Protocadherins
protocadherins
The protocadherin (PCDH) gene family encodes proteins with an ectodomain comprising six or seven cadherin repeats with high sequence conservation within the family and weaker homology to the cadherin repeats of members of the major cadherin family. Further, protocadherins have a single transmembrane domain and a distinct, protocadherin-specific, cytoplasmic domain. Protocadherins can be further subdivided into clustered and non-clustered protocadherins on the basis of particular genomic organizations.