Polo like kinase family
polo like kinase family
The Polo like kinases are a family of serine/threonine kinases characterized by the presence of an N-terminal protein kinase domain and a C-terminal polo-box domain (PBD) involved in substrate binding and regulation of kinase activity. The truncated protein kinase domain in PLK5 is predicted to be catalytically inactive but the protein retains important functions in neuron biology.