SIN3 histone deacetylase complex subunits
sin3 histone deacetylase complex subunits
Mammalian genomes encode two homologs of SIN3 (SIN3A/B), which associate individually with HDAC1 and HDAC2, RBBP4 and RBBP7, SDS3, and the SIN3-associated proteins SAP18 and SAP30 to form the core SIN3 complex. Different studies have identified additional interaction partners including MeCP2 (methyl-CpG-binding protein), RBP1 (RB-binding protein), BRMS1 (breast cancer metastasis suppressor), ING1/2 (inhibitor of growth), SAP25, SAP130, and SAP180, as well as the histone demethylase RBP2/KDM5A (Hayakawa and Nakayama, 2011 and Kadamb et al., 2013).