NCIt Neoplasm Core Module
type: Ontology
version IRI: neoplasm-core.owl
comment: Module extract from NCIt OBO Edition (Plus) based on the NCIt Neoplasm Core. This module is based on the SLME BOT algorithm, starting with the list of Neoplasm Core terms.

is a defining property chain axiom
type: AnnotationProperty
IAO_0000115: If R <- P o Q is a defining property chain axiom, then it also holds that R -> P o Q. Note that this cannot be expressed directly in OWL

is a defining property chain axiom where second argument is reflexive
type: AnnotationProperty
IAO_0000115: If R <- P o Q is a defining property chain axiom, then (1) R -> P o Q holds and (2) Q is either reflexive or locally reflexive. A corollary of this is that P SubPropertyOf R.

database_cross_reference
type: AnnotationProperty

comment
type: AnnotationProperty

label
type: AnnotationProperty

part_of
type: ObjectProperty
inverse of: has_part
type: TransitiveProperty
IAO_0000115: a core relation that holds between a part and its whole
database_cross_reference: BFO:0000050
has OBO namespace: uberon
id: part_of
shorthand: part_of
label: part of

has_part
type: ObjectProperty
type: TransitiveProperty
IAO_0000115: a core relation that holds between a whole and its part
database_cross_reference: BFO:0000051
has OBO namespace: uberon
id: has_part
shorthand: has_part
label: has part

participates in
type: ObjectProperty
database_cross_reference: BFO:0000056
has OBO namespace: uberon
id: participates_in
shorthand: participates_in

preceded_by
type: ObjectProperty
sub property of: ends after
inverse of: precedes
type: TransitiveProperty
domain: BFO_0000003
range: BFO_0000003
property chain axiom: part_of
IAO_0000115: X preceded_by Y iff: end(Y) before_or_simultaneous_with start(X)
IAO_0000115: x is preceded by y if and only if the time point at which y ends is before or equivalent to the time point at which x starts. Formally: x preceded by y iff ω(y) <= α(x), where α is a function that maps a process to a start point, and ω is a function that maps a process to an end point.
database_cross_reference: BFO:0000062
has exact synonym: is preceded by
has exact synonym: takes place after
has OBO namespace: uberon
id: preceded_by
shorthand: preceded_by
label: preceded by

Axiom
annotated source: preceded_by
annotated property: hasExactSynonym
annotated target: is preceded by
database_cross_reference: SIO:000249

Axiom
annotated source: preceded_by
annotated property: hasExactSynonym
annotated target: takes place after
database_cross_reference: Allen:precedes

precedes
type: ObjectProperty
sub property of: temporally related to
type: TransitiveProperty
domain: BFO_0000003
range: BFO_0000003
property chain axiom: part_of
IAO_0000115: x precedes y if and only if the time point at which x ends is before or equivalent to the time point at which y starts. Formally: x precedes y iff ω(x) <= α(y), where α is a function that maps a process to a start point, and ω is a function that maps a process to an end point.
database_cross_reference: BFO:0000063
has OBO namespace: uberon
id: precedes
shorthand: precedes

occurs in
type: ObjectProperty
inverse of: contains process
domain: BFO_0000003
range: BFO_0000004
property chain axiom: part_of
IAO_0000115: b occurs_in c =def b is a process and c is a material entity or immaterial entity& there exists a spatiotemporal region r and b occupies_spatiotemporal_region r.& forall(t) if b exists_at t then c exists_at t & there exist spatial regions s and s’ where & b spatially_projects_onto s at t& c is occupies_spatial_region s’ at t& s is a proper_continuant_part_of s’ at t

contains process
type: ObjectProperty
IAO_0000115: [copied from inverse property 'occurs in'] b occurs_in c =def b is a process and c is a material entity or immaterial entity& there exists a spatiotemporal region r and b occupies_spatiotemporal_region r.& forall(t) if b exists_at t then c exists_at t & there exist spatial regions s and s’ where & b spatially_projects_onto s at t& c is occupies_spatial_region s’ at t& s is a proper_continuant_part_of s’ at t
database_cross_reference: BFO:0000067
has OBO namespace: uberon
id: contains_process
shorthand: contains_process

anterior_to
type: ObjectProperty
inverse of: posterior_to
type: TransitiveProperty
IAO_0000115: x anterior_to y iff x is further along the antero-posterior axis than y, towards the head. An antero-posterior axis is an axis that bisects an organism from head end to opposite end of body or tail: bearer
IAO_0000115: x anterior_to y iff x is further along the antero-posterior axis than y, towards the head. An antero-posterior axis is an axis that extends through an organism from head end to opposite end of body or tail.
created by: cjm
creation date: 2009-07-31T02:15:46Z
database_cross_reference: BSPO:0000096
has OBO namespace: uberon
id: anterior_to
shorthand: anterior_to

Axiom
annotated source: anterior_to
annotated property: IAO_0000115
annotated target: x anterior_to y iff x is further along the antero-posterior axis than y, towards the head. An antero-posterior axis is an axis that bisects an organism from head end to opposite end of body or tail: bearer
database_cross_reference: http://orcid.org/0000-0002-6601-2165

Axiom
annotated source: anterior_to
annotated property: IAO_0000115
annotated target: x anterior_to y iff x is further along the antero-posterior axis than y, towards the head. An antero-posterior axis is an axis that extends through an organism from head end to opposite end of body or tail.
database_cross_reference: BSPO:cjm

distal_to
type: ObjectProperty
inverse of: proximal_to
type: TransitiveProperty
IAO_0000115: x distal_to y iff x is further along the proximo-distal axis than y, towards the appendage tip. A proximo-distal axis extends from tip of an appendage (distal) to where it joins the body (proximal).
database_cross_reference: BSPO:0000097
has OBO namespace: uberon
id: distal_to
shorthand: distal_to

Axiom
annotated source: distal_to
annotated property: IAO_0000115
annotated target: x distal_to y iff x is further along the proximo-distal axis than y, towards the appendage tip. A proximo-distal axis extends from tip of an appendage (distal) to where it joins the body (proximal).
database_cross_reference: http://orcid.org/0000-0002-6601-2165

Axiom
annotated source: distal_to
annotated property: IAO_0000115
annotated target: x distal_to y iff x is further along the proximo-distal axis than y, towards the appendage tip. A proximo-distal axis extends from tip of an appendage (distal) to where it joins the body (proximal).
database_cross_reference: BSPO:cjm

dorsal_to
type: ObjectProperty
inverse of: ventral_to
type: TransitiveProperty
IAO_0000115: x dorsal_to y iff x is further along the dorso-ventral axis than y, towards the back. A dorso-ventral axis is an axis that bisects an organism from back (e.g. spinal column) to front (e.g. belly).
IAO_0000115: x dorsal_to y iff x is further along the dorso-ventral axis than y, towards the back. A dorso-ventral axis is an axis that extends through an organism from back (e.g. spinal column) to front (e.g. belly).
database_cross_reference: BSPO:0000098
has OBO namespace: uberon
id: dorsal_to
shorthand: dorsal_to

Axiom
annotated source: dorsal_to
annotated property: IAO_0000115
annotated target: x dorsal_to y iff x is further along the dorso-ventral axis than y, towards the back. A dorso-ventral axis is an axis that bisects an organism from back (e.g. spinal column) to front (e.g. belly).
database_cross_reference: http://orcid.org/0000-0002-6601-2165

Axiom
annotated source: dorsal_to
annotated property: IAO_0000115
annotated target: x dorsal_to y iff x is further along the dorso-ventral axis than y, towards the back. A dorso-ventral axis is an axis that extends through an organism from back (e.g. spinal column) to front (e.g. belly).
database_cross_reference: BSPO:cjm

posterior_to
type: ObjectProperty
type: TransitiveProperty
IAO_0000115: x posterior_to y iff x is further along the antero-posterior axis than y, towards the body/tail. An antero-posterior axis is an axis that bisects an organism from head end to opposite end of body or tail.
IAO_0000115: x posterior_to y iff x is further along the antero-posterior axis than y, towards the body/tail. An antero-posterior axis is an axis that extends through an organism from head end to opposite end of body or tail.
database_cross_reference: BSPO:0000099
has narrow synonym: caudal_to
has OBO namespace: uberon
id: posterior_to
shorthand: posterior_to

Axiom
annotated source: posterior_to
annotated property: IAO_0000115
annotated target: x posterior_to y iff x is further along the antero-posterior axis than y, towards the body/tail. An antero-posterior axis is an axis that bisects an organism from head end to opposite end of body or tail.
database_cross_reference: http://orcid.org/0000-0002-6601-2165

Axiom
annotated source: posterior_to
annotated property: IAO_0000115
annotated target: x posterior_to y iff x is further along the antero-posterior axis than y, towards the body/tail. An antero-posterior axis is an axis that extends through an organism from head end to opposite end of body or tail.
database_cross_reference: BSPO:cjm

proximal_to
type: ObjectProperty
type: TransitiveProperty
IAO_0000115: x proximal_to y iff x is closer to the point of attachment with the body than y.
database_cross_reference: BSPO:0000100
has OBO namespace: uberon
id: proximal_to
shorthand: proximal_to

Axiom
annotated source: proximal_to
annotated property: IAO_0000115
annotated target: x proximal_to y iff x is closer to the point of attachment with the body than y.
database_cross_reference: http://orcid.org/0000-0002-6601-2165

Axiom
annotated source: proximal_to
annotated property: IAO_0000115
annotated target: x proximal_to y iff x is closer to the point of attachment with the body than y.
database_cross_reference: BSPO:cjm

ventral_to
type: ObjectProperty
type: TransitiveProperty
IAO_0000115: x ventral_to y iff x is further along the dorso-ventral axis than y, towards the front. A dorso-ventral axis is an axis that bisects an organism from back (e.g. spinal column) to front (e.g. belly).
IAO_0000115: x ventral_to y iff x is further along the dorso-ventral axis than y, towards the front. A dorso-ventral axis is an axis that extends through an organism from back (e.g. spinal column) to front (e.g. belly).
database_cross_reference: BSPO:0000102
has OBO namespace: uberon
id: ventral_to
shorthand: ventral_to

Axiom
annotated source: ventral_to
annotated property: IAO_0000115
annotated target: x ventral_to y iff x is further along the dorso-ventral axis than y, towards the front. A dorso-ventral axis is an axis that bisects an organism from back (e.g. spinal column) to front (e.g. belly).
database_cross_reference: http://orcid.org/0000-0002-6601-2165

Axiom
annotated source: ventral_to
annotated property: IAO_0000115
annotated target: x ventral_to y iff x is further along the dorso-ventral axis than y, towards the front. A dorso-ventral axis is an axis that extends through an organism from back (e.g. spinal column) to front (e.g. belly).
database_cross_reference: BSPO:cjm

deep_to
type: ObjectProperty
inverse of: superficial_to
type: TransitiveProperty
IAO_0000115: Further away from the surface of the organism. Thus, the muscular layer is deep to the skin, but superficial to the intestines.
database_cross_reference: BSPO:0000107
has OBO namespace: uberon
id: deep_to
shorthand: deep_to

Axiom
annotated source: deep_to
annotated property: IAO_0000115
annotated target: Further away from the surface of the organism. Thus, the muscular layer is deep to the skin, but superficial to the intestines.
database_cross_reference: http://orcid.org/0000-0002-6601-2165

Axiom
annotated source: deep_to
annotated property: IAO_0000115
annotated target: Further away from the surface of the organism. Thus, the muscular layer is deep to the skin, but superficial to the intestines.
database_cross_reference: BSPO:cjm

superficial_to
type: ObjectProperty
type: TransitiveProperty
IAO_0000115: Near the outer surface of the organism. Thus, skin is superficial to the muscle layer.
database_cross_reference: BSPO:0000108
has OBO namespace: uberon
id: superficial_to
shorthand: superficial_to

Axiom
annotated source: superficial_to
annotated property: IAO_0000115
annotated target: Near the outer surface of the organism. Thus, skin is superficial to the muscle layer.
database_cross_reference: http://orcid.org/0000-0002-6601-2165

Axiom
annotated source: superficial_to
annotated property: IAO_0000115
annotated target: Near the outer surface of the organism. Thus, skin is superficial to the muscle layer.
database_cross_reference: BSPO:cjm

in_left_side_of
type: ObjectProperty
sub property of: in_lateral_side_of
inverse of: in_right_side_of
IAO_0000115: X in_left_side_of Y <=> if Y is subdivided into left and right portions, X is part_of the left portion.
IAO_0000115: X in_left_side_of Y <=> if Y is subdivided into two left and right portions, X is part_of the left portion.
database_cross_reference: BSPO:0000120
has OBO namespace: uberon
id: in_left_side_of
shorthand: in_left_side_of

Axiom
annotated source: in_left_side_of
annotated property: IAO_0000115
annotated target: X in_left_side_of Y <=> if Y is subdivided into left and right portions, X is part_of the left portion.
database_cross_reference: BSPO:PATO_mtg_2009

Axiom
annotated source: in_left_side_of
annotated property: IAO_0000115
annotated target: X in_left_side_of Y <=> if Y is subdivided into two left and right portions, X is part_of the left portion.
database_cross_reference: BSPO:PATO_mtg_2009

in_right_side_of
type: ObjectProperty
sub property of: in_lateral_side_of
IAO_0000115: X in_right_side_of Y <=> if Y is subdivided into left and right portions, X is part_of the right portion.
IAO_0000115: X in_right_side_of Y <=> if Y is subdivided into two left and right portions, X is part_of the right portion.
database_cross_reference: BSPO:0000121
has OBO namespace: uberon
id: in_right_side_of
shorthand: in_right_side_of

Axiom
annotated source: in_right_side_of
annotated property: IAO_0000115
annotated target: X in_right_side_of Y <=> if Y is subdivided into left and right portions, X is part_of the right portion.
database_cross_reference: BSPO:PATO_mtg_2009

Axiom
annotated source: in_right_side_of
annotated property: IAO_0000115
annotated target: X in_right_side_of Y <=> if Y is subdivided into two left and right portions, X is part_of the right portion.
database_cross_reference: BSPO:PATO_mtg_2009

in_posterior_side_of
type: ObjectProperty
sub property of: part_of
IAO_0000115: X posterior_side_of Y <=> if Y is subdivided into two anterior and posterior portions, X is part_of the posterior portion.
database_cross_reference: BSPO:0000122
has OBO namespace: uberon
id: in_posterior_side_of
shorthand: in_posterior_side_of

Axiom
annotated source: in_posterior_side_of
annotated property: IAO_0000115
annotated target: X posterior_side_of Y <=> if Y is subdivided into two anterior and posterior portions, X is part_of the posterior portion.
database_cross_reference: BSPO:PATO_mtg_2009

in_anterior_side_of
type: ObjectProperty
sub property of: part_of
IAO_0000115: X anterior_side_of Y <=> if Y is subdivided into two anterior and posterior portions, X is part_of the anterior portion.
database_cross_reference: BSPO:0000123
has OBO namespace: uberon
id: in_anterior_side_of
shorthand: in_anterior_side_of

Axiom
annotated source: in_anterior_side_of
annotated property: IAO_0000115
annotated target: X anterior_side_of Y <=> if Y is subdivided into two anterior and posterior portions, X is part_of the anterior portion.
database_cross_reference: BSPO:PATO_mtg_2009

in_proximal_side_of
type: ObjectProperty
sub property of: part_of
inverse of: in_distal_side_of
IAO_0000115: X proximal_side_of Y <=> if Y is subdivided into distal and proximal portions, X is part_of the proximal portion.
IAO_0000115: x in_proximal_side_of y <=> if y is subdivided into two proximal and distal portions, y is part_of the proximal portion.
database_cross_reference: BSPO:0000124
has OBO namespace: uberon
id: in_proximal_side_of
shorthand: in_proximal_side_of

Axiom
annotated source: in_proximal_side_of
annotated property: IAO_0000115
annotated target: X proximal_side_of Y <=> if Y is subdivided into distal and proximal portions, X is part_of the proximal portion.
database_cross_reference: BSPO:PATO_mtg_2009

Axiom
annotated source: in_proximal_side_of
annotated property: IAO_0000115
annotated target: x in_proximal_side_of y <=> if y is subdivided into two proximal and distal portions, y is part_of the proximal portion.
database_cross_reference: BSPO:PATO_mtg_2009

in_distal_side_of
type: ObjectProperty
sub property of: part_of
IAO_0000115: X distal_side_of Y <=> if Y is subdivided into distal and proximal portions, X is part_of the distal portion.
IAO_0000115: x in_distal_side_of y <=> if y is subdivided into two proximal and distal portions, y is part_of the distal portion.
database_cross_reference: BSPO:0000125
has OBO namespace: uberon
id: in_distal_side_of
shorthand: in_distal_side_of

Axiom
annotated source: in_distal_side_of
annotated property: IAO_0000115
annotated target: X distal_side_of Y <=> if Y is subdivided into distal and proximal portions, X is part_of the distal portion.
database_cross_reference: BSPO:PATO_mtg_2009

Axiom
annotated source: in_distal_side_of
annotated property: IAO_0000115
annotated target: x in_distal_side_of y <=> if y is subdivided into two proximal and distal portions, y is part_of the distal portion.
database_cross_reference: BSPO:PATO_mtg_2009

in_lateral_side_of
type: ObjectProperty
sub property of: part_of
IAO_0000115: X in_lateral_side_of Y <=> if X is in_left_side_of Y or X is in_right_side_of Y. X is often, but not always a paired structure
database_cross_reference: BSPO:0000126
has OBO namespace: uberon
id: in_lateral_side_of
shorthand: in_lateral_side_of

Axiom
annotated source: in_lateral_side_of
annotated property: IAO_0000115
annotated target: X in_lateral_side_of Y <=> if X is in_left_side_of Y or X is in_right_side_of Y. X is often, but not always a paired structure
database_cross_reference: https://orcid.org/0000-0002-6601-2165

Axiom
annotated source: in_lateral_side_of
annotated property: IAO_0000115
annotated target: X in_lateral_side_of Y <=> if X is in_left_side_of Y or X is in_right_side_of Y. X is often, but not always a paired structure
database_cross_reference: UBERON:cjm

in_deep_part_of
type: ObjectProperty
sub property of: part_of
IAO_0000115: X superficial_part_of Y <=> if Y is subdivided into two superficial and deep portions, X is part_of the deep portion.
database_cross_reference: BSPO:0001101
has OBO namespace: uberon
id: in_deep_part_of
shorthand: in_deep_part_of

Axiom
annotated source: in_deep_part_of
annotated property: IAO_0000115
annotated target: X superficial_part_of Y <=> if Y is subdivided into two superficial and deep portions, X is part_of the deep portion.
database_cross_reference: http://orcid.org/0000-0002-6601-2165

Axiom
annotated source: in_deep_part_of
annotated property: IAO_0000115
annotated target: X superficial_part_of Y <=> if Y is subdivided into two superficial and deep portions, X is part_of the deep portion.
database_cross_reference: BSPO:cjm

proximalmost_part_of
type: ObjectProperty
sub property of: in_proximal_side_of
IAO_0000115: X proximalmost_part_of Y <=> X is in_proximal_side_of Y and X is adjacent_to the proximal boundary of Y
IAO_0000115: X proximalmost_part_of Y <=> X is part_of Y and X is adjacent_to the proximal boundary of Y
database_cross_reference: BSPO:0001106
has OBO namespace: uberon
id: proximalmost_part_of
shorthand: proximalmost_part_of

Axiom
annotated source: proximalmost_part_of
annotated property: IAO_0000115
annotated target: X proximalmost_part_of Y <=> X is in_proximal_side_of Y and X is adjacent_to the proximal boundary of Y
database_cross_reference: https://orcid.org/0000-0002-6601-2165

Axiom
annotated source: proximalmost_part_of
annotated property: IAO_0000115
annotated target: X proximalmost_part_of Y <=> X is part_of Y and X is adjacent_to the proximal boundary of Y
database_cross_reference: https://orcid.org/0000-0002-6601-2165

immediately_deep_to
type: ObjectProperty
sub property of: deep_to
sub property of: adjacent_to
inverse of: immediately_superficial_to
IAO_0000115: This relation holds when both the deep_to and ajdacent_to relationship similarly hold.
IAO_0000115: x immediately_deep_to y iff x deep_to y and x is contiguous with y.
database_cross_reference: BSPO:0001107
has OBO namespace: uberon
id: immediately_deep_to
shorthand: immediately_deep_to

Axiom
annotated source: immediately_deep_to
annotated property: IAO_0000115
annotated target: This relation holds when both the deep_to and ajdacent_to relationship similarly hold.
database_cross_reference: http://orcid.org/0000-0002-6601-2165

Axiom
annotated source: immediately_deep_to
annotated property: IAO_0000115
annotated target: x immediately_deep_to y iff x deep_to y and x is contiguous with y.
database_cross_reference: BSPO:curators

distalmost_part_of
type: ObjectProperty
sub property of: in_distal_side_of
IAO_0000115: X distalmost_part_of Y <=> X is in_distal_side_of Y and X is adjacent_to the distal boundary of Y
IAO_0000115: X distalmost_part_of Y <=> X is part_of Y and X is adjacent_to the distal boundary of Y
database_cross_reference: BSPO:0001108
has OBO namespace: uberon
id: distalmost_part_of
shorthand: distalmost_part_of

Axiom
annotated source: distalmost_part_of
annotated property: IAO_0000115
annotated target: X distalmost_part_of Y <=> X is in_distal_side_of Y and X is adjacent_to the distal boundary of Y
database_cross_reference: https://orcid.org/0000-0002-6601-2165

Axiom
annotated source: distalmost_part_of
annotated property: IAO_0000115
annotated target: X distalmost_part_of Y <=> X is part_of Y and X is adjacent_to the distal boundary of Y
database_cross_reference: https://orcid.org/0000-0002-6601-2165

preaxialmost_part_of
type: ObjectProperty
sub property of: part_of
database_cross_reference: BSPO:0001113
has OBO namespace: uberon
id: preaxialmost_part_of
shorthand: preaxialmost_part_of

intersects_midsagittal_plane_of
type: ObjectProperty
sub property of: part_of
IAO_0000115: X intersects_median_plane of iff X crosses the midine plane of Y.
database_cross_reference: BSPO:0005001
has OBO namespace: uberon
id: intersects_midsagittal_plane_of
shorthand: intersects_midsagittal_plane_of

immediately_superficial_to
type: ObjectProperty
sub property of: superficial_to
sub property of: adjacent_to
IAO_0000115: x immediately_superficial_to y iff x superficial_to y and x is contiguous with y.
database_cross_reference: BSPO:0015014
has OBO namespace: uberon
id: immediately_superficial_to
shorthand: immediately_superficial_to

Axiom
annotated source: immediately_superficial_to
annotated property: IAO_0000115
annotated target: x immediately_superficial_to y iff x superficial_to y and x is contiguous with y.
database_cross_reference: BSPO:curators

in_dorsal_side_of
type: ObjectProperty
sub property of: part_of
database_cross_reference: BSPO:0015101
has OBO namespace: uberon
id: in_dorsal_side_of
shorthand: in_dorsal_side_of

Disease_Has_Associated_Anatomic_Site
type: ObjectProperty
domain: NCIT C7057
range: NCIT C12219
IAO_0000115: A role used to relate a disease to the general site, structure or system where the specific pathological process is located. The domain and the range for this role are 'Disease, Disorder or Finding' and 'Anatomic Structure, System, or Substance', respectively.
NCIT NHC0: R100
NCIT P106: Conceptual Entity
NCIT P107: Has Associated Anatomic Site
NCIT P108: Disease_Has_Associated_Anatomic_Site
NCIT P98: The role, Disease_Has_Associated_Anatomic_Site, is more general than the role, Disease_Has_Primary_Anatomic_Site. Furthermore, when viewed with the role, Disease_Has_Metastatic_Anatomic_Site, there emerges a role hierarchy, where one role specializes the meaning of another, more general role. Roles relating disease to anatomy start with a general assertion of association, often at very high level (e.g. Skin Disorder and Skin), and then add more specific primary/metastatic associations where appropriate for more specific concepts.
has exact synonym: Disease_Has_Associated_Anatomic_Site

Axiom
annotated source: Disease_Has_Associated_Anatomic_Site
annotated property: IAO_0000115
annotated target: A role used to relate a disease to the general site, structure or system where the specific pathological process is located. The domain and the range for this role are 'Disease, Disorder or Finding' and 'Anatomic Structure, System, or Substance', respectively.
NCIT P378: NCI

Axiom
annotated source: Disease_Has_Associated_Anatomic_Site
annotated property: hasExactSynonym
annotated target: Disease_Has_Associated_Anatomic_Site
NCIT P383: PT
NCIT P384: NCI

Disease_Has_Primary_Anatomic_Site
type: ObjectProperty
domain: NCIT C7057
range: NCIT C12219
IAO_0000115: A role used to relate a disease to the anatomical site where the originating pathological process is located. The domain and the range for this role are 'Disease, Disorder or Finding' and 'Anatomic Structure, System, or Substance', respectively.
NCIT NHC0: R101
NCIT P106: Conceptual Entity
NCIT P107: Has Primary Anatomic Site
NCIT P108: Disease_Has_Primary_Anatomic_Site
NCIT P98: This role can be viewed as a specialization of Disease_Has_Associated_Anatomic_Site.
has exact synonym: Disease_Has_Primary_Anatomic_Site

Axiom
annotated source: Disease_Has_Primary_Anatomic_Site
annotated property: IAO_0000115
annotated target: A role used to relate a disease to the anatomical site where the originating pathological process is located. The domain and the range for this role are 'Disease, Disorder or Finding' and 'Anatomic Structure, System, or Substance', respectively.
NCIT P378: NCI

Axiom
annotated source: Disease_Has_Primary_Anatomic_Site
annotated property: hasExactSynonym
annotated target: Disease_Has_Primary_Anatomic_Site
NCIT P383: PT
NCIT P384: NCI

Disease_Has_Metastatic_Anatomic_Site
type: ObjectProperty
domain: NCIT C7057
range: NCIT C12219
IAO_0000115: A role used to relate a disease to the site of a metastatic lesion associated with the disease. The domain and the range for this role are 'Disease, Disorder or Finding' and 'Anatomic Structure, System, or Substance', respectively.
NCIT NHC0: R102
NCIT P106: Conceptual Entity
NCIT P107: Has Metastatic Anatomic Site
NCIT P108: Disease_Has_Metastatic_Anatomic_Site
NCIT P98: The role can be viewed as a specialization of Disease_Has_Associated_Anatomic_Site.
has exact synonym: Disease_Has_Metastatic_Anatomic_Site

Axiom
annotated source: Disease_Has_Metastatic_Anatomic_Site
annotated property: IAO_0000115
annotated target: A role used to relate a disease to the site of a metastatic lesion associated with the disease. The domain and the range for this role are 'Disease, Disorder or Finding' and 'Anatomic Structure, System, or Substance', respectively.
NCIT P378: NCI

Axiom
annotated source: Disease_Has_Metastatic_Anatomic_Site
annotated property: hasExactSynonym
annotated target: Disease_Has_Metastatic_Anatomic_Site
NCIT P383: PT
NCIT P384: NCI

Disease_Has_Normal_Tissue_Origin
type: ObjectProperty
domain: NCIT C7057
range: NCIT C12219
IAO_0000115: A role used to relate a disease to the type of normal tissue in which the disease process began. The domain and the range for this role are 'Disease, Disorder or Finding' and 'Anatomic Structure, System, or Substance', respectively.
NCIT NHC0: R103
NCIT P106: Conceptual Entity
NCIT P107: Has Normal Tissue Origin
NCIT P108: Disease_Has_Normal_Tissue_Origin
NCIT P98: This non-defining role represents non-essential characteristics which are true in some, but not all, cases, yet have an association frequent enough to be of interest.
has exact synonym: Disease_Has_Normal_Tissue_Origin

Axiom
annotated source: Disease_Has_Normal_Tissue_Origin
annotated property: IAO_0000115
annotated target: A role used to relate a disease to the type of normal tissue in which the disease process began. The domain and the range for this role are 'Disease, Disorder or Finding' and 'Anatomic Structure, System, or Substance', respectively.
NCIT P378: NCI

Axiom
annotated source: Disease_Has_Normal_Tissue_Origin
annotated property: hasExactSynonym
annotated target: Disease_Has_Normal_Tissue_Origin
NCIT P383: PT
NCIT P384: NCI

Disease_Has_Normal_Cell_Origin
type: ObjectProperty
domain: NCIT C7057
range: NCIT C12219
IAO_0000115: A role used to relate a disease to the type of normal cell in which the disease process begins. The domain and the range for this role are 'Disease, Disorder or Finding' and 'Anatomic Structure, System, or Substance', respectively.
NCIT NHC0: R104
NCIT P106: Conceptual Entity
NCIT P107: Has Normal Cell Origin
NCIT P108: Disease_Has_Normal_Cell_Origin
has exact synonym: Disease_Has_Normal_Cell_Origin

Axiom
annotated source: Disease_Has_Normal_Cell_Origin
annotated property: IAO_0000115
annotated target: A role used to relate a disease to the type of normal cell in which the disease process begins. The domain and the range for this role are 'Disease, Disorder or Finding' and 'Anatomic Structure, System, or Substance', respectively.
NCIT P378: NCI

Axiom
annotated source: Disease_Has_Normal_Cell_Origin
annotated property: hasExactSynonym
annotated target: Disease_Has_Normal_Cell_Origin
NCIT P383: PT
NCIT P384: NCI

Disease_Has_Abnormal_Cell
type: ObjectProperty
domain: NCIT C7057
range: NCIT C12913
IAO_0000115: A role used to relate a disease to the type of neoplastic cell present in and characteristic of the disease. The domain and the range for this role are 'Disease, Disorder or Finding' and 'Abnormal Cell', respectively.
NCIT NHC0: R105
NCIT P106: Conceptual Entity
NCIT P107: Has Abnormal Cell
NCIT P108: Disease_Has_Abnormal_Cell
has exact synonym: Disease_Has_Abnormal_Cell

Axiom
annotated source: Disease_Has_Abnormal_Cell
annotated property: IAO_0000115
annotated target: A role used to relate a disease to the type of neoplastic cell present in and characteristic of the disease. The domain and the range for this role are 'Disease, Disorder or Finding' and 'Abnormal Cell', respectively.
NCIT P378: NCI

Axiom
annotated source: Disease_Has_Abnormal_Cell
annotated property: hasExactSynonym
annotated target: Disease_Has_Abnormal_Cell
NCIT P383: PT
NCIT P384: NCI

Disease_Has_Molecular_Abnormality
type: ObjectProperty
domain: NCIT C7057
range: NCIT C3910
IAO_0000115: A role used to relate a disease to a molecular abnormality that is present in the specified disease state. The domain and the range for this role are 'Disease, Disorder or Finding' and 'Molecular Abnormality', respectively.
NCIT NHC0: R106
NCIT P106: Conceptual Entity
NCIT P107: Has Molecular Abnormality
NCIT P108: Disease_Has_Molecular_Abnormality
has exact synonym: Disease_Has_Molecular_Abnormality

Axiom
annotated source: Disease_Has_Molecular_Abnormality
annotated property: IAO_0000115
annotated target: A role used to relate a disease to a molecular abnormality that is present in the specified disease state. The domain and the range for this role are 'Disease, Disorder or Finding' and 'Molecular Abnormality', respectively.
NCIT P378: NCI

Axiom
annotated source: Disease_Has_Molecular_Abnormality
annotated property: hasExactSynonym
annotated target: Disease_Has_Molecular_Abnormality
NCIT P383: PT
NCIT P384: NCI

Disease_Has_Cytogenetic_Abnormality
type: ObjectProperty
domain: NCIT C7057
range: NCIT C3910
IAO_0000115: A role used to relate a disease to the type of chromosomal abnormality present in the specified disease state. The domain and the range for this role are 'Disease, Disorder or Finding' and 'Molecular Abnormality', respectively.
NCIT NHC0: R107
NCIT P106: Conceptual Entity
NCIT P107: Has Cytogenetic Abnormality
NCIT P108: Disease_Has_Cytogenetic_Abnormality
has exact synonym: Disease_Has_Cytogenetic_Abnormality

Axiom
annotated source: Disease_Has_Cytogenetic_Abnormality
annotated property: IAO_0000115
annotated target: A role used to relate a disease to the type of chromosomal abnormality present in the specified disease state. The domain and the range for this role are 'Disease, Disorder or Finding' and 'Molecular Abnormality', respectively.
NCIT P378: NCI

Axiom
annotated source: Disease_Has_Cytogenetic_Abnormality
annotated property: hasExactSynonym
annotated target: Disease_Has_Cytogenetic_Abnormality
NCIT P383: PT
NCIT P384: NCI

Disease_Has_Finding
type: ObjectProperty
domain: NCIT C7057
range: NCIT C7057
IAO_0000115: A role used to relate a disease to a clinical observation, sign or symptom present in and characteristic of the disease. Both the domain and range for this role are 'Disease, Disorder or Finding'.
NCIT NHC0: R108
NCIT P106: Conceptual Entity
NCIT P107: Has Finding
NCIT P108: Disease_Has_Finding
has exact synonym: Disease_Has_Finding

Axiom
annotated source: Disease_Has_Finding
annotated property: IAO_0000115
annotated target: A role used to relate a disease to a clinical observation, sign or symptom present in and characteristic of the disease. Both the domain and range for this role are 'Disease, Disorder or Finding'.
NCIT P378: NCI

Axiom
annotated source: Disease_Has_Finding
annotated property: hasExactSynonym
annotated target: Disease_Has_Finding
NCIT P383: PT
NCIT P384: NCI

Disease_Is_Grade
type: ObjectProperty
domain: NCIT C7057
range: NCIT C20189
IAO_0000115: A role used to relate a disease to a grading system which classifies the cancer cells in terms of how abnormal they appear when examined under a microscope. The domain and the range for this role are 'Disease, Disorder or Finding' and 'Property or_Attribute', respectively.
NCIT NHC0: R110
NCIT P106: Conceptual Entity
NCIT P107: Is Grade
NCIT P108: Disease_Is_Grade
has exact synonym: Disease_Is_Grade

Axiom
annotated source: Disease_Is_Grade
annotated property: IAO_0000115
annotated target: A role used to relate a disease to a grading system which classifies the cancer cells in terms of how abnormal they appear when examined under a microscope. The domain and the range for this role are 'Disease, Disorder or Finding' and 'Property or_Attribute', respectively.
NCIT P378: NCI

Axiom
annotated source: Disease_Is_Grade
annotated property: hasExactSynonym
annotated target: Disease_Is_Grade
NCIT P383: PT
NCIT P384: NCI

Disease_May_Have_Normal_Cell_Origin
type: ObjectProperty
domain: NCIT C7057
range: NCIT C12219
IAO_0000115: A role used to represent that a normal cell type will only be the type of origin in some cases of the disease. The domain and the range for this role are 'Disease, Disorder or Finding' and 'Anatomic Structure, System, or Substance', respectively.
NCIT NHC0: R112
NCIT P106: Conceptual Entity
NCIT P107: May Have Normal Cell Origin
NCIT P108: Disease_May_Have_Normal_Cell_Origin
has exact synonym: Disease_May_Have_Normal_Cell_Origin

Axiom
annotated source: Disease_May_Have_Normal_Cell_Origin
annotated property: IAO_0000115
annotated target: A role used to represent that a normal cell type will only be the type of origin in some cases of the disease. The domain and the range for this role are 'Disease, Disorder or Finding' and 'Anatomic Structure, System, or Substance', respectively.
NCIT P378: NCI

Axiom
annotated source: Disease_May_Have_Normal_Cell_Origin
annotated property: hasExactSynonym
annotated target: Disease_May_Have_Normal_Cell_Origin
NCIT P383: PT
NCIT P384: NCI

Disease_May_Have_Abnormal_Cell
type: ObjectProperty
domain: NCIT C7057
range: NCIT C12913
IAO_0000115: A role used to represent that particular neoplastic cell types will only be present in some cases of the disease. The domain and the range for this role are 'Disease, Disorder or Finding' and 'Abnormal Cell', respectively.
NCIT NHC0: R113
NCIT P106: Conceptual Entity
NCIT P107: May Have Abnormal Cell
NCIT P108: Disease_May_Have_Abnormal_Cell
has exact synonym: Disease_May_Have_Abnormal_Cell

Axiom
annotated source: Disease_May_Have_Abnormal_Cell
annotated property: IAO_0000115
annotated target: A role used to represent that particular neoplastic cell types will only be present in some cases of the disease. The domain and the range for this role are 'Disease, Disorder or Finding' and 'Abnormal Cell', respectively.
NCIT P378: NCI

Axiom
annotated source: Disease_May_Have_Abnormal_Cell
annotated property: hasExactSynonym
annotated target: Disease_May_Have_Abnormal_Cell
NCIT P383: PT
NCIT P384: NCI

Disease_May_Have_Cytogenetic_Abnormality
type: ObjectProperty
domain: NCIT C7057
range: NCIT C3910
IAO_0000115: A role used to represent that a particular cytogenetic abnormality will only be present in some cases of the disease. The domain and the range for this role are 'Disease, Disorder or Finding' and 'Molecular Abnormality', respectively.
NCIT NHC0: R114
NCIT P106: Conceptual Entity
NCIT P107: May Have Cytogenetic Abnormality
NCIT P108: Disease_May_Have_Cytogenetic_Abnormality
has exact synonym: Disease_May_Have_Cytogenetic_Abnormality

Axiom
annotated source: Disease_May_Have_Cytogenetic_Abnormality
annotated property: IAO_0000115
annotated target: A role used to represent that a particular cytogenetic abnormality will only be present in some cases of the disease. The domain and the range for this role are 'Disease, Disorder or Finding' and 'Molecular Abnormality', respectively.
NCIT P378: NCI

Axiom
annotated source: Disease_May_Have_Cytogenetic_Abnormality
annotated property: hasExactSynonym
annotated target: Disease_May_Have_Cytogenetic_Abnormality
NCIT P383: PT
NCIT P384: NCI

Disease_May_Have_Finding
type: ObjectProperty
domain: NCIT C7057
range: NCIT C7057
IAO_0000115: A role used to represent that a clinical observation, sign or symptom will only be observed in some cases of the disease. Both the domain and range for this role are 'Disease, Disorder or Finding'.
NCIT NHC0: R115
NCIT P106: Conceptual Entity
NCIT P107: May Have Finding
NCIT P108: Disease_May_Have_Finding
has exact synonym: Disease_May_Have_Finding

Axiom
annotated source: Disease_May_Have_Finding
annotated property: IAO_0000115
annotated target: A role used to represent that a clinical observation, sign or symptom will only be observed in some cases of the disease. Both the domain and range for this role are 'Disease, Disorder or Finding'.
NCIT P378: NCI

Axiom
annotated source: Disease_May_Have_Finding
annotated property: hasExactSynonym
annotated target: Disease_May_Have_Finding
NCIT P383: PT
NCIT P384: NCI

Disease_May_Have_Associated_Disease
type: ObjectProperty
domain: NCIT C7057
range: NCIT C7057
IAO_0000115: A role used to represent that another disease or disorder will only be observed in some cases of the specified disease. Both the domain and the range for this role are 'Disease, Disorder or Finding'.
NCIT NHC0: R116
NCIT P106: Conceptual Entity
NCIT P107: May Have Associated Disease
NCIT P108: Disease_May_Have_Associated_Disease
has exact synonym: Disease_May_Have_Associated_Disease

Axiom
annotated source: Disease_May_Have_Associated_Disease
annotated property: IAO_0000115
annotated target: A role used to represent that another disease or disorder will only be observed in some cases of the specified disease. Both the domain and the range for this role are 'Disease, Disorder or Finding'.
NCIT P378: NCI

Axiom
annotated source: Disease_May_Have_Associated_Disease
annotated property: hasExactSynonym
annotated target: Disease_May_Have_Associated_Disease
NCIT P383: PT
NCIT P384: NCI

Disease_Has_Associated_Disease
type: ObjectProperty
domain: NCIT C7057
range: NCIT C7057
IAO_0000115: A role used to relate a disease to another disease or disorder, but without specification or limitation of the relationship (causality or timing for example). Both the domain and the range for this role are 'Disease, Disorder or Finding'.
NCIT NHC0: R126
NCIT P106: Conceptual Entity
NCIT P107: Has Associated Disease
NCIT P108: Disease_Has_Associated_Disease
has exact synonym: Disease_Has_Associated_Disease

Axiom
annotated source: Disease_Has_Associated_Disease
annotated property: IAO_0000115
annotated target: A role used to relate a disease to another disease or disorder, but without specification or limitation of the relationship (causality or timing for example). Both the domain and the range for this role are 'Disease, Disorder or Finding'.
NCIT P378: NCI

Axiom
annotated source: Disease_Has_Associated_Disease
annotated property: hasExactSynonym
annotated target: Disease_Has_Associated_Disease
NCIT P383: PT
NCIT P384: NCI

Gene_Product_Is_Element_In_Pathway
type: ObjectProperty
domain: NCIT C26548
range: NCIT C20633
IAO_0000115: A role used to assert a relationship between a gene product and a biochemical pathway in which it participates. This relationship is used only when a gene product has been implicated in a pathway by the curated source (Biocarta, KEGG or PID). The domain and range for this role are 'Gene Product' and 'Biochemical Pathway', respectively.
NCIT NHC0: R131
NCIT P106: Conceptual Entity
NCIT P107: Is Element In Pathway
NCIT P108: Gene_Product_Is_Element_In_Pathway
NCIT P98: In NCI Thesaurus, pathways are derived from BioCarta and KEGG and are associated with genes and proteins that comprise these pathways.
has exact synonym: Gene_Product_Is_Element_In_Pathway

Axiom
annotated source: Gene_Product_Is_Element_In_Pathway
annotated property: IAO_0000115
annotated target: A role used to assert a relationship between a gene product and a biochemical pathway in which it participates. This relationship is used only when a gene product has been implicated in a pathway by the curated source (Biocarta, KEGG or PID). The domain and range for this role are 'Gene Product' and 'Biochemical Pathway', respectively.
NCIT P378: NCI

Axiom
annotated source: Gene_Product_Is_Element_In_Pathway
annotated property: hasExactSynonym
annotated target: Gene_Product_Is_Element_In_Pathway
NCIT P383: PT
NCIT P384: NCI

Gene_Has_Abnormality
type: ObjectProperty
domain: NCIT C16612
range: NCIT C3910
IAO_0000115: A role used to establish a link between a gene and the genetic or molecular abnormalities that have been observed in human cells and tissues associated with cancers (e.g., over- or under-expressed, amplified, translocated). The domain and range for this role are 'Gene' and 'Molecular Abnormality', respectively.
NCIT NHC0: R132
NCIT P106: Conceptual Entity
NCIT P107: Has Abnormality
NCIT P108: Gene_Has_Abnormality
has exact synonym: Gene_Has_Abnormality

Axiom
annotated source: Gene_Has_Abnormality
annotated property: IAO_0000115
annotated target: A role used to establish a link between a gene and the genetic or molecular abnormalities that have been observed in human cells and tissues associated with cancers (e.g., over- or under-expressed, amplified, translocated). The domain and range for this role are 'Gene' and 'Molecular Abnormality', respectively.
NCIT P378: NCI

Axiom
annotated source: Gene_Has_Abnormality
annotated property: hasExactSynonym
annotated target: Gene_Has_Abnormality
NCIT P383: PT
NCIT P384: NCI

Gene_Product_Has_Abnormality
type: ObjectProperty
domain: NCIT C26548
range: NCIT C3910
IAO_0000115: A role used to establish a link between a gene product and the molecular abnormalities that are observed in human cells and tissues in association with diseases such as cancers (e.g., over or under-expression of gene product). The domain and range for this role are 'Gene Product' and 'Molecular Abnormality', respectively.
NCIT NHC0: R133
NCIT P106: Conceptual Entity
NCIT P107: Has Abnormality
NCIT P108: Gene_Product_Has_Abnormality
has exact synonym: Gene_Product_Has_Abnormality

Axiom
annotated source: Gene_Product_Has_Abnormality
annotated property: IAO_0000115
annotated target: A role used to establish a link between a gene product and the molecular abnormalities that are observed in human cells and tissues in association with diseases such as cancers (e.g., over or under-expression of gene product). The domain and range for this role are 'Gene Product' and 'Molecular Abnormality', respectively.
NCIT P378: NCI

Axiom
annotated source: Gene_Product_Has_Abnormality
annotated property: hasExactSynonym
annotated target: Gene_Product_Has_Abnormality
NCIT P383: PT
NCIT P384: NCI

Disease_Excludes_Primary_Anatomic_Site
type: ObjectProperty
domain: NCIT C7057
range: NCIT C12219
IAO_0000115: A specializing role which may be used to override Disease_Has_Associated_Anatomic_Site. The domain and the range for this role are 'Disease, Disorder or Finding' and 'Anatomic Structure, System, or Substance', respectively.
NCIT NHC0: R135
NCIT P106: Conceptual Entity
NCIT P107: Excludes Primary Anatomic Site
NCIT P108: Disease_Excludes_Primary_Anatomic_Site
has exact synonym: Disease_Excludes_Primary_Anatomic_Site

Axiom
annotated source: Disease_Excludes_Primary_Anatomic_Site
annotated property: IAO_0000115
annotated target: A specializing role which may be used to override Disease_Has_Associated_Anatomic_Site. The domain and the range for this role are 'Disease, Disorder or Finding' and 'Anatomic Structure, System, or Substance', respectively.
NCIT P378: NCI

Axiom
annotated source: Disease_Excludes_Primary_Anatomic_Site
annotated property: hasExactSynonym
annotated target: Disease_Excludes_Primary_Anatomic_Site
NCIT P383: PT
NCIT P384: NCI

Disease_Excludes_Normal_Tissue_Origin
type: ObjectProperty
domain: NCIT C7057
range: NCIT C12219
IAO_0000115: A specializing role which may be used to override Disease_Has_Normal_Tissue_Origin. The domain and the range for this role are 'Disease, Disorder or Finding' and 'Anatomic Structure, System, or Substance', respectively.
NCIT NHC0: R137
NCIT P106: Conceptual Entity
NCIT P107: Excludes Normal Tissue Origin
NCIT P108: Disease_Excludes_Normal_Tissue_Origin
has exact synonym: Disease_Excludes_Normal_Tissue_Origin

Axiom
annotated source: Disease_Excludes_Normal_Tissue_Origin
annotated property: IAO_0000115
annotated target: A specializing role which may be used to override Disease_Has_Normal_Tissue_Origin. The domain and the range for this role are 'Disease, Disorder or Finding' and 'Anatomic Structure, System, or Substance', respectively.
NCIT P378: NCI

Axiom
annotated source: Disease_Excludes_Normal_Tissue_Origin
annotated property: hasExactSynonym
annotated target: Disease_Excludes_Normal_Tissue_Origin
NCIT P383: PT
NCIT P384: NCI

Disease_Excludes_Normal_Cell_Origin
type: ObjectProperty
domain: NCIT C7057
range: NCIT C12219
IAO_0000115: A specializing role which may be used to override Disease_Has_Normal_Cell_Origin. The domain and the range for this role are 'Disease, Disorder or Finding' and 'Anatomic Structure, System, or Substance', respectively.
NCIT NHC0: R138
NCIT P106: Conceptual Entity
NCIT P107: Excludes Normal Cell Origin
NCIT P108: Disease_Excludes_Normal_Cell_Origin
has exact synonym: Disease_Excludes_Normal_Cell_Origin

Axiom
annotated source: Disease_Excludes_Normal_Cell_Origin
annotated property: IAO_0000115
annotated target: A specializing role which may be used to override Disease_Has_Normal_Cell_Origin. The domain and the range for this role are 'Disease, Disorder or Finding' and 'Anatomic Structure, System, or Substance', respectively.
NCIT P378: NCI

Axiom
annotated source: Disease_Excludes_Normal_Cell_Origin
annotated property: hasExactSynonym
annotated target: Disease_Excludes_Normal_Cell_Origin
NCIT P383: PT
NCIT P384: NCI

Disease_Excludes_Abnormal_Cell
type: ObjectProperty
domain: NCIT C7057
range: NCIT C12913
IAO_0000115: A specializing role which may be used to override Disease_Has_Abnormal_Cell. The domain and the range for this role are 'Disease, Disorder or Finding' and 'Abnormal Cell', respectively.
NCIT NHC0: R139
NCIT P106: Conceptual Entity
NCIT P107: Excludes Abnormal Cell
NCIT P108: Disease_Excludes_Abnormal_Cell
has exact synonym: Disease_Excludes_Abnormal_Cell

Axiom
annotated source: Disease_Excludes_Abnormal_Cell
annotated property: IAO_0000115
annotated target: A specializing role which may be used to override Disease_Has_Abnormal_Cell. The domain and the range for this role are 'Disease, Disorder or Finding' and 'Abnormal Cell', respectively.
NCIT P378: NCI

Axiom
annotated source: Disease_Excludes_Abnormal_Cell
annotated property: hasExactSynonym
annotated target: Disease_Excludes_Abnormal_Cell
NCIT P383: PT
NCIT P384: NCI

Disease_Excludes_Molecular_Abnormality
type: ObjectProperty
domain: NCIT C7057
range: NCIT C3910
IAO_0000115: A specializing role which may be used to override Disease_Has_ Molecular_Abnormality. The domain and the range for this role are 'Disease, Disorder or Finding' and 'Molecular Abnormality', respectively.
NCIT NHC0: R140
NCIT P106: Conceptual Entity
NCIT P107: Excludes Molecular Abnormality
NCIT P108: Disease_Excludes_Molecular_Abnormality
has exact synonym: Disease_Excludes_Molecular_Abnormality

Axiom
annotated source: Disease_Excludes_Molecular_Abnormality
annotated property: IAO_0000115
annotated target: A specializing role which may be used to override Disease_Has_ Molecular_Abnormality. The domain and the range for this role are 'Disease, Disorder or Finding' and 'Molecular Abnormality', respectively.
NCIT P378: NCI

Axiom
annotated source: Disease_Excludes_Molecular_Abnormality
annotated property: hasExactSynonym
annotated target: Disease_Excludes_Molecular_Abnormality
NCIT P383: PT
NCIT P384: NCI

Disease_Excludes_Cytogenetic_Abnormality
type: ObjectProperty
domain: NCIT C7057
range: NCIT C3910
IAO_0000115: A specializing role which may be used to override Disease_Has_Cytogenetic_Abnormality. The domain and the range for this role are 'Disease, Disorder or Finding' and 'Molecular Abnormality', respectively.
NCIT NHC0: R141
NCIT P106: Conceptual Entity
NCIT P107: Excludes Cytogenetic Abnormality
NCIT P108: Disease_Excludes_Cytogenetic_Abnormality
has exact synonym: Disease_Excludes_Cytogenetic_Abnormality

Axiom
annotated source: Disease_Excludes_Cytogenetic_Abnormality
annotated property: IAO_0000115
annotated target: A specializing role which may be used to override Disease_Has_Cytogenetic_Abnormality. The domain and the range for this role are 'Disease, Disorder or Finding' and 'Molecular Abnormality', respectively.
NCIT P378: NCI

Axiom
annotated source: Disease_Excludes_Cytogenetic_Abnormality
annotated property: hasExactSynonym
annotated target: Disease_Excludes_Cytogenetic_Abnormality
NCIT P383: PT
NCIT P384: NCI

Disease_Excludes_Finding
type: ObjectProperty
domain: NCIT C7057
range: NCIT C7057
IAO_0000115: A specializing role which may be used to override Disease_Has_Finding. Both the domain and range for this role are 'Disease, Disorder or Finding'.
NCIT NHC0: R142
NCIT P106: Conceptual Entity
NCIT P107: Excludes Finding
NCIT P108: Disease_Excludes_Finding
has exact synonym: Disease_Excludes_Finding

Axiom
annotated source: Disease_Excludes_Finding
annotated property: IAO_0000115
annotated target: A specializing role which may be used to override Disease_Has_Finding. Both the domain and range for this role are 'Disease, Disorder or Finding'.
NCIT P378: NCI

Axiom
annotated source: Disease_Excludes_Finding
annotated property: hasExactSynonym
annotated target: Disease_Excludes_Finding
NCIT P383: PT
NCIT P384: NCI

Cytogenetic_Abnormality_Involves_Chromosome
type: ObjectProperty
domain: NCIT C2950
range: NCIT C13202
IAO_0000115: A role used to assert a direct relationship between a cytogenetic abnormality and a chromosome. The domain and range for this role are 'Cytogenetic Abnormality' and 'Chromosome', respectively. The range for this role excludes chromosomal bands and physical locations.
NCIT NHC0: R173
NCIT P106: Conceptual Entity
NCIT P108: Cytogenetic_Abnormality_Involves_Chromosome
has exact synonym: Cytogenetic_Abnormality_Involves_Chromosome

Axiom
annotated source: Cytogenetic_Abnormality_Involves_Chromosome
annotated property: IAO_0000115
annotated target: A role used to assert a direct relationship between a cytogenetic abnormality and a chromosome. The domain and range for this role are 'Cytogenetic Abnormality' and 'Chromosome', respectively. The range for this role excludes chromosomal bands and physical locations.
NCIT P378: NCI

Axiom
annotated source: Cytogenetic_Abnormality_Involves_Chromosome
annotated property: hasExactSynonym
annotated target: Cytogenetic_Abnormality_Involves_Chromosome
NCIT P383: PT
NCIT P384: NCI

Disease_Mapped_To_Chromosome
type: ObjectProperty
domain: NCIT C7057
range: NCIT C13202
IAO_0000115: A role used to assert a relationship between a disease, disorder or finding and a chromosome. This restriction should be used when a disease or disorder maps to a chromosome. It is not meant to be used when a specific cytogenetic abnormality is known (e.g. translocation, inversion). The domain and range for this role are 'Disease, Disorder or Finding' and 'Chromosome', respectively. The range for this role excludes chromosomal bands and physical locations.
NCIT NHC0: R174
NCIT P106: Conceptual Entity
NCIT P108: Disease_Mapped_To_Chromosome
has exact synonym: Disease_Mapped_To_Chromosome

Axiom
annotated source: Disease_Mapped_To_Chromosome
annotated property: IAO_0000115
annotated target: A role used to assert a relationship between a disease, disorder or finding and a chromosome. This restriction should be used when a disease or disorder maps to a chromosome. It is not meant to be used when a specific cytogenetic abnormality is known (e.g. translocation, inversion). The domain and range for this role are 'Disease, Disorder or Finding' and 'Chromosome', respectively. The range for this role excludes chromosomal bands and physical locations.
NCIT P378: NCI

Axiom
annotated source: Disease_Mapped_To_Chromosome
annotated property: hasExactSynonym
annotated target: Disease_Mapped_To_Chromosome
NCIT P383: PT
NCIT P384: NCI

Gene_Involved_In_Pathogenesis_Of_Disease
type: ObjectProperty
domain: NCIT C16612
range: NCIT C2991
IAO_0000115: A role used to assert a direct relationship between a gene and a disease. This restriction should only be used when an abnormality in a gene a causative event for a disease. The domain and range for this role are 'Gene' and 'Disease or Disorder', respectively.
NCIT NHC0: R175
NCIT P106: Conceptual Entity
NCIT P108: Gene_Involved_In_Pathogenesis_Of_Disease
has exact synonym: Gene_Involved_In_Pathogenesis_Of_Disease

Axiom
annotated source: Gene_Involved_In_Pathogenesis_Of_Disease
annotated property: IAO_0000115
annotated target: A role used to assert a direct relationship between a gene and a disease. This restriction should only be used when an abnormality in a gene a causative event for a disease. The domain and range for this role are 'Gene' and 'Disease or Disorder', respectively.
NCIT P378: NCI

Axiom
annotated source: Gene_Involved_In_Pathogenesis_Of_Disease
annotated property: hasExactSynonym
annotated target: Gene_Involved_In_Pathogenesis_Of_Disease
NCIT P383: PT
NCIT P384: NCI

Disease_Mapped_To_Gene
type: ObjectProperty
domain: NCIT C7057
range: NCIT C16612
IAO_0000115: A role used to assert a direct relationship between a disease, disorder or finding and a gene. This restriction can be used when a polymorphism or an abnormality in a gene is either a clinical marker for, a causative event for, or predisposes a subject to a disease. The domain and range for this role are 'Disease, Disorder or Finding' and 'Gene', respectively.
NCIT NHC0: R176
NCIT P106: Conceptual Entity
NCIT P108: Disease_Mapped_To_Gene
has exact synonym: Disease_Mapped_To_Gene

Axiom
annotated source: Disease_Mapped_To_Gene
annotated property: IAO_0000115
annotated target: A role used to assert a direct relationship between a disease, disorder or finding and a gene. This restriction can be used when a polymorphism or an abnormality in a gene is either a clinical marker for, a causative event for, or predisposes a subject to a disease. The domain and range for this role are 'Disease, Disorder or Finding' and 'Gene', respectively.
NCIT P378: NCI

Axiom
annotated source: Disease_Mapped_To_Gene
annotated property: hasExactSynonym
annotated target: Disease_Mapped_To_Gene
NCIT P383: PT
NCIT P384: NCI

Molecular_Abnormality_Involves_Gene
type: ObjectProperty
domain: NCIT C3910
range: NCIT C16612
IAO_0000115: A role used to assert a direct relationship between a molecular abnormality and a gene. The domain and range for this role are 'Molecular Abnormality' and 'Gene', respectively.
NCIT NHC0: R177
NCIT P106: Conceptual Entity
NCIT P108: Molecular_Abnormality_Involves_Gene
has exact synonym: Molecular_Abnormality_Involves_Gene

Axiom
annotated source: Molecular_Abnormality_Involves_Gene
annotated property: IAO_0000115
annotated target: A role used to assert a direct relationship between a molecular abnormality and a gene. The domain and range for this role are 'Molecular Abnormality' and 'Gene', respectively.
NCIT P378: NCI

Axiom
annotated source: Molecular_Abnormality_Involves_Gene
annotated property: hasExactSynonym
annotated target: Molecular_Abnormality_Involves_Gene
NCIT P383: PT
NCIT P384: NCI

Gene_Mutant_Encodes_Gene_Product_Sequence_Variation
type: ObjectProperty
domain: NCIT C97927
range: NCIT C97928
IAO_0000115: A role used to indicate that a specific molecular variation or mutation in a gene encodes a gene product sequence variant. The domain and range for this role are 'Gene Mutant' and 'Gene Product Sequence Variation', respectively.
NCIT NHC0: R178
NCIT P106: Conceptual Entity
NCIT P108: Gene_Mutant_Encodes_Gene_Product_Sequence_Variation
has exact synonym: Gene_Mutant_Encodes_Gene_Product_Sequence_Variation

Axiom
annotated source: Gene_Mutant_Encodes_Gene_Product_Sequence_Variation
annotated property: IAO_0000115
annotated target: A role used to indicate that a specific molecular variation or mutation in a gene encodes a gene product sequence variant. The domain and range for this role are 'Gene Mutant' and 'Gene Product Sequence Variation', respectively.
NCIT P378: NCI

Axiom
annotated source: Gene_Mutant_Encodes_Gene_Product_Sequence_Variation
annotated property: hasExactSynonym
annotated target: Gene_Mutant_Encodes_Gene_Product_Sequence_Variation
NCIT P383: PT
NCIT P384: NCI

Gene_Product_Sequence_Variation_Encoded_By_Gene_Mutant
type: ObjectProperty
domain: NCIT C97928
range: NCIT C97927
IAO_0000115: A role used to indicate that a gene product sequence variation is encoded by a specific gene mutant. The domain and range for this role are 'Gene Product Sequence Variation' and 'Gene Mutant', respectively.
NCIT NHC0: R179
NCIT P106: Conceptual Entity
NCIT P108: Gene_Product_Sequence_Variation_Encoded_By_Gene_Mutant
has exact synonym: Gene_Product_Sequence_Variation_Encoded_By_Gene_Mutant

Axiom
annotated source: Gene_Product_Sequence_Variation_Encoded_By_Gene_Mutant
annotated property: IAO_0000115
annotated target: A role used to indicate that a gene product sequence variation is encoded by a specific gene mutant. The domain and range for this role are 'Gene Product Sequence Variation' and 'Gene Mutant', respectively.
NCIT P378: NCI

Axiom
annotated source: Gene_Product_Sequence_Variation_Encoded_By_Gene_Mutant
annotated property: hasExactSynonym
annotated target: Gene_Product_Sequence_Variation_Encoded_By_Gene_Mutant
NCIT P383: PT
NCIT P384: NCI

Gene_Product_Variant_Of_Gene_Product
type: ObjectProperty
domain: NCIT C97928
range: NCIT C26548
IAO_0000115: A role used to indicate that a gene product sequence variation is related to a wild-type gene product. The domain and range for this role are 'Gene Product Sequence Variation' and 'Gene Product', respectively.
NCIT NHC0: R182
NCIT P106: Conceptual Entity
NCIT P108: Gene_Product_Variant_Of_Gene_Product
has exact synonym: Gene_Product_Variant_Of_Gene_Product

Axiom
annotated source: Gene_Product_Variant_Of_Gene_Product
annotated property: IAO_0000115
annotated target: A role used to indicate that a gene product sequence variation is related to a wild-type gene product. The domain and range for this role are 'Gene Product Sequence Variation' and 'Gene Product', respectively.
NCIT P378: NCI

Axiom
annotated source: Gene_Product_Variant_Of_Gene_Product
annotated property: hasExactSynonym
annotated target: Gene_Product_Variant_Of_Gene_Product
NCIT P383: PT
NCIT P384: NCI

Biological_Process_Has_Initiator_Process
type: ObjectProperty
domain: NCIT C17828
range: NCIT C17828
IAO_0000115: A role used to assert that the initiation of the stated biological process is dependent on the progression or completion of another process. The role implies a direct physical and functional interaction of an element from the preceding biological process with a target molecule or complex involved in the initial stages of the stated process. Both the domain and the range for this role are 'Biological Process'.
NCIT NHC0: R28
NCIT P106: Conceptual Entity
NCIT P107: Has Initiator Process
NCIT P108: Biological_Process_Has_Initiator_Process
has exact synonym: Biological_Process_Has_Initiator_Process

Axiom
annotated source: Biological_Process_Has_Initiator_Process
annotated property: IAO_0000115
annotated target: A role used to assert that the initiation of the stated biological process is dependent on the progression or completion of another process. The role implies a direct physical and functional interaction of an element from the preceding biological process with a target molecule or complex involved in the initial stages of the stated process. Both the domain and the range for this role are 'Biological Process'.
NCIT P378: NCI

Axiom
annotated source: Biological_Process_Has_Initiator_Process
annotated property: hasExactSynonym
annotated target: Biological_Process_Has_Initiator_Process
NCIT P383: PT
NCIT P384: NCI

Biological_Process_Has_Result_Chemical_Or_Drug
type: ObjectProperty
domain: NCIT C17828
range: NCIT C1908
IAO_0000115: A role used to assert that the endpoint of a biological process is the creation of a drug, chemical or biomedical material. The domain and range for this role are 'Biological Process' and 'Drug, Food, Chemical or Biomedical Material', respectively.
NCIT NHC0: R29
NCIT P106: Conceptual Entity
NCIT P107: Has Result Chemical Or Drug
NCIT P108: Biological_Process_Has_Result_Chemical_Or_Drug
has exact synonym: Biological_Process_Has_Result_Chemical_Or_Drug

Axiom
annotated source: Biological_Process_Has_Result_Chemical_Or_Drug
annotated property: IAO_0000115
annotated target: A role used to assert that the endpoint of a biological process is the creation of a drug, chemical or biomedical material. The domain and range for this role are 'Biological Process' and 'Drug, Food, Chemical or Biomedical Material', respectively.
NCIT P378: NCI

Axiom
annotated source: Biological_Process_Has_Result_Chemical_Or_Drug
annotated property: hasExactSynonym
annotated target: Biological_Process_Has_Result_Chemical_Or_Drug
NCIT P383: PT
NCIT P384: NCI

Biological_Process_Has_Associated_Location
type: ObjectProperty
domain: NCIT C17828
range: NCIT C12219
IAO_0000115: A role used to indicate the organ, organ system, cellular or subcellular location where a process occurs in a living system. The domain and range for this role are 'Biological Process' and 'Anatomic Structure, System, or Substance', respectively.
NCIT NHC0: R30
NCIT P106: Conceptual Entity
NCIT P107: Has Associated Location
NCIT P108: Biological_Process_Has_Associated_Location
has exact synonym: Biological_Process_Has_Associated_Location

Axiom
annotated source: Biological_Process_Has_Associated_Location
annotated property: IAO_0000115
annotated target: A role used to indicate the organ, organ system, cellular or subcellular location where a process occurs in a living system. The domain and range for this role are 'Biological Process' and 'Anatomic Structure, System, or Substance', respectively.
NCIT P378: NCI

Axiom
annotated source: Biological_Process_Has_Associated_Location
annotated property: hasExactSynonym
annotated target: Biological_Process_Has_Associated_Location
NCIT P383: PT
NCIT P384: NCI

Biological_Process_Has_Result_Anatomy
type: ObjectProperty
domain: NCIT C17828
range: NCIT C12219
IAO_0000115: A role used to assert that some biological event results in the formation of a subcellular complex, structure, cell, tissue or organ. This role is used to establish this relationship between the biological process and the anatomical factor formed. The domain and range for this role are 'Biological Process' and 'Anatomic Structure, System, or Substance', respectively.
NCIT NHC0: R31
NCIT P106: Conceptual Entity
NCIT P107: Has Result Anatomy
NCIT P108: Biological_Process_Has_Result_Anatomy
has exact synonym: Biological_Process_Has_Result_Anatomy

Axiom
annotated source: Biological_Process_Has_Result_Anatomy
annotated property: IAO_0000115
annotated target: A role used to assert that some biological event results in the formation of a subcellular complex, structure, cell, tissue or organ. This role is used to establish this relationship between the biological process and the anatomical factor formed. The domain and range for this role are 'Biological Process' and 'Anatomic Structure, System, or Substance', respectively.
NCIT P378: NCI

Axiom
annotated source: Biological_Process_Has_Result_Anatomy
annotated property: hasExactSynonym
annotated target: Biological_Process_Has_Result_Anatomy
NCIT P383: PT
NCIT P384: NCI

Biological_Process_Has_Initiator_Chemical_Or_Drug
type: ObjectProperty
domain: NCIT C17828
range: NCIT C1908
IAO_0000115: A role used to assert the relationship between a biological process and a drug or chemical that stimulates the process. The role implies the direct physical interaction of a chemical or drug with a target molecule or complex that results in the initiation of the process. The domain and range for this role are 'Biological Process' and 'Drug, Food, Chemical or Biomedical Material', respectively.
NCIT NHC0: R32
NCIT P106: Conceptual Entity
NCIT P107: Has Initiator Chemical Or Drug
NCIT P108: Biological_Process_Has_Initiator_Chemical_Or_Drug
has exact synonym: Biological_Process_Has_Initiator_Chemical_Or_Drug

Axiom
annotated source: Biological_Process_Has_Initiator_Chemical_Or_Drug
annotated property: IAO_0000115
annotated target: A role used to assert the relationship between a biological process and a drug or chemical that stimulates the process. The role implies the direct physical interaction of a chemical or drug with a target molecule or complex that results in the initiation of the process. The domain and range for this role are 'Biological Process' and 'Drug, Food, Chemical or Biomedical Material', respectively.
NCIT P378: NCI

Axiom
annotated source: Biological_Process_Has_Initiator_Chemical_Or_Drug
annotated property: hasExactSynonym
annotated target: Biological_Process_Has_Initiator_Chemical_Or_Drug
NCIT P383: PT
NCIT P384: NCI

Biological_Process_Has_Result_Biological_Process
type: ObjectProperty
domain: NCIT C17828
range: NCIT C17828
IAO_0000115: A role used to assert that the end result of a biological process initiates a subsequent biological process. Both the domain and the range for this role is 'Biological Process'.
NCIT NHC0: R34
NCIT P106: Conceptual Entity
NCIT P107: Has Result Biological Process
NCIT P108: Biological_Process_Has_Result_Biological_Process
has exact synonym: Biological_Process_Has_Result_Biological_Process

Axiom
annotated source: Biological_Process_Has_Result_Biological_Process
annotated property: IAO_0000115
annotated target: A role used to assert that the end result of a biological process initiates a subsequent biological process. Both the domain and the range for this role is 'Biological Process'.
NCIT P378: NCI

Axiom
annotated source: Biological_Process_Has_Result_Biological_Process
annotated property: hasExactSynonym
annotated target: Biological_Process_Has_Result_Biological_Process
NCIT P383: PT
NCIT P384: NCI

Biological_Process_Is_Part_Of_Process
type: ObjectProperty
domain: NCIT C17828
range: NCIT C17828
IAO_0000115: A role used to assert that a biological process operates as a component of another biological process. Both the domain and the range for this role is 'Biological Process'.
NCIT NHC0: R35
NCIT P106: Conceptual Entity
NCIT P107: Is Part Of Process
NCIT P108: Biological_Process_Is_Part_Of_Process
has exact synonym: Biological_Process_Is_Part_Of_Process

Axiom
annotated source: Biological_Process_Is_Part_Of_Process
annotated property: IAO_0000115
annotated target: A role used to assert that a biological process operates as a component of another biological process. Both the domain and the range for this role is 'Biological Process'.
NCIT P378: NCI

Axiom
annotated source: Biological_Process_Is_Part_Of_Process
annotated property: hasExactSynonym
annotated target: Biological_Process_Is_Part_Of_Process
NCIT P383: PT
NCIT P384: NCI

Gene_Plays_Role_In_Process
type: ObjectProperty
domain: NCIT C16612
range: NCIT C17828
IAO_0000115: A role used to assert a relationship between a gene and a biological process in which its encoded gene product(s) participate. The domain and range for this role are 'Gene' and 'Biological Process', respectively.
NCIT NHC0: R37
NCIT P106: Conceptual Entity
NCIT P107: Plays Role In Process
NCIT P108: Gene_Plays_Role_In_Process
has exact synonym: Gene_Plays_Role_In_Process

Axiom
annotated source: Gene_Plays_Role_In_Process
annotated property: IAO_0000115
annotated target: A role used to assert a relationship between a gene and a biological process in which its encoded gene product(s) participate. The domain and range for this role are 'Gene' and 'Biological Process', respectively.
NCIT P378: NCI

Axiom
annotated source: Gene_Plays_Role_In_Process
annotated property: hasExactSynonym
annotated target: Gene_Plays_Role_In_Process
NCIT P383: PT
NCIT P384: NCI

Gene_Associated_With_Disease
type: ObjectProperty
domain: NCIT C16612
range: NCIT C7057
IAO_0000115: A role used to indicate that molecular abnormalities in a gene may be associated with the manifestation of a disease. The role is used to assert a link between a gene and a disease when the association is considered to have clinical relevance. The domain and range for this role are 'Gene' and 'Disease, Disorder or Finding', respectively.
NCIT NHC0: R38
NCIT P106: Conceptual Entity
NCIT P107: Associated With Disease
NCIT P108: Gene_Associated_With_Disease
has exact synonym: Gene_Associated_With_Disease

Axiom
annotated source: Gene_Associated_With_Disease
annotated property: IAO_0000115
annotated target: A role used to indicate that molecular abnormalities in a gene may be associated with the manifestation of a disease. The role is used to assert a link between a gene and a disease when the association is considered to have clinical relevance. The domain and range for this role are 'Gene' and 'Disease, Disorder or Finding', respectively.
NCIT P378: NCI

Axiom
annotated source: Gene_Associated_With_Disease
annotated property: hasExactSynonym
annotated target: Gene_Associated_With_Disease
NCIT P383: PT
NCIT P384: NCI

Gene_Is_Biomarker_Of
type: ObjectProperty
domain: NCIT C16612
range: NCIT C7057
IAO_0000115: A role used to assert that expression or alteration of a gene is correlated with a particular disease or disease state or is predictive of the disease or disease state. The domain and range for this role are 'Gene' and Findings_and_Disorder_Kind, respectively.
NCIT NHC0: R39
NCIT P106: Conceptual Entity

Axiom
annotated source: Gene_Is_Biomarker_Of
annotated property: IAO_0000115
annotated target: A role used to assert that expression or alteration of a gene is correlated with a particular disease or disease state or is predictive of the disease or disease state. The domain and range for this role are 'Gene' and Findings_and_Disorder_Kind, respectively.
NCIT P378: NCI

Gene_In_Chromosomal_Location
type: ObjectProperty
domain: NCIT C16612
range: NCIT C12219
IAO_0000115: A role used to assert a relationship between a gene and its general location, specified by chromosomal band position (infrequently by chromosome number or chromosome arm). The domain and range for this role are 'Gene' and 'Anatomic Structure, System, or Substance', respectively.
NCIT NHC0: R40
NCIT P106: Conceptual Entity
NCIT P107: In Chromosomal Location
NCIT P108: Gene_In_Chromosomal_Location
has exact synonym: Gene_In_Chromosomal_Location

Axiom
annotated source: Gene_In_Chromosomal_Location
annotated property: IAO_0000115
annotated target: A role used to assert a relationship between a gene and its general location, specified by chromosomal band position (infrequently by chromosome number or chromosome arm). The domain and range for this role are 'Gene' and 'Anatomic Structure, System, or Substance', respectively.
NCIT P378: NCI

Axiom
annotated source: Gene_In_Chromosomal_Location
annotated property: hasExactSynonym
annotated target: Gene_In_Chromosomal_Location
NCIT P383: PT
NCIT P384: NCI

Gene_Found_In_Organism
type: ObjectProperty
domain: NCIT C16612
range: NCIT C14250
IAO_0000115: A role used to specify the organism of origin for a gene. It may be used to differentiate genes with the same name and functions that originate from different organisms. The domain and range for this role are 'Gene' and 'Organism', respectively.
NCIT NHC0: R41
NCIT P106: Conceptual Entity
NCIT P107: Found In Organism
NCIT P108: Gene_Found_In_Organism
NCIT P98: Currently, we only model human genes, but this role has obvious utility in future, if other organisms are modeled as well.
has exact synonym: Gene_Found_In_Organism

Axiom
annotated source: Gene_Found_In_Organism
annotated property: IAO_0000115
annotated target: A role used to specify the organism of origin for a gene. It may be used to differentiate genes with the same name and functions that originate from different organisms. The domain and range for this role are 'Gene' and 'Organism', respectively.
NCIT P378: NCI

Axiom
annotated source: Gene_Found_In_Organism
annotated property: hasExactSynonym
annotated target: Gene_Found_In_Organism
NCIT P383: PT
NCIT P384: NCI

Gene_Product_Is_Biomarker_Type
type: ObjectProperty
domain: NCIT C26548
range: NCIT C20047
IAO_0000115: A role used to designate the type of biomarker a gene product is; it points to a small tree of biomarker types (e.g., Disease Marker, Metabolic Marker, Prognostic Marker). The domain and range for this role are 'Gene Product' and 'Diagnostic or Prognostic Factor', respectively.
NCIT NHC0: R42
NCIT P106: Conceptual Entity
NCIT P107: Is Biomarker Type
NCIT P108: Gene_Product_Is_Biomarker_Type
has exact synonym: Gene_Product_Is_Biomarker_Type

Axiom
annotated source: Gene_Product_Is_Biomarker_Type
annotated property: IAO_0000115
annotated target: A role used to designate the type of biomarker a gene product is; it points to a small tree of biomarker types (e.g., Disease Marker, Metabolic Marker, Prognostic Marker). The domain and range for this role are 'Gene Product' and 'Diagnostic or Prognostic Factor', respectively.
NCIT P378: NCI

Axiom
annotated source: Gene_Product_Is_Biomarker_Type
annotated property: hasExactSynonym
annotated target: Gene_Product_Is_Biomarker_Type
NCIT P383: PT
NCIT P384: NCI

Gene_Product_Has_Chemical_Classification
type: ObjectProperty
domain: NCIT C26548
range: NCIT C26548
IAO_0000115: A role used to specify the physical structure type of a protein molecule (e.g. metalloprotein, transmembrane protein). Both the domain and range for this role are 'Gene Product'.
NCIT NHC0: R44
NCIT P106: Conceptual Entity
NCIT P107: Has Chemical Classification
NCIT P108: Gene_Product_Has_Chemical_Classification
NCIT P98: The role was originally intended for protein structure tagging (e.g., Phosphoprotein, Lipoprotein). Was extended to also tag for Membrane Protein, Protein Complex Subunit, etc.
has exact synonym: Gene_Product_Has_Chemical_Classification

Axiom
annotated source: Gene_Product_Has_Chemical_Classification
annotated property: IAO_0000115
annotated target: A role used to specify the physical structure type of a protein molecule (e.g. metalloprotein, transmembrane protein). Both the domain and range for this role are 'Gene Product'.
NCIT P378: NCI

Axiom
annotated source: Gene_Product_Has_Chemical_Classification
annotated property: hasExactSynonym
annotated target: Gene_Product_Has_Chemical_Classification
NCIT P383: PT
NCIT P384: NCI

Gene_Product_Has_Organism_Source
type: ObjectProperty
domain: NCIT C26548
range: NCIT C14250
IAO_0000115: A role used to differentiate homologous proteins from different organisms. The domain and range for this role are 'Gene Product' and 'Organism', respectively.
NCIT NHC0: R45
NCIT P106: Conceptual Entity
NCIT P107: Has Organism Source
NCIT P108: Gene_Product_Has_Organism_Source
has exact synonym: Gene_Product_Has_Organism_Source

Axiom
annotated source: Gene_Product_Has_Organism_Source
annotated property: IAO_0000115
annotated target: A role used to differentiate homologous proteins from different organisms. The domain and range for this role are 'Gene Product' and 'Organism', respectively.
NCIT P378: NCI

Axiom
annotated source: Gene_Product_Has_Organism_Source
annotated property: hasExactSynonym
annotated target: Gene_Product_Has_Organism_Source
NCIT P383: PT
NCIT P384: NCI

Gene_Product_Has_Associated_Anatomy
type: ObjectProperty
domain: NCIT C26548
range: NCIT C12219
IAO_0000115: A role used to specify physical structures or typical subcellular locations of a gene product. The domain and range for this role are 'Gene Product' and 'Anatomic Structure, System, or Substance', respectively.
NCIT NHC0: R46
NCIT P106: Conceptual Entity
NCIT P107: Has Associated Anatomy
NCIT P108: Gene_Product_Has_Associated_Anatomy
has exact synonym: Gene_Product_Has_Associated_Anatomy

Axiom
annotated source: Gene_Product_Has_Associated_Anatomy
annotated property: IAO_0000115
annotated target: A role used to specify physical structures or typical subcellular locations of a gene product. The domain and range for this role are 'Gene Product' and 'Anatomic Structure, System, or Substance', respectively.
NCIT P378: NCI

Axiom
annotated source: Gene_Product_Has_Associated_Anatomy
annotated property: hasExactSynonym
annotated target: Gene_Product_Has_Associated_Anatomy
NCIT P383: PT
NCIT P384: NCI

Gene_Product_Malfunction_Associated_With_Disease
type: ObjectProperty
domain: NCIT C26548
range: NCIT C7057
IAO_0000115: A role used to indicate that molecular abnormalities in a gene product may be associated with the manifestation of a disease. The role is used to assert a link between a gene product and a disease when the association is considered to have clinical relevance. The domain and range for this role are 'Gene Product' and 'Disease, Disorder or Finding', respectively.
NCIT NHC0: R48
NCIT P106: Conceptual Entity
NCIT P107: Malfunction Associated With Disease
NCIT P108: Gene_Product_Malfunction_Associated_With_Disease
has exact synonym: Gene_Product_Malfunction_Associated_With_Disease

Axiom
annotated source: Gene_Product_Malfunction_Associated_With_Disease
annotated property: IAO_0000115
annotated target: A role used to indicate that molecular abnormalities in a gene product may be associated with the manifestation of a disease. The role is used to assert a link between a gene product and a disease when the association is considered to have clinical relevance. The domain and range for this role are 'Gene Product' and 'Disease, Disorder or Finding', respectively.
NCIT P378: NCI

Axiom
annotated source: Gene_Product_Malfunction_Associated_With_Disease
annotated property: hasExactSynonym
annotated target: Gene_Product_Malfunction_Associated_With_Disease
NCIT P383: PT
NCIT P384: NCI

Gene_Product_Expressed_In_Tissue
type: ObjectProperty
domain: NCIT C26548
range: NCIT C12219
IAO_0000115: A role used to specify that a normal tissue is the normal location for the expression of a gene product. The domain and range for this role are 'Gene Product' and 'Anatomic Structure, System, or Substance', respectively.
NCIT NHC0: R49
NCIT P106: Conceptual Entity
NCIT P107: Expressed In Tissue
NCIT P108: Gene_Product_Expressed_In_Tissue
NCIT P98: This information is often useful to researchers. However, we no longer curate this information and now favor linking out to externally curated databases. Source database for the link has yet to be decided.
has exact synonym: Gene_Product_Expressed_In_Tissue

Axiom
annotated source: Gene_Product_Expressed_In_Tissue
annotated property: IAO_0000115
annotated target: A role used to specify that a normal tissue is the normal location for the expression of a gene product. The domain and range for this role are 'Gene Product' and 'Anatomic Structure, System, or Substance', respectively.
NCIT P378: NCI

Axiom
annotated source: Gene_Product_Expressed_In_Tissue
annotated property: hasExactSynonym
annotated target: Gene_Product_Expressed_In_Tissue
NCIT P383: PT
NCIT P384: NCI

Gene_Product_Has_Structural_Domain_Or_Motif
type: ObjectProperty
domain: NCIT C26548
range: NCIT C12219
IAO_0000115: A role used specify information about protein domains or motifs present in a protein that can give insight into protein function. The domain and range for this role are 'Gene Product' and 'Anatomic Structure, System, or Substance', respectively.
NCIT NHC0: R50
NCIT P106: Conceptual Entity
NCIT P107: Has Structural Domain Or Motif
NCIT P108: Gene_Product_Has_Structural_Domain_Or_Motif
NCIT P98: We no longer curate this information and now favor linking out to externally curated databases. The source database for the link has yet to be decided.
has exact synonym: Gene_Product_Has_Structural_Domain_Or_Motif

Axiom
annotated source: Gene_Product_Has_Structural_Domain_Or_Motif
annotated property: IAO_0000115
annotated target: A role used specify information about protein domains or motifs present in a protein that can give insight into protein function. The domain and range for this role are 'Gene Product' and 'Anatomic Structure, System, or Substance', respectively.
NCIT P378: NCI

Axiom
annotated source: Gene_Product_Has_Structural_Domain_Or_Motif
annotated property: hasExactSynonym
annotated target: Gene_Product_Has_Structural_Domain_Or_Motif
NCIT P383: PT
NCIT P384: NCI

Gene_Product_Is_Physical_Part_Of
type: ObjectProperty
domain: NCIT C26548
range: NCIT C26548
IAO_0000115: A role used to indicate that a gene product normally functions as a component of a "functional complex". Both the domain and range for this role are 'Gene Product'.
NCIT NHC0: R51
NCIT P106: Conceptual Entity
NCIT P107: Is Physical Part Of
NCIT P108: Gene_Product_Is_Physical_Part_Of
has exact synonym: Gene_Product_Is_Physical_Part_Of

Axiom
annotated source: Gene_Product_Is_Physical_Part_Of
annotated property: IAO_0000115
annotated target: A role used to indicate that a gene product normally functions as a component of a "functional complex". Both the domain and range for this role are 'Gene Product'.
NCIT P378: NCI

Axiom
annotated source: Gene_Product_Is_Physical_Part_Of
annotated property: hasExactSynonym
annotated target: Gene_Product_Is_Physical_Part_Of
NCIT P383: PT
NCIT P384: NCI

Gene_Product_Has_Biochemical_Function
type: ObjectProperty
domain: NCIT C26548
range: NCIT C26548
IAO_0000115: A role used to denote the biochemical activity of a gene product. Both the domain and range for this role are 'Gene Product'.
NCIT NHC0: R52
NCIT P106: Conceptual Entity
NCIT P107: Has Biochemical Function
NCIT P108: Gene_Product_Has_Biochemical_Function
has exact synonym: Gene_Product_Has_Biochemical_Function

Axiom
annotated source: Gene_Product_Has_Biochemical_Function
annotated property: IAO_0000115
annotated target: A role used to denote the biochemical activity of a gene product. Both the domain and range for this role are 'Gene Product'.
NCIT P378: NCI

Axiom
annotated source: Gene_Product_Has_Biochemical_Function
annotated property: hasExactSynonym
annotated target: Gene_Product_Has_Biochemical_Function
NCIT P383: PT
NCIT P384: NCI

Gene_Product_Plays_Role_In_Biological_Process
type: ObjectProperty
domain: NCIT C26548
range: NCIT C17828
IAO_0000115: A role used to assert that a gene product participates in a specific biological process. The domain and range for this role are 'Gene Product' and 'Biological Process', respectively.
NCIT NHC0: R53
NCIT P106: Conceptual Entity
NCIT P107: Plays Role In Biological Process
NCIT P108: Gene_Product_Plays_Role_In_Biological_Process
NCIT P98: Considered by most researchers to be essential, definitional information about a gene product.
has exact synonym: Gene_Product_Plays_Role_In_Biological_Process

Axiom
annotated source: Gene_Product_Plays_Role_In_Biological_Process
annotated property: IAO_0000115
annotated target: A role used to assert that a gene product participates in a specific biological process. The domain and range for this role are 'Gene Product' and 'Biological Process', respectively.
NCIT P378: NCI

Axiom
annotated source: Gene_Product_Plays_Role_In_Biological_Process
annotated property: hasExactSynonym
annotated target: Gene_Product_Plays_Role_In_Biological_Process
NCIT P383: PT
NCIT P384: NCI

Gene_Product_Encoded_By_Gene
type: ObjectProperty
domain: NCIT C26548
range: NCIT C16612
IAO_0000115: A role used to assert a relationship between a gene product and the gene that encodes it. The domain and range for this role are 'Gene Product' and 'Gene', respectively.
NCIT NHC0: R54
NCIT P106: Conceptual Entity
NCIT P107: Encoded By Gene
NCIT P108: Gene_Product_Encoded_By_Gene
NCIT P98: The reciprocal relationship is represented in the property Gene_Encodes_Product
has exact synonym: Gene_Product_Encoded_By_Gene

Axiom
annotated source: Gene_Product_Encoded_By_Gene
annotated property: IAO_0000115
annotated target: A role used to assert a relationship between a gene product and the gene that encodes it. The domain and range for this role are 'Gene Product' and 'Gene', respectively.
NCIT P378: NCI

Axiom
annotated source: Gene_Product_Encoded_By_Gene
annotated property: hasExactSynonym
annotated target: Gene_Product_Encoded_By_Gene
NCIT P383: PT
NCIT P384: NCI

Anatomic_Structure_Has_Location
type: ObjectProperty
type: TransitiveProperty
domain: NCIT C12219
range: NCIT C12219
IAO_0000115: A role used to indicate the physical location of an anatomic structure in the body. Both the domain and range for this role are 'Anatomic Structure, System, or Substance'.
NCIT NHC0: R81
NCIT P106: Conceptual Entity
NCIT P107: Has Location
NCIT P108: Anatomic_Structure_Has_Location
has exact synonym: Anatomic_Structure_Has_Location

Axiom
annotated source: Anatomic_Structure_Has_Location
annotated property: IAO_0000115
annotated target: A role used to indicate the physical location of an anatomic structure in the body. Both the domain and range for this role are 'Anatomic Structure, System, or Substance'.
NCIT P378: NCI

Axiom
annotated source: Anatomic_Structure_Has_Location
annotated property: hasExactSynonym
annotated target: Anatomic_Structure_Has_Location
NCIT P383: PT
NCIT P384: NCI

Anatomic_Structure_Is_Physical_Part_Of
type: ObjectProperty
type: TransitiveProperty
domain: NCIT C12219
range: NCIT C12219
IAO_0000115: A role used to indicate that an anatomic structure has a physical association with a broader system or organ. Both the domain and range for this role are 'Anatomic Structure, System, or Substance'.
NCIT NHC0: R82
NCIT P106: Conceptual Entity
NCIT P107: Is Physical Part Of
NCIT P108: Anatomic_Structure_Is_Physical_Part_Of
has exact synonym: Anatomic_Structure_Is_Physical_Part_Of

Axiom
annotated source: Anatomic_Structure_Is_Physical_Part_Of
annotated property: IAO_0000115
annotated target: A role used to indicate that an anatomic structure has a physical association with a broader system or organ. Both the domain and range for this role are 'Anatomic Structure, System, or Substance'.
NCIT P378: NCI

Axiom
annotated source: Anatomic_Structure_Is_Physical_Part_Of
annotated property: hasExactSynonym
annotated target: Anatomic_Structure_Is_Physical_Part_Of
NCIT P383: PT
NCIT P384: NCI

Disease_Is_Stage
type: ObjectProperty
domain: NCIT C7057
range: NCIT C20189
IAO_0000115: A role used to specify the disease stage of a disease, the extent to which a cancer has spread from the original site to other parts of the body. The domain and the range for this role are 'Disease, Disorder or Finding' and 'Property or_Attribute', respectively.
NCIT NHC0: R88
NCIT P106: Conceptual Entity
NCIT P107: Is Stage
NCIT P108: Disease_Is_Stage
has exact synonym: Disease_Is_Stage

Axiom
annotated source: Disease_Is_Stage
annotated property: IAO_0000115
annotated target: A role used to specify the disease stage of a disease, the extent to which a cancer has spread from the original site to other parts of the body. The domain and the range for this role are 'Disease, Disorder or Finding' and 'Property or_Attribute', respectively.
NCIT P378: NCI

Axiom
annotated source: Disease_Is_Stage
annotated property: hasExactSynonym
annotated target: Disease_Is_Stage
NCIT P383: PT
NCIT P384: NCI

Disease_May_Have_Molecular_Abnormality
type: ObjectProperty
domain: NCIT C7057
range: NCIT C3910
IAO_0000115: A role used to represent that a molecular abnormality will only be present in some cases of the disease. The domain and the range for this role are 'Disease, Disorder or Finding' and 'Molecular Abnormality', respectively.
NCIT NHC0: R89
NCIT P106: Conceptual Entity
NCIT P107: May Have Molecular Abnormality
NCIT P108: Disease_May_Have_Molecular_Abnormality
has exact synonym: Disease_May_Have_Molecular_Abnormality

Axiom
annotated source: Disease_May_Have_Molecular_Abnormality
annotated property: IAO_0000115
annotated target: A role used to represent that a molecular abnormality will only be present in some cases of the disease. The domain and the range for this role are 'Disease, Disorder or Finding' and 'Molecular Abnormality', respectively.
NCIT P378: NCI

Axiom
annotated source: Disease_May_Have_Molecular_Abnormality
annotated property: hasExactSynonym
annotated target: Disease_May_Have_Molecular_Abnormality
NCIT P383: PT
NCIT P384: NCI

inheres in
type: ObjectProperty
inverse of: bearer of
IAO_0000115: a relation between a specifically dependent continuant (the dependent) and an independent continuant (the bearer), in which the dependent specifically depends on the bearer for its existence

bearer of
type: ObjectProperty
range: BFO_0000020
IAO_0000115: a relation between an independent continuant (the bearer) and a specifically dependent continuant (the dependent), in which the dependent specifically depends on the bearer for its existence
database_cross_reference: RO:0000053
has OBO namespace: uberon
id: bearer_of
shorthand: bearer_of

participates in
type: ObjectProperty
inverse of: has participant
domain: BFO_0000002
range: BFO_0000003
IAO_0000115: a relation between a continuant and a process, in which the continuant is somehow involved in the process

has participant
type: ObjectProperty
domain: BFO_0000003
range: BFO_0000002
property chain axiom: has_part
IAO_0000115: a relation between a process and a continuant, in which the continuant is somehow involved in the process

quality of
type: ObjectProperty
sub property of: inheres in
inverse of: has quality
IAO_0000115: a relation between a quality and an independent continuant (the bearer), in which the quality specifically depends on the bearer for its existence

has quality
type: ObjectProperty
sub property of: bearer of
range: BFO_0000019
IAO_0000115: a relation between an independent continuant (the bearer) and a quality, in which the quality specifically depends on the bearer for its existence
database_cross_reference: RO:0000086
has OBO namespace: uberon
id: has_quality
shorthand: has_quality

location_of
type: ObjectProperty
inverse of: located_in
type: TransitiveProperty
IAO_0000115: a relation between two independent continuants, the location and the target, in which the target is entirely within the location
database_cross_reference: RO:0001015
has OBO namespace: uberon
id: location_of
shorthand: location_of
label: location of

contained in
type: ObjectProperty
inverse of: contains
domain: material entity
range: BFO_0000004
property chain axiom: located_in
property chain axiom: part_of

contains
type: ObjectProperty
database_cross_reference: RO:0001019
has OBO namespace: uberon
id: contains
shorthand: contains

located_in
type: ObjectProperty
type: TransitiveProperty
IAO_0000115: a relation between two independent continuants, the target and the location, in which the target is entirely within the location
database_cross_reference: RO:0001025
has OBO namespace: uberon
id: located_in
shorthand: located_in
label: located in

boundary of
type: ObjectProperty
inverse of: has boundary
IAO_0000115: a relation between a 2D immaterial entity (the boundary) and a material entity, in which the boundary delimits the material entity
database_cross_reference: RO:0002000
has OBO namespace: uberon
id: boundary_of
shorthand: boundary_of
label: 2D boundary of

has boundary
type: ObjectProperty
domain: material entity
range: BFO_0000141
IAO_0000115: a relation between a material entity and a 2D immaterial entity (the boundary), in which the boundary delimits the material entity
database_cross_reference: RO:0002002
has OBO namespace: uberon
id: has_boundary
shorthand: has_boundary
label: has 2D boundary

innervated_by
type: ObjectProperty
inverse of: innervates
property chain axiom: branching_part_of
database_cross_reference: RO:0002005
has exact synonym: nerve supply
has OBO namespace: uberon
id: innervated_by
shorthand: innervated_by
comment: http://code.google.com/p/obo-relations/issues/detail

Axiom
annotated source: innervated_by
annotated property: hasExactSynonym
annotated target: nerve supply
database_cross_reference: FMA:85999

bounding layer of
type: ObjectProperty
sub property of: part_of
domain: Class
  intersection of: material entity
  intersection of: Restriction
    on property: bearer of
    some values from: PATO_0002124
range: material entity
IAO_0000115: X outer_layer_of Y iff: . X :continuant that bearer_of some PATO:laminar . X part_of Y . exists Z :surface . X has_boundary Z . Z boundary_of Y has_boundary: http://purl.obolibrary.org/obo/RO_0002002 boundary_of: http://purl.obolibrary.org/obo/RO_0002000
database_cross_reference: RO:0002007
has OBO namespace: uberon
id: bounding_layer_of
shorthand: bounding_layer_of
comment: A relationship that applies between a continuant and its outer, bounding layer. Examples include the relationship between a multicellular organism and its integument, between an animal cell and its plasma membrane, and between a membrane bound organelle and its outer/bounding membrane.

before or simultaneous with
type: ObjectProperty
sub property of: temporally related to

simultaneous_with
type: ObjectProperty
sub property of: before or simultaneous with
sub property of: starts
sub property of: ends
type: TransitiveProperty
IAO_0000115: Relation between occurrents, shares start and end boundaries.
database_cross_reference: RO:0002082
has exact synonym: coincides_with
has exact synonym: is_equal_to
has OBO namespace: uberon
id: simultaneous_with
shorthand: simultaneous_with
label: simultaneous with

Axiom
annotated source: simultaneous_with
annotated property: IAO_0000115
annotated target: Relation between occurrents, shares start and end boundaries.
database_cross_reference: https://orcid.org/0000-0002-6601-2165
database_cross_reference: Allen:is_equal_to

ends after
type: ObjectProperty
sub property of: temporally related to
type: TransitiveProperty

immediately_preceded_by
type: ObjectProperty
sub property of: preceded_by
inverse of: immediately precedes
property chain axiom: starts with
property chain axiom: ends with
IAO_0000115: X immediately_preceded_by Y iff: end(X) simultaneous_with start(Y)
UBPROP_0000001: A non-transitive temporal relation in which one process immediately precedes another process, such that there is no interval of time between the two processes[SIO:000251].
database_cross_reference: RO:0002087
has exact synonym: directly preceded by
has exact synonym: is directly preceded by
has exact synonym: is immediately preceded by
has exact synonym: starts_at_end_of
has OBO namespace: uberon
id: immediately_preceded_by
shorthand: immediately_preceded_by
label: immediately preceded by

Axiom
annotated source: immediately_preceded_by
annotated property: UBPROP_0000001
annotated target: A non-transitive temporal relation in which one process immediately precedes another process, such that there is no interval of time between the two processes[SIO:000251].
source: SIO:000251

Axiom
annotated source: immediately_preceded_by
annotated property: hasExactSynonym
annotated target: is immediately preceded by
database_cross_reference: SIO:000251

immediately precedes
type: ObjectProperty
sub property of: precedes
property chain axiom: ends with
property chain axiom: starts with

synapsed by
type: ObjectProperty
inverse of: synapsed to
range: Class
  union of: neuron
  union of: Restriction
    on property: part_of
    some values from: neuron
IAO_0000115: Relation between an anatomical structure (including cells) and a neuron that chemically synapses to it.
database_cross_reference: RO:0002103
has OBO namespace: uberon
id: synapsed_by
shorthand: synapsed_by

synapsed to
type: ObjectProperty
domain: Class
  union of: neuron
  union of: Restriction
    on property: part_of
    some values from: neuron
IAO_0000115: Relation between a neuron and an anatomical structure (including cells) that it chemically synapses to.

innervates
type: ObjectProperty
domain: CARO_0001001
property chain axiom: part_of
IAO_0000115: Relation between a 'neuron projection bundle' and a region in which one or more of its component neuron projections either synapses to targets or receives synaptic input. T innervates some R Expands_to: T has_fasciculating_neuron_projection that synapse_in some R.
database_cross_reference: RO:0002134
has OBO namespace: uberon
id: innervates
shorthand: innervates
comment: http://code.google.com/p/obo-relations/issues/detail

continuous_with
type: ObjectProperty
type: SymmetricProperty
domain: BFO_0000004
range: BFO_0000004
IAO_0000115: X continuous_with Y if and only if X and Y share a fiat boundary.
database_cross_reference: RO:0002150
has OBO namespace: uberon
id: continuous_with
shorthand: continuous_with
label: continuous with

homologous_to
type: ObjectProperty
database_cross_reference: RO:0002158
has OBO namespace: uberon
id: homologous_to
shorthand: homologous_to

only in taxon
type: ObjectProperty
sub property of: in taxon
IAO_0000115: S only_in_taxon T iff: S SubClassOf in_taxon only T
IAO_0000115: x only in taxon y if and only if x is in taxon y, and there is no other organism z such that y!=z a and x is in taxon z.
database_cross_reference: RO:0002160
has OBO namespace: uberon
id: only_in_taxon
shorthand: only_in_taxon
label: only_in_taxon

Axiom
annotated source: only in taxon
annotated property: IAO_0000115
annotated target: S only_in_taxon T iff: S SubClassOf in_taxon only T
database_cross_reference: http://www.ncbi.nlm.nih.gov/pubmed/20973947

in taxon
type: ObjectProperty
range: BFO_0000004
property chain axiom: part_of
property chain axiom: has_part
property chain axiom: innervated_by
property chain axiom: continuous_with
property chain axiom: connected to
property chain axiom: connects
property chain axiom: supplies
property chain axiom: develops_from
property chain axiom: capable of
property chain axiom: develops_from_part_of
property chain axiom: has developmental contribution from
property chain axiom: developmentally_induced_by
property chain axiom: attaches_to
property chain axiom: has potential to develop into
property chain axiom: existence starts during
property chain axiom: existence ends during
property chain axiom: produces
property chain axiom: produced_by
property chain axiom: extends_fibers_into
IAO_0000115: x is in taxon y if an only if y is an organism, and the relationship between x and y is one of: part of (reflexive), developmentally preceded by, derives from, secreted by, expressed.
database_cross_reference: RO:0002162
has OBO namespace: uberon
id: in_taxon
shorthand: in_taxon

connected to
type: ObjectProperty
sub property of: transitively_connected to
domain: Restriction
  on property: part_of
  some values from: RO_0002577
range: Restriction
  on property: part_of
  some values from: RO_0002577
property chain axiom:
  inverse of: connects
property chain axiom: connects
IAO_0000115: Binary relationship: x connected_to y if and only if there exists some z such that z connects x and y in a ternary connected_to(x,y,z) relationship.
IAO_0000115: a is connected to b if and only if a and b are discrete structure, and there exists some connecting structure c, such that c connects a and b
database_cross_reference: RO:0002170
has OBO namespace: uberon
id: connected_to
shorthand: connected_to
comment: Connection does not imply overlaps.

Axiom
annotated source: connected to
annotated property: IAO_0000115
annotated target: Binary relationship: x connected_to y if and only if there exists some z such that z connects x and y in a ternary connected_to(x,y,z) relationship.
database_cross_reference: Connectivity-Design-Pattern

connects
type: ObjectProperty
domain: BFO_0000004
range: Restriction
  on property: part_of
  some values from: RO_0002577
IAO_0000115: Binary relationship: z connects x if and only if there exists some y such that z connects x and y in a ternary connected_to(x,y,z) relationship.
IAO_0000115: c connects a if and only if there exist some b such that a and b are similar parts of the same system, and c connects b, specifically, c connects a with b. When one structure connects two others it unites some aspect of the function or role they play within the system.
IAO_0000116: this is currently used for both structural relationships (such as between a valve and the chamber it connects) and abstract relationships (anatomical lines and the entities they connect)
database_cross_reference: RO:0002176
has OBO namespace: uberon
id: connects
shorthand: connects

Axiom
annotated source: connects
annotated property: IAO_0000115
annotated target: Binary relationship: z connects x if and only if there exists some y such that z connects x and y in a ternary connected_to(x,y,z) relationship.
database_cross_reference: Connectivity-Design-Pattern

attaches_to_part_of
type: ObjectProperty
sub property of: biomechanically related to
domain: material entity
range: material entity
property chain axiom: attaches_to
property chain axiom: part_of
IAO_0000115: a is attached to part of b if a is attached to b, or a is attached to some p, where p is part of b.
database_cross_reference: RO:0002177
has OBO namespace: uberon
id: attaches_to_part_of
shorthand: attaches_to_part_of
label: attached to part of

Axiom
annotated source: attaches_to_part_of
annotated property: propertyChainAxiom
annotated target: attaches_to
annotated target: part_of
IAO is reversible property chain: true

Axiom
annotated source: attaches_to_part_of
annotated property: propertyChainAxiom
annotated target: attaches_to
annotated target: part_of
RO_0002582: true

supplies
type: ObjectProperty
sub property of: connected to
IAO_0000115: Relation between an arterial structure and another structure, where the arterial structure acts as a conduit channeling fluid, substance or energy.
IAO_0000115: relation between an artery and the structure is supplies with blood.
database_cross_reference: RO:0002178
has exact synonym: arterial supply of
has OBO namespace: uberon
id: supplies
shorthand: supplies
comment: source: FMA

Axiom
annotated source: supplies
annotated property: hasExactSynonym
annotated target: arterial supply of
database_cross_reference: FMA:86003

drains
type: ObjectProperty
sub property of: connected to
IAO_0000115: Relation between an collecting structure and another structure, where the collecting structure acts as a conduit channeling fluid, substance or energy away from the other structure.
database_cross_reference: RO:0002179
has exact synonym: drains blood from
has exact synonym: drains from
has OBO namespace: uberon
id: drains
shorthand: drains
comment: source: Wikipedia

has component
type: ObjectProperty
sub property of: has_part
IAO_0000115: w 'has component' p if w 'has part' p and w is such that it can be directly disassembled into into n parts p, p2, p3, ..., pn, where these parts are of similar type.
database_cross_reference: RO:0002180
has OBO namespace: uberon
id: has_component
shorthand: has_component

develops_from
type: ObjectProperty
sub property of: has developmental contribution from
sub property of: developmentally preceded by
inverse of: develops_into
type: TransitiveProperty
domain: BFO_0000004
range: BFO_0000004
property chain axiom: part_of
IAO_0000115: x develops from y if and only if either (a) x directly develops from y or (b) there exists some z such that x directly develops from z and z develops from y
database_cross_reference: RO:0002202
has OBO namespace: uberon
id: develops_from
shorthand: develops_from
label: develops from

develops_into
type: ObjectProperty
sub property of: developmentally succeeded by
sub property of: has potential to develop into
sub property of: has potential to directly develop into
type: TransitiveProperty
IAO_0000115: inverse of develops from
database_cross_reference: RO:0002203
has OBO namespace: uberon
id: develops_into
shorthand: develops_into
label: develops into

directly_develops_from
type: ObjectProperty
sub property of: develops_from
inverse of: directly develops into
domain: Class
  union of: CARO_0010000
  union of: cell
range: Class
  union of: CARO_0010000
  union of: cell
IAO_0000115: Candidate definition: x directly_develops from y if and only if there exists some developmental process (GO:0032502) p such that x and y both participates in p, and x is the output of p and y is the input of p, and a substantial portion of the matter of y comes from x, and the start of x is coincident with or after the end of y
database_cross_reference: RO:0002207
has OBO namespace: uberon
id: directly_develops_from
shorthand: directly_develops_from
label: directly develops from

directly develops into
type: ObjectProperty
sub property of: develops_into
IAO_0000115: inverse of directly develops from

regulates
type: ObjectProperty
sub property of: causally upstream of
inverse of: regulated by
type: TransitiveProperty
domain: BFO_0000015
range: BFO_0000015
property chain axiom: ends with
property chain axiom: directly regulates
IAO_0000115: process(P1) regulates process(P2) iff: P1 results in the initiation or termination of P2 OR affects the frequency of its initiation or termination OR affects the magnitude or rate of output of P2.
database_cross_reference: RO:0002211
shorthand: regulates

negatively regulates
type: ObjectProperty
sub property of: regulates
sub property of: causally upstream of, negative effect
inverse of: negatively regulated by
property chain axiom: ends with
IAO_0000115: Process(P1) negatively regulates process(P2) iff: P1 terminates P2, or P1 descreases the the frequency of initiation of P2 or the magnitude or rate of output of P2.
database_cross_reference: RO:0002212
shorthand: negatively_regulates

positively regulates
type: ObjectProperty
sub property of: regulates
sub property of: causally upstream of, positive effect
inverse of: positively regulated by
type: TransitiveProperty
property chain axiom: negatively regulates
property chain axiom: ends with
IAO_0000115: Process(P1) postively regulates process(P2) iff: P1 initiates P2, or P1 increases the the frequency of initiation of P2 or the magnitude or rate of output of P2.
database_cross_reference: RO:0002213
shorthand: positively_regulates

capable of
type: ObjectProperty
sub property of: capable of part of
sub property of: functionally related to
domain: BFO_0000004
range: BFO_0000015
IAO_0000115: A relation between a material entity (such as a cell) and a process, in which the material entity has the ability to carry out the process.
database_cross_reference: RO:0002215
has OBO namespace: uberon
id: capable_of
shorthand: capable_of

capable of part of
type: ObjectProperty
sub property of: functionally related to
sub property of: causal agent in
property chain axiom: capable of
property chain axiom: part_of
IAO_0000115: c stands in this relationship to p if and only if there exists some p' such that c is capable_of p', and p' is part_of p.
database_cross_reference: RO:0002216
has OBO namespace: uberon
id: capable_of_part_of
shorthand: capable_of_part_of

Axiom
annotated source: capable of part of
annotated property: propertyChainAxiom
annotated target: capable of
annotated target: part_of
RO_0002582: true

surrounded_by
type: ObjectProperty
sub property of: adjacent_to
inverse of: surrounds
IAO_0000115: x surrounded_by y if and only if (1) x is adjacent to y and for every region r that is adjacent to x, r overlaps y (2) the shared boundary between x and y occupies the majority of the outermost boundary of x
IAO_0000115: x surrounded_by y iff: x is adjacent to y and for every region r adjacent to x, r overlaps y
database_cross_reference: RO:0002219
has OBO namespace: uberon
id: surrounded_by
shorthand: surrounded_by
label: surrounded by

Axiom
annotated source: surrounded_by
annotated property: IAO_0000115
annotated target: x surrounded_by y iff: x is adjacent to y and for every region r adjacent to x, r overlaps y
database_cross_reference: https://orcid.org/0000-0002-6601-2165

adjacent_to
type: ObjectProperty
type: SymmetricProperty
domain: BFO_0000004
range: BFO_0000004
IAO_0000115: x adjacent to y if and only if x and y share a boundary.
IAO_0000115: x adjacent_to y iff: x and y share a boundary
database_cross_reference: RO:0002220
has OBO namespace: uberon
id: adjacent_to
shorthand: adjacent_to
label: adjacent to

surrounds
type: ObjectProperty
sub property of: adjacent_to
IAO_0000115: inverse of surrounded by
IAO_0000115: inverse of surrounded_by
database_cross_reference: RO:0002221
has OBO namespace: uberon
id: surrounds
shorthand: surrounds

Axiom
annotated source: surrounds
annotated property: IAO_0000115
annotated target: inverse of surrounded_by
database_cross_reference: https://orcid.org/0000-0002-6601-2165

temporally related to
type: ObjectProperty
domain: BFO_0000003
range: BFO_0000003

starts
type: ObjectProperty
sub property of: part_of
sub property of: temporally related to
inverse of: starts with
IAO_0000115: Relation between occurrents, shares a start boundary with.
IAO_0000115: inverse of starts with
database_cross_reference: RO:0002223
has OBO namespace: uberon
id: starts
shorthand: starts

Axiom
annotated source: starts
annotated property: IAO_0000115
annotated target: Relation between occurrents, shares a start boundary with.
database_cross_reference: https://orcid.org/0000-0002-6601-2165
database_cross_reference: Allen:starts

starts with
type: ObjectProperty
sub property of: has_part
sub property of: temporally related to
type: TransitiveProperty
IAO_0000115: x starts with y if and only if x has part y and the time point at which x starts is equivalent to the time point at which y starts. Formally: α(y) = α(x) ∧ ω(y) < ω(x), where α is a function that maps a process to a start point, and ω is a function that maps a process to an end point.
database_cross_reference: RO:0002224
has OBO namespace: uberon
id: starts_with
shorthand: starts_with

develops_from_part_of
type: ObjectProperty
sub property of: develops_from
property chain axiom: directly_develops_from
property chain axiom: part_of
IAO_0000115: x develops from part of y if and only if there exists some z such that x develops from z and z is part of y
database_cross_reference: RO:0002225
has OBO namespace: uberon
id: develops_from_part_of
shorthand: develops_from_part_of
label: develops from part of

develops_in
type: ObjectProperty
sub property of: developmentally preceded by
domain: CARO_0000003
property chain axiom: directly_develops_from
property chain axiom: located_in
IAO_0000115: x develops_in y if x is located in y whilst x is developing
database_cross_reference: RO:0002226
has OBO namespace: uberon
id: develops_in
shorthand: develops_in
comment: This relation take from EHDAA2 - precise semantics yet to be defined
label: develops in

ends
type: ObjectProperty
sub property of: part_of
sub property of: temporally related to
inverse of: ends with
IAO_0000115: Relation between occurrents, shares an end boundary with.
IAO_0000115: inverse of ends with
database_cross_reference: RO:0002229
has exact synonym: finishes
has OBO namespace: uberon
id: ends
shorthand: ends

Axiom
annotated source: ends
annotated property: IAO_0000115
annotated target: Relation between occurrents, shares an end boundary with.
database_cross_reference: https://orcid.org/0000-0002-6601-2165
database_cross_reference: Allen:starts
database_cross_reference: ZFS:finishes

ends with
type: ObjectProperty
sub property of: has_part
sub property of: temporally related to
type: TransitiveProperty
IAO_0000115: x ends with y if and only if x has part y and the time point at which x ends is equivalent to the time point at which y ends. Formally: α(y) > α(x) ∧ ω(y) = ω(x), where α is a function that maps a process to a start point, and ω is a function that maps a process to an end point.
database_cross_reference: RO:0002230
has OBO namespace: uberon
id: ends_with
shorthand: ends_with

has start location
type: ObjectProperty
sub property of: has part that occurs in
domain: BFO_0000015
range: BFO_0000004
property chain axiom: starts with
property chain axiom: occurs in
IAO_0000115: x 'has starts location' y if and only if there exists some process z such that x 'starts with' z and z 'occurs in' y

has end location
type: ObjectProperty
sub property of: has part that occurs in
domain: BFO_0000015
range: BFO_0000004
property chain axiom: ends with
property chain axiom: occurs in
IAO_0000115: x 'has end location' y if and only if there exists some process z such that x 'ends with' z and z 'occurs in' y

has input
type: ObjectProperty
sub property of: has participant
inverse of: input of
property chain axiom: starts with
IAO_0000115: p has direct input c iff c is a participant in p, c is present at the start of p, and the state of c is modified during p.

has output
type: ObjectProperty
sub property of: has participant
inverse of: output of
property chain axiom: ends with
IAO_0000115: p has output c iff c is a participant in p, c is present at the end of p, and c is not present at the beginning of p.

has developmental contribution from
type: ObjectProperty
sub property of: developmentally preceded by
inverse of: developmentally_contributes_to
type: TransitiveProperty
domain: BFO_0000004
range: CARO_0000003
property chain axiom: has_part
property chain axiom: develops_from
IAO_0000115: x has developmental contribution from y iff x has some part z such that z develops from y
database_cross_reference: RO:0002254
has OBO namespace: uberon
id: has_developmental_contribution_from
shorthand: has_developmental_contribution_from

developmentally_contributes_to
type: ObjectProperty
sub property of: developmentally succeeded by
sub property of: has potential to developmentally contribute to
property chain axiom: develops_into
property chain axiom: part_of
IAO_0000115: inverse of has developmental contribution from
database_cross_reference: RO:0002255
has OBO namespace: uberon
id: developmentally_contributes_to
shorthand: developmentally_contributes_to
label: developmentally contributes to

developmentally_induced_by
type: ObjectProperty
sub property of: developmentally preceded by
inverse of: developmentally induces
domain: CARO_0000003
range: CARO_0000003
IAO_0000115: t1 developmentally_induced_by t2 if there is a process of organ induction (GO:0001759) with t1 and t2 as interacting participants. t2 causes t1 to change its fate from a precursor tissue type T to T', where T' develops_from T.
IAO_0000115: t1 induced_by t2 if there is a process of developmental induction (GO:0031128) with t1 and t2 as interacting participants. t2 causes t1 to change its fate from a precursor anatomical structure type T to T', where T' develops_from T
database_cross_reference: RO:0002256
has OBO namespace: uberon
id: developmentally_induced_by
shorthand: developmentally_induced_by
comment: sources for developmentally_induced_by relationships in Uberon: Developmental Biology, Gilbert, 8th edition, figure 6.5(F)
label: developmentally induced by

Axiom
annotated source: developmentally_induced_by
annotated property: IAO_0000115
annotated target: t1 developmentally_induced_by t2 if there is a process of organ induction (GO:0001759) with t1 and t2 as interacting participants. t2 causes t1 to change its fate from a precursor tissue type T to T', where T' develops_from T.
database_cross_reference: GO:0001759

developmentally induces
type: ObjectProperty
sub property of: developmentally succeeded by
IAO_0000115: Inverse of developmentally induced by

developmentally preceded by
type: ObjectProperty
inverse of: developmentally succeeded by
domain: BFO_0000002
range: BFO_0000002
IAO_0000115: Candidate definition: x developmentally related to y if and only if there exists some developmental process (GO:0032502) p such that x and y both participates in p, and x is the output of p and y is the input of p
database_cross_reference: RO:0002258
has OBO namespace: uberon
id: developmentally_preceded_by
shorthand: developmentally_preceded_by

acts upstream of
type: ObjectProperty
sub property of: acts upstream of or within
property chain axiom: enables
property chain axiom: causally upstream of
IAO_0000115: c involved in regulation of p if c enables 'p' and p' causally upstream of p

acts upstream of or within
type: ObjectProperty
sub property of: causal agent in
property chain axiom: enables
property chain axiom: causally upstream of or within
IAO_0000115: c acts upstream of or within p if c is enables 'p' and p' causally upstream of or within p

developmentally_replaces
type: ObjectProperty
sub property of: developmentally preceded by
IAO_0000115: x developmentally replaces y if and only if there is some developmental process that causes x to move or to cease to exist, and for the site that was occupied by x to become occupied by y, where y either comes into existence in this site or moves to this site from somewhere else
database_cross_reference: RO:0002285
has OBO namespace: uberon
id: developmentally_replaces
shorthand: developmentally_replaces
label: developmentally replaces

developmentally succeeded by
type: ObjectProperty
IAO_0000115: Inverse of developmentally preceded by

part of developmental precursor of
type: ObjectProperty
sub property of: developmentally succeeded by
property chain axiom: part_of
property chain axiom: directly develops into

causally upstream of, positive effect
type: ObjectProperty
sub property of: causally upstream of

causally upstream of, negative effect
type: ObjectProperty
sub property of: causally upstream of

confers_advantage_in
type: ObjectProperty
database_cross_reference: RO:0002322
has narrow synonym: adapted_for
has OBO namespace: uberon
id: confers_advantage_in
shorthand: confers_advantage_in
label: confers advantage in

contributes to
type: ObjectProperty
sub property of: capable of part of
sub property of: part of structure that is capable of

enables
type: ObjectProperty
sub property of: capable of
inverse of: enabled by

functionally related to
type: ObjectProperty
database_cross_reference: RO:0002328
has OBO namespace: uberon
id: functionally_related_to
shorthand: functionally_related_to

part of structure that is capable of
type: ObjectProperty
sub property of: functionally related to
property chain axiom: part_of
property chain axiom: capable of
IAO_0000115: this relation holds between c and p when c is part of some c', and c' is capable of p.
database_cross_reference: RO:0002329
has OBO namespace: uberon
id: part_of_structure_that_is_capable_of
shorthand: part_of_structure_that_is_capable_of

Axiom
annotated source: part of structure that is capable of
annotated property: propertyChainAxiom
annotated target: part_of
annotated target: capable of
is a defining property chain axiom: true

involved in
type: ObjectProperty
sub property of: involved in or involved in regulation of
property chain axiom: enables
property chain axiom: part_of
IAO_0000115: c involved_in p if and only if c enables some process p', and p' is part of p

enabled by
type: ObjectProperty
sub property of: functionally related to
sub property of:
  inverse of: capable of
IAO_0000115: inverse of enables

regulated by
type: ObjectProperty
sub property of: causally downstream of or within
type: TransitiveProperty
domain: BFO_0000015
range: BFO_0000015
IAO_0000115: inverse of regulates

negatively regulated by
type: ObjectProperty
sub property of: regulated by
IAO_0000115: inverse of negatively regulates

positively regulated by
type: ObjectProperty
sub property of: regulated by
IAO_0000115: inverse of positively regulates

member of
type: ObjectProperty
sub property of: part_of
inverse of: has member
IAO_0000115: is member of is a mereological relation between a item and a collection.
database_cross_reference: RO:0002350
has OBO namespace: uberon
id: member_of
shorthand: member_of

has member
type: ObjectProperty
sub property of: has_part
type: IrreflexiveProperty
IAO_0000115: has member is a mereological relation between a collection and an item.
database_cross_reference: RO:0002351
has OBO namespace: uberon
id: has_member
shorthand: has_member

input of
type: ObjectProperty
sub property of: participates in
sub property of: functionally related to
IAO_0000115: inverse of has input
database_cross_reference: RO:0002352
has OBO namespace: uberon
id: input_of
shorthand: input_of

output of
type: ObjectProperty
sub property of: participates in
sub property of: functionally related to
IAO_0000115: inverse of has output
database_cross_reference: RO:0002353
has OBO namespace: uberon
id: output_of
shorthand: output_of

attaches_to
type: ObjectProperty
sub property of: connected to
sub property of: connects
sub property of: attaches_to_part_of
type: SymmetricProperty
IAO_0000115: a is attached to b if and only if a and b are discrete objects or object parts, and there are physical connections between a and b such that a force pulling a will move b, or a force pulling b will move a
database_cross_reference: RO:0002371
has OBO namespace: uberon
id: attaches_to
shorthand: attaches_to
label: attached to

has_muscle_origin
type: ObjectProperty
sub property of: attaches_to
sub property of: biomechanically related to
IAO_0000115: m has_muscle_origin s iff m is attached_to s, and it is the case that when m contracts, s does not move. The site of the origin tends to be more proximal and have greater mass than what the other end attaches to.
IAO_0000115: m has_muscle_origin s iff m is attaches_to s, and it is the case that when m contracts, s does not move. The site of the origin tends to be more proximal and have greater mass than what the other end attaches to.
database_cross_reference: RO:0002372
has OBO namespace: uberon
id: has_muscle_origin
shorthand: has_muscle_origin
comment: The origin is the end of a muscle that attaches to the more fixed part of the skeleton, which is the proximal end in limb muscles
label: has muscle origin

Axiom
annotated source: has_muscle_origin
annotated property: IAO_0000115
annotated target: m has_muscle_origin s iff m is attaches_to s, and it is the case that when m contracts, s does not move. The site of the origin tends to be more proximal and have greater mass than what the other end attaches to.
database_cross_reference: Muscles

has_muscle_insertion
type: ObjectProperty
sub property of: attaches_to
sub property of: biomechanically related to
IAO_0000115: m has_muscle_insertion s iff m is attaches_to s, and it is the case that when m contracts, s moves. Insertions are usually connections of muscle via tendon to bone.
database_cross_reference: RO:0002373
has OBO namespace: uberon
id: has_muscle_insertion
shorthand: has_muscle_insertion
comment: The insertion is the point of attachment of a muscle that moves the most when the muscle shortens, or the most distal end of limb muscles
label: has muscle insertion

Axiom
annotated source: has_muscle_insertion
annotated property: IAO_0000115
annotated target: m has_muscle_insertion s iff m is attaches_to s, and it is the case that when m contracts, s moves. Insertions are usually connections of muscle via tendon to bone.
database_cross_reference: Insertion (anatomy)

in branching relationship with
type: ObjectProperty
sub property of: part_of
domain: material entity
range: material entity
IAO_0000115: A relationship that holds between two material entities in a system of connected structures, where the branching relationship holds based on properties of the connecting network.

tributary_of
type: ObjectProperty
sub property of: in branching relationship with
IAO_0000115: x tributary_of y if and only if x a channel for the flow of a substance into y, where y is larger than x. If x and y are hydrographic features, then y is the main stem of a river, or a lake or bay, but not the sea or ocean. If x and y are anatomical, then y is a vein.
database_cross_reference: RO:0002376
has OBO namespace: uberon
has related synonym: drains into
id: tributary_of
shorthand: tributary_of
label: tributary of

Axiom
annotated source: tributary_of
annotated property: hasRelatedSynonym
annotated target: drains into
database_cross_reference: dbpowl:drainsTo

branching_part_of
type: ObjectProperty
sub property of: part_of
sub property of: in branching relationship with
inverse of: has branching part
range: Restriction
  on property: bearer of
  some values from: PATO_0000402
IAO_0000115: x is a branching part of y if and only if x is part of y and x is connected directly or indirectly to the main stem of y
IAO_0000116: we need to check if FMA branch_of implies part_of. the relation we intend to use here should - for example, see vestibulocochlear nerve
database_cross_reference: RO:0002380
has OBO namespace: uberon
id: branching_part_of
shorthand: branching_part_of
label: branching part of

has potential to developmentally contribute to
type: ObjectProperty
IAO_0000115: x has potential to developmentrally contribute to y iff x developmentally contributes to y or x is capable of developmentally contributing to y
database_cross_reference: RO:0002385
has OBO namespace: uberon
id: has_potential_to_developmentally_contribute_to
shorthand: has_potential_to_developmentally_contribute_to

has potential to develop into
type: ObjectProperty
IAO_0000115: x has the potential to develop into y iff x develops into y or if x is capable of developing into y
database_cross_reference: RO:0002387
has OBO namespace: uberon
id: has_potential_to_develop_into
shorthand: has_potential_to_develop_into

has potential to directly develop into
type: ObjectProperty
sub property of: has potential to develop into
IAO_0000115: x has potential to directly develop into y iff x directly develops into y or x is capable of directly developing into y
database_cross_reference: RO:0002388
has OBO namespace: uberon
id: has_potential_to_directly_develop_into
shorthand: has_potential_to_directly_develop_into

causally downstream of
type: ObjectProperty
sub property of: preceded_by
sub property of: causally downstream of or within
inverse of: causally upstream of
IAO_0000115: inverse of upstream of

immediately causally downstream of
type: ObjectProperty
sub property of: immediately_preceded_by
sub property of: causally downstream of
inverse of: immediately causally upstream of

causally upstream of
type: ObjectProperty
sub property of: precedes
sub property of: causally upstream of or within
type: TransitiveProperty
IAO_0000115: p is causally upstream of q if and only if p precedes q and p and q are linked in a causal chain

immediately causally upstream of
type: ObjectProperty
sub property of: immediately precedes
sub property of: causally upstream of
IAO_0000115: p is immediately causally upstream of q iff both (a) p immediately precedes q and (b) p is causally upstream of q. In addition, the output of p must be an input of q.

causally upstream of or within
type: ObjectProperty
sub property of: causal relation between processes
inverse of: causally downstream of or within
type: TransitiveProperty
IAO_0000115: p 'causally upstream or within' q iff (1) the end of p is before the end of q and (2) the execution of p exerts some causal influence over the outputs of q; i.e. if p was abolished or the outputs of p were to be modified, this would necessarily affect q.

causally downstream of or within
type: ObjectProperty
sub property of: causal relation between processes
type: TransitiveProperty
IAO_0000115: inverse of causally upstream of or within

involved in regulation of
type: ObjectProperty
sub property of: acts upstream of
sub property of: involved in or involved in regulation of
property chain axiom: enables
property chain axiom: regulates
property chain axiom: involved in
IAO_0000115: c involved in regulation of p if c is involved in some 'p' and p' regulates some p

involved in positive regulation of
type: ObjectProperty
sub property of: involved in regulation of
property chain axiom: enables
property chain axiom: positively regulates
property chain axiom: involved in

involved in negative regulation of
type: ObjectProperty
sub property of: involved in regulation of
property chain axiom: enables
property chain axiom: negatively regulates
property chain axiom: involved in

involved in or involved in regulation of
type: ObjectProperty
sub property of: acts upstream of or within
sub property of: functionally related to
sub property of: causal agent in
IAO_0000115: c involved in or regulates p if and only if either (i) c is involved in p or (ii) c is involved in regulation of p

enables activity in
type: ObjectProperty
sub property of: functionally related to
property chain axiom: enables
property chain axiom: occurs in
IAO_0000115: c executes activity in d if and only if c enables p and p occurs_in d

Axiom
annotated source: enables activity in
annotated property: propertyChainAxiom
annotated target: enables
annotated target: occurs in
is a defining property chain axiom: true

contributes to morphology of
type: ObjectProperty
IAO_0000115: p contributes to morphology of w if and only if a change in the morphology of p entails a change in the morphology of w. Examples: every skull contributes to morphology of the head which it is a part of. Counter-example: nuclei do not generally contribute to the morphology of the cell they are part of, as they are buffered by cytoplasm.
database_cross_reference: RO:0002433
has OBO namespace: uberon
id: contributes_to_morphology_of
shorthand: contributes_to_morphology_of

interacts with
type: ObjectProperty
type: SymmetricProperty
domain: material entity
range: material entity
IAO_0000115: A relationship that holds between two entities in which the processes executed by the two entities are causally connected.

molecularly interacts with
type: ObjectProperty
sub property of: interacts with
type: SymmetricProperty
IAO_0000115: An interaction relationship in which the two partners are molecular entities and are executing molecular processes that are directly causally connected.

molecularly controls
type: ObjectProperty
sub property of: molecularly interacts with
sub property of: causally influences
property chain axiom: enables
property chain axiom: regulates
property chain axiom: enabled by
IAO_0000115: Holds between molecular entities a and b when the execution of a activates or inhibits the activity of b

composed primarily of
type: ObjectProperty
sub property of: has_part
IAO_0000115: x composed_primarily_of y if and only if more than half of the mass of x is made from y or units of the same type as y.
IAO_0000115: x composed_primarily_of y iff: more than half of the mass of x is made from parts of y
database_cross_reference: RO:0002473
has OBO namespace: uberon
id: composed_primarily_of
shorthand: composed_primarily_of

has part that occurs in
type: ObjectProperty
domain: BFO_0000003
range: BFO_0000004
property chain axiom: has_part
property chain axiom: occurs in
IAO_0000115: p has part that occurs in c if and only if there exists some p1, such that p has_part p1, and p1 occurs in c.

Axiom
annotated source: has part that occurs in
annotated property: propertyChainAxiom
annotated target: has_part
annotated target: occurs in
is a defining property chain axiom: true

relation between structure and stage
type: ObjectProperty
domain: BFO_0000002
range: BFO_0000003

existence starts during
type: ObjectProperty
sub property of: existence overlaps
sub property of: existence starts during or after
property chain axiom: part_of
IAO_0000115: Relation between continuant c and occurrent s, such that every instance of c comes into existing during some s.
IAO_0000115: x existence starts during y if and only if the time point at which x starts is after or equivalent to the time point at which y starts and before or equivalent to the time point at which y ends. Formally: x existence starts during y iff α(x) >= α(y) & α(x) <= ω(y).
database_cross_reference: RO:0002488
has exact synonym: begins_to_exist_during
has OBO namespace: uberon
id: existence_starts_during
shorthand: existence_starts_during

Axiom
annotated source: existence starts during
annotated property: IAO_0000115
annotated target: Relation between continuant c and occurrent s, such that every instance of c comes into existing during some s.
database_cross_reference: https://orcid.org/0000-0002-6601-2165

existence starts with
type: ObjectProperty
sub property of: existence starts during
IAO_0000115: Relation between continuant and occurrent, such that c comes into existence at the start of p.
IAO_0000115: x starts ends with y if and only if the time point at which x starts is equivalent to the time point at which y starts. Formally: x existence starts with y iff α(x) = α(y).
database_cross_reference: RO:0002489
has OBO namespace: uberon
id: existence_starts_with
shorthand: existence_starts_with

Axiom
annotated source: existence starts with
annotated property: IAO_0000115
annotated target: Relation between continuant and occurrent, such that c comes into existence at the start of p.
database_cross_reference: https://orcid.org/0000-0002-6601-2165

existence overlaps
type: ObjectProperty
sub property of: relation between structure and stage
IAO_0000115: x existence overlaps y if and only if either (a) the start of x is part of y or (b) the end of x is part of y. Formally: x existence starts and ends during y iff (α(x) >= α(y) & α(x) <= ω(y)) OR (ω(x) <= ω(y) & ω(x) >= α(y))

existence ends during
type: ObjectProperty
sub property of: existence overlaps
sub property of: existence ends during or before
property chain axiom: part_of
IAO_0000115: Relation between continuant c and occurrent s, such that every instance of c ceases to exist during some s, if it does not die prematurely.
IAO_0000115: x existence ends during y if and only if the time point at which x ends is before or equivalent to the time point at which y ends and after or equivalent to the point at which y starts. Formally: x existence ends during y iff ω(x) <= ω(y) and ω(x) >= α(y).
database_cross_reference: RO:0002492
has exact synonym: ceases_to_exist_during
has OBO namespace: uberon
id: existence_ends_during
shorthand: existence_ends_during

Axiom
annotated source: existence ends during
annotated property: IAO_0000115
annotated target: Relation between continuant c and occurrent s, such that every instance of c ceases to exist during some s, if it does not die prematurely.
database_cross_reference: https://orcid.org/0000-0002-6601-2165

existence ends with
type: ObjectProperty
sub property of: existence ends during
IAO_0000115: Relation between continuant and occurrent, such that c ceases to exist at the end of p.
IAO_0000115: x existence ends with y if and only if the time point at which x ends is equivalent to the time point at which y ends. Formally: x existence ends with y iff ω(x) = ω(y).
database_cross_reference: RO:0002493
has OBO namespace: uberon
id: existence_ends_with
shorthand: existence_ends_with

Axiom
annotated source: existence ends with
annotated property: IAO_0000115
annotated target: Relation between continuant and occurrent, such that c ceases to exist at the end of p.
database_cross_reference: https://orcid.org/0000-0002-6601-2165

transformation of
type: ObjectProperty
sub property of: develops_from
type: TransitiveProperty
IAO_0000115: x transformation of y if x is the immediate transformation of y, or is linked to y through a chain of transformation relationships
database_cross_reference: RO:0002494
has exact synonym: transforms from
has OBO namespace: uberon
id: transformation_of
shorthand: transformation_of

Axiom
annotated source: transformation of
annotated property: hasExactSynonym
annotated target: transforms from
database_cross_reference: SIO:000657

immediate transformation of
type: ObjectProperty
sub property of: directly_develops_from
sub property of: transformation of
IAO_0000115: x immediate transformation of y iff x immediately succeeds y temporally at a time boundary t, and all of the matter present in x at t is present in y at t, and all the matter in y at t is present in x at t
database_cross_reference: RO:0002495
has exact synonym: direct_transformation_of
has exact synonym: immediately transforms from
has OBO namespace: uberon
id: immediate_transformation_of
shorthand: immediate_transformation_of

Axiom
annotated source: immediate transformation of
annotated property: hasExactSynonym
annotated target: direct_transformation_of
database_cross_reference: https://orcid.org/0000-0002-6601-2165

Axiom
annotated source: immediate transformation of
annotated property: hasExactSynonym
annotated target: immediately transforms from
database_cross_reference: SIO:000658

existence starts during or after
type: ObjectProperty
sub property of: relation between structure and stage
property chain axiom: part_of
property chain axiom: developmentally preceded by
property chain axiom: preceded_by
property chain axiom: simultaneous_with
IAO_0000115: x existence starts during or after y if and only if the time point at which x starts is after or equivalent to the time point at which y starts. Formally: x existence starts during or after y iff α (x) >= α (y).
database_cross_reference: RO:0002496
has OBO namespace: uberon
id: existence_starts_during_or_after
shorthand: existence_starts_during_or_after

existence ends during or before
type: ObjectProperty
sub property of: relation between structure and stage
property chain axiom: part_of
property chain axiom: developmentally succeeded by
property chain axiom: precedes
property chain axiom: simultaneous_with
IAO_0000115: x existence ends during or before y if and only if the time point at which x ends is before or equivalent to the time point at which y ends.
database_cross_reference: RO:0002497
has OBO namespace: uberon
id: existence_ends_during_or_before
shorthand: existence_ends_during_or_before

causal agent in
type: ObjectProperty
sub property of: causal relation between material entity and a process
inverse of: has causal agent
IAO_0000115: A relationship between a material entity and a process where the material entity has some causal role that influences the process

causal relation between processes
type: ObjectProperty
domain: BFO_0000003
range: BFO_0000003
IAO_0000115: p is causally related to q if and only if p or any part of p and q or any part of q are linked by a chain of events where each event pair is one of direct activation or direct inhibition. p may be upstream, downstream, part of or a container of q.

causal relation between material entities
type: ObjectProperty
domain: material entity
range: material entity

has skeleton
type: ObjectProperty
sub property of: has_part
inverse of: skeleton of
IAO_0000115: A relation between a segment or subdivision of an organism and the maximal subdivision of material entities that provides structural support for that segment or subdivision.
IAO_0000115: A relation between a subdivision of an organism and the single subdivision of skeleton that provides structural support for that subdivision.
database_cross_reference: RO:0002551
has OBO namespace: uberon
has related synonym: has sekeletal support
has related synonym: has supporting framework
id: has_skeleton
shorthand: has_skeleton

Axiom
annotated source: has skeleton
annotated property: IAO_0000115
annotated target: A relation between a subdivision of an organism and the single subdivision of skeleton that provides structural support for that subdivision.
database_cross_reference: http://orcid.org/0000-0002-6601-2165

causally influenced by
type: ObjectProperty
sub property of: causal relation between material entities
inverse of: causally influences

causally influences
type: ObjectProperty
sub property of: causal relation between material entities
property chain axiom: enables
property chain axiom: causally upstream of
property chain axiom: has input
property chain axiom: enabled by
IAO_0000115: Holds between materal entities a and b if the activity of a is causally upstream of the activity of b, or causally upstream of a an activity that modifies b

biomechanically related to
type: ObjectProperty
sub property of: functionally related to
IAO_0000115: A relation that holds between elements of a musculoskeletal system or its analogs.

has muscle antagonist
type: ObjectProperty
sub property of: biomechanically related to
IAO_0000115: m1 has_muscle_antagonist m2 iff m1 acts in opposition to m2, and m2 is responsible for returning the structure to its initial position.
IAO_0000115: m1 has_muscle_antagonist m2 iff m1 has_muscle_insertion s, m2 has_muscle_insection s, m1 acts in opposition to m2, and m2 is responsible for returning the structure to its initial position.
database_cross_reference: RO:0002568
has OBO namespace: uberon
id: has_muscle_antagonist
shorthand: has_muscle_antagonist
label: has_muscle_antagonist

Axiom
annotated source: has muscle antagonist
annotated property: IAO_0000115
annotated target: m1 has_muscle_antagonist m2 iff m1 acts in opposition to m2, and m2 is responsible for returning the structure to its initial position.
database_cross_reference: Antagonist (muscle)

has branching part
type: ObjectProperty
sub property of: in branching relationship with
type: TransitiveProperty
IAO_0000115: inverse of branching part of
database_cross_reference: RO:0002569
has OBO namespace: uberon
id: has_branching_part
shorthand: has_branching_part

lumen of
type: ObjectProperty
sub property of: part_of
range: material entity
IAO_0000115: x lumen_of y iff x is the space or substance that is part of y and does not cross any of the inner membranes or boundaries of y that is maximal with respect to the volume of the convex hull.
database_cross_reference: RO:0002571
has OBO namespace: uberon
id: lumen_of
shorthand: lumen_of

luminal space of
type: ObjectProperty
sub property of: part_of
sub property of: lumen of
domain: BFO_0000141
IAO_0000115: s is luminal space of x iff s is lumen_of x and s is an immaterial entity
database_cross_reference: RO:0002572
has OBO namespace: uberon
id: luminal_space_of
shorthand: luminal_space_of

skeleton of
type: ObjectProperty
sub property of: part_of
domain: CARO_0000003
range: CARO_0000003
IAO_0000115: inverse of has skeleton
database_cross_reference: RO:0002576
has OBO namespace: uberon
id: skeleton_of
shorthand: skeleton_of

directly regulates
type: ObjectProperty
sub property of: regulates
sub property of: immediately causally upstream of
IAO_0000115: Process(P1) directly regulates process(P2) iff: P1 regulates P2 via direct physical interaction between an agent executing P1 (or some part of P1) and an agent executing P2 (or some part of P2). For example, if protein A has protein binding activity(P1) that targets protein B and this binding regulates the kinase activity (P2) of protein B then P1 directly regulates P2.

has part structure that is capable of
type: ObjectProperty
sub property of: functionally related to
sub property of: causal relation between material entity and a process
property chain axiom: has_part
property chain axiom: capable of
IAO_0000115: s 'has part structure that is capable of' p if and only if there exists some part x such that s 'has part' x and x 'capable of' p

causal relation between material entity and a process
type: ObjectProperty
domain: material entity
range: BFO_0000015
IAO_0000115: A relationship that holds between a material entity and a process in which causality is involved, with either the material entity or some part of the material entity exerting some influence over the process, or the process influencing some aspect of the material entity.

capable of regulating
type: ObjectProperty
sub property of: causal agent in
property chain axiom: capable of
property chain axiom: regulates
IAO_0000115: Holds between c and p if and only if c is capable of some activity a, and a regulates p.

capable of negatively regulating
type: ObjectProperty
sub property of: capable of regulating
property chain axiom: capable of
property chain axiom: negatively regulates
IAO_0000115: Holds between c and p if and only if c is capable of some activity a, and a negatively regulates p.

capable of positively regulating
type: ObjectProperty
sub property of: capable of regulating
property chain axiom: capable of
property chain axiom: positively regulates
IAO_0000115: Holds between c and p if and only if c is capable of some activity a, and a positively regulates p.

has causal agent
type: ObjectProperty
IAO_0000115: Inverse of 'causal agent in'

produces
type: ObjectProperty
inverse of: produced_by
domain: material entity
range: material entity
property chain axiom:
  inverse of: occurs in
property chain axiom: has output
IAO_0000115: a produces b if some process that occurs_in a has_output b, where a and b are material entities. Examples: hybridoma cell line produces monoclonal antibody reagent; chondroblast produces avascular GAG-rich matrix.
database_cross_reference: RO:0003000
has OBO namespace: uberon
id: produces
shorthand: produces

produced_by
type: ObjectProperty
domain: material entity
range: material entity
IAO_0000115: a produced_by b iff some process that occurs_in b has_output a.
database_cross_reference: RO:0003001
has OBO namespace: uberon
id: produced_by
shorthand: produced_by
label: produced by

anteriorly connected to
type: ObjectProperty
sub property of: posterior_to
sub property of: connected to
sub property of: transitively anteriorly connected to
IAO_0000115: x anteriorly_connected_to y iff the anterior part of x is connected to y. i.e. x connected_to y and x posterior_to y.
has OBO namespace: uberon
id: anteriorly_connected_to

Axiom
annotated source: anteriorly connected to
annotated property: IAO_0000115
annotated target: x anteriorly_connected_to y iff the anterior part of x is connected to y. i.e. x connected_to y and x posterior_to y.
database_cross_reference: Connectivity-Design-Pattern

channel for
type: ObjectProperty
has broad synonym: carries
has OBO namespace: uberon
id: channel_for

channels_from
type: ObjectProperty
type: TransitiveProperty
has OBO namespace: uberon
id: channels_from

channels_into
type: ObjectProperty
type: TransitiveProperty
has OBO namespace: uberon
id: channels_into

conduit for
type: ObjectProperty
IAO_0000115: x is a conduit for y iff y passes through the lumen of x.
has OBO namespace: uberon
id: conduit_for

distally connected to
type: ObjectProperty
sub property of: proximal_to
sub property of: connected to
sub property of: transitively distally connected to
inverse of: proximally connected to
IAO_0000115: x distally_connected_to y iff the distal part of x is connected to y. i.e. x connected_to y and x proximal_to y.
has OBO namespace: uberon
id: distally_connected_to

Axiom
annotated source: distally connected to
annotated property: IAO_0000115
annotated target: x distally_connected_to y iff the distal part of x is connected to y. i.e. x connected_to y and x proximal_to y.
database_cross_reference: Connectivity-Design-Pattern

existence starts and ends during
type: ObjectProperty
sub property of: existence starts during
sub property of: existence ends during
has OBO namespace: uberon
id: existence_starts_and_ends_during

extends_fibers_into
type: ObjectProperty
sub property of: connected to
type: SymmetricProperty
has OBO namespace: uberon
id: extends_fibers_into

filtered through
type: ObjectProperty
IAO_0000115: Relationship between a fluid and a material entity, where the fluid is the output of a realization of a filtration role that inheres in the material entity.
has OBO namespace: uberon
id: filtered_through
comment: Relationship between a fluid and a filtration barrier, where the portion of fluid arises as a transformation of another portion of fluid on the other side of the barrier, with larger particles removed

indirectly_supplies
type: ObjectProperty
type: TransitiveProperty
property chain axiom: has branching part
property chain axiom: supplies
IAO_0000115: a indirectly_supplies s iff a has a branch and the branch supplies or indirectly supplies s
IAO_0000116: add to RO
has OBO namespace: uberon
id: indirectly_supplies

posteriorly connected to
type: ObjectProperty
sub property of: anterior_to
sub property of: connected to
IAO_0000115: x posteriorly_connected_to y iff the posterior part of x is connected to y. i.e. x connected_to y and x anterior_to y.
has OBO namespace: uberon
id: posteriorly_connected_to

Axiom
annotated source: posteriorly connected to
annotated property: IAO_0000115
annotated target: x posteriorly_connected_to y iff the posterior part of x is connected to y. i.e. x connected_to y and x anterior_to y.
database_cross_reference: Connectivity-Design-Pattern

protects
type: ObjectProperty
has OBO namespace: uberon
id: protects

proximally connected to
type: ObjectProperty
sub property of: distal_to
sub property of: connected to
sub property of: transitively proximally connected to
IAO_0000115: x proximally_connected_to y iff the proximal part of x is connected to y. i.e. x connected_to y and x distal_to y.
has OBO namespace: uberon
id: proximally_connected_to

Axiom
annotated source: proximally connected to
annotated property: IAO_0000115
annotated target: x proximally_connected_to y iff the proximal part of x is connected to y. i.e. x connected_to y and x distal_to y.
database_cross_reference: Connectivity-Design-Pattern

sexually_homologous_to
type: ObjectProperty
sub property of: homologous_to
has OBO namespace: uberon
id: sexually_homologous_to

site_of
type: ObjectProperty
IAO_0000115: c site_of p if c is the bearer of a disposition that is realized by a process that has p as part
has OBO namespace: uberon
has related synonym: capable_of_has_part
id: site_of

subdivision of
type: ObjectProperty
has OBO namespace: uberon
id: subdivision_of
comment: placeholder relation. X = 'subdivision of A' and subdivision_of some B means that X is the mereological sum of A and B

transitively anteriorly connected to
type: ObjectProperty
type: TransitiveProperty
IAO_0000115: .
has OBO namespace: uberon
id: transitively_anteriorly_connected_to

Axiom
annotated source: transitively anteriorly connected to
annotated property: IAO_0000115
annotated target: .
database_cross_reference: Connectivity-Design-Pattern

transitively_connected to
type: ObjectProperty
type: TransitiveProperty
has OBO namespace: uberon
id: transitively_connected_to

transitively distally connected to
type: ObjectProperty
type: TransitiveProperty
IAO_0000115: .
has OBO namespace: uberon
id: transitively_distally_connected_to

Axiom
annotated source: transitively distally connected to
annotated property: IAO_0000115
annotated target: .
database_cross_reference: Connectivity-Design-Pattern

transitively proximally connected to
type: ObjectProperty
type: TransitiveProperty
IAO_0000115: .
has OBO namespace: uberon
id: transitively_proximally_connected_to

Axiom
annotated source: transitively proximally connected to
annotated property: IAO_0000115
annotated target: .
database_cross_reference: Connectivity-Design-Pattern

object
type: Class
subclass of: material entity

material entity
type: Class
subclass of: BFO_0000004

electron
type: Class
subclass of: lepton

dicarboxylic acids and O-substituted derivatives
type: Class
subclass of: carbonyl compound

apoprotein
type: Class
subclass of: simple protein

squalene
type: Class
subclass of: triterpene

polypeptide
type: Class
subclass of: peptide
subclass of: macromolecule

hyaluronic acid
type: Class
subclass of: mucopolysaccharide
subclass of: exopolysaccharide

protein polypeptide chain
type: Class
subclass of: polypeptide
subclass of: Restriction
  on property: has_part
  some values from: proteinogenic amino-acid residue

peptide
type: Class
subclass of: carboxamide
subclass of: organic amino compound
subclass of: Restriction
  on property: has_part
  some values from: amino-acid residue

bilirubin
type: Class
subclass of: dicarboxylic acid
subclass of: biladienes

glycoprotein
type: Class
subclass of: conjugated protein
subclass of: carbohydrate derivative

lipid
type: Class
subclass of: organic molecular entity

glycosaminoglycan
type: Class
subclass of: aminoglycan

acyl group
type: Class
subclass of: organic group

alkali metal atom
type: Class
subclass of: main group element atom
subclass of: metal atom
subclass of: s-block element atom

aminoglycan
type: Class
subclass of: organonitrogen compound
subclass of: polysaccharide derivative

anion
type: Class
subclass of: ion

bile salt
type: Class
subclass of: cholanoid
subclass of: organic sodium salt

carbamoyl group
type: Class
subclass of: univalent carboacyl group

carbonyl group
type: Class
subclass of: organodiyl group

molecular entity
type: Class
subclass of: object
subclass of: chemical entity

monoatomic cation
type: Class
subclass of: monoatomic ion
subclass of: cation

chemical entity
type: Class

group
type: Class
subclass of: chemical entity
subclass of: Restriction
  on property: has_part
  some values from: atom

organic heterocyclic compound
type: Class
subclass of: heteroorganic entity
subclass of: organic cyclic compound
subclass of: heterocyclic compound

hydrocarbon
type: Class
subclass of: organic fundamental parent

hydroxides
type: Class
subclass of: oxygen molecular entity
subclass of: hydrogen molecular entity
subclass of: heteroatomic molecular entity
subclass of: Restriction
  on property: has_part
  some values from: hydroxy group

oxoacid
type: Class
subclass of: hydroxides

inorganic molecular entity
type: Class
subclass of: molecular entity

salt
type: Class
subclass of: heteroatomic molecular entity
subclass of: Restriction
  on property: has_part
  some values from: anion
subclass of: Restriction
  on property: has_part
  some values from: cation

monoatomic ion
type: Class
subclass of: ion
subclass of: monoatomic entity

organic salt
type: Class
subclass of: salt

ion
type: Class
subclass of: molecular entity

isoprenoid
type: Class
subclass of: lipid

linear tetrapyrrole
type: Class
subclass of: tetrapyrrole

metal cation
type: Class
subclass of: monoatomic cation
subclass of: inorganic cation

molecule
type: Class
subclass of: polyatomic entity

monoatomic monocation
type: Class
subclass of: monoatomic cation

nitrogen atom
type: Class
subclass of: nonmetal atom
subclass of: pnictogen

nonmetal atom
type: Class
subclass of: atom

organic sulfate
type: Class
subclass of: sulfates
subclass of: organosulfur compound

oxygen atom
type: Class
subclass of: nonmetal atom
subclass of: chalcogen

oxygen molecular entity
type: Class
subclass of: chalcogen molecular entity
subclass of: Restriction
  on property: has_part
  some values from: oxygen atom

sodium atom
type: Class
subclass of: alkali metal atom

sodium molecular entity
type: Class
subclass of: alkali metal molecular entity
subclass of: Restriction
  on property: has_part
  some values from: sodium atom

sodium salt
type: Class
subclass of: sodium molecular entity
subclass of: alkali metal salt
subclass of: Restriction
  on property: has_part
  some values from: sodium(1+)

sulfuric ester
type: Class
subclass of: ester
subclass of: sulfuric acid derivative

sulfates
type: Class
subclass of: sulfuric acid derivative

sulfur atom
type: Class
subclass of: nonmetal atom
subclass of: chalcogen

sulfur molecular entity
type: Class
subclass of: chalcogen molecular entity
subclass of: Restriction
  on property: has_part
  some values from: sulfur atom

tetrapyrrole
type: Class
subclass of: heteroarene
subclass of: polypyrrole

univalent carboacyl group
type: Class
subclass of: carboacyl group

carbon atom
type: Class
subclass of: nonmetal atom
subclass of: carbon group element atom

sodium(1+)
type: Class
subclass of: monoatomic monocation
subclass of: alkali metal cation
subclass of: elemental sodium
subclass of: monovalent inorganic cation

amide
type: Class
subclass of: nitrogen molecular entity

fundamental particle
type: Class
subclass of: subatomic particle

monoatomic entity
type: Class
subclass of: elemental molecular entity

oxoacid derivative
type: Class
subclass of: heteroatomic molecular entity

organic fundamental parent
type: Class
subclass of: organic hydride
subclass of: organic molecular entity

inorganic group
type: Class
subclass of: group

organic group
type: Class
subclass of: group

organyl group
type: Class
subclass of: organic univalent group

atom
type: Class
subclass of: chemical entity
subclass of: Restriction
  on property: has_part
  some values from: electron
subclass of: Restriction
  on property: has_part
  some values from: atomic nucleus

atomic nucleus
type: Class
subclass of: nuclear particle
subclass of: Restriction
  on property: has_part
  some values from: nucleon

nucleon
type: Class
subclass of: baryon
subclass of: nuclear particle

primary amide
type: Class
subclass of: amide

elemental molecular entity
type: Class
subclass of: molecular entity

organosulfur compound
type: Class
subclass of: sulfur molecular entity
subclass of: organochalcogen compound

heteroorganic entity
type: Class
subclass of: organic molecular entity

alkali metal molecular entity
type: Class
subclass of: s-block molecular entity
subclass of: Restriction
  on property: has_part
  some values from: alkali metal atom

pnictogen
type: Class
subclass of: p-block element atom

pnictogen molecular entity
type: Class
subclass of: p-block molecular entity
subclass of: Restriction
  on property: has_part
  some values from: pnictogen

chalcogen
type: Class
subclass of: p-block element atom

chalcogen molecular entity
type: Class
subclass of: p-block molecular entity
subclass of: Restriction
  on property: has_part
  some values from: chalcogen

carbon group element atom
type: Class
subclass of: p-block element atom

main group element atom
type: Class
subclass of: atom

sulfur oxoacid derivative
type: Class
subclass of: sulfur molecular entity
subclass of: oxoacid derivative

alkali metal cation
type: Class
subclass of: metal cation

metal atom
type: Class
subclass of: atom

s-block element atom
type: Class
subclass of: atom

p-block element atom
type: Class
subclass of: main group element atom

carboxylic acid
type: Class
subclass of: carbon oxoacid
subclass of: carbonyl compound
subclass of: organic acid
subclass of: Restriction
  on property: has_part
  some values from: carboxy group

main group molecular entity
type: Class
subclass of: molecular entity
subclass of: Restriction
  on property: has_part
  some values from: main group element atom

carbon group molecular entity
type: Class
subclass of: p-block molecular entity
subclass of: Restriction
  on property: has_part
  some values from: carbon group element atom

cyclic compound
type: Class
subclass of: molecule

hydrogen molecular entity
type: Class
subclass of: s-block molecular entity
subclass of: Restriction
  on property: has_part
  some values from: hydrogen atom

polycyclic compound
type: Class
subclass of: cyclic compound

aromatic compound
type: Class
subclass of: cyclic compound

organic aromatic compound
type: Class
subclass of: aromatic compound
subclass of: organic cyclic compound

s-block molecular entity
type: Class
subclass of: main group molecular entity
subclass of: Restriction
  on property: has_part
  some values from: s-block element atom

p-block molecular entity
type: Class
subclass of: main group molecular entity
subclass of: Restriction
  on property: has_part
  some values from: p-block element atom

hydrides
type: Class
subclass of: hydrogen molecular entity
subclass of: heteroatomic molecular entity

biomacromolecule
type: Class
subclass of: macromolecule
subclass of: organic molecular entity

information biomacromolecule
type: Class
subclass of: biomacromolecule

proteinogenic amino-acid residue
type: Class
subclass of: alpha-amino-acid residue

amino-acid residue
type: Class
subclass of: organic group

alpha-amino-acid residue
type: Class
subclass of: amino-acid residue

organic cyclic compound
type: Class
subclass of: cyclic compound
subclass of: organic molecule

heteroarene
type: Class
subclass of: organic heterocyclic compound
subclass of: organic aromatic compound

conjugated protein
type: Class
subclass of: protein

macromolecule
type: Class
subclass of: polyatomic entity

terpene
type: Class
subclass of: hydrocarbon
subclass of: isoprenoid

triterpene
type: Class
subclass of: terpene

steroid
type: Class
subclass of: lipid
subclass of: organic polycyclic compound

organonitrogen compound
type: Class
subclass of: heteroorganic entity
subclass of: nitrogen molecular entity

alkali metal salt
type: Class
subclass of: salt
subclass of: alkali metal molecular entity

carbon oxoacid
type: Class
subclass of: oxoacid
subclass of: organooxygen compound

dicarboxylic acid
type: Class
subclass of: dicarboxylic acids and O-substituted derivatives
subclass of: carboxylic acid

ester
type: Class
subclass of: organooxygen compound

sulfated glycosaminoglycan
type: Class
subclass of: glycosaminoglycan
subclass of: carbohydrate sulfate

carbohydrate sulfate
type: Class
subclass of: organic sulfate
subclass of: sulfuric ester
subclass of: carbohydrate derivative

cholanoid
type: Class
subclass of: steroid

protein
type: Class
subclass of: information biomacromolecule
subclass of: Restriction
  on property: has_part
  some values from: protein polypeptide chain

bile acid salt
type: Class
subclass of: organic salt
subclass of: cholanoid

lepton
type: Class
subclass of: fundamental particle
subclass of: fermion

baryon
type: Class
subclass of: fermion
subclass of: hadron

fermion
type: Class
subclass of: subatomic particle

subatomic particle
type: Class

composite particle
type: Class
subclass of: subatomic particle

hadron
type: Class
subclass of: composite particle

nuclear particle
type: Class
subclass of: subatomic particle

polyatomic entity
type: Class
subclass of: molecular entity
subclass of: Restriction
  on property: has_part
  some values from: group

carbonyl compound
type: Class
subclass of: organic oxo compound
subclass of: organooxygen compound
subclass of: Restriction
  on property: has_part
  some values from: carbonyl group

organic oxo compound
type: Class
subclass of: organic molecule
subclass of: Restriction
  on property: has_part
  some values from: oxo group

biladienes
type: Class
subclass of: linear tetrapyrrole

inorganic ion
type: Class
subclass of: inorganic molecular entity
subclass of: ion

inorganic cation
type: Class
subclass of: inorganic ion
subclass of: cation

cation
type: Class
subclass of: ion

organochalcogen compound
type: Class
subclass of: heteroorganic entity
subclass of: chalcogen molecular entity

organooxygen compound
type: Class
subclass of: oxygen molecular entity
subclass of: organochalcogen compound

organic hydride
type: Class
subclass of: hydrides

elemental sodium
type: Class
subclass of: sodium molecular entity

mucopolysaccharide
type: Class
subclass of: glycosaminoglycan

heteroatomic molecular entity
type: Class
subclass of: polyatomic entity

carboxamide
type: Class
subclass of: primary amide
subclass of: organonitrogen compound
subclass of: organooxygen compound
subclass of: Restriction
  on property: has_part
  some values from: carbamoyl group

sulfuric acid derivative
type: Class
subclass of: sulfur oxoacid derivative

carboacyl group
type: Class
subclass of: acyl group

polypyrrole
type: Class
subclass of: organonitrogen heterocyclic compound

organonitrogen heterocyclic compound
type: Class
subclass of: organic heterocyclic compound
subclass of: organonitrogen compound

simple protein
type: Class
subclass of: protein

organic sodium salt
type: Class
subclass of: organic salt
subclass of: sodium salt

apolipoprotein
type: Class
subclass of: apoprotein

inclusion compound
type: Class
subclass of: non-covalently-bound molecular entity

clathrate compound
type: Class
subclass of: inclusion compound

hydroxy group
type: Class
subclass of: inorganic group

oxo group
type: Class
subclass of: inorganic group

mineral
type: Class
subclass of: chemical substance

phosphate mineral
type: Class
subclass of: mineral

carboxy group
type: Class
subclass of: organyl group

hydrogen atom
type: Class
subclass of: inorganic molecular entity
subclass of: nonmetal atom
subclass of: s-block element atom

organic amino compound
type: Class
subclass of: organonitrogen compound

organic molecular entity
type: Class
subclass of: carbon group molecular entity
subclass of: Restriction
  on property: has_part
  some values from: carbon atom

non-covalently-bound molecular entity
type: Class
subclass of: polyatomic entity

nitrogen molecular entity
type: Class
subclass of: pnictogen molecular entity
subclass of: Restriction
  on property: has_part
  some values from: nitrogen atom

organodiyl group
type: Class
subclass of: organic divalent group

organic divalent group
type: Class
subclass of: organic group

organic univalent group
type: Class
subclass of: organic group

organic polycyclic compound
type: Class
subclass of: polycyclic compound
subclass of: organic cyclic compound

apatite
type: Class
subclass of: phosphate mineral

hydroxylapatite
type: Class
subclass of: apatite

heterocyclic compound
type: Class
subclass of: cyclic compound

chemical substance
type: Class
subclass of: chemical entity

monovalent inorganic cation
type: Class
subclass of: inorganic cation

carbohydrate derivative
type: Class
subclass of: carbohydrates and carbohydrate derivatives

organic acid
type: Class
subclass of: organic molecular entity

lipoprotein
type: Class
subclass of: conjugated protein
subclass of: clathrate compound
subclass of: Restriction
  on property: has_part
  some values from: apolipoprotein

polysaccharide derivative
type: Class
subclass of: biomacromolecule
subclass of: carbohydrate derivative

organic molecule
type: Class
subclass of: molecule
subclass of: organic molecular entity

exopolysaccharide
type: Class
subclass of: biomacromolecule

carbohydrates and carbohydrate derivatives
type: Class
subclass of: organooxygen compound

cell
type: Class
subclass of: cellular_component
IAO_0000115: A material entity of anatomical origin (part of or deriving from an organism) that has as its parts a maximally connected cell compartment surrounded by a plasma membrane.
database_cross_reference: CALOHA:TS-2035
database_cross_reference: FMA:68646
database_cross_reference: GO:0005623
database_cross_reference: KUPO:0000002
database_cross_reference: VHOG:0001533
database_cross_reference: WBbt:0004017
database_cross_reference: XAO:0003012
has OBO namespace: cell
id: CL:0000000
in subset: upper level
comment: The definition of cell is intended to represent all cells, and thus a cell is defined as a material entity and not an anatomical structure, which implies that it is part of an organism (or the entirety of one).

native cell
type: Class
subclass of: cell
IAO_0000115: A cell that is found in a natural setting, which includes multicellular organism cells 'in vivo' (i.e. part of an organism), and unicellular organisms 'in environment' (i.e. part of a natural environment).
database_cross_reference: CARO:0000013
has narrow synonym: cell in vivo
has OBO namespace: cell
id: CL:0000003
in subset: upper level
comment: To accommodate unicellular organisms better, 'cell in vivo' has been re-labeled 'native cell' to better represent its intended meaning - that is, that it is a cell in the context of a multicellular organism or in a natural environment. 'Native' is intended to contrast with 'in vitro', which refers to cells or other biological entities that have been intentionally placed in a controlled, non-natural setting for the purpose of study or manipulation. (MAH 1.12.12).

fibroblast neural crest derived
type: Class
equivalent class: Class
  intersection of: fibroblast
  intersection of: Restriction
    on property: develops_from
    some values from: migratory neural crest cell
subclass of: fibroblast
subclass of: Restriction
  on property: develops_from
  some values from: migratory cranial neural crest cell
subclass of: Restriction
  on property: develops_from
  some values from: migratory neural crest cell
has OBO namespace: cell
id: CL:0000005

neuronal receptor cell
type: Class
equivalent class: Class
  intersection of: receptor cell
  intersection of: neuron
  intersection of: Restriction
    on property: capable of
    some values from: GO_0050906
subclass of: sensory neuron
subclass of: receptor cell
subclass of: Restriction
  on property: capable of
  some values from: GO_0050906
has exact synonym: neuronal receptor cell (sensu Animalia)
has OBO namespace: cell
id: CL:0000006

early embryonic cell
type: Class
subclass of: embryonic cell
IAO_0000115: A cell found in the embryo before the formation of all the gem layers is complete.
has OBO namespace: cell
id: CL:0000007

migratory cranial neural crest cell
type: Class
subclass of: migratory neural crest cell
has OBO namespace: cell
id: CL:0000008

migratory trunk neural crest cell
type: Class
subclass of: migratory neural crest cell
has OBO namespace: cell
id: CL:0000011

germ line stem cell
type: Class
equivalent class: Class
  intersection of: germ line cell
  intersection of: Restriction
    on property: capable of
    some values from: stem cell division
subclass of: stem cell
subclass of: germ line cell
subclass of: Restriction
  on property: capable of
  some values from: stem cell division
has exact synonym: germline stem cell
has OBO namespace: cell
id: CL:0000014

male germ cell
type: Class
equivalent class: Class
  intersection of: germ cell
  intersection of: Restriction
    on property: capable of
    some values from: spermatogenesis
subclass of: germ cell
subclass of: Restriction
  on property: capable of
  some values from: spermatogenesis
database_cross_reference: FMA:72290
database_cross_reference: MA:0002765
database_cross_reference: VHOG:0001531
database_cross_reference: ncithesaurus:Spermatogenic_Cell
has OBO namespace: cell
id: CL:0000015

spermatocyte
type: Class
equivalent class: Class
  intersection of: male germ cell
  intersection of: Restriction
    on property: capable of
    some values from: GO_0048137
subclass of: male germ cell
subclass of: Restriction
  on property: develops_from
  some values from: spermatogonium
subclass of: Restriction
  on property: capable of
  some values from: GO_0048137
IAO_0000115: A male germ cell that develops from spermatogonia. The euploid primary spermatocytes undergo meiosis and give rise to the haploid secondary spermatocytes which in turn give rise to spermatids.
database_cross_reference: BTO:0001275
database_cross_reference: CALOHA:TS-0951
database_cross_reference: EMAPA:31484
database_cross_reference: FBbt:00004936
database_cross_reference: FMA:84049
database_cross_reference: WBbt:0006799
has OBO namespace: cell
id: CL:0000017

spermatid
type: Class
subclass of: male germ cell
subclass of: haploid cell
subclass of: Restriction
  on property: develops_from
  some values from: secondary spermatocyte
subclass of: Restriction
  on property: capable of
  some values from: GO_0001675
subclass of: Restriction
  on property: capable of
  some values from: GO_0007288
subclass of: Restriction
  on property: capable of
  some values from: GO_0007289
IAO_0000115: A male germ cell that develops from the haploid secondary spermatocytes. Without further division, spermatids undergo structural changes and give rise to spermatozoa.
database_cross_reference: BTO:0001274
database_cross_reference: CALOHA:TS-0950
database_cross_reference: EMAPA:31486
database_cross_reference: FBbt:00004942
database_cross_reference: FMA:72294
database_cross_reference: WBbt:0006800
has exact synonym: nematoblast
has OBO namespace: cell
id: CL:0000018

sperm
type: Class
equivalent class: Class
  intersection of: male gamete
  intersection of: Restriction
    on property: capable of
    some values from: flagellated sperm motility
  intersection of: Restriction
    on property: capable of
    some values from: sperm capacitation
subclass of: ciliated cell
subclass of: motile cell
subclass of: male gamete
subclass of: Restriction
  on property: develops_from
  some values from: spermatid
subclass of: Restriction
  on property: capable of
  some values from: flagellated sperm motility
subclass of: Restriction
  on property: capable of
  some values from: sperm capacitation
IAO_0000115: A mature male germ cell that develops from a spermatid.
database_cross_reference: BTO:0001277
database_cross_reference: BTO:0002046
database_cross_reference: CALOHA:TS-0949
database_cross_reference: FBbt:00004954
database_cross_reference: FMA:67338
database_cross_reference: WBbt:0006798
has exact synonym: sperm cell
has exact synonym: spermatozoid
has exact synonym: spermatozoon
has OBO namespace: cell
id: CL:0000019

spermatogonium
type: Class
subclass of: male germ cell
IAO_0000115: An euploid male germ cell of an early stage of spermatogenesis.
database_cross_reference: BTO:0000958
database_cross_reference: CALOHA:TS-2193
database_cross_reference: EMAPA:31482
database_cross_reference: FBbt:00004935
database_cross_reference: FMA:72291
has OBO namespace: cell
id: CL:0000020

female germ cell
type: Class
equivalent class: Class
  intersection of: germ cell
  intersection of: Restriction
    on property: capable of
    some values from: oogenesis
subclass of: germ cell
subclass of: Restriction
  on property: capable of
  some values from: oogenesis
IAO_0000115: Female germ cell is a germ cell that supports female gamete production.
database_cross_reference: MA:0000388
database_cross_reference: VHOG:0001530
database_cross_reference: ncithesaurus:Egg
has OBO namespace: cell
id: CL:0000021

female germ line stem cell
type: Class
equivalent class: Class
  intersection of: female germ cell
  intersection of: Restriction
    on property: capable of
    some values from: stem cell division
subclass of: germ line stem cell
subclass of: female germ cell
subclass of: Restriction
  on property: capable of
  some values from: stem cell division
has OBO namespace: cell
id: CL:0000022

oocyte
type: Class
subclass of: female germ cell
IAO_0000115: A female germ cell that has entered meiosis.
database_cross_reference: BTO:0000964
database_cross_reference: CALOHA:TS-0711
database_cross_reference: FBbt:00004886
database_cross_reference: FMA:18644
database_cross_reference: WBbt:0006797
has OBO namespace: cell
has related synonym: oogonium
id: CL:0000023

smooth muscle cell neural crest derived
type: Class
equivalent class: Class
  intersection of: smooth muscle cell
  intersection of: Restriction
    on property: develops_from
    some values from: migratory neural crest cell
subclass of: smooth muscle cell
subclass of: Restriction
  on property: develops_from
  some values from: migratory cranial neural crest cell
subclass of: Restriction
  on property: develops_from
  some values from: migratory neural crest cell
has OBO namespace: cell
id: CL:0000027

neuron neural crest derived
type: Class
equivalent class: Class
  intersection of: neuron
  intersection of: Restriction
    on property: develops_from
    some values from: migratory neural crest cell
subclass of: neuron
subclass of: Restriction
  on property: develops_from
  some values from: migratory neural crest cell
subclass of: Restriction
  on property: develops_from
  some values from: neural crest derived neuroblast
has OBO namespace: cell
id: CL:0000029

glioblast
type: Class
subclass of: non-terminally differentiated cell
subclass of: Restriction
  on property: develops_from
  some values from: neurectodermal cell
database_cross_reference: FBbt:00005145
has OBO namespace: cell
id: CL:0000030

neuroblast
type: Class
subclass of: neuronal stem cell
subclass of: non-terminally differentiated cell
IAO_0000115: A cell that will develop into a neuron often after a migration phase.
database_cross_reference: BTO:0000930
database_cross_reference: FBbt:00005146
database_cross_reference: FMA:70563
has OBO namespace: cell
id: CL:0000031

apocrine cell
type: Class
subclass of: secretory cell
IAO_0000115: An apocrine cell is a secretory cell characterized loss of part of the cytoplasm during the process of secretion - secretions are budded off through the plasma membrane producing membrane bound vesicles containing the secreted substance.
has OBO namespace: cell
id: CL:0000033

stem cell
type: Class
equivalent class: Class
  intersection of: native cell
  intersection of: Restriction
    on property: capable of
    some values from: stem cell division
subclass of: precursor cell
subclass of: Restriction
  on property: capable of
  some values from: stem cell division
subclass of: Restriction
  on property: capable of
  some values from: cell differentiation
IAO_0000115: A relatively undifferentiated cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells.
database_cross_reference: CALOHA:TS-2086
database_cross_reference: FMA:63368
has OBO namespace: cell
id: CL:0000034

single fate stem cell
type: Class
subclass of: somatic stem cell
subclass of: Restriction
  on property: capable of
  some values from: stem cell division
IAO_0000115: A stem cell that self-renews as well as give rise to a single mature cell type.
database_cross_reference: FMA:70569
has exact synonym: unipotent stem cell
has exact synonym: unipotential stem cell
has OBO namespace: cell
id: CL:0000035

epithelial fate stem cell
type: Class
subclass of: single fate stem cell
has OBO namespace: cell
id: CL:0000036

hematopoietic stem cell
type: Class
subclass of: somatic stem cell
subclass of: hematopoietic precursor cell
subclass of: Restriction
  on property: develops_from
  some values from: angioblastic mesenchymal cell
subclass of: Restriction
  on property: capable of
  some values from: GO_0002244
subclass of: Restriction
  on property: capable of
  some values from: GO_0048103
IAO_0000115: A stem cell from which all cells of the lymphoid and myeloid lineages develop, including blood cells and cells of the immune system. Hematopoietic stem cells lack cell markers of effector cells (lin-negative). Lin-negative is defined by lacking one or more of the following cell surface markers: CD2, CD3 epsilon, CD4, CD5 ,CD8 alpha chain, CD11b, CD14, CD19, CD20, CD56, ly6G, ter119.
database_cross_reference: BTO:0000725
database_cross_reference: CALOHA:TS-0448
database_cross_reference: FMA:70337
database_cross_reference: FMA:86475
database_cross_reference: VHOG:0001485
has exact synonym: HSC
has exact synonym: blood forming stem cell
has exact synonym: hemopoietic stem cell
has OBO namespace: cell
has related synonym: colony forming unit hematopoietic
id: CL:0000037
comment: Markers differ between species, and two sets of markers have been described for mice. HSCs are reportedly CD34-positive, CD45-positive, CD48-negative, CD150-positive, CD133-positive, and CD244-negative.

erythroid progenitor cell
type: Class
subclass of: erythroid lineage cell
subclass of: myeloid lineage restricted progenitor cell
subclass of: Restriction
  on property: develops_from
  some values from: megakaryocyte-erythroid progenitor cell
IAO_0000115: A progenitor cell committed to the erythroid lineage.
database_cross_reference: BTO:0004911
has OBO namespace: cell
has related synonym: BFU-E
has related synonym: CFU-E
has related synonym: blast forming unit erythroid
has related synonym: burst forming unit erythroid
has related synonym: colony forming unit erythroid
has related synonym: erythroid stem cell
id: CL:0000038

germ line cell
type: Class
subclass of: material entity
subclass of: animal cell
subclass of: Restriction
  on property: capable of
  some values from: reproductive process
disjoint with: somatic cell
IAO_0000115: A cell that is within the developmental lineage of gametes and is able to pass along its genetic material to offspring.
has OBO namespace: cell
id: CL:0000039
in subset: upper level
comment: Originally this term had some plant germ line cell children.

monoblast
type: Class
subclass of: myeloid cell
subclass of: monopoietic cell
subclass of: Restriction
  on property: has_part
  some values from: CP_0000028
subclass of: Restriction
  on property: has_part
  some values from: GO_0000791
subclass of: Restriction
  on property: has_part
  some values from: GO_0005730
subclass of: Restriction
  on property: develops_from
  some values from: macrophage dendritic cell progenitor
subclass of: Restriction
  on property: capable of
  some values from: GO_0030224
IAO_0000115: A myeloid progenitor cell committed to the monocyte lineage. This cell is CD11b-positive, has basophilic cytoplasm, euchromatin, and the presence of a nucleolus.
database_cross_reference: CALOHA:TS-1195
database_cross_reference: FMA:83553
has OBO namespace: cell
has related synonym: CFU-M
has related synonym: colony forming unit macrophage
has related synonym: colony forming unit monocyte
has related synonym: monocyte stem cell
id: CL:0000040
comment: Morphology: mononuclear cell, diameter 12-20 _M, non-granular, N/C ratio 3/1 - 4/1; markers: CD11b (shared with many other myeloid cells); location: Adult: bone marrow; fetal: liver, Yolk Sac; role or process: hematopoiesis, monocyte development; lineage: hematopoietic, myeloid.

neuronal stem cell
type: Class
equivalent class: Class
  intersection of: multi fate stem cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0001017
subclass of: multi fate stem cell
subclass of: neural cell
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0001017
subclass of: Restriction
  on property: develops_from
  some values from: neurectodermal cell
IAO_0000115: Neural stem cell is characterized as an undifferentiated cell that originates from the neuroectoderm and has the capacity both to perpetually self-renew without differentiating and to generate multiple types of lineage-restricted progenitors.
database_cross_reference: BTO:0002881
database_cross_reference: CALOHA:TS-2360
database_cross_reference: FMA:86684
has exact synonym: NSC
has exact synonym: neural stem cell
has OBO namespace: cell
id: CL:0000047

multi fate stem cell
type: Class
subclass of: stem cell
subclass of: somatic cell
subclass of: Restriction
  on property: capable of
  some values from: stem cell division
IAO_0000115: A stem cell that can give rise to multiple lineages of cells.
database_cross_reference: FMA:84789
has exact synonym: multi-fate stem cell
has exact synonym: multifate stem cell
has exact synonym: multipotent cell
has exact synonym: multipotent stem cell
has OBO namespace: cell
id: CL:0000048

common myeloid progenitor
type: Class
subclass of: hematopoietic oligopotent progenitor cell
disjoint with: megakaryocyte-erythroid progenitor cell
disjoint with: common lymphoid progenitor
disjoint with: granulocyte monocyte progenitor cell
IAO_0000115: A progenitor cell committed to myeloid lineage, including the megakaryocyte and erythroid lineages.
database_cross_reference: BTO:0004730
has exact synonym: CMP
has exact synonym: common myeloid precursor
has OBO namespace: cell
has related synonym: CFU-GEMM
has related synonym: CFU-S
has related synonym: colony forming unit granulocyte, erythrocyte, macrophage, and megakaryocyte
has related synonym: multipotential myeloid stem cell
has related synonym: myeloid stem cell
has related synonym: pluripotent stem cell (bone marrow)
id: CL:0000049
comment: This cell type is intended to be compatible with any vertebrate common myeloid progenitor. For mammalian CMP known to be CD34-positive, please use the term 'common myeloid progenitor, CD34-positive' (CL_0001059).

megakaryocyte-erythroid progenitor cell
type: Class
equivalent class: Class
  intersection of: hematopoietic oligopotent progenitor cell
  intersection of: Restriction
    on property: capable of
    some values from: GO_0030218
  intersection of: Restriction
    on property: capable of
    some values from: GO_0030219
subclass of: myeloid cell
subclass of: hematopoietic oligopotent progenitor cell
subclass of: precursor cell
subclass of: Restriction
  on property: develops_from
  some values from: common myeloid progenitor
subclass of: Restriction
  on property: capable of
  some values from: GO_0030218
subclass of: Restriction
  on property: capable of
  some values from: GO_0030219
disjoint with: granulocyte monocyte progenitor cell
disjoint with: macrophage dendritic cell progenitor
IAO_0000115: A progenitor cell committed to the megakaryocyte and erythroid lineages.
has exact synonym: CFU-EM
has exact synonym: CFU-MegE
has exact synonym: MEP
has exact synonym: Meg/E progenitor
has exact synonym: colony forming unit erythroid megakaryocyte
has exact synonym: megakaryocyte/erythrocyte progenitor
has exact synonym: megakaryocyte/erythroid progenitor cell
has OBO namespace: cell
id: CL:0000050
comment: MEPs are reportedly CD19-negative, CD34-negative, CD45RA-negative, CD110-positive, CD117-positive, and SCA1-negative and reportedly express the transcription factors GATA-1 and NF-E2.

common lymphoid progenitor
type: Class
equivalent class: Class
  intersection of: hematopoietic oligopotent progenitor cell
  intersection of: Restriction
    on property: capable of
    some values from: lymphocyte differentiation
subclass of: hematopoietic oligopotent progenitor cell
subclass of: precursor cell
subclass of: Restriction
  on property: capable of
  some values from: lymphocyte differentiation
IAO_0000115: A oligopotent progenitor cell committed to the lymphoid lineage.
has alternative id: CL:0000044
has exact synonym: CLP
has exact synonym: common lymphocyte precursor
has exact synonym: common lymphocyte progenitor
has exact synonym: common lymphoid precursor
has OBO namespace: cell
has related synonym: ELP
has related synonym: committed lymphopoietic stem cell
has related synonym: early lymphocyte progenitor
has related synonym: lymphoid stem cell
has related synonym: lymphopoietic stem cell
id: CL:0000051
comment: CLP are CD7-positive, CD10-positive, CD19-negative, CD34-positive, CD45RA-positive, CD79a-negative, CD127-positive, AA4.1-positive, RAG-negative, Sca-1-low, sIgM-negative, sIgD-negative, TdT-negative, Vpre-B-negative, and pre-BCR-negative. Expression of transcription factors include E2A-positive, EBF-positive, Ikaros-negative, PU.1-negative, and Pax5-negative.

totipotent stem cell
type: Class
subclass of: somatic stem cell
IAO_0000115: A stem cell from which all cells of the body can form.
database_cross_reference: FMA:84790
has exact synonym: totipotential stem cell
has OBO namespace: cell
id: CL:0000052

non-terminally differentiated cell
type: Class
subclass of: precursor cell
subclass of: Restriction
  on property: capable of
  some values from: cell differentiation
IAO_0000115: A precursor cell with a limited number of potential fates.
database_cross_reference: BTO:0000125
database_cross_reference: FMA:84782
has exact synonym: blast cell
has OBO namespace: cell
id: CL:0000055
comment: define using PATO mulit-potent or oligopotent?

myoblast
type: Class
subclass of: muscle precursor cell
IAO_0000115: A cell that is commited to differentiating into a muscle cell. Embryonic myoblasts develop from the mesoderm. They undergo proliferation, migrate to their various sites, and then differentiate into the appropriate form of myocytes. Myoblasts also occur as transient populations of cells in muscles undergoing repair.
database_cross_reference: BTO:0000222
database_cross_reference: CALOHA:TS-0650
database_cross_reference: FBbt:00005083
database_cross_reference: FMA:70335
database_cross_reference: VHOG:0001529
has OBO namespace: cell
id: CL:0000056

fibroblast
type: Class
subclass of: BFO_0000004
subclass of: connective tissue cell
subclass of: Restriction
  on property: develops_from
  some values from: mesenchymal stem cell
IAO_0000115: A connective tissue cell which secretes an extracellular matrix rich in collagen and other macromolecules. Flattened and irregular in outline with branching processes; appear fusiform or spindle-shaped.
database_cross_reference: BTO:0000452
database_cross_reference: CALOHA:TS-0362
database_cross_reference: FMA:63877
database_cross_reference: VHOG:0001482
has OBO namespace: cell
id: CL:0000057
comment: These cells may be vimentin-positive, fibronectin-positive, fsp1-positive, MMP-1-positive, collagen I-positive, collagen III-positive, and alpha-SMA-negative.

chondroblast
type: Class
subclass of: non-terminally differentiated cell
subclass of: connective tissue cell
subclass of: Restriction
  on property: develops_from
  some values from: prechondroblast
IAO_0000115: Skeletogenic cell that is typically non-terminally differentiated, secretes an avascular, GAG rich matrix; is not buried in cartilage tissue matrix, retains the ability to divide, located adjacent to cartilage tissue (including within the perichondrium), and develops from prechondroblast (and thus prechondrogenic) cell.
database_cross_reference: BTO:0003607
database_cross_reference: FMA:66783
has exact synonym: chrondoplast
has OBO namespace: cell
id: CL:0000058

odontoblast
type: Class
subclass of: non-terminally differentiated cell
subclass of: neurecto-epithelial cell
subclass of: general ecto-epithelial cell
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0005176
subclass of: Restriction
  on property: develops_from
  some values from: preodontoblast
IAO_0000115: Skeletogenic cell that secretes dentine matrix, is derived from the odontogenic papilla, and develops from a preodontoblast cell.
database_cross_reference: BTO:0001769
database_cross_reference: CALOHA:TS-0696
database_cross_reference: FMA:62999
has OBO namespace: cell
id: CL:0000060
comment: legacy def: One of the cells forming the outer surface of dental pulp that produces tooth dentin.

osteoblast
type: Class
subclass of: non-terminally differentiated cell
subclass of: connective tissue cell
subclass of: Restriction
  on property: develops_from
  some values from: preosteoblast
IAO_0000115: Skeletogenic cell that secretes osteoid, is capable of producing mineralized (hydroxyapatite) matrix, is located adjacent to or within osteoid tissue, and arises from the transformation of a preosteoblast cell.
database_cross_reference: BTO:0001593
database_cross_reference: CALOHA:TS-0720
database_cross_reference: FMA:66780
has OBO namespace: cell
id: CL:0000062
comment: non-encoded relationships from VSAO - capable_of_producing VSAO:0000020

ciliated cell
type: Class
subclass of: native cell
IAO_0000115: A cell that has a filiform extrusion of the cell surface.
database_cross_reference: VHOG:0001532
database_cross_reference: XAO:0000031
has OBO namespace: cell
id: CL:0000064

ependymal cell
type: Class
subclass of: ciliated epithelial cell
subclass of: neurecto-epithelial cell
IAO_0000115: A neurectoderm derived cell that lines the neural lumen.
database_cross_reference: BTO:0001724
database_cross_reference: FMA:70550
has exact synonym: ependymocyte
has OBO namespace: cell
id: CL:0000065

epithelial cell
type: Class
equivalent class: Class
  intersection of: animal cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0000483
subclass of: BFO_0000002
subclass of: animal cell
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0000483
disjoint with: leukocyte
IAO_0000115: A cell that is usually found in a two-dimensional sheet with a free surface. The cell has a cytoskeleton that allows for tight cell to cell contact and for cell polarity where apical part is directed towards the lumen and the basal part to the basal lamina.
database_cross_reference: BTO:0000414
database_cross_reference: CALOHA:TS-2026
database_cross_reference: CARO:0000077
database_cross_reference: FBbt:00000124
database_cross_reference: FMA:66768
database_cross_reference: WBbt:0003672
has exact synonym: epitheliocyte
has OBO namespace: cell
id: CL:0000066

ciliated epithelial cell
type: Class
subclass of: ciliated cell
subclass of: columnar/cuboidal epithelial cell
IAO_0000115: An epithelial cell that has a cillia.
database_cross_reference: FMA:70605
has OBO namespace: cell
id: CL:0000067

duct epithelial cell
type: Class
equivalent class: Class
  intersection of: epithelial cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0000058
subclass of: epithelial cell
subclass of: somatic cell
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0000058
has OBO namespace: cell
id: CL:0000068

branched duct epithelial cell
type: Class
subclass of: duct epithelial cell
has OBO namespace: cell
id: CL:0000069

blood vessel endothelial cell
type: Class
equivalent class: Class
  intersection of: squamous epithelial cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0004638
subclass of: squamous epithelial cell
subclass of: endothelial cell of vascular tree
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0004638
subclass of: Restriction
  on property: develops_from
  some values from: embryonic blood vessel endothelial progenitor cell
IAO_0000115: An endothelial cell that lines the vasculature.
has exact synonym: cuboidal endothelial cell of vascular tree
has OBO namespace: cell
id: CL:0000071

non-branched duct epithelial cell
type: Class
subclass of: duct epithelial cell
subclass of: meso-epithelial cell
subclass of: Restriction
  on property: develops_from
  some values from: mesodermal cell
has OBO namespace: cell
id: CL:0000072

columnar/cuboidal epithelial cell
type: Class
subclass of: epithelial cell
subclass of: somatic cell
has OBO namespace: cell
id: CL:0000075

squamous epithelial cell
type: Class
subclass of: epithelial cell
database_cross_reference: CALOHA:TS-1249
has OBO namespace: cell
id: CL:0000076

mesothelial cell
type: Class
subclass of: squamous epithelial cell
subclass of: lining cell
subclass of: meso-epithelial cell
subclass of: Restriction
  on property: develops_from
  some values from: mesodermal cell
IAO_0000115: A flattened epithelial cell of mesenchymal origin that lines the serous cavity.
database_cross_reference: FMA:66773
has exact synonym: mesotheliocyte
has OBO namespace: cell
id: CL:0000077

stratified epithelial cell
type: Class
subclass of: BFO_0000004
subclass of: epithelial cell
subclass of: somatic cell
subclass of: Restriction
  on property: develops_from
  some values from: stratified epithelial stem cell
has OBO namespace: cell
id: CL:0000079

circulating cell
type: Class
equivalent class: Class
  intersection of: native cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0000179
subclass of: BFO_0000002
subclass of: native cell
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0000179
IAO_0000115: A cell which moves among different tissues of the body, via blood, lymph, or other medium.
has OBO namespace: cell
id: CL:0000080

blood cell
type: Class
equivalent class: Class
  intersection of: hematopoietic cell
  intersection of: Restriction
    on property: capable of
    some values from: blood circulation
subclass of: material entity
subclass of: hematopoietic cell
subclass of: Restriction
  on property: capable of
  some values from: blood circulation
IAO_0000115: A cell found predominately in the blood.
database_cross_reference: FMA:62844
has OBO namespace: cell
id: CL:0000081

epithelial cell of lung
type: Class
equivalent class: Class
  intersection of: epithelial cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0002048
subclass of: BFO_0000004
subclass of: epithelial cell
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0000115
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0002048
database_cross_reference: BTO:0004299
has exact synonym: lung epithelial cell
has OBO namespace: cell
id: CL:0000082

epithelial cell of pancreas
type: Class
equivalent class: Class
  intersection of: epithelial cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0001264
subclass of: BFO_0000004
subclass of: epithelial cell
subclass of: somatic cell
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0001264
subclass of: Restriction
  on property: develops_from
  some values from: endodermal cell
IAO_0000115: An epithelial cell of the pancreas.
database_cross_reference: BTO:0000028
has exact synonym: pancreas epithelial cell
has exact synonym: pancreatic epithelial cell
has OBO namespace: cell
id: CL:0000083

T cell
type: Class
equivalent class: Class
  intersection of: lymphocyte
  intersection of: Restriction
    on property: capable of
    some values from: GO_0002456
subclass of: lymphocyte
subclass of: Restriction
  on property: develops_from
  some values from: pro-T cell
subclass of: Restriction
  on property: capable of
  some values from: GO_0002456
disjoint with: natural killer cell
disjoint with: lymphocyte of B lineage
IAO_0000115: A type of lymphocyte whose defining characteristic is the expression of a T cell receptor complex.
has alternative id: CL:0000804
has alternative id: CL:0000812
database_cross_reference: BTO:0000782
database_cross_reference: CALOHA:TS-1001
database_cross_reference: FMA:62870
database_cross_reference: VHOG:0001479
has exact synonym: T lymphocyte
has exact synonym: T-cell
has exact synonym: T-lymphocyte
has OBO namespace: cell
has related synonym: immature T cell
has related synonym: mature T cell
id: CL:0000084

neuron associated cell
type: Class
subclass of: neural cell
subclass of: Restriction
  on property: develops_from
  some values from: neurectodermal cell
has OBO namespace: cell
id: CL:0000095

mast cell
type: Class
subclass of: myeloid leukocyte
subclass of: histamine secreting cell
subclass of: Restriction
  on property: has_part
  some values from: GO_0030141
subclass of: Restriction
  on property: develops_from
  some values from: mast cell progenitor
subclass of: Restriction
  on property: capable of
  some values from: GO_0002349
subclass of: Restriction
  on property: capable of
  some values from: GO_0002539
subclass of: Restriction
  on property: capable of
  some values from: GO_0002660
subclass of: Restriction
  on property: capable of
  some values from: GO_0002690
subclass of: Restriction
  on property: capable of
  some values from: GO_0002830
subclass of: Restriction
  on property: capable of
  some values from: GO_0030210
IAO_0000115: A cell that is found in almost all tissues containing numerous basophilic granules and capable of releasing large amounts of histamine and heparin upon activation. Progenitors leave bone marrow and mature in connective and mucosal tissue. Mature mast cells are found in all tissues, except the bloodstream. Their phenotype is CD117-high, CD123-negative, CD193-positive, CD200R3-positive, and FceRI-high. Stem-cell factor (KIT-ligand; SCF) is the main controlling signal of their survival and development.
database_cross_reference: BTO:0000830
database_cross_reference: CALOHA:TS-0603
database_cross_reference: FMA:66784
has exact synonym: histaminocyte
has exact synonym: labrocyte
has exact synonym: mastocyte
has OBO namespace: cell
has related synonym: tissue basophil
id: CL:0000097
comment: Mast cells are generally integrin beta-7-negative and positive for TLR2, TLR3, TLR4, TLR5, TLR7, TLR9, C3aR, C5aR, CR3, CR4, VEGF, FGF2, and renin. They can express MHC Class I and II on their surface. Activated murine mast cells (IgE+Antigen) were capable of expressing the following co-stimulatory molecules: CD95 (Fas), CD120b, CD137 (4-1BB), CD153 (CD30L), CD154 (CD40L), GITR, ICOSL, OX40L, PD-L1, and PD-L2. Note that there was some mouse strain variation. Mast cells have also been demonstrated to produce bFGF, CCL2, CCL4, CCL5, CCL11, CCL20, CXCL2, CXCL8, CXCL10, GM-CSF, IFN-gamma, IL-1, IL-2, IL-3, IL-8, IL-10, IL-11, IL-12, IL-13, IL-16, IL-25, IL-18, MIP-1, prostaglandin D2, SCF, TGF-beta, TNF-alpha, TSLP, VEGF, and XCL1. They express the transcription factors Transcription factors AP-1, GATA1, MITF, Notch2, PIAS3, PU.1, and STAT5.

sensory epithelial cell
type: Class
equivalent class: Class
  intersection of: epithelial cell
  intersection of: Restriction
    on property: capable of
    some values from: GO_0050906
subclass of: material entity
subclass of: epithelial cell
subclass of: receptor cell
subclass of: somatic cell
subclass of: Restriction
  on property: capable of
  some values from: GO_0050906
IAO_0000115: A specialized epithelial cell involved in sensory perception. Restricted to special sense organs of the olfactory, gustatory, and vestibulocochlear receptor systems; contain sensory cells surrounded by supportive, non-receptive cells.
has broad synonym: neuroepithelial cell
database_cross_reference: BTO:0004301
has OBO namespace: cell
id: CL:0000098
comment: The term "neuroepithelial cell" is used to describe both this cell type and neurecto-epithelial cell (CL:0000710).

interneuron
type: Class
subclass of: neuron
IAO_0000115: Most generally any neuron which is not motor or sensory. Interneurons may also refer to neurons whose axons remain within a particular brain region as contrasted with projection neurons which have axons projecting to other brain regions.
database_cross_reference: BTO:0003811
database_cross_reference: FBbt:00005125
database_cross_reference: FMA:67313
database_cross_reference: WBbt:0005113
has OBO namespace: cell
id: CL:0000099

motor neuron
type: Class
subclass of: efferent neuron
IAO_0000115: An efferent neuron that passes from the central nervous system or a ganglion toward or to a muscle and conducts an impulse that causes or inhibits movement.
database_cross_reference: BTO:0000312
database_cross_reference: FMA:83617
database_cross_reference: WBbt:0005409
has exact synonym: motoneuron
has narrow synonym: anterior horn cell
has OBO namespace: cell
id: CL:0000100

sensory neuron
type: Class
equivalent class: Class
  intersection of: neuron
  intersection of: Restriction
    on property: capable of
    some values from: GO_0050906
subclass of: afferent neuron
subclass of: Restriction
  on property: capable of
  some values from: GO_0050906
IAO_0000115: Any neuron having a sensory function; an afferent neuron conveying sensory impulses.
database_cross_reference: BTO:0001037
database_cross_reference: FBbt:00005124
database_cross_reference: FMA:84649
database_cross_reference: WBbt:0005759
has OBO namespace: cell
id: CL:0000101

autonomic neuron
type: Class
equivalent class: Class
  intersection of: neuron
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0002410
subclass of: peripheral nervous system neuron
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0002410
IAO_0000115: A neruon whose cell body is within an autonomic ganglion.
database_cross_reference: FMA:80121
has OBO namespace: cell
id: CL:0000107

surface ectodermal cell
type: Class
subclass of: ectodermal cell
database_cross_reference: FMA:72552
has exact synonym: cell of surface ectoderm
has exact synonym: surface ectoderm cell
has OBO namespace: cell
id: CL:0000114

endothelial cell
type: Class
subclass of: lining cell
subclass of: meso-epithelial cell
IAO_0000115: An endothelial cell comprises the outermost layer or lining of anatomical structures and can be squamous or cuboidal. In mammals, endothelial cell has vimentin filaments and is derived from the mesoderm.
database_cross_reference: BTO:0001176
database_cross_reference: CALOHA:TS-0278
database_cross_reference: FMA:66772
has exact synonym: endotheliocyte
has OBO namespace: cell
id: CL:0000115
comment: From FMA: 9.07.2001: Endothelial cell has always been classified as a kind of epithelial cell, specifically a squamous cell but that is not true. First, endothelial cell can either be squamous or cuboidal (e.g. high-endothelial cell) and secondly, it has different embryological derivation (mesodermal) than a true epithelial cell (ectodermal and endodermal). The basis for present classification is the fact that it comprises the outermost layer or lining of anatomical structures (location-based) but a better structural basis for the differentia is the cytoskeleton of the cell. Endothelial cell has vimentin filaments while an epithelial cell has keratin filaments. [Onard].

CNS neuron (sensu Vertebrata)
type: Class
subclass of: central nervous system neuron
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0001017
subclass of: Restriction
  on property: develops_from
  some values from: neuroblast (sensu Vertebrata)
has OBO namespace: cell
id: CL:0000117

cerebellar Golgi cell
type: Class
subclass of: CNS interneuron
subclass of: GABAergic interneuron
subclass of: cerebellar neuron
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0002129
IAO_0000115: Large intrinsic neuron located in the granule layer of the cerebellar cortex that extends its dendrites into the molecular layer where they receive contact from parallel fibers. The axon of the Golgi cell enters ramifies densely in the granule layer and enters into a complex arrangement with mossy fiber terminals and granule cell dendrites to form the cerebellar glomerulus. Llinas, Walton and Lang. In The Synaptic Organization of the Brain. 5th ed. 2004.
has exact synonym: Golgi cell
has exact synonym: Golgi neuron
has exact synonym: cerebellar Golgi neuron
has exact synonym: cerebellum Golgi cell
has OBO namespace: cell
id: CL:0000119

granule cell
type: Class
subclass of: CNS neuron (sensu Vertebrata)
database_cross_reference: BTO:0003393
has OBO namespace: cell
id: CL:0000120

neuron associated cell (sensu Vertebrata)
type: Class
subclass of: neuron associated cell
subclass of: Restriction
  on property: develops_from
  some values from: migratory neural crest cell
has OBO namespace: cell
id: CL:0000123

glial cell
type: Class
subclass of: neuron associated cell
subclass of: Restriction
  on property: develops_from
  some values from: glioblast
IAO_0000115: A non-neuronal cell of the nervous system. They not only provide physical support, but also respond to injury, regulate the ionic and chemical composition of the extracellular milieu. Guide neuronal migration during development, and exchange metabolites with neurons.
database_cross_reference: BTO:0002606
database_cross_reference: CALOHA:TS-0415
database_cross_reference: FMA:54536
has exact synonym: neuroglial cell
has OBO namespace: cell
has related synonym: neuroglia
id: CL:0000125

macroglial cell
type: Class
subclass of: glial cell (sensu Vertebrata)
subclass of: Restriction
  on property: develops_from
  some values from: glioblast (sensu Vertebrata)
IAO_0000115: A neuroglial cell of ectodermal origin, i.e., the astrocytes and oligodendrocytes considered together.
database_cross_reference: BTO:0000771
database_cross_reference: CALOHA:TS-2027
database_cross_reference: FMA:54538
has exact synonym: macrogliocyte
has OBO namespace: cell
id: CL:0000126

astrocyte
type: Class
subclass of: macroglial cell
IAO_0000115: A class of large neuroglial (macroglial) cells in the central nervous system - the largest and most numerous neuroglial cells in the brain and spinal cord. Astrocytes (from 'star' cells) are irregularly shaped with many long processes, including those with 'end feet' which form the glial (limiting) membrane and directly and indirectly contribute to the blood-brain barrier. They regulate the extracellular ionic and chemical environment, and 'reactive astrocytes' (along with microglia) respond to injury.
database_cross_reference: BTO:0000099
database_cross_reference: CALOHA:TS-0060
database_cross_reference: FMA:54537
has exact synonym: astrocytic glia
has OBO namespace: cell
id: CL:0000127
comment: Astrocytes are reportedly CD68-negative, CD121a-positive, CD184-positive, CD192-positive, CRF-positive, EGFR-positive, GFAP-positive, GLUT1-positive, MBP-negative, and NGFR-positive.

oligodendrocyte
type: Class
subclass of: macroglial cell
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0001017
subclass of: Restriction
  on property: develops_from
  some values from: oligodendrocyte precursor cell
IAO_0000115: A class of large neuroglial (macroglial) cells in the central nervous system. Form the insulating myelin sheath of axons in the central nervous system.
database_cross_reference: BTO:0000962
database_cross_reference: CALOHA:TS-0709
database_cross_reference: FMA:54540
has exact synonym: OLs
has OBO namespace: cell
has related synonym: oligodendroglia
id: CL:0000128
comment: Oligodendrocytes are reportedly MDP-positive and CD4-negative.

neurectodermal cell
type: Class
subclass of: ectodermal cell
IAO_0000115: Ectoderm destined to be nervous tissue.
has exact synonym: neurectoderm cell
has OBO namespace: cell
id: CL:0000133

mesenchymal stem cell
type: Class
subclass of: multi fate stem cell
subclass of: motile cell
subclass of: connective tissue cell
subclass of: Restriction
  on property: capable of
  some values from: GO_0001649
subclass of: Restriction
  on property: capable of
  some values from: cell migration
subclass of: Restriction
  on property: capable of
  some values from: GO_0030182
subclass of: Restriction
  on property: capable of
  some values from: epithelial cell differentiation
subclass of: Restriction
  on property: capable of
  some values from: GO_0045444
subclass of: Restriction
  on property: capable of
  some values from: GO_0055007
subclass of: Restriction
  on property: capable of
  some values from: GO_0060591
IAO_0000115: A connective tissue cell that normally gives rise to other cells that are organized as three-dimensional masses. This cell type is CD73-positive, CD90-positive, CD105-positive, CD45-negative, CD34-negative, and MHCII-negative. They may further differentiate into osteoblasts, adipocytes, myocytes, neurons, or chondroblasts in vitro. Originally described as residing in the bone marrow, this cell type is now known to reside in many, if not all, adult organs.
has alternative id: CL:0002452
database_cross_reference: BTO:0002625
database_cross_reference: BTO:0003298
database_cross_reference: FMA:70546
has narrow synonym: BMSC
has narrow synonym: bone marrow stromal cells
has narrow synonym: colony-forming unit-fibroblast
has narrow synonym: marrow stromal cells
has OBO namespace: cell
has related synonym: CFU-F
has related synonym: MSC
has related synonym: mesenchymal precursor cell
has related synonym: mesenchymal progenitor cells
has related synonym: mesenchymal stem cell
has related synonym: mesenchymal stromal cell
has related synonym: mesenchymal stromal cells
has related synonym: stem cells, mesenchymal
id: CL:0000134
comment: Many but not all mesenchymal cells derive from the mesoderm. MSCs are reportedly CD3-negative, CD4-negative, CD5-negative, CD8-negative, CD11a-negative, CD11b-negative, CD14-negative, CD19-negative, CD29-positive, CD31-negative, CD34-negative, CD38-negative, CD40-negative, CD44-positive, CD45-negative, CD49-positive, CD54-positive, CD66b-negative, CD79a-negative, CD80-negative, CD102-positive, CD106-positive, CD117-positive, CD121a-positive, CD121b-positive, CD123-positive, CD124-positive, CD133-negative, CD146-positive, CD166-positive, CD271-positive, B220-negative, Gr1-negative, MHCI-positive, MHCII-negative, SSEA4-negative, sca1-positive, Ter119-negative, and glycophorin A-negative. Cultured MSCs are capable of producing stem cell factor, IL7, IL8, IL11, TGF-beta, cofilin, galectin-1, laminin-receptor 1, cyclophilin A, and MMP-2.

fat cell
type: Class
subclass of: BFO_0000004
subclass of: stuff accumulating cell
subclass of: connective tissue cell
subclass of: Restriction
  on property: develops_from
  some values from: mesenchymal stem cell
IAO_0000115: A fat-storing cell found mostly in the abdominal cavity and subcutaneous tissue of mammals. Fat is usually stored in the form of triglycerides.
has alternative id: CL:0000450
database_cross_reference: BTO:0000443
database_cross_reference: CALOHA:TS-0012
database_cross_reference: FMA:63880
has exact synonym: adipocyte
has exact synonym: adipose cell
has OBO namespace: cell
id: CL:0000136

chondrocyte
type: Class
subclass of: glycosaminoglycan secreting cell
subclass of: collagen secreting cell
subclass of: Restriction
  on property: develops_from
  some values from: chondroblast
IAO_0000115: Skeletogenic cell that is terminally differentiated, secretes an avascular, GAG-rich matrix, is embedded in cartilage tissue matrix, retains the ability to divide, and develops from a chondroblast cell.
database_cross_reference: BTO:0000249
database_cross_reference: CALOHA:TS-0138
database_cross_reference: FMA:66782
has exact synonym: cartilage cell
has OBO namespace: cell
id: CL:0000138

professional antigen presenting cell
type: Class
subclass of: material entity
subclass of: defensive cell
subclass of: Restriction
  on property: capable of
  some values from: GO_0002504
IAO_0000115: A cell capable of processing and presenting lipid and protein antigens to T cells in order to initiate an immune response.
has broad synonym: APC
has OBO namespace: cell
id: CL:0000145
comment: Note change of name; nearly all somatic cells can present antigens to T cells via MHC Class I complexes leading to effector responses, but professional antigen presenting cells constitutively express MHC Class II as well as costimulatory molecules, and thus can initiate immune responses via T cells.

pigment cell
type: Class
subclass of: stuff accumulating cell
IAO_0000115: A pigment cell is a cell that contains pigment granules.
database_cross_reference: VHOG:0001678
has exact synonym: chromatocyte
has exact synonym: chromatophore
has OBO namespace: cell
id: CL:0000147

melanocyte
type: Class
equivalent class: Class
  intersection of: pigment cell
  intersection of: Restriction
    on property: has_part
    some values from: GO_0042470
  intersection of: Restriction
    on property: develops_from
    some values from: melanoblast
subclass of: BFO_0000004
subclass of: pigment cell
subclass of: somatic cell
subclass of: Restriction
  on property: has_part
  some values from: GO_0042470
subclass of: Restriction
  on property: develops_from
  some values from: melanoblast
IAO_0000115: A pigment cell derived from the neural crest. Contains melanin-filled pigment granules, which gives a brown to black appearance.
has alternative id: CL:0000572
database_cross_reference: BTO:0000847
database_cross_reference: CALOHA:TS-0613
database_cross_reference: FMA:70545
database_cross_reference: VHOG:0001679
has narrow synonym: melanophore
has OBO namespace: cell
id: CL:0000148

visual pigment cell
type: Class
subclass of: pigment cell
has broad synonym: pigment cell
has OBO namespace: cell
id: CL:0000149

glandular epithelial cell
type: Class
subclass of: epithelial cell
subclass of: secretory cell
subclass of: somatic cell
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0006799
IAO_0000115: A specialized epithelial cell that is capable of synthesizing and secreting certain biomolecules.
database_cross_reference: CALOHA:TS-2085
database_cross_reference: FMA:86494
has OBO namespace: cell
id: CL:0000150

secretory cell
type: Class
equivalent class: Class
  intersection of: native cell
  intersection of: Restriction
    on property: capable of
    some values from: secretion by cell
subclass of: material entity
subclass of: native cell
subclass of: Restriction
  on property: capable of
  some values from: secretion by cell
IAO_0000115: A cell that specializes in controlled release of one or more substances.
database_cross_reference: BTO:0003659
database_cross_reference: FMA:86916
has OBO namespace: cell
id: CL:0000151

exocrine cell
type: Class
equivalent class: Class
  intersection of: secretory cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0002365
subclass of: secretory cell
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0002365
IAO_0000115: A cell of an exocrine gland; i.e. a gland that discharges its secretion via a duct.
database_cross_reference: FMA:16014
has OBO namespace: cell
id: CL:0000152

glycosaminoglycan secreting cell
type: Class
subclass of: extracellular matrix secreting cell
subclass of: carbohydrate secreting cell
IAO_0000115: A cell that secretes glycosaminoglycans.
has exact synonym: GAG secreting cell
has narrow synonym: hyaluronic acid secreting cell
has OBO namespace: cell
id: CL:0000153

protein secreting cell
type: Class
equivalent class: Class
  intersection of: secretory cell
  intersection of: Restriction
    on property: capable of
    some values from: protein secretion
subclass of: secretory cell
subclass of: Restriction
  on property: capable of
  some values from: protein secretion
has OBO namespace: cell
id: CL:0000154

surfactant secreting cell
type: Class
equivalent class: Class
  intersection of: secretory cell
  intersection of: Restriction
    on property: capable of
    some values from: GO_0043129
subclass of: secretory cell
subclass of: Restriction
  on property: capable of
  some values from: GO_0043129
IAO_0000115: A cell that specializes in secretion of surfactant in the alveoli of the lung.
has OBO namespace: cell
id: CL:0000157

Clara cell
type: Class
subclass of: surfactant secreting cell
subclass of: bronchial epithelial cell
subclass of: Restriction
  on property: capable of
  some values from: secretion by cell
subclass of: Restriction
  on property: capable of
  some values from: GO_0043129
IAO_0000115: Epithelial progenitor cell of the lung. Clara cells are dome-shaped with short microvilli but no cilia. They function to protect the bronchiolar epithelium. Clara cells also multiply and differentiate into ciliated cells to regenerate the bronchiolar epithelium.
database_cross_reference: BTO:0004811
database_cross_reference: FMA:14119
has exact synonym: Clara cell of bronchiole
has exact synonym: bronchiolar non-ciliated cell
has OBO namespace: cell
id: CL:0000158

seromucus secreting cell
type: Class
subclass of: secretory cell
has OBO namespace: cell
id: CL:0000159

acid secreting cell
type: Class
equivalent class: Class
  intersection of: secretory cell
  intersection of: Restriction
    on property: capable of
    some values from: acid secretion
subclass of: secretory cell
subclass of: Restriction
  on property: capable of
  some values from: acid secretion
has OBO namespace: cell
id: CL:0000161

endocrine cell
type: Class
equivalent class: Class
  intersection of: secretory cell
  intersection of: Restriction
    on property: capable of
    some values from: GO_0060986
subclass of: secretory cell
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0002368
subclass of: Restriction
  on property: capable of
  some values from: GO_0060986
IAO_0000115: A cell of an endocrine gland, ductless glands that secrete substances which are released directly into the circulation and which influence metabolism and other body functions.
database_cross_reference: FMA:83809
has exact synonym: endocrinocyte
has OBO namespace: cell
id: CL:0000163

enteroendocrine cell
type: Class
subclass of: glandular epithelial cell
subclass of: endocrine cell
IAO_0000115: An endocrine cell that is located in the epithelium of the gastrointestinal tract or in the pancreas.
database_cross_reference: BTO:0003865
database_cross_reference: FMA:62930
has OBO namespace: cell
id: CL:0000164

neuroendocrine cell
type: Class
subclass of: endocrine cell
subclass of: electrically responsive cell
subclass of: neurecto-epithelial cell
IAO_0000115: An endocrine cell that has the specialized function to produce and secrete hormones in response to neuronal signals.
database_cross_reference: BTO:0002691
database_cross_reference: FMA:83810
has exact synonym: neurosecretory cell
has OBO namespace: cell
id: CL:0000165

chromaffin cell
type: Class
subclass of: amine precursor uptake and decarboxylation cell
subclass of: Restriction
  on property: develops_from
  some values from: migratory neural crest cell
IAO_0000115: A cell that stores epinephrine secretory vesicles. During times of stress, the nervous system signals the vesicles to secrete their hormonal content. Their name derives from their ability to stain a brownish color with chromic salts. Characteristically, they are located in the adrenal medulla and paraganglia of the sympathetic nervous system.
database_cross_reference: BTO:0000259
database_cross_reference: FMA:69263
has exact synonym: phaeochromocyte
has OBO namespace: cell
id: CL:0000166

peptide hormone secreting cell
type: Class
equivalent class: Class
  intersection of: secretory cell
  intersection of: Restriction
    on property: capable of
    some values from: peptide hormone secretion
subclass of: secretory cell
subclass of: Restriction
  on property: capable of
  some values from: peptide hormone secretion
has OBO namespace: cell
id: CL:0000167

insulin secreting cell
type: Class
equivalent class: Class
  intersection of: secretory cell
  intersection of: Restriction
    on property: capable of
    some values from: insulin secretion
subclass of: protein secreting cell
subclass of: peptide hormone secreting cell
subclass of: Restriction
  on property: capable of
  some values from: insulin secretion
database_cross_reference: BTO:0000783
has OBO namespace: cell
id: CL:0000168

type B pancreatic cell
type: Class
equivalent class: Class
  intersection of: enteroendocrine cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0000006
  intersection of: Restriction
    on property: capable of
    some values from: insulin secretion
subclass of: epithelial cell of pancreas
subclass of: enteroendocrine cell
subclass of: insulin secreting cell
subclass of: pancreatic endocrine cell
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0000006
subclass of: Restriction
  on property: develops_from
  some values from: progenitor cell of endocrine pancreas
subclass of: Restriction
  on property: capable of
  some values from: insulin secretion
IAO_0000115: A cell that secretes insulin and is located towards the center of the islets of Langerhans.
has broad synonym: beta cell
database_cross_reference: BTO:0000783
database_cross_reference: EV:0200009
database_cross_reference: FMA:70586
database_cross_reference: MA:0002419
database_cross_reference: ncithesaurus:Beta_Cell
has exact synonym: B-cell of pancreatic islet
has exact synonym: beta cell of pancreatic islet
has exact synonym: insulin-secreting cell
has exact synonym: pancreatic B cell
has exact synonym: pancreatic B-cell
has exact synonym: pancreatic beta cell
has exact synonym: pancreatic islet core
has exact synonym: type B enteroendocrine cell
has OBO namespace: cell
has related synonym: beta cell islet
id: CL:0000169
comment: Pancreatic beta cells are also reportedly CD284-positive. Upon activation, they upregulate their CD14 expression.

glucagon secreting cell
type: Class
equivalent class: Class
  intersection of: secretory cell
  intersection of: Restriction
    on property: capable of
    some values from: GO_0070091
subclass of: peptide hormone secreting cell
subclass of: Restriction
  on property: capable of
  some values from: GO_0070091
IAO_0000115: A cell that secretes glucagon.
database_cross_reference: FMA:84045
has exact synonym: glucagon-secreting cell
has OBO namespace: cell
id: CL:0000170

pancreatic A cell
type: Class
equivalent class: Class
  intersection of: type A enterocrine cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0001264
subclass of: epithelial cell of pancreas
subclass of: type A enterocrine cell
subclass of: pancreatic endocrine cell
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0000006
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0001264
subclass of: Restriction
  on property: develops_from
  some values from: progenitor cell of endocrine pancreas
subclass of: Restriction
  on property: capable of
  some values from: GO_0070091
IAO_0000115: A type of enteocrine cell found in the periphery of the islets of Langerhans that secretes glucagon.
database_cross_reference: BTO:0000990
database_cross_reference: FMA:70585
has exact synonym: alpha cell of iselt of Langerhans
has exact synonym: pancreatic alpha cell
has OBO namespace: cell
id: CL:0000171

somatostatin secreting cell
type: Class
equivalent class: Class
  intersection of: secretory cell
  intersection of: Restriction
    on property: capable of
    some values from: GO_0070253
subclass of: peptide hormone secreting cell
subclass of: Restriction
  on property: capable of
  some values from: GO_0070253
has OBO namespace: cell
id: CL:0000172

pancreatic D cell
type: Class
equivalent class: Class
  intersection of: type D enteroendocrine cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0001264
subclass of: epithelial cell of pancreas
subclass of: type D enteroendocrine cell
subclass of: pancreatic endocrine cell
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0000006
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0001264
subclass of: Restriction
  on property: develops_from
  some values from: progenitor cell of endocrine pancreas
IAO_0000115: A D cell located in the pancreas. Peripherally placed within the islets like type A cells; contains somatostatin.
database_cross_reference: BTO:0000803
database_cross_reference: FMA:70587
has exact synonym: D-cell of pancreatic islet
has exact synonym: delta cell of islet
has exact synonym: delta cell of pancreatic islet
has exact synonym: pancreatic D-cell
has exact synonym: pancreatic delta cell
has exact synonym: somatostatin-secreting pancreatic cell
has OBO namespace: cell
id: CL:0000173

steroid hormone secreting cell
type: Class
equivalent class: Class
  intersection of: secretory cell
  intersection of: Restriction
    on property: capable of
    some values from: steroid hormone secretion
subclass of: endocrine cell
subclass of: Restriction
  on property: capable of
  some values from: steroid hormone secretion
has OBO namespace: cell
id: CL:0000174

metabolising cell
type: Class
subclass of: native cell
IAO_0000115: A cell whose primary function is intermediary metabolism.
has OBO namespace: cell
id: CL:0000181

hepatocyte
type: Class
subclass of: material entity
subclass of: epithelial cell
subclass of: metabolising cell
subclass of: endopolyploid cell
subclass of: somatic cell
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0002107
subclass of: Restriction
  on property: develops_from
  some values from: hepatoblast
subclass of: Restriction
  on property: capable of
  some values from: bile acid biosynthetic process
subclass of: Restriction
  on property: capable of
  some values from: cellular metabolic process
subclass of: Restriction
  on property: capable of
  some values from: GO_0098754
IAO_0000115: The main structural component of the liver. They are specialized epithelial cells that are organized into interconnected plates called lobules. Majority of cell population of liver, polygonal in shape, arranged in plates or trabeculae between sinusoids; may have single nucleus or binucleated.
database_cross_reference: BTO:0000575
database_cross_reference: CALOHA:TS-0454
database_cross_reference: FMA:14515
has OBO namespace: cell
id: CL:0000182
comment: Hepatocytes are reportedly MHC Class I-positive and MHC Class II-positive.

contractile cell
type: Class
subclass of: native cell
IAO_0000115: A cell whose primary function is to shorten.
has OBO namespace: cell
id: CL:0000183

myoepithelial cell
type: Class
subclass of: columnar/cuboidal epithelial cell
subclass of: contractile cell
subclass of: meso-epithelial cell
subclass of: Restriction
  on property: develops_from
  some values from: mesodermal cell
IAO_0000115: Contractile cells resembling smooth muscle cells that are present in glands, notably the mammary gland, and aid in secretion. This cell has long weaving dendritic processes containing myofilament.
database_cross_reference: BTO:0002309
database_cross_reference: CALOHA:TS-2379
database_cross_reference: FMA:67799
has exact synonym: basket epithelial cell
has exact synonym: myoepitheliocyte
has OBO namespace: cell
id: CL:0000185

myofibroblast cell
type: Class
subclass of: contractile cell
subclass of: animal cell
subclass of: somatic cell
IAO_0000115: An animal cell that has characteristics of both a fibroblast cell and a smooth muscle cell.
has exact synonym: MFB
has OBO namespace: cell
id: CL:0000186
comment: Myofibroblasts are alpha-SMA-positive, CD34-negative, CD45-negative. They are reportedly capable of secreting IL-1beta, IL-6, and TNF-alpha.

muscle cell
type: Class
subclass of: BFO_0000004
subclass of: contractile cell
subclass of: electrically responsive cell
subclass of: animal cell
subclass of: somatic cell
subclass of: Restriction
  on property: develops_from
  some values from: myoblast
IAO_0000115: A mature contractile cell, commonly known as a myocyte. This cell has as part of its cytoplasm myofibrils organized in various patterns.
database_cross_reference: BTO:0000888
database_cross_reference: BTO:0000902
database_cross_reference: CALOHA:TS-2032
database_cross_reference: FBbt:00005074
database_cross_reference: FMA:67328
database_cross_reference: WBbt:0003675
has exact synonym: muscle fiber
has exact synonym: myocyte
has OBO namespace: cell
id: CL:0000187

cell of skeletal muscle
type: Class
equivalent class: Class
  intersection of: somatic cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0001134
subclass of: BFO_0000004
subclass of: somatic cell
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0001134
IAO_0000115: A somatic cell located in skeletal muscle.
database_cross_reference: BTO:0004392
database_cross_reference: CALOHA:TS-2158
database_cross_reference: FMA:9727
has exact synonym: skeletal muscle cell
has OBO namespace: cell
id: CL:0000188

smooth muscle cell
type: Class
subclass of: non-striated muscle cell
subclass of: visceral muscle cell
subclass of: Restriction
  on property: develops_from
  some values from: smooth muscle myoblast
IAO_0000115: A non-striated, elongated, spindle-shaped cell found lining the digestive tract, uterus, and blood vessels. They develop from specialized myoblasts (smooth muscle myoblast).
has alternative id: CL:0000191
database_cross_reference: BTO:0004576
database_cross_reference: CALOHA:TS-2159
database_cross_reference: FMA:14072
has exact synonym: SMCs
has exact synonym: myocytes, smooth muscle
has exact synonym: smooth muscle fiber
has narrow synonym: non-striated muscle cell
has OBO namespace: cell
id: CL:0000192

receptor cell
type: Class
subclass of: native cell
has OBO namespace: cell
id: CL:0000197

mechanoreceptor cell
type: Class
equivalent class: Class
  intersection of: neuron
  intersection of: Restriction
    on property: capable of
    some values from: GO_0050974
subclass of: sensory neuron
subclass of: Restriction
  on property: capable of
  some values from: GO_0050974
IAO_0000115: A cell specialized to transduce mechanical stimuli and relay that information centrally in the nervous system.
has OBO namespace: cell
has related synonym: mechanoreceptor
id: CL:0000199

chemoreceptor cell
type: Class
equivalent class: Class
  intersection of: neuron
  intersection of: Restriction
    on property: capable of
    some values from: GO_0050907
subclass of: sensory neuron
subclass of: Restriction
  on property: capable of
  some values from: GO_0050907
IAO_0000115: A cell specialized to detect chemical substances and relay that information centrally in the nervous system. Chemoreceptors may monitor external stimuli, as in taste and olfaction, or internal stimuli, such as the concentrations of oxygen and carbon dioxide in the blood.
has OBO namespace: cell
id: CL:0000206

olfactory receptor cell
type: Class
equivalent class: Class
  intersection of: neuron
  intersection of: Restriction
    on property: capable of
    some values from: GO_0050911
subclass of: chemoreceptor cell
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0005725
subclass of: Restriction
  on property: capable of
  some values from: GO_0050911
database_cross_reference: BTO:0004185
database_cross_reference: FMA:67860
database_cross_reference: Wikipedia:Olfactory_receptor_neuron
has exact synonym: Schultze's cell
has exact synonym: odorant receptor cell
has exact synonym: olfactory receptor neuron
has exact synonym: olfactory sensory neuron
has OBO namespace: cell
id: CL:0000207

taste receptor cell
type: Class
equivalent class: Class
  intersection of: neuron
  intersection of: Restriction
    on property: capable of
    some values from: GO_0050912
subclass of: neuronal receptor cell
subclass of: sensory epithelial cell
subclass of: chemoreceptor cell
subclass of: epidermal cell
subclass of: neurecto-epithelial cell
subclass of: endo-epithelial cell
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0002025
subclass of: Restriction
  on property: capable of
  some values from: GO_0050912
IAO_0000115: A cell type found in the spherical or ovoid clusters of receptor cells found mainly in the epithelium of the tongue and constituting the end organs of the sense of taste.
database_cross_reference: FMA:67910
has exact synonym: taste bud cell
has OBO namespace: cell
id: CL:0000209

photoreceptor cell
type: Class
equivalent class: Class
  intersection of: neuron
  intersection of: Restriction
    on property: capable of
    some values from: GO_0050962
subclass of: neuronal receptor cell
subclass of: Restriction
  on property: capable of
  some values from: GO_0050962
IAO_0000115: A cell specialized to detect and transduce light.
database_cross_reference: BTO:0001060
database_cross_reference: CALOHA:TS-0868
database_cross_reference: FBbt:00004211
database_cross_reference: FMA:86740
has OBO namespace: cell
id: CL:0000210

electrically active cell
type: Class
subclass of: native cell
IAO_0000115: A cell whose function is determined by the generation or the reception of an electric signal.
has OBO namespace: cell
id: CL:0000211

absorptive cell
type: Class
subclass of: native cell
IAO_0000115: A cell that takes up and metabolizes substances.
has OBO namespace: cell
id: CL:0000212

lining cell
type: Class
subclass of: barrier cell
IAO_0000115: A cell within an epithelial cell sheet whose main function is to act as an internal or external covering for a tissue or an organism.
has exact synonym: boundary cell
has OBO namespace: cell
id: CL:0000213

synovial cell
type: Class
equivalent class: Class
  intersection of: meso-epithelial cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0002018
subclass of: glycosaminoglycan secreting cell
subclass of: lining cell
subclass of: meso-epithelial cell
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0002018
IAO_0000115: A meso-epithelial cell that lies between the cartilaginous fibers in the synovial membrane of a joint and produces hyaluronic acid.
database_cross_reference: BTO:0003652
database_cross_reference: CALOHA:TS-0995
database_cross_reference: FMA:66786
has exact synonym: synoviocyte
has narrow synonym: hyaluronic acid secreting cell
has OBO namespace: cell
id: CL:0000214

barrier cell
type: Class
subclass of: native cell
IAO_0000115: A cell whose primary function is to prevent the transport of stuff across compartments.
has OBO namespace: cell
id: CL:0000215

Sertoli cell
type: Class
equivalent class: Class
  intersection of: supportive cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0001343
subclass of: androgen binding protein secreting cell
subclass of: supportive cell
subclass of: seminiferous tubule epithelial cell
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0001343
IAO_0000115: A supporting cell projecting inward from the basement membrane of seminiferous tubules. They surround and nourish the developing male germ cells and secrete androgen binding protein. Their tight junctions with the spermatogonia and spermatocytes provide a blood-testis barrier.
database_cross_reference: BTO:0001238
database_cross_reference: CALOHA:TS-0922
database_cross_reference: FMA:72298
database_cross_reference: VHOG:0001348
has OBO namespace: cell
id: CL:0000216

motile cell
type: Class
equivalent class: Class
  intersection of: native cell
  intersection of: Restriction
    on property: capable of
    some values from: cell motility
subclass of: material entity
subclass of: native cell
subclass of: Restriction
  on property: capable of
  some values from: cell motility
IAO_0000115: A cell that moves by its own activities.
has OBO namespace: cell
id: CL:0000219

ectodermal cell
type: Class
subclass of: BFO_0000004
subclass of: embryonic cell
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0000924
IAO_0000115: A cell of the outer of the three germ layers of the embryo.
database_cross_reference: FMA:72549
has exact synonym: ectoderm cell
has OBO namespace: cell
id: CL:0000221

mesodermal cell
type: Class
subclass of: BFO_0000004
subclass of: embryonic cell
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0000926
IAO_0000115: A cell of the middle germ layer of the embryo.
database_cross_reference: FMA:72554
has exact synonym: mesoblast
has exact synonym: mesoderm cell
has OBO namespace: cell
id: CL:0000222

endodermal cell
type: Class
subclass of: BFO_0000004
subclass of: embryonic cell
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0000925
IAO_0000115: A cell of the inner of the three germ layers of the embryo.
database_cross_reference: FMA:72555
has exact synonym: endoderm cell
has OBO namespace: cell
id: CL:0000223

anucleate cell
type: Class
subclass of: native cell
disjoint with: nucleate cell
IAO_0000115: A cell that lacks a nucleus.
database_cross_reference: FMA:68647
has exact synonym: non-nucleated cell
has OBO namespace: cell
id: CL:0000225

single nucleate cell
type: Class
subclass of: nucleate cell
IAO_0000115: A cell with a single nucleus.
has OBO namespace: cell
id: CL:0000226

multinucleate cell
type: Class
subclass of: nucleate cell
IAO_0000115: A cell with more than one nucleus.
database_cross_reference: AEO:0000203
database_cross_reference: WBbt:0008074
has exact synonym: syncitium
has exact synonym: syncytial cell
has exact synonym: syncytium
has OBO namespace: cell
id: CL:0000228

erythrocyte
type: Class
subclass of: blood cell
subclass of: oxygen accumulating cell
subclass of: erythroid lineage cell
subclass of: Restriction
  on property: develops_from
  some values from: reticulocyte
subclass of: Restriction
  on property: capable of
  some values from: blood circulation
subclass of: Restriction
  on property: capable of
  some values from: GO_0015671
IAO_0000115: A red blood cell. In mammals, mature erythrocytes are biconcave disks containing hemoglobin whose function is to transport oxygen.
database_cross_reference: BTO:0000424
database_cross_reference: CALOHA:TS-0290
database_cross_reference: FMA:81100
has exact synonym: RBC
has exact synonym: red blood cell
has OBO namespace: cell
id: CL:0000232

platelet
type: Class
subclass of: blood cell
subclass of: anucleate cell
subclass of: serotonin secreting cell
subclass of: myeloid cell
subclass of: Restriction
  on property: develops_from
  some values from: megakaryocyte
subclass of: Restriction
  on property: capable of
  some values from: blood coagulation
subclass of: Restriction
  on property: capable of
  some values from: blood circulation
IAO_0000115: A non-nucleated disk-shaped cell formed by extrusion from megakaryocytes, found in the blood of all mammals, and mainly involved in blood coagulation.
database_cross_reference: BTO:0000132
database_cross_reference: CALOHA:TS-0803
database_cross_reference: FMA:62851
has exact synonym: anucleate thrombocyte
has exact synonym: blood platelet
has exact synonym: enucleate thrombocyte
has OBO namespace: cell
id: CL:0000233
comment: Platelets are reportedly CCR1-positive, CCR2-negative, CCR3-positive, CCR4-positive, CCR5-negative, CCR6-negative, CCR7-negative, CCR8-negative, CCR9-negative, CCR10-negative, CD16-positive, CD23-positive, CD32-positive, CD40-positive, CD41-positive CD42-positive, CD61-positive, CD62P-positive, CD64-positive, CD89-positive, CD102-positive, CD147-positive (activated platelets), CD154-positive (activated platelets), CD162-positive, CD209, CD282-positive, CD284-positive, CD289-positive, CD181-negative, CD182-negative, CD183-negative, CD184-positive, CLEC2-positive, GPVI-positive, JAMC-positive, PAR1-positive, PAR2-negative, PAR3-positive, PAR4-positive, TSP1-positive, and TXA2R-positive. Platelets can reportedly produce CCL2, CCL3, CCL5, CCL7, CCL17, CD40L, CXCL1, CXCL4, CXCL4L1, CXCL5, CXCL7, CXCL8, CXCL12, EGF, factor V, factor VII, factor XI, factor XIII, bFGF, histamine, IGF-1, IL-1beta, PAI-1, PDGF, plasminogen, protein S, serotonin, TGF-beta, TFPI, VEGF, and vWF.

phagocyte
type: Class
equivalent class: Class
  intersection of: native cell
  intersection of: Restriction
    on property: capable of
    some values from: GO_0006909
subclass of: motile cell
subclass of: stuff accumulating cell
subclass of: defensive cell
subclass of: Restriction
  on property: capable of
  some values from: GO_0006909
IAO_0000115: Any cell capable of ingesting particulate matter via phagocytosis.
database_cross_reference: BTO:0001044
database_cross_reference: FMA:83806
has OBO namespace: cell
id: CL:0000234

macrophage
type: Class
equivalent class: Class
  intersection of: myeloid leukocyte
  intersection of: Restriction
    on property: capable of
    some values from: GO_0006909
  intersection of: Restriction
    on property: capable of
    some values from: GO_0031268
subclass of: phagocyte
subclass of: myeloid leukocyte
subclass of: Restriction
  on property: develops_from
  some values from: monocyte
subclass of: Restriction
  on property: capable of
  some values from: GO_0006909
subclass of: Restriction
  on property: capable of
  some values from: GO_0031268
IAO_0000115: A mononuclear phagocyte present in variety of tissues, typically differentiated from monocytes, capable of phagocytosing a variety of extracellular particulate material, including immune complexes, microorganisms, and dead cells.
database_cross_reference: BTO:0000801
database_cross_reference: CALOHA:TS-0587
database_cross_reference: FMA:63261
database_cross_reference: FMA:83585
has exact synonym: histiocyte
has OBO namespace: cell
id: CL:0000235
comment: Morphology: Diameter 30_M-80 _M, abundant cytoplasm, low N/C ratio, eccentric nucleus. Irregular shape with pseudopods, highly adhesive. Contain vacuoles and phagosomes, may contain azurophilic granules; markers: Mouse & Human: CD68, in most cases CD11b. Mouse: in most cases F4/80+; role or process: immune, antigen presentation, & tissue remodelling; lineage: hematopoietic, myeloid.

B cell
type: Class
equivalent class: Class
  intersection of: lymphocyte of B lineage
  intersection of: Restriction
    on property: capable of
    some values from: GO_0019724
subclass of: lymphocyte of B lineage
subclass of: Restriction
  on property: develops_from
  some values from: pro-B cell
subclass of: Restriction
  on property: capable of
  some values from: GO_0019724
IAO_0000115: A lymphocyte of B lineage with the phenotype CD19-positive, CD20-positive, and capable of B cell mediated immunity.
database_cross_reference: BTO:0000776
database_cross_reference: CALOHA:TS-0068
database_cross_reference: FMA:62869
database_cross_reference: VHOG:0001480
has exact synonym: B lymphocyte
has exact synonym: B-cell
has exact synonym: B-lymphocyte
has OBO namespace: cell
id: CL:0000236

keratinizing barrier epithelial cell
type: Class
subclass of: stratified squamous epithelial cell
subclass of: keratin accumulating cell
subclass of: ecto-epithelial cell
subclass of: Restriction
  on property: develops_from
  some values from: surface ectodermal cell
has OBO namespace: cell
id: CL:0000237

brush border epithelial cell
type: Class
subclass of: columnar/cuboidal epithelial cell
has OBO namespace: cell
id: CL:0000239

stratified squamous epithelial cell
type: Class
subclass of: squamous epithelial cell
subclass of: stratified epithelial cell
has OBO namespace: cell
id: CL:0000240

Merkel cell
type: Class
subclass of: neuron associated cell (sensu Vertebrata)
subclass of: keratinocyte
subclass of: neurecto-epithelial cell
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0002025
IAO_0000115: A modified epidermal cell located in the stratum basale. They are found mostly in areas where sensory perception is acute. Merkel cells are closely associated with an expanded terminal bulb of an afferent myelinated nerve fiber.
database_cross_reference: FMA:70548
has exact synonym: Merkel's cell
has OBO namespace: cell
id: CL:0000242

glial cell (sensu Vertebrata)
type: Class
subclass of: glial cell
subclass of: Restriction
  on property: develops_from
  some values from: glioblast (sensu Vertebrata)
IAO_0000115: A non-neuronal cell of the nervous system. They not only provide physical support, but also respond to injury, regulate the ionic and chemical composition of the extracellular milieu. Form the myelin insulation of nervous pathways, guide neuronal migration during development, and exchange metabolites with neurons. Neuroglia have high-affinity transmitter uptake systems, voltage-dependent and transmitter-gated ion channels, and can release transmitters, but their role in signaling (as in many other functions) is unclear.
has OBO namespace: cell
id: CL:0000243

transitional epithelial cell
type: Class
subclass of: epithelial cell
subclass of: somatic cell
IAO_0000115: A cell characteristically found lining hollow organs that are subject to great mechanical change due to contraction and distention; originally thought to represent a transition between stratified squamous and columnar epithelium.
database_cross_reference: FMA:66778
has OBO namespace: cell
id: CL:0000244

eukaryotic cell
type: Class
subclass of: native cell
has OBO namespace: cell
id: CL:0000255

eye photoreceptor cell
type: Class
equivalent class: Class
  intersection of: photoreceptor cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0000970
subclass of: photoreceptor cell
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0000970
has OBO namespace: cell
id: CL:0000287

structural cell
type: Class
subclass of: native cell
IAO_0000115: A cell whose primary function is to provide structural support, to provide strength and physical integrity to the organism.
has OBO namespace: cell
id: CL:0000293

somatotropin secreting cell
type: Class
equivalent class: Class
  intersection of: secretory cell
  intersection of: Restriction
    on property: capable of
    some values from: GO_0030252
subclass of: peptide hormone secreting cell
subclass of: Restriction
  on property: capable of
  some values from: GO_0030252
IAO_0000115: A peptide hormone secreting cell that produces growth hormone, somatotropin.
has alternative id: CL:0000471
has exact synonym: growth hormone secreting cell
has exact synonym: somatotrophin secreting cell
has OBO namespace: cell
id: CL:0000295

gamete
type: Class
subclass of: haploid cell
subclass of: germ cell
subclass of: Restriction
  on property: capable of
  some values from: GO_0009566
IAO_0000115: A mature sexual reproductive cell having a single set of unpaired chromosomes.
database_cross_reference: CALOHA:TS-0395
database_cross_reference: FBbt:00005412
database_cross_reference: FMA:18649
has exact synonym: haploid nucleated cell
has OBO namespace: cell
has related synonym: haploid germ cell
id: CL:0000300

crystallin accumulating cell
type: Class
subclass of: stuff accumulating cell
database_cross_reference: FBbt:00004193
has exact synonym: lens cell
has OBO namespace: cell
id: CL:0000306

tracheal epithelial cell
type: Class
equivalent class: Class
  intersection of: epithelial cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0003126
subclass of: epithelial cell of tracheobronchial tree
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0003126
subclass of: Restriction
  on property: develops_from
  some values from: tracheoblast
IAO_0000115: An epithelial cell found in the trachea.
has alternative id: CL:1000474
database_cross_reference: FMA:74793
has exact synonym: tracheocyte
has OBO namespace: cell
id: CL:0000307
comment: This class is for the vertebrate tracheal structure. For the analagous insect cell type, see 'respiratory tube epithelial cell'

keratin accumulating cell
type: Class
subclass of: stuff accumulating cell
has OBO namespace: cell
id: CL:0000311

keratinocyte
type: Class
equivalent class: Class
  intersection of: keratinizing barrier epithelial cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0001003
subclass of: material entity
subclass of: keratinizing barrier epithelial cell
subclass of: epidermal cell
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0001003
subclass of: Restriction
  on property: capable of
  some values from: GO_0002775
subclass of: Restriction
  on property: capable of
  some values from: GO_0002776
subclass of: Restriction
  on property: capable of
  some values from: GO_0090023
IAO_0000115: An epidermal cell which synthesizes keratin and undergoes a characteristic change as it moves upward from the basal layers of the epidermis to the cornified (horny) layer of the skin. Successive stages of differentiation of the keratinocytes forming the epidermal layers are basal cell, spinous or prickle cell, and the granular cell.
has alternative id: CL:0002185
database_cross_reference: BTO:0000667
database_cross_reference: CALOHA:TS-0500
database_cross_reference: FMA:62879
has exact synonym: keratinized cell of epidermis
has exact synonym: malpighian cell
has OBO namespace: cell
id: CL:0000312
comment: Keratinocytes are reportedly CDw210a-negative, CDw210b-positive, CD281-positive, CD282-positive, CD285-positive, IL22Ra1-positive, Human keratinocytes are reportedly capable of secreting BD-2, BD-3, hCAP-18, CXCL1, CXCL5, CXCL8, elafin, MMP-3, NGAL, PDGF-A, S100A7, S100A8, and S100A9. Transcription factors: STAT3-positive.

serous secreting cell
type: Class
subclass of: seromucus secreting cell
IAO_0000115: Columnar glandular cell with irregular nucleus, copious granular endoplasmic reticulum and supranuclear granules. Secretes a watery fluid containing proteins known as serous fluid.
database_cross_reference: BTO:0003687
database_cross_reference: FMA:62511
has exact synonym: serous cell
has OBO namespace: cell
id: CL:0000313

milk secreting cell
type: Class
subclass of: secretory cell
has OBO namespace: cell
id: CL:0000314

sebum secreting cell
type: Class
equivalent class: Class
  intersection of: secretory cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0001821
subclass of: exocrine cell
subclass of: sebaceous gland native cell
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0001821
IAO_0000115: A cell secreting sebun, an oily substance secreted by sebaceous glands, composed of keratin, fat, and cellular debris.
has exact synonym: sebocyte
has OBO namespace: cell
id: CL:0000317

mucus secreting cell
type: Class
equivalent class: Class
  intersection of: secretory cell
  intersection of: Restriction
    on property: capable of
    some values from: GO_0070254
subclass of: seromucus secreting cell
subclass of: Restriction
  on property: capable of
  some values from: GO_0070254
database_cross_reference: BTO:0003689
has exact synonym: mucous cell
has OBO namespace: cell
id: CL:0000319

pneumocyte
type: Class
subclass of: epithelial cell of alveolus of lung
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0004821
IAO_0000115: An epithelial cell that lines the peripheral gas exchange region of the lungs of air-breathing vertebrates.
database_cross_reference: BTO:0000395
database_cross_reference: CALOHA:TS-2168
database_cross_reference: FMA:62499
has exact synonym: alveolar epithelial cell
has exact synonym: pneumonocyte
has OBO namespace: cell
id: CL:0000322

stuff accumulating cell
type: Class
subclass of: native cell
IAO_0000115: A cell that is specialised to accumulate a particular substance(s).
has OBO namespace: cell
id: CL:0000325
in subset: upper level

extracellular matrix secreting cell
type: Class
equivalent class: Class
  intersection of: secretory cell
  intersection of: Restriction
    on property: capable of
    some values from: GO_0070278
subclass of: secretory cell
subclass of: stromal cell
subclass of: Restriction
  on property: capable of
  some values from: GO_0070278
has OBO namespace: cell
id: CL:0000327

oxygen accumulating cell
type: Class
equivalent class: Class
  intersection of: native cell
  intersection of: Restriction
    on property: capable of
    some values from: GO_0015671
subclass of: material entity
subclass of: native cell
subclass of: Restriction
  on property: capable of
  some values from: GO_0015671
has OBO namespace: cell
id: CL:0000329

migratory neural crest cell
type: Class
subclass of: motile cell
subclass of: neural crest cell
subclass of: Restriction
  on property: develops_from
  some values from: premigratory neural crest cell
IAO_0000115: A cell derived from the specialized ectoderm flanking each side of the embryonic neural plate, which after the closure of the neural tube, forms masses of cells that migrate out from the dorsal aspect of the neural tube to spread throughout the body.
database_cross_reference: FMA:86667
has OBO namespace: cell
id: CL:0000333

mesenchyme condensation cell
type: Class
subclass of: mesenchymal cell
IAO_0000115: A mesenchymal cell in embryonic development found in a contracting mass and that gives rise to osteoprogenitors.
has OBO namespace: cell
id: CL:0000335

adrenal medulla chromaffin cell
type: Class
equivalent class: Class
  intersection of: chromaffin cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0001236
subclass of: biogenic amine secreting cell
subclass of: chromaffin cell of adrenal gland
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0001236
subclass of: Restriction
  on property: develops_from
  some values from: migratory trunk neural crest cell
IAO_0000115: A cell found within the adrenal medulla that secrete biogenic amine hormones upon stimulation.
has alternative id: CL:1000422
database_cross_reference: FMA:69262
has exact synonym: medullary chromaffin cell of adrenal gland
has OBO namespace: cell
id: CL:0000336

neuroblast (sensu Vertebrata)
type: Class
subclass of: neuroblast
IAO_0000115: An embryonic cell that develops into a nerve cell or neuron.
has OBO namespace: cell
id: CL:0000337

glioblast (sensu Vertebrata)
type: Class
subclass of: glioblast
subclass of: neuron associated cell (sensu Vertebrata)
IAO_0000115: An early neural cell developing from the early ependymal cell of the neural tube.
database_cross_reference: FMA:70564
has exact synonym: spongioblast
has OBO namespace: cell
id: CL:0000339

scleral cell
type: Class
equivalent class: Class
  intersection of: structural cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0001773
subclass of: BFO_0000004
subclass of: structural cell
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0001773
subclass of: Restriction
  on property: develops_from
  some values from: migratory cranial neural crest cell
IAO_0000115: A cell of the sclera of the eye.
has OBO namespace: cell
id: CL:0000347

choroidal cell of the eye
type: Class
equivalent class: Class
  intersection of: structural cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0001776
subclass of: BFO_0000004
subclass of: structural cell
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0001776
subclass of: Restriction
  on property: develops_from
  some values from: migratory cranial neural crest cell
IAO_0000115: A cell of the choroid of the eye.
has OBO namespace: cell
id: CL:0000348

extraembryonic cell
type: Class
equivalent class: Class
  intersection of: animal cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0000478
subclass of: BFO_0000004
subclass of: animal cell
subclass of: somatic cell
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0000478
has OBO namespace: cell
id: CL:0000349

trophoblast cell
type: Class
equivalent class: Class
  intersection of: extraembryonic cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0000358
subclass of: extraembryonic cell
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0000358
IAO_0000115: A cell lining the outside of the blastocyst. After binding to the endometrium, trophoblast cells develop into two distinct layers, an inner layer of mononuclear cytotrophoblast cells and an outer layer of continuous multinuclear cytoplasm, the syncytiotrophoblast cells, which form the early fetal-maternal interface.
database_cross_reference: FMA:83028
has exact synonym: trophoblastic cell
has OBO namespace: cell
id: CL:0000351

epiblast cell
type: Class
subclass of: totipotent stem cell
IAO_0000115: A cell of the outer layer of a blastula that gives rise to the ectoderm after gastrulation.
has OBO namespace: cell
id: CL:0000352

blastoderm cell
type: Class
subclass of: early embryonic cell
IAO_0000115: An undifferentiated cell produced by early cleavages of the fertilized egg (zygote).
database_cross_reference: BTO:0001473
database_cross_reference: FMA:72551
has exact synonym: blastomere
has OBO namespace: cell
id: CL:0000353

blastemal cell
type: Class
subclass of: multi fate stem cell
database_cross_reference: ncithesaurus:Blastemal_Cell
has exact synonym: blastema cell
has OBO namespace: cell
id: CL:0000354

multi-potent skeletal muscle stem cell
type: Class
equivalent class: Class
  intersection of: multi fate stem cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0001134
subclass of: multi fate stem cell
subclass of: cell of skeletal muscle
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0001134
IAO_0000115: A multifate stem cell found in skeletal muscle than can differentiate into many different cell types, including muscle. Distinct cell type from satellite cell.
database_cross_reference: FMA:86767
has OBO namespace: cell
id: CL:0000355
comment: Multi-potency demonstrated ex vivo. At the time of writing, it is unclear whether the endogenous population differentiates into multiple cell types in vivo.

stratified epithelial stem cell
type: Class
subclass of: epithelial fate stem cell
has OBO namespace: cell
id: CL:0000357

sphincter associated smooth muscle cell
type: Class
equivalent class: Class
  intersection of: smooth muscle cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0004590
subclass of: smooth muscle cell
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0004590
IAO_0000115: A smooth muscle cell that is part of a sphincter. A sphincter is a typically circular muscle that normally maintains constriction of a natural body passage or orifice and which relaxes as required by normal physiological functioning.
has OBO namespace: cell
id: CL:0000358

vascular associated smooth muscle cell
type: Class
equivalent class: Class
  intersection of: smooth muscle cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0002049
subclass of: smooth muscle cell
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0002049
IAO_0000115: A smooth muscle cell assocatiated with the vasculature.
has exact synonym: VSMC
has exact synonym: vascular smooth muscle cell
has OBO namespace: cell
id: CL:0000359

epidermal cell
type: Class
equivalent class: Class
  intersection of: epithelial cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0007376
subclass of: general ecto-epithelial cell
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0007376
IAO_0000115: An epithelial cell of the integument (the outer layer of an organism).
has alternative id: CL:1000396
database_cross_reference: BTO:0001470
database_cross_reference: CALOHA:TS-0283
database_cross_reference: FMA:62411
has exact synonym: cell of epidermis
has narrow synonym: epithelial cell of skin
has OBO namespace: cell
id: CL:0000362

animal zygote
type: Class
subclass of: early embryonic cell
IAO_0000115: Diploid cell produced by the fusion of sperm cell nucleus and egg cell.
has broad synonym: zygote
database_cross_reference: BTO:0000854
database_cross_reference: EHDAA2:0004546
database_cross_reference: FMA:72395
has OBO namespace: cell
id: CL:0000365

tracheoblast
type: Class
subclass of: branched duct epithelial cell
has OBO namespace: cell
id: CL:0000377

neurosecretory neuron
type: Class
equivalent class: Class
  intersection of: neuron
  intersection of: Restriction
    on property: capable of
    some values from: hormone secretion
subclass of: secretory cell
subclass of: efferent neuron
subclass of: Restriction
  on property: capable of
  some values from: hormone secretion
database_cross_reference: FBbt:00005130
has OBO namespace: cell
id: CL:0000381

electrically responsive cell
type: Class
subclass of: electrically active cell
IAO_0000115: A cell whose function is determined by its response to an electric signal.
has OBO namespace: cell
id: CL:0000393

ganglion interneuron
type: Class
equivalent class: Class
  intersection of: interneuron
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0000045
subclass of: interneuron
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0000045
has OBO namespace: cell
id: CL:0000397

CNS interneuron
type: Class
equivalent class: Class
  intersection of: interneuron
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0001017
subclass of: interneuron
subclass of: CNS neuron (sensu Vertebrata)
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0001017
has OBO namespace: cell
id: CL:0000402

electrically signaling cell
type: Class
subclass of: electrically active cell
IAO_0000115: A cell that initiates an electrical signal and passes that signal to another cell.
has OBO namespace: cell
id: CL:0000404

male gamete
type: Class
subclass of: male germ cell
subclass of: gamete
subclass of: Restriction
  on property: capable of
  some values from: GO_0009566
database_cross_reference: BTO:0001277
database_cross_reference: CALOHA:TS-0949
has OBO namespace: cell
id: CL:0000408

polyploid cell
type: Class
subclass of: native cell
IAO_0000115: A cell whose nucleus, or nuclei, each contain more than two haploid genomes.
has OBO namespace: cell
id: CL:0000412

haploid cell
type: Class
subclass of: native cell
IAO_0000115: A cell whose nucleus contains a single haploid genome.
has OBO namespace: cell
id: CL:0000413

endopolyploid cell
type: Class
subclass of: polyploid cell
has OBO namespace: cell
id: CL:0000417

reticular cell
type: Class
subclass of: fibroblast
IAO_0000115: Large, stellate fibroblast found along the network of collagen fibers of the reticulum of the spleen; synthesize the matrix components of the reticulum.
database_cross_reference: FMA:62877
has exact synonym: reticulum cell
has OBO namespace: cell
id: CL:0000432

eccrine cell
type: Class
subclass of: glandular epithelial cell
IAO_0000115: A secretory cell that discharges its product without loss of cytoplasm.
has OBO namespace: cell
id: CL:0000434

gonadtroph
type: Class
subclass of: luteinizing hormone secreting cell
subclass of: basophil cell of pars distalis of adenohypophysis
IAO_0000115: A rounded cell that is usually situated next to sinusoids; secretes follicular stimulating hormone (FSH) and luteinizing hormone (LH).
database_cross_reference: BTO:0002482
database_cross_reference: FMA:83100
has exact synonym: delta basophil
has exact synonym: follicle stimulating hormone secreting cell
has exact synonym: gonadotrope
has exact synonym: gonadotrope cell
has exact synonym: gonadotroph
has exact synonym: gonadotropic cell
has exact synonym: pituitary delta cell
has OBO namespace: cell
id: CL:0000437

luteinizing hormone secreting cell
type: Class
equivalent class: Class
  intersection of: secretory cell
  intersection of: Restriction
    on property: capable of
    some values from: GO_0032275
subclass of: endocrine cell
subclass of: Restriction
  on property: capable of
  some values from: GO_0032275
IAO_0000115: A peptide hormone secreting cell pituitary that produces luteinizing hormone.
has OBO namespace: cell
id: CL:0000438

prolactin secreting cell
type: Class
equivalent class: Class
  intersection of: secretory cell
  intersection of: Restriction
    on property: capable of
    some values from: GO_0070459
subclass of: protein secreting cell
subclass of: peptide hormone secreting cell
subclass of: Restriction
  on property: capable of
  some values from: GO_0070459
IAO_0000115: A peptide hormone cell that secretes prolactin.
has OBO namespace: cell
id: CL:0000439

melanocyte stimulating hormone secreting cell
type: Class
equivalent class: Class
  intersection of: secretory cell
  intersection of: Restriction
    on property: capable of
    some values from: GO_0036160
subclass of: peptide hormone secreting cell
subclass of: Restriction
  on property: capable of
  some values from: GO_0036160
IAO_0000115: A cell of the intermediate pituitary that produces melanocyte stimulating hormone.
database_cross_reference: BTO:0002277
has exact synonym: melanotrope
has exact synonym: melanotroph
has OBO namespace: cell
id: CL:0000440

follicular dendritic cell
type: Class
subclass of: defensive cell
IAO_0000115: A cell with extensive dendritic processes found in the B cell areas (primary follicles and germinal centers) of lymphoid tissue. They are unrelated to the dendritic cell associated with T cells. Follicular dendritic cells have Fc receptors and C3b receptors, but unlike other dendritic cells, they do not process or present antigen in a way that allows recognition by T cells. Instead, they hold antigen in the form of immune complexes on their surfaces for long periods and can present antigen to B cells during an immune response.
database_cross_reference: BTO:0004267
database_cross_reference: FMA:83037
has OBO namespace: cell
id: CL:0000442
comment: Due to its unique lineage and distinct function, this is not a type of dendritic cell; CL:0000451.

calcitonin secreting cell
type: Class
equivalent class: Class
  intersection of: secretory cell
  intersection of: Restriction
    on property: capable of
    some values from: calcitonin secretion
subclass of: peptide hormone secreting cell
subclass of: Restriction
  on property: capable of
  some values from: calcitonin secretion
has OBO namespace: cell
id: CL:0000443

chief cell of parathyroid gland
type: Class
subclass of: peptide hormone secreting cell
subclass of: epithelial cell of parathyroid gland
IAO_0000115: An epithelial cell of the parathyroid gland that is arranged in wide, irregular interconnecting columns; responsible for the synthesis and secretion of parathyroid hormone.
database_cross_reference: BTO:0004712
database_cross_reference: CALOHA:TS-2140
database_cross_reference: FMA:69078
has exact synonym: parathyroid chief cell
has exact synonym: parathyroid gland chief cell
has exact synonym: parathyroid hormone secreting cell
has exact synonym: principal cell of parathyroid gland
has OBO namespace: cell
id: CL:0000446

carbohydrate secreting cell
type: Class
subclass of: secretory cell
has OBO namespace: cell
id: CL:0000447

dendritic cell
type: Class
subclass of: leukocyte
subclass of: Restriction
  on property: has_part
  some values from: GO_0042613
subclass of: Restriction
  on property: capable of
  some values from: GO_0001816
subclass of: Restriction
  on property: capable of
  some values from: GO_0019882
subclass of: Restriction
  on property: capable of
  some values from: regulation of T cell differentiation
disjoint with: lymphocyte
IAO_0000115: A cell of hematopoietic origin, typically resident in particular tissues, specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation. These cells are lineage negative (CD3-negative, CD19-negative, CD34-negative, and CD56-negative).
database_cross_reference: BTO:0002042
database_cross_reference: CALOHA:TS-0194
database_cross_reference: FMA:83036
has OBO namespace: cell
has related synonym: interdigitating cell
has related synonym: veiled cell
id: CL:0000451

Langerhans cell
type: Class
subclass of: myeloid leukocyte
subclass of: conventional dendritic cell
subclass of: Restriction
  on property: develops_from
  some values from: myeloid cell
subclass of: Restriction
  on property: capable of
  some values from: GO_0002828
IAO_0000115: Langerhans cell is a conventional dendritic cell that has plasma membrane part CD207. A Langerhans cell is a stellate dendritic cell of myeloid origin, that appears clear on light microscopy and has a dark-staining, indented nucleus and characteristic inclusions (Birbeck granules) in the cytoplasm; Langerhans cells are found principally in the stratum spinosum of the epidermis, but they also occur in other stratified epithelia and have been identified in the lung, lymph nodes, spleen, and thymus.
database_cross_reference: BTO:0000705
database_cross_reference: CALOHA:TS-2375
database_cross_reference: FMA:63072
has exact synonym: LC
has exact synonym: Langerhans' cell
has OBO namespace: cell
id: CL:0000453
comment: Originally described in the dendritic cell ontology (DC_CL:0000021 )(PMID:19243617). These cells are also CD1a-high, CD14-negative, CD207-positive (langerin), CD324-positive (E-cadherin), and DCIR-positive. They reside in the epidermis.

epinephrine secreting cell
type: Class
equivalent class: Class
  intersection of: secretory cell
  intersection of: Restriction
    on property: capable of
    some values from: GO_0048242
subclass of: biogenic amine secreting cell
subclass of: Restriction
  on property: capable of
  some values from: GO_0048242
IAO_0000115: A cell capable of producing epinephrine. Epiniphrine is synthesized from norepiniphrine by the actions of the phenylethanolamine N-methyltransferase enzyme, which is expressed in the adrenal glands, androgenic neurons, and in other cell types.
has exact synonym: adrenaline secreting cell
has exact synonym: epinephrin secreting cell
has OBO namespace: cell
id: CL:0000454

mineralocorticoid secreting cell
type: Class
equivalent class: Class
  intersection of: secretory cell
  intersection of: Restriction
    on property: capable of
    some values from: mineralocorticoid secretion
subclass of: steroid hormone secreting cell
subclass of: Restriction
  on property: capable of
  some values from: mineralocorticoid secretion
has OBO namespace: cell
id: CL:0000456

biogenic amine secreting cell
type: Class
subclass of: secretory cell
has OBO namespace: cell
id: CL:0000457

serotonin secreting cell
type: Class
equivalent class: Class
  intersection of: secretory cell
  intersection of: Restriction
    on property: capable of
    some values from: serotonin secretion
subclass of: biogenic amine secreting cell
subclass of: Restriction
  on property: capable of
  some values from: serotonin secretion
IAO_0000115: A cell type that secretes 5-Hydroxytryptamine (serotonin).
has exact synonym: 5-HT secreting cell
has exact synonym: 5-Hydroxytryptamine secreting cell
has OBO namespace: cell
id: CL:0000458

noradrenergic cell
type: Class
equivalent class: Class
  intersection of: secretory cell
  intersection of: Restriction
    on property: capable of
    some values from: norepinephrine secretion
subclass of: biogenic amine secreting cell
subclass of: Restriction
  on property: capable of
  some values from: norepinephrine secretion
IAO_0000115: A cell capable of producting norepiniphrine. Norepiniphrine is a catecholamine with multiple roles including as a hormone and a neurotransmitter. In addition, epiniphrine is synthesized from norepiniphrine by the actions of the phenylethanolamine N-methyltransferase enzyme.
has exact synonym: noradrenaline secreting cell
has exact synonym: norepinephrin secreting cell
has exact synonym: norepinephrine secreting cell
has OBO namespace: cell
id: CL:0000459

adrenocorticotropic hormone secreting cell
type: Class
equivalent class: Class
  intersection of: secretory cell
  intersection of: Restriction
    on property: capable of
    some values from: GO_0051458
subclass of: endocrine cell
subclass of: peptide hormone secreting cell
subclass of: Restriction
  on property: capable of
  some values from: GO_0051458
IAO_0000115: A peptide hormone secreting cell that produces adrenocorticotropin, or corticotropin.
has alternative id: CL:0000640
has exact synonym: ACTH secreting cell
has exact synonym: adrenocorticotrophic hormone secreting cell
has exact synonym: corticotrophin hormone secreting cell
has exact synonym: corticotropin hormone secreting cell
has exact synonym: corticotropin secreting cell
has OBO namespace: cell
id: CL:0000467

defensive cell
type: Class
subclass of: native cell
IAO_0000115: A cell whose primary function is to protect the organism.
has OBO namespace: cell
id: CL:0000473

thyrotroph
type: Class
subclass of: basophil cell of pars distalis of adenohypophysis
subclass of: Restriction
  on property: capable of
  some values from: GO_0070460
IAO_0000115: A basophil cell of the anterior pituitary that produces thyroid stimulating hormone, thyrotrophin. This cell type is elongated, polygonal and lie in clusters towards the adenohypophyseal center.
database_cross_reference: FMA:83099
has exact synonym: beta-basophil
has exact synonym: thyroid stimulating hormone secreting cell
has exact synonym: thyrotrope
has OBO namespace: cell
id: CL:0000476

connective tissue type mast cell
type: Class
equivalent class: Class
  intersection of: mast cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0002384
subclass of: mast cell
subclass of: connective tissue cell
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0002384
IAO_0000115: Mast cell subtype whose granules contain both the serine proteases tryptase and chymase. These cells are primarily found in connective tissue, such as the peritoneal cavity, skin, and intestinal submucosa. Their development is T-cell independent.
has exact synonym: MC(TC)
has exact synonym: MCTC
has exact synonym: TC mast cells
has OBO namespace: cell
id: CL:0000484
comment: They are CD88-positive. The cytoplasmic granules contain high levels of histamine and heparin (mouse) or major neutral proteases, tryptase, chymase, carboxypeptidase A, and cathepsin G (humans). Reportedly, they cannot produce leukotrienes (LTC4) and IL-4. They are reportedly very heterogeneous depending upon location and can convert to the MC(T) phenotype.

visible light photoreceptor cell
type: Class
equivalent class: Class
  intersection of: photoreceptor cell
  intersection of: Restriction
    on property: capable of
    some values from: detection of visible light
subclass of: photoreceptor cell
subclass of: Restriction
  on property: capable of
  some values from: detection of visible light
IAO_0000115: A photoreceptor cell that detects visible light.
has OBO namespace: cell
id: CL:0000488

stromal cell
type: Class
subclass of: BFO_0000004
subclass of: connective tissue cell
subclass of: Restriction
  on property: develops_from
  some values from: mesenchymal stem cell
IAO_0000115: A connective tissue cell of an organ found in the loose connective tissue. These are most often associated with the uterine mucosa and the ovary as well as the hematopoietic system and elsewhere.
database_cross_reference: BTO:0002064
database_cross_reference: FMA:83624
has OBO namespace: cell
id: CL:0000499

type D enteroendocrine cell
type: Class
subclass of: enteroendocrine cell
subclass of: somatostatin secreting cell
subclass of: Restriction
  on property: capable of
  some values from: GO_0070253
IAO_0000115: A cell found throughout the gastrointestinal tract and in the pancreas. They secrete somatostatin in both an endocrine and paracrine manner. Somatostatin inhibits gastrin, cholecystokinin, insulin, glucagon, pancreatic enzymes, and gastric hydrochloric acid. A variety of substances which inhibit gastric acid secretion (vasoactive intestinal peptide, calcitonin gene-related peptide, cholecystokinin, beta-adrenergic agonists, and gastric inhibitory peptide) are thought to act by releasing somatostatin.
database_cross_reference: FMA:62935
has exact synonym: D cell
has OBO namespace: cell
id: CL:0000502

enkephalin secreting cell
type: Class
subclass of: endorphin secreting cell
IAO_0000115: An endorphine cell that secretes enkephalin.
has OBO namespace: cell
id: CL:0000506

endorphin secreting cell
type: Class
subclass of: peptide hormone secreting cell
IAO_0000115: A peptide hormone secreting cell that secretes endorphin.
has OBO namespace: cell
id: CL:0000507

type G enteroendocrine cell
type: Class
subclass of: enteroendocrine cell
subclass of: enkephalin secreting cell
subclass of: gastrin secreting cell
subclass of: mucous cell of stomach
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0004997
IAO_0000115: An endocrine cell found in the pyloric gland mucosa (antral mucosa) of the stomach of mammals and responsible for the secretion of gastrin and enkephalin. Most abundant in pyloric antrum, pyramidal in form with a narrow apex bearing long microvilli.
database_cross_reference: BTO:0004108
database_cross_reference: FMA:67609
has exact synonym: G cell
has OBO namespace: cell
id: CL:0000508

gastrin secreting cell
type: Class
subclass of: peptide hormone secreting cell
IAO_0000115: A peptide hormone secreting cell that secretes gastrin.
has OBO namespace: cell
id: CL:0000509

androgen binding protein secreting cell
type: Class
subclass of: protein secreting cell
IAO_0000115: A peptide hormone secreting cell that secretes androgen binding protein.
has OBO namespace: cell
id: CL:0000511

cardiac muscle myoblast
type: Class
subclass of: cardiocyte
subclass of: cardiac myoblast
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0001133
IAO_0000115: A precursor cell destined to differentiate into cardiac muscle cell.
has alternative id: CL:0000714
database_cross_reference: FMA:84797
has exact synonym: cardiac muscle progenitor cell
has exact synonym: cardiomyocyte progenitor cell
has OBO namespace: cell
id: CL:0000513

smooth muscle myoblast
type: Class
subclass of: myoblast
IAO_0000115: A precursor cell destined to differentiate into smooth muscle myocytes.
database_cross_reference: FMA:84798
has exact synonym: myoblast, smooth muscle
has OBO namespace: cell
has related synonym: satellite cell
id: CL:0000514

skeletal muscle myoblast
type: Class
subclass of: myoblast
subclass of: Restriction
  on property: develops_from
  some values from: multi-potent skeletal muscle stem cell
IAO_0000115: A myoblast that differentiates into skeletal muscle fibers.
database_cross_reference: FMA:84799
has exact synonym: skeletal myoblast
has OBO namespace: cell
id: CL:0000515

afferent neuron
type: Class
subclass of: neuron
IAO_0000115: A neuron which conveys sensory information centrally from the periphery.
database_cross_reference: FMA:87653
has exact synonym: input neuron
has OBO namespace: cell
id: CL:0000526

efferent neuron
type: Class
subclass of: neuron
IAO_0000115: A neuron which sends impulses peripherally to activate muscles or secretory cells.
has exact synonym: output neuron
has OBO namespace: cell
id: CL:0000527

primary neuron
type: Class
subclass of: neuron
has OBO namespace: cell
id: CL:0000530

primary sensory neuron
type: Class
equivalent class: Class
  intersection of: sensory neuron
  intersection of: primary neuron
subclass of: sensory neuron
subclass of: primary neuron
has OBO namespace: cell
id: CL:0000531

neuron
type: Class
subclass of: material entity
subclass of: electrically responsive cell
subclass of: electrically signaling cell
subclass of: neural cell
subclass of: Restriction
  on property: develops_from
  some values from: neuroblast
subclass of: Restriction
  on property: capable of
  some values from: GO_0019226
IAO_0000115: The basic cellular unit of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the nervous system.
database_cross_reference: BTO:0000938
database_cross_reference: CALOHA:TS-0683
database_cross_reference: FBbt:00005106
database_cross_reference: FMA:54527
database_cross_reference: VHOG:0001483
database_cross_reference: WBbt:0003679
has exact synonym: nerve cell
has OBO namespace: cell
id: CL:0000540
comment: These cells are also reportedly CD4-negative and CD200-positive. They are also capable of producing CD40L and IFN-gamma.

melanoblast
type: Class
subclass of: non-terminally differentiated cell
subclass of: somatic cell
subclass of: Restriction
  on property: develops_from
  some values from: migratory neural crest cell
IAO_0000115: A cell that originates from the neural crest and differentiates into a pigment cell.
database_cross_reference: BTO:0003217
database_cross_reference: FMA:83377
has OBO namespace: cell
id: CL:0000541
comment: Derived from UBERON:0002342 neural crest.

lymphocyte
type: Class
subclass of: nongranular leukocyte
subclass of: nucleate cell
subclass of: Restriction
  on property: has_part
  some values from: CP_0000000
subclass of: Restriction
  on property: has_part
  some values from: CP_0000037
subclass of: Restriction
  on property: has_part
  some values from: GO_0000792
subclass of: Restriction
  on property: develops_from
  some values from: common lymphoid progenitor
disjoint with: myeloid leukocyte
IAO_0000115: A lymphocyte is a leukocyte commonly found in the blood and lymph that has the characteristics of a large nucleus, a neutral staining cytoplasm, and prominent heterochromatin.
database_cross_reference: BTO:0000775
database_cross_reference: CALOHA:TS-0583
database_cross_reference: FMA:62863
database_cross_reference: VHOG:0001535
has OBO namespace: cell
id: CL:0000542
comment: Editors note: consider adding taxon constraint to vertebrata (PMID:18025161)

proerythroblast
type: Class
subclass of: erythroid lineage cell
subclass of: nucleate cell
subclass of: Restriction
  on property: has_part
  some values from: CP_0000028
subclass of: Restriction
  on property: has_part
  some values from: CP_0000037
subclass of: Restriction
  on property: has_part
  some values from: nucleus
subclass of: Restriction
  on property: has_part
  some values from: GO_0005730
subclass of: Restriction
  on property: develops_from
  some values from: erythroid progenitor cell
IAO_0000115: An immature, nucleated erythrocyte occupying the stage of erythropoeisis that follows formation of erythroid progenitor cells. This cell is CD71-positive, has both a nucleus and a nucleolus, and lacks hematopoeitic lineage markers.
database_cross_reference: FMA:83518
has exact synonym: rubriblast
has OBO namespace: cell
has related synonym: pronormoblast
id: CL:0000547

animal cell
type: Class
subclass of: eukaryotic cell
has OBO namespace: cell
id: CL:0000548
in subset: upper level

basophilic erythroblast
type: Class
subclass of: erythroblast
subclass of: Restriction
  on property: has_part
  some values from: CP_0000028
subclass of: Restriction
  on property: has_part
  some values from: GO_0000792
subclass of: Restriction
  on property: develops_from
  some values from: proerythroblast
IAO_0000115: A nucleated immature erythrocyte, having cytoplasm generally similar to that of the earlier proerythroblast but sometimes even more basophilic, and usually regular in outline. The nucleus is still relatively large, but the chromatin strands are thicker and more deeply staining, giving a coarser appearance; the nucleoli have disappeared. This cell is CD71-positive and lacks hematopoeitic lineage markers.
database_cross_reference: FMA:83505
has exact synonym: basophilic normoblast
has exact synonym: early erythroblast
has exact synonym: early normoblast
has exact synonym: prorubricyte
has OBO namespace: cell
id: CL:0000549

polychromatophilic erythroblast
type: Class
subclass of: erythroblast
subclass of: Restriction
  on property: has_part
  some values from: CP_0000035
subclass of: Restriction
  on property: has_part
  some values from: GO_0000792
subclass of: Restriction
  on property: develops_from
  some values from: basophilic erythroblast
IAO_0000115: A nucleated, immature erythrocyte in which the nucleus occupies a relatively smaller part of the cell than in its precursor, the basophilic erythroblast. The cytoplasm is beginning to acquire hemoglobin and thus is no longer a purely basophilic, but takes on acidophilic aspects, which becomes progressively more marked as the cell matures. The chromatin of the nucleus is arranged in coarse, deeply staining clumps. This cell is CD71-positive and lacks hematopoeitic lineage markers.
database_cross_reference: FMA:83506
has exact synonym: intermediate erythroblast
has exact synonym: intermediate normoblast
has exact synonym: polychromatic erythroblast
has exact synonym: polychromatic normoblast
has exact synonym: polychromatophilic normoblast
has exact synonym: rubricyte
has OBO namespace: cell
id: CL:0000550

orthochromatic erythroblast
type: Class
subclass of: erythroblast
subclass of: Restriction
  on property: has_part
  some values from: CP_0000027
subclass of: Restriction
  on property: develops_from
  some values from: polychromatophilic erythroblast
IAO_0000115: The final stage of the nucleated, immature erythrocyte, before nuclear loss. Typically the cytoplasm is described as acidophilic, but it still shows a faint polychromatic tint. The nucleus is small and initially may still have coarse, clumped chromatin, as in its precursor, the polychromatophilic erythroblast, but ultimately it becomes pyknotic, and appears as a deeply staining, blue-black, homogeneous structureless mass. The nucleus is often eccentric and sometimes lobulated.
database_cross_reference: FMA:84646
has exact synonym: acidophilic erythroblast
has exact synonym: eosinophilic erythroblast
has exact synonym: late erythoblast
has exact synonym: orthochromatic normoblast
has exact synonym: pyknotic eto enrythroblast
has OBO namespace: cell
id: CL:0000552

megakaryocyte progenitor cell
type: Class
subclass of: myeloid cell
subclass of: myeloid lineage restricted progenitor cell
subclass of: Restriction
  on property: develops_from
  some values from: megakaryocyte-erythroid progenitor cell
subclass of: Restriction
  on property: capable of
  some values from: GO_0007113
subclass of: Restriction
  on property: capable of
  some values from: GO_0030219
IAO_0000115: The earliest cytologically identifiable precursor in the thrombocytic series. This cell is capable of endomitosis and lacks expression of hematopoieitic lineage markers (lin-negative).
database_cross_reference: BTO:0001164
database_cross_reference: CALOHA:TS-0610
database_cross_reference: FMA:84235
has exact synonym: CFU-Meg
has exact synonym: Meg-CFC
has exact synonym: MkP
has exact synonym: colony-forming unit-megakaryocyte
has exact synonym: megacaryoblast
has exact synonym: megacaryocyte progenitor cell
has exact synonym: megakaryoblast
has exact synonym: megakaryocytic progenitor cell
has OBO namespace: cell
has related synonym: promegacaryocyte
has related synonym: promegakaryocyte
id: CL:0000553
comment: Lineage negative is described here as CD2-negative, CD3-negative, CD4-negative, CD5-negative, CD8a-negative, CD14-negative, CD19-negative, CD20-negative, CD56-negative, Ly6g-negative, and Ter119-negative.

neuronal brush cell
type: Class
subclass of: CNS neuron (sensu Vertebrata)
has OBO namespace: cell
id: CL:0000555

megakaryocyte
type: Class
subclass of: myeloid cell
subclass of: bone marrow hematopoietic cell
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0002371
subclass of: Restriction
  on property: develops_from
  some values from: megakaryocyte progenitor cell
disjoint with: erythroid lineage cell
IAO_0000115: A giant cell 50 to 100 micron in diameter, with a greatly lobulated nucleus, found in the bone marrow; mature blood platelets are released from its cytoplasm.
database_cross_reference: BTO:0000843
database_cross_reference: CALOHA:TS-0611
database_cross_reference: FMA:83555
has exact synonym: megacaryocyte
has exact synonym: megalocaryocyte
has exact synonym: megalokaryocyte
has OBO namespace: cell
id: CL:0000556
comment: Megakaryocytes are reportedly CD181-positive and CD182-positive.

granulocyte monocyte progenitor cell
type: Class
subclass of: myeloid cell
subclass of: CD7-negative lymphoid progenitor OR granulocyte monocyte progenitor
subclass of: precursor cell
subclass of: bone marrow hematopoietic cell
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0002371
subclass of: Restriction
  on property: has_part
  some values from: PR_000001944
subclass of: Restriction
  on property: has_part
  some values from: PR_000005307
subclass of: Restriction
  on property: develops_from
  some values from: common myeloid progenitor
subclass of: Restriction
  on property: capable of
  some values from: GO_0030225
subclass of: Restriction
  on property: capable of
  some values from: GO_0030851
IAO_0000115: A hematopoietic progenitor cell that is committed to the granulocyte and monocyte lineages. These cells are CD123-positive, and do not express Gata1 or Gata2 but do express C/EBPa, and Pu.1.
has broad synonym: CFU-C , Colony forming unit in culture
has exact synonym: CFU-GM
has exact synonym: GMP
has exact synonym: colony forming unit granulocyte macrophage
has exact synonym: granulocyte-macrophage progenitor
has exact synonym: granulocyte/monocyte precursor
has exact synonym: granulocyte/monocyte progenitor
has OBO namespace: cell
id: CL:0000557
comment: Originally described in the dendritic cell ontology (DC_CL:0000042)(PMID:19243617). GMPs are reportedly CD16-positive, CD32-positive, CD34-positive, CD38-positive, CD45RA-positive, CD110-negative, CD117-positive, CD123-positive, and SCA1-negative.

reticulocyte
type: Class
subclass of: material entity
subclass of: erythroid lineage cell
subclass of: Restriction
  on property: develops_from
  some values from: orthochromatic erythroblast
subclass of: Restriction
  on property: capable of
  some values from: GO_0071971
IAO_0000115: An immature erythrocyte that changes the protein composition of its plasma membrane by exosome formation and extrusion. The types of protein removed differ between species though removal of the transferrin receptor is apparent in mammals and birds.
database_cross_reference: BTO:0001173
database_cross_reference: CALOHA:TS-0864
has OBO namespace: cell
id: CL:0000558

promonocyte
type: Class
subclass of: myeloid cell
subclass of: monopoietic cell
subclass of: Restriction
  on property: has_part
  some values from: GO_0042582
subclass of: Restriction
  on property: develops_from
  some values from: monoblast
subclass of: Restriction
  on property: capable of
  some values from: GO_0030224
IAO_0000115: A precursor in the monocytic series, being a cell intermediate in development between the monoblast and monocyte. This cell is CD11b-positive and has fine azurophil granules.
database_cross_reference: BTO:0004657
database_cross_reference: FMA:83551
has OBO namespace: cell
id: CL:0000559
comment: Morphology: Mononuclear cell, diameter 14-18 _M, fine azurophilic granules; markers: CD11b (shared with many other myeloid cells); location: Adult: bone marrow; Fetal: Liver, Yolk Sac; role or process: hematopoiesis, monocyte development; lineage: hematopoietic, myeloid.

nucleate erythrocyte
type: Class
equivalent class: Class
  intersection of: erythrocyte
  intersection of: Restriction
    on property: has_part
    some values from: nucleus
subclass of: erythrocyte
subclass of: nucleate cell
subclass of: Restriction
  on property: has_part
  some values from: nucleus
subclass of: Restriction
  on property: develops_from
  some values from: nucleated reticulocyte
IAO_0000115: An erythrocyte having a nucleus.
has broad synonym: RBC
has broad synonym: red blood cell
has OBO namespace: cell
id: CL:0000562

angioblastic mesenchymal cell
type: Class
subclass of: mesenchymal stem cell
subclass of: Restriction
  on property: develops_from
  some values from: mesenchymal stem cell
IAO_0000115: A mesenchymal stem cell capable of developing into blood vessel endothelium.
has exact synonym: angioblast
has exact synonym: chondroplast
has OBO namespace: cell
id: CL:0000566
comment: These cells are reportedly CD31-positive, CD34-positive, CD144-positive, CD309-positive, and TAL1-positive.

amine precursor uptake and decarboxylation cell
type: Class
subclass of: neuroendocrine cell
IAO_0000115: A cell that originates in the neural crest, that has certain cytochemical and ultrastructural characteristics and is found scattered throughout the body; types include melanocytes, the cells of the chromaffin system, and cells in the hypothalamus, hypophysis, thyroid, parathyroids, lungs, gastrointestinal tract, and pancreas. This cell type concentrates the amino acid precursors of certain amines and decarboxylate them, forming amines that function as regulators and neurotransmitters. This cell type produces substances such as epinephrine, norepinephrine, dopamine, serotonin, enkephalin, somatostatin, neurotensin, and substance P, the actions of which may affect contiguous cells, nearby groups of cells, or distant cells, thus functioning as local or systemic hormones. The name is an acronym for amine precursor uptake and decarboxylation cell.
database_cross_reference: BTO:0003866
database_cross_reference: FMA:83114
has exact synonym: APUD cell
has OBO namespace: cell
id: CL:0000568

parafollicular cell
type: Class
subclass of: calcitonin secreting cell
subclass of: serotonin secreting cell
subclass of: neurecto-epithelial cell
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0001747
subclass of: Restriction
  on property: develops_from
  some values from: migratory neural crest cell
subclass of: Restriction
  on property: capable of
  some values from: serotonin secretion
subclass of: Restriction
  on property: capable of
  some values from: GO_0014046
subclass of: Restriction
  on property: capable of
  some values from: calcitonin secretion
IAO_0000115: A neuroepithelial cells that occurs singly or in small groups, close to the outer follicular borders but within the follicular basement membrane of the thyroid. Expresses a form of the neural cell adhesion molecule (N-CAM) on their surface. Secretes calcitonin, 5-hydroxytryptamine and dopamine.
database_cross_reference: FMA:68653
database_cross_reference: SCTID:176770005
has exact synonym: C cell
has exact synonym: C cell of thyroid gland
has exact synonym: clear cell of thyroid gland
has exact synonym: parafollicular cell of thyroid gland
has exact synonym: thyroid parafollicular cell
has OBO namespace: cell
id: CL:0000570

retinal cone cell
type: Class
subclass of: camera-type eye photoreceptor cell
subclass of: Restriction
  on property: develops_from
  some values from: retinal progenitor cell
IAO_0000115: One of the two photoreceptor cell types in the vertebrate retina. In cones the photopigment is in invaginations of the cell membrane of the outer segment. Cones are less sensitive to light than rods, but they provide vision with higher spatial and temporal acuity, and the combination of signals from cones with different pigments allows color vision.
database_cross_reference: BTO:0001036
database_cross_reference: CALOHA:TS-0866
database_cross_reference: FMA:67748
has OBO namespace: cell
id: CL:0000573

corneal epithelial cell
type: Class
equivalent class: Class
  intersection of: squamous epithelial cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0000964
subclass of: squamous epithelial cell
subclass of: general ecto-epithelial cell
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0000964
IAO_0000115: An epithelial cell of the cornea.
has alternative id: CL:1000431
database_cross_reference: BTO:0004298
database_cross_reference: CALOHA:TS-0173
database_cross_reference: FMA:70551
has exact synonym: epithelial cell of cornea
has OBO namespace: cell
id: CL:0000575

monocyte
type: Class
subclass of: myeloid leukocyte
subclass of: mononuclear cell
subclass of: precursor cell
subclass of: Restriction
  on property: develops_from
  some values from: promonocyte
subclass of: Restriction
  on property: capable of
  some values from: GO_0030225
subclass of: Restriction
  on property: capable of
  some values from: GO_0030316
subclass of: Restriction
  on property: capable of
  some values from: GO_0043011
IAO_0000115: Myeloid mononuclear recirculating leukocyte that can act as a precursor of tissue macrophages, osteoclasts and some populations of tissue dendritic cells.
database_cross_reference: BTO:0000876
database_cross_reference: CALOHA:TS-0638
database_cross_reference: FMA:62864
has OBO namespace: cell
id: CL:0000576
comment: Morphology: Mononuclear cell, diameter, 14 to 20 _M, N/C ratio 2:1-1:1. Nucleus may appear in variety of shapes: round, kidney, lobulated, or convoluted. Fine azurophilic granules present; markers: CD11b (shared with other myeloid cells), human: CD14, mouse: F4/80-mid,GR1-low; location: Blood, but can be recruited into tissues; role or process: immune & tissue remodelling; lineage: hematopoietic, myeloid.

enterocyte
type: Class
subclass of: brush border epithelial cell
subclass of: gut absorptive cell
subclass of: intestinal epithelial cell
IAO_0000115: An epithelial cell that has its apical plasma membrane folded into microvilli to provide ample surface for the absorption of nutrients from the intestinal lumen.
database_cross_reference: BTO:0000398
database_cross_reference: FMA:62122
has OBO namespace: cell
id: CL:0000584

germ cell
type: Class
subclass of: germ line cell
subclass of: Restriction
  on property: capable of
  some values from: multicellular organismal reproductive process
IAO_0000115: The reproductive cell in multicellular organisms.
database_cross_reference: BTO:0000535
database_cross_reference: VHOG:0001534
database_cross_reference: WBbt:0006796
has OBO namespace: cell
id: CL:0000586

androgen secreting cell
type: Class
equivalent class: Class
  intersection of: secretory cell
  intersection of: Restriction
    on property: capable of
    some values from: GO_0035935
subclass of: steroid hormone secreting cell
subclass of: Restriction
  on property: capable of
  some values from: GO_0035935
IAO_0000115: A steroid hormone secreting cell that secretes androgen.
has OBO namespace: cell
id: CL:0000593

retinal rod cell
type: Class
subclass of: camera-type eye photoreceptor cell
subclass of: Restriction
  on property: develops_from
  some values from: retinal progenitor cell
IAO_0000115: One of the two photoreceptor cell types of the vertebrate retina. In rods the photopigment is in stacks of membranous disks separate from the outer cell membrane. Rods are more sensitive to light than cones, but rod mediated vision has less spatial and temporal resolution than cone vision.
database_cross_reference: BTO:0001024
database_cross_reference: CALOHA:TS-0870
database_cross_reference: FMA:67747
has OBO namespace: cell
id: CL:0000604

GABAergic neuron
type: Class
equivalent class: Class
  intersection of: neuron
  intersection of: Restriction
    on property: capable of
    some values from: GO_0061534
subclass of: acid secreting cell
subclass of: neuron
subclass of: Restriction
  on property: capable of
  some values from: GO_0061534
IAO_0000115: A neuron that uses GABA as a vesicular neurotransmitter
database_cross_reference: FMA:84788
database_cross_reference: WBbt:0005190
has exact synonym: GABA-ergic neuron
has OBO namespace: cell
id: CL:0000617

acinar cell
type: Class
subclass of: glandular epithelial cell
subclass of: protein secreting cell
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0009842
IAO_0000115: A secretory cell that is grouped together with other cells of the same type to form grape shaped clusters known as acini (singular acinus).
database_cross_reference: FMA:83625
has exact synonym: acinic cell
has exact synonym: acinous cell
has OBO namespace: cell
id: CL:0000622

natural killer cell
type: Class
subclass of: group 1 innate lymphoid cell
subclass of: Restriction
  on property: develops_from
  some values from: pro-NK cell
subclass of: Restriction
  on property: capable of
  some values from: GO_0002228
subclass of: Restriction
  on property: capable of
  some values from: regulation of immune response
IAO_0000115: A lymphocyte that can spontaneously kill a variety of target cells without prior antigenic activation via germline encoded activation receptors and also regulate immune responses via cytokine release and direct contact with other cells.
has broad synonym: large granular lymphocyte
has broad synonym: null cell
database_cross_reference: BTO:0000914
database_cross_reference: BTO:0004716
database_cross_reference: CALOHA:TS-0664
database_cross_reference: FMA:63147
database_cross_reference: FMA:83601
database_cross_reference: VHOG:0001697
has exact synonym: NK cell
has OBO namespace: cell
id: CL:0000623

olfactory granule cell
type: Class
equivalent class: Class
  intersection of: granule cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0002264
subclass of: granule cell
subclass of: neuron of the forebrain
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0002264
IAO_0000115: Granule cell that is part of the olfactory bulb.
has OBO namespace: cell
id: CL:0000626

transporting cell
type: Class
subclass of: native cell
IAO_0000115: A cell involved in transporting nutrients, minerals, water, gases and other chemicals between cells for a variety of purposes including conveying nutrition to other tissues, removing waste products from the tissues, conveying gases for respiration, distributing heat and repelling invasion of foreign substances.
has OBO namespace: cell
id: CL:0000627

supportive cell
type: Class
subclass of: native cell
IAO_0000115: A cell whose primary function is to support other cell types.
database_cross_reference: BTO:0002315
has OBO namespace: cell
id: CL:0000630

chromophil cell of anterior pituitary gland
type: Class
equivalent class: Class
  intersection of: chromaffin cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0002196
subclass of: glandular epithelial cell
subclass of: chromaffin cell
subclass of: peptide hormone secreting cell
subclass of: pituitary gland cell
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0002196
subclass of: Restriction
  on property: capable of
  some values from: peptide hormone secretion
IAO_0000115: A cell that stains readily in the anterior pituitary gland.
database_cross_reference: FMA:83089
has OBO namespace: cell
id: CL:0000637

acidophil cell of pars distalis of adenohypophysis
type: Class
subclass of: chromophil cell of anterior pituitary gland
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0006964
IAO_0000115: An acidophilic chromophil cell that of the anterior pituitary gland.
database_cross_reference: FMA:83093
has exact synonym: acidophil cell of pars anterior of adenohypophysis
has exact synonym: acidophil of pars anterior of adenohypophysis
has exact synonym: acidophil of pars distalis of adenohypophysis
has exact synonym: pituitary alpha cell
has OBO namespace: cell
id: CL:0000638

basophil cell of pars distalis of adenohypophysis
type: Class
subclass of: chromophil cell of anterior pituitary gland
IAO_0000115: A basophillic chromophil cell that of the anterior pituitary gland.
database_cross_reference: FMA:83094
has exact synonym: basophil cell of anterior lobe of hypophysis
has OBO namespace: cell
has related synonym: beta cell
has related synonym: pituitary beta cell
id: CL:0000639

folliculostellate cell
type: Class
subclass of: endocrine cell
subclass of: supportive cell
IAO_0000115: A supportive cell of the vertebrate pituitary that provides macromolecular transport and secretes hormones.
has OBO namespace: cell
id: CL:0000642

basal cell
type: Class
subclass of: epithelial fate stem cell
IAO_0000115: Undifferentiated; mitotic stem cell for other epithelial cell types; rounded or elliptical with little cytoplasm and few organelles; contain cytokeratin intermediate filament.
database_cross_reference: BTO:0000939
database_cross_reference: FMA:62516
has OBO namespace: cell
id: CL:0000646

pinealocyte
type: Class
subclass of: endocrine cell
subclass of: neurecto-epithelial cell
subclass of: neural cell
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0001905
subclass of: Restriction
  on property: capable of
  some values from: melatonin biosynthetic process
IAO_0000115: This cell type produces and secretes melatonin and forms the pineal parenchyma. Extending from each cell body, which has a spherical, oval or lobulated mucleus, are one or more tortuous basophilic processes, containing parallel microtubules known as synaptic ribbons. These processes end in expanded terminal buds near capillaries or less, frequently, ependymal cells of the pineal recess. The terminal buds contain granular endoplasmic reticulum, mitochondria and electron-dense cored vesicles, which store monoamines and polypeptide hormones, release of which appears to require sympathetic innervation.
database_cross_reference: BTO:0001068
database_cross_reference: FMA:83417
has OBO namespace: cell
id: CL:0000652

primary spermatocyte
type: Class
subclass of: spermatocyte
subclass of: Restriction
  on property: capable of
  some values from: GO_0007140
IAO_0000115: A diploid cell that has derived from a spermatogonium and can subsequently begin meiosis and divide into two haploid secondary spermatocytes.
database_cross_reference: BTO:0001115
database_cross_reference: CALOHA:TS-2194
database_cross_reference: FMA:72292
has OBO namespace: cell
id: CL:0000656

secondary spermatocyte
type: Class
subclass of: spermatocyte
subclass of: haploid cell
subclass of: Restriction
  on property: develops_from
  some values from: primary spermatocyte
subclass of: Restriction
  on property: capable of
  some values from: GO_0007142
IAO_0000115: One of the two haploid cells into which a primary spermatocyte divides, and which in turn gives origin to spermatids.
database_cross_reference: BTO:0000709
database_cross_reference: CALOHA:TS-2195
database_cross_reference: FBbt:00004941
database_cross_reference: FMA:72293
has OBO namespace: cell
id: CL:0000657

collagen secreting cell
type: Class
subclass of: extracellular matrix secreting cell
IAO_0000115: An extracellular matrix secreting cell that secretes collagen.
has OBO namespace: cell
id: CL:0000667

pericyte cell
type: Class
subclass of: contractile cell
subclass of: supportive cell
subclass of: connective tissue cell
IAO_0000115: An elongated, contractile cell found wrapped about precapillary arterioles outside the basement membrane. Pericytes are present in capillaries where proper adventitia and muscle layer are missing (thus distingushing this cell type from adventitial cells). They are relatively undifferentiated and may become fibroblasts, macrophages, or smooth muscle cells.
has alternative id: CL:0000184
database_cross_reference: BTO:0002441
database_cross_reference: FMA:63174
has exact synonym: ARC
has exact synonym: adventitial reticular cell
has exact synonym: cell of Rouget
has exact synonym: pericyte
has exact synonym: pericyte of Rouget
has OBO namespace: cell
has related synonym: adventitial cell
id: CL:0000669
comment: Pericytes are CD10-positive, CD13-positive, CD31-negative, CD45-negative, CD106-positive, CD117-negative, CD140-positive, CD144-negative, CD146-positive, CD271-positive, CD325-positive, NG2-positive, RGS5-positive, SMA-positive, and desmin-positive. A subpopulation is CD248-positive. They are also capable of producing angiopoietin 1, CXCL12, TGF-beta, and VEGF-A.

primordial germ cell
type: Class
equivalent class: Class
  intersection of: germ line cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0000922
  intersection of: Restriction
    on property: capable of
    some values from: cell motility
subclass of: germ line cell
subclass of: motile cell
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0000922
subclass of: Restriction
  on property: capable of
  some values from: cell motility
IAO_0000115: A primordial germ cell is a diploid germ cell precursors that transiently exist in the embryo before they enter into close association with the somatic cells of the gonad and become irreversibly committed as germ cells.
database_cross_reference: FMA:70567
has exact synonym: gonocyte
has exact synonym: primitive germ cell
has OBO namespace: cell
id: CL:0000670

gut absorptive cell
type: Class
subclass of: absorptive cell
IAO_0000115: Cell of the intestinal epithelium with a brush border made up of many parallel packed microvilli; associated with absorption, particularly of macromolecules.
has OBO namespace: cell
id: CL:0000677

muscle precursor cell
type: Class
subclass of: non-terminally differentiated cell
subclass of: somatic cell
subclass of: Restriction
  on property: develops_from
  some values from: mesodermal cell
IAO_0000115: A non-terminally differentiated cell that is capable of developing into a muscle cell.
has OBO namespace: cell
id: CL:0000680

PP cell
type: Class
subclass of: enteroendocrine cell
subclass of: peptide hormone secreting cell
IAO_0000115: A cell that stores and secretes pancreatic polypeptide hormone.
database_cross_reference: FMA:62938
database_cross_reference: FMA:83409
has exact synonym: type F enteroendocrine cell
has OBO namespace: cell
id: CL:0000696

choroid plexus epithelial cell
type: Class
equivalent class: Class
  intersection of: ependymal cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0001886
subclass of: ependymal cell
subclass of: transporting cell
subclass of: neural cell
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0001886
IAO_0000115: Specialized ependymal cell that produces the cerebrospinal fluid from the blood and secretes it into the lumen of the brain and spinal chord.
has alternative id: CL:1000430
database_cross_reference: FMA:70549
has exact synonym: epithelial cell of choroid plexus
has OBO namespace: cell
id: CL:0000706

neurecto-epithelial cell
type: Class
equivalent class: Class
  intersection of: ecto-epithelial cell
  intersection of: Restriction
    on property: develops_from
    some values from: neurectodermal cell
subclass of: columnar/cuboidal epithelial cell
subclass of: ecto-epithelial cell
subclass of: Restriction
  on property: develops_from
  some values from: neurectodermal cell
IAO_0000115: Epithelial cells derived from neural plate and neural crest.
has broad synonym: neuroepithelial cell
database_cross_reference: BTO:0004301
database_cross_reference: FMA:70557
has OBO namespace: cell
id: CL:0000710
comment: The term "neuroepithelial cell" is used to describe both this cell type and sensory epithelial cell (CL:0000098).

somatic stem cell
type: Class
equivalent class: Class
  intersection of: stem cell
  intersection of: Restriction
    on property: capable of
    some values from: GO_0048103
subclass of: stem cell
subclass of: somatic cell
subclass of: Restriction
  on property: capable of
  some values from: GO_0048103
IAO_0000115: A stem cell that can give rise to cell types of the body other than those of the germ-line.
database_cross_reference: CALOHA:TS-2086
database_cross_reference: FMA:63368
has OBO namespace: cell
id: CL:0000723

urothelial cell
type: Class
equivalent class: Class
  intersection of: transitional epithelial cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0000365
subclass of: BFO_0000004
subclass of: transitional epithelial cell
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0000365
IAO_0000115: A cell of a layer of transitional epithelium in the wall of the bladder, ureter, and renal pelvis, external to the lamina propria.
database_cross_reference: FMA:84127
has narrow synonym: bladder transitional cell
has narrow synonym: transitional epithelial cell of urinary bladder
has narrow synonym: urinary tract transitional epithelial cell
has OBO namespace: cell
id: CL:0000731

striated muscle cell
type: Class
subclass of: muscle cell
subclass of: Restriction
  on property: has_part
  some values from: GO_0030017
disjoint with: non-striated muscle cell
IAO_0000115: Muscle cell which has as its direct parts myofilaments organized into sarcomeres.
database_cross_reference: BTO:0002916
database_cross_reference: CALOHA:TS-2157
database_cross_reference: FMA:86936
has OBO namespace: cell
id: CL:0000737

leukocyte
type: Class
equivalent class: Class
  intersection of: hematopoietic cell
  intersection of: Restriction
    on property: capable of
    some values from: ameboidal-type cell migration
subclass of: motile cell
subclass of: hematopoietic cell
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0002405
subclass of: Restriction
  on property: develops_from
  some values from: hematopoietic stem cell
subclass of: Restriction
  on property: capable of
  some values from: ameboidal-type cell migration
IAO_0000115: An achromatic cell of the myeloid or lymphoid lineages capable of ameboid movement, found in blood or other tissue.
database_cross_reference: BTO:0000751
database_cross_reference: CALOHA:TS-0549
database_cross_reference: FMA:62852
has exact synonym: immune cell
has exact synonym: leucocyte
has exact synonym: white blood cell
has OBO namespace: cell
id: CL:0000738

retinal ganglion cell
type: Class
subclass of: CNS neuron (sensu Vertebrata)
subclass of: retinal cell
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0000966
IAO_0000115: The set of neurons that receives neural inputs via bipolar, horizontal and amacrine cells. The axons of these cells make up the optic nerve.
database_cross_reference: BTO:0001800
database_cross_reference: FMA:67765
has exact synonym: RGC
has exact synonym: gangliocyte
has exact synonym: ganglion cell of retina
has OBO namespace: cell
id: CL:0000740

cardiac muscle cell
type: Class
subclass of: striated muscle cell
subclass of: cardiocyte
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0007100
subclass of: Restriction
  on property: has_part
  some values from: GO_0030017
subclass of: Restriction
  on property: develops_from
  some values from: cardiac muscle myoblast
IAO_0000115: Cardiac muscle cells are striated muscle cells that are responsible for heart contraction. In mammals, the contractile fiber resembles those of skeletal muscle but are only one third as large in diameter, are richer in sarcoplasm, and contain centrally located instead of peripheral nuclei.
has alternative id: FMA:83808
has broad synonym: cardiocyte
database_cross_reference: BTO:0001539
database_cross_reference: CALOHA:TS-0115
database_cross_reference: FMA:14067
has exact synonym: cardiac muscle fiber
has exact synonym: cardiac myocyte
has exact synonym: cardiomyocyte
has exact synonym: heart muscle cell
has OBO namespace: cell
id: CL:0000746
comment: This class encompasses the muscle cells responsible for heart* contraction in both vertebrates and arthropods. The ultrastucture of a wide range of arthropod heart cells has been examined including spiders, horseshoe crabs, crustaceans (see Sherman, 1973 and refs therein) and insects (see Lehmacher et al (2012) and refs therein). According to these refs, the cells participating in heart contraction in all cases are transversely striated. Insects hearts additionally contain ostial cells, also transversely striated muscle cells, but which do not participate in heart contraction.

myeloid cell
type: Class
equivalent class: Class
  intersection of: hematopoietic cell
  intersection of: Restriction
    on property: develops_from
    some values from: common myeloid progenitor
subclass of: BFO_0000004
subclass of: hematopoietic cell
subclass of: Restriction
  on property: develops_from
  some values from: common myeloid progenitor
IAO_0000115: A cell of the monocyte, granulocyte, mast cell, megakaryocyte, or erythroid lineage.
database_cross_reference: BTO:0001441
database_cross_reference: CALOHA:TS-0647
has OBO namespace: cell
id: CL:0000763

erythroid lineage cell
type: Class
subclass of: myeloid cell
IAO_0000115: A immature or mature cell in the lineage leading to and including erythrocytes.
has alternative id: CL:0002156
database_cross_reference: CALOHA:TS-0290
database_cross_reference: FMA:62845
database_cross_reference: FMA:83516
has exact synonym: erythropoietic cell
has OBO namespace: cell
id: CL:0000764
comment: Note that in FMA erythropoietic cells are types of nucleated erythrocytes and thus don't include erythrocytes.

erythroblast
type: Class
subclass of: erythroid lineage cell
subclass of: nucleate cell
subclass of: precursor cell
subclass of: Restriction
  on property: has_part
  some values from: nucleus
subclass of: Restriction
  on property: develops_from
  some values from: proerythroblast
subclass of: Restriction
  on property: capable of
  some values from: GO_0030218
IAO_0000115: A nucleated precursor of an erythrocyte that lacks hematopoietic lineage markers.
database_cross_reference: BTO:0001571
database_cross_reference: CALOHA:TS-0289
database_cross_reference: FMA:83504
has exact synonym: normoblast
has OBO namespace: cell
id: CL:0000765

myeloid leukocyte
type: Class
equivalent class: Class
  intersection of: leukocyte
  intersection of: Restriction
    on property: develops_from
    some values from: common myeloid progenitor
subclass of: leukocyte
subclass of: myeloid cell
subclass of: Restriction
  on property: develops_from
  some values from: common myeloid progenitor
IAO_0000115: A cell of the monocyte, granulocyte, or mast cell lineage.
has OBO namespace: cell
id: CL:0000766

plasmacytoid dendritic cell
type: Class
equivalent class: Class
  intersection of: dendritic cell
  intersection of: Restriction
    on property: capable of
    some values from: GO_0032606
subclass of: dendritic cell
subclass of: Restriction
  on property: develops_from
  some values from: hematopoietic stem cell
subclass of: Restriction
  on property: capable of
  some values from: GO_0032606
IAO_0000115: A dendritic cell type of distinct morphology, localization, and surface marker expression (CD123-positive) from other dendritic cell types and associated with early stage immune responses, particularly the release of physiologically abundant amounts of type I interferons in response to infection.
database_cross_reference: BTO:0004625
has exact synonym: DC2
has exact synonym: IPC
has exact synonym: T-associated plasma cell
has exact synonym: interferon-producing cell
has exact synonym: lymphoid dendritic cell
has exact synonym: pDC
has exact synonym: plasmacytoid T cell
has exact synonym: plasmacytoid monocyte
has exact synonym: type 2 DC
has OBO namespace: cell
id: CL:0000784

mature B cell
type: Class
subclass of: B cell
subclass of: Restriction
  on property: develops_from
  some values from: transitional stage B cell
subclass of: Restriction
  on property: capable of
  some values from: GO_0002504
subclass of: Restriction
  on property: capable of
  some values from: B cell activation
disjoint with: immature B cell
disjoint with: precursor B cell
disjoint with: transitional stage B cell
IAO_0000115: A B cell that is mature, having left the bone marrow. Initially, these cells are IgM-positive and IgD-positive, and they can be activated by antigen.
has exact synonym: mature B lymphocyte
has exact synonym: mature B-cell
has exact synonym: mature B-lymphocyte
has OBO namespace: cell
id: CL:0000785
comment: Mature B cells are also reportedly CD10-negative, CD19-positive, CD22-positive, CD34-negative, CD48-positive, CD79a-positive, CD84-positive, CD127-negative, CD352-positive, RAG-negative, TdT-negative, Vpre-B-negative, and pre-BCR-negative. Transcription factors expressed: Pax5-positive.

plasma cell
type: Class
subclass of: antibody secreting cell
subclass of: Restriction
  on property: has_part
  some values from: CP_0000043
subclass of: Restriction
  on property: has_part
  some values from: GO_0005794
subclass of: Restriction
  on property: develops_from
  some values from: plasmablast
IAO_0000115: A terminally differentiated, post-mitotic, antibody secreting cell of the B cell lineage with the phenotype CD138-positive, surface immunonoglobulin-negative, and MHC Class II-negative. Plasma cells are oval or round with extensive rough endoplasmic reticulum, a well-developed Golgi apparatus, and a round nucleus having a characteristic cartwheel heterochromatin pattern and are devoted to producing large amounts of immunoglobulin.
database_cross_reference: BTO:0000392
database_cross_reference: FMA:70574
has exact synonym: plasma B cell
has exact synonym: plasma B-cell
has exact synonym: plasmacyte
has exact synonym: plasmocyte
has OBO namespace: cell
has related synonym: effector B cell
has related synonym: effector B-cell
id: CL:0000786
comment: Plasma cells develop in the spleen and migrate to the bone marrow. Plasma cells are also reportedly CD5-negative, CD10-negative, CD19-positive, CD20-negative, CD21-negative, CD22-negative, CD23-negative, CD24-negative, CD25-negative, CD27-positive, CD34-negative, CD38-positive, CD40-positive, CD43-positive, CD45-positive, CD48-positive, CD53-low, CD80-negative, CD81-positive, CD86-positive, CD95-positive, CD196-negative, CD229-positive, CD270-positive, CD352-positive, CD361-positive, and IgD-negative. Transcription factors: BLIMP1-positive, IRF4-positive, PAX5-negative, SpiB-negative, Ets1-negative, and XBP1-positive.

memory B cell
type: Class
subclass of: mature B cell
IAO_0000115: A memory B cell is a mature B cell that is long-lived, readily activated upon re-encounter of its antigenic determinant, and has been selected for expression of higher affinity immunoglobulin. This cell type has the phenotype CD19-positive, CD20-positive, MHC Class II-positive, and CD138-negative.
has exact synonym: memory B lymphocyte
has exact synonym: memory B-cell
has exact synonym: memory B-lymphocyte
has OBO namespace: cell
id: CL:0000787
comment: Memory B-cells are also reportedly CD5-negative, CD10-negative, CD21-positive, CD22-positive, CD23-negative, CD24-positive, CD25-positive, CD27-positive, CD34-negative, CD38-negative, CD40-positive, CD43-negative, CD44-positive, CD45-positive, CD53-positive, CD80-negative, CD81-negative, CD86-positive, and CD196/CCR6-positive.

naive B cell
type: Class
subclass of: mature B cell
subclass of: Restriction
  on property: develops_from
  some values from: transitional stage B cell
IAO_0000115: A naive B cell is a mature B cell that has the phenotype surface IgD-positive, surface IgM-positive, CD20-positive, CD27-negative and that has not yet been activated by antigen in the periphery.
has exact synonym: naive B lymphocyte
has exact synonym: naive B-cell
has exact synonym: naive B-lymphocyte
has OBO namespace: cell
id: CL:0000788
comment: This cell type is compatible with the HIPC Lyoplate markers for 'naive B cell'. Per DSD: Naive B cells are also reportedly CD10-negative, CD19-positive, CD20-positive, CD21-positive, CD22-positive, CD25-negative, CD27-negative, CD34-negative, CD40-positive, CD43-negative, CD45-positive, CD48-positive, CD53-positive, CD80-negative, CD81-positive, CD84-positive, CD86-negative, CD95-negative, CD138-negative, CD150-positive, CD184/CXCR4-positive, CD185/CXCR5-positive, CD196/CCR6-positive, CD200-positive, CD229-positive, CD243-positive, CD289-positive, CD290-positive, CD352-positive, MHCII/HLA-DR-positive, cadherin 9-positive, and sIgH-positive, Transcription factors: Pax5-positive, ETS1-positive, FOXO1A-positive, KLF4-positive, KLF9-positive, MiTF-positive, OBF1-positive, PLZF-positive, and SpiB-positive.

gamma-delta T cell
type: Class
subclass of: T cell
IAO_0000115: A T cell that expresses a gamma-delta T cell receptor complex.
has exact synonym: gamma-delta T lymphocyte
has exact synonym: gamma-delta T-cell
has exact synonym: gamma-delta T-lymphocyte
has exact synonym: gammadelta T cell
has OBO namespace: cell
has related synonym: gd T cell
id: CL:0000798
comment: Note that gamma-delta T cells have both thymic and extrathymic differentiation pathways.

regulatory T cell
type: Class
equivalent class: Class
  intersection of: mature T cell
  intersection of: Restriction
    on property: capable of
    some values from: negative regulation of immune response
subclass of: mature T cell
subclass of: Restriction
  on property: capable of
  some values from: negative regulation of immune response
IAO_0000115: A T cell which regulates overall immune responses as well as the responses of other T cell subsets through direct cell-cell contact and cytokine release.
has broad synonym: suppressor T cell
has broad synonym: suppressor T lymphocyte
has broad synonym: suppressor T-cell
has broad synonym: suppressor T-lymphocyte
database_cross_reference: BTO:0004520
database_cross_reference: FMA:84070
has exact synonym: regulatory T lymphocyte
has exact synonym: regulatory T-cell
has exact synonym: regulatory T-lymphocyte
has OBO namespace: cell
id: CL:0000815
comment: This cell type may express FoxP3 and CD25 and secretes IL-10 and TGF-beta.

immature B cell
type: Class
subclass of: B cell
subclass of: Restriction
  on property: develops_from
  some values from: small pre-B-II cell
IAO_0000115: An immature B cell is a B cell that has the phenotype surface IgM-positive and surface IgD-negative, and have not undergone class immunoglobulin class switching or peripheral encounter with antigen and activation.
has exact synonym: immature B lymphocyte
has exact synonym: immature B-cell
has exact synonym: immature B-lymphocyte
has exact synonym: newly formed B cell
has OBO namespace: cell
id: CL:0000816
comment: Immature B cells are also reportedly CD5-positive, CD10-positive, CD19-positive, CD20-positive, CD21-positive, CD22-positive, CD24-positive, CD25-negative, CD27-negative, CD34-negative, CD38-positive, CD40-positive, CD43-negative, CD45-positive, CD48-positive, CD53-positive, CD79a-positive, CD80-negative, CD81-positive, CD86-negative, CD95-negative, CD127-negative, CD138-negative, CD185-positive, CD196-positive, MHCII/HLA-DR-positive, RAG-positive, TdT-negative, Vpre-B-negative, and preBCR-negative. Transcription factors expressed: Pax5-positive.

precursor B cell
type: Class
subclass of: B cell
disjoint with: pro-B cell
IAO_0000115: A precursor B cell is a B cell with the phenotype CD10-positive.
database_cross_reference: BTO:0001133
database_cross_reference: CALOHA:TS-0819
has OBO namespace: cell
has related synonym: pre-B cell
id: CL:0000817

transitional stage B cell
type: Class
subclass of: B cell
subclass of: Restriction
  on property: develops_from
  some values from: immature B cell
IAO_0000115: An immature B cell of an intermediate stage between the pre-B cell stage and the mature naive stage with the phenotype surface IgM-positive and CD19-positive, and are subject to the process of B cell selection. A transitional B cell migrates from the bone marrow into the peripheral circulation, and then to the spleen.
has exact synonym: transitional B cell
has exact synonym: transitional stage B lymphocyte
has exact synonym: transitional stage B-cell
has exact synonym: transitional stage B-lymphocyte
has narrow synonym: T1 B cell
has narrow synonym: T2 B cell
has narrow synonym: T3 B cell
has OBO namespace: cell
id: CL:0000818
comment: This cell type is compatible with the HIPC Lyoplate markers for 'transitional B cell'.

B-2 B cell
type: Class
subclass of: mature B cell
IAO_0000115: A conventional B cell subject to antigenic stimulation and dependent on T cell help and with a distinct surface marker expression pattern from B-1 B cells. These cells are CD43-negative.
has exact synonym: B-2 B lymphocyte
has exact synonym: B-2 B-cell
has exact synonym: B-2 B-lymphocyte
has exact synonym: B2 B cell
has exact synonym: B2 B lymphocyte
has exact synonym: B2 B-cell
has exact synonym: B2 B-lymphocyte
has exact synonym: B2 cell
has OBO namespace: cell
has related synonym: B-0 B cell
id: CL:0000822
comment: B-2 B cells are reportedly CD48-positive, CD244-negative, and CD352-positive.

pro-NK cell
type: Class
subclass of: lymphoid lineage restricted progenitor cell
subclass of: Restriction
  on property: develops_from
  some values from: common lymphoid progenitor
IAO_0000115: A lymphoid progenitor cell that is committed to the natural killer cell lineage, expressing CD122 (IL-15) receptor, but lacking many of the phenotypic characteristics of later stages of natural killer cell development such as expression of NK activating and inhibitory molecules. In human this cell has the phenotype CD34-positive, CD45RA-positive, CD10-positive, CD117-negative, and CD161 negative.
has exact synonym: NKP
has exact synonym: natural killer cell progenitor
has exact synonym: pro-natural killer cell
has OBO namespace: cell
has related synonym: null cell
has related synonym: preNK cell
id: CL:0000825
comment: Most markers only described for human pro NK cells.

pro-B cell
type: Class
subclass of: lymphoid lineage restricted progenitor cell
subclass of: Restriction
  on property: has_part
  some values from: PR_000001903
subclass of: Restriction
  on property: has_part
  some values from: PR_000006611
subclass of: Restriction
  on property: develops_from
  some values from: common lymphoid progenitor
IAO_0000115: A progenitor cell of the B cell lineage, with some lineage specific activity such as early stages of recombination of B cell receptor genes, but not yet fully committed to the B cell lineage until the expression of PAX5 occurs.
has broad synonym: pre-pro B cell
database_cross_reference: BTO:0003104
has exact synonym: pro-B lymphocyte
has exact synonym: pro-B-cell
has exact synonym: pro-B-lymphocyte
has exact synonym: progenitor B cell
has exact synonym: progenitor B lymphocyte
has exact synonym: progenitor B-cell
has exact synonym: progenitor B-lymphocyte
has OBO namespace: cell
has related synonym: pre-B cell (Philadelphia nomenclature)
id: CL:0000826
comment: Human pro-B cells are reportedly CD10-positive, CD22-positive, CD34-positive, CD38-positive, CD45-low, CD48-positive, CD79a-positive, CD127-positive, CD184-positive, RAG-positive, TdT-positive, Vpre-B-positive, pre-BCR-negative, IgD-negative, and IgM-negative. Transcription factors expressed: Pax5-positive, EBF-positive, E2A-negative, Ikaros-negative, and PU.1-negative.

pro-T cell
type: Class
equivalent class: Class
  intersection of: lymphoid lineage restricted progenitor cell
  intersection of: Restriction
    on property: capable of
    some values from: T cell differentiation
subclass of: lymphoid lineage restricted progenitor cell
subclass of: Restriction
  on property: develops_from
  some values from: common lymphoid progenitor
subclass of: Restriction
  on property: capable of
  some values from: T cell differentiation
IAO_0000115: A lymphoid progenitor cell of the T cell lineage, with some lineage specific marker expression, but not yet fully committed to the T cell lineage.
has exact synonym: pro-T lymphocyte
has exact synonym: progenitor T cell
has narrow synonym: DN1 cell
has narrow synonym: DN1 thymocyte
has narrow synonym: TN1 cell
has OBO namespace: cell
id: CL:0000827

mast cell progenitor
type: Class
subclass of: myeloid cell
subclass of: myeloid lineage restricted progenitor cell
subclass of: Restriction
  on property: has_part
  some values from: PR_000007857
subclass of: Restriction
  on property: has_part
  some values from: PR_000007858
subclass of: Restriction
  on property: develops_from
  some values from: basophil mast progenitor cell
subclass of: Restriction
  on property: capable of
  some values from: GO_0060374
IAO_0000115: A progenitor cell of the mast cell lineage. Markers for this cell are FceRIa-low, CD117-positive, CD9-positive, T1/ST2-positive, SCA1-negative, and lineage-negative.
has exact synonym: MCP
has OBO namespace: cell
has related synonym: CFU-MC
has related synonym: CFU-Mast
has related synonym: colony forming unit mast cell
id: CL:0000831
comment: MCP are CD16-positive, CD32-positive, CD34-positive, CD45-positive, integrin beta-7-positive, and lin-negative (CD2, CD3e, CD4, CD5, CD8a, CD14, CD19, CD20, CD27, integrin alpha-M, ly6c, ly6g, NCAM-1, and ter119). These cells also express the transcription factors GATA-1, GATA-2, and MITF, but not C/EBPa.

hematopoietic multipotent progenitor cell
type: Class
subclass of: BFO_0000004
subclass of: hematopoietic precursor cell
subclass of: Restriction
  on property: develops_from
  some values from: hematopoietic stem cell
disjoint with: hematopoietic oligopotent progenitor cell
IAO_0000115: A hematopoietic multipotent progenitor cell is multipotent, but not capable of long-term self-renewal. These cells are characterized as lacking lineage cell surface markers and being CD34-positive in both mice and humans.
database_cross_reference: BTO:0000725
database_cross_reference: CALOHA:TS-0448
has exact synonym: MPP
has exact synonym: hemopoietic progenitor cell
has OBO namespace: cell
id: CL:0000837
comment: Markers differ between mouse and human.

lymphoid lineage restricted progenitor cell
type: Class
equivalent class: Class
  intersection of: hematopoietic lineage restricted progenitor cell
  intersection of: Restriction
    on property: capable of
    some values from: lymphocyte differentiation
subclass of: hematopoietic lineage restricted progenitor cell
subclass of: precursor cell
subclass of: Restriction
  on property: capable of
  some values from: lymphocyte differentiation
disjoint with: myeloid lineage restricted progenitor cell
IAO_0000115: A progenitor cell restricted to the lymphoid lineage.
has broad synonym: lymphoid progenitor cell
database_cross_reference: BTO:0004731
database_cross_reference: CALOHA:TS-2025
database_cross_reference: FMA:70338
has OBO namespace: cell
id: CL:0000838
comment: Note that this is a class of cell types, not an identified single cell type.

myeloid lineage restricted progenitor cell
type: Class
equivalent class: Class
  intersection of: hematopoietic lineage restricted progenitor cell
  intersection of: Restriction
    on property: capable of
    some values from: GO_0030099
subclass of: hematopoietic lineage restricted progenitor cell
subclass of: precursor cell
subclass of: Restriction
  on property: capable of
  some values from: GO_0030099
IAO_0000115: A progenitor cell restricted to the myeloid lineage.
has broad synonym: myeloid progenitor cell
database_cross_reference: BTO:0004730
database_cross_reference: CALOHA:TS-2099
database_cross_reference: FMA:70339
has OBO namespace: cell
id: CL:0000839
comment: Note that this is a class of cell types, not an identified single cell type.

mononuclear cell
type: Class
subclass of: single nucleate cell
subclass of: nongranular leukocyte
IAO_0000115: A leukocyte with a single non-segmented nucleus in the mature form.
database_cross_reference: BTO:0000878
database_cross_reference: CALOHA:TS-0768
database_cross_reference: FMA:86713
has exact synonym: mononuclear leukocyte
has narrow synonym: peripheral blood mononuclear cell
has OBO namespace: cell
id: CL:0000842

follicular B cell
type: Class
subclass of: B-2 B cell
IAO_0000115: A resting mature B cell that has the phenotype IgM-positive, IgD-positive, CD23-positive and CD21-positive, and found in the B cell follicles of the white pulp of the spleen or the corticol areas of the peripheral lymph nodes. This cell type is also described as being CD19-positive, B220-positive, AA4-negative, CD43-negative, and CD5-negative.
has exact synonym: Fo B cell
has exact synonym: Fo B-cell
has exact synonym: follicular B lymphocyte
has exact synonym: follicular B-cell
has exact synonym: follicular B-lymphocyte
has OBO namespace: cell
id: CL:0000843
comment: Follicular B cells are also reportedly CD48-positive, CD84-positive, CD229-positive, and CD352-positive.

germinal center B cell
type: Class
subclass of: mature B cell
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0001745
subclass of: Restriction
  on property: develops_from
  some values from: follicular B cell
IAO_0000115: A rapidly cycling mature B cell that has distinct phenotypic characteristics and is involved in T-dependent immune responses and located typically in the germinal centers of lymph nodes. This cell type expresses Ly77 after activation.
has exact synonym: GC B cell
has exact synonym: GC B lymphocyte
has exact synonym: GC B-cell
has exact synonym: GC B-lymphocyte
has exact synonym: germinal center B lymphocyte
has exact synonym: germinal center B-cell
has exact synonym: germinal center B-lymphocyte
has OBO namespace: cell
id: CL:0000844
comment: Germinal center B cells are also reportedly CD10-positive, CD19-positive, CD20-positive, CD38-positive, CD44-low, CD45-positive, CD48-positive, CD95-positive, CD352-positive, and HLA-DR-positive. Transcription factors: BCL6-positive, Ets1-positive, IRF8-positive, MTA3-positive, OBF1-positive, PAX5-positive, SpiB-positive, and STAT3-positive.

marginal zone B cell
type: Class
subclass of: mature B cell
subclass of: splenocyte
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0001251
subclass of: Restriction
  on property: capable of
  some values from: GO_0042742
IAO_0000115: A mature B cell that is located in the marginal zone of the spleen with the phenotype CD23-negative and CD21-positive and expressing a B cell receptor usually reactive to bacterial cell wall components or senescent self components such as oxidized-LDL. This cell type is also described as being CD19-positive, B220-positive, IgM-high, AA4-negative, CD35-high.
has exact synonym: MZ B cell
has exact synonym: MZ B lymphocyte
has exact synonym: MZ B-cell
has exact synonym: MZ B-lymphocyte
has exact synonym: marginal zone B lymphocyte
has exact synonym: marginal zone B-cell
has exact synonym: marginal zone B-lymphocyte
has OBO namespace: cell
id: CL:0000845
comment: MZ B cells are reportedly CD1-positive (mice), CD20-positive, CD48-positive, CD84-positive, CD150-positive, CD229-positive, and CD352-positive.

olfactory epithelial support cell
type: Class
equivalent class: Class
  intersection of: supportive cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0001997
subclass of: supportive cell
subclass of: basal cell of olfactory epithelium
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0001997
IAO_0000115: Olfactory epithelial support cell is a columnar cell that extends from the epithelial free margin to the basement membrane of the olfactory epithelium. This cell type has a large, vertically, elongate, euchromatic nucleus, along with other nuclei, forms a layer superficial to the cell body of the receptor cell; sends long somewhat irregular microvilli into the mucus layer; at the base, with expanded end-feet containing numerous lamellated dense bodies resembling lipofuscin of neurons.
database_cross_reference: FMA:62302
has exact synonym: olfactory sustentacular cell
has exact synonym: supporting cell of olfactory epithelium
has exact synonym: sustentaculocyte of olfactory epithelium
has OBO namespace: cell
id: CL:0000853

tissue-resident macrophage
type: Class
equivalent class: Class
  intersection of: macrophage
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0000479
subclass of: macrophage
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0000479
IAO_0000115: A macrophage constitutively resident in a particular tissue under non-inflammatory conditions, and capable of phagocytosing a variety of extracellular particulate material, including immune complexes, microorganisms, and dead cells.
database_cross_reference: FMA:84642
database_cross_reference: FMA:84644
has exact synonym: fixed macrophage
has exact synonym: resting histiocyte
has OBO namespace: cell
id: CL:0000864

central nervous system macrophage
type: Class
equivalent class: Class
  intersection of: tissue-resident macrophage
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0001017
subclass of: tissue-resident macrophage
subclass of: neural cell
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0001017
IAO_0000115: A tissue-resident macrophage found in the central nervous system.
has exact synonym: CNS macrophage
has OBO namespace: cell
id: CL:0000878

perivascular macrophage
type: Class
subclass of: central nervous system macrophage
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0001981
IAO_0000115: A central nervous system macrophage found in small blood vessels in the brain. Markers include CD14+CD16+CD163+.
has OBO namespace: cell
id: CL:0000881
comment: Markers: Human/monkey, mice: CD163. Human: CD14+CD16+CD163+.

thymocyte
type: Class
subclass of: immature T cell
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0002370
IAO_0000115: An immature T cell located in the thymus.
has broad synonym: immature T cell
has broad synonym: immature T lymphocyte
has broad synonym: immature T-cell
has broad synonym: immature T-lymphocyte
database_cross_reference: BTO:0001372
database_cross_reference: CALOHA:TS-1042
database_cross_reference: FMA:72202
database_cross_reference: XAO:0003159
has exact synonym: thymic lymphocyte
has OBO namespace: cell
id: CL:0000893

cytotoxic T cell
type: Class
equivalent class: Class
  intersection of: effector T cell
  intersection of: Restriction
    on property: capable of
    some values from: GO_0001913
subclass of: effector T cell
subclass of: Restriction
  on property: capable of
  some values from: GO_0001913
IAO_0000115: A mature T cell that differentiated and acquired cytotoxic function with the phenotype perforin-positive and granzyme-B positive.
database_cross_reference: BTO:0000289
database_cross_reference: CALOHA:TS-0190
database_cross_reference: FMA:70573
has exact synonym: cytotoxic T lymphocyte
has exact synonym: cytotoxic T-cell
has exact synonym: cytotoxic T-lymphocyte
has OBO namespace: cell
id: CL:0000910

effector T cell
type: Class
subclass of: mature T cell
IAO_0000115: A differentiated T cell with ability to traffic to peripheral tissues and is capable of mounting a specific immune response.
has exact synonym: effector T lymphocyte
has exact synonym: effector T-cell
has exact synonym: effector T-lymphocyte
has OBO namespace: cell
id: CL:0000911

helper T cell
type: Class
equivalent class: Class
  intersection of: effector T cell
  intersection of: Restriction
    on property: capable of
    some values from: GO_0001816
subclass of: effector T cell
subclass of: Restriction
  on property: capable of
  some values from: GO_0001816
IAO_0000115: A effector T cell that provides help in the form of secreted cytokines to other immune cells.
database_cross_reference: BTO:0002417
has exact synonym: T-helper cell
has exact synonym: helper T lymphocyte
has exact synonym: helper T-cell
has exact synonym: helper T-lymphocyte
has OBO namespace: cell
id: CL:0000912

lymphocyte of B lineage
type: Class
subclass of: lymphocyte
subclass of: Restriction
  on property: develops_from
  some values from: pro-B cell
IAO_0000115: A lymphocyte of B lineage is a lymphocyte that expresses CD19 on the cell surface. An additional defining characteristic is the commitment to express an immunoglobulin complex.
has OBO namespace: cell
id: CL:0000945
comment: Types of B lineage lymphocytes include B cells and antibody secreting cells (plasmablasts and plasma cells). Lymphocytes of B cell lineage can be distinguished from those of T cell lineage by their lack of CD3e (as part of the T cell receptor complex).

antibody secreting cell
type: Class
subclass of: lymphocyte of B lineage
IAO_0000115: A lymphocyte of B lineage that is devoted to secreting large amounts of immunoglobulin.
has OBO namespace: cell
id: CL:0000946

small pre-B-II cell
type: Class
subclass of: pre-B-II cell
subclass of: Restriction
  on property: has_part
  some values from: PR_000003457
subclass of: Restriction
  on property: has_part
  some values from: PR_000003460
IAO_0000115: A small pre-B-II cell is a pre-B-II cell that is Rag1-positive, Rag2-positive, pre-BCR-negative, and BCR-negative, is not proliferating, and carries a DNA rearrangement of one or more immunoglobulin light chain genes.
has exact synonym: small pre-BII cell
has OBO namespace: cell
id: CL:0000954
comment: Small pre-B-II cells are also reportedly CD10-positive, CD19-positive, CD34-negative, CD79a-positive, CD127-negative, TdT-negative, Vpre-B-negative, sIgM-negative, and sIgD-negative. Transcription factors: PU.1-positive, Ikaros-positive, E2A-positive, and PAX5-positive.

pre-B-II cell
type: Class
subclass of: precursor B cell
subclass of: Restriction
  on property: develops_from
  some values from: pro-B cell
IAO_0000115: A pre-B-II cell is a precursor B cell that expresses immunoglobulin mu heavy chain (IgHmu+), and lack expression of CD34, TdT, immunoglobulin kappa light chain and immunoglobulin lambda light chain.
database_cross_reference: BTO:0001133
database_cross_reference: CALOHA:TS-0819
has exact synonym: pre-B-lymphocyte
has exact synonym: pre-BII cell
has OBO namespace: cell
id: CL:0000955
comment: pre-B-II cell are also reportedly CD19-positive, CD22-positive, CD38-positive, CD45-positive, and CD48-positive.

plasmablast
type: Class
subclass of: mature B cell
subclass of: antibody secreting cell
subclass of: Restriction
  on property: develops_from
  some values from: mature B cell
IAO_0000115: An activated mature (naive or memory) B cell that is secreting immunoglobulin, typified by being CD27-positive, CD38-positive, CD138-negative.
database_cross_reference: FMA:84371
has OBO namespace: cell
id: CL:0000980
comment: This cell type is compatible with the HIPC Lyoplate markers for 'plasmablast'. Plasmablasts are also reportedly CD48-positive, CD63-positive, CD229-positive, CD270-positive, CD319-positive, CD352-positive, CD361-positive, and IgD-negative.

hematopoietic cell
type: Class
subclass of: animal cell
subclass of: somatic cell
IAO_0000115: A cell of a hematopoietic lineage.
database_cross_reference: BTO:0000574
database_cross_reference: CALOHA:TS-2017
database_cross_reference: FMA:70366
database_cross_reference: FMA:83598
has exact synonym: haematopoietic cell
has exact synonym: haemopoietic cell
has exact synonym: hemopoietic cell
has OBO namespace: cell
id: CL:0000988

conventional dendritic cell
type: Class
subclass of: dendritic cell
IAO_0000115: Conventional dendritic cell is a dendritic cell that is CD11c-high.
has broad synonym: interdigitating cell
has broad synonym: veiled cell
database_cross_reference: FMA:84191
has exact synonym: DC1
has exact synonym: cDC
has exact synonym: dendritic reticular cell
has exact synonym: type 1 DC
has OBO namespace: cell
id: CL:0000990
comment: Originally described in the dendritic cell ontology (DC_CL:0000003)(PMID:19243617) These cells are also CD20-negative, MHCII-positive.

CD34-positive, CD38-positive common myeloid progenitor OR CD34-positive, CD38-positive common lymphoid progenitor
type: Class
equivalent class: Class
  union of: CD34-positive, CD38-positive common lymphoid progenitor
  union of: CD34-positive, CD38-positive common myeloid progenitor
subclass of: hematopoietic oligopotent progenitor cell, lineage-negative
has broad synonym: CD71-positive common myeloid precursor OR CD7-negative lymphoid precursor OR CD7-positive lymphoid
has OBO namespace: cell
id: CL:0000995
comment: Originally described in the dendritic cell ontology (DC_CL:1100000)(PMID:19243617).

CD7-negative lymphoid progenitor OR granulocyte monocyte progenitor
type: Class
equivalent class: Class
  union of: granulocyte monocyte progenitor cell
  union of: CD7-negative lymphoid progenitor cell
subclass of: hematopoietic oligopotent progenitor cell, lineage-negative
has OBO namespace: cell
id: CL:0001012
comment: Originally described in the dendritic cell ontology (DC_CL:1110000)(PMID:19243617).

CD34-positive, CD38-positive common lymphoid progenitor
type: Class
subclass of: common lymphoid progenitor
subclass of: CD34-positive, CD38-positive common myeloid progenitor OR CD34-positive, CD38-positive common lymphoid progenitor
subclass of: Restriction
  on property: develops_from
  some values from: CD34-positive, CD38-negative multipotent progenitor cell
IAO_0000115: A common lymphoid progenitor that is CD10-positive, CD45RA-positive, CD34-positive and CD38-positive.
has exact synonym: CD10-positive common lymphocyte precursor
has exact synonym: CD10-positive common lymphocyte progenitor
has exact synonym: CD10-positive common lymphoid precursor
has OBO namespace: cell
id: CL:0001021
comment: These markers are associated with human common lymphoid progenitors. Originally described in the dendritic cell ontology (DC_CL:0000032)(PMID:19243617).

CD34-positive, CD38-negative hematopoietic stem cell
type: Class
subclass of: hematopoietic stem cell
IAO_0000115: CD133-positive hematopoietic stem cell is a hematopoietic stem cell that is CD34-positive, CD90-positive, and CD133-positive.
database_cross_reference: CALOHA:TS-0448
database_cross_reference: FMA:86475
has exact synonym: CD133-positive hematopoietic stem cell
has OBO namespace: cell
id: CL:0001024
comment: Cell markers are associated with human hematopoietic stem cells. Originally described in the dendritic cell ontology (DC_CL:0000035)(PMID:19243617).

CD34-positive, CD38-positive common myeloid progenitor
type: Class
subclass of: CD34-positive, CD38-positive common myeloid progenitor OR CD34-positive, CD38-positive common lymphoid progenitor
subclass of: common myeloid progenitor, CD34-positive
subclass of: Restriction
  on property: develops_from
  some values from: CD34-positive, CD38-negative multipotent progenitor cell
IAO_0000115: A common myeloid progenitor that is CD34-positive, CD38-positive, IL3ra-low, CD10-negative, CD7-negative, CD45RA-negative, and IL-5Ralpha-negative.
has narrow synonym: CD71-positive common myeloid precursor
has OBO namespace: cell
id: CL:0001026
comment: Markers are associated with human cell type. Originally described in the dendritic cell ontology (DC_CL:0000038)(PMID:19243617).

CD7-negative lymphoid progenitor cell
type: Class
subclass of: common lymphoid progenitor
subclass of: CD7-negative lymphoid progenitor OR granulocyte monocyte progenitor
subclass of: Restriction
  on property: develops_from
  some values from: CD34-positive, CD38-positive common lymphoid progenitor
IAO_0000115: CD7-negative lymphoid progenitor cell is a lymphoid progenitor cell that is CD34-positive, CD7-negative and CD45RA-negative.
has exact synonym: CD7-negative lymphoid precursor
has OBO namespace: cell
id: CL:0001027
comment: These markers are associated with human cells. Originally described in the dendritic cell ontology (DC_CL:0000039)(PMID:19243617).

cerebellar granule cell
type: Class
equivalent class: Class
  intersection of: granule cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0002037
subclass of: granule cell
subclass of: cerebellar neuron
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0002037
IAO_0000115: Granule cell that is part of the cerebellum.
database_cross_reference: BTO:0004278
has OBO namespace: cell
id: CL:0001031

cortical granule cell
type: Class
equivalent class: Class
  intersection of: granule cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0000956
subclass of: granule cell
subclass of: neuron of cerebral cortex
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0000956
IAO_0000115: Granule cell that is part of the cerebral cortex.
has OBO namespace: cell
id: CL:0001032

bone cell
type: Class
equivalent class: Class
  intersection of: animal cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0001474
subclass of: BFO_0000002
subclass of: animal cell
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0001474
IAO_0000115: A connective tissue cell found in bone.
created by: adiehl
creation date: 2011-11-16T04:28:16Z
has OBO namespace: cell
id: CL:0001035

common myeloid progenitor, CD34-positive
type: Class
subclass of: common myeloid progenitor
subclass of: precursor cell
subclass of: Restriction
  on property: has_part
  some values from: PR_000001944
subclass of: Restriction
  on property: has_part
  some values from: PR_000005307
subclass of: Restriction
  on property: has_part
  some values from: PR_000007857
subclass of: Restriction
  on property: has_part
  some values from: PR_000007858
subclass of: Restriction
  on property: capable of
  some values from: GO_0002573
subclass of: Restriction
  on property: capable of
  some values from: GO_0043011
IAO_0000115: A progenitor cell committed to myeloid lineage, including the megakaryocyte and erythroid lineages. These cells are CD34-positive, and express Gata1, Gata2, C/EBPa, and Pu.1.
has broad synonym: CMP
has exact synonym: common myeloid precursor, CD34-positive
has OBO namespace: cell
has related synonym: CFU-GEMM
has related synonym: CFU-S
has related synonym: colony forming unit granulocyte, erythrocyte, macrophage, and megakaryocyte
has related synonym: multipotential myeloid stem cell
has related synonym: myeloid stem cell
has related synonym: pluripotent stem cell (bone marrow)
id: CL:0001059
comment: CMP are reportedly CD16-positive, CD32-positive, CD38-positive, CD45RA-negative, CD110-negative, CD117-positive, CD123-positive, and SCA1-negative.

hematopoietic oligopotent progenitor cell, lineage-negative
type: Class
subclass of: hematopoietic oligopotent progenitor cell
subclass of: Restriction
  on property: develops_from
  some values from: hematopoietic multipotent progenitor cell
IAO_0000115: A hematopoietic oligopotent progenitor cell that has the ability to differentiate into limited cell types but lacks lineage cell markers and self renewal capabilities. Cell lacks hematopoeitic lineage markers.
created by: tmeehan
creation date: 2010-01-06T03:43:27Z
has OBO namespace: cell
id: CL:0001060

innate lymphoid cell
type: Class
subclass of: lymphocyte
subclass of: Restriction
  on property: capable of
  some values from: GO_0001816
subclass of: Restriction
  on property: capable of
  some values from: GO_0045087
IAO_0000115: A lymphocyte that lacks characteristic T cell, B cell, myeloid cell, and dendritic cell markers, that functions as part of the innate immune response to produce cytokines and other effector responses.
creator: http://orcid.org/0000-0001-9990-8331
date: 2017-01-30T20:20:48Z
has OBO namespace: cell
id: CL:0001065

group 1 innate lymphoid cell
type: Class
equivalent class: Class
  intersection of: innate lymphoid cell
  intersection of: Restriction
    on property: capable of
    some values from: GO_0032609
subclass of: innate lymphoid cell
subclass of: Restriction
  on property: capable of
  some values from: GO_0032609
IAO_0000115: An innate lymphoid cell that is capable of producing the type 1 cytokine IFN-gamma, but not Th2 or Th17 cell-associated cytokines.
creator: http://orcid.org/0000-0001-9990-8331
date: 2017-01-30T20:42:44Z
has OBO namespace: cell
id: CL:0001067

ILC1
type: Class
equivalent class: Class
  intersection of: group 1 innate lymphoid cell
  intersection of: Class
    complement of: Restriction
      on property: capable of
      some values from: GO_0001909
subclass of: group 1 innate lymphoid cell
IAO_0000115: A group 1 innate lymphoid cell that is non-cytotoxic.
creator: http://orcid.org/0000-0001-9990-8331
date: 2017-01-30T20:54:12Z
has OBO namespace: cell
id: CL:0001068

macrophage dendritic cell progenitor
type: Class
equivalent class: Class
  intersection of: hematopoietic oligopotent progenitor cell
  intersection of: Restriction
    on property: capable of
    some values from: GO_0030224
  intersection of: Restriction
    on property: capable of
    some values from: GO_0043011
subclass of: myeloid cell
subclass of: hematopoietic oligopotent progenitor cell
subclass of: precursor cell
subclass of: Restriction
  on property: develops_from
  some values from: granulocyte monocyte progenitor cell
subclass of: Restriction
  on property: capable of
  some values from: GO_0030224
subclass of: Restriction
  on property: capable of
  some values from: GO_0043011
IAO_0000115: A progenitor cell that can give rise to plasmacytoid and myeloid dendritic cells, and to monocytes and macrophages.
created by: tmeehan
creation date: 2010-01-19T02:51:58Z
has exact synonym: MDP
has OBO namespace: cell
id: CL:0002009

basophil mast progenitor cell
type: Class
subclass of: myeloid cell
subclass of: granulocytopoietic cell
subclass of: Restriction
  on property: has_part
  some values from: PR_000005307
subclass of: Restriction
  on property: has_part
  some values from: PR_000007857
subclass of: Restriction
  on property: has_part
  some values from: PR_000007858
subclass of: Restriction
  on property: develops_from
  some values from: granulocyte monocyte progenitor cell
subclass of: Restriction
  on property: capable of
  some values from: GO_0030221
subclass of: Restriction
  on property: capable of
  some values from: GO_0060374
IAO_0000115: A cell type that can give rise to basophil and mast cells. This cell is CD34-positive, CD117-positive, CD125-positive, FceRIa-negative, and T1/ST2-negative, and expresses Gata-1, Gata-2, C/EBPa
created by: tmeehan
creation date: 2010-04-27T12:46:33Z
has exact synonym: BMCP
has OBO namespace: cell
id: CL:0002028
comment: There may be an intermediate cell type. These cells also CD13-positive, CD16-positive, CD32-positive, and integrin beta 7-positive. Transcription factors: GATA1-positive, MCP-1-positive, mitf-positive, PU.1-positive, and CEBP/a-low.

hematopoietic lineage restricted progenitor cell
type: Class
subclass of: BFO_0000004
subclass of: hematopoietic precursor cell
subclass of: Restriction
  on property: develops_from
  some values from: hematopoietic oligopotent progenitor cell
disjoint with: hematopoietic oligopotent progenitor cell
IAO_0000115: A hematopoietic progenitor cell that is capable of developing into only one lineage of hematopoietic cells.
created by: tmeehan
creation date: 2010-01-06T03:43:20Z
has OBO namespace: cell
id: CL:0002031

hematopoietic oligopotent progenitor cell
type: Class
subclass of: BFO_0000004
subclass of: hematopoietic precursor cell
subclass of: Restriction
  on property: develops_from
  some values from: hematopoietic multipotent progenitor cell
IAO_0000115: A hematopoietic oligopotent progenitor cell that has the ability to differentiate into limited cell types but lacks lineage cell markers and self renewal capabilities. Cell lacks hematopoeitic lineage markers.
created by: tmeehan
creation date: 2010-01-06T03:43:27Z
has OBO namespace: cell
id: CL:0002032
comment: This cell type is intended to be compatible with any vertebrate hematopoietic oligopotent progenitor cell. For mammalian hematopoietic oligopotent progenitor cells known to be lineage-negative, please use the term 'hematopoietic oligopotent progenitor cell' (CL_0001060).

CD34-positive, CD38-negative multipotent progenitor cell
type: Class
subclass of: hematopoietic multipotent progenitor cell
subclass of: Restriction
  on property: develops_from
  some values from: CD34-positive, CD38-negative hematopoietic stem cell
IAO_0000115: A hematopoietic multipotent progenitor cell that is CD34-positive, CD38-negative, CD45RA-negative, and CD90-negative.
created by: tmeehan
creation date: 2010-01-12T11:14:15Z
has OBO namespace: cell
id: CL:0002043
comment: Cell markers are associated with human hematopoietic multipotent progenitor cells.

type I pneumocyte
type: Class
equivalent class: Class
  intersection of: pneumocyte
  intersection of: Restriction
    on property: capable of
    some values from: respiratory gaseous exchange
subclass of: material entity
subclass of: pneumocyte
subclass of: Restriction
  on property: capable of
  some values from: respiratory gaseous exchange
IAO_0000115: A type I pneumocyte is a flattened, branched pneumocyte that covers more than 98% of the alveolar surface. This large cell has thin (50-100 nm) cytoplasmic extensions to form the air-blood barrier essential for normal gas exchange.
created by: tmeehan
creation date: 2010-06-23T04:37:54Z
database_cross_reference: BTO:0000780
database_cross_reference: FMA:62500
has exact synonym: AT1
has exact synonym: ATI
has exact synonym: lung type 1 cells
has exact synonym: membranous pneumocytes
has exact synonym: pulmonary alveolar type I cell
has exact synonym: small alveolar cells
has exact synonym: squamous alveolar cell
has exact synonym: squamous alveolar lining cell
has exact synonym: type 1 alveolar epithelial cells
has exact synonym: type 1 pneumocyte
has exact synonym: type I alveolar cells
has exact synonym: type I alveolar epithelial cells
has OBO namespace: cell
id: CL:0002062

type II pneumocyte
type: Class
equivalent class: Class
  intersection of: pneumocyte
  intersection of: Restriction
    on property: capable of
    some values from: secretion by cell
  intersection of: Restriction
    on property: capable of
    some values from: GO_0043129
subclass of: surfactant secreting cell
subclass of: pneumocyte
subclass of: lung secretory cell
subclass of: Restriction
  on property: capable of
  some values from: secretion by cell
subclass of: Restriction
  on property: capable of
  some values from: GO_0043129
IAO_0000115: A type II pneumocyte is a pneumocyte that modulates the fluid surrounding the alveolar epithelium by secreting and recycling surfactants. This cell type also contributes to tissue repair and can differentiate after injury into a type I pneumocyte. Thicker than squamous alveolar cells, have a rounded apical surface that projects above the level of surrounding epithelium. The free surface is covered by short microvilli.
created by: tmeehan
creation date: 2010-06-24T12:04:13Z
database_cross_reference: BTO:0000538
database_cross_reference: FMA:62501
has exact synonym: AT2
has exact synonym: ATII
has exact synonym: TII
has exact synonym: cuboidal type II cell
has exact synonym: granular pneumocyte
has exact synonym: great alveolar cell
has exact synonym: lung type 2 cell
has exact synonym: type 2 alveolar epithelial cell
has exact synonym: type 2 alveolocyte
has exact synonym: type 2 pneumocyte
has exact synonym: type II alveolar cell
has exact synonym: type II alveolar epithelial cell
has exact synonym: type II alveolocyte
has OBO namespace: cell
has related synonym: lung type II cell
id: CL:0002063

pancreatic acinar cell
type: Class
equivalent class: Class
  intersection of: acinar cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0001263
subclass of: acinar cell
subclass of: pancreas exocrine glandular cell
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0001263
subclass of: Restriction
  on property: has_part
  some values from: GO_0042589
IAO_0000115: A secretory cell found in pancreatic acini that secretes digestive enzymes and mucins. This cell is a typical zymogenic cell, have a basal nucleus and basophilic cytoplasm consisting of regular arrays of granular endoplasmic reticulum with mitochondria and dense secretory granules.
created by: tmeehan
creation date: 2010-06-24T03:16:29Z
database_cross_reference: BTO:0000028
database_cross_reference: CALOHA:TS-0737
database_cross_reference: FMA:63032
has exact synonym: acinar cell of pancreas
has OBO namespace: cell
id: CL:0002064

type A enterocrine cell
type: Class
equivalent class: Class
  intersection of: enteroendocrine cell
  intersection of: Restriction
    on property: capable of
    some values from: GO_0070091
subclass of: enteroendocrine cell
subclass of: glucagon secreting cell
subclass of: Restriction
  on property: capable of
  some values from: GO_0070091
IAO_0000115: An enterocrine cell that produces glucagon.
created by: tmeehan
creation date: 2010-09-10T10:48:54Z
database_cross_reference: FMA:62939
has OBO namespace: cell
id: CL:0002067

Purkinje myocyte
type: Class
subclass of: specialized cardiac myocyte
IAO_0000115: Specialized cardiac myocyte that is subendocardially interspersed with the regular cardiac muscle cell. They are uninucleate cylindrical cells, associated end-to-end in long rows, continue from the node to the atrioventricular bundle; relatively short compared to ordinary myocytes but are nearly twice their diameter.
created by: tmeehan
creation date: 2010-06-28T08:36:15Z
database_cross_reference: BTO:0001032
database_cross_reference: FMA:14146
has exact synonym: Purkinje cell fiber
has exact synonym: Purkinje muscle cell
has exact synonym: myocytus conducens cardiacus
has OBO namespace: cell
id: CL:0002068

enterocyte of epithelium of large intestine
type: Class
equivalent class: Class
  intersection of: enterocyte
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0001278
subclass of: enterocyte
subclass of: epithelial cell of large intestine
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0001278
IAO_0000115: Columnar cell which populate the epithelium of large intestine and absorb water. This cell is the most numerous of the epithelial cell types in the large intestine; bear apical microvilli, contain secretory granules in their apical cytoplasm; secretion appears to be largely mucins, but is also rich in antibodies of the IgA type.
created by: tmeehan
creation date: 2010-06-29T11:07:25Z
has broad synonym: columnar cell
database_cross_reference: BTO:0002484
database_cross_reference: FMA:63638
database_cross_reference: FMA:66771
has exact synonym: columnar cell of the colon
has exact synonym: vacuolar absorptive cell
has OBO namespace: cell
id: CL:0002071

nodal myocyte
type: Class
subclass of: specialized cardiac myocyte
IAO_0000115: A specialized cardiac myocyte in the sinoatrial and atrioventricular nodes. The cell is slender and fusiform confined to the nodal center, circumferentially arranged around the nodal artery.
created by: tmeehan
creation date: 2010-06-29T11:41:37Z
has broad synonym: pacemaker cell
database_cross_reference: BTO:0004190
database_cross_reference: FMA:67101
has exact synonym: P cell
has exact synonym: cardiac pacemaker cell
has exact synonym: myocytus nodalis
has OBO namespace: cell
id: CL:0002072

transitional myocyte
type: Class
subclass of: specialized cardiac myocyte
IAO_0000115: Specialized cardiac myocyte which is in the internodal tract and atrioventricular node. The cell is more slender than ordinary atrial myocytes and has more myofibrils than nodal myocytes.
created by: tmeehan
creation date: 2010-06-29T02:39:32Z
database_cross_reference: FMA:67142
has OBO namespace: cell
id: CL:0002073

myocardial endocrine cell
type: Class
subclass of: endocrine cell
subclass of: specialized cardiac myocyte
IAO_0000115: The myoendocrine cellis a specialized myocyte localized mainly in the right and left atrial appendages, and also scattered within other areas of the atria and along the conductive system in the ventricular septum. The most conspicuous feature distinguishing myoendocrine cells from other atrial myoctyes is the presence of membane-bounded secretory granules (these granules contain precursor of cardiodilatins or atrial natriuretic polypeptides).
created by: tmeehan
creation date: 2010-06-29T11:50:47Z
database_cross_reference: FMA:67111
has OBO namespace: cell
id: CL:0002074

endo-epithelial cell
type: Class
subclass of: BFO_0000004
subclass of: epithelial cell
subclass of: somatic cell
subclass of: Restriction
  on property: develops_from
  some values from: endodermal cell
IAO_0000115: An epithelial cell derived from endoderm.
created by: tmeehan
creation date: 2010-06-29T03:38:14Z
database_cross_reference: FMA:69075
has OBO namespace: cell
id: CL:0002076

ecto-epithelial cell
type: Class
equivalent class: Class
  intersection of: epithelial cell
  intersection of: Restriction
    on property: develops_from
    some values from: ectodermal cell
subclass of: BFO_0000004
subclass of: epithelial cell
subclass of: somatic cell
subclass of: Restriction
  on property: develops_from
  some values from: ectodermal cell
IAO_0000115: An epithelial cell derived from ectoderm.
created by: tmeehan
creation date: 2010-06-29T03:38:22Z
database_cross_reference: FMA:69074
has OBO namespace: cell
id: CL:0002077

meso-epithelial cell
type: Class
equivalent class: Class
  intersection of: epithelial cell
  intersection of: Restriction
    on property: develops_from
    some values from: mesodermal cell
subclass of: BFO_0000004
subclass of: epithelial cell
subclass of: somatic cell
subclass of: Restriction
  on property: develops_from
  some values from: mesodermal cell
IAO_0000115: Epithelial cell derived from mesoderm or mesenchyme.
created by: tmeehan
creation date: 2010-06-29T03:49:14Z
database_cross_reference: FMA:69076
has exact synonym: epithelial mesenchymal cell
has OBO namespace: cell
id: CL:0002078

pancreatic ductal cell
type: Class
equivalent class: Class
  intersection of: epithelial cell of pancreas
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0001064
  intersection of: Restriction
    on property: capable of
    some values from: GO_0015106
subclass of: material entity
subclass of: branched duct epithelial cell
subclass of: epithelial cell of exocrine pancreas
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0001064
subclass of: Restriction
  on property: capable of
  some values from: GO_0015106
IAO_0000115: Epithelial cell found in the ducts of the pancreas. This cell type contributes to the high luminal pH.
created by: tmeehan
creation date: 2010-06-30T08:49:43Z
database_cross_reference: FMA:63099
has OBO namespace: cell
id: CL:0002079

pancreatic centro-acinar cell
type: Class
equivalent class: Class
  intersection of: epithelial cell of pancreas
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0001263
  intersection of: Restriction
    on property: capable of
    some values from: GO_0015106
subclass of: material entity
subclass of: epithelial cell of exocrine pancreas
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0001263
subclass of: Restriction
  on property: capable of
  some values from: GO_0015106
IAO_0000115: A cubodial epithelial cell that is continuous with the lining of intercalated ducts that drain the acinus. This cell type secretes a high pH solution to aid in activation of zymogens, and can differentiate into endocrine and exocrine pancreatic cell types.
created by: tmeehan
creation date: 2010-06-30T08:49:52Z
database_cross_reference: FMA:62455
has exact synonym: centroacinar cell of Langerhans
has exact synonym: pancreatic centroacinar cell
has OBO namespace: cell
id: CL:0002080

type II cell of adrenal medulla
type: Class
equivalent class: Class
  intersection of: adrenal medulla chromaffin cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0001236
  intersection of: Restriction
    on property: capable of
    some values from: GO_0048242
subclass of: adrenal medulla chromaffin cell
subclass of: epinephrine secreting cell
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0001236
subclass of: Restriction
  on property: capable of
  some values from: GO_0048242
IAO_0000115: A chromaffin cell of the adrenal medulla that produces epinephrine.
created by: tmeehan
creation date: 2010-07-14T09:41:42Z
database_cross_reference: FMA:69322
has exact synonym: adremergic chromaffin cell
has exact synonym: adrenal secreting cell of the adrenal medulla
has exact synonym: epiniphrine secreting cell of the adrenal medulla
has OBO namespace: cell
id: CL:0002082

type I cell of adrenal medulla
type: Class
equivalent class: Class
  intersection of: adrenal medulla chromaffin cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0001236
  intersection of: Restriction
    on property: capable of
    some values from: norepinephrine secretion
subclass of: adrenal medulla chromaffin cell
subclass of: noradrenergic cell
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0001236
subclass of: Restriction
  on property: capable of
  some values from: norepinephrine secretion
IAO_0000115: A chromaffin cell of the adrenal medulla that produces norepinephrine.
created by: tmeehan
creation date: 2010-07-14T10:12:24Z
database_cross_reference: FMA:69321
has exact synonym: noradrenergic chromaffin cell
has OBO namespace: cell
id: CL:0002083

specialized cardiac myocyte
type: Class
subclass of: cardiac muscle cell
IAO_0000115: A cardiac myocyte that is an excitable cells in the myocardium, specifically in the conducting system of heart.
created by: tmeehan
creation date: 2010-07-21T01:33:38Z
database_cross_reference: FMA:67968
has OBO namespace: cell
id: CL:0002086

nongranular leukocyte
type: Class
subclass of: leukocyte
IAO_0000115: A leukocyte that lacks granules.
created by: tmeehan
creation date: 2010-07-22T11:30:33Z
database_cross_reference: FMA:62855
has exact synonym: agranular leukocyte
has OBO namespace: cell
id: CL:0002087

interstitial cell of Cajal
type: Class
equivalent class: Class
  intersection of: neurecto-epithelial cell
  intersection of: Restriction
    on property: capable of
    some values from: GO_0043134
subclass of: material entity
subclass of: neurecto-epithelial cell
subclass of: Restriction
  on property: capable of
  some values from: GO_0043134
IAO_0000115: This is a cell found in the gastrointestinal tract of mammals and serves as a pacemaker that triggers gut contraction. ICCs mediate inputs from the enteric nervous system to smooth muscle cells and are thought to be the cells from which gastrointestinal stromal tumors (GISTs) arise.
created by: tmeehan
creation date: 2010-07-22T03:26:00Z
database_cross_reference: BTO:0003914
database_cross_reference: FMA:86573
has exact synonym: ICC
has exact synonym: intestinal pacemaker cell
has OBO namespace: cell
id: CL:0002088
comment: Some argue this cell type is of mesenchymal origin.

bone marrow cell
type: Class
equivalent class: Class
  intersection of: bone cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0002371
subclass of: BFO_0000004
subclass of: bone cell
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0002371
IAO_0000115: A cell found in the bone marrow. This can include fibroblasts, macrophages, adipocytes, osteoblasts, osteoclasts, endothelial cells and hematopoietic cells.
created by: tmeehan
creation date: 2010-07-22T04:48:15Z
database_cross_reference: BTO:0004850
database_cross_reference: FMA:83621
has OBO namespace: cell
id: CL:0002092
comment: MH consider whether bone marrow cells are bone cells in the structural sense vs. being part of bone organ sense.

hilus cell of ovary
type: Class
subclass of: androgen secreting cell
subclass of: stromal cell of ovary
IAO_0000115: A cell in the hilum of the ovary that produces androgens.
created by: tmeehan
creation date: 2010-08-23T11:18:18Z
database_cross_reference: FMA:18710
has exact synonym: hilar cell of ovary
has OBO namespace: cell
id: CL:0002095

cortical cell of adrenal gland
type: Class
equivalent class: Class
  intersection of: meso-epithelial cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0001235
subclass of: steroid hormone secreting cell
subclass of: meso-epithelial cell
subclass of: adrenal gland glandular cell
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0001235
IAO_0000115: A cell of the adrenal cortex. Cell types include those that synthesize and secrete chemical derivatives (steroids) of cholesterol.
created by: tmeehan
creation date: 2010-08-24T01:37:44Z
database_cross_reference: FMA:69545
has exact synonym: adrenal cortex cell
has exact synonym: adrenocortical cell
has OBO namespace: cell
id: CL:0002097

innate effector T cell
type: Class
equivalent class: Class
  intersection of: effector T cell
  intersection of: Restriction
    on property: capable of
    some values from: GO_0045087
subclass of: effector T cell
subclass of: Restriction
  on property: capable of
  some values from: GO_0045087
IAO_0000115: A T cell with a receptor of limited diversity that is capable of immediate effector functions upon stimulation.
created by: tmeehan
creation date: 2010-08-20T02:14:25Z
has OBO namespace: cell
id: CL:0002127

stromal cell of ovary
type: Class
equivalent class: Class
  intersection of: stromal cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0000992
subclass of: stromal cell
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0000992
IAO_0000115: A stomal cell of the ovary
created by: tmeehan
creation date: 2010-08-23T12:10:31Z
database_cross_reference: FMA:72299
has exact synonym: ovarian stromal cell
has OBO namespace: cell
id: CL:0002132

stromal cell of ovarian medulla
type: Class
equivalent class: Class
  intersection of: stromal cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0013192
subclass of: stromal cell of ovary
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0013192
IAO_0000115: A stromal cell of the ovarian medulla.
created by: tmeehan
creation date: 2010-08-23T12:12:17Z
database_cross_reference: FMA:256171
has OBO namespace: cell
id: CL:0002134

endothelial cell of lymphatic vessel
type: Class
equivalent class: Class
  intersection of: endothelial cell of vascular tree
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0001473
  intersection of: Restriction
    on property: develops_from
    some values from: vascular lymphangioblast
subclass of: endothelial cell of vascular tree
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0001473
subclass of: Restriction
  on property: develops_from
  some values from: vascular lymphangioblast
IAO_0000115: A endothelial cell of a lymphatic vessel. The border of the oak leaf-shaped endothelial cell of initial lymphatics are joined by specialized buttons. The discontinuous feature of buttons distinguishes them from zippers in collecting lymphatics, but both types of junctions are composed of proteins typical of adherens junctions and tight junctions found in the endothelium of blood vessels. Buttons seal the sides of flaps of the oak leaf-shaped endothelial cell, leaving open the tips of flaps as routes for fluid entry without disassembly and reformation of intercellular junctions.
created by: tmeehan
creation date: 2010-08-24T02:05:28Z
has alternative id: CL:1000421
database_cross_reference: BTO:0004167
database_cross_reference: FMA:68458
has exact synonym: LEC
has exact synonym: lymphatic endothelial cell
has OBO namespace: cell
id: CL:0002138

endothelial cell of vascular tree
type: Class
subclass of: endothelial cell
IAO_0000115: An endothelial cell of the vascular tree, which includes blood vessels and lymphatic vessels.
created by: tmeehan
creation date: 2010-08-24T02:06:40Z
database_cross_reference: BTO:0001854
database_cross_reference: CALOHA:TS-1106
database_cross_reference: FMA:67755
has exact synonym: vascular endothelial cell
has narrow synonym: cubodial endothelial cell of vascular tree
has OBO namespace: cell
id: CL:0002139
comment: These cells are reportedly CD31-positive, CD34-positive, CD144-positive, TAL1-positive.

acinar cell of sebaceous gland
type: Class
equivalent class: Class
  intersection of: sebum secreting cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0003487
subclass of: sebum secreting cell
subclass of: acinar cell
subclass of: epithelial cell of sweat gland
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0003487
IAO_0000115: A sebum secreting cell of the skin that secretes sebum into the hair follicles.
created by: tmeehan
creation date: 2010-08-24T09:27:52Z
has alternative id: CL:0002587
has broad synonym: sebocyte
database_cross_reference: BTO:0004613
database_cross_reference: FMA:70953
has OBO namespace: cell
id: CL:0002140

capillary endothelial cell
type: Class
equivalent class: Class
  intersection of: blood vessel endothelial cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0001915
subclass of: blood vessel endothelial cell
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0001915
IAO_0000115: An endothelial cell found in capillaries.
created by: tmeehan
creation date: 2010-08-24T10:15:00Z
database_cross_reference: BTO:0004956
database_cross_reference: CALOHA:TS-0112
database_cross_reference: FMA:67756
has OBO namespace: cell
id: CL:0002144

ciliated columnar cell of tracheobronchial tree
type: Class
subclass of: epithelial cell of tracheobronchial tree
subclass of: multi-ciliated epithelial cell
subclass of: Restriction
  on property: develops_from
  some values from: intermediate epitheliocyte
IAO_0000115: A ciliated columnar cell found in the trachea and bronchus. Vary from low to tall columnar; possesses up to 300 cilia at its surface, interspersed with long irregular microvilli with the cilia varying in length from about 6um in the trachea to about 4um in the terminal bronchioles; driving force of the ciliary current in the bronchial tree.
created by: tmeehan
creation date: 2010-08-24T03:38:29Z
database_cross_reference: FMA:70542
has OBO namespace: cell
id: CL:0002145

epithelial cell of uterus
type: Class
equivalent class: Class
  intersection of: endo-epithelial cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0000995
subclass of: endo-epithelial cell
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0000995
IAO_0000115: An epithelial cell of the uterus.
created by: tmeehan
creation date: 2010-08-24T10:45:54Z
has alternative id: CL:1000294
database_cross_reference: FMA:256161
has OBO namespace: cell
id: CL:0002149

general ecto-epithelial cell
type: Class
subclass of: ecto-epithelial cell
IAO_0000115: Epithelial cells derived from general body ectoderm and ectoderm placodes.
created by: tmeehan
creation date: 2010-08-26T08:31:08Z
database_cross_reference: FMA:70556
has OBO namespace: cell
id: CL:0002159

epithelial cell of Malassez
type: Class
subclass of: general ecto-epithelial cell
subclass of: epithelial cell of alimentary canal
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0011595
IAO_0000115: An epithelial cell that remains from the disintegration of the epithelial root sheath involved in the development of teeth.
created by: tmeehan
creation date: 2010-08-26T08:51:27Z
database_cross_reference: FMA:62987
has exact synonym: epithelial cell rests of Malassez
has exact synonym: epithelial debris of Malassez
has OBO namespace: cell
id: CL:0002166

olfactory epithelial cell
type: Class
equivalent class: Class
  intersection of: epithelial cell
  intersection of: Restriction
    on property: capable of
    some values from: GO_0050911
subclass of: sensory epithelial cell
subclass of: neurecto-epithelial cell
subclass of: Restriction
  on property: capable of
  some values from: GO_0050911
IAO_0000115: A specialized cell involved in sensory perception of smell.
created by: tmeehan
creation date: 2010-08-26T01:47:13Z
database_cross_reference: FMA:67870
has OBO namespace: cell
id: CL:0002167

basal cell of olfactory epithelium
type: Class
equivalent class: Class
  intersection of: olfactory epithelial cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0001997
subclass of: olfactory epithelial cell
subclass of: neural cell
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0001997
IAO_0000115: An epithelial cell located on the basal lamina of the olfactory epithelium.
created by: tmeehan
creation date: 2010-08-26T01:58:54Z
has alternative id: CL:1000395
has broad synonym: horizontal basal call
database_cross_reference: FMA:62303
has OBO namespace: cell
id: CL:0002169

keratinized cell of the oral mucosa
type: Class
equivalent class: Class
  intersection of: keratinizing barrier epithelial cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0003729
subclass of: keratinizing barrier epithelial cell
subclass of: epithelial cell of alimentary canal
subclass of: buccal mucosa cell
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0003729
IAO_0000115: A keratinized cell located in the hard palate or gingiva.
created by: tmeehan
creation date: 2010-08-26T02:51:30Z
has OBO namespace: cell
id: CL:0002170

folliculostellate cell of pars distalis of adenohypophysis
type: Class
equivalent class: Class
  intersection of: folliculostellate cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0006964
subclass of: folliculostellate cell
subclass of: neurecto-epithelial cell
subclass of: pituitary gland cell
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0006964
IAO_0000115: A supporting cell of the anterior pituitary gland involved in trophic and catabolic processes; expresses a broad spectrum of cytokeratins indicative of their epithelial nature.
created by: tmeehan
creation date: 2010-08-25T03:10:10Z
database_cross_reference: FMA:83102
has exact synonym: folliculostellate cell of pars anterior of adenohypophysis
has OBO namespace: cell
id: CL:0002177

epithelial cell of stomach
type: Class
equivalent class: Class
  intersection of: epithelial cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0000945
subclass of: epithelial cell of alimentary canal
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0000945
IAO_0000115: An epithelial cell found in the lining of the stomach.
created by: tmeehan
creation date: 2010-08-25T03:22:08Z
has alternative id: CL:1000399
database_cross_reference: FMA:62948
has OBO namespace: cell
id: CL:0002178

mucous cell of stomach
type: Class
equivalent class: Class
  intersection of: epithelial cell of stomach
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0001199
subclass of: glandular cell of stomach
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0001199
IAO_0000115: A mucous cell in the epithelium of the stomach.
created by: tmeehan
creation date: 2010-08-25T03:38:51Z
has alternative id: CL:1000404
database_cross_reference: FMA:63464
has OBO namespace: cell
id: CL:0002180

stem cell of gastric gland
type: Class
equivalent class: Class
  intersection of: multi fate stem cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0000325
subclass of: multi fate stem cell
subclass of: exocrine cell
subclass of: mucous cell of stomach
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0000325
IAO_0000115: A stomach epithelial cell that is olumnar in form with a few short apical microvilli; relatively undifferentiated mitotic cell from which other types of gland are derived; few in number, situated in the isthmus region of the gland and base of the gastric pit.
created by: tmeehan
creation date: 2010-08-25T03:57:08Z
has alternative id: CL:1000400
database_cross_reference: FMA:62953
has OBO namespace: cell
id: CL:0002183

basal cell of epidermis
type: Class
equivalent class: Class
  intersection of: basal cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0001003
subclass of: keratinocyte
subclass of: basal cell
subclass of: stem cell of epidermis
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0001003
IAO_0000115: A basally situated, mitotically active, columnar-shaped keratinocyte attached to the basement membrane.
created by: tmeehan
creation date: 2010-08-26T03:12:49Z
has alternative id: CL:1000439
database_cross_reference: FMA:70571
has OBO namespace: cell
id: CL:0002187

granulocytopoietic cell
type: Class
equivalent class: Class
  intersection of: myeloid lineage restricted progenitor cell
  intersection of: Restriction
    on property: capable of
    some values from: GO_0030851
subclass of: myeloid lineage restricted progenitor cell
subclass of: Restriction
  on property: capable of
  some values from: GO_0030851
IAO_0000115: A cell involved in the formation of a granulocyte.
created by: tmeehan
creation date: 2010-08-30T12:54:27Z
database_cross_reference: FMA:83519
has OBO namespace: cell
id: CL:0002191

monopoietic cell
type: Class
equivalent class: Class
  intersection of: myeloid lineage restricted progenitor cell
  intersection of: Restriction
    on property: capable of
    some values from: GO_0030224
subclass of: myeloid lineage restricted progenitor cell
subclass of: Restriction
  on property: capable of
  some values from: GO_0030224
IAO_0000115: A cell involved in the formation of a monocyte (monopoiesis).
created by: tmeehan
creation date: 2010-08-30T01:27:48Z
database_cross_reference: FMA:83552
has OBO namespace: cell
id: CL:0002194

hepatic stem cell
type: Class
equivalent class: Class
  intersection of: multi fate stem cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0002107
subclass of: multi fate stem cell
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0002107
IAO_0000115: A stem cell that can give rise to the cells of the liver.
created by: tmeehan
creation date: 2010-08-30T02:00:42Z
database_cross_reference: FMA:86577
has OBO namespace: cell
id: CL:0002195

oncocyte
type: Class
subclass of: endo-epithelial cell
IAO_0000115: A large epithelial cell with an extremely acidophilic and granular cytoplasm, containing vast numbers of mitochondria; such cells may undergo neoplastic transformation. From the Greek word onkos meaning swelling, this cell type is found in parathyroid, salivary and thyroid glands.
created by: tmeehan
creation date: 2010-09-02T11:26:49Z
database_cross_reference: FMA:67606
has exact synonym: oxyphil
has OBO namespace: cell
id: CL:0002198

oxyphil cell of parathyroid gland
type: Class
subclass of: oncocyte
subclass of: epithelial cell of parathyroid gland
IAO_0000115: An oncocyte located in the parathyroid gland.
created by: tmeehan
creation date: 2010-09-02T11:33:23Z
database_cross_reference: FMA:69084
has OBO namespace: cell
id: CL:0002199

oxyphil cell of thyroid
type: Class
equivalent class: Class
  intersection of: oncocyte
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0002046
subclass of: oncocyte
subclass of: epithelial cell of thyroid gland
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0002046
IAO_0000115: An oncocyte located in the thyroid.
created by: tmeehan
creation date: 2010-09-02T11:33:26Z
database_cross_reference: FMA:87169
has exact synonym: Askanazy cells
has exact synonym: Hurthle cells
has OBO namespace: cell
id: CL:0002200

epithelial cell of tracheobronchial tree
type: Class
equivalent class: Class
  intersection of: epithelial cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0007196
subclass of: epithelial cell of lower respiratory tract
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0007196
IAO_0000115: An epithelial cell of the tracheobronchial tree.
created by: tmeehan
creation date: 2010-09-02T02:09:14Z
has alternative id: CL:1000407
database_cross_reference: FMA:66816
has OBO namespace: cell
id: CL:0002202

intermediate epitheliocyte
type: Class
subclass of: epithelial cell of tracheobronchial tree
IAO_0000115: An epithelial cell present in the trachea and bronchi; columnar in shape; generally lack cilia; immature forms of ciliated or secretory cells which have been formed from stem cells.
created by: tmeehan
creation date: 2010-09-02T02:53:59Z
database_cross_reference: FMA:69060
has exact synonym: undifferentiated columnar cell of tracheobronchial tree
has OBO namespace: cell
id: CL:0002209

interstitial cell of pineal gland
type: Class
subclass of: neurecto-epithelial cell
IAO_0000115: A cell located between the pinealocytes.
created by: tmeehan
creation date: 2010-09-02T04:28:41Z
database_cross_reference: FMA:86575
has OBO namespace: cell
id: CL:0002220

vertebrate lens cell
type: Class
subclass of: BFO_0000004
subclass of: epithelial cell
subclass of: crystallin accumulating cell
subclass of: somatic cell
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0000965
IAO_0000115: A cell comprising the transparent, biconvex body separating the posterior chamber and vitreous body, and constituting part of the refracting mechanism of the mammalian eye.
created by: tmeehan
creation date: 2010-09-07T10:38:03Z
database_cross_reference: FMA:70950
has OBO namespace: cell
id: CL:0002222

lens epithelial cell
type: Class
equivalent class: Class
  intersection of: columnar/cuboidal epithelial cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0001803
subclass of: columnar/cuboidal epithelial cell
subclass of: vertebrate lens cell
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0001803
IAO_0000115: A cell of the cuboidal epithelium that covers the lens. The cells of the lens epithelium regulate most of the homeostatic functions of the lens. As ions, nutrients, and liquid enter the lens from the aqueous humor, Na+/K+ ATPase pumps in the lens epithelial cells pump ions out of the lens to maintain appropriate lens osmolarity and volume, with equatorially positioned lens epithelium cells contributing most to this current. The activity of the Na+/K+ ATPases keeps water and current flowing through the lens from the poles and exiting through the equatorial regions. The cells of the lens epithelium also serve as the progenitors for new lens fibers. It constantly lays down fibers in the embryo, fetus, infant, and adult, and continues to lay down fibers for lifelong growth.
created by: tmeehan
creation date: 2010-09-07T10:45:47Z
database_cross_reference: FMA:67559
has OBO namespace: cell
id: CL:0002224

epithelial cell of prostate
type: Class
equivalent class: Class
  intersection of: endo-epithelial cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0002367
subclass of: endo-epithelial cell
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0002367
IAO_0000115: An epithelial cell of the prostate.
created by: tmeehan
creation date: 2010-09-07T01:49:29Z
has alternative id: CL:1000295
has alternative id: CL:1000408
database_cross_reference: FMA:256163
database_cross_reference: FMA:66817
has exact synonym: prostate epithelial cell
has OBO namespace: cell
id: CL:0002231

epithelial cell of prostatic duct
type: Class
equivalent class: Class
  intersection of: non-branched duct epithelial cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0002485
subclass of: non-branched duct epithelial cell
subclass of: epithelial cell of prostate
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0002485
IAO_0000115: An epithelial cell of prostatic duct.
created by: tmeehan
creation date: 2010-09-07T01:55:51Z
has alternative id: CL:1000462
database_cross_reference: FMA:74224
has exact synonym: ductal epithelial cell of prostate
has OBO namespace: cell
id: CL:0002232

basal epithelial cell of prostatic duct
type: Class
equivalent class: Class
  intersection of: basal cell of prostate epithelium
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0002485
subclass of: duct epithelial cell
subclass of: basal cell of prostate epithelium
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0002485
IAO_0000115: A cell that constitutes the basal layer of epithelium in the prostatic duct.
created by: tmeehan
creation date: 2010-09-07T01:59:12Z
has alternative id: CL:1000463
database_cross_reference: FMA:74226
has OBO namespace: cell
id: CL:0002236

marrow fibroblast
type: Class
equivalent class: Class
  intersection of: fibroblast
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0002371
subclass of: fibroblast
subclass of: bone marrow cell
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0002371
IAO_0000115: A fibroblast in the bone marrow.
created by: tmeehan
creation date: 2010-09-07T02:25:18Z
database_cross_reference: FMA:84377
has OBO namespace: cell
id: CL:0002240

pulmonary interstitial fibroblast
type: Class
equivalent class: Class
  intersection of: fibroblast
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0001004
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0005169
subclass of: fibroblast
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0001004
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0005169
IAO_0000115: A fibroblasts found in interstitial spaces in the pulmonary tract. Greater numbers of these cells are found in idiopathic pulmonary fibrosis.
created by: tmeehan
creation date: 2010-09-07T02:29:38Z
database_cross_reference: FMA:84467
has exact synonym: pulmonary myofibroblast
has exact synonym: pulmonary septal cell
has OBO namespace: cell
id: CL:0002241

nucleate cell
type: Class
equivalent class: Class
  intersection of: native cell
  intersection of: Restriction
    on property: has_part
    some values from: nucleus
subclass of: native cell
subclass of: Restriction
  on property: has_part
  some values from: nucleus
IAO_0000115: A cell containing at least one nucleus.
created by: tmeehan
creation date: 2010-09-07T03:32:33Z
database_cross_reference: FMA:67513
has OBO namespace: cell
id: CL:0002242

smooth muscle cell of sphincter of pupil
type: Class
equivalent class: Class
  intersection of: smooth muscle cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0001607
subclass of: sphincter associated smooth muscle cell
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0001607
subclass of: Restriction
  on property: develops_from
  some values from: neurectodermal cell
IAO_0000115: A circular smooth muscle cell of the iris, innervated by the ciliary nerves (parasympathetic), and acting to contract the pupil. This muscle cell derives from neuroectoderm. This smooth muscle cell results from transformation of epithelial cells to smooth muscle cells.
created by: tmeehan
creation date: 2010-09-08T08:53:42Z
database_cross_reference: FMA:70611
has exact synonym: smooth muscle fiber of sphincter of pupil
has OBO namespace: cell
has related synonym: smooth muscle fibre of sphincter of pupil
id: CL:0002243

peripheral blood stem cell
type: Class
equivalent class: Class
  intersection of: hematopoietic stem cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0000178
subclass of: hematopoietic stem cell
subclass of: circulating cell
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0000178
IAO_0000115: A hematopoeitic stem cell found in the blood. Normally found in very limited numbers in the peripheral circulation (less than 0.1% of all nucleated cells).
created by: tmeehan
creation date: 2010-09-07T03:57:09Z
database_cross_reference: BTO:0002669
database_cross_reference: FMA:86711
has exact synonym: PBSC
has OBO namespace: cell
id: CL:0002246

pluripotent stem cell
type: Class
subclass of: somatic stem cell
IAO_0000115: A pluripotent stem cell has the ability to form cells from all three germ layers (ectoderm, mesoderm, and endoderm). However, unlike totipotent stem cells, they cell can not generate all the cells of the whole organism such as placenta.
created by: tmeehan
creation date: 2010-09-07T04:26:06Z
database_cross_reference: FMA:70570
has OBO namespace: cell
id: CL:0002248

epithelial cell of alimentary canal
type: Class
equivalent class: Class
  intersection of: epithelial cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0001555
subclass of: endo-epithelial cell
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0001555
IAO_0000115: An epithelial cell of the musculomembranous digestive tube extending from the mouth to the anus.
created by: tmeehan
creation date: 2010-09-08T09:26:53Z
has OBO namespace: cell
id: CL:0002251

epithelial cell of esophagus
type: Class
equivalent class: Class
  intersection of: epithelial cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0001043
subclass of: epithelial cell of alimentary canal
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0001043
IAO_0000115: An epithelial cell of the esophagus.
created by: tmeehan
creation date: 2010-09-08T09:28:20Z
has alternative id: CL:1000402
database_cross_reference: FMA:63071
has OBO namespace: cell
id: CL:0002252

epithelial cell of large intestine
type: Class
equivalent class: Class
  intersection of: intestinal epithelial cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0000059
subclass of: intestinal epithelial cell
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0000059
IAO_0000115: An epithelial cell of the large intestine.
created by: tmeehan
creation date: 2010-09-08T09:28:22Z
has alternative id: CL:1000292
database_cross_reference: BTO:0004297
database_cross_reference: FMA:256157
has OBO namespace: cell
has related synonym: epithelial cell of colon
id: CL:0002253

epithelial cell of small intestine
type: Class
equivalent class: Class
  intersection of: intestinal epithelial cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0002108
subclass of: intestinal epithelial cell
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0002108
IAO_0000115: An epithelial cell of the small intestine.
created by: tmeehan
creation date: 2010-09-08T09:41:46Z
has alternative id: CL:1000293
database_cross_reference: FMA:256159
has OBO namespace: cell
id: CL:0002254

stromal cell of endometrium
type: Class
equivalent class: Class
  intersection of: stromal cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0001295
subclass of: stromal cell
subclass of: epithelial cell of uterus
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0001295
IAO_0000115: An epithelial cell that regulates growth and differentiation of the overlying epithelium.
created by: tmeehan
creation date: 2010-09-08T09:50:04Z
database_cross_reference: CALOHA:TS-1266
database_cross_reference: FMA:86490
has OBO namespace: cell
id: CL:0002255

epithelial cell of thyroid gland
type: Class
equivalent class: Class
  intersection of: endo-epithelial cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0002046
subclass of: glandular epithelial cell
subclass of: endo-epithelial cell
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0002046
IAO_0000115: An epithelial cell of thyroid gland.
created by: tmeehan
creation date: 2010-09-08T01:46:51Z
has alternative id: CL:1000297
database_cross_reference: FMA:256167
has OBO namespace: cell
id: CL:0002257

thyroid follicular cell
type: Class
subclass of: epithelial cell of thyroid gland
IAO_0000115: A cell type that varies from squamous to columnar, depending on their activity with microvillus directed luminally. This cell produces and secretes thyroid hormones.
created by: tmeehan
creation date: 2010-09-08T01:50:08Z
database_cross_reference: BTO:0003736
database_cross_reference: CALOHA:TS-1285
database_cross_reference: FMA:68782
has exact synonym: follicular cell of thyroid gland
has exact synonym: principal cell of thyroid gland
has exact synonym: thyroid gland follicular cell
has OBO namespace: cell
id: CL:0002258

epithelial cell of parathyroid gland
type: Class
equivalent class: Class
  intersection of: endo-epithelial cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0001132
subclass of: endo-epithelial cell
subclass of: parathyroid glandular cell
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0001132
IAO_0000115: An epithelial cell of the parathyroid gland.
created by: tmeehan
creation date: 2010-09-08T02:29:38Z
has alternative id: CL:1000429
database_cross_reference: FMA:70547
has OBO namespace: cell
id: CL:0002260

endothelial cell of viscerocranial mucosa
type: Class
subclass of: endo-epithelial cell
IAO_0000115: An endothelial cell found in the mucosa associated with the facial skeleton.
created by: tmeehan
creation date: 2010-09-14T10:40:12Z
has alternative id: CL:1000446
database_cross_reference: FMA:70627
has OBO namespace: cell
id: CL:0002261

endothelial cell of sinusoid
type: Class
equivalent class: Class
  intersection of: endothelial cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0003909
subclass of: endothelial cell
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0003909
IAO_0000115: An endothelial cell that lines any of the venous cavities through which blood passes in various glands and organs such as the spleen and liver.
created by: tmeehan
creation date: 2010-09-14T10:57:26Z
has alternative id: CL:1000403
database_cross_reference: FMA:63134
has OBO namespace: cell
id: CL:0002262

type A cell of stomach
type: Class
equivalent class: Class
  intersection of: type A enterocrine cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0000945
subclass of: type A enterocrine cell
subclass of: glandular cell of stomach
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0000945
IAO_0000115: A type of enteroendocrine cell found in the stomach that secretes glucagon.
created by: tmeehan
creation date: 2010-09-10T10:54:42Z
database_cross_reference: FMA:83411
has OBO namespace: cell
id: CL:0002264

type D cell of colon
type: Class
equivalent class: Class
  intersection of: type D enteroendocrine cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0001155
subclass of: type D enteroendocrine cell
subclass of: intestinal enteroendocrine cell
subclass of: colon glandular cell
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0001155
IAO_0000115: A D cell located in the colon.
created by: tmeehan
creation date: 2010-09-10T11:37:35Z
database_cross_reference: FMA:268744
has OBO namespace: cell
id: CL:0002265

type D cell of small intestine
type: Class
equivalent class: Class
  intersection of: type D enteroendocrine cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0002108
subclass of: type D enteroendocrine cell
subclass of: intestinal enteroendocrine cell
subclass of: small intestine glandular cell
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0002108
IAO_0000115: A type D cell of the small intestine.
created by: tmeehan
creation date: 2010-09-10T01:34:22Z
database_cross_reference: FMA:268736
has OBO namespace: cell
id: CL:0002266

type D cell of stomach
type: Class
equivalent class: Class
  intersection of: type D enteroendocrine cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0000945
subclass of: type D enteroendocrine cell
subclass of: glandular cell of stomach
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0000945
IAO_0000115: A type D cell found in the stomach.
created by: tmeehan
creation date: 2010-09-10T01:36:03Z
database_cross_reference: FMA:83410
has OBO namespace: cell
id: CL:0002267

histamine secreting cell
type: Class
equivalent class: Class
  intersection of: secretory cell
  intersection of: Restriction
    on property: capable of
    some values from: GO_0001821
subclass of: biogenic amine secreting cell
subclass of: Restriction
  on property: capable of
  some values from: GO_0001821
IAO_0000115: A cell type that secretes histamine.
created by: tmeehan
creation date: 2010-09-10T03:04:42Z
has OBO namespace: cell
id: CL:0002274

pancreatic PP cell
type: Class
equivalent class: Class
  intersection of: PP cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0000006
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0001264
subclass of: epithelial cell of pancreas
subclass of: PP cell
subclass of: pancreatic endocrine cell
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0000006
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0001264
IAO_0000115: A PP cell located in the islets of the pancreas.
created by: tmeehan
creation date: 2010-09-10T03:30:31Z
database_cross_reference: BTO:0000805
database_cross_reference: FMA:70588
has exact synonym: PP cell of pancreatic islet
has exact synonym: PP-cell of pancreatic islet
has exact synonym: pancreatic polypeptide-secreting cell
has OBO namespace: cell
id: CL:0002275
comment: The term PP cell of pancreatic acinus was obsoleted due to a lack of evidence, making PP cell of pancreatic islets synonymous with pancreatic PP cell.

epithelial cell of thymus
type: Class
equivalent class: Class
  intersection of: endo-epithelial cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0002370
subclass of: endo-epithelial cell
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0002370
IAO_0000115: An epithelial cell of the thymus. Epithelial reticular cells are pleomorphic, stellate, non-phagocytic cells which seem to be supportive in function and are held together by desmosomes. They replace the fibroblastoid reticular cells found in other lymphoid organs. Other epithelial cells in the medulla have the ultrastructure of secretory cells. Although different epithelial cells throughout the thymus appear alike by light microscopy their ultrastructure and function varies.
created by: tmeehan
creation date: 2010-09-13T02:34:22Z
has alternative id: CL:1000459
database_cross_reference: CALOHA:TS-1040
database_cross_reference: FMA:72208
has exact synonym: epithelial cell of thymus gland
has exact synonym: epithelial reticular cell
has exact synonym: epithelial reticular cell of thymus
has exact synonym: thymic epithelial cell
has OBO namespace: cell
id: CL:0002293

type-1 epithelial cell of thymus
type: Class
subclass of: cortical thymic epithelial cell
IAO_0000115: An epithelial cell with a well defined Golgi apparatus that makes up the continuous layer of cells bordering the thymic tissue beneath the capsule.
created by: tmeehan
creation date: 2010-09-13T02:37:23Z
database_cross_reference: FMA:72209
has exact synonym: subcapsular thymic epithelial cell
has OBO namespace: cell
id: CL:0002294

epithelial cell of skin gland
type: Class
equivalent class: Class
  intersection of: epithelial cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0002419
subclass of: general ecto-epithelial cell
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0002419
IAO_0000115: An epithelial cell of a skin gland.
created by: tmeehan
creation date: 2010-09-14T12:00:07Z
database_cross_reference: FMA:70657
has exact synonym: epithelial cell of gland of skin
has OBO namespace: cell
id: CL:0002308

corticotroph
type: Class
subclass of: adrenocorticotropic hormone secreting cell
subclass of: basophil cell of pars distalis of adenohypophysis
IAO_0000115: A basophil chromphil cell of the anterior pitiutary gland that produce adrenocorticotropic hormone, melanocyte-stimulating hormone and lipotropin. This cell type is irregular in shape and has short dendritic processes which are inserted among other neighboring cells;
created by: tmeehan
creation date: 2010-09-14T02:08:23Z
database_cross_reference: BTO:0002509
database_cross_reference: FMA:83098
has OBO namespace: cell
id: CL:0002309

mammotroph
type: Class
subclass of: prolactin secreting cell
subclass of: acidophil cell of pars distalis of adenohypophysis
IAO_0000115: An acidophilic cell of the anterior pituitary that produces prolactin.
created by: tmeehan
creation date: 2010-09-14T02:30:57Z
database_cross_reference: FMA:83096
has exact synonym: epsilon-acidophil
has exact synonym: lactotrope
has exact synonym: lactotroph
has exact synonym: lactotropic cell
has exact synonym: mammotrope
has exact synonym: mammotrophic cell
has exact synonym: mammotropic cell
has OBO namespace: cell
id: CL:0002311

somatotroph
type: Class
subclass of: somatotropin secreting cell
subclass of: acidophil cell of pars distalis of adenohypophysis
IAO_0000115: An acidophilic cell of the anterior pituitary that produces growth hormone, somatotropin.
created by: tmeehan
creation date: 2010-09-14T02:33:09Z
database_cross_reference: FMA:83095
has exact synonym: somatotrope
has exact synonym: somatotropic cell
has exact synonym: somatrophic cell
has OBO namespace: cell
id: CL:0002312

endocrine-paracrine cell of prostate gland
type: Class
equivalent class: Class
  intersection of: general ecto-epithelial cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0002367
  intersection of: Restriction
    on property: capable of
    some values from: hormone secretion
subclass of: glandular epithelial cell
subclass of: general ecto-epithelial cell
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0002367
subclass of: Restriction
  on property: capable of
  some values from: hormone secretion
IAO_0000115: An ecto-epithelial cell of the prostate gland that secretes hormones.
created by: tmeehan
creation date: 2010-09-14T03:01:58Z
database_cross_reference: CALOHA:TS-1280
database_cross_reference: FMA:74390
database_cross_reference: FMA:86774
has exact synonym: glandular cell of prostate
has exact synonym: neuro-epithelial cell of prostate gland
has OBO namespace: cell
id: CL:0002313

neural cell
type: Class
equivalent class: Class
  intersection of: cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0001016
subclass of: BFO_0000004
subclass of: animal cell
subclass of: somatic cell
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0001016
IAO_0000115: A cell that is part of the nervous system.
created by: tmeehan
creation date: 2010-09-15T01:34:57Z
database_cross_reference: CALOHA:TS-2040
database_cross_reference: FMA:70333
has OBO namespace: cell
id: CL:0002319

connective tissue cell
type: Class
equivalent class: Class
  intersection of: somatic cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0002384
subclass of: BFO_0000002
subclass of: animal cell
subclass of: somatic cell
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0002384
IAO_0000115: A cell of the supporting or framework tissue of the body, arising chiefly from the embryonic mesoderm and including adipose tissue, cartilage, and bone.
created by: tmeehan
creation date: 2010-09-15T03:01:54Z
has alternative id: CL:1000406
database_cross_reference: CALOHA:TS-2096
database_cross_reference: FMA:63875
has OBO namespace: cell
id: CL:0002320

embryonic cell
type: Class
subclass of: animal cell
IAO_0000115: A cell of the embryo.
created by: tmeehan
creation date: 2010-09-15T03:39:21Z
database_cross_reference: CALOHA:TS-0263
database_cross_reference: FMA:82840
database_cross_reference: FMA:82841
database_cross_reference: WBbt:0007028
has OBO namespace: cell
id: CL:0002321

mammary alveolar cell
type: Class
equivalent class: Class
  intersection of: glandular epithelial cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0003214
subclass of: milk secreting cell
subclass of: general ecto-epithelial cell
subclass of: mammary gland glandular cell
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0003214
IAO_0000115: The milk-producing cell of the alveolar unit that emerges during pregnancy.
created by: tmeehan
creation date: 2010-09-20T01:30:57Z
has alternative id: CL:0002230
has alternative id: CL:1000476
database_cross_reference: FMA:74506
database_cross_reference: FMA:79866
has exact synonym: epithelial cell of lactiferous gland
has exact synonym: luminal cell of alveolus of lactiferous gland
has OBO namespace: cell
id: CL:0002325

mammary gland epithelial cell
type: Class
equivalent class: Class
  intersection of: epithelial cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0001911
subclass of: BFO_0000004
subclass of: epithelial cell
subclass of: somatic cell
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0001911
IAO_0000115: An epithelial cell of the mammary gland.
created by: tmeehan
creation date: 2010-09-20T01:49:37Z
database_cross_reference: BTO:0004300
has exact synonym: breast epithelial cell
has exact synonym: mammary epithelial cell
has OBO namespace: cell
id: CL:0002327

bronchial epithelial cell
type: Class
equivalent class: Class
  intersection of: epithelial cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0002185
subclass of: epithelial cell of tracheobronchial tree
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0002031
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0002185
IAO_0000115: An epithelial cell of the bronchus.
created by: tmeehan
creation date: 2010-09-20T02:00:00Z
database_cross_reference: BTO:0002922
has OBO namespace: cell
id: CL:0002328

ciliated cell of the bronchus
type: Class
equivalent class: Class
  intersection of: ciliated cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0002185
subclass of: ciliated columnar cell of tracheobronchial tree
subclass of: bronchial epithelial cell
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0002185
IAO_0000115: A ciliated cell of the bronchus.
created by: tmeehan
creation date: 2010-09-20T02:21:12Z
has OBO namespace: cell
id: CL:0002332

neural crest derived fat cell
type: Class
equivalent class: Class
  intersection of: fat cell
  intersection of: Restriction
    on property: develops_from
    some values from: migratory neural crest cell
subclass of: fat cell
subclass of: Restriction
  on property: develops_from
  some values from: fibroblast neural crest derived
subclass of: Restriction
  on property: develops_from
  some values from: migratory neural crest cell
IAO_0000115: A fat cell derived from a neural crest cell.
created by: tmeehan
creation date: 2010-09-20T02:25:25Z
has OBO namespace: cell
id: CL:0002333

buccal mucosa cell
type: Class
subclass of: endothelial cell of viscerocranial mucosa
IAO_0000115: An endothelial cell that lines the oral cavitiy including the mucosa of the gums, the palate, the lip, and the cheek.
created by: tmeehan
creation date: 2010-09-20T02:52:54Z
has OBO namespace: cell
id: CL:0002336

prostate stem cell
type: Class
equivalent class: Class
  intersection of: stem cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0002367
subclass of: multi fate stem cell
subclass of: basal cell of prostate epithelium
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0002367
IAO_0000115: A prostate epithelial cell that is CD133-positive, CD44-positive, integrin A2beta3-high. This cell is a stem cell for the prostate epithelium.
created by: tmeehan
creation date: 2010-09-20T03:21:06Z
has exact synonym: CD133-positive prostate epithelial cell
has OBO namespace: cell
id: CL:0002339

basal cell of prostate epithelium
type: Class
subclass of: epithelial cell of prostate
IAO_0000115: An undifferentiated cell of the prostate epithelium that lacks secretory activity.
created by: tmeehan
creation date: 2010-09-20T03:34:10Z
has OBO namespace: cell
id: CL:0002341

endocardial cell
type: Class
equivalent class: Class
  intersection of: endothelial cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0002165
subclass of: cardiac endothelial cell
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0002165
IAO_0000115: An endothelial cell that lines the intracavitary lumen of the heart, separating the circulating blood from the underlying myocardium. This cell type releases a number of vasoactive substances including prostacyclin, nitrous oxide and endothelin.
created by: tmeehan
creation date: 2010-09-21T04:33:05Z
has alternative id: CL:1000475
database_cross_reference: FMA:75621
has exact synonym: endocardial endothelial cell
has exact synonym: endothelial cell of endocardium
has OBO namespace: cell
id: CL:0002350

progenitor cell of endocrine pancreas
type: Class
subclass of: multi fate stem cell
IAO_0000115: A multi-fate stem cell that is able to differentiate into the pancreas alpha, beta and delta endocrine cells. This cell type expresses neurogenin-3 and Isl-1.
created by: tmeehan
creation date: 2010-09-21T04:41:06Z
has exact synonym: pancreatic endocrine progenitor
has exact synonym: pancreatic islet progenitor cell
has OBO namespace: cell
id: CL:0002351

gestational hematopoietic stem cell
type: Class
equivalent class: Class
  intersection of: hematopoietic stem cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0000922
subclass of: hematopoietic stem cell
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0000922
IAO_0000115: A hematopoietic stem cell that exists during embryogenesis.
created by: tmeehan
creation date: 2010-09-22T09:05:13Z
has OBO namespace: cell
id: CL:0002352

placental hematopoietic stem cell
type: Class
equivalent class: Class
  intersection of: hematopoietic stem cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0001987
subclass of: extraembryonic cell
subclass of: gestational hematopoietic stem cell
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0001987
IAO_0000115: A hematopoietic stem cell of the placenta. This cell type is first observed E10.5 This cell type may give rise to fetal liver hematopoietic stem cells.
created by: tmeehan
creation date: 2010-09-22T10:30:02Z
has OBO namespace: cell
id: CL:0002359

keratocyte
type: Class
equivalent class: Class
  intersection of: fibroblast
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0001777
subclass of: fibroblast neural crest derived
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0001777
subclass of: Restriction
  on property: develops_from
  some values from: migratory cranial neural crest cell
IAO_0000115: A keratocyte is a specialized fibroblast residing in the cornea stroma that has a flattened, dendritic cell located between the lamellae with a large flattened nucleus and lengthy processes which communicate with neighboring cells. This corneal layer, representing about 85-90% of corneal thickness, is built up from highly regular collagenous lamellae and extracellular matrix components. Keratocytes play the major role in keeping it transparent, healing its wounds, and synthesizing its components. This cell type secretes collagen I, V, VI, and keratin sulfate.
created by: tmeehan
creation date: 2010-09-22T01:57:40Z
has exact synonym: corneal fibroblast
has exact synonym: corneal keratocyte
has OBO namespace: cell
id: CL:0002363

cortical thymic epithelial cell
type: Class
equivalent class: Class
  intersection of: epithelial cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0002123
subclass of: epithelial cell of thymus
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0002123
IAO_0000115: An epithelial cell of the cortical portion of the thymus. Epithelial cells in this region are required for positive selection of CD8-positive T cells.
created by: tmeehan
creation date: 2010-09-23T03:17:12Z
database_cross_reference: BTO:0004562
has exact synonym: cTEC
has OBO namespace: cell
id: CL:0002364

medullary thymic epithelial cell
type: Class
equivalent class: Class
  intersection of: epithelial cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0002124
subclass of: epithelial cell of thymus
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0002124
IAO_0000115: An epithelial cell of the medullary thymus. This cell type expresses a diverse range of tissue-specific antigens. This promiscuous gene expression is a cell-autonomous property of medullary epithelial cells and is maintained during the entire period of thymic T cell output.
created by: tmeehan
creation date: 2010-09-23T03:17:14Z
database_cross_reference: BTO:0004563
has exact synonym: mTEC
has OBO namespace: cell
id: CL:0002365

myometrial cell
type: Class
equivalent class: Class
  intersection of: smooth muscle cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0001296
subclass of: uterine smooth muscle cell
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0001296
IAO_0000115: A smooth muscle cell of the myometrium that enlarges and stretches during pregnancy, and contracts in response to oxytocin.
created by: tmeehan
creation date: 2010-09-23T03:46:34Z
database_cross_reference: BTO:0004519
has exact synonym: myometrium smooth muscle cell
has OBO namespace: cell
id: CL:0002366

respiratory epithelial cell
type: Class
equivalent class: Class
  intersection of: endo-epithelial cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0000065
subclass of: endo-epithelial cell
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0000065
IAO_0000115: An endo-epithelial cell of the respiratory tract.
created by: tmeehan
creation date: 2010-09-23T04:38:49Z
database_cross_reference: BTO:0004533
has exact synonym: airway epithelial cell
has OBO namespace: cell
id: CL:0002368

somatic cell
type: Class
subclass of: native cell
IAO_0000115: A cell of an organism that does not pass on its genetic material to the organism's offspring (i.e. a non-germ line cell).
created by: tmeehan
creation date: 2010-09-24T09:44:42Z
database_cross_reference: BTO:0001268
database_cross_reference: FMA:72300
database_cross_reference: WBbt:0008378
has OBO namespace: cell
id: CL:0002371
in subset: upper level

myotube
type: Class
subclass of: multinucleate cell
subclass of: striated muscle cell
subclass of: Restriction
  on property: has_part
  some values from: GO_0030017
IAO_0000115: A transversely striated, synctial muscle cell, formed by the fusion of myoblasts.
created by: tmeehan
creation date: 2010-09-24T01:13:01Z
has alternative id: CL:0000369
has exact synonym: myotubule
has exact synonym: single cell sarcomere
has OBO namespace: cell
id: CL:0002372

meningothelial cell
type: Class
subclass of: neurecto-epithelial cell
IAO_0000115: A neurecto-epithelial cell found in the arachnoid villi of dura mater. This cell type facilitates flow of cerebrospinal fluid into the blood.
created by: tmeehan
creation date: 2010-09-28T02:23:46Z
database_cross_reference: FMA:86588
has exact synonym: arachnoid cap cell
has OBO namespace: cell
id: CL:0002379

mature T cell
type: Class
subclass of: T cell
IAO_0000115: A T cell that expresses a T cell receptor complex and has completed T cell selection.
created by: tmeehan
creation date: 2010-10-12T01:56:15Z
has exact synonym: CD3e-positive T cell
has exact synonym: mature T-cell
has OBO namespace: cell
has related synonym: CD3epsilon T cell
id: CL:0002419

immature T cell
type: Class
subclass of: T cell
IAO_0000115: A T cell that has not completed T cell selection.
created by: tmeehan
creation date: 2010-10-12T01:56:17Z
database_cross_reference: BTO:0001372
database_cross_reference: CALOHA:TS-1042
has exact synonym: immature T-cell
has OBO namespace: cell
id: CL:0002420

nucleated reticulocyte
type: Class
equivalent class: Class
  intersection of: reticulocyte
  intersection of: Restriction
    on property: has_part
    some values from: nucleus
subclass of: reticulocyte
subclass of: nucleate cell
subclass of: Restriction
  on property: has_part
  some values from: nucleus
IAO_0000115: A reticulocyte that retains the nucleus and other organelles. Found in birds, fish, amphibians and reptiles.
created by: tmeehan
creation date: 2010-10-15T09:24:05Z
has OBO namespace: cell
id: CL:0002421

oligodendrocyte precursor cell
type: Class
equivalent class: Class
  intersection of: neuron associated cell (sensu Vertebrata)
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0001017
subclass of: neuron associated cell (sensu Vertebrata)
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0001017
subclass of: Restriction
  on property: develops_from
  some values from: glioblast (sensu Vertebrata)
IAO_0000115: The cell type from which oligodendrocytes develop. This cell originates from multiple structures within the developing brain including the medial ganglion eminence and the lateral ganglionic eminence. These cells migrate throughout the central nervous system and persist into adulthood where they play an important role in remyelination of injured neurons.
created by: tmeehan
creation date: 2010-11-10T02:51:34Z
has OBO namespace: cell
id: CL:0002453

peritubular myoid cell
type: Class
equivalent class: Class
  intersection of: myoepithelial cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0001343
subclass of: myoepithelial cell
subclass of: seminiferous tubule epithelial cell
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0001343
IAO_0000115: The flattened smooth myoepithelial cells of mesodermal origin that lie just outside the basal lamina of the seminiferous tubule.
created by: tmeehan
creation date: 2010-12-03T03:11:48Z
has OBO namespace: cell
id: CL:0002481

dermal melanocyte
type: Class
equivalent class: Class
  intersection of: melanocyte
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0002067
subclass of: melanocyte of skin
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0002067
IAO_0000115: A melanocyte that produces pigment in the dermis.
created by: tmeehan
creation date: 2010-12-03T03:17:05Z
has OBO namespace: cell
id: CL:0002482

hair follicle melanocyte
type: Class
equivalent class: Class
  intersection of: melanocyte
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0002073
subclass of: hair follicle cell
subclass of: epidermal melanocyte
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0002073
IAO_0000115: A melanocyte that produces pigment within the hair follicle.
created by: tmeehan
creation date: 2010-12-03T03:17:09Z
has OBO namespace: cell
id: CL:0002483

epithelial melanocyte
type: Class
equivalent class: Class
  intersection of: melanocyte
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0000483
subclass of: melanocyte
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0000483
IAO_0000115: A melanocyte that produces pigment in the epithelium.
created by: tmeehan
creation date: 2010-12-03T03:17:14Z
has OBO namespace: cell
id: CL:0002484
comment: The text defintion reference to the MP term appears to reference an epidermal melanocyte term. This term represents any melanocyte in any epithelium.

retinal melanocyte
type: Class
equivalent class: Class
  intersection of: melanocyte
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0000966
subclass of: melanocyte
subclass of: retinal cell
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0000966
IAO_0000115: A melanocyte of the retina. This cell type is distinct from pigmented retinal epithelium.
created by: tmeehan
creation date: 2010-12-03T03:25:32Z
has OBO namespace: cell
id: CL:0002485

auditory epithelial cell
type: Class
equivalent class: Class
  intersection of: epithelial cell
  intersection of: Restriction
    on property: capable of
    some values from: GO_0050910
subclass of: sensory epithelial cell
subclass of: Restriction
  on property: capable of
  some values from: GO_0050910
IAO_0000115: A specialized cell involved in auditory sensory perception.
created by: tmeehan
creation date: 2010-12-06T03:18:43Z
has OBO namespace: cell
id: CL:0002491

cardiocyte
type: Class
equivalent class: Class
  intersection of: somatic cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0007100
subclass of: BFO_0000002
subclass of: animal cell
subclass of: somatic cell
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0007100
IAO_0000115: A cell located in the heart, including both muscle and non muscle cells.
created by: tmeehan
creation date: 2010-12-07T09:37:22Z
database_cross_reference: BTO:0001539
database_cross_reference: CALOHA:TS-0115
database_cross_reference: FMA:83808
database_cross_reference: FMA:84791
has exact synonym: heart cell
has OBO namespace: cell
id: CL:0002494
comment: From Onard of the FMA: Cardiac muscle cell or cardiac myocyte is a striated muscle cell. Cardiocyte on the other hand is any cell in the heart which includes cells other than muscle cells (e.g. endothelial cell of endocardium). Unless there is a consensus among anatomists that cardiocytes refer only to muscle cells, we will treat them as a general class of cells in the heart.

adventitial cell
type: Class
equivalent class: Class
  intersection of: connective tissue cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0005742
subclass of: supportive cell
subclass of: connective tissue cell
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0005742
IAO_0000115: A cell of the adventitial layer of ductal structures such as the uterer, defent duct, biliary duct, etc
created by: tmeehan
creation date: 2010-12-07T04:03:56Z
database_cross_reference: BTO:0002441
database_cross_reference: FMA:84639
has OBO namespace: cell
id: CL:0002503

enteric smooth muscle cell
type: Class
equivalent class: Class
  intersection of: smooth muscle cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0000160
subclass of: smooth muscle cell
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0000160
IAO_0000115: A smooth muscle cell of the intestine.
created by: tmeehan
creation date: 2011-01-17T03:39:38Z
has exact synonym: intestinal smooth muscle cell
has OBO namespace: cell
id: CL:0002504

kidney epithelial cell
type: Class
equivalent class: Class
  intersection of: epithelial cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0002113
subclass of: epithelial cell
subclass of: kidney cell
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0002113
IAO_0000115: An epithelial cell of the kidney.
created by: tmeehan
creation date: 2011-02-08T10:46:34Z
database_cross_reference: KUPO:0001019
has OBO namespace: cell
id: CL:0002518

subcutaneous fat cell
type: Class
equivalent class: Class
  intersection of: fat cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0002190
subclass of: fat cell
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0002190
IAO_0000115: A fat cell that is part of subcutaneous adipose tissue.
created by: tmeehan
creation date: 2011-02-21T02:51:22Z
has exact synonym: subcutaneous adipocyte
has OBO namespace: cell
id: CL:0002521

epithelial cell of cervix
type: Class
equivalent class: Class
  intersection of: epithelial cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0000002
subclass of: BFO_0000004
subclass of: epithelial cell
subclass of: somatic cell
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0000002
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0004801
IAO_0000115: An epithelial cell of the cervix.
created by: tmeehan
creation date: 2011-02-24T08:20:08Z
has exact synonym: cervical canal epithelial cell
has exact synonym: cervical canal of uterus epithelial cell
has exact synonym: cervix epithelial cell
has exact synonym: cervix of uterus epithelial cell
has exact synonym: epithelial cell of cervical canal
has exact synonym: epithelial cell of cervical canal of uterus
has exact synonym: epithelial cell of cervix of uterus
has exact synonym: epithelial cell of neck of uterus
has exact synonym: epithelial cell of uterine cervix
has exact synonym: neck of uterus epithelial cell
has exact synonym: uterine cervix epithelial cell
has OBO namespace: cell
id: CL:0002535

intrahepatic bile duct epithelial cell
type: Class
equivalent class: Class
  intersection of: branched duct epithelial cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0004823
subclass of: BFO_0000004
subclass of: branched duct epithelial cell
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0004823
IAO_0000115: An epithelial cell of the intrahepatic portion of the bile duct.
created by: tmeehan
creation date: 2011-02-28T01:20:20Z
has OBO namespace: cell
id: CL:0002538

aortic smooth muscle cell
type: Class
equivalent class: Class
  intersection of: vascular associated smooth muscle cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0004178
subclass of: vascular associated smooth muscle cell
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0004178
IAO_0000115: A smooth muscle cell of the aorta.
created by: tmeehan
creation date: 2011-02-28T01:42:12Z
database_cross_reference: BTO:0004577
has OBO namespace: cell
id: CL:0002539

mesenchymal stem cell of the bone marrow
type: Class
equivalent class: Class
  intersection of: mesenchymal stem cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0002371
subclass of: mesenchymal stem cell
subclass of: bone marrow cell
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0002371
IAO_0000115: A mesenchymal stem cell that is part of the bone marrow.
created by: tmeehan
creation date: 2011-02-28T01:47:47Z
has OBO namespace: cell
id: CL:0002540

chorionic membrane mesenchymal stem cell
type: Class
equivalent class: Class
  intersection of: mesenchymal stem cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0003124
subclass of: mesenchymal stem cell
subclass of: extraembryonic cell
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0003124
IAO_0000115: A mesenchymal stem cell of the chorionic membrane.
created by: tmeehan
creation date: 2011-02-28T03:04:35Z
has OBO namespace: cell
id: CL:0002541

vein endothelial cell
type: Class
equivalent class: Class
  intersection of: blood vessel endothelial cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0001638
subclass of: blood vessel endothelial cell
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0001638
IAO_0000115: An endothelial cell that is part of the vein.
created by: tmeehan
creation date: 2011-02-28T03:48:11Z
has alternative id: CL:1000393
database_cross_reference: FMA:62104
database_cross_reference: KUPO:0001099
has exact synonym: endothelial cell of vein
has exact synonym: venous endothelial cell
has OBO namespace: cell
id: CL:0002543

embryonic blood vessel endothelial progenitor cell
type: Class
subclass of: mesodermal cell
subclass of: somatic cell
IAO_0000115: An endothelial progenitor cell that participates in angiogenesis during development.
created by: tmeehan
creation date: 2011-02-28T04:20:39Z
has OBO namespace: cell
id: CL:0002546
comment: See CL:0002619.

fibroblast of the aortic adventitia
type: Class
equivalent class: Class
  intersection of: fibroblast of tunica adventitia of artery
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0004664
subclass of: fibroblast of tunica adventitia of artery
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0004664
IAO_0000115: A fibroblast of the aortic adventitia.
created by: tmeehan
creation date: 2011-02-28T04:43:41Z
has OBO namespace: cell
id: CL:0002547

fibroblast of cardiac tissue
type: Class
equivalent class: Class
  intersection of: fibroblast
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0000948
subclass of: fibroblast
subclass of: cardiocyte
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0000948
IAO_0000115: A fibroblast that is part of the heart.
created by: tmeehan
creation date: 2011-02-28T04:57:44Z
has exact synonym: cardiac fibroblast
has OBO namespace: cell
id: CL:0002548

fibroblast of choroid plexus
type: Class
equivalent class: Class
  intersection of: fibroblast
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0001886
subclass of: fibroblast
subclass of: neural cell
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0001886
IAO_0000115: A fibroblast that is part of the choroid plexus.
created by: tmeehan
creation date: 2011-02-28T05:01:39Z
has OBO namespace: cell
id: CL:0002549

fibroblast of the conjunctiva
type: Class
equivalent class: Class
  intersection of: fibroblast
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0001811
subclass of: fibroblast
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0001811
IAO_0000115: A fibroblast that is part of the conjuctiva of the eye.
created by: tmeehan
creation date: 2011-02-28T05:03:44Z
has OBO namespace: cell
id: CL:0002550

fibroblast of dermis
type: Class
equivalent class: Class
  intersection of: skin fibroblast
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0002067
subclass of: skin fibroblast
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0002067
created by: tmeehan
creation date: 2011-02-28T05:05:33Z
has OBO namespace: cell
id: CL:0002551

fibroblast of gingiva
type: Class
equivalent class: Class
  intersection of: fibroblast
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0001828
subclass of: fibroblast
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0001828
created by: tmeehan
creation date: 2011-02-28T05:09:12Z
has OBO namespace: cell
id: CL:0002552

fibroblast of lung
type: Class
equivalent class: Class
  intersection of: fibroblast
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0002048
subclass of: fibroblast
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0002048
IAO_0000115: A fibroblast that is part of lung.
created by: tmeehan
creation date: 2011-02-28T05:11:03Z
database_cross_reference: BTO:0000764
database_cross_reference: CALOHA:TS-0575
has OBO namespace: cell
id: CL:0002553

fibroblast of lymphatic vessel
type: Class
equivalent class: Class
  intersection of: fibroblast
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0001473
subclass of: fibroblast
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0001473
IAO_0000115: A fibroblast of the lymphatic system.
created by: tmeehan
creation date: 2011-02-28T05:16:18Z
has OBO namespace: cell
id: CL:0002554

fibroblast of mammary gland
type: Class
equivalent class: Class
  intersection of: fibroblast
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0001911
subclass of: fibroblast
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0001911
IAO_0000115: A fibroblast that is part of the mammary gland.
created by: tmeehan
creation date: 2011-02-28T05:18:38Z
has OBO namespace: cell
id: CL:0002555

fibroblast of periodontium
type: Class
equivalent class: Class
  intersection of: fibroblast
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0001758
subclass of: fibroblast
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0001758
IAO_0000115: A fibroblast of the periodontium.
created by: tmeehan
creation date: 2011-02-28T05:19:48Z
has OBO namespace: cell
id: CL:0002556

fibroblast of pulmonary artery
type: Class
equivalent class: Class
  intersection of: fibroblast
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0002012
subclass of: fibroblast
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0002012
IAO_0000115: A fibroblast of pulmonary artery.
created by: tmeehan
creation date: 2011-02-28T05:22:27Z
has OBO namespace: cell
id: CL:0002557

hair follicle cell
type: Class
equivalent class: Class
  intersection of: somatic cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0002073
subclass of: BFO_0000004
subclass of: somatic cell
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0002073
IAO_0000115: An animal cell that is part of a hair follicle.
created by: tmeehan
creation date: 2011-03-01T04:11:01Z
has OBO namespace: cell
id: CL:0002559

outer root sheath cell
type: Class
equivalent class: Class
  intersection of: epithelial cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0005942
subclass of: epidermal cell
subclass of: hair follicle cell
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0005942
IAO_0000115: An epithelial cell that is part of the outer root sheath.
created by: tmeehan
creation date: 2011-03-01T04:29:47Z
has OBO namespace: cell
id: CL:0002561

intestinal epithelial cell
type: Class
equivalent class: Class
  intersection of: epithelial cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0000160
subclass of: epithelial cell of alimentary canal
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0000160
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0001277
IAO_0000115: An epithelial cell of the intestine.
created by: tmeehan
creation date: 2011-03-01T05:18:31Z
has OBO namespace: cell
id: CL:0002563

mesenchymal stem cell of umbilical cord
type: Class
equivalent class: Class
  intersection of: mesenchymal stem cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0003422
subclass of: mesenchymal stem cell
subclass of: extraembryonic cell
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0003422
IAO_0000115: A mesenchymal stem cell of the umbilical cord.
created by: tmeehan
creation date: 2011-03-01T09:55:12Z
has OBO namespace: cell
id: CL:0002569

mesenchymal stem cell of adipose
type: Class
equivalent class: Class
  intersection of: mesenchymal stem cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0001013
subclass of: mesenchymal stem cell
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0001013
IAO_0000115: A mesenchymal stem cell of adipose tissue.
created by: tmeehan
creation date: 2011-03-01T09:57:17Z
has OBO namespace: cell
id: CL:0002570

hepatic mesenchymal stem cell
type: Class
equivalent class: Class
  intersection of: mesenchymal stem cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0002107
subclass of: mesenchymal stem cell
subclass of: hepatic stem cell
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0002107
IAO_0000115: A mesenchymal stem cell of liver.
created by: tmeehan
creation date: 2011-03-01T09:58:51Z
has OBO namespace: cell
id: CL:0002571

vertebral mesenchymal stem cell
type: Class
equivalent class: Class
  intersection of: mesenchymal stem cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0002412
subclass of: mesenchymal stem cell
subclass of: bone cell
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0002412
IAO_0000115: A mesenchymal stem cell of the vertebrae.
created by: tmeehan
creation date: 2011-03-01T10:40:27Z
has OBO namespace: cell
id: CL:0002572

Schwann cell
type: Class
equivalent class: Class
  intersection of: glial cell (sensu Vertebrata)
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0000010
subclass of: glial cell (sensu Vertebrata)
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0000010
IAO_0000115: A glial cell that ensheathes axons of neuron in the peripheral nervous system and are necessary for their maintainance and function.
created by: tmeehan
creation date: 2011-03-02T01:19:27Z
database_cross_reference: BTO:0001220
database_cross_reference: CALOHA:TS-0898
has OBO namespace: cell
id: CL:0002573

stromal cell of pancreas
type: Class
equivalent class: Class
  intersection of: stromal cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0001264
subclass of: stromal cell
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0001264
IAO_0000115: A stromal cell of the pancreas.
created by: tmeehan
creation date: 2011-03-02T02:40:41Z
has OBO namespace: cell
id: CL:0002574

central nervous system pericyte
type: Class
equivalent class: Class
  intersection of: pericyte cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0001017
subclass of: pericyte cell
subclass of: neural cell
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0001017
IAO_0000115: A pericyte of the central nervous system.
created by: tmeehan
creation date: 2011-03-02T02:54:18Z
has OBO namespace: cell
id: CL:0002575

perineural cell
type: Class
equivalent class: Class
  intersection of: myofibroblast cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0000121
subclass of: myofibroblast cell
subclass of: neural cell
subclass of: connective tissue cell
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0000121
IAO_0000115: A myofibroblast that lies in the connective tissue of the spinal cord that has a distinctly lamellar arrangement.
created by: tmeehan
creation date: 2011-03-02T03:03:58Z
has OBO namespace: cell
id: CL:0002576

placental epithelial cell
type: Class
equivalent class: Class
  intersection of: epithelial cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0001987
subclass of: epithelial cell
subclass of: extraembryonic cell
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0001987
IAO_0000115: An epithelial cell of the placenta.
created by: tmeehan
creation date: 2011-03-02T03:21:30Z
has OBO namespace: cell
id: CL:0002577

renal cortical epithelial cell
type: Class
equivalent class: Class
  intersection of: kidney epithelial cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0001225
subclass of: kidney epithelial cell
subclass of: kidney cortical cell
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0001225
IAO_0000115: An epithelial cell of the kidney cortex.
database_cross_reference: KUPO:0001016
has OBO namespace: cell
id: CL:0002584

retinal blood vessel endothelial cell
type: Class
equivalent class: Class
  intersection of: blood vessel endothelial cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0000966
subclass of: blood vessel endothelial cell
subclass of: retinal cell
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0000966
IAO_0000115: A blood vessel endothelial cell that is part of the retina.
created by: tmeehan
creation date: 2011-03-06T03:28:27Z
has OBO namespace: cell
id: CL:0002585

smooth muscle cell of the brachiocephalic vasculature
type: Class
equivalent class: Class
  intersection of: vascular associated smooth muscle cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0001529
subclass of: vascular associated smooth muscle cell
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0001529
IAO_0000115: A smooth muscle cell of the bachiocephalic vasculature.
created by: tmeehan
creation date: 2011-03-06T05:00:58Z
has OBO namespace: cell
id: CL:0002589

smooth muscle cell of the brain vasculature
type: Class
equivalent class: Class
  intersection of: vascular associated smooth muscle cell
  intersection of: Restriction
    on property: part_of
    some values from: Class
      intersection of: UBERON_0002049
      intersection of: Restriction
        on property: part_of
        some values from: UBERON_0000955
subclass of: vascular associated smooth muscle cell
subclass of: neural cell
subclass of: Restriction
  on property: part_of
  some values from: Class
    intersection of: UBERON_0002049
    intersection of: Restriction
      on property: part_of
      some values from: UBERON_0000955
IAO_0000115: A vascular associated smooth muscle cell of the brain vasculature.
created by: tmeehan
creation date: 2011-03-06T05:01:20Z
has OBO namespace: cell
id: CL:0002590

smooth muscle cell of the pulmonary artery
type: Class
equivalent class: Class
  intersection of: vascular associated smooth muscle cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0002012
subclass of: vascular associated smooth muscle cell
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0002012
IAO_0000115: A smooth muscle of the pulmonary artery.
created by: tmeehan
creation date: 2011-03-06T05:01:28Z
database_cross_reference: BTO:0003336
has OBO namespace: cell
id: CL:0002591

smooth muscle cell of the internal thoracic artery
type: Class
equivalent class: Class
  intersection of: vascular associated smooth muscle cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0002456
subclass of: smooth muscle cell of the subclavian artery
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0002456
IAO_0000115: A smooth muscle of the internal thoracic artery.
created by: tmeehan
creation date: 2011-03-06T05:01:41Z
has OBO namespace: cell
id: CL:0002593

smooth muscle cell of the umbilical artery
type: Class
equivalent class: Class
  intersection of: vascular associated smooth muscle cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0001310
subclass of: vascular associated smooth muscle cell
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0001310
IAO_0000115: A smooth muscle cell of the umbilical artery.
created by: tmeehan
creation date: 2011-03-06T05:01:48Z
has OBO namespace: cell
id: CL:0002594

smooth muscle cell of the subclavian artery
type: Class
equivalent class: Class
  intersection of: vascular associated smooth muscle cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0001533
subclass of: vascular associated smooth muscle cell
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0001533
IAO_0000115: A smooth muscle cell of the subclavian artery.
created by: tmeehan
creation date: 2011-03-06T05:01:52Z
has OBO namespace: cell
id: CL:0002595

smooth muscle cell of the carotid artery
type: Class
equivalent class: Class
  intersection of: vascular associated smooth muscle cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0005396
subclass of: vascular associated smooth muscle cell
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0005396
IAO_0000115: Smooth muscle cell of the carotid artery.
created by: tmeehan
creation date: 2011-03-06T05:01:56Z
has OBO namespace: cell
id: CL:0002596

smooth muscle cell of bladder
type: Class
equivalent class: Class
  intersection of: smooth muscle cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0001255
subclass of: smooth muscle cell
subclass of: bladder cell
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0001255
IAO_0000115: A smooth muscle cell of the bladder.
created by: tmeehan
creation date: 2011-03-06T05:43:24Z
database_cross_reference: KUPO:0001122
has OBO namespace: cell
id: CL:0002597

bronchial smooth muscle cell
type: Class
equivalent class: Class
  intersection of: smooth muscle cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0002185
subclass of: smooth muscle cell
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0002185
created by: tmeehan
creation date: 2011-03-06T05:46:39Z
database_cross_reference: BTO:0004402
has OBO namespace: cell
id: CL:0002598

smooth muscle cell of the esophagus
type: Class
equivalent class: Class
  intersection of: smooth muscle cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0001043
subclass of: smooth muscle cell
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0001043
IAO_0000115: A smooth muscle cell of the esophagus.
created by: tmeehan
creation date: 2011-03-06T05:48:17Z
has OBO namespace: cell
id: CL:0002599

smooth muscle cell of trachea
type: Class
equivalent class: Class
  intersection of: smooth muscle cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0003126
subclass of: smooth muscle cell
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0003126
IAO_0000115: A smooth muscle cell of the trachea.
created by: tmeehan
creation date: 2011-03-06T05:50:28Z
has OBO namespace: cell
id: CL:0002600

uterine smooth muscle cell
type: Class
equivalent class: Class
  intersection of: smooth muscle cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0000995
subclass of: smooth muscle cell
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0000995
IAO_0000115: A smooth muscle cell of the uterus.
created by: tmeehan
creation date: 2011-03-06T05:53:28Z
has OBO namespace: cell
id: CL:0002601

astrocyte of the cerebellum
type: Class
equivalent class: Class
  intersection of: astrocyte
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0002037
subclass of: astrocyte
subclass of: brain macroglial cell
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0002037
IAO_0000115: An astrocyte of the cerebellum.
created by: tmeehan
creation date: 2011-03-06T06:57:27Z
has OBO namespace: cell
id: CL:0002603

astrocyte of the cerebral cortex
type: Class
equivalent class: Class
  intersection of: astrocyte
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0000956
subclass of: astrocyte of the forebrain
subclass of: cerebral cortex glial cell
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0000956
IAO_0000115: An astrocyte of the cerebral cortex.
created by: tmeehan
creation date: 2011-03-06T06:57:36Z
has OBO namespace: cell
id: CL:0002605

astrocyte of the spinal cord
type: Class
equivalent class: Class
  intersection of: astrocyte
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0002240
subclass of: astrocyte
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0002240
IAO_0000115: An astrocyte of the spinal cord.
created by: tmeehan
creation date: 2011-03-06T07:11:26Z
has OBO namespace: cell
id: CL:0002606

neuron of cerebral cortex
type: Class
equivalent class: Class
  intersection of: CNS neuron (sensu Vertebrata)
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0000956
subclass of: cerebral cortex neuron
subclass of: neuron of the forebrain
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0000956
IAO_0000115: A CNS neuron of the cerebral cortex.
created by: tmeehan
creation date: 2011-03-06T07:37:08Z
database_cross_reference: BTO:0004102
database_cross_reference: FMA:84104
has exact synonym: cortical neuron
has OBO namespace: cell
id: CL:0002609

raphe nuclei neuron
type: Class
equivalent class: Class
  intersection of: CNS neuron (sensu Vertebrata)
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0004684
subclass of: CNS neuron (sensu Vertebrata)
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0004684
IAO_0000115: A neuron of the raphe nuclei.
created by: tmeehan
creation date: 2011-03-06T07:42:06Z
has OBO namespace: cell
id: CL:0002610

adipocyte of breast
type: Class
equivalent class: Class
  intersection of: fat cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0000310
subclass of: fat cell
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0000310
IAO_0000115: A fat cell that is part of the breast.
created by: tmeehan
creation date: 2011-03-14T10:17:07Z
database_cross_reference: CALOHA:TS-2377
has exact synonym: breast adipocyte
has exact synonym: fat cell of breast
has OBO namespace: cell
id: CL:0002617
comment: Adipocytes found in the subcutaneous adipose tissue of breast. The breast consists of three main components, the skin, the subcutaneous adipose tissue and the functional glandular tissue that comprises both parenchyma and stroma.[CALOHA]

skin fibroblast
type: Class
equivalent class: Class
  intersection of: fibroblast
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0002097
subclass of: fibroblast
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0002097
IAO_0000115: A fibroblast of skin.
created by: tmeehan
creation date: 2011-03-14T12:31:49Z
database_cross_reference: BTO:0001255
database_cross_reference: CALOHA:TS-0935
has OBO namespace: cell
id: CL:0002620

gingival epithelial cell
type: Class
equivalent class: Class
  intersection of: epithelial cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0001949
subclass of: epithelial cell of alimentary canal
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0001949
created by: tmeehan
creation date: 2011-03-14T12:46:28Z
has OBO namespace: cell
id: CL:0002621

prostate stromal cell
type: Class
equivalent class: Class
  intersection of: stromal cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0002367
subclass of: stromal cell
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0002367
IAO_0000115: A stromal cell of the prostate.
created by: tmeehan
creation date: 2011-03-14T02:11:10Z
database_cross_reference: BTO:0003972
has OBO namespace: cell
id: CL:0002622

acinar cell of salivary gland
type: Class
equivalent class: Class
  intersection of: acinar cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0001044
subclass of: acinar cell
subclass of: salivary gland glandular cell
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0001044
IAO_0000115: An acinar cell of salivary gland.
created by: tmeehan
creation date: 2011-03-14T02:22:22Z
has OBO namespace: cell
id: CL:0002623

seminiferous tubule epithelial cell
type: Class
equivalent class: Class
  intersection of: epithelial cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0001343
subclass of: duct epithelial cell
subclass of: mesothelial cell
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0001343
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0004813
IAO_0000115: A cell of the seminiferous tubule epithelium.
created by: tmeehan
creation date: 2011-03-15T11:59:23Z
has OBO namespace: cell
id: CL:0002625

epithelial cell of upper respiratory tract
type: Class
equivalent class: Class
  intersection of: respiratory epithelial cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0001557
subclass of: respiratory epithelial cell
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0001557
created by: tmeehan
creation date: 2011-06-21T12:28:55Z
has OBO namespace: cell
id: CL:0002631

epithelial cell of lower respiratory tract
type: Class
equivalent class: Class
  intersection of: respiratory epithelial cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0001558
subclass of: respiratory epithelial cell
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0001558
created by: tmeehan
creation date: 2011-06-21T12:29:31Z
has OBO namespace: cell
id: CL:0002632

epithelial cell of anal column
type: Class
equivalent class: Class
  intersection of: epithelial cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0009882
subclass of: epithelial cell of large intestine
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0009882
IAO_0000115: An epithelial cell of the anal column.
created by: tmeehan
creation date: 2011-07-08T12:11:38Z
has OBO namespace: cell
id: CL:0002634

keratinized epithelial cell of the anal canal
type: Class
equivalent class: Class
  intersection of: keratinizing barrier epithelial cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0000159
subclass of: keratinizing barrier epithelial cell
subclass of: epithelial cell of anal column
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0000159
IAO_0000115: An epithelial cell of the anal canal that is keratinized. This cell type is found towards the lower, rectal end of the anal canal.
created by: tmeehan
creation date: 2011-07-08T02:08:40Z
has OBO namespace: cell
id: CL:0002637

glandular cell of endometrium
type: Class
equivalent class: Class
  intersection of: glandular epithelial cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0001295
subclass of: oviduct glandular cell
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0001295
IAO_0000115: A glandular epithelial cell of the endometrium.
created by: tmeehan
creation date: 2011-07-08T03:54:08Z
database_cross_reference: FMA:86489
has OBO namespace: cell
id: CL:0002656

glandular cell of esophagus
type: Class
equivalent class: Class
  intersection of: glandular epithelial cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0001043
subclass of: glandular epithelial cell
subclass of: epithelial cell of esophagus
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0001043
IAO_0000115: A glandular epithelial cell of the esophagus.
created by: tmeehan
creation date: 2011-07-08T03:55:57Z
database_cross_reference: FMA:86548
has OBO namespace: cell
id: CL:0002657

glandular cell of the large intestine
type: Class
equivalent class: Class
  intersection of: glandular epithelial cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0000059
subclass of: glandular epithelial cell
subclass of: epithelial cell of large intestine
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0000059
IAO_0000115: A glandular epithelial cell of the large intestine.
created by: tmeehan
creation date: 2011-07-08T04:03:01Z
database_cross_reference: FMA:87194
has OBO namespace: cell
id: CL:0002658

glandular cell of stomach
type: Class
equivalent class: Class
  intersection of: glandular epithelial cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0000945
subclass of: glandular epithelial cell
subclass of: epithelial cell of stomach
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0000945
IAO_0000115: A glandular epithelial cell that is part of the stomach.
created by: tmeehan
creation date: 2011-07-11T01:20:35Z
database_cross_reference: CALOHA:TS-1284
database_cross_reference: FMA:86554
has OBO namespace: cell
id: CL:0002659

myocardial endocrine cell of atrium
type: Class
equivalent class: Class
  intersection of: myocardial endocrine cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0002081
subclass of: myocardial endocrine cell
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0002081
IAO_0000115: A myocardial endocrine cell that is part of the atrium.
created by: tmeehan
creation date: 2011-07-11T02:45:39Z
database_cross_reference: FMA:83389
has OBO namespace: cell
id: CL:0002663

retinal progenitor cell
type: Class
subclass of: multi fate stem cell
subclass of: Restriction
  on property: develops_from
  some values from: neurectodermal cell
IAO_0000115: A multi-fate stem cell that can give rise to different retinal cell types including rod and cone cells.
created by: tmeehan
creation date: 2011-08-16T02:38:01Z
has OBO namespace: cell
id: CL:0002672

tongue muscle cell
type: Class
equivalent class: Class
  intersection of: skeletal muscle fiber
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0000378
subclass of: skeletal muscle fiber
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0000378
IAO_0000115: A skeletal muscle cell that is part of the tongue.
created by: tmeehan
creation date: 2011-08-16T03:10:02Z
has OBO namespace: cell
id: CL:0002673

neural crest derived neuroblast
type: Class
subclass of: neuroblast (sensu Vertebrata)
subclass of: Restriction
  on property: develops_from
  some values from: migratory neural crest cell
IAO_0000115: A neuroblast derived from a neural crest cell.
created by: tmeehan
creation date: 2011-08-22T09:24:15Z
has OBO namespace: cell
id: CL:0002676

PP cell of intestine
type: Class
equivalent class: Class
  intersection of: PP cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0000160
subclass of: PP cell
subclass of: intestinal enteroendocrine cell
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0000160
IAO_0000115: A PP cell found in intestine.
created by: tmeehan
creation date: 2011-09-27T11:59:01Z
has OBO namespace: cell
id: CL:0002680

kidney cortical cell
type: Class
equivalent class: Class
  intersection of: kidney cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0001225
subclass of: kidney cell
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0001225
created by: terryh
creation date: 2011-10-25T03:49:41Z
has OBO namespace: cell
id: CL:0002681

spinal cord interneuron
type: Class
equivalent class: Class
  intersection of: interneuron
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0002240
subclass of: CNS interneuron
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0002240
IAO_0000115: A CNS interneuron located in the spinal cord.
has OBO namespace: cell
id: CL:0005000
comment: Is_a interneuron, part_of UBERON:0002240.

renal principal cell
type: Class
subclass of: columnar/cuboidal epithelial cell
subclass of: kidney epithelial cell
IAO_0000115: A cuboidal epithelial cell of the kidney which regulates sodium and potassium balance. The activity of sodium and potassium channels on the cells apical membrane is regulated by aldosterone and vasopressin. In mammals these cells are located in the renal collecting ducts.
has OBO namespace: cell
id: CL:0005009

multi-ciliated epithelial cell
type: Class
subclass of: ciliated cell
subclass of: epithelial cell
IAO_0000115: A ciliated epithelial cell with many cilium.
has OBO namespace: cell
id: CL:0005012

lymphangioblast
type: Class
subclass of: multi fate stem cell
IAO_0000115: Lymphatic progenitor cells.
created by: Ceri
creation date: 2012-01-12T04:44:34Z
has OBO namespace: cell
id: CL:0005020
comment: Usually express Prox1, or prox1b.

vascular lymphangioblast
type: Class
subclass of: lymphangioblast
IAO_0000115: Lymphatic progenitor cells, derived from the veins, that give rise to lymphatic endothelial cells.
created by: Ceri
creation date: 2012-01-12T05:21:09Z
has narrow synonym: parachordal lymphangioblast
has OBO namespace: cell
id: CL:0005022

hepatoblast
type: Class
subclass of: multi fate stem cell
IAO_0000115: Multi fate stem cell that gives rise to to both hepatocytes and cholangiocytes as descendants.
id: CL:0005026

skeletogenic cell
type: Class
subclass of: native cell
IAO_0000115: Cell that has the potential to form a skeletal cell type (e.g. cells in periosteum, cells in marrow) and produce extracellular matrix (often mineralized) and skeletal tissue (often mineralized).
created by: haendel
creation date: 2012-06-15T02:51:27Z
has exact synonym: scleroblast
has OBO namespace: cell
id: CL:0007001
comment: Needs logical definition. Should be capable_of skeletal system morphogenesis? or skeletal tissue development? needs to be added to GO. NOTES:a cell type of the early embryo (see also: mesenchymal cells) that will give rise to mineralized connective tissue. Scleroblasts can differentiate into osteoblasts (bone-forming cells), chondroblasts (cartilage-forming cells), odontoblasts (dentin-forming cells), ameloblasts (enamel-forming cells). The mesenchymal cells developing into osteoblasts and chondroblasts are derived from the mesoderm. Those developing into odontoblasts are neural crest cells. Those developing into ameloblasts are derived from the ectoderm. (http://www.copewithcytokines.de/cope.cgi?key=scleroblasts)

precementoblast
type: Class
subclass of: non-terminally differentiated cell
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0005176
IAO_0000115: Skeletogenic cell that has the potential to develop into a cementoblast.
created by: haendel
creation date: 2012-06-15T04:37:13Z
has OBO namespace: cell
id: CL:0007002

preodontoblast
type: Class
subclass of: non-terminally differentiated cell
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0005176
subclass of: Restriction
  on property: develops_from
  some values from: migratory cranial neural crest cell
IAO_0000115: Skeletogenic cell that has the potential to form an odontoblast, deposits predentine, and arises from a cranial neural crest cell.
created by: haendel
creation date: 2012-06-15T05:15:11Z
has OBO namespace: cell
id: CL:0007003

premigratory neural crest cell
type: Class
subclass of: neural crest cell
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0002342
subclass of: Restriction
  on property: develops_from
  some values from: neurectodermal cell
IAO_0000115: Cell that is part of the neural crest region of the neuroepithelium, prior to migration. Note that not all premigratory neural crest cells may become migratory neural crest cells.
created by: haendel
creation date: 2012-06-27T08:27:35Z
has OBO namespace: cell
id: CL:0007004

prechondroblast
type: Class
subclass of: non-terminally differentiated cell
IAO_0000115: Skeletogenic cell that has the potential to develop into a chondroblast; and arises from neural crest, meseosdermal and notochordal and connective tissue cells.
created by: haendel
creation date: 2012-06-27T10:44:01Z
has OBO namespace: cell
id: CL:0007009

preosteoblast
type: Class
subclass of: non-terminally differentiated cell
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0008883
subclass of: Restriction
  on property: develops_from
  some values from: mesodermal cell
subclass of: Restriction
  on property: develops_from
  some values from: migratory neural crest cell
IAO_0000115: Skeletogenic cell that has the potential to transform into an osteoblast, and develops from neural crest or mesodermal cells.
created by: haendel
creation date: 2012-06-27T10:57:21Z
has exact synonym: osteoprogenitor cell
has OBO namespace: cell
id: CL:0007010

non-striated muscle cell
type: Class
subclass of: muscle cell
IAO_0000115: Any muscle cell in which the fibers are not organised into sarcomeres.
id: CL:0008000

hematopoietic precursor cell
type: Class
subclass of: hematopoietic cell
IAO_0000115: Any hematopoietic cell that is a precursor of some other hematopoietic cell type.
id: CL:0008001

skeletal muscle fiber
type: Class
subclass of: cell of skeletal muscle
subclass of: myotube
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0001134
subclass of: Restriction
  on property: has_part
  some values from: GO_0030017
subclass of: Restriction
  on property: develops_from
  some values from: skeletal muscle myoblast
IAO_0000115: A transversely striated, synctial cell of skeletal muscle. It is formed when proliferating myoblasts exit the cell cycle, differentiate and fuse.
id: CL:0008002

visceral muscle cell
type: Class
subclass of: muscle cell
IAO_0000115: A muscle cell that is part of some visceral muscle
id: CL:0008007

mesenchymal cell
type: Class
subclass of: motile cell
subclass of: somatic cell
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0003104
subclass of: Restriction
  on property: capable of
  some values from: cell migration
IAO_0000115: A non-polarised cell precursor cell that is part of some mesenchyme, is associated with the cell matrix but is not connected to other cells and is capable of migration.
has exact synonym: mesenchyme cell
id: CL:0008019

pancreatic endocrine cell
type: Class
equivalent class: Class
  intersection of: endocrine cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0001264
subclass of: endocrine cell
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0001264
IAO_0000115: An endocrine cell that is part of the pancreas.
has OBO namespace: cell
id: CL:0008024

sensory neuron of spinal nerve
type: Class
equivalent class: Class
  intersection of: sensory neuron
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0001780
subclass of: sensory neuron
subclass of: peripheral nervous system neuron
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0001780
IAO_0000115: A sensory neuron of the spinal nerve that senses body position and sends information about how much the muscle is stretched to the spinal cord.
has exact synonym: spinal sensory neuron
id: CL:0009000

retinal cell
type: Class
equivalent class: Class
  intersection of: neural cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0005388
subclass of: neural cell
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0005388
IAO_0000115: Any cell in the retina, the innermost layer or coating at the back of the eyeball, which is sensitive to light and in which the optic nerve terminates.
database_cross_reference: PMID:10702418
has OBO namespace: cell
id: CL:0009004

stromal cell of bone marrow
type: Class
equivalent class: Class
  intersection of: stromal cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0002371
subclass of: stromal cell
subclass of: bone marrow cell
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0002371
IAO_0000115: a stromal cell that is part_of a bone marrow
created by: GOC:cjm
has exact synonym: bone marrow stromal cell
id: CL:0010001

epithelial cell of umbilical artery
type: Class
equivalent class: Class
  intersection of: epithelial cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0001310
subclass of: BFO_0000004
subclass of: epithelial cell
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0001310
IAO_0000115: a epithelial cell that is part_of a umbilical artery
created by: GOC:cjm
has exact synonym: umbilical artery epithelial cell
id: CL:0010002

epithelial cell of alveolus of lung
type: Class
equivalent class: Class
  intersection of: epithelial cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0002299
subclass of: epithelial cell of lung
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0002299
IAO_0000115: a epithelial cell that is part_of a alveolus of lung
created by: GOC:cjm
has exact synonym: alveolus of lung epithelial cell
id: CL:0010003
comment: May be merged with pneumocyte in future

mononuclear cell of bone marrow
type: Class
equivalent class: Class
  intersection of: mononuclear cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0002371
subclass of: mononuclear cell
subclass of: bone marrow hematopoietic cell
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0002371
IAO_0000115: a mononuclear cell that is part_of a bone marrow
created by: GOC:cjm
has exact synonym: bone marrow mononuclear cell
id: CL:0010004

cardiac blood vessel endothelial cell
type: Class
equivalent class: Class
  intersection of: blood vessel endothelial cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0000948
subclass of: blood vessel endothelial cell
subclass of: cardiac endothelial cell
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0000948
id: CL:0010006

cardiac endothelial cell
type: Class
equivalent class: Class
  intersection of: endothelial cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0000948
subclass of: endothelial cell
subclass of: cardiocyte
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0000948
id: CL:0010008

camera-type eye photoreceptor cell
type: Class
equivalent class: Class
  intersection of: photoreceptor cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0000019
subclass of: eye photoreceptor cell
subclass of: retinal cell
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0000019
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0000966
has exact synonym: camera type eye photoreceptor cell
id: CL:0010009

cerebral cortex GABAergic interneuron
type: Class
equivalent class: Class
  intersection of: GABAergic interneuron
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0000956
subclass of: CNS interneuron
subclass of: neuron of cerebral cortex
subclass of: GABAergic interneuron
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0000956
IAO_0000115: a GABAergic interneuron that is part_of a cerebral cortex
id: CL:0010011

cerebral cortex neuron
type: Class
equivalent class: Class
  intersection of: neuron
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0000956
subclass of: central nervous system neuron
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0000956
IAO_0000115: a neuron that is part_of a cerebral cortex
id: CL:0010012

cardiac glial cell
type: Class
equivalent class: Class
  intersection of: glial cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0000948
subclass of: glial cell
subclass of: cardiocyte
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0000948
id: CL:0010020

cardiac myoblast
type: Class
subclass of: myoblast
has OBO namespace: cell
id: CL:0010021

cardiac neuron
type: Class
equivalent class: Class
  intersection of: neuron
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0000948
subclass of: neuron
subclass of: cardiocyte
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0000948
id: CL:0010022

spinal cord motor neuron
type: Class
equivalent class: Class
  intersection of: motor neuron
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0002240
subclass of: motor neuron
subclass of: central nervous system neuron
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0002240
IAO_0000115: A motor neuron that passes from the spinal cord toward or to a muscle and conducts an impulse that causes movement.
id: CL:0011001

GABAergic interneuron
type: Class
equivalent class: Class
  intersection of: interneuron
  intersection of: GABAergic neuron
subclass of: interneuron
subclass of: GABAergic neuron
IAO_0000115: An interneuron that uses GABA as a vesicular neurotransmitter.
id: CL:0011005

paraxial cell
type: Class
equivalent class: Class
  intersection of: mesodermal cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0003059
subclass of: mesodermal cell
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0003059
IAO_0000115: A cell in the area of mesoderm in the neurulating embryo that flanks and forms simultaneously with the neural tube. The cells of this region give rise to somites.
has exact synonym: paraxial mesoderm cell
has exact synonym: somitic mesoderm cell
has narrow synonym: presomitic mesoderm cell
id: CL:0011007

neural crest cell
type: Class
subclass of: multi fate stem cell
subclass of: embryonic cell
IAO_0000115: A cell of the neural crest. Neural crest cells are multipotent. Premigratory neural crest cells are found at the neural plate boarder, some of which will undergo ectomesynchymal transition and delamination to form migratory neural crest cells.
has OBO namespace: cell
id: CL:0011012

chorionic trophoblast cell
type: Class
equivalent class: Class
  intersection of: trophoblast cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0003124
subclass of: trophoblast cell
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0003124
IAO_0000115: Cells of the uterine chorion that acquire specialized structural and/or functional features that characterize chorionic trophoblasts. These cells will migrate towards the spongiotrophoblast layer and give rise to syncytiotrophoblasts of the labyrinthine layer.
id: CL:0011101

colon epithelial cell
type: Class
equivalent class: Class
  intersection of: epithelial cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0001155
subclass of: epithelial cell of large intestine
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0000397
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0001155
IAO_0000115: Epithelial cell that is part of the colon epithelium.
has exact synonym: colonic epithelial cell
id: CL:0011108

spiral ganglion neuron
type: Class
equivalent class: Class
  intersection of: neuron
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0000395
subclass of: neuron
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0000395
IAO_0000115: Neuron found in the spriral ganglion.
id: CL:0011113

precursor cell
type: Class
equivalent class: Class
  intersection of: native cell
  intersection of: Restriction
    on property: capable of
    some values from: cell differentiation
subclass of: material entity
subclass of: native cell
subclass of: Restriction
  on property: capable of
  some values from: cell differentiation
IAO_0000115: A cell that, by division or terminal differentiation, can give rise to other cell types.
id: CL:0011115
comment: Work is needed on GO 'cell differentiation' before it is clear whether the equivalent class definition 'native cell' that capable_of some 'cell differentiation' works. Also, may want to consider merging this with non-terminally differentiated cell.

astrocyte of the forebrain
type: Class
equivalent class: Class
  intersection of: astrocyte
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0001890
subclass of: astrocyte
subclass of: brain macroglial cell
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0001890
IAO_0000115: An astrocyte of the forebrain.
created by: tberardini
has exact synonym: forebrain astrocyte
has OBO namespace: cell
id: CL:0012000

neuron of the forebrain
type: Class
equivalent class: Class
  intersection of: CNS neuron (sensu Vertebrata)
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0001890
subclass of: CNS neuron (sensu Vertebrata)
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0001890
IAO_0000115: A CNS neuron of the forebrain.
created by: tberardini
has exact synonym: forebrain neuron
has OBO namespace: cell
id: CL:0012001

forebrain neuroblast
type: Class
equivalent class: Class
  intersection of: neuroblast
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0001890
subclass of: neuroblast
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0001890
id: CL:1000042

pronephric nephron tubule epithelial cell
type: Class
equivalent class: Class
  intersection of: epithelial cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0005310
subclass of: kidney tubule cell
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0005310
id: CL:1000090

metanephric nephron tubule epithelial cell
type: Class
equivalent class: Class
  intersection of: epithelial cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0005146
subclass of: kidney tubule cell
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0005146
id: CL:1000123

stomach neuroendocrine cell
type: Class
equivalent class: Class
  intersection of: neuroendocrine cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0000945
subclass of: neuroendocrine cell
subclass of: epithelial cell of stomach
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0000945
id: CL:1000222

lung neuroendocrine cell
type: Class
equivalent class: Class
  intersection of: neuroendocrine cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0002048
subclass of: epithelial cell of lung
subclass of: neuroendocrine cell
subclass of: lung secretory cell
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0002048
id: CL:1000223

lung ciliated cell
type: Class
equivalent class: Class
  intersection of: ciliated cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0002048
subclass of: BFO_0000004
subclass of: ciliated cell
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0002048
id: CL:1000271

lung secretory cell
type: Class
equivalent class: Class
  intersection of: secretory cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0002048
subclass of: secretory cell
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0002048
id: CL:1000272

trophectodermal cell
type: Class
subclass of: extraembryonic cell
has exact synonym: trophectoderm cell
has OBO namespace: cell
id: CL:1000274

smooth muscle cell of small intestine
type: Class
equivalent class: Class
  intersection of: enteric smooth muscle cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0002108
subclass of: enteric smooth muscle cell
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0002108
IAO_0000115: A smooth muscle cell that is part of the small intestine.
database_cross_reference: FMA:15050
has exact synonym: non-striated muscle fiber of small intestine
has OBO namespace: cell
id: CL:1000275

smooth muscle fiber of duodenum
type: Class
equivalent class: Class
  intersection of: smooth muscle cell of small intestine
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0002114
subclass of: smooth muscle cell of small intestine
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0002114
IAO_0000115: A smooth muscle cell that is part of the duodenum.
database_cross_reference: FMA:15058
has exact synonym: non-striated muscle fiber of duodenum
has OBO namespace: cell
id: CL:1000276

smooth muscle cell of large intestine
type: Class
equivalent class: Class
  intersection of: enteric smooth muscle cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0000059
subclass of: enteric smooth muscle cell
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0000059
IAO_0000115: A smooth muscle cell that is part of the large intestine.
database_cross_reference: FMA:15653
has exact synonym: non-striated muscle fiber of large intestine
has OBO namespace: cell
id: CL:1000279

smooth muscle cell of colon
type: Class
equivalent class: Class
  intersection of: enteric smooth muscle cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0001155
subclass of: smooth muscle cell of large intestine
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0001155
IAO_0000115: A smooth muscle cell that is part of the colon.
database_cross_reference: FMA:15663
has exact synonym: non-striated muscle fiber of colon
has OBO namespace: cell
id: CL:1000280

smooth muscle cell of cecum
type: Class
equivalent class: Class
  intersection of: smooth muscle cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0001153
subclass of: smooth muscle cell of colon
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0001153
IAO_0000115: A smooth muscle cell that is part of the cecum.
database_cross_reference: FMA:15681
has exact synonym: non-striated muscle fiber of cecum
has exact synonym: smooth muscle fiber of cecum
has OBO namespace: cell
id: CL:1000281

smooth muscle fiber of ascending colon
type: Class
equivalent class: Class
  intersection of: smooth muscle cell of colon
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0001156
subclass of: smooth muscle cell of colon
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0001156
IAO_0000115: A smooth muscle cell that is part of the ascending colon.
database_cross_reference: FMA:17518
has exact synonym: non-striated muscle fiber of ascending colon
has OBO namespace: cell
id: CL:1000282

smooth muscle fiber of transverse colon
type: Class
equivalent class: Class
  intersection of: smooth muscle cell of colon
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0001157
subclass of: smooth muscle cell of colon
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0001157
IAO_0000115: A smooth muscle cell that is part of the transverse colon.
database_cross_reference: FMA:17519
has exact synonym: non-striated muscle fiber of transverse colon
has OBO namespace: cell
id: CL:1000283

smooth muscle fiber of descending colon
type: Class
equivalent class: Class
  intersection of: smooth muscle cell of colon
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0001158
subclass of: smooth muscle cell of colon
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0001158
IAO_0000115: A smooth muscle cell that is part of the descending colon.
database_cross_reference: FMA:17520
has exact synonym: non-striated muscle fiber of descending colon
has OBO namespace: cell
id: CL:1000284

smooth muscle cell of sigmoid colon
type: Class
equivalent class: Class
  intersection of: smooth muscle cell of colon
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0001159
subclass of: smooth muscle cell of colon
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0001159
IAO_0000115: A smooth muscle cell that is part of the sigmoid colon.
database_cross_reference: FMA:17521
has exact synonym: non-striated muscle fiber of sigmoid colon
has OBO namespace: cell
id: CL:1000285

smooth muscle cell of rectum
type: Class
equivalent class: Class
  intersection of: smooth muscle cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0001052
subclass of: smooth muscle cell of large intestine
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0001052
IAO_0000115: A smooth muscle cell that is part of the rectum.
database_cross_reference: FMA:17522
has exact synonym: non-striated muscle fiber of rectum
has exact synonym: smooth muscle fiber of rectum
has OBO namespace: cell
id: CL:1000286

epithelial cell of urethra
type: Class
equivalent class: Class
  intersection of: epithelial cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0000057
subclass of: epithelial cell
subclass of: somatic cell
subclass of: urethra cell
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0000057
IAO_0000115: An epithelial cell that is part of the urethra.
database_cross_reference: FMA:256165
has OBO namespace: cell
id: CL:1000296

mesothelial cell of dura mater
type: Class
equivalent class: Class
  intersection of: mesothelial cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0002363
subclass of: mesothelial cell
subclass of: neural cell
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0002363
IAO_0000115: A mesothelial cell that is part of the dura mater.
database_cross_reference: FMA:256516
has exact synonym: squamous mesothelial cell of dura mater
has OBO namespace: cell
id: CL:1000298

fibroblast of areolar connective tissue
type: Class
equivalent class: Class
  intersection of: fibroblast
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0006815
subclass of: fibroblast
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0006815
IAO_0000115: A fibroblast that is part of the areolar connective tissue.
database_cross_reference: FMA:261279
has OBO namespace: cell
id: CL:1000303

fibroblast of tunica adventitia of artery
type: Class
equivalent class: Class
  intersection of: fibroblast
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0005734
subclass of: fibroblast
subclass of: adventitial cell
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0005734
IAO_0000115: A fibroblast that is part of the tunica adventitia of artery.
database_cross_reference: FMA:261285
has OBO namespace: cell
id: CL:1000306

fibroblast of dense regular elastic tissue
type: Class
equivalent class: Class
  intersection of: fibroblast
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0007846
subclass of: fibroblast
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0002521
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0007846
IAO_0000115: A fibroblast that is part of the dense regular elastic tissue.
database_cross_reference: FMA:261287
has OBO namespace: cell
id: CL:1000307

epicardial adipocyte
type: Class
subclass of: fat cell
subclass of: cardiocyte
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0002348
IAO_0000115: A fat cell that is part of the epicardial fat.
database_cross_reference: FMA:261293
has exact synonym: adipocyte of epicardial fat
has exact synonym: epicardial fat cell
has OBO namespace: cell
id: CL:1000309

adipocyte of epicardial fat of right ventricle
type: Class
equivalent class: Class
  intersection of: epicardial adipocyte
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0002080
subclass of: epicardial adipocyte
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0002080
IAO_0000115: A fat cell that is part of the epicardial fat of right ventricle.
database_cross_reference: FMA:261297
has exact synonym: epicardial adipocyte of right ventricle
has exact synonym: epicardial fat cell of right ventricle
has OBO namespace: cell
id: CL:1000310

adipocyte of epicardial fat of left ventricle
type: Class
equivalent class: Class
  intersection of: epicardial adipocyte
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0002084
subclass of: epicardial adipocyte
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0002084
IAO_0000115: A fat cell that is part of the epicardial fat of left ventricle.
database_cross_reference: FMA:261300
has exact synonym: epicardial adipocyte of left ventricle
has exact synonym: epicardial fat cell of left ventricle
has OBO namespace: cell
id: CL:1000311

serous cell of epithelium of trachea
type: Class
equivalent class: Class
  intersection of: serous secreting cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0001901
subclass of: serous secreting cell
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0001901
IAO_0000115: A serous secreting cell that is part of the epithelium of trachea.
database_cross_reference: FMA:263078
has OBO namespace: cell
id: CL:1000330

serous cell of epithelium of bronchus
type: Class
equivalent class: Class
  intersection of: serous secreting cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0002031
subclass of: serous secreting cell
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0002031
IAO_0000115: A serous secreting cell that is part of the epithelium of bronchus.
database_cross_reference: FMA:263080
has OBO namespace: cell
id: CL:1000331

serous cell of epithelium of terminal bronchiole
type: Class
equivalent class: Class
  intersection of: serous secreting cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0001958
subclass of: serous cell of epithelium of lobular bronchiole
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0001958
IAO_0000115: A serous secreting cell that is part of the epithelium of terminal bronchiole.
database_cross_reference: FMA:263082
has OBO namespace: cell
id: CL:1000332

serous cell of epithelium of lobular bronchiole
type: Class
equivalent class: Class
  intersection of: serous secreting cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0002051
subclass of: lung secretory cell
subclass of: serous cell of epithelium of bronchus
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0002051
IAO_0000115: A serous secreting cell that is part of the epithelium of bronchiole.
database_cross_reference: FMA:263084
has OBO namespace: cell
id: CL:1000333

enterocyte of epithelium of small intestine
type: Class
equivalent class: Class
  intersection of: enterocyte
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0001902
subclass of: enterocyte
subclass of: epithelial cell of small intestine
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0001902
IAO_0000115: An enterocyte that is part of the epithelium of small intestine.
database_cross_reference: FMA:263086
has OBO namespace: cell
id: CL:1000334

enterocyte of epithelium of intestinal villus
type: Class
equivalent class: Class
  intersection of: enterocyte
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0013636
subclass of: enterocyte of epithelium of small intestine
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0001213
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0013636
IAO_0000115: An enterocyte that is part of the epithelium of intestinal villus.
database_cross_reference: FMA:263088
has OBO namespace: cell
id: CL:1000335

enterocyte of epithelium of duodenal gland
type: Class
equivalent class: Class
  intersection of: enterocyte
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0001212
subclass of: tracheal epithelial cell
subclass of: enterocyte
subclass of: epithelial cell of small intestine
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0001212
IAO_0000115: An enterocyte that is part of the epithelium of duodenal gland.
database_cross_reference: FMA:263092
has OBO namespace: cell
id: CL:1000337

vacuolar absorptive cell of epithelium of colon
type: Class
equivalent class: Class
  intersection of: enterocyte of epithelium of large intestine
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0000397
subclass of: enterocyte of epithelium of large intestine
subclass of: colon epithelial cell
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0000397
IAO_0000115: A columnar cell of the colon that is part of the colonic epithelium.
database_cross_reference: FMA:263114
has OBO namespace: cell
id: CL:1000347

transitional myocyte of interatrial septum
type: Class
equivalent class: Class
  intersection of: transitional myocyte
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0002085
subclass of: transitional myocyte
subclass of: cardiac septum native cell
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0002085
IAO_0000115: A transitional myocyte that is part of the interatrial septum.
database_cross_reference: FMA:263152
has OBO namespace: cell
id: CL:1000361

transitional myocyte of interventricular septum
type: Class
equivalent class: Class
  intersection of: transitional myocyte
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0002094
subclass of: transitional myocyte
subclass of: cardiac septum native cell
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0002094
IAO_0000115: A transitional myocyte that is part of the interventricular septum.
database_cross_reference: FMA:263154
has OBO namespace: cell
id: CL:1000362

Purkinje myocyte of interventricular septum
type: Class
equivalent class: Class
  intersection of: Purkinje myocyte
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0002094
subclass of: Purkinje myocyte
subclass of: cardiac septum native cell
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0002094
IAO_0000115: A Purkinje myocyte that is part of the interventricular septum.
database_cross_reference: FMA:263182
has OBO namespace: cell
id: CL:1000376

melanocyte of eyelid
type: Class
equivalent class: Class
  intersection of: melanocyte
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0001711
subclass of: melanocyte
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0001711
IAO_0000115: A melanocyte that is part of the eyelid.
database_cross_reference: FMA:59175
has exact synonym: eyelid melanocyte
has exact synonym: sebaceous gland of wolff
has OBO namespace: cell
id: CL:1000391

endothelial cell of hepatic sinusoid
type: Class
equivalent class: Class
  intersection of: endothelial cell of sinusoid
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0001281
subclass of: endothelial cell of sinusoid
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0001281
IAO_0000115: An endothelial cell that is part of the hepatic sinusoid.
database_cross_reference: FMA:62911
has exact synonym: endotheliocyte of hepatic sinusoid
has OBO namespace: cell
id: CL:1000398

epithelial cell of appendix
type: Class
equivalent class: Class
  intersection of: epithelial cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0001154
subclass of: colon epithelial cell
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0001154
IAO_0000115: An epithelial cell that is part of the appendix.
database_cross_reference: FMA:63602
has exact synonym: columnar epitheliocyte of appendix
has exact synonym: epithelial cell of vermiform appendix
has OBO namespace: cell
id: CL:1000405

myocyte of sinoatrial node
type: Class
equivalent class: Class
  intersection of: muscle cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0002351
subclass of: nodal myocyte
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0002351
IAO_0000115: A muscle cell that is part of the sinoatrial node.
database_cross_reference: FMA:67102
has exact synonym: SA nodal myocyte
has exact synonym: SA node cardiac muscle cell
has exact synonym: myocyte of sinoatrial node
has exact synonym: sinoatrial node cell
has exact synonym: sinoatrial node myocyte
has exact synonym: sinuatrial node myocyte
has OBO namespace: cell
id: CL:1000409

myocyte of atrioventricular node
type: Class
equivalent class: Class
  intersection of: muscle cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0002352
subclass of: nodal myocyte
subclass of: cardiac septum native cell
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0002352
IAO_0000115: A muscle cell that is part of the atrioventricular node.
database_cross_reference: FMA:67106
has exact synonym: AV nodal myocyte
has exact synonym: AV node cardiac muscle cell
has exact synonym: AV node cell
has exact synonym: atrioventricular node cell
has exact synonym: atrioventricular node myocyte
has OBO namespace: cell
id: CL:1000410

endothelial cell of arteriole
type: Class
equivalent class: Class
  intersection of: endothelial cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0001980
subclass of: blood vessel endothelial cell
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0001980
IAO_0000115: An endothelial cell that is part of the arteriole.
database_cross_reference: FMA:67760
database_cross_reference: KUPO:0001097
has OBO namespace: cell
id: CL:1000412

endothelial cell of artery
type: Class
equivalent class: Class
  intersection of: endothelial cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0001637
subclass of: blood vessel endothelial cell
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0001637
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0001917
IAO_0000115: A blood vessel endothelial cell that is part of an arterial endothelium.
has alternative id: CL:0002542
database_cross_reference: BTO:0004758
database_cross_reference: FMA:67761
database_cross_reference: KUPO:0001095
has exact synonym: arterial endothelial cell
has OBO namespace: cell
id: CL:1000413

endothelial cell of venule
type: Class
equivalent class: Class
  intersection of: endothelial cell of vascular tree
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0001979
subclass of: endothelial cell of vascular tree
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0001979
IAO_0000115: An endothelial cell that is part of the venule.
database_cross_reference: FMA:67762
has OBO namespace: cell
id: CL:1000414

epithelial cell of gall bladder
type: Class
equivalent class: Class
  intersection of: epithelial cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0002110
subclass of: BFO_0000004
subclass of: epithelial cell
subclass of: somatic cell
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0002110
IAO_0000115: An epithelial cell that is part of the gallbladder.
database_cross_reference: FMA:67780
has OBO namespace: cell
id: CL:1000415

myoepithelial cell of lactiferous gland
type: Class
equivalent class: Class
  intersection of: myoepithelial cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0001911
subclass of: myoepithelial cell
subclass of: mammary gland epithelial cell
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0001911
IAO_0000115: A myoepithelial cell that is part of the mammary gland.
database_cross_reference: CALOHA:TS-2378
database_cross_reference: FMA:67800
has exact synonym: basal cell of lactiferous duct
has OBO namespace: cell
id: CL:1000416

myoepithelial cell of sweat gland
type: Class
equivalent class: Class
  intersection of: myoepithelial cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0001820
subclass of: myoepithelial cell
subclass of: epithelial cell of sweat gland
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0001820
IAO_0000115: A myoepithelial cell that is part of the sweat gland.
database_cross_reference: FMA:67801
has OBO namespace: cell
id: CL:1000417

myoepithelial cell of lactiferous alveolus
type: Class
equivalent class: Class
  intersection of: myoepithelial cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0003214
subclass of: myoepithelial cell of lactiferous gland
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0003214
IAO_0000115: A myoepithelial cell that is part of the mammary gland alveolus.
database_cross_reference: FMA:67802
has exact synonym: basal cell of alveolus of lactiferous gland
has exact synonym: myoepithelial cell of mammary alveolus
has OBO namespace: cell
id: CL:1000418

myoepithelial cell of lactiferous duct
type: Class
equivalent class: Class
  intersection of: myoepithelial cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0001765
subclass of: duct epithelial cell
subclass of: myoepithelial cell of lactiferous gland
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0001765
IAO_0000115: A myoepithelial cell that is part of the lactiferous duct.
database_cross_reference: FMA:67803
has OBO namespace: cell
id: CL:1000419

chromaffin cell of adrenal gland
type: Class
equivalent class: Class
  intersection of: chromaffin cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0002369
subclass of: glandular epithelial cell
subclass of: chromaffin cell
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0002369
IAO_0000115: A chromaffin cell that is part of the adrenal gland.
database_cross_reference: FMA:69794
has exact synonym: adrenal chromaffin cell
has OBO namespace: cell
id: CL:1000426

adrenal cortex chromaffin cell
type: Class
equivalent class: Class
  intersection of: chromaffin cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0001235
subclass of: chromaffin cell of adrenal gland
subclass of: adrenal gland glandular cell
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0001235
IAO_0000115: A chromaffin cell that is part of the adrenal cortex.
database_cross_reference: FMA:69795
has exact synonym: chromaffin cell of adrenal cortex
has OBO namespace: cell
id: CL:1000427
comment: Not clear this cell type exists. Can't call it a cortical adrenal cell because of different germ layer origin.

stem cell of epidermis
type: Class
equivalent class: Class
  intersection of: somatic stem cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0001003
subclass of: somatic stem cell
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0001003
IAO_0000115: A somatic stem cell that is part of the epidermis.
database_cross_reference: FMA:70541
has exact synonym: epidermal stem cell
has OBO namespace: cell
id: CL:1000428

conjunctival epithelial cell
type: Class
equivalent class: Class
  intersection of: epithelial cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0001811
subclass of: BFO_0000004
subclass of: epithelial cell
subclass of: somatic cell
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0001811
IAO_0000115: An epithelial cell that is part of the conjunctiva.
database_cross_reference: FMA:70552
has exact synonym: epithelial cell of conjunctiva
has OBO namespace: cell
id: CL:1000432

epithelial cell of external acoustic meatus
type: Class
equivalent class: Class
  intersection of: epithelial cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0001352
subclass of: BFO_0000004
subclass of: epithelial cell
subclass of: somatic cell
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0001352
IAO_0000115: An epithelial cell that is part of the external acoustic meatus.
database_cross_reference: FMA:70555
has OBO namespace: cell
id: CL:1000434

ciliary muscle cell
type: Class
equivalent class: Class
  intersection of: smooth muscle cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0001775
subclass of: smooth muscle cell
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0001775
IAO_0000115: A smooth muscle cell that is part of the ciliary body.
database_cross_reference: FMA:70610
has exact synonym: smooth muscle cell of ciliary body
has OBO namespace: cell
id: CL:1000443

mesothelial cell of anterior chamber of eye
type: Class
equivalent class: Class
  intersection of: mesothelial cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0001766
subclass of: mesothelial cell
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0001766
IAO_0000115: A mesothelial cell that is part of the anterior chamber of eyeball.
database_cross_reference: FMA:70615
has OBO namespace: cell
id: CL:1000444

myoepithelial cell of dilator pupillae
type: Class
equivalent class: Class
  intersection of: myoepithelial cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0001608
subclass of: myoepithelial cell
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0001608
IAO_0000115: A myoepithelial cell that is part of the dilatator pupillae.
database_cross_reference: FMA:70619
has OBO namespace: cell
id: CL:1000445

epithelial cell of stratum germinativum of esophagus
type: Class
equivalent class: Class
  intersection of: basal cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0001976
subclass of: basal cell
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0001976
IAO_0000115: A basal cell that is part of the epithelium of esophagus.
database_cross_reference: FMA:70731
has exact synonym: basal cell of esophageal epithelium
has OBO namespace: cell
id: CL:1000447

epithelial cell of sweat gland
type: Class
equivalent class: Class
  intersection of: epithelial cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0001820
subclass of: epidermal cell
subclass of: epithelial cell of skin gland
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0001820
IAO_0000115: An epithelial cell that is part of the sweat gland.
database_cross_reference: FMA:70952
has OBO namespace: cell
id: CL:1000448

epithelial cell of nephron
type: Class
equivalent class: Class
  intersection of: epithelial cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0001285
subclass of: kidney epithelial cell
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0001285
IAO_0000115: An epithelial cell that is part of the nephron.
database_cross_reference: FMA:70965
has OBO namespace: cell
id: CL:1000449

kidney collecting duct epithelial cell
type: Class
equivalent class: Class
  intersection of: non-branched duct epithelial cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0001232
subclass of: non-branched duct epithelial cell
subclass of: kidney collecting duct cell
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0001232
IAO_0000115: An epithelial cell that is part of the collecting duct of renal tubule.
database_cross_reference: FMA:70982
database_cross_reference: KUPO:0001059
has exact synonym: epithelial cell of renal collecting tubule
has OBO namespace: cell
id: CL:1000454

mesothelial cell of parietal peritoneum
type: Class
equivalent class: Class
  intersection of: mesothelial cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0001366
subclass of: mesothelial cell of peritoneum
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0001366
IAO_0000115: A mesothelial cell that is part of the parietal peritoneum.
database_cross_reference: FMA:72142
has OBO namespace: cell
id: CL:1000456

mesothelial cell of visceral peritoneum
type: Class
equivalent class: Class
  intersection of: mesothelial cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0001178
subclass of: mesothelial cell of peritoneum
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0001178
IAO_0000115: A mesothelial cell that is part of the visceral peritoneum.
database_cross_reference: FMA:72143
has OBO namespace: cell
id: CL:1000457

melanocyte of skin
type: Class
equivalent class: Class
  intersection of: melanocyte
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0002097
subclass of: melanocyte
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0002097
IAO_0000115: A melanocyte that is part of the skin of body.
database_cross_reference: CALOHA:TS-2374
database_cross_reference: FMA:72144
has exact synonym: skin melanocyte
has OBO namespace: cell
id: CL:1000458

chromaffin cell of ovary
type: Class
equivalent class: Class
  intersection of: chromaffin cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0000992
subclass of: chromaffin cell
subclass of: ovarian surface epithelial cell
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0000992
IAO_0000115: A chromaffin cell that is part of the ovary.
database_cross_reference: FMA:74319
has OBO namespace: cell
id: CL:1000465

chromaffin cell of right ovary
type: Class
equivalent class: Class
  intersection of: chromaffin cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0002118
subclass of: chromaffin cell of ovary
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0002118
IAO_0000115: A chromaffin cell that is part of the right ovary.
database_cross_reference: FMA:74320
has OBO namespace: cell
id: CL:1000466

chromaffin cell of left ovary
type: Class
equivalent class: Class
  intersection of: chromaffin cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0002119
subclass of: chromaffin cell of ovary
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0002119
IAO_0000115: A chromaffin cell that is part of the left ovary.
database_cross_reference: FMA:74321
has OBO namespace: cell
id: CL:1000467

transitional myocyte of sinoatrial node
type: Class
equivalent class: Class
  intersection of: transitional myocyte
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0002351
subclass of: transitional myocyte
subclass of: myocyte of sinoatrial node
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0002351
IAO_0000115: A transitional myocyte that is part of the sinoatrial node.
database_cross_reference: FMA:83384
has exact synonym: transitinal myocyte of sinuatrial node
has OBO namespace: cell
id: CL:1000478

Purkinje myocyte of atrioventricular node
type: Class
equivalent class: Class
  intersection of: Purkinje myocyte
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0002352
subclass of: Purkinje myocyte
subclass of: myocyte of atrioventricular node
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0002352
IAO_0000115: A Purkinje myocyte that is part of the atrioventricular node.
database_cross_reference: FMA:83386
has OBO namespace: cell
id: CL:1000479

myocardial endocrine cell of interventricular septum
type: Class
equivalent class: Class
  intersection of: myocardial endocrine cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0002094
subclass of: myocardial endocrine cell
subclass of: cardiac septum native cell
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0002094
IAO_0000115: A myocardial endocrine cell that is part of the interventricular septum.
database_cross_reference: FMA:83390
has OBO namespace: cell
id: CL:1000482

basal cell of urothelium
type: Class
equivalent class: Class
  intersection of: basal cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0000365
subclass of: basal cell
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0000365
IAO_0000115: A basal cell that is part of the urothelium.
database_cross_reference: FMA:84150
has OBO namespace: cell
id: CL:1000486

smooth muscle cell of prostate
type: Class
equivalent class: Class
  intersection of: smooth muscle cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0002367
subclass of: smooth muscle cell
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0002367
IAO_0000115: A smooth muscle cell that is part of the prostate gland.
database_cross_reference: FMA:84583
has exact synonym: smooth muscle fiber of prostate
has OBO namespace: cell
id: CL:1000487

cholangiocyte
type: Class
equivalent class: Class
  intersection of: branched duct epithelial cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0002394
  intersection of: Restriction
    on property: capable of
    some values from: GO_0015106
subclass of: material entity
subclass of: branched duct epithelial cell
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0002394
subclass of: Restriction
  on property: develops_from
  some values from: hepatoblast
subclass of: Restriction
  on property: capable of
  some values from: GO_0015106
subclass of: Restriction
  on property: capable of
  some values from: Class
    intersection of: GO_0015106
    intersection of: Restriction
      on property: part_of
      some values from: GO_0032782
IAO_0000115: An epithelial cell that is part of the bile duct. Cholangiocytes contribute to bile secretion via net release of bicarbonate and water. They are cuboidal epithelium in the small interlobular bile ducts, but become columnar and mucus secreting in larger bile ducts approaching the porta hepatis and the extrahepatic ducts.
database_cross_reference: FMA:86481
has exact synonym: epithelial cell of bile duct
has OBO namespace: cell
id: CL:1000488

mesothelial cell of peritoneum
type: Class
equivalent class: Class
  intersection of: mesothelial cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0002358
subclass of: mesothelial cell
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0002358
IAO_0000115: A mesothelial cell that is part of the peritoneum.
database_cross_reference: FMA:86736
has exact synonym: peritoneal mesothelial cell
has OBO namespace: cell
id: CL:1000490

mesothelial cell of pleura
type: Class
equivalent class: Class
  intersection of: mesothelial cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0000977
subclass of: mesothelial cell
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0000977
IAO_0000115: A mesothelial cell that is part of the pleura.
database_cross_reference: FMA:86737
has exact synonym: pleural mesothelial cell
has OBO namespace: cell
id: CL:1000491

mesothelial cell of parietal pleura
type: Class
equivalent class: Class
  intersection of: mesothelial cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0002400
subclass of: mesothelial cell of pleura
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0002400
IAO_0000115: A mesothelial cell that is part of the parietal pleura.
database_cross_reference: FMA:86738
has OBO namespace: cell
id: CL:1000492

mesothelial cell of visceral pleura
type: Class
equivalent class: Class
  intersection of: mesothelial cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0002401
subclass of: epithelial cell of lung
subclass of: mesothelial cell of pleura
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0002401
IAO_0000115: A mesothelial cell that is part of the visceral pleura.
database_cross_reference: FMA:86739
has OBO namespace: cell
id: CL:1000493

nephron tubule epithelial cell
type: Class
equivalent class: Class
  intersection of: epithelial cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0004810
subclass of: kidney tubule cell
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0004810
IAO_0000115: An epithelial cell that is part of a nephron tubule.
database_cross_reference: FMA:86785
database_cross_reference: KUPO:0001022
has exact synonym: kidney tubule epithelial cell
has OBO namespace: cell
id: CL:1000494
comment: This needs to be further defined as a juxtamedullary nephron. Will request the juxtamedullary nephron tubule class from UBERON.

kidney cell
type: Class
equivalent class: Class
  intersection of: animal cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0002113
subclass of: BFO_0000004
subclass of: animal cell
subclass of: somatic cell
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0002113
database_cross_reference: KUPO:0001010
has OBO namespace: cell
id: CL:1000497

kidney interstitial cell
type: Class
equivalent class: Class
  intersection of: kidney cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0005215
subclass of: kidney cell
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0005215
database_cross_reference: KUPO:0001013
has OBO namespace: cell
id: CL:1000500

kidney medulla cell
type: Class
equivalent class: Class
  intersection of: kidney cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0000362
subclass of: kidney cell
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0000362
database_cross_reference: KUPO:0001017
has OBO namespace: cell
id: CL:1000504

kidney pelvis cell
type: Class
equivalent class: Class
  intersection of: kidney cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0001224
subclass of: kidney cell
subclass of: ureteral cell
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0001224
database_cross_reference: KUPO:0001018
has OBO namespace: cell
id: CL:1000505

kidney tubule cell
type: Class
equivalent class: Class
  intersection of: kidney cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0001231
subclass of: epithelial cell of nephron
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0001231
database_cross_reference: KUPO:0001020
has OBO namespace: cell
id: CL:1000507

kidney medulla collecting duct epithelial cell
type: Class
equivalent class: Class
  intersection of: kidney cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0005185
subclass of: kidney medulla cell
subclass of: kidney collecting duct cell
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0005185
database_cross_reference: KUPO:0001060
has OBO namespace: cell
id: CL:1000546

lower urinary tract cell
type: Class
equivalent class: Class
  intersection of: animal cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0001556
subclass of: BFO_0000002
subclass of: animal cell
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0001556
database_cross_reference: KUPO:0001115
has OBO namespace: cell
id: CL:1000600

ureteral cell
type: Class
equivalent class: Class
  intersection of: animal cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0000056
subclass of: BFO_0000004
subclass of: animal cell
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0000056
database_cross_reference: KUPO:0001116
has OBO namespace: cell
id: CL:1000601

kidney nerve cell
type: Class
equivalent class: Class
  intersection of: neuron
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0002113
subclass of: neuron
subclass of: kidney interstitial cell
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0002113
database_cross_reference: KUPO:0001015
has OBO namespace: cell
id: CL:1000606

kidney cortex interstitial cell
type: Class
equivalent class: Class
  intersection of: kidney interstitial cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0005270
subclass of: renal cortical epithelial cell
subclass of: kidney interstitial cell
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0005270
database_cross_reference: KUPO:0001091
has OBO namespace: cell
id: CL:1000681

kidney medulla interstitial cell
type: Class
equivalent class: Class
  intersection of: kidney interstitial cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0005211
subclass of: kidney interstitial cell
subclass of: kidney medulla cell
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0005211
database_cross_reference: KUPO:0001092
has OBO namespace: cell
id: CL:1000682

kidney interstitial fibroblast
type: Class
subclass of: fibroblast
subclass of: kidney interstitial cell
database_cross_reference: KUPO:0001102
has OBO namespace: cell
id: CL:1000692

kidney pelvis smooth muscle cell
type: Class
equivalent class: Class
  intersection of: smooth muscle cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0004227
subclass of: kidney pelvis cell
subclass of: ureter smooth muscle cell
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0004227
database_cross_reference: KUPO:0001113
has OBO namespace: cell
id: CL:1000702

kidney pelvis urothelial cell
type: Class
equivalent class: Class
  intersection of: kidney epithelial cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0004788
subclass of: kidney epithelial cell
subclass of: kidney pelvis cell
subclass of: ureter urothelial cell
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0004788
database_cross_reference: KUPO:0001114
has OBO namespace: cell
id: CL:1000703

ureter urothelial cell
type: Class
equivalent class: Class
  intersection of: urothelial cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0001254
subclass of: urothelial cell
subclass of: ureteral cell
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0001254
database_cross_reference: KUPO:0001117
has OBO namespace: cell
id: CL:1000706

ureter adventitial cell
type: Class
equivalent class: Class
  intersection of: ureteral cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0001252
subclass of: endothelial cell
subclass of: adventitial cell
subclass of: ureteral cell
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0001252
database_cross_reference: KUPO:0001119
has OBO namespace: cell
id: CL:1000708

kidney blood vessel cell
type: Class
equivalent class: Class
  intersection of: kidney medulla cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0003517
subclass of: renal cortical epithelial cell
subclass of: kidney medulla cell
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0003517
database_cross_reference: KUPO:0001014
has OBO namespace: cell
id: CL:1000854

kidney arterial blood vessel cell
type: Class
equivalent class: Class
  intersection of: kidney blood vessel cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0003644
subclass of: kidney blood vessel cell
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0003644
database_cross_reference: KUPO:0001029
has OBO namespace: cell
id: CL:1000891

kidney capillary endothelial cell
type: Class
equivalent class: Class
  intersection of: kidney blood vessel cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0003527
subclass of: blood vessel endothelial cell
subclass of: kidney blood vessel cell
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0003527
database_cross_reference: KUPO:0001030
has OBO namespace: cell
id: CL:1000892

kidney venous blood vessel cell
type: Class
equivalent class: Class
  intersection of: kidney blood vessel cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0001140
subclass of: kidney blood vessel cell
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0001140
database_cross_reference: KUPO:0001031
has OBO namespace: cell
id: CL:1000893

ureter smooth muscle cell
type: Class
equivalent class: Class
  intersection of: smooth muscle cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0006855
subclass of: smooth muscle cell
subclass of: ureteral cell
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0006855
database_cross_reference: KUPO:0001118
has OBO namespace: cell
id: CL:1000979

kidney cortex artery cell
type: Class
equivalent class: Class
  intersection of: kidney arterial blood vessel cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0005268
subclass of: kidney arterial blood vessel cell
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0005268
database_cross_reference: KUPO:0001077
has OBO namespace: cell
id: CL:1001045

kidney cortex vein cell
type: Class
equivalent class: Class
  intersection of: kidney venous blood vessel cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0005269
subclass of: kidney venous blood vessel cell
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0005269
database_cross_reference: KUPO:0001084
has OBO namespace: cell
id: CL:1001052

kidney collecting duct cell
type: Class
equivalent class: Class
  intersection of: kidney cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0001232
subclass of: epithelial cell of nephron
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0001232
database_cross_reference: KUPO:0001012
database_cross_reference: Wikipedia:Kidney_collecting_duct_cell
has OBO namespace: cell
id: CL:1001225

renal interstitial pericyte
type: Class
equivalent class: Class
  intersection of: pericyte cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0002113
subclass of: pericyte cell
subclass of: kidney cell
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0002113
database_cross_reference: KUPO:0001104
has OBO namespace: cell
id: CL:1001318

bladder cell
type: Class
equivalent class: Class
  intersection of: animal cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0001255
subclass of: BFO_0000004
subclass of: lower urinary tract cell
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0001255
database_cross_reference: KUPO:0001120
has OBO namespace: cell
id: CL:1001319

urethra cell
type: Class
equivalent class: Class
  intersection of: animal cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0000057
subclass of: BFO_0000004
subclass of: lower urinary tract cell
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0000057
database_cross_reference: KUPO:0001123
has OBO namespace: cell
id: CL:1001320

bladder urothelial cell
type: Class
equivalent class: Class
  intersection of: urothelial cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0004645
subclass of: urothelial cell
subclass of: bladder cell
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0004645
database_cross_reference: KUPO:0001121
has OBO namespace: cell
id: CL:1001428

urethra urothelial cell
type: Class
equivalent class: Class
  intersection of: urothelial cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0004787
subclass of: urothelial cell
subclass of: epithelial cell of urethra
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0004787
database_cross_reference: KUPO:0001124
has OBO namespace: cell
id: CL:1001430

kidney collecting duct principal cell
type: Class
equivalent class: Class
  intersection of: renal principal cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0001232
subclass of: renal principal cell
subclass of: kidney collecting duct epithelial cell
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0001232
database_cross_reference: KUPO:0001128
has OBO namespace: cell
id: CL:1001431

epithelial cell of exocrine pancreas
type: Class
equivalent class: Class
  intersection of: epithelial cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0000017
subclass of: epithelial cell of pancreas
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0000017
IAO_0000115: An epithelial cell of the exocrine pancreas.
database_cross_reference: FMA:70986
has exact synonym: exocrine pancreas cell
has OBO namespace: cell
id: CL:1001433

olfactory bulb interneuron
type: Class
equivalent class: Class
  intersection of: interneuron
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0002264
subclass of: sensory neuron
subclass of: CNS interneuron
subclass of: neuron of the forebrain
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0002264
IAO_0000115: A neuron residing in the olfactory bulb that serve to process and refine signals arising from olfactory sensory neurons
has OBO namespace: cl
id: CL:1001434

intestinal enteroendocrine cell
type: Class
equivalent class: Class
  intersection of: enteroendocrine cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0001242
subclass of: enteroendocrine cell
subclass of: intestinal epithelial cell
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0001242
IAO_0000115: the various hormone- or neurotransmitter-secreting cells present throughout the mucosa of the intestinal tract
has OBO namespace: cl
id: CL:1001516

lung endothelial cell
type: Class
equivalent class: Class
  intersection of: endothelial cell of vascular tree
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0002048
subclass of: epithelial cell of lung
subclass of: endothelial cell of vascular tree
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0000102
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0002048
has OBO namespace: cl
has related synonym: endothelial cell of lung
has related synonym: pulmonary vessel endothelial cell
id: CL:1001567

pulmonary artery endothelial cell
type: Class
equivalent class: Class
  intersection of: endothelial cell of vascular tree
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0002012
subclass of: endothelial cell of artery
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0002012
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0005317
database_cross_reference: BTO:0001141
has OBO namespace: cl
has related synonym: PAEC cell
id: CL:1001568

colon endothelial cell
type: Class
equivalent class: Class
  intersection of: endothelial cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0001155
subclass of: endothelial cell
subclass of: colon epithelial cell
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0001155
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0013695
IAO_0000115: Vascular endothelium found in colon blood vessels.
database_cross_reference: CALOHA:TS-2397
has related synonym: colon endothelial cells
has related synonym: colonic endothelial cell
id: CL:1001572

nasopharyngeal epithelial cell
type: Class
equivalent class: Class
  intersection of: epithelial cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0001728
subclass of: epithelial cell of alimentary canal
subclass of: epithelial cell of upper respiratory tract
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0001728
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0001951
IAO_0000115: Cell of the nasopharyngeal epithelium.
database_cross_reference: CALOHA:TS-2398
has related synonym: nasopharynx respiratory epithelial cells
id: CL:1001573

uterine cervix squamous cell
type: Class
equivalent class: Class
  intersection of: squamous epithelial cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0000002
subclass of: squamous epithelial cell
subclass of: epithelial cell of cervix
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0000002
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0004801
IAO_0000115: Squamous cell of uterine cervix epithelium.
database_cross_reference: CALOHA:TS-1251
has related synonym: cervix squamous cell
has related synonym: cervix squamous epithelial cell
has related synonym: cervix, uterine squamous epithelial cells
has related synonym: uterine cervix squamous epithelial cell
has related synonym: uterine cervix squamous epithelial cells
id: CL:1001575

oral mucosa squamous cell
type: Class
equivalent class: Class
  intersection of: squamous epithelial cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0002424
subclass of: squamous epithelial cell
subclass of: epithelial cell of alimentary canal
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0002424
IAO_0000115: Squamous cell of oral epithelium.
database_cross_reference: CALOHA:TS-1252
has related synonym: oral cavity mucosa squamous cell
has related synonym: oral cavity mucosa squamous epithelial cell
has related synonym: oral mucosa squamous epithelial cell
has related synonym: oral mucosa squamous epithelial cells
id: CL:1001576

vagina squamous cell
type: Class
equivalent class: Class
  intersection of: squamous epithelial cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0000996
subclass of: BFO_0000004
subclass of: squamous epithelial cell
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0000996
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0001344
IAO_0000115: Squamous cell of vaginal epithelium.
database_cross_reference: CALOHA:TS-1254
has related synonym: vagina squamous epithelial cell
has related synonym: vagina squamous epithelial cells
has related synonym: vaginal squamous cell
has related synonym: vaginal squamous epithelial cell
id: CL:1001578

cerebral cortex glial cell
type: Class
equivalent class: Class
  intersection of: glial cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0000956
subclass of: glial cell
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0000956
IAO_0000115: Glial cell of cerebral cortex.
database_cross_reference: CALOHA:TS-1256
has related synonym: brain cortex glial cell
has related synonym: cerebral cortex glial cells
has related synonym: cerebrum cortex glial cell
id: CL:1001579

lateral ventricle glial cell
type: Class
equivalent class: Class
  intersection of: glial cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0002285
subclass of: glial cell
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0002285
IAO_0000115: Glial cell of lateral ventricle.
database_cross_reference: CALOHA:TS-1258
has related synonym: lateral ventricle glial cells
id: CL:1001581

lateral ventricle neuron
type: Class
equivalent class: Class
  intersection of: neuron
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0002285
subclass of: central nervous system neuron
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0002285
IAO_0000115: Neuron of lateral ventricle.
database_cross_reference: CALOHA:TS-1261
has related synonym: lateral ventricle neural cell
has related synonym: lateral ventricle neuronal cell
has related synonym: lateral ventricle neuronal cells
id: CL:1001582

appendix glandular cell
type: Class
equivalent class: Class
  intersection of: glandular epithelial cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0001154
subclass of: epithelial cell of appendix
subclass of: colon glandular cell
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0001154
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0009697
IAO_0000115: Glandular cell of appendix epithelium. Example: Goblet cells; enterocytes or absorptive cells; enteroendocrine and M cells.
database_cross_reference: CALOHA:TS-1271
has related synonym: appendix glandular cells
has related synonym: caecal appendix glandular cell
has related synonym: cecal appendix glandular cell
has related synonym: vermiform appendix glandular cell
id: CL:1001585

mammary gland glandular cell
type: Class
equivalent class: Class
  intersection of: glandular epithelial cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0001911
subclass of: glandular epithelial cell
subclass of: exocrine cell
subclass of: mammary gland epithelial cell
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0001911
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0003244
IAO_0000115: Glandular cell of mammary epithelium. Example: glandular cells of large and intermediate ducts, glandular cells in terminal ducts.
database_cross_reference: CALOHA:TS-1272
has related synonym: breast glandular cell
has related synonym: breast glandular cells
has related synonym: mammary glandular cell
id: CL:1001586

uterine cervix glandular cell
type: Class
equivalent class: Class
  intersection of: glandular epithelial cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0000002
subclass of: epithelial cell of cervix
subclass of: oviduct glandular cell
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0000002
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0004801
IAO_0000115: Glandular cell of uterine cervix epithelium.
database_cross_reference: CALOHA:TS-1273
has related synonym: cervix glandular cell
has related synonym: cervix, uterine glandular cell
has related synonym: cervix, uterine glandular cells
id: CL:1001587

colon glandular cell
type: Class
equivalent class: Class
  intersection of: glandular epithelial cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0001155
subclass of: glandular cell of the large intestine
subclass of: colon epithelial cell
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0000397
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0001155
IAO_0000115: Glandular cell of colon epithelium. Example: Goblet cells; enterocytes or absorptive cells; enteroendocrine and M cells.
database_cross_reference: CALOHA:TS-1274
has related synonym: colon glandular cells
id: CL:1001588

duodenum glandular cell
type: Class
equivalent class: Class
  intersection of: glandular epithelial cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0002114
subclass of: small intestine glandular cell
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0002114
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0008346
IAO_0000115: Glandular cell of duodenal epithelium. Example: Enterocytes, Goblet cells, enteroendocrine cells; Paneth cells; M cells; Brunner's gland cell.
database_cross_reference: CALOHA:TS-1275
has related synonym: duodenum glandular cells
id: CL:1001589

epididymis glandular cell
type: Class
equivalent class: Class
  intersection of: glandular epithelial cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0001301
subclass of: duct epithelial cell
subclass of: glandular epithelial cell
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0001301
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0004544
IAO_0000115: Glandular cell of epididymal epithelium.
database_cross_reference: CALOHA:TS-1276
has related synonym: epididymal glandular cell
has related synonym: epididymis glandular cells
id: CL:1001590

oviduct glandular cell
type: Class
equivalent class: Class
  intersection of: glandular epithelial cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0000993
subclass of: glandular epithelial cell
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0000993
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0004804
IAO_0000115: Glandular cell of oviduct epithelium. Example: peg cells, ciliated cells.
database_cross_reference: CALOHA:TS-1277
has related synonym: fallopian tube glandular cell
has related synonym: fallopian tube glandular cells
has related synonym: uterine tube glandular cell
id: CL:1001591

gall bladder glandular cell
type: Class
equivalent class: Class
  intersection of: glandular epithelial cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0002110
subclass of: glandular epithelial cell
subclass of: epithelial cell of gall bladder
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0002029
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0002110
IAO_0000115: Glandular cell of gall bladder epithelium.
database_cross_reference: CALOHA:TS-1278
has related synonym: gall bladder glandular cells
has related synonym: gallbladder glandular cell
has related synonym: gallbladder glandular cells
id: CL:1001592

parathyroid glandular cell
type: Class
equivalent class: Class
  intersection of: glandular epithelial cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0001132
subclass of: glandular epithelial cell
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0001132
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0011197
IAO_0000115: Glandular cell of parathyroid epithelium. Example: Parathyroid chief cell and parathyroid oxyphil cells.
database_cross_reference: CALOHA:TS-1279
has related synonym: parathyroid gland glandular cell
has related synonym: parathyroid gland glandular cells
id: CL:1001593

rectum glandular cell
type: Class
equivalent class: Class
  intersection of: glandular epithelial cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0001052
subclass of: glandular cell of the large intestine
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0001052
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0003354
IAO_0000115: Glandular cell of rectal epithelium. Example: Goblet cell; enterocytes or absorptive cells; enteroendocrine and M cells.
database_cross_reference: CALOHA:TS-1281
has related synonym: rectal glandular cell
has related synonym: rectum glandular cells
id: CL:1001595

salivary gland glandular cell
type: Class
equivalent class: Class
  intersection of: glandular epithelial cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0001044
subclass of: glandular epithelial cell
subclass of: exocrine cell
subclass of: epithelial cell of alimentary canal
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0001044
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0004809
IAO_0000115: Glandular cell of salivary gland. Example: Serous cells, mucous cells, cuboidal epithelial cells of the intercalated ducts, simple cuboidal epithelium of the striated ducts, epithelial cells of excretory ducts.
database_cross_reference: CALOHA:TS-1282
has related synonym: salivary gland glandular cells
id: CL:1001596

seminal vesicle glandular cell
type: Class
equivalent class: Class
  intersection of: glandular epithelial cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0000998
subclass of: duct epithelial cell
subclass of: glandular epithelial cell
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0000998
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0004805
IAO_0000115: Glandular cell of seminal vesicle epithelium.
database_cross_reference: CALOHA:TS-1283
has related synonym: seminal vesicle glandular cells
id: CL:1001597

small intestine glandular cell
type: Class
equivalent class: Class
  intersection of: glandular epithelial cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0002108
subclass of: glandular epithelial cell
subclass of: epithelial cell of small intestine
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0001902
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0002108
IAO_0000115: A glandular cell found in the epithelium of the small intestine. Example: Enterocytes, Goblet cells, enteroendocrine cells; Paneth cells; M cells; Somatostatin-secreting Cells (D-cells) .
database_cross_reference: CALOHA:TS-1286
database_cross_reference: FMA:86928
has related synonym: small bowel glandular cell
has related synonym: small intestinal glandular cell
has related synonym: small intestine glandular cells
id: CL:1001598

pancreas exocrine glandular cell
type: Class
equivalent class: Class
  intersection of: glandular epithelial cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0000017
subclass of: glandular epithelial cell
subclass of: exocrine cell
subclass of: epithelial cell of exocrine pancreas
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0000017
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0013697
IAO_0000115: Glandular cell of exocrine pancreas epithelium. Example: pancreatic acinar cell, glandular cells in pancreatic canaliculi, glandular cells in pancreatic ducts.
database_cross_reference: BTO:0000028
database_cross_reference: CALOHA:TS-1242
has related synonym: exocrine pancreas glandular cell
has related synonym: pancreas exocrine glandular cells
id: CL:1001599

adrenal gland glandular cell
type: Class
equivalent class: Class
  intersection of: glandular epithelial cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0001235
subclass of: glandular epithelial cell
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0001235
IAO_0000115: Hormone secreting cell located in the cortex of adrenal gland. Glandular cells in the adrenal cortex secrete mineralocorticoids, glucocorticoids and androgens.
database_cross_reference: CALOHA:TS-2177
has related synonym: adrenal gland glandular cells
has related synonym: adrenal glandular cell
has related synonym: suprarenal gland glandular cell
id: CL:1001601

cerebral cortex endothelial cell
type: Class
equivalent class: Class
  intersection of: endothelial cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0000956
subclass of: endothelial cell
subclass of: neural cell
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0000956
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0013694
IAO_0000115: Endothelial cells forming the walls of the capillaries within the cerebral cortex.
database_cross_reference: CALOHA:TS-2372
has related synonym: cerebral cortex endothelial cells
has related synonym: endothelial cells of cerebral cortex
id: CL:1001602

lung macrophage
type: Class
equivalent class: Class
  intersection of: macrophage
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0002048
subclass of: macrophage
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0002048
IAO_0000115: Circulating macrophages and tissue macrophages (alveolar macrophages) of lung.
database_cross_reference: CALOHA:TS-0576
has related synonym: lung macrophages
id: CL:1001603

muscle fibroblast
type: Class
equivalent class: Class
  intersection of: fibroblast
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0001630
subclass of: fibroblast
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0001630
IAO_0000115: Fibroblast from muscle organ.
database_cross_reference: CALOHA:TS-0643
id: CL:1001609

bone marrow hematopoietic cell
type: Class
equivalent class: Class
  intersection of: hematopoietic cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0002371
subclass of: hematopoietic cell
subclass of: bone marrow cell
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0002371
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0012429
IAO_0000115: Hematopoietic cells resident in the bone marrow. Include: hematopoietic stem cells (lymphoid stem cells and myeloid stem cells) and the precursor cells for thrombocytes, erythrocytes, basophils, neutrophils, eosinophils, monocytes and lymphocytes.
database_cross_reference: CALOHA:TS-2109
has related synonym: bone marrow hematopoietic cells
has related synonym: bone marrow poietic cells
id: CL:1001610

cerebellar neuron
type: Class
equivalent class: Class
  intersection of: neuron
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0002037
subclass of: central nervous system neuron
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0002037
IAO_0000115: Neuron of the cerebellum.
database_cross_reference: CALOHA:TS-2359
database_cross_reference: FMA:84665
has related synonym: cerebellum neuron
id: CL:1001611

epidermal melanocyte
type: Class
equivalent class: Class
  intersection of: melanocyte
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0001003
subclass of: epithelial melanocyte
subclass of: melanocyte of skin
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0001003
IAO_0000115: Any melanocyte that is part of a epidermis.
created by: TermGenie
creation date: 2014-02-03T23:03:09Z
has OBO namespace: cell
id: CL:2000000
comment: These cells are found primarily, but not exclusively, in primates including humans

peripheral blood mononuclear cell
type: Class
equivalent class: Class
  intersection of: mononuclear cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0000178
subclass of: circulating cell
subclass of: mononuclear cell
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0000178
IAO_0000115: A leukocyte with a single non-segmented nucleus in the mature form found in the circulatory pool of blood.
created by: TermGenie
creation date: 2014-02-11T17:29:04Z
has OBO namespace: cell
id: CL:2000001

pituitary gland cell
type: Class
equivalent class: Class
  intersection of: native cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0000007
subclass of: neural cell
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0000007
IAO_0000115: Any cell that is part of a pituitary gland.
created by: TermGenie
creation date: 2014-03-26T22:14:56Z
has OBO namespace: cell
id: CL:2000004

brain macroglial cell
type: Class
equivalent class: Class
  intersection of: macroglial cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0000955
subclass of: macroglial cell
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0000955
IAO_0000115: Any macroglial cell that is part of a brain.
created by: TermGenie
creation date: 2014-03-28T21:35:27Z
has OBO namespace: cell
id: CL:2000005

dermis blood vessel endothelial cell
type: Class
equivalent class: Class
  intersection of: blood vessel endothelial cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0002067
subclass of: blood vessel endothelial cell
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0002067
IAO_0000115: Any blood vessel endothelial cell that is part of a dermis.
created by: TermGenie
creation date: 2014-06-04T15:12:06Z
has OBO namespace: cell
id: CL:2000010

dermis lymphatic vessel endothelial cell
type: Class
equivalent class: Class
  intersection of: endothelial cell of lymphatic vessel
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0002067
subclass of: endothelial cell of lymphatic vessel
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0002067
IAO_0000115: Any endothelial cell of lymphatic vessel that is part of a dermis.
created by: TermGenie
creation date: 2014-06-04T15:15:08Z
has OBO namespace: cell
id: CL:2000011

fibroblast of skin of abdomen
type: Class
equivalent class: Class
  intersection of: skin fibroblast
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0001416
subclass of: skin fibroblast
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0001416
IAO_0000115: Any skin fibroblast that is part of a skin of abdomen.
created by: TermGenie
creation date: 2014-06-04T15:18:16Z
has OBO namespace: cell
id: CL:2000013

fibroblast of upper leg skin
type: Class
equivalent class: Class
  intersection of: skin fibroblast
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0004262
subclass of: skin fibroblast
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0004262
IAO_0000115: Any skin fibroblast that is part of a upper leg skin.
created by: TermGenie
creation date: 2014-06-04T15:19:44Z
has OBO namespace: cell
id: CL:2000014

fibroblast of arm
type: Class
equivalent class: Class
  intersection of: skin fibroblast
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0001460
subclass of: skin fibroblast
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0001460
IAO_0000115: Any skin fibroblast that is part of a arm.
created by: TermGenie
creation date: 2014-06-04T15:29:06Z
has OBO namespace: cell
id: CL:2000015

fibroblast of peridontal ligament
type: Class
equivalent class: Class
  intersection of: fibroblast
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0008266
subclass of: fibroblast of periodontium
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0008266
IAO_0000115: Any fibroblast that is part of a periodontal ligament.
created by: TermGenie
creation date: 2014-06-04T16:50:33Z
has OBO namespace: cell
id: CL:2000017

inner cell mass native cell
type: Class
equivalent class: Class
  intersection of: native cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0000087
subclass of: BFO_0000004
subclass of: native cell
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0000087
IAO_0000115: Any native cell that is part of a inner cell mass.
created by: TermGenie
creation date: 2014-06-24T23:16:53Z
has OBO namespace: cell
id: CL:2000020

sebaceous gland native cell
type: Class
equivalent class: Class
  intersection of: native cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0001821
subclass of: BFO_0000004
subclass of: native cell
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0001821
IAO_0000115: Any native cell that is part of a sebaceous gland.
created by: TermGenie
creation date: 2014-06-24T23:17:00Z
has OBO namespace: cell
id: CL:2000021

cardiac septum native cell
type: Class
equivalent class: Class
  intersection of: native cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0002099
subclass of: BFO_0000004
subclass of: native cell
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0002099
IAO_0000115: Any native cell that is part of a cardiac septum.
created by: TermGenie
creation date: 2014-06-24T23:17:07Z
has OBO namespace: cell
id: CL:2000022

spinal cord oligodendrocyte
type: Class
equivalent class: Class
  intersection of: oligodendrocyte
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0002240
subclass of: oligodendrocyte
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0002240
IAO_0000115: Any oligodendrocyte that is part of a spinal cord.
created by: TermGenie
creation date: 2014-06-25T00:23:50Z
has OBO namespace: cell
id: CL:2000025

central nervous system neuron
type: Class
equivalent class: Class
  intersection of: neuron
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0001017
subclass of: neuron
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0001017
IAO_0000115: Any neuron that is part of a central nervous system.
created by: TermGenie
creation date: 2014-06-25T01:17:43Z
has OBO namespace: cell
id: CL:2000029

peripheral nervous system neuron
type: Class
equivalent class: Class
  intersection of: neuron
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0000010
subclass of: neuron
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0000010
IAO_0000115: Any neuron that is part of a peripheral nervous system.
created by: TermGenie
creation date: 2014-06-25T02:28:17Z
has OBO namespace: cell
id: CL:2000032

limb basal cell of epidermis
type: Class
equivalent class: Class
  intersection of: basal cell of epidermis
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0002101
subclass of: basal cell of epidermis
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0002101
IAO_0000115: Any basal cell of epidermis that is part of a limb.
created by: TermGenie
creation date: 2014-06-25T02:28:25Z
has OBO namespace: cell
id: CL:2000033

embryonic fibroblast
type: Class
equivalent class: Class
  intersection of: fibroblast
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0000922
subclass of: fibroblast
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0000922
IAO_0000115: Any fibroblast that is part of a embryo.
created by: TermGenie
creation date: 2014-07-09T00:12:00Z
has OBO namespace: cell
id: CL:2000042

brain pericyte
type: Class
equivalent class: Class
  intersection of: pericyte cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0000955
subclass of: central nervous system pericyte
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0000955
IAO_0000115: Any pericyte cell that is part of a brain.
created by: TermGenie
creation date: 2014-07-09T00:18:22Z
has OBO namespace: cell
id: CL:2000043

ventricular cardiac muscle cell
type: Class
equivalent class: Class
  intersection of: cardiac muscle cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0002082
subclass of: cardiac muscle cell
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0002082
IAO_0000115: Any cardiac muscle cell that is part of a cardiac ventricle.
created by: TermGenie
creation date: 2014-08-12T20:50:28Z
has OBO namespace: cell
id: CL:2000046

brainstem motor neuron
type: Class
equivalent class: Class
  intersection of: motor neuron
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0002298
subclass of: motor neuron
subclass of: central nervous system neuron
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0002298
IAO_0000115: Any motor neuron that is part of a brainstem.
created by: TermGenie
creation date: 2014-10-02T23:52:53Z
has OBO namespace: cell
id: CL:2000047

splenic fibroblast
type: Class
equivalent class: Class
  intersection of: fibroblast
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0002106
subclass of: fibroblast
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0002106
IAO_0000115: Any fibroblast that is part of a spleen.
created by: TermGenie
creation date: 2014-10-06T18:58:47Z
has OBO namespace: cell
id: CL:2000051

umbilical artery endothelial cell
type: Class
equivalent class: Class
  intersection of: endothelial cell of artery
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0002331
subclass of: extraembryonic cell
subclass of: endothelial cell of artery
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0002331
IAO_0000115: Any endothelial cell of artery that is part of a umbilical cord.
created by: TermGenie
creation date: 2014-10-06T19:01:48Z
has OBO namespace: cell
id: CL:2000052
comment: http://www.sciencellonline.com/site/productInformation.php

splenic endothelial cell
type: Class
equivalent class: Class
  intersection of: endothelial cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0002106
subclass of: endothelial cell
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0002106
IAO_0000115: Any endothelial cell that is part of a spleen.
created by: TermGenie
creation date: 2014-10-06T19:06:04Z
has OBO namespace: cell
id: CL:2000053
comment: http://www.sciencellonline.com/site/productInformation.php

liver dendritic cell
type: Class
equivalent class: Class
  intersection of: dendritic cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0002107
subclass of: dendritic cell
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0002107
IAO_0000115: Any dendritic cell that is part of a liver.
created by: TermGenie
creation date: 2014-10-06T19:16:11Z
has OBO namespace: cell
id: CL:2000055
comment: http://www.jleukbio.org/content/66/2/322.abstract

femural osteoblast
type: Class
equivalent class: Class
  intersection of: osteoblast
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0000981
subclass of: osteoblast
subclass of: bone cell
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0000981
IAO_0000115: Any osteoblast that is part of a femur.
created by: TermGenie
creation date: 2014-10-06T19:29:45Z
has OBO namespace: cell
id: CL:2000057
comment: http://www.sciencellonline.com/site/productInformation.php

calvarial osteoblast
type: Class
equivalent class: Class
  intersection of: osteoblast
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0003129
subclass of: osteoblast
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0003129
IAO_0000115: Any osteoblast that is part of a skull.
created by: TermGenie
creation date: 2014-10-06T19:48:30Z
has OBO namespace: cell
id: CL:2000058
comment: http://www.sciencellonline.com/site/productInformation.php

placental villous trophoblast
type: Class
equivalent class: Class
  intersection of: trophoblast cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0001987
subclass of: trophoblast cell
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0001987
IAO_0000115: Any trophoblast cell that is part of a placenta.
created by: TermGenie
creation date: 2014-10-07T17:48:27Z
has OBO namespace: cell
id: CL:2000060
comment: http://www.sciencellonline.com/site/productInformation.php

placental amniotic mesenchymal stromal cell
type: Class
equivalent class: Class
  intersection of: mesenchymal stem cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0001987
subclass of: mesenchymal stem cell
subclass of: extraembryonic cell
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0001987
IAO_0000115: Any mesenchymal stem cell that is part of a placenta.
created by: TermGenie
creation date: 2014-10-07T17:51:11Z
has OBO namespace: cell
id: CL:2000061
comment: http://www.sciencellonline.com/site/productInformation.php

placental villus capillary endothelial cell
type: Class
equivalent class: Class
  intersection of: capillary endothelial cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0001987
subclass of: capillary endothelial cell
subclass of: placental epithelial cell
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0001987
IAO_0000115: Any capillary endothelial cell that is part of a placenta.
created by: TermGenie
creation date: 2014-10-07T17:55:56Z
has OBO namespace: cell
id: CL:2000062
comment: http://www.ncbi.nlm.nih.gov/books/NBK53245/

ovarian fibroblast
type: Class
equivalent class: Class
  intersection of: fibroblast
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0000992
subclass of: fibroblast
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0000992
IAO_0000115: Any fibroblast that is part of a female gonad.
created by: TermGenie
creation date: 2014-10-07T17:57:42Z
has OBO namespace: cell
id: CL:2000063
comment: http://www.sciencellonline.com/site/productInformation.php

ovarian surface epithelial cell
type: Class
equivalent class: Class
  intersection of: epithelial cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0000992
subclass of: BFO_0000004
subclass of: epithelial cell
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0000992
IAO_0000115: Any epithelial cell that is part of a female gonad.
created by: TermGenie
creation date: 2014-10-07T17:59:13Z
has OBO namespace: cell
id: CL:2000064
comment: http://www.sciencellonline.com/site/productInformation.php

cardiac ventricle fibroblast
type: Class
equivalent class: Class
  intersection of: fibroblast
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0002082
subclass of: fibroblast of cardiac tissue
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0002082
IAO_0000115: Any fibroblast that is part of a cardiac ventricle.
created by: TermGenie
creation date: 2014-10-07T18:35:38Z
has OBO namespace: cell
id: CL:2000066
comment: http://www.sciencellonline.com/site/productInformation.php

cardiac atrium fibroblast
type: Class
equivalent class: Class
  intersection of: fibroblast
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0002081
subclass of: fibroblast of cardiac tissue
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0002081
IAO_0000115: Any fibroblast that is part of a cardiac atrium.
created by: TermGenie
creation date: 2014-10-07T18:36:54Z
has OBO namespace: cell
id: CL:2000067
comment: http://www.sciencellonline.com/site/productInformation.php

pericardium fibroblast
type: Class
equivalent class: Class
  intersection of: fibroblast
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0002407
subclass of: fibroblast
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0002407
IAO_0000115: Any fibroblast that is part of a pericardium.
created by: TermGenie
creation date: 2014-10-07T18:38:06Z
has OBO namespace: cell
id: CL:2000068
comment: http://www.sciencellonline.com/site/productInformation.php

gallbladder fibroblast
type: Class
equivalent class: Class
  intersection of: fibroblast
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0002110
subclass of: fibroblast
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0002110
IAO_0000115: Any fibroblast that is part of a gallbladder.
created by: TermGenie
creation date: 2014-10-07T18:41:43Z
has OBO namespace: cell
id: CL:2000069
comment: http://www.sciencellonline.com/site/productInformation.php

optic choroid fibroblast
type: Class
equivalent class: Class
  intersection of: fibroblast
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0001776
subclass of: fibroblast
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0001776
IAO_0000115: Any fibroblast that is part of a optic choroid.
created by: TermGenie
creation date: 2014-10-07T18:50:43Z
has OBO namespace: cell
id: CL:2000070
comment: http://www.sciencellonline.com/site/productInformation.php

migratory cardiac neural crest cell
type: Class
equivalent class: Class
  intersection of: migratory neural crest cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0000095
subclass of: migratory neural crest cell
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0000095
IAO_0000115: Any migratory neural crest cell that is part of a cardiac neural crest.
created by: TermGenie
creation date: 2014-11-05T01:18:43Z
has OBO namespace: cell
id: CL:2000073

splenocyte
type: Class
equivalent class: Class
  intersection of: leukocyte
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0002106
subclass of: leukocyte
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0002106
IAO_0000115: Any leukocyte that is part of a spleen.
created by: TermGenie
creation date: 2014-11-05T01:26:50Z
has OBO namespace: cell
id: CL:2000074
comment: Splenocytes is a vague term that refers to any one of the different white blood cell types in the spleen. This name is seen many references as such and is not explained further, necessitating a need for this terminology.

hindlimb stylopod vein endothelial cell
type: Class
equivalent class: Class
  intersection of: vein endothelial cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0000376
subclass of: vein endothelial cell
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0000376
IAO_0000115: Any vein endothelial cell that is part of a hindlimb stylopod.
created by: TermGenie
creation date: 2014-12-02T18:40:47Z
has OBO namespace: cell
id: CL:2000076

placental pericyte
type: Class
equivalent class: Class
  intersection of: pericyte cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0001987
subclass of: extraembryonic cell
subclass of: pericyte cell
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0001987
IAO_0000115: Any pericyte cell that is part of a placenta.
created by: TermGenie
creation date: 2014-12-02T18:51:03Z
has OBO namespace: cell
id: CL:2000078

mesenchymal stem cell of femoral bone marrow
type: Class
equivalent class: Class
  intersection of: mesenchymal stem cell of the bone marrow
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0000981
subclass of: mesenchymal stem cell of the bone marrow
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0000981
IAO_0000115: Any mesenchymal stem cell of the bone marrow that is part of a femur.
created by: TermGenie
creation date: 2014-12-02T19:07:31Z
has OBO namespace: cell
id: CL:2000079

mesenchymal stem cell of abdominal adipose
type: Class
equivalent class: Class
  intersection of: mesenchymal stem cell of adipose
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0000916
subclass of: mesenchymal stem cell of adipose
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0000916
IAO_0000115: Any mesenchymal stem cell of adipose that is part of a abdomen.
created by: TermGenie
creation date: 2014-12-02T19:10:34Z
has OBO namespace: cell
id: CL:2000080

melanocyte of skin of face
type: Class
equivalent class: Class
  intersection of: melanocyte of skin
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_1000021
subclass of: melanocyte of skin
subclass of: Restriction
  on property: part_of
  some values from: UBERON_1000021
IAO_0000115: Any melanocyte of skin that is part of a skin of face.
created by: TermGenie
creation date: 2014-12-02T19:10:40Z
has OBO namespace: cell
id: CL:2000081

mononuclear cell of umbilical cord
type: Class
equivalent class: Class
  intersection of: mononuclear cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0002331
subclass of: extraembryonic cell
subclass of: mononuclear cell
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0002331
IAO_0000115: Any mononuclear cell that is part of a umbilical cord.
created by: TermGenie
creation date: 2014-12-02T20:14:16Z
has OBO namespace: cell
id: CL:2000085

hair follicular keratinocyte
type: Class
equivalent class: Class
  intersection of: keratinocyte
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0002073
subclass of: keratinocyte
subclass of: hair follicle cell
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0002073
IAO_0000115: Any keratinocyte that is part of a hair follicle.
created by: TermGenie
creation date: 2015-03-31T21:07:02Z
has OBO namespace: cell
id: CL:2000092

bronchus fibroblast of lung
type: Class
equivalent class: Class
  intersection of: fibroblast of lung
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0002185
subclass of: fibroblast of lung
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0002185
IAO_0000115: Any fibroblast of lung that is part of a bronchus.
created by: TermGenie
creation date: 2015-03-31T21:16:22Z
has OBO namespace: cell
id: CL:2000093

cord blood hematopoietic stem cell
type: Class
equivalent class: Class
  intersection of: hematopoietic stem cell
  intersection of: Restriction
    on property: part_of
    some values from: UBERON_0012168
subclass of: peripheral blood stem cell
subclass of: gestational hematopoietic stem cell
subclass of: Restriction
  on property: part_of
  some values from: UBERON_0012168
IAO_0000115: Any hematopoietic stem cell that is part of a umbilical cord blood.
created by: TermGenie
creation date: 2015-05-26T18:58:34Z
has OBO namespace: cell
id: CL:2000095

biome
type: Class
subclass of: environmental system

terrestrial biome
type: Class
subclass of: biome

environmental system
type: Class

reproduction
type: Class
subclass of: biological_process

polysaccharide biosynthetic process
type: Class
subclass of: polysaccharide metabolic process
subclass of: macromolecule biosynthetic process
subclass of: carbohydrate biosynthetic process

polysaccharide catabolic process
type: Class
subclass of: polysaccharide metabolic process
subclass of: macromolecule catabolic process
subclass of: carbohydrate catabolic process

skeletal system development
type: Class
subclass of: system development

ossification
type: Class
subclass of: multicellular organismal process

angiogenesis
type: Class
subclass of: anatomical structure formation involved in morphogenesis
subclass of: Restriction
  on property: part_of
  some values from: blood vessel morphogenesis

blood vessel development
type: Class
subclass of: anatomical structure development
subclass of: Restriction
  on property: part_of
  some values from: vasculature development

branching involved in blood vessel morphogenesis
type: Class
equivalent class: Class
  intersection of: branching morphogenesis of an epithelial tube
  intersection of: Restriction
    on property: part_of
    some values from: blood vessel morphogenesis
subclass of: branching morphogenesis of an epithelial tube
subclass of: Restriction
  on property: part_of
  some values from: angiogenesis

temperature homeostasis
type: Class
subclass of: multicellular organismal homeostasis

ameboidal-type cell migration
type: Class
subclass of: cell migration

gastric acid secretion
type: Class
subclass of: digestive system process
subclass of: acid secretion

formation of primary germ layer
type: Class
subclass of: anatomical structure formation involved in morphogenesis
subclass of: Restriction
  on property: part_of
  some values from: gastrulation

ectoderm formation
type: Class
subclass of: formation of primary germ layer
subclass of: Restriction
  on property: part_of
  some values from: ectoderm development

endoderm formation
type: Class
subclass of: formation of primary germ layer
subclass of: Restriction
  on property: part_of
  some values from: endoderm development

mesoderm formation
type: Class
subclass of: formation of primary germ layer
subclass of: Restriction
  on property: part_of
  some values from: mesoderm morphogenesis

morphogenesis of a branching structure
type: Class
subclass of: anatomical structure morphogenesis
subclass of: multicellular organismal process

cell activation
type: Class
subclass of: cellular process

serotonin secretion
type: Class
subclass of: serotonin transport
subclass of: secretion by cell

embryonic epithelial tube formation
type: Class
subclass of: GO_0072175
subclass of: Restriction
  on property: part_of
  some values from: morphogenesis of embryonic epithelium

neural tube formation
type: Class
subclass of: embryonic epithelial tube formation
subclass of: Restriction
  on property: part_of
  some values from: neural tube development

vasculature development
type: Class
subclass of: system development
subclass of: Restriction
  on property: part_of
  some values from: GO_0072358

intramembranous ossification
type: Class
subclass of: direct ossification

neurological system process involved in regulation of systemic arterial blood pressure
type: Class
equivalent class: Class
  intersection of: GO_0050877
  intersection of: Restriction
    on property: part_of
    some values from: regulation of systemic arterial blood pressure
subclass of: GO_0050877
subclass of: Restriction
  on property: part_of
  some values from: regulation of systemic arterial blood pressure

regulation of systemic arterial blood pressure by hormone
type: Class
subclass of: regulation of systemic arterial blood pressure mediated by a chemical signal
subclass of: GO_0050886

regulation of systemic arterial blood pressure by vasopressin
type: Class
subclass of: regulation of systemic arterial blood pressure by hormone

morphogenesis of an epithelium
type: Class
subclass of: tissue morphogenesis
subclass of: Restriction
  on property: part_of
  some values from: GO_0060429

regulation of heart rate
type: Class
subclass of: regulation of heart contraction
subclass of: GO_0065008

positive regulation of mesenchymal cell proliferation
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: positively regulates
    some values from: mesenchymal cell proliferation
subclass of: positive regulation of cell proliferation
subclass of: regulation of mesenchymal cell proliferation
subclass of: Restriction
  on property: positively regulates
  some values from: mesenchymal cell proliferation

regulation of respiratory gaseous exchange by neurological system process
type: Class
equivalent class: Class
  intersection of: GO_0050877
  intersection of: Restriction
    on property: regulates
    some values from: respiratory gaseous exchange
subclass of: regulation of respiratory system process
subclass of: GO_0050877

organ or tissue specific immune response
type: Class
subclass of: immune response

immune effector process
type: Class
subclass of: immune system process

cell activation involved in immune response
type: Class
equivalent class: Class
  intersection of: cell activation
  intersection of: Restriction
    on property: part_of
    some values from: immune response
subclass of: cell activation
subclass of: immune effector process
subclass of: Restriction
  on property: part_of
  some values from: immune response

lymphocyte activation involved in immune response
type: Class
equivalent class: Class
  intersection of: lymphocyte activation
  intersection of: Restriction
    on property: part_of
    some values from: immune response
subclass of: leukocyte activation involved in immune response
subclass of: lymphocyte activation

T cell activation involved in immune response
type: Class
equivalent class: Class
  intersection of: T cell activation
  intersection of: Restriction
    on property: part_of
    some values from: immune response
subclass of: lymphocyte activation involved in immune response
subclass of: T cell activation

T cell differentiation involved in immune response
type: Class
equivalent class: Class
  intersection of: T cell differentiation
  intersection of: Restriction
    on property: part_of
    some values from: immune response
subclass of: T cell activation involved in immune response
subclass of: T cell differentiation

B cell activation involved in immune response
type: Class
equivalent class: Class
  intersection of: B cell activation
  intersection of: Restriction
    on property: part_of
    some values from: immune response
subclass of: lymphocyte activation involved in immune response
subclass of: B cell activation

mature B cell differentiation involved in immune response
type: Class
equivalent class: Class
  intersection of: mature B cell differentiation
  intersection of: Restriction
    on property: part_of
    some values from: immune response
subclass of: B cell activation involved in immune response
subclass of: mature B cell differentiation

memory B cell differentiation
type: Class
subclass of: mature B cell differentiation involved in immune response
subclass of: GO_0090715

B cell proliferation involved in immune response
type: Class
equivalent class: Class
  intersection of: B cell proliferation
  intersection of: Restriction
    on property: part_of
    some values from: immune response
subclass of: B cell activation involved in immune response
subclass of: B cell proliferation

mature B cell differentiation
type: Class
subclass of: B cell differentiation

leukocyte activation involved in immune response
type: Class
equivalent class: Class
  intersection of: leukocyte activation
  intersection of: Restriction
    on property: part_of
    some values from: immune response
subclass of: cell activation involved in immune response
subclass of: leukocyte activation

immune system process
type: Class
subclass of: biological_process

hepatic immune response
type: Class
subclass of: organ or tissue specific immune response

immune system development
type: Class
subclass of: immune system process
subclass of: system development

leukocyte differentiation
type: Class
subclass of: cell differentiation
subclass of: Restriction
  on property: part_of
  some values from: hemopoiesis

regulation of immune system process
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: regulates
    some values from: immune system process
subclass of: regulation of biological process
subclass of: Restriction
  on property: regulates
  some values from: immune system process

negative regulation of immune system process
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: negatively regulates
    some values from: immune system process
subclass of: regulation of immune system process
subclass of: negative regulation of biological process
subclass of: Restriction
  on property: negatively regulates
  some values from: immune system process

positive regulation of immune system process
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: positively regulates
    some values from: immune system process
subclass of: regulation of immune system process
subclass of: positive regulation of biological process
subclass of: Restriction
  on property: positively regulates
  some values from: immune system process

regulation of leukocyte activation
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: regulates
    some values from: leukocyte activation
subclass of: regulation of immune system process
subclass of: GO_0050865
subclass of: Restriction
  on property: regulates
  some values from: leukocyte activation

negative regulation of leukocyte activation
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: negatively regulates
    some values from: leukocyte activation
subclass of: negative regulation of immune system process
subclass of: regulation of leukocyte activation
subclass of: GO_0050866
subclass of: Restriction
  on property: negatively regulates
  some values from: leukocyte activation

positive regulation of leukocyte activation
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: positively regulates
    some values from: leukocyte activation
subclass of: positive regulation of immune system process
subclass of: regulation of leukocyte activation
subclass of: GO_0050867
subclass of: Restriction
  on property: positively regulates
  some values from: leukocyte activation

regulation of immune effector process
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: regulates
    some values from: immune effector process
subclass of: regulation of immune system process
subclass of: Restriction
  on property: regulates
  some values from: immune effector process

negative regulation of immune effector process
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: negatively regulates
    some values from: immune effector process
subclass of: negative regulation of immune system process
subclass of: regulation of immune effector process
subclass of: Restriction
  on property: negatively regulates
  some values from: immune effector process

positive regulation of immune effector process
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: positively regulates
    some values from: immune effector process
subclass of: positive regulation of immune system process
subclass of: regulation of immune effector process
subclass of: Restriction
  on property: positively regulates
  some values from: immune effector process

peptide secretion
type: Class
subclass of: peptide transport
subclass of: secretion

regulation of peptide secretion
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: regulates
    some values from: peptide secretion
subclass of: GO_0051046
subclass of: GO_0090087
subclass of: Restriction
  on property: regulates
  some values from: peptide secretion

negative regulation of peptide secretion
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: negatively regulates
    some values from: peptide secretion
subclass of: regulation of peptide secretion
subclass of: GO_0051048
subclass of: Restriction
  on property: negatively regulates
  some values from: peptide secretion

positive regulation of peptide secretion
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: positively regulates
    some values from: peptide secretion
subclass of: regulation of peptide secretion
subclass of: GO_0051047
subclass of: Restriction
  on property: positively regulates
  some values from: peptide secretion

developmental process involved in reproduction
type: Class
equivalent class: Class
  intersection of: developmental process
  intersection of: Restriction
    on property: part_of
    some values from: reproduction
subclass of: reproductive process
subclass of: developmental process

system process
type: Class
subclass of: multicellular organismal process

muscle system process
type: Class
subclass of: system process

circulatory system process
type: Class
subclass of: system process

renal system process
type: Class
subclass of: system process

heart process
type: Class
subclass of: circulatory system process

respiratory system process
type: Class
subclass of: system process
subclass of: respiratory gaseous exchange

regulation of systemic arterial blood pressure mediated by a chemical signal
type: Class
subclass of: regulation of systemic arterial blood pressure

renal system process involved in regulation of systemic arterial blood pressure
type: Class
equivalent class: Class
  intersection of: renal system process
  intersection of: Restriction
    on property: part_of
    some values from: regulation of systemic arterial blood pressure
subclass of: renal system process
subclass of: Restriction
  on property: part_of
  some values from: regulation of systemic arterial blood pressure

regulation of systemic arterial blood pressure
type: Class
subclass of: regulation of blood pressure

renal water homeostasis
type: Class
subclass of: renal system process
subclass of: GO_0050891

renal water transport
type: Class
subclass of: renal system process
subclass of: water transport
subclass of: Restriction
  on property: part_of
  some values from: renal water homeostasis

regulation of extracellular matrix constituent secretion
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: regulates
    some values from: GO_0070278
subclass of: GO_1903053
subclass of: GO_1903530
subclass of: Restriction
  on property: regulates
  some values from: GO_0070278

positive regulation of extracellular matrix constituent secretion
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: positively regulates
    some values from: GO_0070278
subclass of: regulation of extracellular matrix constituent secretion
subclass of: GO_1903055
subclass of: GO_1903532
subclass of: Restriction
  on property: positively regulates
  some values from: GO_0070278

negative regulation of extracellular matrix constituent secretion
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: negatively regulates
    some values from: GO_0070278
subclass of: regulation of extracellular matrix constituent secretion
subclass of: GO_1903054
subclass of: GO_1903531
subclass of: Restriction
  on property: negatively regulates
  some values from: GO_0070278

molecular_function
type: Class

signal transducer activity
type: Class
equivalent class: Class
  intersection of: molecular_function
  intersection of: Restriction
    on property: part_of
    some values from: signal transduction
subclass of: BFO_0000003
subclass of: molecular_function
subclass of: Restriction
  on property: part_of
  some values from: signal transduction

receptor activity
type: Class
subclass of: GO_0060089

transmembrane signaling receptor activity
type: Class
equivalent class: Class
  intersection of: GO_0099600
  intersection of: Restriction
    on property: part_of
    some values from: signal transduction
subclass of: signaling receptor activity
subclass of: GO_0099600

cellular_component
type: Class

extracellular region
type: Class
subclass of: cellular_component

fibrinogen complex
type: Class
subclass of: protein complex
subclass of: extracellular region part
subclass of: Restriction
  on property: part_of
  some values from: extracellular space

proteinaceous extracellular matrix
type: Class
subclass of: extracellular matrix

collagen trimer
type: Class
subclass of: protein complex

fibrillar collagen trimer
type: Class
equivalent class: Class
  intersection of: collagen trimer
  intersection of: Restriction
    on property: part_of
    some values from: GO_0098643
subclass of: collagen trimer
subclass of: extracellular matrix component
subclass of: Restriction
  on property: part_of
  some values from: GO_0098643

collagen type II trimer
type: Class
subclass of: fibrillar collagen trimer

collagen type IV trimer
type: Class
subclass of: GO_0098642
subclass of: GO_0098651

basement membrane
type: Class
subclass of: extracellular matrix component
subclass of: Restriction
  on property: part_of
  some values from: proteinaceous extracellular matrix

extracellular space
type: Class
subclass of: extracellular region part

intracellular
type: Class
subclass of: cell part

cell
type: Class
subclass of: cellular_component

nucleus
type: Class
subclass of: intracellular membrane-bounded organelle

cytoplasm
type: Class
subclass of: intracellular part

cytoskeleton
type: Class
subclass of: intracellular non-membrane-bounded organelle

intermediate filament
type: Class
subclass of: GO_0099513
subclass of: Restriction
  on property: part_of
  some values from: intermediate filament cytoskeleton

actin filament
type: Class
subclass of: GO_0099513
subclass of: Restriction
  on property: part_of
  some values from: actin cytoskeleton

plasma membrane
type: Class
subclass of: membrane
subclass of: cell part
subclass of: Restriction
  on property: part_of
  some values from: GO_0071944

microvillus
type: Class
subclass of: GO_0098858
subclass of: Restriction
  on property: has_part
  some values from: actin filament bundle

cell-cell junction
type: Class
subclass of: cell junction

carbohydrate metabolic process
type: Class
subclass of: primary metabolic process
subclass of: GO_0071704

polysaccharide metabolic process
type: Class
subclass of: carbohydrate metabolic process
subclass of: macromolecule metabolic process

glycogen metabolic process
type: Class
subclass of: cellular glucan metabolic process
subclass of: energy reserve metabolic process

glycogen biosynthetic process
type: Class
subclass of: glycogen metabolic process
subclass of: glucan biosynthetic process

regulation of glycogen biosynthetic process
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: regulates
    some values from: glycogen biosynthetic process
subclass of: regulation of glucan biosynthetic process
subclass of: GO_0070873
subclass of: Restriction
  on property: regulates
  some values from: glycogen biosynthetic process

glycogen catabolic process
type: Class
subclass of: glycogen metabolic process
subclass of: glucan catabolic process
subclass of: cellular polysaccharide catabolic process

regulation of glycogen catabolic process
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: regulates
    some values from: glycogen catabolic process
subclass of: regulation of cellular carbohydrate catabolic process
subclass of: GO_0070873
subclass of: Restriction
  on property: regulates
  some values from: glycogen catabolic process

monosaccharide metabolic process
type: Class
subclass of: carbohydrate metabolic process
subclass of: small molecule metabolic process

glucose metabolic process
type: Class
subclass of: hexose metabolic process

cellular glucan metabolic process
type: Class
subclass of: glucan metabolic process
subclass of: cellular polysaccharide metabolic process

organic acid metabolic process
type: Class
subclass of: cellular metabolic process
subclass of: small molecule metabolic process
subclass of: GO_0071704

generation of precursor metabolites and energy
type: Class
subclass of: cellular metabolic process

regulation of carbohydrate metabolic process
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: regulates
    some values from: carbohydrate metabolic process
subclass of: GO_0080090
subclass of: Restriction
  on property: regulates
  some values from: carbohydrate metabolic process

energy reserve metabolic process
type: Class
subclass of: energy derivation by oxidation of organic compounds

cellular modified amino acid metabolic process
type: Class
subclass of: cellular metabolic process
subclass of: GO_1901564

thyroid hormone generation
type: Class
subclass of: thyroid hormone metabolic process

lipid metabolic process
type: Class
subclass of: primary metabolic process
subclass of: GO_0071704

steroid biosynthetic process
type: Class
subclass of: steroid metabolic process
subclass of: lipid biosynthetic process
subclass of: GO_1901362

bile acid biosynthetic process
type: Class
subclass of: steroid biosynthetic process
subclass of: bile acid metabolic process
subclass of: GO_0072330
subclass of: GO_1901617

glucocorticoid biosynthetic process
type: Class
subclass of: steroid biosynthetic process
subclass of: glucocorticoid metabolic process

mineralocorticoid biosynthetic process
type: Class
subclass of: steroid biosynthetic process
subclass of: mineralocorticoid metabolic process
subclass of: hormone biosynthetic process

cellular aromatic compound metabolic process
type: Class
subclass of: cellular metabolic process

nitrogen compound metabolic process
type: Class
subclass of: metabolic process

transport
type: Class
subclass of: GO_0051234

ion transport
type: Class
subclass of: transport

cation transport
type: Class
subclass of: ion transport

anion transport
type: Class
subclass of: ion transport

water transport
type: Class
subclass of: fluid transport

serotonin transport
type: Class
subclass of: ammonium transport
subclass of: monoamine transport
subclass of: organic hydroxy compound transport

lipid transport
type: Class
subclass of: GO_0071702
subclass of: Restriction
  on property: part_of
  some values from: lipid localization

exocytosis
type: Class
subclass of: vesicle-mediated transport
subclass of: secretion by cell
subclass of: Restriction
  on property: has_part
  some values from: GO_0099500

vesicle fusion
type: Class
subclass of: vesicle organization
subclass of: GO_0090174
subclass of: Restriction
  on property: part_of
  some values from: vesicle-mediated transport

movement of cell or subcellular component
type: Class
subclass of: cellular process

muscle contraction
type: Class
subclass of: muscle system process

regulation of muscle contraction
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: regulates
    some values from: muscle contraction
subclass of: GO_0090257
subclass of: Restriction
  on property: regulates
  some values from: muscle contraction

smooth muscle contraction
type: Class
subclass of: muscle contraction

regulation of smooth muscle contraction
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: regulates
    some values from: smooth muscle contraction
subclass of: regulation of muscle contraction
subclass of: Restriction
  on property: regulates
  some values from: smooth muscle contraction

striated muscle contraction
type: Class
subclass of: muscle contraction

regulation of striated muscle contraction
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: regulates
    some values from: striated muscle contraction
subclass of: regulation of muscle contraction
subclass of: Restriction
  on property: regulates
  some values from: striated muscle contraction

response to stress
type: Class
subclass of: GO_0050896

immune response
type: Class
subclass of: immune system process
subclass of: GO_0050896

organelle organization
type: Class
subclass of: cellular component organization

cell communication
type: Class
subclass of: cellular process

cell adhesion
type: Class
subclass of: biological adhesion

leukocyte cell-cell adhesion
type: Class
subclass of: GO_0098609

negative regulation of cell adhesion
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: negatively regulates
    some values from: cell adhesion
subclass of: regulation of cell adhesion
subclass of: negative regulation of cellular process
subclass of: Restriction
  on property: negatively regulates
  some values from: cell adhesion

signal transduction
type: Class
subclass of: cellular process
subclass of: regulation of cellular process
subclass of: Restriction
  on property: part_of
  some values from: cell communication
subclass of: Restriction
  on property: part_of
  some values from: signaling
subclass of: Restriction
  on property: part_of
  some values from: GO_0051716

cell-cell signaling
type: Class
subclass of: cell communication
subclass of: signaling

multicellular organism development
type: Class
subclass of: multicellular organismal process
subclass of: anatomical structure development

gamete generation
type: Class
subclass of: multicellular organismal reproductive process
subclass of: Restriction
  on property: part_of
  some values from: sexual reproduction

germ cell development
type: Class
subclass of: developmental process involved in reproduction
subclass of: cellular process involved in reproduction in multicellular organism
subclass of: cell development
subclass of: Restriction
  on property: part_of
  some values from: gamete generation

spermatogenesis
type: Class
subclass of: male gamete generation

spermatid development
type: Class
subclass of: germ cell development
subclass of: Restriction
  on property: part_of
  some values from: spermatid differentiation

female gamete generation
type: Class
subclass of: gamete generation

insemination
type: Class
subclass of: multi-organism reproductive process
subclass of: multi-multicellular organism process
subclass of: multicellular organismal reproductive process
subclass of: Restriction
  on property: part_of
  some values from: copulation

gastrulation
type: Class
subclass of: embryonic morphogenesis
subclass of: Restriction
  on property: has_part
  some values from: ectoderm formation
subclass of: Restriction
  on property: has_part
  some values from: endoderm formation
subclass of: Restriction
  on property: has_part
  some values from: mesoderm formation

ectoderm development
type: Class
subclass of: tissue development

nervous system development
type: Class
subclass of: system development

endoderm development
type: Class
subclass of: tissue development

mesoderm development
type: Class
subclass of: tissue development

female pregnancy
type: Class
subclass of: multi-organism reproductive process
subclass of: multi-multicellular organism process

respiratory gaseous exchange
type: Class
subclass of: multicellular organismal process

digestion
type: Class
subclass of: multicellular organismal process

excretion
type: Class
subclass of: system process

body fluid secretion
type: Class
subclass of: secretion
subclass of: GO_0050878

lactation
type: Class
subclass of: body fluid secretion
subclass of: Restriction
  on property: part_of
  some values from: mammary gland development
subclass of: Restriction
  on property: has_part
  some values from: GO_0060156

blood coagulation
type: Class
subclass of: hemostasis
subclass of: coagulation
subclass of: Restriction
  on property: part_of
  some values from: wound healing

hemostasis
type: Class
subclass of: GO_0050878

sensory perception
type: Class
subclass of: GO_0050877

visual perception
type: Class
subclass of: GO_0050953

sensory perception of sound
type: Class
subclass of: GO_0050954

sensory perception of chemical stimulus
type: Class
subclass of: sensory perception

sensory perception of smell
type: Class
subclass of: sensory perception of chemical stimulus

behavior
type: Class
subclass of: biological_process

learning or memory
type: Class
subclass of: behavior
subclass of: GO_0050890

memory
type: Class
subclass of: learning or memory

mating behavior
type: Class
equivalent class: Class
  intersection of: behavior
  intersection of: Restriction
    on property: part_of
    some values from: mating
subclass of: reproductive behavior
subclass of: Restriction
  on property: part_of
  some values from: mating

mating
type: Class
subclass of: multi-organism reproductive process
subclass of: Restriction
  on property: part_of
  some values from: sexual reproduction

copulation
type: Class
subclass of: mating

locomotory behavior
type: Class
subclass of: behavior

blood circulation
type: Class
subclass of: circulatory system process

regulation of heart contraction
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: regulates
    some values from: GO_0060047
subclass of: GO_1903522
subclass of: Restriction
  on property: regulates
  some values from: GO_0060047

protein localization
type: Class
subclass of: macromolecule localization

biological_process
type: Class
subclass of: BFO_0000015

metabolic process
type: Class
subclass of: biological_process

steroid metabolic process
type: Class
subclass of: lipid metabolic process
subclass of: GO_1901360

bile acid metabolic process
type: Class
subclass of: steroid metabolic process
subclass of: monocarboxylic acid metabolic process
subclass of: GO_1901615

glucocorticoid metabolic process
type: Class
subclass of: steroid metabolic process

mineralocorticoid metabolic process
type: Class
subclass of: steroid metabolic process
subclass of: cellular hormone metabolic process

regulation of blood pressure
type: Class
subclass of: GO_0065008
subclass of: Restriction
  on property: part_of
  some values from: blood circulation

cell proliferation
type: Class
subclass of: biological_process

positive regulation of cell proliferation
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: positively regulates
    some values from: cell proliferation
subclass of: regulation of cell proliferation
subclass of: positive regulation of cellular process
subclass of: Restriction
  on property: positively regulates
  some values from: cell proliferation

negative regulation of cell proliferation
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: negatively regulates
    some values from: cell proliferation
subclass of: regulation of cell proliferation
subclass of: negative regulation of cellular process
subclass of: Restriction
  on property: negatively regulates
  some values from: cell proliferation

taste receptor activity
type: Class
subclass of: transmembrane signaling receptor activity
subclass of: Restriction
  on property: part_of
  some values from: GO_0050912

lipid biosynthetic process
type: Class
subclass of: lipid metabolic process
subclass of: GO_1901576

catabolic process
type: Class
subclass of: metabolic process

macromolecule catabolic process
type: Class
subclass of: macromolecule metabolic process
subclass of: GO_1901575

biosynthetic process
type: Class
subclass of: metabolic process

macromolecule biosynthetic process
type: Class
subclass of: macromolecule metabolic process
subclass of: GO_1901576

glucan biosynthetic process
type: Class
subclass of: cellular glucan metabolic process
subclass of: cellular polysaccharide biosynthetic process

glucan catabolic process
type: Class
subclass of: polysaccharide catabolic process
subclass of: glucan metabolic process

protein secretion
type: Class
subclass of: peptide secretion
subclass of: protein transport
subclass of: secretion by cell

response to radiation
type: Class
subclass of: response to abiotic stimulus

response to light stimulus
type: Class
subclass of: response to radiation

detection of external stimulus
type: Class
subclass of: response to external stimulus
subclass of: GO_0051606

detection of abiotic stimulus
type: Class
subclass of: response to abiotic stimulus
subclass of: GO_0051606

detection of light stimulus
type: Class
subclass of: response to light stimulus
subclass of: detection of external stimulus
subclass of: detection of abiotic stimulus

detection of visible light
type: Class
subclass of: detection of light stimulus

detection of chemical stimulus
type: Class
subclass of: GO_0051606
subclass of: Restriction
  on property: part_of
  some values from: response to chemical

response to external stimulus
type: Class
subclass of: GO_0050896

response to wounding
type: Class
subclass of: response to stress

response to mechanical stimulus
type: Class
subclass of: response to external stimulus
subclass of: response to abiotic stimulus

response to abiotic stimulus
type: Class
subclass of: GO_0050896

anatomical structure morphogenesis
type: Class
subclass of: developmental process
subclass of: Restriction
  on property: part_of
  some values from: anatomical structure development

embryo development
type: Class
subclass of: multicellular organism development

post-embryonic development
type: Class
subclass of: multicellular organismal process
subclass of: Restriction
  on property: part_of
  some values from: multicellular organism development

embryo development ending in birth or egg hatching
type: Class
subclass of: embryo development

tissue development
type: Class
subclass of: anatomical structure development

regulation of biosynthetic process
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: regulates
    some values from: biosynthetic process
subclass of: regulation of metabolic process
subclass of: Restriction
  on property: regulates
  some values from: biosynthetic process

negative regulation of biosynthetic process
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: negatively regulates
    some values from: biosynthetic process
subclass of: regulation of biosynthetic process
subclass of: negative regulation of metabolic process
subclass of: Restriction
  on property: negatively regulates
  some values from: biosynthetic process

positive regulation of biosynthetic process
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: positively regulates
    some values from: biosynthetic process
subclass of: regulation of biosynthetic process
subclass of: positive regulation of metabolic process
subclass of: Restriction
  on property: positively regulates
  some values from: biosynthetic process

negative regulation of metabolic process
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: negatively regulates
    some values from: metabolic process
subclass of: regulation of metabolic process
subclass of: negative regulation of biological process
subclass of: Restriction
  on property: negatively regulates
  some values from: metabolic process

positive regulation of metabolic process
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: positively regulates
    some values from: metabolic process
subclass of: regulation of metabolic process
subclass of: positive regulation of biological process
subclass of: Restriction
  on property: positively regulates
  some values from: metabolic process

regulation of catabolic process
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: regulates
    some values from: catabolic process
subclass of: regulation of metabolic process
subclass of: Restriction
  on property: regulates
  some values from: catabolic process

negative regulation of catabolic process
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: negatively regulates
    some values from: catabolic process
subclass of: negative regulation of metabolic process
subclass of: regulation of catabolic process
subclass of: Restriction
  on property: negatively regulates
  some values from: catabolic process

positive regulation of catabolic process
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: positively regulates
    some values from: catabolic process
subclass of: positive regulation of metabolic process
subclass of: regulation of catabolic process
subclass of: Restriction
  on property: positively regulates
  some values from: catabolic process

hormone transport
type: Class
subclass of: transport
subclass of: regulation of hormone levels

regulation of signal transduction
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: regulates
    some values from: signal transduction
subclass of: regulation of cell communication
subclass of: regulation of signaling
subclass of: regulation of response to stimulus
subclass of: Restriction
  on property: regulates
  some values from: signal transduction

positive regulation of signal transduction
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: positively regulates
    some values from: signal transduction
subclass of: regulation of signal transduction
subclass of: positive regulation of cell communication
subclass of: positive regulation of signaling
subclass of: positive regulation of response to stimulus
subclass of: Restriction
  on property: positively regulates
  some values from: signal transduction

negative regulation of signal transduction
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: negatively regulates
    some values from: signal transduction
subclass of: regulation of signal transduction
subclass of: negative regulation of cell communication
subclass of: negative regulation of signaling
subclass of: negative regulation of response to stimulus
subclass of: Restriction
  on property: negatively regulates
  some values from: signal transduction

cellular process
type: Class
subclass of: biological_process

mesenchymal cell proliferation
type: Class
subclass of: cell proliferation

regulation of mesenchymal cell proliferation
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: regulates
    some values from: mesenchymal cell proliferation
subclass of: regulation of cell proliferation
subclass of: Restriction
  on property: regulates
  some values from: mesenchymal cell proliferation

regulation of receptor activity
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: regulates
    some values from: receptor activity
subclass of: regulation of signal transduction
subclass of: GO_0065009
subclass of: Restriction
  on property: regulates
  some values from: receptor activity

regulation of gastrulation
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: regulates
    some values from: gastrulation
subclass of: regulation of anatomical structure morphogenesis
subclass of: regulation of embryonic development
subclass of: Restriction
  on property: regulates
  some values from: gastrulation

regulation of macromolecule biosynthetic process
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: regulates
    some values from: macromolecule biosynthetic process
subclass of: regulation of biosynthetic process
subclass of: GO_0060255
subclass of: Restriction
  on property: regulates
  some values from: macromolecule biosynthetic process

positive regulation of macromolecule biosynthetic process
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: positively regulates
    some values from: macromolecule biosynthetic process
subclass of: positive regulation of biosynthetic process
subclass of: regulation of macromolecule biosynthetic process
subclass of: positive regulation of macromolecule metabolic process
subclass of: Restriction
  on property: positively regulates
  some values from: macromolecule biosynthetic process

negative regulation of macromolecule biosynthetic process
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: negatively regulates
    some values from: macromolecule biosynthetic process
subclass of: negative regulation of biosynthetic process
subclass of: regulation of macromolecule biosynthetic process
subclass of: negative regulation of macromolecule metabolic process
subclass of: Restriction
  on property: negatively regulates
  some values from: macromolecule biosynthetic process

regulation of cellular ketone metabolic process
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: regulates
    some values from: cellular ketone metabolic process
subclass of: regulation of cellular metabolic process
subclass of: Restriction
  on property: regulates
  some values from: cellular ketone metabolic process

positive regulation of macromolecule metabolic process
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: positively regulates
    some values from: macromolecule metabolic process
subclass of: positive regulation of metabolic process
subclass of: GO_0060255
subclass of: Restriction
  on property: positively regulates
  some values from: macromolecule metabolic process

negative regulation of macromolecule metabolic process
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: negatively regulates
    some values from: macromolecule metabolic process
subclass of: negative regulation of metabolic process
subclass of: GO_0060255
subclass of: Restriction
  on property: negatively regulates
  some values from: macromolecule metabolic process

positive regulation of organelle organization
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: positively regulates
    some values from: organelle organization
subclass of: regulation of organelle organization
subclass of: GO_0051130
subclass of: Restriction
  on property: positively regulates
  some values from: organelle organization

negative regulation of organelle organization
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: negatively regulates
    some values from: organelle organization
subclass of: regulation of organelle organization
subclass of: GO_0051129
subclass of: Restriction
  on property: negatively regulates
  some values from: organelle organization

regulation of cell communication
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: regulates
    some values from: cell communication
subclass of: regulation of cellular process
subclass of: Restriction
  on property: regulates
  some values from: cell communication

positive regulation of cell communication
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: positively regulates
    some values from: cell communication
subclass of: regulation of cell communication
subclass of: positive regulation of cellular process
subclass of: Restriction
  on property: positively regulates
  some values from: cell communication

negative regulation of cell communication
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: negatively regulates
    some values from: cell communication
subclass of: regulation of cell communication
subclass of: negative regulation of cellular process
subclass of: Restriction
  on property: negatively regulates
  some values from: cell communication

regulation of cellular carbohydrate metabolic process
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: regulates
    some values from: cellular carbohydrate metabolic process
subclass of: regulation of carbohydrate metabolic process
subclass of: regulation of cellular metabolic process
subclass of: Restriction
  on property: regulates
  some values from: cellular carbohydrate metabolic process

positive regulation of cellular carbohydrate metabolic process
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: positively regulates
    some values from: cellular carbohydrate metabolic process
subclass of: regulation of cellular carbohydrate metabolic process
subclass of: positive regulation of cellular metabolic process
subclass of: positive regulation of carbohydrate metabolic process
subclass of: Restriction
  on property: positively regulates
  some values from: cellular carbohydrate metabolic process

negative regulation of cellular carbohydrate metabolic process
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: negatively regulates
    some values from: cellular carbohydrate metabolic process
subclass of: regulation of cellular carbohydrate metabolic process
subclass of: negative regulation of cellular metabolic process
subclass of: negative regulation of carbohydrate metabolic process
subclass of: Restriction
  on property: negatively regulates
  some values from: cellular carbohydrate metabolic process

negative regulation of norepinephrine secretion
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: negatively regulates
    some values from: norepinephrine secretion
subclass of: regulation of norepinephrine secretion
subclass of: negative regulation of catecholamine secretion
subclass of: Restriction
  on property: negatively regulates
  some values from: norepinephrine secretion

positive regulation of norepinephrine secretion
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: positively regulates
    some values from: norepinephrine secretion
subclass of: regulation of norepinephrine secretion
subclass of: positive regulation of catecholamine secretion
subclass of: Restriction
  on property: positively regulates
  some values from: norepinephrine secretion

positive regulation of cell development
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: positively regulates
    some values from: cell development
subclass of: positive regulation of cell differentiation
subclass of: GO_0060284
subclass of: Restriction
  on property: positively regulates
  some values from: cell development

negative regulation of cell development
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: negatively regulates
    some values from: cell development
subclass of: negative regulation of cell differentiation
subclass of: GO_0060284
subclass of: Restriction
  on property: negatively regulates
  some values from: cell development

regulation of hormone levels
type: Class
subclass of: GO_0065008

lipid localization
type: Class
subclass of: macromolecule localization

positive regulation of steroid biosynthetic process
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: positively regulates
    some values from: steroid biosynthetic process
subclass of: positive regulation of steroid metabolic process
subclass of: positive regulation of lipid biosynthetic process
subclass of: regulation of steroid biosynthetic process
subclass of: Restriction
  on property: positively regulates
  some values from: steroid biosynthetic process

negative regulation of steroid biosynthetic process
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: negatively regulates
    some values from: steroid biosynthetic process
subclass of: negative regulation of steroid metabolic process
subclass of: regulation of steroid biosynthetic process
subclass of: GO_0051055
subclass of: Restriction
  on property: negatively regulates
  some values from: steroid biosynthetic process

regulation of glucose metabolic process
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: regulates
    some values from: glucose metabolic process
subclass of: regulation of cellular carbohydrate metabolic process
subclass of: Restriction
  on property: regulates
  some values from: glucose metabolic process

positive regulation of glucose metabolic process
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: positively regulates
    some values from: glucose metabolic process
subclass of: positive regulation of cellular carbohydrate metabolic process
subclass of: regulation of glucose metabolic process
subclass of: Restriction
  on property: positively regulates
  some values from: glucose metabolic process

regulation of glucan biosynthetic process
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: regulates
    some values from: glucan biosynthetic process
subclass of: regulation of cellular carbohydrate metabolic process
subclass of: regulation of polysaccharide biosynthetic process
subclass of: GO_2000112
subclass of: Restriction
  on property: regulates
  some values from: glucan biosynthetic process

regulation of norepinephrine secretion
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: regulates
    some values from: norepinephrine secretion
subclass of: regulation of catecholamine secretion
subclass of: Restriction
  on property: regulates
  some values from: norepinephrine secretion

regulation of serotonin secretion
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: regulates
    some values from: serotonin secretion
subclass of: regulation of ion transport
subclass of: GO_1903530
subclass of: Restriction
  on property: regulates
  some values from: serotonin secretion

negative regulation of serotonin secretion
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: negatively regulates
    some values from: serotonin secretion
subclass of: regulation of serotonin secretion
subclass of: negative regulation of ion transport
subclass of: GO_1903531
subclass of: Restriction
  on property: negatively regulates
  some values from: serotonin secretion

positive regulation of serotonin secretion
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: positively regulates
    some values from: serotonin secretion
subclass of: regulation of serotonin secretion
subclass of: positive regulation of ion transport
subclass of: GO_1903532
subclass of: Restriction
  on property: positively regulates
  some values from: serotonin secretion

phasic smooth muscle contraction
type: Class
subclass of: smooth muscle contraction

urinary bladder smooth muscle contraction
type: Class
subclass of: urinary tract smooth muscle contraction

urinary tract smooth muscle contraction
type: Class
subclass of: smooth muscle contraction

protein transport
type: Class
subclass of: peptide transport
subclass of: establishment of protein localization

actin cytoskeleton
type: Class
subclass of: cytoskeleton

ammonium transport
type: Class
subclass of: cation transport
subclass of: GO_0071705

organic anion transport
type: Class
subclass of: anion transport
subclass of: GO_0071702

monocarboxylic acid transport
type: Class
subclass of: carboxylic acid transport

bile acid and bile salt transport
type: Class
subclass of: lipid transport
subclass of: monocarboxylic acid transport
subclass of: organic hydroxy compound transport

peptide transport
type: Class
subclass of: amide transport
subclass of: GO_0071702

amine transport
type: Class
subclass of: GO_0071702
subclass of: GO_0071705

monoamine transport
type: Class
subclass of: GO_0071702
subclass of: GO_0071705

organic acid transport
type: Class
subclass of: GO_0071702

organic hydroxy compound transport
type: Class
subclass of: GO_0071702

norepinephrine transport
type: Class
subclass of: GO_0051937

energy derivation by oxidation of organic compounds
type: Class
subclass of: generation of precursor metabolites and energy
subclass of: GO_0055114

membrane
type: Class
subclass of: cellular_component

cellular component organization
type: Class
subclass of: cellular process
subclass of: GO_0071840

vesicle organization
type: Class
subclass of: organelle organization

carbohydrate biosynthetic process
type: Class
subclass of: carbohydrate metabolic process
subclass of: GO_1901576

carbohydrate catabolic process
type: Class
subclass of: carbohydrate metabolic process
subclass of: GO_1901575

organic acid biosynthetic process
type: Class
subclass of: organic acid metabolic process
subclass of: cellular biosynthetic process
subclass of: small molecule biosynthetic process
subclass of: GO_1901576

vesicle-mediated transport
type: Class
subclass of: transport

obsolete death
type: Class

morphogenesis of embryonic epithelium
type: Class
subclass of: morphogenesis of an epithelium
subclass of: embryonic morphogenesis

cell migration
type: Class
subclass of: cell motility

negative regulation of angiogenesis
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: negatively regulates
    some values from: angiogenesis
subclass of: regulation of angiogenesis
subclass of: GO_2000181
subclass of: Restriction
  on property: negatively regulates
  some values from: angiogenesis

stem cell division
type: Class
subclass of: GO_0051301

regulation of exocytosis
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: regulates
    some values from: exocytosis
subclass of: GO_0060627
subclass of: GO_1903530
subclass of: Restriction
  on property: regulates
  some values from: exocytosis

heterocycle biosynthetic process
type: Class
subclass of: cellular biosynthetic process
subclass of: heterocycle metabolic process

phenol-containing compound metabolic process
type: Class
subclass of: cellular aromatic compound metabolic process
subclass of: GO_1901360
subclass of: GO_1901615

reproductive behavior
type: Class
equivalent class: Class
  intersection of: behavior
  intersection of: Restriction
    on property: part_of
    some values from: reproduction
subclass of: behavior
subclass of: multicellular organismal reproductive process

regulation of lipid metabolic process
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: regulates
    some values from: lipid metabolic process
subclass of: GO_0080090
subclass of: Restriction
  on property: regulates
  some values from: lipid metabolic process

regulation of steroid metabolic process
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: regulates
    some values from: steroid metabolic process
subclass of: regulation of lipid metabolic process
subclass of: Restriction
  on property: regulates
  some values from: steroid metabolic process

regulation of metabolic process
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: regulates
    some values from: metabolic process
subclass of: regulation of biological process
subclass of: Restriction
  on property: regulates
  some values from: metabolic process

hexose metabolic process
type: Class
subclass of: monosaccharide metabolic process

aromatic compound biosynthetic process
type: Class
subclass of: cellular aromatic compound metabolic process
subclass of: cellular biosynthetic process

carboxylic acid metabolic process
type: Class
subclass of: oxoacid metabolic process

sexual reproduction
type: Class
subclass of: reproduction
subclass of: multi-organism reproductive process

developmental maturation
type: Class
subclass of: developmental process

neural tube development
type: Class
subclass of: tube development
subclass of: GO_0060429
subclass of: Restriction
  on property: part_of
  some values from: nervous system development
subclass of: Restriction
  on property: part_of
  some values from: chordate embryonic development

neurogenesis
type: Class
subclass of: cell differentiation
subclass of: Restriction
  on property: part_of
  some values from: nervous system development

regulation of cell-cell adhesion
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: regulates
    some values from: GO_0098609
subclass of: regulation of cell adhesion
subclass of: Restriction
  on property: regulates
  some values from: GO_0098609

negative regulation of cell-cell adhesion
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: negatively regulates
    some values from: GO_0098609
subclass of: negative regulation of cell adhesion
subclass of: regulation of cell-cell adhesion
subclass of: Restriction
  on property: negatively regulates
  some values from: GO_0098609

positive regulation of cell-cell adhesion
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: positively regulates
    some values from: GO_0098609
subclass of: regulation of cell-cell adhesion
subclass of: positive regulation of cell adhesion
subclass of: Restriction
  on property: positively regulates
  some values from: GO_0098609

cellular process involved in reproduction in multicellular organism
type: Class
equivalent class: Class
  intersection of: cellular process
  intersection of: Restriction
    on property: part_of
    some values from: multicellular organism reproduction
subclass of: cellular process
subclass of: reproductive process
subclass of: Restriction
  on property: part_of
  some values from: multicellular organism reproduction

reproductive process
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: part_of
    some values from: reproduction
subclass of: biological_process
subclass of: Restriction
  on property: part_of
  some values from: reproduction

digestive system process
type: Class
equivalent class: Class
  intersection of: system process
  intersection of: Restriction
    on property: part_of
    some values from: digestion
subclass of: system process
subclass of: Restriction
  on property: part_of
  some values from: digestion

regulation of anatomical structure morphogenesis
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: regulates
    some values from: anatomical structure morphogenesis
subclass of: regulation of developmental process
subclass of: Restriction
  on property: regulates
  some values from: anatomical structure morphogenesis

biological adhesion
type: Class
subclass of: biological_process

regulation of signaling
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: regulates
    some values from: signaling
subclass of: regulation of biological process
subclass of: Restriction
  on property: regulates
  some values from: signaling

signaling
type: Class
subclass of: biological_process

positive regulation of signaling
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: positively regulates
    some values from: signaling
subclass of: regulation of signaling
subclass of: positive regulation of biological process
subclass of: Restriction
  on property: positively regulates
  some values from: signaling

negative regulation of signaling
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: negatively regulates
    some values from: signaling
subclass of: regulation of signaling
subclass of: negative regulation of biological process
subclass of: Restriction
  on property: negatively regulates
  some values from: signaling

signal release
type: Class
equivalent class: Class
  intersection of: secretion by cell
  intersection of: Restriction
    on property: part_of
    some values from: cell-cell signaling
subclass of: secretion by cell
subclass of: Restriction
  on property: part_of
  some values from: cell-cell signaling

myofibril
type: Class
subclass of: contractile fiber

cell junction
type: Class
subclass of: cellular_component

peptide hormone secretion
type: Class
subclass of: peptide secretion
subclass of: hormone secretion

insulin secretion
type: Class
subclass of: protein secretion
subclass of: peptide hormone secretion

hemopoiesis
type: Class
subclass of: hematopoietic or lymphoid organ development

lymphocyte differentiation
type: Class
subclass of: leukocyte differentiation
subclass of: lymphocyte activation

vasopressin secretion
type: Class
subclass of: peptide hormone secretion

water homeostasis
type: Class
subclass of: chemical homeostasis

cell differentiation
type: Class
subclass of: cellular developmental process

regulation of cell adhesion
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: regulates
    some values from: cell adhesion
subclass of: regulation of biological process
subclass of: Restriction
  on property: regulates
  some values from: cell adhesion

B cell differentiation
type: Class
subclass of: lymphocyte differentiation
subclass of: B cell activation

melatonin metabolic process
type: Class
subclass of: cellular hormone metabolic process
subclass of: indole-containing compound metabolic process
subclass of: cellular amide metabolic process

melatonin biosynthetic process
type: Class
subclass of: melatonin metabolic process
subclass of: indole-containing compound biosynthetic process
subclass of: hormone biosynthetic process
subclass of: amide biosynthetic process

regulation of blood coagulation
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: regulates
    some values from: blood coagulation
subclass of: regulation of response to external stimulus
subclass of: regulation of coagulation
subclass of: GO_0061041
subclass of: GO_1900046
subclass of: Restriction
  on property: regulates
  some values from: blood coagulation

positive regulation of blood coagulation
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: positively regulates
    some values from: blood coagulation
subclass of: regulation of blood coagulation
subclass of: GO_0050820
subclass of: GO_0090303
subclass of: GO_1900048
subclass of: Restriction
  on property: positively regulates
  some values from: blood coagulation

negative regulation of blood coagulation
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: negatively regulates
    some values from: blood coagulation
subclass of: regulation of blood coagulation
subclass of: GO_0050819
subclass of: GO_0061045
subclass of: GO_1900047
subclass of: Restriction
  on property: negatively regulates
  some values from: blood coagulation

extracellular matrix organization
type: Class
subclass of: extracellular structure organization

T cell differentiation
type: Class
subclass of: lymphocyte differentiation
subclass of: T cell activation

regulation of ossification
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: regulates
    some values from: ossification
subclass of: GO_0051239
subclass of: Restriction
  on property: regulates
  some values from: ossification

negative regulation of ossification
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: negatively regulates
    some values from: ossification
subclass of: regulation of ossification
subclass of: GO_0051241
subclass of: Restriction
  on property: negatively regulates
  some values from: ossification

flagellated sperm motility
type: Class
subclass of: GO_0097722

regulation of cell migration
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: regulates
    some values from: cell migration
subclass of: GO_2000145
subclass of: Restriction
  on property: regulates
  some values from: cell migration

positive regulation of cell migration
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: positively regulates
    some values from: cell migration
subclass of: regulation of cell migration
subclass of: GO_2000147
subclass of: Restriction
  on property: positively regulates
  some values from: cell migration

negative regulation of cell migration
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: negatively regulates
    some values from: cell migration
subclass of: regulation of cell migration
subclass of: GO_2000146
subclass of: Restriction
  on property: negatively regulates
  some values from: cell migration

defecation
type: Class
subclass of: excretion

axon
type: Class
subclass of: neuron projection

peristalsis
type: Class
subclass of: phasic smooth muscle contraction

epithelial cell differentiation
type: Class
subclass of: cell differentiation
subclass of: Restriction
  on property: part_of
  some values from: GO_0060429

regulation of epithelial cell differentiation
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: regulates
    some values from: epithelial cell differentiation
subclass of: regulation of cell differentiation
subclass of: GO_2000026
subclass of: Restriction
  on property: regulates
  some values from: epithelial cell differentiation

negative regulation of epithelial cell differentiation
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: negatively regulates
    some values from: epithelial cell differentiation
subclass of: regulation of epithelial cell differentiation
subclass of: negative regulation of cell differentiation
subclass of: Restriction
  on property: negatively regulates
  some values from: epithelial cell differentiation

positive regulation of epithelial cell differentiation
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: positively regulates
    some values from: epithelial cell differentiation
subclass of: regulation of epithelial cell differentiation
subclass of: positive regulation of cell differentiation
subclass of: Restriction
  on property: positively regulates
  some values from: epithelial cell differentiation

mammary gland development
type: Class
subclass of: gland development

regulation of B cell proliferation
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: regulates
    some values from: B cell proliferation
subclass of: regulation of lymphocyte proliferation
subclass of: GO_0050864
subclass of: Restriction
  on property: regulates
  some values from: B cell proliferation

negative regulation of B cell proliferation
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: negatively regulates
    some values from: B cell proliferation
subclass of: regulation of B cell proliferation
subclass of: negative regulation of lymphocyte proliferation
subclass of: GO_0050869
subclass of: Restriction
  on property: negatively regulates
  some values from: B cell proliferation

positive regulation of B cell proliferation
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: positively regulates
    some values from: B cell proliferation
subclass of: regulation of B cell proliferation
subclass of: positive regulation of lymphocyte proliferation
subclass of: GO_0050871
subclass of: Restriction
  on property: positively regulates
  some values from: B cell proliferation

extracellular matrix
type: Class
subclass of: extracellular region part

regulation of cellular metabolic process
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: regulates
    some values from: cellular metabolic process
subclass of: regulation of metabolic process
subclass of: regulation of cellular process
subclass of: Restriction
  on property: regulates
  some values from: cellular metabolic process

negative regulation of cellular metabolic process
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: negatively regulates
    some values from: cellular metabolic process
subclass of: negative regulation of metabolic process
subclass of: regulation of cellular metabolic process
subclass of: negative regulation of cellular process
subclass of: Restriction
  on property: negatively regulates
  some values from: cellular metabolic process

positive regulation of cellular metabolic process
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: positively regulates
    some values from: cellular metabolic process
subclass of: positive regulation of metabolic process
subclass of: regulation of cellular metabolic process
subclass of: positive regulation of cellular process
subclass of: Restriction
  on property: positively regulates
  some values from: cellular metabolic process

regulation of cellular biosynthetic process
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: regulates
    some values from: cellular biosynthetic process
subclass of: regulation of biosynthetic process
subclass of: regulation of cellular metabolic process
subclass of: Restriction
  on property: regulates
  some values from: cellular biosynthetic process

negative regulation of cellular biosynthetic process
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: negatively regulates
    some values from: cellular biosynthetic process
subclass of: negative regulation of biosynthetic process
subclass of: negative regulation of cellular metabolic process
subclass of: regulation of cellular biosynthetic process
subclass of: Restriction
  on property: negatively regulates
  some values from: cellular biosynthetic process

positive regulation of cellular biosynthetic process
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: positively regulates
    some values from: cellular biosynthetic process
subclass of: positive regulation of biosynthetic process
subclass of: positive regulation of cellular metabolic process
subclass of: regulation of cellular biosynthetic process
subclass of: Restriction
  on property: positively regulates
  some values from: cellular biosynthetic process

regulation of cellular catabolic process
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: regulates
    some values from: cellular catabolic process
subclass of: regulation of catabolic process
subclass of: regulation of cellular metabolic process
subclass of: Restriction
  on property: regulates
  some values from: cellular catabolic process

negative regulation of cellular catabolic process
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: negatively regulates
    some values from: cellular catabolic process
subclass of: negative regulation of catabolic process
subclass of: negative regulation of cellular metabolic process
subclass of: regulation of cellular catabolic process
subclass of: Restriction
  on property: negatively regulates
  some values from: cellular catabolic process

positive regulation of cellular catabolic process
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: positively regulates
    some values from: cellular catabolic process
subclass of: positive regulation of catabolic process
subclass of: positive regulation of cellular metabolic process
subclass of: regulation of cellular catabolic process
subclass of: Restriction
  on property: positively regulates
  some values from: cellular catabolic process

regulation of vesicle fusion
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: regulates
    some values from: vesicle fusion
subclass of: regulation of organelle organization
subclass of: GO_0060627
subclass of: Restriction
  on property: regulates
  some values from: vesicle fusion

negative regulation of vesicle fusion
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: negatively regulates
    some values from: vesicle fusion
subclass of: negative regulation of organelle organization
subclass of: regulation of vesicle fusion
subclass of: GO_0051051
subclass of: Restriction
  on property: negatively regulates
  some values from: vesicle fusion

positive regulation of vesicle fusion
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: positively regulates
    some values from: vesicle fusion
subclass of: positive regulation of organelle organization
subclass of: regulation of vesicle fusion
subclass of: GO_0051050
subclass of: Restriction
  on property: positively regulates
  some values from: vesicle fusion

cytoplasmic vesicle
type: Class
equivalent class: Class
  intersection of: vesicle
  intersection of: Restriction
    on property: part_of
    some values from: cytoplasm
subclass of: cytoplasmic part
subclass of: GO_0097708

regulation of neurological system process
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: regulates
    some values from: GO_0050877
subclass of: regulation of system process
subclass of: Restriction
  on property: regulates
  some values from: GO_0050877

negative regulation of neurological system process
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: negatively regulates
    some values from: GO_0050877
subclass of: regulation of neurological system process
subclass of: GO_0051241
subclass of: Restriction
  on property: negatively regulates
  some values from: GO_0050877

positive regulation of neurological system process
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: positively regulates
    some values from: GO_0050877
subclass of: regulation of neurological system process
subclass of: GO_0051240
subclass of: Restriction
  on property: positively regulates
  some values from: GO_0050877

regulation of glucocorticoid metabolic process
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: regulates
    some values from: glucocorticoid metabolic process
subclass of: regulation of steroid metabolic process
subclass of: regulation of cellular metabolic process
subclass of: regulation of hormone metabolic process
subclass of: Restriction
  on property: regulates
  some values from: glucocorticoid metabolic process

negative regulation of glucocorticoid metabolic process
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: negatively regulates
    some values from: glucocorticoid metabolic process
subclass of: negative regulation of cellular metabolic process
subclass of: regulation of glucocorticoid metabolic process
subclass of: negative regulation of hormone metabolic process
subclass of: negative regulation of steroid metabolic process
subclass of: Restriction
  on property: negatively regulates
  some values from: glucocorticoid metabolic process

positive regulation of glucocorticoid metabolic process
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: positively regulates
    some values from: glucocorticoid metabolic process
subclass of: positive regulation of cellular metabolic process
subclass of: regulation of glucocorticoid metabolic process
subclass of: positive regulation of hormone metabolic process
subclass of: positive regulation of steroid metabolic process
subclass of: Restriction
  on property: positively regulates
  some values from: glucocorticoid metabolic process

regulation of glucocorticoid biosynthetic process
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: regulates
    some values from: glucocorticoid biosynthetic process
subclass of: regulation of glucocorticoid metabolic process
subclass of: GO_0090030
subclass of: Restriction
  on property: regulates
  some values from: glucocorticoid biosynthetic process

negative regulation of glucocorticoid biosynthetic process
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: negatively regulates
    some values from: glucocorticoid biosynthetic process
subclass of: negative regulation of glucocorticoid metabolic process
subclass of: regulation of glucocorticoid biosynthetic process
subclass of: GO_0090032
subclass of: Restriction
  on property: negatively regulates
  some values from: glucocorticoid biosynthetic process

positive regulation of glucocorticoid biosynthetic process
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: positively regulates
    some values from: glucocorticoid biosynthetic process
subclass of: positive regulation of glucocorticoid metabolic process
subclass of: regulation of glucocorticoid biosynthetic process
subclass of: GO_0090031
subclass of: Restriction
  on property: positively regulates
  some values from: glucocorticoid biosynthetic process

vesicle
type: Class
subclass of: membrane-bounded organelle

locomotion involved in locomotory behavior
type: Class
equivalent class: Class
  intersection of: locomotion
  intersection of: Restriction
    on property: part_of
    some values from: locomotory behavior
subclass of: locomotion
subclass of: Restriction
  on property: part_of
  some values from: locomotory behavior

positive regulation of insulin secretion
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: positively regulates
    some values from: insulin secretion
subclass of: positive regulation of protein secretion
subclass of: regulation of insulin secretion
subclass of: GO_0090277
subclass of: Restriction
  on property: positively regulates
  some values from: insulin secretion

regulation of response to external stimulus
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: regulates
    some values from: response to external stimulus
subclass of: regulation of response to stimulus
subclass of: Restriction
  on property: regulates
  some values from: response to external stimulus

negative regulation of response to external stimulus
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: negatively regulates
    some values from: response to external stimulus
subclass of: regulation of response to external stimulus
subclass of: negative regulation of response to stimulus
subclass of: Restriction
  on property: negatively regulates
  some values from: response to external stimulus

positive regulation of response to external stimulus
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: positively regulates
    some values from: response to external stimulus
subclass of: regulation of response to external stimulus
subclass of: positive regulation of response to stimulus
subclass of: Restriction
  on property: positively regulates
  some values from: response to external stimulus

regulation of hormone metabolic process
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: regulates
    some values from: hormone metabolic process
subclass of: regulation of hormone levels
subclass of: regulation of metabolic process
subclass of: Restriction
  on property: regulates
  some values from: hormone metabolic process

negative regulation of hormone metabolic process
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: negatively regulates
    some values from: hormone metabolic process
subclass of: negative regulation of metabolic process
subclass of: regulation of hormone metabolic process
subclass of: Restriction
  on property: negatively regulates
  some values from: hormone metabolic process

positive regulation of hormone metabolic process
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: positively regulates
    some values from: hormone metabolic process
subclass of: positive regulation of metabolic process
subclass of: regulation of hormone metabolic process
subclass of: Restriction
  on property: positively regulates
  some values from: hormone metabolic process

negative regulation of hormone biosynthetic process
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: negatively regulates
    some values from: hormone biosynthetic process
subclass of: negative regulation of cellular biosynthetic process
subclass of: negative regulation of hormone metabolic process
subclass of: regulation of hormone biosynthetic process
subclass of: Restriction
  on property: negatively regulates
  some values from: hormone biosynthetic process

regulation of lipid transport
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: regulates
    some values from: lipid transport
subclass of: GO_0051049
subclass of: GO_1905952
subclass of: Restriction
  on property: regulates
  some values from: lipid transport

negative regulation of lipid transport
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: negatively regulates
    some values from: lipid transport
subclass of: regulation of lipid transport
subclass of: GO_0051051
subclass of: GO_1905953
subclass of: Restriction
  on property: negatively regulates
  some values from: lipid transport

positive regulation of lipid transport
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: positively regulates
    some values from: lipid transport
subclass of: regulation of lipid transport
subclass of: GO_0051050
subclass of: GO_1905954
subclass of: Restriction
  on property: positively regulates
  some values from: lipid transport

actin filament bundle
type: Class
subclass of: cytoskeletal part
subclass of: Restriction
  on property: part_of
  some values from: actin cytoskeleton
subclass of: Restriction
  on property: has_part
  some values from: actin filament

multicellular organismal process
type: Class
subclass of: biological_process

developmental process
type: Class
subclass of: biological_process

multicellular organism reproduction
type: Class
subclass of: reproduction
subclass of: multicellular organismal process

monocarboxylic acid metabolic process
type: Class
subclass of: carboxylic acid metabolic process

cell projection cytoplasm
type: Class
equivalent class: Class
  intersection of: cytoplasm
  intersection of: Restriction
    on property: part_of
    some values from: GO_0120025
subclass of: GO_0099568
subclass of: GO_0120038

regulation of homeostatic process
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: regulates
    some values from: homeostatic process
subclass of: regulation of biological process
subclass of: GO_0065008
subclass of: Restriction
  on property: regulates
  some values from: homeostatic process

negative regulation of homeostatic process
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: negatively regulates
    some values from: homeostatic process
subclass of: regulation of homeostatic process
subclass of: negative regulation of biological process
subclass of: Restriction
  on property: negatively regulates
  some values from: homeostatic process

positive regulation of homeostatic process
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: positively regulates
    some values from: homeostatic process
subclass of: regulation of homeostatic process
subclass of: positive regulation of biological process
subclass of: Restriction
  on property: positively regulates
  some values from: homeostatic process

regulation of localization
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: regulates
    some values from: GO_0051179
subclass of: regulation of biological process
subclass of: Restriction
  on property: regulates
  some values from: GO_0051179

regulation of protein localization
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: regulates
    some values from: protein localization
subclass of: regulation of localization
subclass of: Restriction
  on property: regulates
  some values from: protein localization

regulation of polysaccharide metabolic process
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: regulates
    some values from: polysaccharide metabolic process
subclass of: regulation of carbohydrate metabolic process
subclass of: GO_0060255
subclass of: Restriction
  on property: regulates
  some values from: polysaccharide metabolic process

regulation of polysaccharide biosynthetic process
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: regulates
    some values from: polysaccharide biosynthetic process
subclass of: regulation of macromolecule biosynthetic process
subclass of: regulation of polysaccharide metabolic process
subclass of: regulation of carbohydrate biosynthetic process
subclass of: Restriction
  on property: regulates
  some values from: polysaccharide biosynthetic process

regulation of organic acid transport
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: regulates
    some values from: organic acid transport
subclass of: GO_0051049
subclass of: Restriction
  on property: regulates
  some values from: organic acid transport

negative regulation of organic acid transport
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: negatively regulates
    some values from: organic acid transport
subclass of: regulation of organic acid transport
subclass of: GO_0051051
subclass of: Restriction
  on property: negatively regulates
  some values from: organic acid transport

positive regulation of organic acid transport
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: positively regulates
    some values from: organic acid transport
subclass of: regulation of organic acid transport
subclass of: GO_0051050
subclass of: Restriction
  on property: positively regulates
  some values from: organic acid transport

secretion by cell
type: Class
subclass of: cellular process
subclass of: secretion

secretion by tissue
type: Class
subclass of: multicellular organismal process
subclass of: secretion

mononuclear cell proliferation
type: Class
subclass of: GO_0070661

regulation of mononuclear cell proliferation
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: regulates
    some values from: mononuclear cell proliferation
subclass of: GO_0070663
subclass of: Restriction
  on property: regulates
  some values from: mononuclear cell proliferation

negative regulation of mononuclear cell proliferation
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: negatively regulates
    some values from: mononuclear cell proliferation
subclass of: regulation of mononuclear cell proliferation
subclass of: GO_0070664
subclass of: Restriction
  on property: negatively regulates
  some values from: mononuclear cell proliferation

positive regulation of mononuclear cell proliferation
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: positively regulates
    some values from: mononuclear cell proliferation
subclass of: regulation of mononuclear cell proliferation
subclass of: GO_0070665
subclass of: Restriction
  on property: positively regulates
  some values from: mononuclear cell proliferation

macromolecular complex
type: Class
subclass of: cellular_component

macromolecule localization
type: Class
subclass of: GO_0051179

regulation of organelle organization
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: regulates
    some values from: organelle organization
subclass of: GO_0051128
subclass of: Restriction
  on property: regulates
  some values from: organelle organization

axon part
type: Class
equivalent class: Class
  intersection of: cellular_component
  intersection of: Restriction
    on property: part_of
    some values from: axon
subclass of: GO_0097458
subclass of: GO_0120038
subclass of: Restriction
  on property: part_of
  some values from: axon

negative regulation of catecholamine secretion
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: negatively regulates
    some values from: catecholamine secretion
subclass of: regulation of catecholamine secretion
subclass of: GO_0051953
subclass of: GO_1903531
subclass of: Restriction
  on property: negatively regulates
  some values from: catecholamine secretion

positive regulation of catecholamine secretion
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: positively regulates
    some values from: catecholamine secretion
subclass of: regulation of catecholamine secretion
subclass of: GO_0051954
subclass of: GO_1903532
subclass of: Restriction
  on property: positively regulates
  some values from: catecholamine secretion

cellular polysaccharide biosynthetic process
type: Class
subclass of: polysaccharide biosynthetic process
subclass of: cellular carbohydrate biosynthetic process
subclass of: cellular macromolecule biosynthetic process
subclass of: cellular polysaccharide metabolic process

regulation of cellular amide metabolic process
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: regulates
    some values from: cellular amide metabolic process
subclass of: regulation of cellular metabolic process
subclass of: GO_0051171
subclass of: Restriction
  on property: regulates
  some values from: cellular amide metabolic process

negative regulation of cellular amide metabolic process
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: negatively regulates
    some values from: cellular amide metabolic process
subclass of: negative regulation of cellular metabolic process
subclass of: regulation of cellular amide metabolic process
subclass of: GO_0051172
subclass of: Restriction
  on property: negatively regulates
  some values from: cellular amide metabolic process

positive regulation of cellular amide metabolic process
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: positively regulates
    some values from: cellular amide metabolic process
subclass of: positive regulation of cellular metabolic process
subclass of: regulation of cellular amide metabolic process
subclass of: GO_0051173
subclass of: Restriction
  on property: positively regulates
  some values from: cellular amide metabolic process

cellular carbohydrate biosynthetic process
type: Class
subclass of: carbohydrate biosynthetic process
subclass of: cellular biosynthetic process
subclass of: cellular carbohydrate metabolic process

cellular nitrogen compound metabolic process
type: Class
subclass of: nitrogen compound metabolic process
subclass of: cellular metabolic process

cellular macromolecule biosynthetic process
type: Class
subclass of: macromolecule biosynthetic process
subclass of: cellular biosynthetic process
subclass of: cellular macromolecule metabolic process

cellular hormone metabolic process
type: Class
subclass of: hormone metabolic process
subclass of: cellular metabolic process

tube formation
type: Class
subclass of: anatomical structure formation involved in morphogenesis
subclass of: Restriction
  on property: part_of
  some values from: tube morphogenesis

tube morphogenesis
type: Class
subclass of: anatomical structure morphogenesis
subclass of: Restriction
  on property: part_of
  some values from: tube development

tube development
type: Class
subclass of: anatomical structure development
subclass of: Restriction
  on property: part_of
  some values from: multicellular organism development

regulation of urine volume
type: Class
subclass of: renal system process
subclass of: GO_0050878

parathyroid hormone secretion
type: Class
subclass of: GO_0060986

steroid hormone secretion
type: Class
subclass of: lipid transport
subclass of: GO_0060986

corticosteroid hormone secretion
type: Class
subclass of: steroid hormone secretion

mineralocorticoid secretion
type: Class
subclass of: corticosteroid hormone secretion

aldosterone secretion
type: Class
subclass of: organic hydroxy compound transport
subclass of: mineralocorticoid secretion

direct ossification
type: Class
subclass of: ossification

calcitonin secretion
type: Class
subclass of: peptide hormone secretion

myofilament
type: Class
subclass of: contractile fiber part
subclass of: Restriction
  on property: part_of
  some values from: myofibril

somatodendritic compartment
type: Class
subclass of: GO_0097458

signaling receptor activity
type: Class
equivalent class: Class
  intersection of: receptor activity
  intersection of: Restriction
    on property: part_of
    some values from: signal transduction
subclass of: signal transducer activity
subclass of: receptor activity

locomotion
type: Class
subclass of: biological_process

regulation of locomotion
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: regulates
    some values from: locomotion
subclass of: regulation of biological process
subclass of: Restriction
  on property: regulates
  some values from: locomotion

negative regulation of locomotion
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: negatively regulates
    some values from: locomotion
subclass of: regulation of locomotion
subclass of: negative regulation of biological process
subclass of: Restriction
  on property: negatively regulates
  some values from: locomotion

embryonic cleavage
type: Class
subclass of: GO_0051301
subclass of: Restriction
  on property: part_of
  some values from: embryo development

positive regulation of locomotion
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: positively regulates
    some values from: locomotion
subclass of: regulation of locomotion
subclass of: positive regulation of biological process
subclass of: Restriction
  on property: positively regulates
  some values from: locomotion

positive regulation of embryonic development
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: positively regulates
    some values from: embryo development
subclass of: regulation of embryonic development
subclass of: GO_0051094
subclass of: GO_0051240
subclass of: Restriction
  on property: positively regulates
  some values from: embryo development

fluid transport
type: Class
subclass of: transport

wound healing
type: Class
subclass of: response to wounding

cell migration involved in gastrulation
type: Class
equivalent class: Class
  intersection of: cell migration
  intersection of: Restriction
    on property: part_of
    some values from: gastrulation
subclass of: ameboidal-type cell migration
subclass of: Restriction
  on property: part_of
  some values from: gastrulation

B cell proliferation
type: Class
subclass of: B cell activation
subclass of: lymphocyte proliferation

T cell activation
type: Class
subclass of: lymphocyte activation

B cell activation
type: Class
subclass of: lymphocyte activation

regulation of cell proliferation
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: regulates
    some values from: cell proliferation
subclass of: regulation of cellular process
subclass of: Restriction
  on property: regulates
  some values from: cell proliferation

cellular ketone metabolic process
type: Class
subclass of: cellular metabolic process
subclass of: small molecule metabolic process
subclass of: GO_0071704

response to chemical
type: Class
subclass of: GO_0050896

thyroid hormone metabolic process
type: Class
subclass of: cellular modified amino acid metabolic process
subclass of: phenol-containing compound metabolic process
subclass of: hormone metabolic process

indole-containing compound metabolic process
type: Class
subclass of: cellular aromatic compound metabolic process
subclass of: cellular nitrogen compound metabolic process
subclass of: heterocycle metabolic process
subclass of: GO_1901360
subclass of: GO_1901564

indole-containing compound biosynthetic process
type: Class
subclass of: heterocycle biosynthetic process
subclass of: aromatic compound biosynthetic process
subclass of: indole-containing compound metabolic process
subclass of: cellular nitrogen compound biosynthetic process
subclass of: GO_1901362
subclass of: GO_1901566

hormone metabolic process
type: Class
subclass of: metabolic process
subclass of: regulation of hormone levels

hormone biosynthetic process
type: Class
subclass of: biosynthetic process
subclass of: hormone metabolic process

homeostatic process
type: Class
subclass of: GO_0065008

sperm ejaculation
type: Class
subclass of: multicellular organismal reproductive process
subclass of: Restriction
  on property: part_of
  some values from: insemination

amide transport
type: Class
subclass of: GO_0071705

cell projection
type: Class
subclass of: cell part

neuron projection
type: Class
subclass of: GO_0097458
subclass of: GO_0120025

chordate embryonic development
type: Class
subclass of: embryo development ending in birth or egg hatching

neuronal cell body
type: Class
subclass of: cell body
subclass of: GO_0097458
subclass of: Restriction
  on property: part_of
  some values from: somatodendritic compartment

extracellular structure organization
type: Class
subclass of: cellular component organization

macromolecule metabolic process
type: Class
subclass of: GO_0071704

myelin sheath
type: Class
subclass of: cell part

organelle
type: Class
subclass of: cellular_component

membrane-bounded organelle
type: Class
subclass of: organelle

non-membrane-bounded organelle
type: Class
subclass of: organelle

intracellular organelle
type: Class
equivalent class: Class
  intersection of: organelle
  intersection of: Restriction
    on property: part_of
    some values from: intracellular
subclass of: organelle
subclass of: intracellular part

extracellular organelle
type: Class
equivalent class: Class
  intersection of: organelle
  intersection of: Restriction
    on property: part_of
    some values from: extracellular region
subclass of: organelle
subclass of: extracellular region part

intracellular membrane-bounded organelle
type: Class
subclass of: membrane-bounded organelle
subclass of: intracellular organelle

intracellular non-membrane-bounded organelle
type: Class
equivalent class: Class
  intersection of: non-membrane-bounded organelle
  intersection of: Restriction
    on property: part_of
    some values from: intracellular
subclass of: non-membrane-bounded organelle
subclass of: intracellular organelle

protein complex
type: Class
subclass of: macromolecular complex

regulation of carbohydrate biosynthetic process
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: regulates
    some values from: carbohydrate biosynthetic process
subclass of: regulation of carbohydrate metabolic process
subclass of: regulation of biosynthetic process
subclass of: Restriction
  on property: regulates
  some values from: carbohydrate biosynthetic process

regulation of ion transport
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: regulates
    some values from: ion transport
subclass of: GO_0051049
subclass of: Restriction
  on property: regulates
  some values from: ion transport

positive regulation of ion transport
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: positively regulates
    some values from: ion transport
subclass of: regulation of ion transport
subclass of: GO_0051050
subclass of: Restriction
  on property: positively regulates
  some values from: ion transport

negative regulation of ion transport
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: negatively regulates
    some values from: ion transport
subclass of: regulation of ion transport
subclass of: GO_0051051
subclass of: Restriction
  on property: negatively regulates
  some values from: ion transport

contractile fiber
type: Class
subclass of: intracellular non-membrane-bounded organelle
subclass of: cytoplasmic part
subclass of: GO_0099512

oxoacid metabolic process
type: Class
subclass of: organic acid metabolic process

regulation of generation of precursor metabolites and energy
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: regulates
    some values from: generation of precursor metabolites and energy
subclass of: regulation of cellular metabolic process
subclass of: Restriction
  on property: regulates
  some values from: generation of precursor metabolites and energy

regulation of carbohydrate catabolic process
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: regulates
    some values from: carbohydrate catabolic process
subclass of: regulation of carbohydrate metabolic process
subclass of: regulation of catabolic process
subclass of: Restriction
  on property: regulates
  some values from: carbohydrate catabolic process

regulation of cellular carbohydrate catabolic process
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: regulates
    some values from: cellular carbohydrate catabolic process
subclass of: regulation of cellular carbohydrate metabolic process
subclass of: regulation of cellular catabolic process
subclass of: regulation of carbohydrate catabolic process
subclass of: GO_0060255
subclass of: Restriction
  on property: regulates
  some values from: cellular carbohydrate catabolic process

regulation of respiratory gaseous exchange
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: regulates
    some values from: respiratory gaseous exchange
subclass of: GO_0051239
subclass of: Restriction
  on property: regulates
  some values from: respiratory gaseous exchange

cellular amide metabolic process
type: Class
subclass of: cellular nitrogen compound metabolic process

amide biosynthetic process
type: Class
subclass of: cellular amide metabolic process
subclass of: cellular nitrogen compound biosynthetic process

regulation of multi-organism process
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: regulates
    some values from: GO_0051704
subclass of: regulation of biological process
subclass of: Restriction
  on property: regulates
  some values from: GO_0051704

negative regulation of multi-organism process
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: negatively regulates
    some values from: GO_0051704
subclass of: regulation of multi-organism process
subclass of: negative regulation of biological process
subclass of: Restriction
  on property: negatively regulates
  some values from: GO_0051704

positive regulation of multi-organism process
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: positively regulates
    some values from: GO_0051704
subclass of: regulation of multi-organism process
subclass of: positive regulation of biological process
subclass of: Restriction
  on property: positively regulates
  some values from: GO_0051704

glucan metabolic process
type: Class
subclass of: polysaccharide metabolic process

regulation of system process
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: regulates
    some values from: system process
subclass of: GO_0051239
subclass of: Restriction
  on property: regulates
  some values from: system process

regulation of digestive system process
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: regulates
    some values from: digestive system process
subclass of: regulation of system process
subclass of: Restriction
  on property: regulates
  some values from: digestive system process

regulation of endocrine process
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: regulates
    some values from: GO_0050886
subclass of: regulation of system process
subclass of: Restriction
  on property: regulates
  some values from: GO_0050886

regulation of excretion
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: regulates
    some values from: excretion
subclass of: regulation of system process
subclass of: GO_0051046
subclass of: Restriction
  on property: regulates
  some values from: excretion

regulation of respiratory system process
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: regulates
    some values from: respiratory system process
subclass of: regulation of respiratory gaseous exchange
subclass of: regulation of system process
subclass of: Restriction
  on property: regulates
  some values from: respiratory system process

regulation of anion transport
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: regulates
    some values from: anion transport
subclass of: regulation of ion transport
subclass of: Restriction
  on property: regulates
  some values from: anion transport

negative regulation of molecular function
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: negatively regulates
    some values from: molecular_function
subclass of: GO_0065009
subclass of: Restriction
  on property: negatively regulates
  some values from: molecular_function

positive regulation of molecular function
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: positively regulates
    some values from: molecular_function
subclass of: GO_0065009
subclass of: Restriction
  on property: positively regulates
  some values from: molecular_function

cellular metabolic process
type: Class
subclass of: metabolic process
subclass of: cellular process

primary metabolic process
type: Class
subclass of: metabolic process

cellular polysaccharide catabolic process
type: Class
subclass of: polysaccharide catabolic process
subclass of: cellular polysaccharide metabolic process
subclass of: cellular carbohydrate catabolic process

cellular catabolic process
type: Class
subclass of: catabolic process
subclass of: cellular metabolic process

cellular biosynthetic process
type: Class
subclass of: biosynthetic process
subclass of: cellular metabolic process

cellular macromolecule metabolic process
type: Class
subclass of: macromolecule metabolic process
subclass of: cellular metabolic process

cellular carbohydrate metabolic process
type: Class
subclass of: carbohydrate metabolic process
subclass of: cellular metabolic process

cellular polysaccharide metabolic process
type: Class
subclass of: polysaccharide metabolic process
subclass of: cellular macromolecule metabolic process
subclass of: cellular carbohydrate metabolic process

cellular nitrogen compound biosynthetic process
type: Class
subclass of: cellular nitrogen compound metabolic process
subclass of: cellular biosynthetic process

cellular carbohydrate catabolic process
type: Class
subclass of: carbohydrate catabolic process
subclass of: cellular catabolic process
subclass of: cellular carbohydrate metabolic process

small molecule metabolic process
type: Class
subclass of: metabolic process

small molecule biosynthetic process
type: Class
subclass of: biosynthetic process
subclass of: small molecule metabolic process

cell body
type: Class
subclass of: cell part

extracellular matrix component
type: Class
equivalent class: Class
  intersection of: cellular_component
  intersection of: Restriction
    on property: part_of
    some values from: extracellular matrix
subclass of: extracellular region part
subclass of: Restriction
  on property: part_of
  some values from: extracellular matrix

extracellular region part
type: Class
equivalent class: Class
  intersection of: cellular_component
  intersection of: Restriction
    on property: part_of
    some values from: extracellular region
subclass of: cellular_component
subclass of: Restriction
  on property: part_of
  some values from: extracellular region

organelle part
type: Class
equivalent class: Class
  intersection of: cellular_component
  intersection of: Restriction
    on property: part_of
    some values from: organelle
subclass of: cellular_component
subclass of: Restriction
  on property: part_of
  some values from: organelle

intracellular part
type: Class
equivalent class: Class
  intersection of: cellular_component
  intersection of: Restriction
    on property: part_of
    some values from: intracellular
subclass of: cell part
subclass of: Restriction
  on property: part_of
  some values from: intracellular

membrane part
type: Class
equivalent class: Class
  intersection of: cellular_component
  intersection of: Restriction
    on property: part_of
    some values from: membrane
subclass of: cellular_component
subclass of: Restriction
  on property: part_of
  some values from: membrane

nuclear part
type: Class
equivalent class: Class
  intersection of: cellular_component
  intersection of: Restriction
    on property: part_of
    some values from: nucleus
subclass of: intracellular organelle part
subclass of: Restriction
  on property: part_of
  some values from: nucleus

cytoskeletal part
type: Class
equivalent class: Class
  intersection of: cellular_component
  intersection of: Restriction
    on property: part_of
    some values from: cytoskeleton
subclass of: intracellular organelle part
subclass of: Restriction
  on property: part_of
  some values from: cytoskeleton

cytoplasmic vesicle part
type: Class
equivalent class: Class
  intersection of: cellular_component
  intersection of: Restriction
    on property: part_of
    some values from: cytoplasmic vesicle
subclass of: cytoplasmic part
subclass of: intracellular organelle part
subclass of: Restriction
  on property: part_of
  some values from: cytoplasmic vesicle

cytoplasmic part
type: Class
equivalent class: Class
  intersection of: cellular_component
  intersection of: Restriction
    on property: part_of
    some values from: cytoplasm
subclass of: intracellular part
subclass of: Restriction
  on property: part_of
  some values from: cytoplasm

intracellular organelle part
type: Class
subclass of: organelle part
subclass of: intracellular part
subclass of: Restriction
  on property: part_of
  some values from: intracellular organelle

contractile fiber part
type: Class
equivalent class: Class
  intersection of: cellular_component
  intersection of: Restriction
    on property: part_of
    some values from: contractile fiber
subclass of: organelle part
subclass of: cytoplasmic part
subclass of: Restriction
  on property: part_of
  some values from: contractile fiber

plasma membrane part
type: Class
equivalent class: Class
  intersection of: cellular_component
  intersection of: Restriction
    on property: part_of
    some values from: plasma membrane
subclass of: membrane part
subclass of: cell part
subclass of: Restriction
  on property: part_of
  some values from: plasma membrane

cell projection part
type: Class
equivalent class: Class
  intersection of: cellular_component
  intersection of: Restriction
    on property: part_of
    some values from: cell projection
subclass of: cell part
subclass of: Restriction
  on property: part_of
  some values from: cell projection

cell part
type: Class
equivalent class: Class
  intersection of: cellular_component
  intersection of: Restriction
    on property: part_of
    some values from: cell
subclass of: cellular_component
subclass of: Restriction
  on property: part_of
  some values from: cell

multi-organism reproductive process
type: Class
subclass of: reproductive process
subclass of: GO_0051704

multi-multicellular organism process
type: Class
subclass of: multicellular organismal process
subclass of: GO_0051704

plasma membrane fusion
type: Class
subclass of: GO_0061025

T cell selection
type: Class
subclass of: immune system process
subclass of: Restriction
  on property: part_of
  some values from: T cell differentiation

keratin filament
type: Class
subclass of: intermediate filament

intermediate filament cytoskeleton
type: Class
subclass of: cytoskeleton

establishment of protein localization
type: Class
subclass of: protein localization
subclass of: GO_0051234

leukocyte activation
type: Class
subclass of: cell activation
subclass of: immune system process

regulation of B cell differentiation
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: regulates
    some values from: B cell differentiation
subclass of: regulation of lymphocyte differentiation
subclass of: GO_0050864
subclass of: Restriction
  on property: regulates
  some values from: B cell differentiation

negative regulation of B cell differentiation
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: negatively regulates
    some values from: B cell differentiation
subclass of: regulation of B cell differentiation
subclass of: negative regulation of lymphocyte differentiation
subclass of: GO_0050869
subclass of: Restriction
  on property: negatively regulates
  some values from: B cell differentiation

positive regulation of B cell differentiation
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: positively regulates
    some values from: B cell differentiation
subclass of: regulation of B cell differentiation
subclass of: positive regulation of lymphocyte differentiation
subclass of: GO_0050871
subclass of: Restriction
  on property: positively regulates
  some values from: B cell differentiation

regulation of T cell differentiation
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: regulates
    some values from: T cell differentiation
subclass of: regulation of lymphocyte differentiation
subclass of: GO_0050863
subclass of: Restriction
  on property: regulates
  some values from: T cell differentiation

negative regulation of T cell differentiation
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: negatively regulates
    some values from: T cell differentiation
subclass of: regulation of T cell differentiation
subclass of: negative regulation of lymphocyte differentiation
subclass of: GO_0050868
subclass of: Restriction
  on property: negatively regulates
  some values from: T cell differentiation

positive regulation of T cell differentiation
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: positively regulates
    some values from: T cell differentiation
subclass of: regulation of T cell differentiation
subclass of: positive regulation of lymphocyte differentiation
subclass of: GO_0050870
subclass of: Restriction
  on property: positively regulates
  some values from: T cell differentiation

regulation of cell differentiation
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: regulates
    some values from: cell differentiation
subclass of: regulation of developmental process
subclass of: regulation of cellular process
subclass of: Restriction
  on property: regulates
  some values from: cell differentiation

negative regulation of cell differentiation
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: negatively regulates
    some values from: cell differentiation
subclass of: regulation of cell differentiation
subclass of: negative regulation of cellular process
subclass of: GO_0051093
subclass of: Restriction
  on property: negatively regulates
  some values from: cell differentiation

positive regulation of cell differentiation
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: positively regulates
    some values from: cell differentiation
subclass of: regulation of cell differentiation
subclass of: positive regulation of cellular process
subclass of: GO_0051094
subclass of: Restriction
  on property: positively regulates
  some values from: cell differentiation

regulation of lymphocyte differentiation
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: regulates
    some values from: lymphocyte differentiation
subclass of: GO_0051249
subclass of: GO_1902105
subclass of: Restriction
  on property: regulates
  some values from: lymphocyte differentiation

negative regulation of lymphocyte differentiation
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: negatively regulates
    some values from: lymphocyte differentiation
subclass of: regulation of lymphocyte differentiation
subclass of: GO_0051250
subclass of: GO_1902106
subclass of: Restriction
  on property: negatively regulates
  some values from: lymphocyte differentiation

positive regulation of lymphocyte differentiation
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: positively regulates
    some values from: lymphocyte differentiation
subclass of: regulation of lymphocyte differentiation
subclass of: GO_0051251
subclass of: GO_1902107
subclass of: Restriction
  on property: positively regulates
  some values from: lymphocyte differentiation

negative regulation of glycogen biosynthetic process
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: negatively regulates
    some values from: glycogen biosynthetic process
subclass of: regulation of glycogen biosynthetic process
subclass of: GO_0070874
subclass of: GO_2000113
subclass of: Restriction
  on property: negatively regulates
  some values from: glycogen biosynthetic process

positive regulation of glycogen biosynthetic process
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: positively regulates
    some values from: glycogen biosynthetic process
subclass of: regulation of glycogen biosynthetic process
subclass of: positive regulation of macromolecule biosynthetic process
subclass of: positive regulation of cellular biosynthetic process
subclass of: GO_0070875
subclass of: Restriction
  on property: positively regulates
  some values from: glycogen biosynthetic process

regulation of angiogenesis
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: regulates
    some values from: angiogenesis
subclass of: regulation of anatomical structure morphogenesis
subclass of: GO_1901342
subclass of: Restriction
  on property: regulates
  some values from: angiogenesis

positive regulation of angiogenesis
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: positively regulates
    some values from: angiogenesis
subclass of: regulation of angiogenesis
subclass of: GO_1904018
subclass of: Restriction
  on property: positively regulates
  some values from: angiogenesis

positive regulation of ossification
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: positively regulates
    some values from: ossification
subclass of: regulation of ossification
subclass of: GO_0051240
subclass of: Restriction
  on property: positively regulates
  some values from: ossification

positive regulation of cell adhesion
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: positively regulates
    some values from: cell adhesion
subclass of: regulation of cell adhesion
subclass of: positive regulation of biological process
subclass of: Restriction
  on property: positively regulates
  some values from: cell adhesion

negative regulation of glycogen catabolic process
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: negatively regulates
    some values from: glycogen catabolic process
subclass of: regulation of glycogen catabolic process
subclass of: negative regulation of cellular catabolic process
subclass of: GO_0070874
subclass of: Restriction
  on property: negatively regulates
  some values from: glycogen catabolic process

positive regulation of glycogen catabolic process
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: positively regulates
    some values from: glycogen catabolic process
subclass of: regulation of glycogen catabolic process
subclass of: positive regulation of cellular catabolic process
subclass of: GO_0070875
subclass of: Restriction
  on property: positively regulates
  some values from: glycogen catabolic process

negative regulation of heart contraction
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: negatively regulates
    some values from: GO_0060047
subclass of: regulation of heart contraction
subclass of: GO_1903523
subclass of: Restriction
  on property: negatively regulates
  some values from: GO_0060047

positive regulation of heart contraction
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: positively regulates
    some values from: GO_0060047
subclass of: regulation of heart contraction
subclass of: GO_1903524
subclass of: Restriction
  on property: positively regulates
  some values from: GO_0060047

negative regulation of lipid metabolic process
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: negatively regulates
    some values from: lipid metabolic process
subclass of: negative regulation of metabolic process
subclass of: regulation of lipid metabolic process
subclass of: Restriction
  on property: negatively regulates
  some values from: lipid metabolic process

positive regulation of lipid metabolic process
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: positively regulates
    some values from: lipid metabolic process
subclass of: positive regulation of metabolic process
subclass of: regulation of lipid metabolic process
subclass of: Restriction
  on property: positively regulates
  some values from: lipid metabolic process

negative regulation of carbohydrate metabolic process
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: negatively regulates
    some values from: carbohydrate metabolic process
subclass of: regulation of carbohydrate metabolic process
subclass of: negative regulation of metabolic process
subclass of: Restriction
  on property: negatively regulates
  some values from: carbohydrate metabolic process

positive regulation of carbohydrate metabolic process
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: positively regulates
    some values from: carbohydrate metabolic process
subclass of: regulation of carbohydrate metabolic process
subclass of: positive regulation of metabolic process
subclass of: Restriction
  on property: positively regulates
  some values from: carbohydrate metabolic process

negative regulation of exocytosis
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: negatively regulates
    some values from: exocytosis
subclass of: regulation of exocytosis
subclass of: GO_1903531
subclass of: Restriction
  on property: negatively regulates
  some values from: exocytosis

positive regulation of exocytosis
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: positively regulates
    some values from: exocytosis
subclass of: regulation of exocytosis
subclass of: GO_1903532
subclass of: Restriction
  on property: positively regulates
  some values from: exocytosis

negative regulation of muscle contraction
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: negatively regulates
    some values from: muscle contraction
subclass of: regulation of muscle contraction
subclass of: GO_0051241
subclass of: Restriction
  on property: negatively regulates
  some values from: muscle contraction

positive regulation of muscle contraction
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: positively regulates
    some values from: muscle contraction
subclass of: regulation of muscle contraction
subclass of: GO_0051240
subclass of: Restriction
  on property: positively regulates
  some values from: muscle contraction

negative regulation of steroid metabolic process
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: negatively regulates
    some values from: steroid metabolic process
subclass of: regulation of steroid metabolic process
subclass of: negative regulation of lipid metabolic process
subclass of: Restriction
  on property: negatively regulates
  some values from: steroid metabolic process

positive regulation of steroid metabolic process
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: positively regulates
    some values from: steroid metabolic process
subclass of: regulation of steroid metabolic process
subclass of: positive regulation of lipid metabolic process
subclass of: Restriction
  on property: positively regulates
  some values from: steroid metabolic process

negative regulation of smooth muscle contraction
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: negatively regulates
    some values from: smooth muscle contraction
subclass of: regulation of smooth muscle contraction
subclass of: negative regulation of muscle contraction
subclass of: Restriction
  on property: negatively regulates
  some values from: smooth muscle contraction

positive regulation of smooth muscle contraction
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: positively regulates
    some values from: smooth muscle contraction
subclass of: regulation of smooth muscle contraction
subclass of: positive regulation of muscle contraction
subclass of: Restriction
  on property: positively regulates
  some values from: smooth muscle contraction

negative regulation of striated muscle contraction
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: negatively regulates
    some values from: striated muscle contraction
subclass of: regulation of striated muscle contraction
subclass of: negative regulation of muscle contraction
subclass of: Restriction
  on property: negatively regulates
  some values from: striated muscle contraction

positive regulation of striated muscle contraction
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: positively regulates
    some values from: striated muscle contraction
subclass of: regulation of striated muscle contraction
subclass of: positive regulation of muscle contraction
subclass of: Restriction
  on property: positively regulates
  some values from: striated muscle contraction

negative regulation of embryonic development
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: negatively regulates
    some values from: embryo development
subclass of: regulation of embryonic development
subclass of: GO_0051093
subclass of: GO_0051241
subclass of: Restriction
  on property: negatively regulates
  some values from: embryo development

regulation of embryonic development
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: regulates
    some values from: embryo development
subclass of: GO_2000026
subclass of: Restriction
  on property: regulates
  some values from: embryo development

carboxylic acid biosynthetic process
type: Class
subclass of: organic acid biosynthetic process
subclass of: carboxylic acid metabolic process

heterocycle metabolic process
type: Class
subclass of: cellular metabolic process

saliva secretion
type: Class
subclass of: body fluid secretion
subclass of: digestive system process
subclass of: secretion by tissue

lymphocyte activation
type: Class
subclass of: leukocyte activation

lymphocyte proliferation
type: Class
subclass of: mononuclear cell proliferation
subclass of: lymphocyte activation

negative regulation of insulin secretion
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: negatively regulates
    some values from: insulin secretion
subclass of: negative regulation of protein secretion
subclass of: regulation of insulin secretion
subclass of: GO_0090278
subclass of: Restriction
  on property: negatively regulates
  some values from: insulin secretion

acid secretion
type: Class
subclass of: secretion

regulation of saliva secretion
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: regulates
    some values from: saliva secretion
subclass of: regulation of digestive system process
subclass of: GO_0050878
subclass of: GO_0051046
subclass of: Restriction
  on property: regulates
  some values from: saliva secretion

positive regulation of saliva secretion
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: positively regulates
    some values from: saliva secretion
subclass of: regulation of saliva secretion
subclass of: GO_0051047
subclass of: GO_0060456
subclass of: Restriction
  on property: positively regulates
  some values from: saliva secretion

hormone secretion
type: Class
subclass of: hormone transport
subclass of: signal release

regulation of hormone secretion
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: regulates
    some values from: hormone secretion
subclass of: regulation of cell communication
subclass of: regulation of hormone levels
subclass of: regulation of signaling
subclass of: GO_1903530
subclass of: Restriction
  on property: regulates
  some values from: hormone secretion

regulation of hormone biosynthetic process
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: regulates
    some values from: hormone biosynthetic process
subclass of: regulation of cellular biosynthetic process
subclass of: regulation of hormone metabolic process
subclass of: Restriction
  on property: regulates
  some values from: hormone biosynthetic process

positive regulation of hormone biosynthetic process
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: positively regulates
    some values from: hormone biosynthetic process
subclass of: positive regulation of cellular biosynthetic process
subclass of: positive regulation of hormone metabolic process
subclass of: regulation of hormone biosynthetic process
subclass of: Restriction
  on property: positively regulates
  some values from: hormone biosynthetic process

positive regulation of hormone secretion
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: positively regulates
    some values from: hormone secretion
subclass of: positive regulation of cell communication
subclass of: positive regulation of signaling
subclass of: regulation of hormone secretion
subclass of: GO_1903532
subclass of: Restriction
  on property: positively regulates
  some values from: hormone secretion

negative regulation of hormone secretion
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: negatively regulates
    some values from: hormone secretion
subclass of: negative regulation of cell communication
subclass of: negative regulation of signaling
subclass of: regulation of hormone secretion
subclass of: GO_1903531
subclass of: Restriction
  on property: negatively regulates
  some values from: hormone secretion

positive regulation of lipid biosynthetic process
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: positively regulates
    some values from: lipid biosynthetic process
subclass of: positive regulation of biosynthetic process
subclass of: positive regulation of lipid metabolic process
subclass of: regulation of lipid biosynthetic process
subclass of: Restriction
  on property: positively regulates
  some values from: lipid biosynthetic process

regulation of lipid biosynthetic process
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: regulates
    some values from: lipid biosynthetic process
subclass of: regulation of biosynthetic process
subclass of: regulation of lipid metabolic process
subclass of: Restriction
  on property: regulates
  some values from: lipid biosynthetic process

secretion
type: Class
subclass of: transport

carboxylic acid transport
type: Class
subclass of: organic anion transport
subclass of: organic acid transport

male gamete generation
type: Class
subclass of: gamete generation

sperm capacitation
type: Class
subclass of: developmental process involved in reproduction
subclass of: cellular process involved in reproduction in multicellular organism
subclass of: cell maturation
subclass of: Restriction
  on property: part_of
  some values from: spermatid development

norepinephrine secretion
type: Class
subclass of: norepinephrine transport
subclass of: catecholamine secretion

organelle fusion
type: Class
subclass of: organelle organization

mesoderm morphogenesis
type: Class
subclass of: tissue morphogenesis
subclass of: Restriction
  on property: part_of
  some values from: mesoderm development

cell development
type: Class
subclass of: anatomical structure development
subclass of: cellular developmental process
subclass of: Restriction
  on property: part_of
  some values from: cell differentiation

cell maturation
type: Class
subclass of: developmental maturation
subclass of: cellular developmental process
subclass of: Restriction
  on property: part_of
  some values from: cell development

oogenesis
type: Class
subclass of: germ cell development
subclass of: female gamete generation

animal organ development
type: Class
subclass of: anatomical structure development
subclass of: Restriction
  on property: part_of
  some values from: system development

blood vessel morphogenesis
type: Class
subclass of: anatomical structure morphogenesis
subclass of: Restriction
  on property: part_of
  some values from: blood vessel development

spermatid differentiation
type: Class
subclass of: developmental process involved in reproduction
subclass of: cellular process involved in reproduction in multicellular organism
subclass of: cell differentiation
subclass of: Restriction
  on property: part_of
  some values from: spermatogenesis

positive regulation of biological process
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: positively regulates
    some values from: biological_process
subclass of: regulation of biological process
subclass of: Restriction
  on property: positively regulates
  some values from: biological_process

negative regulation of biological process
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: negatively regulates
    some values from: biological_process
subclass of: regulation of biological process
subclass of: Restriction
  on property: negatively regulates
  some values from: biological_process

positive regulation of behavior
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: positively regulates
    some values from: behavior
subclass of: positive regulation of biological process
subclass of: regulation of behavior
subclass of: Restriction
  on property: positively regulates
  some values from: behavior

negative regulation of behavior
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: negatively regulates
    some values from: behavior
subclass of: negative regulation of biological process
subclass of: regulation of behavior
subclass of: Restriction
  on property: negatively regulates
  some values from: behavior

positive regulation of cellular process
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: positively regulates
    some values from: cellular process
subclass of: positive regulation of biological process
subclass of: regulation of cellular process
subclass of: Restriction
  on property: positively regulates
  some values from: cellular process

negative regulation of cellular process
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: negatively regulates
    some values from: cellular process
subclass of: negative regulation of biological process
subclass of: regulation of cellular process
subclass of: Restriction
  on property: negatively regulates
  some values from: cellular process

hematopoietic or lymphoid organ development
type: Class
subclass of: animal organ development
subclass of: Restriction
  on property: part_of
  some values from: immune system development

regulation of post-embryonic development
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: regulates
    some values from: post-embryonic development
subclass of: GO_2000026
subclass of: Restriction
  on property: regulates
  some values from: post-embryonic development

negative regulation of post-embryonic development
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: negatively regulates
    some values from: post-embryonic development
subclass of: regulation of post-embryonic development
subclass of: GO_0051093
subclass of: GO_0051241
subclass of: Restriction
  on property: negatively regulates
  some values from: post-embryonic development

positive regulation of post-embryonic development
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: positively regulates
    some values from: post-embryonic development
subclass of: regulation of post-embryonic development
subclass of: GO_0051094
subclass of: GO_0051240
subclass of: Restriction
  on property: positively regulates
  some values from: post-embryonic development

regulation of response to stimulus
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: regulates
    some values from: GO_0050896
subclass of: regulation of biological process
subclass of: Restriction
  on property: regulates
  some values from: GO_0050896

positive regulation of response to stimulus
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: positively regulates
    some values from: GO_0050896
subclass of: positive regulation of biological process
subclass of: regulation of response to stimulus
subclass of: Restriction
  on property: positively regulates
  some values from: GO_0050896

negative regulation of response to stimulus
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: negatively regulates
    some values from: GO_0050896
subclass of: negative regulation of biological process
subclass of: regulation of response to stimulus
subclass of: Restriction
  on property: negatively regulates
  some values from: GO_0050896

embryonic morphogenesis
type: Class
subclass of: anatomical structure morphogenesis
subclass of: Restriction
  on property: part_of
  some values from: embryo development

multicellular organismal reproductive process
type: Class
subclass of: reproductive process
subclass of: Restriction
  on property: part_of
  some values from: multicellular organism reproduction

anatomical structure formation involved in morphogenesis
type: Class
subclass of: developmental process
subclass of: Restriction
  on property: part_of
  some values from: anatomical structure morphogenesis

generation of neurons
type: Class
subclass of: neurogenesis

tissue morphogenesis
type: Class
subclass of: anatomical structure morphogenesis
subclass of: Restriction
  on property: part_of
  some values from: tissue development

system development
type: Class
subclass of: anatomical structure development
subclass of: Restriction
  on property: part_of
  some values from: multicellular organism development

gland development
type: Class
subclass of: animal organ development

branching morphogenesis of an epithelial tube
type: Class
subclass of: tube morphogenesis
subclass of: GO_0061138
subclass of: Restriction
  on property: part_of
  some values from: GO_0060562

pigment granule
type: Class
subclass of: cytoplasmic vesicle

anatomical structure development
type: Class
subclass of: developmental process

cellular developmental process
type: Class
subclass of: cellular process
subclass of: developmental process

cell motility
type: Class
subclass of: movement of cell or subcellular component
subclass of: locomotion
subclass of: Restriction
  on property: part_of
  some values from: GO_0051674

multicellular organismal homeostasis
type: Class
subclass of: multicellular organismal process
subclass of: homeostatic process

chemical homeostasis
type: Class
subclass of: homeostatic process

catecholamine secretion
type: Class
subclass of: secretion by cell
subclass of: GO_0051937

regulation of catecholamine secretion
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: regulates
    some values from: catecholamine secretion
subclass of: GO_0051952
subclass of: GO_1903530
subclass of: Restriction
  on property: regulates
  some values from: catecholamine secretion

regulation of lymphocyte proliferation
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: regulates
    some values from: lymphocyte proliferation
subclass of: regulation of mononuclear cell proliferation
subclass of: GO_0051249
subclass of: Restriction
  on property: regulates
  some values from: lymphocyte proliferation

positive regulation of lymphocyte proliferation
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: positively regulates
    some values from: lymphocyte proliferation
subclass of: positive regulation of mononuclear cell proliferation
subclass of: regulation of lymphocyte proliferation
subclass of: GO_0051251
subclass of: Restriction
  on property: positively regulates
  some values from: lymphocyte proliferation

negative regulation of lymphocyte proliferation
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: negatively regulates
    some values from: lymphocyte proliferation
subclass of: negative regulation of mononuclear cell proliferation
subclass of: regulation of lymphocyte proliferation
subclass of: GO_0051250
subclass of: Restriction
  on property: negatively regulates
  some values from: lymphocyte proliferation

regulation of protein secretion
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: regulates
    some values from: protein secretion
subclass of: regulation of peptide secretion
subclass of: GO_0051223
subclass of: GO_1903530
subclass of: Restriction
  on property: regulates
  some values from: protein secretion

negative regulation of protein secretion
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: negatively regulates
    some values from: protein secretion
subclass of: negative regulation of peptide secretion
subclass of: regulation of protein secretion
subclass of: GO_0051224
subclass of: GO_1903531
subclass of: Restriction
  on property: negatively regulates
  some values from: protein secretion

positive regulation of protein secretion
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: positively regulates
    some values from: protein secretion
subclass of: positive regulation of peptide secretion
subclass of: regulation of protein secretion
subclass of: GO_0051222
subclass of: GO_1903532
subclass of: Restriction
  on property: positively regulates
  some values from: protein secretion

regulation of neurogenesis
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: regulates
    some values from: neurogenesis
subclass of: GO_0051960
subclass of: GO_0060284
subclass of: Restriction
  on property: part_of
  some values from: generation of neurons
subclass of: Restriction
  on property: regulates
  some values from: neurogenesis

negative regulation of neurogenesis
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: negatively regulates
    some values from: neurogenesis
subclass of: negative regulation of cell development
subclass of: regulation of neurogenesis
subclass of: GO_0051961
subclass of: Restriction
  on property: negatively regulates
  some values from: neurogenesis

positive regulation of neurogenesis
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: positively regulates
    some values from: neurogenesis
subclass of: positive regulation of cell development
subclass of: regulation of neurogenesis
subclass of: GO_0051962
subclass of: Restriction
  on property: positively regulates
  some values from: neurogenesis

regulation of immune response
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: regulates
    some values from: immune response
subclass of: regulation of immune system process
subclass of: regulation of response to stimulus
subclass of: Restriction
  on property: regulates
  some values from: immune response

negative regulation of immune response
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: negatively regulates
    some values from: immune response
subclass of: negative regulation of immune system process
subclass of: negative regulation of response to stimulus
subclass of: regulation of immune response
subclass of: Restriction
  on property: negatively regulates
  some values from: immune response

positive regulation of immune response
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: positively regulates
    some values from: immune response
subclass of: positive regulation of immune system process
subclass of: positive regulation of response to stimulus
subclass of: regulation of immune response
subclass of: Restriction
  on property: positively regulates
  some values from: immune response

regulation of biological process
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: regulates
    some values from: biological_process
subclass of: GO_0065007
subclass of: Restriction
  on property: regulates
  some values from: biological_process

regulation of developmental process
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: regulates
    some values from: developmental process
subclass of: regulation of biological process
subclass of: Restriction
  on property: regulates
  some values from: developmental process

regulation of cellular process
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: regulates
    some values from: cellular process
subclass of: regulation of biological process
subclass of: Restriction
  on property: regulates
  some values from: cellular process

regulation of behavior
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: regulates
    some values from: behavior
subclass of: regulation of biological process
subclass of: Restriction
  on property: regulates
  some values from: behavior

regulation of insulin secretion
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: regulates
    some values from: insulin secretion
subclass of: regulation of protein secretion
subclass of: GO_0090276
subclass of: Restriction
  on property: regulates
  some values from: insulin secretion

ion homeostasis
type: Class
subclass of: chemical homeostasis

regulation of steroid biosynthetic process
type: Class
equivalent class: Class
  intersection of: biological_process
  intersection of: Restriction
    on property: regulates
    some values from: steroid biosynthetic process
subclass of: regulation of steroid metabolic process
subclass of: regulation of lipid biosynthetic process
subclass of: Restriction
  on property: regulates
  some values from: steroid biosynthetic process

coagulation
type: Class
subclass of: multicellular organismal process

regulation of coagulation
type: Class
equivalent class: Class
  intersection of: biological_process
subclass of: GO_0051239