Phosphofructokinase family
phosphofructokinase family
Phosphofructokinase (PFK) catalyses the phosphorylation of fructose 6-phosphate (F6P) to fructose 1,6-bisphosphate (F1,6BP) and plays a central role in the glycolytic pathway. The human enzymes are encoded by 3 paralogous genes: PFKM, PFKL and PFKP. While the isoforms were named for the tissue that they are prevalent or originally found (muscle, liver and platelet respectively) they are not limited to these tissues. The functional enzyme is a tetramer and can be formed from one or more isoforms. The kinetic/regulatory properties vary with subunit composition.