phosphatidylinositol-4,5-bisphosphate phospholipase C activity
phosphatidylinositol-4,5-bisphosphate phospholipase c activity
Catalysis of the reaction: a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H+.