U4/U6 small nuclear ribonucleoprotein particle
u4/u6 small nuclear ribonucleoprotein particle
In order for U6 snRNA to enter into functional spliceosomes, it must first interact with U4 snRNA through an extensive base-pair interaction in a di-snRNP. Of the five snRNAs, U6 is the most likely to play a direct role in catalysis since it associates with the 5′ splice site of the pre-mRNA in the active core of functional spliceosomes (PMID:20659011)