doxacurium chloride
doxacurium chloride
The dichloride salt of doxacurium. It is a mixture of the (1<i>R</i>,2<i>S</i>,1'<i>S</i>,2'<i>R</i>), (1<i>R</i>,2<i>S</i>,1'<i>R</i>,2'<i>S</i>) and (1<i>S</i>,2<i>R</i>,1'<i>S</i>,2'<i>R</i>) stereoisomers (a <em>meso</em> isomer and two enantiomers, respectively) of 2,2'-[(1,4-dioxobutane-1,4-diyl)bis(oxypropane-3,1-diyl)]bis[6,7,8-trimethoxy-2-methyl-1-(3,4,5-trimethoxybenzyl)-1,2,3,4-tetrahydroisoquinolinium] dichloride, all of which are in a <em>trans</em> configuration at the 1 and 2 positions of the tetrahydroisoquinolinium rings. A competitive neuromuscular blocker, it is used to provide muscle relaxation in general anaesthesia and to facilitate mechanical ventilation in patients in intensive care.