Repulsive guidance molecule family
repulsive guidance molecule family
The repulsive guidance molecule (RGM) family function as co-receptors that enhance cellular responses to BMP ligands.   RGM family members are differentially expressed in a wide range of tissues, and have been suggested to have diverse biologic roles ranging from repulsive axonal guidance, neural tube closure, neuronal differentiation, cell survival, axonal regeneration after injury, immunity, inflammation, and iron homeostasis regulation.