label: Leukoencephalopathy with Brainstem and Spinal Cord Involvement and Lactate Elevation
label_lc: leukoencephalopathy with brainstem and spinal cord involvement and lactate elevation
description: An autosomal recessive condition caused by mutation(s) in the DARS2 gene, encoding aspartate--tRNA ligase, mitochondrial. It is characterized by slowly developing progressive cerebellar ataxia, spasticity, dorsal column dysfunction, and may also include a mild cognitive deficit or decline.