Rho associated coiled-coil containing protein kinase family
rho associated coiled-coil containing protein kinase family
Rho associated coiled-coil kinases (ROCKs) are effectors of Rho family of small GTPases. ROCKs have multiple functions that include regulation of cellular contraction and polarity, adhesion, motility, proliferation, apoptosis, differentiation, maturation and remodeling of the extracellular matrix (ECM). ROCKs have an N-terminal kinase domain, a coiled-coiled region, Rho-binding domain, a pleckstrin homology domain and a cysteine-rich domain at the C-terminal.