2-hydroxy-17beta-estradiol + S-adenosyl-L-methionine => 2-methoxy-17beta-estradiol + S-adenosyl-L-homocysteine + H(+)
2-hydroxy-17beta-estradiol + s-adenosyl-l-methionine => 2-methoxy-17beta-estradiol + s-adenosyl-l-homocysteine + h(+)