Zinc fingers CCCH-type
zinc fingers ccch-type
Zinc finger proteins are generally thought of as DNA-binding transcription factors. However, certain classes of zinc finger proteins, such as CCCH zinc finger proteins, often function as RNA-binding proteins and regulate RNA metabolism. CCCH zinc finger proteins are characterized by one or more CCCH zinc finger domains containing three cysteines and a histidine. Although the functions of most CCCH zinc finger proteins remain obscure, emerging evidence suggests that some CCCH zinc finger proteins are involved in a broad range of biological processes that are associated with immune responses, including cytokine production, immune cell activation, immune homeostasis and antiviral innate immunity, as well as in regulation of cell differentiation and cancer cell growth.