(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H2O <=> (6S)-5,6,7,8-tetrahydrofolate + formaldehyde
(6r)-5,10-methylene-5,6,7,8-tetrahydrofolate + h2o <=> (6s)-5,6,7,8-tetrahydrofolate + formaldehyde
(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H2O <=> (6S)-5,6,7,8-tetrahydrofolate + formaldehyde
(6r)-5,10-methylene-5,6,7,8-tetrahydrofolate + h2o <=> (6s)-5,6,7,8-tetrahydrofolate + formaldehyde