(S)-nicotine + A + H2O = (S)-6-hydroxynicotine + AH2
(s)-nicotine + a + h2o = (s)-6-hydroxynicotine + ah2
(S)-nicotine + A + H2O = (S)-6-hydroxynicotine + AH2
(s)-nicotine + a + h2o = (s)-6-hydroxynicotine + ah2