label: T-B+ severe combined immunodeficiency due to IL-7Ralpha deficiency
label_lc: t-b+ severe combined immunodeficiency due to il-7ralpha deficiency
description: A severe combined immunodeficiency that results from defective IL7R expression causes T-B+NK+ SCID. Loss of IL-7R function leads to the loss of an antiapoptotic signal, resulting in a loss of T-cell selection in thymus.