Small proline rich proteins
small proline rich proteins
SPRR genes encode proteins that are strongly induced during differentiation of human epidermal keratinocytes in vitro and in vivo and are a class of cornified envelope precursor proteins. The structure of the central segments of the encoded proteins are built up from tandemly repeated units of either eight (SPRR1 and SPRR3) or nine (SPRR2) amino acids with the general consensus *K*PEP**.