(S)-scoulerine + S-adenosyl-L-methionine <=> (S)-tetrahydrocolumbamine + S-adenosyl-L-homocysteine + H(+)
(s)-scoulerine + s-adenosyl-l-methionine <=> (s)-tetrahydrocolumbamine + s-adenosyl-l-homocysteine + h(+)