(6R)-5,10-methenyltetrahydrofolate + NADPH => (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + NADP(+)
(6r)-5,10-methenyltetrahydrofolate + nadph => (6r)-5,10-methylene-5,6,7,8-tetrahydrofolate + nadp(+)