tuft cell of colon
tuft cell of colon
A tuft cell that is part of the colonic epithelium, primarily adapted for microbial sensing in the dense colonic microbiota. Unlike its small intestinal counterpart, it does not participate in parasite-driven tuft cell–ILC2 circuits. Instead, it detects bacterial metabolites via taste-signaling pathways (Strine and Craig, 2022). The colonic tuft cell plays a key role in epithelial repair, modulates inflammatory responses through IL-25 secretion, and contributes to intestinal homeostasis by balancing microbiome interactions (Sebastian et al., 2021).