Autologous Anti-IL-1RAP CAR T-cells CCTx-001
autologous anti-il-1rap car t-cells cctx-001
A preparation of autologous CD4+ and CD8+ T-lymphocytes that have been transduced to express a chimeric antigen receptor (CAR) consisting of an anti-interleukin-1 receptor accessory protein (IL-1RAP; IL-1 receptor 3; IL-1R3) single chain variable fragment (scFv) coupled to the hinge domain of human immunoglobulin G1 (IgG1), the co-stimulatory signaling domain CD28, the signaling domain of 4-1BB (CD137), and the zeta chain of the T-cell receptor (TCR)/CD3 complex (CD3zeta), with potential immunostimulating and antineoplastic activities. Upon administration, autologous anti-IL-1RAP CAR T-cells CCTx-001 specifically recognize and kill IL-1RAP-expressing tumor cells. IL-1RAP, a transmembrane glycoprotein, is highly expressed on leukemic cells but not on healthy hematopoietic stem and progenitor cells (HSPCs); its expression has been correlated with poor prognosis.