label: Succinate Dehydrogenase-Deficient Tumor Syndrome
label_lc: succinate dehydrogenase-deficient tumor syndrome
description: An autosomal dominant hereditary neoplastic syndrome caused by mutations in the SDHA,SDHB, SDHC, SDHD, and SDHAF2 genes. It is characterized by the development of paragangliomas and pheochromocytomas, gastrointestinal stromal tumors, and SDH-deficient renal cell carcinomas.