6-hydroxyprotopine + oxidized [NADPH--hemoprotein reductase] + H2O + H(+) => protopine + reduced [NADPH--hemoprotein reductase] + O2
6-hydroxyprotopine + oxidized [nadph--hemoprotein reductase] + h2o + h(+) => protopine + reduced [nadph--hemoprotein reductase] + o2
6-hydroxyprotopine + oxidized [NADPH--hemoprotein reductase] + H2O + H(+) => protopine + reduced [NADPH--hemoprotein reductase] + O2
6-hydroxyprotopine + oxidized [nadph--hemoprotein reductase] + h2o + h(+) => protopine + reduced [nadph--hemoprotein reductase] + o2