a C29-steroid + reduced [NADPH--hemoprotein reductase] + O2 <=> a (22S)-22-hydroxy C29-steroid + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)
a c29-steroid + reduced [nadph--hemoprotein reductase] + o2 <=> a (22s)-22-hydroxy c29-steroid + oxidized [nadph--hemoprotein reductase] + h2o + h(+)