17beta-estradiol + reduced [NADPH--hemoprotein reductase] + O2 = 6beta-hydroxyestradiol-17beta + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)
17beta-estradiol + reduced [nadph--hemoprotein reductase] + o2 = 6beta-hydroxyestradiol-17beta + oxidized [nadph--hemoprotein reductase] + h2o + h(+)