label: Dihydropyrimidine Dehydrogenase Deficiency
label_lc: dihydropyrimidine dehydrogenase deficiency
description: A rare disorder characterized by an inborn error in pyrimidine metabolism. It results in the deficiency or complete absence of the enzyme dihydropyrimidine dehydrogenase. Individuals with this disorder may develop a severe toxicity reaction if they are exposed to the chemotherapeutic agent 5-fluorouracil.