ODN 2216
odn 2216
ODN 2216 is a human-specific TLR9 (toll-like receptor 9) ligand or agonist. ODN 2216 induces high amounts of IFN-a and IFN-b. ODN2216 induces IFN-a by pDC (plasmacytoid DC) and IL-12 (p40) production by DC (dendritic cells). ODN 2216 stimulates IFN-y production in peripheral blood mononuclear cells (PBMC), which is indirect and mediated by IFN-a/b. ODN 2216 can activate NK cells and promote IFN-y production of TCR-triggered CD4+ T cells. (MedChemExpress)