Microtubule associated serine/threonine kinase family
microtubule associated serine/threonine kinase family
The MAST kinases are highly conserved across nearly all eukaryotic groups, from single-celled protists to complex plants and animals. MAST1-4 are atypical in the AGC family. These large kinases possess multiple functional domains outside the AGC kinase core including the N-terminal domain of unknown function (DUF1908) and C-terminal PDZ domain. MASTL is shorter than the others as it only contains the kinase domain.