papulacandin
papulacandin
Any of the carbohydrate-containing antibiotic compounds obtained from the deuteromycetous fungus <em>Papularia sphaerosperma</em> and generally consisting of <em>o</em>-orsellinic acid linked via a spirocyclic structure to a lactose moiety with two different side-chains: a shorter fatty-acid chain at the <em>O</em>-(6') position and a longer side-chain at the <em>O</em>-(3) position of the glucose moiety. Papulacandin D, the simplest member of the papulacandin family, lacks the <em>O</em>-(6'-acyl-β-galactoside) at the <em>O</em>-(4) position of the glucose residue. The papulacandins show potent antifungal activity against <em>Candida albicans</em>, <em>Geotrichum lactis</em>, <em>Saccharomyces cerevisiae</em>, and <em>Pneumocytis carinii</em>, but are inactive against filamentous fungi, bacteria, and protazoa.