label: Malignant Lymphoma, Large Cell, Cleaved and Non-Cleaved
label_lc: malignant lymphoma, large cell, cleaved and non-cleaved
description: Antiquated term describing follicular (nodular) or diffuse non-Hodgkin lymphomas that are composed of a mixture of large cells: large cleaved cells, with irregular nuclei without visible nucleoli; and large non-cleaved cells (centroblasts), having a rounder nucleus with two to three small, peripherally placed nucleoli and a small amount of basophilic cytoplasm.  The follicular variants represent mature B-cell lymphomas, whereas the diffuse variants can be either mature B- or mature T-cell lymphomas.