Canonical Notch ligands
canonical notch ligands
The canonical Notch ligands are members of the Delta/Serrate/Lag-1 (DSL) family of proteins. When they bind to Notch receptors this induces a conformational change (regulated intramembrane proteolysis) in the receptor, freeing its Notch intracellular domain (NICD). The NICD can then translocate to the nucleus and promote gene transcription.