Immunoglobulin kappa locus at 2p11.2
immunoglobulin kappa locus at 2p11.2
The human IGK locus is at 2p11.2 and contains IGKV (variable) genes, IGKJ (joining) genes and one IGKC (constant) gene. Most individuals have two clusters of the IGKV genes resulting from a duplication. The clusters are designated as either proximal or distal to the IGKC gene. Genes from the distal cluster are denoted with a 'D' in the symbol while those without a 'D' are located in the proximal cluster.