label: hyperkeratosis-hyperpigmentation syndrome
label_lc: hyperkeratosis-hyperpigmentation syndrome
description: Hyperkeratosis-hyperpigmentation syndrome describes a very rare hyperpigmentation of the skin characterized by tiny hyperpigmented spots mainly on skin exposed to sunlight, together with mild punctate palmoplantar papular hyperkeratosis as a major feature. There have been no further descriptions in the literature since 1993.