JmjC hydroxylases
jmjc hydroxylases
The protein products of these genes catalyze the oxidation of proteins (for TYW5 a tRNA) to stable hydroxylated products. JmjC hydroxylases in general appear to have more open binding sites than the KDMs and bind their target residues primarily through main and side chain hydrogen bonds, rather than the principally hydrophobic interactions used by KDMs.