NPD6433
npd6433
An indolyl carboxylate ester that is 1<em>H</em>-indole substituted by methoxycarbonyl and (<i>E</i>)-(8-oxo-1,5,6,8-tetrahydro-2<em>H</em>-1,5-methanopyrido[1,2-<em>a</em>][1,5]diazocin-3(4<em>H</em>)-yl)diazenyl groups at positions 2 and 3, respectively. It targets the enoyl reductase domain of fungal fatty acid synthase, exhibits broad-spectrum antifungal activity, is bioactive against the filamentous mold, <em>Aspergillus fumigatus</em> and has minimal mammalian cytotoxicity.