a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + ADP + H(+) => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ATP
a 1,2-diacyl-sn-glycero-3-phospho-(1d-myo-inositol-3,4,5-trisphosphate) + adp + h(+) => a 1,2-diacyl-sn-glycero-3-phospho-(1d-myo-inositol-4,5-bisphosphate) + atp