columbamine + S-adenosyl-L-methionine = palmatine + S-adenosyl-L-homocysteine + H(+)
columbamine + s-adenosyl-l-methionine = palmatine + s-adenosyl-l-homocysteine + h(+)
"columbamine O-methyltransferase"
"columbamine o-methyltransferase"