Harbinger transposase derived genes
harbinger transposase derived genes
The human genome encodes two proteins with homology to proteins encoded by Harbinger elements: HARBI1, a domesticated transposase-derived protein, and NAIF1, which contains a trihelix motif similar to that described in the Harbinger Myb-like protein. Physical interaction, subcellular localization, and DNA-binding activities of HARBI1 and NAIF1 suggest strong functional homologies between the Harbinger3_DR system and their related, host-encoded counterparts.