Zinc fingers A20-type
zinc fingers a20-type
This gene group represents genes encoding proteins with the zinc finger domain found in TNFAIP3, also known as A20. TNFAIP3 is an inhibitor of cell death that inhibits NF-kappaB activation via the tumour necrosis factor receptor associated factor pathway. The zinc finger domains appear to mediate self-association in TNFAIP3. These fingers also mediate IL-1-induced NF-kappa B activation.