Protein kinase N family
protein kinase n family
The protein kinase N (PKN) family of serine/threonine protein kinases belongs to the AGC subfamily of protein kinases and is closely related to the protein kinase C (PKC) family. The PKN catalytic domains share approximately 50% sequence identity with the PKC family members. However, the N-terminal regulatory regions are radically different between the PKN and PKC kinases. All PKN family members exhibit three unique polybasic coiled-coil homology region 1 (HR1)-domains (also called antiparallel coiled-coil (ACC)-domains), which confer binding and regulation by the Rho family of small GTPases as well as a lipid regulated autoinhibitory C2-like domain.