HOPS complex
hops complex
The HOPS tethering complex regulates late-endosomal tethering and shares several subunits with the CORVET complex that regulates early endosomal tethering. The membrane-targeting module in HOPS binds RILP (Rab interacting lysosomal protein). VPS11 acts as a molecular switch that binds either the CORVET complex specific TGFBRAP1 or HOPS specific VPS39/RILP thereby allowing selective targeting of these tethering complexes to early- or late endosomes to time fusion events in the endo/lysosomal pathway.