Gamma-aminobutyric acid type A receptor subunits
gamma-aminobutyric acid type a receptor subunits
The GABA A receptor (GABA AR) is an ionotropic receptor and ligand-gated ion channel. Its endogenous ligand is gamma-aminobutyric acid (GABA), the major inhibitory neurotransmitter in the central nervous system. Upon activation, the GABA A receptor selectively conducts Cl- through its pore, resulting in hyperpolarization of the neuron. This causes an inhibitory effect on neurotransmission by diminishing the chance of a successful action potential occurring. The reversal potential of the GABA A-mediated IPSP in normal solution is -70 mV, contrasting the GABA B IPSP.