Dual oxidase maturation factor family
dual oxidase maturation factor family
The dual oxidase maturation factor genes (DUOXA1 and DUOXA2) are arranged head-to-head to and co-expressed with their respective dual oxidase genes (DUOX1 and DUOX2). The genomic rearrangement leading to linkage of ancient DUOX and DUOXA genes can be traced back before the divergence of echinoderms. Dual oxidase maturation factors allow ER-to-Golgi transition, maturation, and translocation to the plasma membrane of functional DUOXs.