CORVET complex
corvet complex
The CORVET tethering complex regulates early-endosomal tethering and shares several subunits with the HOPS complex that regulates late endosomal tethering. VPS11 acts as a molecular switch that binds either the CORVET complex specific TGFBRAP1, or HOPS specific VPS39/RILP thereby allowing selective targeting of these tethering complexes to early- or late endosomes to time fusion events in the endo/lysosomal pathway.