(2E,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + NADPH + H(+) => (9Z,12Z,15Z,18Z,21Z)-tetracosapentaenoyl-CoA + NADP(+)
(2e,9z,12z,15z,18z,21z)-tetracosahexaenoyl-coa + nadph + h(+) => (9z,12z,15z,18z,21z)-tetracosapentaenoyl-coa + nadp(+)