label: cobblestone lissencephaly without muscular or ocular involvement
label_lc: cobblestone lissencephaly without muscular or ocular involvement
description: Cobblestone lissencephaly without muscular or ocular involvement is a form of cobblestone lissencephaly characterized by a constellation of brain malformations which can either exist alone or in conjunction with minimal muscular and ocular abnormalities. The clinical features of the disease include severe developmental delay, increased head circumference, hydrocephalus and seizures.