(2R,3R,5S)-2-(S-pantetheinyl)-carbapenam-3-carboxylate + AH2 + 2 S-adenosyl-L-methionine = (2R,3R,5S,6R)-6-(methyl)-2-(S-pantetheinyl)-carbapenam-3-carboxylate + 5'-deoxyadenosine + L-methionine + A + S-adenosyl-L-homocysteine + 2 H(+)
(2r,3r,5s)-2-(s-pantetheinyl)-carbapenam-3-carboxylate + ah2 + 2 s-adenosyl-l-methionine = (2r,3r,5s,6r)-6-(methyl)-2-(s-pantetheinyl)-carbapenam-3-carboxylate + 5'-deoxyadenosine + l-methionine + a + s-adenosyl-l-homocysteine + 2 h(+)