Zinc fingers GRF-type
zinc fingers grf-type
These genes encode proteins that contain Glycine-arginine-phenylalanine (GRF)-type zinc fingers (GRF-ZFs), 45- to 50-residue domains with a conserved GRxF motif. GRF-ZFs are widely distributed throughout eukaryotes in proteins that are involved in DNA damage response (DDR), transcriptional regulation, and RNA metabolism. GRF-ZFs are nucleic acid interaction modules and in several cases these motifs have been shown to enhance enzymatic activity. This domain comprises a three-stranded anti-parallel β-sheet that folds into a crescent-shaped claw-like structure (5U6Z). A single bound Zn(2+) ion plays a central structural role in this domain, and is coordinated with tetrahedral geometry by a 'CHCC' sequence motif.