label: Acquired Amegakaryocytic Thrombocytopenia
label_lc: acquired amegakaryocytic thrombocytopenia
description: A rare bone marrow disorder characterized by a marked decrease or complete absence of megakaryocytes with preservation of all other hematopoietic cell lineages. Causes include toxins, viruses, drugs, and humoral and cell-mediated suppression of megakaryocytopoeisis. It usually presents with bleeding, severe thrombocytopenia, and absence of splenomegaly. It is often misdiagnosed as immune thrombocytopenic purpura (ITP).