Heme peroxidase family
heme peroxidase family
Heme-containing peroxidases have a highly conserved structure and evolved to catalyze the oxidation of various substrates in the presence of H2O2 to serve diverse functions. MPO, EPX, and LPO have antimicrobial activities and serve in the first line of host defense, whereas TPO has an essential role in the biosynthesis of thyroid hormones. PDXN is involved in protein cross-linking in the extracellular matrix (ECM). PXDNL shares a high level of identity with PXDN but has lost its enzymatic activity.