MuvB complex subunits
muvb complex subunits
MuvB complexes are key to regulating the cell-division cycle. The MuvB complex can form part of the transcriptional repressor complex DREAM, or part of the activator complexes MMB and FOXM1-MuvB.  When cells are not actively dividing, the DREAM complex represses G1/S and G2/M genes. The expression of mitotic genes in the G2/M stage of the cell cycle can be regulated by MuvB activator complexes which include either the oncogenic transcription factor B-MYB or FOXM1.