Dual-specificity tyrosine-regulated kinase family
dual-specificity tyrosine-regulated kinase family
Dual-specificity tyrosine-regulated kinases (DYRKs) comprise a family of protein kinases within the CMGC group of the eukaryotic kinome. DYRK proteins are defined as dual-specificity protein kinases because they have phosphorylation activity on tyrosine, serine, and threonine residues, although the tyrosine phosphorylation activity is restricted to auto-phosphorylation.