AMG-925
amg-925
An organic heterotricyclic compound that is 9<em>H</em>-pyrido[4',3':4,5]pyrrolo[2,3-<em>d</em>]pyrimidine which is substituted by a [6-(hydroxyacetyl)-5,6,7,8-tetrahydro-1,6-naphthyridin-2-yl]nitrilo group at position 2 and by a <i>trans</i>-4-methylcyclohexyl group at position 9. It is a FLT3 and CDK4 dual kinase inhibitor that has antineoplastic activity. Currently under clinical investigation in patients with relapsed or refractory acute myeloid leukemia (AML).