quiescent fibroblast
quiescent fibroblast
A fibroblast in a quiescent state, characterized by a smaller, spindle-shaped morphology with a relatively small cytoplasm, modest rough endoplasmic reticulum and condensed chromatin. Despite low proliferation and contractility, it maintains high metabolic activity for extracellular-matrix homeostasis through continuous matrix protein turnover and mechanosensitive signaling. This cell can rapidly differentiate into contractile myofibroblasts under injury or inflammatory cues to drive tissue repair.