pyruvate dehydrogenase (acetyl-transferring) activity
pyruvate dehydrogenase (acetyl-transferring) activity
Catalysis of the reaction: N(6)-[(R)-lipoyl]-L-lysyl-[protein] + pyruvate + H+ = N(6)-[(R)-S(8)-acetyldihydrolipoyl]-L-lysyl-[protein] + CO2.