label: Acute Promyelocytic Leukemia with t(15;17)(q24.1;q21.2); PML-RARA
label_lc: acute promyelocytic leukemia with t(15;17)(q24.1;q21.2); pml-rara
description: An acute promyelocytic leukemia characterized by the reciprocal balanced translocation t(15;17)(q24.1;q21.2) that results in the fusion of the promyelocytic leukemia (PML) gene and retinoic acid receptor-α (RARA) gene. The t(15;17)(q24.1;q21.2) with the resulting PML-RARA fusion gene occurs in over 95% of cases of acute promyelocytic leukemia. The remainder of the cases show variant RARA gene translocations with other genes.