2-arachidonoylglycerol hydrolases
2-arachidonoylglycerol hydrolases
The endocannabinoid 2-arachidonoylglycerol (2-AG) is a lipid mediator involved in various physiological processes. In response to neural activity, 2-AG is synthesized post-synaptically, then activates pre-synaptic type 1 cannabinoid recep  tors, resulting in transient and long-lasting reduction of neurotransmitter release. The signalling competence of 2-AG is tightly regulated by the balanced action between 'on demand' biosynthesis and degradation. The major enzymatic route for 2-AG inactivation in brain is via hydrolysis; three serine hydrolases (MGLL, BHD6 AND ABHD12) account for approx. 99% of brain 2-AG hydrolase activity.