L-lactate dehydrogenase family
l-lactate dehydrogenase family
L-lactate dehydrogenase (LDH, EC1.1.1.27) is a key enzyme that catalyzes the interconversion of L-lactate and pyruvate with nicotinamide adenine dinucleotide (NAD+) as a coenzyme. This enzyme exists in a tetrameric form by combination of M (muscle, LDHA) and H (heart, LDHB) subunits in various proportions in different somatic tissues. There are five major tetrameric LDH complexes consisting of LDHA and/or LDHB subunits. Expression of LDHC, LDHAL6A and the intronless gene LDHAL6B is restricted to testes where they may play a role in spermatogenesis.