PHD finger proteins
phd finger proteins
The PHD finger was discovered in 1993 as a Cys 4 -His-Cys 3 motif in the plant homeodomain (hence PHD) proteins HAT3.1 in Arabidopsis thaliana and maize ZmHox1a. The PHD finger motif resembles the metal binding RING domain (Cys 3 -His-Cys 4 ) and FYVE domain. It occurs as a single finger, but often in clusters of two or three, and it also occurs together with other domains, such as the chromodomain and the bromodomain.