TTT complex
ttt complex
In response to DNA damage, cells activate a complex signal transduction network called the DNA damage response (DDR).   TTI1 (Tel two-interacting protein 1) and TTI2 are highly conserved regulators of the DDR in mammals, protect cells from spontaneous DNA damage and are required for the establishment of the intra-S and G2/M checkpoints.    TTI1 and TTI2 exist in multiple complexes, including a 2-MDa complex with TEL2 (telomere maintenance 2), called the Triple T complex, and phosphoinositide-3-kinase-related protein kinases (PIKKs) such as ataxia telangiectasia-mutated (ATM). The components of the TTT complex are mutually dependent on each other, and act as critical regulators of PIKK abundance and checkpoint signaling.