Retrotransposon derived ASPRV1
retrotransposon derived asprv1
ASPRV1 is one of the human genes that have been domesticated from retrotransposons during vertebrate evolution. The protein expressed from this gene was defined as a retrovirus Gag-like protein as — besides its enzymatic domain — it contains a domain that is homologous to that of the Gag structural domain of the canonical retroviral polyprotein. The evolutionary origin was demonstrated by the homology between its Gag-like and protease domains and those of the retrovirus/retrotransposon proteins.