candoxatrilat
candoxatrilat
A dicarboxylic acid monoamide obtained by formal condensation between the amino group of <em>cis</em>-4-aminocyclohexanecarboxylic acid and the cyclopentanecarboxylic acid group of 1-[(2<i>S</i>)-2-carboxy-3-(2-methoxyethoxy)propyl]cyclopentanecarboxylic acid. A potent inhibitor of neutral endopeptidase (NEP, neprilysin, EC 3.4.24.11), it is used as its 2,3-dihydro-1<em>H</em>-inden-5-yl ester prodrug in the treatment of chronic heart failure.