Zinc fingers C2H2C-type
zinc fingers c2h2c-type
These genes encode proteins containing a CysCysHisHisCys (CCHHC) type zinc finger domain. The CCHHC-type zinc finger contains five absolutely conserved cysteine and histidine residues (rather than the more usual four) with the sequence C-P-x-P-G-C-x-G-x-G-H-x(7)-H-R-x(4)-C. The second histidine has been shown to coordinate Zn(II) along with the three cysteines residues. The first His plays a different role in stabilizing the structure, stacking between the metal-binding core and an aromatic residue that is relatively conserved. CCHHC-type zinc fingers form small compact structures that can sit entirely within the major groove of DNA (<a href='https://pubmed.ncbi.nlm.nih.gov/18073212/'>PMID: 18073212</a>),(<a href='https://pubmed.ncbi.nlm.nih.gov/24097990/'>PMID:  24097990</a>), (<a href='https://pubmed.ncbi.nlm.nih.gov/25098749/'>PMID: 25098749</a>), (<a href='https://pubmed.ncbi.nlm.nih.gov/26158299/'>PMID: 26158299</a>), (<a href='https://pubmed.ncbi.nlm.nih.gov/14744132/'>PMID: 14744132</a>).