Guided entry of tail-anchored proteins complex subunits
guided entry of tail-anchored proteins complex subunits
Get3/TRC40 function requires an ER receptor, which in yeast consists of the Get1/Get2 heterotetramer and in mammals of the WRB protein (now approved as GET1 in human), homologous to yeast Get1, in combination with CAML (calcium-modulating cyclophilin ligand), which is not homologous to Get2.