Vitamin K epoxide reductase complex subunit 1 family
vitamin k epoxide reductase complex subunit 1 family
Vitamin K epoxide reductase is a crucial enzyme in blood coagulation and the target of the most commonly used oral anticoagulant warfarin. There are two isoforms of this enzyme encoded by VKORC1 and VKORC1L1. The proteins share ~50% amino acid sequence identity and catalyze both vitamin K epoxide reductase and vitamin K quinone reductase enzymatic activities.