5-hydroxy-4-(hydroxymethyl)-7-methoxy-6-methylphthalide + reduced [NADPH--hemoprotein reductase] + O2 = cyclopolic acid + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)
5-hydroxy-4-(hydroxymethyl)-7-methoxy-6-methylphthalide + reduced [nadph--hemoprotein reductase] + o2 = cyclopolic acid + oxidized [nadph--hemoprotein reductase] + h2o + h(+)