PIK3C3 complex subunits
pik3c3 complex subunits
The Beclin1–class III phosphatidylinositol 3-kinase (PI3KC3) complex produces an autophagy-specific pool of phosphatidylinositol 3-phosphate (PI3P). Inhibition of the activity or loss of the lipid kinase components inhibits autophagy. BECN1 interacts with a number of proteins, forming multiple functionally distinct complexes, and this allows Beclin1 to respond to different signals regulating autophagy.