Serum/glucocorticoid regulated kinase family
serum/glucocorticoid regulated kinase family
The serum and glucocorticoid kinase (SGK) family of serine/threonine kinases consists of three isoforms, SGK1, SGK2 and SGK3. This family of kinases is highly homologous to the AKT kinase family, sharing similar upstream activators and downstream targets. SGKs have been implicated in the regulation of cell growth, proliferation, survival and migration: cellular processes that are dysregulated in cancer.