NF-kappa B complex subunits
nf-kappa b complex subunits
NF-kappaB ( nuclear factor kappa-light-chain-enhancer of activated B cells ) is a protein complex that controls transcription of DNA, cytokine production and cell survival. NF-kappaB is found in almost all animal cell types and is involved in cellular responses to stimuli such as stress, cytokines, free radicals, ultraviolet irradiation, oxidized LDL, and bacterial or viral antigens. NF-kappaB plays a key role in regulating the immune response to infection (kappa light chains are critical components of immunoglobulins). Incorrect regulation of NF-kappaB has been linked to cancer, inflammatory and autoimmune diseases, septic shock, viral infection, and improper immune development. NF-kappaB has also been implicated in processes of synaptic plasticity and memory.