SAND domain containing
sand domain containing
The SAND domain is a conserved sequence motif found in a number of nuclear proteins, including the Sp100 family and NUDR (HGNC note - 'NUDR' is an alias and this gene has the approved symbol <a href='https://genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:14677'>DEAF1</a>). These are thought to play important roles in chromatin-dependent transcriptional regulation and are linked to many diseases. We have determined the three-dimensional (3D) structure of the SAND domain from Sp100b. The structure represents a novel alpha/beta fold, in which a conserved KDWK sequence motif is found within an alpha-helical, positively charged surface patch.