estrone + reduced [NADPH--hemoprotein reductase] + O2 = 6alpha-hydroxyestrone + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)
estrone + reduced [nadph--hemoprotein reductase] + o2 = 6alpha-hydroxyestrone + oxidized [nadph--hemoprotein reductase] + h2o + h(+)