TLC domain containing
tlc domain containing
The TLC domain is also known as the TRAM/LAG1/CLN8 homology domain (IPR006634).  InterPro describes the domain and family members as follows:   TLC is a protein domain with at least 5 transmembrane alpha-helices. Lag1p and Lac1p [yeast proteins] are essential for acyl-CoA-dependent ceramide synthesis [PMID: 11694577], TRAM1 is a subunit of the translocon and the CLN8 gene is mutated in Northern epilepsy syndrome. Proteins containing this domain may possess multiple functions such as lipid trafficking, metabolism, or sensing. Trh homologues [e.g. the CERS class homeobox class family in humans] possess additional homeobox domains [PMID: 9872981].