Potassium two pore domain channel subfamily K
potassium two pore domain channel subfamily k
The two-pore-domain potassium channel a family of 15 members form what is known as 'leak channels' which possess Goldman-Hodgkin-Katz (open) rectification. These channels are regulated by several mechanisms including oxygen tension, pH, mechanical stretch, and G-proteins. Their name is derived from the fact that the alpha subunits consist of four transmembrane segments, each containing two pore loops. As such, they structurally correspond to two inward-rectifier alpha subunits and thus form dimers in the membrane.