Caspase-2 PIDDosome complex
caspase-2 piddosome complex
Caspase-2-driven apoptosis is elicited in blood cells failing cytokinesis and extra centrosomes are necessary to trigger this cell death. Activation of caspase-2 depends on the PIDDosome multi-protein complex, and priming of PIDD1 at extra centrosomes is necessary for pathway activation