(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + CoA + H(+) => (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + H2O
(5z,8z,11z,14z,17z)-eicosapentaenoate + coa + h(+) => (5z,8z,11z,14z,17z)-eicosapentaenoyl-coa + h2o