label: Vulvar Paget Disease
label_lc: vulvar paget disease
description: An uncommon intraepithelial malignant neoplasm of eccrine or apocrine origin, arising from the vulva.  It usually affects post-menopausal women.  In approximately 10-20% of the cases there is an associated anorectal, or urothelial carcinoma or a skin appendage adenocarcinoma identified.  It presents as a red, eczematous lesion.  Microscopically, it is characterized by the presence of the typical Paget cells which are large, round cells with abundant pale cytoplasm and large nuclei with prominent nucleoli.