Soluble guanylate cyclases
soluble guanylate cyclases
Soluble guanylyl cyclase (sGC) is the only known receptor for nitric oxide, NO. It is soluble, i.e. completely intracellular. Most notably, this enzyme is involved in vasodilation. In humans, it is encoded by the genes GUCY1A1, GUCY1A2, GUCY1B2 and GUCY1B3.  It is classified under EC number 4.6.1.2.