(R)-nicotine + A + H2O <=> (R)-6-hydroxynicotine + AH2
(r)-nicotine + a + h2o <=> (r)-6-hydroxynicotine + ah2
(R)-nicotine + A + H2O <=> (R)-6-hydroxynicotine + AH2
(r)-nicotine + a + h2o <=> (r)-6-hydroxynicotine + ah2