Helix-turn-helix CENPB type domain family
helix-turn-helix cenpb type domain family
The CENPB family is derived from the tcl/mariner/pogo family of DNA transposases. In the case of CENPB, the catalytic transposase domain — the 'DDE motif', so-called because of the three conserved amino acids that are vital for its exonuclease functionality — has been mutated such as to be theoretically nonfunctional. Other family members likewise lack the catalytic DDE motif.