a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + S-adenosyl-L-methionine = a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-ribonucleoside) in mRNA + S-adenosyl-L-homocysteine + H(+)
a 5'-end (n(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in mrna + s-adenosyl-l-methionine = a 5'-end (n(7)-methyl 5'-triphosphoguanosine)-(2'-o-methyl-ribonucleoside) in mrna + s-adenosyl-l-homocysteine + h(+)