label: Nipple Paget Disease
label_lc: nipple paget disease
description: A malignant epithelial cellular proliferation characterized by the presence of atypical cells with large nuclei and abundant pale cytoplasm within the squamous epithelium of the nipple.  In almost all cases there is an underlying intraductal breast carcinoma or intraductal and invasive carcinoma.  The skin changes range from redness to eczematous appearance.