Allogeneic Regulatory T-cells TRX103
allogeneic regulatory t-cells trx103
A preparation of off-the-shelf (OTS), allogeneic CD4+ cells engineered to mimic regulatory type 1 (Tr1) cells, with potential immunomodulating activity. Upon infusion of allogeneic regulatory T-cells TRX103, these cells secrete the immunomodulatory cytokine interleukin-10 (IL-10) and other cytokines upon exposure to donor T-cells, and may additionally stimulate the production of de novo Tr1 cells. This suppresses immune responses and resets the immune system. This may ultimately prevent or reduce graft versus host disease (GvHD). IL-10 plays a key role in controlling inflammation, downregulating immune responses, and inducing immunological tolerance. IL-10 induces both a long-lasting antigen specific T-cell anergy and the differentiation of Tr1 cells.