cortistatins
cortistatins
Any member of a class of steroidal alkaloids obtained from the marine sponge <em>Corticium simplex</em>, with a basic skeleton that is (5R,8β)-5,8-epoxy-9,19-cyclo-9,10-secoandrostane, bearing a dimethylamino substituent at position 3 and an isoquinolin-7-yl or isoquinolin-7-yl-derived substituent at position 17. They selectively inhibit proliferation of human umbilical vein endothelial cells (HUVECs).