a (22S)-22-hydroxy C28-steroid + oxidized [NADPH--hemoprotein reductase] + H2O + H(+) => a C28-steroid + reduced [NADPH--hemoprotein reductase] + O2
a (22s)-22-hydroxy c28-steroid + oxidized [nadph--hemoprotein reductase] + h2o + h(+) => a c28-steroid + reduced [nadph--hemoprotein reductase] + o2
a (22S)-22-hydroxy C28-steroid + oxidized [NADPH--hemoprotein reductase] + H2O + H(+) => a C28-steroid + reduced [NADPH--hemoprotein reductase] + O2
a (22s)-22-hydroxy c28-steroid + oxidized [nadph--hemoprotein reductase] + h2o + h(+) => a c28-steroid + reduced [nadph--hemoprotein reductase] + o2