label: early-onset progressive neurodegeneration-blindness-ataxia-spasticity syndrome
label_lc: early-onset progressive neurodegeneration-blindness-ataxia-spasticity syndrome
description: Early-onset progressive neurodegeneration-blindness-ataxia-spasticity syndrome is a genetic neurodegenerative disease characterized by normal early development followed by childhood onset optic atrophy with progressive vision loss and eventually blindness, followed by progressive neurological decline that typically includes cerebellar ataxia, nystagmus, dorsal column dysfunction (decreased vibration and position sense), spastic paraplegia and finally tetraparesis.