label: palmoplantar keratoderma-esophageal carcinoma syndrome
label_lc: palmoplantar keratoderma-esophageal carcinoma syndrome
description: An inherited condition characterized by palmoplantar keratoderma and esophageal cancer. The palmoplantar keratoderma usually begins around age 10, and esophageal cancer may form after age 20. This condition is caused by a mutation in the RHBDF2 gene and is inherited in an autosomal dominant pattern.