Fibrinogen chains
fibrinogen chains
Fibrinogen is a hexameric coagulation factor containing 2 polypeptide chains encoded by each of the 3 fibrinogen genes (FGA, FGB, and FGG). These genes are clustered within a 65-kilobase region on human chromosome 4. During coagulation, fibrinogen is converted to fibrin via thrombin-mediated proteolytic cleavage.