Telomerase holoenzyme subunits
telomerase holoenzyme subunits
A reverse transcriptase complex that is essential for maintenance of telomeres. Catalytic subunit TERT and RNA template TERC are essential for telomerase activity, adding telomeric repeats (TTAGGG) at chromosome ends to compensate for the telomere loss that is caused by incomplete genome end replication Elongates the single-stranded G-rich 3' protruding ends of chromosomal DNA using TERC RNA as a template. WRAP53 (also known as TCAB1) binds to the CAB box in TERC and facilitates localization of the telomerase complex to Cajal bodies. In S-phase, telomerase holoenzyme complex is targeted from Cajal bodies to telomeres by binding of TERT to the shelterin subunit, ACD.