label: ALK-Positive Lung Non-Small Cell Carcinoma
label_lc: alk-positive lung non-small cell carcinoma
description: A lung non-small cell carcinoma (NSCLC) characterized by the presence of rearrangements of the ALK gene that lead to activation of ALK kinase and ALK driven tumor formation. These rearrangements were initially identified as EML4-ALK fusions, but a variety of other ALK gene fusions were subsequently identified. Approximately 5% of patients with NSCLC carry ALK rearrangements and are highly sensitive to treatment with ALK inhibitors.