label: CAR T-cell-Related Hemophagocytic Lymphohistiocytosis-like Syndrome
label_lc: car t-cell-related hemophagocytic lymphohistiocytosis-like syndrome
description: A group of rare but severe toxicities resembling hemophagocytic lymphohistiocytosis (HLH) that present in a subset of patients with cytokine release syndrome (CRS) following chimeric antigen receptor (CAR) T-cell therapy. Characteristic findings may include hyperferritinemia, hypertriglyceridemia, hypofibrinogenemia, coagulopathy, hepatic transaminitis, hyperbilirubinemia, neutropenia, elevated lactate dehydrogenase, and occasionally hemophagocytosis.