inner wall Schlemm's canal endothelial cell
inner wall schlemm's canal endothelial cell
A Schlemm's canal endothelial cell that lines the inner wall of the Schlemm's canal. This cell exhibits a cobblestone appearance due to the significant biomechanical load it experiences, as well as the segmental flow of aqueous humor. The degree of biomechanical stress can lead to the formation of dome-like outpouchings known as giant vacuoles. In addition, the cell contains transcellular pores that mediate aqueous humor transport (Dautriche et al., 2015). This endothelial cell also displays prominent peripheral F-actin bands which help maintain structural integrity under pressure (Ethier et al., 2004).