Miro like atypical Rho GTPases
miro like atypical rho gtpases
Mitochondrial Rho proteins (Miro-1, Q8IXI2 [encoded by RHOT1] and Miro-2, Q8IXI1 [encoded by RHOT2]), are atypical Rho GTPases. They have a unique domain organisation, with tandem GTP-binding domains and two EF hand domains (PF00036), that may bind calcium. They are also larger than classical small GTPases. It has been proposed that they are involved in mitochondrial homeostasis and apoptosis.