Choline kinase family
choline kinase family
Choline kinases catalyse the conversion of choline to phosphocholine, which is further converted to cytidine diphosphate-coline (CDP-choline) in the biosynthesis of phosphatidylcholine (PC). PC is a major constituent of the phospholipid bilayer which constitutes the eukaryotic cell membrane, and regulates cell signal transduction. Functional choline kinase exists as a dimer, and can form homodimers or heterodimers with differential dynamics dependent on the tissue type. CHKA homodimers display higher enzymatic activity than CHKB homodimers and CHKA/B heterodimers with tissues differing in their relative expression of the varying isoforms.