Tumor
type: Class
definition: A low grade serous epithelial neoplasm arising from the ovary. It is characterized by an atypical proliferation of serous-type epithelial cells without evidence of stromal invasion. It is often asymptomatic but rarely it may present with abdominal pain or abdominal enlargement due to rupture or torsion.
Concept_In_Subset: NCIT C116977
code: C5226
Semantic_Type: Neoplastic Process
Display_Name: Borderline Ovarian Serous Tumor
Preferred_Name: Borderline Ovarian Serous Tumor
UMLS_CUI: C1332598
Contributing_Source: CTRP
Neoplastic_Status: Undetermined
Legacy_Concept_Name: Borderline_Ovarian_Serous_Neoplasm
has exact synonym: Borderline Ovarian Serous Neoplasm
has exact synonym: Borderline Ovarian Serous Tumor
has exact synonym: Borderline Serous Neoplasm of Ovary
has exact synonym: Borderline Serous Neoplasm of the Ovary
has exact synonym: Borderline Serous Tumor of Ovary
has exact synonym: Borderline Serous Tumor of the Ovary
has exact synonym: Ovarian Serous Neoplasm of Low Malignant Potential
has exact synonym: Ovarian Serous Tumor of Low Malignant Potential
has exact synonym: Proliferating Ovarian Serous Neoplasm
has exact synonym: Proliferating Ovarian Serous Tumor
has exact synonym: Proliferating Serous Neoplasm of Ovary
has exact synonym: Proliferating Serous Neoplasm of the Ovary
has exact synonym: Proliferating Serous Tumor of Ovary
has exact synonym: Proliferating Serous Tumor of the Ovary
has exact synonym: Serous Neoplasm of Ovary with Low Malignant Potential
has exact synonym: Serous Neoplasm of the Ovary with Low Malignant Potential
has exact synonym: Serous Ovarian Neoplasm of Low Malignant Potential
has exact synonym: Serous Ovarian Tumor of Low Malignant Potential
has exact synonym: Serous Tumor of Ovary with Low Malignant Potential
has exact synonym: Serous Tumor of the Ovary with Low Malignant Potential
in subset: oncotree slim

Axiom
annotated source: Borderline Ovarian Serous Tumor
annotated property: definition
annotated target: A low grade serous epithelial neoplasm arising from the ovary. It is characterized by an atypical proliferation of serous-type epithelial cells without evidence of stromal invasion. It is often asymptomatic but rarely it may present with abdominal pain or abdominal enlargement due to rupture or torsion.
def-source: NCI

Axiom
annotated source: Borderline Ovarian Serous Tumor
annotated property: has exact synonym
annotated target: Borderline Ovarian Serous Neoplasm
term-group: SY
term-source: NCI

Axiom
annotated source: Borderline Ovarian Serous Tumor
annotated property: has exact synonym
annotated target: Borderline Ovarian Serous Tumor
term-group: PT
term-source: NCI

Axiom
annotated source: Borderline Ovarian Serous Tumor
annotated property: has exact synonym
annotated target: Borderline Serous Neoplasm of Ovary
term-group: SY
term-source: NCI

Axiom
annotated source: Borderline Ovarian Serous Tumor
annotated property: has exact synonym
annotated target: Borderline Serous Neoplasm of the Ovary
term-group: SY
term-source: NCI

Axiom
annotated source: Borderline Ovarian Serous Tumor
annotated property: has exact synonym
annotated target: Borderline Serous Tumor of Ovary
term-group: SY
term-source: NCI

Axiom
annotated source: Borderline Ovarian Serous Tumor
annotated property: has exact synonym
annotated target: Borderline Serous Tumor of the Ovary
term-group: SY
term-source: NCI

Axiom
annotated source: Borderline Ovarian Serous Tumor
annotated property: has exact synonym
annotated target: Ovarian Serous Neoplasm of Low Malignant Potential
term-group: SY
term-source: NCI

Axiom
annotated source: Borderline Ovarian Serous Tumor
annotated property: has exact synonym
annotated target: Ovarian Serous Tumor of Low Malignant Potential
term-group: SY
term-source: NCI

Axiom
annotated source: Borderline Ovarian Serous Tumor
annotated property: has exact synonym
annotated target: Proliferating Ovarian Serous Neoplasm
term-group: SY
term-source: NCI

Axiom
annotated source: Borderline Ovarian Serous Tumor
annotated property: has exact synonym
annotated target: Proliferating Ovarian Serous Tumor
term-group: SY
term-source: NCI

Axiom
annotated source: Borderline Ovarian Serous Tumor
annotated property: has exact synonym
annotated target: Proliferating Serous Neoplasm of Ovary
term-group: SY
term-source: NCI

Axiom
annotated source: Borderline Ovarian Serous Tumor
annotated property: has exact synonym
annotated target: Proliferating Serous Neoplasm of the Ovary
term-group: SY
term-source: NCI

Axiom
annotated source: Borderline Ovarian Serous Tumor
annotated property: has exact synonym
annotated target: Proliferating Serous Tumor of Ovary
term-group: SY
term-source: NCI

Axiom
annotated source: Borderline Ovarian Serous Tumor
annotated property: has exact synonym
annotated target: Proliferating Serous Tumor of the Ovary
term-group: SY
term-source: NCI

Axiom
annotated source: Borderline Ovarian Serous Tumor
annotated property: has exact synonym
annotated target: Serous Neoplasm of Ovary with Low Malignant Potential
term-group: SY
term-source: NCI

Axiom
annotated source: Borderline Ovarian Serous Tumor
annotated property: has exact synonym
annotated target: Serous Neoplasm of the Ovary with Low Malignant Potential
term-group: SY
term-source: NCI

Axiom
annotated source: Borderline Ovarian Serous Tumor
annotated property: has exact synonym
annotated target: Serous Ovarian Neoplasm of Low Malignant Potential
term-group: SY
term-source: NCI

Axiom
annotated source: Borderline Ovarian Serous Tumor
annotated property: has exact synonym
annotated target: Serous Ovarian Tumor of Low Malignant Potential
term-group: SY
term-source: NCI

Axiom
annotated source: Borderline Ovarian Serous Tumor
annotated property: has exact synonym
annotated target: Serous Tumor of Ovary with Low Malignant Potential
term-group: SY
term-source: NCI

Axiom
annotated source: Borderline Ovarian Serous Tumor
annotated property: has exact synonym
annotated target: Serous Tumor of the Ovary with Low Malignant Potential
term-group: SY
term-source: NCI

Ovarian Mucinous Tumor
type: Class
subclass of: Ovarian Epithelial Tumor
definition: A benign, borderline, or malignant epithelial tumor of the ovary characterized by the presence of neoplastic epithelial cells that contain intracytoplasmic mucin and may resemble the epithelial cells of the endocervix or gastrointestinal tract.
code: C5242
Semantic_Type: Neoplastic Process
Preferred_Name: Ovarian Mucinous Tumor
UMLS_CUI: C1335168
Neoplastic_Status: Undetermined
Legacy_Concept_Name: Ovarian_Mucinous_Neoplasm
has exact synonym: Mucinous Neoplasm of Ovary
has exact synonym: Mucinous Neoplasm of the Ovary
has exact synonym: Mucinous Tumor of Ovary
has exact synonym: Mucinous Tumor of the Ovary
has exact synonym: Ovarian Mucinous Neoplasm
has exact synonym: Ovarian Mucinous Tumor
in subset: oncotree slim

Axiom
annotated source: Ovarian Mucinous Tumor
annotated property: definition
annotated target: A benign, borderline, or malignant epithelial tumor of the ovary characterized by the presence of neoplastic epithelial cells that contain intracytoplasmic mucin and may resemble the epithelial cells of the endocervix or gastrointestinal tract.
def-source: NCI

Axiom
annotated source: Ovarian Mucinous Tumor
annotated property: has exact synonym
annotated target: Mucinous Neoplasm of Ovary
term-group: SY
term-source: NCI

Axiom
annotated source: Ovarian Mucinous Tumor
annotated property: has exact synonym
annotated target: Mucinous Neoplasm of the Ovary
term-group: SY
term-source: NCI

Axiom
annotated source: Ovarian Mucinous Tumor
annotated property: has exact synonym
annotated target: Mucinous Tumor of Ovary
term-group: SY
term-source: NCI

Axiom
annotated source: Ovarian Mucinous Tumor
annotated property: has exact synonym
annotated target: Mucinous Tumor of the Ovary
term-group: SY
term-source: NCI

Axiom
annotated source: Ovarian Mucinous Tumor
annotated property: has exact synonym
annotated target: Ovarian Mucinous Neoplasm
term-group: SY
term-source: NCI

Axiom
annotated source: Ovarian Mucinous Tumor
annotated property: has exact synonym
annotated target: Ovarian Mucinous Tumor
term-group: PT
term-source: NCI

Mucinous Gastric Adenocarcinoma
type: Class
subclass of: Mucinous Adenocarcinoma
definition: A variant of gastric adenocarcinoma with more than half of the tumor containing extracellular mucinous pools.
Concept_In_Subset: NCIT C126659
code: C5248
Semantic_Type: Neoplastic Process
Preferred_Name: Mucinous Gastric Adenocarcinoma
UMLS_CUI: C1334809
Neoplastic_Status: Malignant
Legacy_Concept_Name: Mucinous_Gastric_Adenocarcinoma
has exact synonym: Mucinous Adenocarcinoma of Stomach
has exact synonym: Mucinous Adenocarcinoma of the Stomach
has exact synonym: Mucinous Gastric Adenocarcinoma
has exact synonym: Mucinous Stomach Adenocarcinoma
in subset: oncotree slim

Axiom
annotated source: Mucinous Gastric Adenocarcinoma
annotated property: definition
annotated target: A variant of gastric adenocarcinoma with more than half of the tumor containing extracellular mucinous pools.
def-source: NCI

Axiom
annotated source: Mucinous Gastric Adenocarcinoma
annotated property: has exact synonym
annotated target: Mucinous Adenocarcinoma of Stomach
term-group: SY
term-source: NCI

Axiom
annotated source: Mucinous Gastric Adenocarcinoma
annotated property: has exact synonym
annotated target: Mucinous Adenocarcinoma of the Stomach
term-group: SY
term-source: NCI

Axiom
annotated source: Mucinous Gastric Adenocarcinoma
annotated property: has exact synonym
annotated target: Mucinous Gastric Adenocarcinoma
term-group: PT
term-source: NCI

Axiom
annotated source: Mucinous Gastric Adenocarcinoma
annotated property: has exact synonym
annotated target: Mucinous Gastric Adenocarcinoma
term-group: SY
term-source: NCI
source-code: TCGA
subsource-name: caDSR

Axiom
annotated source: Mucinous Gastric Adenocarcinoma
annotated property: has exact synonym
annotated target: Mucinous Stomach Adenocarcinoma
term-group: SY
term-source: NCI

Signet Ring Cell Gastric Adenocarcinoma
type: Class
definition: A poorly cohesive gastric adenocarcinoma characterized by malignant cells containing intracytoplasmic mucin.
Concept_In_Subset: NCIT C126659
code: C5250
Semantic_Type: Neoplastic Process
Preferred_Name: Signet Ring Cell Gastric Adenocarcinoma
UMLS_CUI: C1335965
Neoplastic_Status: Malignant
Legacy_Concept_Name: Signet_Ring_Cell_Gastric_Adenocarcinoma
has exact synonym: Gastric Signet Ring Cell Adenocarcinoma
has exact synonym: Signet Ring Cell Adenocarcinoma of Stomach
has exact synonym: Signet Ring Cell Adenocarcinoma of the Stomach
has exact synonym: Signet Ring Cell Gastric Adenocarcinoma
has exact synonym: Signet Ring Cell Stomach Adenocarcinoma
in subset: oncotree slim

Axiom
annotated source: Signet Ring Cell Gastric Adenocarcinoma
annotated property: definition
annotated target: A poorly cohesive gastric adenocarcinoma characterized by malignant cells containing intracytoplasmic mucin.
def-source: NCI

Axiom
annotated source: Signet Ring Cell Gastric Adenocarcinoma
annotated property: has exact synonym
annotated target: Gastric Signet Ring Cell Adenocarcinoma
term-group: SY
term-source: NCI

Axiom
annotated source: Signet Ring Cell Gastric Adenocarcinoma
annotated property: has exact synonym
annotated target: Signet Ring Cell Adenocarcinoma of Stomach
term-group: SY
term-source: NCI

Axiom
annotated source: Signet Ring Cell Gastric Adenocarcinoma
annotated property: has exact synonym
annotated target: Signet Ring Cell Adenocarcinoma of the Stomach
term-group: SY
term-source: NCI

Axiom
annotated source: Signet Ring Cell Gastric Adenocarcinoma
annotated property: has exact synonym
annotated target: Signet Ring Cell Gastric Adenocarcinoma
term-group: PT
term-source: NCI

Axiom
annotated source: Signet Ring Cell Gastric Adenocarcinoma
annotated property: has exact synonym
annotated target: Signet Ring Cell Stomach Adenocarcinoma
term-group: SY
term-source: NCI

Borderline Breast Phyllodes Tumor
type: Class
subclass of: Breast Phyllodes Tumor
definition: A phyllodes tumor of the breast characterized by the presence of intermediate features and a stroma which usually resembles low grade fibrosarcoma.
Concept_In_Subset: NCIT C126659
code: C5316
Semantic_Type: Neoplastic Process
Preferred_Name: Borderline Breast Phyllodes Tumor
UMLS_CUI: C1332592
Neoplastic_Status: Undetermined
Legacy_Concept_Name: Borderline_Breast_Phyllodes_Tumor
has exact synonym: Borderline Breast Phyllodes Neoplasm
has exact synonym: Borderline Breast Phyllodes Tumor
has exact synonym: Borderline Phyllodes Neoplasm of Breast
has exact synonym: Borderline Phyllodes Neoplasm of the Breast
has exact synonym: Borderline Phyllodes Tumor of Breast
has exact synonym: Borderline Phyllodes Tumor of the Breast
has exact synonym: Low Grade Malignant Breast Phyllodes Tumor
in subset: oncotree slim

Axiom
annotated source: Borderline Breast Phyllodes Tumor
annotated property: definition
annotated target: A phyllodes tumor of the breast characterized by the presence of intermediate features and a stroma which usually resembles low grade fibrosarcoma.
def-source: NCI

Axiom
annotated source: Borderline Breast Phyllodes Tumor
annotated property: has exact synonym
annotated target: Borderline Breast Phyllodes Neoplasm
term-group: SY
term-source: NCI

Axiom
annotated source: Borderline Breast Phyllodes Tumor
annotated property: has exact synonym
annotated target: Borderline Breast Phyllodes Tumor
term-group: PT
term-source: NCI

Axiom
annotated source: Borderline Breast Phyllodes Tumor
annotated property: has exact synonym
annotated target: Borderline Phyllodes Neoplasm of Breast
term-group: SY
term-source: NCI

Axiom
annotated source: Borderline Breast Phyllodes Tumor
annotated property: has exact synonym
annotated target: Borderline Phyllodes Neoplasm of the Breast
term-group: SY
term-source: NCI

Axiom
annotated source: Borderline Breast Phyllodes Tumor
annotated property: has exact synonym
annotated target: Borderline Phyllodes Tumor of Breast
term-group: SY
term-source: NCI

Axiom
annotated source: Borderline Breast Phyllodes Tumor
annotated property: has exact synonym
annotated target: Borderline Phyllodes Tumor of the Breast
term-group: SY
term-source: NCI

Axiom
annotated source: Borderline Breast Phyllodes Tumor
annotated property: has exact synonym
annotated target: Low Grade Malignant Breast Phyllodes Tumor
term-group: SY
term-source: NCI

Intimal Sarcoma
type: Class
definition: A malignant neoplasm arising from the large blood vessels. It is characterized by the presence of tumor cells that grow within the lumen of the blood vessels. The intraluminal tumor growth may result in vascular obstruction and spread of tumor emboli to peripheral organs. The prognosis is usually poor.
code: C53677
Semantic_Type: Neoplastic Process
Preferred_Name: Intimal Sarcoma
UMLS_CUI: C1708550
Neoplastic_Status: Malignant
Legacy_Concept_Name: Intimal_Sarcoma
has exact synonym: Intimal Sarcoma
in subset: oncotree slim

Axiom
annotated source: Intimal Sarcoma
annotated property: definition
annotated target: A malignant neoplasm arising from the large blood vessels. It is characterized by the presence of tumor cells that grow within the lumen of the blood vessels. The intraluminal tumor growth may result in vascular obstruction and spread of tumor emboli to peripheral organs. The prognosis is usually poor.
def-source: NCI

Axiom
annotated source: Intimal Sarcoma
annotated property: has exact synonym
annotated target: Intimal Sarcoma
term-group: PT
term-source: NCI

Atypical Choroid Plexus Papilloma
type: Class
subclass of: Choroid Plexus Neoplasm
definition: A choroid plexus papilloma characterized by increased mitotic activity.
code: C53686
Semantic_Type: Neoplastic Process
Preferred_Name: Atypical Choroid Plexus Papilloma
UMLS_CUI: C1266176
ICD-O-3_Code: 9390/1
Neoplastic_Status: Undetermined
Legacy_Concept_Name: Atypical_Choroid_Plexus_Papilloma
has exact synonym: Atypical Choroid Plexus Papilloma
in subset: oncotree slim

Axiom
annotated source: Atypical Choroid Plexus Papilloma
annotated property: definition
annotated target: A choroid plexus papilloma characterized by increased mitotic activity.
def-source: NCI

Axiom
annotated source: Atypical Choroid Plexus Papilloma
annotated property: has exact synonym
annotated target: Atypical Choroid Plexus Papilloma
term-group: PT
term-source: NCI

Secondary Osteosarcoma
type: Class
definition: An osteosarcoma arising from a pre-existing lesion of the bone, usually Paget disease, or due to radiation therapy.
Concept_In_Subset: NCIT C126659
code: C53704
Semantic_Type: Neoplastic Process
Preferred_Name: Secondary Osteosarcoma
UMLS_CUI: C1710042
Neoplastic_Status: Malignant
Legacy_Concept_Name: Secondary_Osteosarcoma
has exact synonym: Secondary Bone Osteosarcoma
has exact synonym: Secondary Osteosarcoma
in subset: oncotree slim

Axiom
annotated source: Secondary Osteosarcoma
annotated property: definition
annotated target: An osteosarcoma arising from a pre-existing lesion of the bone, usually Paget disease, or due to radiation therapy.
def-source: NCI

Axiom
annotated source: Secondary Osteosarcoma
annotated property: has exact synonym
annotated target: Secondary Bone Osteosarcoma
term-group: SY
term-source: NCI

Axiom
annotated source: Secondary Osteosarcoma
annotated property: has exact synonym
annotated target: Secondary Osteosarcoma
term-group: PT
term-source: NCI

Osteoblastic Osteosarcoma
type: Class
definition: A conventional osteosarcoma characterized by the predominance of osteoid matrix.
Concept_In_Subset: NCIT C116977
Concept_In_Subset: NCIT C126659
code: C53953
Semantic_Type: Neoplastic Process
Display_Name: Osteoblastic Osteosarcoma
Preferred_Name: Osteoblastic Osteosarcoma
UMLS_CUI: C1704328
Contributing_Source: CTRP
Neoplastic_Status: Malignant
Legacy_Concept_Name: Osteoblastic_Osteosarcoma
has exact synonym: Osteoblastic Osteosarcoma
in subset: oncotree slim

Axiom
annotated source: Osteoblastic Osteosarcoma
annotated property: definition
annotated target: A conventional osteosarcoma characterized by the predominance of osteoid matrix.
def-source: NCI

Axiom
annotated source: Osteoblastic Osteosarcoma
annotated property: has exact synonym
annotated target: Osteoblastic Osteosarcoma
term-group: PT
term-source: NCI

High Grade Surface Osteosarcoma
type: Class
definition: A usually aggressive high grade malignant bone-forming mesenchymal neoplasm arising from the surface of the bone.
code: C53958
Semantic_Type: Neoplastic Process
Preferred_Name: High Grade Surface Osteosarcoma
UMLS_CUI: C1266165
ICD-O-3_Code: 9194/3
Neoplastic_Status: Malignant
Legacy_Concept_Name: High_Grade_Surface_Osteosarcoma
has exact synonym: High Grade Surface Osteosarcoma
in subset: oncotree slim

Axiom
annotated source: High Grade Surface Osteosarcoma
annotated property: definition
annotated target: A usually aggressive high grade malignant bone-forming mesenchymal neoplasm arising from the surface of the bone.
def-source: NCI

Axiom
annotated source: High Grade Surface Osteosarcoma
annotated property: has exact synonym
annotated target: High Grade Surface Osteosarcoma
term-group: PT
term-source: NCI

Erdheim-Chester Disease
type: Class
definition: A very rare, multisystem non-Langerhans cell histiocytosis that predominantly affects adults. It is characterized by the proliferation in the tissues of lipid-laden macrophages and the presence of multinucleated giant cells. It results in sclerosis of the long bones and failure of the affected organs. Patients may present with bone pain, exophthalmos, ataxia, liver failure, kidney failure, and hypopituitarism.
code: C53972
Semantic_Type: Disease or Syndrome
Preferred_Name: Erdheim-Chester Disease
UMLS_CUI: C0878675
Legacy_Concept_Name: Erdheim-Chester_Disease
has exact synonym: Erdheim-Chester Disease
has exact synonym: Lipogranulomatosis
has exact synonym: Polyostotic Sclerosing Histiocytosis
in subset: oncotree slim

Axiom
annotated source: Erdheim-Chester Disease
annotated property: definition
annotated target: A very rare, multisystem non-Langerhans cell histiocytosis that predominantly affects adults. It is characterized by the proliferation in the tissues of lipid-laden macrophages and the presence of multinucleated giant cells. It results in sclerosis of the long bones and failure of the affected organs. Patients may present with bone pain, exophthalmos, ataxia, liver failure, kidney failure, and hypopituitarism.
def-source: NCI

Axiom
annotated source: Erdheim-Chester Disease
annotated property: has exact synonym
annotated target: Erdheim-Chester Disease
term-group: PT
term-source: NCI

Axiom
annotated source: Erdheim-Chester Disease
annotated property: has exact synonym
annotated target: Lipogranulomatosis
term-group: SY
term-source: NCI

Axiom
annotated source: Erdheim-Chester Disease
annotated property: has exact synonym
annotated target: Polyostotic Sclerosing Histiocytosis
term-group: SY
term-source: NCI

Medulloblastoma with Extensive Nodularity
type: Class
subclass of: Medulloblastoma
definition: A medulloblastoma characterized by nodularity and neuronal differentiation.
Concept_In_Subset: NCIT C126659
code: C5407
Semantic_Type: Neoplastic Process
Preferred_Name: Medulloblastoma with Extensive Nodularity
UMLS_CUI: C1334970
ICD-O-3_Code: 9471/3
Neoplastic_Status: Malignant
Legacy_Concept_Name: Nodular_Medulloblastoma
has exact synonym: Cerebellar Neuroblastoma
has exact synonym: Medulloblastoma with Extensive Nodularity
has exact synonym: Medulloblastoma with Extensive Nodularity and Advanced Neuronal Differentiation
has exact synonym: Nodular Medulloblastoma
in subset: oncotree slim

Axiom
annotated source: Medulloblastoma with Extensive Nodularity
annotated property: definition
annotated target: A medulloblastoma characterized by nodularity and neuronal differentiation.
def-source: NCI

Axiom
annotated source: Medulloblastoma with Extensive Nodularity
annotated property: has exact synonym
annotated target: Cerebellar Neuroblastoma
term-group: SY
term-source: NCI

Axiom
annotated source: Medulloblastoma with Extensive Nodularity
annotated property: has exact synonym
annotated target: Medulloblastoma with Extensive Nodularity
term-group: PT
term-source: NCI

Axiom
annotated source: Medulloblastoma with Extensive Nodularity
annotated property: has exact synonym
annotated target: Medulloblastoma with Extensive Nodularity and Advanced Neuronal Differentiation
term-group: SY
term-source: NCI

Axiom
annotated source: Medulloblastoma with Extensive Nodularity
annotated property: has exact synonym
annotated target: Nodular Medulloblastoma
term-group: SY
term-source: NCI

Non-Keratinizing Sinonasal Squamous Cell Carcinoma
type: Class
definition: A squamous cell carcinoma of the sinonasal tract characterized by a plexiform or ribbon-like growth pattern, cytological atypia, and lack of histological evidence of keratinization.
code: C54287
Semantic_Type: Neoplastic Process
Preferred_Name: Non-Keratinizing Sinonasal Squamous Cell Carcinoma
UMLS_CUI: C0334270
ICD-O-3_Code: 8121/3
Neoplastic_Status: Malignant
Legacy_Concept_Name: Non-Keratinizing_Sinonasal_Squamous_Cell_Carcinoma
has exact synonym: Non-Keratinizing Sinonasal Squamous Cell Carcinoma
has exact synonym: Ringertz Carcinoma
has exact synonym: Schneiderian Carcinoma
has exact synonym: Sinonasal Cylindrical Cell Carcinoma
has exact synonym: Sinonasal Schneiderian Carcinoma
has exact synonym: Sinonasal Transitional Cell Carcinoma
in subset: oncotree slim

Axiom
annotated source: Non-Keratinizing Sinonasal Squamous Cell Carcinoma
annotated property: definition
annotated target: A squamous cell carcinoma of the sinonasal tract characterized by a plexiform or ribbon-like growth pattern, cytological atypia, and lack of histological evidence of keratinization.
def-source: NCI

Axiom
annotated source: Non-Keratinizing Sinonasal Squamous Cell Carcinoma
annotated property: has exact synonym
annotated target: Non-Keratinizing Sinonasal Squamous Cell Carcinoma
term-group: PT
term-source: NCI

Axiom
annotated source: Non-Keratinizing Sinonasal Squamous Cell Carcinoma
annotated property: has exact synonym
annotated target: Ringertz Carcinoma
term-group: SY
term-source: NCI

Axiom
annotated source: Non-Keratinizing Sinonasal Squamous Cell Carcinoma
annotated property: has exact synonym
annotated target: Schneiderian Carcinoma
term-group: SY
term-source: NCI

Axiom
annotated source: Non-Keratinizing Sinonasal Squamous Cell Carcinoma
annotated property: has exact synonym
annotated target: Sinonasal Cylindrical Cell Carcinoma
term-group: SY
term-source: NCI

Axiom
annotated source: Non-Keratinizing Sinonasal Squamous Cell Carcinoma
annotated property: has exact synonym
annotated target: Sinonasal Schneiderian Carcinoma
term-group: SY
term-source: NCI

Axiom
annotated source: Non-Keratinizing Sinonasal Squamous Cell Carcinoma
annotated property: has exact synonym
annotated target: Sinonasal Transitional Cell Carcinoma
term-group: SY
term-source: NCI

Clear Cell Odontogenic Carcinoma
type: Class
subclass of: Malignant Odontogenic Neoplasm
definition: A usually aggressive malignant neoplasm arising from tooth-forming tissues. It more often affects older females and more frequently occurs in the mandible. It is characterized by the presence of malignant epithelial cells with clear cytoplasm and a fibrotic stroma formation. It may recur and metastasize. Metastases may occur in the lymph nodes, lungs, and bones. Treatment of choice is resection with clean margins.
code: C54300
Semantic_Type: Neoplastic Process
Preferred_Name: Clear Cell Odontogenic Carcinoma
UMLS_CUI: C0475829
ICD-O-3_Code: 9341/1
ICD-O-3_Code: 9341/3
Neoplastic_Status: Malignant
Legacy_Concept_Name: Clear_Cell_Odontogenic_Carcinoma
has exact synonym: Clear Cell Ameloblastoma
has exact synonym: Clear Cell Odontogenic Carcinoma
has exact synonym: Clear Cell Odontogenic Tumor
in subset: oncotree slim

Axiom
annotated source: Clear Cell Odontogenic Carcinoma
annotated property: definition
annotated target: A usually aggressive malignant neoplasm arising from tooth-forming tissues. It more often affects older females and more frequently occurs in the mandible. It is characterized by the presence of malignant epithelial cells with clear cytoplasm and a fibrotic stroma formation. It may recur and metastasize. Metastases may occur in the lymph nodes, lungs, and bones. Treatment of choice is resection with clean margins.
def-source: NCI

Axiom
annotated source: Clear Cell Odontogenic Carcinoma
annotated property: has exact synonym
annotated target: Clear Cell Ameloblastoma
term-group: SY
term-source: NCI

Axiom
annotated source: Clear Cell Odontogenic Carcinoma
annotated property: has exact synonym
annotated target: Clear Cell Odontogenic Carcinoma
term-group: PT
term-source: NCI

Axiom
annotated source: Clear Cell Odontogenic Carcinoma
annotated property: has exact synonym
annotated target: Clear Cell Odontogenic Tumor
term-group: SY
term-source: NCI

Gastric Papillary Adenocarcinoma
type: Class
definition: A variant of gastric adenocarcinoma with exophytic growth and elongated finger-like processes lined by cylindrical or cuboidal cells supported by fibrovascular connective tissue cores.
code: C5472
Semantic_Type: Neoplastic Process
Preferred_Name: Gastric Papillary Adenocarcinoma
UMLS_CUI: C1333785
Neoplastic_Status: Malignant
Legacy_Concept_Name: Gastric_Papillary_Adenocarcinoma
has exact synonym: Gastric Papillary Adenocarcinoma
has exact synonym: Papillary Adenocarcinoma of Stomach
has exact synonym: Papillary Adenocarcinoma of the Stomach
in subset: oncotree slim

Axiom
annotated source: Gastric Papillary Adenocarcinoma
annotated property: definition
annotated target: A variant of gastric adenocarcinoma with exophytic growth and elongated finger-like processes lined by cylindrical or cuboidal cells supported by fibrovascular connective tissue cores.
def-source: NCI

Axiom
annotated source: Gastric Papillary Adenocarcinoma
annotated property: has exact synonym
annotated target: Gastric Papillary Adenocarcinoma
term-group: PT
term-source: NCI

Axiom
annotated source: Gastric Papillary Adenocarcinoma
annotated property: has exact synonym
annotated target: Gastric Papillary Adenocarcinoma
term-group: SY
term-source: NCI
source-code: TCGA
subsource-name: caDSR

Axiom
annotated source: Gastric Papillary Adenocarcinoma
annotated property: has exact synonym
annotated target: Papillary Adenocarcinoma of Stomach
term-group: SY
term-source: NCI

Axiom
annotated source: Gastric Papillary Adenocarcinoma
annotated property: has exact synonym
annotated target: Papillary Adenocarcinoma of the Stomach
term-group: SY
term-source: NCI

Gastric Tubular Adenocarcinoma
type: Class
definition: A variant of gastric adenocarcinoma characterized by prominent dilated or slit-like tubules.
code: C5473
Semantic_Type: Neoplastic Process
Preferred_Name: Gastric Tubular Adenocarcinoma
UMLS_CUI: C1333791
Neoplastic_Status: Malignant
Legacy_Concept_Name: Gastric_Tubular_Adenocarcinoma
has exact synonym: Gastric Tubular Adenocarcinoma
has exact synonym: Tubular Adenocarcinoma of Stomach
has exact synonym: Tubular Adenocarcinoma of the Stomach
in subset: oncotree slim

Axiom
annotated source: Gastric Tubular Adenocarcinoma
annotated property: definition
annotated target: A variant of gastric adenocarcinoma characterized by prominent dilated or slit-like tubules.
def-source: NCI

Axiom
annotated source: Gastric Tubular Adenocarcinoma
annotated property: has exact synonym
annotated target: Gastric Tubular Adenocarcinoma
term-group: PT
term-source: NCI

Axiom
annotated source: Gastric Tubular Adenocarcinoma
annotated property: has exact synonym
annotated target: Gastric Tubular Adenocarcinoma
term-group: SY
term-source: NCI
source-code: TCGA
subsource-name: caDSR

Axiom
annotated source: Gastric Tubular Adenocarcinoma
annotated property: has exact synonym
annotated target: Tubular Adenocarcinoma of Stomach
term-group: SY
term-source: NCI

Axiom
annotated source: Gastric Tubular Adenocarcinoma
annotated property: has exact synonym
annotated target: Tubular Adenocarcinoma of the Stomach
term-group: SY
term-source: NCI

Gastric Adenosquamous Carcinoma
type: Class
definition: A carcinoma that arises from the stomach and is characterized by the presence of malignant cells with glandular and squamous differentiation.
Concept_In_Subset: NCIT C126659
code: C5474
Semantic_Type: Neoplastic Process
Preferred_Name: Gastric Adenosquamous Carcinoma
UMLS_CUI: C1333761
Neoplastic_Status: Malignant
Legacy_Concept_Name: Gastric_Adenosquamous_Carcinoma
has exact synonym: Adenosquamous Carcinoma of Stomach
has exact synonym: Adenosquamous Carcinoma of the Stomach
has exact synonym: Gastric (Stomach) Adenosquamous Cancer
has exact synonym: Gastric Adenosquamous Carcinoma
in subset: oncotree slim

Axiom
annotated source: Gastric Adenosquamous Carcinoma
annotated property: definition
annotated target: A carcinoma that arises from the stomach and is characterized by the presence of malignant cells with glandular and squamous differentiation.
def-source: NCI

Axiom
annotated source: Gastric Adenosquamous Carcinoma
annotated property: has exact synonym
annotated target: Adenosquamous Carcinoma of Stomach
term-group: SY
term-source: NCI

Axiom
annotated source: Gastric Adenosquamous Carcinoma
annotated property: has exact synonym
annotated target: Adenosquamous Carcinoma of the Stomach
term-group: SY
term-source: NCI

Axiom
annotated source: Gastric Adenosquamous Carcinoma
annotated property: has exact synonym
annotated target: Gastric (Stomach) Adenosquamous Cancer
term-group: DN
term-source: CTRP

Axiom
annotated source: Gastric Adenosquamous Carcinoma
annotated property: has exact synonym
annotated target: Gastric Adenosquamous Carcinoma
term-group: PT
term-source: NCI

Undifferentiated Gastric Carcinoma
type: Class
definition: A carcinoma that arises from the stomach and is characterized by the absence of microscopic features of glandular or squamous differentiation.
Concept_In_Subset: NCIT C126659
code: C5476
Semantic_Type: Neoplastic Process
Preferred_Name: Undifferentiated Gastric Carcinoma
UMLS_CUI: C1336858
Neoplastic_Status: Malignant
Legacy_Concept_Name: Undifferentiated_Gastric_Carcinoma
has exact synonym: Anaplastic Carcinoma of Stomach
has exact synonym: Anaplastic Carcinoma of the Stomach
has exact synonym: Anaplastic Gastric Carcinoma
has exact synonym: Undifferentiated Carcinoma of Stomach
has exact synonym: Undifferentiated Carcinoma of the Stomach
has exact synonym: Undifferentiated Gastric (Stomach) Cancer
has exact synonym: Undifferentiated Gastric Carcinoma
in subset: oncotree slim

Axiom
annotated source: Undifferentiated Gastric Carcinoma
annotated property: definition
annotated target: A carcinoma that arises from the stomach and is characterized by the absence of microscopic features of glandular or squamous differentiation.
def-source: NCI

Axiom
annotated source: Undifferentiated Gastric Carcinoma
annotated property: has exact synonym
annotated target: Anaplastic Carcinoma of Stomach
term-group: SY
term-source: NCI

Axiom
annotated source: Undifferentiated Gastric Carcinoma
annotated property: has exact synonym
annotated target: Anaplastic Carcinoma of the Stomach
term-group: SY
term-source: NCI

Axiom
annotated source: Undifferentiated Gastric Carcinoma
annotated property: has exact synonym
annotated target: Anaplastic Gastric Carcinoma
term-group: SY
term-source: NCI

Axiom
annotated source: Undifferentiated Gastric Carcinoma
annotated property: has exact synonym
annotated target: Undifferentiated Carcinoma of Stomach
term-group: SY
term-source: NCI

Axiom
annotated source: Undifferentiated Gastric Carcinoma
annotated property: has exact synonym
annotated target: Undifferentiated Carcinoma of the Stomach
term-group: SY
term-source: NCI

Axiom
annotated source: Undifferentiated Gastric Carcinoma
annotated property: has exact synonym
annotated target: Undifferentiated Gastric (Stomach) Cancer
term-group: DN
term-source: CTRP

Axiom
annotated source: Undifferentiated Gastric Carcinoma
annotated property: has exact synonym
annotated target: Undifferentiated Gastric Carcinoma
term-group: PT
term-source: NCI

Prostate Neuroendocrine Neoplasm
type: Class
definition: A neoplasm with neuroendocrine differentiation that arises from the prostate gland. This category includes carcinoid tumors and small cell carcinomas.
code: C5545
Semantic_Type: Neoplastic Process
Preferred_Name: Prostate Neuroendocrine Neoplasm
UMLS_CUI: C1335515
Neoplastic_Status: Undetermined
Legacy_Concept_Name: Prostate_Neuroendocrine_Neoplasm
has exact synonym: Neuroendocrine Neoplasm of Prostate
has exact synonym: Neuroendocrine Neoplasm of the Prostate
has exact synonym: Prostate Neuroendocrine Neoplasm
in subset: oncotree slim

Axiom
annotated source: Prostate Neuroendocrine Neoplasm
annotated property: definition
annotated target: A neoplasm with neuroendocrine differentiation that arises from the prostate gland. This category includes carcinoid tumors and small cell carcinomas.
def-source: NCI

Axiom
annotated source: Prostate Neuroendocrine Neoplasm
annotated property: has exact synonym
annotated target: Neuroendocrine Neoplasm of Prostate
term-group: SY
term-source: NCI

Axiom
annotated source: Prostate Neuroendocrine Neoplasm
annotated property: has exact synonym
annotated target: Neuroendocrine Neoplasm of the Prostate
term-group: SY
term-source: NCI

Axiom
annotated source: Prostate Neuroendocrine Neoplasm
annotated property: has exact synonym
annotated target: Prostate Neuroendocrine Neoplasm
term-group: PT
term-source: NCI

Eccrine Porocarcinoma
type: Class
definition: A carcinoma with eccrine differentiation arising from the sweat glands. It may arise de novo or as a malignant transformation of a pre-existing poroma. It usually grows in the legs, buttocks, feet, and trunk and usually presents as an ulcerative plaque. It is characterized by the presence of intraepidermal and dermal nests of malignant epithelial cells. It may recur after excision and metastasize to the lymph nodes and less frequently to distal anatomic sites.
code: C5560
Semantic_Type: Neoplastic Process
Preferred_Name: Eccrine Porocarcinoma
UMLS_CUI: C1266065
ICD-O-3_Code: 8409/3
Neoplastic_Status: Malignant
Legacy_Concept_Name: Eccrine_Porocarcinoma
has exact synonym: Eccrine Porocarcinoma
has exact synonym: Epidermotropic Eccrine Carcinoma
has exact synonym: Malignant Eccrine Poroma
in subset: oncotree slim

Axiom
annotated source: Eccrine Porocarcinoma
annotated property: definition
annotated target: A carcinoma with eccrine differentiation arising from the sweat glands. It may arise de novo or as a malignant transformation of a pre-existing poroma. It usually grows in the legs, buttocks, feet, and trunk and usually presents as an ulcerative plaque. It is characterized by the presence of intraepidermal and dermal nests of malignant epithelial cells. It may recur after excision and metastasize to the lymph nodes and less frequently to distal anatomic sites.
def-source: NCI

Axiom
annotated source: Eccrine Porocarcinoma
annotated property: has exact synonym
annotated target: Eccrine Porocarcinoma
term-group: PT
term-source: NCI

Axiom
annotated source: Eccrine Porocarcinoma
annotated property: has exact synonym
annotated target: Epidermotropic Eccrine Carcinoma
term-group: SY
term-source: NCI

Axiom
annotated source: Eccrine Porocarcinoma
annotated property: has exact synonym
annotated target: Malignant Eccrine Poroma
term-group: SY
term-source: NCI

Chordoid Glioma of the Third Ventricle
type: Class
definition: A rare, slow-growing neuroepithelial neoplasm of uncertain origin affecting adults. It is located in the third ventricle. It is characterized by the presence of epithelioid cells which express GFAP, and mucinous stroma which contains lymphoplasmacytic infiltrates.
code: C5592
Semantic_Type: Neoplastic Process
Preferred_Name: Chordoid Glioma of the Third Ventricle
UMLS_CUI: C1322252
ICD-O-3_Code: 9444/1
Neoplastic_Status: Undetermined
Legacy_Concept_Name: Chordoid_Glioma
has exact synonym: Chordoid Glioma
has exact synonym: Chordoid Glioma of 3rd Ventricle
has exact synonym: Chordoid Glioma of Third Ventricle
has exact synonym: Chordoid Glioma of the 3rd Ventricle
has exact synonym: Chordoid Glioma of the Third Ventricle
has exact synonym: Chordoid Glioma of the Third Ventricle (WHO Grade II)
has exact synonym: Third Ventricle Chordoid Glioma
in subset: oncotree slim

Axiom
annotated source: Chordoid Glioma of the Third Ventricle
annotated property: definition
annotated target: A rare, slow-growing neuroepithelial neoplasm of uncertain origin affecting adults. It is located in the third ventricle. It is characterized by the presence of epithelioid cells which express GFAP, and mucinous stroma which contains lymphoplasmacytic infiltrates.
def-source: NCI

Axiom
annotated source: Chordoid Glioma of the Third Ventricle
annotated property: has exact synonym
annotated target: Chordoid Glioma
term-group: SY
term-source: NCI

Axiom
annotated source: Chordoid Glioma of the Third Ventricle
annotated property: has exact synonym
annotated target: Chordoid Glioma of 3rd Ventricle
term-group: SY
term-source: NCI

Axiom
annotated source: Chordoid Glioma of the Third Ventricle
annotated property: has exact synonym
annotated target: Chordoid Glioma of Third Ventricle
term-group: SY
term-source: NCI

Axiom
annotated source: Chordoid Glioma of the Third Ventricle
annotated property: has exact synonym
annotated target: Chordoid Glioma of the 3rd Ventricle
term-group: SY
term-source: NCI

Axiom
annotated source: Chordoid Glioma of the Third Ventricle
annotated property: has exact synonym
annotated target: Chordoid Glioma of the Third Ventricle
term-group: PT
term-source: NCI

Axiom
annotated source: Chordoid Glioma of the Third Ventricle
annotated property: has exact synonym
annotated target: Chordoid Glioma of the Third Ventricle (WHO Grade II)
term-group: SY
term-source: NCI

Axiom
annotated source: Chordoid Glioma of the Third Ventricle
annotated property: has exact synonym
annotated target: Third Ventricle Chordoid Glioma
term-group: SY
term-source: NCI

Lung Adenoid Cystic Carcinoma
type: Class
subclass of: Adenoid Cystic Carcinoma
definition: A rare usually indolent lung carcinoma characterized by a cribiform and tubular pattern and the presence of glandular epithelial cells. Clinical symptoms include shortness of breath, cough, wheeze, hemopytsis and chest pain.
Concept_In_Subset: NCIT C126659
code: C5666
Semantic_Type: Neoplastic Process
Preferred_Name: Lung Adenoid Cystic Carcinoma
UMLS_CUI: C1334439
Neoplastic_Status: Malignant
Legacy_Concept_Name: Lung_Adenoid_Cystic_Carcinoma
has exact synonym: Adenocystic Carcinoma of Lung
has exact synonym: Adenocystic Carcinoma of the Lung
has exact synonym: Adenoid Cystic Carcinoma of Lung
has exact synonym: Adenoid Cystic Carcinoma of the Lung
has exact synonym: Lung Adenocystic Carcinoma
has exact synonym: Lung Adenoid Cystic Cancer
has exact synonym: Lung Adenoid Cystic Carcinoma
has exact synonym: Pulmonary Adenocystic Carcinoma
has exact synonym: Pulmonary Adenoid Cystic Carcinoma
in subset: oncotree slim

Axiom
annotated source: Lung Adenoid Cystic Carcinoma
annotated property: definition
annotated target: A rare usually indolent lung carcinoma characterized by a cribiform and tubular pattern and the presence of glandular epithelial cells. Clinical symptoms include shortness of breath, cough, wheeze, hemopytsis and chest pain.
def-source: NCI

Axiom
annotated source: Lung Adenoid Cystic Carcinoma
annotated property: has exact synonym
annotated target: Adenocystic Carcinoma of Lung
term-group: SY
term-source: NCI

Axiom
annotated source: Lung Adenoid Cystic Carcinoma
annotated property: has exact synonym
annotated target: Adenocystic Carcinoma of the Lung
term-group: SY
term-source: NCI

Axiom
annotated source: Lung Adenoid Cystic Carcinoma
annotated property: has exact synonym
annotated target: Adenoid Cystic Carcinoma of Lung
term-group: SY
term-source: NCI

Axiom
annotated source: Lung Adenoid Cystic Carcinoma
annotated property: has exact synonym
annotated target: Adenoid Cystic Carcinoma of the Lung
term-group: SY
term-source: NCI

Axiom
annotated source: Lung Adenoid Cystic Carcinoma
annotated property: has exact synonym
annotated target: Lung Adenocystic Carcinoma
term-group: SY
term-source: NCI

Axiom
annotated source: Lung Adenoid Cystic Carcinoma
annotated property: has exact synonym
annotated target: Lung Adenoid Cystic Cancer
term-group: DN
term-source: CTRP

Axiom
annotated source: Lung Adenoid Cystic Carcinoma
annotated property: has exact synonym
annotated target: Lung Adenoid Cystic Carcinoma
term-group: PT
term-source: NCI

Axiom
annotated source: Lung Adenoid Cystic Carcinoma
annotated property: has exact synonym
annotated target: Pulmonary Adenocystic Carcinoma
term-group: SY
term-source: NCI

Axiom
annotated source: Lung Adenoid Cystic Carcinoma
annotated property: has exact synonym
annotated target: Pulmonary Adenoid Cystic Carcinoma
term-group: SY
term-source: NCI

Esophageal Melanoma
type: Class
definition: A melanoma affecting the esophageal wall. Melanoma in the esophagus is more commonly metastatic than primary. Primary melanomas of the esophagus are polypoid and clinically aggressive. (WHO, 2000)
code: C5707
Semantic_Type: Neoplastic Process
Preferred_Name: Esophageal Melanoma
UMLS_CUI: C1333460
Neoplastic_Status: Malignant
Legacy_Concept_Name: Esophageal_Melanoma
has exact synonym: Esophageal Melanoma
has exact synonym: Esophagus Melanoma
has exact synonym: Melanoma of Esophagus
has exact synonym: Melanoma of the Esophagus
in subset: oncotree slim

Axiom
annotated source: Esophageal Melanoma
annotated property: definition
annotated target: A melanoma affecting the esophageal wall. Melanoma in the esophagus is more commonly metastatic than primary. Primary melanomas of the esophagus are polypoid and clinically aggressive. (WHO, 2000)
def-source: NCI

Axiom
annotated source: Esophageal Melanoma
annotated property: has exact synonym
annotated target: Esophageal Melanoma
term-group: PT
term-source: NCI

Axiom
annotated source: Esophageal Melanoma
annotated property: has exact synonym
annotated target: Esophagus Melanoma
term-group: SY
term-source: NCI

Axiom
annotated source: Esophageal Melanoma
annotated property: has exact synonym
annotated target: Melanoma of Esophagus
term-group: SY
term-source: NCI

Axiom
annotated source: Esophageal Melanoma
annotated property: has exact synonym
annotated target: Melanoma of the Esophagus
term-group: SY
term-source: NCI

Pancreatic Serous Cystadenoma
type: Class
definition: A benign, non-metastasizing cystic epithelial neoplasm arising from the exocrine pancreas. It is composed of glycogen-rich epithelial cells which produce a watery fluid. Signs and symptoms include abdominal mass, abdominal pain, nausea, vomiting, and weight loss.
Concept_In_Subset: NCIT C126659
code: C5712
Semantic_Type: Neoplastic Process
Preferred_Name: Pancreatic Serous Cystadenoma
UMLS_CUI: C1335316
Neoplastic_Status: Benign
Legacy_Concept_Name: Pancreatic_Serous_Cystadenoma
has exact synonym: Pancreatic Microcystic Adenoma
has exact synonym: Pancreatic Serous Cystadenoma
has exact synonym: Serous Cystadenoma of Pancreas
has exact synonym: Serous Cystadenoma of the Pancreas
in subset: oncotree slim

Axiom
annotated source: Pancreatic Serous Cystadenoma
annotated property: definition
annotated target: A benign, non-metastasizing cystic epithelial neoplasm arising from the exocrine pancreas. It is composed of glycogen-rich epithelial cells which produce a watery fluid. Signs and symptoms include abdominal mass, abdominal pain, nausea, vomiting, and weight loss.
def-source: NCI

Axiom
annotated source: Pancreatic Serous Cystadenoma
annotated property: has exact synonym
annotated target: Pancreatic Microcystic Adenoma
term-group: SY
term-source: NCI

Axiom
annotated source: Pancreatic Serous Cystadenoma
annotated property: has exact synonym
annotated target: Pancreatic Serous Cystadenoma
term-group: PT
term-source: NCI

Axiom
annotated source: Pancreatic Serous Cystadenoma
annotated property: has exact synonym
annotated target: Serous Cystadenoma of Pancreas
term-group: SY
term-source: NCI

Axiom
annotated source: Pancreatic Serous Cystadenoma
annotated property: has exact synonym
annotated target: Serous Cystadenoma of the Pancreas
term-group: SY
term-source: NCI

Pancreatic Adenosquamous Carcinoma
type: Class
definition: A carcinoma that arises from the pancreas showing both ductal and squamous differentiation. The squamous component should represent at least 30% of the malignant cellular infiltrate. The prognosis is usually worse than that of ductal adenocarcinoma.
code: C5721
Semantic_Type: Neoplastic Process
Preferred_Name: Pancreatic Adenosquamous Carcinoma
UMLS_CUI: C1335299
Neoplastic_Status: Malignant
Legacy_Concept_Name: Pancreatic_Adenosquamous_Carcinoma
has exact synonym: Adenosquamous Carcinoma of Pancreas
has exact synonym: Adenosquamous Carcinoma of the Pancreas
has exact synonym: Pancreatic Adenoacanthoma
has exact synonym: Pancreatic Adenosquamous Cancer
has exact synonym: Pancreatic Adenosquamous Carcinoma
has exact synonym: Pancreatic Mixed Squamous and Adenocarcinoma
has exact synonym: Pancreatic Mucoepidermoid Carcinoma
in subset: oncotree slim

Axiom
annotated source: Pancreatic Adenosquamous Carcinoma
annotated property: definition
annotated target: A carcinoma that arises from the pancreas showing both ductal and squamous differentiation. The squamous component should represent at least 30% of the malignant cellular infiltrate. The prognosis is usually worse than that of ductal adenocarcinoma.
def-source: NCI

Axiom
annotated source: Pancreatic Adenosquamous Carcinoma
annotated property: has exact synonym
annotated target: Adenosquamous Carcinoma of Pancreas
term-group: SY
term-source: NCI

Axiom
annotated source: Pancreatic Adenosquamous Carcinoma
annotated property: has exact synonym
annotated target: Adenosquamous Carcinoma of the Pancreas
term-group: SY
term-source: NCI

Axiom
annotated source: Pancreatic Adenosquamous Carcinoma
annotated property: has exact synonym
annotated target: Pancreatic Adenoacanthoma
term-group: SY
term-source: NCI

Axiom
annotated source: Pancreatic Adenosquamous Carcinoma
annotated property: has exact synonym
annotated target: Pancreatic Adenosquamous Cancer
term-group: DN
term-source: CTRP

Axiom
annotated source: Pancreatic Adenosquamous Carcinoma
annotated property: has exact synonym
annotated target: Pancreatic Adenosquamous Carcinoma
term-group: PT
term-source: NCI

Axiom
annotated source: Pancreatic Adenosquamous Carcinoma
annotated property: has exact synonym
annotated target: Pancreatic Mixed Squamous and Adenocarcinoma
term-group: SY
term-source: NCI

Axiom
annotated source: Pancreatic Adenosquamous Carcinoma
annotated property: has exact synonym
annotated target: Pancreatic Mucoepidermoid Carcinoma
term-group: SY
term-source: NCI

Undifferentiated Pancreatic Carcinoma
type: Class
definition: A carcinoma with poor prognosis that arises from the pancreas. It is characterized by the presence of a significant malignant component that does not show differentiation. The malignant cells represent a mixture of large, pleomorphic cells and giant cells, or adenocarcinoma cells and spindle cells, or spindle cells.
code: C5722
Semantic_Type: Neoplastic Process
Preferred_Name: Undifferentiated Pancreatic Carcinoma
UMLS_CUI: C1336861
Neoplastic_Status: Malignant
Legacy_Concept_Name: Undifferentiated_Pancreatic_Carcinoma
has exact synonym: Pancreatic Carcinosarcoma
has exact synonym: Pleomorphic Large Cell Pancreatic Carcinoma
has exact synonym: Sarcomatoid Pancreatic Carcinoma
has exact synonym: Spindle Cell Pancreatic Carcinoma
has exact synonym: Undifferentiated (Anaplastic) Pancreatic Carcinoma
has exact synonym: Undifferentiated Carcinoma of Pancreas
has exact synonym: Undifferentiated Carcinoma of the Pancreas
has exact synonym: Undifferentiated Pancreatic Carcinoma
in subset: oncotree slim

Axiom
annotated source: Undifferentiated Pancreatic Carcinoma
annotated property: definition
annotated target: A carcinoma with poor prognosis that arises from the pancreas. It is characterized by the presence of a significant malignant component that does not show differentiation. The malignant cells represent a mixture of large, pleomorphic cells and giant cells, or adenocarcinoma cells and spindle cells, or spindle cells.
def-source: NCI

Axiom
annotated source: Undifferentiated Pancreatic Carcinoma
annotated property: has exact synonym
annotated target: Pancreatic Carcinosarcoma
term-group: SY
term-source: NCI

Axiom
annotated source: Undifferentiated Pancreatic Carcinoma
annotated property: has exact synonym
annotated target: Pleomorphic Large Cell Pancreatic Carcinoma
term-group: SY
term-source: NCI

Axiom
annotated source: Undifferentiated Pancreatic Carcinoma
annotated property: has exact synonym
annotated target: Sarcomatoid Pancreatic Carcinoma
term-group: SY
term-source: NCI

Axiom
annotated source: Undifferentiated Pancreatic Carcinoma
annotated property: has exact synonym
annotated target: Spindle Cell Pancreatic Carcinoma
term-group: SY
term-source: NCI

Axiom
annotated source: Undifferentiated Pancreatic Carcinoma
annotated property: has exact synonym
annotated target: Undifferentiated (Anaplastic) Pancreatic Carcinoma
term-group: SY
term-source: NCI

Axiom
annotated source: Undifferentiated Pancreatic Carcinoma
annotated property: has exact synonym
annotated target: Undifferentiated Carcinoma of Pancreas
term-group: SY
term-source: NCI

Axiom
annotated source: Undifferentiated Pancreatic Carcinoma
annotated property: has exact synonym
annotated target: Undifferentiated Carcinoma of the Pancreas
term-group: SY
term-source: NCI

Axiom
annotated source: Undifferentiated Pancreatic Carcinoma
annotated property: has exact synonym
annotated target: Undifferentiated Pancreatic Carcinoma
term-group: PT
term-source: NCI

Axiom
annotated source: Undifferentiated Pancreatic Carcinoma
annotated property: has exact synonym
annotated target: Undifferentiated Pancreatic Carcinoma
term-group: SY
term-source: NCI
source-code: TCGA
subsource-name: caDSR

Childhood Brain Germ Cell Tumor
type: Class
definition: A germ cell tumor arising from brain during childhood.
Concept_In_Subset: NCIT C116977
code: C5795
Semantic_Type: Neoplastic Process
Display_Name: Childhood Brain Germ Cell Tumor
Preferred_Name: Childhood Brain Germ Cell Tumor
NCI_META_CUI: CL448320
Contributing_Source: CTRP
Neoplastic_Status: Undetermined
Legacy_Concept_Name: Childhood_Brain_Germ_Cell_Neoplasm
has exact synonym: Childhood Brain Germ Cell Neoplasm
has exact synonym: Childhood Brain Germ Cell Tumor
has exact synonym: Childhood Germ Cell Brain Neoplasm
has exact synonym: Childhood Germ Cell Brain Tumor
has exact synonym: Germ Cell Neoplasm of Childhood Brain
has exact synonym: Germ Cell Neoplasm of Pediatric Brain
has exact synonym: Germ Cell Neoplasm of the Childhood Brain
has exact synonym: Germ Cell Neoplasm of the Pediatric Brain
has exact synonym: Germ Cell Tumor of Childhood Brain
has exact synonym: Germ Cell Tumor of Pediatric Brain
has exact synonym: Germ Cell Tumor of the Childhood Brain
has exact synonym: Germ Cell Tumor of the Pediatric Brain
has exact synonym: Pediatric Brain Germ Cell Neoplasm
has exact synonym: Pediatric Brain Germ Cell Tumor
in subset: oncotree slim

Axiom
annotated source: Childhood Brain Germ Cell Tumor
annotated property: definition
annotated target: A germ cell tumor arising from brain during childhood.
def-source: NCI

Axiom
annotated source: Childhood Brain Germ Cell Tumor
annotated property: has exact synonym
annotated target: Childhood Brain Germ Cell Neoplasm
term-group: SY
term-source: NCI

Axiom
annotated source: Childhood Brain Germ Cell Tumor
annotated property: has exact synonym
annotated target: Childhood Brain Germ Cell Tumor
term-group: PT
term-source: NCI

Axiom
annotated source: Childhood Brain Germ Cell Tumor
annotated property: has exact synonym
annotated target: Childhood Germ Cell Brain Neoplasm
term-group: SY
term-source: NCI

Axiom
annotated source: Childhood Brain Germ Cell Tumor
annotated property: has exact synonym
annotated target: Childhood Germ Cell Brain Tumor
term-group: SY
term-source: NCI

Axiom
annotated source: Childhood Brain Germ Cell Tumor
annotated property: has exact synonym
annotated target: Germ Cell Neoplasm of Childhood Brain
term-group: SY
term-source: NCI

Axiom
annotated source: Childhood Brain Germ Cell Tumor
annotated property: has exact synonym
annotated target: Germ Cell Neoplasm of Pediatric Brain
term-group: SY
term-source: NCI

Axiom
annotated source: Childhood Brain Germ Cell Tumor
annotated property: has exact synonym
annotated target: Germ Cell Neoplasm of the Childhood Brain
term-group: SY
term-source: NCI

Axiom
annotated source: Childhood Brain Germ Cell Tumor
annotated property: has exact synonym
annotated target: Germ Cell Neoplasm of the Pediatric Brain
term-group: SY
term-source: NCI

Axiom
annotated source: Childhood Brain Germ Cell Tumor
annotated property: has exact synonym
annotated target: Germ Cell Tumor of Childhood Brain
term-group: SY
term-source: NCI

Axiom
annotated source: Childhood Brain Germ Cell Tumor
annotated property: has exact synonym
annotated target: Germ Cell Tumor of Pediatric Brain
term-group: SY
term-source: NCI

Axiom
annotated source: Childhood Brain Germ Cell Tumor
annotated property: has exact synonym
annotated target: Germ Cell Tumor of the Childhood Brain
term-group: SY
term-source: NCI

Axiom
annotated source: Childhood Brain Germ Cell Tumor
annotated property: has exact synonym
annotated target: Germ Cell Tumor of the Pediatric Brain
term-group: SY
term-source: NCI

Axiom
annotated source: Childhood Brain Germ Cell Tumor
annotated property: has exact synonym
annotated target: Pediatric Brain Germ Cell Neoplasm
term-group: SY
term-source: NCI

Axiom
annotated source: Childhood Brain Germ Cell Tumor
annotated property: has exact synonym
annotated target: Pediatric Brain Germ Cell Tumor
term-group: SY
term-source: NCI

Salivary Duct Carcinoma
type: Class
subclass of: NCIT C8021
definition: An aggressive, high grade adenocarcinoma that arises from the salivary glands. It usually affects elderly males and presents as a rapidly enlarging mass. It metastasizes to regional lymph nodes and distant anatomic sites.
code: C5904
Semantic_Type: Neoplastic Process
Preferred_Name: Salivary Duct Carcinoma
UMLS_CUI: C1301194
Neoplastic_Status: Malignant
Legacy_Concept_Name: Salivary_Duct_Carcinoma
has exact synonym: Carcinoma of Salivary Duct
has exact synonym: Carcinoma of the Salivary Duct
has exact synonym: High Grade Salivary Duct Carcinoma
has exact synonym: Salivary Duct Carcinoma
in subset: oncotree slim

Axiom
annotated source: Salivary Duct Carcinoma
annotated property: definition
annotated target: An aggressive, high grade adenocarcinoma that arises from the salivary glands. It usually affects elderly males and presents as a rapidly enlarging mass. It metastasizes to regional lymph nodes and distant anatomic sites.
def-source: NCI

Axiom
annotated source: Salivary Duct Carcinoma
annotated property: has exact synonym
annotated target: Carcinoma of Salivary Duct
term-group: SY
term-source: NCI

Axiom
annotated source: Salivary Duct Carcinoma
annotated property: has exact synonym
annotated target: Carcinoma of the Salivary Duct
term-group: SY
term-source: NCI

Axiom
annotated source: Salivary Duct Carcinoma
annotated property: has exact synonym
annotated target: High Grade Salivary Duct Carcinoma
term-group: SY
term-source: NCI

Axiom
annotated source: Salivary Duct Carcinoma
annotated property: has exact synonym
annotated target: Salivary Duct Carcinoma
term-group: PT
term-source: NCI

Poorly Differentiated Thyroid Gland Carcinoma
type: Class
definition: An adenocarcinoma arising from the thyroid gland showing only limited evidence of follicular cell differentiation. Microscopically, the adenocarcinoma cells are arranged in insular, solid, and trabecular patterns. There is associated necrosis, and vascular invasion. The prognosis depends on the tumor stage, complete or partial surgical removal of the tumor, and the degree of response to radioactive iodine therapy (adapted from WHO Tumors of Endocrine Organs, IARC Press, Lyon 2004)
Concept_In_Subset: NCIT C116977
Concept_In_Subset: NCIT C126659
code: C6040
Semantic_Type: Neoplastic Process
Display_Name: Poorly Differentiated Thyroid Gland Cancer
Preferred_Name: Poorly Differentiated Thyroid Gland Carcinoma
UMLS_CUI: C1266050
Contributing_Source: CTRP
ICD-O-3_Code: 8337/3
Neoplastic_Status: Malignant
Legacy_Concept_Name: Poorly_Differentiated_Thyroid_Carcinoma
has exact synonym: Insular Carcinoma
has exact synonym: Poorly Differentiated Carcinoma of Thyroid Gland
has exact synonym: Poorly Differentiated Carcinoma of the Thyroid Gland
has exact synonym: Poorly Differentiated Thyroid Carcinoma
has exact synonym: Poorly Differentiated Thyroid Gland Carcinoma
has exact synonym: Thyroid Gland Poorly Differentiated Carcinoma
in subset: oncotree slim

Axiom
annotated source: Poorly Differentiated Thyroid Gland Carcinoma
annotated property: definition
annotated target: An adenocarcinoma arising from the thyroid gland showing only limited evidence of follicular cell differentiation. Microscopically, the adenocarcinoma cells are arranged in insular, solid, and trabecular patterns. There is associated necrosis, and vascular invasion. The prognosis depends on the tumor stage, complete or partial surgical removal of the tumor, and the degree of response to radioactive iodine therapy (adapted from WHO Tumors of Endocrine Organs, IARC Press, Lyon 2004)
def-source: NCI

Axiom
annotated source: Poorly Differentiated Thyroid Gland Carcinoma
annotated property: has exact synonym
annotated target: Insular Carcinoma
term-group: SY
term-source: NCI

Axiom
annotated source: Poorly Differentiated Thyroid Gland Carcinoma
annotated property: has exact synonym
annotated target: Poorly Differentiated Carcinoma of Thyroid Gland
term-group: SY
term-source: NCI

Axiom
annotated source: Poorly Differentiated Thyroid Gland Carcinoma
annotated property: has exact synonym
annotated target: Poorly Differentiated Carcinoma of the Thyroid Gland
term-group: SY
term-source: NCI

Axiom
annotated source: Poorly Differentiated Thyroid Gland Carcinoma
annotated property: has exact synonym
annotated target: Poorly Differentiated Thyroid Carcinoma
term-group: SY
term-source: NCI

Axiom
annotated source: Poorly Differentiated Thyroid Gland Carcinoma
annotated property: has exact synonym
annotated target: Poorly Differentiated Thyroid Gland Carcinoma
term-group: PT
term-source: NCI

Axiom
annotated source: Poorly Differentiated Thyroid Gland Carcinoma
annotated property: has exact synonym
annotated target: Thyroid Gland Poorly Differentiated Carcinoma
term-group: SY
term-source: NCI

Astrocytoma
type: Class
definition: A tumor of the brain or spinal cord showing astrocytic differentiation. It includes the following clinicopathological entities: pilocytic astrocytoma, diffuse astrocytoma, anaplastic astrocytoma, pleomorphic xanthoastrocytoma, and subependymal giant cell astrocytoma.
Has_NICHD_Parent: NCIT C3268
Concept_In_Subset: NCIT C118464
Concept_In_Subset: NCIT C126659
Concept_In_Subset: NCIT C90259
code: C60781
Semantic_Type: Neoplastic Process
Preferred_Name: Astrocytoma
UMLS_CUI: C0004114
Contributing_Source: MedDRA
Contributing_Source: NICHD
ALT_DEFINITION: A malignant neoplasm of the central nervous system that arises from astrocytes.
ALT_DEFINITION: A tumor that begins in the brain or spinal cord in small, star-shaped cells called astrocytes.
ICD-O-3_Code: 9400/3
Neoplastic_Status: Undetermined
Legacy_Concept_Name: Astrocytoma
NICHD_Hierarchy_Term: Astrocytoma
has exact synonym: Astrocytoma
has exact synonym: astrocytoma
in subset: oncotree slim

Axiom
annotated source: Astrocytoma
annotated property: definition
annotated target: A tumor of the brain or spinal cord showing astrocytic differentiation. It includes the following clinicopathological entities: pilocytic astrocytoma, diffuse astrocytoma, anaplastic astrocytoma, pleomorphic xanthoastrocytoma, and subependymal giant cell astrocytoma.
def-source: NCI

Axiom
annotated source: Astrocytoma
annotated property: ALT_DEFINITION
annotated target: A malignant neoplasm of the central nervous system that arises from astrocytes.
def-source: NICHD

Axiom
annotated source: Astrocytoma
annotated property: ALT_DEFINITION
annotated target: A tumor that begins in the brain or spinal cord in small, star-shaped cells called astrocytes.
def-source: NCI-GLOSS

Axiom
annotated source: Astrocytoma
annotated property: has exact synonym
annotated target: Astrocytoma
term-group: PT
term-source: CTRP

Axiom
annotated source: Astrocytoma
annotated property: has exact synonym
annotated target: Astrocytoma
term-group: PT
term-source: NCI

Axiom
annotated source: Astrocytoma
annotated property: has exact synonym
annotated target: Astrocytoma
term-group: PT
term-source: NICHD

Axiom
annotated source: Astrocytoma
annotated property: has exact synonym
annotated target: Astrocytoma
term-group: SY
term-source: NCI
source-code: TCGA
subsource-name: caDSR

Axiom
annotated source: Astrocytoma
annotated property: has exact synonym
annotated target: astrocytoma
term-group: PT
term-source: NCI-GLOSS
source-code: CDR0000045602

Urethral Squamous Cell Carcinoma
type: Class
subclass of: NCIT C9106
definition: A well differentiated, moderately differentiated, or poorly differentiated squamous cell carcinoma that arises from the male or female urethra.
Concept_In_Subset: NCIT C126659
code: C6165
Semantic_Type: Neoplastic Process
Preferred_Name: Urethral Squamous Cell Carcinoma
UMLS_CUI: C1336890
Neoplastic_Status: Malignant
Legacy_Concept_Name: Urethral_Squamous_Cell_Carcinoma
has exact synonym: Epidermoid Carcinoma of Urethra
has exact synonym: Epidermoid Carcinoma of the Urethra
has exact synonym: Squamous Cell Carcinoma of Urethra
has exact synonym: Squamous Cell Carcinoma of the Urethra
has exact synonym: Urethra Epidermoid Carcinoma
has exact synonym: Urethra Squamous Cell Carcinoma
has exact synonym: Urethral Epidermoid Carcinoma
has exact synonym: Urethral Squamous Cell Cancer
has exact synonym: Urethral Squamous Cell Carcinoma
in subset: oncotree slim

Axiom
annotated source: Urethral Squamous Cell Carcinoma
annotated property: definition
annotated target: A well differentiated, moderately differentiated, or poorly differentiated squamous cell carcinoma that arises from the male or female urethra.
def-source: NCI

Axiom
annotated source: Urethral Squamous Cell Carcinoma
annotated property: has exact synonym
annotated target: Epidermoid Carcinoma of Urethra
term-group: SY
term-source: NCI

Axiom
annotated source: Urethral Squamous Cell Carcinoma
annotated property: has exact synonym
annotated target: Epidermoid Carcinoma of the Urethra
term-group: SY
term-source: NCI

Axiom
annotated source: Urethral Squamous Cell Carcinoma
annotated property: has exact synonym
annotated target: Squamous Cell Carcinoma of Urethra
term-group: SY
term-source: NCI

Axiom
annotated source: Urethral Squamous Cell Carcinoma
annotated property: has exact synonym
annotated target: Squamous Cell Carcinoma of the Urethra
term-group: SY
term-source: NCI

Axiom
annotated source: Urethral Squamous Cell Carcinoma
annotated property: has exact synonym
annotated target: Urethra Epidermoid Carcinoma
term-group: SY
term-source: NCI

Axiom
annotated source: Urethral Squamous Cell Carcinoma
annotated property: has exact synonym
annotated target: Urethra Squamous Cell Carcinoma
term-group: SY
term-source: NCI

Axiom
annotated source: Urethral Squamous Cell Carcinoma
annotated property: has exact synonym
annotated target: Urethral Epidermoid Carcinoma
term-group: SY
term-source: NCI

Axiom
annotated source: Urethral Squamous Cell Carcinoma
annotated property: has exact synonym
annotated target: Urethral Squamous Cell Cancer
term-group: DN
term-source: CTRP

Axiom
annotated source: Urethral Squamous Cell Carcinoma
annotated property: has exact synonym
annotated target: Urethral Squamous Cell Carcinoma
term-group: PT
term-source: NCI

Urethral Adenocarcinoma
type: Class
subclass of: NCIT C9106
definition: An adenocarcinoma that arises from the male or female urethra.
Concept_In_Subset: NCIT C126659
code: C6167
Semantic_Type: Neoplastic Process
Preferred_Name: Urethral Adenocarcinoma
UMLS_CUI: C1336885
Neoplastic_Status: Malignant
Legacy_Concept_Name: Urethral_Adenocarcinoma
has exact synonym: Adenocarcinoma of Urethra
has exact synonym: Adenocarcinoma of the Urethra
has exact synonym: Urethra Adenocarcinoma
has exact synonym: Urethral Adenocarcinoma
in subset: oncotree slim

Axiom
annotated source: Urethral Adenocarcinoma
annotated property: definition
annotated target: An adenocarcinoma that arises from the male or female urethra.
def-source: NCI

Axiom
annotated source: Urethral Adenocarcinoma
annotated property: has exact synonym
annotated target: Adenocarcinoma of Urethra
term-group: SY
term-source: NCI

Axiom
annotated source: Urethral Adenocarcinoma
annotated property: has exact synonym
annotated target: Adenocarcinoma of the Urethra
term-group: SY
term-source: NCI

Axiom
annotated source: Urethral Adenocarcinoma
annotated property: has exact synonym
annotated target: Urethra Adenocarcinoma
term-group: SY
term-source: NCI

Axiom
annotated source: Urethral Adenocarcinoma
annotated property: has exact synonym
annotated target: Urethral Adenocarcinoma
term-group: DN
term-source: CTRP

Axiom
annotated source: Urethral Adenocarcinoma
annotated property: has exact synonym
annotated target: Urethral Adenocarcinoma
term-group: PT
term-source: NCI

Bladder Inflammatory Myofibroblastic Tumor
type: Class
subclass of: Inflammatory Myofibroblastic Tumor
definition: A multinodular intermediate fibroblastic neoplasm arising from the bladder. It is characterized by the presence of spindle-shaped fibroblasts and myofibroblasts, and a chronic inflammatory infiltrate composed of eosinophils, lymphocytes and plasma cells.
code: C6177
Semantic_Type: Neoplastic Process
Preferred_Name: Bladder Inflammatory Myofibroblastic Tumor
UMLS_CUI: C1336891
Neoplastic_Status: Undetermined
Legacy_Concept_Name: Urinary_Bladder_Inflammatory_Myofibroblastic_Tumor
has exact synonym: Bladder Inflammatory Myofibroblastic Neoplasm
has exact synonym: Bladder Inflammatory Myofibroblastic Tumor
has exact synonym: Inflammatory Myofibroblastic Neoplasm of Bladder
has exact synonym: Inflammatory Myofibroblastic Neoplasm of Urinary Bladder
has exact synonym: Inflammatory Myofibroblastic Neoplasm of the Bladder
has exact synonym: Inflammatory Myofibroblastic Neoplasm of the Urinary Bladder
has exact synonym: Inflammatory Myofibroblastic Tumor of Bladder
has exact synonym: Inflammatory Myofibroblastic Tumor of Urinary Bladder
has exact synonym: Inflammatory Myofibroblastic Tumor of the Bladder
has exact synonym: Inflammatory Myofibroblastic Tumor of the Urinary Bladder
has exact synonym: Urinary Bladder Inflammatory Myofibroblastic Neoplasm
has exact synonym: Urinary Bladder Inflammatory Myofibroblastic Tumor
in subset: oncotree slim

Axiom
annotated source: Bladder Inflammatory Myofibroblastic Tumor
annotated property: definition
annotated target: A multinodular intermediate fibroblastic neoplasm arising from the bladder. It is characterized by the presence of spindle-shaped fibroblasts and myofibroblasts, and a chronic inflammatory infiltrate composed of eosinophils, lymphocytes and plasma cells.
def-source: NCI

Axiom
annotated source: Bladder Inflammatory Myofibroblastic Tumor
annotated property: has exact synonym
annotated target: Bladder Inflammatory Myofibroblastic Neoplasm
term-group: SY
term-source: NCI

Axiom
annotated source: Bladder Inflammatory Myofibroblastic Tumor
annotated property: has exact synonym
annotated target: Bladder Inflammatory Myofibroblastic Tumor
term-group: PT
term-source: NCI

Axiom
annotated source: Bladder Inflammatory Myofibroblastic Tumor
annotated property: has exact synonym
annotated target: Inflammatory Myofibroblastic Neoplasm of Bladder
term-group: SY
term-source: NCI

Axiom
annotated source: Bladder Inflammatory Myofibroblastic Tumor
annotated property: has exact synonym
annotated target: Inflammatory Myofibroblastic Neoplasm of Urinary Bladder
term-group: SY
term-source: NCI

Axiom
annotated source: Bladder Inflammatory Myofibroblastic Tumor
annotated property: has exact synonym
annotated target: Inflammatory Myofibroblastic Neoplasm of the Bladder
term-group: SY
term-source: NCI

Axiom
annotated source: Bladder Inflammatory Myofibroblastic Tumor
annotated property: has exact synonym
annotated target: Inflammatory Myofibroblastic Neoplasm of the Urinary Bladder
term-group: SY
term-source: NCI

Axiom
annotated source: Bladder Inflammatory Myofibroblastic Tumor
annotated property: has exact synonym
annotated target: Inflammatory Myofibroblastic Tumor of Bladder
term-group: SY
term-source: NCI

Axiom
annotated source: Bladder Inflammatory Myofibroblastic Tumor
annotated property: has exact synonym
annotated target: Inflammatory Myofibroblastic Tumor of Urinary Bladder
term-group: SY
term-source: NCI

Axiom
annotated source: Bladder Inflammatory Myofibroblastic Tumor
annotated property: has exact synonym
annotated target: Inflammatory Myofibroblastic Tumor of the Bladder
term-group: SY
term-source: NCI

Axiom
annotated source: Bladder Inflammatory Myofibroblastic Tumor
annotated property: has exact synonym
annotated target: Inflammatory Myofibroblastic Tumor of the Urinary Bladder
term-group: SY
term-source: NCI

Axiom
annotated source: Bladder Inflammatory Myofibroblastic Tumor
annotated property: has exact synonym
annotated target: Urinary Bladder Inflammatory Myofibroblastic Neoplasm
term-group: SY
term-source: NCI

Axiom
annotated source: Bladder Inflammatory Myofibroblastic Tumor
annotated property: has exact synonym
annotated target: Urinary Bladder Inflammatory Myofibroblastic Tumor
term-group: SY
term-source: NCI

Carcinoma of the Collecting Ducts of Bellini
type: Class
definition: Also known as collecting duct carcinoma, this is a rare type of renal carcinoma. It arises from the collecting ducts of the renal medulla, and most authors suggest that this is an aggressive tumor.
Concept_In_Subset: NCIT C102905
Concept_In_Subset: NCIT C103084
Concept_In_Subset: NCIT C126659
code: C6194
Semantic_Type: Neoplastic Process
Preferred_Name: Carcinoma of the Collecting Ducts of Bellini
UMLS_CUI: C1266044
Contributing_Source: CTEP
ALT_DEFINITION: A rare type of kidney cancer that grows and spreads quickly. It begins in the duct of Bellini in the kidney.
ICD-O-3_Code: 8319/3
Neoplastic_Status: Malignant
Legacy_Concept_Name: Collecting_Duct_Carcinoma
has exact synonym: BDC
has exact synonym: Bellini Duct Carcinoma
has exact synonym: Bellini duct carcinoma
has exact synonym: Carcinoma of Collecting Ducts of Bellini
has exact synonym: Carcinoma of Kidney Collecting Duct
has exact synonym: Carcinoma of Renal Collecting Duct
has exact synonym: Carcinoma of the Collecting Ducts of Bellini
has exact synonym: Carcinoma of the Kidney Collecting Duct
has exact synonym: Carcinoma of the Renal Collecting Duct
has exact synonym: Collecting Duct Carcinoma
has exact synonym: Collecting Duct Renal Cell Carcinoma
has exact synonym: Collecting duct renal cancer
has exact synonym: Kidney Collecting Duct Carcinoma
has exact synonym: Renal Collecting Duct Carcinoma
in subset: oncotree slim

Axiom
annotated source: Carcinoma of the Collecting Ducts of Bellini
annotated property: definition
annotated target: Also known as collecting duct carcinoma, this is a rare type of renal carcinoma. It arises from the collecting ducts of the renal medulla, and most authors suggest that this is an aggressive tumor.
def-source: NCI

Axiom
annotated source: Carcinoma of the Collecting Ducts of Bellini
annotated property: ALT_DEFINITION
annotated target: A rare type of kidney cancer that grows and spreads quickly. It begins in the duct of Bellini in the kidney.
def-source: NCI-GLOSS

Axiom
annotated source: Carcinoma of the Collecting Ducts of Bellini
annotated property: has exact synonym
annotated target: BDC
term-group: PT
term-source: NCI-GLOSS
source-code: CDR0000584378

Axiom
annotated source: Carcinoma of the Collecting Ducts of Bellini
annotated property: has exact synonym
annotated target: Bellini Duct Carcinoma
term-group: SY
term-source: NCI

Axiom
annotated source: Carcinoma of the Collecting Ducts of Bellini
annotated property: has exact synonym
annotated target: Bellini duct carcinoma
term-group: PT
term-source: NCI-GLOSS
source-code: CDR0000044754

Axiom
annotated source: Carcinoma of the Collecting Ducts of Bellini
annotated property: has exact synonym
annotated target: Carcinoma of Collecting Ducts of Bellini
term-group: SY
term-source: NCI

Axiom
annotated source: Carcinoma of the Collecting Ducts of Bellini
annotated property: has exact synonym
annotated target: Carcinoma of Kidney Collecting Duct
term-group: SY
term-source: NCI

Axiom
annotated source: Carcinoma of the Collecting Ducts of Bellini
annotated property: has exact synonym
annotated target: Carcinoma of Renal Collecting Duct
term-group: SY
term-source: NCI

Axiom
annotated source: Carcinoma of the Collecting Ducts of Bellini
annotated property: has exact synonym
annotated target: Carcinoma of the Collecting Ducts of Bellini
term-group: PT
term-source: NCI

Axiom
annotated source: Carcinoma of the Collecting Ducts of Bellini
annotated property: has exact synonym
annotated target: Carcinoma of the Collecting Ducts of Bellini
term-group: SY
term-source: NCI
source-code: TCGA
subsource-name: caDSR

Axiom
annotated source: Carcinoma of the Collecting Ducts of Bellini
annotated property: has exact synonym
annotated target: Carcinoma of the Kidney Collecting Duct
term-group: SY
term-source: NCI

Axiom
annotated source: Carcinoma of the Collecting Ducts of Bellini
annotated property: has exact synonym
annotated target: Carcinoma of the Renal Collecting Duct
term-group: SY
term-source: NCI

Axiom
annotated source: Carcinoma of the Collecting Ducts of Bellini
annotated property: has exact synonym
annotated target: Collecting Duct Carcinoma
term-group: SY
term-source: NCI

Axiom
annotated source: Carcinoma of the Collecting Ducts of Bellini
annotated property: has exact synonym
annotated target: Collecting Duct Renal Cell Carcinoma
term-group: SY
term-source: NCI
subsource-name: caDSR

Axiom
annotated source: Carcinoma of the Collecting Ducts of Bellini
annotated property: has exact synonym
annotated target: Collecting duct renal cancer
term-group: PT
term-source: CTEP
source-code: 10066351
subsource-name: SDC

Axiom
annotated source: Carcinoma of the Collecting Ducts of Bellini
annotated property: has exact synonym
annotated target: Kidney Collecting Duct Carcinoma
term-group: SY
term-source: NCI

Axiom
annotated source: Carcinoma of the Collecting Ducts of Bellini
annotated property: has exact synonym
annotated target: Renal Collecting Duct Carcinoma
term-group: SY
term-source: NCI

Salivary Gland Clear Cell Carcinoma, Not Otherwise Specified
type: Class
subclass of: NCIT C9272
definition: A carcinoma that arises from the salivary glands, most often the minor salivary glands. It is characterized by the presence of a monomorphic population of malignant epithelial cells with clear cytoplasm and the absence of morphologic features that define other primary neoplasms of the salivary glands.
Concept_In_Subset: NCIT C126659
code: C62191
Semantic_Type: Neoplastic Process
Preferred_Name: Salivary Gland Clear Cell Carcinoma, Not Otherwise Specified
UMLS_CUI: C1882971
Neoplastic_Status: Malignant
Legacy_Concept_Name: Salivary_Gland_Clear_Cell_Carcinoma_Not_Otherwise_Specified
has exact synonym: Salivary Gland Clear Cell Carcinoma, NOS
has exact synonym: Salivary Gland Clear Cell Carcinoma, Not Otherwise Specified
in subset: oncotree slim

Axiom
annotated source: Salivary Gland Clear Cell Carcinoma, Not Otherwise Specified
annotated property: definition
annotated target: A carcinoma that arises from the salivary glands, most often the minor salivary glands. It is characterized by the presence of a monomorphic population of malignant epithelial cells with clear cytoplasm and the absence of morphologic features that define other primary neoplasms of the salivary glands.
def-source: NCI

Axiom
annotated source: Salivary Gland Clear Cell Carcinoma, Not Otherwise Specified
annotated property: has exact synonym
annotated target: Salivary Gland Clear Cell Carcinoma, NOS
term-group: SY
term-source: NCI

Axiom
annotated source: Salivary Gland Clear Cell Carcinoma, Not Otherwise Specified
annotated property: has exact synonym
annotated target: Salivary Gland Clear Cell Carcinoma, Not Otherwise Specified
term-group: PT
term-source: NCI

Endometrial Endometrioid Adenocarcinoma
type: Class
subclass of: Endometrioid Adenocarcinoma
definition: A primary endometrial adenocarcinoma composed of neoplastic cells that form complex glandular patterns associated with budding and branching of the neoplastic glands. The neoplastic glands resemble those of the normal endometrium and may or may not be associated with sheet-like proliferation of malignant cells. Endometrioid adenocarcinoma is the most commonly seen morphologic variant of endometrial adenocarcinoma.
Concept_In_Subset: NCIT C102905
Concept_In_Subset: NCIT C103103
Concept_In_Subset: NCIT C126659
code: C6287
Semantic_Type: Neoplastic Process
Preferred_Name: Endometrial Endometrioid Adenocarcinoma
UMLS_CUI: C1336905
Contributing_Source: CTEP
Neoplastic_Status: Malignant
Legacy_Concept_Name: Uterine_Corpus_Endometrioid_Adenocarcinoma
has exact synonym: Endometrial Endometrioid Adenocarcinoma
has exact synonym: Endometrioid Adenocarcinoma of Endometrium
has exact synonym: Endometrioid Adenocarcinoma of the Endometrium
has exact synonym: Endometrioid Carcinoma of Endometrium
has exact synonym: Endometrioid Carcinoma of the Endometrium
has exact synonym: Endometrioid endomet. adenocar.
has exact synonym: Endometrioid endometrial adenocarcinoma
has exact synonym: Uterine Corpus Endometrioid Adenocarcinoma
has exact synonym: Uterine Corpus Endometrioid Carcinoma
in subset: oncotree slim

Axiom
annotated source: Endometrial Endometrioid Adenocarcinoma
annotated property: definition
annotated target: A primary endometrial adenocarcinoma composed of neoplastic cells that form complex glandular patterns associated with budding and branching of the neoplastic glands. The neoplastic glands resemble those of the normal endometrium and may or may not be associated with sheet-like proliferation of malignant cells. Endometrioid adenocarcinoma is the most commonly seen morphologic variant of endometrial adenocarcinoma.
def-source: NCI

Axiom
annotated source: Endometrial Endometrioid Adenocarcinoma
annotated property: has exact synonym
annotated target: Endometrial Endometrioid Adenocarcinoma
term-group: PT
term-source: NCI

Axiom
annotated source: Endometrial Endometrioid Adenocarcinoma
annotated property: has exact synonym
annotated target: Endometrial Endometrioid Adenocarcinoma
term-group: SY
term-source: NCI
source-code: TCGA
subsource-name: caDSR

Axiom
annotated source: Endometrial Endometrioid Adenocarcinoma
annotated property: has exact synonym
annotated target: Endometrioid Adenocarcinoma of Endometrium
term-group: SY
term-source: NCI

Axiom
annotated source: Endometrial Endometrioid Adenocarcinoma
annotated property: has exact synonym
annotated target: Endometrioid Adenocarcinoma of the Endometrium
term-group: SY
term-source: NCI

Axiom
annotated source: Endometrial Endometrioid Adenocarcinoma
annotated property: has exact synonym
annotated target: Endometrioid Carcinoma of Endometrium
term-group: SY
term-source: NCI

Axiom
annotated source: Endometrial Endometrioid Adenocarcinoma
annotated property: has exact synonym
annotated target: Endometrioid Carcinoma of the Endometrium
term-group: SY
term-source: NCI

Axiom
annotated source: Endometrial Endometrioid Adenocarcinoma
annotated property: has exact synonym
annotated target: Endometrioid endomet. adenocar.
term-group: SY
term-source: CTEP
source-code: 10014735
subsource-name: SDC

Axiom
annotated source: Endometrial Endometrioid Adenocarcinoma
annotated property: has exact synonym
annotated target: Endometrioid endometrial adenocarcinoma
term-group: PT
term-source: CTEP
source-code: 10014735
subsource-name: SDC

Axiom
annotated source: Endometrial Endometrioid Adenocarcinoma
annotated property: has exact synonym
annotated target: Uterine Corpus Endometrioid Adenocarcinoma
term-group: SY
term-source: NCI

Axiom
annotated source: Endometrial Endometrioid Adenocarcinoma
annotated property: has exact synonym
annotated target: Uterine Corpus Endometrioid Carcinoma
term-group: SY
term-source: NCI

Uterine Corpus Adenosarcoma
type: Class
definition: A primary polypoid malignant neoplasm of the uterine corpus characterized by the presence of a sarcomatous mesenchymal component and a benign epithelial component. Patients usually present with abnormal vaginal bleeding. It is considered a low grade malignant neoplasm and may recur following resection.
Concept_In_Subset: NCIT C126659
code: C6336
Semantic_Type: Neoplastic Process
Preferred_Name: Uterine Corpus Adenosarcoma
UMLS_CUI: C1336917
Neoplastic_Status: Malignant
Legacy_Concept_Name: Uterine_Corpus_Mullerian_Adenosarcoma
has exact synonym: Adenosarcoma of Body of Uterus
has exact synonym: Adenosarcoma of Uterine Body
has exact synonym: Adenosarcoma of Uterine Corpus
has exact synonym: Adenosarcoma of the Body of Uterus
has exact synonym: Adenosarcoma of the Uterine Body
has exact synonym: Adenosarcoma of the Uterine Corpus
has exact synonym: Body of Uterus Adenosarcoma
has exact synonym: Uterine Body Adenosarcoma
has exact synonym: Uterine Corpus Adenosarcoma
has exact synonym: Uterine Corpus Mullerian Adenosarcoma
has exact synonym: Uterine Corpus Müllerian Adenosarcoma
in subset: oncotree slim

Axiom
annotated source: Uterine Corpus Adenosarcoma
annotated property: definition
annotated target: A primary polypoid malignant neoplasm of the uterine corpus characterized by the presence of a sarcomatous mesenchymal component and a benign epithelial component. Patients usually present with abnormal vaginal bleeding. It is considered a low grade malignant neoplasm and may recur following resection.
def-source: NCI

Axiom
annotated source: Uterine Corpus Adenosarcoma
annotated property: has exact synonym
annotated target: Adenosarcoma of Body of Uterus
term-group: SY
term-source: NCI

Axiom
annotated source: Uterine Corpus Adenosarcoma
annotated property: has exact synonym
annotated target: Adenosarcoma of Uterine Body
term-group: SY
term-source: NCI

Axiom
annotated source: Uterine Corpus Adenosarcoma
annotated property: has exact synonym
annotated target: Adenosarcoma of Uterine Corpus
term-group: SY
term-source: NCI

Axiom
annotated source: Uterine Corpus Adenosarcoma
annotated property: has exact synonym
annotated target: Adenosarcoma of the Body of Uterus
term-group: SY
term-source: NCI

Axiom
annotated source: Uterine Corpus Adenosarcoma
annotated property: has exact synonym
annotated target: Adenosarcoma of the Uterine Body
term-group: SY
term-source: NCI

Axiom
annotated source: Uterine Corpus Adenosarcoma
annotated property: has exact synonym
annotated target: Adenosarcoma of the Uterine Corpus
term-group: SY
term-source: NCI

Axiom
annotated source: Uterine Corpus Adenosarcoma
annotated property: has exact synonym
annotated target: Body of Uterus Adenosarcoma
term-group: SY
term-source: NCI

Axiom
annotated source: Uterine Corpus Adenosarcoma
annotated property: has exact synonym
annotated target: Uterine Body Adenosarcoma
term-group: SY
term-source: NCI

Axiom
annotated source: Uterine Corpus Adenosarcoma
annotated property: has exact synonym
annotated target: Uterine Corpus Adenosarcoma
term-group: PT
term-source: NCI

Axiom
annotated source: Uterine Corpus Adenosarcoma
annotated property: has exact synonym
annotated target: Uterine Corpus Mullerian Adenosarcoma
term-group: SY
term-source: NCI

Axiom
annotated source: Uterine Corpus Adenosarcoma
annotated property: has exact synonym
annotated target: Uterine Corpus Müllerian Adenosarcoma
term-group: SY
term-source: NCI

Uterine Corpus Sarcoma
type: Class
definition: A malignant mesenchymal neoplasm arising from the wall of the uterine corpus (uterine body). The most representative examples are leiomyosarcoma and endometrial stromal sarcoma.
Concept_In_Subset: NCIT C116977
code: C6339
Semantic_Type: Neoplastic Process
Display_Name: Uterine Sarcoma, Corpus
Preferred_Name: Uterine Corpus Sarcoma
UMLS_CUI: C0338113
Contributing_Source: CTRP
ALT_DEFINITION: A rare type of uterine cancer that forms in muscle or other tissues of the uterus (the small, hollow, pear-shaped organ in a woman's pelvis in which a fetus develops). It usually occurs after menopause. The two main types are leiomyosarcoma (cancer that begins in smooth muscle cells) and endometrial stromal sarcoma (cancer that begins in connective tissue cells).
Neoplastic_Status: Malignant
Legacy_Concept_Name: Uterine_Corpus_Sarcoma
has exact synonym: Body of Uterus Sarcoma
has exact synonym: Corpus Uteri Sarcoma
has exact synonym: Sarcoma of Body of Uterus
has exact synonym: Sarcoma of Corpus Uteri
has exact synonym: Sarcoma of Uterine Body
has exact synonym: Sarcoma of Uterine Corpus
has exact synonym: Sarcoma of Uterus
has exact synonym: Sarcoma of the Body of Uterus
has exact synonym: Sarcoma of the Corpus Uteri
has exact synonym: Sarcoma of the Uterine Body
has exact synonym: Sarcoma of the Uterine Corpus
has exact synonym: Sarcoma of the Uterus
has exact synonym: Uterine Body Sarcoma
has exact synonym: Uterine Corpus Sarcoma
has exact synonym: Uterine Sarcoma
has exact synonym: Uterus Sarcoma
has exact synonym: uterine sarcoma
in subset: oncotree slim

Axiom
annotated source: Uterine Corpus Sarcoma
annotated property: definition
annotated target: A malignant mesenchymal neoplasm arising from the wall of the uterine corpus (uterine body). The most representative examples are leiomyosarcoma and endometrial stromal sarcoma.
def-source: NCI

Axiom
annotated source: Uterine Corpus Sarcoma
annotated property: ALT_DEFINITION
annotated target: A rare type of uterine cancer that forms in muscle or other tissues of the uterus (the small, hollow, pear-shaped organ in a woman's pelvis in which a fetus develops). It usually occurs after menopause. The two main types are leiomyosarcoma (cancer that begins in smooth muscle cells) and endometrial stromal sarcoma (cancer that begins in connective tissue cells).
def-source: NCI-GLOSS

Axiom
annotated source: Uterine Corpus Sarcoma
annotated property: has exact synonym
annotated target: Body of Uterus Sarcoma
term-group: SY
term-source: NCI

Axiom
annotated source: Uterine Corpus Sarcoma
annotated property: has exact synonym
annotated target: Corpus Uteri Sarcoma
term-group: SY
term-source: NCI

Axiom
annotated source: Uterine Corpus Sarcoma
annotated property: has exact synonym
annotated target: Sarcoma of Body of Uterus
term-group: SY
term-source: NCI

Axiom
annotated source: Uterine Corpus Sarcoma
annotated property: has exact synonym
annotated target: Sarcoma of Corpus Uteri
term-group: SY
term-source: NCI

Axiom
annotated source: Uterine Corpus Sarcoma
annotated property: has exact synonym
annotated target: Sarcoma of Uterine Body
term-group: SY
term-source: NCI

Axiom
annotated source: Uterine Corpus Sarcoma
annotated property: has exact synonym
annotated target: Sarcoma of Uterine Corpus
term-group: SY
term-source: NCI

Axiom
annotated source: Uterine Corpus Sarcoma
annotated property: has exact synonym
annotated target: Sarcoma of Uterus
term-group: SY
term-source: NCI

Axiom
annotated source: Uterine Corpus Sarcoma
annotated property: has exact synonym
annotated target: Sarcoma of the Body of Uterus
term-group: SY
term-source: NCI

Axiom
annotated source: Uterine Corpus Sarcoma
annotated property: has exact synonym
annotated target: Sarcoma of the Corpus Uteri
term-group: SY
term-source: NCI

Axiom
annotated source: Uterine Corpus Sarcoma
annotated property: has exact synonym
annotated target: Sarcoma of the Uterine Body
term-group: SY
term-source: NCI

Axiom
annotated source: Uterine Corpus Sarcoma
annotated property: has exact synonym
annotated target: Sarcoma of the Uterine Corpus
term-group: SY
term-source: NCI

Axiom
annotated source: Uterine Corpus Sarcoma
annotated property: has exact synonym
annotated target: Sarcoma of the Uterus
term-group: SY
term-source: NCI

Axiom
annotated source: Uterine Corpus Sarcoma
annotated property: has exact synonym
annotated target: Uterine Body Sarcoma
term-group: SY
term-source: NCI

Axiom
annotated source: Uterine Corpus Sarcoma
annotated property: has exact synonym
annotated target: Uterine Corpus Sarcoma
term-group: PT
term-source: NCI

Axiom
annotated source: Uterine Corpus Sarcoma
annotated property: has exact synonym
annotated target: Uterine Sarcoma
term-group: SY
term-source: NCI

Axiom
annotated source: Uterine Corpus Sarcoma
annotated property: has exact synonym
annotated target: Uterus Sarcoma
term-group: SY
term-source: NCI

Axiom
annotated source: Uterine Corpus Sarcoma
annotated property: has exact synonym
annotated target: uterine sarcoma
term-group: PT
term-source: NCI-GLOSS
source-code: CDR0000445097

Uterine Corpus Leiomyosarcoma
type: Class
subclass of: Uterine Corpus Smooth Muscle Neoplasm
subclass of: Uterine Corpus Sarcoma
definition: An aggressive malignant smooth muscle neoplasm, arising from the uterine corpus. It is characterized by a proliferation of neoplastic spindle cells.
Concept_In_Subset: NCIT C102905
Concept_In_Subset: NCIT C103103
Concept_In_Subset: NCIT C116977
Concept_In_Subset: NCIT C126659
code: C6340
Semantic_Type: Neoplastic Process
Display_Name: Uterine Corpus Leiomyosarcoma
Preferred_Name: Uterine Corpus Leiomyosarcoma
UMLS_CUI: C0280631
Contributing_Source: CTEP
Contributing_Source: CTRP
Neoplastic_Status: Malignant
Legacy_Concept_Name: Uterine_Corpus_Leiomyosarcoma
has exact synonym: Body of Uterus Leiomyosarcoma
has exact synonym: Corpus Uteri Leiomyosarcoma
has exact synonym: Leiomyosarcoma - uterus
has exact synonym: Leiomyosarcoma of Body of Uterus
has exact synonym: Leiomyosarcoma of Corpus Uteri
has exact synonym: Leiomyosarcoma of Uterine Body
has exact synonym: Leiomyosarcoma of Uterine Corpus
has exact synonym: Leiomyosarcoma of Uterus
has exact synonym: Leiomyosarcoma of the Body of Uterus
has exact synonym: Leiomyosarcoma of the Corpus Uteri
has exact synonym: Leiomyosarcoma of the Uterine Body
has exact synonym: Leiomyosarcoma of the Uterine Corpus
has exact synonym: Leiomyosarcoma of the Uterus
has exact synonym: Leiomyosarcoma of the uterus
has exact synonym: Uterine Body Leiomyosarcoma
has exact synonym: Uterine Corpus Leiomyosarcoma
in subset: oncotree slim

Axiom
annotated source: Uterine Corpus Leiomyosarcoma
annotated property: definition
annotated target: An aggressive malignant smooth muscle neoplasm, arising from the uterine corpus. It is characterized by a proliferation of neoplastic spindle cells.
def-source: NCI

Axiom
annotated source: Uterine Corpus Leiomyosarcoma
annotated property: has exact synonym
annotated target: Body of Uterus Leiomyosarcoma
term-group: SY
term-source: NCI

Axiom
annotated source: Uterine Corpus Leiomyosarcoma
annotated property: has exact synonym
annotated target: Corpus Uteri Leiomyosarcoma
term-group: SY
term-source: NCI

Axiom
annotated source: Uterine Corpus Leiomyosarcoma
annotated property: has exact synonym
annotated target: Leiomyosarcoma - uterus
term-group: SY
term-source: CTEP
source-code: 10046799
subsource-name: SDC

Axiom
annotated source: Uterine Corpus Leiomyosarcoma
annotated property: has exact synonym
annotated target: Leiomyosarcoma of Body of Uterus
term-group: SY
term-source: NCI

Axiom
annotated source: Uterine Corpus Leiomyosarcoma
annotated property: has exact synonym
annotated target: Leiomyosarcoma of Corpus Uteri
term-group: SY
term-source: NCI

Axiom
annotated source: Uterine Corpus Leiomyosarcoma
annotated property: has exact synonym
annotated target: Leiomyosarcoma of Uterine Body
term-group: SY
term-source: NCI

Axiom
annotated source: Uterine Corpus Leiomyosarcoma
annotated property: has exact synonym
annotated target: Leiomyosarcoma of Uterine Corpus
term-group: SY
term-source: NCI

Axiom
annotated source: Uterine Corpus Leiomyosarcoma
annotated property: has exact synonym
annotated target: Leiomyosarcoma of Uterus
term-group: SY
term-source: NCI

Axiom
annotated source: Uterine Corpus Leiomyosarcoma
annotated property: has exact synonym
annotated target: Leiomyosarcoma of the Body of Uterus
term-group: SY
term-source: NCI

Axiom
annotated source: Uterine Corpus Leiomyosarcoma
annotated property: has exact synonym
annotated target: Leiomyosarcoma of the Corpus Uteri
term-group: SY
term-source: NCI

Axiom
annotated source: Uterine Corpus Leiomyosarcoma
annotated property: has exact synonym
annotated target: Leiomyosarcoma of the Uterine Body
term-group: SY
term-source: NCI

Axiom
annotated source: Uterine Corpus Leiomyosarcoma
annotated property: has exact synonym
annotated target: Leiomyosarcoma of the Uterine Corpus
term-group: SY
term-source: NCI

Axiom
annotated source: Uterine Corpus Leiomyosarcoma
annotated property: has exact synonym
annotated target: Leiomyosarcoma of the Uterus
term-group: SY
term-source: NCI

Axiom
annotated source: Uterine Corpus Leiomyosarcoma
annotated property: has exact synonym
annotated target: Leiomyosarcoma of the uterus
term-group: PT
term-source: CTEP
source-code: 10046799
subsource-name: SDC

Axiom
annotated source: Uterine Corpus Leiomyosarcoma
annotated property: has exact synonym
annotated target: Uterine Body Leiomyosarcoma
term-group: SY
term-source: NCI

Axiom
annotated source: Uterine Corpus Leiomyosarcoma
annotated property: has exact synonym
annotated target: Uterine Corpus Leiomyosarcoma
term-group: PT
term-source: NCI

Testicular Embryonal Carcinoma
type: Class
subclass of: Embryonal Carcinoma
definition: A malignant germ cell neoplasm arising from the testis. It is composed of primitive epithelial cells arranged in solid, papillary, and glandular configurations. Most patients present with a testicular mass, which may be associated with pain. More than half of the patients have metastatic disease at diagnosis. The form of treatment following radical orchiectomy is stage dependent.
Concept_In_Subset: NCIT C116977
code: C6341
Semantic_Type: Neoplastic Process
Display_Name: Testicular Embryonal Carcinoma
Preferred_Name: Testicular Embryonal Carcinoma
UMLS_CUI: C0238448
Contributing_Source: CTRP
Neoplastic_Status: Malignant
Legacy_Concept_Name: Testicular_Embryonal_Carcinoma
has exact synonym: Embryonal Carcinoma of Testis
has exact synonym: Embryonal Carcinoma of the Testis
has exact synonym: Testicular Embryonal Carcinoma
in subset: oncotree slim

Axiom
annotated source: Testicular Embryonal Carcinoma
annotated property: definition
annotated target: A malignant germ cell neoplasm arising from the testis. It is composed of primitive epithelial cells arranged in solid, papillary, and glandular configurations. Most patients present with a testicular mass, which may be associated with pain. More than half of the patients have metastatic disease at diagnosis. The form of treatment following radical orchiectomy is stage dependent.
def-source: NCI

Axiom
annotated source: Testicular Embryonal Carcinoma
annotated property: has exact synonym
annotated target: Embryonal Carcinoma of Testis
term-group: SY
term-source: NCI

Axiom
annotated source: Testicular Embryonal Carcinoma
annotated property: has exact synonym
annotated target: Embryonal Carcinoma of the Testis
term-group: SY
term-source: NCI

Axiom
annotated source: Testicular Embryonal Carcinoma
annotated property: has exact synonym
annotated target: Testicular Embryonal Carcinoma
term-group: DN
term-source: CTRP

Axiom
annotated source: Testicular Embryonal Carcinoma
annotated property: has exact synonym
annotated target: Testicular Embryonal Carcinoma
term-group: PT
term-source: NCI

Axiom
annotated source: Testicular Embryonal Carcinoma
annotated property: has exact synonym
annotated target: Testicular Embryonal Carcinoma
term-group: SY
term-source: NCI
subsource-name: caDSR

Cervical Clear Cell Adenocarcinoma
type: Class
subclass of: Cervical Adenocarcinoma
definition: A rare morphologic variant of cervical adenocarcinoma composed of clear and hobnail cells. It is associated with in utero exposure to diethylstilbestrol (DES).
code: C6344
Semantic_Type: Neoplastic Process
Preferred_Name: Cervical Clear Cell Adenocarcinoma
UMLS_CUI: C1332912
Neoplastic_Status: Malignant
Legacy_Concept_Name: Cervical_Clear_Cell_Carcinoma
has exact synonym: Cervical Clear Cell Adenocarcinoma
has exact synonym: Cervical Clear Cell Carcinoma
has exact synonym: Cervix Clear Cell Adenocarcinoma
has exact synonym: Cervix Clear Cell Carcinoma
has exact synonym: Cervix Uteri Clear Cell Adenocarcinoma
has exact synonym: Cervix Uteri Clear Cell Carcinoma
has exact synonym: Clear Cell Adenocarcinoma of Cervix
has exact synonym: Clear Cell Adenocarcinoma of Cervix Uteri
has exact synonym: Clear Cell Adenocarcinoma of Uterine Cervix
has exact synonym: Clear Cell Adenocarcinoma of the Cervix
has exact synonym: Clear Cell Adenocarcinoma of the Cervix Uteri
has exact synonym: Clear Cell Adenocarcinoma of the Uterine Cervix
has exact synonym: Clear Cell Carcinoma of Cervix
has exact synonym: Clear Cell Carcinoma of Cervix Uteri
has exact synonym: Clear Cell Carcinoma of Uterine Cervix
has exact synonym: Clear Cell Carcinoma of the Cervix
has exact synonym: Clear Cell Carcinoma of the Cervix Uteri
has exact synonym: Clear Cell Carcinoma of the Uterine Cervix
has exact synonym: Uterine Cervix Clear Cell Adenocarcinoma
has exact synonym: Uterine Cervix Clear Cell Carcinoma
in subset: oncotree slim

Axiom
annotated source: Cervical Clear Cell Adenocarcinoma
annotated property: definition
annotated target: A rare morphologic variant of cervical adenocarcinoma composed of clear and hobnail cells. It is associated with in utero exposure to diethylstilbestrol (DES).
def-source: NCI

Axiom
annotated source: Cervical Clear Cell Adenocarcinoma
annotated property: has exact synonym
annotated target: Cervical Clear Cell Adenocarcinoma
term-group: PT
term-source: NCI

Axiom
annotated source: Cervical Clear Cell Adenocarcinoma
annotated property: has exact synonym
annotated target: Cervical Clear Cell Carcinoma
term-group: SY
term-source: NCI

Axiom
annotated source: Cervical Clear Cell Adenocarcinoma
annotated property: has exact synonym
annotated target: Cervix Clear Cell Adenocarcinoma
term-group: SY
term-source: NCI

Axiom
annotated source: Cervical Clear Cell Adenocarcinoma
annotated property: has exact synonym
annotated target: Cervix Clear Cell Carcinoma
term-group: SY
term-source: NCI

Axiom
annotated source: Cervical Clear Cell Adenocarcinoma
annotated property: has exact synonym
annotated target: Cervix Uteri Clear Cell Adenocarcinoma
term-group: SY
term-source: NCI

Axiom
annotated source: Cervical Clear Cell Adenocarcinoma
annotated property: has exact synonym
annotated target: Cervix Uteri Clear Cell Carcinoma
term-group: SY
term-source: NCI

Axiom
annotated source: Cervical Clear Cell Adenocarcinoma
annotated property: has exact synonym
annotated target: Clear Cell Adenocarcinoma of Cervix
term-group: SY
term-source: NCI

Axiom
annotated source: Cervical Clear Cell Adenocarcinoma
annotated property: has exact synonym
annotated target: Clear Cell Adenocarcinoma of Cervix Uteri
term-group: SY
term-source: NCI

Axiom
annotated source: Cervical Clear Cell Adenocarcinoma
annotated property: has exact synonym
annotated target: Clear Cell Adenocarcinoma of Uterine Cervix
term-group: SY
term-source: NCI

Axiom
annotated source: Cervical Clear Cell Adenocarcinoma
annotated property: has exact synonym
annotated target: Clear Cell Adenocarcinoma of the Cervix
term-group: SY
term-source: NCI

Axiom
annotated source: Cervical Clear Cell Adenocarcinoma
annotated property: has exact synonym
annotated target: Clear Cell Adenocarcinoma of the Cervix Uteri
term-group: SY
term-source: NCI

Axiom
annotated source: Cervical Clear Cell Adenocarcinoma
annotated property: has exact synonym
annotated target: Clear Cell Adenocarcinoma of the Uterine Cervix
term-group: SY
term-source: NCI

Axiom
annotated source: Cervical Clear Cell Adenocarcinoma
annotated property: has exact synonym
annotated target: Clear Cell Carcinoma of Cervix
term-group: SY
term-source: NCI

Axiom
annotated source: Cervical Clear Cell Adenocarcinoma
annotated property: has exact synonym
annotated target: Clear Cell Carcinoma of Cervix Uteri
term-group: SY
term-source: NCI

Axiom
annotated source: Cervical Clear Cell Adenocarcinoma
annotated property: has exact synonym
annotated target: Clear Cell Carcinoma of Uterine Cervix
term-group: SY
term-source: NCI

Axiom
annotated source: Cervical Clear Cell Adenocarcinoma
annotated property: has exact synonym
annotated target: Clear Cell Carcinoma of the Cervix
term-group: SY
term-source: NCI

Axiom
annotated source: Cervical Clear Cell Adenocarcinoma
annotated property: has exact synonym
annotated target: Clear Cell Carcinoma of the Cervix Uteri
term-group: SY
term-source: NCI

Axiom
annotated source: Cervical Clear Cell Adenocarcinoma
annotated property: has exact synonym
annotated target: Clear Cell Carcinoma of the Uterine Cervix
term-group: SY
term-source: NCI

Axiom
annotated source: Cervical Clear Cell Adenocarcinoma
annotated property: has exact synonym
annotated target: Uterine Cervix Clear Cell Adenocarcinoma
term-group: SY
term-source: NCI

Axiom
annotated source: Cervical Clear Cell Adenocarcinoma
annotated property: has exact synonym
annotated target: Uterine Cervix Clear Cell Carcinoma
term-group: SY
term-source: NCI

Cervical Undifferentiated Carcinoma
type: Class
definition: A carcinoma that arises from the cervix and is characterized by the lack of specific cellular differentiation.
code: C6345
Semantic_Type: Neoplastic Process
Preferred_Name: Cervical Undifferentiated Carcinoma
UMLS_CUI: C0850327
Neoplastic_Status: Malignant
Legacy_Concept_Name: Undifferentiated_Cervical_Carcinoma
has exact synonym: Cervical Undifferentiated Carcinoma
has exact synonym: Undifferentiated Carcinoma of Cervix
has exact synonym: Undifferentiated Carcinoma of Cervix Uteri
has exact synonym: Undifferentiated Carcinoma of Uterine Cervix
has exact synonym: Undifferentiated Carcinoma of the Cervix
has exact synonym: Undifferentiated Carcinoma of the Cervix Uteri
has exact synonym: Undifferentiated Carcinoma of the Uterine Cervix
has exact synonym: Undifferentiated Cervical Cancer
has exact synonym: Undifferentiated Cervix Carcinoma
has exact synonym: Undifferentiated Cervix Uteri Carcinoma
has exact synonym: Undifferentiated Uterine Cervix Carcinoma
in subset: oncotree slim

Axiom
annotated source: Cervical Undifferentiated Carcinoma
annotated property: definition
annotated target: A carcinoma that arises from the cervix and is characterized by the lack of specific cellular differentiation.
def-source: NCI

Axiom
annotated source: Cervical Undifferentiated Carcinoma
annotated property: has exact synonym
annotated target: Cervical Undifferentiated Carcinoma
term-group: PT
term-source: NCI

Axiom
annotated source: Cervical Undifferentiated Carcinoma
annotated property: has exact synonym
annotated target: Undifferentiated Carcinoma of Cervix
term-group: SY
term-source: NCI

Axiom
annotated source: Cervical Undifferentiated Carcinoma
annotated property: has exact synonym
annotated target: Undifferentiated Carcinoma of Cervix Uteri
term-group: SY
term-source: NCI

Axiom
annotated source: Cervical Undifferentiated Carcinoma
annotated property: has exact synonym
annotated target: Undifferentiated Carcinoma of Uterine Cervix
term-group: SY
term-source: NCI

Axiom
annotated source: Cervical Undifferentiated Carcinoma
annotated property: has exact synonym
annotated target: Undifferentiated Carcinoma of the Cervix
term-group: SY
term-source: NCI

Axiom
annotated source: Cervical Undifferentiated Carcinoma
annotated property: has exact synonym
annotated target: Undifferentiated Carcinoma of the Cervix Uteri
term-group: SY
term-source: NCI

Axiom
annotated source: Cervical Undifferentiated Carcinoma
annotated property: has exact synonym
annotated target: Undifferentiated Carcinoma of the Uterine Cervix
term-group: SY
term-source: NCI

Axiom
annotated source: Cervical Undifferentiated Carcinoma
annotated property: has exact synonym
annotated target: Undifferentiated Cervical Cancer
term-group: DN
term-source: CTRP

Axiom
annotated source: Cervical Undifferentiated Carcinoma
annotated property: has exact synonym
annotated target: Undifferentiated Cervix Carcinoma
term-group: SY
term-source: NCI

Axiom
annotated source: Cervical Undifferentiated Carcinoma
annotated property: has exact synonym
annotated target: Undifferentiated Cervix Uteri Carcinoma
term-group: SY
term-source: NCI

Axiom
annotated source: Cervical Undifferentiated Carcinoma
annotated property: has exact synonym
annotated target: Undifferentiated Uterine Cervix Carcinoma
term-group: SY
term-source: NCI

Cervical Adenoid Cystic Carcinoma
type: Class
subclass of: Adenoid Cystic Carcinoma
definition: A rare carcinoma that arises from the cervix. It is characterized by the presence of cystic spaces surrounded by palisaded epithelial cells. The cystic spaces contain eosinophilic hyaline material or mucin. Nuclear pleomorphism, necrotic changes, and a high mitotic rate are also present.
code: C6346
Semantic_Type: Neoplastic Process
Preferred_Name: Cervical Adenoid Cystic Carcinoma
UMLS_CUI: C1332911
Neoplastic_Status: Malignant
Legacy_Concept_Name: Cervical_Adenoid_Cystic_Carcinoma
has exact synonym: Adenoid Cystic Carcinoma of Cervix
has exact synonym: Adenoid Cystic Carcinoma of Cervix Uteri
has exact synonym: Adenoid Cystic Carcinoma of Uterine Cervix
has exact synonym: Adenoid Cystic Carcinoma of the Cervix
has exact synonym: Adenoid Cystic Carcinoma of the Cervix Uteri
has exact synonym: Adenoid Cystic Carcinoma of the Uterine Cervix
has exact synonym: Cervical Adenoid Cystic Cancer
has exact synonym: Cervical Adenoid Cystic Carcinoma
has exact synonym: Cervix Adenoid Cystic Carcinoma
has exact synonym: Cervix Uteri Adenoid Cystic Carcinoma
has exact synonym: Uterine Cervix Adenoid Cystic Carcinoma
in subset: oncotree slim

Axiom
annotated source: Cervical Adenoid Cystic Carcinoma
annotated property: definition
annotated target: A rare carcinoma that arises from the cervix. It is characterized by the presence of cystic spaces surrounded by palisaded epithelial cells. The cystic spaces contain eosinophilic hyaline material or mucin. Nuclear pleomorphism, necrotic changes, and a high mitotic rate are also present.
def-source: NCI

Axiom
annotated source: Cervical Adenoid Cystic Carcinoma
annotated property: has exact synonym
annotated target: Adenoid Cystic Carcinoma of Cervix
term-group: SY
term-source: NCI

Axiom
annotated source: Cervical Adenoid Cystic Carcinoma
annotated property: has exact synonym
annotated target: Adenoid Cystic Carcinoma of Cervix Uteri
term-group: SY
term-source: NCI

Axiom
annotated source: Cervical Adenoid Cystic Carcinoma
annotated property: has exact synonym
annotated target: Adenoid Cystic Carcinoma of Uterine Cervix
term-group: SY
term-source: NCI

Axiom
annotated source: Cervical Adenoid Cystic Carcinoma
annotated property: has exact synonym
annotated target: Adenoid Cystic Carcinoma of the Cervix
term-group: SY
term-source: NCI

Axiom
annotated source: Cervical Adenoid Cystic Carcinoma
annotated property: has exact synonym
annotated target: Adenoid Cystic Carcinoma of the Cervix Uteri
term-group: SY
term-source: NCI

Axiom
annotated source: Cervical Adenoid Cystic Carcinoma
annotated property: has exact synonym
annotated target: Adenoid Cystic Carcinoma of the Uterine Cervix
term-group: SY
term-source: NCI

Axiom
annotated source: Cervical Adenoid Cystic Carcinoma
annotated property: has exact synonym
annotated target: Cervical Adenoid Cystic Cancer
term-group: DN
term-source: CTRP

Axiom
annotated source: Cervical Adenoid Cystic Carcinoma
annotated property: has exact synonym
annotated target: Cervical Adenoid Cystic Carcinoma
term-group: PT
term-source: NCI

Axiom
annotated source: Cervical Adenoid Cystic Carcinoma
annotated property: has exact synonym
annotated target: Cervix Adenoid Cystic Carcinoma
term-group: SY
term-source: NCI

Axiom
annotated source: Cervical Adenoid Cystic Carcinoma
annotated property: has exact synonym
annotated target: Cervix Uteri Adenoid Cystic Carcinoma
term-group: SY
term-source: NCI

Axiom
annotated source: Cervical Adenoid Cystic Carcinoma
annotated property: has exact synonym
annotated target: Uterine Cervix Adenoid Cystic Carcinoma
term-group: SY
term-source: NCI

Vaginal Yolk Sac Tumor
type: Class
subclass of: Yolk Sac Tumor
definition: A rare yolk sac tumor that arises from the vagina.Patients present with abnormal vaginal bleeding or bloody discharge.
code: C6379
Semantic_Type: Neoplastic Process
Preferred_Name: Vaginal Yolk Sac Tumor
UMLS_CUI: C1336945
Neoplastic_Status: Malignant
Legacy_Concept_Name: Vaginal_Yolk_Sac_Tumor
has exact synonym: Vaginal Endodermal Sinus Neoplasm
has exact synonym: Vaginal Endodermal Sinus Tumor
has exact synonym: Vaginal Yolk Sac Neoplasm
has exact synonym: Vaginal Yolk Sac Tumor
in subset: oncotree slim

Axiom
annotated source: Vaginal Yolk Sac Tumor
annotated property: definition
annotated target: A rare yolk sac tumor that arises from the vagina.Patients present with abnormal vaginal bleeding or bloody discharge.
def-source: NCI

Axiom
annotated source: Vaginal Yolk Sac Tumor
annotated property: has exact synonym
annotated target: Vaginal Endodermal Sinus Neoplasm
term-group: SY
term-source: NCI

Axiom
annotated source: Vaginal Yolk Sac Tumor
annotated property: has exact synonym
annotated target: Vaginal Endodermal Sinus Tumor
term-group: SY
term-source: NCI

Axiom
annotated source: Vaginal Yolk Sac Tumor
annotated property: has exact synonym
annotated target: Vaginal Yolk Sac Neoplasm
term-group: SY
term-source: NCI

Axiom
annotated source: Vaginal Yolk Sac Tumor
annotated property: has exact synonym
annotated target: Vaginal Yolk Sac Tumor
term-group: PT
term-source: NCI

Thymus Epithelial Neoplasm
type: Class
definition: An epithelial neoplasm that affects the thymus gland. This category includes thymomas and carcinomas.
Concept_In_Subset: NCIT C116977
code: C6450
Semantic_Type: Neoplastic Process
Display_Name: Thymus Epithelial Neoplasm
Preferred_Name: Thymus Epithelial Neoplasm
UMLS_CUI: C1266101
Contributing_Source: CTRP
Neoplastic_Status: Undetermined
Legacy_Concept_Name: Thymus_Epithelial_Neoplasm
has exact synonym: Epithelial Neoplasm of Thymus
has exact synonym: Epithelial Neoplasm of the Thymus
has exact synonym: Epithelial Tumor of Thymus
has exact synonym: Epithelial Tumor of the Thymus
has exact synonym: Thymic Epithelial Tumor
has exact synonym: Thymic Epithelium Neoplasm
has exact synonym: Thymus Epithelial Neoplasm
has exact synonym: Thymus Epithelial Tumor
in subset: oncotree slim

Axiom
annotated source: Thymus Epithelial Neoplasm
annotated property: definition
annotated target: An epithelial neoplasm that affects the thymus gland. This category includes thymomas and carcinomas.
def-source: NCI

Axiom
annotated source: Thymus Epithelial Neoplasm
annotated property: has exact synonym
annotated target: Epithelial Neoplasm of Thymus
term-group: SY
term-source: NCI

Axiom
annotated source: Thymus Epithelial Neoplasm
annotated property: has exact synonym
annotated target: Epithelial Neoplasm of the Thymus
term-group: SY
term-source: NCI

Axiom
annotated source: Thymus Epithelial Neoplasm
annotated property: has exact synonym
annotated target: Epithelial Tumor of Thymus
term-group: SY
term-source: NCI

Axiom
annotated source: Thymus Epithelial Neoplasm
annotated property: has exact synonym
annotated target: Epithelial Tumor of the Thymus
term-group: SY
term-source: NCI

Axiom
annotated source: Thymus Epithelial Neoplasm
annotated property: has exact synonym
annotated target: Thymic Epithelial Tumor
term-group: SY
term-source: NCI

Axiom
annotated source: Thymus Epithelial Neoplasm
annotated property: has exact synonym
annotated target: Thymic Epithelium Neoplasm
term-group: SY
term-source: NCI

Axiom
annotated source: Thymus Epithelial Neoplasm
annotated property: has exact synonym
annotated target: Thymus Epithelial Neoplasm
term-group: PT
term-source: NCI

Axiom
annotated source: Thymus Epithelial Neoplasm
annotated property: has exact synonym
annotated target: Thymus Epithelial Tumor
term-group: SY
term-source: NCI

Low Grade Central Osteosarcoma
type: Class
definition: A low grade osteosarcoma arising from the medullary portion of the bone. It affects the long bones and is characterized by the presence of fibroblastic stroma and osteoid production. Pain and swelling are the usual sign and symptom. The prognosis is more favorable than conventional osteosarcoma.
code: C6474
Semantic_Type: Neoplastic Process
Preferred_Name: Low Grade Central Osteosarcoma
UMLS_CUI: C1266163
ICD-O-3_Code: 9187/3
Neoplastic_Status: Malignant
Legacy_Concept_Name: Low_Grade_Central_Osteosarcoma
has exact synonym: Intraosseous Well-Differentiated Osteogenic Sarcoma
has exact synonym: Intraosseous Well-Differentiated Osteosarcoma
has exact synonym: Low Grade Central Osteosarcoma
has exact synonym: Low Grade Intramedullary Osteosarcoma
has exact synonym: Low-Grade Intramedullary Osteosarcoma
in subset: oncotree slim

Axiom
annotated source: Low Grade Central Osteosarcoma
annotated property: definition
annotated target: A low grade osteosarcoma arising from the medullary portion of the bone. It affects the long bones and is characterized by the presence of fibroblastic stroma and osteoid production. Pain and swelling are the usual sign and symptom. The prognosis is more favorable than conventional osteosarcoma.
def-source: NCI

Axiom
annotated source: Low Grade Central Osteosarcoma
annotated property: has exact synonym
annotated target: Intraosseous Well-Differentiated Osteogenic Sarcoma
term-group: SY
term-source: NCI

Axiom
annotated source: Low Grade Central Osteosarcoma
annotated property: has exact synonym
annotated target: Intraosseous Well-Differentiated Osteosarcoma
term-group: SY
term-source: NCI

Axiom
annotated source: Low Grade Central Osteosarcoma
annotated property: has exact synonym
annotated target: Low Grade Central Osteosarcoma
term-group: PT
term-source: NCI

Axiom
annotated source: Low Grade Central Osteosarcoma
annotated property: has exact synonym
annotated target: Low Grade Intramedullary Osteosarcoma
term-group: SY
term-source: NCI

Axiom
annotated source: Low Grade Central Osteosarcoma
annotated property: has exact synonym
annotated target: Low-Grade Intramedullary Osteosarcoma
term-group: SY
term-source: NCI

Dedifferentiated Chondrosarcoma
type: Class
subclass of: Chondrosarcoma
definition: An aggressive morphologic variant of chondrosarcoma. It is composed of a low grade chondrosarcoma and a high grade non-cartilagenous sarcomatous component. Due to the aggressive nature of the disease, its prognosis is poor.
Concept_In_Subset: NCIT C126659
code: C6476
Semantic_Type: Neoplastic Process
Preferred_Name: Dedifferentiated Chondrosarcoma
UMLS_CUI: C0862878
ICD-O-3_Code: 9243/3
Neoplastic_Status: Malignant
Legacy_Concept_Name: Dedifferentiated_Chondrosarcoma
has exact synonym: Dedifferentiated Chondrosarcoma
in subset: oncotree slim

Axiom
annotated source: Dedifferentiated Chondrosarcoma
annotated property: definition
annotated target: An aggressive morphologic variant of chondrosarcoma. It is composed of a low grade chondrosarcoma and a high grade non-cartilagenous sarcomatous component. Due to the aggressive nature of the disease, its prognosis is poor.
def-source: NCI

Axiom
annotated source: Dedifferentiated Chondrosarcoma
annotated property: has exact synonym
annotated target: Dedifferentiated Chondrosarcoma
term-group: PT
term-source: NCI

Inflammatory Myofibroblastic Tumor
type: Class
definition: A multinodular intermediate fibroblastic neoplasm that arises from soft tissue or viscera, in children and young adults. It is characterized by the presence of spindle-shaped fibroblasts and myofibroblasts, and a chronic inflammatory infiltrate composed of eosinophils, lymphocytes, and plasma cells.
Concept_In_Subset: NCIT C126659
code: C6481
Semantic_Type: Neoplastic Process
Preferred_Name: Inflammatory Myofibroblastic Tumor
UMLS_CUI: C0334121
ICD-O-3_Code: 8825/1
Neoplastic_Status: Undetermined
Legacy_Concept_Name: Inflammatory_Myofibroblastic_Tumor
has exact synonym: IMT
has exact synonym: Inflammatory Fibrosarcoma
has exact synonym: Inflammatory Myofibroblastic Neoplasm
has exact synonym: Inflammatory Myofibroblastic Tumor
has exact synonym: Inflammatory Pseudotumor
in subset: oncotree slim

Axiom
annotated source: Inflammatory Myofibroblastic Tumor
annotated property: definition
annotated target: A multinodular intermediate fibroblastic neoplasm that arises from soft tissue or viscera, in children and young adults. It is characterized by the presence of spindle-shaped fibroblasts and myofibroblasts, and a chronic inflammatory infiltrate composed of eosinophils, lymphocytes, and plasma cells.
def-source: NCI

Axiom
annotated source: Inflammatory Myofibroblastic Tumor
annotated property: has exact synonym
annotated target: IMT
term-group: AB
term-source: NCI

Axiom
annotated source: Inflammatory Myofibroblastic Tumor
annotated property: has exact synonym
annotated target: Inflammatory Fibrosarcoma
term-group: SY
term-source: NCI

Axiom
annotated source: Inflammatory Myofibroblastic Tumor
annotated property: has exact synonym
annotated target: Inflammatory Myofibroblastic Neoplasm
term-group: SY
term-source: NCI

Axiom
annotated source: Inflammatory Myofibroblastic Tumor
annotated property: has exact synonym
annotated target: Inflammatory Myofibroblastic Tumor
term-group: PT
term-source: NCI

Axiom
annotated source: Inflammatory Myofibroblastic Tumor
annotated property: has exact synonym
annotated target: Inflammatory Pseudotumor
term-group: SY
term-source: NCI

Myxofibrosarcoma
type: Class
definition: A malignant fibroblastic neoplasm arising from the soft tissue. It is characterized by the presence of spindle-shaped cells, cellular pleomorphism, thin-walled blood vessels, fibrous septa, and myxoid stroma.
code: C6496
Semantic_Type: Neoplastic Process
Preferred_Name: Myxofibrosarcoma
UMLS_CUI: C0334454
ICD-O-3_Code: 8811/3
Neoplastic_Status: Malignant
Legacy_Concept_Name: Myxoid_Malignant_Fibrous_Histiocytoma
has exact synonym: Myxofibrosarcoma
has exact synonym: Myxoid Fibrous Histiocytoma
has exact synonym: Myxoid MFH
has exact synonym: Myxoid Malignant Fibrous Histiocytoma
in subset: oncotree slim

Axiom
annotated source: Myxofibrosarcoma
annotated property: definition
annotated target: A malignant fibroblastic neoplasm arising from the soft tissue. It is characterized by the presence of spindle-shaped cells, cellular pleomorphism, thin-walled blood vessels, fibrous septa, and myxoid stroma.
def-source: NCI

Axiom
annotated source: Myxofibrosarcoma
annotated property: has exact synonym
annotated target: Myxofibrosarcoma
term-group: PT
term-source: NCI

Axiom
annotated source: Myxofibrosarcoma
annotated property: has exact synonym
annotated target: Myxoid Fibrous Histiocytoma
term-group: AQS
term-source: NCI

Axiom
annotated source: Myxofibrosarcoma
annotated property: has exact synonym
annotated target: Myxoid MFH
term-group: AQS
term-source: NCI

Axiom
annotated source: Myxofibrosarcoma
annotated property: has exact synonym
annotated target: Myxoid Malignant Fibrous Histiocytoma
term-group: AQS
term-source: NCI

Spindle Cell Rhabdomyosarcoma
type: Class
subclass of: Spindle Cell/Sclerosing Rhabdomyosarcoma
definition: An uncommon variant of rhabdomyosarcoma characterized by the presence of whorls of spindle cells forming a storiform pattern. In children it usually arises in the paratesticular region. In adults it usually arises from the deep soft tissues in the head and neck.
Has_NICHD_Parent: Rhabdomyosarcoma
Concept_In_Subset: NCIT C126659
Concept_In_Subset: NCIT C132009
Concept_In_Subset: NCIT C90259
code: C6519
Semantic_Type: Neoplastic Process
Preferred_Name: Spindle Cell Rhabdomyosarcoma
UMLS_CUI: C1266134
Contributing_Source: NICHD
ALT_DEFINITION: An uncommon variant of rhabdomyosarcoma that is characterized by the presence of whorls of spindle cells forming a storiform pattern. In children, it usually arises in the paratesticular region; in adults it usually arises from the deep soft tissues in the head and neck.
ICD-O-3_Code: 8912/3
Neoplastic_Status: Malignant
Legacy_Concept_Name: Spindle_Cell_Rhabdomyosarcoma
NICHD_Hierarchy_Term: Spindle Cell Rhabdomyosarcoma
has exact synonym: Spindle Cell Rhabdomyosarcoma
in subset: oncotree slim

Axiom
annotated source: Spindle Cell Rhabdomyosarcoma
annotated property: definition
annotated target: An uncommon variant of rhabdomyosarcoma characterized by the presence of whorls of spindle cells forming a storiform pattern. In children it usually arises in the paratesticular region. In adults it usually arises from the deep soft tissues in the head and neck.
def-source: NCI

Axiom
annotated source: Spindle Cell Rhabdomyosarcoma
annotated property: ALT_DEFINITION
annotated target: An uncommon variant of rhabdomyosarcoma that is characterized by the presence of whorls of spindle cells forming a storiform pattern. In children, it usually arises in the paratesticular region; in adults it usually arises from the deep soft tissues in the head and neck.
def-source: NICHD

Axiom
annotated source: Spindle Cell Rhabdomyosarcoma
annotated property: has exact synonym
annotated target: Spindle Cell Rhabdomyosarcoma
term-group: PT
term-source: NCI

Axiom
annotated source: Spindle Cell Rhabdomyosarcoma
annotated property: has exact synonym
annotated target: Spindle Cell Rhabdomyosarcoma
term-group: PT
term-source: NICHD

Myxoma
type: Class
definition: A benign soft tissue neoplasm characterized by the presence of spindle and stellate cells, lobulated growth pattern, and myxoid stroma formation.
Concept_In_Subset: NCIT C61410
Concept_In_Subset: NCIT C77526
Concept_In_Subset: NCIT C88025
code: C6577
Semantic_Type: Neoplastic Process
Preferred_Name: Myxoma
UMLS_CUI: C0027149
Contributing_Source: CDISC
ALT_DEFINITION: A benign soft tissue neoplasm with a myxoid stroma formation.
ICD-O-3_Code: 8840/0
Neoplastic_Status: Benign
Legacy_Concept_Name: Myxoma
has exact synonym: MYXOMA, BENIGN
has exact synonym: Myxoma
in subset: oncotree slim

Axiom
annotated source: Myxoma
annotated property: definition
annotated target: A benign soft tissue neoplasm characterized by the presence of spindle and stellate cells, lobulated growth pattern, and myxoid stroma formation.
def-source: NCI

Axiom
annotated source: Myxoma
annotated property: ALT_DEFINITION
annotated target: A benign soft tissue neoplasm with a myxoid stroma formation.
def-source: CDISC

Axiom
annotated source: Myxoma
annotated property: has exact synonym
annotated target: MYXOMA, BENIGN
term-group: PT
term-source: CDISC

Axiom
annotated source: Myxoma
annotated property: has exact synonym
annotated target: Myxoma
term-group: PT
term-source: NCI

Ossifying Fibromyxoid Tumor
type: Class
definition: A rare soft tissue tumor of uncertain lineage characterized by the presence of neoplastic spindle to round cells forming cords in a fibromyxoid stroma. The lesions are associated with the formation of metaplastic bone. Most patients present with painless subcutaneous masses. Recurrences have been reported in a minority of patients.
code: C6582
Semantic_Type: Neoplastic Process
Preferred_Name: Ossifying Fibromyxoid Tumor
UMLS_CUI: C1266128
ICD-O-3_Code: 8842/0
Neoplastic_Status: Benign
Legacy_Concept_Name: Ossifying_Fibromyxoid_Neoplasm
has exact synonym: OFMT
has exact synonym: Ossifying Fibromyxoid Neoplasm
has exact synonym: Ossifying Fibromyxoid Tumor
has exact synonym: Ossifying Fibromyxoma
in subset: oncotree slim

Axiom
annotated source: Ossifying Fibromyxoid Tumor
annotated property: definition
annotated target: A rare soft tissue tumor of uncertain lineage characterized by the presence of neoplastic spindle to round cells forming cords in a fibromyxoid stroma. The lesions are associated with the formation of metaplastic bone. Most patients present with painless subcutaneous masses. Recurrences have been reported in a minority of patients.
def-source: NCI

Axiom
annotated source: Ossifying Fibromyxoid Tumor
annotated property: has exact synonym
annotated target: OFMT
term-group: AB
term-source: NCI

Axiom
annotated source: Ossifying Fibromyxoid Tumor
annotated property: has exact synonym
annotated target: Ossifying Fibromyxoid Neoplasm
term-group: SY
term-source: NCI

Axiom
annotated source: Ossifying Fibromyxoid Tumor
annotated property: has exact synonym
annotated target: Ossifying Fibromyxoid Tumor
term-group: PT
term-source: NCI

Axiom
annotated source: Ossifying Fibromyxoid Tumor
annotated property: has exact synonym
annotated target: Ossifying Fibromyxoma
term-group: SY
term-source: NCI

Rosette-Forming Glioneuronal Tumor of the Fourth Ventricle
type: Class
definition: A central nervous system neoplasm arising from the fourth ventricle. It is characterized by the presence of neurocytes forming pseudorosettes and astrocytes which contain Rosenthal fibers. Cytologic atypia is minimal.
Concept_In_Subset: NCIT C126659
code: C67559
Semantic_Type: Neoplastic Process
Preferred_Name: Rosette-Forming Glioneuronal Tumor of the Fourth Ventricle
UMLS_CUI: C2347979
ICD-O-3_Code: 0000/0
ICD-O-3_Code: 9509/1
Neoplastic_Status: Undetermined
Legacy_Concept_Name: Rosette-Forming_Glioneuronal_Tumor_of_the_Fourth_Ventricle
has exact synonym: Rosette-Forming Glioneuronal Tumor of the Fourth Ventricle
in subset: oncotree slim

Axiom
annotated source: Rosette-Forming Glioneuronal Tumor of the Fourth Ventricle
annotated property: definition
annotated target: A central nervous system neoplasm arising from the fourth ventricle. It is characterized by the presence of neurocytes forming pseudorosettes and astrocytes which contain Rosenthal fibers. Cytologic atypia is minimal.
def-source: NCI

Axiom
annotated source: Rosette-Forming Glioneuronal Tumor of the Fourth Ventricle
annotated property: has exact synonym
annotated target: Rosette-Forming Glioneuronal Tumor of the Fourth Ventricle
term-group: PT
term-source: NCI

Gastric Small Cell Neuroendocrine Carcinoma
type: Class
definition: An aggressive, high-grade and poorly differentiated carcinoma with neuroendocrine differentiation that arises from the stomach. It is characterized by the presence of malignant small cells.
Concept_In_Subset: NCIT C126659
code: C6764
Semantic_Type: Neoplastic Process
Preferred_Name: Gastric Small Cell Neuroendocrine Carcinoma
UMLS_CUI: C1333788
Neoplastic_Status: Malignant
Legacy_Concept_Name: Gastric_Small_Cell_Carcinoma
has exact synonym: Gastric Oat Cell Carcinoma
has exact synonym: Gastric Small Cell Carcinoma
has exact synonym: Gastric Small Cell Neuroendocrine Carcinoma
has exact synonym: Oat Cell Carcinoma of Stomach
has exact synonym: Oat Cell Carcinoma of the Stomach
has exact synonym: Small Cell Carcinoma of Stomach
has exact synonym: Small Cell Carcinoma of the Stomach
in subset: oncotree slim

Axiom
annotated source: Gastric Small Cell Neuroendocrine Carcinoma
annotated property: definition
annotated target: An aggressive, high-grade and poorly differentiated carcinoma with neuroendocrine differentiation that arises from the stomach. It is characterized by the presence of malignant small cells.
def-source: NCI

Axiom
annotated source: Gastric Small Cell Neuroendocrine Carcinoma
annotated property: has exact synonym
annotated target: Gastric Oat Cell Carcinoma
term-group: AQS
term-source: NCI

Axiom
annotated source: Gastric Small Cell Neuroendocrine Carcinoma
annotated property: has exact synonym
annotated target: Gastric Small Cell Carcinoma
term-group: SY
term-source: NCI

Axiom
annotated source: Gastric Small Cell Neuroendocrine Carcinoma
annotated property: has exact synonym
annotated target: Gastric Small Cell Neuroendocrine Carcinoma
term-group: PT
term-source: NCI

Axiom
annotated source: Gastric Small Cell Neuroendocrine Carcinoma
annotated property: has exact synonym
annotated target: Oat Cell Carcinoma of Stomach
term-group: AQS
term-source: NCI

Axiom
annotated source: Gastric Small Cell Neuroendocrine Carcinoma
annotated property: has exact synonym
annotated target: Oat Cell Carcinoma of the Stomach
term-group: AQS
term-source: NCI

Axiom
annotated source: Gastric Small Cell Neuroendocrine Carcinoma
annotated property: has exact synonym
annotated target: Small Cell Carcinoma of Stomach
term-group: SY
term-source: NCI

Axiom
annotated source: Gastric Small Cell Neuroendocrine Carcinoma
annotated property: has exact synonym
annotated target: Small Cell Carcinoma of the Stomach
term-group: SY
term-source: NCI

Prostate Small Cell Carcinoma
type: Class
subclass of: Prostate Neuroendocrine Neoplasm
definition: A neuroendocrine carcinoma of the prostate gland with unfavorable prognosis, composed of small cells containing neurosecretory granules. Approximately half of the cases show a mixture of small cells and adenocarcinoma cells.
Concept_In_Subset: NCIT C126659
code: C6766
Semantic_Type: Neoplastic Process
Preferred_Name: Prostate Small Cell Carcinoma
UMLS_CUI: C1300585
Neoplastic_Status: Malignant
Legacy_Concept_Name: Prostate_Small_Cell_Carcinoma
has exact synonym: Oat Cell Carcinoma of Prostate
has exact synonym: Oat Cell Carcinoma of the Prostate
has exact synonym: Prostate Oat Cell Carcinoma
has exact synonym: Prostate Small Cell Carcinoma
has exact synonym: Prostate Small Cell NEC
has exact synonym: Prostate Small Cell Neuroendocrine Carcinoma
has exact synonym: Small Cell Carcinoma of Prostate
has exact synonym: Small Cell Carcinoma of the Prostate
in subset: oncotree slim

Axiom
annotated source: Prostate Small Cell Carcinoma
annotated property: definition
annotated target: A neuroendocrine carcinoma of the prostate gland with unfavorable prognosis, composed of small cells containing neurosecretory granules. Approximately half of the cases show a mixture of small cells and adenocarcinoma cells.
def-source: NCI

Axiom
annotated source: Prostate Small Cell Carcinoma
annotated property: has exact synonym
annotated target: Oat Cell Carcinoma of Prostate
term-group: AQS
term-source: NCI

Axiom
annotated source: Prostate Small Cell Carcinoma
annotated property: has exact synonym
annotated target: Oat Cell Carcinoma of the Prostate
term-group: AQS
term-source: NCI

Axiom
annotated source: Prostate Small Cell Carcinoma
annotated property: has exact synonym
annotated target: Prostate Oat Cell Carcinoma
term-group: AQS
term-source: NCI

Axiom
annotated source: Prostate Small Cell Carcinoma
annotated property: has exact synonym
annotated target: Prostate Small Cell Carcinoma
term-group: PT
term-source: NCI

Axiom
annotated source: Prostate Small Cell Carcinoma
annotated property: has exact synonym
annotated target: Prostate Small Cell NEC
term-group: SY
term-source: NCI

Axiom
annotated source: Prostate Small Cell Carcinoma
annotated property: has exact synonym
annotated target: Prostate Small Cell Neuroendocrine Carcinoma
term-group: SY
term-source: NCI

Axiom
annotated source: Prostate Small Cell Carcinoma
annotated property: has exact synonym
annotated target: Small Cell Carcinoma of Prostate
term-group: SY
term-source: NCI

Axiom
annotated source: Prostate Small Cell Carcinoma
annotated property: has exact synonym
annotated target: Small Cell Carcinoma of the Prostate
term-group: SY
term-source: NCI

Ependymal Tumor
type: Class
definition: A group of neoplasms which arise from the ependymal lining of the cerebral ventricles and from the remnants of the central canal of the spinal cord. Ependymal tumors occur predominantly in children and young adults with varied morphological features and biological behavior. There are 4 types: ependymoma, anaplastic ependymoma, myxopapillary ependymoma and subependymoma. (WHO)
Concept_In_Subset: NCIT C126659
code: C6770
Semantic_Type: Neoplastic Process
Preferred_Name: Ependymal Tumor
UMLS_CUI: C1333407
ALT_DEFINITION: A type of brain tumor that usually begins in the central canal of the spinal cord. Ependymal tumors may also develop in the cells lining the ventricles of the brain, which produce and store the special fluid (cerebrospinal fluid) that protects the brain and spinal cord.
Neoplastic_Status: Undetermined
Legacy_Concept_Name: Ependymal_Tumor
has exact synonym: Ependymal Neoplasm
has exact synonym: Ependymal Tumor
has exact synonym: ependymal tumor
in subset: oncotree slim

Axiom
annotated source: Ependymal Tumor
annotated property: definition
annotated target: A group of neoplasms which arise from the ependymal lining of the cerebral ventricles and from the remnants of the central canal of the spinal cord. Ependymal tumors occur predominantly in children and young adults with varied morphological features and biological behavior. There are 4 types: ependymoma, anaplastic ependymoma, myxopapillary ependymoma and subependymoma. (WHO)
def-source: NCI
attr: from WHO

Axiom
annotated source: Ependymal Tumor
annotated property: ALT_DEFINITION
annotated target: A type of brain tumor that usually begins in the central canal of the spinal cord. Ependymal tumors may also develop in the cells lining the ventricles of the brain, which produce and store the special fluid (cerebrospinal fluid) that protects the brain and spinal cord.
def-source: NCI-GLOSS

Axiom
annotated source: Ependymal Tumor
annotated property: has exact synonym
annotated target: Ependymal Neoplasm
term-group: SY
term-source: NCI

Axiom
annotated source: Ependymal Tumor
annotated property: has exact synonym
annotated target: Ependymal Tumor
term-group: PT
term-source: NCI

Axiom
annotated source: Ependymal Tumor
annotated property: has exact synonym
annotated target: ependymal tumor
term-group: PT
term-source: NCI-GLOSS
source-code: CDR0000045679

Cutaneous Fibrous Histiocytoma
type: Class
definition: A solitary, slowly growing, nodular mass, most often affecting the extremities. It is composed of fibrous and histiocytic cells which infiltrate the dermis and occasionally the underlying subcutaneous tissue. Usually local excision is curative. Recurrences are reported only in a small minority of cases.
Concept_In_Subset: NCIT C126659
code: C6801
Semantic_Type: Neoplastic Process
Preferred_Name: Cutaneous Fibrous Histiocytoma
UMLS_CUI: C0002991
ICD-O-3_Code: 8832/0
Neoplastic_Status: Benign
Legacy_Concept_Name: Cutaneous_Fibrous_Histiocytoma
has exact synonym: Benign Cutaneous Fibrous Histiocytoma
has exact synonym: Benign Fibrous Cutaneous Histiocytoma
has exact synonym: Benign Fibrous Histiocytoma of Skin
has exact synonym: Benign Fibrous Histiocytoma of the Skin
has exact synonym: Benign Skin Fibrous Histiocytoma
has exact synonym: Cutaneous Fibrous Histiocytoma
has exact synonym: Dermatofibroma
has exact synonym: Fibrous Histiocytoma of Skin
has exact synonym: Fibrous Histiocytoma of the Skin
in subset: oncotree slim

Axiom
annotated source: Cutaneous Fibrous Histiocytoma
annotated property: definition
annotated target: A solitary, slowly growing, nodular mass, most often affecting the extremities. It is composed of fibrous and histiocytic cells which infiltrate the dermis and occasionally the underlying subcutaneous tissue. Usually local excision is curative. Recurrences are reported only in a small minority of cases.
def-source: NCI

Axiom
annotated source: Cutaneous Fibrous Histiocytoma
annotated property: has exact synonym
annotated target: Benign Cutaneous Fibrous Histiocytoma
term-group: SY
term-source: NCI

Axiom
annotated source: Cutaneous Fibrous Histiocytoma
annotated property: has exact synonym
annotated target: Benign Fibrous Cutaneous Histiocytoma
term-group: SY
term-source: NCI

Axiom
annotated source: Cutaneous Fibrous Histiocytoma
annotated property: has exact synonym
annotated target: Benign Fibrous Histiocytoma of Skin
term-group: SY
term-source: NCI

Axiom
annotated source: Cutaneous Fibrous Histiocytoma
annotated property: has exact synonym
annotated target: Benign Fibrous Histiocytoma of the Skin
term-group: SY
term-source: NCI

Axiom
annotated source: Cutaneous Fibrous Histiocytoma
annotated property: has exact synonym
annotated target: Benign Skin Fibrous Histiocytoma
term-group: SY
term-source: NCI

Axiom
annotated source: Cutaneous Fibrous Histiocytoma
annotated property: has exact synonym
annotated target: Cutaneous Fibrous Histiocytoma
term-group: PT
term-source: NCI

Axiom
annotated source: Cutaneous Fibrous Histiocytoma
annotated property: has exact synonym
annotated target: Dermatofibroma
term-group: SY
term-source: NCI

Axiom
annotated source: Cutaneous Fibrous Histiocytoma
annotated property: has exact synonym
annotated target: Fibrous Histiocytoma of Skin
term-group: SY
term-source: NCI

Axiom
annotated source: Cutaneous Fibrous Histiocytoma
annotated property: has exact synonym
annotated target: Fibrous Histiocytoma of the Skin
term-group: SY
term-source: NCI

Testicular Lymphoma
type: Class
definition: A lymphoma that arises from the testis and is not associated with lymphoma in another anatomic site.
Concept_In_Subset: NCIT C116977
code: C6810
Semantic_Type: Neoplastic Process
Display_Name: Testicular Lymphoma
Preferred_Name: Testicular Lymphoma
UMLS_CUI: C0349644
Contributing_Source: CTRP
Neoplastic_Status: Malignant
Legacy_Concept_Name: Testicular_Lymphoma
has exact synonym: Lymphoma of Testis
has exact synonym: Lymphoma of the Testis
has exact synonym: Primary Testicular Lymphoma
has exact synonym: Testicular Lymphoma
in subset: oncotree slim

Axiom
annotated source: Testicular Lymphoma
annotated property: definition
annotated target: A lymphoma that arises from the testis and is not associated with lymphoma in another anatomic site.
def-source: NCI

Axiom
annotated source: Testicular Lymphoma
annotated property: has exact synonym
annotated target: Lymphoma of Testis
term-group: SY
term-source: NCI

Axiom
annotated source: Testicular Lymphoma
annotated property: has exact synonym
annotated target: Lymphoma of the Testis
term-group: SY
term-source: NCI

Axiom
annotated source: Testicular Lymphoma
annotated property: has exact synonym
annotated target: Primary Testicular Lymphoma
term-group: SY
term-source: NCI

Axiom
annotated source: Testicular Lymphoma
annotated property: has exact synonym
annotated target: Testicular Lymphoma
term-group: PT
term-source: NCI

Large Cell Neuroendocrine Carcinoma
type: Class
definition: A usually aggressive carcinoma composed of large malignant cells which display neuroendocrine characteristics. It is characterized by the presence of high mitotic activity and necrotic changes. The vast majority of cases are positive for neuron-specific enolase. Representative examples include lung, breast, cervical, and thymic neuroendocrine carcinomas.
Concept_In_Subset: NCIT C126659
code: C6875
Semantic_Type: Neoplastic Process
Preferred_Name: Large Cell Neuroendocrine Carcinoma
UMLS_CUI: C1265996
ICD-O-3_Code: 8013/3
Neoplastic_Status: Malignant
Legacy_Concept_Name: Large_Cell_Neuroendocrine_Carcinoma
has exact synonym: Large Cell NEC
has exact synonym: Large Cell Neuroendocrine Carcinoma
has exact synonym: Large-cell neuroendocrine carcinoma
in subset: oncotree slim

Axiom
annotated source: Large Cell Neuroendocrine Carcinoma
annotated property: definition
annotated target: A usually aggressive carcinoma composed of large malignant cells which display neuroendocrine characteristics. It is characterized by the presence of high mitotic activity and necrotic changes. The vast majority of cases are positive for neuron-specific enolase. Representative examples include lung, breast, cervical, and thymic neuroendocrine carcinomas.
def-source: NCI

Axiom
annotated source: Large Cell Neuroendocrine Carcinoma
annotated property: has exact synonym
annotated target: Large Cell NEC
term-group: SY
term-source: NCI

Axiom
annotated source: Large Cell Neuroendocrine Carcinoma
annotated property: has exact synonym
annotated target: Large Cell Neuroendocrine Carcinoma
term-group: PT
term-source: NCI

Axiom
annotated source: Large Cell Neuroendocrine Carcinoma
annotated property: has exact synonym
annotated target: Large Cell Neuroendocrine Carcinoma
term-group: SY
term-source: NCI
source-code: TCGA
subsource-name: caDSR

Axiom
annotated source: Large Cell Neuroendocrine Carcinoma
annotated property: has exact synonym
annotated target: Large-cell neuroendocrine carcinoma
term-group: SY
term-source: NCI

Large Cell Lung Carcinoma with Rhabdoid Phenotype
type: Class
subclass of: Large Cell Lung Carcinoma
definition: A rare poorly differentiated morphologic variant of large cell lung carcinoma characterized by the presence of rhabdoid cells.
Concept_In_Subset: NCIT C126659
code: C6876
Semantic_Type: Neoplastic Process
Preferred_Name: Large Cell Lung Carcinoma with Rhabdoid Phenotype
UMLS_CUI: C1265997
ICD-O-3_Code: 8014/3
Neoplastic_Status: Malignant
Legacy_Concept_Name: Large_Cell_Lung_Carcinoma_with_Rhabdoid_Phenotype
has exact synonym: Large Cell Carcinoma with Rhabdoid Phenotype
has exact synonym: Large Cell Lung Carcinoma with Rhabdoid Phenotype
in subset: oncotree slim

Axiom
annotated source: Large Cell Lung Carcinoma with Rhabdoid Phenotype
annotated property: definition
annotated target: A rare poorly differentiated morphologic variant of large cell lung carcinoma characterized by the presence of rhabdoid cells.
def-source: NCI

Axiom
annotated source: Large Cell Lung Carcinoma with Rhabdoid Phenotype
annotated property: has exact synonym
annotated target: Large Cell Carcinoma with Rhabdoid Phenotype
term-group: SY
term-source: NCI

Axiom
annotated source: Large Cell Lung Carcinoma with Rhabdoid Phenotype
annotated property: has exact synonym
annotated target: Large Cell Lung Carcinoma with Rhabdoid Phenotype
term-group: PT
term-source: NCI

Breast Adenomyoepithelioma
type: Class
definition: A usually benign tumor arising from the breast. It is characterized by the proliferation of cells with myoepithelial differentiation around spaces which are lined by epithelial cells. Rarely, the epithelial and/or myoepithelial cells may undergo malignant transformation. Cases with malignant transformation may follow an aggressive clinical course, including recurrences and local and distant metastases.
code: C6899
Semantic_Type: Neoplastic Process
Preferred_Name: Breast Adenomyoepithelioma
UMLS_CUI: C1510795
ICD-O-3_Code: 8983/0
Neoplastic_Status: Benign
Legacy_Concept_Name: Adenomyoepithelioma
has exact synonym: Adenomyoepithelioma of the Breast
has exact synonym: Breast Adenomyoepithelioma
in subset: oncotree slim

Axiom
annotated source: Breast Adenomyoepithelioma
annotated property: definition
annotated target: A usually benign tumor arising from the breast. It is characterized by the proliferation of cells with myoepithelial differentiation around spaces which are lined by epithelial cells. Rarely, the epithelial and/or myoepithelial cells may undergo malignant transformation. Cases with malignant transformation may follow an aggressive clinical course, including recurrences and local and distant metastases.
def-source: NCI

Axiom
annotated source: Breast Adenomyoepithelioma
annotated property: has exact synonym
annotated target: Adenomyoepithelioma of the Breast
term-group: SY
term-source: NCI

Axiom
annotated source: Breast Adenomyoepithelioma
annotated property: has exact synonym
annotated target: Breast Adenomyoepithelioma
term-group: PT
term-source: NCI

Epithelioid Trophoblastic Tumor
type: Class
subclass of: Gestational Trophoblastic Tumor
definition: A gestational trophoblastic tumor characterized by the presence of a monomorphous cellular population of intermediate trophoblastic cells infiltrating in a nodular pattern.
Concept_In_Subset: NCIT C116977
code: C6900
Semantic_Type: Neoplastic Process
Display_Name: Epithelioid Trophoblastic Tumor
Preferred_Name: Epithelioid Trophoblastic Tumor
UMLS_CUI: C1266159
Contributing_Source: CTRP
ICD-O-3_Code: 9105/3
Neoplastic_Status: Undetermined
Legacy_Concept_Name: Epithelioid_Trophoblastic_Tumor
has exact synonym: Epithelioid Trophoblastic Tumor
in subset: oncotree slim

Axiom
annotated source: Epithelioid Trophoblastic Tumor
annotated property: definition
annotated target: A gestational trophoblastic tumor characterized by the presence of a monomorphous cellular population of intermediate trophoblastic cells infiltrating in a nodular pattern.
def-source: NCI

Axiom
annotated source: Epithelioid Trophoblastic Tumor
annotated property: has exact synonym
annotated target: Epithelioid Trophoblastic Tumor
term-group: PT
term-source: NCI

Large Cell Medulloblastoma
type: Class
subclass of: Medulloblastoma
definition: A medulloblastoma composed of large cells with prominent nucleoli and a larger amount of cytoplasm in contrast with the cells of the classic medulloblastoma.
Concept_In_Subset: NCIT C126659
code: C6904
Semantic_Type: Neoplastic Process
Preferred_Name: Large Cell Medulloblastoma
UMLS_CUI: C1266180
ICD-O-3_Code: 9474/3
Neoplastic_Status: Malignant
Legacy_Concept_Name: Large_Cell_Medulloblastoma
has exact synonym: Large Cell Medulloblastoma
in subset: oncotree slim

Axiom
annotated source: Large Cell Medulloblastoma
annotated property: definition
annotated target: A medulloblastoma composed of large cells with prominent nucleoli and a larger amount of cytoplasm in contrast with the cells of the classic medulloblastoma.
def-source: NCI

Axiom
annotated source: Large Cell Medulloblastoma
annotated property: has exact synonym
annotated target: Large Cell Medulloblastoma
term-group: PT
term-source: NCI

Axiom
annotated source: Large Cell Medulloblastoma
annotated property: has exact synonym
annotated target: Large Cell Medulloblastoma
term-group: SY
term-source: NCI
source-code: TCGA
subsource-name: caDSR

Cerebellar Liponeurocytoma
type: Class
definition: A rare, WHO grade II cerebellar neoplasm which shows consistent neuronal, variable astrocytic and focal lipomatous differentiation. It occurs in adults, has a low proliferative potential and usually has a favorable prognosis. (Adapted from WHO)
Concept_In_Subset: NCIT C126659
code: C6905
Semantic_Type: Neoplastic Process
Preferred_Name: Cerebellar Liponeurocytoma
UMLS_CUI: C1370507
ICD-O-3_Code: 0000/0
Neoplastic_Status: Undetermined
Legacy_Concept_Name: Cerebellar_Liponeurocytoma
has exact synonym: Cerebellar Liponeurocytoma
has exact synonym: Cerebellar Liponeurocytoma (WHO Grade II)
has exact synonym: Lipomatous Medulloblastoma
in subset: oncotree slim

Axiom
annotated source: Cerebellar Liponeurocytoma
annotated property: definition
annotated target: A rare, WHO grade II cerebellar neoplasm which shows consistent neuronal, variable astrocytic and focal lipomatous differentiation. It occurs in adults, has a low proliferative potential and usually has a favorable prognosis. (Adapted from WHO)
def-source: NCI

Axiom
annotated source: Cerebellar Liponeurocytoma
annotated property: has exact synonym
annotated target: Cerebellar Liponeurocytoma
term-group: PT
term-source: NCI

Axiom
annotated source: Cerebellar Liponeurocytoma
annotated property: has exact synonym
annotated target: Cerebellar Liponeurocytoma (WHO Grade II)
term-group: SY
term-source: NCI

Axiom
annotated source: Cerebellar Liponeurocytoma
annotated property: has exact synonym
annotated target: Lipomatous Medulloblastoma
term-group: SY
term-source: NCI

Atypical Teratoid/Rhabdoid Tumor
type: Class
subclass of: Rhabdoid Tumor
definition: An aggressive malignant embryonal neoplasm arising from the central nervous system. It is composed of cells with a large eccentric nucleus, prominent nucleolus, and abundant cytoplasm. Mutations of the INI1 gene or very rarely SMARCA4 (BRG1) gene are present. The vast majority of cases occur in childhood. Symptoms include lethargy, vomiting, cranial nerve palsy, headache, and hemiplegia.
Concept_In_Subset: NCIT C102905
Concept_In_Subset: NCIT C103046
Concept_In_Subset: NCIT C126659
code: C6906
Semantic_Type: Neoplastic Process
Preferred_Name: Atypical Teratoid/Rhabdoid Tumor
UMLS_CUI: C1266184
Contributing_Source: CTEP
ALT_DEFINITION: An aggressive cancer of the central nervous system, kidney, or liver that occurs in very young children.
ICD-O-3_Code: 9508/3
Neoplastic_Status: Malignant
Legacy_Concept_Name: Atypical_Teratoid_Rhabdoid_Tumor
has exact synonym: AT/RT
has exact synonym: ATT/RHT
has exact synonym: Atypical Teratoid/Rhabdoid Tumor
has exact synonym: Atypical Teratoid/Rhabdoid Tumor (WHO Grade IV)
has exact synonym: Atypical teratoid/rhabdoid tumor
has exact synonym: CNS Rhabdoid Neoplasm
has exact synonym: CNS Rhabdoid Tumor
has exact synonym: Central Nervous System Rhabdoid Neoplasm
has exact synonym: Central Nervous System Rhabdoid Tumor
has exact synonym: Malignant Brain Rhabdoid Neoplasm
has exact synonym: Malignant Brain Rhabdoid Tumor
has exact synonym: Malignant Rhabdoid Neoplasm of Brain
has exact synonym: Malignant Rhabdoid Neoplasm of the Brain
has exact synonym: Malignant Rhabdoid Tumor of Brain
has exact synonym: Malignant Rhabdoid Tumor of the Brain
has exact synonym: Primary Malignant Brain Rhabdoid Neoplasm
has exact synonym: Primary Malignant Brain Rhabdoid Tumor
has exact synonym: Primary Malignant Rhabdoid Neoplasm of Brain
has exact synonym: Primary Malignant Rhabdoid Neoplasm of the Brain
has exact synonym: Primary Malignant Rhabdoid Tumor of Brain
has exact synonym: Primary Malignant Rhabdoid Tumor of the Brain
has exact synonym: Rhabdoid Neoplasm of CNS
has exact synonym: Rhabdoid Neoplasm of Central Nervous System
has exact synonym: Rhabdoid Neoplasm of the CNS
has exact synonym: Rhabdoid Neoplasm of the Central Nervous System
has exact synonym: Rhabdoid Tumor of CNS
has exact synonym: Rhabdoid Tumor of Central Nervous System
has exact synonym: Rhabdoid Tumor of the CNS
has exact synonym: Rhabdoid Tumor of the Central Nervous System
has exact synonym: atypical teratoid/rhabdoid tumor
in subset: oncotree slim

Axiom
annotated source: Atypical Teratoid/Rhabdoid Tumor
annotated property: definition
annotated target: An aggressive malignant embryonal neoplasm arising from the central nervous system. It is composed of cells with a large eccentric nucleus, prominent nucleolus, and abundant cytoplasm. Mutations of the INI1 gene or very rarely SMARCA4 (BRG1) gene are present. The vast majority of cases occur in childhood. Symptoms include lethargy, vomiting, cranial nerve palsy, headache, and hemiplegia.
def-source: NCI

Axiom
annotated source: Atypical Teratoid/Rhabdoid Tumor
annotated property: ALT_DEFINITION
annotated target: An aggressive cancer of the central nervous system, kidney, or liver that occurs in very young children.
def-source: NCI-GLOSS

Axiom
annotated source: Atypical Teratoid/Rhabdoid Tumor
annotated property: has exact synonym
annotated target: AT/RT
term-group: AB
term-source: NCI

Axiom
annotated source: Atypical Teratoid/Rhabdoid Tumor
annotated property: has exact synonym
annotated target: AT/RT
term-group: PT
term-source: NCI-GLOSS
source-code: CDR0000584380

Axiom
annotated source: Atypical Teratoid/Rhabdoid Tumor
annotated property: has exact synonym
annotated target: ATT/RHT
term-group: PT
term-source: NCI-GLOSS
source-code: CDR0000584379

Axiom
annotated source: Atypical Teratoid/Rhabdoid Tumor
annotated property: has exact synonym
annotated target: Atypical Teratoid/Rhabdoid Tumor
term-group: PT
term-source: NCI

Axiom
annotated source: Atypical Teratoid/Rhabdoid Tumor
annotated property: has exact synonym
annotated target: Atypical Teratoid/Rhabdoid Tumor
term-group: SY
term-source: NCI
source-code: TCGA
subsource-name: caDSR

Axiom
annotated source: Atypical Teratoid/Rhabdoid Tumor
annotated property: has exact synonym
annotated target: Atypical Teratoid/Rhabdoid Tumor (WHO Grade IV)
term-group: SY
term-source: NCI

Axiom
annotated source: Atypical Teratoid/Rhabdoid Tumor
annotated property: has exact synonym
annotated target: Atypical teratoid/rhabdoid tumor
term-group: PT
term-source: CTEP
source-code: 10065870
subsource-name: SDC

Axiom
annotated source: Atypical Teratoid/Rhabdoid Tumor
annotated property: has exact synonym
annotated target: CNS Rhabdoid Neoplasm
term-group: SY
term-source: NCI

Axiom
annotated source: Atypical Teratoid/Rhabdoid Tumor
annotated property: has exact synonym
annotated target: CNS Rhabdoid Tumor
term-group: SY
term-source: NCI

Axiom
annotated source: Atypical Teratoid/Rhabdoid Tumor
annotated property: has exact synonym
annotated target: Central Nervous System Rhabdoid Neoplasm
term-group: SY
term-source: NCI

Axiom
annotated source: Atypical Teratoid/Rhabdoid Tumor
annotated property: has exact synonym
annotated target: Central Nervous System Rhabdoid Tumor
term-group: SY
term-source: NCI

Axiom
annotated source: Atypical Teratoid/Rhabdoid Tumor
annotated property: has exact synonym
annotated target: Malignant Brain Rhabdoid Neoplasm
term-group: SY
term-source: NCI

Axiom
annotated source: Atypical Teratoid/Rhabdoid Tumor
annotated property: has exact synonym
annotated target: Malignant Brain Rhabdoid Tumor
term-group: SY
term-source: NCI

Axiom
annotated source: Atypical Teratoid/Rhabdoid Tumor
annotated property: has exact synonym
annotated target: Malignant Rhabdoid Neoplasm of Brain
term-group: SY
term-source: NCI

Axiom
annotated source: Atypical Teratoid/Rhabdoid Tumor
annotated property: has exact synonym
annotated target: Malignant Rhabdoid Neoplasm of the Brain
term-group: SY
term-source: NCI

Axiom
annotated source: Atypical Teratoid/Rhabdoid Tumor
annotated property: has exact synonym
annotated target: Malignant Rhabdoid Tumor of Brain
term-group: SY
term-source: NCI

Axiom
annotated source: Atypical Teratoid/Rhabdoid Tumor
annotated property: has exact synonym
annotated target: Malignant Rhabdoid Tumor of the Brain
term-group: SY
term-source: NCI

Axiom
annotated source: Atypical Teratoid/Rhabdoid Tumor
annotated property: has exact synonym
annotated target: Primary Malignant Brain Rhabdoid Neoplasm
term-group: SY
term-source: NCI

Axiom
annotated source: Atypical Teratoid/Rhabdoid Tumor
annotated property: has exact synonym
annotated target: Primary Malignant Brain Rhabdoid Tumor
term-group: SY
term-source: NCI

Axiom
annotated source: Atypical Teratoid/Rhabdoid Tumor
annotated property: has exact synonym
annotated target: Primary Malignant Rhabdoid Neoplasm of Brain
term-group: SY
term-source: NCI

Axiom
annotated source: Atypical Teratoid/Rhabdoid Tumor
annotated property: has exact synonym
annotated target: Primary Malignant Rhabdoid Neoplasm of the Brain
term-group: SY
term-source: NCI

Axiom
annotated source: Atypical Teratoid/Rhabdoid Tumor
annotated property: has exact synonym
annotated target: Primary Malignant Rhabdoid Tumor of Brain
term-group: SY
term-source: NCI

Axiom
annotated source: Atypical Teratoid/Rhabdoid Tumor
annotated property: has exact synonym
annotated target: Primary Malignant Rhabdoid Tumor of the Brain
term-group: SY
term-source: NCI

Axiom
annotated source: Atypical Teratoid/Rhabdoid Tumor
annotated property: has exact synonym
annotated target: Rhabdoid Neoplasm of CNS
term-group: SY
term-source: NCI

Axiom
annotated source: Atypical Teratoid/Rhabdoid Tumor
annotated property: has exact synonym
annotated target: Rhabdoid Neoplasm of Central Nervous System
term-group: SY
term-source: NCI

Axiom
annotated source: Atypical Teratoid/Rhabdoid Tumor
annotated property: has exact synonym
annotated target: Rhabdoid Neoplasm of the CNS
term-group: SY
term-source: NCI

Axiom
annotated source: Atypical Teratoid/Rhabdoid Tumor
annotated property: has exact synonym
annotated target: Rhabdoid Neoplasm of the Central Nervous System
term-group: SY
term-source: NCI

Axiom
annotated source: Atypical Teratoid/Rhabdoid Tumor
annotated property: has exact synonym
annotated target: Rhabdoid Tumor of CNS
term-group: SY
term-source: NCI

Axiom
annotated source: Atypical Teratoid/Rhabdoid Tumor
annotated property: has exact synonym
annotated target: Rhabdoid Tumor of Central Nervous System
term-group: SY
term-source: NCI

Axiom
annotated source: Atypical Teratoid/Rhabdoid Tumor
annotated property: has exact synonym
annotated target: Rhabdoid Tumor of the CNS
term-group: SY
term-source: NCI

Axiom
annotated source: Atypical Teratoid/Rhabdoid Tumor
annotated property: has exact synonym
annotated target: Rhabdoid Tumor of the Central Nervous System
term-group: SY
term-source: NCI

Axiom
annotated source: Atypical Teratoid/Rhabdoid Tumor
annotated property: has exact synonym
annotated target: atypical teratoid/rhabdoid tumor
term-group: PT
term-source: NCI-GLOSS
source-code: CDR0000285639

Chordoid Meningioma
type: Class
definition: A WHO grade II, usually recurring meningioma characterized by the predominance of tissues that are histologically similar to chordoma.
Concept_In_Subset: NCIT C126659
code: C6908
Semantic_Type: Neoplastic Process
Preferred_Name: Chordoid Meningioma
UMLS_CUI: C1370510
Neoplastic_Status: Undetermined
Legacy_Concept_Name: Chordoid_Meningioma
has exact synonym: Chordoid Meningioma
in subset: oncotree slim

Axiom
annotated source: Chordoid Meningioma
annotated property: definition
annotated target: A WHO grade II, usually recurring meningioma characterized by the predominance of tissues that are histologically similar to chordoma.
def-source: NCI

Axiom
annotated source: Chordoid Meningioma
annotated property: has exact synonym
annotated target: Chordoid Meningioma
term-group: PT
term-source: NCI

Axiom
annotated source: Chordoid Meningioma
annotated property: has exact synonym
annotated target: Chordoid Meningioma
term-group: SY
term-source: NCI
source-code: TCGA
subsource-name: caDSR

Rhabdoid Meningioma
type: Class
definition: A WHO grade III meningioma characterized by the predominant presence of rhabdoid cells forming sheets.
Concept_In_Subset: NCIT C126659
code: C6909
Semantic_Type: Neoplastic Process
Preferred_Name: Rhabdoid Meningioma
UMLS_CUI: C0259786
Neoplastic_Status: Malignant
Legacy_Concept_Name: Rhabdoid_Meningioma
has exact synonym: Rhabdoid Meningioma
in subset: oncotree slim

Axiom
annotated source: Rhabdoid Meningioma
annotated property: definition
annotated target: A WHO grade III meningioma characterized by the predominant presence of rhabdoid cells forming sheets.
def-source: NCI

Axiom
annotated source: Rhabdoid Meningioma
annotated property: has exact synonym
annotated target: Rhabdoid Meningioma
term-group: PT
term-source: NCI

Axiom
annotated source: Rhabdoid Meningioma
annotated property: has exact synonym
annotated target: Rhabdoid Meningioma
term-group: SY
term-source: NCI
source-code: TCGA
subsource-name: caDSR

Gangliocytoma
type: Class
definition: A well differentiated, slow growing neuroepithelial neoplasm composed of neoplastic, mature ganglion cells.
Concept_In_Subset: NCIT C126659
code: C6934
Semantic_Type: Neoplastic Process
Preferred_Name: Gangliocytoma
NCI_META_CUI: CL378224
ICD-O-3_Code: 9492/0
Neoplastic_Status: Undetermined
Legacy_Concept_Name: Gangliocytoma
has exact synonym: Gangliocytoma
in subset: oncotree slim

Axiom
annotated source: Gangliocytoma
annotated property: definition
annotated target: A well differentiated, slow growing neuroepithelial neoplasm composed of neoplastic, mature ganglion cells.
def-source: NCI

Axiom
annotated source: Gangliocytoma
annotated property: has exact synonym
annotated target: Gangliocytoma
term-group: PT
term-source: NCI

Axiom
annotated source: Gangliocytoma
annotated property: has exact synonym
annotated target: Gangliocytoma
term-group: SY
term-source: NCI
source-code: TCGA
subsource-name: caDSR

Sweat Gland Carcinoma
type: Class
subclass of: Adnexal Carcinoma
definition: A carcinoma arising from the sweat glands. Representative examples include tubular carcinoma, spiradenocarcinoma, eccrine carcinoma, hidradenocarcinoma, and apocrine carcinoma.
Concept_In_Subset: NCIT C126659
Concept_In_Subset: NCIT C61410
Concept_In_Subset: NCIT C77526
Concept_In_Subset: NCIT C88025
code: C6938
Semantic_Type: Neoplastic Process
Preferred_Name: Sweat Gland Carcinoma
UMLS_CUI: C1412016
Contributing_Source: CDISC
ALT_DEFINITION: A malignant neoplasm arising from sweat glands.
ICD-O-3_Code: 8400/3
Neoplastic_Status: Malignant
Legacy_Concept_Name: Sweat_Gland_Carcinoma
has exact synonym: CARCINOMA, SWEAT GLAND, MALIGNANT
has exact synonym: Carcinoma of Sweat Gland
has exact synonym: Carcinoma of the Sweat Gland
has exact synonym: Sweat Gland Carcinoma
in subset: oncotree slim

Axiom
annotated source: Sweat Gland Carcinoma
annotated property: definition
annotated target: A carcinoma arising from the sweat glands. Representative examples include tubular carcinoma, spiradenocarcinoma, eccrine carcinoma, hidradenocarcinoma, and apocrine carcinoma.
def-source: NCI

Axiom
annotated source: Sweat Gland Carcinoma
annotated property: ALT_DEFINITION
annotated target: A malignant neoplasm arising from sweat glands.
def-source: CDISC

Axiom
annotated source: Sweat Gland Carcinoma
annotated property: has exact synonym
annotated target: CARCINOMA, SWEAT GLAND, MALIGNANT
term-group: PT
term-source: CDISC

Axiom
annotated source: Sweat Gland Carcinoma
annotated property: has exact synonym
annotated target: Carcinoma of Sweat Gland
term-group: SY
term-source: CDISC

Axiom
annotated source: Sweat Gland Carcinoma
annotated property: has exact synonym
annotated target: Carcinoma of Sweat Gland
term-group: SY
term-source: NCI

Axiom
annotated source: Sweat Gland Carcinoma
annotated property: has exact synonym
annotated target: Carcinoma of the Sweat Gland
term-group: SY
term-source: CDISC

Axiom
annotated source: Sweat Gland Carcinoma
annotated property: has exact synonym
annotated target: Carcinoma of the Sweat Gland
term-group: SY
term-source: NCI

Axiom
annotated source: Sweat Gland Carcinoma
annotated property: has exact synonym
annotated target: Sweat Gland Carcinoma
term-group: PT
term-source: NCI

Anaplastic Oligoastrocytoma
type: Class
definition: An oligoastrocytoma characterized by the presence of increased cellularity, nuclear atypia, pleomorphism, and high mitotic activity.
Concept_In_Subset: NCIT C126659
code: C6959
Semantic_Type: Neoplastic Process
Preferred_Name: Anaplastic Oligoastrocytoma
UMLS_CUI: C0431108
Neoplastic_Status: Malignant
Legacy_Concept_Name: Anaplastic_Oligoastrocytoma
has exact synonym: Anaplastic Mixed Glioma
has exact synonym: Anaplastic Oligoastrocytoma
has exact synonym: WHO Grade III Mixed Glioma
in subset: oncotree slim

Axiom
annotated source: Anaplastic Oligoastrocytoma
annotated property: definition
annotated target: An oligoastrocytoma characterized by the presence of increased cellularity, nuclear atypia, pleomorphism, and high mitotic activity.
def-source: NCI

Axiom
annotated source: Anaplastic Oligoastrocytoma
annotated property: has exact synonym
annotated target: Anaplastic Mixed Glioma
term-group: SY
term-source: NCI

Axiom
annotated source: Anaplastic Oligoastrocytoma
annotated property: has exact synonym
annotated target: Anaplastic Oligoastrocytoma
term-group: PT
term-source: NCI

Axiom
annotated source: Anaplastic Oligoastrocytoma
annotated property: has exact synonym
annotated target: Anaplastic Oligoastrocytoma
term-group: SY
term-source: NCI
source-code: TCGA
subsource-name: caDSR

Axiom
annotated source: Anaplastic Oligoastrocytoma
annotated property: has exact synonym
annotated target: WHO Grade III Mixed Glioma
term-group: SY
term-source: NCI

Pineocytoma
type: Class
definition: A WHO grade I slow growing tumor, more frequently affecting young adults. It is composed of small, uniform, mature cells resembling pineocytes with occasional large pineocytomatous rosettes. It may show a wide range of divergent phenotypes, including neuronal, glial, melanocytic, photoreceptor and mesenchymal differentiation. Pineocytoma generally has a relatively favorable prognosis. (Adapted from WHO)
Has_NICHD_Parent: NCIT C115196
Concept_In_Subset: NCIT C126659
Concept_In_Subset: NCIT C132009
Concept_In_Subset: NCIT C61410
Concept_In_Subset: NCIT C77526
Concept_In_Subset: NCIT C88025
Concept_In_Subset: NCIT C90259
code: C6966
Semantic_Type: Neoplastic Process
Preferred_Name: Pineocytoma
UMLS_CUI: C0917890
Contributing_Source: CDISC
Contributing_Source: NICHD
ALT_DEFINITION: A benign neoplasm of the brain arising from the pineal gland.
ALT_DEFINITION: A benign, slow growing, pineal parenchymal tumor that more frequently affects young adults.
ALT_DEFINITION: A slow growing type of brain tumor that occurs in or around the pineal gland, a tiny organ near the center of the brain.
ICD-O-3_Code: 9361/1
Neoplastic_Status: Benign
Legacy_Concept_Name: Pineocytoma
NICHD_Hierarchy_Term: Pineocytoma
has exact synonym: Benign Pinealoma
has exact synonym: PINEOCYTOMA, BENIGN
has exact synonym: Pinealocytoma
has exact synonym: Pineocytoma
has exact synonym: Pineocytoma (WHO Grade I)
has exact synonym: pineocytoma
in subset: oncotree slim

Axiom
annotated source: Pineocytoma
annotated property: definition
annotated target: A WHO grade I slow growing tumor, more frequently affecting young adults. It is composed of small, uniform, mature cells resembling pineocytes with occasional large pineocytomatous rosettes. It may show a wide range of divergent phenotypes, including neuronal, glial, melanocytic, photoreceptor and mesenchymal differentiation. Pineocytoma generally has a relatively favorable prognosis. (Adapted from WHO)
def-source: NCI

Axiom
annotated source: Pineocytoma
annotated property: ALT_DEFINITION
annotated target: A benign neoplasm of the brain arising from the pineal gland.
def-source: CDISC

Axiom
annotated source: Pineocytoma
annotated property: ALT_DEFINITION
annotated target: A benign, slow growing, pineal parenchymal tumor that more frequently affects young adults.
def-source: NICHD

Axiom
annotated source: Pineocytoma
annotated property: ALT_DEFINITION
annotated target: A slow growing type of brain tumor that occurs in or around the pineal gland, a tiny organ near the center of the brain.
def-source: NCI-GLOSS

Axiom
annotated source: Pineocytoma
annotated property: has exact synonym
annotated target: Benign Pinealoma
term-group: SY
term-source: CDISC

Axiom
annotated source: Pineocytoma
annotated property: has exact synonym
annotated target: Benign Pinealoma
term-group: SY
term-source: NICHD

Axiom
annotated source: Pineocytoma
annotated property: has exact synonym
annotated target: PINEOCYTOMA, BENIGN
term-group: PT
term-source: CDISC

Axiom
annotated source: Pineocytoma
annotated property: has exact synonym
annotated target: Pinealocytoma
term-group: SY
term-source: NICHD

Axiom
annotated source: Pineocytoma
annotated property: has exact synonym
annotated target: Pineocytoma
term-group: PT
term-source: NCI

Axiom
annotated source: Pineocytoma
annotated property: has exact synonym
annotated target: Pineocytoma
term-group: PT
term-source: NICHD

Axiom
annotated source: Pineocytoma
annotated property: has exact synonym
annotated target: Pineocytoma
term-group: SY
term-source: NCI
source-code: TCGA
subsource-name: caDSR

Axiom
annotated source: Pineocytoma
annotated property: has exact synonym
annotated target: Pineocytoma (WHO Grade I)
term-group: SY
term-source: NCI

Axiom
annotated source: Pineocytoma
annotated property: has exact synonym
annotated target: pineocytoma
term-group: PT
term-source: NCI-GLOSS
source-code: CDR0000046228

Pineal Parenchymal Tumor of Intermediate Differentiation
type: Class
definition: A WHO grade II or III pineal parenchymal neoplasm of intermediate-grade malignancy, affecting all ages. It is composed of diffuse sheets or large lobules of uniform cells with mild to moderate nuclear atypia and low to moderate level mitotic activity. (Adapted from WHO)
Concept_In_Subset: NCIT C126659
code: C6967
Semantic_Type: Neoplastic Process
Preferred_Name: Pineal Parenchymal Tumor of Intermediate Differentiation
UMLS_CUI: C1367859
Neoplastic_Status: Undetermined
Legacy_Concept_Name: Pineal_Parenchymal_Tumor_of_Intermediate_Differentiation
has exact synonym: Pineal Parenchymal Tumor of Intermediate Differentiation
in subset: oncotree slim

Axiom
annotated source: Pineal Parenchymal Tumor of Intermediate Differentiation
annotated property: definition
annotated target: A WHO grade II or III pineal parenchymal neoplasm of intermediate-grade malignancy, affecting all ages. It is composed of diffuse sheets or large lobules of uniform cells with mild to moderate nuclear atypia and low to moderate level mitotic activity. (Adapted from WHO)
def-source: NCI

Axiom
annotated source: Pineal Parenchymal Tumor of Intermediate Differentiation
annotated property: has exact synonym
annotated target: Pineal Parenchymal Tumor of Intermediate Differentiation
term-group: PT
term-source: NCI

Axiom
annotated source: Pineal Parenchymal Tumor of Intermediate Differentiation
annotated property: has exact synonym
annotated target: Pineal Parenchymal Tumor of Intermediate Differentiation
term-group: SY
term-source: NCI
source-code: TCGA
subsource-name: caDSR

Melanotic Schwannoma
type: Class
subclass of: Nerve Sheath Neoplasm
definition: A rare circumscribed, non-encapsulated and grossly pigmented nerve sheath tumor. It is composed of cells with the immunophenotypic and electron microscopic features of Schwann cells which contain melanosomes and are positive for melanoma markers. It usually involves spinal nerve roots but may occur in other locations. It may be associated with PRKAR1A gene mutation and Carney complex. Malignant behavior has been reported in a significant number of patients.
code: C6970
Semantic_Type: Neoplastic Process
Preferred_Name: Melanotic Schwannoma
UMLS_CUI: C1306247
Neoplastic_Status: Undetermined
Legacy_Concept_Name: Melanocytic_Schwannoma
has exact synonym: Melanocytic Neurilemmoma
has exact synonym: Melanocytic Schwannoma
has exact synonym: Melanotic Neurilemmoma
has exact synonym: Melanotic Neurinoma
has exact synonym: Melanotic Schwannoma
has exact synonym: Pigmented Neurilemmoma
has exact synonym: Pigmented Schwannoma
in subset: oncotree slim

Axiom
annotated source: Melanotic Schwannoma
annotated property: definition
annotated target: A rare circumscribed, non-encapsulated and grossly pigmented nerve sheath tumor. It is composed of cells with the immunophenotypic and electron microscopic features of Schwann cells which contain melanosomes and are positive for melanoma markers. It usually involves spinal nerve roots but may occur in other locations. It may be associated with PRKAR1A gene mutation and Carney complex. Malignant behavior has been reported in a significant number of patients.
def-source: NCI

Axiom
annotated source: Melanotic Schwannoma
annotated property: has exact synonym
annotated target: Melanocytic Neurilemmoma
term-group: SY
term-source: NCI

Axiom
annotated source: Melanotic Schwannoma
annotated property: has exact synonym
annotated target: Melanocytic Schwannoma
term-group: SY
term-source: NCI

Axiom
annotated source: Melanotic Schwannoma
annotated property: has exact synonym
annotated target: Melanotic Neurilemmoma
term-group: SY
term-source: NCI

Axiom
annotated source: Melanotic Schwannoma
annotated property: has exact synonym
annotated target: Melanotic Neurinoma
term-group: SY
term-source: NCI

Axiom
annotated source: Melanotic Schwannoma
annotated property: has exact synonym
annotated target: Melanotic Schwannoma
term-group: PT
term-source: NCI

Axiom
annotated source: Melanotic Schwannoma
annotated property: has exact synonym
annotated target: Melanotic Schwannoma
term-group: SY
term-source: NCI
source-code: TCGA
subsource-name: caDSR

Axiom
annotated source: Melanotic Schwannoma
annotated property: has exact synonym
annotated target: Pigmented Neurilemmoma
term-group: SY
term-source: NCI

Axiom
annotated source: Melanotic Schwannoma
annotated property: has exact synonym
annotated target: Pigmented Schwannoma
term-group: SY
term-source: NCI

Neoplasm of Uncertain Histogenesis
type: Class
code: C6974
Semantic_Type: Neoplastic Process
Preferred_Name: Neoplasm of Uncertain Histogenesis
UMLS_CUI: C1334936
Neoplastic_Status: Undetermined
Legacy_Concept_Name: Neoplasm_of_Uncertain_Histogenesis
has exact synonym: Neoplasm of Uncertain Histogenesis
has exact synonym: Neoplasm of Uncertain Origin
has exact synonym: Tumor of Uncertain Histogenesis
has exact synonym: Tumor of Uncertain Origin
in subset: oncotree slim

Axiom
annotated source: Neoplasm of Uncertain Histogenesis
annotated property: has exact synonym
annotated target: Neoplasm of Uncertain Histogenesis
term-group: PT
term-source: NCI

Axiom
annotated source: Neoplasm of Uncertain Histogenesis
annotated property: has exact synonym
annotated target: Neoplasm of Uncertain Origin
term-group: SY
term-source: NCI

Axiom
annotated source: Neoplasm of Uncertain Histogenesis
annotated property: has exact synonym
annotated target: Tumor of Uncertain Histogenesis
term-group: SY
term-source: NCI

Axiom
annotated source: Neoplasm of Uncertain Histogenesis
annotated property: has exact synonym
annotated target: Tumor of Uncertain Origin
term-group: SY
term-source: NCI

Papillary Renal Cell Carcinoma
type: Class
subclass of: NCIT C9385
definition: Also known as chromophil carcinoma, it represents a minority of renal cell carcinomas. It can be hereditary or sporadic. The sporadic papillary renal cell carcinoma is characterized by trisomy of chromosomes 7, 16, and 17, and loss of chromosome Y. The peak incidence is in the sixth and seven decades. It is classified as type 1 or 2, based on the cytoplasmic volume and the thickness of the lining neoplastic cells. The prognosis is more favorable than for conventional (clear cell) renal cell carcinoma. -- 2003
Concept_In_Subset: NCIT C102905
Concept_In_Subset: NCIT C103084
Concept_In_Subset: NCIT C116977
Concept_In_Subset: NCIT C126659
code: C6975
Semantic_Type: Neoplastic Process
Display_Name: Papillary Renal Cell Cancer
Preferred_Name: Papillary Renal Cell Carcinoma
UMLS_CUI: C1306837
Contributing_Source: CTEP
Contributing_Source: CTRP
Neoplastic_Status: Malignant
Legacy_Concept_Name: Papillary_Renal_Cell_Carcinoma
has exact synonym: Chromophil Carcinoma of Kidney
has exact synonym: Chromophil Carcinoma of the Kidney
has exact synonym: Chromophil Renal Cell Carcinoma
has exact synonym: Papillary (Chromophil) Renal Cell Carcinoma
has exact synonym: Papillary Renal Cell Cancer
has exact synonym: Papillary Renal Cell Carcinoma
has exact synonym: Papillary renal cell carcinoma
in subset: oncotree slim

Axiom
annotated source: Papillary Renal Cell Carcinoma
annotated property: definition
annotated target: Also known as chromophil carcinoma, it represents a minority of renal cell carcinomas. It can be hereditary or sporadic. The sporadic papillary renal cell carcinoma is characterized by trisomy of chromosomes 7, 16, and 17, and loss of chromosome Y. The peak incidence is in the sixth and seven decades. It is classified as type 1 or 2, based on the cytoplasmic volume and the thickness of the lining neoplastic cells. The prognosis is more favorable than for conventional (clear cell) renal cell carcinoma. -- 2003
def-source: NCI

Axiom
annotated source: Papillary Renal Cell Carcinoma
annotated property: has exact synonym
annotated target: Chromophil Carcinoma of Kidney
term-group: SY
term-source: NCI

Axiom
annotated source: Papillary Renal Cell Carcinoma
annotated property: has exact synonym
annotated target: Chromophil Carcinoma of the Kidney
term-group: SY
term-source: NCI

Axiom
annotated source: Papillary Renal Cell Carcinoma
annotated property: has exact synonym
annotated target: Chromophil Renal Cell Carcinoma
term-group: SY
term-source: NCI

Axiom
annotated source: Papillary Renal Cell Carcinoma
annotated property: has exact synonym
annotated target: Papillary (Chromophil) Renal Cell Carcinoma
term-group: SY
term-source: NCI

Axiom
annotated source: Papillary Renal Cell Carcinoma
annotated property: has exact synonym
annotated target: Papillary Renal Cell Cancer
term-group: DN
term-source: CTRP

Axiom
annotated source: Papillary Renal Cell Carcinoma
annotated property: has exact synonym
annotated target: Papillary Renal Cell Carcinoma
term-group: PT
term-source: NCI

Axiom
annotated source: Papillary Renal Cell Carcinoma
annotated property: has exact synonym
annotated target: Papillary Renal Cell Carcinoma
term-group: SY
term-source: NCI
source-code: TCGA
subsource-name: caDSR

Axiom
annotated source: Papillary Renal Cell Carcinoma
annotated property: has exact synonym
annotated target: Papillary renal cell carcinoma
term-group: PT
term-source: CTEP
source-code: 10033702
subsource-name: SDC

Basaloid Carcinoma of the Penis
type: Class
definition: An aggressive, human papillomavirus-related squamous cell carcinoma that arises from the penis. It is characterized by the presence of nests of small malignant cells. The malignant cells tend to invade deeply into the adjacent tissues. Comedo-type necrosis is often present.
code: C6980
Semantic_Type: Neoplastic Process
Preferred_Name: Basaloid Carcinoma of the Penis
UMLS_CUI: C1332462
Neoplastic_Status: Malignant
Legacy_Concept_Name: Basaloid_Carcinoma_of_the_Penis
has exact synonym: Basaloid Carcinoma of Penis
has exact synonym: Basaloid Carcinoma of the Penis
has exact synonym: Basaloid Penile Squamous Cell Carcinoma
has exact synonym: Basaloid Squamous Cell Carcinoma of Penis
has exact synonym: Basaloid Squamous Cell Carcinoma of the Penis
has exact synonym: Squamous Cell Carcinoma of Penis, Basaloid Type
has exact synonym: Squamous Cell Carcinoma of the Penis, Basaloid Type
in subset: oncotree slim

Axiom
annotated source: Basaloid Carcinoma of the Penis
annotated property: definition
annotated target: An aggressive, human papillomavirus-related squamous cell carcinoma that arises from the penis. It is characterized by the presence of nests of small malignant cells. The malignant cells tend to invade deeply into the adjacent tissues. Comedo-type necrosis is often present.
def-source: NCI

Axiom
annotated source: Basaloid Carcinoma of the Penis
annotated property: has exact synonym
annotated target: Basaloid Carcinoma of Penis
term-group: SY
term-source: NCI

Axiom
annotated source: Basaloid Carcinoma of the Penis
annotated property: has exact synonym
annotated target: Basaloid Carcinoma of the Penis
term-group: PT
term-source: NCI

Axiom
annotated source: Basaloid Carcinoma of the Penis
annotated property: has exact synonym
annotated target: Basaloid Penile Squamous Cell Carcinoma
term-group: SY
term-source: NCI

Axiom
annotated source: Basaloid Carcinoma of the Penis
annotated property: has exact synonym
annotated target: Basaloid Squamous Cell Carcinoma of Penis
term-group: SY
term-source: NCI

Axiom
annotated source: Basaloid Carcinoma of the Penis
annotated property: has exact synonym
annotated target: Basaloid Squamous Cell Carcinoma of the Penis
term-group: SY
term-source: NCI

Axiom
annotated source: Basaloid Carcinoma of the Penis
annotated property: has exact synonym
annotated target: Squamous Cell Carcinoma of Penis, Basaloid Type
term-group: SY
term-source: NCI

Axiom
annotated source: Basaloid Carcinoma of the Penis
annotated property: has exact synonym
annotated target: Squamous Cell Carcinoma of the Penis, Basaloid Type
term-group: SY
term-source: NCI

Warty Carcinoma of the Penis
type: Class
definition: A squamous cell carcinoma that arises from the penis. It is characterized by a papillary growth pattern, hyperkeratosis and parakeratosis. Koilocytotic atypia is present. Human papillomavirus types 16 and 6 have been identified in some cases.
code: C6981
Semantic_Type: Neoplastic Process
Preferred_Name: Warty Carcinoma of the Penis
UMLS_CUI: C1337009
Neoplastic_Status: Malignant
Legacy_Concept_Name: Warty_Carcinoma_of_the_Penis
has exact synonym: Condylomatous Carcinoma of Penis
has exact synonym: Condylomatous Carcinoma of the Penis
has exact synonym: Condylomatous Penile Squamous Cell Carcinoma
has exact synonym: Condylomatous Squamous Cell Carcinoma of Penis
has exact synonym: Condylomatous Squamous Cell Carcinoma of the Penis
has exact synonym: Squamous Cell Carcinoma of Penis, Condylomatous Type
has exact synonym: Squamous Cell Carcinoma of Penis, Warty Type
has exact synonym: Squamous Cell Carcinoma of the Penis, Condylomatous Type
has exact synonym: Squamous Cell Carcinoma of the Penis, Warty Type
has exact synonym: Warty Carcinoma of Penis
has exact synonym: Warty Carcinoma of the Penis
has exact synonym: Warty Penile Squamous Cell Carcinoma
has exact synonym: Warty Squamous Cell Carcinoma of Penis
has exact synonym: Warty Squamous Cell Carcinoma of the Penis
in subset: oncotree slim

Axiom
annotated source: Warty Carcinoma of the Penis
annotated property: definition
annotated target: A squamous cell carcinoma that arises from the penis. It is characterized by a papillary growth pattern, hyperkeratosis and parakeratosis. Koilocytotic atypia is present. Human papillomavirus types 16 and 6 have been identified in some cases.
def-source: NCI

Axiom
annotated source: Warty Carcinoma of the Penis
annotated property: has exact synonym
annotated target: Condylomatous Carcinoma of Penis
term-group: SY
term-source: NCI

Axiom
annotated source: Warty Carcinoma of the Penis
annotated property: has exact synonym
annotated target: Condylomatous Carcinoma of the Penis
term-group: SY
term-source: NCI

Axiom
annotated source: Warty Carcinoma of the Penis
annotated property: has exact synonym
annotated target: Condylomatous Penile Squamous Cell Carcinoma
term-group: SY
term-source: NCI

Axiom
annotated source: Warty Carcinoma of the Penis
annotated property: has exact synonym
annotated target: Condylomatous Squamous Cell Carcinoma of Penis
term-group: SY
term-source: NCI

Axiom
annotated source: Warty Carcinoma of the Penis
annotated property: has exact synonym
annotated target: Condylomatous Squamous Cell Carcinoma of the Penis
term-group: SY
term-source: NCI

Axiom
annotated source: Warty Carcinoma of the Penis
annotated property: has exact synonym
annotated target: Squamous Cell Carcinoma of Penis, Condylomatous Type
term-group: SY
term-source: NCI

Axiom
annotated source: Warty Carcinoma of the Penis
annotated property: has exact synonym
annotated target: Squamous Cell Carcinoma of Penis, Warty Type
term-group: SY
term-source: NCI

Axiom
annotated source: Warty Carcinoma of the Penis
annotated property: has exact synonym
annotated target: Squamous Cell Carcinoma of the Penis, Condylomatous Type
term-group: SY
term-source: NCI

Axiom
annotated source: Warty Carcinoma of the Penis
annotated property: has exact synonym
annotated target: Squamous Cell Carcinoma of the Penis, Warty Type
term-group: SY
term-source: NCI

Axiom
annotated source: Warty Carcinoma of the Penis
annotated property: has exact synonym
annotated target: Warty Carcinoma of Penis
term-group: SY
term-source: NCI

Axiom
annotated source: Warty Carcinoma of the Penis
annotated property: has exact synonym
annotated target: Warty Carcinoma of the Penis
term-group: PT
term-source: NCI

Axiom
annotated source: Warty Carcinoma of the Penis
annotated property: has exact synonym
annotated target: Warty Penile Squamous Cell Carcinoma
term-group: SY
term-source: NCI

Axiom
annotated source: Warty Carcinoma of the Penis
annotated property: has exact synonym
annotated target: Warty Squamous Cell Carcinoma of Penis
term-group: SY
term-source: NCI

Axiom
annotated source: Warty Carcinoma of the Penis
annotated property: has exact synonym
annotated target: Warty Squamous Cell Carcinoma of the Penis
term-group: SY
term-source: NCI

Verrucous Carcinoma of the Penis
type: Class
definition: A slow growing, locally recurring, very well differentiated papillary squamous cell carcinoma that arises from the penis. It is characterized by the presence of acanthosis and hyperkeratosis. The neoplastic infiltrate extends into the underlying stroma with a pushing border. Koilocytotic atypia is not present.
code: C6982
Semantic_Type: Neoplastic Process
Preferred_Name: Verrucous Carcinoma of the Penis
UMLS_CUI: C1336955
Neoplastic_Status: Malignant
Legacy_Concept_Name: Verrucous_Carcinoma_of_the_Penis
has exact synonym: Squamous Carcinoma of Penis, Verrucous Type
has exact synonym: Squamous Carcinoma of the Penis, Verrucous Type
has exact synonym: Verrucous Carcinoma of Penis
has exact synonym: Verrucous Carcinoma of the Penis
has exact synonym: Verrucous Penile Carcinoma
has exact synonym: Verrucous Penile Squamous Carcinoma
has exact synonym: Verrucous Squamous Carcinoma of Penis
has exact synonym: Verrucous Squamous Carcinoma of the Penis
in subset: oncotree slim

Axiom
annotated source: Verrucous Carcinoma of the Penis
annotated property: definition
annotated target: A slow growing, locally recurring, very well differentiated papillary squamous cell carcinoma that arises from the penis. It is characterized by the presence of acanthosis and hyperkeratosis. The neoplastic infiltrate extends into the underlying stroma with a pushing border. Koilocytotic atypia is not present.
def-source: NCI

Axiom
annotated source: Verrucous Carcinoma of the Penis
annotated property: has exact synonym
annotated target: Squamous Carcinoma of Penis, Verrucous Type
term-group: SY
term-source: NCI

Axiom
annotated source: Verrucous Carcinoma of the Penis
annotated property: has exact synonym
annotated target: Squamous Carcinoma of the Penis, Verrucous Type
term-group: SY
term-source: NCI

Axiom
annotated source: Verrucous Carcinoma of the Penis
annotated property: has exact synonym
annotated target: Verrucous Carcinoma of Penis
term-group: SY
term-source: NCI

Axiom
annotated source: Verrucous Carcinoma of the Penis
annotated property: has exact synonym
annotated target: Verrucous Carcinoma of the Penis
term-group: PT
term-source: NCI

Axiom
annotated source: Verrucous Carcinoma of the Penis
annotated property: has exact synonym
annotated target: Verrucous Penile Carcinoma
term-group: SY
term-source: NCI

Axiom
annotated source: Verrucous Carcinoma of the Penis
annotated property: has exact synonym
annotated target: Verrucous Penile Squamous Carcinoma
term-group: SY
term-source: NCI

Axiom
annotated source: Verrucous Carcinoma of the Penis
annotated property: has exact synonym
annotated target: Verrucous Squamous Carcinoma of Penis
term-group: SY
term-source: NCI

Axiom
annotated source: Verrucous Carcinoma of the Penis
annotated property: has exact synonym
annotated target: Verrucous Squamous Carcinoma of the Penis
term-group: SY
term-source: NCI

Invasive Hydatidiform Mole
type: Class
subclass of: Hydatidiform Mole
definition: A complete hydatidiform mole or very rarely a partial mole that invades the myometrium.
Has_NICHD_Parent: Hydatidiform Mole
Concept_In_Subset: NCIT C116977
Concept_In_Subset: NCIT C118466
Concept_In_Subset: NCIT C90259
code: C6985
Semantic_Type: Disease or Syndrome
Display_Name: Invasive Hydatidiform Mole
Preferred_Name: Invasive Hydatidiform Mole
UMLS_CUI: C0008493
Contributing_Source: CTRP
Contributing_Source: NICHD
ALT_DEFINITION: A complete hydatidiform mole or very rarely a partial mole that invades the myometrium.
ALT_DEFINITION: A type of cancer that grows into the muscular wall of the uterus. It is formed after conception (fertilization of an egg by a sperm). It may spread to other parts of the body, such as the vagina, vulva, and lung.
ICD-O-3_Code: 9100/1
Legacy_Concept_Name: Invasive_Hydatidiform_Mole
NICHD_Hierarchy_Term: Invasive Hydatidiform Mole
has exact synonym: Chorioadenoma
has exact synonym: Chorioadenoma Destruens
has exact synonym: Invasive Gestational Trophoblastic Neoplasm
has exact synonym: Invasive Hydatidiform Mole
has exact synonym: Invasive Mole
has exact synonym: chorioadenoma destruens
has exact synonym: invasive hydatidiform mole
in subset: oncotree slim

Axiom
annotated source: Invasive Hydatidiform Mole
annotated property: definition
annotated target: A complete hydatidiform mole or very rarely a partial mole that invades the myometrium.
def-source: NCI
attr: NICHD

Axiom
annotated source: Invasive Hydatidiform Mole
annotated property: ALT_DEFINITION
annotated target: A complete hydatidiform mole or very rarely a partial mole that invades the myometrium.
def-source: NICHD

Axiom
annotated source: Invasive Hydatidiform Mole
annotated property: ALT_DEFINITION
annotated target: A type of cancer that grows into the muscular wall of the uterus. It is formed after conception (fertilization of an egg by a sperm). It may spread to other parts of the body, such as the vagina, vulva, and lung.
def-source: NCI-GLOSS

Axiom
annotated source: Invasive Hydatidiform Mole
annotated property: has exact synonym
annotated target: Chorioadenoma
term-group: SY
term-source: NCI

Axiom
annotated source: Invasive Hydatidiform Mole
annotated property: has exact synonym
annotated target: Chorioadenoma Destruens
term-group: SY
term-source: NCI

Axiom
annotated source: Invasive Hydatidiform Mole
annotated property: has exact synonym
annotated target: Invasive Gestational Trophoblastic Neoplasm
term-group: SY
term-source: NCI

Axiom
annotated source: Invasive Hydatidiform Mole
annotated property: has exact synonym
annotated target: Invasive Hydatidiform Mole
term-group: PT
term-source: NCI

Axiom
annotated source: Invasive Hydatidiform Mole
annotated property: has exact synonym
annotated target: Invasive Hydatidiform Mole
term-group: PT
term-source: NICHD

Axiom
annotated source: Invasive Hydatidiform Mole
annotated property: has exact synonym
annotated target: Invasive Mole
term-group: SY
term-source: NCI

Axiom
annotated source: Invasive Hydatidiform Mole
annotated property: has exact synonym
annotated target: chorioadenoma destruens
term-group: PT
term-source: NCI-GLOSS
source-code: CDR0000458034

Axiom
annotated source: Invasive Hydatidiform Mole
annotated property: has exact synonym
annotated target: invasive hydatidiform mole
term-group: PT
term-source: NCI-GLOSS
source-code: CDR0000446955

Central Nervous System Mature Teratoma
type: Class
subclass of: NCIT C9015
definition: A teratoma composed exclusively of fully differentiated, 'adult-type' tissue elements that are sometimes arranged in a pattern resembling normal tissue relationships. Mitotic activity is low or absent. The more common ectodermal components present in a mature teratoma include skin, brain and choroid plexus. The more common mesodermal components include cartilage, bone, fat and muscle (both smooth and striated). And the most common endodermal components are cysts lined by epithelia of respiratory or enteric type and in some cases pancreatic or hepatic tissue. (Adapted from WHO)
code: C7013
Semantic_Type: Neoplastic Process
Preferred_Name: Central Nervous System Mature Teratoma
UMLS_CUI: C1332886
Neoplastic_Status: Benign
Legacy_Concept_Name: Central_Nervous_System_Mature_Teratoma
has exact synonym: CNS Mature Teratoma
has exact synonym: Central Nervous System Mature Teratoma
has exact synonym: Mature Teratoma of CNS
has exact synonym: Mature Teratoma of Central Nervous System
has exact synonym: Mature Teratoma of the CNS
has exact synonym: Mature Teratoma of the Central Nervous System
in subset: oncotree slim

Axiom
annotated source: Central Nervous System Mature Teratoma
annotated property: definition
annotated target: A teratoma composed exclusively of fully differentiated, 'adult-type' tissue elements that are sometimes arranged in a pattern resembling normal tissue relationships. Mitotic activity is low or absent. The more common ectodermal components present in a mature teratoma include skin, brain and choroid plexus. The more common mesodermal components include cartilage, bone, fat and muscle (both smooth and striated). And the most common endodermal components are cysts lined by epithelia of respiratory or enteric type and in some cases pancreatic or hepatic tissue. (Adapted from WHO)
def-source: NCI

Axiom
annotated source: Central Nervous System Mature Teratoma
annotated property: has exact synonym
annotated target: CNS Mature Teratoma
term-group: SY
term-source: NCI

Axiom
annotated source: Central Nervous System Mature Teratoma
annotated property: has exact synonym
annotated target: Central Nervous System Mature Teratoma
term-group: PT
term-source: NCI

Axiom
annotated source: Central Nervous System Mature Teratoma
annotated property: has exact synonym
annotated target: Mature Teratoma of CNS
term-group: SY
term-source: NCI

Axiom
annotated source: Central Nervous System Mature Teratoma
annotated property: has exact synonym
annotated target: Mature Teratoma of Central Nervous System
term-group: SY
term-source: NCI

Axiom
annotated source: Central Nervous System Mature Teratoma
annotated property: has exact synonym
annotated target: Mature Teratoma of the CNS
term-group: SY
term-source: NCI

Axiom
annotated source: Central Nervous System Mature Teratoma
annotated property: has exact synonym
annotated target: Mature Teratoma of the Central Nervous System
term-group: SY
term-source: NCI

Central Nervous System Teratoma with Malignant Transformation
type: Class
definition: A central nervous system teratoma characterized by the presence of a malignant component. The malignant component most often is sarcomatous (rhabdomyosarcoma or undifferentiated sarcoma) or carcinomatous (squamous cell carcinoma or adenocarcinoma).
code: C7015
Semantic_Type: Neoplastic Process
Preferred_Name: Central Nervous System Teratoma with Malignant Transformation
UMLS_CUI: C1336704
Neoplastic_Status: Malignant
Legacy_Concept_Name: Teratoma_of_the_CNS_with_Malignant_Transformation
has exact synonym: CNS Teratoma with Malignant Transformation
has exact synonym: Central Nervous System Teratoma with Malignant Transformation
has exact synonym: Teratoma of CNS with Malignant Transformation
has exact synonym: Teratoma of Central Nervous System with Malignant Transformation
has exact synonym: Teratoma of the CNS with Malignant Transformation
has exact synonym: Teratoma of the Central Nervous System with Malignant Transformation
in subset: oncotree slim

Axiom
annotated source: Central Nervous System Teratoma with Malignant Transformation
annotated property: definition
annotated target: A central nervous system teratoma characterized by the presence of a malignant component. The malignant component most often is sarcomatous (rhabdomyosarcoma or undifferentiated sarcoma) or carcinomatous (squamous cell carcinoma or adenocarcinoma).
def-source: NCI

Axiom
annotated source: Central Nervous System Teratoma with Malignant Transformation
annotated property: has exact synonym
annotated target: CNS Teratoma with Malignant Transformation
term-group: SY
term-source: NCI

Axiom
annotated source: Central Nervous System Teratoma with Malignant Transformation
annotated property: has exact synonym
annotated target: Central Nervous System Teratoma with Malignant Transformation
term-group: PT
term-source: NCI

Axiom
annotated source: Central Nervous System Teratoma with Malignant Transformation
annotated property: has exact synonym
annotated target: Teratoma of CNS with Malignant Transformation
term-group: SY
term-source: NCI

Axiom
annotated source: Central Nervous System Teratoma with Malignant Transformation
annotated property: has exact synonym
annotated target: Teratoma of Central Nervous System with Malignant Transformation
term-group: SY
term-source: NCI

Axiom
annotated source: Central Nervous System Teratoma with Malignant Transformation
annotated property: has exact synonym
annotated target: Teratoma of the CNS with Malignant Transformation
term-group: SY
term-source: NCI

Axiom
annotated source: Central Nervous System Teratoma with Malignant Transformation
annotated property: has exact synonym
annotated target: Teratoma of the Central Nervous System with Malignant Transformation
term-group: SY
term-source: NCI

Myofibroma
type: Class
definition: A benign, localized, nodular and well-circumscribed neoplasm usually seen as a congenital neoplasm or in the first year of life. It is characterized by a biphasic growth pattern and is composed of small, undifferentiated mesenchymal cells associated with branching thin-walled vessels and more mature neoplastic spindle cells with abundant eosinophilic cytoplasm in a collagenous stroma.
code: C7052
Semantic_Type: Neoplastic Process
Preferred_Name: Myofibroma
UMLS_CUI: C1266121
ICD-O-3_Code: 8824/0
Neoplastic_Status: Benign
Legacy_Concept_Name: Solitary_Myofibromatosis
has exact synonym: Infantile Hemangiopericytoma
has exact synonym: Myofibroma
in subset: oncotree slim

Axiom
annotated source: Myofibroma
annotated property: definition
annotated target: A benign, localized, nodular and well-circumscribed neoplasm usually seen as a congenital neoplasm or in the first year of life. It is characterized by a biphasic growth pattern and is composed of small, undifferentiated mesenchymal cells associated with branching thin-walled vessels and more mature neoplastic spindle cells with abundant eosinophilic cytoplasm in a collagenous stroma.
def-source: NCI

Axiom
annotated source: Myofibroma
annotated property: has exact synonym
annotated target: Infantile Hemangiopericytoma
term-group: AQS
term-source: NCI

Axiom
annotated source: Myofibroma
annotated property: has exact synonym
annotated target: Myofibroma
term-group: PT
term-source: NCI

Classical Hodgkin Lymphoma
type: Class
subclass of: NCIT C9357
definition: A monoclonal B-cell lymphoproliferation in the vast majority of cases. It is characterized by a bimodal age distribution (15-30 years of life and late life). Epstein-Barr virus has been postulated to play a role in the pathogenesis of classical Hodgkin lymphoma. Morphologically, it is characterized by the presence of Reed-Sternberg cells and mononuclear Hodgkin cells. The Reed-Sternberg and mononuclear Hodgkin cells are CD30 positive in nearly all cases and CD15 positive in the majority of cases. Four histologic subtypes have been distinguished: lymphocyte-rich, nodular sclerosis, mixed cellularity, and lymphocyte-depleted classical Hodgkin lymphoma.
Concept_In_Subset: NCIT C126659
code: C7164
Semantic_Type: Neoplastic Process
Preferred_Name: Classical Hodgkin Lymphoma
UMLS_CUI: C1333064
ALT_DEFINITION: The most common type of Hodgkin lymphoma, which is a cancer of the immune system. Classical Hodgkin lymphoma is marked by the presence of a type of cell called the Reed-Sternberg cell.
Neoplastic_Status: Malignant
Legacy_Concept_Name: Classical_Hodgkin_s_Lymphoma
has exact synonym: CHL
has exact synonym: Classical Hodgkin Lymphoma
has exact synonym: Classical Hodgkin's Lymphoma
has exact synonym: cHL
has exact synonym: classical Hodgkin lymphoma
in subset: oncotree slim

Axiom
annotated source: Classical Hodgkin Lymphoma
annotated property: definition
annotated target: A monoclonal B-cell lymphoproliferation in the vast majority of cases. It is characterized by a bimodal age distribution (15-30 years of life and late life). Epstein-Barr virus has been postulated to play a role in the pathogenesis of classical Hodgkin lymphoma. Morphologically, it is characterized by the presence of Reed-Sternberg cells and mononuclear Hodgkin cells. The Reed-Sternberg and mononuclear Hodgkin cells are CD30 positive in nearly all cases and CD15 positive in the majority of cases. Four histologic subtypes have been distinguished: lymphocyte-rich, nodular sclerosis, mixed cellularity, and lymphocyte-depleted classical Hodgkin lymphoma.
def-source: NCI

Axiom
annotated source: Classical Hodgkin Lymphoma
annotated property: ALT_DEFINITION
annotated target: The most common type of Hodgkin lymphoma, which is a cancer of the immune system. Classical Hodgkin lymphoma is marked by the presence of a type of cell called the Reed-Sternberg cell.
def-source: NCI-GLOSS

Axiom
annotated source: Classical Hodgkin Lymphoma
annotated property: has exact synonym
annotated target: CHL
term-group: AB
term-source: NCI

Axiom
annotated source: Classical Hodgkin Lymphoma
annotated property: has exact synonym
annotated target: Classical Hodgkin Lymphoma
term-group: DN
term-source: CTRP

Axiom
annotated source: Classical Hodgkin Lymphoma
annotated property: has exact synonym
annotated target: Classical Hodgkin Lymphoma
term-group: PT
term-source: NCI

Axiom
annotated source: Classical Hodgkin Lymphoma
annotated property: has exact synonym
annotated target: Classical Hodgkin Lymphoma
term-group: SY
term-source: NCI
source-code: TCGA
subsource-name: caDSR

Axiom
annotated source: Classical Hodgkin Lymphoma
annotated property: has exact synonym
annotated target: Classical Hodgkin's Lymphoma
term-group: SY
term-source: NCI

Axiom
annotated source: Classical Hodgkin Lymphoma
annotated property: has exact synonym
annotated target: cHL
term-group: AB
term-source: NCI

Axiom
annotated source: Classical Hodgkin Lymphoma
annotated property: has exact synonym
annotated target: classical Hodgkin lymphoma
term-group: PT
term-source: NCI-GLOSS
source-code: CDR0000574284

Central Nervous System Neuroepithelial Neoplasm of Uncertain Origin
type: Class
code: C7172
Semantic_Type: Neoplastic Process
Preferred_Name: Central Nervous System Neuroepithelial Neoplasm of Uncertain Origin
UMLS_CUI: C1332889
Neoplastic_Status: Undetermined
Legacy_Concept_Name: Central_Nervous_System_Neuroepithelial_Neoplasm_of_Uncertain_Origin
has exact synonym: Central Nervous System Neuroepithelial Neoplasm of Uncertain Origin
in subset: oncotree slim

Axiom
annotated source: Central Nervous System Neuroepithelial Neoplasm of Uncertain Origin
annotated property: has exact synonym
annotated target: Central Nervous System Neuroepithelial Neoplasm of Uncertain Origin
term-group: AQ
term-source: NCI

Blastic Plasmacytoid Dendritic Cell Neoplasm
type: Class
definition: An aggressive immature hematologic neoplasm formerly known as blastic NK cell lymphoma, composed of cells with a lymphoblast-like morphology. Recent evidence suggests derivation from a plasmacytoid monocyte. Patients present with cutaneous tumors and bone marrow involvement.
Concept_In_Subset: NCIT C116977
Concept_In_Subset: NCIT C126659
code: C7203
Semantic_Type: Neoplastic Process
Display_Name: Blastic Plasmacytoid Dendritic Cell Neoplasm
Preferred_Name: Blastic Plasmacytoid Dendritic Cell Neoplasm
UMLS_CUI: C1301363
Contributing_Source: CTRP
ICD-O-3_Code: 9727/3
Neoplastic_Status: Malignant
Legacy_Concept_Name: Blastic_NK-Cell_Lymphoma
has exact synonym: Agranular CD4+ CD56+ Hematodermic Neoplasm/Tumor
has exact synonym: Agranular CD4+ Natural Killer Cell Leukemia
has exact synonym: Blastic NK-Cell Lymphoma
has exact synonym: Blastic Natural Killer Leukemia/Lymphoma
has exact synonym: Blastic Plasmacytoid Dendritic Cell Neoplasm
has exact synonym: CD4+/CD56+ Hematodermic Neoplasm
has exact synonym: Early Plasmacytoid Dendritic Cell Leukemia/Lymphoma
has exact synonym: Monomorphic NK-Cell Lymphoma
has exact synonym: Primary Cutaneous CD4+/CD56+ Hematolymphoid Neoplasm
in subset: oncotree slim

Axiom
annotated source: Blastic Plasmacytoid Dendritic Cell Neoplasm
annotated property: definition
annotated target: An aggressive immature hematologic neoplasm formerly known as blastic NK cell lymphoma, composed of cells with a lymphoblast-like morphology. Recent evidence suggests derivation from a plasmacytoid monocyte. Patients present with cutaneous tumors and bone marrow involvement.
def-source: NCI

Axiom
annotated source: Blastic Plasmacytoid Dendritic Cell Neoplasm
annotated property: has exact synonym
annotated target: Agranular CD4+ CD56+ Hematodermic Neoplasm/Tumor
term-group: SY
term-source: NCI

Axiom
annotated source: Blastic Plasmacytoid Dendritic Cell Neoplasm
annotated property: has exact synonym
annotated target: Agranular CD4+ Natural Killer Cell Leukemia
term-group: SY
term-source: NCI

Axiom
annotated source: Blastic Plasmacytoid Dendritic Cell Neoplasm
annotated property: has exact synonym
annotated target: Blastic NK-Cell Lymphoma
term-group: SY
term-source: NCI

Axiom
annotated source: Blastic Plasmacytoid Dendritic Cell Neoplasm
annotated property: has exact synonym
annotated target: Blastic Natural Killer Leukemia/Lymphoma
term-group: SY
term-source: NCI

Axiom
annotated source: Blastic Plasmacytoid Dendritic Cell Neoplasm
annotated property: has exact synonym
annotated target: Blastic Plasmacytoid Dendritic Cell Neoplasm
term-group: PT
term-source: NCI

Axiom
annotated source: Blastic Plasmacytoid Dendritic Cell Neoplasm
annotated property: has exact synonym
annotated target: Blastic Plasmacytoid Dendritic Cell Neoplasm
term-group: SY
term-source: NCI
source-code: TCGA
subsource-name: caDSR

Axiom
annotated source: Blastic Plasmacytoid Dendritic Cell Neoplasm
annotated property: has exact synonym
annotated target: CD4+/CD56+ Hematodermic Neoplasm
term-group: SY
term-source: NCI

Axiom
annotated source: Blastic Plasmacytoid Dendritic Cell Neoplasm
annotated property: has exact synonym
annotated target: Early Plasmacytoid Dendritic Cell Leukemia/Lymphoma
term-group: SY
term-source: NCI

Axiom
annotated source: Blastic Plasmacytoid Dendritic Cell Neoplasm
annotated property: has exact synonym
annotated target: Monomorphic NK-Cell Lymphoma
term-group: SY
term-source: NCI

Axiom
annotated source: Blastic Plasmacytoid Dendritic Cell Neoplasm
annotated property: has exact synonym
annotated target: Primary Cutaneous CD4+/CD56+ Hematolymphoid Neoplasm
term-group: SY
term-source: NCI

Nodular Lymphocyte Predominant Hodgkin Lymphoma
type: Class
subclass of: NCIT C9357
definition: A monoclonal B-cell neoplasm characterized by a nodular, or a nodular and diffuse proliferation of scattered large neoplastic cells known as popcorn or lymphocyte predominant cells (LP cells)- formerly called L&H cells for lymphocytic and/or histiocytic Reed-Sternberg cell variants. The LP cells lack CD15 and CD30 in nearly all instances. Patients are predominantly male, frequently in the 30-50 year age group. Most patients present with limited stage disease (localized peripheral lymphadenopathy, stage I or II). (WHO 2008)
Concept_In_Subset: NCIT C102905
Concept_In_Subset: NCIT C103135
Concept_In_Subset: NCIT C126659
code: C7258
Semantic_Type: Neoplastic Process
Preferred_Name: Nodular Lymphocyte Predominant Hodgkin Lymphoma
UMLS_CUI: C1334968
Contributing_Source: CTEP
ALT_DEFINITION: A rare type of Hodgkin lymphoma, which is a cancer of the immune system. It is marked by the presence of a type of cell called a popcorn cell, which is different from the typical Reed-Sternberg cell found in classical Hodgkin lymphoma. This type of Hodgkin lymphoma may change into diffuse large B-cell lymphoma.
ICD-O-3_Code: 9659/3
Neoplastic_Status: Malignant
Legacy_Concept_Name: Nodular_Lymphocyte_Predominant_Hodgkin_s_Lymphoma
has exact synonym: Hodgkin lymphoma nodular LP, NOS
has exact synonym: Hodgkin lymphoma nodular lymphocyte predominant type, NOS
has exact synonym: NLPHL
has exact synonym: Nodular Lymphocyte Predominant Hodgkin Lymphoma
has exact synonym: Nodular Lymphocyte Predominant Hodgkin's Lymphoma
has exact synonym: nodular lymphocyte-predominant Hodgkin lymphoma
in subset: oncotree slim

Axiom
annotated source: Nodular Lymphocyte Predominant Hodgkin Lymphoma
annotated property: definition
annotated target: A monoclonal B-cell neoplasm characterized by a nodular, or a nodular and diffuse proliferation of scattered large neoplastic cells known as popcorn or lymphocyte predominant cells (LP cells)- formerly called L&H cells for lymphocytic and/or histiocytic Reed-Sternberg cell variants. The LP cells lack CD15 and CD30 in nearly all instances. Patients are predominantly male, frequently in the 30-50 year age group. Most patients present with limited stage disease (localized peripheral lymphadenopathy, stage I or II). (WHO 2008)
def-source: NCI

Axiom
annotated source: Nodular Lymphocyte Predominant Hodgkin Lymphoma
annotated property: ALT_DEFINITION
annotated target: A rare type of Hodgkin lymphoma, which is a cancer of the immune system. It is marked by the presence of a type of cell called a popcorn cell, which is different from the typical Reed-Sternberg cell found in classical Hodgkin lymphoma. This type of Hodgkin lymphoma may change into diffuse large B-cell lymphoma.
def-source: NCI-GLOSS

Axiom
annotated source: Nodular Lymphocyte Predominant Hodgkin Lymphoma
annotated property: has exact synonym
annotated target: Hodgkin lymphoma nodular LP, NOS
term-group: SY
term-source: CTEP
source-code: 10020231
subsource-name: SDC

Axiom
annotated source: Nodular Lymphocyte Predominant Hodgkin Lymphoma
annotated property: has exact synonym
annotated target: Hodgkin lymphoma nodular lymphocyte predominant type, NOS
term-group: PT
term-source: CTEP
source-code: 10020231
subsource-name: SDC

Axiom
annotated source: Nodular Lymphocyte Predominant Hodgkin Lymphoma
annotated property: has exact synonym
annotated target: NLPHL
term-group: AB
term-source: NCI

Axiom
annotated source: Nodular Lymphocyte Predominant Hodgkin Lymphoma
annotated property: has exact synonym
annotated target: NLPHL
term-group: PT
term-source: NCI-GLOSS
source-code: CDR0000574285

Axiom
annotated source: Nodular Lymphocyte Predominant Hodgkin Lymphoma
annotated property: has exact synonym
annotated target: Nodular Lymphocyte Predominant Hodgkin Lymphoma
term-group: DN
term-source: CTRP

Axiom
annotated source: Nodular Lymphocyte Predominant Hodgkin Lymphoma
annotated property: has exact synonym
annotated target: Nodular Lymphocyte Predominant Hodgkin Lymphoma
term-group: PT
term-source: NCI

Axiom
annotated source: Nodular Lymphocyte Predominant Hodgkin Lymphoma
annotated property: has exact synonym
annotated target: Nodular Lymphocyte Predominant Hodgkin Lymphoma
term-group: SY
term-source: NCI
source-code: TCGA
subsource-name: caDSR

Axiom
annotated source: Nodular Lymphocyte Predominant Hodgkin Lymphoma
annotated property: has exact synonym
annotated target: Nodular Lymphocyte Predominant Hodgkin's Lymphoma
term-group: SY
term-source: NCI

Axiom
annotated source: Nodular Lymphocyte Predominant Hodgkin Lymphoma
annotated property: has exact synonym
annotated target: nodular lymphocyte-predominant Hodgkin lymphoma
term-group: PT
term-source: NCI-GLOSS
source-code: CDR0000574286

Basaloid Large Cell Lung Carcinoma
type: Class
subclass of: Large Cell Lung Carcinoma
definition: A morphologic variant of large cell lung carcinoma characterized by the presence of a solid nodular or anastomotic trabecular growth pattern, peripheral palisading, and comedo type necrosis.
Concept_In_Subset: NCIT C126659
code: C7266
Semantic_Type: Neoplastic Process
Preferred_Name: Basaloid Large Cell Lung Carcinoma
UMLS_CUI: C1332463
Neoplastic_Status: Malignant
Legacy_Concept_Name: Basaloid_Lung_Carcinoma
has exact synonym: Basaloid Large Cell Lung Carcinoma
in subset: oncotree slim

Axiom
annotated source: Basaloid Large Cell Lung Carcinoma
annotated property: definition
annotated target: A morphologic variant of large cell lung carcinoma characterized by the presence of a solid nodular or anastomotic trabecular growth pattern, peripheral palisading, and comedo type necrosis.
def-source: NCI

Axiom
annotated source: Basaloid Large Cell Lung Carcinoma
annotated property: has exact synonym
annotated target: Basaloid Large Cell Lung Carcinoma
term-group: PT
term-source: NCI

Hairy Cell Leukemia
type: Class
definition: A neoplasm of small B-lymphocytes with "hairy" projections in bone marrow, spleen, and peripheral blood. Most patients present with splenomegaly and pancytopenia. (WHO, 2001)
Concept_In_Subset: NCIT C102905
Concept_In_Subset: NCIT C103125
Concept_In_Subset: NCIT C116977
Concept_In_Subset: NCIT C126659
code: C7402
Semantic_Type: Neoplastic Process
Display_Name: Hairy Cell Leukemia
Preferred_Name: Hairy Cell Leukemia
UMLS_CUI: C0023443
Contributing_Source: CTEP
Contributing_Source: CTRP
ALT_DEFINITION: A rare type of leukemia in which abnormal B-lymphocytes (a type of white blood cell) are present in the bone marrow, spleen, and peripheral blood. When viewed under a microscope, these cells appear to be covered with tiny hair-like projections.
ICD-O-3_Code: 9940/3
Neoplastic_Status: Malignant
Legacy_Concept_Name: Hairy_Cell_Leukemia
has exact synonym: HCL
has exact synonym: Hairy Cell Leukemia
has exact synonym: Hairy cell leukemia
has exact synonym: Leukemic Reticuloendotheliosis
has exact synonym: hairy cell leukemia
in subset: oncotree slim

Axiom
annotated source: Hairy Cell Leukemia
annotated property: definition
annotated target: A neoplasm of small B-lymphocytes with "hairy" projections in bone marrow, spleen, and peripheral blood. Most patients present with splenomegaly and pancytopenia. (WHO, 2001)
def-source: NCI

Axiom
annotated source: Hairy Cell Leukemia
annotated property: ALT_DEFINITION
annotated target: A rare type of leukemia in which abnormal B-lymphocytes (a type of white blood cell) are present in the bone marrow, spleen, and peripheral blood. When viewed under a microscope, these cells appear to be covered with tiny hair-like projections.
def-source: NCI-GLOSS

Axiom
annotated source: Hairy Cell Leukemia
annotated property: has exact synonym
annotated target: HCL
term-group: AB
term-source: NCI

Axiom
annotated source: Hairy Cell Leukemia
annotated property: has exact synonym
annotated target: Hairy Cell Leukemia
term-group: PT
term-source: NCI

Axiom
annotated source: Hairy Cell Leukemia
annotated property: has exact synonym
annotated target: Hairy Cell Leukemia
term-group: SY
term-source: NCI
source-code: TCGA
subsource-name: caDSR

Axiom
annotated source: Hairy Cell Leukemia
annotated property: has exact synonym
annotated target: Hairy cell leukemia
term-group: PT
term-source: CTEP
source-code: 10019053
subsource-name: SDC

Axiom
annotated source: Hairy Cell Leukemia
annotated property: has exact synonym
annotated target: Leukemic Reticuloendotheliosis
term-group: SY
term-source: NCI

Axiom
annotated source: Hairy Cell Leukemia
annotated property: has exact synonym
annotated target: hairy cell leukemia
term-group: PT
term-source: NCI-GLOSS
source-code: CDR0000045159

Angioimmunoblastic T-Cell Lymphoma
type: Class
definition: A mature T-cell non-Hodgkin lymphoma, characterized by systemic disease and a polymorphous infiltrate involving lymph nodes and extranodal sites. The clinical course is typically aggressive.
Concept_In_Subset: NCIT C116977
Concept_In_Subset: NCIT C126659
code: C7528
Semantic_Type: Neoplastic Process
Display_Name: Angioimmunoblastic T-Cell Lymphoma
Preferred_Name: Angioimmunoblastic T-Cell Lymphoma
UMLS_CUI: C0020981
Contributing_Source: CTRP
ALT_DEFINITION: An aggressive (fast-growing) type of T-cell non-Hodgkin lymphoma marked by enlarged lymph nodes and hypergammaglobulinemia (increased antibodies in the blood). Other symptoms may include a skin rash, fever, weight loss, or night sweats.
ICD-O-3_Code: 9705/3
ICD-O-3_Code: 9767/1
Neoplastic_Status: Malignant
Legacy_Concept_Name: Angioimmunoblastic_T-Cell_Lymphoma
has exact synonym: AILD
has exact synonym: AILT
has exact synonym: Angioimmunoblastic Lymphadenopathy
has exact synonym: Angioimmunoblastic Lymphadenopathy Type T-Cell Lymphoma
has exact synonym: Angioimmunoblastic Lymphadenopathy with Dysproteinemia
has exact synonym: Angioimmunoblastic T-Cell Lymphoma
has exact synonym: angioimmunoblastic T-cell lymphoma
in subset: oncotree slim

Axiom
annotated source: Angioimmunoblastic T-Cell Lymphoma
annotated property: definition
annotated target: A mature T-cell non-Hodgkin lymphoma, characterized by systemic disease and a polymorphous infiltrate involving lymph nodes and extranodal sites. The clinical course is typically aggressive.
def-source: NCI

Axiom
annotated source: Angioimmunoblastic T-Cell Lymphoma
annotated property: ALT_DEFINITION
annotated target: An aggressive (fast-growing) type of T-cell non-Hodgkin lymphoma marked by enlarged lymph nodes and hypergammaglobulinemia (increased antibodies in the blood). Other symptoms may include a skin rash, fever, weight loss, or night sweats.
def-source: NCI-GLOSS

Axiom
annotated source: Angioimmunoblastic T-Cell Lymphoma
annotated property: has exact synonym
annotated target: AILD
term-group: AB
term-source: NCI

Axiom
annotated source: Angioimmunoblastic T-Cell Lymphoma
annotated property: has exact synonym
annotated target: AILT
term-group: AB
term-source: NCI

Axiom
annotated source: Angioimmunoblastic T-Cell Lymphoma
annotated property: has exact synonym
annotated target: Angioimmunoblastic Lymphadenopathy
term-group: AQS
term-source: NCI

Axiom
annotated source: Angioimmunoblastic T-Cell Lymphoma
annotated property: has exact synonym
annotated target: Angioimmunoblastic Lymphadenopathy Type T-Cell Lymphoma
term-group: SY
term-source: NCI

Axiom
annotated source: Angioimmunoblastic T-Cell Lymphoma
annotated property: has exact synonym
annotated target: Angioimmunoblastic Lymphadenopathy with Dysproteinemia
term-group: AQS
term-source: NCI

Axiom
annotated source: Angioimmunoblastic T-Cell Lymphoma
annotated property: has exact synonym
annotated target: Angioimmunoblastic T-Cell Lymphoma
term-group: DN
term-source: CTRP

Axiom
annotated source: Angioimmunoblastic T-Cell Lymphoma
annotated property: has exact synonym
annotated target: Angioimmunoblastic T-Cell Lymphoma
term-group: PT
term-source: NCI

Axiom
annotated source: Angioimmunoblastic T-Cell Lymphoma
annotated property: has exact synonym
annotated target: Angioimmunoblastic T-Cell Lymphoma
term-group: SY
term-source: NCI
source-code: TCGA
subsource-name: caDSR

Axiom
annotated source: Angioimmunoblastic T-Cell Lymphoma
annotated property: has exact synonym
annotated target: angioimmunoblastic T-cell lymphoma
term-group: PT
term-source: NCI-GLOSS
source-code: CDR0000346464

Small Lymphocytic Lymphoma
type: Class
definition: A non-Hodgkin lymphoma composed of monomorphic small, round B-lymphocytes in the lymph nodes. When the lymphoid process predominantly involves the bone marrow and the peripheral blood it is called chronic lymphocytic leukemia. (WHO, 2001)
Concept_In_Subset: NCIT C102905
Concept_In_Subset: NCIT C103133
Concept_In_Subset: NCIT C116977
Concept_In_Subset: NCIT C126659
Concept_In_Subset: NCIT C61410
Concept_In_Subset: NCIT C77526
Concept_In_Subset: NCIT C88025
code: C7540
Semantic_Type: Neoplastic Process
Display_Name: Small Lymphocytic Lymphoma
Preferred_Name: Small Lymphocytic Lymphoma
UMLS_CUI: C0855095
Contributing_Source: CDISC
Contributing_Source: CTEP
Contributing_Source: CTRP
ALT_DEFINITION: A malignant neoplasm composed of small lymphocytes.
ALT_DEFINITION: An indolent (slow-growing) type of lymphoma in which too many immature lymphocytes (white blood cells) are found mostly in the lymph nodes. This causes the lymph nodes to become larger than normal. Sometimes cancer cells are found in the blood and bone marrow, and the disease is called chronic lymphocytic leukemia. The disease is most often seen in people older than 50 years. SLL is a type of non-Hodgkin Lymphoma.
ICD-O-3_Code: 9670/3
Neoplastic_Status: Malignant
Legacy_Concept_Name: Small_Lymphocytic_Lymphoma
has exact synonym: B-Cell Small Lymphocytic Lymphoma
has exact synonym: Diffuse Well Differentiated Lymphocytic Lymphoma
has exact synonym: LYMPHOMA, SMALL LYMPHOCYTIC, MALIGNANT
has exact synonym: Lymphoma, Lymphocytic, Malignant
has exact synonym: SLL
has exact synonym: Small B-Cell Lymphocytic Lymphoma
has exact synonym: Small Lymphocytic Lymphoma
has exact synonym: Small lymphocytic lymphoma, NOS
has exact synonym: small lymphocytic lymphoma
has exact synonym: well-differentiated lymphocytic lymphoma
in subset: oncotree slim

Axiom
annotated source: Small Lymphocytic Lymphoma
annotated property: definition
annotated target: A non-Hodgkin lymphoma composed of monomorphic small, round B-lymphocytes in the lymph nodes. When the lymphoid process predominantly involves the bone marrow and the peripheral blood it is called chronic lymphocytic leukemia. (WHO, 2001)
def-source: NCI

Axiom
annotated source: Small Lymphocytic Lymphoma
annotated property: ALT_DEFINITION
annotated target: A malignant neoplasm composed of small lymphocytes.
def-source: CDISC

Axiom
annotated source: Small Lymphocytic Lymphoma
annotated property: ALT_DEFINITION
annotated target: An indolent (slow-growing) type of lymphoma in which too many immature lymphocytes (white blood cells) are found mostly in the lymph nodes. This causes the lymph nodes to become larger than normal. Sometimes cancer cells are found in the blood and bone marrow, and the disease is called chronic lymphocytic leukemia. The disease is most often seen in people older than 50 years. SLL is a type of non-Hodgkin Lymphoma.
def-source: NCI-GLOSS

Axiom
annotated source: Small Lymphocytic Lymphoma
annotated property: has exact synonym
annotated target: B-Cell Small Lymphocytic Lymphoma
term-group: SY
term-source: CDISC

Axiom
annotated source: Small Lymphocytic Lymphoma
annotated property: has exact synonym
annotated target: B-Cell Small Lymphocytic Lymphoma
term-group: SY
term-source: NCI

Axiom
annotated source: Small Lymphocytic Lymphoma
annotated property: has exact synonym
annotated target: Diffuse Well Differentiated Lymphocytic Lymphoma
term-group: AQS
term-source: NCI

Axiom
annotated source: Small Lymphocytic Lymphoma
annotated property: has exact synonym
annotated target: LYMPHOMA, SMALL LYMPHOCYTIC, MALIGNANT
term-group: PT
term-source: CDISC

Axiom
annotated source: Small Lymphocytic Lymphoma
annotated property: has exact synonym
annotated target: Lymphoma, Lymphocytic, Malignant
term-group: SY
term-source: CDISC

Axiom
annotated source: Small Lymphocytic Lymphoma
annotated property: has exact synonym
annotated target: SLL
term-group: AB
term-source: NCI

Axiom
annotated source: Small Lymphocytic Lymphoma
annotated property: has exact synonym
annotated target: SLL
term-group: PT
term-source: NCI-GLOSS
source-code: CDR0000641299

Axiom
annotated source: Small Lymphocytic Lymphoma
annotated property: has exact synonym
annotated target: SLL
term-group: SY
term-source: CDISC

Axiom
annotated source: Small Lymphocytic Lymphoma
annotated property: has exact synonym
annotated target: Small B-Cell Lymphocytic Lymphoma
term-group: SY
term-source: CDISC

Axiom
annotated source: Small Lymphocytic Lymphoma
annotated property: has exact synonym
annotated target: Small B-Cell Lymphocytic Lymphoma
term-group: SY
term-source: NCI

Axiom
annotated source: Small Lymphocytic Lymphoma
annotated property: has exact synonym
annotated target: Small Lymphocytic Lymphoma
term-group: DN
term-source: CTRP

Axiom
annotated source: Small Lymphocytic Lymphoma
annotated property: has exact synonym
annotated target: Small Lymphocytic Lymphoma
term-group: PT
term-source: NCI

Axiom
annotated source: Small Lymphocytic Lymphoma
annotated property: has exact synonym
annotated target: Small lymphocytic lymphoma, NOS
term-group: PT
term-source: CTEP
source-code: 10003910
subsource-name: SDC

Axiom
annotated source: Small Lymphocytic Lymphoma
annotated property: has exact synonym
annotated target: small lymphocytic lymphoma
term-group: PT
term-source: NCI-GLOSS
source-code: CDR0000407751

Axiom
annotated source: Small Lymphocytic Lymphoma
annotated property: has exact synonym
annotated target: well-differentiated lymphocytic lymphoma
term-group: PT
term-source: NCI-GLOSS
source-code: CDR0000415910

Retinoblastoma
type: Class
definition: A malignant tumor that originates in the nuclear layer of the retina. As the most common primary tumor of the eye in children, retinoblastoma is still relatively uncommon, accounting for only 1% of all malignant tumors in pediatric patients. Approximately 95% of cases are diagnosed before age 5. These tumors may be multifocal, bilateral, congenital, inherited, or acquired. Seventy-five percent of retinoblastomas are unilateral; 60% occur sporadically. A predisposition to retinoblastoma has been associated with 13q14 cytogenetic abnormalities. Patients with the inherited form also appear to be at increased risk for secondary nonocular malignancies such as osteosarcoma, malignant fibrous histiocytoma, and fibrosarcoma.
Has_NICHD_Parent: NCIT C9305
Concept_In_Subset: NCIT C102905
Concept_In_Subset: NCIT C103061
Concept_In_Subset: NCIT C116977
Concept_In_Subset: NCIT C118464
Concept_In_Subset: NCIT C126659
Concept_In_Subset: NCIT C132009
Concept_In_Subset: NCIT C61410
Concept_In_Subset: NCIT C77526
Concept_In_Subset: NCIT C88025
Concept_In_Subset: NCIT C90259
Concept_In_Subset: NCIT C99147
code: C7541
Semantic_Type: Neoplastic Process
Display_Name: Retinoblastoma
Preferred_Name: Retinoblastoma
UMLS_CUI: C0035335
Contributing_Source: CDISC
Contributing_Source: CTEP
Contributing_Source: CTRP
Contributing_Source: MedDRA
Contributing_Source: NICHD
ALT_DEFINITION: A malignant neoplasm originating in the nuclear layer of the retina.
ALT_DEFINITION: A malignant tumor that originates in the nuclear layer of the retina. As the most common primary tumor of the eye in children, retinoblastoma is still relatively uncommon, accounting for only 1% of all malignant tumors in pediatric patients. Approximately 95% of cases are diagnosed before age 5. These tumors may be multifocal, bilateral, congenital, inherited, or acquired. Seventy-five percent of retinoblastomas are unilateral; 60% occur sporadically. A predisposition to retinoblastoma has been associated with 13q14 cytogenetic abnormalities. Patients with the inherited form also appear to be at increased risk for secondary nonocular malignancies such as osteosarcoma, malignant fibrous histiocytoma, and fibrosarcoma.
ALT_DEFINITION: Cancer that forms in the tissues of the retina (the light-sensitive layers of nerve tissue at the back of the eye). Retinoblastoma usually occurs in children younger than 5 years. It may be hereditary or nonhereditary (sporadic).
ICD-O-3_Code: 9510/3
Neoplastic_Status: Malignant
Legacy_Concept_Name: Retinoblastoma
NICHD_Hierarchy_Term: Retinoblastoma
has exact synonym: RB
has exact synonym: RETINOBLASTOMA, MALIGNANT
has exact synonym: Retinoblastoma
has exact synonym: retinoblastoma
in subset: oncotree slim

Axiom
annotated source: Retinoblastoma
annotated property: definition
annotated target: A malignant tumor that originates in the nuclear layer of the retina. As the most common primary tumor of the eye in children, retinoblastoma is still relatively uncommon, accounting for only 1% of all malignant tumors in pediatric patients. Approximately 95% of cases are diagnosed before age 5. These tumors may be multifocal, bilateral, congenital, inherited, or acquired. Seventy-five percent of retinoblastomas are unilateral; 60% occur sporadically. A predisposition to retinoblastoma has been associated with 13q14 cytogenetic abnormalities. Patients with the inherited form also appear to be at increased risk for secondary nonocular malignancies such as osteosarcoma, malignant fibrous histiocytoma, and fibrosarcoma.
def-source: NCI

Axiom
annotated source: Retinoblastoma
annotated property: ALT_DEFINITION
annotated target: A malignant neoplasm originating in the nuclear layer of the retina.
def-source: CDISC

Axiom
annotated source: Retinoblastoma
annotated property: ALT_DEFINITION
annotated target: A malignant tumor that originates in the nuclear layer of the retina. As the most common primary tumor of the eye in children, retinoblastoma is still relatively uncommon, accounting for only 1% of all malignant tumors in pediatric patients. Approximately 95% of cases are diagnosed before age 5. These tumors may be multifocal, bilateral, congenital, inherited, or acquired. Seventy-five percent of retinoblastomas are unilateral; 60% occur sporadically. A predisposition to retinoblastoma has been associated with 13q14 cytogenetic abnormalities. Patients with the inherited form also appear to be at increased risk for secondary nonocular malignancies such as osteosarcoma, malignant fibrous histiocytoma, and fibrosarcoma.
def-source: NICHD

Axiom
annotated source: Retinoblastoma
annotated property: ALT_DEFINITION
annotated target: Cancer that forms in the tissues of the retina (the light-sensitive layers of nerve tissue at the back of the eye). Retinoblastoma usually occurs in children younger than 5 years. It may be hereditary or nonhereditary (sporadic).
def-source: NCI-GLOSS

Axiom
annotated source: Retinoblastoma
annotated property: has exact synonym
annotated target: RB
term-group: AB
term-source: NCI

Axiom
annotated source: Retinoblastoma
annotated property: has exact synonym
annotated target: RB
term-group: SY
term-source: CDISC

Axiom
annotated source: Retinoblastoma
annotated property: has exact synonym
annotated target: RETINOBLASTOMA, MALIGNANT
term-group: PT
term-source: CDISC

Axiom
annotated source: Retinoblastoma
annotated property: has exact synonym
annotated target: Retinoblastoma
term-group: PT
term-source: CTEP
source-code: 10038918
subsource-name: SDC

Axiom
annotated source: Retinoblastoma
annotated property: has exact synonym
annotated target: Retinoblastoma
term-group: PT
term-source: CTRP

Axiom
annotated source: Retinoblastoma
annotated property: has exact synonym
annotated target: Retinoblastoma
term-group: PT
term-source: NCI

Axiom
annotated source: Retinoblastoma
annotated property: has exact synonym
annotated target: Retinoblastoma
term-group: PT
term-source: NICHD

Axiom
annotated source: Retinoblastoma
annotated property: has exact synonym
annotated target: retinoblastoma
term-group: PT
term-source: NCI-GLOSS
source-code: CDR0000046774

Ovarian Serous Adenocarcinoma
type: Class
definition: An adenocarcinoma that arises from the ovary and is characterized by the presence of malignant epithelial cells that, in well differentiated tumors, resemble the epithelium of the fallopian tube or, in poorly differentiated tumors, show anaplastic features and marked nuclear atypia.
Concept_In_Subset: NCIT C126659
code: C7550
Semantic_Type: Neoplastic Process
Preferred_Name: Ovarian Serous Adenocarcinoma
UMLS_CUI: C1335177
Neoplastic_Status: Malignant
Legacy_Concept_Name: Ovarian_Serous_Adenocarcinoma
has exact synonym: Ovarian Serous Adenocarcinoma
has exact synonym: Ovarian Serous Carcinoma
has exact synonym: Serous Adenocarcinoma of Ovary
has exact synonym: Serous Adenocarcinoma of the Ovary
has exact synonym: Serous Carcinoma of Ovary
has exact synonym: Serous Carcinoma of the Ovary
in subset: oncotree slim

Axiom
annotated source: Ovarian Serous Adenocarcinoma
annotated property: definition
annotated target: An adenocarcinoma that arises from the ovary and is characterized by the presence of malignant epithelial cells that, in well differentiated tumors, resemble the epithelium of the fallopian tube or, in poorly differentiated tumors, show anaplastic features and marked nuclear atypia.
def-source: NCI

Axiom
annotated source: Ovarian Serous Adenocarcinoma
annotated property: has exact synonym
annotated target: Ovarian Serous Adenocarcinoma
term-group: PT
term-source: NCI

Axiom
annotated source: Ovarian Serous Adenocarcinoma
annotated property: has exact synonym
annotated target: Ovarian Serous Adenocarcinoma
term-group: SY
term-source: NCI
source-code: TCGA
subsource-name: caDSR

Axiom
annotated source: Ovarian Serous Adenocarcinoma
annotated property: has exact synonym
annotated target: Ovarian Serous Carcinoma
term-group: SY
term-source: NCI

Axiom
annotated source: Ovarian Serous Adenocarcinoma
annotated property: has exact synonym
annotated target: Serous Adenocarcinoma of Ovary
term-group: SY
term-source: NCI

Axiom
annotated source: Ovarian Serous Adenocarcinoma
annotated property: has exact synonym
annotated target: Serous Adenocarcinoma of the Ovary
term-group: SY
term-source: NCI

Axiom
annotated source: Ovarian Serous Adenocarcinoma
annotated property: has exact synonym
annotated target: Serous Carcinoma of Ovary
term-group: SY
term-source: NCI

Axiom
annotated source: Ovarian Serous Adenocarcinoma
annotated property: has exact synonym
annotated target: Serous Carcinoma of the Ovary
term-group: SY
term-source: NCI

Endometrial Carcinoma
type: Class
definition: A malignant tumor arising from the epithelium that lines the cavity of the uterine body. The vast majority of endometrial carcinomas are adenocarcinomas; squamous cell and adenosquamous carcinomas represent a minority of the cases. Endometrioid adenocarcinoma is the most frequently seen variant of endometrial adenocarcinoma. Uterine bleeding is an initial clinical sign. The prognosis depends on the stage of the tumor, the depth of myometrial wall invasion, and the degree of differentiation.
Concept_In_Subset: NCIT C116977
Concept_In_Subset: NCIT C126659
Concept_In_Subset: NCIT C61410
Concept_In_Subset: NCIT C77526
Concept_In_Subset: NCIT C88025
code: C7558
Semantic_Type: Neoplastic Process
Display_Name: Endometrial Cancer
Preferred_Name: Endometrial Carcinoma
UMLS_CUI: C0476089
Contributing_Source: CDISC
Contributing_Source: CTRP
ALT_DEFINITION: A malignant epithelial neoplasm arising from the lining of the uterine body cavity.
ALT_DEFINITION: Cancer that forms in the tissue lining the uterus (the small, hollow, pear-shaped organ in a woman's pelvis in which a fetus develops). Most endometrial cancers are adenocarcinomas (cancers that begin in cells that make and release mucus and other fluids).
Neoplastic_Status: Malignant
Legacy_Concept_Name: Endometrial_Carcinoma
has exact synonym: CARCINOMA, ENDOMETRIAL, MALIGNANT
has exact synonym: Carcinoma of Endometrium
has exact synonym: Carcinoma of the Endometrium
has exact synonym: Endometrial Cancer
has exact synonym: Endometrial Carcinoma
has exact synonym: endometrial cancer
in subset: oncotree slim

Axiom
annotated source: Endometrial Carcinoma
annotated property: definition
annotated target: A malignant tumor arising from the epithelium that lines the cavity of the uterine body. The vast majority of endometrial carcinomas are adenocarcinomas; squamous cell and adenosquamous carcinomas represent a minority of the cases. Endometrioid adenocarcinoma is the most frequently seen variant of endometrial adenocarcinoma. Uterine bleeding is an initial clinical sign. The prognosis depends on the stage of the tumor, the depth of myometrial wall invasion, and the degree of differentiation.
def-source: NCI

Axiom
annotated source: Endometrial Carcinoma
annotated property: ALT_DEFINITION
annotated target: A malignant epithelial neoplasm arising from the lining of the uterine body cavity.
def-source: CDISC

Axiom
annotated source: Endometrial Carcinoma
annotated property: ALT_DEFINITION
annotated target: Cancer that forms in the tissue lining the uterus (the small, hollow, pear-shaped organ in a woman's pelvis in which a fetus develops). Most endometrial cancers are adenocarcinomas (cancers that begin in cells that make and release mucus and other fluids).
def-source: NCI-GLOSS

Axiom
annotated source: Endometrial Carcinoma
annotated property: has exact synonym
annotated target: CARCINOMA, ENDOMETRIAL, MALIGNANT
term-group: PT
term-source: CDISC

Axiom
annotated source: Endometrial Carcinoma
annotated property: has exact synonym
annotated target: Carcinoma of Endometrium
term-group: SY
term-source: CDISC

Axiom
annotated source: Endometrial Carcinoma
annotated property: has exact synonym
annotated target: Carcinoma of Endometrium
term-group: SY
term-source: NCI

Axiom
annotated source: Endometrial Carcinoma
annotated property: has exact synonym
annotated target: Carcinoma of the Endometrium
term-group: SY
term-source: CDISC

Axiom
annotated source: Endometrial Carcinoma
annotated property: has exact synonym
annotated target: Carcinoma of the Endometrium
term-group: SY
term-source: NCI

Axiom
annotated source: Endometrial Carcinoma
annotated property: has exact synonym
annotated target: Endometrial Cancer
term-group: DN
term-source: CTRP

Axiom
annotated source: Endometrial Carcinoma
annotated property: has exact synonym
annotated target: Endometrial Cancer
term-group: PT
term-source: CTRP

Axiom
annotated source: Endometrial Carcinoma
annotated property: has exact synonym
annotated target: Endometrial Carcinoma
term-group: PT
term-source: NCI

Axiom
annotated source: Endometrial Carcinoma
annotated property: has exact synonym
annotated target: Endometrial Carcinoma
term-group: SY
term-source: CTRP

Axiom
annotated source: Endometrial Carcinoma
annotated property: has exact synonym
annotated target: Endometrial Carcinoma
term-group: SY
term-source: NCI
source-code: TCGA
subsource-name: caDSR

Axiom
annotated source: Endometrial Carcinoma
annotated property: has exact synonym
annotated target: endometrial cancer
term-group: PT
term-source: NCI-GLOSS
source-code: CDR0000444987

Thymic Carcinoma
type: Class
subclass of: Thymus Epithelial Neoplasm
definition: A diverse group of carcinomas of the thymus gland, previously known as thymoma type C (WHO-1999). It includes morphologic variants derived from purely epithelial cells, as well as from cells with neuroendocrine differentiation.
Concept_In_Subset: NCIT C116977
Concept_In_Subset: NCIT C126659
code: C7569
Semantic_Type: Neoplastic Process
Display_Name: Thymic Carcinoma
Preferred_Name: Thymic Carcinoma
UMLS_CUI: C0205969
Contributing_Source: CTRP
ALT_DEFINITION: A rare type of thymus gland cancer. It usually spreads, has a high risk of recurrence, and has a poor survival rate. Thymic carcinoma is divided into subtypes, depending on the types of cells in which the cancer began.
ICD-O-3_Code: 8586/3
Neoplastic_Status: Malignant
Legacy_Concept_Name: Thymoma_Type_C
has exact synonym: Thymic Carcinoma
has exact synonym: Thymic Carcinoma (Excluding Well Differentiated Thymic Carcinoma)
has exact synonym: Thymic Carcinoma Excluding Well Differentiated Thymic Carcinoma
has exact synonym: Thymoma Type C
has exact synonym: thymic carcinoma
has exact synonym: type C thymoma
in subset: oncotree slim

Axiom
annotated source: Thymic Carcinoma
annotated property: definition
annotated target: A diverse group of carcinomas of the thymus gland, previously known as thymoma type C (WHO-1999). It includes morphologic variants derived from purely epithelial cells, as well as from cells with neuroendocrine differentiation.
def-source: NCI

Axiom
annotated source: Thymic Carcinoma
annotated property: ALT_DEFINITION
annotated target: A rare type of thymus gland cancer. It usually spreads, has a high risk of recurrence, and has a poor survival rate. Thymic carcinoma is divided into subtypes, depending on the types of cells in which the cancer began.
def-source: NCI-GLOSS

Axiom
annotated source: Thymic Carcinoma
annotated property: has exact synonym
annotated target: Thymic Carcinoma
term-group: PT
term-source: CTRP

Axiom
annotated source: Thymic Carcinoma
annotated property: has exact synonym
annotated target: Thymic Carcinoma
term-group: PT
term-source: NCI

Axiom
annotated source: Thymic Carcinoma
annotated property: has exact synonym
annotated target: Thymic Carcinoma (Excluding Well Differentiated Thymic Carcinoma)
term-group: SY
term-source: NCI

Axiom
annotated source: Thymic Carcinoma
annotated property: has exact synonym
annotated target: Thymic Carcinoma Excluding Well Differentiated Thymic Carcinoma
term-group: SY
term-source: NCI

Axiom
annotated source: Thymic Carcinoma
annotated property: has exact synonym
annotated target: Thymoma Type C
term-group: AQS
term-source: NCI

Axiom
annotated source: Thymic Carcinoma
annotated property: has exact synonym
annotated target: thymic carcinoma
term-group: PT
term-source: NCI-GLOSS
source-code: CDR0000455462

Axiom
annotated source: Thymic Carcinoma
annotated property: has exact synonym
annotated target: type C thymoma
term-group: PT
term-source: NCI-GLOSS
source-code: CDR0000467224

Kidney Medullary Carcinoma
type: Class
definition: A type of renal carcinoma affecting mostly young African-Americans. It is located in the medulla of the kidney, and follows an aggressive clinical course. Most reported cases have shown metastatic disease at the time of diagnosis.
Concept_In_Subset: NCIT C126659
code: C7572
Semantic_Type: Neoplastic Process
Preferred_Name: Kidney Medullary Carcinoma
UMLS_CUI: C4049328
Neoplastic_Status: Malignant
Legacy_Concept_Name: Renal_Medullary_Carcinoma
has exact synonym: Kidney Medullary Carcinoma
has exact synonym: Renal Medullary Carcinoma
in subset: oncotree slim

Axiom
annotated source: Kidney Medullary Carcinoma
annotated property: definition
annotated target: A type of renal carcinoma affecting mostly young African-Americans. It is located in the medulla of the kidney, and follows an aggressive clinical course. Most reported cases have shown metastatic disease at the time of diagnosis.
def-source: NCI

Axiom
annotated source: Kidney Medullary Carcinoma
annotated property: has exact synonym
annotated target: Kidney Medullary Carcinoma
term-group: PT
term-source: NCI

Axiom
annotated source: Kidney Medullary Carcinoma
annotated property: has exact synonym
annotated target: Renal Medullary Carcinoma
term-group: SY
term-source: NCI

Breast Phyllodes Tumor
type: Class
definition: A benign, malignant, or borderline circumscribed biphasic neoplasm that arises from the breast. It usually affects middle-aged women. It is characterized by the presence of a double layer of epithelial cells that are arranged in clefts, surrounded by a spindle cell mesenchymal (stromal) component.
Concept_In_Subset: NCIT C102905
Concept_In_Subset: NCIT C103041
Concept_In_Subset: NCIT C126659
code: C7575
Semantic_Type: Neoplastic Process
Preferred_Name: Breast Phyllodes Tumor
UMLS_CUI: C0238031
Contributing_Source: CTEP
Neoplastic_Status: Undetermined
Legacy_Concept_Name: Phyllodes_Tumor_of_the_Breast
has exact synonym: Breast Cystosarcoma Phyllodes
has exact synonym: Breast Phyllodes Neoplasm
has exact synonym: Breast Phyllodes Tumor
has exact synonym: Cystosarcoma Phyllodes of Breast
has exact synonym: Cystosarcoma Phyllodes of the Breast
has exact synonym: Cystosarcoma phylloides - breast
has exact synonym: Cystosarcoma phylloides of the breast
has exact synonym: Phyllodes Breast Neoplasm
has exact synonym: Phyllodes Breast Tumor
has exact synonym: Phyllodes Neoplasm of Breast
has exact synonym: Phyllodes Neoplasm of the Breast
has exact synonym: Phyllodes Tumor of Breast
has exact synonym: Phyllodes Tumor of the Breast
in subset: oncotree slim

Axiom
annotated source: Breast Phyllodes Tumor
annotated property: definition
annotated target: A benign, malignant, or borderline circumscribed biphasic neoplasm that arises from the breast. It usually affects middle-aged women. It is characterized by the presence of a double layer of epithelial cells that are arranged in clefts, surrounded by a spindle cell mesenchymal (stromal) component.
def-source: NCI

Axiom
annotated source: Breast Phyllodes Tumor
annotated property: has exact synonym
annotated target: Breast Cystosarcoma Phyllodes
term-group: SY
term-source: NCI

Axiom
annotated source: Breast Phyllodes Tumor
annotated property: has exact synonym
annotated target: Breast Phyllodes Neoplasm
term-group: SY
term-source: NCI

Axiom
annotated source: Breast Phyllodes Tumor
annotated property: has exact synonym
annotated target: Breast Phyllodes Tumor
term-group: PT
term-source: NCI

Axiom
annotated source: Breast Phyllodes Tumor
annotated property: has exact synonym
annotated target: Cystosarcoma Phyllodes of Breast
term-group: SY
term-source: NCI

Axiom
annotated source: Breast Phyllodes Tumor
annotated property: has exact synonym
annotated target: Cystosarcoma Phyllodes of the Breast
term-group: SY
term-source: NCI

Axiom
annotated source: Breast Phyllodes Tumor
annotated property: has exact synonym
annotated target: Cystosarcoma phylloides - breast
term-group: SY
term-source: CTEP
source-code: 10053130
subsource-name: SDC

Axiom
annotated source: Breast Phyllodes Tumor
annotated property: has exact synonym
annotated target: Cystosarcoma phylloides of the breast
term-group: PT
term-source: CTEP
source-code: 10053130
subsource-name: SDC

Axiom
annotated source: Breast Phyllodes Tumor
annotated property: has exact synonym
annotated target: Phyllodes Breast Neoplasm
term-group: SY
term-source: NCI

Axiom
annotated source: Breast Phyllodes Tumor
annotated property: has exact synonym
annotated target: Phyllodes Breast Tumor
term-group: SY
term-source: NCI

Axiom
annotated source: Breast Phyllodes Tumor
annotated property: has exact synonym
annotated target: Phyllodes Neoplasm of Breast
term-group: SY
term-source: NCI

Axiom
annotated source: Breast Phyllodes Tumor
annotated property: has exact synonym
annotated target: Phyllodes Neoplasm of the Breast
term-group: SY
term-source: NCI

Axiom
annotated source: Breast Phyllodes Tumor
annotated property: has exact synonym
annotated target: Phyllodes Tumor of Breast
term-group: SY
term-source: NCI

Axiom
annotated source: Breast Phyllodes Tumor
annotated property: has exact synonym
annotated target: Phyllodes Tumor of the Breast
term-group: SY
term-source: NCI

Microcystic Adnexal Carcinoma
type: Class
subclass of: Sweat Gland Carcinoma
definition: A low grade adenocarcinoma with ductal differentiation, arising from the sweat glands. It presents as a scar usually in the face. It is characterized by the formation of small ducts and it frequently involves nerves and perineural spaces.
code: C7581
Semantic_Type: Neoplastic Process
Preferred_Name: Microcystic Adnexal Carcinoma
UMLS_CUI: C0346027
ICD-O-3_Code: 8407/3
Neoplastic_Status: Malignant
Legacy_Concept_Name: Microcystic_Adnexal_Carcinoma
has exact synonym: Eccrine Epithelioma
has exact synonym: Microcystic Adnexal Carcinoma
has exact synonym: Syringomatous Carcinoma
in subset: oncotree slim

Axiom
annotated source: Microcystic Adnexal Carcinoma
annotated property: definition
annotated target: A low grade adenocarcinoma with ductal differentiation, arising from the sweat glands. It presents as a scar usually in the face. It is characterized by the formation of small ducts and it frequently involves nerves and perineural spaces.
def-source: NCI

Axiom
annotated source: Microcystic Adnexal Carcinoma
annotated property: has exact synonym
annotated target: Eccrine Epithelioma
term-group: SY
term-source: NCI

Axiom
annotated source: Microcystic Adnexal Carcinoma
annotated property: has exact synonym
annotated target: Microcystic Adnexal Carcinoma
term-group: PT
term-source: NCI

Axiom
annotated source: Microcystic Adnexal Carcinoma
annotated property: has exact synonym
annotated target: Syringomatous Carcinoma
term-group: SY
term-source: NCI

Malignant Myoepithelioma
type: Class
definition: An infiltrating malignant tumor characterized by the presence of atypical cells with myoepithelial differentiation. Representative examples include malignant breast myoepithelioma and salivary gland myoepithelial carcinoma.
Concept_In_Subset: NCIT C61410
Concept_In_Subset: NCIT C77526
Concept_In_Subset: NCIT C88025
code: C7596
Semantic_Type: Neoplastic Process
Preferred_Name: Malignant Myoepithelioma
UMLS_CUI: C0334699
Contributing_Source: CDISC
ALT_DEFINITION: A malignant neoplasm composed of myoepithelial cells.
ICD-O-3_Code: 8982/3
Neoplastic_Status: Malignant
Legacy_Concept_Name: Myoepithelial_Carcinoma
has exact synonym: MYOEPITHELIOMA, MALIGNANT
has exact synonym: Malignant Myoepithelioma
has exact synonym: Myoepithelial Carcinoma
in subset: oncotree slim

Axiom
annotated source: Malignant Myoepithelioma
annotated property: definition
annotated target: An infiltrating malignant tumor characterized by the presence of atypical cells with myoepithelial differentiation. Representative examples include malignant breast myoepithelioma and salivary gland myoepithelial carcinoma.
def-source: NCI

Axiom
annotated source: Malignant Myoepithelioma
annotated property: ALT_DEFINITION
annotated target: A malignant neoplasm composed of myoepithelial cells.
def-source: CDISC

Axiom
annotated source: Malignant Myoepithelioma
annotated property: has exact synonym
annotated target: MYOEPITHELIOMA, MALIGNANT
term-group: PT
term-source: CDISC

Axiom
annotated source: Malignant Myoepithelioma
annotated property: has exact synonym
annotated target: Malignant Myoepithelioma
term-group: PT
term-source: NCI

Axiom
annotated source: Malignant Myoepithelioma
annotated property: has exact synonym
annotated target: Malignant Myoepithelioma
term-group: SY
term-source: CDISC

Axiom
annotated source: Malignant Myoepithelioma
annotated property: has exact synonym
annotated target: Myoepithelial Carcinoma
term-group: SY
term-source: CDISC

Axiom
annotated source: Malignant Myoepithelioma
annotated property: has exact synonym
annotated target: Myoepithelial Carcinoma
term-group: SY
term-source: NCI

Peritoneal Mesothelioma
type: Class
definition: A benign or malignant mesothelial neoplasm that arises from the peritoneum.
code: C7633
Semantic_Type: Neoplastic Process
Preferred_Name: Peritoneal Mesothelioma
UMLS_CUI: C1377610
Neoplastic_Status: Undetermined
Legacy_Concept_Name: Peritoneal_Mesothelioma
has exact synonym: Mesothelioma of Peritoneum
has exact synonym: Mesothelioma of the Peritoneum
has exact synonym: Peritoneal Mesothelioma
in subset: oncotree slim

Axiom
annotated source: Peritoneal Mesothelioma
annotated property: definition
annotated target: A benign or malignant mesothelial neoplasm that arises from the peritoneum.
def-source: NCI

Axiom
annotated source: Peritoneal Mesothelioma
annotated property: has exact synonym
annotated target: Mesothelioma of Peritoneum
term-group: SY
term-source: NCI

Axiom
annotated source: Peritoneal Mesothelioma
annotated property: has exact synonym
annotated target: Mesothelioma of the Peritoneum
term-group: SY
term-source: NCI

Axiom
annotated source: Peritoneal Mesothelioma
annotated property: has exact synonym
annotated target: Peritoneal Mesothelioma
term-group: PT
term-source: NCI

Solitary Fibrous Tumor
type: Class
definition: A localized neoplasm of probable fibroblastic derivation. It is characterized by the presence of round to spindle-shaped cells, hylanized stroma formation, thin-walled branching blood vessels, and thin bands of collagen.
Concept_In_Subset: NCIT C126659
code: C7634
Semantic_Type: Neoplastic Process
Preferred_Name: Solitary Fibrous Tumor
UMLS_CUI: C1266119
ICD-O-3_Code: 8815/0
ICD-O-3_Code: 8815/1
ICD-O-3_Code: 9051/0
Neoplastic_Status: Undetermined
Legacy_Concept_Name: Solitary_Fibrous_Tumor
has exact synonym: Hemangiopericytoma
has exact synonym: Localized Fibrous Mesothelioma
has exact synonym: Localized Fibrous Tumor
has exact synonym: SFT
has exact synonym: Solitary Fibrous Tumor
has exact synonym: Submesothelial Fibroma
in subset: oncotree slim

Axiom
annotated source: Solitary Fibrous Tumor
annotated property: definition
annotated target: A localized neoplasm of probable fibroblastic derivation. It is characterized by the presence of round to spindle-shaped cells, hylanized stroma formation, thin-walled branching blood vessels, and thin bands of collagen.
def-source: NCI

Axiom
annotated source: Solitary Fibrous Tumor
annotated property: has exact synonym
annotated target: Hemangiopericytoma
term-group: AQS
term-source: NCI

Axiom
annotated source: Solitary Fibrous Tumor
annotated property: has exact synonym
annotated target: Localized Fibrous Mesothelioma
term-group: AQS
term-source: NCI

Axiom
annotated source: Solitary Fibrous Tumor
annotated property: has exact synonym
annotated target: Localized Fibrous Tumor
term-group: SY
term-source: NCI

Axiom
annotated source: Solitary Fibrous Tumor
annotated property: has exact synonym
annotated target: SFT
term-group: AB
term-source: NCI

Axiom
annotated source: Solitary Fibrous Tumor
annotated property: has exact synonym
annotated target: Solitary Fibrous Tumor
term-group: PT
term-source: NCI

Axiom
annotated source: Solitary Fibrous Tumor
annotated property: has exact synonym
annotated target: Submesothelial Fibroma
term-group: AQS
term-source: NCI

Uveal Melanoma
type: Class
subclass of: NCIT C8562
definition: A melanoma derived from melanocytes of the uveal tract. It is the most common primary intraocular tumor in the United States and Western Europe. Similar to melanoma of the skin, it is rare in Africa and Asia. Diagnostic procedures include ophthalmoscopic exam, fluorescein angiography and ultrasound. Treatment includes: surgical excision of the eye, iridocyclectomy and tumor resection. Recent treatments also include radiotherapy or photo coagulation. Classification of uveal melanomas recognizes four cell types within these tumors: epithelioid, intermediate, mixed cell, and spindle cell types. The spindle cell type uveal melanomas are further sub-classified as spindle cell type A and spindle cell type B.
Concept_In_Subset: NCIT C118168
Concept_In_Subset: NCIT C61410
Concept_In_Subset: NCIT C77526
Concept_In_Subset: NCIT C88025
code: C7712
Semantic_Type: Neoplastic Process
Display_Name: Intraocular Melanoma
Preferred_Name: Uveal Melanoma
UMLS_CUI: C0220633
Contributing_Source: CDISC
Contributing_Source: CTRP
ALT_DEFINITION: A malignant neoplasm of the uvea composed of melanocytes.
ALT_DEFINITION: A rare cancer of melanocytes (cells that produce the pigment melanin) found in the eye.
Neoplastic_Status: Malignant
Legacy_Concept_Name: Uveal_Melanoma
has exact synonym: Intraocular Melanoma
has exact synonym: MELANOMA, UVEAL, MALIGNANT
has exact synonym: Melanoma of Uvea
has exact synonym: Melanoma of the Uvea
has exact synonym: Uveal Melanoma
has exact synonym: intraocular melanoma
in subset: oncotree slim

Axiom
annotated source: Uveal Melanoma
annotated property: definition
annotated target: A melanoma derived from melanocytes of the uveal tract. It is the most common primary intraocular tumor in the United States and Western Europe. Similar to melanoma of the skin, it is rare in Africa and Asia. Diagnostic procedures include ophthalmoscopic exam, fluorescein angiography and ultrasound. Treatment includes: surgical excision of the eye, iridocyclectomy and tumor resection. Recent treatments also include radiotherapy or photo coagulation. Classification of uveal melanomas recognizes four cell types within these tumors: epithelioid, intermediate, mixed cell, and spindle cell types. The spindle cell type uveal melanomas are further sub-classified as spindle cell type A and spindle cell type B.
def-source: NCI

Axiom
annotated source: Uveal Melanoma
annotated property: ALT_DEFINITION
annotated target: A malignant neoplasm of the uvea composed of melanocytes.
def-source: CDISC

Axiom
annotated source: Uveal Melanoma
annotated property: ALT_DEFINITION
annotated target: A rare cancer of melanocytes (cells that produce the pigment melanin) found in the eye.
def-source: NCI-GLOSS

Axiom
annotated source: Uveal Melanoma
annotated property: has exact synonym
annotated target: Intraocular Melanoma
term-group: SY
term-source: CDISC

Axiom
annotated source: Uveal Melanoma
annotated property: has exact synonym
annotated target: Intraocular Melanoma
term-group: SY
term-source: NCI

Axiom
annotated source: Uveal Melanoma
annotated property: has exact synonym
annotated target: MELANOMA, UVEAL, MALIGNANT
term-group: PT
term-source: CDISC

Axiom
annotated source: Uveal Melanoma
annotated property: has exact synonym
annotated target: Melanoma of Uvea
term-group: SY
term-source: CDISC

Axiom
annotated source: Uveal Melanoma
annotated property: has exact synonym
annotated target: Melanoma of Uvea
term-group: SY
term-source: NCI

Axiom
annotated source: Uveal Melanoma
annotated property: has exact synonym
annotated target: Melanoma of the Uvea
term-group: SY
term-source: CDISC

Axiom
annotated source: Uveal Melanoma
annotated property: has exact synonym
annotated target: Melanoma of the Uvea
term-group: SY
term-source: NCI

Axiom
annotated source: Uveal Melanoma
annotated property: has exact synonym
annotated target: Uveal Melanoma
term-group: PT
term-source: NCI

Axiom
annotated source: Uveal Melanoma
annotated property: has exact synonym
annotated target: intraocular melanoma
term-group: PT
term-source: NCI-GLOSS
source-code: CDR0000269460

Appendix Adenocarcinoma
type: Class
definition: A malignant neoplasm arising from the glandular epithelium of the appendix with invasion of the appendiceal wall beyond the muscularis mucosa. The majority of cases are well differentiated adenocarcinomas with mucinous stroma formation. Clinically, it may present as an abdominal mass or with symptoms of acute appendicitis. Patients with chronic ulcerative colitis are at a higher risk in developing appendiceal adenocarcinomas compared to the general population.
Concept_In_Subset: NCIT C126659
code: C7718
Semantic_Type: Neoplastic Process
Preferred_Name: Appendix Adenocarcinoma
UMLS_CUI: C0238003
Neoplastic_Status: Malignant
Legacy_Concept_Name: Appendix_Adenocarcinoma
has exact synonym: Adenocarcinoma of Appendix
has exact synonym: Adenocarcinoma of the Appendix
has exact synonym: Appendiceal Adenocarcinoma
has exact synonym: Appendix Adenocarcinoma
in subset: oncotree slim

Axiom
annotated source: Appendix Adenocarcinoma
annotated property: definition
annotated target: A malignant neoplasm arising from the glandular epithelium of the appendix with invasion of the appendiceal wall beyond the muscularis mucosa. The majority of cases are well differentiated adenocarcinomas with mucinous stroma formation. Clinically, it may present as an abdominal mass or with symptoms of acute appendicitis. Patients with chronic ulcerative colitis are at a higher risk in developing appendiceal adenocarcinomas compared to the general population.
def-source: NCI

Axiom
annotated source: Appendix Adenocarcinoma
annotated property: has exact synonym
annotated target: Adenocarcinoma of Appendix
term-group: SY
term-source: NCI

Axiom
annotated source: Appendix Adenocarcinoma
annotated property: has exact synonym
annotated target: Adenocarcinoma of the Appendix
term-group: SY
term-source: NCI

Axiom
annotated source: Appendix Adenocarcinoma
annotated property: has exact synonym
annotated target: Appendiceal Adenocarcinoma
term-group: SY
term-source: NCI

Axiom
annotated source: Appendix Adenocarcinoma
annotated property: has exact synonym
annotated target: Appendix Adenocarcinoma
term-group: PT
term-source: NCI

Small Intestinal Carcinoma
type: Class
definition: A carcinoma arising from the small intestine. The vast majority are adenocarcinomas. The remaining cases are adenosquamous, squamous, or undifferentiated carcinomas.
Concept_In_Subset: NCIT C102905
Concept_In_Subset: NCIT C103068
Concept_In_Subset: NCIT C116977
Concept_In_Subset: NCIT C126659
code: C7724
Semantic_Type: Neoplastic Process
Display_Name: Small Intestinal Cancer
Preferred_Name: Small Intestinal Carcinoma
UMLS_CUI: C0238196
Contributing_Source: CTEP
Contributing_Source: CTRP
ALT_DEFINITION: A rare cancer that forms in tissues of the small intestine (the part of the digestive tract between the stomach and the large intestine). The most common type is adenocarcinoma (cancer that begins in cells that make and release mucus and other fluids). Other types of small intestine cancer include sarcoma (cancer that begins in connective or supportive tissue), carcinoid tumor (a slow-growing type of cancer), gastrointestinal stromal tumor (a type of soft tissue sarcoma), and lymphoma (cancer that begins in immune system cells).
Neoplastic_Status: Malignant
Legacy_Concept_Name: Small_Intestinal_Carcinoma
has exact synonym: Cancer of Small Bowel
has exact synonym: Cancer of the Small Bowel
has exact synonym: Carcinoma of Small Bowel
has exact synonym: Carcinoma of Small Intestine
has exact synonym: Carcinoma of the Small Bowel
has exact synonym: Carcinoma of the Small Intestine
has exact synonym: Small Bowel Cancer
has exact synonym: Small Bowel Carcinoma
has exact synonym: Small Intestinal Cancer
has exact synonym: Small Intestinal Carcinoma
has exact synonym: Small Intestine Cancer
has exact synonym: Small intestine cancer, NOS
has exact synonym: small intestine cancer
in subset: oncotree slim

Axiom
annotated source: Small Intestinal Carcinoma
annotated property: definition
annotated target: A carcinoma arising from the small intestine. The vast majority are adenocarcinomas. The remaining cases are adenosquamous, squamous, or undifferentiated carcinomas.
def-source: NCI

first: Mammal
rest:
  first: Manufactured Object
  rest:
    first: Medical Device
    rest:
      first: Mental Process
      rest:
        first: Mental or Behavioral Dysfunction

first: Molecular Biology Research Technique
rest:
  first: Molecular Function
  rest:
    first: Molecular Sequence
    rest:
      first: Natural Phenomenon or Process
      rest:
        first: Neoplastic Process

first: Nucleic Acid, Nucleoside, or Nucleotide
rest:
  first: Nucleotide Sequence
  rest:
    first: Occupation or Discipline
    rest:
      first: Occupational Activity
      rest:
        first: Organ or Tissue Function

first: Organic Chemical
rest:
  first: Organism
  rest:
    first: Organism Attribute
    rest:
      first: Organism Function
      rest:
        first: Organization

first: Pathologic Function
rest:
  first: Patient or Disabled Group
  rest:
    first: Pharmacologic Substance
    rest:
      first: Phenomenon or Process
      rest:
        first: Physical Object

first: Physiologic Function
rest:
  first: Plant
  rest:
    first: Population Group
    rest:
      first: Professional Society
      rest:
        first: Professional or Occupational Group

first: Qualitative Concept
rest:
  first: Quantitative Concept
  rest:
    first: Receptor
    rest:
      first: Regulation or Law
      rest:
        first: Reptile

first: Research Activity
rest:
  first: Research Device
  rest:
    first: Self-help or Relief Organization
    rest:
      first: Sign or Symptom
      rest:
        first: Social Behavior

first: Spatial Concept
rest:
  first: Substance
  rest:
    first: Temporal Concept
    rest:
      first: Therapeutic or Preventive Procedure
      rest:
        first: Tissue

first: Vertebrate
rest:
  first: Virus
  rest:
    first: Vitamin
    rest: nil