a ribonucleotide in RNA + S-adenosyl-L-methionine = a 2'-O-methylribonucleotide in RNA + S-adenosyl-L-homocysteine + H(+)
a ribonucleotide in rna + s-adenosyl-l-methionine = a 2'-o-methylribonucleotide in rna + s-adenosyl-l-homocysteine + h(+)