Class I HDAC complexes
class i hdac complexes
HDAC1, 2 and 3 form the catalytic subunit of multiprotein complexes to mediate gene transcription although HDAC8 is fully active in isolation. HDAC1 and HDAC2 form the catalytic core of multiple corepressor complexes, including NuRD (nucleosome remodeling and deacetylase), Sin3 (switch intensive 3) CoREST (corepressor of RE1-silencing transcription) and MiDAC (mitotic deacetylase), while HDAC3 forms the key component of the SMRT/NCoR (silencing mediator of retinoic acid and thyroid hormone receptors/nuclear receptor corepressor) complex. As part of these complexes, the HDACs become maximally activated and are targeted to specific regions of chromatin.