Large tumor suppressor kinase family
large tumor suppressor kinase family
LATS1 and LATS2 are serine/threonine kinases of the AGC subfamily, most closely related to the serine/threonine kinase 38 family (also known as nuclear Dbf2-related kinases or NDRs). The LATS family have emerged as central regulators of cell fate, by modulating the functions of numerous oncogenic or tumor suppressive effectors, including the canonical Hippo effectors YAP1/WWTR1 (YAP/TAZ), the Aurora mitotic kinase family, estrogen signaling and the tumor suppressive transcription factor p53.