(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + NADPH + H(+) => (6S)-5-methyl-5,6,7,8-tetrahydrofolate + NADP(+)
(6r)-5,10-methylene-5,6,7,8-tetrahydrofolate + nadph + h(+) => (6s)-5-methyl-5,6,7,8-tetrahydrofolate + nadp(+)
(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + NADPH + H(+) => (6S)-5-methyl-5,6,7,8-tetrahydrofolate + NADP(+)
(6r)-5,10-methylene-5,6,7,8-tetrahydrofolate + nadph + h(+) => (6s)-5-methyl-5,6,7,8-tetrahydrofolate + nadp(+)