Polycomb repressive complex 2
polycomb repressive complex 2
The Polycomb Repressive Complex 2 (PRC2) is a key chromatin modifier involved in the maintenance of transcriptional silencing. The proteins encoded by EZH1 and EZH2 are the two paralogous enzymatic subunits of the complex and the proteins encoded by SUZ12 and EED are strictly required for their enzymatic activity. The RBBP4/7 paralogs, which are believed to contribute to nucleosome binding, are also part of other chromatin regulatory complexes.