dolabradiene + reduced [NADPH--hemoprotein reductase] + O2 = 15,16-epoxydolabrene + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)
dolabradiene + reduced [nadph--hemoprotein reductase] + o2 = 15,16-epoxydolabrene + oxidized [nadph--hemoprotein reductase] + h2o + h(+)