DMPK kinase family
dmpk kinase family
The DMPK kinases are members of the AGC kinase family with a conserved domain architecture of N-terminal kinase domains followed by a predicted coiled-coil domain and C-terminal regulatory domains that mediate a variety of protein-protein and protein-membrane interactions. While many AGC kinases are regulated by phosphorylation of motifs in their activation loop or C-terminal tail, the DMPK kinases are not. Instead, their N-terminal capped-helix bundle (CHB) domain cooperates with the C-terminal tail to maintain the kinase domain in a homodimeric, active conformation with an ordered activation loop. Protein kinases of the DMPK family are critical regulators of actomyosin contractility in cells.