MCU complex subunits
mcu complex subunits
The mitochondrial calcium uniporter channel exists as a channel composed of a total of 4 MCU subunits and up to 4 SMDT1 subunits. In some cases, the dominant-negative MCU paralog, MCUB, replaces MCU subunits within the complex. The channel is gated by dimers of MICU1/2 or, in some tissues, dimers of MICU1/3. The accessory subunit MCUR1 also binds to and regulates the channel. Two uniporter channels can dimerize, and the function of these dimers is regulated by interactions between the MICU2 subunit associated with each channel.