label: sterile multifocal osteomyelitis with periostitis and pustulosis
label_lc: sterile multifocal osteomyelitis with periostitis and pustulosis
description: An autoinflammatory disease caused by mutations in the IL1RN gene, which encodes the IL1 receptor antagonist. It presents in infancy, and is characterized by systemic inflammation, pustular rash, bone pain, sterile osteitis, and periostitis.