TIM23 complex
tim23 complex
Tim17 and Tim23 form the core of the complex onto which all other subunits assemble.   Complete translocation into the matrix is mediated by the import motor of the TIM23 complex, also referred to as PAM (presequence translocase-associated motor). mtHsp70 (encoded by HSPA1A, HSPA1B and HSPA1L,) is the central component of the import motor. Its ATP-dependent action, regulated by the J and J-like proteins DNAJC19 (aliases: Tim14/Pam18) and Tim16/Pam16 and the nucleotide exchange factor GRPEL1 (yeast ortholog Mge1), drives translocation of proteins across the inner membrane.