(-)-4'-desmethyl-deoxypodophyllotoxin + reduced [NADPH--hemoprotein reductase] + O2 <=> 4'-demethylepipodophyllotoxin + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)
(-)-4'-desmethyl-deoxypodophyllotoxin + reduced [nadph--hemoprotein reductase] + o2 <=> 4'-demethylepipodophyllotoxin + oxidized [nadph--hemoprotein reductase] + h2o + h(+)