{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "UMLS:C1513741", "l": "Multilobated Lipoblast-Like Cell", "d": []}, {"i": "NCIT:C36971", "l": "Multilobated Lipoblast-Like Cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4322726", "l": "Mesothelial cell of arachnoid mater", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4085944", "l": "Allodepleted T Cell Immunotherapeutic ATIR101", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C3652635", "l": "technetium (99mTc) stannous agent labelled cells", "d": []}]}
{"type": "biolink:Cell", "ic": "85.457082654197222", "identifiers": [{"i": "CL:1001045", "l": "kidney cortex artery cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2953996", "l": "Endothelial cell of endocardium of left ventricle", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5446661", "l": "Autologous Anti-mesothelin TCR-expressing T-cells FH-TCR TMSLN", "d": []}, {"i": "NCIT:C175659", "l": "Autologous Anti-mesothelin TCR-expressing T-cells FH-TCR TMSLN", "d": ["A preparation of autologous T-lymphocytes that have been genetically engineered to express a T-cell receptor (TCR) specific for the tumor-associated antigen (TAA) human mesothelin (TMSLN), with potential immunomodulating and antineoplastic activities. Upon administration, the autologous anti-mesothelin TCR-expressing T-cells FH-TCR TMSLN specifically target and bind to mesothelin-expressing tumor cells. This leads to T-cell activation and T-cell mediated lysis of mesothelin-expressing tumor cells. Mesothelin, a cell surface glycoprotein involved in cell adhesion, is overexpressed in a variety of cancer cell types."]}]}
{"type": "biolink:Cell", "ic": "88.140761698499901", "identifiers": [{"i": "CL:0002362", "l": "cerebellar granule cell precursor", "d": ["A cell located in the outermost proliferative zone of the external germinal layer that can differentiate into astroglial cells and granule cells. This cell type is glial fibrillary acidic protein-positive and HNK1-positive."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4518177", "l": "Population of all cleft lymphocytes in portion of fluid", "d": []}, {"i": "SNOMEDCT:726766006", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C0022801", "l": "Hepatic macrophage", "d": []}, {"i": "NCIT:C12564", "l": "Kupffer Cell", "d": ["Large star-shaped or pyramidal cells with a large oval nucleus and a small prominent nucleolus. These intensely phagocytic cells line the walls of the sinusoids of the liver and form a part of the reticuloendothelial system."]}, {"i": "MESH:D007728", "l": "Kupffer Cells", "d": []}, {"i": "SNOMEDCT:256002", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:4033024", "l": "airway submucosal gland duct basal cell", "d": ["A basal cell that is part of a duct of an airway submucosal gland."]}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "CL:4023006", "l": "static nuclear bag fiber", "d": ["A nuclear bag fiber that is sensitive only changes in muscle length but not the rate of that change."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002265", "l": "type D cell of colon", "d": ["A D cell located in the colon."]}]}
{"type": "biolink:Cell", "ic": "92.728541327098611", "identifiers": [{"i": "CL:1000550", "l": "kidney papillary duct principal epithelial cell", "d": []}]}
{"type": "biolink:Cell", "ic": "86.236661114203869", "identifiers": [{"i": "CL:0002069", "l": "type II vestibular sensory cell", "d": ["Mostly cylindrical, resemble Type 1 in their contents and the presence of a kinocilium and stereocilium apically; much greater variation in size, some almost span the entire thickness of the sensory epithelium, while others are smaller than Type 1; receive multiple efferent nerve boutons around their bases as well as afferent endings, which are small expansions rather than chalices."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5401602", "l": "Virus Specific T-Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "CL:0002560", "l": "inner root sheath cell", "d": ["An epithelial cell that resides in the inner root sheath of the hair follicle."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0333794", "l": "Abnormal cellular component of blood", "d": []}, {"i": "SNOMEDCT:89615005", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1979666", "l": "Cells.CD19+CD58+", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C4289001", "l": "HPV-16 E7 TCR Expressing T-cells", "d": []}, {"i": "NCIT:C128485", "l": "HPV-16 E7 TCR Expressing T-cells", "d": ["A preparation of allogeneic, genetically engineered T-lymphocytes transduced with a retroviral vector MSGV1 that encodes a T-cell receptor (TCR) targeting a specific epitope of the human papillomavirus (HPV) type 16 oncoprotein E7 (HPV-16 E7 TCR), with potential antineoplastic activity. The TCR especially recognizes and binds with high affinity to the HPV 16 E7 11-19 epitope. Upon administration, HPV-16 E7 expressing T-cells target and bind to tumor cells expressing the HPV-16 E7 antigen leading to selective cytotoxicity in HLA-A2-positive, HPV-16 E7-expressing tumor cells. HPV16 E7, a tumor-associated antigen (TAA), overexpressed in a variety of tumor cell types while not expressed in normal, healthy cells, plays a key role in tumor cell proliferation. E7 11-19 is a naturally processed epitope of HPV-16 E7 that binds specifically to human leukocyte antigen (HLA)-A*02:01 and that has been isolated from the surface of HPV-16 positive, HLA-A*02:01-positive tumor cells."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5163441", "l": "Eosinophils | Nose | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "ic": "83.552982069901191", "identifiers": [{"i": "CL:0000794", "l": "CD8-positive, alpha-beta cytotoxic T cell", "d": ["A CD8-positive, alpha-beta T cell that is capable of killing target cells in an antigen specific manner with the phenotype perforin-positive and granzyme B-positive."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2951489", "l": "Type D enteroendocrine cell of gastric gland", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1183359", "l": "Type-3 epithelial cell of thymus", "d": []}]}
{"type": "biolink:Cell", "ic": "65.74027138291855", "identifiers": [{"i": "CL:0000624", "l": "CD4-positive, alpha-beta T cell", "d": ["A mature alpha-beta T cell that expresses an alpha-beta T cell receptor and the CD4 coreceptor."]}]}
{"type": "biolink:Cell", "ic": "68.769355763942954", "identifiers": [{"i": "UMLS:C1513961", "l": "Neoplastic Epithelial Polygonal Cell", "d": []}, {"i": "NCIT:C37036", "l": "Neoplastic Epithelial Polygonal Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C0037890", "l": "Spheroplasts", "d": []}, {"i": "NCIT:C12661", "l": "Spheroplast", "d": ["A cell that has lost it's typical shape and becomes spherical due to partial loss of the cell wall."]}, {"i": "MESH:D013104", "l": "Spheroplasts", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5707600", "l": "BCMA-targeted LCAR-BCDR Cells", "d": []}, {"i": "NCIT:C188123", "l": "BCMA-targeted LCAR-BCDR Cells", "d": ["A preparation of T-lymphocytes that have been genetically modified to express a chimeric antigen receptor (CAR) specific for the B-cell maturation antigen (BCMA; tumor necrosis factor receptor superfamily member 17; TNFRSF17), with potential immunostimulating and antineoplastic activities. Upon administration, BCMA-targeted LCAR-BCDR cells specifically recognize and kill BCMA-expressing tumor cells. BCMA, a tumor specific antigen and a receptor for both a proliferation-inducing ligand (APRIL) and B-cell activating factor (BAFF), is a member of the tumor necrosis factor (TNF) receptor superfamily and plays a key role in plasma cell survival; it is found on the surfaces of plasma cells and overexpressed on malignant plasma cells."]}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "CL:0005025", "l": "visceromotor neuron", "d": ["A motor neuron that synapses to parasympathetic neurons that innervate tear glands, sweat glands, and the smooth muscles and glands of the pulmonary, cardiovascular, and gastrointestinal systems."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0000720", "l": "anterior cone cell (sensu Endopterygota)", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1440400", "l": "Cells.t(11;19)(q23;p13.3)(MLL,MLLT1)", "d": []}]}
{"type": "biolink:Cell", "ic": "90.82444074280258", "identifiers": [{"i": "CL:0002619", "l": "adult endothelial progenitor cell", "d": ["An adult angioblastic cell released from the bone marrow, or from the kidney in some teleost species, capable of blood circulation and participation in angiogenesis by differentiating into blood vessel endothelial cells."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C0333853", "l": "Cleaved cell", "d": []}, {"i": "NCIT:C28128", "l": "Cleaved Cell", "d": []}, {"i": "SNOMEDCT:58604003", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0000687", "l": "R1 photoreceptor cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2335912", "l": "Fibroblast of papillary layer of dermis", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5421015", "l": "Rovaleucel", "d": []}, {"i": "NCIT:C174916", "l": "Rovaleucel", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C4764287", "l": "Autologous Cytotoxic T-lymphocytes Exposed to Dendritic Cells loaded with 6B11 Anti-idiotype Minibody", "d": []}, {"i": "NCIT:C158601", "l": "Autologous Cytotoxic T-lymphocytes Exposed to Dendritic Cells loaded with 6B11 Anti-idiotype Minibody", "d": ["A preparation of autologous cytotoxic T-lymphocytes (CTLs) that are exposed, ex vivo, to autologous dendritic cells (DCs) loaded with the anti-idiotype minibody 6B11, which mimics the epithelial ovarian tumor-associated antigen (TAA), OC166-9, with potential immunostimulatory and antineoplastic activities. Upon administration, the CTLs exposed to DCs loaded with 6B11 anti-idiotype minibody target and kill autologous ovarian cells expressing the TAA."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0000379", "l": "sensory processing neuron", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1515137", "l": "T-Immunoblast", "d": []}, {"i": "NCIT:C34034", "l": "T-Immunoblast", "d": ["A T-lymphocyte that has been transformed (activated) in response to antigenic stimulation. It will give rise to a population of T cells with specificity against the stimulating antigen."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C3176795", "l": "Blasts.cytoplasmic CD179a", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0000504", "l": "enterochromaffin-like cell", "d": ["A enteroendocrine cell part of the glands of the gastric mucosa. They produce histamine and peptides such as chromogranins. This cell type respond to gastrin by releasing histamine which acts as a paracrine stimulator of the release of hydrochloric acid from the gastric parietal cells."]}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "CL:0002595", "l": "smooth muscle cell of the subclavian artery", "d": ["A smooth muscle cell of the subclavian artery."]}]}
{"type": "biolink:Cell", "ic": "77.061101857006449", "identifiers": [{"i": "UMLS:C1514440", "l": "Primitive Striated Muscle Cell", "d": []}, {"i": "NCIT:C36949", "l": "Primitive Striated Muscle Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "46.917875266328451", "identifiers": [{"i": "UMLS:C1513973", "l": "Neoplastic Glandular Cell", "d": []}, {"i": "NCIT:C36763", "l": "Neoplastic Glandular Cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1267882", "l": "Lymphocyte negative for CD16 antigen and positive for CD57 antigen", "d": []}, {"i": "SNOMEDCT:117559008", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0333743", "l": "Corps ronds", "d": []}, {"i": "SNOMEDCT:40302004", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1514007", "l": "Neoplastic Large Pleomorphic Germ Cell", "d": []}, {"i": "NCIT:C36905", "l": "Neoplastic Large Pleomorphic Germ Cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5163447", "l": "Eosinophils | Synovial fluid | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "UMLS:C0014603", "l": "Epithelioid Cells", "d": []}, {"i": "NCIT:C12559", "l": "Epithelioid Cell", "d": ["A cell of mononuclear phagocyte system origin that resembles an epithelial cell and is involved in immune granuloma formation."]}, {"i": "MESH:D015622", "l": "Epithelioid Cells", "d": []}]}
{"type": "biolink:Cell", "ic": "67.198535815504115", "identifiers": [{"i": "CL:0000104", "l": "multipolar neuron", "d": ["A neuron with three or more neurites, usually an axon and multiple dendrites."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5163450", "l": "Eosinophils | Vitreous fluid | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "ic": "80.17194633000733", "identifiers": [{"i": "UMLS:C1709198", "l": "Neoplastic Sebocyte", "d": []}, {"i": "NCIT:C43338", "l": "Neoplastic Sebocyte", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0009068", "l": "CD8aa(I) thymocyte", "d": ["An unconventional T lymphocyte population within the thymic medulla that is potentially a thymic resident population."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5419238", "l": "Atleradstrocel", "d": []}, {"i": "NCIT:C171651", "l": "Atleradstrocel", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002457", "l": "epidermal Langerhans cell", "d": ["A Langerhans cell that is in the epidermis and is CD45-positive, MHCII-positive, and CD11b-positive."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5171668", "l": "Lymphocytes | Synovial fluid | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5761864", "l": "Allogeneic UCB-NK cells", "d": []}]}
{"type": "biolink:Cell", "ic": "87.120474278337809", "identifiers": [{"i": "CL:0002196", "l": "hepatic oval stem cell", "d": ["A transient hepatic stem cell observed after liver injury with a high nuclear to cytoplasm ratio that can differentiate into mature hepatocytes and bile duct cells. Arises from more than one tissue."]}]}
{"type": "biolink:Cell", "ic": "84.75972595860604", "identifiers": [{"i": "UMLS:C1512977", "l": "Mammalian Cell", "d": []}, {"i": "NCIT:C12958", "l": "Mammalian Cell", "d": ["A cell originating from or isolated from an animal of class Mammalia."]}]}
{"type": "biolink:Cell", "ic": "84.75972595860604", "identifiers": [{"i": "UMLS:C0333633", "l": "Hemosiderin-laden macrophage", "d": []}, {"i": "NCIT:C36847", "l": "Hemosiderin-Laden Macrophage", "d": []}, {"i": "SNOMEDCT:81236001", "d": []}]}
{"type": "biolink:Cell", "ic": "92.728541327098611", "identifiers": [{"i": "UMLS:C1710695", "l": "Xanthomatous Fibrohistiocytic Cell", "d": []}, {"i": "NCIT:C49081", "l": "Xanthomatous Fibrohistiocytic Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C4085976", "l": "Anti-MUC1 CAR-transduced Autologous T-lymphocytes", "d": []}, {"i": "NCIT:C124646", "l": "Anti-MUC1 CAR-transduced Autologous T-lymphocytes", "d": ["Autologous T-lymphocytes transduced with a retroviral vector expressing a chimeric antigen receptor (CAR) consisting of a single chain variable fragment (scFv) against the human tumor-associated epithelial antigen mucin 1 (MUC1), with potential immunomodulating and antineoplastic activities. Autologous PBLs from a patient with MUC1-positive cancer are transduced with a retroviral vector that encodes the CAR gene specific for MUC1. After expansion in culture and reintroduction into the patient, anti-MUC1 CAR-transduced autologous T-lymphocytes target and induce selective toxicity in MUC1-expressing tumor cells. MUC-1 is a human, hypoglycosylated tumor-associated antigen (TAA) overexpressed by epithelial cancer cells."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:1000314", "l": "gastric cardiac gland goblet cell", "d": ["A goblet cell that is part of the epithelium of gastric cardiac gland."]}]}
{"type": "biolink:Cell", "ic": "64.361282203588587", "identifiers": [{"i": "CL:0000746", "l": "cardiac muscle cell", "d": ["Cardiac muscle cells are striated muscle cells that are responsible for heart contraction. In mammals, the contractile fiber resembles those of skeletal muscle but are only one third as large in diameter, are richer in sarcoplasm, and contain centrally located instead of peripheral nuclei."]}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "CL:0009042", "l": "enteroendocrine cell of colon", "d": ["An enteroendocrine cell that is located in the colon."]}]}
{"type": "biolink:Cell", "ic": "92.728541327098611", "identifiers": [{"i": "CL:0001072", "l": "CD34-negative, CD117-positive innate lymphoid cell, human", "d": ["An innate lymphoid cell in the human with the phenotype CD34-negative, CD117-positive, and a precusor to NK cells, ILC2 cells, and ILC3 cells."]}]}
{"type": "biolink:Cell", "ic": "53.240006657058004", "identifiers": [{"i": "UMLS:C0032112", "l": "Plasma Cells", "d": []}, {"i": "NCIT:C12486", "l": "Plasma Cell", "d": ["A fully mature B-Cell that produces a specific antibody."]}, {"i": "MESH:D010950", "l": "Plasma Cells", "d": []}, {"i": "SNOMEDCT:113335003", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5401592", "l": "Allogenic Human Umbilical Derived Mesenchymal Stem Cells in Conditioned Media", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C4683875", "l": "Atypical Squamous Cell-Favor High-Grade Squamous Intraepithelial Lesion", "d": []}, {"i": "NCIT:C141519", "l": "Atypical Squamous Cell-Favor High-Grade Squamous Intraepithelial Lesion", "d": ["An abnormal squamous cell found in a cervical smear with cytologic features suggestive of high-grade squamous intraepithelial lesion."]}]}
{"type": "biolink:Cell", "ic": "92.728541327098611", "identifiers": [{"i": "CL:0000396", "l": "lamellocyte", "d": ["A hemocyte found in immuno-stimulated larvae."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:4030053", "l": "Island of Calleja granule cell", "d": ["A DRD1-expressing, medium spiny neuron-like granule cell that is part of an Island of Calleja."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0427534", "l": "Agranular white blood cell", "d": []}, {"i": "SNOMEDCT:250293008", "d": []}]}
{"type": "biolink:Cell", "ic": "77.061101857006449", "identifiers": [{"i": "UMLS:C1513934", "l": "Neoplastic Blastemal Cell", "d": []}, {"i": "NCIT:C37121", "l": "Neoplastic Blastemal Cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1267995", "l": "Lymphocyte positive for CD115 antigen", "d": []}, {"i": "SNOMEDCT:117435001", "d": []}]}
{"type": "biolink:Cell", "ic": "56.546041402708859", "identifiers": [{"i": "UMLS:C0039195", "l": "Cytotoxic T-Lymphocytes", "d": []}, {"i": "NCIT:C12543", "l": "Cytotoxic T-Lymphocyte", "d": ["Immunized T-lymphocytes which can directly destroy appropriate target cells. These cytotoxic lymphocytes may be generated in vitro in mixed lymphocyte cultures (MLC), in vivo during a graft-versus-host (GVH) reaction, or after immunization with an allograft, tumor cell or virally transformed or chemically modified target cell. These cells are distinct from natural killer cells and from killer cells mediating antibody-dependent cell cytotoxicity."]}, {"i": "MESH:D013602", "l": "T-Lymphocytes, Cytotoxic", "d": []}, {"i": "SNOMEDCT:420638008", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5163742", "l": "Erythrocytes.dysmorphic | Urine sediment | Urinalysis", "d": []}]}
{"type": "biolink:Cell", "ic": "90.82444074280258", "identifiers": [{"i": "UMLS:C1514016", "l": "Neoplastic Medium-Sized Myeloblast with Basophilic Agranular Cytoplasm", "d": []}, {"i": "NCIT:C37177", "l": "Neoplastic Medium-Sized Myeloblast with Basophilic Agranular Cytoplasm", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5163751", "l": "Erythrocytes.ghost cells | Blood | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5181336", "l": "Spermatozoa | Urine sediment | Urinalysis", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0229618", "l": "Large lymphocyte", "d": []}, {"i": "SNOMEDCT:54969003", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5383249", "l": "Leukocytes | Stem cell product | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0000497", "l": "red sensitive photoreceptor cell", "d": ["A photoreceptor cell that is sensitive to red light."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4484192", "l": "Neutrophil.fMLP stimulated.DHR", "d": []}]}
{"type": "biolink:Cell", "ic": "87.120474278337809", "identifiers": [{"i": "CL:0000648", "l": "kidney granular cell", "d": ["A smooth muscle cell that synthesizes, stores, and secretes the enzyme renin. This cell type are located in the wall of the afferent arteriole at the entrance to the glomerulus. While having a different origin than other kidney smooth muscle cells, this cell type expresses smooth muscle actin upon maturation."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0001042", "l": "T-helper 22 cell", "d": ["CD4-positive, alpha-beta T cell that produces IL-22."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4511163", "l": "Blast cell positive for cytoplasmic CD3 antigen", "d": []}, {"i": "SNOMEDCT:725483008", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1317188", "l": "Cells.CD13+CD33+", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5213149", "l": "Cells with cytogenetic abnormality | Blood or Tissue | Molecular pathology", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2736931", "l": "Cells.CD19+CD56+", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1513938", "l": "Neoplastic Chondroblast-Like Cell", "d": []}, {"i": "NCIT:C36986", "l": "Neoplastic Chondroblast-Like Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C4086007", "l": "Audencel", "d": []}, {"i": "NCIT:C123928", "l": "Audencel", "d": ["A therapeutic interleukin-12 (IL-12)-expressing dendritic cell (DC)-based vaccine composed of autologous monocyte-derived DCs loaded with autologous tumor cell lysate and exposed to the microbial cell wall component lipopolysaccharide (LPS), with potential immunomodulating and antineoplastic activities. The monocyte-derived immature DCs are loaded with autologous tumor cell lysates and are subsequently exposed to LPS and interferon-gamma (IFN-gamma). Upon administration of audencel, the mature DCs migrate into the lymph nodes, express the immune stimulatory cytokine interleukin-12 (IL-12) and activate the immune system by promoting the activation of natural killer (NK) cells and induce a cytotoxic T-lymphocyte (CTL)-mediated immune response against tumor cells, which may result in immune-mediated tumor cell death and inhibition of tumor cell proliferation. Exposure to LPS and IFN-gamma allows the maturation of DCs and optimizes the presentation of tumor-associated antigens (TAAs) by DCs to T-lymphocytes."]}]}
{"type": "biolink:Cell", "ic": "59.683039659913518", "identifiers": [{"i": "UMLS:C1711172", "l": "therapeutic autologous lymphocytes", "d": []}, {"i": "NCIT:C28681", "l": "Therapeutic Autologous Lymphocytes", "d": ["A population of lymphocytes isolated from an individual, altered in vitro, and returned to the same individual for therapeutic purposes. (NCI04)"]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:1000436", "l": "epithelial cell of lacrimal sac", "d": ["An epithelial cell that is part of the lacrimal sac."]}]}
{"type": "biolink:Cell", "ic": "87.120474278337809", "identifiers": [{"i": "UMLS:C1510965", "l": "Atypical Squamous Cells", "d": []}, {"i": "NCIT:C36913", "l": "Atypical Squamous Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0000647", "l": "multinucleated giant cell", "d": ["A phagocytic cell formed by the fusion of macrophages, occurs in chronic inflammatory responses to persistent microorganism such as M.tuberculosis, component of granulomas. Sometimes used to refer to megakaryocytes."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5237454", "l": "Allogeneic Anti-BCMA CAR-transduced T-cells ALLO-715", "d": []}, {"i": "NCIT:C165779", "l": "Allogeneic Anti-BCMA CAR-transduced T-cells ALLO-715", "d": ["A preparation of allogeneic, 'off-the-shelf' (OTS), universal transcription activator-like effector nuclease (TALEN)-engineered, gene-edited T-lymphocytes that have been transduced with a vector expressing a chimeric antigen receptor (CAR) containing a single chain variable fragment (scFv) derived from a monoclonal antibody specific for the human tumor-associated antigen (TAA) B-cell maturation antigen (BCMA; tumor necrosis factor receptor superfamily member 17; TNFRSF17), with potential immunostimulating and antineoplastic activities. Using TALEN technology, the T-cell receptor (TCR) alpha chain (TRAC) and CD52 genes are deleted from the CAR T-cells. Upon administration, the allogeneic anti-BCMA CAR-transduced T-cells ALLO-715 specifically recognize and induce selective toxicity in BCMA-expressing tumor cells. BCMA, a receptor for both a proliferation-inducing ligand (APRIL) and B-cell activating factor (BAFF), is a member of the tumor necrosis factor receptor superfamily (TNFRSF). BCMA is found on the surfaces of plasma cells, is overexpressed on malignant plasma cells and plays a key role in plasma cell proliferation and survival. Deletion of the CD52 gene makes the modified donor T-cells resistant to an anti-CD52 monoclonal antibody treatment, that is used during lymphodepletion. The knockout of TRAC eliminates TCR expression and is intended to abrogate the potential induction of graft-versus-host disease (GvHD) by the donor T-cells. The donor-derived, gene-edited CAR T cells have reduced production times and have increased availability when compared to autologous CAR-T cells, which use the patient's own cells and are produced on an individual basis. In addition, if the ALLO-715 cells cause unacceptable side effects, the incorporated CD20-based off-switch permits selective depletion of the ALLO-715 cells when the anti-CD20 monoclonal antibody rituximab is administered."]}]}
{"type": "biolink:Cell", "ic": "78.435418415656045", "identifiers": [{"i": "UMLS:C1518228", "l": "Malignant Oncocyte", "d": []}, {"i": "NCIT:C36942", "l": "Malignant Oncocyte", "d": ["A malignant epithelial cell with abundant eosinophilic or clear granular cytoplasm."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C3899739", "l": "CXCL12-Abundant Reticular Cell", "d": []}, {"i": "NCIT:C114786", "l": "CXCL12-Abundant Reticular Cell", "d": ["A fibroblast that expresses high levels of stromal cell-derived factor 1 (CXCL12), secretes type III collagen and forms processes that contact those of other similar cells to form a network of reticular fibers. These cells may play a role in hematopoietic stem cell maintenance."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002310", "l": "mammosomatotroph", "d": ["An acidophil cell of the anterior pituitary gland that produces both prolactin and growth hormone."]}]}
{"type": "biolink:Cell", "ic": "86.236661114203869", "identifiers": [{"i": "UMLS:C1881597", "l": "Malignant Spindle Transitional Cell", "d": []}, {"i": "NCIT:C60303", "l": "Malignant Spindle Transitional Cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5216221", "l": "Granulocytes|NCnc|Pt|Bld", "d": []}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "CL:1001609", "l": "muscle fibroblast", "d": ["Fibroblast from muscle organ."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5426720", "l": "Viable CD45 cells", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4696002", "l": "Cells.CD3+CD4+CD27+CD45RO+CD62L+", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C4553719", "l": "Autologous iC9-CARCD19 T Cells", "d": []}, {"i": "NCIT:C146823", "l": "Autologous iCASP9-CD19-expressing T-Lymphocytes", "d": ["A preparation of autologous T-lymphocytes that are transduced with a retroviral vector encoding a chimeric antigen receptor (CAR) specific for the tumor-associated antigen (TAA) CD19 and the inducible suicide gene human caspase 9 (iCASP9 or iC9), that is linked to a drug binding domain, with potential immunomodulating and antineoplastic activities. The iCASP9 construct consists of the entire coding sequence for the human FK506-drug binding protein (FKBP12) with an F36V mutation (FKBP12-F36V) that is linked to the gene encoding iC9, which is a modified form of the CASP9 gene where the sequences encoding the endogenous caspase activation and recruitment domains have been deleted. Upon intravenous administration, autologous iCASP9-CD19-expressing T-lymphocytes (iC9-CAR19 T-cells) target and bind to CD19-expressing tumor cells, thereby selectively lysing these tumor cells. If the administered T-cells cause unacceptable side effects, the chemical homodimerizer AP1903, which binds to the FKBP12-F36V drug-binding domain, can be administered; this induces caspase 9 expression, and results in apoptosis of the administered iC9-CAR19 T-cells. The CD19 antigen is a B-cell specific cell surface antigen expressed in all B-cell lineage malignancies."]}]}
{"type": "biolink:Cell", "ic": "90.82444074280258", "identifiers": [{"i": "CL:0002016", "l": "CD71-low, GlyA-positive polychromatic erythroblast", "d": ["A polychromatiic erythroblast that is Gly-A-positive and CD71-low."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5216247", "l": "Lymphocytes.variant|NCnc|Pt|Bld", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C3179110", "l": "Feeder Cells", "d": []}, {"i": "MESH:D061252", "l": "Feeder Cells", "d": []}]}
{"type": "biolink:Cell", "ic": "92.728541327098611", "identifiers": [{"i": "UMLS:C1881594", "l": "Malignant Small Germ Cell", "d": []}, {"i": "NCIT:C61386", "l": "Malignant Small Germ Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "48.188040833303326", "identifiers": [{"i": "CL:0000226", "l": "single nucleate cell", "d": ["A cell with a single nucleus."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157448", "l": "CD3+CD56+ cells | Blood | Cell markers", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157337", "l": "CD179a blasts | Bone marrow | Cell markers", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C0282560", "l": "Caco-2 Cells", "d": []}, {"i": "NCIT:C12912", "l": "Caco-2 Cell", "d": ["Human colonic adenocarcinoma cells that express features characteristic of mature intestinal cells, including enterocytes or mucus cells, which are used as in vitro models for studies investigating intestinal cell function and differentiation."]}, {"i": "MESH:D018938", "l": "Caco-2 Cells", "d": []}]}
{"type": "biolink:Cell", "ic": "92.728541327098611", "identifiers": [{"i": "CL:1001126", "l": "inner renal medulla vasa recta cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2331667", "l": "Type II of carotid body", "d": []}]}
{"type": "biolink:Cell", "ic": "86.236661114203869", "identifiers": [{"i": "CL:0002056", "l": "fraction F mature B cell", "d": ["A mature B cell subset originally defined as having being CD45R-positive, IgM-positive, IgD-positive and CD43-negative. Subsequent research demonstrated being CD21-positive and CD23-negative and CD93 negative."]}]}
{"type": "biolink:Cell", "ic": "80.511444690059548", "identifiers": [{"i": "CL:0000429", "l": "imaginal disc cell", "d": ["A columnar epithelial cell that is part of an insect imaginal disc."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0004124", "l": "retinal ganglion cell C1", "d": ["A retinal ganglion cell C inner that has medium dendritic diversity."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1179136", "l": "Type II taste bud cell", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5446544", "l": "Autologous Universal CAR-expressing T-lymphocytes UniCAR02-T", "d": []}, {"i": "NCIT:C175463", "l": "Autologous Universal CAR-expressing T-lymphocytes UniCAR02-T", "d": ["A preparation of autologous T-lymphocytes that has been genetically engineered to express a fully humanized, universal, second generation chimeric antigen receptor (CAR) with a CD28/CD3zeta co-stimulatory domain, and a binding domain that can recognize a peptide motive of an antigen-specific targeting module (TM), with potential immunomodulating and antineoplastic activities. Upon administration, autologous universal CAR-expressing T-lymphocytes UniCAR02-T remain inactivated. Upon administration of an antigen-specific TM, the binding domain of UniCAR02-T binds to the nuclear antigen motif of the TM, and UniCAR02-T is activated when the antigen-binding moiety of the TM binds to the specific antigen expressed on tumor cells. This induces selective toxicity in and causes lysis of tumor cells expressing the specific antigen."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5427578", "l": "Rods.left", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157528", "l": "CD3-CD57+ cells | Bone marrow | Cell markers", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C0227650", "l": "Juxtaglomerular cell", "d": []}, {"i": "NCIT:C13161", "l": "Juxtaglomerular Cell", "d": ["Any of a group of cells that are situated in the wall of each afferent arteriole of a kidney glomerulus near its point of entry adjacent to a macula densa and that produce and secrete renin."]}, {"i": "SNOMEDCT:56196004", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5549346", "l": "Cells.FOXP3 Ag", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1517639", "l": "KA09", "d": []}, {"i": "NCIT:C20269", "l": "KA09", "d": ["Provider: Karolinska Institute, Stockholm, Sweden. No information from provider. This cell line meets the criteria for the use of human embryonic stem cells by federally funded researchers."]}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "CL:0002590", "l": "smooth muscle cell of the brain vasculature", "d": ["A vascular associated smooth muscle cell of the brain vasculature."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:1000444", "l": "mesothelial cell of anterior chamber of eye", "d": ["A mesothelial cell that is part of the anterior chamber of eyeball."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:1000468", "l": "myoepithelial cell of acinus of lactiferous gland", "d": ["A myoepithelial cell that is part of the acinus of lactiferous gland."]}]}
{"type": "biolink:Cell", "ic": "86.236661114203869", "identifiers": [{"i": "UMLS:C5706883", "l": "SF1-Lineage Adenohypophysial Cell", "d": []}, {"i": "NCIT:C187078", "l": "SF1-Lineage Adenohypophysial Cell", "d": ["An adenohypophysial cell determined by the expression of the transcription factor SF1."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C0205832", "l": "Merkel Cells", "d": []}, {"i": "NCIT:C12592", "l": "Merkel Cell", "d": ["An epidermal cell, primarily located in the basal layer, that is thought to function in tactile sensory perception."]}, {"i": "MESH:D018862", "l": "Merkel Cells", "d": []}, {"i": "SNOMEDCT:10149001", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5421408", "l": "Allogeneic Red Cells Expressing 4-1BBL and IL-15TP", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5417809", "l": "Autologous Anti-BCMA-CAR-4-1BB-CD3zeta-expressing T-cells C-CAR088", "d": []}, {"i": "NCIT:C170747", "l": "Autologous Anti-BCMA-CAR-4-1BB-CD3zeta-expressing T-cells C-CAR088", "d": ["A preparation of autologous T-lymphocytes that have been transduced with a vector expressing a chimeric antigen receptor (CAR) containing a single chain variable fragment (scFv) specific for the epitome cluster E3 in the extracellular domain (ECD) of the tumor-associated antigen (TAA) B-cell maturation antigen (BCMA; tumor necrosis factor receptor superfamily member 17; TNFRSF17) that is fused to the co-stimulatory domain of 4-1BB (CD137) and the T-cell receptor signaling domain of CD3zeta (CD3z), with potential immunostimulating and antineoplastic activities. Upon administration, the autologous anti-BCMA-CAR-4-1BB-CD3zeta-expressing T-cells C-CAR088 specifically recognize and induce selective toxicity in BCMA-expressing tumor cells. BCMA, a tumor-specific antigen and a receptor for both a proliferation-inducing ligand (APRIL) and B-cell activating factor (BAFF), is a member of the tumor necrosis factor receptor superfamily (TNFRSF) and plays a key role in the survival of B-lymphocytes and plasma cells. BCMA is found on the surfaces of B-cells and is overexpressed on malignant plasma cells."]}]}
{"type": "biolink:Cell", "ic": "79.541110464886842", "identifiers": [{"i": "UMLS:C1709189", "l": "Neoplastic Parathyroid Gland Cell", "d": []}, {"i": "NCIT:C48265", "l": "Neoplastic Parathyroid Gland Cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4241121", "l": "Rhombencephalic neural crest cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157610", "l": "CD55 cells | Blood | Cell markers", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1699193", "l": "african green monkey kidney cells", "d": []}]}
{"type": "biolink:Cell", "ic": "84.75972595860604", "identifiers": [{"i": "CL:0002192", "l": "metamyelocyte", "d": ["A eosinophil precursor in the granulocytic series, being a cell intermediate in development between a myelocyte and a band form cell. The nucleus becomes indented where the indentation is smaller than half the distance to the farthest nuclear margin; chromatin becomes coarse and clumped; specific granules predominate while primary granules are rare."]}]}
{"type": "biolink:Cell", "ic": "81.648881485605159", "identifiers": [{"i": "UMLS:C1514020", "l": "Neoplastic Medium-Sized to Large T-Lymphocyte", "d": []}, {"i": "NCIT:C39614", "l": "Neoplastic Medium-Sized to Large T-Lymphocyte", "d": []}]}
{"type": "biolink:Cell", "ic": "75.58416670140862", "identifiers": [{"i": "CL:1000854", "l": "kidney blood vessel cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0231010", "l": "Penetrated oocyte", "d": []}, {"i": "SNOMEDCT:3447009", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5171667", "l": "Lymphocytes | Stool | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "ic": "90.82444074280258", "identifiers": [{"i": "UMLS:C1513926", "l": "Neoplastic Astrocyte with Few Flaccid Processes", "d": []}, {"i": "NCIT:C37135", "l": "Neoplastic Astrocyte with Few Flaccid Processes", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C4290030", "l": "4SCAR-GD2-modified T-lymphocytes", "d": []}, {"i": "NCIT:C128896", "l": "4SCAR-GD2-modified T-lymphocytes", "d": ["Genetically modified autologous T-lymphocytes transduced with a lentiviral vector encoding a fourth generation specific chimeric antigen receptor (4SCAR) specific for the disialoganglioside GD2 and which includes the CD3zeta chain and the signaling domains of the co-stimulatory molecules CD28, CD137, and CD27 fused with the suicide gene inducible caspase 9 (iCasp9), with potential immunomodulating and antineoplastic activities. Upon intravenous administration of 4SCAR-GD2 T-cells, these cells target the GD2 antigen on tumor cells to induce selective toxicity against GD2-expressing tumor cells. The tumor-associated antigen (TAA) GD2 is overexpressed on the surface of neuroblastoma cells and by other neuroectoderm-derived neoplasms, while it is minimally expressed on normal cells. iCasp9 consists of a human FK506 drug-binding domain with an F36V mutation (FKBP12-F36V) linked to human caspase 9. If the administered T-cells lead to unacceptable side effects, the chemical homodimerizer AP1903 can be administered; this binds to the drug binding FKBP12-F36V domain and activates caspase 9, which results in the apoptosis of the administered T-cells and enhances safety of this agent. CD28, CD137 and CD27, T-cell surface-associated co-stimulatory molecules, are required for full T-cell activation."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2325047", "l": "Martinotti cell of cerebral cortex", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:1000282", "l": "smooth muscle fiber of ascending colon", "d": ["A smooth muscle cell that is part of the ascending colon."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0333832", "l": "Tart cell", "d": []}, {"i": "SNOMEDCT:26819005", "d": []}]}
{"type": "biolink:Cell", "ic": "77.271239091128209", "identifiers": [{"i": "UMLS:C1881539", "l": "Malignant Blastemal Cell", "d": []}, {"i": "NCIT:C61293", "l": "Malignant Blastemal Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "82.532694649739099", "identifiers": [{"i": "CL:0002400", "l": "fraction B/C precursor B cell", "d": ["A precursor B cell that is AA4-positive, IgM-negative, CD19-positive, CD43-positive and HSA-positive."]}]}
{"type": "biolink:Cell", "ic": "84.75972595860604", "identifiers": [{"i": "UMLS:C1708914", "l": "Malignant Spindle-Shaped to Round Cell", "d": []}, {"i": "NCIT:C51147", "l": "Malignant Spindle-Shaped to Round Cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0042542", "l": "Vero Cells", "d": []}, {"i": "MESH:D014709", "l": "Vero Cells", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:1000375", "l": "myocardial endocrine cell of septal division of left branch of atrioventricular bundle", "d": ["A myocardial endocrine cell that is part of the septal division of left branch of atrioventricular bundle."]}]}
{"type": "biolink:Cell", "ic": "84.75972595860604", "identifiers": [{"i": "CL:0000446", "l": "chief cell of parathyroid gland", "d": ["An epithelial cell of the parathyroid gland that is arranged in wide, irregular interconnecting columns; responsible for the synthesis and secretion of parathyroid hormone."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2323492", "l": "Parasol ganglion cell of retina", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1710528", "l": "Umbilical Cord Blood Stem Cell", "d": []}, {"i": "NCIT:C43424", "l": "Umbilical Cord Blood Stem Cell", "d": ["A stem cell obtained from the umbilical cord."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4733591", "l": "autologous anti-CD20 CAR-T cells", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0009064", "l": "lymph node paracortex T cell", "d": ["A T cell located in the lymph node paracortex, where macrophages and dendritic cells present antigenic peptides to these naïve T cells, stimulating them to become activated helper T cells or cytotoxic T lymphocytes."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:4040002", "l": "enteroglial cell", "d": ["Glial cell that provides support to the enteric nervous system. It is involved in enteric neurotransmission, in maintaining the integrity of the mucosal barrier of the gut and serves as a link between the nervous and immune systems of the gut. In enteric nerve strands, glial processes ensheath multiaxonal bundles which distinguishes enteric glia from all other peripheral glia. Ultrastructurally, the most conspicuous trait of an enteroglial cell is the presence of 10 nm filaments, which criss-cross the cell body, form axial bundles in the processes and appear to firmly anchor the cells to the ganglionic surfaces. Similar to astrocytes, their main constituent is glial fibrillary acidic protein (GFAP)."]}]}
{"type": "biolink:Cell", "ic": "76.857431420584163", "identifiers": [{"i": "CL:0002063", "l": "type II pneumocyte", "d": ["A type II pneumocyte is a pneumocyte that modulates the fluid surrounding the alveolar epithelium by secreting and recycling surfactants. This cell type also contributes to tissue repair and can differentiate after injury into a type I pneumocyte. Thicker than squamous alveolar cells, have a rounded apical surface that projects above the level of surrounding epithelium. The free surface is covered by short microvilli."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0427890", "l": "Urinary epithelial cell", "d": []}, {"i": "SNOMEDCT:250442001", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C3714800", "l": "SCID-Repopulating Cell", "d": []}, {"i": "NCIT:C114279", "l": "SCID-Repopulating Cell", "d": ["A human hematopoietic stem cell that is able to repopulate the hematopoietic system of non-obese diabetic/severe combined immunodeficient mice (NOD/SCID). Ex vivo culture conditions that can enrich these stem cells from peripheral blood samples could potentially be used to treat immunodeficiency in human patients."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002537", "l": "amnion mesenchymal stem cell", "d": ["A mesenchymal stem cell of the amnion membrane."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2327051", "l": "Epithelial cell of esophageal gland proper", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1954356", "l": "X linked heterotaxy", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "MESH:D033761", "l": "Spores, Protozoan", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0945916", "l": "Cells.CD11b", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C4725117", "l": "Anti-CD3/MUC1 Antibody-armed PD-1 Inhibitor-induced Cytokine-induced Killer Cells", "d": []}, {"i": "NCIT:C148543", "l": "Anti-CD3/MUC1 Antibody-armed PD-1 Inhibitor-induced Cytokine-induced Killer Cells", "d": ["A preparation of cytokine-induced killer cells (CIKs), which have been exposed, ex vivo, to a specific set of cytokines and a programmed cell death protein 1 (PD-1) inhibitor, mixed with a bispecific anti-cluster of differentiation 3 (CD3)/anti-mucin-1 (MUC1) antibody, with potential anti-tumor cytotoxic activity. Upon administration of the anti-CD3/MUC1 antibody-armed PD-1 inhibitor-induced CIKs, the antibody moiety binds to both CD3 on the CIKs and MUC1 on cancer cells. This crosslinks the CIKs and tumor cells, which allows the CIKs to target and lyse MUC1-expressing cancer cells. PD-1 blockade activates the CIKs. The cytokines used, usually interferon-gamma (IFNg), interleukin 1 (IL-1), and IL-2, stimulate the proliferation and maturation of peripheral blood mononuclear cells (PBMCs) into CIK cells. Anti-CD3 stimulation allows for the CIKs' improved lytic activity."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1440327", "l": "Cells.CD5+CD2-", "d": []}]}
{"type": "biolink:Cell", "ic": "45.110240697130934", "identifiers": [{"i": "CL:0002242", "l": "nucleate cell", "d": ["A cell containing at least one nucleus."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0009041", "l": "tuft cell of colon", "d": ["A tuft cell that is a part of the colon."]}]}
{"type": "biolink:Cell", "ic": "41.905447277272991", "identifiers": [{"i": "UMLS:C1510721", "l": "Abnormal Epithelial Cell", "d": []}, {"i": "NCIT:C36745", "l": "Abnormal Epithelial Cell", "d": ["An epithelial cell that occurs in human disease or in models of human disease."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5172510", "l": "Mesothelial cells | XXX | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5170942", "l": "Leukocytes | Urethra | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1268008", "l": "Eosinophilic granulocytic cell", "d": []}, {"i": "SNOMEDCT:127916009", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C4053969", "l": "Suppressive Monocyte", "d": []}, {"i": "NCIT:C122732", "l": "Suppressive Monocyte", "d": ["A population of monocytes that express CD14 and low or non-detectable levels of HLA-DR. The cells are able to suppress cellular immunity by inhibiting both T-cell proliferation and dendritic cell maturation."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4034569", "l": "Erythrocytes.ghost cells", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5163544", "l": "Epithelial cells | Vaginal | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157321", "l": "CD158 cells | Blood | Cell markers", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157328", "l": "CD16+CD56+CD3- | White blood cells | Cell markers", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1511185", "l": "Bizarre Neoplastic Stromal Giant Cell", "d": []}, {"i": "NCIT:C36826", "l": "Bizarre Neoplastic Stromal Giant Cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1183897", "l": "Epithelial cell of prostatic acinus", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C3891065", "l": "Mucosal-Associated Invariant T-Cell", "d": []}, {"i": "NCIT:C115217", "l": "Mucosal-Associated Invariant T-Cell", "d": ["A T-cell subtype bearing a semi-invariant T-cell receptor and restricted by the major histocompatibility complex related molecule MR1. These cells occupy peripheral tissues and are noted for their reactivity against various microorganisms of either bacterial or fungal origin."]}, {"i": "MESH:D000072336", "l": "Mucosal-Associated Invariant T Cells", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0225667", "l": "Dense-core granulated cell", "d": []}, {"i": "SNOMEDCT:85615000", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1267999", "l": "Lymphocyte positive for CD120B antigen", "d": []}, {"i": "SNOMEDCT:117439007", "d": []}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "UMLS:C0206428", "l": "Retinal Cone", "d": []}, {"i": "NCIT:C12637", "l": "Retinal Cone", "d": ["A photoreceptor cell located in the retina of the eye that allows high spatial acuity and color sensitivity."]}, {"i": "MESH:D017949", "l": "Retinal Cone Photoreceptor Cells", "d": []}, {"i": "SNOMEDCT:67540009", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157558", "l": "CD4+HLA-DR+ cells | Blood | Cell markers", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0043291", "l": "X-Chromosome-Bearing Sperm", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1512035", "l": "Dopaminergic Neurons", "d": []}, {"i": "NCIT:C26454", "l": "Dopaminergic Cell", "d": ["A nerve cell that employs dopamine as its neurotransmitter."]}, {"i": "MESH:D059290", "l": "Dopaminergic Neurons", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:1000419", "l": "myoepithelial cell of lactiferous duct", "d": ["A myoepithelial cell that is part of the lactiferous duct."]}]}
{"type": "biolink:Cell", "ic": "90.82444074280258", "identifiers": [{"i": "CL:1000143", "l": "lung goblet cell", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C4524459", "l": "Autologous EGFRt/19-28z/4-1BBL CAR T-Lymphocytes", "d": []}, {"i": "NCIT:C133189", "l": "Autologous EGFRt/19-28z/4-1BBL CAR T-Lymphocytes", "d": ["Genetically modified autologous T-lymphocytes transduced with a replication incompetent retroviral vector expressing both tumor necrosis factor ligand superfamily (TNFSF) member 9 (TNFSF9; 4-1BBL) and a chimeric T cell antigen receptor (CAR) consisting of an anti-CD19 scFv (single chain variable fragment), fused to the extracellular, transmembrane and intracellular signaling domains of the T-cell co-stimulatory receptor CD28, the cytoplasmic signaling domain of the zeta chain of the TCR/CD3 complex (CD3-zeta) (19-28z), and a truncated form of the human epidermal growth factor receptor (EGFRt), with potential immunostimulating and antineoplastic activities. Upon intravenous administration, autologous EGFRt/19-28z/4-1BBL CAR T-lymphocytes are directed to CD19-expressing tumor cells, which induces selective toxicity in CD19-expressing tumor cells. These cells also express 4-1BBL, a secreted protein and member of the TNFSF of growth factors, that induces proliferation of T-cells and may help reverse immunosuppression in the tumor environment. CD19 antigen is a B-cell specific cell surface antigen expressed in all B-cell lineage malignancies. The CD28 co-stimulatory molecule signaling domain enhances activation and signaling after recognition of CD19. The inclusion of the CD28 signaling domain may increase proliferation of T-cells and antitumor activity compared to the inclusion of the CD3-zeta chain alone. Devoid of both ligand binding domains and tyrosine kinase activity, EGFRt both facilitates in vivo detection of the administered, transduced T-cells and can promote elimination of those cells through a cetuximab-induced antibody dependent cellular cytotoxicity (ADCC) response."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5417953", "l": "Engineered Red Blood Cells Co-expressing 4-1BBL and IL-15TP RTX-240", "d": []}]}
{"type": "biolink:Cell", "ic": "66.9246167158351", "identifiers": [{"i": "CL:0000237", "l": "keratinizing barrier epithelial cell", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5556348", "l": "Autologous Anti-ILT3 CAR-T Cells", "d": []}, {"i": "NCIT:C180410", "l": "Autologous Anti-ILT3 CAR-T Cells", "d": ["A preparation of autologous T-lymphocytes that have been genetically modified to express a chimeric antigen receptor (CAR) specific for the immune inhibitory receptor leukocyte immunoglobulin-like receptor B member 4 (LILRB4; ILT3; ILT-3), with potential immune checkpoint inhibitory and antineoplastic activities. Upon administration, autologous anti-ILT3 CAR-T cells target and bind to ILT3-expressing tumor cells. This results in a cytotoxic T-lymphocyte (CTL) response against ILT3-expressing tumor cells. ILT3, a tumor associated antigen (TAA) and an immune inhibitory receptor expressed on immune suppressive myeloid cells, is highly expressed on certain hematologic cancer cells, such as monocytic acute myeloid leukemia (AML) cells. It functions as an immune checkpoint that negatively regulates T-cell activation as its extracellular domain inhibits T-cell activity. It plays an important role in tumor infiltration, T-cell suppression and immune tolerance."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C3496528", "l": "A5 noradrenaline cells", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C3496265", "l": "B2 serotonin cells", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157236", "l": "CD10 blasts | XXX | Cell markers", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1267987", "l": "Lymphocyte positive for CD100 antigen", "d": []}, {"i": "SNOMEDCT:117427004", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1440146", "l": "Blasts.CD33", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157467", "l": "CD3+HLA-DR+ cells | Bone marrow | Cell markers", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1513171", "l": "Metaplastic Columnar Cell", "d": []}, {"i": "NCIT:C37096", "l": "Metaplastic Columnar Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "85.457082654197222", "identifiers": [{"i": "UMLS:C1510729", "l": "Abnormal Large Granular Lymphocyte", "d": []}, {"i": "NCIT:C40983", "l": "Abnormal Large Granular Lymphocyte", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0545591", "l": "Blood, other cells", "d": []}]}
{"type": "biolink:Cell", "ic": "65.891564071043305", "identifiers": [{"i": "UMLS:C1514068", "l": "Neoplastic Polygonal Cell", "d": []}, {"i": "NCIT:C36851", "l": "Neoplastic Polygonal Cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2369073", "l": "MRC-5 cell line components", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:1000597", "l": "papillary tips cell", "d": ["A cell that is part of a tip of a renal papilla."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5706526", "l": "Autologous CAR T-Cells RD14-01", "d": []}, {"i": "NCIT:C189050", "d": []}]}
{"type": "biolink:Cell", "ic": "78.695011174409487", "identifiers": [{"i": "CL:0000178", "l": "Leydig cell", "d": ["A Leydig cell is a testosterone-secreting cell in the interstitial area, between the seminiferous tubules, in the testis."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002475", "l": "lymphoid MHC-II-negative non-classical monocyte", "d": ["A MHC-II-negative classical monocyte located in lymphoid tissue that is F4/80-positive, CD11c-intermediate, and CD11b-high."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1257771", "l": "Burst-Forming Units, Erythroid", "d": []}, {"i": "NCIT:C121480", "l": "Erythroid Burst Forming Unit", "d": ["A unit of viable cell concentration defined as the minimum number of hematopoietic stem cells able to produce a detectable colony of erythroid burst forming cells."]}, {"i": "SNOMEDCT:259732005", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2709115", "l": "Cells.CD138+Lambda+", "d": []}]}
{"type": "biolink:Cell", "ic": "87.120474278337809", "identifiers": [{"i": "CL:0002075", "l": "brush cell of trachebronchial tree", "d": ["Infrequent type of columnar epithelial cell. This cell is characterized by the presence of a tuft of blunt, squat microvilli (approximately 120-140/cell) on the cell surface. The microvilli contain filaments that stretch into the underlying cytoplasm. They have a distinctive pear shape with a wide base and a narrow microvillous apex. Function not known."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1979670", "l": "Cells.CD19+IgM+", "d": []}]}
{"type": "biolink:Cell", "ic": "77.488267285704651", "identifiers": [{"i": "UMLS:C1515963", "l": "Anaplastic Carcinoma Cell", "d": []}, {"i": "NCIT:C36848", "l": "Anaplastic Carcinoma Cell", "d": ["A malignant epithelial cell, usually of large size, characterized by the lack of differentiation. Anaplastic carcinoma cells have large hyperchromatic nuclei and display marked variation in nuclear size and shape, and high mitotic rate. Atypical mitotic figures are often present."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0597407", "l": "retinal bipolar neuron", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5154003", "l": "B lymphocytes | Bone marrow | Cell markers", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2339371", "l": "Regular ventricular cardiac myocyte", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5382751", "l": "CD11a cells | Blood | Cell markers", "d": []}]}
{"type": "biolink:Cell", "ic": "70.071335352100078", "identifiers": [{"i": "UMLS:C1708917", "l": "Malignant Spindle-Shaped Smooth Muscle Cell", "d": []}, {"i": "NCIT:C49126", "l": "Malignant Spindle-Shaped Smooth Muscle Cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1267893", "l": "Lymphocyte positive for both CD22 antigen and CD11C antigen", "d": []}, {"i": "SNOMEDCT:117566009", "d": []}]}
{"type": "biolink:Cell", "ic": "69.58597274768276", "identifiers": [{"i": "CL:0000598", "l": "pyramidal neuron", "d": ["Pyramidal neurons have a pyramid-shaped soma with a single axon, a large apical dendrite and multiple basal dendrites. The apex and an apical dendrite typically point toward the pial surface and other dendrites and an axon emerging from the base. The axons may have local collaterals but also project outside their region. Pyramidal neurons are found in the cerebral cortex, the hippocampus, and the amygdala."]}]}
{"type": "biolink:Cell", "ic": "77.271239091128209", "identifiers": [{"i": "UMLS:C1882059", "l": "Neoplastic Sex Cord-Stromal Cell Resembling Steroid Hormone-Secreting Cell", "d": []}, {"i": "NCIT:C61450", "l": "Neoplastic Sex Cord-Stromal Cell Resembling Steroid Hormone-Secreting Cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5690732", "l": "MDA-MB-231 Cells", "d": []}, {"i": "MESH:D000092302", "l": "MDA-MB-231 Cells", "d": []}]}
{"type": "biolink:Cell", "ic": "59.178645878518317", "identifiers": [{"i": "UMLS:C1514083", "l": "Neoplastic Sex Cord-Stromal Cell", "d": []}, {"i": "NCIT:C36898", "l": "Neoplastic Sex Cord-Stromal Cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1267808", "l": "SMIG+ lymphocyte", "d": []}, {"i": "SNOMEDCT:117512001", "d": []}]}
{"type": "biolink:Cell", "ic": "74.37742281270377", "identifiers": [{"i": "CL:0001019", "l": "CD115-positive monocyte OR common dendritic progenitor", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1512336", "l": "HeLa S3", "d": []}, {"i": "NCIT:C20227", "l": "HeLa S3", "d": ["HeLa S3 is a clonal derivative of the parent HeLa line. S3 was cloned in 1955 by T.T. Puck, P.I. Marcus, and S.J. Cieciura. This line can be adapted to grow in suspension."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C0376702", "l": "COS Cells", "d": []}, {"i": "NCIT:C17968", "l": "COS-1", "d": ["The line was derived from the CV-1 cell line (ATCC CCL-70) by transformation with an origin defective mutant of SV40 which codes for wild type T antigen. The cells contain a single integrated copy of the complete early region of the SV40 genome."]}, {"i": "MESH:D019556", "l": "COS Cells", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5670963", "l": "Umbilical Cord Blood-derived MAK Immune Cells", "d": []}, {"i": "NCIT:C187036", "l": "Umbilical Cord Blood-derived MAK Immune Cells", "d": ["A preparation of mixed-activated killer (MAK) immune cells derived from human umbilical cord blood (UCB) cells, with potential cytotoxic activity. Hematopoietic stem cells (HSCs) are isolated followed by ex vivo differentiation and expansion. Upon administration, the UCB-derived MAK immune cells may lyse cancer cells."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2697994", "l": "Allogeneic Multipotent Adult Progenitor Cells", "d": []}]}
{"type": "biolink:Cell", "ic": "61.078122804282714", "identifiers": [{"i": "UMLS:C1519262", "l": "Serous Adenocarcinoma Cell", "d": []}, {"i": "NCIT:C37115", "l": "Serous Adenocarcinoma Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002549", "l": "fibroblast of choroid plexus", "d": ["A fibroblast that is part of the choroid plexus."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5216199", "l": "Eosinophils.immature|NCnc|Pt|Bld", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1267974", "l": "Lymphocyte positive for CD83 antigen", "d": []}, {"i": "SNOMEDCT:117414003", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2964562", "l": "Viable CD34 cells", "d": []}]}
{"type": "biolink:Cell", "ic": "89.347505587204751", "identifiers": [{"i": "UMLS:C1511324", "l": "BresaGen ES Cell Line", "d": []}, {"i": "NCIT:C20247", "l": "BresaGen ES Cell Line", "d": []}]}
{"type": "biolink:Cell", "ic": "76.281523396999802", "identifiers": [{"i": "CL:2000064", "l": "ovarian surface epithelial cell", "d": ["Any epithelial cell that is part of a female gonad."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:4030056", "l": "umbrella cell of urothelium", "d": ["A urothelial cell that is terminally differentiated and part of the urothelial apical surface that forms the high-resistance barrier of urothelium. Umbrella cells have been described as the largest of urothelial cell types, highly polarized, and, in some species, multinucleated. In the relaxed state, these cells form a dome-shaped structure at the apical pole and can also cover multiple underlying intermediate cells, leading to the name umbrella cells. In contrast, these cells flatten when the bladder is filled."]}]}
{"type": "biolink:Cell", "ic": "87.120474278337809", "identifiers": [{"i": "CL:0002000", "l": "Kit-positive erythroid progenitor cell", "d": ["An erythroid progenitor cell is Kit-positive, Ly6A-negative, CD41-negative, CD127-negative, and CD123-negative. This cell type is also described as being lin-negative, Kit-positive, CD150-negative, CD41-negative, CD105-positive, and FcgR-negative."]}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "CL:0000431", "l": "iridophore", "d": ["A pigment cell derived from the neural crest. The cell contains flat light-reflecting platelets, probably of guanine, in stacks called reflecting platelets or iridisomes. The color-generating components produce a silver, gold, or iridescent color."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002473", "l": "MHC-II-high non-classical monocyte", "d": ["Gr1-low non-classical monocyte that has high surface expression of a MHC-II complex."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5214313", "l": "Villous lymphocytes | Blood | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2936410", "l": "Spongy Mesophyll Cells", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157526", "l": "CD3-CD57+ cells | Blood | Cell markers", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2340140", "l": "Type F enteroendocrine cell", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C4745325", "l": "ECT-001 Expanded Cord Blood", "d": []}, {"i": "NCIT:C156693", "l": "ECT-001 Expanded Cord Blood", "d": ["A preparation of umbilical cord blood (UCB) co-cultured and expanded in an optimized culture system with a small molecule agonist of hematopoietic stem cell (HSC) renewal, with potential use in hematopoietic cell transplantation (HCT). Upon administration, the ECT-001 expanded cord blood cells increase and restore the number of hematopoietic stem and progenitor cells (HSPCs) that can differentiate into a variety of cell types and promote blood cell recovery. Compared to untreated UBCs, ECT-001 expanded UCB cells may exhibit enhanced stem cell proliferation and engraftment."]}]}
{"type": "biolink:Cell", "ic": "81.648881485605159", "identifiers": [{"i": "CL:4023118", "l": "L5/6 non-Martinotti sst GABAergic interneuron (Mmus)", "d": ["A sst GABAergic interneuron does not have Martinotti morphology with a soma found in L5/6 of the cerebral cortex."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C4725079", "l": "Autologous PSMA-specific TGFb-resistant CAR T Cells", "d": []}, {"i": "NCIT:C148496", "l": "Autologous PSMA-specific TGFb-resistant CAR T Cells", "d": ["Autologous T-lymphocytes transduced with a lentiviral vector expressing a chimeric antigen receptor (CAR) consisting of an anti-prostate specific membrane antigen (PSMA) single chain variable fragment (scFv) and expressing a dominant negative (DN) form of transforming growth factor-beta (TGF-beta; TGFb) receptor, with potential immunomodulating and antineoplastic activities. Upon transfusion, the autologous PSMA-specific TGFb-resistant CAR T cells are directed to and induce selective toxicity in PSMA-expressing tumor cells. The tumor-associated antigen (TAA) PSMA is overexpressed by prostate cancers; its expression is associated with poor prognosis and metastasis. The inclusion of the DN TGFb receptor blocks signaling of the immunosuppressive cytokine TGFb in the tumor microenvironment (TME) and makes the CAR T cells resistant to TGFb. TGFb negatively regulates T-cell proliferation and activation and plays a key role in tumor immune suppression."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0228072", "l": "Large neuron", "d": []}, {"i": "SNOMEDCT:24031008", "d": []}]}
{"type": "biolink:Cell", "ic": "88.140761698499901", "identifiers": [{"i": "UMLS:C1455888", "l": "Atypical Glandular Cell", "d": []}, {"i": "NCIT:C36912", "l": "Atypical Glandular Cell", "d": ["An abnormal endocervical or endometrial cell found in a cervical smear, not further characterized as neoplastic or non-neoplastic. It is often associated with clinically significant uterine lesions."]}]}
{"type": "biolink:Cell", "ic": "69.133783595722377", "identifiers": [{"i": "CL:4023008", "l": "intratelencephalic-projecting glutamatergic cortical neuron", "d": ["A glutamatergic neuron located in the cerebral cortex that projects to structures of telencephalic origins."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157368", "l": "CD2 cells | Blood | Cell markers", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4722715", "l": "S68587", "d": []}]}
{"type": "biolink:Cell", "ic": "77.712653754434029", "identifiers": [{"i": "UMLS:C1708912", "l": "Malignant Spindle-Shaped Fibrohistiocytic Cell", "d": []}, {"i": "NCIT:C49072", "l": "Malignant Spindle-Shaped Fibrohistiocytic Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "82.532694649739099", "identifiers": [{"i": "CL:0004251", "l": "narrow field retinal amacrine cell", "d": ["An amicrine that has a narrow dendritic field."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2336898", "l": "Hemal stem cell", "d": []}]}
{"type": "biolink:Cell", "ic": "80.511444690059548", "identifiers": [{"i": "CL:0000914", "l": "immature NK T cell", "d": ["An immature alpha-beta T-cell that express Egr2. These cells give rise to T cells expressing NK markers."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5216306", "l": "Plasma cells|NCnc|Pt|Bld", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1440399", "l": "Cells.t(11;14)(q13;q32)(CCND1,IGH)", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4086010", "l": "betibeglogene autotemcel", "d": []}, {"i": "MESH:C000721148", "l": "betibeglogene autotemcel", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0000176", "l": "ecdysteroid secreting cell", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C4684956", "l": "Autologous Gamma-retroviral MSGV1 139 scFv EGFRvIII CAR Gene-modified T Cells", "d": []}, {"i": "NCIT:C143060", "l": "Autologous Gamma-retroviral MSGV1 139 scFv EGFRvIII CAR Gene-modified T Cells", "d": ["A preparation of autologous T-lymphocytes transduced with the gamma retroviral vector MSGV1 expressing a chimeric T-cell antigen receptor (CAR) consisting of a single-chain variable fragment (scFv) from a specific antibody clone (mAb139) that targets a mutant form of epidermal growth factor receptor (EGFR) known as variant III (EGFRvIII; EGFR-vIII), with potential antineoplastic activity. Upon intratumoral administration, the gamma-retroviral MSGV1 139 scFv EGFRvIII CAR gene-modified T-cells specifically target and bind to tumor cells expressing EGFRvIII, leading to selective cytotoxicity in EGFRvIII-expressing tumor cells. EGFRvIII, a tumor-associated antigen (TAA) encoded by an in-frame deletion of exons 2-7 in the EGFR gene, is specifically overexpressed by a subset of tumor cells and is not expressed in normal, healthy cells. It plays a key role in tumor cell proliferation, tumor angiogenesis and radio- and chemoresistance."]}]}
{"type": "biolink:Cell", "ic": "67.292420608345139", "identifiers": [{"i": "CL:0002009", "l": "macrophage dendritic cell progenitor", "d": ["A progenitor cell that can give rise to plasmacytoid and myeloid dendritic cells, and to monocytes and macrophages."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2331019", "l": "Set of cholinergic cells of dorsal tegmental area [Ch8]", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C3652665", "l": "chromium (51Cr) chromate labelled cells", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5216317", "l": "Promyelocytes|NCnc|Pt|Body fld", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5206702", "l": "Patient-derived WT1/PRAME/Survivin-specific Cytotoxic T-lymphocytes", "d": []}, {"i": "NCIT:C162624", "l": "Patient-derived WT1/PRAME/Survivin-specific Cytotoxic T-lymphocytes", "d": ["A preparation of autologous cytotoxic T-lymphocytes (CTLs) specifically reactive to the tumor associated antigens (TAAs) human Wilms tumor protein (WT1), preferentially expressed antigen of melanoma (PRAME, melanoma antigen preferentially expressed in tumors; Opa-interacting protein 4), and survivin (baculoviral IAP repeat-containing protein 5), with potential antineoplastic activities. Upon collection, expansion, and stimulation with antigen presenting cells pulsed with an overlapping peptide library spanning the TAAs, the multi-antigen associated CTLs are re-introduced into the patient and may induce a CTL-mediated response against tumor cells expressing WT1, PRAME, or survivin, potentially leading to tumor cell lysis and inhibition of tumor cell proliferation. WT1, PRAME, and survivin, are expressed on certain tumor cell types and play key role in tumor cell proliferation and survival."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0009043", "l": "intestinal crypt stem cell of colon", "d": ["An intestinal crypt stem cell that is located in the colon."]}]}
{"type": "biolink:Cell", "ic": "70.14367232259255", "identifiers": [{"i": "CL:0000954", "l": "small pre-B-II cell", "d": ["A small pre-B-II cell is a pre-B-II cell that is Rag1-positive, Rag2-positive, pre-BCR-negative, and BCR-negative, is not proliferating, and carries a DNA rearrangement of one or more immunoglobulin light chain genes."]}]}
{"type": "biolink:Cell", "ic": "46.889640942973557", "identifiers": [{"i": "UMLS:C1510724", "l": "Abnormal Glandular Cell", "d": []}, {"i": "NCIT:C36764", "l": "Abnormal Glandular Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "60.068408496463064", "identifiers": [{"i": "UMLS:C1510737", "l": "Abnormal Transitional Cell", "d": []}, {"i": "NCIT:C36767", "l": "Abnormal Transitional Cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5175607", "l": "Other cells | Pleural fluid | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0001646", "l": "Adrenergic Fibers", "d": []}, {"i": "MESH:D000320", "l": "Adrenergic Fibers", "d": []}, {"i": "SNOMEDCT:361060001", "d": []}]}
{"type": "biolink:Cell", "ic": "92.728541327098611", "identifiers": [{"i": "CL:0000757", "l": "type 5 cone bipolar cell (sensu Mus)", "d": ["An ON-bipolar neuron found in the retina and having connections with cone photoreceptors cells and neurons in the inner half of the inner plexiform layer. The axon terminal is restricted to sublamina 3 of the inner plexiform layer. It is narrowly stratified and branched. The dendritic tree has many delicate branches."]}]}
{"type": "biolink:Cell", "ic": "84.128890093485552", "identifiers": [{"i": "CL:0000118", "l": "basket cell", "d": ["Basket cells are inhibitory GABAergic interneurons of the brain. In general, dendrites of basket cells are free branching and contain smooth spines. Axons are highly branched. The branched axonal arborizations give rise to basket-like structures that surround the soma of the target cell. Basket cells form axo-somatic synapses, meaning their synapses target somas of other cells."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4510889", "l": "Blast cell positive for CD7 antigen", "d": []}, {"i": "SNOMEDCT:724315001", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5555580", "l": "CD19-targeted CAR T2 Cells", "d": []}, {"i": "NCIT:C179281", "l": "CD19-targeted CAR T2 Cells", "d": ["A preparation of T-lymphocytes that have been genetically modified to express a chimeric antigen receptor (CAR) targeting the tumor-associated antigen (TAA) CD19, with potential immunostimulating and antineoplastic activities. Upon administration, CD19-targeted CAR T2 cells target and bind to CD19-expressing tumor cells, thereby inducing selective toxicity in CD19-expressing tumor cells. CD19 antigen is a B-cell specific cell surface antigen expressed in all B-cell lineage malignancies."]}]}
{"type": "biolink:Cell", "ic": "90.82444074280258", "identifiers": [{"i": "CL:2000043", "l": "brain pericyte", "d": ["Any pericyte cell that is part of a brain."]}]}
{"type": "biolink:Cell", "ic": "83.023198044254755", "identifiers": [{"i": "UMLS:C1710151", "l": "Spindle B Melanoma Cell", "d": []}, {"i": "NCIT:C54159", "l": "Spindle B Melanoma Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1515997", "l": "Anti-gp100 TCR Retroviral Vector-Transduced Autologous TIL", "d": []}, {"i": "NCIT:C38135", "l": "Anti-gp100 TCR Retroviral Vector-Transduced Autologous TIL", "d": ["Human tumor infiltrating lymphocytes (TIL) isolated from a melanoma patient and were engineered to react with the melanoma antigen glycoprotein 100 (gp100). These TIL are transfected with a retroviral pGCsam vector encoding T-cell receptors specific for gp100, grown in culture, and then transferred back to the patient. These genetically modified TIL may recognize and halt the growth of gp100-expressing melanoma cells."]}]}
{"type": "biolink:Cell", "ic": "90.82444074280258", "identifiers": [{"i": "UMLS:C1510959", "l": "Atypical Melanocyte", "d": []}, {"i": "NCIT:C36867", "l": "Atypical Melanocyte", "d": []}]}
{"type": "biolink:Cell", "ic": "92.728541327098611", "identifiers": [{"i": "CL:0002213", "l": "white muscle cell", "d": ["A muscle cell with low content of myoglobin and other oxygen storing proteins. This muscle cell has a white appearance."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:1000434", "l": "epithelial cell of external acoustic meatus", "d": ["An epithelial cell that is part of the external acoustic meatus."]}]}
{"type": "biolink:Cell", "ic": "88.140761698499901", "identifiers": [{"i": "CL:0000852", "l": "neuromast supporting cell", "d": ["Neuromast support cell is a non-sensory cell of the neuromast that extend between the sensory hair cells from the basement membrane to the apical surface; neuromast support cells are surrounded by neuromast mantle cells."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2718310", "l": "Gametes", "d": []}, {"i": "SNOMEDCT:308838004", "d": []}, {"i": "SNOMEDCT:308839007", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5173500", "l": "Mononuclear cells | Synovial fluid | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1440417", "l": "Cells.t(9;22)(q34.1;q11)(ABL1,BCR)", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5175648", "l": "Ovalocytes | Blood | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0882808", "l": "Cell positive for CD19 antigen", "d": []}, {"i": "SNOMEDCT:116753004", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002219", "l": "anchoring trophoblast", "d": ["A trophoblast found at the junction of the placenta. This cell type makes a unique fibronectin-trophouteronectin junction that helps mediate attachment of the placenta to the uterus. This cell type is also found junction of the chorion layer of the external membranes and the decidua."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0003044", "l": "M11 retinal ganglion cell", "d": ["A bistratified ganglion cell with small, dense dendritic fields that terminate in S1 and S3."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1440297", "l": "Cells.CD33+HLA-DR+", "d": []}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "CL:0002301", "l": "type B synovial cell", "d": ["A resident stromal cell located in the synovial membrane and responsible for the production of immune-related cytokines and chemokines. This cell type secretes glycoproteins and hyaluronic acid, has abundant granular endoplasmic reticulum, but contains fewer vacuoles and vesicles."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5166081", "l": "Granulocytes | Cerebral spinal fluid | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5448015", "l": "Zedenoleucel", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C4726562", "l": "Anti-CD19/CD20/CD22/CD30 CAR-T Cells", "d": []}, {"i": "NCIT:C151935", "l": "Anti-CD19/CD20/CD22/CD30 CAR-T Cells", "d": ["A preparation of human T-lymphocytes engineered to express a chimeric antigen receptor (CAR) specific for the tumor-associated antigens (TAAs) cluster of differentiation 19 (CD19), CD20, CD22 and CD30, with potential immunostimulating and antineoplastic activities. Upon administration, the anti-CD19/CD20/CD22/CD30 CAR-T cells target and bind to CD19, CD20, CD22 and CD30 expressed on the surface of certain tumor cells. This induces selective toxicity in tumor cells expressing these TAAs. The TAAs are overexpressed in certain hematologic malignancies."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0229588", "l": "Entire parathyroid wasserhelle cell", "d": []}, {"i": "SNOMEDCT:88360009", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002206", "l": "brush cell of terminal bronchiole", "d": ["A brush cell of the epithelium in the terminal bronchiole."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C3474412", "l": "HUMAN CORD BLOOD HEMATOPOIETIC PROGENITOR CELL 500000000 in 30 mL INTRAVENOUS LIQUID", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5549475", "l": "Spermatozoa Agglutinated | Urine | Fertility testing", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4240449", "l": "Vascular smooth muscle cell of peripheral artery", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1441339", "l": "100 blasts", "d": []}]}
{"type": "biolink:Cell", "ic": "72.473322228407739", "identifiers": [{"i": "UMLS:C0011306", "l": "Dendritic Cells", "d": []}, {"i": "NCIT:C12583", "l": "Dendritic Cell", "d": ["Immunocompetent cells of the lymphoid and hemopoietic systems and skin. They function morphologically and phenotypically by presenting or processing antigens, thereby stimulating cellular immunity. They represent the most potent antigen-presenting cells and, therefore, play a critical role in the primary T cell immune response."]}, {"i": "MESH:D003713", "l": "Dendritic Cells", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2599203", "l": "Donated egg", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2339111", "l": "Type 1 vestibular sensory cell of epithelium of macula of utricle of membranous labyrinth", "d": []}]}
{"type": "biolink:Cell", "ic": "83.023198044254755", "identifiers": [{"i": "CL:0002047", "l": "fraction B precursor B cell", "d": ["A precursor B cell that is CD45RA-positive, CD43-positive, CD24-positive and BP-1-negative."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C4763774", "l": "Autologous Anti-CD19CAR-CD28tm/4-1BB/CD3zeta-HER2tG-expressing CD4+/CD8+ T-lymphocytes SCRI-huCAR19v1", "d": []}, {"i": "NCIT:C157655", "l": "Autologous Anti-CD19CAR-CD28tm/4-1BB/CD3zeta-HER2tG-expressing CD4+/CD8+ T-lymphocytes SCRI-huCAR19v1", "d": ["A preparation of autologous CD4- and CD8-positive T-lymphocytes that have been transduced with a third-generation self-inactivating (SIN) lentiviral vector (LV) expressing a human-derived immunoglobulin G4 (IgG4) hinge-optimized chimeric antigen receptor (CAR) consisting of a single chain variable fragment (scFv) specific for CD19 that is fused to a human CD28 transmembrane domain (CD28tm), the intracellular cytoplasmic domain of 4-1BB (CD137) and the zeta chain of the TCR/CD3 complex (CD3zeta), and linked to a truncated form of the human epidermal growth factor receptor 2 (HER2tG), with potential immunostimulating and antineoplastic activities. Upon administration, the autologous CD4+/CD8+ T-lymphocytes SCRI-huCAR19v1 specifically target and bind to CD19-expressing neoplastic B-cells. This results in a cytotoxic T-lymphocyte (CTL) response against CD19-expressing tumor cells and causes tumor cell lysis. CD19 is a B-cell-specific cell surface antigen that is overexpressed in B-cell lineage tumors. Incorporation of the costimulatory signaling domains of CD28 and 4-1BB increases human T-cell function, expansion, and survival. Devoid of both ligand binding domains and tyrosine kinase activity, the co-expressed HER2tG both facilitates in vivo detection of the administered, transduced T-cells and can promote elimination of those cells through a trastuzumab-induced antibody dependent cellular cytotoxicity (ADCC) response."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157311", "l": "CD14 Monocytes | Blood | Cell markers", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C4087054", "l": "Donor-derived WT1/PRAME/NY-ESO-1/Survivin-specific T-lymphocytes", "d": []}, {"i": "NCIT:C123817", "l": "Donor-derived WT1/PRAME/NY-ESO-1/Survivin-specific T-lymphocytes", "d": ["Allogeneic T-lymphocytes specifically reactive to the tumor-associated antigens (TAAs) human Wilms tumor protein-1 (WT1), Preferentially Expressed Antigen in Melanoma (PRAME), the cancer-testis antigen NY-ESO-1, and survivin, with potential antineoplastic activity. Donor derived T-cells are mixed, ex vivo, with protein fragments derived from the TAAs WT1, PRAME, NY-ESO-1, and survivin. Upon intravenous administration, the donor-derived WT1/PRAME/NY-ESO-1/Survivin-specific T-lymphocytes recognize and kill cancer cells expressing these TAAs. WT1, NY-ESO-1, PRAME, and survivin, are expressed on certain tumor cell types and play key role in tumor cell proliferation and survival."]}]}
{"type": "biolink:Cell", "ic": "45.623206569390369", "identifiers": [{"i": "CL:0000402", "l": "CNS interneuron", "d": ["An interneuron that has its cell body in a central nervous system."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1184877", "l": "External pillar cell of cochlea", "d": []}]}
{"type": "biolink:Cell", "ic": "82.532694649739099", "identifiers": [{"i": "CL:0000749", "l": "ON-bipolar cell", "d": ["A bipolar neuron found in the retina and having connections with photoreceptors cells and neurons in the inner half of the inner plexiform layer. These cells depolarize in response to light stimulation of their corresponding photoreceptors."]}]}
{"type": "biolink:Cell", "ic": "84.128890093485552", "identifiers": [{"i": "CL:0001022", "l": "CD115-positive monocyte", "d": ["CD115-positive monocyte is a monocyte that is CD115-positive and CD11b-positive."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5420827", "l": "MUC-1/WT1 Peptide-primed Autologous Dendritic Cells", "d": []}, {"i": "NCIT:C174519", "l": "MUC-1/WT1 Peptide-primed Autologous Dendritic Cells", "d": ["A cell-based cancer vaccine composed of autologous monocyte-derived dendritic cells (DCs) loaded with the human tumor-associated antigens (TAAs) mucin-1 (MUC1) and Wilms tumor protein 1 (WT1), with potential immunomodulating and antineoplastic activities. Upon vaccination, the MUC-1/WT1 peptide-primed autologous DCs expose the immune system to MUC1 and WT1 peptides and may stimulate the host immune system to mount a cytotoxic T-lymphocyte (CTL) response against MUC1 and WT1-expressing cancer cells, which could result in cancer cell lysis. MUC1 and WT1, are overexpressed in a variety of tumor types and play an important role in tumor cell proliferation."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5216242", "l": "Lymphoblasts|NCnc|Pt|Bld", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1292099", "l": "IgE B lymphocyte", "d": []}, {"i": "SNOMEDCT:115605003", "d": []}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "CL:0002255", "l": "stromal cell of endometrium", "d": ["A stromal cell of the endometrium that is fibroblastic in appearance. During decidualization this cell may differentiate into a decidual stromal cell."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2950709", "l": "Set of Golgi neurons", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:1000285", "l": "smooth muscle cell of sigmoid colon", "d": ["A smooth muscle cell that is part of the sigmoid colon."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0314592", "l": "Colony-forming unit of macrophagocytic lineage", "d": []}, {"i": "SNOMEDCT:445092004", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0682527", "l": "hybrid cell line", "d": []}]}
{"type": "biolink:Cell", "ic": "71.423552501508112", "identifiers": [{"i": "CL:0000412", "l": "polyploid cell", "d": ["A cell that contains more than two haploid sets of chromosomes."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1301169", "l": "Pyknocyte", "d": []}, {"i": "SNOMEDCT:397049008", "d": []}]}
{"type": "biolink:Cell", "ic": "85.457082654197222", "identifiers": [{"i": "UMLS:C1514072", "l": "Neoplastic Lactotroph Cell", "d": []}, {"i": "NCIT:C36918", "l": "Neoplastic Lactotroph Cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4510887", "l": "Blast cell positive for CD126 antigen", "d": []}, {"i": "SNOMEDCT:724305007", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0009088", "l": "circulating angiogenic cell", "d": ["An adult endothelial progenitor cell characterised in vivo by homing to ischemic sites and paracrine support of angiogenesis. These cells do not form colonies."]}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "UMLS:C1708882", "l": "Malignant Histiocyte-Like Cell", "d": []}, {"i": "NCIT:C49051", "l": "Malignant Histiocyte-Like Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:4023021", "l": "static gamma motor neuron", "d": ["A gamma motor neuron that innervates static nuclear bag fibers (bag2 fibers) and increases their firing, in response to an increase in the magnitude of change in length, and controls the static sensitivity of the stretch reflex."]}]}
{"type": "biolink:Cell", "ic": "79.246894609297499", "identifiers": [{"i": "UMLS:C1512477", "l": "Hodgkin-Like Cell", "d": []}, {"i": "NCIT:C37026", "l": "Hodgkin-Like Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5418086", "l": "Allogeneic Third-party Suicide Gene-transduced Anti-HLA-DPB1*0401 CD4+ T-cells CTL 19", "d": []}, {"i": "NCIT:C174401", "l": "Allogeneic Third-party Suicide Gene-transduced Anti-HLA-DPB1*0401 CD4+ T-cells CTL 19", "d": ["A preparation of allogeneic, third-party, CD4+ T-lymphocytes that specifically recognizes the human leukocyte antigen (HLA)-DPB1*0401 and transduced with a suicide gene, with potential antineoplastic activity. Upon administration, allogeneic third-party suicide gene-transduced anti-HLA-DPB1*0401 CD4+ T-cells CTL 19 specifically target and kill HLA-DPB1*0401-positive leukemic cells. The suicide gene causes the destruction of the T-cell clone upon the administration and presence of ganciclovir, which enhances the safety of the agent. HLA-DP is expressed by many leukemic cells."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C2348033", "l": "Cytomegalovirus pp65-Specific Cytotoxic T Lymphocytes", "d": []}, {"i": "NCIT:C71747", "l": "Cytomegalovirus pp65-Specific Cytotoxic T Lymphocytes", "d": ["Cytotoxic T lymphocytes (CTLs) specifically reactive to the cytomegalovirus (CMV) phosphoprotein pp65 with potential antiviral activity. To prepare CMV pp65-specific cytotoxic T lymphocytes in vitro, dendritic cells (DCs) are pulsed with CMV pp65 epitopes and then used to stimulate and propagate CMV pp65-specific cytotoxic T lymphocytes from peripheral blood mononuclear cells (PBMNCs); the CMV pp65-specific cytotoxic T lymphocyte population is then expanded so as to be sufficient for use in adoptive T lymphocyte therapy. When administered into a patient post-allogeneic hematopoietic stem cell transplantation, this agent may elicit a specific CTL response against CMV-infected host cells, which may result in the resolution of CMV infection. The CMV pp65 protein (65 kDa lower matrix phosphoprotein), the primary component of the enveloped subviral particle, is an immunodominant target for helper and cytotoxic T lymphocyte responses to CMV."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:1000482", "l": "myocardial endocrine cell of interventricular septum", "d": ["A myocardial endocrine cell that is part of the interventricular septum."]}]}
{"type": "biolink:Cell", "ic": "72.79108406015925", "identifiers": [{"i": "UMLS:C1513065", "l": "Neoplastic Medium-Sized B-Lymphocyte with Basophilic Cytoplasm", "d": []}, {"i": "NCIT:C37005", "l": "Neoplastic Medium-Sized B-Lymphocyte with Basophilic Cytoplasm", "d": []}]}
{"type": "biolink:Cell", "ic": "84.75972595860604", "identifiers": [{"i": "UMLS:C1881535", "l": "Malignant Apocrine Cell", "d": []}, {"i": "NCIT:C62500", "l": "Malignant Apocrine Cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5222945", "l": "CD3- CD16+ cells/100 cells in body fluid", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:1000437", "l": "epithelial cell of nasolacrimal duct", "d": ["An epithelial cell that is part of the nasolacrimal duct."]}]}
{"type": "biolink:Cell", "ic": "52.517241995836002", "identifiers": [{"i": "CL:0000365", "l": "animal zygote", "d": ["Diploid cell produced by the fusion of sperm cell nucleus and egg cell."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002512", "l": "CD11b-high, CD103-negative, langerin-negative lymph node dendritic cell", "d": ["A langerin-negative lymph node dendritic cell that is CD103-negative and CD11b-high."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:1000355", "l": "microfold cell of epithelium proper of small intestine", "d": ["A M cell that is part of the epithelium proper of small intestine."]}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "UMLS:C1522050", "l": "Granular Adenocarcinoma Cell", "d": []}, {"i": "NCIT:C36840", "l": "Granular Adenocarcinoma Cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1564017", "l": "Gastric delta Cells", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2337543", "l": "Paneth cell of epithelium of crypt of Lieberkuhn of small intestine", "d": []}]}
{"type": "biolink:Cell", "ic": "92.728541327098611", "identifiers": [{"i": "CL:0002002", "l": "Kit-positive granulocyte monocyte progenitor", "d": ["A granulocyte monocyte progenitor that is Kit-positive, CD34-positive, Fc-gamma receptor II/II-positive, and is Sca-1-negative, Il7ra-negative, Cxc3r1-negative, and CD90-negative."]}]}
{"type": "biolink:Cell", "ic": "89.347505587204751", "identifiers": [{"i": "CL:0000642", "l": "folliculostellate cell", "d": ["An agranular supporting cell of the anterior pituitary (adenohypophysis) that is characterized by a star-like morphology and ability to form follicles. Folliculostellate cells communicate with each other and with endocrine cells via gap junctions."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4518156", "l": "Population of all spermatozoa with abnormal head size in portion of fluid", "d": []}, {"i": "SNOMEDCT:725225001", "d": []}]}
{"type": "biolink:Cell", "ic": "88.140761698499901", "identifiers": [{"i": "CL:1001437", "l": "hair-down neuron", "d": ["The subcutaneous mechanoreceptors that innervate vellus hairs."]}]}
{"type": "biolink:Cell", "ic": "92.728541327098611", "identifiers": [{"i": "CL:0002158", "l": "external epithelial cell of tympanic membrane", "d": ["Epithelial cell found on the external side of the tympanic membrane"]}]}
{"type": "biolink:Cell", "ic": "41.000617082410265", "identifiers": [{"i": "UMLS:C1513942", "l": "Neoplastic Connective and Soft Tissue Cell", "d": []}, {"i": "NCIT:C36887", "l": "Neoplastic Connective and Soft Tissue Cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C3686472", "l": "Biliary epithelial cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5690734", "l": "Nasopharynx-Associated Lymphoid Tissue M Cells", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5175006", "l": "Normoblasts | Fetus | Blood | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157455", "l": "CD3+CD8+ (T8 suppressor) cells | Bone marrow | Cell markers", "d": []}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "CL:2000039", "l": "posterior lateral line neuromast supporting cell", "d": ["Any neuromast support cell that is part of a posterior lateral line."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0333728", "l": "Navicular cell", "d": []}, {"i": "SNOMEDCT:25006003", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C2698130", "l": "Anti-CEA IgCD28TCR-Transduced Autologous T Cells", "d": []}, {"i": "NCIT:C77865", "l": "Anti-CEA IgCD28TCR-Transduced Autologous T Cells", "d": ["A population of autologous tumor infiltrating lymphocytes (TIL) transduced with a retroviral vector encoding the chimeric gene IgCD28TCR with potential immunostimulating and antineoplastic activities. The chimeric IgCD28TCR gene consists of portions of CD28, the zeta chain of the T-cell receptor (TCRzeta), and a single chain antibody domain (sFv) specific for the tumor-associated antigen CEA.  Upon administration, these gene-modified TIL bind to tumor cells expressing CEA, which may result in activation and proliferation of TIL and an enhanced cytotoxic T-lymphocyte (CTL) response against CEA-expressing tumor cells. CEA may be overexpressed in various gastrointestinal and breast cancers. CD28, a T-cell surface-associated co-stimulatory molecule, is required for full T-cell activation, proliferation, and survival; expression of the CD28 fragment in this chimeric gene construct may impede activation-induced cell death (AICD) of TIL."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C4528182", "l": "Derived Synovial Fluid Cell", "d": []}, {"i": "NCIT:C138971", "l": "Derived Synovial Fluid Cell", "d": ["Cells derived from the fluid found in the cavities of synovial joints."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4518167", "l": "Population of all band basophils in portion of fluid", "d": []}, {"i": "SNOMEDCT:725232005", "d": []}]}
{"type": "biolink:Cell", "ic": "42.308366245531239", "identifiers": [{"i": "CL:2000029", "l": "central nervous system neuron", "d": ["Any neuron that is part of a central nervous system."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157308", "l": "CD14 blasts | Bone marrow | Cell markers", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5184819", "l": "Variant lymphocytes | Body fluid | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:4033051", "l": "OFF parasol ganglion cell", "d": ["A parasol ganglion cell that depolarizes in response to decreased light intensity in the center of its receptive field. The majority of input that this cell receives comes from DB3a bipolar cells."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5155095", "l": "Bite cells | Blood | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:4023081", "l": "inverted L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (Mmus)", "d": ["a L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex that has inverted pyramidal morphology."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4322671", "l": "CD14+ myeloid cell", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:1001572", "l": "colon endothelial cell", "d": ["A vascular endothelial cell found in colon blood vessels."]}]}
{"type": "biolink:Cell", "ic": "78.185623981295834", "identifiers": [{"i": "UMLS:C1514108", "l": "Neoplastic T-Lymphoblast", "d": []}, {"i": "NCIT:C37071", "l": "Neoplastic T-Lymphoblast", "d": []}]}
{"type": "biolink:Cell", "ic": "88.140761698499901", "identifiers": [{"i": "CL:0000214", "l": "synovial cell", "d": ["A cell located in the synovial joint."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4524846", "l": "Vadacabtagene leraleucel", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5401609", "l": "Stem-cell derived exosome vesicle products", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2323550", "l": "Primary motor neuron", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5706539", "l": "Membrane-bound IL-15-expressing Tumor-infiltrating Lymphocytes OBX-115", "d": []}]}
{"type": "biolink:Cell", "ic": "48.313152961937071", "identifiers": [{"i": "CL:0000527", "l": "efferent neuron", "d": ["A neuron which sends impulses peripherally to activate muscles or secretory cells."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5216210", "l": "Erythrocytes|NCnc|Pt|Bld", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1267943", "l": "Lymphocyte positive for CD51 antigen", "d": []}, {"i": "SNOMEDCT:117386007", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5163443", "l": "Eosinophils | Peritoneal fluid | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "ic": "92.728541327098611", "identifiers": [{"i": "CL:0002397", "l": "CD14-positive, CD16-positive monocyte", "d": ["A CD14-positive monocyte that is also CD16-positive and CCR2-negative."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5154483", "l": "Basophils | Synovial fluid | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4522887", "l": "Cells, Cultured, Autologous, Genetically-modified", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0000592", "l": "large luteal cell", "d": ["A large, progesterone secreting cell in the corpus luteum that develops from the granulosa cells."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1440360", "l": "Cells.CD82", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1515149", "l": "TE07", "d": []}, {"i": "NCIT:C20302", "l": "TE07", "d": ["Provider: Technion University, Haifa, Israel. No information from provider. This cell line meets the criteria for the use of human embryonic stem cells by federally funded researchers."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4733016", "l": "PP14 derivative-treated HLA-matched donor mononuclear cell-enriched leukocytes", "d": []}]}
{"type": "biolink:Cell", "ic": "83.023198044254755", "identifiers": [{"i": "CL:0001032", "l": "cortical granule cell", "d": ["Granule cell that is part of the cerebral cortex."]}]}
{"type": "biolink:Cell", "ic": "92.728541327098611", "identifiers": [{"i": "CL:1000306", "l": "fibroblast of tunica adventitia of artery", "d": ["A fibroblast that is part of the tunica adventitia of artery."]}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "CL:0000781", "l": "mononuclear odontoclast", "d": ["A specialized mononuclear osteoclast associated with the absorption and removal of cementum."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5158933", "l": "Cerebroventricular lining cells | Cerebral spinal fluid | Cytology", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157471", "l": "CD3+IL2R1+ cells | Blood | Cell markers", "d": []}]}
{"type": "biolink:Cell", "ic": "89.347505587204751", "identifiers": [{"i": "CL:1001588", "l": "colon glandular cell", "d": ["Glandular cell of colon epithelium. Example: Goblet cells; enterocytes or absorptive cells; enteroendocrine and M cells."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0545585", "l": "Blood small lymphocyte", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:2000006", "l": "tonsil germinal center B cell", "d": ["Any germinal center B cell that is part of a tonsil."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0000676", "l": "cap cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1267952", "l": "Lymphocyte positive for CD61 antigen", "d": []}, {"i": "SNOMEDCT:117393006", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1267969", "l": "Lymphocyte positive for CD77 antigen", "d": []}, {"i": "SNOMEDCT:117409002", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:4023088", "l": "large basket cell", "d": ["A basket cell that is large, and typically ascends to give rise to many long horizontally and vertically projecting axon collaterals that traverse neighboring columns and can extend through all cortical layers."]}]}
{"type": "biolink:Cell", "ic": "81.247621244257502", "identifiers": [{"i": "CL:0000463", "l": "epidermal cell (sensu Arthropoda)", "d": ["An epidermal cell that secretes chitinous cuticle from its apical side."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0019026", "l": "periportal region hepatocyte", "d": ["Any hepatocyte that is part of the liver lobule periportal region. These cells are primarily involved in oxidative energy metabolism."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0000761", "l": "type 9 cone bipolar cell (sensu Mus)", "d": ["An ON-bipolar neuron found in the retina and having connections with cone photoreceptors cells and neurons in the inner half of the inner plexiform layer. The dendritic tree is wide and the dendritic convergence indicates cone selectivity. The axon terminal is sparsely branched and terminates in sublamina 5 of the inner plexiform layer."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1564995", "l": "Retinal Bipolar Cells", "d": []}, {"i": "MESH:D051245", "l": "Retinal Bipolar Cells", "d": []}, {"i": "SNOMEDCT:72060002", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2328822", "l": "Type D cell of stomach", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1267916", "l": "Lymphocyte positive for CD39 antigen", "d": []}, {"i": "SNOMEDCT:117584006", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0000948", "l": "IgE memory B cell", "d": ["A class switched memory B cell that expresses IgE on the cell surface."]}]}
{"type": "biolink:Cell", "ic": "79.246894609297499", "identifiers": [{"i": "UMLS:C1883265", "l": "Tall Columnar Adenocarcinoma Cell", "d": []}, {"i": "NCIT:C60531", "l": "Tall Columnar Adenocarcinoma Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "85.457082654197222", "identifiers": [{"i": "CL:0000507", "l": "endorphin secreting cell", "d": ["A peptide hormone secreting cell that secretes endorphin."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157289", "l": "CD127 blasts | Blood | Cell markers", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1180254", "l": "Epithelial cell of gallbladder", "d": []}]}
{"type": "biolink:Cell", "ic": "82.532694649739099", "identifiers": [{"i": "CL:1001509", "l": "glycinergic neuron", "d": ["The neurons that utilize glycine as a neurotransmitter."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1444183", "l": "Cleidoic ovum", "d": []}]}
{"type": "biolink:Cell", "ic": "71.249364371823347", "identifiers": [{"i": "UMLS:C1708907", "l": "Malignant Small Round Cell", "d": []}, {"i": "NCIT:C53487", "l": "Malignant Small Round Cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5163556", "l": "Epithelial cells.squamous | Sputum | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0000356", "l": "hair matrix stem cell", "d": []}]}
{"type": "biolink:Cell", "ic": "55.756113031415936", "identifiers": [{"i": "UMLS:C1449624", "l": "Neuroepithelial Cells", "d": []}, {"i": "NCIT:C41410", "l": "Neuroepithelial Cell", "d": ["A neural stem cell that can give rise to radial glial progenitor cells which through subsequent divisions may generate neurons or mature glial cells. This may also refer to the specialized sensory epithelial cells of the olfactory, gustatory, and vestibulocochlear receptor systems."]}, {"i": "MESH:D046569", "l": "Neuroepithelial Cells", "d": []}]}
{"type": "biolink:Cell", "ic": "90.82444074280258", "identifiers": [{"i": "CL:0000482", "l": "juvenile hormone secreting cell", "d": ["An endocrine cell that secretes juvenile hormone."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0004120", "l": "retinal ganglion cell A1", "d": ["A retinal ganglion A cell found in the retina with large somata, often polygonal in shape. The dendritic fields consist of three to seven stout dendrites that are sparce near soma. Dendrites terminate in S4."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002449", "l": "CD94-positive Ly49CI-positive natural killer cell, mouse", "d": ["A NK1.1-positive T cell that is CD94-positive and Ly49Cl-positive."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2924433", "l": "Intestinal goblet cell", "d": []}]}
{"type": "biolink:Cell", "ic": "79.246894609297499", "identifiers": [{"i": "CL:0000072", "l": "non-branched duct epithelial cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4240451", "l": "Smooth muscle fiber of intestine", "d": []}]}
{"type": "biolink:Cell", "ic": "92.728541327098611", "identifiers": [{"i": "CL:0002335", "l": "brown preadipocyte", "d": ["A preadipocyte that is capable of differentiating into a brown adipocyte. This cell type expresses uncoupling protein-1, PPAR-gamma, PR-domain-containing 16; and PGC-1alpha (peroxisome proliferator-activated receptor-gamma (PPARgamma) coactivator-1alpha)."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5417911", "l": "Autologous Anti-CD19 T-cell Receptor Fusion Construct T-cells TC-110", "d": []}, {"i": "NCIT:C172366", "l": "Autologous Anti-CD19 T-cell Receptor Fusion Construct T-cells TC-110", "d": ["A preparation of autologous T-lymphocytes that have been genetically engineered to express a single-domain antibody that recognizes human CD19, fused to the CD3-epsilon T-cell receptor (TCR) subunit which, upon expression is incorporated into the endogenous TCR complex, with potential antineoplastic activity. Upon administration, the autologous anti-CD19 TCR fusion construct (TRuC) T-cells TC-110 specifically target and bind to CD19-expressing tumor cells. This leads to T-cell activation and T-cell mediated lysis of CD19-expressing tumor cells. CD19 antigen is a B-cell specific cell surface antigen overexpressed in B-cell lineage malignancies. Compared to chimeric antigen receptor (CAR) T-cells, TRuCs may be associated with less pro-inflammatory cytokine secretion and fewer adverse effects without compromising therapeutic efficacy."]}]}
{"type": "biolink:Cell", "ic": "84.128890093485552", "identifiers": [{"i": "CL:0000910", "l": "cytotoxic T cell", "d": ["A mature T cell that differentiated and acquired cytotoxic function with the phenotype perforin-positive and granzyme-B positive."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4510922", "l": "Blast cell positive for CD1a antigen", "d": []}, {"i": "SNOMEDCT:725176008", "d": []}]}
{"type": "biolink:Cell", "ic": "60.116197634896011", "identifiers": [{"i": "UMLS:C1514115", "l": "Neoplastic Transitional Cell", "d": []}, {"i": "NCIT:C36768", "l": "Neoplastic Transitional Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "73.239986017158159", "identifiers": [{"i": "UMLS:C1709185", "l": "Neoplastic Mature Adipocyte", "d": []}, {"i": "NCIT:C48897", "l": "Neoplastic Mature Adipocyte", "d": []}]}
{"type": "biolink:Cell", "ic": "92.728541327098611", "identifiers": [{"i": "UMLS:C1180326", "l": "Olfactory epithelial cell", "d": []}, {"i": "NCIT:C13150", "l": "Olfactory Epithelial Cell", "d": ["A cell found in the pseudostratified epithelium lining the olfactory region of the nasal cavity. The olfactory epithelium has three major cell types - olfactory receptor cells, basal cell and sustentacular cells."]}]}
{"type": "biolink:Cell", "ic": "92.728541327098611", "identifiers": [{"i": "CL:1000465", "l": "chromaffin cell of ovary", "d": ["A chromaffin cell that is part of the ovary."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5171676", "l": "Lymphocytes Plasmacytoid | Blood | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:1000374", "l": "transitional myocyte of posterior division of left branch of atrioventricular bundle", "d": ["A transitional myocyte that is part of the posterior division of left branch of atrioventricular bundle."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1182608", "l": "Epithelial cell of parathyroid gland", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157484", "l": "CD33 blasts | Bone marrow | Cell markers", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C0393073", "l": "autologous Epstein-Barr virus-specific cytotoxic T lymphocytes (cell)", "d": []}, {"i": "NCIT:C12920", "l": "EBV-Specific Cytotoxic T-Lymphocyte", "d": ["A white blood cell that is derived from a lymphocyte stem cell matured in the thymus and characterized by a CD8 marker on the surface and an antigen-specific Epstein Barr virus T cell receptor."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5154301", "l": "Band form neutrophils | Synovial fluid | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "ic": "80.511444690059548", "identifiers": [{"i": "CL:0002328", "l": "bronchial epithelial cell", "d": ["An epithelial cell of the bronchus."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5420765", "l": "BCMA CART Cells Secreting Mutant PD-1Fc Fusion Protein", "d": []}, {"i": "NCIT:C174413", "l": "BCMA CART Cells Secreting Mutant PD-1Fc Fusion Protein", "d": ["A preparation of T-lymphocytes that have been genetically modified to express a chimeric antigen receptor (CAR) targeting the tumor-associated antigen (TAA) B-cell maturation antigen (BCMA; TNFRSF17) and secrete a fusion protein composed of programmed death 1 (PD-1; PDCD1; CD279; programmed cell death-1) and a human immunoglobulin Fc region, with potential immunomodulating and antineoplastic activities. Upon administration of the BCMA CART cells secreting mutant PD-1Fc fusion protein, these T-cells target and bind to tumor cells expressing BCMA and induce selective cytotoxicity in those tumor cells. The expressed PD-1-Fc fusion protein targets and binds to programmed death ligand 1 (PD-L1; cluster of differentiation 274; CD274; programmed cell death-1 ligand 1) expressed on tumor cells, thereby halting PD-1/PD-L1-mediated signaling. This may decrease T-cell exhaustion and may enhance T-cell activity against the PD-L1-expressing tumor cells. BCMA, a receptor for both a proliferation-inducing ligand (APRIL) and B-cell activating factor (BAFF), is a member of the tumor necrosis factor receptor superfamily (TNFRSF). BCMA is found on the surfaces of plasma cells, is overexpressed on malignant plasma cells and plays a key role in plasma cell proliferation and survival. PD-1, an immune checkpoint receptor expressed on T-cells, plays a key role in tumor immune evasion by binding to its ligand PD-L1 expressed on tumor cells."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1179463", "l": "Endothelial cell of hepatic sinusoid", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C3899624", "l": "Circulating Adipose Stromal Cell", "d": []}, {"i": "NCIT:C116009", "l": "Circulating Adipose Stromal Cell", "d": ["A precursor of fat-storing cells, which is located in the blood circulation. Detection of these cells is associated with obesity and elevated risk for obesity-related neoplastic diseases such as breast, colon and prostate carcinomas."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1979672", "l": "Cells.CD4+CD7-", "d": []}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "CL:0002248", "l": "pluripotent stem cell", "d": ["A pluripotent stem cell has the ability to form cells from all three germ layers (ectoderm, mesoderm, and endoderm). However, unlike totipotent stem cells, they cell can not generate all the cells of the whole organism such as placenta."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5707731", "l": "Autologous Anti-CLDN6 CAR-NK Cells", "d": []}, {"i": "NCIT:C188377", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1182622", "l": "Definitive germ cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1267902", "l": "Lymphocyte positive for CD29 antigen", "d": []}, {"i": "SNOMEDCT:117573004", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5216246", "l": "Lymphocytes.plasmacytoid|NCnc|Pt|Bld", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5454853", "l": "Not specified MC", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1267992", "l": "Lymphocyte positive for CD106 antigen", "d": []}, {"i": "SNOMEDCT:117432003", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C4727433", "l": "Allogeneic CD34-positive E-rosetted T-cell Depleted Peripheral Blood Stem Cells", "d": []}, {"i": "NCIT:C153885", "l": "Allogeneic CD34-positive E-rosetted T-cell Depleted Peripheral Blood Stem Cells", "d": ["A preparation of CD34+ selected peripheral blood stem cells (PBSCs) that are depleted of T-cells via erythrocyte rosetting (E-rosetting) and intended for allogeneic stem cell transplant. Administration of this particular preparation of CD34+E- T-cell depleted PBSCs may potentially reduce the occurrence of graft-versus-host disease (GvHD) without increasing the risk of graft failure or poor graft function"]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4552764", "l": "Mesenchymal Progenitor Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C4086542", "l": "Lentivirus Vector CCR5 shRNA/TRIM5alpha/TAR Decoy-transduced Autologous CD34-positive Hematopoietic Progenitor Cells", "d": []}, {"i": "NCIT:C123931", "l": "Lentivirus Vector CCR5 shRNA/TRIM5alpha/TAR Decoy-transduced Autologous CD34-positive Hematopoietic Progenitor Cells", "d": ["Autologous, CD34-positive hematopoietic progenitor cells (HPCs) transduced with a lentiviral vector encoding three anti-human immunodeficiency virus (HIV) genes: a short hairpin RNA (shRNA) that targets human chemokine receptor 5 (CCR5), a human/rhesus macaque chimeric tripartite motif-containing protein 5 alpha isoform (TRIM5alpha), and a TAT activation response (TAR) decoy, as well as a pre-selective cell-surface marker, which is a truncated and mutated form of human CD25, used to potentially provide resistance against human immunodeficiency virus (HIV) infection. Human autologous CD34-positive HPCs are isolated and transduced ex vivo with the lentiviral vector. Upon pre-selection, purification using CD25 immunomagnetic separation, and subsequent administration of effectively transduced HPCs, the HPCs display 3 separate mechanisms of action against HIV infection: CCR5 shRNA binds to CCR5 mRNA and inhibits the expression of CCR5, a HIV-1 co-receptor that mediates HIV attachment and host cell entry; TRIM5alpha prevents HIV genome integration upon cell entry; and the TAR decoy binds to the HIV TAT protein and prevents TAT-dependent viral gene transcription, thereby preventing HIV replication. Upon transfer of the lentivirus vector CCR5 shRNA/TRIM5alpha/TAR decoy-transduced autologous CD34-positive HPCs into the patient, the HPCs are resistant to HIV entry and replication and could provide long-term protection against both HIV infection and HIV-associated cancers."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1183328", "l": "Cell body of bipolar cell of retina", "d": []}]}
{"type": "biolink:Cell", "ic": "80.17194633000733", "identifiers": [{"i": "CL:0002520", "l": "nephrocyte", "d": ["An insect excretory cell that regulates hemolymph composition by filtration and filtrate endocytosis."]}]}
{"type": "biolink:Cell", "ic": "79.541110464886842", "identifiers": [{"i": "CL:0002431", "l": "CD4-positive, CD8-intermediate double-positive thymocyte", "d": ["A double-positive thymocyte that is undergoing positive selection, has high expression of the alpha-beta T cell receptor, is CD69-positive, and is in the process of down regulating the CD8 co-receptor."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0001013", "l": "mature interstitial dendritic cell", "d": ["Mature interstitial dendritic cell is a interstitial dendritic cell that is CD80-high, CD86-high, MHCII-high and is CD83-positive."]}]}
{"type": "biolink:Cell", "ic": "72.269651791985453", "identifiers": [{"i": "CL:4023040", "l": "L2/3-6 intratelencephalic projecting glutamatergic neuron", "d": ["A intratelencephalic-projecting glutamatergic neuron with a soma found in cortical layers L2/3-6"]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0599229", "l": "cell wall defective microbial form", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157469", "l": "CD3+HLA-DR+ cells | Tissue and Smears | Cell markers", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0009049", "l": "smooth muscle cell of high endothelial venule of lymph node", "d": ["A layer of smooth muscle cells that forms the outer layer of the high endothelial venule of lymph node and pumps to allow flow of lymph fluid carrying lymphocytes."]}]}
{"type": "biolink:Cell", "ic": "90.82444074280258", "identifiers": [{"i": "UMLS:C1519381", "l": "Neoplastic Small to Medium-Sized B-Lymphocyte with Pale Cytoplasm", "d": []}, {"i": "NCIT:C36991", "l": "Neoplastic Small to Medium-Sized B-Lymphocyte with Pale Cytoplasm", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5706295", "l": "Orca-T", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0009069", "l": "CD8aa(II) thymocyte", "d": ["An unconventional T lymphocyte population within the thymic medulla that expresses both alpha/beta and gamma/delta T cell signatures."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0228086", "l": "Glioblast", "d": []}, {"i": "SNOMEDCT:15837001", "d": []}]}
{"type": "biolink:Cell", "ic": "78.96520244130248", "identifiers": [{"i": "UMLS:C1708908", "l": "Malignant Small Squamous Cell", "d": []}, {"i": "NCIT:C54207", "l": "Malignant Small Squamous Cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1267811", "l": "Lymphocyte positive for CD1A antigen", "d": []}, {"i": "SNOMEDCT:117514000", "d": []}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "CL:0000600", "l": "heterokaryon", "d": ["A fungal cell with two or more genetically distinct nuclei."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4518152", "l": "Population of all spermatozoa with amorphous head in portion of fluid", "d": []}, {"i": "SNOMEDCT:725235007", "d": []}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "UMLS:C0333721", "l": "Fusiform cell", "d": []}, {"i": "NCIT:C32645", "l": "Fusiform Cell", "d": ["A cell with spindle-like morphologic characteristics.."]}, {"i": "SNOMEDCT:15409002", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002190", "l": "squamous cell of epidermis", "d": ["A flat keratinocyte immediately below the cornified layer."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5171657", "l": "Lymphocytes | Blood | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "ic": "55.822633861886644", "identifiers": [{"i": "UMLS:C1514044", "l": "Neoplastic Neuroendocrine Cell", "d": []}, {"i": "NCIT:C36761", "l": "Neoplastic Neuroendocrine Cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0483190", "l": "CD34+DR+", "d": []}]}
{"type": "biolink:Cell", "ic": "77.061101857006449", "identifiers": [{"i": "UMLS:C1515408", "l": "Therapeutic Tumor Infiltrating Lymphocytes", "d": []}, {"i": "NCIT:C28699", "l": "Therapeutic Tumor Infiltrating Lymphocytes", "d": ["A preparation of cells, consisting of autologous tumor infiltrating lymphocytes, that are manipulated in vitro and, upon administration in vivo, re-infiltrate the tumor to initiate tumor cell lysis. In vitro, therapeutic tumor-infiltrating lymphocytes (TILs) are isolated from tumor tissue and cultured with lymphokines such as interleukin-2; the therapeutic TILs are then infused into the patient, where, after re-infiltration of the tumor, they may induce lysis of tumor cells and tumor regression.  The use of therapeutic TILs is considered a form of adoptive immunotherapy."]}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "CL:0002674", "l": "H minus", "d": ["A S. pombe mating type determined by the mat1-Mc and mat1-Mi on the mat1 locus."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5401601", "l": "Human Embryonic Stem Cell-derived M Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "77.061101857006449", "identifiers": [{"i": "UMLS:C1515880", "l": "Activated Mature Cytotoxic T-Lymphocyte", "d": []}, {"i": "NCIT:C39687", "l": "Activated Mature Cytotoxic T-Lymphocyte", "d": ["A white blood cell that is derived from a lymphocyte stem cell matured in the thymus and characterized by a CD8 marker on the surface and an antigen-specific T cell receptor which recognizes antigens in the context of MHC class I."]}]}
{"type": "biolink:Cell", "ic": "92.728541327098611", "identifiers": [{"i": "UMLS:C1513066", "l": "Neoplastic Medium-Sized B-Lymphocyte with Eccentric Basophilic Cytoplasm", "d": []}, {"i": "NCIT:C37006", "l": "Neoplastic Medium-Sized B-Lymphocyte with Eccentric Basophilic Cytoplasm", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4322821", "l": "CD13+ T lymphocyte", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5761849", "l": "Zevor-cel", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4053624", "l": "Lifileucel", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0882892", "l": "Cell positive for CD5 antigen", "d": []}, {"i": "SNOMEDCT:116746008", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5691290", "l": "Airway M Cells", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0225468", "l": "Structure of posterior cells of ethmoid sinus", "d": []}, {"i": "SNOMEDCT:5890002", "d": []}]}
{"type": "biolink:Cell", "ic": "90.82444074280258", "identifiers": [{"i": "UMLS:C1512246", "l": "Goteborg ES Cell Line", "d": []}, {"i": "NCIT:C20263", "l": "Goteborg ES Cell Line", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1440264", "l": "Cells.CD18", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4696636", "l": "Cells.CD4+CD25+CD45RA+CD127Low+", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0004218", "l": "H2 horizontal cell", "d": ["A horizontal cell with a small cell body, thin dendrites, and small dendritic arbor."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5426958", "l": "Epithelial cells.squamous | Bronchial | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "ic": "92.728541327098611", "identifiers": [{"i": "UMLS:C3811668", "l": "Circulating Plasma Cell", "d": []}, {"i": "NCIT:C114278", "l": "Circulating Plasma Cell", "d": ["A plasma cell myeloma-derived cell found in the peripheral blood."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5419436", "l": "Autologous Anti-CD19/CD20 Bispecific Nanobody-based CAR-T cells", "d": []}, {"i": "NCIT:C172057", "l": "Autologous Anti-CD19/CD20 Bispecific Nanobody-based CAR-T cells", "d": ["A preparation of autologous T-lymphocytes engineered to express a chimeric antigen receptor (CAR) that is nanobody-based and specific for the two tumor-associated antigens (TAAs) cluster of differentiation 19 (CD19) and CD20, with potential immunostimulating and antineoplastic activities. Upon administration, the autologous anti-CD19/CD20 bispecific nanobody-based CAR-T cells target and bind to CD19- and CD20-expressing tumor B-cells. This induces selective toxicity in tumor B-cells expressing these TAAs. Both CD19 and CD20 are B-cell-specific cell surface antigens overexpressed in B-cell lineage malignancies. Targeting both CD19 and CD20 may prevent tumor cell antigen escape and relapse."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C4086901", "l": "Therapeutic gamma delta T-lymphocytes", "d": []}, {"i": "NCIT:C124644", "l": "Therapeutic gamma delta T-lymphocytes", "d": ["A subset of therapeutic autologous T-lymphocytes that express a T-cell receptor (TCR) composed of one gamma chain and one delta chain, with potential immunomodulating and antineoplastic activities. Upon administration of the therapeutic gamma delta T-lymphocytes, these cells secrete interferon-gamma (IFN-g), and exert direct killing of tumor cells. In addition, these cells activate the immune system to exert a cytotoxic T-lymphocyte (CTL) response against tumor cells. Gamma delta T-lymphocytes play a key role in the activation of the immune system and do not require major histocompatibility complex (MHC)-mediated antigen presentation to exert their cytotoxic effect."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C3830410", "l": "DNR-expressing Nasopharyngeal Carcinoma-specific Cytotoxic T-Lymphocytes", "d": []}, {"i": "NCIT:C114378", "l": "DNR-expressing Nasopharyngeal Carcinoma-specific Cytotoxic T-Lymphocytes", "d": ["A preparation of autologous, dominant-negative receptor (DNR)-expressing nasopharyngeal carcinoma (NPC)-specific cytotoxic T-lymphocytes (CTLs), with potential antineoplastic activity. The DNR-expressing NPC-specific CTLs specifically target Epstein-Barr virus (EBV) nuclear antigen 1 (EBNA1), latent membrane proteins (LMP) and BamHIA rightward frame 1 (BARF1), and are transduced with a retroviral vector expressing DNR, a dominant-negative form of the transforming growth factor beta (TGFb) receptor, which blocks TGF-beta-mediated signaling. Upon administration, the CTLs recognize and target NPC cells, which may result in both CTL-mediated cell lysis and the inhibition of tumor cell proliferation. Tumor-expressed TGF-beta inhibits T-lymphocyte activation and expansion; resistance to TGF-beta allows for optimal CTL activity. EBV infection plays a key role in NPC tumorigenesis."]}]}
{"type": "biolink:Cell", "ic": "90.82444074280258", "identifiers": [{"i": "CL:0007002", "l": "precementoblast", "d": ["Skeletogenic cell that has the potential to develop into a cementoblast."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1440294", "l": "Cells.CD32", "d": []}]}
{"type": "biolink:Cell", "ic": "92.728541327098611", "identifiers": [{"i": "CL:1000324", "l": "duodenal goblet cell", "d": ["A goblet cell that is part of the epithelium proper of duodenum."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002146", "l": "clear cell of eccrine sweat gland", "d": ["A sweat producing cell of eccrine sweat glands. Pyramidal in shape, with its base resting on the basal lamina or myoepitheliocytes, and its microvillus-covered apical plasma membrane line up the intercellular canaliculi. Cell is not stained by hematoxylin or eosin."]}]}
{"type": "biolink:Cell", "ic": "57.616234936174635", "identifiers": [{"i": "UMLS:C0027836", "l": "Neuroglia", "d": []}, {"i": "NCIT:C12615", "l": "Glial Cell", "d": ["A non-neuronal cell of the nervous system. Glial cells have diverse roles, including in regulation of neuronal survival and differentiation, maintenance of ion and neurotransmitter concentrations in the neuronal environment, synapse formation, and support of synaptic interactions and electrical signal propagation."]}, {"i": "MESH:D009457", "l": "Neuroglia", "d": []}, {"i": "SNOMEDCT:2156000", "d": []}, {"i": "SNOMEDCT:58861006", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4511822", "l": "Population of all spermatozoa in portion of fluid", "d": []}, {"i": "SNOMEDCT:726440009", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5216304", "l": "Other cells|NCnc|Pt|Bld", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157515", "l": "CD3-CD16+ cells | Blood | Cell markers", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1512133", "l": "ES04", "d": []}, {"i": "NCIT:C20252", "l": "ES04", "d": ["Provider: ES Cell International Pte Ltd., Melbourne, Australia. Information from provider and not independently verified by NIH: Cells are positive for cell markers Oct-4, SSEA-4, TRA-1-60, GCTM-2, and alkaline phosphatase activity; Cells are negative for cell marker SSEA-1; Give rise to teratomas containing derivatives of three germ layers in SCID mice; Differentiate in vitro into extraembryonic and somatic cell lineages; Neural progenitor cells may be isolated from differentiating ES cell cultures and induced to form mature neurons; Available for distribution. This cell line meets the criteria for the use of human embryonic stem cells by federally funded researchers."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0524977", "l": "Intestinal L Cells", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0333722", "l": "Tadpole cell", "d": []}, {"i": "SNOMEDCT:112657009", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0000777", "l": "mesangial phagocyte", "d": ["A tissue-resident macrophage of the renal glomerular mesangium involved in the disposal and degradation of filtration residues, presentation of antigen to T cells and in tissue remodeling."]}]}
{"type": "biolink:Cell", "ic": "72.577556932535018", "identifiers": [{"i": "CL:4023154", "l": "myelinating glial cell", "d": ["A glial cell that myelinates axonal processes."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1440291", "l": "Cells.CD3+DR+", "d": []}]}
{"type": "biolink:Cell", "ic": "85.457082654197222", "identifiers": [{"i": "CL:0000394", "l": "plasmatocyte", "d": ["A phagocytic hemocyte, responsible for the engulfment of small particles, microbes, and apoptotic tissue debris. It may also secretes antimicrobial peptides and contribute to the production and secretion of proteins of the hemolymph."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0229471", "l": "Phalangeal cell of cochlea", "d": []}, {"i": "SNOMEDCT:4799000", "d": []}]}
{"type": "biolink:Cell", "ic": "86.236661114203869", "identifiers": [{"i": "UMLS:C1512105", "l": "Dysplastic Granulocyte", "d": []}, {"i": "NCIT:C37051", "l": "Dysplastic Granulocyte", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C3640296", "l": "Allogeneic GM-CSF-secreting Tumor Vaccine PANC 10.05 pcDNA-1/GM-Neo", "d": []}, {"i": "NCIT:C101892", "l": "Allogeneic GM-CSF-secreting Tumor Vaccine PANC 10.05 pcDNA-1/GM-Neo", "d": ["An allogeneic cancer vaccine composed of lethally irradiated, whole pancreatic cancer cells transfected with a plasmid carrying the gene for cytokine granulocyte-macrophage colony-stimulating factor (GM-CSF), with potential immunostimulating and antineoplastic activities. Allogeneic GM-CSF-secreting tumor vaccine PANC 10.05 pcDNA-1/GM-Neo secretes GM-CSF thereby activating dendritic cells, promoting antigen presentation to B- and T-cells, and promoting a cytotoxic T-lymphocyte (CTL) response. This may eventually kill tumor cells. The pancreatic tumor cells are derived from the PANC 10.05 tumor cell line."]}]}
{"type": "biolink:Cell", "ic": "89.347505587204751", "identifiers": [{"i": "UMLS:C1881546", "l": "Malignant Epithelial Cell with Vesicular Nucleus, Distinct Nucleolus, and Abundant Pink Cytoplasm", "d": []}, {"i": "NCIT:C60664", "l": "Malignant Epithelial Cell with Vesicular Nucleus, Distinct Nucleolus, and Abundant Pink Cytoplasm", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C0333855", "l": "Small cleaved cell", "d": []}, {"i": "NCIT:C12915", "l": "Small Cleaved Follicle Center Cell", "d": ["A lymphoid cell of follicular center cell origin that has an irregularly shaped nucleus with clumped chromatin, absent nucleoli, and one or more clefts in the nuclear membrane."]}, {"i": "SNOMEDCT:89494004", "d": []}]}
{"type": "biolink:Cell", "ic": "92.728541327098611", "identifiers": [{"i": "UMLS:C1519515", "l": "Tingible Body Macrophage", "d": []}, {"i": "NCIT:C36834", "l": "Tingible Body Macrophage", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5555574", "l": "Autologous Anti-CD30 CAR T Cells HSP-CAR30", "d": []}, {"i": "NCIT:C179274", "l": "Autologous Anti-CD30 CAR T Cells HSP-CAR30", "d": ["A preparation of autologous T-lymphocytes that have been genetically modified to express a chimeric antigen receptor (CAR) specific for the CD30 antigen, with potential immunostimulating and antineoplastic activities. Upon administration, autologous anti-CD30 CAR T cells HSP-CAR30 specifically recognize and bind to CD30-expressing tumor cells, resulting in tumor cell lysis. CD30, a cell surface receptor and a member of the tumor necrosis factor (TNF) receptor superfamily, is transiently expressed on activated lymphocytes and is constitutively expressed in hematologic malignancies."]}]}
{"type": "biolink:Cell", "ic": "45.929066513502235", "identifiers": [{"i": "CL:0000034", "l": "stem cell", "d": ["A relatively undifferentiated cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:1001590", "l": "epididymis glandular cell", "d": ["Glandular cell of epididymal epithelium."]}]}
{"type": "biolink:Cell", "ic": "58.788005074184341", "identifiers": [{"i": "CL:0000167", "l": "peptide hormone secreting cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157517", "l": "CD3-CD16+ cells | Bone marrow | Cell markers", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1267806", "l": "LEU M3+ lymphocyte", "d": []}, {"i": "SNOMEDCT:117510009", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1440252", "l": "Cells.CD122", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0314594", "l": "Colony-forming unit, monocyte", "d": []}]}
{"type": "biolink:Cell", "ic": "57.749057458637679", "identifiers": [{"i": "CL:0010012", "l": "cerebral cortex neuron", "d": ["A CNS neuron of the cerebral cortex."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1514716", "l": "Raji Cell", "d": []}, {"i": "NCIT:C36741", "l": "Raji Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "90.82444074280258", "identifiers": [{"i": "CL:1000370", "l": "transitional myocyte of left branch of atrioventricular bundle", "d": ["A transitional myocyte that is part of the left branch of atrioventricular bundle."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2709114", "l": "Cells.CD138+Kappa+", "d": []}]}
{"type": "biolink:Cell", "ic": "48.222410381252232", "identifiers": [{"i": "UMLS:C1514101", "l": "Neoplastic Squamous Cell", "d": []}, {"i": "NCIT:C36760", "l": "Neoplastic Squamous Cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2338973", "l": "Goblet cell of epithelium of pyloric gland", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:1000315", "l": "principal gastric gland goblet cell", "d": ["A goblet cell that is part of the epithelium of principal gastric gland."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C3642444", "l": "CD19CAR-CD3zeta-expressing Autologous T lymphocytes", "d": []}, {"i": "NCIT:C88266", "l": "CD19CAR-CD3zeta-expressing Autologous T lymphocytes", "d": ["Autologous T-lymphocytes transduced with a modified lentiviral vector expressing a chimeric antigen receptor (CAR) consisting of an anti-CD19 scFv (single chain variable fragment) and the zeta chain of the TCR/CD3 complex (CD3-zeta), with potential immunomodulating and antineoplastic activities. Upon transfusion, CD19CAR-CD3zeta-expressing autologous T-lymphocytes are directed to CD19-expressing tumor cells, thereby inducing a selective toxicity only in these tumor cells. The CD19 antigen is a B-cell specific cell surface antigen expressed in all B-cell lineage malignancies. CD3-zeta (or CD247) is a transmembrane signaling adaptor polypeptide that regulates the assembly of complete T-cell receptor complexes and their expression on the cell surface."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157283", "l": "CD123 blasts | Bone marrow | Cell markers", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5163444", "l": "Eosinophils | Pleural fluid | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "ic": "56.245343708512259", "identifiers": [{"i": "UMLS:C1515078", "l": "Supporting Cell of the Nervous System", "d": []}, {"i": "NCIT:C33704", "l": "Supporting Cell of the Nervous System", "d": ["A cell that serves to provide support and protection and perhaps contribute to the nutrition of principal or other cells of the nervous system."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0229610", "l": "Tissue eosinophil", "d": []}, {"i": "SNOMEDCT:55109005", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1512130", "l": "ES01 (cell line)", "d": []}, {"i": "NCIT:C20249", "l": "ES01", "d": ["Provider: ES Cell International Pte Ltd., Melbourne, Australia. Information from provider and not independently verified by NIH: Cells are positive for cell markers Oct-4, SSEA-4, TRA-1-60, GCTM-2, and alkaline phosphatase activity; Cells are negative for cell marker SSEA-1; Give rise to teratomas containing derivatives of three germ layers in SCID mice; Differentiate in vitro into extraembryonic and somatic cell lineages; Neural progenitor cells may be isolated from differentiating ES cell cultures and induced to form mature neurons; Available for distribution. This cell line meets the criteria for the use of human embryonic stem cells by federally funded researchers."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C2347347", "l": "Ad5F35-LMP1/LMP2-Transduced Autologous Dendritic Cells", "d": []}, {"i": "NCIT:C73995", "l": "Ad5F35-LMP1/LMP2-Transduced Autologous Dendritic Cells", "d": ["Autologous dendritic cells (DCs) transduced with the replication-deficient adenoviral vector Ad5F53 encoding the Epstein-Barr virus (EBV) transmembrane latent membrane proteins 1 and 2 (LMP1/LMP2) with potential immunostimulatory activity. Vaccination with Ad5F35-LMP1/LMP2-transduced autologous dendritic cells may stimulate a specific cytotoxic T-lymphocyte (CTL) response against LMP1- and LMP2-expressing tumor positive cells, resulting in tumor cell lysis and inhibition of tumor cell proliferation. LMP1 and LMP2 are expressed in various malignancies including nasopharyngeal cancer and EBV-positive Hodgkins disease."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1180272", "l": "Myoepithelial cell of lactiferous duct", "d": []}]}
{"type": "biolink:Cell", "ic": "54.716941812655833", "identifiers": [{"i": "UMLS:C1513929", "l": "Neoplastic B-Lymphocyte", "d": []}, {"i": "NCIT:C38640", "l": "Neoplastic B-Lymphocyte", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5170917", "l": "Leukocytes | Blood | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "ic": "92.728541327098611", "identifiers": [{"i": "CL:0002126", "l": "CD25-positive, CD27-positive immature gamma-delta T cell", "d": ["A CD25-positive, CD27-positive immature gamma-delta T cell found in the thymus that has an immature phenotype (i.e. CD24-high, CD25-high, CD62L-high, CD44-high, CD2-low, CD5-low)."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002415", "l": "immature Vgamma1.1-positive, Vdelta6.3-positive thymocyte", "d": ["A Vgamma1.1-positive, Vdelta6.3-positive thymocyte that is CD24-positive."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0333816", "l": "Hypersegmented leukocyte", "d": []}, {"i": "SNOMEDCT:24481008", "d": []}]}
{"type": "biolink:Cell", "ic": "84.75972595860604", "identifiers": [{"i": "UMLS:C1709673", "l": "Primitive Malignant Skeletal Spindle Cell", "d": []}, {"i": "NCIT:C49201", "l": "Primitive Malignant Skeletal Spindle Cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0553712", "l": "Marrow monocytoid cell", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5706428", "l": "Autologous Tumor Infiltrating Lymphocytes LM103", "d": []}, {"i": "NCIT:C187659", "l": "Autologous Tumor Infiltrating Lymphocytes LM103", "d": ["A preparation of autologous tumor infiltrating lymphocytes (TILs) derived from each patient's resected tumor and expanded ex vivo, with potential immunomodulating and antineoplastic activities. Upon administration back into the patient, the autologous TILs LM103 specifically recognize and kill the patient's tumor cells."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1267821", "l": "T lymphocyte positive for both CD3 antigen and CD4 antigen", "d": []}, {"i": "SNOMEDCT:115396002", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0682698", "l": "Projection neuron", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5776719", "l": "Erythrocytes.parasite sp infected", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1179115", "l": "Basal proper cell of olfactory epithelium", "d": []}]}
{"type": "biolink:Cell", "ic": "62.426889726972838", "identifiers": [{"i": "CL:0000225", "l": "anucleate cell", "d": ["A cell that lacks a nucleus."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0227897", "l": "Structure of hilar cell of ovary", "d": []}, {"i": "SNOMEDCT:79891005", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0004225", "l": "spider amacrine cell", "d": ["A broadly stratifying amacrine cell with a small dendritic field, straight dendrites and post-synaptic terminals in S1, S2, and S3."]}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "CL:2000075", "l": "anterior visceral endoderm cell", "d": ["Any endodermal cell that is part of a anterior visceral endoderm."]}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "CL:4023022", "l": "canopy lamp5 GABAergic cortical interneuron (Mmus)", "d": ["A Lamp5 GABAergic cortical interneuron that has extended axons in the surface of L1. Canopy Lamp5 cells resemble neurogliaform cells in having elongated horizontal axonal arbors largely confined to L1; but the dendritic arbors are wider and have fewer branches, while the axon is less tortuous and extends further from the soma"]}]}
{"type": "biolink:Cell", "ic": "54.738189878797783", "identifiers": [{"i": "UMLS:C1513029", "l": "Mature T-Lymphocyte", "d": []}, {"i": "NCIT:C33061", "l": "Mature T-Lymphocyte", "d": ["A lymphocyte derived from a pre T-lymphocyte in the thymus and stored in secondary lymphoid organs, bone marrow, and lymph nodes. It circulates in the bloodstream and the lymphatic system, where it searches for and attacks particular foreign or abnormal cells. A mature T lymphocyte has T cell receptors and other surface proteins on its cell surface."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4697020", "l": "Cells.CD25-CD127+", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C0014355", "l": "Argentaffin Cell", "d": []}, {"i": "NCIT:C12575", "l": "Enterochromaffin Cell", "d": ["The most abundant and widely distributed type of enteroendocrine cell found in the gastrointestinal tract. It is characterized by serotonin production and an affinity to binding silver and chromium salts."]}, {"i": "NCIT:C32140", "l": "Argentaffin Cell", "d": ["An enteroendocrine cell located in the basilar portions of the glands of the gastrointestinal tract. The granules in the cell stain readily with chromium and silver salts without pretreatment with a reducing agent."]}, {"i": "MESH:D004759", "l": "Enterochromaffin Cells", "d": []}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "UMLS:C0225700", "l": "Type-II Pneumocytes", "d": []}, {"i": "NCIT:C32055", "l": "Alveolar Cell Type II", "d": ["A pleomorphic cell of the pulmonary alveolar epithelium that secretes surfactant and is distinguished by abundant cytoplasm containing numerous lipid-rich multilamellar bodies."]}, {"i": "SNOMEDCT:52782001", "d": []}]}
{"type": "biolink:Cell", "ic": "79.849015605436421", "identifiers": [{"i": "UMLS:C0025171", "l": "Megaloblasts", "d": []}, {"i": "NCIT:C12524", "l": "Megaloblast", "d": []}, {"i": "MESH:D008534", "l": "Megaloblasts", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5706399", "l": "Autologous BAFF-expressing CAR T Cells LMY-920", "d": []}, {"i": "NCIT:C187330", "l": "Autologous BAFF-expressing CAR T Cells LMY-920", "d": ["A preparation of autologous cluster of differentiation 4 (CD4) -and CD8 positive T-lymphocytes that are genetically engineered, using the non-viral transposon system, to express a chimeric antigen receptor (CAR) expressing the B-cell activating factor (BAFF) ligand and targeting BAFF receptor family members, with potential immunostimulating and antineoplastic activities. Upon administration, the autologous BAFF-expressing CAR T cells LMY-920 are directed to, specifically bind to, and induce selective toxicity in tumor cells expressing any of the three BAFF receptor family members, including BAFF receptor (BAFF-R), B-cell maturation antigen (BCMA), and transmembrane activator and calcium modulator and cyclophilin ligand interactor (TACI). Almost all B cell cancers are reported to express at least one of these three receptors which play a key role in the regulation of peripheral B-cell survival."]}]}
{"type": "biolink:Cell", "ic": "50.988775076554816", "identifiers": [{"i": "CL:0000076", "l": "squamous epithelial cell", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C2986401", "l": "GITRL RNA-transfected Autologous Dendritic Cell Vaccine", "d": []}, {"i": "NCIT:C94216", "l": "GITRL RNA-transfected Autologous Dendritic Cell Vaccine", "d": ["An autologous dendritic cell (DC) cancer vaccine with potential immunostimulatory activity. GITRL RNA-transfected autologous DC vaccine is prepared by transfecting DCs with RNAs encoding tumor necrosis factor (ligand) superfamily, member 18 (TNFSF18 or GlTRL); expression of GlTRL results in modulating T lymphocyte survival in peripheral tissues. Co-vaccination of this vaccine with melanoma antigen specific vaccine may eliminate the adverse effects associated with systemic administration of immune modulators, while also enhancing vaccine-induced immune responses."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5761821", "l": "Allogeneic gene edited BCMA-directed CAR T cells", "d": []}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "CL:0002122", "l": "B220-positive CD38-positive IgG-negative class switched memory B cell", "d": ["A B220-positive CD38-positive IgG-negative memory B cell is a CD38-positive IgG-negative class switched memory B cell that lacks IgG on the cell surface with the phenotype B220-positive, CD38-positive, and IgG-negative."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5171965", "l": "Malignant cells | Synovial fluid | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "UMLS:C1883031", "l": "Signet Ring Melanoma Cell", "d": []}, {"i": "NCIT:C62402", "l": "Signet Ring Melanoma Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C4683473", "l": "Autologous Anti-CD19 Chimeric Antigen Receptor T-cells C-CAR011", "d": []}, {"i": "NCIT:C141050", "l": "Autologous Anti-CD19 Chimeric Antigen Receptor T-cells C-CAR011", "d": ["A proprietary preparation of autologous T-lymphocytes that have been genetically modified and transduced with a lentiviral vector expressing a second-generation chimeric antigen receptor (CAR) targeting the tumor-associated antigen (TAA) CD19 and containing, as of yet undisclosed, costimulatory signaling domains, with potential immunostimulating and antineoplastic activities. Upon administration, autologous anti-CD19 CAR T-cells C-CAR011 target and bind to CD19-expressing tumor cells, thereby inducing selective toxicity in CD19-expressing tumor cells. CD19 antigen is a B-cell specific cell surface antigen expressed in all B-cell lineage malignancies."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C3484293", "l": "Basophils+Mast cells", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002562", "l": "hair germinal matrix cell", "d": ["An epidermal cell that is part of the germinal matrix."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5447417", "l": "Tumor-Infiltrating Follicular Helper T Cell", "d": []}, {"i": "NCIT:C176756", "l": "Tumor-Infiltrating Follicular Helper T Cell", "d": ["A follicular helper T cell that has migrated into a tumor."]}]}
{"type": "biolink:Cell", "ic": "92.728541327098611", "identifiers": [{"i": "CL:0000374", "l": "trichogen cell", "d": ["An epidermal cell that is part of a cell cluster organ of the insect integument (such as a sensillum) and that secretes a cuticular specialization, often in the form of a hair, bristle, peg or scale. The base of this specialization is often surrounded by a socket produced by a closely associated tormogen cell."]}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "CL:0000876", "l": "splenic white pulp macrophage", "d": ["A splenic macrophage found in the white pulp of the spleen. Markers include F4/80-negative, CD68-positive, and macrosialin-positive."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5216235", "l": "Leukocytes|NCnc|Pt|Dial fld prt", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0597032", "l": "Neoplastic Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "89.347505587204751", "identifiers": [{"i": "CL:0000509", "l": "gastrin secreting cell", "d": ["A peptide hormone secreting cell that secretes gastrin."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1440242", "l": "Cells.CD115", "d": []}]}
{"type": "biolink:Cell", "ic": "70.83295242545627", "identifiers": [{"i": "UMLS:C1513927", "l": "Neoplastic B-Immunoblast", "d": []}, {"i": "NCIT:C37010", "l": "Neoplastic B-Immunoblast", "d": []}]}
{"type": "biolink:Cell", "ic": "92.728541327098611", "identifiers": [{"i": "CL:0000928", "l": "activated CD4-negative, CD8-negative type I NK T cell", "d": ["A type I NK T cell that has been recently activated, secretes interferon-gamma and interleukin-4, and has phenotype CD4-negative, CD8-negative, CD69-positive, and downregulated NK markers."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C0677856", "l": "autologous lymphocytes", "d": []}, {"i": "NCIT:C12939", "l": "Autologous Lymphocyte", "d": []}]}
{"type": "biolink:Cell", "ic": "92.728541327098611", "identifiers": [{"i": "CL:4023125", "l": "KNDy neuron", "d": ["A hypothalamus kisspeptin neuron that coexpresses kisspeptin, neurokinin B and dynorphin."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2963402", "l": "Cells.CD4+CD26-", "d": []}]}
{"type": "biolink:Cell", "ic": "77.712653754434029", "identifiers": [{"i": "CL:2000022", "l": "cardiac septum cell", "d": ["Any native cell that is part of a cardiac septum."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1717630", "l": "Bizarre cells", "d": []}]}
{"type": "biolink:Cell", "ic": "92.728541327098611", "identifiers": [{"i": "CL:0001014", "l": "CD1a-positive Langerhans cell", "d": ["CD1a-positive Langerhans cell is a Langerhans_cell that is CD1a-positive and CD324-positive."]}]}
{"type": "biolink:Cell", "ic": "92.728541327098611", "identifiers": [{"i": "CL:0003040", "l": "M9 retinal ganglion cell", "d": ["A monostratified retinal ganglion cell with large soma and large dendritic field, with medium dendritic arbor, and has dendrites in layers 1 and 5."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1183327", "l": "Mesothelial cell of visceral peritoneum", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1267834", "l": "Lymphocyte positive for both CD3 antigen and DR antigen", "d": []}, {"i": "SNOMEDCT:117524008", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157325", "l": "CD16 cells | Blood | Cell markers", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1183210", "l": "Set of tubal air cells", "d": []}]}
{"type": "biolink:Cell", "ic": "84.75972595860604", "identifiers": [{"i": "UMLS:C1511247", "l": "Bone Marrow Stem Cell at the Earliest Stage of Myeloid Differentiation", "d": []}, {"i": "NCIT:C41061", "l": "Bone Marrow Stem Cell at the Earliest Stage of Myeloid Differentiation", "d": ["An undifferentiated cell which can undergo division and can give rise to any of the early stage myeloid cells."]}]}
{"type": "biolink:Cell", "ic": "72.473322228407739", "identifiers": [{"i": "CL:0000182", "l": "hepatocyte", "d": ["The main structural component of the liver. They are specialized epithelial cells that are organized into interconnected plates called lobules. Majority of cell population of liver, polygonal in shape, arranged in plates or trabeculae between sinusoids; may have single nucleus or binucleated."]}]}
{"type": "biolink:Cell", "ic": "75.105493098994543", "identifiers": [{"i": "UMLS:C1711298", "l": "Malignant Chondrocyte", "d": []}, {"i": "NCIT:C53478", "l": "Malignant Chondrocyte", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002229", "l": "light chief cell of parathyroid gland", "d": ["A chief cell that is bigger than dark chief cells and has a larger and lighter nucleus and a cytoplasm with few granules."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1717663", "l": "Cells.CD20+FMC7+", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5707907", "l": "Firzotemcel", "d": []}, {"i": "NCIT:C188605", "d": []}]}
{"type": "biolink:Cell", "ic": "71.079643100360357", "identifiers": [{"i": "UMLS:C0029418", "l": "Osteoblasts", "d": []}, {"i": "NCIT:C12568", "l": "Osteoblast", "d": ["Cells which secrete an extracellular matrix into which hydroxyapaetite crystals are deposited to form bone."]}, {"i": "MESH:D010006", "l": "Osteoblasts", "d": []}, {"i": "SNOMEDCT:48156001", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5174625", "l": "Neutrophils | Synovial fluid | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "ic": "58.697068671355382", "identifiers": [{"i": "CL:0000447", "l": "carbohydrate secreting cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5154484", "l": "Basophils | Vitreous fluid | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2322975", "l": "Radial astrocyte", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1182604", "l": "Stem cell of epidermis", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0882831", "l": "Cells.CD3+CD26+", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C4733685", "l": "Autologous HER2-specific/EGFRt-expressing CD4/CD8-positive CAR T-cells", "d": []}, {"i": "NCIT:C156156", "l": "Autologous HER2-specific/EGFRt-expressing CD4/CD8-positive CAR T-cells", "d": ["A preparation of CD4+ and CD8+ autologous T-lymphocytes transduced with a lentiviral vector expressing a human epidermal growth factor receptor type 2 (HER2; EGFR2; ErbB2)-specific chimeric antigen receptor (CAR) coupled to a truncated form of the human epidermal growth factor receptor (EGFRt), with potential immunostimulating and antineoplastic activities. Upon intravenous administration, the autologous HER2-specific/EGFRt-expressing CD4/CD8-positive CAR T-cells are directed to and induce selective toxicity in HER2-expressing tumor cells. Devoid of both ligand binding domains and tyrosine kinase activity, the expressed EGFRt both facilitates in vivo detection of the administered, transduced T-cells and can promote elimination of these cells through an anti-EGFR antibody-induced antibody-dependent cellular cytotoxicity (ADCC) response. HER2, a receptor tyrosine kinase (RTK) overexpressed by a variety of tumor cell types, belongs to the EGFR superfamily and plays a key role in tumor cell proliferation."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0229535", "l": "Pituitary cell", "d": []}, {"i": "SNOMEDCT:82406005", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5170959", "l": "Leukocytes other | Vitreous fluid | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1179416", "l": "Endothelial cell of venous sinus of red pulp of spleen", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4699468", "l": "Light-chain negative plasma cells", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5216309", "l": "Platelets|NCnc|Pt|Plas", "d": []}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "CL:0002469", "l": "MHC-II-negative classical monocyte", "d": ["Gr1-high monocyte that lacks MHC-II receptor complex."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4733878", "l": "Keratinocytes (Human)", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0882860", "l": "Cells.CD4+CD25+", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5707273", "l": "Anti-CD19-CAR CMV-specific T-lymphocytes", "d": []}, {"i": "NCIT:C187649", "l": "Anti-CD19-CAR CMV-specific T-lymphocytes", "d": ["A preparation of human cytomegalovirus (CMV)-specific T-lymphocytes that have been engineered to express a chimeric antigen receptor (CAR) specific for the human tumor associated antigen (TAA) CD19, with potential immunostimulating and antineoplastic activities. Upon administration, anti-CD19-CAR CMV-specific T-lymphocytes recognize, bind to, and induce selective toxicity in CD19-expressing tumor cells. CD19 is a B-cell specific cell surface antigen overexpressed in B-cell lineage malignancies. The anti-CD19-CAR CMV-specific T-lymphocytes may potentially be expanded in vivo through CMV vaccination."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0000249", "l": "hatching gland cell", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1179135", "l": "Type IV taste bud cell", "d": []}, {"i": "NCIT:C13185", "l": "Taste Bud Basal Cell", "d": ["A small, round cell found in the lower part of the epidermis of the taste bud. It differentiates into a new receptor cell and renewed about every 10 days."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:2000055", "l": "liver dendritic cell", "d": ["Any dendritic cell that is part of a liver."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157355", "l": "CD19+CD27+IgD-IgM+ cells | Blood | Cell markers", "d": []}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "CL:2000056", "l": "Meynert cell", "d": ["Any pyramidal cell that is part of a regional part of cerebral cortex."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0007016", "l": "adaxial cell", "d": ["Muscle precursor cell that is adjacent to the notochord and part of the presomitic mesoderm."]}]}
{"type": "biolink:Cell", "ic": "52.62461716281927", "identifiers": [{"i": "CL:0008004", "l": "somatic muscle cell", "d": ["A muscle cell that is part of some somatic muscle."]}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "CL:1001216", "l": "interlobulary artery endothelial cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2325226", "l": "Transitional myocyte of interventricular septum", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2335260", "l": "Fibroblast of tunica adventitia of artery", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:4030042", "l": "glandular endometrial ciliated epithelial cell", "d": ["A ciliated cell of the endometrial glandular epithelium."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C4085987", "l": "Anti-mesothelin CAR Vector-transduced Autologous T-lymphocytes", "d": []}, {"i": "NCIT:C124650", "l": "Anti-mesothelin CAR Vector-transduced Autologous T-lymphocytes", "d": ["Genetically modified, autologous T-lymphocytes transduced with a retroviral vector encoding a chimeric antigen receptor (CAR) consisting of an anti-human tumor-associated antigen (TAA) mesothelin single chain variable fragment (scFv), the intracellular CD3 zeta T-cell receptor domain and the 4-1BB (cd137) costimulatory domain, with potential immunomodulating and antineoplastic activities. After isolation, transduction, expansion in culture, and reintroduction into the patient, the anti-mesothelin CAR vector-transduced autologous T-lymphocytes specifically target and kill mesothelin-expressing tumor cells. Mesothelin, a cell surface glycoprotein involved in cell adhesion, is overexpressed in a variety of cancer cell types."]}]}
{"type": "biolink:Cell", "ic": "90.82444074280258", "identifiers": [{"i": "CL:0002461", "l": "CD103-positive dendritic cell", "d": ["A conventional dendritic cell that is CD103-positive. This cell type is usually found in non-lymphoid tissue."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2339058", "l": "Myocyte of atrial branch of anterior internodal tract", "d": []}]}
{"type": "biolink:Cell", "ic": "58.058027480038866", "identifiers": [{"i": "UMLS:C1947950", "l": "Embryonic Cell", "d": []}, {"i": "NCIT:C13054", "l": "Embryonic Cell", "d": ["A cell formed in the initial stages of embryonic development, after zygote formation."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5181452", "l": "S-phase cells | XXX | Molecular pathology", "d": []}]}
{"type": "biolink:Cell", "ic": "62.704640979746422", "identifiers": [{"i": "CL:0000207", "l": "olfactory receptor cell", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1517642", "l": "KA42", "d": []}, {"i": "NCIT:C20272", "l": "KA42", "d": ["Provider: Karolinska Institute, Stockholm, Sweden. No information from provider. This cell line meets the criteria for the use of human embryonic stem cells by federally funded researchers."]}]}
{"type": "biolink:Cell", "ic": "92.728541327098611", "identifiers": [{"i": "CL:1001106", "l": "kidney loop of Henle thick ascending limb epithelial cell", "d": ["An epithelial cell that is part of some loop of Henle thick ascending limb. It is known in some mammalian species that this cell may express the Na+-K+-2Cl− cotransporter (NKCC2) apically."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1181163", "l": "Set of central neuroglial cells", "d": []}]}
{"type": "biolink:Cell", "ic": "84.128890093485552", "identifiers": [{"i": "CL:0002167", "l": "olfactory epithelial cell", "d": ["A specialized cell involved in sensory perception of smell."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C0029330", "l": "Orthochromic normoblast (cell)", "d": []}, {"i": "NCIT:C13132", "l": "Orthochromatic Erythroblast", "d": ["A cell derived from a polychromatophilic erythroblast in bone marrow. It has a dense nucleus and its cytoplasm is approaching the color of a mature erythrocyte. It differentiates into a reticulocyte when it extrudes its nucleus."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5163727", "l": "Erythrocytes | Synovial fluid | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "CL:1000222", "l": "stomach neuroendocrine cell", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5237723", "l": "Engineered Mobilized Peripheral Blood-derived Donor Graft OGFT-001", "d": []}, {"i": "NCIT:C166136", "l": "Engineered Mobilized Peripheral Blood-derived Donor Graft OGFT-001", "d": ["An engineered donor graft derived from mobilized peripheral blood stem cells (PBSCs) that can potentially be used for immune reconstitution purposes. Upon administration of the engineered mobilized peripheral blood-derived donor graft OGFT-001 after an allogeneic hematopoietic cell transplantation, these cells provide hematopoietic cell recovery."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C4763629", "l": "Valproic Acid-Expanded Umbilical Cord Blood-derived CD34-positive Cells", "d": []}, {"i": "NCIT:C157453", "l": "Valproic Acid-Expanded Umbilical Cord Blood-derived CD34-positive Cells", "d": ["A preparation of umbilical cord blood (UCB)-derived CD34-positive cells treated with valproic acid (VPA) with potential use in hematopoietic stem cell transplant (HSCT). Upon positive immunomagnetic selection of CD34-positive cells from UCB units, CD34-positive cells are expanded in culture with stem cell factor (SCF), FMS-like tyrosine kinase 3 ligand (Flt3L), thrombopoietin (TPO), and interleukin-3 (IL-3), treated with VPA, and infused into the patient. VPA, a histone deacetylase inhibitor (HDACi), may induce epigenetic changes in UCB hematopoietic stem cells (HSCs), resulting in expansion of CD34-positive cells enriched in short term (ST), intermediate term (IT), and long term (LT) marrow repopulating cells (RCs), which are capable of sustained hematopoietic engraftment following transplantation. Further, VPA-expanded UCB stem cells may shorten the time to neutrophil and platelet recovery and maintain long-term hematopoietic and immune reconstitution compared to untreated UCB grafts."]}]}
{"type": "biolink:Cell", "ic": "83.023198044254755", "identifiers": [{"i": "CL:0002096", "l": "internodal tract myocyte", "d": ["A specialised myocyte that lies between the sinoatrial node and the atrioventricular node and is involved in the conduction of electrical signals."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1516898", "l": "Eosinophil Precursor Cell", "d": []}, {"i": "NCIT:C41177", "l": "Eosinophil Precursor Cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2331714", "l": "Regular interventricular cardiac myocyte", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4246477", "l": "Mesomesenchymal cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5177775", "l": "Polyclonal plasma cells | Bone marrow | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2335794", "l": "Myocyte of atrial septal branch of anterior internodal tract", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1179476", "l": "Mucous cell of gastric gland", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C2827682", "l": "Autologous TGFbeta-Resistant HER2/EBV-Specific Cytotoxic T Lymphocytes", "d": []}, {"i": "NCIT:C85459", "l": "Autologous TGFbeta-Resistant HER2/EBV-Specific Cytotoxic T Lymphocytes", "d": ["A preparation of transforming growth factor-beta (TGF-beta)-resistant Epstein-Barr virus (EBV)-specific cytotoxic T-lymphocytes (CTLs) directed to EBV through their native receptor and HER2 through a retrovirally transduced HER2 chimeric antigen receptor (CAR) with potential antineoplastic activity. Autologous EBV-specific CTLs are produced by exposing autologous CTLs to \"stimulator\" autologous EBV-transformed lymphoblastoid cell lines (EBV-LCLs). Subsequently, autologous EBV-specific CTLs are transduced with retroviral vectors expressing the mutant type II TGF-beta dominant-negative receptor (DNR), which blocks signaling by all three TGF-beta isoforms, and the HER2 CAR. After transduction, transgenic EBV-CTLs are expanded on EBV-LCLs. Upon administration, autologous HER2 chimeric receptor/TGFbeta dominant negative receptor-expressing EBV-specific cytotoxic T lymphocytes may bind to HER2-expressing tumors cells, which may result in CTL-mediated cell lysis and inhibition of tumor cell proliferation. Tumor-expressed TGF-beta inhibits T lymphocyte activation and expansion."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5216228", "l": "Leukocytes other|NCnc|Pt|Plr fld", "d": []}]}
{"type": "biolink:Cell", "ic": "86.236661114203869", "identifiers": [{"i": "UMLS:C1513950", "l": "Neoplastic Elongated Glial Cell", "d": []}, {"i": "NCIT:C37144", "l": "Neoplastic Elongated Glial Cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5187191", "l": "Platelets^BPU", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5448071", "l": "Tumor-Infiltrating T Helper 17 Cell", "d": []}, {"i": "NCIT:C176757", "l": "Tumor-Infiltrating T Helper 17 Cell", "d": ["A T helper 17 cell that has migrated into a tumor."]}]}
{"type": "biolink:Cell", "ic": "74.240948556675605", "identifiers": [{"i": "CL:0002496", "l": "intraepithelial lymphocyte", "d": ["A T cell that is located in the intestinal epithelium and is capable of a mucosal immune response."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002514", "l": "Vgamma5-negative CD8alpha alpha positive gamma-delta intraepithelial T cell", "d": ["A CD8alpha alpha positive gamma-delta intraepithelial T cell that does not express a TCR partially encoded by the Vgamma5 gene segment."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5216234", "l": "Leukocytes|NCnc|Pt|CSF", "d": []}]}
{"type": "biolink:Cell", "ic": "80.869303025598512", "identifiers": [{"i": "CL:0002504", "l": "enteric smooth muscle cell", "d": ["A smooth muscle cell of the intestine."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0882784", "l": "Cell positive for CD11C antigen", "d": []}, {"i": "SNOMEDCT:116750001", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C3495384", "l": "A16 dopamine cells", "d": []}]}
{"type": "biolink:Cell", "ic": "80.17194633000733", "identifiers": [{"i": "CL:0001203", "l": "CD8-positive, alpha-beta memory T cell, CD45RO-positive", "d": ["A CD8-positive, alpha-beta T cell with memory phenotype indicated by being CD45RO and CD127-positive. This cell type is also described as being CD25-negative, CD44-high, and CD122-high."]}]}
{"type": "biolink:Cell", "ic": "76.659841615658792", "identifiers": [{"i": "CL:1000494", "l": "nephron tubule epithelial cell", "d": ["An epithelial cell that is part of a nephron tubule."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1183932", "l": "Luminal cell of prostatic acinus", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157346", "l": "CD19 cells | Bone marrow | Cell markers", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2950600", "l": "Type D cell of jejunum", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4510882", "l": "Blast cell positive for CD36 antigen", "d": []}, {"i": "SNOMEDCT:725109000", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0011016", "l": "flagellated sperm cell", "d": ["A motile sperm cell that contains a slender threadlike microscopic appendage that enables motion."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0011100", "l": "galanergic neuron", "d": ["Neuron that secretes the neurotransmitter galanin."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5163771", "l": "Erythroid cells | Blood or Marrow | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:4033026", "l": "lung perichondrial fibroblast", "d": ["A perichondrial fibroblast that is part of the lung."]}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "UMLS:C1517811", "l": "Leukemic Plasma Cell", "d": []}, {"i": "NCIT:C41071", "l": "Leukemic Plasma Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002474", "l": "lymphoid MHC-II-negative classical monocyte", "d": ["A MHC-II-negative classical monocyte located in lymphoid tissue that is F4/80-positive, CD11c-negative, and CD11b-high."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C3641004", "l": "Apoptotic Autologous Tumor Cells-pulsed Alpha-type-1 Polarized Dendritic Cells", "d": []}, {"i": "NCIT:C102978", "l": "Apoptotic Autologous Tumor Cells-pulsed Alpha-type-1 Polarized Dendritic Cells", "d": ["A cell based cancer vaccine composed of mature polarized dendritic cells (DCs) and pulsed with apoptotic autologous tumor cells that has potential immunostimulating and antineoplatic activities. Dendritic cells (DCs) were treated with interleukin-1beta, tumor necrosis factor alpha, interferon-alpha (IFN-a), IFN-gamma and polyinosinic:polycytidylic acid (p-I:C) to produce mature alpha type-1 polarized DCs (alphaDC1) that are capable of producing high levels of interleukin-12p70 (IL-12p70). The alphaDC1 are subsequently pulsed with apoptotic autologous tumor cells. Upon administration, these DCs are able to induce a potent cytotoxic T lymphocyte (CTL) response against tumor associated antigens (TAAs), resulting in tumor cell lysis and inhibition of tumor cell growth. Apoptotic tumor cells contain an array of TAAs."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0596698", "l": "heterokaryon", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4518150", "l": "Population of all spermatozoa with bent midpiece in portion of fluid", "d": []}, {"i": "SNOMEDCT:725239001", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1440302", "l": "Cells.CD38+CD56+", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C4764235", "l": "Autologous Anti-MUC1*-CAR-4-1BB-CD3zeta-expressing T-lymphocytes", "d": []}, {"i": "NCIT:C158439", "l": "Autologous Anti-MUC1*-CAR-4-1BB-CD3zeta-expressing T-lymphocytes", "d": ["A preparation of autologous T-lymphocytes transduced with a lentiviral vector encoding a human CD8 alpha leader sequence, a humanized MNC2-single chain variable fragment (scFv) targeting the extracellular domain of the cleaved form of mucin-1 (MUC-1), known as MUC1*, portions of human CD8 hinge and transmembrane domains, and human 4-1BB and human CD3-zeta costimulatory domains, with potential antineoplastic and immunostimulating activities. Upon re-introduction into the patient, the autologous anti-MUC1*-CAR-4-1BB-CD3zeta-expressing T-lymphocytes specifically recognize and induce selective toxicity in MUC1*-expressing tumor cells. MUC1* is a post-translationally modified form of MUC1, a single pass type I transmembrane protein that is normally expressed in the glandular or luminal epithelial cells of the esophagus, stomach, duodenum, pancreas, uterus, prostate, and lungs, and may be aberrantly expressed in certain tumor types. MUC1* is a growth factor that is activated by ligand-induced dimerization of its extracellular domain, which may stimulate mitogen-activated protein kinase (MAP kinase, MAPK) signaling and promote tumor cell growth. MUC1* is frequently expressed in certain cancer types, with increased expression noted in higher grade lesions and tumor cells resistant to certain chemotherapies."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002545", "l": "thoracic aorta endothelial cell", "d": ["An endothelial cell that is part of the thoracic endothelium."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0314583", "l": "Colony-forming unit of basophilic lineage", "d": []}, {"i": "SNOMEDCT:445114000", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157516", "l": "CD3-CD16+ cells | Body fluid | Cell markers", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0546508", "l": "P.B. lymphoblast", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002104", "l": "IgG-negative double negative memory B cell", "d": ["An IgG-negative double negative memory B cell is a double negative memory B cell with the phenotype IgG-negative, IgD-negative, and CD27-negative."]}]}
{"type": "biolink:Cell", "ic": "78.435418415656045", "identifiers": [{"i": "UMLS:C1522639", "l": "Leukocyte (WBC) (MMHCC)", "d": []}, {"i": "NCIT:C22570", "l": "Mouse Leukocyte", "d": []}]}
{"type": "biolink:Cell", "ic": "82.532694649739099", "identifiers": [{"i": "CL:1001318", "l": "renal interstitial pericyte", "d": ["A pericyte cell located in the kidney interstitium."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0597690", "l": "WI38 cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C3178740", "l": "Be1 Cells", "d": []}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "UMLS:C1709771", "l": "Pulmonary Neuroendocrine Cell", "d": []}, {"i": "NCIT:C45572", "l": "Pulmonary Neuroendocrine Cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157353", "l": "CD19+CD27+IgD+IgM+ cells | Blood | Cell markers", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C4329370", "l": "Autologous ICASP9-CD19-expressing T-Lymphocytes", "d": []}, {"i": "NCIT:C131214", "l": "Autologous iCasp9-deltaNGFR-CD19CAR-expressing T Cells", "d": ["A preparation of autologous T-lymphocytes that are transduced with a retroviral vector encoding a chimeric antigen receptor (CAR) specific for the CD19 antigen, the suicide gene, inducible human caspase 9 (iCasp9 or iC9), and a truncated low-affinity nerve growth factor receptor (deltaNGFR), with potential immunomodulating and antineoplastic activities. The iCasp9 construct consists of the entire coding sequence for the human FK506-drug binding protein (FKBP12) with an F36V mutation (FKBP12-F36V) that is linked to the gene encoding human caspase 9, which is deleted of its endogenous caspase activation and recruitment domains. Upon intravenous administration, autologous iCasp9-deltaNGFR-CD19CAR-expressing T cells are selectively toxic to CD19-expressing tumor cells. If the administered T-cells lead to unacceptable side effects, the chemical homodimerizer AP1903 can be administered, which binds to the FKBP12-F36V drug binding domain, activates caspase 9, and results in apoptosis of the administered CAR19 T-cells. The CD19 antigen is a B-cell specific cell surface antigen expressed in all B-cell lineage malignancies. Prior to administration, deltaNGFR, is used to select the CAR19-transduced T-cells for further enrichment by flow cytometry using an anti-NGFR antibody."]}]}
{"type": "biolink:Cell", "ic": "60.052555154946383", "identifiers": [{"i": "UMLS:C1514081", "l": "Neoplastic Serous Epithelial Cell", "d": []}, {"i": "NCIT:C37114", "l": "Neoplastic Serous Epithelial Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "87.120474278337809", "identifiers": [{"i": "UMLS:C0225828", "l": "Myocytes, Cardiac", "d": []}, {"i": "NCIT:C13002", "l": "Cardiomyocyte", "d": ["A muscle cell in heart tissue (myocardium)."]}, {"i": "MESH:D032383", "l": "Myocytes, Cardiac", "d": []}, {"i": "SNOMEDCT:86441007", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1440379", "l": "Cells.cytoplasmic CD79", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0007018", "l": "epidermal ciliary cell", "d": ["Ciliated cell of the embryonic epidermis and functions in embryonic movements."]}]}
{"type": "biolink:Cell", "ic": "70.365551207689407", "identifiers": [{"i": "CL:0000166", "l": "chromaffin cell", "d": ["A cell that stores epinephrine secretory vesicles. During times of stress, the nervous system signals the vesicles to secrete their hormonal content. Their name derives from their ability to stain a brownish color with chromic salts. Characteristically, they are located in the adrenal medulla and paraganglia of the sympathetic nervous system."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5177620", "l": "Platelets | Dialysis fluid | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157554", "l": "CD4+CD45RO+ cells | Tissue and Smears | Cell markers", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1515267", "l": "Tendinocyte", "d": []}, {"i": "NCIT:C33747", "l": "Tendinocyte", "d": ["An elongated cell with invisible cytoplasm and flattened, poorly-stained, nucleus. It is found in the tendon and is positioned in a very regular pattern of rows between parallel bundles of collagen fibers. It makes up the fibers and ground substance of the tendon."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2324017", "l": "H II cell of retina", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C4086005", "l": "Autologous Cytotoxic T-lymphocytes Induced with MUC1 Gene-transfected Dendritic Cells", "d": []}, {"i": "NCIT:C124997", "l": "Autologous Cytotoxic T-lymphocytes Induced with MUC1 Gene-transfected Dendritic Cells", "d": ["A preparation of autologous cytotoxic T-lymphocytes (CTL), specifically reactive to the tumor-associated antigen (TAA) mucin-1 (MUC1), with potential antineoplastic activity. Peripheral blood mononuclear cells (PBMCs) are collected from the patient with MUC1-positive tumors and are exposed ex vivo to dendritic cells (DCs) transfected with a replication-deficient adenovirus encoding MUC1 to generate MUC1-specific CTLs, which are subsequently expanded in vitro. Upon re-infusion of autologous CTLs induced with MUC1 gene-transfected DCs to the patient, the CTLs target and lyse the MUC1-expressing tumor cells. This inhibits tumor cell proliferation. MUC1 is expressed by a variety of tumor cell types."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C4764289", "l": "Autologous Anti-CD19 CAR-expressing T-lymphocytes CLIC-1901", "d": []}, {"i": "NCIT:C158604", "l": "Autologous Anti-CD19 CAR-expressing T-lymphocytes CLIC-1901", "d": ["A preparation of autologous T-lymphocytes that have been genetically modified to express a chimeric antigen receptor (CAR) that targets the human tumor associated antigen (TAA) CD19, with potential immunostimulating and antineoplastic activities. Upon administration, autologous anti-CD19 CAR-expressing T-lymphocytes CLIC-1901 bind to and induce selective toxicity against CD19-expressing tumor cells. The CD19 antigen is a B-cell-specific cell surface antigen expressed in all B-cell lineage malignancies."]}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "UMLS:C1709223", "l": "Nevoid Polygonal Cell", "d": []}, {"i": "NCIT:C54077", "l": "Nevoid Polygonal Cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C3495989", "l": "A3 catecholamine cells", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C4724868", "l": "Autologous EGFRt/BCMA-41BBz-targeted CAR T Cells", "d": []}, {"i": "NCIT:C148168", "l": "Autologous EGFRt/BCMA-41BBz-targeted CAR T Cells", "d": ["A preparation of autologous T-lymphocytes transduced with a retroviral vector expressing a chimeric antigen receptor (CAR) specific for the tumor-associated antigen (TAA) human B-cell maturation antigen (BCMA; tumor necrosis factor receptor superfamily member 17; TNFRSF17) fused to the co-stimulatory domain of 4-1BB (CD137) and the CD3-zeta (CD3z) T-cell signaling domain, and a truncated form of the human epidermal growth factor receptor (EGFRt), with potential immunostimulating and antineoplastic activities. Upon intravenous administration, autologous EGFRt/BCMA-41BBz-targeted CAR T cells are directed to, and induce selective toxicity in, BCMA-expressing tumor cells. Devoid of both ligand-binding domains and tyrosine kinase activity, the expressed EGFRt facilitates in vivo detection of the administered, transduced T-cells and, if the administered T-cells cause unacceptable side effects, can promote elimination of those cells through a cetuximab-induced antibody-dependent cellular cytotoxicity (ADCC) response. The 4-1BB costimulatory signaling domain enhances both proliferation of T-cells and antitumor activity. BCMA, a receptor for both a proliferation-inducing ligand (APRIL) and B-cell activating factor (BAFF), is a member of the tumor necrosis factor receptor superfamily (TNFRSF) and plays a key role in plasma cell survival. BCMA is found on the surfaces of plasma cells and is overexpressed on malignant plasma cells."]}]}
{"type": "biolink:Cell", "ic": "75.105493098994543", "identifiers": [{"i": "CL:4023049", "l": "L5 intratelencephalic projecting glutamatergic neuron of the primary motor cortex", "d": ["An intratelencephalic-projecting glutamatergic neuron with a soma found in L5 of the primary motor cortex."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5446937", "l": "Autologous Anti-NY-ESO-1 TCR/CD8alpha-expressing T-cells GSK3901961", "d": []}, {"i": "NCIT:C176040", "l": "Autologous Anti-NY-ESO-1 TCR/CD8alpha-expressing T-cells GSK3901961", "d": ["A preparation of human autologous T-lymphocytes that are genetically modified to express a T-cell receptor (TCR) specific for the human cancer-testis antigen NY-ESO-1 and the CD8alpha co-receptor, with potential immunostimulating and antineoplastic activities. Upon leukapheresis, isolation, transduction, expansion ex vivo, and reintroduction into the patient, the autologous anti-NY-ESO-1 TCR/CD8alpha-expressing T-cells GSK3901961 recognize and bind to NY-ESO-1-overexpressing tumor cells. This may result in a specific cytotoxic T-lymphocyte (CTL)-mediated killing of NY-ESO-1-positive tumor cells. NY-ESO-1, a tumor-associated antigen (TAA), is found in normal testis and on the surface of various tumor cell types. Co-expression of CD8alpha may broaden the immune response against tumors and increase antitumor activity by converting CD4+ helper T-cells into CD8+ cytotoxic T-cells."]}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "UMLS:C3899623", "l": "Circulating Stem Cell", "d": []}, {"i": "NCIT:C115116", "l": "Circulating Stem Cell", "d": ["A primitive cell found in the peripheral blood that has the ability either to divide and renew the primitive cell pool or to differentiate into various specialized cell types."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0229631", "l": "Siderocyte", "d": []}, {"i": "SNOMEDCT:61837008", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0003046", "l": "M13 retinal ganglion cell", "d": ["A bistratifed retinal ganglion cell that has small, symmetric dendritic fields that terminate in S2 and S4."]}]}
{"type": "biolink:Cell", "ic": "89.347505587204751", "identifiers": [{"i": "UMLS:C0225698", "l": "Alveolar Epithelial Cells", "d": []}, {"i": "NCIT:C32053", "l": "Alveolar Cell", "d": ["A cell found in the walls of the pulmonary alveoli; the term is limited to alveolar epithelial cells (type I and type II alveolar cells)."]}, {"i": "MESH:D056809", "l": "Alveolar Epithelial Cells", "d": []}, {"i": "SNOMEDCT:47438009", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5170922", "l": "Leukocytes | Bronchial | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5555583", "l": "CXCR4-modified Anti-BCMA CAR T Cells", "d": []}, {"i": "NCIT:C179284", "l": "CXCR4-modified Anti-BCMA CAR T Cells", "d": ["A preparation of T-lymphocytes that have been genetically engineered to express a chimeric antigen receptor (CAR) targeting the tumor-associated antigen (TAA) B-cell maturation antigen (BCMA; TNFRSF17) with modification of the C-X-C chemokine receptor type 4 (CXCR4), with potential immunomodulating and antineoplastic activities. Upon administration, the CXCR4-modified anti-BCMA CAR T cells target and bind to tumor cells expressing BCMA and induce selective cytotoxicity in those tumor cells. The modification of the stromal-cell derived factor-1 (SDF-1 or CXCL12) receptor CXCR4 may improve the penetration of CAR T cells into the tumor microenvironment (TME). BCMA, a receptor for both a proliferation-inducing ligand (APRIL) and B-cell activating factor (BAFF), is a member of the tumor necrosis factor receptor superfamily (TNFRSF). BCMA is found on the surfaces of plasma cells, is overexpressed on malignant plasma cells and plays a key role in plasma cell proliferation and survival."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0333847", "l": "Mott plasma cell", "d": []}, {"i": "SNOMEDCT:83718009", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1266873", "l": "Bladder epithelial cell", "d": []}, {"i": "SNOMEDCT:115596003", "d": []}]}
{"type": "biolink:Cell", "ic": "90.82444074280258", "identifiers": [{"i": "CL:0000709", "l": "R8 photoreceptor cell", "d": []}]}
{"type": "biolink:Cell", "ic": "90.82444074280258", "identifiers": [{"i": "CL:0000773", "l": "eosinophilic metamyelocyte", "d": ["A eosinophil precursor in the granulocytic series, being a cell intermediate in development between a eosinophilic myelocyte and a band form eosinophil. The nucleus becomes indented where the indentation is smaller than half the distance to the farthest nuclear margin; chromatin becomes coarse and clumped; specific granules predominate while primary granules are rare. Markers are integrin alpha-M-positive, fucosyltransferase FUT4-positive, low affinity immunoglobulin gamma Fc region receptor III-positive, CD33-positive, CD24-positive and aminopeptidase N-negative."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:1001213", "l": "arcuate artery endothelial cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1979232", "l": "Blasts.CD34+CD117+", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0009054", "l": "microfold cell of epithelium proper of anorectum", "d": ["A microfold cell (M cell) that is part of the anorectum."]}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "UMLS:C1708910", "l": "Malignant Smooth Muscle Cell with Granular Cytoplasmic Change", "d": []}, {"i": "NCIT:C49128", "l": "Malignant Smooth Muscle Cell with Granular Cytoplasmic Change", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1510960", "l": "Atypical Metaplastic Apocrine Cell", "d": []}, {"i": "NCIT:C36909", "l": "Atypical Metaplastic Apocrine Cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2327656", "l": "Basal cell of epithelium of terminal bronchiole", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5170950", "l": "Leukocytes other | Blood | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2328553", "l": "Transitional myocyte of sinuatrial node", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002363", "l": "keratocyte", "d": ["A keratocyte is a specialized fibroblast residing in the cornea stroma that has a flattened, dendritic cell located between the lamellae with a large flattened nucleus and lengthy processes which communicate with neighboring cells. This corneal layer, representing about 85-90% of corneal thickness, is built up from highly regular collagenous lamellae and extracellular matrix components. Keratocytes play the major role in keeping it transparent, healing its wounds, and synthesizing its components. This cell type secretes collagen I, V, VI, and keratin sulfate."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5151348", "l": "Abnormal lymphocytes | Blood | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "ic": "81.247621244257502", "identifiers": [{"i": "CL:0000752", "l": "cone retinal bipolar cell", "d": ["A bipolar neuron found in the retina and having connections with cone photoreceptor cells and neurons in the inner plexiform layer."]}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "UMLS:C1518367", "l": "Non-Keratinizing Malignant Large Squamous Cell", "d": []}, {"i": "NCIT:C36793", "l": "Non-Keratinizing Malignant Large Squamous Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5667586", "l": "Autologous Desmoglein-3 Chimeric Autoantibody Receptor T-cells DSG3-CAART", "d": []}, {"i": "NCIT:C182441", "l": "Autologous Desmoglein-3 Chimeric Autoantibody Receptor T-cells DSG3-CAART", "d": ["A preparation of autologous T-lymphocytes that have been engineered to express a chimeric autoantibody receptor (CAAR) containing the autoantigen desmoglein-3 (desmoglein 3; DSG3) that is fused to the co-stimulatory domain of 4-1BB (CD137) and the T-cell receptor signaling domain of CD3zeta (CD3z), with potential immunomodulatory activity. Upon administration, the autologous DSG3 chimeric autoantibody receptor T-cells (CAART) DSG3-CAART specifically recognize and induce selective toxicity in aberrant B-cells expressing DSG3 autoantibodies. This inhibits the production of DSG3 autoantibodies. DSG3 is a protein expressed in desmosomes that plays an important role in cell adhesion. DSG3 autoantibodies are produced and expressed by aberrant B-cells in the autoimmune disease mucosal-dominant pemphigus vulgaris."]}]}
{"type": "biolink:Cell", "ic": "86.236661114203869", "identifiers": [{"i": "UMLS:C1518369", "l": "Non-Keratinizing Malignant Squamous Cell", "d": []}, {"i": "NCIT:C36792", "l": "Non-Keratinizing Malignant Squamous Cell", "d": ["A malignant squamous cell that does not produce keratin."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5418069", "l": "Multi-antigen-directed Autologous T-cells NEXI-002", "d": []}, {"i": "NCIT:C174128", "l": "Multi-antigen-directed Autologous T-cells NEXI-002", "d": ["A preparation of autologous T-cells targeting several multiple myeloma (MM)-associated antigens, with potential immunomodulating and antineoplastic activities. Peripheral blood mononuclear cells (PBMC) from the patient are collected and ex vivo exposed to nanoparticles that mimic antigen-presenting cells (APCs) loaded with multiple MM-associated antigens, including Wilms' tumor 1 (WT1), CD138 (syndecan-1; SDC1), cancer-testis antigen NY-ESO-1 and CS1 (CD319; CRACC; SLAMF7), and are further enriched and expanded ex-vivo before being re-introduced into the patient. Upon administration, the multi-antigen-directed autologous T-cells NEXI-002 are re-introduced into the patient, where they target and kill tumor cells expressing these antigens."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1440340", "l": "CD62P Cells", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C4330828", "l": "Non-Fucosylated Umbilical Cord Blood Regulatory T-cells", "d": []}, {"i": "NCIT:C131536", "l": "Non-Fucosylated Umbilical Cord Blood Regulatory T-cells", "d": ["A preparation of non-fucosylated regulatory T-lymphocytes (Tregs) allogeneically derived from umbilical cord blood (UCB), with potential immunomodulating activity. Tregs are essential in maintaining immunologic homeostasis, preventing autoimmunity, through the suppression of self-reactive T-cells, and they may induce tolerance to allogeneic organ transplants, including hematopoetic stem cell transplants (HSCTs). Administration of the non-fucosylated UCB Tregs upon HSCT may prevent or reduce graft-versus host disease (GVHD)."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C3896829", "l": "axicabtagene ciloleucel", "d": []}, {"i": "MESH:C000629083", "l": "axicabtagene ciloleucel", "d": []}, {"i": "SNOMEDCT:764088001", "d": []}, {"i": "SNOMEDCT:764116009", "d": []}]}
{"type": "biolink:Cell", "ic": "88.140761698499901", "identifiers": [{"i": "CL:1000271", "l": "lung ciliated cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2330431", "l": "Goblet cell of epithelium proper of duodenum", "d": []}]}
{"type": "biolink:Cell", "ic": "84.75972595860604", "identifiers": [{"i": "CL:0002252", "l": "epithelial cell of esophagus", "d": ["An epithelial cell of the esophagus."]}]}
{"type": "biolink:Cell", "ic": "73.597844352697123", "identifiers": [{"i": "CL:0005009", "l": "renal principal cell", "d": ["A cuboidal epithelial cell of the kidney which regulates sodium and potassium balance. The activity of sodium and potassium channels on the apical membrane of the cell is regulated by aldosterone and vasopressin. In mammals this cell type is located in the renal collecting duct system."]}]}
{"type": "biolink:Cell", "ic": "90.82444074280258", "identifiers": [{"i": "CL:1000682", "l": "kidney medulla interstitial cell", "d": []}]}
{"type": "biolink:Cell", "ic": "76.857431420584163", "identifiers": [{"i": "UMLS:C1513023", "l": "Mature Cytotoxic T-Lymphocyte", "d": []}, {"i": "NCIT:C38324", "l": "Mature Cytotoxic T-Lymphocyte", "d": ["A peripheral white blood cell that produces cytokines and kills infected target cells. It has a CD8 marker on its surface and has been activated by contact with MHC class I receptors and cytokines."]}]}
{"type": "biolink:Cell", "ic": "67.582339958156282", "identifiers": [{"i": "UMLS:C0524457", "l": "Structure of endometrial glandular cell", "d": []}, {"i": "NCIT:C32515", "l": "Endometrial Glandular Cell", "d": ["An epithelial cell lining the endometrial cavity, located in the uterus. These cells proliferate and respond to the cyclic variations of estrogen and progesterone.  They synthesize or transport and secrete substances essential for survival and development of the embryo/fetus and associated extraembryonic membranes."]}, {"i": "SNOMEDCT:91768008", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C3176907", "l": "Cells.cytoplasmic CD79a", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002360", "l": "AGM hematopoietic stem cell", "d": ["A hematopoietic stem cell from the aorta-gonad-mesonephros region of the developing embryo. First seen at E10.5 in mouse embryos. May give rise to fetal liver HSC."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5238225", "l": "Chlorotoxin (EQ)-CD28-CD3zeta-CD19t-expressing CAR T-lymphocytes", "d": []}, {"i": "NCIT:C167056", "l": "Chlorotoxin (EQ)-CD28-CD3zeta-CD19t-expressing CAR T-lymphocytes", "d": ["A preparation of genetically modified T-lymphocytes transduced with a lentiviral vector expressing a chimeric antigen receptor (CAR) comprised of a CD28 co-stimulatory signaling domain fused to the zeta chain of the TCR/CD3 complex (CD3zeta), a truncated form of CD19 (CD19t), an immunoglobulin (Ig) G4-Fc (EQ) spacer, and a peptide derived from chlorotoxin (CLTX), with potential imaging and antineoplastic activities. Upon administration, chlorotoxin (EQ)-CD28-CD3zeta-CD19t-expressing CAR T-lymphocytes are re-directed to specific tumor cells in the brain inducing selective toxicity in these tumor cells. CLTX, a 36-amino acid peptide found in the venom of the deathstalker scorpion (Leiurus quinquestriatus) and a chloride channel blocker, preferentially binds to glioma (and other neuroectodermal origin) cells via membrane bound forms of the endopeptidase matrix metalloproteinase-2 (MMP-2). This may direct the T-lymphocytes to and induce selective toxicity in MMP-2-expressing tumor cells. Additionally, binding to MMP-2 on glioma cells may both interfere with transmembrane chloride exchange and inhibit proteolytic extracellular matrix remodeling by MMP-2, which may further limit the spread of these tumor cells. MMP-2 is specifically upregulated in gliomas and related cancers, but is not normally expressed in brain. The CD28 co-stimulatory molecule signaling domain enhances activation and signaling; its inclusion may increase proliferation of T-cells and antitumor activity compared to the inclusion of the CD3 zeta chain alone. IgG4-Fc (EQ) contains two point mutations in its spacer region which prevents recognition of the CAR by Fc receptors (FcRs) without altering the ability of the CAR to mediate antigen-specific lysis. CD19t, which lacks the cytoplasmic signaling tail, provides a non-immunogenic surface marker that allows for accurate measurement, efficient cell tracking and/or imaging of the therapeutic T-cells in vivo following adoptive transfer. Additionally, co-expression of CD19t functions as a \"suicide\" switch via clinically available antibodies or immunotoxins which can be used to selectively eliminate the genetically modified cells."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5401663", "l": "ORBCEL C™", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0228087", "l": "Macroglia", "d": []}, {"i": "SNOMEDCT:45766003", "d": []}]}
{"type": "biolink:Cell", "ic": "86.236661114203869", "identifiers": [{"i": "UMLS:C1515878", "l": "Activated B-Lymphocyte", "d": []}, {"i": "NCIT:C38333", "l": "Activated B-Lymphocyte", "d": ["A white blood cell produced in the bone marrow that, due to contact with an antigen, able to proliferate and differentiate into B memory cells, antibody-secreting B-lymphocytes or plasma cells."]}]}
{"type": "biolink:Cell", "ic": "79.541110464886842", "identifiers": [{"i": "CL:0000681", "l": "radial glial cell", "d": ["A cell present in the developing CNS. Functions as both a precursor cell and as a scaffold to support neuronal migration."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1267946", "l": "Lymphocyte positive for CD54 antigen", "d": []}, {"i": "SNOMEDCT:117389000", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002611", "l": "neuron of the dorsal spinal cord", "d": ["A CNS neuron of the dorsal spinal cord."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002029", "l": "Fc-epsilon RIalpha-low mast cell progenitor", "d": ["A lineage-negative, Kit-positive, CD45-positive mast cell progenitor that is Fc-epsilon RIalpha-low."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C4763554", "l": "Allogeneic HAdV Antigen-specific T-lymphocytes", "d": []}, {"i": "NCIT:C157341", "l": "Allogeneic HAdV Antigen-specific T-lymphocytes", "d": ["A population of allogeneic T-lymphocytes specifically reactive to human adenovirus (HAdV) with potential antiviral activity. Allogeneic HAdV antigen-specific T-cells are prepared via ex vivo stimulation of donor-derived peripheral blood mononuclear cells (PBMCs) with HAdV hexon protein. T-cells that secrete interferon (IFN)-gamma in response to HAdV antigen exposure are selected and expanded for administration. Infusion of the HAdV antigen-specific T-lymphocytes into hematopoietic stem cell transplant (HSCT) patients infected with HAdV may potentially reconstitute virus-specific responses, thereby controlling HAdV infections."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5170920", "l": "Leukocytes | Body fluid | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5142689", "l": "Plasma cells.polyclonal", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1148429", "l": "Unidentified cell", "d": []}, {"i": "SNOMEDCT:115425006", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5175606", "l": "Other cells | Peritoneal fluid | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "ic": "90.82444074280258", "identifiers": [{"i": "CL:0001007", "l": "interstitial dendritic cell", "d": ["Interstitial dendritic cell is a conventional dendritic cell that is CD11b-positive, CD1a-positive, CD206-positive, CD209-positive, and CD36-positive."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1518066", "l": "Lymphocyte with Abundant Pale Cytoplasm", "d": []}, {"i": "NCIT:C37028", "l": "Lymphocyte with Abundant Pale Cytoplasm", "d": []}]}
{"type": "biolink:Cell", "ic": "92.728541327098611", "identifiers": [{"i": "UMLS:C1882055", "l": "Neoplastic Large Polygonal Sertoli Cell", "d": []}, {"i": "NCIT:C61417", "l": "Neoplastic Large Polygonal Sertoli Cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5177626", "l": "Platelets Large | Blood | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C4684890", "l": "Autologous Anti-CD19 Chimeric Antigen Receptor T-cells SJCAR19", "d": []}, {"i": "NCIT:C142887", "l": "Autologous Anti-CD19 Chimeric Antigen Receptor T-cells SJCAR19", "d": ["A proprietary preparation of autologous T-lymphocytes that have been genetically modified to express a chimeric antigen receptor (CAR) targeting the tumor-associated antigen (TAA) CD19 and containing, as of yet undisclosed, costimulatory signaling domains, with potential immunostimulating and antineoplastic activities. Upon administration, autologous anti-CD19 CAR T-cells SJCAR19 target and bind to CD19-expressing tumor cells, thereby inducing selective toxicity in CD19-expressing tumor cells. CD19 antigen is a B-cell specific cell surface antigen expressed in all B-cell lineage malignancies."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5177779", "l": "Polymorphonuclear cells | Cerebral spinal fluid | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1515314", "l": "Mouse Leydig Cell", "d": []}, {"i": "NCIT:C22181", "l": "Mouse Leydig Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C4687450", "l": "Autologous TCR-engineered T-cells IMA201", "d": []}, {"i": "NCIT:C146779", "l": "Autologous TCR-engineered T-cells IMA201", "d": ["A preparation of autologous T-lymphocytes that are genetically modified with a lentiviral vector encoding a T-cell receptor (TCR) specific for an as of yet not identified tumor-associated antigen (TAA), with potential antineoplastic activity. Upon intravenous administration back into the patient, the autologous TCR-engineered T-cells IMA201 specifically recognize and bind to the TAA on cancer cells, which induces a cytotoxic T-lymphocyte (CTL)-mediated immune response against the TAA-positive cancer cells."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5171868", "l": "Macrophages | Peritoneal fluid | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:4033023", "l": "airway submucosal gland collecting duct epithelial cell", "d": ["An epithelial cell that is part of a collecting duct of an airway submucosal gland."]}]}
{"type": "biolink:Cell", "ic": "92.728541327098611", "identifiers": [{"i": "CL:0002507", "l": "langerin-positive lymph node dendritic cell", "d": ["A dermal dendritic cell isolated from skin draining lymph nodes that is langerin-positive, MHC-II-positive, and CD4-negative and CD8a-negative."]}]}
{"type": "biolink:Cell", "ic": "68.203304431560539", "identifiers": [{"i": "UMLS:C1518179", "l": "Malignant Epithelial Spindle Cell", "d": []}, {"i": "NCIT:C37109", "l": "Malignant Epithelial Spindle Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0004119", "l": "retinal ganglion cell B1", "d": ["A retinal ganglion cell B that has medium body size, medium dendritic field and dense dendritic arbor, and has post synaptic terminals in S2."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5163741", "l": "Erythrocytes.dysmorphic | Urine | Urinalysis", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5167637", "l": "HLA Ab positive cells | Serum | HLA antigens", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5184272", "l": "Tubular cells | Urine sediment | Urinalysis", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0017006", "l": "B-lymphoblast", "d": ["A lymphocyte of B lineage that has gotten larger after being stimulated by an antigen."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157483", "l": "CD33 blasts | Blood | Cell markers", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1115669", "l": "Lymphocytes.clefted", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0009023", "l": "small intestine Peyer's patch T cell", "d": ["A T cell which resides in the Peyer's patch of the small intestine."]}]}
{"type": "biolink:Cell", "ic": "70.216808612803263", "identifiers": [{"i": "CL:0000813", "l": "memory T cell", "d": ["A long-lived, antigen-experienced T cell that has acquired a memory phenotype including distinct surface markers and the ability to differentiate into an effector T cell upon antigen reexposure."]}]}
{"type": "biolink:Cell", "ic": "90.82444074280258", "identifiers": [{"i": "UMLS:C1511446", "l": "Mouse Oligodendroglial Cell", "d": []}, {"i": "NCIT:C22620", "l": "Mouse Oligodendroglial Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "90.82444074280258", "identifiers": [{"i": "CL:1001591", "l": "oviduct glandular cell", "d": ["Glandular cell of oviduct epithelium. Example: peg cells, ciliated cells."]}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "CL:0002115", "l": "B220-positive CD38-positive unswitched memory B cell", "d": ["A B220-positive CD38-positive unswitched memory B cell is a CD38-positive unswitched memory B cell that has the phenotype B220-positive, CD38-positive, IgD-positive, CD138-negative, and IgG-negative."]}]}
{"type": "biolink:Cell", "ic": "92.728541327098611", "identifiers": [{"i": "CL:0000531", "l": "primary sensory neuron (sensu Teleostei)", "d": ["A primary neuron (sensu Teleostei) that has a sensory function."]}]}
{"type": "biolink:Cell", "ic": "90.82444074280258", "identifiers": [{"i": "UMLS:C0030280", "l": "Structure of alpha Cell of islet", "d": []}, {"i": "NCIT:C32052", "l": "Alpha Cell", "d": ["A cell in the periphery of the pancreatic islets that secretes glucagon."]}, {"i": "MESH:D050416", "l": "Glucagon-Secreting Cells", "d": []}, {"i": "SNOMEDCT:61028007", "d": []}]}
{"type": "biolink:Cell", "ic": "92.728541327098611", "identifiers": [{"i": "UMLS:C4727589", "l": "Neoplastic Corticotroph Cell with Scarce Secretory Granules", "d": []}, {"i": "NCIT:C154338", "l": "Neoplastic Corticotroph Cell with Scarce Secretory Granules", "d": ["A neoplastic faintly basophilic or chromophobic PAS-positive and weakly ACTH-positive cell with scant and small secretory granules seen at the ultrastructural level."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5380987", "l": "Cells.CD8.HLA-B35 CMV specific.CMV antigen stimulated CD107a+b expressing", "d": []}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "CL:1000681", "l": "kidney cortex interstitial cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157433", "l": "CD3+CD25+ cells | XXX | Cell markers", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5163554", "l": "Epithelial cells.squamous | Body fluid | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "ic": "68.652206388559449", "identifiers": [{"i": "UMLS:C1711355", "l": "Malignant Neuroectodermal Cell", "d": []}, {"i": "NCIT:C53987", "l": "Malignant Neuroectodermal Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "82.532694649739099", "identifiers": [{"i": "UMLS:C0432608", "l": "Ringed sideroblast", "d": []}, {"i": "NCIT:C37058", "l": "Ring Sideroblast", "d": []}, {"i": "SNOMEDCT:259679003", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0003034", "l": "M5 retinal ganglion cell", "d": ["A monostratified retinal ganglion cell that has a small soma, an assymetric dendritic field with post synaptic terminals in sublaminar layer S3."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0000943", "l": "Be1 Cell", "d": ["A Be cell that facilitates development of T-helper 1 (Th1) phenotype in CD4-positive T cells, and secretes high levels of interleukin-2, tumor necrosis factor-alpha and interferon-gamma."]}]}
{"type": "biolink:Cell", "ic": "73.124874125835319", "identifiers": [{"i": "UMLS:C1513958", "l": "Neoplastic Ependymal Cell", "d": []}, {"i": "NCIT:C37143", "l": "Neoplastic Ependymal Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1511009", "l": "BG04", "d": []}, {"i": "NCIT:C20236", "l": "BG04", "d": ["Provider: BresaGen, Inc., Athens, GA. Information from provider and not independently verified by NIH: Cells are positive for cell markers SSEA-3, SSEA-4, TRA 1-60, TRA 1-81, Oct-4, and alkaline phosphatase; Cells are negative for the cell marker SSEA1. This cell line meets the criteria for the use of human embryonic stem cells by federally funded researchers."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0000565", "l": "fat body cell", "d": ["A cell found in fat bodies whose primary function is intermediary metabolism."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C3825466", "l": "Paraneurons", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:1000307", "l": "fibroblast of dense regular elastic tissue", "d": ["A fibroblast that is part of the dense regular elastic tissue."]}]}
{"type": "biolink:Cell", "ic": "78.435418415656045", "identifiers": [{"i": "CL:4023055", "l": "corticothalamic VAL/VM projecting glutamatergic neuron of the primary motor cortex", "d": ["A corticothalamic-projecting glutamatergic neuron that is located in L6 and lower L5 of the primary motor cortex, with a pyramidal morphology and mostly untufted apical dendrites terminating in midcortical layers. CT VAL/VM (ventroanterior-ventrolateral complex/ventromedial nucleus) cells have a near tonic firing pattern and are distinguished from L6 IT neurons by a lower inter-spike interval adaptation index."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5216261", "l": "Malignant cells|NCnc|Pt|Pericard fld", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0009107", "l": "lymphatic endothelial cell of subcapsular sinus ceiling", "d": ["A lymphatic endothelial cell located in the subcapsular sinus ceiling of a lymph node. In human, it's characterized by a unique marker expression (NT5e+ and Caveolin-1+)."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0333766", "l": "Moth-eaten fibers", "d": []}, {"i": "SNOMEDCT:53408006", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5173431", "l": "Monocytes | Blood cord | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1440418", "l": "Cells.t(9;22)(q22;q12.2)(NR4A3,EWSR1)", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:2000027", "l": "cerebellum basket cell", "d": ["Any basket cell that is part of a cerebellum."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5170904", "l": "Leukocyte clumps | Urine sediment | Urinalysis", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5175145", "l": "Nucleated cells | Blood | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1955314", "l": "Leukemia markers", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1276977", "l": "Entire primordial sex cell", "d": []}, {"i": "SNOMEDCT:343721007", "d": []}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "CL:1000487", "l": "smooth muscle cell of prostate", "d": ["A smooth muscle cell that is part of the prostate gland."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C3496150", "l": "A4 noradrenaline cells", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1440289", "l": "Cells.CD3+CD8+CD45RO-CD45RA-", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1183899", "l": "Luminal cell of prostatic duct", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0000947", "l": "IgE plasma cell", "d": ["A long lived plasma cell that secretes IgE."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1518313", "l": "Nevus Cell B-Type", "d": []}, {"i": "NCIT:C36865", "l": "Nevus Cell B-Type", "d": []}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "CL:0000106", "l": "unipolar neuron", "d": ["Neuron with one neurite that extends from the cell body."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0011031", "l": "monocyte-derived dendritic cell", "d": ["A dendritic cell that develops from a monocyte."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:2000042", "l": "embryonic fibroblast", "d": ["Any fibroblast that is part of a embryo."]}]}
{"type": "biolink:Cell", "ic": "84.75972595860604", "identifiers": [{"i": "UMLS:C4330475", "l": "Immune Cell", "d": []}, {"i": "NCIT:C132890", "l": "Immune Cell", "d": ["A cell in the immune system that is involved in host defense. This category may include lymphocytes, monocytes, macrophages, neutrophils, eosinophils, basophils, mast cells, and thrombocytes. Precursor cells in these lineages may also be included."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2330227", "l": "Type F cell of pancreatic acinus", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0009099", "l": "fibro/adipogenic progenitor cell", "d": ["A progenitor cell that is a tissue-resident mesenchymal cell, important for skeletal muscle regeneration, and able to differentiate into both adipocytes or fibroblasts."]}]}
{"type": "biolink:Cell", "ic": "58.3821297714628", "identifiers": [{"i": "CL:0000223", "l": "endodermal cell", "d": ["A cell of the inner of the three germ layers of the embryo."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0814997", "l": "Intestinal cell", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C3896982", "l": "Autologous CD123CAR-CD28-CD3zeta-EGFRt-expressing T Lymphocytes", "d": []}, {"i": "NCIT:C116329", "l": "Autologous CD123CAR-CD28-CD3zeta-EGFRt-expressing T Lymphocytes", "d": ["A preparation of genetically modified autologous T-cells transduced with a replication incompetent, self-inactivating lentiviral vector expressing a hinge-optimized, chimeric antigen receptor (CAR), containing a CD28 co-stimulatory signaling domain fused to CD3 zeta, the single-chain variable fragment of CD123 (Interleukin-3 receptor alpha chain or IL3RA) antigen, and a truncated form of the human epidermal growth factor receptor (EGFRt), with potential immunostimulating and antineoplastic activities. Upon intravenous administration, autologous CD123CAR-CD28-CD3zeta-EGFRt-expressing T Lymphocytes are directed to and induce selective toxicity in CD123-expressing tumor cells. CD123 is normally expressed on committed blood progenitor cells in the bone marrow; its overexpression is associated with increased leukemic cell proliferation and aggressiveness. Devoid of both ligand binding domains and tyrosine kinase activity, EGFRt both facilitates detection of the administered T-cells in vivo and can promote elimination of those cells following a cetuximab-induced antibody-dependent cellular cytotoxicity response. The costimulatory signaling domain enhances both proliferation of T-cells and antitumor activity. Hinge optimization prevents recognition of the CAR by Fc receptors (FcRs)."]}]}
{"type": "biolink:Cell", "ic": "73.124874125835319", "identifiers": [{"i": "CL:0000573", "l": "retinal cone cell", "d": ["One of the two photoreceptor cell types in the vertebrate retina. In cones the photopigment is in invaginations of the cell membrane of the outer segment. Cones are less sensitive to light than rods, but they provide vision with higher spatial and temporal acuity, and the combination of signals from cones with different pigments allows color vision."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:4030022", "l": "renal medullary fibroblast", "d": ["A fibroblast that is located in the renal medulla interstitium."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1440333", "l": "Cells.CD54", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002342", "l": "circulating endothelial cell", "d": ["A circulating endothelial cell of the phenotype CD146-positive, CD105-positive, CD45-negative. This cell type is indicative of recent vascular damage."]}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "CL:0001039", "l": "terminally differentiated osteoblast", "d": ["Osteoblast that is terminally differentiated, located adjacent to acellular or cellular bone tissue within periosteum, and is capable of mineralizing the matrix."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0000692", "l": "terminal Schwann cell", "d": ["A neuroglial cell of the peripheral nervous system inside the basal lamina of the neuromuscular junction providing chemical and physical support to the synapse."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0043380", "l": "Y-Chromosome-Bearing Sperm", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C4725083", "l": "Autologous BCMA-4-1BBz-targeted CAR T-cells", "d": []}, {"i": "NCIT:C148506", "l": "Autologous BCMA-4-1BBz-targeted CAR T-cells", "d": ["A preparation of autologous T-lymphocytes that have been ex vivo transduced with a retroviral vector expressing a chimeric antigen receptor (CAR) containing a single chain variable fragment (scFv) specific for the human tumor-associated antigen (TAA) B-cell maturation antigen (BCMA; tumor necrosis factor receptor superfamily member 17; TNFRSF17) fused to the co-stimulatory domain of 4-1BB (CD137), and the CD3-zeta (CD3z) T-cell signaling domain (4-1BBz), with potential immunostimulating and antineoplastic activities. Upon administration, the autologous BCMA-4-1BBz-targeted CAR T-cells specifically recognize and induce selective toxicity in BCMA-expressing tumor cells. BCMA, a receptor for both a proliferation-inducing ligand (APRIL) and B-cell activating factor (BAFF), is a member of the tumor necrosis factor receptor superfamily (TNFRSF). BCMA is found on the surfaces of plasma cells; it is overexpressed on malignant plasma cells, and plays a key role in plasma cell survival."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4733590", "l": "high efficiency killing T cells", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1182666", "l": "Endo-epithelial cell of viscerocranial mucosa", "d": []}]}
{"type": "biolink:Cell", "ic": "80.869303025598512", "identifiers": [{"i": "CL:0000972", "l": "class switched memory B cell", "d": ["A class switched memory B cell is a memory B cell that has undergone Ig class switching and therefore is IgM-negative on the cell surface. These cells are CD27-positive and have either IgG, IgE, or IgA on the cell surface."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1267976", "l": "Lymphocyte positive for CD86 antigen", "d": []}, {"i": "SNOMEDCT:117416001", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C2981182", "l": "Autologous EBV-CTL CD19CAR zeta", "d": []}, {"i": "NCIT:C78824", "l": "Autologous EBV-CTL CD19CAR zeta", "d": ["Autologous Epstein-Barr virus (EBV)-specific cytotoxic T-lymphocytes (CTL) that have been genetically modified to express a T-cell chimeric antigen receptor (CAR) targeting the CD19 antigen, with potential immunotherapeutic activity. The CAR consists of a single chain Fv of anti-CD19 IgG1 coupled with an intracellular signaling region of the zeta-chain of the TCR/CD3 complex (CD3 zeta). Autologous EBV-CTL CD19CAR zeta directs the T-lymphocytes to CD19-expressing tumor cells, stimulating a selective toxicity to tumor cells. CD19 antigen is a B-cell specific cell surface antigen expressed in all B-cell lineage malignancies."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0009074", "l": "medullary thymic epithelial cell type 4", "d": ["A thymic medullary epithelial cell that expresses typical tuft cell markers instead of classical mTEC or cTEC markers. This population has a bulbous-like structure."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4510905", "l": "Blast cell positive for CD16 antigen", "d": []}, {"i": "SNOMEDCT:724250006", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5426957", "l": "Epithelial cells.ciliated | Lower respiratory specimen | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1440056", "l": "Abnormal blood cells.CD7", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0545677", "l": "Alveolar cell, type 3", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2327597", "l": "Central neuroglial cell", "d": []}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "CL:0000733", "l": "lymph gland plasmatocyte", "d": ["A plasmatocyte that derives from the larval lymph gland."]}]}
{"type": "biolink:Cell", "ic": "87.120474278337809", "identifiers": [{"i": "CL:0000875", "l": "non-classical monocyte", "d": ["A type of monocyte characterized by low expression of CCR2, low responsiveness to monocyte chemoattractant CCL2/MCP1, low phagocytic activity, and decrease size relative to classical monocytes, but increased co-stimulatory activity. May also play a role in tissue repair."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1267829", "l": "T lymphocyte positive for CD16 antigen and negative for CD57 antigen", "d": []}, {"i": "SNOMEDCT:115415001", "d": []}]}
{"type": "biolink:Cell", "ic": "88.140761698499901", "identifiers": [{"i": "CL:4023071", "l": "L5/6 cck GABAergic interneuron (Mmus)", "d": ["A GABAergic cortical interneuron that expresses cck. L5/6 cck cells have soma found mainly in L5 and L6 and have large axonal arborization."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1267870", "l": "Lymphocyte positive for CD12 antigen", "d": []}, {"i": "SNOMEDCT:117549007", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5420490", "l": "CD123-CD33 Compound CAR T Cells", "d": []}, {"i": "NCIT:C173970", "l": "CD123-CD33 Compound CAR T Cells", "d": ["A preparation of T-lymphocytes transduced with a lentiviral vector expressing a compound chimeric antigen receptor (cCAR) containing two distinct units of CARs, one specific for the CD123 (interleukin-3 receptor alpha chain or IL3RA) antigen and one specific for the CD33 antigen, with potential immunomodulating and antineoplastic activities. Upon administration, the CD123-CD33 cCAR T cells specifically and simultaneously target and bind to tumor cells expressing CD123 and/or CD33. This induces selective toxicity in tumor cells that express the CD123 antigen and/or the CD33 antigen. CD123 is normally expressed on committed blood progenitor cells in the bone marrow; its overexpression is associated with increased leukemic cell proliferation and aggressiveness. CD33 is expressed on normal non-pluripotent hematopoietic stem cells and is overexpressed on myeloid leukemia cells. Targeting two different antigens may improve coverage and protect against antigen escape and relapse as it is less likely for tumor cells to lose both antigens. Additionally, the CD123-CD33 cCAR T cells express CD52 on the cell surface. This allows the depletion of the CD123-CD33 cCAR T cells with the administration of the anti-CD52 monoclonal antibody alemtuzumab, in case of unacceptable side effects."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C4725019", "l": "Partially HLA-matched Adenovirus-specific T Lymphocytes", "d": []}, {"i": "NCIT:C148419", "l": "Partially HLA-matched Adenovirus-specific T Lymphocytes", "d": ["A population of frozen, off-the-shelf, ready to administer, allogeneic, partially or closely human leukocyte antigen (HLA) matched cytotoxic T-lymphocytes (CTLs) specifically reactive to human adenovirus (Ad; AdV), with potential immunomodulating and anti-adenoviral activities. Ex vivo, Ad-derived peptides were mixed with peripheral blood mononuclear cells (PBMCs) from healthy donors and the Ad-reactive CTLs were selected, grown and frozen. Upon thawing and infusion, the partially HLA-matched Ad-specific CTLs may help reconstitute Ad-specific CTL responses in patients at risk of developing Ad infections after allogeneic stem cell transplant (HSCT) or in Ad-infected immunocompromised hosts. This may induce killing of Ad-infected cells and may prevent or reduce severity of Ad infection."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C3831515", "l": "Anti-EGFRvIII CAR-transduced Allogeneic T-lymphocytes", "d": []}, {"i": "NCIT:C111565", "l": "Anti-EGFRvIII CAR-transduced Allogeneic T-lymphocytes", "d": ["Allogeneic human T-lymphocytes transduced with a retroviral vector encoding an anti-epidermal growth factor receptor (EGFR) variant III (EGFRvIII) mutant chimeric T cell receptor (chimeric antigen receptor or CAR) gene coupled to the signaling domains from CD8, CD28, 4-1BB (CD137) and CD3 zeta, with potential immunostimulatory and antineoplastic activities. Upon administration, the anti-EGFRvIII CAR-transduced allogeneic T lymphocytes bind to the EGFRvIII antigen on tumor cell surfaces; subsequently, EGFRvIII-expressing tumor cells may be lysed. EGFRvIII, an in-frame deletion of exons 2-7 in the EGFR gene, is overexpressed by a variety of cancer cell types and absent in normal, healthy cells; it plays a key role in tumor cell proliferation, tumor angiogenesis and radio- and chemoresistance."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C0023172", "l": "Lupus erythematosus cell", "d": []}, {"i": "NCIT:C36716", "l": "LE Cell", "d": ["The lupus erythematosus cell, which is likely a neutrophil with denatured nuclei. It may be found in blood, bone marrow, synovial fluid, cerebrospinal fluid, pericardial and pleural effusions of individuals with lupus erythematosus."]}, {"i": "SNOMEDCT:7055007", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157439", "l": "CD3+CD4+ (T4 helper) cells | XXX | Cell markers", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2322820", "l": "Vacuolar absorptive cell of epithelium of colon", "d": []}]}
{"type": "biolink:Cell", "ic": "89.347505587204751", "identifiers": [{"i": "CL:1001451", "l": "sensory neuron of dorsal root ganglion", "d": ["A sensory neuron of the dorsal root ganglia that senses body position and sends information about how much the muscle is stretched to the spinal cord."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1268007", "l": "Myeloid precursor cell", "d": []}, {"i": "SNOMEDCT:127914007", "d": []}]}
{"type": "biolink:Cell", "ic": "79.849015605436421", "identifiers": [{"i": "CL:0000895", "l": "naive thymus-derived CD4-positive, alpha-beta T cell", "d": ["An antigen inexperienced CD4-positive, alpha-beta T cell with the phenotype CCR7-positive, CD127-positive and CD62L-positive. This cell type develops in the thymus. This cell type is also described as being CD25-negative, CD62L-high, and CD44-low."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2336812", "l": "Type X enteroendocrine cell", "d": []}]}
{"type": "biolink:Cell", "ic": "82.076046914303362", "identifiers": [{"i": "UMLS:C1520127", "l": "Warthin-Finkeldey Polykaryocyte", "d": []}, {"i": "NCIT:C36812", "l": "Warthin-Finkeldey Polykaryocyte", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5380990", "l": "Cells.CD8.HLA-A2 CMV specific.CMV antigen stimulated CD107a+b expressing", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2327104", "l": "Velate protoplasmic astrocyte", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5170932", "l": "Leukocytes | Nose | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1512121", "l": "EG Cell Line", "d": []}, {"i": "NCIT:C20231", "l": "EG Cell Line", "d": ["Human EG cells are derived from the primordial germ cells, which occurs in a specific part of the embryo/fetus called the gonadal ridge, and which normally develop into mature gametes (eggs and sperm). Growing pluripotent cells derived from EG cells requires the generation of embryoid bodies, which consist of an unpredictable mix of partially differentially cell types."]}]}
{"type": "biolink:Cell", "ic": "92.728541327098611", "identifiers": [{"i": "CL:1001033", "l": "peritubular capillary endothelial cell", "d": ["An endothelial cell that is part of some peritubular capillary."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5777115", "l": "Cytochrome P450 isoform 2B1 gene transfected human embryonic kidney 293 cells encapsulated in polymeric cellulose sulphate", "d": []}]}
{"type": "biolink:Cell", "ic": "92.728541327098611", "identifiers": [{"i": "UMLS:C1517725", "l": "Neoplastic Large Erythroblast", "d": []}, {"i": "NCIT:C37059", "l": "Neoplastic Large Erythroblast", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C4723770", "l": "Autologous Natural Killer Cell-like CTLs", "d": []}, {"i": "NCIT:C156168", "l": "Autologous Natural Killer Cell-like CTLs", "d": ["A preparation of cytotoxic T-lymphocytes (CTLs) that express natural killer (NK)-like features (nCTLs), with potential immunomodulating and antineoplastic activities. The nCTLs are derived from autologous lymphocytes that have been in vitro exposed to autologous alpha-type-1 polarized dendritic cells that are pulsed with specific autologous tumor-associated antigens (TAAs); the nCTLs are subsequently expanded in the presence of the cytokine human interleukin-2 (IL-2). The generated nCTLs are potent CTLs that produce high amounts of granzyme B and perforin, and interferon-gamma (IFNg) with high killer activity and tumor-homing potential. Upon infusion of the autologous nCTLs, these cells specifically recognize the TAAs on the tumor cells, then bind to and directly lyse tumor cells."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1440254", "l": "Cells.CD128", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157921", "l": "Cells | Cervical mucus | Fertility testing", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157619", "l": "CD56 cells | XXX | Cell markers", "d": []}]}
{"type": "biolink:Cell", "ic": "71.079643100360357", "identifiers": [{"i": "CL:0000018", "l": "spermatid", "d": ["A male germ cell that develops from the haploid secondary spermatocytes. Without further division, spermatids undergo structural changes and give rise to spermatozoa."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0599856", "l": "Muscle satellite cell", "d": []}, {"i": "MESH:D032496", "l": "Satellite Cells, Skeletal Muscle", "d": []}]}
{"type": "biolink:Cell", "ic": "87.120474278337809", "identifiers": [{"i": "UMLS:C1514172", "l": "Pleomorphic Epithelial Cell", "d": []}, {"i": "NCIT:C37170", "l": "Pleomorphic Epithelial Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "92.728541327098611", "identifiers": [{"i": "CL:0000567", "l": "polymodal nocireceptor", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1718725", "l": "Cells.CD1c+CD22+", "d": []}]}
{"type": "biolink:Cell", "ic": "92.728541327098611", "identifiers": [{"i": "CL:0002350", "l": "endocardial cell", "d": ["An endothelial cell that lines the intracavitary lumen of the heart, separating the circulating blood from the underlying myocardium. This cell type releases a number of vasoactive substances including prostacyclin, nitrous oxide and endothelin."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5707052", "l": "Anti-mesothelin CAR Vector-transduced T-lymphocytes", "d": []}, {"i": "NCIT:C187372", "l": "Anti-mesothelin CAR Vector-transduced T-lymphocytes", "d": ["A preparation of genetically modified T-lymphocytes transduced with a lentiviral vector encoding a chimeric antigen receptor (CAR) specific for the human tumor-associated antigen (TAA) mesothelin (MSLN), with potential immunomodulating and antineoplastic activities. Upon administration, the anti-MSLN CAR vector-transduced T-lymphocytes specifically target and kill MSLN-expressing tumor cells. MSLN, a cell surface glycoprotein involved in cell adhesion, is overexpressed in a variety of cancer cell types."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0019015", "l": "lung parenchyma resident eosinophil", "d": ["An eosinophil with a ring-shaped nucleus that is resident in the lung parenchyma. In mouse, lung parenchyma resident eosinophils are IL-5-independent Siglec-F(intermediate) CD62L+ CD101(low). In human, they are Siglec-8+ CD62L+ IL-3R(low)."]}]}
{"type": "biolink:Cell", "ic": "92.728541327098611", "identifiers": [{"i": "CL:0002071", "l": "enterocyte of epithelium of large intestine", "d": ["Columnar cell which populate the epithelium of large intestine and absorb water. This cell is the most numerous of the epithelial cell types in the large intestine; bear apical microvilli, contain secretory granules in their apical cytoplasm; secretion appears to be largely mucins, but is also rich in antibodies of the IgA type."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1440343", "l": "Cells.CD66a", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5171665", "l": "Lymphocytes | Pleural fluid | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1317495", "l": "Leukocyte clumps", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5216269", "l": "Monoblasts|NCnc|Pt|Bld", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4511162", "l": "Blast cell positive for cytoplasmic CD22 antigen", "d": []}, {"i": "SNOMEDCT:725482003", "d": []}]}
{"type": "biolink:Cell", "ic": "73.721563224321088", "identifiers": [{"i": "UMLS:C1711288", "l": "Primitive Round to Oval Cell", "d": []}, {"i": "NCIT:C53980", "l": "Primitive Round to Oval Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "75.923665061460838", "identifiers": [{"i": "UMLS:C1514809", "l": "Reed-Sternberg-Like Cell", "d": []}, {"i": "NCIT:C37024", "l": "Reed-Sternberg-Like Cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157307", "l": "CD14 blasts | Blood | Cell markers", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1831990", "l": "Autologous Anti-gp100:154-162 T-Cell Receptor Gene-Engineered Peripheral Blood Lymphocytes", "d": []}, {"i": "NCIT:C71748", "l": "Autologous Anti-gp100:154-162 T-Cell Receptor Gene-Engineered Peripheral Blood Lymphocytes", "d": ["Human autologous peripheral blood lymphocytes (PBLs) transduced with a glycoprotein 100 (gp100) epitope-determined T cell receptor (TCR) gene, with potential antineoplastic activity. PBLs are isolated from a melanoma patient and pulsed with a viral vector encoding the TCR specific for amino acid residues 154-162 of gp100 (KTWGQYWQV). After expansion ex vivo, the transduced autologous PBLs, expressing this specific TCR, are reintroduced into the patient and bind to melanoma cells expressing the gp100 protein, which may result in specific cytotoxic T-lymphocyte (CTL) killing of gp100-expressing melanoma cells. gp100 is a melanocyte lineage-specific antigen overexpressed in melanomas."]}]}
{"type": "biolink:Cell", "ic": "83.552982069901191", "identifiers": [{"i": "UMLS:C1513982", "l": "Neoplastic Somatotroph Cell", "d": []}, {"i": "NCIT:C36919", "l": "Neoplastic Somatotroph Cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4301985", "l": "Motile spermatozoa", "d": []}, {"i": "SNOMEDCT:723202000", "d": []}]}
{"type": "biolink:Cell", "ic": "56.959548363731535", "identifiers": [{"i": "CL:0000355", "l": "multi-potent skeletal muscle stem cell", "d": ["A multifate stem cell found in skeletal muscle than can differentiate into many different cell types, including muscle. Distinct cell type from satellite cell."]}]}
{"type": "biolink:Cell", "ic": "92.728541327098611", "identifiers": [{"i": "UMLS:C0229640", "l": "Segmented neutrophil", "d": []}, {"i": "NCIT:C36719", "l": "Segmented Neutrophil", "d": ["A mature neutrophil with a nucleus having distinct lobes connected by filaments."]}]}
{"type": "biolink:Cell", "ic": "82.532694649739099", "identifiers": [{"i": "CL:0000378", "l": "supporting cell (sensu Nematoda and Protostomia)", "d": []}]}
{"type": "biolink:Cell", "ic": "92.728541327098611", "identifiers": [{"i": "UMLS:C1519322", "l": "Signet Ring Stromal Cell", "d": []}, {"i": "NCIT:C36902", "l": "Signet Ring Stromal Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "74.953330836288131", "identifiers": [{"i": "CL:0000168", "l": "insulin secreting cell", "d": []}]}
{"type": "biolink:Cell", "ic": "78.185623981295834", "identifiers": [{"i": "CL:0000552", "l": "orthochromatic erythroblast", "d": ["The final stage of the nucleated, immature erythrocyte, before nuclear loss. Typically the cytoplasm is described as acidophilic, but it still shows a faint polychromatic tint. The nucleus is small and initially may still have coarse, clumped chromatin, as in its precursor, the polychromatophilic erythroblast, but ultimately it becomes pyknotic, and appears as a deeply staining, blue-black, homogeneous structureless mass. The nucleus is often eccentric and sometimes lobulated."]}]}
{"type": "biolink:Cell", "ic": "61.841543847919574", "identifiers": [{"i": "UMLS:C1510731", "l": "Abnormal Myeloid Cell", "d": []}, {"i": "NCIT:C37042", "l": "Abnormal Myeloid Cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "MESH:D016131", "l": "Lymphocyte Subsets", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5554926", "l": "Partially HLA-matched AdV/CMV/EBV/BKV-specific Allogeneic T-lymphocytes", "d": []}, {"i": "NCIT:C178297", "l": "Partially HLA-matched AdV/CMV/EBV/BKV-specific Allogeneic T-lymphocytes", "d": ["A preparation of partially human leukocyte antigen (HLA)-matched allogeneic cytotoxic T-lymphocytes (CTLs) that are specifically reactive to the four viruses adenovirus (AdV), cytomegalovirus (CMV), Epstein-Barr virus (EBV) and human polyomavirus type I (BKV), with potential antiviral activity. Upon infusion of the partially HLA-matched AdV/CMV/EBV/BKV-specific allogeneic T-lymphocytes upon allogeneic hematopoietic stem cell transplantation (HSCT) in an immunodeficient recipient, these CTLs may kill AdV, CMV, EBV and/or BKV-infected cells, and may prevent or reduce the severity of viral infections by these pathogens."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C3658289", "l": "Human Induced Pluripotent Stem Cells", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1440385", "l": "Cells.euploid+Cells.aneuploid.population 1", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5175604", "l": "Other cells | Body fluid | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1832043", "l": "TALL-104", "d": []}, {"i": "NCIT:C66980", "l": "Human MHC Non-Restricted Cytotoxic T-Cell Line TALL-104", "d": ["An allogeneic human cytotoxic T-lymphocyte cell line (TALL-104) with potential antineoplastic activity. TALL-104 is an IL-2-dependent human leukemic T cell line, expressing CD8 and T-cell receptor CD3, but not CD16. Because these cells are endowed with MHC-non-restricted killer activity, TALL-104 has destructive potential against a broad range of tumors, while sparing normal cells. Upon administration, TALL-104 targets and interacts with tumor cells and activates apoptotic and necrotic pathways, eventually leading to lysis of tumor cells. In addition, TALL-104 may induce secretion of various cytokines, such as interferon-gamma, thereby potentially enhancing the cytotoxic activity."]}]}
{"type": "biolink:Cell", "ic": "89.347505587204751", "identifiers": [{"i": "CL:1000223", "l": "lung neuroendocrine cell", "d": ["A neuroendocrine cell that is part of respiratory epithelium of the lung and is involved in the sensory detection of environmental stimuli, including hypoxia, nicotine and air pressure. Ultrastructurally, this cell type is characterized by the presence of cytoplasmic dense core granules, which are considered the storage sites of amine and peptide hormones. Lung neuroendocrine cells are innervated and appear as solitary cells or as clustered masses, localized at airway bifurcation sites, called neuroepithelial bodies that can release serotonin in response to hypoxia and interact with sensory nerve terminals. Lung neuroendocrine cells also function as reserve stem cells that repair the surrounding epithelium after injury."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2924226", "l": "Cells.CD5+CD23+", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0883208", "l": "Lymphoma cells", "d": []}]}
{"type": "biolink:Cell", "ic": "76.857431420584163", "identifiers": [{"i": "UMLS:C1515879", "l": "Activated Lymphocyte", "d": []}, {"i": "NCIT:C32049", "l": "Activated Lymphocyte", "d": ["A white blood cell that, after being in contact with an antigen, rearranges its DNA to defend against that one specific type of antigen. After activation, it can then proliferate and differentiate into memory cells, antibody-secreting cells or plasma cells."]}]}
{"type": "biolink:Cell", "ic": "92.728541327098611", "identifiers": [{"i": "CL:0000109", "l": "adrenergic neuron", "d": []}]}
{"type": "biolink:Cell", "ic": "92.728541327098611", "identifiers": [{"i": "CL:0002044", "l": "Kit-positive, integrin beta7-high basophil mast progenitor cell", "d": ["A basophil mast progenitor cell that is Beta-7 integrin-high, Kit-positive FcRgammaII/III-positive and Sca1-negative."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C2986886", "l": "Rapamycin-Polarized Th1/Tc1 Autologous T Lymphocytes", "d": []}, {"i": "NCIT:C95080", "l": "Rapamycin-Polarized Th1/Tc1 Autologous T Lymphocytes", "d": ["A population of T lymphocytes polarized by rapamycin with potential immunomodulating activity. The autologous T cells collected from the patient were co-stimulated with antibodies to the T-cell cell surface proteins CD3 and CD28 and expanded ex vivo in the presence of rapamycin, an immunosuppressive drug, and then infused back into the same patient. Both CD3 and CD28 are required for full T-cell activation. These lymphocytes expressed anti-apoptotic bcl-2 family member proteins (reduced Bax, Bak; increased phospho-Bad); maintained mitochondrial membrane potentials; and displayed reduced apoptosis. Adoptive transfer of this type of T cell potentially induces an anti-apoptotic Th1/Tc1 effector phenotype by promoting autophagy."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1440329", "l": "Cells.CD50", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C4725691", "l": "Autologous Anti-CD19 CAR TCR-zeta/4-1BB-transduced T Lymphocytes BinD19", "d": []}, {"i": "NCIT:C150378", "l": "Autologous Anti-CD19 CAR TCR-zeta/4-1BB-transduced T Lymphocytes BinD19", "d": ["Autologous T-lymphocytes that have been transduced with a lentiviral vector to express a T-cell receptor (TCR) consisting of a single chain variable fragment (scFv) of anti-CD19 coupled to the co-stimulatory molecule 4-1BB (CD137) and to the cytoplasmic portion of the zeta chain of the human T-cell receptor (CD3zeta), with potential immunostimulating and antineoplastic activities. Upon transfusion, the autologous anti-CD19 CAR TCR-zeta/4-1BB-transduced T-lymphocytes BinD19 target and bind to CD19-expressing neoplastic B-cells. This results in a cytotoxic T-lymphocyte (CTL) response against CD19-expressing tumor cells, the release of cytotoxic molecules and tumor cell lysis. CD19, cluster of differentiation 19, is a B-cell-specific cell surface antigen overexpressed in B-cell lineage tumors. Incorporation of the costimulatory signaling domains increases human T-cell function, expansion, and survival."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C3640934", "l": "Adenovirus Encoding Tyrosinase/MART-1/MAGEA6-transduced Autologous Dendritic Cell Vaccine", "d": []}, {"i": "NCIT:C102753", "l": "Adenovirus Encoding Tyrosinase/MART-1/MAGEA6-transduced Autologous Dendritic Cell Vaccine", "d": ["A cell-based cancer vaccine composed of autologous dendritic cells (DCs) transduced with a recombinant adenoviral vector encoding three full length human melanoma associated antigens (MAAs), tyrosinase, melan-A (MART-1) and the melanoma antigen A6 (MAGEA6), with potential antineoplastic activity. Upon intradermal administration, adenovirus encoding tyrosinase/MART-1/MAGEA6-transduced autologous DC vaccine may stimulate a cytotoxic T lymphocyte (CTL) response against tyrosinase/MART-1/MAGEA6-positive tumor cells, which may result in tumor cell death and decreased tumor growth. Tyrosinase, a melanoma-specific differentiation antigen, catalyzes the first step of melanin synthesis in melanocytes. Vaccination with multi-antigen modified DC may improve the efficacy of the DC immunotherapy."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5706560", "l": "Allogeneic DNT Cells RC1012", "d": []}, {"i": "NCIT:C189910", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157399", "l": "CD227 cells | Blood | Cell markers", "d": []}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "UMLS:C1183499", "l": "Mesodermal cell", "d": []}, {"i": "NCIT:C33936", "l": "Mesoderm Cell", "d": ["An embryonic cell of the middle layer of three germ layers that gives rise to the musculoskeletal, vascular, urogenital systems, and connective tissue."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4738963", "l": "Leukocytes.DNA+Plasma.cfDNA", "d": []}]}
{"type": "biolink:Cell", "ic": "48.792296854794387", "identifiers": [{"i": "UMLS:C1512108", "l": "Dysplastic Squamous Cell", "d": []}, {"i": "NCIT:C36789", "l": "Dysplastic Squamous Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5556476", "l": "Autologous Anti-CD19 CAR-T Cells CRC01", "d": []}, {"i": "NCIT:C180584", "l": "Autologous Anti-CD19 CAR-T Cells CRC01", "d": ["A preparation of autologous T-lymphocytes that have been genetically modified to express a chimeric antigen receptor (CAR) specific for the tumor-associated antigen (TAA) CD19, with potential immunostimulating and antineoplastic activities. Upon administration, autologous anti-CD19 CAR-T cells CRC01 target and bind to CD19-expressing tumor cells. This results in a cytotoxic T-lymphocyte (CTL) response against CD19-expressing tumor cells and tumor cell lysis. CD19 is a B-cell-specific cell surface antigen overexpressed in B-cell lineage tumors."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0000532", "l": "CAP motoneuron", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1181286", "l": "Intermediate epitheliocyte", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:4033038", "l": "lung resident memory CD4-positive, alpha-beta T cell", "d": ["An alpha-beta CD4 T cell that resides in the lung."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1257910", "l": "Aneuploid Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "80.17194633000733", "identifiers": [{"i": "CL:0002352", "l": "gestational hematopoietic stem cell", "d": ["A hematopoietic stem cell that exists during embryogenesis."]}]}
{"type": "biolink:Cell", "ic": "64.546003967123667", "identifiers": [{"i": "CL:4033050", "l": "catecholaminergic neuron", "d": ["A neuron that releases catecholamine as a neurotransmitter."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0682643", "l": "resting or wandering histiocyte", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0009030", "l": "enteroendocrine cell of appendix", "d": ["An intestinal enteroendocrine cell that is located in a vermiform appendix."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0231011", "l": "Ootid", "d": []}, {"i": "SNOMEDCT:49268005", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5417766", "l": "Temferon", "d": []}]}
{"type": "biolink:Cell", "ic": "92.728541327098611", "identifiers": [{"i": "CL:0000619", "l": "supporting cell (sensu Nematoda)", "d": []}]}
{"type": "biolink:Cell", "ic": "67.292420608345139", "identifiers": [{"i": "UMLS:C1181052", "l": "Thyroid Gland Follicular Cell", "d": []}, {"i": "NCIT:C33783", "l": "Thyroid Gland Follicular Cell", "d": ["An epithelial cell lining the thyroid follicles."]}, {"i": "MESH:D000072637", "l": "Thyroid Epithelial Cells", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0009111", "l": "centrocyte", "d": ["A germinal center B cell found in a lymph node germinal center light zone."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4510901", "l": "Blast cell positive for CD117 antigen", "d": []}, {"i": "SNOMEDCT:724245000", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5206714", "l": "Indium In 111-Autologous CMV-pp65-LAMP mRNA Loaded Dendritic Cells", "d": []}, {"i": "NCIT:C162641", "l": "Indium In 111-Autologous CMV-pp65-LAMP mRNA Loaded Dendritic Cells", "d": ["A radioimmunoconjugate composed of mature autologous dendritic cells (DCs) generated from peripheral blood leukocytes pulsed with mRNA encoding for a fusion protein comprised of the human cytomegalovirus (CMV) matrix protein pp65 (65 kDa lower matrix phosphoprotein; UL83) fused with the lysosome-associated membrane protein (pp65-LAMP) and radiolabeled with the isotope indium In 111, with potential ability to track DC migration upon single-photon emission computed tomography (SPECT)/ computed tomography (CT). Upon intradermal injection of the indium In 111-autologous CMV pp65-LAMP mRNA loaded DCs into the groin area, the DCs migrate in vivo to the inguinal lymph nodes. Upon SPECT/CT imaging, DC in vivo migration to the lymph nodes can be assessed."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5163712", "l": "Erythrocytes | Bronchoalveolar lavage | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:4030009", "l": "epithelial cell of proximal tubule segment 1", "d": ["Epithelial cell that is part of segment 1 (S1) of the proximal tubule epithelium."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2339194", "l": "Supporting cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5549471", "l": "CD154 cells | T cells | Cell markers", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5237032", "l": "Antigen-presenting Cells-expressing HPV16 E6/E7 SQZ-PBMC-HPV", "d": []}, {"i": "NCIT:C165256", "l": "Antigen-presenting Cells-expressing HPV16 E6/E7 SQZ-PBMC-HPV", "d": ["A preparation of antigen presenting cells (APCs) specific for human papillomavirus (HPV) type 16 E6 and E7 proteins, with potential immunomodulating and antineoplastic activities. Autologous peripheral blood mononuclear cells (PBMCs) were ex vivo manipulated, using a technique involving membrane disruption to get the HPV16 E6 and E7 proteins into the cells; the resulting APCs present the antigens in a major histocompatibility type I (MHC-I) manner.  Upon administration of the APCs-expressing HPV16 E6/E7 SQZ-PBMC-HPV, these cells activate the immune system to mount a cytotoxic T-lymphocyte (CTL) immune response against tumor cells expressing HPV16 E6 and E7.  HPV16 E6 and E7 play an important role in the development of certain types of cancer."]}]}
{"type": "biolink:Cell", "ic": "76.659841615658792", "identifiers": [{"i": "CL:0000601", "l": "cochlear outer hair cell", "d": ["A mechanoreceptor in the organ of Corti. In mammals the outer hair cells are arranged in three rows which are further from the modiolus than the single row of inner hair cells. The motile properties of the outer hair cells may contribute actively to tuning the sensitivity and frequency selectivity of the cochlea."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2330686", "l": "Transitional myocyte of right branch of atrioventricular bundle", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5700423", "l": "AUTO1 CAR-T Cells", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1182803", "l": "Epithelial cell of exocrine pancreas", "d": []}]}
{"type": "biolink:Cell", "ic": "52.749503262542355", "identifiers": [{"i": "CL:0000115", "l": "endothelial cell", "d": ["An endothelial cell comprises the outermost layer or lining of anatomical structures and can be squamous or cuboidal. In mammals, endothelial cell has vimentin filaments and is derived from the mesoderm."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1317198", "l": "Cells.CD55", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002547", "l": "fibroblast of the aortic adventitia", "d": ["A fibroblast of the aortic adventitia."]}]}
{"type": "biolink:Cell", "ic": "66.880045726402614", "identifiers": [{"i": "UMLS:C0682523", "l": "Human Cell Line", "d": []}, {"i": "NCIT:C20218", "l": "Human Cell Line", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1515150", "l": "TE32", "d": []}, {"i": "NCIT:C20297", "l": "TE32", "d": ["Provider: Technion University, Haifa, Israel. No information from provider. This cell line meets the criteria for the use of human embryonic stem cells by federally funded researchers."]}]}
{"type": "biolink:Cell", "ic": "68.312708028507217", "identifiers": [{"i": "UMLS:C1708871", "l": "Malignant Endothelial Cell", "d": []}, {"i": "NCIT:C47834", "l": "Malignant Endothelial Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:1000478", "l": "transitional myocyte of sinoatrial node", "d": ["A transitional myocyte that is part of the sinoatrial node."]}]}
{"type": "biolink:Cell", "ic": "86.236661114203869", "identifiers": [{"i": "CL:0000884", "l": "mucosa-associated lymphoid tissue macrophage", "d": ["A tissue-resident macrophage found in the mucosa associated lymphoid tissue."]}]}
{"type": "biolink:Cell", "ic": "84.128890093485552", "identifiers": [{"i": "UMLS:C5706884", "l": "TPIT-Lineage Adenohypophysial Cell", "d": []}, {"i": "NCIT:C187079", "l": "TPIT-Lineage Adenohypophysial Cell", "d": ["An adenohypophysial cell determined by the expression of T-box transcription factor TPIT."]}]}
{"type": "biolink:Cell", "ic": "80.511444690059548", "identifiers": [{"i": "CL:0000448", "l": "white fat cell", "d": ["Fat cells with light coloration and few mitochondria. They contain a scant ring of cytoplasm surrounding a single large lipid droplet or vacuole."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1180241", "l": "Endothelial cell of arteriole", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0598117", "l": "stellate cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1267973", "l": "Lymphocyte positive for CD82 antigen", "d": []}, {"i": "SNOMEDCT:117413009", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157266", "l": "CD11a blasts | Bone marrow | Cell markers", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1182618", "l": "Epithelial cell of lacrimal duct", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1511548", "l": "Cryopreserved Cell", "d": []}, {"i": "NCIT:C19314", "l": "Cryopreserved Cell", "d": ["Cells which are indefinitely maintained in a viable state at extremely low temperatures."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2963388", "l": "Bizarre platelets", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002296", "l": "type-4 epithelial cell of thymus", "d": ["An epithelial cell with high nuclear and cytoplasmic electron-density. This cell type is found in the deeper portions of the cortex but is more abundant in the medulla of the thymus."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0000756", "l": "type 4 cone bipolar cell (sensu Mus)", "d": ["An OFF-bipolar neuron found in the retina and having connections with cone photoreceptors cells and neurons in the outer half of the inner plexiform layer. The cell has a diffuse axon terminal with varicosities in sublaminae 1 and 2 of the inner plexiform layer."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:1000695", "l": "kidney interstitial alternatively activated macrophage", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0427532", "l": "Hypergranular white blood cell", "d": []}, {"i": "SNOMEDCT:250291005", "d": []}]}
{"type": "biolink:Cell", "ic": "85.457082654197222", "identifiers": [{"i": "CL:0002082", "l": "type II cell of adrenal medulla", "d": ["A chromaffin cell of the adrenal medulla that produces epinephrine."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0000587", "l": "cold sensing thermoreceptor cell", "d": ["A thermoreceptor cell that detects reduced temperatures."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5761404", "l": "Cell positive for progesterone receptor", "d": []}, {"i": "SNOMEDCT:1234916001", "d": []}]}
{"type": "biolink:Cell", "ic": "87.120474278337809", "identifiers": [{"i": "UMLS:C1519600", "l": "Transformed Peripheral B-Lymphocyte", "d": []}, {"i": "NCIT:C38658", "l": "Transformed Peripheral B-Lymphocyte", "d": ["A mature lymphocyte that has entered the peripheral blood system and has been activated into one of several mature B-cell subtypes."]}]}
{"type": "biolink:Cell", "ic": "73.124874125835319", "identifiers": [{"i": "CL:0000646", "l": "basal cell", "d": ["Undifferentiated; mitotic stem cell for other epithelial cell types; rounded or elliptical with little cytoplasm and few organelles; contain cytokeratin intermediate filament."]}]}
{"type": "biolink:Cell", "ic": "92.728541327098611", "identifiers": [{"i": "UMLS:C1882962", "l": "Round Adenocarcinoma Cell with Abundant Cytoplasm and Vesicular Nucleus", "d": []}, {"i": "NCIT:C54689", "l": "Round Adenocarcinoma Cell with Abundant Cytoplasm and Vesicular Nucleus", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1181967", "l": "Chromaffin cell of adrenal cortex", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0229424", "l": "Infantile diploetic mastoid cell", "d": []}, {"i": "SNOMEDCT:87056002", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1440048", "l": "Abnormal blood cells.CD10", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5556441", "l": "Allogeneic CRISPR/Cas9-edited CD33-depleted CD34-positive Hematopoietic Stem and Progenitor Cells VOR33", "d": []}, {"i": "NCIT:C180524", "l": "Allogeneic CRISPR/Cas9-edited CD33-depleted CD34-positive Hematopoietic Stem and Progenitor Cells VOR33", "d": ["A preparation of allogeneic, human leukocyte antigen (HLA) matched, cluster of differentiation 34 (CD34)-positive human hematopoietic stem and progenitor cells (HSPCs) that are ex-vivo gene-edited with the clustered regularly interspaced short palindromic repeats (CRISPR)-Cas9 nuclease complex to remove the cluster of differentiation 33 (CD33) antigen, that can potentially be used to improve hematopoietic recovery after hematopoietic cell transplantation (HCT) and CD33-targeting chemotherapy. Upon administration of allogeneic CRISPR/Cas9-edited CD33-depleted CD34-positive HSPCs VOR33, these cells increase and restore the number of HSPCs, which may prevent or decrease infection and other complications of HCT and chemotherapy-induced neutropenia (CIN). The removal of CD33 protects VOR33 from the cytotoxic effects of CD33-targeted agents administered after HCT."]}]}
{"type": "biolink:Cell", "ic": "73.011730055819953", "identifiers": [{"i": "UMLS:C1512084", "l": "Ductal Carcinoma Cell", "d": []}, {"i": "NCIT:C36858", "l": "Ductal Carcinoma Cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4304493", "l": "Population of all target cells in portion of fluid", "d": []}, {"i": "SNOMEDCT:719695006", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5690737", "l": "M Cells, Intestinal", "d": []}]}
{"type": "biolink:Cell", "ic": "75.42073205405498", "identifiers": [{"i": "CL:0002429", "l": "CD69-positive double-positive thymocyte", "d": ["A double-positive thymocyte that is CD69-positive and has begun positive selection."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1979667", "l": "Cells.CD19+IgA+", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2936184", "l": "Fibroblast-Derived Induced Pluripotent Stem Cells", "d": []}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "UMLS:C1514584", "l": "Pseudo-Gaucher Cell", "d": []}, {"i": "NCIT:C37078", "l": "Pseudo-Gaucher Cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5186802", "l": "Macrophages | Fetus | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0004161", "l": "510 nm-cone", "d": ["A cone whose sensitivity measurements have an average spectral peak of 510 nm. These cones are described in rat."]}]}
{"type": "biolink:Cell", "ic": "77.944915021140389", "identifiers": [{"i": "UMLS:C1711385", "l": "Primitive Malignant Skeletal Muscle Cell", "d": []}, {"i": "NCIT:C49202", "l": "Primitive Malignant Skeletal Muscle Cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1267857", "l": "Lymphocyte positive for both CD8 antigen and CD56 antigen", "d": []}, {"i": "SNOMEDCT:116816001", "d": []}]}
{"type": "biolink:Cell", "ic": "84.75972595860604", "identifiers": [{"i": "CL:0000682", "l": "M cell of gut", "d": ["An absorptive cell of the gut epithelium that endocytoses microorganisms and intact macromolecules from the gut lumen and transports them to the subepithelial space where they are presented to antigen-presenting cells and lymphocytes."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1517820", "l": "Mouse Pro-T-Lymphocyte", "d": []}, {"i": "NCIT:C22581", "l": "Mouse Pro-T-Lymphocyte", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1440256", "l": "Cells.CD14+CD11b+", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2333098", "l": "Set of cholinergic cells of diagonal gyrus [Ch2]", "d": []}]}
{"type": "biolink:Cell", "ic": "83.552982069901191", "identifiers": [{"i": "UMLS:C1513945", "l": "Neoplastic Cuboidal Cell", "d": []}, {"i": "NCIT:C42082", "l": "Neoplastic Cuboidal Cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2336229", "l": "Transitional myocyte of anterior internodal tract", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:1000288", "l": "myocyte of atrial branch of anterior internodal tract", "d": ["A muscle cell that is part of the atrial branch of anterior internodal tract."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:4030018", "l": "kidney connecting tubule principal cell", "d": ["A renal principal cell located in the connecting tubule."]}]}
{"type": "biolink:Cell", "ic": "84.75972595860604", "identifiers": [{"i": "CL:0002488", "l": "trophoblast giant cell", "d": ["A trophoblast cell that has a large volume of cytoplasm, is polyploid and is usually mononuclear but is also occasionally multi-nucleate. This cell type is important in establishing maternal physiology and remodeling of the vasculature of the placenta."]}]}
{"type": "biolink:Cell", "ic": "87.120474278337809", "identifiers": [{"i": "UMLS:C1513752", "l": "Multipolar neuron", "d": []}, {"i": "NCIT:C33143", "l": "Multipolar Neuron", "d": ["A nerve cell with several processes, usually an axon and three or more dendrites."]}]}
{"type": "biolink:Cell", "ic": "70.75272396535307", "identifiers": [{"i": "CL:0010009", "l": "camera-type eye photoreceptor cell", "d": []}]}
{"type": "biolink:Cell", "ic": "71.602448984170266", "identifiers": [{"i": "CL:0000657", "l": "secondary spermatocyte", "d": ["One of the two haploid cells into which a primary spermatocyte divides, and which in turn gives origin to spermatids."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5556533", "l": "Revakinagene Taroretcel", "d": []}, {"i": "NCIT:C180656", "l": "Revakinagene Taroretcel", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157298", "l": "CD13 cells | Blood | Cell markers", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0545577", "l": "Marrow plasma cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4301984", "l": "Non-motile spermatozoa", "d": []}, {"i": "SNOMEDCT:723203005", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:4023119", "l": "basket morphology L2/3 pvalb-like sst GABAergic cortical interneuron (Mus musculus)", "d": ["A L2/3 pvalb-like sst GABAergic cortical interneuron (Mus musculus) that has basket morphology.", "A subpopulation of amacrine cell that migrate further than other amacrine cells, and come to lie basal to the inner plexiform layer (IPL) in the ganglion cell layer. Displaced amacrine cells still have their neurites extending apically into the IPL, and therefore exhibit an inverted polarity with respect to the other amacrine cells."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002636", "l": "nonkeratinized epithelial cell of inferior part of anal canal", "d": ["A nonkeratinized cell epithleial cell of the inferior part of the anal canal."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5419548", "l": "Modified Conditionally Reprogrammed Cells", "d": []}, {"i": "NCIT:C172258", "l": "Modified Conditionally Reprogrammed Cells", "d": ["A conditionally reprogrammed cell sample comprised of non-epithelial cells isolated from a tissue sample that were rapidly expanded in monolayer culture under various cell type-specific culture conditions to promote the rapid proliferation of the cell type of interest."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5690765", "l": "Limbal Stem Cells", "d": []}, {"i": "MESH:D000093282", "l": "Limbal Stem Cells", "d": []}]}
{"type": "biolink:Cell", "ic": "92.728541327098611", "identifiers": [{"i": "CL:0002218", "l": "immature dendritic epithelial T cell precursor", "d": ["A double negative thymocyte that has a T cell receptor consisting of a gamma chain that has as part a Vgamma3 segment, and a delta chain. This cell type is CD4-negative, CD8-negative and CD24-positive. This cell-type is found in the fetal thymus with highest numbers occurring at E17-E18."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5186017", "l": "Blasts | Fetus | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4518149", "l": "Population of all spermatozoa with broken tail in portion of fluid", "d": []}, {"i": "SNOMEDCT:725253001", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1267822", "l": "CD4+ CD25+ Regulatory T Cells", "d": []}, {"i": "NCIT:C78829", "l": "CD4+ CD25+ Regulatory T Cells", "d": ["Regulatory T cells that express CD4 and CD25 (interleukin 2 receptor) antigens, with immunomodulating activity. CD4+CD25+ T regulatory cells (Tregs), a subset of CD4+ T cells expressing high levels of CD25 and the transcription factor Foxp3, are essential in maintaining immunologic homeostasis, preventing autoimmunity by suppressing self-reactive T cells; CD4+CD25+ Tregs may induce tolerance to allogeneic organ transplants such as hematopoetic stem cell transplants (HSCTs)."]}, {"i": "SNOMEDCT:115399009", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5419315", "l": "Evagenretcel", "d": []}, {"i": "NCIT:C171809", "l": "Evagenretcel", "d": []}]}
{"type": "biolink:Cell", "ic": "90.82444074280258", "identifiers": [{"i": "UMLS:C1517733", "l": "Large Megakaryocyte", "d": []}, {"i": "NCIT:C37044", "l": "Large Megakaryocyte", "d": []}]}
{"type": "biolink:Cell", "ic": "78.435418415656045", "identifiers": [{"i": "CL:4023009", "l": "extratelencephalic-projecting glutamatergic cortical neuron", "d": ["A glutamatergic neuron located in the cerebral cortex that projects to structures not derived from telencephalon."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C0029432", "l": "Osteocytes", "d": []}, {"i": "NCIT:C12569", "l": "Osteocyte", "d": ["A cell that is formed when an osteoblast becomes embedded within the bone matrix that it has secreted. Osteoclasts reside in chambers called lacunae that are found in mature bone."]}, {"i": "MESH:D010011", "l": "Osteocytes", "d": []}, {"i": "SNOMEDCT:23821005", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4505244", "l": "Suprachiasmatic Nucleus Cells", "d": []}]}
{"type": "biolink:Cell", "ic": "88.140761698499901", "identifiers": [{"i": "UMLS:C0229598", "l": "Structure of delta Cell of islet", "d": []}, {"i": "NCIT:C38639", "l": "Delta Cell of the Pancreas", "d": ["A type of cell in the pancreatic islets that secretes somatostatin."]}, {"i": "SNOMEDCT:11815004", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4543340", "l": "Spermatozoa component of semen", "d": []}, {"i": "SNOMEDCT:734848001", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5419239", "l": "Avoplacel", "d": []}, {"i": "NCIT:C171652", "l": "Avoplacel", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4324141", "l": "Wasserhelle cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0007601", "l": "Cell Line, Transformed", "d": []}, {"i": "MESH:D002461", "l": "Cell Line, Transformed", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1267892", "l": "Lymphocyte positive for CD22 antigen", "d": []}, {"i": "SNOMEDCT:116819008", "d": []}]}
{"type": "biolink:Cell", "ic": "92.728541327098611", "identifiers": [{"i": "CL:0000581", "l": "peritoneal macrophage", "d": ["A macrophage resident in the peritoneum under non-inflammatory conditions. Markers include F4/80-high, CD11b-high, CD68-positive, SIGNR1-positive, CD115-high, MHC-II-negative, and Dectin-1-positive."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002455", "l": "CD8_alpha-negative plasmacytoid dendritic cell", "d": ["A CD11c-low plasmacytoid dendritic cell that is CD8alpha-negative and CD4-positive."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2339502", "l": "Enterocyte of epithelium proper of jejunum", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0003029", "l": "M2 retinal ganglion cell", "d": ["A monostratified retinal ganglion cell that has a small soma, a small dendrite field with a dense dendrite arbor, and post synaptic terminals in sublaminer layer S2 and S3."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4324117", "l": "CD77+ B lymphocyte", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1267814", "l": "Lymphocyte positive for CD2 antigen and CD20 antigen", "d": []}, {"i": "SNOMEDCT:117517007", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0009040", "l": "stromal cell of lamina propria of colon", "d": ["A stromal cell found in the lamina propria of the colon."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C4724851", "l": "Allogeneic TCR alpha/beta-positive T-lymphocyte-depleted Peripheral Blood Stem Cells", "d": []}, {"i": "NCIT:C148149", "l": "Allogeneic TCR alpha/beta-positive T-lymphocyte-depleted Peripheral Blood Stem Cells", "d": ["A preparation of allogeneic T-cell receptor (TCR) alpha/beta-positive T cell-depleted peripheral blood stem cells (PBSCs), that can potentially be used for hematopoietic stem cell transplantation (HSCT). Allogeneic PBMCs are processed, using the proprietary CliniMACS device, to remove TCRalpha/beta T-cells, while retaining other cells, such as donor-derived natural killer (NK) cells and gamma/delta T-cells. As TCR alpha/beta-positive T-cells appear to be related to the development of graft versus host disease (GvHD), depletion of these cells may lower the risk of the recipient developing GvHD. Upon infusion of the TCR alpha/beta-positive T-cell-depleted PBSCs for allogeneic stem cell transplantation (allo SCT), the alpha/beta-positive T-cell depletion as well as the presence of allogeneic NK cells, and other cells, may facilitate engraftment, exert graft-versus-leukemia effects, enhance post-transplant immune recovery, and reduce the risk of infections and GvHD."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1979162", "l": "Blasts.CD15", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5173436", "l": "Monocytes | Peritoneal fluid | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "ic": "87.120474278337809", "identifiers": [{"i": "CL:0000961", "l": "Bm1 B cell", "d": ["A follicular B cell that is IgD-positive, CD23-negative, and CD38-negative. This naive cell type is activated in the extrafollicular areas through interaction with interdigitating dendritic cells and antigen-specific CD4-positive T cells."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1511447", "l": "Mouse Undifferentiated Brain Cell", "d": []}, {"i": "NCIT:C22624", "l": "Mouse Undifferentiated Brain Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5557404", "l": "Anti-CLDN18.2 CAR T Cells LY011", "d": []}, {"i": "NCIT:C181995", "l": "Anti-CLDN18.2 CAR T Cells LY011", "d": ["A preparation of allogeneic T-lymphocytes that have been genetically modified to express a chimeric antigen receptor (CAR) targeting the tumor-associated antigen (TAA) Claudin18.2 (CLDN18.2; A2 isoform of claudin-18), with potential immunostimulating and antineoplastic activities. Upon administration, the anti-CLDN18.2 CAR T-cells LY011 specifically recognize and bind to CLDN18.2-expressing tumor cells. This may result in a specific cytotoxic T-lymphocyte (CTL)-mediated killing of CLDN18.2-expressing tumor cells. CLDN18.2, a tight junction protein and stomach-specific isoform of claudin-18, is overexpressed on a variety of tumor cells, but its expression in healthy tissues is strictly confined to short-lived differentiated epithelial cells of the gastric mucosa."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5170471", "l": "Large granular lymphocytes | Blood | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "ic": "89.347505587204751", "identifiers": [{"i": "CL:1001138", "l": "interlobular artery cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1440416", "l": "Cells.t(9;11)(p22;q23)(MLLT3,MLL)", "d": []}]}
{"type": "biolink:Cell", "ic": "92.728541327098611", "identifiers": [{"i": "CL:0001078", "l": "group 3 innate lymphoid cell, human", "d": ["A group 3 innate lymphoid cell in the human with the phenotype IL-7Ralpha-positive."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0444088", "l": "Tissue cell sample", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0020200", "l": "Hybrid Cells", "d": []}, {"i": "MESH:D006822", "l": "Hybrid Cells", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157351", "l": "CD19+CD25+ cells | Blood | Cell markers", "d": []}]}
{"type": "biolink:Cell", "ic": "92.728541327098611", "identifiers": [{"i": "CL:0000091", "l": "Kupffer cell", "d": ["A tissue-resident macrophage of the reticuloendothelial system found on the luminal surface of the hepatic sinusoids involved in erythrocyte clearance. Markers include F4/80+, CD11b-low, CD68-positive, sialoadhesin-positive, CD163/SRCR-positive. Irregular, with long processes including lamellipodia extending into the sinusoid lumen, have flattened nucleus with cytoplasm containing characteristic invaginations of the plasma membrane (vermiform bodies); lie within the sinusoid lumen attached to the endothelial surface; derived from the bone marrow, form a major part of the body's mononuclear phagocyte system."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5544464", "l": "Immunological Memory Cells", "d": []}, {"i": "MESH:D000091244", "l": "Immunological Memory Cells", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5173441", "l": "Monocytes.abnormal/100 leukocytes | Blood | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0001048", "l": "activated CD4-positive, CD25-positive, CCR4-positive, alpha-beta regulatory T cell, human", "d": ["A CD4-positive, CD25-positive, CCR4-positive, alpha-beta T regulatory cell with the phenotype HLA-DRA-positive, indicating recent activation."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2736938", "l": "Cells.CD8+CD45RO+", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5708041", "l": "Anti-GD2/Anti-CD56 4SCAR-expressing Bispecific T-cells", "d": []}, {"i": "NCIT:C188801", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5171751", "l": "Lymphocytes+Monocytes/100 leukocytes | Blood | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "ic": "87.120474278337809", "identifiers": [{"i": "UMLS:C1706981", "l": "Bone Marrow Stem Cell with Potential to Differentiate to Granulocytic Lineage", "d": []}, {"i": "NCIT:C42716", "l": "Bone Marrow Stem Cell with Potential to Differentiate to Granulocytic Lineage", "d": ["A primitive, undifferentiated blood cell which can undergo division and give rise to white blood cells in the neutrophil, eosinophil or basophil lines."]}]}
{"type": "biolink:Cell", "ic": "92.728541327098611", "identifiers": [{"i": "CL:0009014", "l": "Peyer's patch lymphocyte", "d": ["A lymphocyte that is part of a Peyer's patch. These cells have a major role in driving the immune response to antigens sampled from the intestinal lumen, and in regulating the formation of follicle-associated epithelium and M cells in Peyer's patches by converting intestitial enterocytes into M cells."]}]}
{"type": "biolink:Cell", "ic": "69.453592996529309", "identifiers": [{"i": "UMLS:C1510730", "l": "Abnormal Mesothelial Cell", "d": []}, {"i": "NCIT:C36829", "l": "Abnormal Mesothelial Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "90.82444074280258", "identifiers": [{"i": "CL:0000440", "l": "melanocyte stimulating hormone secreting cell", "d": ["A cell of the intermediate pituitary that produces melanocyte stimulating hormone."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5170947", "l": "Leukocytes | XXX | Cell markers", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0546500", "l": "P.B. megakaryoblast", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5216321", "l": "Unidentified cells|NCnc|Pt|CSF", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C2826155", "l": "2G-1 TCR Retroviral Vector-Transduced Lymphocytes", "d": []}, {"i": "NCIT:C82408", "l": "2G-1 TCR Retroviral Vector-Transduced Lymphocytes", "d": ["A preparation of autologous human T-lymphocytes isolated from renal cell cancer (RCC) patient and transduced with 2G-1 TCR, a retroviral vector encoding the alpha and beta chains of a T-cell receptor that recognizes TNF-related apoptosis inducing ligand (TRAIL) bound to death receptor 4 (DR4), with potential immunostimulating and antineoplastic activities. After transduction, expansion in culture, and introduction into the RCC patient, 2G-1 TCR retroviral vector-transduced lymphocytes may stimulate a cytotoxic T lymphocyte (CTL) response against RCC cells with TRAIL bound to DR4 on their surfaces. TRAIL, a member of the TNF superfamily, is a homotrimeric type II membrane protein that rapidly induces oligomerization of receptor intracellular death domains and apoptosis in a variety of tumor cells when bound to its receptors; DR4 (TRAIL receptor 1), a member of the TNF receptor family, is overexpressed by a variety of malignant cell types."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5426724", "l": "100 Cells.CD3-CD14-CD45+CD56+", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C2984032", "l": "Anti-HER2-CAR Autologous CMV-Specific Cytotoxic T-Lymphocytes", "d": []}, {"i": "NCIT:C91091", "l": "Anti-HER2-CAR Autologous CMV-Specific Cytotoxic T-Lymphocytes", "d": ["Autologous human cytomegalovirus (CMV)-specific human cytotoxic T-lymphocytes (CTLs) transduced with a retroviral vector encoding a human anti-Her-2 (epidermal growth factor receptor 2) chimeric T cell receptor (CAR) gene with potential immunostimulatory and antineoplastic activities. Autologous CTLs from a patient with Her-2- and CMV-positive glioblastoma multiforme (GBM) are genetically modified to express CAR gene specific for Her-2 on their cell surfaces. After expansion in culture and reintroduction into the patient, the anti-HER2-CAR autologous CMV-specific CTLs bind to Her-2 antigen on tumor cell surfaces; subsequently, Her-2-positive tumor cells and stem cells may be lysed. Her-2 (ErbB-2), a receptor tyrosine kinase (RTK) overexpressed by a variety of cancer cell types, plays key roles in tumor cell proliferation and tumor angiogenesis. CMV is present in the majority of GBM tumors."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5446552", "l": "Autologous Bispecific BCMA/CD19-targeted CAR-T Cells GC012F", "d": []}, {"i": "NCIT:C175471", "l": "Autologous Bispecific BCMA/CD19-targeted CAR-T Cells GC012F", "d": ["A preparation of autologous T-lymphocytes engineered to express two separate chimeric antigen receptors (CARs) targeting the tumor-associated antigens (TAAs) BCMA and CD19 and fused to as of yet not fully elucidated co-stimulatory domains, with potential immunostimulating and antineoplastic activities. Upon administration, the autologous bispecific BCMA/CD19-targeted CAR-T cells GC012F specifically and simultaneously target and bind to tumor cells expressing BCMA and/or CD19. This induces selective toxicity in tumor cells that express BCMA and/or CD19. BCMA, a tumor-specific antigen and a receptor for both a proliferation-inducing ligand (APRIL) and B-cell activating factor (BAFF), is a member of the tumor necrosis factor receptor superfamily (TNFRSF) and plays a key role in the survival of B-lymphocytes and plasma cells. BCMA is found on the surfaces of B-cells and is overexpressed on malignant plasma cells. CD19 is a B-cell-specific cell surface antigen overexpressed in B-cell lineage malignancies. The processing platform used, FasT CAR-T, shortens the manufacturing time to produce the CAR-T cells within 24 hours."]}]}
{"type": "biolink:Cell", "ic": "70.75272396535307", "identifiers": [{"i": "UMLS:C1881589", "l": "Malignant Round Germ Cell", "d": []}, {"i": "NCIT:C61387", "l": "Malignant Round Germ Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "37.0727135123377", "identifiers": [{"i": "UMLS:C0431085", "l": "Tumor cells, uncertain whether benign or malignant", "d": []}, {"i": "NCIT:C12922", "l": "Neoplastic Cell", "d": ["Cells of, or derived from, a tumor."]}, {"i": "SNOMEDCT:39577004", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0333822", "l": "Microlymphoblast", "d": []}, {"i": "SNOMEDCT:2014001", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5184396", "l": "Unidentified cells | Body fluid | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "CL:0002527", "l": "immature CD14-positive dermal dendritic cell", "d": ["An immature CD14-positive dermal dendritic cell is CD80-low, CD86-low, and MHCII-low."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0282480", "l": "Muscle Fibers, White", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157382", "l": "CD20+CD25+ cells | Blood | Cell markers", "d": []}]}
{"type": "biolink:Cell", "ic": "90.82444074280258", "identifiers": [{"i": "UMLS:C1514114", "l": "Neoplastic Thyrotroph Cell", "d": []}, {"i": "NCIT:C36922", "l": "Neoplastic Thyrotroph Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1513972", "l": "Neoplastic Germ Cell with Clear to Lightly Eosinophilic Cytoplasm", "d": []}, {"i": "NCIT:C37130", "l": "Neoplastic Germ Cell with Clear to Lightly Eosinophilic Cytoplasm", "d": []}]}
{"type": "biolink:Cell", "ic": "90.82444074280258", "identifiers": [{"i": "CL:0002275", "l": "pancreatic PP cell", "d": ["A PP cell located in the islets of the pancreas."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157444", "l": "CD3+CD4+CD45RO+ cells | Blood | Cell markers", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1956051", "l": "Hair Cells, Ampulla", "d": []}, {"i": "MESH:D054777", "l": "Hair Cells, Ampulla", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1440298", "l": "Cells.CD34+DR+", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C4329326", "l": "Anti-Glypican 3-scFvGC33-CAR-expressing T Lymphocytes", "d": []}, {"i": "NCIT:C132989", "l": "Anti-Glypican 3-scFvGC33-CAR-expressing T Lymphocytes", "d": ["A preparation of autologous T-lymphocytes that have been genetically modified to express a chimeric antigen receptor (CAR) containing a single chain variable fragment (scFv) derived from the anti-glypican-3 (GPC3) monoclonal antibody GC33 (scFvGC33), with potential immunostimulating and antineoplastic activities. Upon administration, anti-GPC3-scFvGC33-CAR autologous T-lymphocytes specifically target and bind to GPC3-expressing tumor cells, resulting in tumor cell lysis. GPC3, a heparan sulfate proteoglycan and a member of the glypican family, is overexpressed on certain tumor cell types while minimally expressed in normal, healthy cells.. GPC3 plays an important role in cellular proliferation and differentiation."]}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "CL:1000182", "l": "malpighian tubule tip cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1267910", "l": "Lymphocyte positive for CD34 antigen", "d": []}, {"i": "SNOMEDCT:116733003", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0000251", "l": "extramedullary cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2333238", "l": "Microfold cell of epithelium proper of jejunum", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5163235", "l": "Elliptocytes | Blood | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "ic": "71.335885432862128", "identifiers": [{"i": "UMLS:C1513974", "l": "Neoplastic Glandular Cell with Clear Cytoplasm", "d": []}, {"i": "NCIT:C36765", "l": "Neoplastic Glandular Cell with Clear Cytoplasm", "d": []}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "UMLS:C1513990", "l": "Neoplastic Immunoblast-Like B-Lymphocyte", "d": []}, {"i": "NCIT:C38657", "l": "Neoplastic Immunoblast-Like B-Lymphocyte", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2327673", "l": "Rod bipolar cell", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:1001573", "l": "nasopharyngeal epithelial cell", "d": ["Cell of the nasopharyngeal epithelium."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0009071", "l": "medullary thymic epithelial cell type 1", "d": ["A thymic medullary epithelial cell considered to be a pre-AIRE mTEC population."]}]}
{"type": "biolink:Cell", "ic": "62.994560329557565", "identifiers": [{"i": "CL:4030029", "l": "blood lymphocyte", "d": ["A lymphocyte located in blood."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5184818", "l": "Variant lymphocytes | Blood | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "UMLS:C1514041", "l": "Neoplastic Myoid Cell", "d": []}, {"i": "NCIT:C36964", "l": "Neoplastic Myoid Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "82.532694649739099", "identifiers": [{"i": "UMLS:C1514050", "l": "Neoplastic Neutrophilic Precursor", "d": []}, {"i": "NCIT:C37076", "l": "Neoplastic Neutrophilic Precursor", "d": []}]}
{"type": "biolink:Cell", "ic": "87.120474278337809", "identifiers": [{"i": "CL:0000487", "l": "oenocyte", "d": ["A secretory cell of ectodermal origin. This cell may have important functions in fatty acid and hydrocarbon metabolism and is metabolically linked to the fat body and tracheae. This cell is exclusive of arthropods."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1512337", "l": "HeLa/SF", "d": []}, {"i": "NCIT:C20228", "l": "HeLa/SF", "d": ["HeLa/SF is a derivative of HeLa adapted to grow in serum free medium. Over time, the serum component of the medium was replaced with TCH, a defined multipurpose serum replacement."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1440238", "l": "Cell positive for CD106 antigen", "d": []}, {"i": "SNOMEDCT:725718007", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157548", "l": "CD4+CD45RA+CD45RB+CD45RC+ cells | Tissue and Smears | Cell markers", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2340402", "l": "Intrafascicular oligodendrocyte", "d": []}]}
{"type": "biolink:Cell", "ic": "81.648881485605159", "identifiers": [{"i": "UMLS:C1518846", "l": "Paget Cell", "d": []}, {"i": "NCIT:C36754", "l": "Paget Cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1979644", "l": "Blasts.CD30", "d": []}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "UMLS:C1711353", "l": "Malignant Large Hyperchromatic Fibrohistiocytic Cell", "d": []}, {"i": "NCIT:C49074", "l": "Malignant Large Hyperchromatic Fibrohistiocytic Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "90.82444074280258", "identifiers": [{"i": "UMLS:C1708646", "l": "Large Malignant Histiocyte", "d": []}, {"i": "NCIT:C43255", "l": "Large Malignant Histiocyte", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5184822", "l": "Variant lymphocytes | Peritoneal fluid | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "ic": "90.82444074280258", "identifiers": [{"i": "CL:0000796", "l": "CD8-alpha-beta-positive, alpha-beta intraepithelial T cell", "d": ["A alpha-beta intraepithelial T cell found in the columnar epithelium of the gastrointestinal tract. Intraepithelial T cells often have distinct developmental pathways and activation requirements."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1520027", "l": "Preganglionic neuron", "d": []}, {"i": "NCIT:C33878", "l": "Visceral Efferent Neuron", "d": ["A cell that conducts a nerve impulse that originated in the central nervous system and proceeds towards one of the interior organs of the one of the three cavities of the body."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1183200", "l": "Set of adrenergic cells in area postrema and anterior reticular nucleus [C1, C2]", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1254549", "l": "Stippled Erythrocyte", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0009114", "l": "monocytoid B cell", "d": ["A B cell found in the perisinusoidal area of a lymph node. In humans, monocytoid B cells are a morphologically distinct B cell population"]}]}
{"type": "biolink:Cell", "ic": "92.728541327098611", "identifiers": [{"i": "CL:0004138", "l": "retinal ganglion cell A2", "d": ["A retinal ganglion A cell with dense arbor near soma."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:4023066", "l": "horizontal pyramidal neuron", "d": ["A pyramidal neuron which has an apical tree which is oriented parallel to the pia. This is unlike typical pyramidal neurons which have its apical dendrite aligned vertically."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:1000698", "l": "kidney resident macrophage", "d": ["A tissue-resident macrophage that is part of some kidney."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157597", "l": "CD5+CD2- | White blood cells | Cell markers", "d": []}]}
{"type": "biolink:Cell", "ic": "87.120474278337809", "identifiers": [{"i": "UMLS:C1513172", "l": "Metaplastic Epithelial Cell", "d": []}, {"i": "NCIT:C36816", "l": "Metaplastic Epithelial Cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4510917", "l": "Blast cell with terminal deoxyribonucleotidyl transferase", "d": []}, {"i": "SNOMEDCT:724317009", "d": []}]}
{"type": "biolink:Cell", "ic": "87.120474278337809", "identifiers": [{"i": "UMLS:C0030281", "l": "Structure of beta Cell of islet", "d": []}, {"i": "NCIT:C32199", "l": "Beta Cell", "d": ["A cell that composes the bulk of the islets of Langerhans and secretes insulin."]}, {"i": "MESH:D050417", "l": "Insulin-Secreting Cells", "d": []}, {"i": "SNOMEDCT:36565008", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0947286", "l": "Cell positive for CD14 antigen", "d": []}, {"i": "SNOMEDCT:116752009", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002273", "l": "type ECL enteroendocrine cell", "d": ["A type EC enteroendocrine cell type that is numerous in the fundus of the stomach; stores 5-hydroxytryptamine and histamine."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5175148", "l": "Nucleated cells | Bronchial | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C3495992", "l": "C3 adrenaline cells", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C4085965", "l": "Anti-CD3/Anti-EGFR-bispecific Monoclonal Antibody-armed Activated Autologous T-lymphocytes", "d": []}, {"i": "NCIT:C125185", "l": "Anti-CD3/Anti-EGFR-bispecific Monoclonal Antibody-armed Activated Autologous T-lymphocytes", "d": ["Autologous activated T-cells that have been coated with bispecific antibodies (BiAb) comprised of an anti-CD3 monoclonal antibody heteroconjugated to an anti-epidermal growth factor receptor (EGFR) monoclonal antibody, with potential antineoplastic and immunomodulating activities. Upon administration, anti-CD3 x anti-EGFR bispecific antibody-armed activated T-cells (AATC) attach to and selectively cross-link CD3-expressing T-cells and EGFR-expressing tumor cells. This results in the activation of cytotoxic T-lymphocytes (CTLs) and selective cytotoxicity towards the EGFR-expressing tumor cells. In addition, cytokine and chemokine secretion by the T-cells further activates the immune system, which leads to the recruitment and activation of CTLs, and additional CTL-mediated tumor-specific cell lysis. CD3 is part of the functional T-cell receptor (TCR) complex, which is necessary for antigen recognition by T-cells, and is required for signal transduction. EGFR, a receptor tyrosine kinase, is overexpressed on the surfaces of various tumor cell types."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4515377", "l": "Entire endocrine pancreas cell", "d": []}, {"i": "SNOMEDCT:730209004", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1182804", "l": "Epithelial cell of endocrine pancreas", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1257774", "l": "Granulocyte Precursor Cells", "d": []}, {"i": "MESH:D042381", "l": "Granulocyte Precursor Cells", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C4744827", "l": "Derived Cell Line", "d": []}, {"i": "NCIT:C156445", "l": "Derived Cell Line", "d": ["A biospecimen generated by in vitro culturing of a single cell isolated from a tissue of interest."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1444185", "l": "Cleidoic ovum part", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5446421", "l": "ET140203", "d": []}, {"i": "NCIT:C175306", "l": "Autologous TCRm-expressing T-cells ET140203", "d": ["A preparation of autologous T-lymphocytes that have been transduced with a lentiviral vector to express a T-cell receptor mimetic (TCRm) construct targeting as of yet undisclosed tumor associated antigen(s) (TAA), with potential immunomodulatory and antineoplastic activities. Upon administration, the autologous TCRm-expressing T-cells ET140203 specifically recognize and selectively bind to the as of yet undisclosed TAA(s). This results in cytotoxic T-lymphocyte (CTL)-mediated killing of tumor cells expressing the TAA(s)."]}]}
{"type": "biolink:Cell", "ic": "84.128890093485552", "identifiers": [{"i": "UMLS:C1514075", "l": "Neoplastic Promyelocyte", "d": []}, {"i": "NCIT:C37072", "l": "Neoplastic Promyelocyte", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0039198", "l": "Regulatory T-Lymphocytes", "d": []}, {"i": "MESH:D050378", "l": "T-Lymphocytes, Regulatory", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5168981", "l": "Immature lymphocytes | Blood | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5171663", "l": "Lymphocytes | Pericardial fluid | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "ic": "92.728541327098611", "identifiers": [{"i": "CL:0000347", "l": "scleral cell", "d": ["A cell of the sclera of the eye."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5151403", "l": "Acanthocytes | Blood | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2603381", "l": "CD135 cells", "d": []}]}
{"type": "biolink:Cell", "ic": "77.712653754434029", "identifiers": [{"i": "CL:0000604", "l": "retinal rod cell", "d": ["One of the two photoreceptor cell types of the vertebrate retina. In rods the photopigment is in stacks of membranous disks separate from the outer cell membrane. Rods are more sensitive to light than cones, but rod mediated vision has less spatial and temporal resolution than cone vision."]}]}
{"type": "biolink:Cell", "ic": "82.076046914303362", "identifiers": [{"i": "UMLS:C5555134", "l": "Neoplastic Vacuolated Cell", "d": []}, {"i": "NCIT:C178561", "l": "Neoplastic Vacuolated Cell", "d": ["A neoplastic cell characterized by the presence of cytoplasmic vacuoles."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5761852", "l": "GPRC5D-CAR-T", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0301868", "l": "Committed cell", "d": []}, {"i": "SNOMEDCT:55484008", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5417937", "l": "Allogeneic EBV/CMV/AdV/HHV6/BKV/JCV-specific CTLs ALVR105", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1267957", "l": "Lymphocyte positive for CD64 antigen", "d": []}, {"i": "SNOMEDCT:117398002", "d": []}]}
{"type": "biolink:Cell", "ic": "82.076046914303362", "identifiers": [{"i": "CL:0000137", "l": "osteocyte", "d": ["A mature osteoblast that has become embedded in the bone matrix. They occupy a small cavity, called lacuna, in the matrix and are connected to adjacent osteocytes via protoplasmic projections called canaliculi."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002322", "l": "embryonic stem cell", "d": ["A stem cell of embryonic origin."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0000140", "l": "odontocyte", "d": ["Skeletogenic cell that secretes dentine matrix, is derived from odontogenic papilla. Embedded in dentine tissue, and is the transformation of a non-terminally differentiated odontoblast cell."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0596108", "l": "antibody dependent killer cell", "d": []}]}
{"type": "biolink:Cell", "ic": "72.269651791985453", "identifiers": [{"i": "UMLS:C1514095", "l": "Neoplastic Small to Medium-Sized Lymphocyte", "d": []}, {"i": "NCIT:C36990", "l": "Neoplastic Small to Medium-Sized Lymphocyte", "d": []}]}
{"type": "biolink:Cell", "ic": "90.82444074280258", "identifiers": [{"i": "CL:0019003", "l": "tracheobronchial goblet cell", "d": ["Any goblet cell that is part of the tracheobronchial epithelium."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1455886", "l": "Atypical Endocervical Cell", "d": []}, {"i": "NCIT:C141518", "l": "Atypical Endocervical Cell", "d": ["An abnormal endocervical cell found in a cervical smear. It may be related to an inflammatory or neoplastic process."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4687977", "l": "Orvacabtagene autoleucel", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1513952", "l": "Neoplastic Endocrine Chief Cell", "d": []}, {"i": "NCIT:C36938", "l": "Neoplastic Endocrine Chief Cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0229214", "l": "Cone cells of inner nuclear layer", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C2699753", "l": "TGF-beta-Resistant LMP-Specific Cytotoxic T-Lymphocytes", "d": []}, {"i": "NCIT:C77859", "l": "TGF-beta-Resistant LMP-Specific Cytotoxic T-Lymphocytes", "d": ["A preparation of transforming growth factor-beta (TGF-beta)-resistant cytotoxic T-lymphocytes (CTL) reactive to Epstein-Barr virus (EBV) latent membrane proteins 1 and 2 (LMP 1 and 2) with potential antineoplastic activity. T lymphocytes are transduced with a retroviral vector expressing the dominant-negative mutant type II TGF-beta receptor, which blocks signaling by all three TGF-beta isoforms. These TGF-beta-resistant T-lymphocytes are exposed ex-vivo to dendritic cells (DCs) transfected with a replication-deficient adenovirus encoding EBV LMP; subsequent exposure to LMP1- or LMP2-expressing lymphoblastoid cell lines is used to expand the CTL.  Administered to patients with EBV-positive tumors, TGF-beta-resistant LMP-specific CTL target LMP-positive cells, which may result in a specific CTL response, followed by cell lysis and inhibition of tumor cell proliferation. Tumor-expressed TGF-beta inhibits T lymphocyte activation and expansion."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2339015", "l": "Vacuolar absorptive cell of epithelium proper of large intestine", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5163540", "l": "Epithelial cells | Semen | Fertility testing", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1440290", "l": "Cells.CD3+CD8+CD45RO-CD45RA+", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1512899", "l": "Interphase Cell", "d": []}, {"i": "NCIT:C32869", "l": "Interphase Cell", "d": ["A cell in a resting state. Individual chromosomes are not visible. The cell performs all biochemical and physiologic functions and replication of chromatin occurs."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0228078", "l": "Partly differentiated neural cell", "d": []}, {"i": "SNOMEDCT:71609000", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2951544", "l": "Type D enteroendocrine cell of epithelium proper of jejunum", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4484257", "l": "100 cells.CD8", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1267849", "l": "Lymphocyte positive for both CD5 antigen and CD8 antigen", "d": []}, {"i": "SNOMEDCT:117535003", "d": []}]}
{"type": "biolink:Cell", "ic": "67.782924002860781", "identifiers": [{"i": "UMLS:C1513960", "l": "Neoplastic Epithelial Clear Cell", "d": []}, {"i": "NCIT:C36756", "l": "Neoplastic Epithelial Clear Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0009051", "l": "T cell of anorectum", "d": ["A T cell that is located in the anorectum."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2339119", "l": "Basal cell of epithelium of lobular bronchiole", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5555871", "l": "Natural Killer Cells KDS-1001", "d": []}, {"i": "NCIT:C179715", "l": "Natural Killer Cells KDS-1001", "d": ["A preparation of natural killer (NK) cells, with potential cytolytic and antineoplastic activities. Upon infusion, the NK cells KDS-1001 may lyse cancer cells."]}]}
{"type": "biolink:Cell", "ic": "78.695011174409487", "identifiers": [{"i": "CL:0000502", "l": "type D enteroendocrine cell", "d": ["A cell found throughout the gastrointestinal tract and in the pancreas. They secrete somatostatin in both an endocrine and paracrine manner. Somatostatin inhibits gastrin, cholecystokinin, insulin, glucagon, pancreatic enzymes, and gastric hydrochloric acid. A variety of substances which inhibit gastric acid secretion (vasoactive intestinal peptide, calcitonin gene-related peptide, cholecystokinin, beta-adrenergic agonists, and gastric inhibitory peptide) are thought to act by releasing somatostatin."]}]}
{"type": "biolink:Cell", "ic": "84.128890093485552", "identifiers": [{"i": "UMLS:C0036770", "l": "Structure of sertoli cell", "d": []}, {"i": "NCIT:C12595", "l": "Sertoli Cell", "d": ["Elongated cells in the seminiferous tubules to which spermatids are attached during spermiogenesis; they secrete androgen-binding protein and establish the blood-testis barrier by forming tight junctions with adjacent Sertoli's cells."]}, {"i": "MESH:D012708", "l": "Sertoli Cells", "d": []}, {"i": "SNOMEDCT:40281007", "d": []}]}
{"type": "biolink:Cell", "ic": "92.728541327098611", "identifiers": [{"i": "UMLS:C1711380", "l": "Neoplastic Medium to Large Size Erythroblast", "d": []}, {"i": "NCIT:C43218", "l": "Neoplastic Medium to Large Size Erythroblast", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1708859", "l": "Malignant Acantholytic Squamous Cell", "d": []}, {"i": "NCIT:C54236", "l": "Malignant Acantholytic Squamous Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "88.140761698499901", "identifiers": [{"i": "CL:0000512", "l": "paracrine cell", "d": ["A paracrine cell is a secretory cell that secretes an agonist into intercellular spaces in which it diffuses to a target cell other than that which produced it."]}]}
{"type": "biolink:Cell", "ic": "75.105493098994543", "identifiers": [{"i": "UMLS:C1510727", "l": "Abnormal Intermediate Type Trophoblastic Cell", "d": []}, {"i": "NCIT:C36802", "l": "Abnormal Intermediate Type Trophoblastic Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1517354", "l": "GE01 cell line", "d": []}, {"i": "NCIT:C20256", "l": "GE01", "d": ["Provider: Geron Corporation, Menlo Park, CA. No information from provider. This cell line meets the criteria for the use of human embryonic stem cells by federally funded researchers."]}]}
{"type": "biolink:Cell", "ic": "78.695011174409487", "identifiers": [{"i": "UMLS:C1514070", "l": "Neoplastic Polygonal Cell with Eosinophilic Cytoplasm", "d": []}, {"i": "NCIT:C37164", "l": "Neoplastic Polygonal Cell with Eosinophilic Cytoplasm", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5706479", "l": "Anti-FOLR1 CoStAR-expressing Autologous Tumor-infiltrating Lymphocytes ITIL-306", "d": []}, {"i": "NCIT:C188248", "l": "Anti-FOLR1 CoStAR-expressing Autologous Tumor-infiltrating Lymphocytes ITIL-306", "d": ["A preparation of autologous tumor infiltrating lymphocytes (TILs) genetically engineered to express a co-stimulatory antigen receptor (CoStAR) specific for folate receptor alpha (FolRa; FOLR1) and linked to the co-stimulatory domains CD28 and CD40, with potential immunomodulating and antineoplastic activities. Upon administration, the anti-FOLR1 CoStAR-expressing autologous TILs ITIL-306 specifically target, bind to and kill the FOLR1-expressing tumor cells. In addition, ITIL-306, by binding to FOLR1, is able to activate the TILs through the costimulatory signals. This increases T-cell proliferation and activation in the tumor microenvironment (TME), thereby enhancing the T-cell-mediated anti-tumor immune response against the FOLR1-expressing tumor cells. FOLR1 is a glycosylphosphatidylinositol linked cell-surface glycoprotein that is widely expressed in certain cancers while its expression is limited in normal tissues. CoStAR provides synthetic costimulation in the TME and increases T-cell proliferation and survival, and improves the effector function of T-cells, which may boost the efficacy of TILs."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1704336", "l": "Skeletal Myocytes", "d": []}, {"i": "NCIT:C13000", "l": "Rhabdomyocyte", "d": ["A large cylindrical- or prismatic-shaped cell that is the basic unit of striated muscle tissue."]}, {"i": "NCIT:C33558", "l": "Skeletal Fiber", "d": ["A long, cylindrical, multinucleated cell comprising a network of myofibrils, which contain several proteins that compose the contractile unit of skeletal muscle, of which there are three basic types: intermediate, red, and white."]}, {"i": "NCIT:C48687", "l": "Skeletal Muscle Cell", "d": []}, {"i": "MESH:D018485", "l": "Muscle Fibers, Skeletal", "d": []}, {"i": "SNOMEDCT:80985008", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5206808", "l": "CD3+/CD19+ Cell-depleted Unrelated or Partially Matched Donor-derived Allogeneic Peripheral Blood Stem Cells", "d": []}, {"i": "NCIT:C162765", "l": "CD3+/CD19+ Cell-depleted Unrelated or Partially Matched Donor-derived Allogeneic Peripheral Blood Stem Cells", "d": ["A preparation of allogeneic peripheral blood stem cells (PBSCs) from an unrelated or partially matched related donor that have been selectively depleted of CD3-positive  (CD3+) T-cells and CD19-positive (CD19+) B-cells via leukapheresis with potential immune reconstituting activity. The CD3+/CD19+ cell-depleted PBSCs are used for allogeneic hematopoietic cell transplantation (HCT) and may allow for rapid and sustained engraftment, immune reconstitution, and may prevent or reduce graft-versus-host disease (GvHD) and Epstein-Barr virus (EBV)-driven post-transplant lymphoproliferative disorders."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4740211", "l": "Erythrocytes.CD59 complete loss", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5235892", "l": "Bone Marrow-Derived Fibroblasts", "d": []}, {"i": "NCIT:C164010", "l": "Bone Marrow-Derived Fibroblasts", "d": ["A biological sample containing fibroblasts isolated from the bone marrow of an experimental subject."]}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "CL:0002019", "l": "Ly-76 high reticulocyte", "d": ["A reticulocyte that is Ly76-high and is Kit-negative."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5159803", "l": "Chronic leukemia markers | XXX | Cell markers", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0024265", "l": "Null cell", "d": []}, {"i": "MESH:D008215", "l": "Lymphocytes, Null", "d": []}, {"i": "SNOMEDCT:54991005", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1516944", "l": "Epithelial Reticular Cell", "d": []}, {"i": "NCIT:C13124", "l": "Epithelial Reticular Cell", "d": ["A branched epithelial cell that supports epithelial structures."]}]}
{"type": "biolink:Cell", "ic": "92.728541327098611", "identifiers": [{"i": "UMLS:C1511245", "l": "Bone Marrow Stem Cell with Predominant Neutrophil Differentiation", "d": []}, {"i": "NCIT:C41060", "l": "Bone Marrow Stem Cell with Predominant Neutrophil Differentiation", "d": ["A primitive, undifferentiated blood cell which can undergo division and usually gives rise to a white blood cell in the neutrophil lineage."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002585", "l": "retinal blood vessel endothelial cell", "d": ["A blood vessel endothelial cell that is part of the retina."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1511043", "l": "Balloon Epithelial Cell", "d": []}, {"i": "NCIT:C36751", "l": "Balloon Epithelial Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1512865", "l": "Intermediate Type Trophoblastic Cell", "d": []}, {"i": "NCIT:C33920", "l": "Intermediate Type Trophoblastic Cell", "d": ["A trophoblast that travels into the junctional zone of the decidua, reacting with maternal tissue leukocytes, mainly NK cells, macrophages and T cells, and invades maternal blood vessels feeding the placenta, softening the walls and replacing the lining with fetal tissue.  This junctional zone extends at the edge of the placenta to the amino-chorionic membranes where the chorionic laeve trophoblast has intimate contact with decidua tissue.  One of the primary functions of this cell is in implantation and in the establishment of the uteroplacental circulation since it extensively invades the spiral arteries at the placental site."]}]}
{"type": "biolink:Cell", "ic": "62.495242488514975", "identifiers": [{"i": "UMLS:C0225336", "l": "Endothelial Cells", "d": []}, {"i": "NCIT:C12865", "l": "Endothelial Cell", "d": ["The main type of cell forming the lining of blood and lymph vessels and the inner layer of the endocardium."]}, {"i": "MESH:D042783", "l": "Endothelial Cells", "d": []}, {"i": "SNOMEDCT:45709008", "d": []}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "CL:0002607", "l": "migratory enteric neural crest cell", "d": ["A neural crest cell that gives rise to cells of the enteric nervous system."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:4030051", "l": "nucleus accumbens shell and olfactory tubercle D1 medium spiny neuron", "d": ["A DRD1-expressing medium spiny neuron that is part of a nucleus accumbens shell or olfactory tubercle."]}]}
{"type": "biolink:Cell", "ic": "77.488267285704651", "identifiers": [{"i": "CL:0019031", "l": "intestine goblet cell", "d": ["Goblet cells reside throughout the length of the small and large intestine and are responsible for the production and maintenance of the protective mucus blanket by synthesizing and secreting high-molecular-weight glycoproteins known as mucins. Human intestinal goblet cells secrete the MUC2 mucin, as well as a number of typical mucus components: CLCA1, FCGBP, AGR2, ZG16, and TFF3."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0333742", "l": "Syncytial cell", "d": []}, {"i": "SNOMEDCT:72263005", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1520009", "l": "Virchow Cell", "d": []}, {"i": "NCIT:C33876", "l": "Virchow Cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1276852", "l": "Entire parathyroid transitional cell", "d": []}, {"i": "SNOMEDCT:177728006", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4696000", "l": "Cells.CD3+CD4+CD27-CD45RO+CD62L-", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C4725929", "l": "Autologous EGFR-specific CAR-T-Cells Expressing Anti-PD-1/CTLA-4 Antibodies", "d": []}, {"i": "NCIT:C150695", "l": "Autologous EGFR-specific CAR-T-Cells Expressing Anti-PD-1/CTLA-4 Antibodies", "d": ["A preparation of autologous T-lymphocytes that have been activated and genetically modified to express immune checkpoint antibodies against the negative immunoregulatory receptors human cell surface receptor programmed cell death protein 1 (PD-1; PDCD1; CD279) and human T-cell receptor cytotoxic T-lymphocyte-associated antigen 4 (CTLA4; CTLA-4), and are transduced with a gene encoding a chimeric antigen receptor (CAR) specific for the human tumor-associated antigen (TAA) epidermal growth factor receptor (EGFR), with potential immunomodulating and antineoplastic activities. After isolation, activation, transduction, expansion in culture and reintroduction into the patient, the T-cells in the autologous EGFR specific CAR-T-cells expressing anti-PD-1/CTLA4 antibodies  specifically target and kill EGFR-expressing tumor cells. The anti-PD-1 antibody secreted from the CAR-T cells binds to PD-1 expressed on T-cells and prevents the interaction of PD-1 with its ligand programmed cell death 1 ligand 1 (PD-L1, PD-1L1; CD274) expressed on cancer cells, which prevents PD-1-mediated signaling and T-cell exhaustion. The anti-CTLA4 expressed by the CAR-T cells targets and binds to CTLA4 expressed on T-cells, and inhibits the CTLA4-mediated downregulation of T-cell activation. Both antibodies enhance T-cell activation, improve immunosuppression in the tumor microenvironment (TME) and improve the T-cell mediated immune response against and toxicity in EGFR-expressing tumor cells. Both PD-1 and CTLA-4 negatively regulate T-cell activation and proliferation, and play a key role in immunosuppression within the TME. EGFR, a receptor tyrosine kinase that is overexpressed in a variety of cancer cell types, plays a key role in tumor cell proliferation."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:1001595", "l": "rectum glandular cell", "d": ["Glandular cell of rectal epithelium. Example: Goblet cell; enterocytes or absorptive cells; enteroendocrine and M cells."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5163731", "l": "Erythrocytes | Vitreous fluid | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5690104", "l": "Cells.CD4.Tumor necrosis factor alfa-expressing", "d": []}]}
{"type": "biolink:Cell", "ic": "92.728541327098611", "identifiers": [{"i": "CL:0011113", "l": "spiral ganglion neuron", "d": ["Neuron found in the spiral ganglion."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1520103", "l": "WA01 cell line", "d": []}, {"i": "NCIT:C20308", "l": "WA01", "d": ["Provider: Wisconsin Alumni Research Foundation (WARF), Madison, WI. Information from provider and not independently verified by NIH: Cells are positive for cell markers SSEA-3, SSEA-4, TRA-1-60, TRA-1-81, and alkaline phosphatase; Cells are negative for SSEA-1; Give rise to teratomas containing derivatives of three germ layers in SCID mice; Differentiate in vitro; Documented quality control includes karyotype analysis, DNA fingerprinting, mycoplasma testing, and human virus testing. Frozen vials of cells in passage 22 are available immediately. Publication: Thomson et al., Science 282, 1145, 1998. This cell line meets the criteria for the use of human embryonic stem cells by federally funded researchers."]}]}
{"type": "biolink:Cell", "ic": "85.457082654197222", "identifiers": [{"i": "UMLS:C1514032", "l": "Neoplastic Protoplasmic Astrocyte", "d": []}, {"i": "NCIT:C41459", "l": "Neoplastic Protoplasmic Astrocyte", "d": []}]}
{"type": "biolink:Cell", "ic": "84.75972595860604", "identifiers": [{"i": "UMLS:C0682545", "l": "Basophil cell", "d": []}, {"i": "NCIT:C32198", "l": "Basophilic Cell", "d": ["A cell whose cytoplasm or granules stain readily with basic dyes."]}]}
{"type": "biolink:Cell", "ic": "92.728541327098611", "identifiers": [{"i": "CL:0002119", "l": "CD38-positive IgG-negative class switched memory B cell", "d": ["A CD38-positive IgG-negative memory B cell is an IgG-negative class switched memory B cell that lacks IgG on the cell surface with the phenotype CD38-positive and IgG-negative."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5175161", "l": "Nucleated erythrocytes | Synovial fluid | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "ic": "81.247621244257502", "identifiers": [{"i": "CL:0000107", "l": "autonomic neuron", "d": ["A neuron whose cell body is within an autonomic ganglion."]}]}
{"type": "biolink:Cell", "ic": "73.847638787057321", "identifiers": [{"i": "CL:0010003", "l": "epithelial cell of alveolus of lung", "d": ["An epithelial cell that is part_of a alveolus of lung."]}]}
{"type": "biolink:Cell", "ic": "74.659114980698789", "identifiers": [{"i": "UMLS:C1514053", "l": "Neoplastic Oligodendrocyte", "d": []}, {"i": "NCIT:C37141", "l": "Neoplastic Oligodendrocyte", "d": []}]}
{"type": "biolink:Cell", "ic": "92.728541327098611", "identifiers": [{"i": "CL:0001010", "l": "mature dermal dendritic cell", "d": ["Mature dermal dendritic cell is a dermal dendritic cell that is CD80-high, CD86-high, MHCII-high and is CD83-positive."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C4733638", "l": "Allogeneic HPV-specific Cytotoxic T Lymphocytes", "d": []}, {"i": "NCIT:C155881", "l": "Allogeneic HPV-specific Cytotoxic T Lymphocytes", "d": ["A population of allogeneic cytotoxic T-lymphocytes (CTLs) that are specifically reactive to human papillomavirus (HPV), with potential antiviral and antineoplastic activities. Upon infusion of the allogeneic HPV-specific CTLs, these CTLs induce selective toxicity in HPV-positive cancer cells and other HPV-infected cells. HPV is associated with various cancer cell types."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4304486", "l": "Population of all nonhematic cells in portion of fluid", "d": []}, {"i": "SNOMEDCT:719702007", "d": []}]}
{"type": "biolink:Cell", "ic": "76.46797986554256", "identifiers": [{"i": "UMLS:C1510732", "l": "Abnormal Myoepithelial Cell", "d": []}, {"i": "NCIT:C36769", "l": "Abnormal Myoepithelial Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C2698236", "l": "Mobilized Peripheral Blood Stem Cell", "d": []}, {"i": "NCIT:C75576", "l": "Mobilized Peripheral Blood Stem Cell", "d": ["Blood stem cells found in the circulation after being stimulated to leave the bone marrow, usually by treatment with a cytokine or other drug."]}]}
{"type": "biolink:Cell", "ic": "88.140761698499901", "identifiers": [{"i": "CL:1000353", "l": "microfold cell of epithelium of small intestine", "d": ["A M cell that is part of the epithelium of small intestine."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1370100", "l": "Cells.CD3+TCR alpha beta+", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0009013", "l": "fetal hepatobiliary progenitor cell", "d": ["A progenitor cell with hepatic and biliary lineage potential, identified in mouse and human, and anatomically restricted to the ductal plate of fetal liver."]}]}
{"type": "biolink:Cell", "ic": "88.140761698499901", "identifiers": [{"i": "CL:0002131", "l": "regular ventricular cardiac myocyte", "d": ["Regular cardiac myocyte of a cardiac ventricle."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0596208", "l": "brain cell", "d": []}]}
{"type": "biolink:Cell", "ic": "92.728541327098611", "identifiers": [{"i": "CL:0002303", "l": "pigmented ciliary epithelial cell", "d": ["A cell that is part of pigmented ciliary epithelium. This cell type uptakes sodium and chloride ions from stromal interstitium and passes the ions to non-pigmented ciliary epithelial cells via gap junctions."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0080261", "l": "Tumor-Derived Activated Cells", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:1000720", "l": "kidney papillary duct intercalated cell", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C3642419", "l": "Autologous Pluripotent ALDHbr Stem Cells ALD-451", "d": []}, {"i": "NCIT:C78466", "l": "Autologous Pluripotent ALDHbr Stem Cells ALD-451", "d": ["A specific population of autologous, pluripotent bone marrow derived cells that express high levels of the cytosolic enzyme aldehyde dehydrogenase (ALDH) with potential protective and neuro-cognition improving activity. Expression of high levels of ALDH is an indicator of the biological activity in heterogenous early stage stem cells. Upon intravenous administration, these ALDH bright cells may protect normal cells and may repair damaged cells. These cells may also protect brain cells from damage and may improve neurocognition."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5163711", "l": "Erythrocytes | Bone marrow | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "ic": "73.357135392541679", "identifiers": [{"i": "CL:0000814", "l": "mature NK T cell", "d": ["A mature alpha-beta T cell of a distinct lineage that bears natural killer markers and a T cell receptor specific for a limited set of ligands. NK T cells have activation and regulatory roles particularly early in an immune response."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5706862", "l": "Equecabtagene Autoleucel", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1181300", "l": "Active chief cell of parathyroid gland", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5708028", "l": "Voxeralgagene Autotemcel", "d": []}]}
{"type": "biolink:Cell", "ic": "90.82444074280258", "identifiers": [{"i": "CL:1000339", "l": "enterocyte of epithelium proper of small intestine", "d": ["An enterocyte that is part of the epithelium proper of small intestine."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1979635", "l": "Blasts.CD11b", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1267951", "l": "Lymphocyte positive for CD59 antigen", "d": []}, {"i": "SNOMEDCT:117392001", "d": []}]}
{"type": "biolink:Cell", "ic": "90.82444074280258", "identifiers": [{"i": "UMLS:C1512637", "l": "Immature Peripheral Alpha/Beta Cell of Cytotoxic Type", "d": []}, {"i": "NCIT:C38327", "l": "Immature Peripheral Alpha/Beta Cell of Cytotoxic Type", "d": ["A cell derived from stem cells in the bone marrow. It is a maturing T lymphocyte that expresses an alpha-beta antigen specific surface receptor (TCR) and the CD8 surface marker. These cells mature in the thymus."]}]}
{"type": "biolink:Cell", "ic": "71.079643100360357", "identifiers": [{"i": "UMLS:C1519354", "l": "Skin squamous cell", "d": []}, {"i": "NCIT:C33562", "l": "Skin Squamous Cell", "d": ["A flat, scale-like epithelial cell found on the outer covering of the body."]}]}
{"type": "biolink:Cell", "ic": "48.195956441484803", "identifiers": [{"i": "CL:0000056", "l": "myoblast", "d": ["A cell that is commited to differentiating into a muscle cell.  Embryonic myoblasts develop from the mesoderm. They undergo proliferation, migrate to their various sites, and then differentiate into the appropriate form of myocytes.  Myoblasts also occur as transient populations of cells in muscles undergoing repair."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5707658", "l": "Autologous Anti-H3.3K27M TCR-expressing T-cells", "d": []}, {"i": "NCIT:C188203", "l": "Autologous Anti-H3.3K27M TCR-expressing T-cells", "d": ["A preparation of autologous T-lymphocytes that have been genetically engineered to express a T-cell receptor (TCR) specific for the histone H3.3 containing the amino acid substitution mutation lysine (Lys) 27-to-methionine (H3.3K27M), with potential immunomodulating and antineoplastic activities. Upon administration, the autologous anti-H3.3K27M TCR-expressing T-cells specifically target and bind to H3.3K27M-expressing tumor cells. This leads to T-cell activation and T-cell mediated lysis of H3.3K27M-expressing tumor cells. The H3.3K27M mutation alters the methylation and acetylation profile of the histone H3 variant H3.3 at Lys 27. Modification of H3.3 at Lys 27 regulates gene expression, and the H3.3K27M mutation occurs in a variety of cancer cell types."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0682696", "l": "Golgi type I neuron", "d": []}]}
{"type": "biolink:Cell", "ic": "82.076046914303362", "identifiers": [{"i": "UMLS:C1514201", "l": "Polygonal Adenocarcinoma Cell with Eosinophilic Cytoplasm", "d": []}, {"i": "NCIT:C36850", "l": "Polygonal Adenocarcinoma Cell with Eosinophilic Cytoplasm", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0004213", "l": "type 3a cone bipolar cell", "d": ["A type of type 3 cone bipolar cell with distinctive curly dendrites."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1277067", "l": "Entire corneal corpuscle", "d": []}, {"i": "SNOMEDCT:368826000", "d": []}]}
{"type": "biolink:Cell", "ic": "92.728541327098611", "identifiers": [{"i": "CL:4028001", "l": "pulmonary capillary endothelial cell", "d": ["Any capillary endothelial cell that is part of a lung."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C4724925", "l": "Autologous CD34-positive BCL11A-disrupted Hematopoietic Progenitor Cells ST-400", "d": []}, {"i": "NCIT:C148240", "l": "Autologous CD34-positive BCL11A-disrupted Hematopoietic Progenitor Cells ST-400", "d": ["A population of autologous CD34-positive, B-cell lymphoma/leukemia 11A (BCL11A)-disrupted hematopoietic progenitor cells (HPCs) that may be used for bone marrow autotransplantation. CD34-positive HPCs are isolated from human blood upon apheresis and are genetically modified in vitro using a proprietary zinc finger nuclease (ZFN) technology to specifically disrupt the transcriptional enhancer sequence for the BCL11A gene. Upon infusion into the patient following conditioning chemotherapy, the autologous CD34-positive BCL11A-disrupted HPCs ST-400 can populate the bone marrow and differentiate into a variety of blood cell types including lymphoid cells, myeloid cells and erythroblasts. BCL11A is a suppressor of fetal hemoglobin (HbF) expression. Therefore, disruption of the BCL11A enhancer decreases the expression of BCL11A and stimulates the expression of HbF in erythrocytes that differentiate from ST-400. HbF may compensate for reduced or absent expression of adult hemoglobin in patients, including those with transfusion-dependent beta-thalassemia."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0546501", "l": "P.B. promegakaryocyte", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C3827754", "l": "Tumor Infiltrating Macrophages", "d": []}, {"i": "NCIT:C111027", "l": "Tumor Infiltrating Macrophages", "d": ["Non-neoplastic macrophages that infiltrate a tumor."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1522158", "l": "Leukocyte - Myeloblast (MMHCC)", "d": []}, {"i": "NCIT:C22589", "l": "Mouse Myeloblast", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1513301", "l": "Mikulicz Cell", "d": []}, {"i": "NCIT:C36738", "l": "Mikulicz Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "92.728541327098611", "identifiers": [{"i": "CL:0002233", "l": "epithelial cell of prostatic acinus", "d": ["An epithelial cell of the prostatic acinus."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5184417", "l": "Unspecified cells | Body fluid | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1440262", "l": "Cells.CD16-CD57+", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1512309", "l": "HL-60/MX2", "d": []}, {"i": "NCIT:C20229", "l": "HL-60/MX2", "d": ["HL-60/MX2 is a mitoxantrone resistant derivative of the HL-60 cell line. HL-60/MX2 is approximately 35 fold less sensitive to mitoxantrone than the HL-60 parental cells. HL-60/MX2 cells are cross-resistant to etoposide, teniposide, bisantrene, dactinomycin, 4'-(9-acridinylamino)methane- sulfon-m-anisidide, and the anthracyclines daunorubicin and doxorubicin but retain sensitivity to the Vinca alkaloids vincristine and vinblastine, melphalan, mitomycin C and cisplatin. In addition, the HL-60/MX2 cells display slight collateral sensitivity to bleomycin. Resistance to mitoxantrone is stable for up to six months."]}]}
{"type": "biolink:Cell", "ic": "83.023198044254755", "identifiers": [{"i": "CL:0005012", "l": "multi-ciliated epithelial cell", "d": ["A ciliated epithelial cell with many cilia."]}]}
{"type": "biolink:Cell", "ic": "86.236661114203869", "identifiers": [{"i": "CL:1000351", "l": "basal cell of epithelium of respiratory bronchiole", "d": ["A basal cell that is part of the epithelium of respiratory bronchiole."]}]}
{"type": "biolink:Cell", "ic": "84.128890093485552", "identifiers": [{"i": "CL:0000638", "l": "acidophil cell of pars distalis of adenohypophysis", "d": ["An acidophilic chromophil cell that of the anterior pituitary gland."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0229652", "l": "Basophilic megakaryocyte", "d": []}, {"i": "SNOMEDCT:75790005", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5382938", "l": "Interferon-gamma producing Cytomegalovirus-specific CD8 cells | Blood | Cell markers", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4246480", "l": "Non-ectomesenchymal cell", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002121", "l": "CD24-negative CD38-negative IgG-negative class switched memory B cell", "d": ["A CD24-negative CD38-negative IgG-negative memory B cell is a CD38-negative IgG-negative class switched memory B cell that lacks IgG on the cell surface with the phenotype CD24-negative, CD38-negative, and IgG-negative."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4699464", "l": "Monotypic kappa plasma cells", "d": []}]}
{"type": "biolink:Cell", "ic": "78.96520244130248", "identifiers": [{"i": "UMLS:C1514052", "l": "Neoplastic Oligodendrocyte-Like Cell", "d": []}, {"i": "NCIT:C37147", "l": "Neoplastic Oligodendrocyte-Like Cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157555", "l": "CD4+CD45RO+ cells | XXX | Cell markers", "d": []}]}
{"type": "biolink:Cell", "ic": "90.82444074280258", "identifiers": [{"i": "CL:1001064", "l": "kidney artery smooth muscle cell", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5417908", "l": "Anti-CD19 Antibody-T-cell Receptor-expressing T-cells ET019003", "d": []}, {"i": "NCIT:C172202", "l": "Anti-CD19 Antibody-T-cell Receptor-expressing T-cells ET019003", "d": ["A preparation of T-lymphocytes that have been engineered by incorporating an as of yet undisclosed co-stimulatory molecule into T-cells expressing an anti-CD19 antibody T-cell receptor (AbTCR) structure (ET190L1), with potential immunostimulating and antineoplastic activities. Upon administration, anti-CD19 AbTCR-expressing T-cells ET019003 targets and binds to CD19-expressing tumor cells. This results in cytotoxic T-lymphocyte (CTL)-mediated elimination of CD19-positive tumor cells. The binding to CD19-expressing tumor cells may also activate the undisclosed costimulatory domain, leading to further T-cell proliferation. CD19 antigen is a B-cell specific cell surface antigen overexpressed in B-cell lineage malignancies. ET019003 is able to match the anticancer activity of chimeric antigen receptor (CAR) T-cells, while they are less likely to stimulate cytokine release syndrome (CRS) and less likely to cause cytokine-related toxicities."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5420910", "l": "Mipetresgene Autoleucel", "d": []}, {"i": "NCIT:C174683", "l": "Mipetresgene Autoleucel", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5182912", "l": "Terminal deoxyribonucleotidyl transferase cells | Body fluid | Cell markers", "d": []}]}
{"type": "biolink:Cell", "ic": "77.488267285704651", "identifiers": [{"i": "CL:0002073", "l": "transitional myocyte", "d": ["Specialized cardiac myocyte which is in the internodal tract and atrioventricular node. The cell is more slender than ordinary atrial myocytes and has more myofibrils than nodal myocytes."]}]}
{"type": "biolink:Cell", "ic": "73.721563224321088", "identifiers": [{"i": "CL:0000786", "l": "plasma cell", "d": ["A terminally differentiated, post-mitotic, antibody secreting cell of the B cell lineage with the phenotype CD138-positive, surface immunonoglobulin-negative, and MHC Class II-negative. Plasma cells are oval or round with extensive rough endoplasmic reticulum, a well-developed Golgi apparatus, and a round nucleus having a characteristic cartwheel heterochromatin pattern and are devoted to producing large amounts of immunoglobulin."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0009044", "l": "lymphocyte of small intestine lamina propria", "d": ["A lymphocyte that resides in the lamina propria of the small intestine. Lamina propria leukocytes and intraepithelial lymphocytes are the effector compartments of the gut mucosal immune system. Lymphocytes circulate through gut associated lymphoid tissues until recruitment by intestinal antigens. They are involved in the gut immune response."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2322797", "l": "Parasympathetic ganglion neuron", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:1000721", "l": "kidney papillary duct principal cell", "d": []}]}
{"type": "biolink:Cell", "ic": "49.012600093101028", "identifiers": [{"i": "CL:0000101", "l": "sensory neuron", "d": ["Any neuron having a sensory function; an afferent neuron conveying sensory impulses."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5690232", "l": "Leukocytes | Amniotic fluid | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:4023127", "l": "arcuate nucleus of hypothalamus KNDy neuron", "d": ["a KNDy neuron that is located in the arcuate nucleus of the hypothalamus."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0000759", "l": "type 7 cone bipolar cell (sensu Mus)", "d": ["An ON-bipolar neuron found in the retina and having connections with cone photoreceptors cells and neurons in the inner half of the inner plexiform layer. The axon terminal is narrowly stratified and are found just below a calretinin-expressing band in sublamina 4 of the inner plexiform layer."]}]}
{"type": "biolink:Cell", "ic": "86.236661114203869", "identifiers": [{"i": "CL:4023028", "l": "L5 non-Martinotti sst GABAergic interneuron (Mmus)", "d": ["A sst GABAergic cortical interneuron with a soma found in lower L5 with mostly local axonal arborization but with some sparse ascending axons. L5 non-Martinotti sst cells show somatic localization and local axon plexus in L5b and L5b/6 and substantial innervation of L3 and L4, and receive thalamic input from the ventral posteromedial nucleus and specifically target L4 neurons, avoiding L5 pyramidal cells. L5 non-Martinotti sst cells tend to show a higher input resistance and seem to be less stuttering."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5216220", "l": "Granulocytes.immature|NCnc|Pt|Bld", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:1001123", "l": "kidney outer medulla peritubular capillary cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5170948", "l": "Leukocytes | XXX | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0009032", "l": "B cell of appendix", "d": ["A B cell that is located in a vermiform appendix."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:2000023", "l": "spinal cord ventral column interneuron", "d": ["Any interneuron that is part of a spinal cord ventral column."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1955940", "l": "Common Lymphoid Progenitors", "d": []}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "CL:0000770", "l": "band form basophil", "d": ["A late basophilic metamyelocyte in which the nucleus is in the form of a curved or coiled band, not having acquired the typical multilobar shape of the mature basophil."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1440317", "l": "Cells.CD45RO", "d": []}]}
{"type": "biolink:Cell", "ic": "83.023198044254755", "identifiers": [{"i": "UMLS:C1518240", "l": "Malignant Polygonal Cell with Abundant Granular Cytoplasm", "d": []}, {"i": "NCIT:C36884", "l": "Malignant Polygonal Cell with Abundant Granular Cytoplasm", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157345", "l": "CD19 cells | Blood | Cell markers", "d": []}]}
{"type": "biolink:Cell", "ic": "75.26123597683771", "identifiers": [{"i": "UMLS:C1708880", "l": "Malignant Goblet-Like Mucous Cell", "d": []}, {"i": "NCIT:C47812", "l": "Malignant Goblet-Like Mucous Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0009024", "l": "mesothelial cell of small intestine", "d": ["A mesothelial cell that is part of the small intestine."]}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "CL:0002401", "l": "mature dendritic epithelial T cell precursor", "d": ["A thymocyte that has a T cell receptor consisting of a gamma chain that has as part a Vgamma3 segment, and a delta chain. This cell type is CD4-negative, CD8-negative and CD24-negative. This cell-type is found in the fetal thymus with highest numbers occurring at E17-E18."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C3899973", "l": "idecabtagene vicleucel", "d": []}, {"i": "MESH:C000715380", "l": "idecabtagene vicleucel", "d": []}, {"i": "SNOMEDCT:1156047000", "d": []}, {"i": "SNOMEDCT:1156050002", "d": []}]}
{"type": "biolink:Cell", "ic": "90.82444074280258", "identifiers": [{"i": "UMLS:C1513980", "l": "Neoplastic Gonadotroph Cell", "d": []}, {"i": "NCIT:C36921", "l": "Neoplastic Gonadotroph Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "UMLS:C1879789", "l": "Basophilic Adenocarcinoma Cell", "d": []}, {"i": "NCIT:C61051", "l": "Basophilic Adenocarcinoma Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "75.923665061460838", "identifiers": [{"i": "UMLS:C1511241", "l": "Bone Marrow-Homing Plasma Cell", "d": []}, {"i": "NCIT:C41032", "l": "Bone Marrow-Homing Plasma Cell", "d": ["A mature white blood cell, differentiated in the bone marrow, activated to preferentially migrate to the bone marrow."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2953241", "l": "Interdigitating dendritic cell of lymph node", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0333845", "l": "Polyploid plasmablast", "d": []}, {"i": "SNOMEDCT:55093000", "d": []}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "UMLS:C0229650", "l": "Megakaryoblasts", "d": []}, {"i": "NCIT:C13122", "l": "Megakaryoblast", "d": ["The precursor of a megakaryocyte."]}, {"i": "SNOMEDCT:27852005", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5761798", "l": "CD4CAR T cells", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1267848", "l": "Lymphocyte positive for both CD5 antigen and CD25 antigen", "d": []}, {"i": "SNOMEDCT:116818000", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157403", "l": "CD23+CD38+ cells | Blood | Cell markers", "d": []}]}
{"type": "biolink:Cell", "ic": "80.511444690059548", "identifiers": [{"i": "UMLS:C1519467", "l": "Spindle Melanocyte", "d": []}, {"i": "NCIT:C36869", "l": "Spindle Melanocyte", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002057", "l": "CD14-positive, CD16-negative classical monocyte", "d": ["A classical monocyte that is CD14-positive, CD16-negative, CD64-positive, CD163-positive."]}]}
{"type": "biolink:Cell", "ic": "70.99638707280991", "identifiers": [{"i": "UMLS:C1514030", "l": "Neoplastic Multinucleated Giant Cell", "d": []}, {"i": "NCIT:C36819", "l": "Neoplastic Multinucleated Giant Cell", "d": ["A benign or malignant neoplastic large cell that contains multiple nuclei and an abundant amount of cytoplasm."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0001077", "l": "ILC1, human", "d": ["An ILC1 cell in the human with the phenotype CD56-negative, IL-7Ralpha-positive, T-bet-positive."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002399", "l": "CD1c-positive myeloid dendritic cell", "d": ["A myeloid dendritic cell found in the blood that is CD1c-positive."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1267881", "l": "Lymphocyte negative for CD16 antigen and positive for CD34 antigen", "d": []}, {"i": "SNOMEDCT:117558000", "d": []}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "CL:0001068", "l": "ILC1", "d": ["A group 1 innate lymphoid cell that is non-cytotoxic."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157476", "l": "CD30 cells | Blood | Cell markers", "d": []}]}
{"type": "biolink:Cell", "ic": "80.511444690059548", "identifiers": [{"i": "UMLS:C0682546", "l": "Acidophil cell", "d": []}, {"i": "NCIT:C32044", "l": "Acidophilic Cell", "d": ["A cell whose cytoplasm or its granules stain with acid dyes."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1440271", "l": "Cells.CD2+CD20+", "d": []}]}
{"type": "biolink:Cell", "ic": "92.728541327098611", "identifiers": [{"i": "CL:4023112", "l": "vestibular afferent neuron", "d": ["An afferent neuron of the vestibular system that innervate the base of the hair cell and increase or decrease their neural firing rate as the receptor cell is excited or inhibited."]}]}
{"type": "biolink:Cell", "ic": "76.281523396999802", "identifiers": [{"i": "CL:0000556", "l": "megakaryocyte", "d": ["A large hematopoietic cell (50 to 100 micron) with a lobated nucleus. Once mature, this cell undergoes multiple rounds of endomitosis and cytoplasmic restructuring to allow platelet formation and release."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2337177", "l": "Mesothelial cell of parietal pleura", "d": []}]}
{"type": "biolink:Cell", "ic": "79.849015605436421", "identifiers": [{"i": "CL:0000594", "l": "skeletal muscle satellite cell", "d": ["An elongated, spindle-shaped, cell that is located between the basal lamina and the plasmalemma of a muscle fiber. These cells are mostly quiescent, but upon activation they divide to produce cells that generate new muscle fibers."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:4033011", "l": "smooth muscle cell of large intestine smooth muscle circular layer", "d": ["A(n) smooth muscle cell that is part of a(n) large intestine smooth muscle circular layer."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5171869", "l": "Macrophages | Pleural fluid | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5220580", "l": "Erythrocytes.dysmorphic|Urine/Urine sed", "d": []}]}
{"type": "biolink:Cell", "ic": "75.26123597683771", "identifiers": [{"i": "UMLS:C1881542", "l": "Malignant Cutaneous Basal Cell", "d": []}, {"i": "NCIT:C60783", "l": "Malignant Cutaneous Basal Cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157301", "l": "CD135 blasts | Bone marrow | Cell markers", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0009020", "l": "tuft cell of appendix", "d": ["An intestinal tuft cell that is a part of a vermiform appendix."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C0879438", "l": "Allogeneic Lymphocyte", "d": []}, {"i": "NCIT:C13396", "l": "Allogeneic Lymphocyte", "d": ["A cell that is antigenically distinct from other lymphocytes."]}, {"i": "NCIT:C28676", "l": "Therapeutic Allogeneic Lymphocytes", "d": ["A population of lymphocytes therapeutically administered to a recipient individual who is genetically distinct from a donor of the same species. (NCI04)"]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4249177", "l": "Primitive endodermal cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1183176", "l": "Set of aminergic cells in reticular formation", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1268006", "l": "Neutrophilic granulocytic cell", "d": []}, {"i": "SNOMEDCT:127913001", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C4745172", "l": "Human Anti-CD30 CAR-expressing Autologous T-lymphocytes", "d": []}, {"i": "NCIT:C156933", "l": "Human Anti-CD30 CAR-expressing Autologous T-lymphocytes", "d": ["A preparation of autologous T-lymphocytes that have been genetically modified to express a chimeric antigen receptor (CAR) consisting of a single chain variable fragment (scFv) derived from a human anti-CD30 monoclonal antibody, with potential immunostimulating and antineoplastic activities. Upon administration, the human anti-CD30 CAR-expressing autologous T-lymphocytes specifically recognize and bind to CD30-expressing tumor cells, resulting in tumor cell lysis. CD30, a cell surface receptor and a member of the tumor necrosis factor (TNF) receptor superfamily, is transiently expressed on activated lymphocytes and is constitutively expressed in hematologic malignancies. Compared to CAR-T cells that use murine scFv-based CARs, CAR-T cells containing CARs with human scFv regions reduces the immunogenicity of the CAR-T cells and may improve their longevity."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157596", "l": "CD5+CD19+ cells | Blood | Cell markers", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0314591", "l": "Colony-forming unit of lymphoid-myeloid lineage", "d": []}, {"i": "SNOMEDCT:444995008", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:2000059", "l": "prostate gland microvascular endothelial cell", "d": ["Any microvascular endothelial cell that is part of a prostate gland."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4267790", "l": "Cells.CD27+CD45RA+", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1440404", "l": "Cells.t(12;21)(p13;q22.3)(ETV6,RUNX1)", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5688427", "l": "Population of all cells positive for estrogen receptor in portion of fluid", "d": []}, {"i": "SNOMEDCT:1222875003", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157650", "l": "CD7 cells | Blood | Cell markers", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5163689", "l": "Erythrocyte inclusion bodies | Blood | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:1000349", "l": "basal cell of epithelium of bronchus", "d": ["A basal cell found in the bronchus epithelium."]}]}
{"type": "biolink:Cell", "ic": "73.476395680690302", "identifiers": [{"i": "UMLS:C1514054", "l": "Neoplastic Oncocyte", "d": []}, {"i": "NCIT:C36941", "l": "Neoplastic Oncocyte", "d": []}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "CL:0000372", "l": "tormogen cell", "d": ["An epidermal cell that is part of a cell cluster organ of the insect integument (such as a sensillum) and that secretes a cuticular specialization that forms a socket around the base of a cuticular specialization produced by a trichogen cell."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5382907", "l": "HLA-B7 CMV specific CD8 cells | Blood | Cell markers", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2336695", "l": "Hepatic oval stem cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0524459", "l": "Lower motor neuron", "d": []}, {"i": "SNOMEDCT:91770004", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4512352", "l": "Entire primary sclerotic mastoid cell", "d": []}, {"i": "SNOMEDCT:727108007", "d": []}]}
{"type": "biolink:Cell", "ic": "92.728541327098611", "identifiers": [{"i": "CL:0000853", "l": "olfactory epithelial supporting cell", "d": ["Olfactory epithelial support cell is a columnar cell that extends from the epithelial free margin to the basement membrane of the olfactory epithelium. This cell type has a large, vertically, elongate, euchromatic nucleus, along with other nuclei, forms a layer superficial to the cell body of the receptor cell; sends long somewhat irregular microvilli into the mucus layer; at the base, with expanded end-feet containing numerous lamellated dense bodies resembling lipofuscin of neurons."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5171976", "l": "Malignant cells/100 cells | Urine | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1440049", "l": "Abnormal blood cells.CD13", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1514842", "l": "Renal interstitial cell", "d": []}, {"i": "NCIT:C33458", "l": "Renal Interstitial Cell", "d": ["A cell of the interstitial tissue of the renal parenchyma. A renal interstitial cell is one of two types. A type I interstitial cell is a fibroblastic cell that is active in the deposition and degradation of the interstitial matrix. It contributes to fibrosis in response to chronic irritation. A type II cell is a macrophage-derived mononuclear cell with phagocytic and immunologic properties. A type II cell is important in antigen presentation. Its cytokines contribute to recruitment of infiltrating cells, progression of injury, and sustenance of fibrogenesis."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0009080", "l": "tuft cell of small intestine", "d": ["A tuft cell located in the small intestine."]}]}
{"type": "biolink:Cell", "ic": "87.120474278337809", "identifiers": [{"i": "CL:0000974", "l": "long lived plasma cell", "d": ["A fully differentiated plasma cell that lives for years, as opposed to months, secretes immunoglobulin, and has the phenotype weakly CD19-positive, CD20-negative, CD38-negative, strongly CD138-positive, MHC Class II-negative, surface immunoglobulin-negative, IgD-negative, and strongly CXCR4-positive. The majority of these cells of this type reside in the bone marrow."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157670", "l": "CD8+CD45RA+ cells | Blood | Cell markers", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1514438", "l": "Primitive Mesenchymal Stellate Cell", "d": []}, {"i": "NCIT:C36928", "l": "Primitive Mesenchymal Stellate Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1516922", "l": "Mouse Epididymal Interstitial Cell", "d": []}, {"i": "NCIT:C22171", "l": "Mouse Epididymal Interstitial Cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5163552", "l": "Epithelial cells.renal | Urine | Urinalysis", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0546499", "l": "P.B. plasma cell", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:1000385", "l": "type 2 vestibular sensory cell of epithelium of crista of ampulla of semicircular duct of membranous labyrinth", "d": ["A type II vestibular sensory cell that is part of the epithelium of crista of ampulla of semicircular duct of membranous labyrinth."]}]}
{"type": "biolink:Cell", "ic": "55.277439429001859", "identifiers": [{"i": "CL:0000228", "l": "multinucleate cell", "d": ["A cell with more than one nucleus."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5171959", "l": "Malignant cells | Blood | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4518154", "l": "Population of all spermatozoa with abnormal tail in portion of fluid", "d": []}, {"i": "SNOMEDCT:725227009", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2335684", "l": "Myocyte of anterior internodal tract", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0003017", "l": "retinal ganglion cell B3 outer", "d": ["A retinal ganglion B cell that has post synaptic terminals in S2."]}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "CL:1000425", "l": "chromaffin cell of paraganglion", "d": ["A chromaffin cell that is part of the paraganglion."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2333350", "l": "Muscle Fibers, Intermediate", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:4033010", "l": "neuroendocrine cell of epithelium of lobar bronchus", "d": ["A(n) neuroendocrine cell that is part of a(n) epithelium of lobar bronchus."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5177458", "l": "Plasma cells immature | Bone marrow | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "ic": "82.532694649739099", "identifiers": [{"i": "UMLS:C1513977", "l": "Neoplastic Glandular Cell with Eosinophilic Granular Cytoplasm", "d": []}, {"i": "NCIT:C36881", "l": "Neoplastic Glandular Cell with Eosinophilic Granular Cytoplasm", "d": []}]}
{"type": "biolink:Cell", "ic": "75.923665061460838", "identifiers": [{"i": "UMLS:C1708870", "l": "Malignant Cytotrophoblastic Cell", "d": []}, {"i": "NCIT:C54118", "l": "Malignant Cytotrophoblastic Cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157280", "l": "CD122 cells | Blood | Cell markers", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2339990", "l": "Motor Neurons, Alpha", "d": []}]}
{"type": "biolink:Cell", "ic": "70.99638707280991", "identifiers": [{"i": "UMLS:C1881590", "l": "Malignant Round Germ Cell with Glycogen-Rich Cytoplasm and Round Nucleus", "d": []}, {"i": "NCIT:C61064", "l": "Malignant Round Germ Cell with Glycogen-Rich Cytoplasm and Round Nucleus", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0882937", "l": "Cells.CD8+CD57+", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5173437", "l": "Monocytes | Pleural fluid | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "UMLS:C1519718", "l": "Intercalated cell of collecting duct of renal tubule", "d": []}, {"i": "NCIT:C13146", "l": "Intercalated Cell", "d": ["The intercalated cell is an epithelial cell of the renal collecting tubule that is specialized for H+ and HCO3 transport. These cells exist in two types, [alpha] and [beta]. The [alpha] cell secretes H+ into the lumen by an apical H+ ATPase and a basolateral Cl:HCO3. The [beta] cell secretes HCO3- into the lumen by an apical Cl:HCO3 and a basolateral H+ ATPase."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0546507", "l": "P.B. mast cell", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C4525597", "l": "Autologous Peripheral Blood Mononuclear Cells", "d": []}, {"i": "NCIT:C135058", "l": "Autologous Peripheral Blood Mononuclear Cells", "d": ["A preparation of autologous peripheral blood mononuclear cells (PBMCs)."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4246839", "l": "Sacral/lumbosacral neural crest cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2335776", "l": "Myocardial endocrine cell of septal division of left branch of atrioventricular bundle", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5446899", "l": "Anti-CD20/Anti-CD22 CAR T-cells", "d": []}, {"i": "NCIT:C175977", "l": "Anti-CD20/Anti-CD22 CAR T-cells", "d": ["A preparation of human T-lymphocytes engineered to express chimeric antigen receptors (CARs) specific for the tumor-associated antigens (TAAs) cluster of differentiation 20 (CD20) and CD22, with potential immunostimulating and antineoplastic activities. Upon administration, the anti-CD20/anti-CD22 CAR T-cells target and bind to both CD20 and CD22 expressed on the surface of tumor cells. This induces selective toxicity in tumor cells expressing these TAAs. CD20 and CD22 are overexpressed in certain hematologic malignancies."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1517816", "l": "Leukocyte - Lymphocyte - Immature B-Lymphocyte (MMHCC)", "d": []}, {"i": "NCIT:C22573", "l": "Mouse Immature B-Lymphocyte", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0487022", "l": "Irregularly contracted cell", "d": []}, {"i": "SNOMEDCT:725684008", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0872362", "l": "primitive cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1267874", "l": "Lymphocyte positive for CD15 antigen", "d": []}, {"i": "SNOMEDCT:117553009", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1440300", "l": "Cells.CD36", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1979124", "l": "Blasts.CD126", "d": []}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "CL:0002053", "l": "CD22-positive, CD38-low small pre-B cell", "d": ["A small pre-B cell that is CD22-positive and CD38-low."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5401591", "l": "NKG2D-ACE2 CAR-NK Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "92.728541327098611", "identifiers": [{"i": "CL:0002529", "l": "CD1a-positive dermal dendritic cell", "d": ["A dermal dendritic cell that is CD1a-positive and CD14-negative."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0882871", "l": "Cells.CD41", "d": []}]}
{"type": "biolink:Cell", "ic": "92.728541327098611", "identifiers": [{"i": "UMLS:C1513999", "l": "Neoplastic Large Cell with Abundant Eosinophilic Cytoplasm", "d": []}, {"i": "NCIT:C37106", "l": "Neoplastic Large Cell with Abundant Eosinophilic Cytoplasm", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0009055", "l": "paneth cell of anorectum", "d": ["A paneth cell that is located in the anorectum."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0546445", "l": "Russell-Crooke cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157507", "l": "CD36 cells | Blood | Cell markers", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0003016", "l": "G11-OFF retinal ganglion cell", "d": ["A G11 retinal ganglion cell that has post synaptic terminals in sublaminar layer S2 and is depolarized by decreased illumination of their receptive field center"]}]}
{"type": "biolink:Cell", "ic": "92.728541327098611", "identifiers": [{"i": "CL:0002570", "l": "mesenchymal stem cell of adipose tissue", "d": ["A mesenchymal stem cell of adipose tissue."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157282", "l": "CD123 blasts | Blood | Cell markers", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1183497", "l": "Cell of surface ectoderm", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1440392", "l": "Cells.multiple drug resistance", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1518847", "l": "Pagetoid Cell", "d": []}, {"i": "NCIT:C36871", "l": "Pagetoid Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C3640295", "l": "Allogeneic GM-CSF-secreting Tumor Vaccine PANC 6.03 pcDNA-1/GM-Neo", "d": []}, {"i": "NCIT:C101891", "l": "Allogeneic GM-CSF-secreting Tumor Vaccine PANC 6.03 pcDNA-1/GM-Neo", "d": ["An allogeneic cancer vaccine composed of lethally irradiated, whole pancreatic cancer cells transfected with a plasmid carrying the gene for cytokine granulocyte-macrophage colony-stimulating factor (GM-CSF), with potential immunostimulating and antineoplastic activities. Allogeneic GM-CSF-secreting tumor vaccine PANC 6.03 pcDNA-1/GM-Neo secretes GM-CSF thereby activating dendritic cells, promoting antigen presentation to B- and T-cells, and promoting a cytotoxic T-lymphocyte (CTL) response. This may eventually kill tumor cells. The pancreatic tumor cells are derived from the PANC 6.03 tumor cell line."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C4329367", "l": "Autologous Anti-MG7-CAR T-Lymphocytes", "d": []}, {"i": "NCIT:C131493", "l": "Autologous Anti-MG7-CAR T-Lymphocytes", "d": ["A preparation of autologous, engineered T-lymphocytes that express both a second-generation chimeric antigen receptor (CAR) specific for the human gastric carcinoma-associated antigen MG7, and the co-stimulatory molecule 4-1BB (CD137), with potential antineoplastic activity. Upon intratumoral injection, the autologous anti-MG7-CAR T-lymphocytes target and attach to cancer cells expressing MG7. This induces selective toxicity in and causes lysis of MG7-expressing tumor cells. MG7, a glycosylated protein sequence from the tumor-associated antigen (TAA) carcinoembryonic antigen (CEA), plays a key role in the development of certain tumor cell types. 4-1BB enhances T-cell activation and signaling after recognition of MG7."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5700405", "l": "Autologous Anti-BCMA CAR-T Cells JCARH 125", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1515313", "l": "Mouse Testicular Interstitial Cell", "d": []}, {"i": "NCIT:C22180", "l": "Mouse Testicular Interstitial Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002580", "l": "preadipocyte of the breast", "d": ["A preadipocyte that is part of the breast."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5666940", "l": "Autologous Anti-BCMA CAR T Cells CT103A", "d": []}]}
{"type": "biolink:Cell", "ic": "71.335885432862128", "identifiers": [{"i": "CL:0008003", "l": "somatic muscle myotube", "d": ["A myotube that is part of some somatic muscle.  Examples include arthropod somatic muscle cells."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1953382", "l": "Forward primer", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0333828", "l": "Myeloid cell containing Auer rod(s)", "d": []}, {"i": "SNOMEDCT:74787005", "d": []}]}
{"type": "biolink:Cell", "ic": "73.721563224321088", "identifiers": [{"i": "UMLS:C0022688", "l": "Natural Killer Cells", "d": []}, {"i": "NCIT:C12536", "l": "Natural Killer Cell", "d": ["Natural killer cells are cells that resemble large granular lymphocytes.  They do not express markers of either T or B cell lineage. They are positive for CD16, CD56, and CD 94.  These cells do possess Fc receptors for IgG and can kill target cells using antibody-dependent cell-mediated cytotoxicity. They can also use perforin to kill cells in the absence of antibody and killing may occur without previous sensitization."]}, {"i": "MESH:D007694", "l": "Killer Cells, Natural", "d": []}, {"i": "SNOMEDCT:259717003", "d": []}]}
{"type": "biolink:Cell", "ic": "92.728541327098611", "identifiers": [{"i": "CL:0000460", "l": "glucocorticoid secreting cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5155169", "l": "Blasts | Fetus | Blood | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5421182", "l": "Mocemestrocel", "d": []}, {"i": "NCIT:C175146", "l": "Mocemestrocel", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0011023", "l": "CD25+ mast cell", "d": ["A mast cell that is CD25+."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1440277", "l": "CD28+ cell", "d": []}, {"i": "SNOMEDCT:732270008", "d": []}]}
{"type": "biolink:Cell", "ic": "55.616937789054091", "identifiers": [{"i": "CL:0000236", "l": "B cell", "d": ["A lymphocyte of B lineage that is capable of B cell mediated immunity."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5670966", "l": "Renal Cortical Cell", "d": []}, {"i": "NCIT:C33455", "l": "Renal Cortical Cell", "d": ["A cuboidal glandular epithelial cell found in the renal cortex."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2323184", "l": "Purkinje myocyte of internodal tract", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C3495991", "l": "C2 adrenaline cells", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:4023020", "l": "dynamic gamma motor neuron", "d": ["A gamma motor neuron that innervates dynamic nuclear bag fibers (bag1 fibers) and enhances the sensitivities of Ia sensory neurons. They alter muscle spindle sensitivity and increases its discharge in response to velocity of muscle length (rather than just magnitude)."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0007017", "l": "Stiftchenzellen", "d": ["An epidermal cell with apical microvilli or a single apical projection have synaptic associations with nerve fibres in the epidermis."]}]}
{"type": "biolink:Cell", "ic": "82.532694649739099", "identifiers": [{"i": "CL:1000892", "l": "kidney capillary endothelial cell", "d": []}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "CL:0001001", "l": "immature CD8_alpha-negative CD11b-negative dendritic cell", "d": ["Immature CD8_alpha-negative CD11b-negative dendritic cell is a CD8_alpha-negative CD11b-negative dendritic cell that is CD80-low, CD86-low, and MHCII-low."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0000212", "l": "absorptive cell", "d": ["A cell that takes up and metabolizes substances."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:1000606", "l": "kidney nerve cell", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C0025207", "l": "Melanophores", "d": []}, {"i": "NCIT:C12582", "l": "Melanophore", "d": ["A specialized cell, derived from the neural crest, that contains melanin and regulates changes in pigment."]}, {"i": "MESH:D008547", "l": "Melanophores", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1261568", "l": "Cell positive for CD10 antigen", "d": []}, {"i": "SNOMEDCT:116749001", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:1000286", "l": "smooth muscle cell of rectum", "d": ["A smooth muscle cell that is part of the rectum."]}]}
{"type": "biolink:Cell", "ic": "83.023198044254755", "identifiers": [{"i": "UMLS:C1517204", "l": "Flame Cell", "d": []}, {"i": "NCIT:C37080", "l": "Flame Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "85.457082654197222", "identifiers": [{"i": "UMLS:C1515234", "l": "Technion ES Cell Line", "d": []}, {"i": "NCIT:C20295", "l": "Technion ES Cell Line", "d": []}]}
{"type": "biolink:Cell", "ic": "54.013223975855297", "identifiers": [{"i": "UMLS:C1513951", "l": "Neoplastic Endocrine Cell", "d": []}, {"i": "NCIT:C36925", "l": "Neoplastic Endocrine Cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5168977", "l": "Immature cells | Blood | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2323865", "l": "Non-spiny stellate cell of cerebral cortex", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1116267", "l": "Cells.CD3+IL2R1+", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0596979", "l": "Muller Cells", "d": []}]}
{"type": "biolink:Cell", "ic": "60.545495054889464", "identifiers": [{"i": "CL:0000329", "l": "oxygen accumulating cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1440357", "l": "Cells.CD7-CD13+CD33+", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002359", "l": "placental hematopoietic stem cell", "d": ["A hematopoietic stem cell of the placenta. This cell type is first observed E10.5 This cell type may give rise to fetal liver hematopoietic stem cells."]}]}
{"type": "biolink:Cell", "ic": "76.857431420584163", "identifiers": [{"i": "CL:0000823", "l": "immature natural killer cell", "d": ["A natural killer cell that is developmentally immature and expresses natural killer cell receptors (NKR)."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4518163", "l": "Population of all abnormal spermatozoa in portion of fluid", "d": []}, {"i": "SNOMEDCT:725221005", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2329740", "l": "Set of lymphocytes", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5447470", "l": "Allogeneic Anti-CD19 1XX-CAR T-cells FT819", "d": []}, {"i": "NCIT:C176850", "l": "Allogeneic Anti-CD19 1XX-CAR T-cells FT819", "d": ["A preparation of off-the-shelf (OTS) T-lymphocytes, generated from an induced pluripotent stem cell (iPSC) line, that have been genetically modified to express a CD19 1XX chimeric antigen receptor (CAR) that targets the tumor-associated antigen (TAA) CD19, linked to the co-stimulatory intracellular signaling domains of CD28 and the zeta chain of the TCR (T-cell receptor)/CD3 complex (CD3-zeta) (CD28zeta; CD28z), and inserted into the T-cell receptor alpha constant (TRAC) locus and edited for elimination of TCR expression, with potential immunostimulating and antineoplastic activities. Upon administration, the allogeneic anti-CD19 1XX-CAR T-cells FT819 specifically recognize and bind to CD19-expressing tumor cells, resulting in specific T-cell-mediated tumor cell lysis. CD19 antigen is a B-cell specific cell surface antigen, which is expressed in all B-cell lineage malignancies and normal B-cells. The CD19 1XX CAR T-cells include a 1928zeta mutant, 1XX, which contains one instead of all three immunoreceptor tyrosine-based activation motifs (iTAMs). This may help prevent counterproductive T-cell differentiation and exhaustion, and may enhance the anti-tumor activity of the CAR T-cells. By nullifying the TCR, the possibility of graft versus host disease (GvHD) is eliminated."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5216270", "l": "Monocytes.abnormal|NCnc|Pt|Bld", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1148303", "l": "Basophils+Eosinophils+Monocytes", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1955941", "l": "Precursor Cells, T-Lymphoid", "d": []}, {"i": "MESH:D054504", "l": "Precursor Cells, T-Lymphoid", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1511464", "l": "CY30", "d": []}, {"i": "NCIT:C20238", "l": "CY30", "d": ["Provider: CyThera, Inc., San Diego, CA. No information from provider. This cell line meets the criteria for the use of human embryonic stem cells by federally funded researchers."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:4023181", "l": "hypendymal cell", "d": ["A neurecto-epithelial cell that is part of the basal layer of the subcommissural organ and specializes in the secretion of proteins into the subarachnoid space. Hypendymal cells have similar characteristics to ependymal cells and express SCO-spondin."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5216315", "l": "Promonocytes|NCnc|Pt|Bld", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1267807", "l": "SMIg lambda+ lymphocyte", "d": []}, {"i": "SNOMEDCT:117511008", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5170980", "l": "Leukocytes+Platelets | Blood | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "ic": "76.857431420584163", "identifiers": [{"i": "CL:0002608", "l": "hippocampal neuron", "d": ["A neuron with a soma found in the hippocampus."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5170929", "l": "Leukocytes | Fetus | Blood | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C4764041", "l": "Autologous Deep IL-15 Primed T-cells TRQ15-01", "d": []}, {"i": "NCIT:C158091", "l": "Autologous Deep IL-15 Primed T-cells TRQ15-01", "d": ["A preparation of genetically modified, multi-antigen-directed autologous T-lymphocytes, that have particles, consisting of multiple chemically crosslinked human cytokine interleukin-15 (IL-15)/IL-15 receptor alpha (IL-15Ra)/Fc heterodimers, attached to their surface, with potential immunostimulating and antineoplastic activities. TRQ15-01 is made from monocyte-derived dendritic cells (moDCs) that are pulsed with peptides from multiple tumor-associated antigens (TAAs) to expand cytotoxic T-lymphocytes (CTLs) that are subsequently loaded with IL-15 particles. Upon administration of the autologous deep IL-15 primed T-cells, the IL-15/IL-15Ra fusion proteins are slowly released in vivo from the T-cells in a controlled manner and induce autocrine cytokine stimulation of the administered T-cells, thereby increasing T-cell division of the administered T-cells. The expanded T-cells target, bind to and kill tumor cells. This increases tumor cell growth inhibition by T-cells. IL-15 is a pro-survival, inflammatory cytokine and causes sustained T-cell expansion and enhanced anti-tumor activity. Compared to systemically delivered IL-15, IL-15 attached to the T-cells greatly increases target CD8 T-cell concentrations in the tumor, without significant systemic effects."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2327527", "l": "Sympathetic ganglion neuron", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5186196", "l": "Donated egg | Patient | Fertility testing", "d": []}]}
{"type": "biolink:Cell", "ic": "92.728541327098611", "identifiers": [{"i": "CL:4023000", "l": "beta motor neuron", "d": ["A motor neuron that innervates both intrafusal and extrafusal muscle fibers. Low abundancy. They control both muscle contraction and responsiveness of the sensory feedback from muscle spindles."]}]}
{"type": "biolink:Cell", "ic": "58.788005074184341", "identifiers": [{"i": "UMLS:C0018956", "l": "Hematopoietic stem cells", "d": []}, {"i": "NCIT:C12551", "l": "Hematopoietic Stem Cell", "d": ["Primitive blood cells derived from embryonic mesenchyme capable of differentiating into any of the blood cell line progenitor cells (erythroblasts, young granulocytic series cells, megakaryocytes, etc.)"]}, {"i": "MESH:D006412", "l": "Hematopoietic Stem Cells", "d": []}, {"i": "SNOMEDCT:418318001", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1955382", "l": "Spermatozoa.immature", "d": []}]}
{"type": "biolink:Cell", "ic": "92.728541327098611", "identifiers": [{"i": "CL:0000633", "l": "Hensen cell", "d": ["A tall supporting cell that is arranged in rows adjacent to the last row of outer phalangeal cells. This cell type constitutes the outer border of the organ of Corti."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C4289823", "l": "Central Memory T-Lymphocyte", "d": []}, {"i": "NCIT:C126420", "l": "Central Memory T-Lymphocyte", "d": ["Long-lived antigen-specific T-lymphocytes, which express CD45RO, L-selectin and CCR7. Upon subsequent exposure to their target antigen, these cells rapidly proliferate and differentiate into effector cells."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1280426", "l": "Entire beta Cell of islet", "d": []}, {"i": "SNOMEDCT:247867004", "d": []}]}
{"type": "biolink:Cell", "ic": "83.023198044254755", "identifiers": [{"i": "UMLS:C1511178", "l": "Bipolar neuron", "d": []}, {"i": "NCIT:C13154", "l": "Bipolar Neuron", "d": ["A nerve cell with two processes."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1179017", "l": "Endothelial cell of vein", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1440321", "l": "Cells.CD49a", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0597447", "l": "Sf9 cell line", "d": []}]}
{"type": "biolink:Cell", "ic": "92.728541327098611", "identifiers": [{"i": "CL:0001069", "l": "group 2 innate lymphoid cell", "d": ["An innate lymphoid cell that is capable of producing T-helper 2-cell associated cytokines upon stimulation."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002468", "l": "Gr1-low myeloid suppressor cell", "d": ["A myeloid suppressor cell that is Gr1-low and CD11c-positive."]}]}
{"type": "biolink:Cell", "ic": "90.82444074280258", "identifiers": [{"i": "CL:0000490", "l": "photopic photoreceptor cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2736927", "l": "Cells.CD13+HLA-DR+", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:1000706", "l": "ureter urothelial cell", "d": []}]}
{"type": "biolink:Cell", "ic": "84.128890093485552", "identifiers": [{"i": "CL:0000186", "l": "myofibroblast cell", "d": ["An animal cell that has characteristics of both a fibroblast cell and a smooth muscle cell."]}]}
{"type": "biolink:Cell", "ic": "80.17194633000733", "identifiers": [{"i": "CL:0000995", "l": "CD34-positive, CD38-positive common myeloid progenitor OR CD34-positive, CD38-positive common lymphoid progenitor", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1514137", "l": "Plant Tissue, Cells", "d": []}, {"i": "NCIT:C18945", "l": "Plant Tissue, Cells", "d": ["Tissue and cells derived from plants"]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C0229633", "l": "myeloblast", "d": []}, {"i": "NCIT:C13015", "l": "Myeloblast", "d": ["An immature cell that represents the first stage in the granulocytic series of hematopoiesis. It is found in bone marrow and differentiates into a promyelocyte. Its nucleus is composed of very fine, evenly distributed chromatin with 2-5 nucleoli. The cytoplasm is basophilic and non-granular."]}, {"i": "SNOMEDCT:15622002", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0552639", "l": "tubular cells", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5569916", "l": "Transitional cells.deep", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5420525", "l": "Allogeneic PD-L1 Tumor-targeted High-affinity Natural Killer Cells", "d": []}, {"i": "NCIT:C174011", "l": "Allogeneic PD-L1 Tumor-targeted High-affinity Natural Killer Cells", "d": ["A preparation of natural killer (NK) cells that are derived from NK-92 cells, a human cytotoxic cell line composed of allogeneic NK cells derived from a 50-year old male patient with rapidly progressive non-Hodgkin's lymphoma (NHL), that are genetically engineered to express the high-affinity CD16/FcgammaRIIIa (158V) allele, endoplasmic reticulum (ER)-retained interleukin (IL)-2 and a chimeric antigen receptor (CAR) specific for programmed death-ligand 1 (PD-L1), with potential immunomodulating, cytolytic and antineoplastic activities. Upon infusion of the PD-L1 tumor-targeted high-affinity (ha) NK cells, the NK cells recognize and bind to tumor cells, preferentially to PD-L1-expressing tumor cells and human peripheral myeloid-derived suppressor cells (MDSCs). This leads to the secretion and release of perforins, granzymes, cytokines and chemokines, and results in cancer cell lysis and apoptosis. In addition, the incorporation of the high-affinity CD16 allele allows the NK cells to lyse tumor cells via antibody-dependent cell-mediated cytotoxicity (ADCC) mediated by tumor-antigen-specific immunoglobulin G1 (IgG1) antibodies through binding of CD16 with the Fc region of human IgG1 antibodies. IL-2 replenishes the granular stock of NK cells, leading to enhanced perforin- and granzyme-mediated lysis of tumor cells."]}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "CL:2000002", "l": "decidual cell", "d": ["A specialized, enlarged, connective tissue cell of the decidua with enlarged nucleus, dense membrane‐bound secretory granules and cytoplasmic accumulation of glycogen and lipid droplets. These cells develop by the transformation of endometrial stromal cells during decidualization."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4322668", "l": "CD3-CD16+CD56+ NK lymphocyte", "d": []}]}
{"type": "biolink:Cell", "ic": "59.608587053501218", "identifiers": [{"i": "CL:0000764", "l": "erythroid lineage cell", "d": ["A immature or mature cell in the lineage leading to and including erythrocytes."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157511", "l": "CD38 cells | Blood | Cell markers", "d": []}]}
{"type": "biolink:Cell", "ic": "88.140761698499901", "identifiers": [{"i": "CL:0002088", "l": "interstitial cell of Cajal", "d": ["This is a cell found in the gastrointestinal tract of mammals and serves as a pacemaker that triggers gut contraction. ICCs mediate inputs from the enteric nervous system to smooth muscle cells and are thought to be the cells from which gastrointestinal stromal tumors (GISTs) arise."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5401596", "l": "Dental Mesenchymal Pulp Stem Cells", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0432613", "l": "Eosinophilic myeloblast", "d": []}, {"i": "SNOMEDCT:259719000", "d": []}]}
{"type": "biolink:Cell", "ic": "83.023198044254755", "identifiers": [{"i": "UMLS:C1515969", "l": "Anaplastic Plasma Cell", "d": []}, {"i": "NCIT:C37081", "l": "Anaplastic Plasma Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0000929", "l": "CD4-negative, CD8-negative type I NK T cell secreting interferon-gamma", "d": ["A mature NK T cell that secretes interferon-gamma and enhances Th1 immune responses."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5555728", "l": "Allogeneic CD19-CAR CD45RA-negative T-cells", "d": []}, {"i": "NCIT:C179501", "l": "Allogeneic CD19-CAR CD45RA-negative T-cells", "d": ["A preparation of allogeneic T-lymphocytes, depleted of CD45RA-positive cells, that have been genetically modified to express a chimeric antigen receptor (CAR) targeting the tumor-associated antigen (TAA) CD19 (cluster of differentiation 19) fused to the co-stimulatory domain of 4-1BB (CD137) and the CD3-zeta (CD3z) T-cell signaling domain (4-1BBz), with potential immunostimulating and antineoplastic activities. CD45RA depletion results in a cellular product that contains a high amount of memory T-cells (Tm). Upon administration, the allogeneic CD19-CAR CD45RA-negative T-cells specifically recognize and bind to CD19-expressing tumor cells. This may result in a specific cytotoxic T-lymphocyte (CTL)-mediated killing of CD19-expressing tumor cells. CD19 antigen is a B-cell specific cell surface antigen overexpressed in B-cell lineage malignancies. CD45RA is expressed on naive T-cells (Tn), whereas Tm cells are CD45RA-negative. The depletion of the CD45RA-positive cells reduces the risk of graft-versus-host disease (GvHD) upon infusion. Tn cells have the potential to induce more severe graft-versus-host disease (GvHD) than Tm cells."]}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "CL:0002556", "l": "fibroblast of periodontium", "d": ["A fibroblast of the periodontium."]}]}
{"type": "biolink:Cell", "ic": "61.537412234791987", "identifiers": [{"i": "UMLS:C1518216", "l": "Malignant Neuroendocrine Cell", "d": []}, {"i": "NCIT:C36825", "l": "Malignant Neuroendocrine Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1709903", "l": "Renal Tumor-Reactive Autologous Peripheral Blood Lymphocyte", "d": []}, {"i": "NCIT:C48816", "l": "Renal Tumor-Reactive Autologous Peripheral Blood Lymphocyte", "d": ["Peripheral blood lymphocytes (PBL) harvested from the blood of a renal cancer patient and exposed in vitro to renal tumor-associated antigens (TAA).  Introducing these renal tumor-reactive autologous peripheral blood lymphocytes back to the same patient target tumor cells expressing these TAAs and could induce a cytotoxic T-cell-mediated immune response against renal cell cancer."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2350150", "l": "Pronormoblasts", "d": []}]}
{"type": "biolink:Cell", "ic": "70.75272396535307", "identifiers": [{"i": "UMLS:C1266872", "l": "Renal tubular epithelial cell", "d": []}, {"i": "NCIT:C61147", "l": "Renal Tubular Epithelial Cell", "d": []}, {"i": "SNOMEDCT:117287000", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0004243", "l": "WF3-2 amacrine cell", "d": ["An amacrine cell with a wild dendritic field, dendrites in S3, and post-synaptic terminals in S3. Dendrites have spikes, cross over each other, and cover a larger volume than dendrties of W3-1 retinal amacrine cells."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C4733637", "l": "Autologous HPV-specific Cytotoxic T Lymphocytes", "d": []}, {"i": "NCIT:C155880", "l": "Autologous HPV-specific Cytotoxic T Lymphocytes", "d": ["A population of autologous cytotoxic T-lymphocytes (CTLs) that are specifically reactive to human papillomavirus (HPV), with potential antiviral and antineoplastic activities activities. Upon infusion of the autologous HPV-specific CTLs, these CTLs induce selective toxicity in HPV-positive cancer cells and other HPV-infected cells. HPV is associated with various cancer cell types."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5380989", "l": "Cells.CD8.HLA-B7 CMV specific.CMV antigen stimulated CD107a+b expressing", "d": []}]}
{"type": "biolink:Cell", "ic": "82.532694649739099", "identifiers": [{"i": "CL:4023012", "l": "near-projecting glutamatergic cortical neuron", "d": ["A glutamatergic neuron located in the cerebral cortex that projects axons locally rather than distantly."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:1000452", "l": "parietal epithelial cell", "d": ["An epithelial cell that is part of the glomerular parietal epithelium."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:1000347", "l": "enterocyte of colon", "d": ["A columnar cell of the colon that is part of the colonic epithelium."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5554901", "l": "Autologous Gamma Delta T-cell Receptor-expressing T-cells TEG002", "d": []}, {"i": "NCIT:C178253", "l": "Autologous Gamma Delta T-cell Receptor-expressing T-cells TEG002", "d": ["A preparation of autologous T-lymphocytes genetically engineered to express a defined gamma delta T-cell receptor (TCR), with potential immunomodulating and antineoplastic activities. Upon administration of the autologous gamma delta TCR-expressing T-cells TEG002, these cells secrete interferon-gamma (IFN-g) and exert direct killing of tumor cells. In addition, these cells activate the immune system to exert a cytotoxic T-lymphocyte (CTL) response against tumor cells. Gamma delta T-lymphocytes play a key role in the activation of the immune system and do not require major histocompatibility complex (MHC)-mediated antigen presentation to exert their cytotoxic effect."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1522214", "l": "Endocrine Pancreas - Islet Cell of Langerhans - Beta Cell (MMHCC)", "d": []}, {"i": "NCIT:C22642", "l": "Mouse Beta Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "92.728541327098611", "identifiers": [{"i": "CL:0001015", "l": "CD8_alpha-low Langerhans cell", "d": ["CD8_alpha-low Langerhans cell is a Langerhans cell that is CD205-high and is CD8_alpha-low."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1514732", "l": "Rat-1", "d": []}, {"i": "NCIT:C19584", "l": "Rat-1", "d": ["Fibroblasts used as an in vitro model for cell signaling studies"]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4300403", "l": "Cells.chromosome region 5q31", "d": []}]}
{"type": "biolink:Cell", "ic": "86.236661114203869", "identifiers": [{"i": "CL:0000905", "l": "effector memory CD4-positive, alpha-beta T cell", "d": ["CD4-positive, alpha-beta memory T cell with the phenotype CCR7-negative, CD127-positive, CD45RA-negative, CD45RO-positive, and CD25-negative."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1440303", "l": "Cells.CD39", "d": []}]}
{"type": "biolink:Cell", "ic": "54.63961067689295", "identifiers": [{"i": "CL:0000837", "l": "hematopoietic multipotent progenitor cell", "d": ["A hematopoietic multipotent progenitor cell is multipotent, but not capable of long-term self-renewal. These cells are characterized as lacking lineage cell surface markers and being CD34-positive in both mice and humans."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0001025", "l": "Kit-positive, Sca1-positive common lymphoid progenitor", "d": ["A common lymphoid progenitor that is Kit-low, FLT3-positive, IL7ralpha-positive, and SCA1-low."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157387", "l": "CD20+FMC7+ cells | XXX | Cell markers", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0682525", "l": "W138 cell", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:2000096", "l": "fibroblast of the reticular layer of dermis", "d": ["Any fibroblast that is part of a reticular layer of dermis."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5419626", "l": "ROBO1-targeted BiCAR-NKT Cells", "d": []}, {"i": "NCIT:C172380", "l": "ROBO1-targeted BiCAR-NKT Cells", "d": ["A preparation of natural killer T (NKT) cells engineered to express a chimeric antigen receptor (CAR) specific for roundabout homolog 1 (ROBO1, Robo1), with potential immunostimulating and antineoplastic activities. Upon administration, the ROBO1-targeted BiCAR-NK/T cells target and bind to ROBO1 expressed on the surface of tumor cells. This induces selective toxicity in ROBO1-expressing tumor cells. ROBO1, a member of the axon guidance receptor family, is often overexpressed in a variety of tumor types. It is involved in axon guidance, cell proliferation, cell motility and angiogenesis."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0009093", "l": "smooth muscle cell of placenta", "d": ["A smooth muscle cell that is part of a placenta."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5170901", "l": "Leukemia markers | Pleural fluid | Cell markers", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0229609", "l": "Secretory macrophage", "d": []}, {"i": "SNOMEDCT:35113007", "d": []}]}
{"type": "biolink:Cell", "ic": "74.516770421031836", "identifiers": [{"i": "UMLS:C1519466", "l": "Spindle Endothelial Cell", "d": []}, {"i": "NCIT:C37092", "l": "Spindle Endothelial Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0004242", "l": "WF3-1 amacrine cell", "d": ["An amacrine cell with a wide dendritic field, dendrites in S3, and post-synaptic terminals in S3. Dendrites of this cell type are straight and minimally branched."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2327878", "l": "Type S enteroendocrine cell", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C0225332", "l": "Fibrocyte", "d": []}, {"i": "NCIT:C120463", "l": "Fibrocyte", "d": ["A quiescent connective tissue cell with minimal cytoplasm and little to no evidence of protein synthesis. These cells may be able to differentiate into fibroblasts."]}, {"i": "SNOMEDCT:24735009", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0000641", "l": "chromophobe cell", "d": ["A cell that is resistant to stains."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0001045", "l": "naive CCR4-positive regulatory T cell", "d": ["A naive regulatory T cell with the phenotype CD4-positive, CD25-positive, CD127lo, CCR4-positive, and CD45RO-negative."]}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "UMLS:C1709207", "l": "Neoplastic Striated Muscle Cell with Eosinophilic Granular Cytoplasm", "d": []}, {"i": "NCIT:C49170", "l": "Neoplastic Striated Muscle Cell with Eosinophilic Granular Cytoplasm", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0949432", "l": "TC2 Cells", "d": []}]}
{"type": "biolink:Cell", "ic": "63.119211224969447", "identifiers": [{"i": "UMLS:C1513956", "l": "Neoplastic Endothelial Cell", "d": []}, {"i": "NCIT:C37088", "l": "Neoplastic Endothelial Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "90.82444074280258", "identifiers": [{"i": "CL:0002485", "l": "retinal melanocyte", "d": ["A melanocyte of the retina. This cell type is distinct from pigmented retinal epithelium."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5401605", "l": "Human umbilical cord blood mononuclear cell-conditioned medium", "d": []}]}
{"type": "biolink:Cell", "ic": "58.893485663852978", "identifiers": [{"i": "CL:0001035", "l": "bone cell", "d": ["A connective tissue cell found in bone."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1440052", "l": "Abnormal blood cells.CD2", "d": []}]}
{"type": "biolink:Cell", "ic": "83.552982069901191", "identifiers": [{"i": "CL:0002354", "l": "yolk sac hematopoietic stem cell", "d": ["A hematopoietic stem found in the yolk sac. In mice, this cell type is Sca-1-negative, CD45-negative, MHC-negative, HSA-positive, AA4.1-positive, CD44-positive."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4511888", "l": "Population of all atypical lymphocytes in portion of fluid", "d": []}, {"i": "SNOMEDCT:726506006", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1148382", "l": "Monocytes+Macrophages", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4518166", "l": "Population of all spermatozoa with duplicate head in portion of fluid", "d": []}, {"i": "SNOMEDCT:725247001", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:1000717", "l": "kidney outer medulla collecting duct intercalated cell", "d": ["Intercalated cell that is part of some outer medullary collecting duct. It is known in some mammalian species that this cell may contribute in the maintenance of acid/base homeostasis."]}]}
{"type": "biolink:Cell", "ic": "90.82444074280258", "identifiers": [{"i": "CL:1000398", "l": "endothelial cell of hepatic sinusoid", "d": ["An endothelial cell that is part of the hepatic sinusoid. These cells possess flattened areas containing perforations about 0.1 micrometers in diameter, known as fenestrae. The fenestrae are arranged in groups known as sieve plates."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1179683", "l": "Mucous cell of stomach", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0333739", "l": "Pinocytotic cell", "d": []}, {"i": "SNOMEDCT:57852008", "d": []}]}
{"type": "biolink:Cell", "ic": "77.271239091128209", "identifiers": [{"i": "CL:0000453", "l": "Langerhans cell", "d": ["Langerhans cell is a conventional dendritic cell that has plasma membrane part CD207. A Langerhans cell is a stellate dendritic cell of myeloid origin, that appears clear on light microscopy and has a dark-staining, indented nucleus and characteristic inclusions (Birbeck granules) in the cytoplasm; Langerhans cells are found principally in the stratum spinosum of the epidermis, but they also occur in other stratified epithelia and have been identified in the lung, lymph nodes, spleen, and thymus."]}]}
{"type": "biolink:Cell", "ic": "49.576571653722809", "identifiers": [{"i": "CL:0000100", "l": "motor neuron", "d": ["An efferent neuron that passes from the central nervous system or a ganglion toward or to a muscle and conducts an impulse that causes or inhibits movement."]}]}
{"type": "biolink:Cell", "ic": "51.19735403711578", "identifiers": [{"i": "CL:0000125", "l": "glial cell", "d": ["A non-neuronal cell of the nervous system. They not only provide physical support, but also respond to injury, regulate the ionic and chemical composition of the extracellular milieu. Guide neuronal migration during development, and exchange metabolites with neurons."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C3900006", "l": "Autologous Anti-CD19CAR-4-1BB-CD3zeta-EGFRt-expressing T Lymphocytes", "d": []}, {"i": "NCIT:C116914", "l": "Autologous Anti-CD19CAR-4-1BB-CD3zeta-EGFRt-expressing T Lymphocytes", "d": ["A preparation of genetically modified CD8+ central memory (Tcm) and CD4+ autologous T-lymphocytes (1:1) transduced with a replication incompetent, self-inactivating (SIN) lentiviral vector expressing a chimeric antigen receptor (CAR) containing an anti-CD19 single chain variable fragment (scFv) derived from the murine IgG1 monoclonal antibody (mAb) FMC63, fused to the signaling domain of 4-1BB (CD137), the zeta chain of the TCR/CD3 complex (CD3-zeta), and a truncated form of the human epidermal growth factor receptor (EGFRt), with potential immunostimulating and antineoplastic activities. Upon intravenous administration, autologous anti-CD19CAR-4-1BB-CD3zeta-EGFRt-expressing T lymphocytes are directed to and induce selective toxicity in CD19-expressing tumor cells. CD19 antigen is a B-cell specific cell surface antigen expressed in all B-cell lineage malignancies. Devoid of both ligand binding domains and tyrosine kinase activity, the expressed EGFRt both facilitates in vivo detection of the administered, transduced T-cells and can promote elimination of those cells through a cetuximab-induced antibody dependent cellular cytotoxicity response. The 4-1BB costimulatory signaling domain enhances both proliferation of T-cells and antitumor activity."]}]}
{"type": "biolink:Cell", "ic": "87.120474278337809", "identifiers": [{"i": "CL:0002262", "l": "endothelial cell of sinusoid", "d": ["An endothelial cell that lines any of the venous cavities through which blood passes in various glands and organs such as the spleen and liver."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2337273", "l": "Transitional myocyte of atrial septal branch of anterior internodal tract", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0009062", "l": "germinal center T cell", "d": ["A specialized type of CD4 positive T cell, the follicular helper T cell (TFH cell), that upregulates CXCR5 expression to enable its follicular localization. These specialised T cells reside in the germinal center of the lymph node."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0947288", "l": "Cell positive for CD71 antigen", "d": []}, {"i": "SNOMEDCT:116830006", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1276861", "l": "Entire endometrial glandular cell", "d": []}, {"i": "SNOMEDCT:254032002", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1510781", "l": "Adenocarcinoma Cell with Intranuclear Inclusion", "d": []}, {"i": "NCIT:C36876", "l": "Adenocarcinoma Cell with Intranuclear Inclusion", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1440270", "l": "Cells.CD1a", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5216257", "l": "Macrophages|NCnc|Pt|Pericard fld", "d": []}]}
{"type": "biolink:Cell", "ic": "80.511444690059548", "identifiers": [{"i": "UMLS:C1517715", "l": "Lacunar Reed-Sternberg Cell", "d": []}, {"i": "NCIT:C37023", "l": "Lacunar Reed-Sternberg Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5206588", "l": "Autologous c-Met/PD-L1-specific CAR T-cells", "d": []}, {"i": "NCIT:C162481", "l": "Autologous c-Met/PD-L1-specific CAR T-cells", "d": ["A preparation of autologous T-lymphocytes that have been transduced with a lentiviral vector encoding a chimeric antigen receptor (CAR) specific for human hepatocyte growth factor receptor (HGFR or c-Met) and the immunosuppressive ligand, programmed cell death-1 ligand 1 (PD-L1; cluster of differentiation 274; CD274), with potential antineoplastic activities. Upon infusion, the autologous c-Met/PD-L1-specific CAR T-cells bind to and induce selective toxicity in c-Met- and PD-L1-expressing tumor cells. cMET, a receptor tyrosine kinase that is overexpressed or mutated in many tumor cell types, plays a key role in cancer cell growth, survival, angiogenesis, invasion, and metastasis. PD-L1 is also overexpressed by many human cancer cell types and plays a key role in the downregulation of the immune system and tumor evasion from host immunity."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1267861", "l": "Lymphoblast positive for CD10 antigen", "d": []}, {"i": "SNOMEDCT:117543008", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157286", "l": "CD126 blasts | Blood | Cell markers", "d": []}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "CL:0000828", "l": "thromboblast", "d": ["A progenitor cell of the thrombocyte, a nucleated blood cell involved in coagulation typically seen in birds and other non-mammalian vertebrates."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1267846", "l": "Lymphocyte positive for CD5 antigen and negative for CD2 antigen", "d": []}, {"i": "SNOMEDCT:117533005", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5163438", "l": "Eosinophils | Cerebral spinal fluid | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "ic": "34.889241718715965", "identifiers": [{"i": "CL:0000211", "l": "electrically active cell", "d": ["A cell whose function is determined by the generation or the reception of an electric signal."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0000741", "l": "spinal accessory motor neuron", "d": ["A motor neuron that is located in the cervical region of the spinal cord and selectively innervates the sternocleidmastoid or trapezius muscle. Unlike other motor neurons, they extend axons dorsally along lateral margins of the spinal cord."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002448", "l": "Ly49H-negative natural killer cell, mouse", "d": ["A NK1.1-positive T cell that is Ly49H-negative."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002030", "l": "Fc-epsilon RIalpha-high basophil progenitor cell", "d": ["A lineage negative, Sca1-negative basophil progenitor cell that is Fc epsilon RIalpha-high."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157291", "l": "CD127 blasts | XXX | Cell markers", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1883178", "l": "Subclone", "d": []}, {"i": "NCIT:C62037", "l": "Subclone", "d": ["A DNA clone generated by transferring a cloned DNA fragment from one plasmid to another."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1280425", "l": "Entire alpha Cell of islet", "d": []}, {"i": "SNOMEDCT:247770008", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0483183", "l": "CD16-CD57-", "d": []}]}
{"type": "biolink:Cell", "ic": "92.728541327098611", "identifiers": [{"i": "CL:1000325", "l": "jejunal goblet cell", "d": ["A goblet cell that is part of the epithelium proper of jejunum."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0000361", "l": "gastrula cell", "d": ["A cell of the embryo in the early stage following the blastula, characterized by morphogenetic cell movements, cell differentiation, and the formation of the three germ layers."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:1000702", "l": "kidney pelvis smooth muscle cell", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:4030015", "l": "kidney collecting duct alpha-intercalated cell", "d": ["A renal alpha-intercalated cell that is part of the collecting duct of the renal tubule."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C4726563", "l": "Autologous E6 T Cell Receptor Genetically-modified T Cells", "d": []}, {"i": "NCIT:C151936", "l": "Autologous E6 T Cell Receptor Genetically-modified T Cells", "d": ["A preparation of human autologous peripheral blood lymphocytes (PBLs) that have been genetically engineered to express a T-cell receptor (TCR) that specifically targets the viral oncoprotein human papillomavirus type 16 (HPV-16) E6, with potential antineoplastic activity. Upon administration, the HPV E6 TCR genetically-modified T-cells target and bind to HPV-16 E6-expressing tumor cells, which leads to specific cytotoxic T-lymphocyte (CTL)-mediated killing of HPV-16 E6-positive tumor cells. HPV-16 E6, a cell surface glycoprotein, plays a key role in the tumorigenesis of various HPV-associated tumors and is absent from healthy human tissues."]}]}
{"type": "biolink:Cell", "ic": "88.140761698499901", "identifiers": [{"i": "CL:2000031", "l": "lateral line ganglion neuron", "d": ["Any neuron that is part of a lateral line ganglion."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:4033052", "l": "ON parasol ganglion cell", "d": ["A parasol ganglion cell that depolarizes in response to increased light intensity in the center of its receptive field. The majority of input that this cell receives comes from DB4 bipolar cells."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002603", "l": "astrocyte of the cerebellum", "d": ["An astrocyte of the cerebellum."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C0229655", "l": "monoblast", "d": []}, {"i": "NCIT:C13014", "l": "Monoblast", "d": ["A cell derived from a myeloid progenitor cell. It differentiates into a promonocyte. It is about 12 to 20 micrometer in diameter, has a round to oval nucleus with fine, lightly dispersed chromatin and one to four nucleoli. The cytoplasm is agranular, stains moderately to lightly basophilic, and often has an intensely stained periphery and a prominent perinuclear zone. Monoblasts are found in bone marrow and never appear in the normal peripheral blood."]}, {"i": "SNOMEDCT:53945006", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4304496", "l": "Population of all sickle cells in portion of fluid", "d": []}, {"i": "SNOMEDCT:719692009", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1545464", "l": "Cells.t(2;13)(q36.1;q14.4)(PAX3,FOXO1)", "d": []}]}
{"type": "biolink:Cell", "ic": "78.96520244130248", "identifiers": [{"i": "CL:4023041", "l": "L5 extratelencephalic projecting glutamatergic cortical neuron", "d": ["A glutamatergic neuron, with a soma found in the deeper portion of L5, that has long-range axonal projections including deep subcortical targets outside of the telencephalon and, in some cases, the spinal cord. While the L5 ET neuron projections are not limited to ET targets, they are clearly differentiated from the neuron subclasses whose projections are constrained to intratelencephalic (IT) targets.  L5 ET neurons are generally the largest excitatory cortical neurons, typically having a thick apical dendrite with a prominent dendritic tuft in layer 1 and displaying burst-firing physiological characteristics."]}]}
{"type": "biolink:Cell", "ic": "79.541110464886842", "identifiers": [{"i": "CL:0008046", "l": "extrafusal muscle fiber", "d": ["A skeletal muscle fiber that is innervated by alpha motor neuron and generates tension by contracting, thereby allowing for skeletal movement. These fibers make up the large mass of skeletal muscle tissue and are attached to bones by tendons."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C4085961", "l": "Anti-CD133-CAR Vector-transduced Allogeneic T Lymphocytes", "d": []}, {"i": "NCIT:C124132", "l": "Anti-CD133-CAR Vector-transduced Allogeneic T Lymphocytes", "d": ["A preparation of allogeneic peripheral blood T-lymphocytes (PBTL) that have been genetically modified to express a chimeric antigen receptor (CAR) specific for the chimeric CD (cluster of differentiation) 133 antigen receptor, with potential immunostimulating and antineoplastic activities. Upon administration, anti-CD133-CAR vector-transduced allogeneic T-lymphocytes specifically recognize and kill CD133-expressing tumor cells. CD133, a tumor associated antigen (TAA), is overexpressed on a variety of tumor cell types."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5706508", "l": "AVR-RD-01", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5154477", "l": "Basophils | Cerebral spinal fluid | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0206152", "l": "Cell Transplants", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1184142", "l": "Luminal cell of lactiferous duct", "d": []}]}
{"type": "biolink:Cell", "ic": "74.659114980698789", "identifiers": [{"i": "CL:0000748", "l": "retinal bipolar neuron", "d": ["A bipolar neuron found in the retina and having connections with photoreceptors cells and neurons in the inner plexiform layer."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2734107", "l": "Erythrocytes+Granulocytes.CD55+CD59 deficient", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5555589", "l": "Autologous Anti-ALPP CAR Retroviral Vector-transduced T Cells", "d": []}, {"i": "NCIT:C179291", "l": "Autologous Anti-ALPP CAR Retroviral Vector-transduced T Cells", "d": ["A preparation of autologous T lymphocytes that have been transduced with a retroviral vector expressing a chimeric antigen receptor (CAR) targeting alkaline phosphatase, placental type (ALPP; placental alkaline phosphatase; PLAP), with potential immunostimulating and antineoplastic activities. Upon infusion back into the patient, autologous anti-ALPP CAR retroviral vector-transduced T cells target and bind to ALPP-expressing tumor cells, thereby inducing selective toxicity in ALPP-expressing tumor cells. ALPP, mainly expressed in placenta and testis, is overexpressed on certain tumor cell types, such as on a proportion of colorectal cancers while not expressed in any other normal tissues. It plays a key role in tumor cell proliferation."]}]}
{"type": "biolink:Cell", "ic": "92.728541327098611", "identifiers": [{"i": "CL:0002080", "l": "pancreatic centro-acinar cell", "d": ["A cubodial epithelial cell that is continuous with the lining of intercalated ducts that drain the acinus. This cell type secretes a high pH solution to aid in activation of zymogens, and can differentiate into endocrine and exocrine pancreatic cell types."]}]}
{"type": "biolink:Cell", "ic": "78.185623981295834", "identifiers": [{"i": "CL:0002064", "l": "pancreatic acinar cell", "d": ["A secretory cell found in pancreatic acini that secretes digestive enzymes and mucins. This cell is a typical zymogenic cell, have a basal nucleus and basophilic cytoplasm consisting of regular arrays of granular endoplasmic reticulum with mitochondria and dense secretory granules."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0443780", "l": "Rhytiocyte", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1440330", "l": "Cells.CD51", "d": []}]}
{"type": "biolink:Cell", "ic": "88.140761698499901", "identifiers": [{"i": "CL:4023025", "l": "long-range projecting sst GABAergic cortical interneuron (Mmus)", "d": ["A sst GABAergic cortical interneuron that is both an interneuron and a projecting neuron. They are found in all layers from upper L2/3 down to the bottom of L6. They have long-range projections, some with axons fading into white matter. These cells have low rebound potential, low hyperpolarization sag, and high variability in membrane time constant."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2936608", "l": "Side-Population Cells", "d": []}, {"i": "MESH:D058985", "l": "Side-Population Cells", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5205544", "l": "Autologous Anti-CD19/Anti-CD20-CAR-CD28-4-1BB-CD3zeta-EGFRt+-expressing Tn/mem Cells", "d": []}, {"i": "NCIT:C160777", "l": "Autologous Anti-CD19/Anti-CD20-CAR-CD28-4-1BB-CD3zeta-EGFRt+-expressing Tn/mem Cells", "d": ["A preparation of genetically modified autologous naive/memory T-cells (Tn/mem),  that have been transduced with a self-inactivating (SIN) lentiviral vector to express a bispecific chimeric antigen receptor (CAR) consisting of a single chain variable fragment (scFv) of anti-CD19, derived from the anti-CD19 monoclonal antibody FMC63, in tandem with an anti-CD20 scFv, derived from the anti-CD20 monoclonal antibody Leu16, and fused to the hinge domain of human immunoglobulin (Ig) G4, the transmembrane domain of human CD28, and the cytoplasmic signaling domains of 4-1BB (CD137) and the T-cell antigen receptor complex zeta chain (CD3-zeta) (BBz), and linked via the T2A sequence to a truncated form of the human epidermal growth factor receptor (EGFRt), with potential immunostimulating and antineoplastic activities. Upon transfusion, autologous anti-CD19/anti-CD20-CAR-CD28-4-1BB-CD3zeta-EGFR+-expressing Tn/mem cells recognize and induce selective toxicity in CD19/CD20-expressing tumor cells, resulting in tumor cell lysis. Both CD19 and CD20 are B-cell-specific cell surface antigens overexpressed in B-cell lineage malignancies. Devoid of both ligand binding domains and tyrosine kinase activity, EGFRt both facilitates in vivo detection of the administered T-cells and can promote elimination of those cells upon a cetuximab-induced antibody dependent cellular cytotoxicity (ADCC) response."]}]}
{"type": "biolink:Cell", "ic": "63.561493752554874", "identifiers": [{"i": "CL:0000147", "l": "pigment cell", "d": ["A pigment cell is a cell that contains pigment granules."]}]}
{"type": "biolink:Cell", "ic": "35.626832766036536", "identifiers": [{"i": "CL:0000540", "l": "neuron", "d": ["The basic cellular unit of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the nervous system."]}]}
{"type": "biolink:Cell", "ic": "72.577556932535018", "identifiers": [{"i": "UMLS:C1513931", "l": "Neoplastic Basaloid Cell", "d": []}, {"i": "NCIT:C36759", "l": "Neoplastic Basaloid Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "86.236661114203869", "identifiers": [{"i": "CL:1001320", "l": "urethra cell", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C4725094", "l": "EPS8 Peptide-specific Dendritic Cells", "d": []}, {"i": "NCIT:C148518", "l": "EPS8 Peptide-specific Dendritic Cells", "d": ["A preparation of dendritic cells (DCs) pulsed with peptides derived from epidermal growth factor receptor (EGFR) pathway substrate 8 (EPS8), with potential immunostimulating and antineoplastic activities. Upon administration of the EPS8 peptide-specific DCs, the immune system is exposed to the EPS8 antigens. This results in the induction of a specific cytotoxic T-lymphocyte (CTL) response against EPS8-expressing tumor cells and tumor cell lysis. EPS8, a tumor-associated antigen (TAA), is overexpressed in a variety of tumor cell types but rarely in normal tissues. As a substrate for the EGFR kinase, it plays a key role in tumor progression through the EGFR-dependent pathway. Its expression is correlated with a poor prognosis."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5177619", "l": "Platelets | Bone marrow | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1268011", "l": "Immature plasma cell", "d": []}, {"i": "SNOMEDCT:117293008", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:1000442", "l": "urothelial cell of trigone of urinary bladder", "d": ["An urothelial cell that is part of the trigone of urinary bladder."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0882801", "l": "Cells.CD16+CD57+/100 cells", "d": []}]}
{"type": "biolink:Cell", "ic": "89.347505587204751", "identifiers": [{"i": "CL:0002324", "l": "myoepithelial cell of mammary gland", "d": ["A myoepithelial cell that surrounds milk-secreting luminal epithelial cells. This cell type contracts under the stimulation of oxytocin and is attached to the basement membrane by hemidesmosomes and to the adjacent luminal cells by desmosomes. This cell type expresses high level of keratin-14 and is estrogen receptor alpha negative."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4524369", "l": "CD19CAR-CD28-CD3zeta-EGFRt-expressing Tcm-enriched T-lymphocytes", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1717525", "l": "Acute leukemia markers", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4296891", "l": "L cell, Glucagon-like peptide-producing and PP/PYY-producing NETs", "d": []}]}
{"type": "biolink:Cell", "ic": "90.82444074280258", "identifiers": [{"i": "CL:0000671", "l": "centripetally migrating follicle cell", "d": ["A follicle cell that migrates from the dorso-anterior part of the oocyte associated follicular epithelium, in between the nurse cells and the oocyte, and participates in the formation of the operculum."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1182788", "l": "Epithelial cell of glomerular capsule", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C4724838", "l": "iC9-GD2-CAR-CD28-OX40-expressing Autologous NKT Cells", "d": []}, {"i": "NCIT:C148135", "l": "iC9-GD2-CAR-CD28-OX40-expressing Autologous NKT Cells", "d": ["A preparation of autologous interleukin-15 (IL-15)-expressing natural killer T-cells (NKT) transduced with a retroviral vector encoding a chimeric antigen receptor (CAR) derived from the antibody 14G2a that recognizes disialoganglioside GD2 (GD2-CAR) that is coupled to the co-stimulatory domains of CD28 and OX40 (CD134), and to the zeta chain of the TCR/CD3 complex (CD3-zeta), and linked to the suicide gene inducible caspase 9 (iCasp9 or iC9), with potential immunomodulating and antineoplastic activities. Upon transfusion, the iC9-GD2-CAR-CD28-OX40-expressing autologous NKT cells recognize, bind to and induce selective cytotoxicity in GD2-expressing tumor cells. The tumor-associated antigen (TAA) GD2 is overexpressed on the surface of neuroblastoma cells and by other neuroectoderm-derived neoplasms, while it is minimally expressed on normal, healthy cells. The iCasp9 safety switch consists of a full-length caspase 9, including its caspase recruitment domain, linked to a human FK506 drug-binding domain with an F36V mutation (FKBP12-F36V). If the administered NKT cells lead to unacceptable side effects, the chemical homodimerizer AP1903, which binds to the FKBP12-F36V drug-binding domain, activates caspase 9, and results in apoptosis of the administered NKT cells, can be administered."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1513815", "l": "NC02", "d": []}, {"i": "NCIT:C20282", "l": "NC02", "d": ["Provider: National Centre for Biological Sciences/ Tata Institute of Fundamental Research, Bangalore, India. No information from provider. This cell line meets the criteria for the use of human embryonic stem cells by federally funded researchers."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5174120", "l": "Myeloperoxidase cells | Body fluid | Cell markers", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C3827031", "l": "Activated Marrow Infiltrating Lymphocytes", "d": []}, {"i": "NCIT:C111759", "l": "Activated Marrow Infiltrating Lymphocytes", "d": ["A preparation of cells, which consists of autologous marrow infiltrating lymphocytes (MILs), that are manipulated in vitro, with potential antitumor and immune stimulating activities. MILs are harvested from autologous bone marrow from multiple myeloma patients and, in vitro, are exposed to and activated by anti-CD3/anti-CD28 monoclonal antibodies covalently attached to super-paramagnetic microbeads. After removal of the beads and expansion of the cells in culture, the activated MILs (aMILs) are re-introduced into the patient. The aMILs possess enhanced myeloma specificity, and are able to infiltrate the tumor microenvironment and initiate tumor cell lysis. CD3 and CD28, co-stimulatory molecules expressed on the surface of T-lymphocytes, play a key role in the activation of T-cells."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:1000483", "l": "Purkinje myocyte of internodal tract", "d": ["A Purkinje myocyte that is part of the internodal tract."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0229660", "l": "Promyelomonocyte", "d": []}, {"i": "SNOMEDCT:68936005", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1440305", "l": "Cells.CD4+CD8+", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:4030006", "l": "fallopian tube secretory epithelial cell", "d": ["An epithelial cell that is part of the fallopian tube epithelium that secretes mucous fluid and oviduct-specific products through the stimulation of estrogen and luteinizing hormone. The fallopian tube secretory cell has approximately the same height as the ciliated cell and is usually a more narrow columnar cell. The nucleus is ovoid and perpendicular to the long axis of the cell. The chromatin is more dense and the nucleolus smaller than that seen in the ciliated cell."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0004238", "l": "asymmetric bistratified amacrine cell", "d": ["A bistratified amacrine cell with a medium dendritic field, a flat and sparse dendritic arbor, and post-synaptic terminals at the intersections of S1 and S2, and S3 and S4."]}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "CL:0010015", "l": "coronet cell", "d": ["A highly specialized cell type exclusive to and forming neuroepithelium of the Saccus vasculosus, covering the caudal diverticulum of the infundibular recess."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5163541", "l": "Epithelial cells | Stool | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "ic": "72.79108406015925", "identifiers": [{"i": "UMLS:C1513924", "l": "Neoplastic Acinar Cell", "d": []}, {"i": "NCIT:C36943", "l": "Neoplastic Acinar Cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157437", "l": "CD3+CD4+ (T4 helper) cells | Cerebral spinal fluid | Cell markers", "d": []}]}
{"type": "biolink:Cell", "ic": "63.507900205332078", "identifiers": [{"i": "UMLS:C1514109", "l": "Neoplastic T-Lymphocyte", "d": []}, {"i": "NCIT:C38641", "l": "Neoplastic T-Lymphocyte", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5216229", "l": "Leukocytes other|NCnc|Pt|Synv fld", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5174626", "l": "Neutrophils | Urine | Urinalysis", "d": []}]}
{"type": "biolink:Cell", "ic": "92.728541327098611", "identifiers": [{"i": "CL:0000868", "l": "lymph node macrophage", "d": ["A secondary lymphoid organ macrophage found in a lymph node. This cell is CD169-high."]}]}
{"type": "biolink:Cell", "ic": "63.323668158560849", "identifiers": [{"i": "UMLS:C0333826", "l": "Atypical lymphoblast", "d": []}, {"i": "NCIT:C12914", "l": "Neoplastic Lymphoblast", "d": []}, {"i": "SNOMEDCT:84863008", "d": []}]}
{"type": "biolink:Cell", "ic": "84.128890093485552", "identifiers": [{"i": "UMLS:C1709205", "l": "Neoplastic Spindle Stromal Cell", "d": []}, {"i": "NCIT:C54001", "l": "Neoplastic Spindle Stromal Cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4740198", "l": "BAFF-R Cells", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1720886", "l": "Melanotrophs", "d": []}, {"i": "MESH:D052717", "l": "Melanotrophs", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C0596995", "l": "Myoblasts", "d": []}, {"i": "NCIT:C33151", "l": "Myoblast", "d": ["A muscle cell precursor. It is essential for muscle repair."]}, {"i": "MESH:D032446", "l": "Myoblasts", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1267871", "l": "Lymphoblast positive for CD13 antigen", "d": []}, {"i": "SNOMEDCT:117550007", "d": []}]}
{"type": "biolink:Cell", "ic": "65.271170648665588", "identifiers": [{"i": "CL:0000557", "l": "granulocyte monocyte progenitor cell", "d": ["A hematopoietic progenitor cell that is committed to the granulocyte and monocyte lineages. These cells are CD123-positive, and do not express Gata1 or Gata2 but do express C/EBPa, and Pu.1."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4733688", "l": "autologous tri-functional anti-CD19 CAR T cells", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1440372", "l": "Cells.CD96", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5170927", "l": "Leukocytes | Dialysis fluid peritoneal | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0000938", "l": "CD16-negative, CD56-bright natural killer cell, human", "d": ["NK cell that has the phenotype CD56-bright, CD16-negative, and CD84-positive with the function to secrete interferon-gamma but is not cytotoxic."]}]}
{"type": "biolink:Cell", "ic": "92.728541327098611", "identifiers": [{"i": "UMLS:C0682639", "l": "Memory T Cells", "d": []}, {"i": "NCIT:C104082", "l": "Memory T-Lymphocyte", "d": ["A mature T-lymphocyte that has encountered its cognate antigen and is primed to reproduce and elicit a stronger immune response upon a second encounter with the antigen. These cells are characterized by the presence CD45R0."]}, {"i": "MESH:D000091246", "l": "Memory T Cells", "d": []}]}
{"type": "biolink:Cell", "ic": "79.541110464886842", "identifiers": [{"i": "CL:0002658", "l": "glandular cell of the large intestine", "d": ["A glandular epithelial cell of the large intestine."]}]}
{"type": "biolink:Cell", "ic": "77.488267285704651", "identifiers": [{"i": "CL:0000550", "l": "polychromatophilic erythroblast", "d": ["A nucleated, immature erythrocyte in which the nucleus occupies a relatively smaller part of the cell than in its precursor, the basophilic erythroblast. The cytoplasm is beginning to acquire hemoglobin and thus is no longer a purely basophilic, but takes on acidophilic aspects, which becomes progressively more marked as the cell matures. The chromatin of the nucleus is arranged in coarse, deeply staining clumps. This cell is CD71-positive and lacks hematopoeitic lineage markers."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1517355", "l": "GE09 Cell Line", "d": []}, {"i": "NCIT:C20258", "l": "GE09", "d": ["Provider: Geron Corporation, Menlo Park, CA. No information from provider. This cell line meets the criteria for the use of human embryonic stem cells by federally funded researchers."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1257740", "l": "Swiss 3T3 Cells", "d": []}, {"i": "MESH:D041701", "l": "Swiss 3T3 Cells", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1267878", "l": "Lymphocyte positive for both CD16 antigen and CD57 antigen", "d": []}, {"i": "SNOMEDCT:116729005", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1440244", "l": "Cells.CD118", "d": []}]}
{"type": "biolink:Cell", "ic": "45.267797919140229", "identifiers": [{"i": "CL:0000222", "l": "mesodermal cell", "d": ["A cell of the middle germ layer of the embryo."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4512353", "l": "Entire secondary sclerotic mastoid cell", "d": []}, {"i": "SNOMEDCT:727109004", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1440347", "l": "Cells.CD66e", "d": []}]}
{"type": "biolink:Cell", "ic": "66.450104551419699", "identifiers": [{"i": "CL:0000014", "l": "germ line stem cell", "d": ["A stem cell that is the precursor of gametes."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0009025", "l": "mesothelial cell of colon", "d": ["A mesothelial cell that is part of the colon."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C2984201", "l": "Leukemic Apoptotic Corpse-Pulsed Autologous Dendritic Cells", "d": []}, {"i": "NCIT:C91379", "l": "Leukemic Apoptotic Corpse-Pulsed Autologous Dendritic Cells", "d": ["A cell-based cancer vaccine composed of autologous dendritic cells (DCs) pulsed with corpses of apoptotic leukemic cells, with potential immunostimulatory and antineoplastic activities. Upon vaccination, autologous dendritic cells pulsed with leukemic apoptotic corpse may activate the immune system to mount an anti-tumoral cytotoxic T-lymphocyte (CTL) response against leukemic cells expressing leukemia-associated antigens, which may result in leukemic cell lysis and inhibition of tumor cell growth. Apoptotic tumor cell corpses contain an array of tumor associated antigens (TAAs)."]}]}
{"type": "biolink:Cell", "ic": "64.768237641259716", "identifiers": [{"i": "CL:1001610", "l": "bone marrow hematopoietic cell", "d": ["Hematopoietic cells resident in the bone marrow. Include: hematopoietic stem cells (lymphoid stem cells and myeloid stem cells) and the precursor cells for thrombocytes, erythrocytes, basophils, neutrophils, eosinophils, monocytes and lymphocytes."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C4084729", "l": "Cardiac Stem Cell", "d": []}, {"i": "NCIT:C124143", "l": "Cardiac Stem Cell", "d": ["Multipotent progenitor cells that are found in the fetal and adult heart that provide the myocardium with limited regenerating capability."]}]}
{"type": "biolink:Cell", "ic": "92.728541327098611", "identifiers": [{"i": "UMLS:C1512547", "l": "Hyperchromatic Adipocyte", "d": []}, {"i": "NCIT:C36979", "l": "Hyperchromatic Adipocyte", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C4727550", "l": "Autologous ROR2-targeted CAR T-cells CCT301-59", "d": []}, {"i": "NCIT:C154277", "l": "Autologous ROR2-targeted CAR T-cells CCT301-59", "d": ["A preparation of genetically modified autologous T-lymphocytes transduced with a lentiviral vector to express a chimeric antigen receptor (CAR) targeting the receptor tyrosine kinase-like orphan receptor 2 (ROR2), with potential immunomodulatory and antineoplastic activities. After isolation, transduction, and expansion in culture, CCT301-59 cells are reintroduced into the patient and are activated within the tumor microenvironment (TME) using proprietary Conditionally Active Biologic (CAB) technology. Upon activation, CAB antibodies bind to a proprietary T-cell signaling domain, promoting T-cell recognition and killing of ROR2-expressing tumor cells. ROR2 is involved in Wnt signal transduction and is involved in tumorigenesis and progression. ROR2 expression is upregulated in certain tumor types and high levels of ROR2 expression often correlates with poor prognosis."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5416838", "l": "Autologous Non-Hematopoietic Peripheral Blood Stem Cells", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:4030004", "l": "thymic nurse cell", "d": ["A large epithelial cell found in the thymus. This cell type may internalize thymocytes through extensions of plasma membrane. The cell surface and cytoplasmic vacuoles of a thymic nurse cell express MHC Class I and MHC Class II antigens. The interaction of these antigens with a developing thymocyte determines whether the thymocyte undergoes positive or negative selection."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0684128", "l": "lymphoid megakaryocyte", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C2350467", "l": "Invariant Natural Killer T-Cells", "d": []}, {"i": "NCIT:C115216", "l": "Invariant Natural Killer T-Cell", "d": ["A natural killer T-cell subtype bearing an invariant T-cell receptor. Invariant natural killer T-cells recognize a small variety of glycolipid antigens presented in the context of CD1d. These cells play a regulatory role during an immune response by producing cytokines."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C4744687", "l": "Autologous Anti-CD22 CAR-4-1BB-TCRz-transduced T-lymphocytes CART22-65s", "d": []}, {"i": "NCIT:C156251", "l": "Autologous Anti-CD22 CAR-4-1BB-TCRz-transduced T-lymphocytes CART22-65s", "d": ["Autologous human T-lymphocytes transduced with a recombinant lentiviral vector encoding a chimeric antigen receptor (CAR) consisting of an anti-CD22 human single chain variable fragment (scFv) and linked to the co-stimulatory domain 4-1BB (CD137) coupled to the zeta chain of the TCR/CD3 complex (CD3-zeta), with potential immunostimulating and antineoplastic activities. Upon reintroduction into the patient, the autologous anti-CD22 CAR-4-1BB-TCRz -transduced T-lymphocytes CART22-65s express anti-CD22-CAR on their cell surfaces and bind to the CD22 antigen on tumor cell surfaces, resulting in lysis of CD22-expressing tumor cells. CD22, a B-lineage-restricted, transmembrane phosphoglycoprotein, is expressed on malignant B-cells."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5238365", "l": "Autologous Peripheral Blood Lymphocytes from Ibrutinib-treated Chronic Lymphocytic Leukemia Patients IOV-2001", "d": []}, {"i": "NCIT:C167208", "l": "Autologous Peripheral Blood Lymphocytes from Ibrutinib-treated Chronic Lymphocytic Leukemia Patients IOV-2001", "d": ["A preparation of autologous peripheral blood lymphocytes (PBLs) harvested from chronic lymphocytic leukemia (CLL) patients previously treated with the Brutons' tyrosine kinase (BTK) inhibitor ibrutinib with potential immunostimulating and antineoplastic activities. Upon intravenous administration, IOV-2001 generates an enhanced cytotoxic T-cell response against autologous leukemic B-cells in patients who have relapsed during treatment with ibrutinib. IOV-2001 is mostly comprised of T-cells of which the majority are of the effector memory phenotype which augments the specificity of the immune response."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C4744703", "l": "Autologous Anti-BCMA-CAR-TCRz/4-1BB-expressing T-lymphocytes CART-BCMA", "d": []}, {"i": "NCIT:C156272", "l": "Autologous Anti-BCMA-CAR-TCRz/4-1BB-expressing T-lymphocytes CART-BCMA", "d": ["A preparation of autologous T-lymphocytes that have been ex vivo transduced with a genetically-engineered lentiviral vector (LV) expressing a chimeric antigen receptor (CAR) containing an extracellular human single chain variable fragment (scFv) specific for the tumor-associated antigen (TAA) human B-cell maturation antigen (BCMA; tumor necrosis factor receptor superfamily member 17; TNFRSF17) fused to an intracellular tandem signaling domain comprised of the co-stimulatory domain of 4-1BB (CD137) and the zeta chain of the T-cell receptor (TCR)/CD3 complex (CD3z), with potential immunostimulating and antineoplastic activities. Upon administration, autologous anti-BCMA-CAR-4-1BB-CD3zeta-expressing T-lymphocytes specifically recognize and induce selective toxicity in BCMA-expressing tumor cells. BCMA, a tumor-specific antigen and a receptor for both a proliferation-inducing ligand (APRIL) and B-cell activating factor (BAFF), is a member of the tumor necrosis factor receptor superfamily (TNFRSF) and plays a key role in plasma cell survival. BCMA is found on the surfaces of plasma cells and overexpressed on malignant plasma cells."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1636284", "l": "Cord blood stem cell", "d": []}, {"i": "SNOMEDCT:419423006", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1440603", "l": "Erythrocytes.CD59 deficient", "d": []}]}
{"type": "biolink:Cell", "ic": "88.140761698499901", "identifiers": [{"i": "CL:0002404", "l": "fetal thymocyte", "d": ["A thymocyte found in the fetal thymus."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1440406", "l": "Cells.t(14;18)(q32;q21.3)(IGH,BCL2)", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1267948", "l": "Lymphocyte positive for CD56 antigen", "d": []}, {"i": "SNOMEDCT:116732008", "d": []}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "UMLS:C1711304", "l": "Malignant Somatotroph Cell", "d": []}, {"i": "NCIT:C45941", "l": "Malignant Somatotroph Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "89.347505587204751", "identifiers": [{"i": "CL:0000564", "l": "neutrophilic promyelocyte", "d": ["A promyelocyte committed to the neutrophil lineage. This cell type is GATA-1-positive, C/EBPa-positive, AML-1-positive, MPO-positive, has low expression of PU.1 transcription factor and lacks lactotransferrin expression."]}]}
{"type": "biolink:Cell", "ic": "62.292266097803903", "identifiers": [{"i": "CL:0000049", "l": "common myeloid progenitor", "d": ["A progenitor cell committed to myeloid lineage, including the megakaryocyte and erythroid lineages."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C3896917", "l": "siRNA-transfected Peripheral Blood Mononuclear Cells APN401", "d": []}, {"i": "NCIT:C116353", "l": "siRNA-transfected Peripheral Blood Mononuclear Cells APN401", "d": ["Autologous peripheral blood mononuclear cells (PBMCs) transfected ex vivo with small-interfering ribonucleic acid (siRNA) directed against the E3 ubiquitin ligase casitas B-lineage lymphoma-b gene (Cbl-b), with potential immunoactivating and antineoplastic activities. The Cbl-b gene is silenced ex vivo through the binding of Cbl-b siRNA to Cbl-b mRNA, which prevents the translation of the Cbl-b protein in T-lymphocytes. Upon infusion, the activated, Cbl-b-silenced T-lymphocytes are able to increase the production of cytokines, proliferate and activate the immune system, which leads to cancer cell eradication. Cbl-b, a negative regulator of the immune system, is mutated in a variety of cancer cell types. Its expression is inversely correlated with activation of T-lymphocytes and tumor cell eradication."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:1000299", "l": "fibroblast of connective tissue of prostate", "d": ["A fibroblast that is part of the connective tissue of prostate."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0007023", "l": "flask cell", "d": ["Epidermal cell rich in mitochondria. In amphibians, appears during metamorphosis."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157251", "l": "CD11+CD18+ cells | Blood | Cell markers", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0682526", "l": "lymphoblastoid cell line", "d": []}]}
{"type": "biolink:Cell", "ic": "63.04413933979864", "identifiers": [{"i": "UMLS:C1510719", "l": "Abnormal Endothelial Cell", "d": []}, {"i": "NCIT:C37086", "l": "Abnormal Endothelial Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "57.264146600930353", "identifiers": [{"i": "CL:0000679", "l": "glutamatergic neuron", "d": ["A neuron that is capable of some neurotansmission by glutamate secretion."]}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "UMLS:C0752062", "l": "Posterior Horn Cells", "d": []}, {"i": "NCIT:C12640", "l": "Posterior Horn Cell", "d": ["Neurons in the posterior (dorsal) horn of the spinal cord whose cell bodies and processes are confined entirely to the central nervous system. They receive collateral or direct terminations of dorsal root fibers. They send their axons either directly to anterior horn cells or to the white matter ascending and descending longitudinal fibers."]}, {"i": "MESH:D020671", "l": "Posterior Horn Cells", "d": []}]}
{"type": "biolink:Cell", "ic": "87.120474278337809", "identifiers": [{"i": "CL:0005000", "l": "spinal cord interneuron", "d": ["A CNS interneuron located in the spinal cord."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5421165", "l": "Lenzumestrocel", "d": []}, {"i": "NCIT:C175108", "l": "Lenzumestrocel", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:4023161", "l": "unipolar brush cell", "d": ["An excitatory glutamatergic interneuron found in the granular layer of the cerebellar cortex and also in the granule cell domain of the cochlear nucleus. Unipolar brush cells have a round or oval cell body with usually a single short dendrite that ends in a brush-like tuft of short dendrites unique to them known as dendrioles."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0003021", "l": "retinal ganglion cell C4", "d": ["A retinal ganglion cell C outer that has a medium dendritic field and a dense dendritic arbor."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157426", "l": "CD3 cells | Cerebral spinal fluid | Cell markers", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5706348", "l": "Anti-Claudin18.2 CAR-T Cells IM92", "d": []}, {"i": "NCIT:C187104", "l": "Anti-Claudin18.2 CAR-T Cells IM92", "d": ["A preparation of T-lymphocytes engineered to express a chimeric antigen receptor (CAR) specific for the tumor-associated antigen (TAA) Claudin18.2 (CLDN18.2; A2 isoform of claudin-18), with potential immunostimulating and antineoplastic activities. Upon administration, anti-CLDN18.2 CAR-T cells IM92 specifically recognize and induce selective toxicity in CLDN18.2-expressing tumor cells. CLDN18.2, a tight junction protein, is expressed on a variety of tumor cells, but its expression in healthy tissues is strictly confined to short-lived differentiated epithelial cells of the gastric mucosa."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2337350", "l": "Type III enteric ganglion neuron", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0000780", "l": "multinuclear odontoclast", "d": ["A specialized multinuclear osteoclast associated with the absorption and removal of cementum."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5220575", "l": "Epithelial cells.renal|Urine/Urine sed", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:1000411", "l": "endothelial cell of Peyer's patch", "d": ["An endothelial cell that is part of the small intestine Peyer's patch."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C4724836", "l": "Autologous PD-1 Antibody-expressing Mesothelin-specific CAR-T Cells", "d": []}, {"i": "NCIT:C148133", "l": "Autologous PD-1 Antibody-expressing Mesothelin-specific CAR-T Cells", "d": ["Genetically modified, autologous T-lymphocytes that express an antibody that targets the negative immunoregulatory human cell surface receptor programmed cell death protein 1 (PD-1; PDCD1; CD279) and are transduced with a gene encoding a chimeric antigen receptor (CAR) specific for the human tumor-associated antigen (TAA) mesothelin, with potential immunomodulating and antineoplastic activities. After isolation, transduction, expansion in culture, and reintroduction into the patient, the autologous PD-1 antibody expressing mesothelin specific CAR-T cells specifically target and kill mesothelin-expressing tumor cells. The anti-PD-1 expressed on the CAR-T cells binds to PD-1 expressed on T-cells and prevents the interaction of PD-1 with its ligand programmed cell death 1 ligand 1 (PD-L1, PD-1L1; CD274) expressed on cancer cells, which prevents PD-1-mediated signaling and T-cell exhaustion, enhances T-cell activation, and results in enhanced toxicity in mesothelin-expressing tumor cells. PD-1, an immunoglobulin (Ig) superfamily transmembrane protein and inhibitory receptor, negatively regulates T-cell activation and overexpression within the tumor microenvironment and inhibits T-cell function. Mesothelin, a cell surface glycoprotein involved in cell adhesion, is overexpressed in a variety of cancer cell types."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2340197", "l": "Luminal cell of lactiferous terminal ductal lobular unit", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5163551", "l": "Epithelial cells.parabasal | Vaginal | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "ic": "85.457082654197222", "identifiers": [{"i": "CL:0000959", "l": "T2 B cell", "d": ["A transitional stage B cell that has the phenotype surface IgM-positive, surface IgD-postive, CD21-positive, CD23-positive, CD62L-negative, CD93-positive and is located in the splenic B follicles. This cell type has also been described as IgM-high, CD19-positive, B220-positive, AA4-positive, and CD23-positive."]}]}
{"type": "biolink:Cell", "ic": "73.721563224321088", "identifiers": [{"i": "UMLS:C1708888", "l": "Malignant Lipocyte", "d": []}, {"i": "NCIT:C48877", "l": "Malignant Lipocyte", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4304492", "l": "Population of all granulocytes in portion of fluid", "d": []}, {"i": "SNOMEDCT:719696007", "d": []}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "CL:0002344", "l": "CD56-negative, CD161-positive immature natural killer cell, human", "d": ["A natural killer cell that is developmentally immature, has the phenotype CD34-negative, CD56-negative, CD117-positive, CD122-positive,and CD161-positive."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1440287", "l": "Cells.CD3+CD8+CD45RO+CD45RA-", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:4030003", "l": "interstitial cell of thymus", "d": ["A cell that makes up the loose connective tissue of the thymus."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1514654", "l": "RL05", "d": []}, {"i": "NCIT:C20288", "l": "RL05", "d": ["Provider: Reliance Life Sciences, Mumbai, India. No information from provider. This cell line meets the criteria for the use of human embryonic stem cells by federally funded researchers."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1268459", "l": "FMC-7+ cell", "d": []}, {"i": "SNOMEDCT:116831005", "d": []}]}
{"type": "biolink:Cell", "ic": "89.347505587204751", "identifiers": [{"i": "CL:0002634", "l": "epithelial cell of anal column", "d": ["An epithelial cell of the anal column."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1267854", "l": "Lymphocyte positive for both CD8 antigen and CD25 antigen", "d": []}, {"i": "SNOMEDCT:116735005", "d": []}]}
{"type": "biolink:Cell", "ic": "86.236661114203869", "identifiers": [{"i": "CL:4023033", "l": "OFF retinal ganglion cell", "d": ["A retinal ganglion cell that is depolarized by decreased illumination of their receptive field center."]}]}
{"type": "biolink:Cell", "ic": "68.537094497236609", "identifiers": [{"i": "UMLS:C1708370", "l": "Histiocytic and Dendritic Cell", "d": []}, {"i": "NCIT:C43251", "l": "Histiocytic and Dendritic Cell", "d": ["A grouping of hematopoietic cells derived from monocytes."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:1000693", "l": "kidney interstitial fibrocyte", "d": []}]}
{"type": "biolink:Cell", "ic": "81.247621244257502", "identifiers": [{"i": "CL:1001567", "l": "lung endothelial cell", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:2000071", "l": "mammary microvascular endothelial cell", "d": ["Any microvascular endothelial cell that is part of a breast."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0008022", "l": "endocardial cushion cell", "d": ["A mesenchymal cell of the endocardial cushion.   These cells develop via an epithelial to mesenchymal transition when endocardial cells break cell-to-cell contacts and migrate into the cardiac jelly. Cells from this population form the heart septa and valves."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4510888", "l": "Blast cell positive for CD123 antigen", "d": []}, {"i": "SNOMEDCT:724307004", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5761787", "l": "BCL-005", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1182616", "l": "Neurecto-epithelial cell", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:4023060", "l": "hippocampal CA1-3 neuron", "d": ["A neuron that has its soma located in CA1-3 of the hippocampus."]}]}
{"type": "biolink:Cell", "ic": "90.82444074280258", "identifiers": [{"i": "CL:0002385", "l": "blastoconidium", "d": ["An oblong or round asexual spore formed from conidial chains."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5380988", "l": "Cells.CD8.HLA-B8 CMV specific.CMV antigen stimulated CD107a+b expressing", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5154481", "l": "Basophils | Peritoneal fluid | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0001076", "l": "NKp46-positive innate lymphoid cell, human", "d": ["An innate lymphoid cell in the human with the phenotype NKp46-positive that is a precusor for NK cells and ILC3 cells."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4697033", "l": "Cells.IgM", "d": []}]}
{"type": "biolink:Cell", "ic": "79.541110464886842", "identifiers": [{"i": "UMLS:C0229571", "l": "Type I cell of carotid body", "d": []}, {"i": "NCIT:C36965", "l": "Glomus Cell", "d": []}, {"i": "SNOMEDCT:75737006", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1441121", "l": "Purkinje cell cytoplasmic type 2", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5417890", "l": "Autologous CD19 CAR-expressing CD4+/CD8+ T-cells MB-CART19.1", "d": []}, {"i": "NCIT:C172103", "l": "Autologous CD19 CAR-expressing CD4+/CD8+ T-cells MB-CART19.1", "d": ["A preparation of CD4+ and CD8+ autologous T-lymphocytes transduced with the lentiviral vector pLTG1563 expressing a chimeric antigen receptor (CAR) specific for the tumor-associated antigen (TAA) CD19, with potential immunostimulating and antineoplastic activities. Upon intravenous administration, the autologous CD19 CAR-expressing CD4+/CD8+ T-cells MB-CART19.1 are directed to and induce selective toxicity in CD19-expressing tumor cells. CD19 antigen is a B-cell specific cell surface antigen expressed in all B-cell lineage malignancies."]}]}
{"type": "biolink:Cell", "ic": "78.695011174409487", "identifiers": [{"i": "CL:0000459", "l": "noradrenergic cell", "d": ["A cell capable of producting norepiniphrine. Norepiniphrine is a catecholamine with multiple roles including as a hormone and a neurotransmitter. In addition, epiniphrine is synthesized from norepiniphrine by the actions of the phenylethanolamine N-methyltransferase enzyme."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C4055458", "l": "Anti-HLA-A2/NY-ESO-1 TCR-transduced Autologous T Lymphocytes", "d": []}, {"i": "NCIT:C122679", "l": "Anti-HLA-A2/NY-ESO-1 TCR-transduced Autologous T Lymphocytes", "d": ["Autologous human peripheral blood T-lymphocytes transduced with a lentiviral or retroviral vector encoding a human leukocyte antigen A2 (HLA-A2) restricted anti-cancer-testis antigen 1 (NY-ESO-1) T-cell receptor (TCR) gene, with potential antineoplastic activity. Following leukapheresis, isolation of lymphocytes, expansion ex vivo, transduction, and re-introduction into the patient, the anti-HLA-A2/NY-ESO-1 TCR-transduced autologous T lymphocytes recognize and bind to NY-ESO-1/HLA-A2-positive tumor cells. This results in cytotoxic T-lymphocyte (CTL)-mediated elimination of NY-ESO-1-positive cancer cells. NY-ESO-1, a tumor-associated antigen (TAA), is found in normal testis and on the surface of various tumor cell types."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4510911", "l": "Blast cell positive for CD33 antigen", "d": []}, {"i": "SNOMEDCT:725171003", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002177", "l": "folliculostellate cell of pars distalis of adenohypophysis", "d": ["A supporting cell of the anterior pituitary gland involved in trophic and catabolic processes; expresses a broad spectrum of cytokeratins indicative of their epithelial nature."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5708695", "l": "Allogeneic Anti-CD19/CD22 CAR-BBz T-cells", "d": []}, {"i": "NCIT:C189702", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2340053", "l": "Type EC enteroendocrine cell", "d": []}]}
{"type": "biolink:Cell", "ic": "74.37742281270377", "identifiers": [{"i": "CL:0000561", "l": "amacrine cell", "d": ["Interneuron of the vertebrate retina. They integrate, modulate, and interpose a temporal domain in the visual message presented to the retinal ganglion cells, with which they synapse in the inner plexiform layer. They lack large axons."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5186791", "l": "Lymphocytes | Fetus | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0004162", "l": "360 nm-cone", "d": ["A cone whose sensitivity measurements have an average spectral peak of 358.2 nm. These cones are described in rat."]}]}
{"type": "biolink:Cell", "ic": "68.095679833930788", "identifiers": [{"i": "CL:0011020", "l": "neural progenitor cell", "d": ["An undifferentiated cell that originates from a neural stem cell and has the capacity to generate multiple types of lineage-restricted progenitors but not to self-renew."]}]}
{"type": "biolink:Cell", "ic": "60.986321514069708", "identifiers": [{"i": "UMLS:C1518178", "l": "Malignant Epithelial Small Cell", "d": []}, {"i": "NCIT:C36795", "l": "Malignant Epithelial Small Cell", "d": ["A malignant cell of epithelial origin with a small nucleus and scant amount of cytoplasm."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2359880", "l": "Transfuse platelet concentrate", "d": []}]}
{"type": "biolink:Cell", "ic": "68.594400196502249", "identifiers": [{"i": "UMLS:C1513123", "l": "Meningothelial cell", "d": []}, {"i": "NCIT:C33095", "l": "Meningothelial Cell", "d": ["The cellular components of the meninges."]}]}
{"type": "biolink:Cell", "ic": "42.947885308904482", "identifiers": [{"i": "UMLS:C1708867", "l": "Malignant Connective and Soft Tissue Cell", "d": []}, {"i": "NCIT:C48787", "l": "Malignant Connective and Soft Tissue Cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1440391", "l": "Cells.IgG", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2333726", "l": "Type D1 enteroendocrine cell", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:4040001", "l": "chorionic girdle cell", "d": ["A horse-specific, highly invasive trophoblast cell that invades the endometrium where it forms endometrial cups."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1182620", "l": "Epithelial cell of nasolacrimal duct", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1440394", "l": "Cells.S phase", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1317187", "l": "Cells.CD10+HLA-DR+", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2953664", "l": "Type D enteroendocrine cell of epithelium proper of ileum", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C4687728", "l": "Allogeneic Double Negative T Cells", "d": []}, {"i": "NCIT:C147134", "l": "Allogeneic Double Negative T Cells", "d": ["A population of healthy, donor-derived CD4 and CD8 double-negative T-lymphocytes (DNTs), with potential immunomodulating and anti-leukemic activities. The DNTs are expanded ex vivo in order to enhance their tumor destroying potential. Upon administration of the allogeneic DNTs (DNT-UHN-1), the receptors NKG2-D type II integral membrane protein (KLRK1; NKG2D) and  DNAX accessory molecule 1 (cluster of differentiation 226; CD226; DNAM-1) expressed on the DNTs recognize and bind to their cognate ligands expressed on leukemia cells. Upon binding, the DNTs release interferon-gamma (IFN-g), thereby destroying the tumor cells. DNTs derived from peripheral blood of healthy donors appear to be effective against certain types of tumor cells, including leukemia cells, and do not attack normal hematopoietic cells. NKG2D, a member of the CD94/NKG2 family of C-type lectin-like receptors, and DNAM-1, a member of the immunoglobulin superfamily containing 2 Ig-like domains of the V-set, play a key role in natural killer cell (NK)-mediated tumor cell killing. Certain tumor cells express higher levels of NKG2D and DNAM-1 ligands on their surfaces, thereby increasing their susceptibility to DNT-mediated cell lysis."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1267840", "l": "Lymphocyte negative for CD3 antigen and positive for CD19 antigen", "d": []}, {"i": "SNOMEDCT:116734009", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002287", "l": "type IV taste receptor cell", "d": ["A rounded, mitotically active stem cell which is the source of new cells of the taste bud; located basally."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C4725796", "l": "Autologous Anti-EGFRvIII 4SCAR-IgT Cells", "d": []}, {"i": "NCIT:C150518", "l": "Autologous Anti-EGFRvIII 4SCAR-IgT Cells", "d": ["A preparation of autologous T-cells that are genetically modified to express immunoglobulins (Igs) that target the negative immunoregulatory human cell surface receptor programmed cell death protein 1 (PD-1; PDCD1; CD279) and programmed death-ligand 1 (PD-L1; CD274) and are transduced with a replication incompetent, self-inactivating lentiviral vector expressing a fourth generation chimeric antigen receptor (4SCAR) consisting of a single chain variable fragment (scFv) targeting anti-epidermal growth factor receptor variant III (EGFRvIII) that is coupled to the costimulatory signaling domains CD28, CD137, CD27 and the zeta chain of the T-cell receptor (TCR), and is fused with the suicide gene inducible caspase 9 (iCasp9), with potential immunostimulating and antineoplastic activities. Upon administration, autologous anti-EGFRvIII 4SCAR-IgT cells are directed to and induce selective toxicity in EGFRvIII-expressing tumor cells. iCasp9 consists of a human FK506 drug-binding domain with an F36V mutation (FKBP12-F36V) linked to human caspase 9. If the administered T-cells lead to unacceptable side effects, the chemical homodimerizer AP1903 can be administered. AP1903 binds to the drug binding FKBP12-F36V domain and induces activation of caspase 9, which results in the apoptosis of the administered T-cells and enhances safety of this agent. EGFRvIII, a tumor-associated antigen (TAA) encoded by an in-frame deletion of exons 2-7 in the EGFR gene, is overexpressed by a variety of cancer cell types and is not expressed by normal, healthy cells. It plays a key role in tumor cell proliferation, tumor angiogenesis and resistance to both radio- and chemotherapy. CD28, CD137 and CD27, T-cell surface-associated co-stimulatory molecules, are required for full T-cell activation and enhance both proliferation of T-cells and antitumor activity. The anti-PD-1 and anti-PD-L1 antibodies produced by the T-cells (IgT) bind to PD-1, expressed on T-cells, and its ligand PD-L1 expressed on cancer cells, respectively. This inhibits PD-1/PD-L1-mediated signaling, prevents T-cell inhibition and exhaustion, enhances T-cell activation within the tumor microenvironment (TME) and results in an enhanced T-cell-mediated immune response against and toxicity in the EGFRvIII-expressing tumor cells."]}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "UMLS:C0333836", "l": "Sea-blue histiocyte", "d": []}, {"i": "NCIT:C36733", "l": "Sea-Blue Histiocyte", "d": []}, {"i": "SNOMEDCT:39474009", "d": []}]}
{"type": "biolink:Cell", "ic": "92.728541327098611", "identifiers": [{"i": "UMLS:C1182635", "l": "Follicular cell of ovary", "d": []}, {"i": "NCIT:C32620", "l": "Follicular Ovarian Cell", "d": ["A cell located in the epithelium of the ovarian follicles."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1979636", "l": "Blasts.CD11c", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5206807", "l": "WT1/PRAME/Survivin-specific Cytotoxic T-lymphocytes", "d": []}, {"i": "NCIT:C162764", "l": "WT1/PRAME/Survivin-specific Cytotoxic T-lymphocytes", "d": ["A preparation of  cytotoxic T-lymphocytes (CTLs) specifically reactive to the tumor-associated antigens (TAAs) human Wilms tumor protein (WT1), preferentially expressed antigen of melanoma (PRAME; melanoma antigen preferentially expressed in tumors; Opa-interacting protein 4; OIP-4), and survivin (baculoviral IAP repeat-containing protein 5; BIRC5), with potential immunomodulating and antineoplastic activities. Upon collection of peripheral blood mononuclear cells (PBMCs), these cells are stimulated with antigen presenting cells (APCs) pulsed with WT1, PRAME and survivin peptides; reactive T-cells are selectively expanded. Upon administration of the WT1/PRAME/Survivin-specific CTLs, these T-cells induce a CTL-mediated response against tumor cells expressing WT1, PRAME, or survivin, leading to tumor cell lysis and inhibition of tumor cell proliferation. WT1, PRAME, and survivin, are expressed on certain tumor cell types and play key roles in tumor cell proliferation and survival."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5161838", "l": "Dacrocytes | Blood | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:2000017", "l": "fibroblast of peridontal ligament", "d": ["Any fibroblast that is part of a periodontal ligament."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5187118", "l": "Variant lymphocytes | Fetus | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5168983", "l": "Immature reticulocytes | Blood | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5426723", "l": "100 Cells.CD3-CD14-CD19+CD45+", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157485", "l": "CD33 blasts | XXX | Cell markers", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002413", "l": "mature Vgamma1.1-positive, Vdelta6.3-negative thymocyte", "d": ["A Vgamma1.1-positive, Vdelta6.3-negative thymocyte that is CD24-negative."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C3890599", "l": "Circulating Melanoma Cell", "d": []}, {"i": "NCIT:C118497", "l": "Circulating Melanoma Cell", "d": ["A melanoma-derived cell found in the peripheral blood."]}]}
{"type": "biolink:Cell", "ic": "72.170119586754993", "identifiers": [{"i": "UMLS:C1513939", "l": "Neoplastic Chondrocyte", "d": []}, {"i": "NCIT:C36983", "l": "Neoplastic Chondrocyte", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5572255", "l": "Leukocyte clumps | Body fluid | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157329", "l": "CD16+CD57- | White blood cells | Cell markers", "d": []}]}
{"type": "biolink:Cell", "ic": "92.728541327098611", "identifiers": [{"i": "CL:0002482", "l": "dermal melanocyte", "d": ["A melanocyte that produces pigment in the dermis."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C4724803", "l": "NY-ESO-1/MAGE-A4/PRAME/Survivin/SSX2-specific Autologous Cytotoxic T Lymphocytes", "d": []}, {"i": "NCIT:C118367", "l": "NY-ESO-1/MAGE-A4/PRAME/Survivin/SSX2-specific Autologous Cytotoxic T Lymphocytes", "d": ["A preparation of autologous cytotoxic T-lymphocytes (CTL) that are specifically reactive to five tumor-associated antigens (TAAs), cancer-testis antigen NY-ESO-1, melanoma-associated antigen 4 (MAGE-A4), preferentially expressed antigen in melanoma (PRAME), survivin and synovial sarcoma X breakpoint 2 (SSX2; cancer/testis antigen 5.2; CT5.2), with potential antineoplastic activity. Autologous peripheral blood mononuclear cells (PBMCs) are collected and exposed ex vivo to autologous dendritic cells (DCs) that are pulsed with pepmixes, which contain overlapping peptide libraries (15 mers overlapping by 11 amino acids) spanning the entire sequence of each of the five target antigens, and simultaneously treated with the Th1-polarizing and pro-proliferative cytokines interleukin (IL) 6 (IL-6), IL-7, IL-12 and IL-15. The treated cells are expanded in culture with IL-2 and IL-15. Upon administration of the NY-ESO-1/MAGE-A4/PRAME/survivin/SSX2-specific autologous CTLs, these cells target tumor cells expressing these TAAs, which leads to cell lysis and inhibition of cell proliferation. These five TAAs are upregulated in a variety of tumor cells and play key roles in tumor cell proliferation and survival, but are absent or minimally expressed on normal, healthy human cells."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C3658291", "l": "Adult Germline Stem Cells", "d": []}, {"i": "MESH:D000072956", "l": "Adult Germline Stem Cells", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002407", "l": "mature Vgamma2-positive thymocyte", "d": ["A thymocyte that has a T cell receptor consisting of a gamma chain containing Vgamma2 segment, and a delta chain. This cell type is CD4-negative, CD8-negative and CD24-negative."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5154474", "l": "Basophils | Blood | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "ic": "52.73376302463933", "identifiers": [{"i": "CL:0008001", "l": "hematopoietic precursor cell", "d": ["Any hematopoietic cell that is a precursor of some other hematopoietic cell type."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0427530", "l": "Lymphosarcoma cell", "d": []}, {"i": "SNOMEDCT:250289002", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1268002", "l": "Lymphocyte positive for CD128 antigen", "d": []}, {"i": "SNOMEDCT:117442001", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:1001220", "l": "arcuate vein endothelial cell", "d": []}]}
{"type": "biolink:Cell", "ic": "71.249364371823347", "identifiers": [{"i": "CL:0000097", "l": "mast cell", "d": ["A cell that is found in almost all tissues containing numerous basophilic granules and capable of releasing large amounts of histamine and heparin upon activation. Progenitors leave bone marrow and mature in connective and mucosal tissue. Mature mast cells are found in all tissues, except the bloodstream. Their phenotype is CD117-high, CD123-negative, CD193-positive, CD200R3-positive, and FceRI-high. Stem-cell factor (KIT-ligand; SCF) is the main controlling signal of their survival and development."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C0229656", "l": "Promonocyte", "d": []}, {"i": "NCIT:C13121", "l": "Promonocyte", "d": ["An immature cell of the mononuclear phagocytic system. It is the representation of one stage of monocyte development."]}, {"i": "SNOMEDCT:1075005", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0009060", "l": "marginal zone B cell of lymph node", "d": ["A mature B cell located in the marginal zone of the lymph node."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C3178867", "l": "Plant Cells", "d": []}, {"i": "MESH:D059828", "l": "Plant Cells", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C3897252", "l": "Umbilical Cord Blood-derived Natural Killer Cells", "d": []}, {"i": "NCIT:C118949", "l": "Umbilical Cord Blood-derived Natural Killer Cells", "d": ["A population of allogeneic, cytokine-differentiated, highly lytic natural killer (NK) cells derived from CD34+ cells isolated from human umbilical cord blood (UCB) with potential cytotoxic activity. CD34+ hematopoietic stem cells (HSC) are isolated from human UCB mononuclear cells, differentiated into mature, highly lytic, CD3- CD56+ NK cells, by a specific combination of cytokines that includes stem cell factor (SCF), fms-related tyrosine kinase 3 ligand (Flt3-L), interleukin-15 (IL-15) and insulin-like growth factor-1 (IGF-1), and expanded ex vivo. Upon administration, the UCB-derived NK cells may lyse cancer cells."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5448026", "l": "Autologous Anti-PSMA CAR-T Cells P-PSMA-101", "d": []}, {"i": "NCIT:C175511", "l": "Autologous Anti-PSMA CAR-T Cells P-PSMA-101", "d": ["A preparation of autologous T-cells that are enriched to be primarily stem memory T-cells (Tscm) and are transfected by electroporation with a proprietary transposon-based DNA plasmid vector (PiggyBac), encoding both a chimeric antigen receptor (CAR) based on a proprietary non-immunoglobulin scaffold molecule Centyrin (CARTyrin), which specifically recognizes the tumor-associated antigen (TAA) prostate-specific membrane antigen (PSMA), and a human-derived safety switch that can be activated by rimiducid, with potential immunostimulating and antineoplastic activities. Upon administration, autologous anti-PSMA CAR-T cells P-PSMA-101 specifically recognize and induce selective toxicity in PSMA-expressing tumor cells. Use of CARTyrin may elicit less immunotoxicity than CAR T-cells based on antibody-derived single chain variable fragments (scFv), and may allow for increased persistence and decreased exhaustion for the administered T-cells. If significant side effects occur, the safety switch mechanism can be activated by the administration of rimiducid, which results in the rapid attenuation or elimination of P-PSMA-101. PSMA is overexpressed on the surface of metastatic and hormone-refractory prostate cancer cells."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002519", "l": "interrenal epithelial cell", "d": ["An interrenal epithelial kidney cell is an epithelial cell found in the anterior kidney of teleosts fish. This cell type is arranged in layers around the posterior cardinal vein and contains many mitochondria with tubulovesicular cristae. Interrenal chromaffin cells are interspersed among the tissue layer created by this cell type."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5555768", "l": "CD8 Enriched Young Autologous Tumor-infiltrating Lymphocytes", "d": []}, {"i": "NCIT:C179557", "l": "CD8 Enriched Young Autologous Tumor-infiltrating Lymphocytes", "d": ["A preparation of autologous young tumor infiltrating lymphocytes (TILs), that are isolated from the patient's tumor tissue that are CD8 enriched and expanded ex vivo, with potential antineoplastic and immunomodulating activities. Upon administration of the CD8 enriched young autologous TILs, the TILs re-infiltrate the tumor, recognize the tumor cells and initiate tumor cell lysis. This inhibits tumor cell growth."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0008027", "l": "rod bipolar cell (sensu Mus)", "d": ["A bipolar neuron found in the retina that is synapsed by rod photoreceptor cells.  These neurons have axons that arborize and synapse to targets in inner plexiform layers 4 and 5 and depolarize in response to light."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4322830", "l": "Bone marrow-derived hemopoietic stem cell", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002582", "l": "visceral preadipocyte", "d": ["A preadipocyte that is part of visceral tissue."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:4023108", "l": "oxytocin-secreting magnocellular cell", "d": ["A magnocellular neurosecretory cell that is capable of producing and secreting oxytocin."]}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "CL:0000704", "l": "endothelial tip cell", "d": ["A specialized endothelial cell that senses extracellular signals and guides the directed growth of blood vessels."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0003043", "l": "M10 retinal ganglion cell", "d": ["A monostratified retinal ganglion cell with large soma and large dendritic field, with dense dendritic arbor."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5552711", "l": "Circulating Endothelial Cell", "d": []}, {"i": "NCIT:C178241", "l": "Circulating Endothelial Cell", "d": ["An endothelial cell found in the peripheral blood."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C4745144", "l": "Autologous CD4+/CD8+ EGFR806 Specific 4-1BB-CD3zeta-EGFRt-expressing CAR T Cells", "d": []}, {"i": "NCIT:C156883", "l": "Autologous CD4+/CD8+ EGFR806 Specific 4-1BB-CD3zeta-EGFRt-expressing CAR T Cells", "d": ["A preparation of CD4+ and CD8+ autologous T-lymphocytes transduced with a lentiviral vector expressing a chimeric antigen receptor (CAR) composed of a short chain variable fragment (scFv) binding domain derived from depatuxizumab, a human anti-epidermal growth factor receptor (EGFR) monoclonal antibody (MAb806; ABT-806), coupled to the zeta chain of the TCR/CD3 complex (CD3-zeta) and the signaling domain of 4-1BB (CD137),  and linked to a truncated form of the human epidermal growth factor receptor (EGFRt), with potential immunostimulating and antineoplastic activities. Depatuxizumab specifically targets abnormal conformational states of EGFR, including the EGFR deletion mutation variant III (EGFRvIII), and activating mutations, with very low affinity for wild-type EGFR. Upon intravenous administration, the autologous CD4+/CD8+ EGFR806 specific 4-1BB-CD3zeta-EGFRt-expressing CAR T-cells are directed to and induce selective toxicity in EGFRvIII-expressing tumor cells. Devoid of both ligand binding domains and tyrosine kinase activity, the expressed EGFRt both facilitates in vivo detection of the administered, transduced T-cells and can promote elimination of these cells through an anti-EGFR antibody-dependent cellular cytotoxicity (ADCC) response. EGFRvIII, an in-frame deletion of exons 2-7 in the EGFR gene, is overexpressed by a variety of cancer cell types but absent in normal, healthy cells. It plays a key role in tumor cell proliferation, tumor angiogenesis and resistance to both radio- and chemotherapy."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5170925", "l": "Leukocytes | Cervix | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4322733", "l": "CD56+ NK cell", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0000985", "l": "IgG plasma cell", "d": ["A fully differentiated plasma cell that secretes IgG."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2924221", "l": "Cells.CD11c-CD103+", "d": []}]}
{"type": "biolink:Cell", "ic": "42.646608770063949", "identifiers": [{"i": "UMLS:C1514098", "l": "Neoplastic Smooth Muscle Cell", "d": []}, {"i": "NCIT:C36937", "l": "Neoplastic Smooth Muscle Cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0682689", "l": "neuron type", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2330414", "l": "Collateral ganglion neuron", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0000758", "l": "type 6 cone bipolar cell (sensu Mus)", "d": ["An ON-bipolar neuron found in the retina and having connections with cone photoreceptors cells and neurons in the inner half of the inner plexiform layer. The cell has a loose, delicate axon terminal that opens in sublamina 3 of the inner plexiform layer and descends into sublamina 4."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5216279", "l": "Mononuclear cells|NCnc|Pt|CSF", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2337276", "l": "Goblet cell of epithelium of gastric cardiac gland", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5238364", "l": "Partially Engineered T-regulatory Cell Donor Graft TRGFT-201", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C4687632", "l": "Dilanubicel", "d": []}, {"i": "NCIT:C146992", "l": "Dilanubicel", "d": ["A preparation of universal, off-the-shelf, ex vivo expanded, allogeneic umbilical cord blood (UCB)-derived hematopoietic stem and progenitor cells (HSPCs) that can potentially be used to improve hematopoietic recovery after chemotherapy or hematopoietic cell transplantation (HCT).  Upon administration of dilanubicel, these cells increase and restore the number of HSPCs, which may prevent or decrease infection and other complications of chemotherapy-induced neutropenia (CIN) or cord blood transplantation."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5707037", "l": "Anti-EGFR/Anti-B7-H3 CAR-T Cells", "d": []}, {"i": "NCIT:C187337", "l": "Anti-EGFR/Anti-B7-H3 CAR-T Cells", "d": ["A preparation of T-lymphocytes that have been genetically modified to express a chimeric antigen receptor (CAR) targeting the epidermal growth factor receptor (EGFR) and the immunoregulatory protein B7-homologue 3 (B7-H3, CD276), with potential immunostimulating and antineoplastic activities. Upon administration, the anti-EGFR/anti-B7-H3 CAR-T cells target and bind to EGFR-expressing tumor cells and B7-H3-expressing immune and tumor cells, thereby inducing selective toxicity in these cells. EGFR, overexpressed by a variety of cancer cell types, plays a key role in tumor cell proliferation, tumor angiogenesis and radio- and chemoresistance. B7-H3, a type I transmembrane protein and a member of the B7 co-stimulatory protein superfamily, is overexpressed on certain tumor cell types and on various immune cells. It is a negative regulator of T-cell activation and its overexpression plays a key role in tumor cell invasion and metastasis."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1182659", "l": "Hyalocyte", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5216201", "l": "Eosinophils|NCnc|Pt|CSF", "d": []}]}
{"type": "biolink:Cell", "ic": "92.728541327098611", "identifiers": [{"i": "CL:0002201", "l": "renal beta-intercalated cell", "d": ["A renal intercalated cell that secretes base and reabsorbs acid in the distal segments of the kidney tubule to maintain acid/base balance."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157229", "l": "CD1 blasts | Bone marrow | Cell markers", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4323915", "l": "Set of trunk neural crest cells", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2325623", "l": "Pyramidal cell of precentral gyrus of cerebral hemisphere", "d": []}, {"i": "SNOMEDCT:89416001", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0225467", "l": "Structure of middle cells of ethmoid sinus", "d": []}, {"i": "SNOMEDCT:57232001", "d": []}]}
{"type": "biolink:Cell", "ic": "49.940938118516591", "identifiers": [{"i": "UMLS:C1518293", "l": "Neuron, Neuroepithelial Cell, and Supporting Cell of the Nervous System", "d": []}, {"i": "NCIT:C41405", "l": "Neuron, Neuroepithelial Cell, and Supporting Cell of the Nervous System", "d": ["A grouping for all the different types of cells of the nervous system."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C3489668", "l": "Neoplastic Colony-Forming Units", "d": []}]}
{"type": "biolink:Cell", "ic": "49.858970917164136", "identifiers": [{"i": "UMLS:C1510779", "l": "Adenocarcinoma Cell", "d": []}, {"i": "NCIT:C36773", "l": "Adenocarcinoma Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1510684", "l": "ADA Transduced T Cell", "d": []}, {"i": "NCIT:C28797", "l": "ADA Transduced T Cell", "d": ["T cells harvested from a patient with adenosine deaminase (ADA) deficiency and transduced with a vector containing the gene for ADA. ADA catalyzes the hydrolysis of adenosine to inosine; ADA deficiency causes a form of severe combined immunodeficiency (SCID).  Following genetic modification, the T cells are returned to the patient, where they produce functional ADA.  ADA-transduced T cells have been shown to improve immune function in individuals with ADA deficiency. (NCI04)"]}]}
{"type": "biolink:Cell", "ic": "70.216808612803263", "identifiers": [{"i": "CL:0008034", "l": "mural cell", "d": ["Mural cells are pericytes and the vascular smooth muscle cells (vSMCs) of the microcirculation."]}]}
{"type": "biolink:Cell", "ic": "72.072061987060081", "identifiers": [{"i": "UMLS:C0682610", "l": "Enterocytes", "d": []}, {"i": "NCIT:C12585", "l": "Enterocyte", "d": ["A type of epithelial cell that lines the intestines and colon. It participates in the absorption of water and nutrients from the intestinal lumen, and in the secretion of digestive enzymes."]}, {"i": "MESH:D020895", "l": "Enterocytes", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C3275034", "l": "CNDO-109", "d": []}, {"i": "NCIT:C99898", "l": "CNDO-109-activated Allogeneic Natural Killer Cells", "d": ["A preparation of non-interleukin-2 primed, tumor activated allogeneic natural killer (NK) cells with potential immunostimulating activity. The allogeneic NK cells obtained from a first or second degree relative of the patient are co-incubated with a lysate from the CTV-1 cell line, a minimally differentiated myeloid line derived from an acute myelogenous leukemia patient. Infusion of CNDO-109-activated allogeneic NK cells may be able to lyse and destroy NK-resistant tumor cells and a broad spectrum of tumor cells."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1977405", "l": "Granulocytes.CD59", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2324343", "l": "Type 1 vestibular sensory cell of epithelium of crista of ampulla of semicircular duct of membranous labyrinth", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1440247", "l": "Cells.CD11c+CD20+", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1317190", "l": "Cells.CD2+CD7+", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0000143", "l": "guidepost cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5219171", "l": "Leukocytes|PrThr|Urine", "d": []}]}
{"type": "biolink:Cell", "ic": "92.728541327098611", "identifiers": [{"i": "CL:0000725", "l": "nitrogen fixing cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2328847", "l": "Set of cholinergic cells of globus pallidus [Ch2]", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0882865", "l": "Cells.CD4+HLA-DR+", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C4725102", "l": "Autologous CD123-4SCAR-expressing T-cells 4SCAR123", "d": []}, {"i": "NCIT:C148526", "l": "Autologous CD123-4SCAR-expressing T-cells 4SCAR123", "d": ["A preparation of genetically modified autologous T-cells transduced with a replication incompetent, self-inactivating lentiviral vector expressing a  fourth generation chimeric antigen receptor (4SCAR) consisting of an anti-CD123 (interleukin-3 receptor alpha chain or IL3RA) single chain variable fragment (scFv) that is coupled to the costimulatory signaling domains CD28, CD137, CD27 and the zeta chain of the T-cell receptor (TCR), and is fused with the suicide gene inducible caspase 9 (iCasp9), with potential immunostimulating and antineoplastic activities. Upon administration, autologous CD123-4SCAR-expressing T-cells 4SCAR123 are directed to and induce selective toxicity in CD123-expressing tumor cells. iCasp9 consists of a human FK506 drug-binding domain with an F36V mutation (FKBP12-F36V) linked to human caspase 9. If the administered T-cells lead to unacceptable side effects, the chemical homodimerizer AP1903 can be administered. AP1903 binds to the drug binding FKBP12-F36V domain and induces activation of caspase 9, which results in the apoptosis of the administered T-cells and enhances safety of this agent. CD123 is normally expressed on committed blood progenitor cells in the bone marrow; its overexpression is associated with increased leukemic cell proliferation and aggressiveness. CD28, CD137 and CD27, T-cell surface-associated co-stimulatory molecules, are required for full T-cell activation and enhance both proliferation of T-cells and antitumor activity."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5163728", "l": "Erythrocytes | Urine | Urinalysis", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5174657", "l": "Neutrophils/100 cells | Bone marrow | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "ic": "89.347505587204751", "identifiers": [{"i": "CL:0002553", "l": "fibroblast of lung", "d": ["A fibroblast that is part of lung."]}]}
{"type": "biolink:Cell", "ic": "73.976162571356099", "identifiers": [{"i": "CL:1000450", "l": "epithelial cell of glomerular capsule", "d": ["An epithelial cell that is part of the glomerular capsule."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2328087", "l": "Paravertebral ganglion neuron", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157553", "l": "CD4+CD45RO+ cells | Cerebral spinal fluid | Cell markers", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C2983776", "l": "Allogeneic IL13-Zetakine/HyTK-Expressing-Glucocorticoid Resistant Cytotoxic T Lymphocytes GRm13Z40-2", "d": []}, {"i": "NCIT:C90577", "l": "Allogeneic IL13-Zetakine/HyTK-Expressing-Glucocorticoid Resistant Cytotoxic T Lymphocytes GRm13Z40-2", "d": ["A preparation of glucocorticoid receptor (GR) negative, allogeneic cytotoxic T-lymphocytes (CTLs) expressing a membrane-tethered interleukin 13 (IL13) cytokine chimeric T-cell antigen receptor (zetakine), with potential antineoplastic activity. Upon transfection of donor T-lymphocytes with a plasmid encoding a fusion protein of the IL13-zetakine and the selection-suicide expression enzyme HyTK, these modified CTLs are expanded and introduced into a patient with glioblastoma multiforme (GBM). This agent specifically targets IL13 receptor alpha2, a glioma-restricted cell-surface epitope; the CTLs exert their cytolytic effect thereby killing IL13Ra2-expressing glioma cells. In addition, IL13-zetakine redirected CTLs induce production of certain cytokines. Furthermore, due to the fact that these CTLs are GR negative, they can be used concomitantly with glucocorticoid therapy. The IL13-zetakine consists of an extracellular IL-13 E13Y mutein-human IgG4 hinge-Fc chimera fused to human cytoplasmic CD3-zeta via the transmembrane domain of human CD4."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0000495", "l": "blue sensitive photoreceptor cell", "d": ["A photoreceptor cell that is sensitive to blue light."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C2346934", "l": "Malignant Fusiform Osteoblast", "d": []}, {"i": "NCIT:C67521", "l": "Malignant Fusiform Osteoblast", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5178162", "l": "Primary Spermatocytes | Semen | Fertility testing", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:1001577", "l": "tonsil squamous cell", "d": ["Squamous cell of tonsil epithelium."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5155308", "l": "Blister cells | Blood | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4696681", "l": "Cells.CD19+CD38+IgM-", "d": []}]}
{"type": "biolink:Cell", "ic": "87.120474278337809", "identifiers": [{"i": "CL:0002364", "l": "cortical thymic epithelial cell", "d": ["An epithelial cell of the cortical portion of the thymus. Epithelial cells in this region are required for positive selection of CD8-positive T cells."]}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "CL:0000994", "l": "immature CD11c-negative plasmacytoid dendritic cell", "d": ["Immature CD11c-negative plasmacytoid dendritic cell is a CD11c-negative plasmacytoid dendritic cell is CD80-negative, CD86-low and MHCII-low."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2360256", "l": "Anulocyte", "d": []}, {"i": "SNOMEDCT:724194007", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C3898995", "l": "HLA-DP0401/0402-Restricted MAGE-A3-Reactive T Cell Receptor-transduced Autologous T Cells", "d": []}, {"i": "NCIT:C115979", "l": "HLA-DP0401/0402-Restricted MAGE-A3-Reactive T Cell Receptor-transduced Autologous T Cells", "d": ["Human autologous T-lymphocytes transduced with a retroviral vector encoding a T-cell receptor (TCR) specific for the human leukocyte antigen (HLA)-DP0401/0402-restricted, melanoma antigen A3 (MAGE-A3), with potential antineoplastic activity. CD4-positive cells are isolated from a patient, transduced with an anti-MAGE-A3-DP0401/0402 restricted TCR, expanded ex vivo, and reintroduced into the HLA-DP0401/0402 positive patient. Then, the HLA-DP0401/0402-restricted, MAGE-A3-reactive TCR-transduced autologous T cells bind to tumor cells expressing the MAGE-A3 antigen, which may result in both an inhibition of growth and increased cell death for MAGE-A3-expressing cancer cells. The tumor-associated antigen MAGE-A3 is overexpressed by a variety of cancer cell types."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1440323", "l": "Cells.CD49c", "d": []}]}
{"type": "biolink:Cell", "ic": "74.107231545810777", "identifiers": [{"i": "CL:0002315", "l": "supporting cell of cochlea", "d": ["An epithelial supporting cell located in the cochlea."]}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "CL:0002220", "l": "interstitial cell of pineal gland", "d": ["A cell located between the pinealocytes."]}]}
{"type": "biolink:Cell", "ic": "58.188159350298456", "identifiers": [{"i": "UMLS:C0221910", "l": "Squamous Epithelial Cells", "d": []}, {"i": "NCIT:C12849", "l": "Squamous Cell", "d": []}, {"i": "SNOMEDCT:80554009", "d": []}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "CL:0002367", "l": "trabecular meshwork cell", "d": ["A cell that lines the trabecular meshwork, which is an area of tissue in the eye located around the base of the cornea, near the ciliary body, and is responsible for draining the aqueous humor from the eye via the anterior chamber (the chamber on the front of the eye covered by the cornea). This cell may play a role in regulating intraocular pressure."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1182621", "l": "Epithelial cell of wall of inferior part of anal canal", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1267926", "l": "Lymphocyte positive for CD44 antigen", "d": []}, {"i": "SNOMEDCT:117370000", "d": []}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "CL:2000038", "l": "posterior lateral line neuromast mantle cell", "d": ["Any neuromast mantle cell that is part of a posterior lateral line."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4551909", "l": "Bone Marrow Stromal Stem Cells", "d": []}, {"i": "SNOMEDCT:418460001", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5171653", "l": "Lymphocyte T-cell and B-cell and Natural killer subsets | Blood | Cell markers", "d": []}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "UMLS:C0037866", "l": "Spermatogonia", "d": []}, {"i": "NCIT:C12606", "l": "Spermatogonium", "d": ["An undeveloped male germ cell. Spermatogonia develop into primary spermatocytes."]}, {"i": "MESH:D013093", "l": "Spermatogonia", "d": []}, {"i": "SNOMEDCT:67807008", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1519737", "l": "Tzanck Cell", "d": []}, {"i": "NCIT:C39665", "l": "Tzanck Cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1267945", "l": "Lymphocyte positive for CD53 antigen", "d": []}, {"i": "SNOMEDCT:117388008", "d": []}]}
{"type": "biolink:Cell", "ic": "80.511444690059548", "identifiers": [{"i": "UMLS:C1882043", "l": "Neoplastic Apocrine Cell", "d": []}, {"i": "NCIT:C62494", "l": "Neoplastic Apocrine Cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4304491", "l": "Population of all polymorphonuclear cells in portion of fluid", "d": []}, {"i": "SNOMEDCT:719697003", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157228", "l": "CD1 blasts | Blood | Cell markers", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5181480", "l": "Spherocytes.micro | Blood | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "ic": "77.944915021140389", "identifiers": [{"i": "UMLS:C1708863", "l": "Malignant Cell with Large Nucleus and Abundant Eosinophilic Cytoplasm", "d": []}, {"i": "NCIT:C53666", "l": "Malignant Cell with Large Nucleus and Abundant Eosinophilic Cytoplasm", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5170899", "l": "Leukemia markers | Blood | Cell markers", "d": []}]}
{"type": "biolink:Cell", "ic": "92.728541327098611", "identifiers": [{"i": "CL:0000423", "l": "tip cell", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002446", "l": "Ly49CI-negative natural killer cell, mouse", "d": ["A NK1.1-positive T cell that is Ly49Cl-negative."]}]}
{"type": "biolink:Cell", "ic": "65.099244958558103", "identifiers": [{"i": "CL:0000235", "l": "macrophage", "d": ["A mononuclear phagocyte present in variety of tissues, typically differentiated from monocytes, capable of phagocytosing a variety of extracellular particulate material, including immune complexes, microorganisms, and dead cells."]}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "CL:0000847", "l": "ciliated olfactory receptor neuron", "d": ["An olfactory receptor cell in which the apical ending of the dendrite is a pronounced ciliated olfactory knob."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2330671", "l": "Goblet cell of epithelium of large intestine", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1267801", "l": "CYIG MU+ lymphocyte", "d": []}, {"i": "SNOMEDCT:117505005", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0000041", "l": "mature eosinophil", "d": ["A fully differentiated eosinophil, a granular leukocyte with a nucleus that usually has two lobes connected by one or more slender threads, and cytoplasm containing coarse, round granules that are uniform in size and which can be stained by the dye eosin. Cells are also differentiated from other granulocytes by a small nuclear-to-cytoplasm ratio (1:3). This cell type is CD49d-positive."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157521", "l": "CD3-CD16+CD56+ (Natural killer) cells | Tissue and Smears | Cell markers", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0682613", "l": "hepatocyte structure", "d": []}]}
{"type": "biolink:Cell", "ic": "81.247621244257502", "identifiers": [{"i": "UMLS:C1706984", "l": "Bone Marrow Stem Cell Committed to the Megakaryocytic Lineage", "d": []}, {"i": "NCIT:C43221", "l": "Bone Marrow Stem Cell Committed to the Megakaryocytic Lineage", "d": ["A primitive undifferentiated cell which can undergo division and can give rise to one of the early megakaryocytes."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2697995", "l": "MultiStem", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5216203", "l": "Eosinophils|NCnc|Pt|Periton fld", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1978802", "l": "Cytokeratin cells", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4300400", "l": "Cells.chromosome region 7q31 deletion", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2338315", "l": "Epithelial cell of large intestine", "d": []}]}
{"type": "biolink:Cell", "ic": "78.695011174409487", "identifiers": [{"i": "CL:0000937", "l": "pre-natural killer cell", "d": ["Cell committed to natural killer cell lineage that has the phenotype CD122-positive, CD34-positive, and CD117-positive. This cell type lacks expression of natural killer receptor proteins."]}]}
{"type": "biolink:Cell", "ic": "84.128890093485552", "identifiers": [{"i": "NCIT:C12598", "l": "Oocyte", "d": ["The female gamete, germ cells in stages between the prophase of the first maturation division and the completion of the second maturation division."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0229536", "l": "Acidophil cell of pars distalis of adenohypophysis", "d": []}, {"i": "SNOMEDCT:54913007", "d": []}]}
{"type": "biolink:Cell", "ic": "56.508857221095191", "identifiers": [{"i": "UMLS:C3641722", "l": "Effector T-Lymphocyte", "d": []}, {"i": "NCIT:C104083", "l": "Effector T-Lymphocyte", "d": ["A mature T-lymphocyte that has differentiated into a form that can mount an antigen-specific immune response."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4733226", "l": "CAR.CD30-expressing autologous Epstein-Barr virus-specific cytotoxic T-lymphocytes", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C4723730", "l": "Anti-K-RAS G12D mTCR-transduced Autologous Peripheral Blood Lymphocytes", "d": []}, {"i": "NCIT:C156889", "l": "Anti-K-RAS G12D mTCR-transduced Autologous Peripheral Blood Lymphocytes", "d": ["Autologous peripheral blood lymphocytes (PBLs) transduced with a retroviral vector encoding for an HLA class I histocompatibility antigen A*11:01 (HLA-A1101)-restricted murine T-cell receptor (mTCR) that recognizes the glycine (Gly, G) to aspartic acid (Asp, D) point mutation at position 12 (G12D) variant of K-RAS (KRAS), with potential immunomodulating and antineoplastic activities. HLA-A1101-positive PBLs are harvested from a K-RAS G12D-expressing cancer patient and transfected with a retroviral vector that encodes anti-K-RAS G12D mTCR. The transduced PBLs are then expanded in culture. When reintroduced to the patient, these anti-K-RAS G12D mTCR-expressing PBLs target and bind to K-RAS G12D-overexpressing tumor cells, which results in both cytokine secretion, including interferon-gamma (IFN-g), and tumor cell lysis. K-RAS, a member of the RAS family of oncogenes, serves an important role in cell signaling, division and differentiation. Mutation of K-RAS may induce constitutive signal transduction leading to tumor cell growth, proliferation, invasion, and metastasis."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C4288626", "l": "NK Cell-enriched Donor Lymphocytes", "d": []}, {"i": "NCIT:C127939", "l": "NK Cell-enriched Donor Lymphocytes", "d": ["A preparation of donor-derived lymphocytes that are enriched for donor-derived natural killer (NK) cells, with direct tumor cytotoxic activity. Following allogeneic stem cell transplantation and subsequent infusion of the NK cell-enriched donor lymphocytes, these cells recognize and bind to tumor cells, upon which they secrete and release perforins, granzymes, and cytokines, which results in cancer cell lysis. Infusion of donor lymphocytes is limited by the risk of graft-versus-host disease (GVHD) and NK cells normally constitute only a small portion of circulating lymphocytes. Therefore, NK cell-enrichment may result in higher amounts of NK cells per infusion and improved anti-tumor immunity without increasing the risk of GVHD."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C3272725", "l": "Mini-Gemistocyte", "d": []}, {"i": "NCIT:C96345", "l": "Mini-Gemistocyte", "d": ["A neoplastic gemistocytic astrocyte characterized by a diminutive size, a single, eccentric nucleus, and a cytoplasmic droplet of eosinophilic material."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0333856", "l": "Non-cleaved cell", "d": []}, {"i": "SNOMEDCT:63584005", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C3831562", "l": "Allogeneic Glioblastoma Stem-like Cell Line Lysate-pulsed Autologous Dendritic Cell Vaccine", "d": []}, {"i": "NCIT:C113296", "l": "Allogeneic Glioblastoma Stem-like Cell Line Lysate-pulsed Autologous Dendritic Cell Vaccine", "d": ["A cell-based cancer vaccine composed of autologous dendritic cells (DCs) pulsed with lysates from an allogeneic glioblastoma (GBM) stem-like cell line, with potential immunostimulatory and antineoplastic activities. Upon administration allogeneic glioblastoma stem-like cell line lysate-pulsed autologous dendritic cell vaccine exposes the immune system to GBM stem cell antigens, which may result in cytotoxic T lymphocyte (CTL) and antibody responses against GBM cells. This leads to GBM cell lysis. GBM stem-like cells contain a specific range of antigens that are essential for the neoplastic growth and survival of GBM cells."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002150", "l": "epithelioid macrophage", "d": ["Epithelioid macrophage is an activated macrophage that resembles an epithelial cell with finely granular, pale eosinophilic cytoplasm and central, ovoid nucleus (oval or elongate). This cell type is able to merge into one another to form aggregates. The presence of such aggregates may characterize some pathologic conditions, mainly granulomatous inflammation."]}]}
{"type": "biolink:Cell", "ic": "92.728541327098611", "identifiers": [{"i": "CL:0000941", "l": "thymic conventional dendritic cell", "d": ["A dendritic cell arising in thymus that has the phenotype CD11c-positive, CD11b-negative, and CD45RA-negative."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5174097", "l": "Myelocytes | Body fluid | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C4725791", "l": "Allogeneic T-lymphocytes Expressing NY-ESO-1-C259-specific TCR", "d": []}, {"i": "NCIT:C150511", "l": "Allogeneic T-lymphocytes Expressing NY-ESO-1-C259-specific TCR", "d": ["Genetically engineered human allogeneic T-lymphocytes that are transduced with a retroviral vector encoding a T-cell receptor (TCR) specific for the cancer/testis antigen NY-ESO-1, with potential antineoplastic activity. Upon isolation, transduction, expansion ex vivo and introduction into the patient, the allogeneic T-lymphocytes expressing NY-ESO-1-C259-specific TCR specifically target and bind to NY-ESO-1-overexpressing tumor cells. This may result in the specific cytotoxic T-lymphocyte (CTL) killing of NY-ESO-1-positive cancer cells. NY-ESO-1, a tumor-associated antigen (TAA), is expressed in normal testis and on the surface of various tumor cell types."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2329214", "l": "Neurogliaform cell of cerebral cortex", "d": []}]}
{"type": "biolink:Cell", "ic": "76.46797986554256", "identifiers": [{"i": "CL:0000558", "l": "reticulocyte", "d": ["An immature erythrocyte that changes the protein composition of its plasma membrane by exosome formation and extrusion. The types of protein removed differ between species though removal of the transferrin receptor is apparent in mammals and birds."]}]}
{"type": "biolink:Cell", "ic": "75.26123597683771", "identifiers": [{"i": "UMLS:C1708916", "l": "Malignant Spindle Endothelial Cell", "d": []}, {"i": "NCIT:C53405", "l": "Malignant Spindle Endothelial Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1518067", "l": "Lymphocyte with Basophilic Villous Cytoplasm", "d": []}, {"i": "NCIT:C36993", "l": "Lymphocyte with Basophilic Villous Cytoplasm", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1440421", "l": "Cells.TCR alpha beta", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5185785", "l": "ZAP70 cells | Blood | Cell markers", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1440259", "l": "Cells.CD16+CD57+", "d": []}]}
{"type": "biolink:Cell", "ic": "88.140761698499901", "identifiers": [{"i": "CL:0019032", "l": "intestinal tuft cell", "d": ["Any brush cell that is part of the intestinal epithelium."]}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "CL:0002376", "l": "non-myelinating Schwann cell", "d": ["A glial cell that ensheaths multiple small diameter axons in the peripheral nervous system. The non-myelinating Schwann cell is embedded among neurons (axons) with minimal extracellular spaces separating them from nerve cell membranes and has a basal lamina. Cells can survive without an axon present. These cells can de-differentiate into immature Schwann cells."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5381000", "l": "Cells.CD8.HLA-B8 CMV specific", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1181740", "l": "Type III cell of adrenal cortex", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2330614", "l": "Transitional myocyte of atrial part of atrioventricular bundle", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1268444", "l": "Nonhematic cell", "d": []}, {"i": "SNOMEDCT:115611000", "d": []}]}
{"type": "biolink:Cell", "ic": "76.281523396999802", "identifiers": [{"i": "CL:0000824", "l": "mature natural killer cell", "d": ["A natural killer cell that is developmentally mature and expresses a variety of inhibitory and activating receptors that recognize MHC class I and other stress related molecules."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5173467", "l": "Monocytes+Macrophages | Body fluid | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "ic": "87.120474278337809", "identifiers": [{"i": "CL:0002003", "l": "CD34-positive, GlyA-negative erythroid progenitor cell", "d": ["An erythroid progenitor cell that is CD34-positive and is GlyA-negative."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1267817", "l": "Lymphocyte positive for both CD3 antigen and CD16 antigen", "d": []}, {"i": "SNOMEDCT:117519005", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1512049", "l": "Downey Cell", "d": []}, {"i": "NCIT:C36736", "l": "Downey Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "73.239986017158159", "identifiers": [{"i": "UMLS:C1513756", "l": "Mummified Cell", "d": []}, {"i": "NCIT:C37025", "l": "Mummified Cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2337445", "l": "Type EC2 enteroendocrine cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157405", "l": "CD235a cells | Blood | Cell markers", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:1000382", "l": "type 2 vestibular sensory cell of stato-acoustic epithelium", "d": ["A type II vestibular sensory cell that is part of the stato-acoustic epithelium."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0009113", "l": "T follicular regulatory cell", "d": ["A regulatory T cell present in the B cell follicles and germinal centers of lymphoid tissues. In humans, it is CXCR5+."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5186954", "l": "Promyelocytes | Fetus | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "ic": "73.721563224321088", "identifiers": [{"i": "CL:0000787", "l": "memory B cell", "d": ["A memory B cell is a mature B cell that is long-lived, readily activated upon re-encounter of its antigenic determinant, and has been selected for expression of higher affinity immunoglobulin. This cell type has the phenotype CD19-positive, CD20-positive, MHC Class II-positive, and CD138-negative."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C2984196", "l": "Therapeutic Allogeneic Cytotoxic T-Lymphocytes", "d": []}, {"i": "NCIT:C91374", "l": "Therapeutic Allogeneic Cytotoxic T-Lymphocytes", "d": ["A population of cytotoxic T-lymphocytes (CTLs) that are therapeutically administered to a recipient individual who is genetically distinct from a donor of the same species."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2328623", "l": "Fibrocyte of adventitia of ureter", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:2000062", "l": "placental villus capillary endothelial cell", "d": ["Any capillary endothelial cell that is part of a placenta."]}]}
{"type": "biolink:Cell", "ic": "82.532694649739099", "identifiers": [{"i": "UMLS:C1518212", "l": "Malignant Myoepithelial Cell", "d": []}, {"i": "NCIT:C36780", "l": "Malignant Myoepithelial Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C2986403", "l": "Anti-CTLA4 MoAb RNA/GITRL RNA-transfected Autologous Dendritic Cell Vaccine", "d": []}, {"i": "NCIT:C94218", "l": "Anti-CTLA4 MoAb RNA/GITRL RNA-transfected Autologous Dendritic Cell Vaccine", "d": ["An autologous dendritic cell (DC) cancer vaccine with potential immunostimulatory activity. Anti-CTLA4 MoAb RNA/GITRL RNA-transfected DC vaccine is prepared by transfecting DCs with RNAs encoding humanized heavy and light chains of the anti-CTLA4 (cytotoxic T-Lymphocyte-Associated Antigen 4) monoclonal antibody and tumor necrosis factor (ligand) superfamily, member 18 (TNFSF18 or GlTRL); expression of anti-CTLA4 blocks the inhibitory effect of CTLA4 on the activation of T-lymphocytes, while expression of GlTRL modulates T lymphocyte survival in peripheral tissues. Co-vaccination of this vaccine with melanoma antigen specific vaccine may eliminate the adverse effects associated with systemic administration of immune modulators, while also enhancing vaccine-induced immune responses."]}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "CL:1000022", "l": "mesonephric nephron tubule epithelial cell", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:1001568", "l": "pulmonary artery endothelial cell", "d": []}]}
{"type": "biolink:Cell", "ic": "55.568507571130205", "identifiers": [{"i": "CL:0002372", "l": "myotube", "d": ["A transversely striated, synctial muscle cell, formed by the fusion of myoblasts."]}]}
{"type": "biolink:Cell", "ic": "90.82444074280258", "identifiers": [{"i": "CL:0000778", "l": "mononuclear osteoclast", "d": ["A specialized mononuclear osteoclast associated with the absorption and removal of bone, precursor of multinuclear osteoclasts."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C4733604", "l": "Genetically-modified Anti-HER2-CAR-CD28zeta-expressing Allogeneic NK-92/5.28.z Cells", "d": []}, {"i": "NCIT:C154568", "l": "Genetically-modified Anti-HER2-CAR-CD28zeta-expressing Allogeneic NK-92/5.28.z Cells", "d": ["A preparation of genetically-modified natural killer (NK) cells derived from the allogeneic NK-92 cell line that are transduced with a lentiviral vector expressing a codon-optimized chimeric antigen receptor (CAR) consisting of a single chain variable fragment (scFv) of the anti-human epidermal growth factor 2 (HER2; ErbB2) monoclonal antibody FRP5, and fused, via hinge and transmembrane regions, to the intracellular domain of the costimulatory molecule CD28, and the intracellular signaling domain of the T-cell antigen receptor complex zeta chain (CD3-zeta), with potential cytolytic, immunomodulating and antineoplastic activities. Upon infusion of the genetically modified anti-HER2-CAR-CD28zeta-expressing allogeneic NK-92/5.28.z cells, the NK cells recognize and bind to HER2 expressed on tumor cells. This leads to the secretion and release of perforins, granzymes, cytokines and chemokines, which results in selective tumor cell lysis in HER2-expressing tumor cells. HER2, a receptor tyrosine kinase (RTK) mutated or overexpressed in many tumor cell types, plays a significant role in tumor cell proliferation and tumor vascularization. The NK-92 cells are derived from a human cytotoxic cell line composed of allogeneic, activated, interleukin-2-(IL-2) dependent-NK cells from a 50-year old male patient with rapidly progressive non-Hodgkin's lymphoma. As NK-92 cells are devoid of killer inhibitory receptors (KIRs; also called killer cell immunoglobulin-like receptors), which are negative regulators of NK cell activity, cancer cells are unable to suppress the cancer cell killing ability of the NK-92 cells."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:4006001", "l": "fibroblast of skin of scalp", "d": ["A fibroblast that is part of the skin of scalp."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4510921", "l": "Blast cell positive for CD19 antigen", "d": []}, {"i": "SNOMEDCT:725177004", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157352", "l": "CD19+CD27+ cells | Blood | Cell markers", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002026", "l": "CD34-negative, CD41-positive, CD42-positive megakaryocyte cell", "d": ["A megakaryocyte progenitor cell that is CD34-negative, CD41-positive and CD42-positive."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0772149", "l": "red blood cells,dehydrated", "d": []}]}
{"type": "biolink:Cell", "ic": "87.120474278337809", "identifiers": [{"i": "CL:1001571", "l": "hippocampal pyramidal neuron", "d": ["A pyramidal neuron with a soma found in the hippocampus."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:4033020", "l": "mucus secreting cell of trachea gland", "d": ["A mucus secreting cell that is part of a submucosal gland of the trachea."]}]}
{"type": "biolink:Cell", "ic": "80.869303025598512", "identifiers": [{"i": "CL:0002039", "l": "immature NK T cell stage I", "d": ["A CD24-high, CD4-low, CD8-low, CD44-negative, NK1.1-negative NK T cell."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1267865", "l": "Lymphocyte positive for both CD11 antigen and CD20 antigen", "d": []}, {"i": "SNOMEDCT:117546000", "d": []}]}
{"type": "biolink:Cell", "ic": "89.347505587204751", "identifiers": [{"i": "UMLS:C1513930", "l": "Neoplastic B-Prolymphocyte", "d": []}, {"i": "NCIT:C37183", "l": "Neoplastic B-Prolymphocyte", "d": []}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "UMLS:C1708868", "l": "Malignant Corticotroph Cell", "d": []}, {"i": "NCIT:C45944", "l": "Malignant Corticotroph Cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5174624", "l": "Neutrophils | Stool | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "CL:0000032", "l": "neuroplacodal cell", "d": ["A cell of a platelike structure, especially a thickened plate of ectoderm in the early embryo, from which a sense organ develops."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5170924", "l": "Leukocytes | Cerebral spinal fluid | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157527", "l": "CD3-CD57+ cells | Body fluid | Cell markers", "d": []}]}
{"type": "biolink:Cell", "ic": "84.75972595860604", "identifiers": [{"i": "CL:1000617", "l": "kidney inner medulla cell", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1520211", "l": "Yolk Cell", "d": []}, {"i": "NCIT:C33933", "l": "Yolk Cell", "d": ["A cell that splits off from the inner cell mass of the blastocyst and becomes part of the primitive yolk sac, which in non-mammals nourishes the embryo during development."]}]}
{"type": "biolink:Cell", "ic": "57.069613539660139", "identifiers": [{"i": "CL:0000499", "l": "stromal cell", "d": ["A connective tissue cell of an organ found in the loose connective tissue. These are most often associated with the uterine mucosa and the ovary as well as the hematopoietic system and elsewhere."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0004229", "l": "A2-like amacrine cell", "d": ["A bistratified amacrine cell with a small dendritic field that has dendrite stratification in S2, and in S3 and S4."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1182791", "l": "Glomerular endothelial cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C3494245", "l": "Sf9 Cells", "d": []}, {"i": "MESH:D061987", "l": "Sf9 Cells", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002500", "l": "P enteroendocrine cell", "d": ["A P/D1 enteroendocrine cell that is Grimelius positive and stores bombesin-like polypeptide."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1440224", "l": "CD43.T-Cell monocyte+Myeloid cell", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002317", "l": "external limiting cell of vestibular epithelium", "d": ["An external limiting cell found in the vestibular epithelium."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5703599", "l": "LentiGlobin BB305", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002300", "l": "type-7 epithelial cell of thymus", "d": ["A small medullary thymic epithelial cell with a spindle shape, often arranged in groups and connected to each other by large desmosomes and interdigitations. The cytoplasm is sparse, with scanty organelles and thick bundles of cytokeratin."]}]}
{"type": "biolink:Cell", "ic": "84.75972595860604", "identifiers": [{"i": "CL:0002393", "l": "intermediate monocyte", "d": ["A monocyte that has characteristics of both patrolling and inflammatory monocytes."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:1000348", "l": "basal cell of epithelium of trachea", "d": ["A basal cell that is part of the epithelium of trachea."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2338609", "l": "Type P enteroendocrine cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5454454", "l": "Epithelial cells | Cervix or Vagina | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4722589", "l": "KTE-C19", "d": []}]}
{"type": "biolink:Cell", "ic": "86.236661114203869", "identifiers": [{"i": "CL:0000198", "l": "pain receptor cell", "d": ["The peripheral receptor for pain. Includes receptors which are sensitive to painful mechanical stimuli, extreme heat or cold, and chemical stimuli. All mammalian nociceptors are free nerve endings."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2964437", "l": "Pseudo Pelger Huet cells", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4322732", "l": "CD33+ hemal cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0947305", "l": "Erythrocytes.CD59", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0005021", "l": "mesenchymal lymphangioblast", "d": ["Mesenchymal derived lymphatic progenitor cells that give rise to the superficial lymphatics."]}]}
{"type": "biolink:Cell", "ic": "48.052320036996946", "identifiers": [{"i": "CL:0002320", "l": "connective tissue cell", "d": ["A cell of the supporting or framework tissue of the body, arising chiefly from the embryonic mesoderm and including adipose tissue, cartilage, and bone."]}]}
{"type": "biolink:Cell", "ic": "92.728541327098611", "identifiers": [{"i": "UMLS:C1514275", "l": "Postradiation Dysplastic Epithelial Cell", "d": []}, {"i": "NCIT:C36804", "l": "Postradiation Dysplastic Epithelial Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1515148", "l": "TE06", "d": []}, {"i": "NCIT:C20300", "l": "TE06", "d": ["Provider: Technion University, Haifa, Israel. No information from provider. This cell line meets the criteria for the use of human embryonic stem cells by federally funded researchers."]}]}
{"type": "biolink:Cell", "ic": "87.120474278337809", "identifiers": [{"i": "CL:0000833", "l": "eosinophilic promyelocyte", "d": ["A promyelocyte committed to the eosinophil lineage."]}]}
{"type": "biolink:Cell", "ic": "54.823870905958884", "identifiers": [{"i": "UMLS:C1514110", "l": "Neoplastic T-Lymphocyte and Neoplastic Natural Killer Cell", "d": []}, {"i": "NCIT:C39566", "l": "Neoplastic T-Lymphocyte and Neoplastic Natural Killer Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "89.347505587204751", "identifiers": [{"i": "UMLS:C1522406", "l": "interstitial cell", "d": []}, {"i": "NCIT:C32870", "l": "Interstitial Cell", "d": ["An interstitial cell is a cell that is part of the connective and soft tissues."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:4023093", "l": "stellate pyramidal neuron", "d": ["A pyramidal neuron which lacks a tuft formation but extends small radial distances forming a star-like shape."]}]}
{"type": "biolink:Cell", "ic": "86.236661114203869", "identifiers": [{"i": "CL:0000693", "l": "neurogliaform cell", "d": ["An interneuron that has spider-like appearance with a small round soma, a large number (7-10) of short, smooth, or slightly beaded primary dendrites that give rise to only a few secondary branches, and a branched axon that establishes a dense axonal mesh with thin shafts."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:4033031", "l": "diffuse bipolar 4 cell", "d": ["An ON diffuse bipolar cell that predominantly connects to ON parasol cells and lateral amacrine cells."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C3282679", "l": "foreskin keratinocyte, neonatal", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5181331", "l": "Spermatids | Semen | Fertility testing", "d": []}]}
{"type": "biolink:Cell", "ic": "84.128890093485552", "identifiers": [{"i": "CL:4029001", "l": "gamete-nursing cell", "d": ["A cell that supports the development of a gamete by providing it cytoplasmic material (including entire organelles) by direct cross-membrane channels (del Pino, 2021)."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1631611", "l": "Bone marrow derived somatic stem cell", "d": []}, {"i": "SNOMEDCT:420190000", "d": []}]}
{"type": "biolink:Cell", "ic": "90.82444074280258", "identifiers": [{"i": "CL:1000427", "l": "adrenal cortex chromaffin cell", "d": ["A chromaffin cell that is part of the adrenal cortex."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157390", "l": "CD21 cells | Blood | Cell markers", "d": []}]}
{"type": "biolink:Cell", "ic": "89.347505587204751", "identifiers": [{"i": "CL:2000086", "l": "neocortex basket cell", "d": ["Any basket cell that is part of a neocortex."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5175151", "l": "Nucleated cells | Pericardial fluid | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4316924", "l": "Cell positive for CD8 antigen", "d": []}, {"i": "SNOMEDCT:732271007", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5178300", "l": "Promonocytes | Blood | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C4764367", "l": "iPSC-derived Natural Killer Cells FT500", "d": []}, {"i": "NCIT:C158438", "l": "iPSC-derived Natural Killer Cells FT500", "d": ["A preparation of off-the-shelf, natural killer (NK) cells derived from a clonal master induced pluripotent stem cell (iPSC) line, with potential antineoplastic and immunostimulatory activities. Upon administration, iPSC-derived natural killer cells FT500 bind to stress-induced ligands on tumor cells, leading to tumor cell lysis and release of tumor neoantigens. Additionally, iPSC-NK cells secrete inflammatory cytokines and chemokines including interferon-gamma (IFN-gamma), tumor necrosis factor-alpha (TNF-alpha), C-C motif chemokines 3, 4, and 22 (CCL3, CCL4, and CCL22), and C-X-C motif chemokine 10 (CXCL10), thereby enhancing T-cell activity and recruitment to the tumor site."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5174099", "l": "Myelocytes | Fetus | Blood | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5167747", "l": "HLA-B27 cells | Blood | Cell markers", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5690235", "l": "Burr cells | Body fluid | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "ic": "86.236661114203869", "identifiers": [{"i": "CL:0002070", "l": "type I vestibular sensory cell", "d": ["Bottle-shaped with narrow neck; broad, rounded basal portion where nucleus is located; stereocilia and a single kinocilium is present apically; receive nerve bouton at their base from an afferent cup-shaped (chalice or calyx) nerve ending."]}]}
{"type": "biolink:Cell", "ic": "72.79108406015925", "identifiers": [{"i": "UMLS:C1514271", "l": "Postgerminal Center B-Lymphocyte", "d": []}, {"i": "NCIT:C38340", "l": "Postgerminal Center B-Lymphocyte", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C4727557", "l": "Allogeneic CD19CAR-transfected Cytokine-induced Killer Cells", "d": []}, {"i": "NCIT:C154284", "l": "Allogeneic CD19CAR-transfected Cytokine-induced Killer Cells", "d": ["A preparation of allogeneic cytokine-induced killer (CIK) cells derived from peripheral blood mononuclear cells (PBMCs) transfected with the Sleeping Beauty (SB) transposon, CD19CAR (CARCIK-CD19), with potential immunomodulatory and antineoplastic activities. CIK cells are CD3- and CD56-positive, non-major histocompatibility complex (MHC)-restricted, natural killer (NK)-like T-lymphocytes. Upon infusion following an allogeneic stem cell transplantation, the CARCIK-CD19 cells bind to CD19-expressing tumor cells, thereby inducing selective toxicity in CD19-expressing tumor cells. CIK cells may have enhanced cytotoxic activity compared to lymphokine-activated killer (LAK) cells. CD19 is a B-cell specific cell surface antigen expressed in all B-cell lineage malignancies."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5170944", "l": "Leukocytes | Urine sediment | Urinalysis", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0000536", "l": "secondary motor neuron (sensu Teleostei)", "d": ["A secondary neuron (sensu Teleostei) that has a motor function."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1317191", "l": "Cells.CD227", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1517304", "l": "Foveolar cell", "d": []}, {"i": "NCIT:C32632", "l": "Foveolar Cell", "d": ["An epithelial cell found in the glands of the gastric mucosa."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5216219", "l": "Erythrocytes|NCnc|Pt|Synv fld", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1514295", "l": "Pre-Thymocyte", "d": []}, {"i": "NCIT:C33399", "l": "Pre-Thymocyte", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:1000703", "l": "kidney pelvis urothelial cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0229213", "l": "Rod cell of inner nuclear layer", "d": []}, {"i": "SNOMEDCT:34407003", "d": []}]}
{"type": "biolink:Cell", "ic": "90.82444074280258", "identifiers": [{"i": "UMLS:C1709202", "l": "Neoplastic Spindle-Shaped Chondrocyte", "d": []}, {"i": "NCIT:C53473", "l": "Neoplastic Spindle-Shaped Chondrocyte", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C4086237", "l": "Dendritic Cell-Precision Multiple Antigen T-Lymphocytes", "d": []}, {"i": "NCIT:C125634", "l": "Dendritic Cell-Precision Multiple Antigen T-Lymphocytes", "d": ["A preparation of dendritic cell-precision multiple antigen T-cells (DC-PMAT) that have been induced to specifically target multiple undisclosed tumor-associated antigens (TAAs), with potential antitumor activity. Although the exact mechanism(s) of action through which DC-PMAT cells exert their effects has yet to be elucidated, upon infusion, these cells may stimulate the host immune system to mount a highly-specific cytotoxic T-lymphocyte (CTL) response against tumors expressing common TAAs, which leads to tumor cell lysis."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1563925", "l": "Tr1 Cells", "d": []}]}
{"type": "biolink:Cell", "ic": "72.900487657105927", "identifiers": [{"i": "UMLS:C1513949", "l": "Neoplastic Ductal Epithelial Cell", "d": []}, {"i": "NCIT:C36877", "l": "Neoplastic Ductal Epithelial Cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1267847", "l": "Lymphocyte positive for both CD5 antigen and CD20 antigen", "d": []}, {"i": "SNOMEDCT:117534004", "d": []}]}
{"type": "biolink:Cell", "ic": "58.06975249093302", "identifiers": [{"i": "UMLS:C1517806", "l": "Leukemic Cell", "d": []}, {"i": "NCIT:C25553", "l": "Leukemic Cell", "d": ["Malignant hematopoietic cell originating in the clonal proliferation of myeloid or lymphoid precursor that undergoes an aberrant and poorly regulated process of organogenesis resulted in arrested maturation and cell capacity for unlimited self-renewal."]}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "UMLS:C1708924", "l": "Malignant Transitional Cell with Large Nucleus and Small Nucleolus", "d": []}, {"i": "NCIT:C54554", "l": "Malignant Transitional Cell with Large Nucleus and Small Nucleolus", "d": []}]}
{"type": "biolink:Cell", "ic": "75.751739371353352", "identifiers": [{"i": "CL:0000146", "l": "simple columnar epithelial cell", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1955939", "l": "Lymphoid Progenitor Cells", "d": []}, {"i": "NCIT:C13012", "l": "Lymphoid Progenitor Cell", "d": ["A hematopoietic stem cell that is committed to differentiate into T-, B- and natural killer (NK) cells."]}, {"i": "MESH:D054503", "l": "Lymphoid Progenitor Cells", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1267963", "l": "Lymphocyte positive for CD68 antigen", "d": []}, {"i": "SNOMEDCT:117404007", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0887811", "l": "Radiation Hybrids", "d": []}]}
{"type": "biolink:Cell", "ic": "63.195144374262064", "identifiers": [{"i": "UMLS:C1512642", "l": "Immature T-Lymphocyte", "d": []}, {"i": "NCIT:C38325", "l": "Immature T-Lymphocyte", "d": ["A cell developed in the thymus that differentiates into a mature T-lymphocyte. The maturation is dependent on several transcription factors including GATA-3 and c-Myb. The expression of the pre-T cell receptor alpha (pTa) gene occurs exclusively in the immature T lymphocyte."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C2985405", "l": "Nonspecific Immune Cell", "d": []}, {"i": "NCIT:C93035", "l": "Nonspecific Immune Cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1276862", "l": "Entire endocervical glandular cell", "d": []}, {"i": "SNOMEDCT:255065002", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:1000850", "l": "macula densa epithelial cell", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5417841", "l": "Autologous CD19-targeted CAR-T Cells GC007F", "d": []}, {"i": "NCIT:C171092", "l": "Autologous CD19-targeted CAR-T Cells GC007F", "d": ["A preparation of autologous T-lymphocytes that have been genetically modified to express a chimeric antigen receptor (CAR) consisting of a single chain variable fragment (scFv) of anti-CD19 coupled to as of yet not fully elucidated co-stimulatory molecules, with potential immunostimulating and antineoplastic activities. Upon transfusion, autologous CD19-targeted CAR-T cells GC007F target and bind to CD19-expressing neoplastic B-cells. This results in a cytotoxic T-lymphocyte (CTL) response against CD19-expressing tumor cells, the release of cytotoxic molecules and the induction of tumor cell lysis. CD19, cluster of differentiation 19, is a B-cell-specific cell surface antigen overexpressed in B-cell lineage tumors. The processing platform used, FasT (F) CAR-T, shortens the manufacturing time to produce the CAR-T cells within 24 hours."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1515153", "l": "TE72", "d": []}, {"i": "NCIT:C20303", "l": "TE72", "d": ["Provider: Technion University, Haifa, Israel. No information from provider. This cell line meets the criteria for the use of human embryonic stem cells by federally funded researchers."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1265917", "l": "Hand-Schüller-Christian histiocyte", "d": []}, {"i": "SNOMEDCT:123635008", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5561413", "l": "Stratagraft", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5555853", "l": "Autologous IL-12/Multi-targeted Primed T-cells RPTR 168", "d": []}, {"i": "NCIT:C179663", "l": "Autologous IL-12/Multi-targeted Primed T-cells RPTR 168", "d": ["A preparation of genetically modified, multi-antigen-targeted autologous T-lymphocytes, tethered with the human immunostimulatory cytokine interleukin-12 (IL-12), with potential immunostimulating and antineoplastic activities. RPTR 168 is prepared from monocyte-derived dendritic cells (moDCs) that are pulsed with five tumor-associated antigens (TAAs) to expand cytotoxic T-lymphocytes (CTLs) that are subsequently loaded with IL-12. Upon administration, the autologous IL-12/multi-targeted primed T-cells RPTR 168 specifically target tumor cells expressing the five TAAs, which lead to a specific cytotoxic T-lymphocyte (CTL)-mediated killing of these tumor cells. In addition, IL-12 expression activates the immune system by promoting the secretion of interferon-gamma (IFN-g), activating natural killer cells (NKs), and inducing CTL responses, which may further increase tumor cell death and decrease tumor cell proliferation."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1180925", "l": "Corneocyte", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1518754", "l": "Mouse Ovarian Sertoli Cell", "d": []}, {"i": "NCIT:C22665", "l": "Mouse Ovarian Sertoli Cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0546503", "l": "P.B. hemocytoblast", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5706421", "l": "Autologous PD-1-knockout Tumor-infiltrating Lymphocytes IOV-4001", "d": []}, {"i": "NCIT:C187652", "l": "Autologous PD-1-knockout Tumor-infiltrating Lymphocytes IOV-4001", "d": ["A preparation of autologous tumor-infiltrating lymphocytes (TILs) where the programmed cell death protein 1 (PD-1; PDCD1; CD279; programmed death-1) gene has been disrupted using transcription activator-like effector nuclease (TALEN), with potential immunomodulating and antineoplastic activities. The autologous TILs are isolated from an autologous tumor sample, expanded ex-vivo and genetically modified to inactivate PD-1. Upon administration, the autologous PD-1-knockout TILs IOV-4001 induce a T-cell-mediated immune response against tumor cells. Expression of PD-1, an inhibitory receptor expressed on activated T-cells, plays a key role in cytotoxic T-lymphocyte (CTL) suppression, T-cell exhaustion and CTL apoptosis. PD-1 knockout may abrogate T-cell exhaustion and increase T-cell activity and cytotoxicity."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0920751", "l": "Heart cell", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002339", "l": "prostate stem cell", "d": ["A prostate epithelial cell that is CD133-positive, CD44-positive, integrin A2beta3-high. This cell is a stem cell for the prostate epithelium."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C0037888", "l": "Spherocytes", "d": []}, {"i": "NCIT:C12525", "l": "Spherocyte", "d": ["An abnormally small appearing red blood cell that is sphere-shaped and lacks the characteristic central pallor due to cell membrane loss with preservation of cellular contents."]}, {"i": "MESH:D013102", "l": "Spherocytes", "d": []}, {"i": "SNOMEDCT:259682008", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:1001576", "l": "oral mucosa squamous cell", "d": ["Squamous cell of oral epithelium."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1719174", "l": "Cells.CD19+CD27+IgD+", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4068503", "l": "FISH probe target locus", "d": []}]}
{"type": "biolink:Cell", "ic": "87.120474278337809", "identifiers": [{"i": "CL:0002035", "l": "Slamf1-negative multipotent progenitor cell", "d": ["A hematopoietic progenitor that has restricted self-renewal capability. Cell is Kit-positive, Ly6-positive, CD150-negative and Flt3-negative."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0004214", "l": "type 3b cone bipolar cell", "d": ["A type of type 3 cone bipolar cell with distinctive crescent-shaped dendrites."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2330928", "l": "Basal cell of urothelium", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002290", "l": "Y chromosome-bearing sperm cell", "d": ["A sperm bearing a Y chromosome. Chromosomal and genetic sex is established at fertilization in mammals and depends upon whether an X-bearing sperm or a Y-bearing sperm fertilizes the X-bearing ovum."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4243124", "l": "Set of erythropoietic cells", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4038493", "l": "Cells.CD4+CD3-", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002466", "l": "small intestine serosal dendritic cell", "d": ["A CD11b-positive dendritic cell located in the serosal portion of the small intestine epithelium. This cell type is CD45-positive, MHC-II-positive, CD11c-low, CD103-negative."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5418006", "l": "Mozafancogene Autotemcel", "d": []}, {"i": "NCIT:C173602", "l": "Mozafancogene Autotemcel", "d": ["A preparation of autologous CD34+-enriched hematopoietic stem and progenitor cells (HSPCs) from mobilized peripheral blood of patients with Fanconi anemia subtype A (FA-A) that are transduced ex vivo with a lentiviral vector carrying the FANCA gene, with potential to restore FANCA expression and function. Upon re-infusion of mozafancogene autotemcel back into the patient, these cells express functional FANCA gene. Mutations in the FANCA gene, common in patients with FA, prevent normal DNA repair which may lead to chromosomal breakage, increased sensitivity to oxidative and environmental stress, and bone marrow failure."]}]}
{"type": "biolink:Cell", "ic": "79.246894609297499", "identifiers": [{"i": "CL:1000615", "l": "kidney cortex tubule cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4322736", "l": "CD25+ T lymphocyte", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C4724864", "l": "Autologous mRNA-modified Anti-cMET CAR-T Cells", "d": []}, {"i": "NCIT:C148164", "l": "Autologous mRNA-modified Anti-cMET CAR-T Cells", "d": ["A preparation of autologous, genetically-engineered T-lymphocytes that have been electroporated with an mRNA encoding a chimeric antigen receptor (CAR) consisting of an anti-human hepatocyte growth factor receptor (HGFR or cMET) single chain variable fragment (scFv), with potential antineoplastic activities. Upon administration, autologous mRNA-modified anti-cMET CAR-T cells direct T-cells to cMET-expressing tumor cells, which induces selective toxicity against cMET-expressing tumor cells and causes tumor cell lysis. cMET, a receptor tyrosine kinase overexpressed or mutated in many tumor cell types, plays a key role in cancer cell growth, survival, angiogenesis, invasion, and metastasis."]}]}
{"type": "biolink:Cell", "ic": "75.923665061460838", "identifiers": [{"i": "UMLS:C1510728", "l": "Abnormal Keratinocyte", "d": []}, {"i": "NCIT:C36766", "l": "Abnormal Keratinocyte", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0882804", "l": "Cells.CD16c+CD56+", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5153167", "l": "Anulocytes | Blood | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5418107", "l": "Autologous CD19-targeted CAR T Cells CC-97540", "d": []}, {"i": "NCIT:C175049", "l": "Autologous CD19-targeted CAR T Cells CC-97540", "d": ["A preparation of autologous T-lymphocytes that have been genetically modified to express a chimeric antigen receptor (CAR) specific for the tumor-associated antigen (TAA) CD19, with potential immunostimulating and antineoplastic activities. Upon administration, autologous CD19-targeted CAR T cells CC-97540 specifically target and bind to CD19-expressing tumor cells. This results in a cytotoxic T-lymphocyte (CTL) response against CD19-expressing tumor cells and tumor cell lysis. CD19, cluster of differentiation 19, is a B-cell-specific cell surface antigen overexpressed in B-cell lineage tumors."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0000551", "l": "unimodal nocireceptor", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C4733654", "l": "Autologous Mesothelin-specific Human mRNA CAR-transfected PBMCs MCY-M11", "d": []}, {"i": "NCIT:C155775", "l": "Autologous Mesothelin-specific Human mRNA CAR-transfected PBMCs MCY-M11", "d": ["Autologous peripheral blood mononuclear cells (PBMCs) transfected with anti-mesothelin chimeric antigen receptor (CAR) mRNA, with potential antineoplastic activity. Upon intraperitoneal (IP) administration, the autologous mesothelin-specific human mRNA CAR-transfected PBMCs MCY-M11 recognize, bind to, phagocytose and directly kill cancer cells expressing mesothelin. In addition, MCY-M11 stimulates the immune system to induce a cytotoxic T-lymphocyte response against the mesothelin-expressing cancer cells. Mesothelin, a cell surface glycoprotein involved in cell adhesion, is overexpressed in many epithelial-derived cancers."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5216265", "l": "Mesothelial cells|NCnc|Pt|Plr fld", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1507174", "l": "Cells.CD4+CD28+", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5394900", "l": "Entire platelet", "d": []}, {"i": "SNOMEDCT:836278004", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4322828", "l": "Set of corpuscles of colostrum", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5156213", "l": "Burr cells | Blood | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5400722", "l": "Natural Killer Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002555", "l": "fibroblast of mammary gland", "d": ["A fibroblast that is part of the mammary gland."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C4525410", "l": "Alloantigen-specific Allogeneic Type 1 Regulatory T Cells T-allo10", "d": []}, {"i": "NCIT:C134838", "l": "Alloantigen-specific Allogeneic Type 1 Regulatory T Cells T-allo10", "d": ["A preparation of allogeneic CD4+ cells that were ex vivo stimulated with alloantigens, which involves exposing the cells to host antigen-presenting cells (APCs), in the presence of the immunomodulatory cytokine interleukin-10 (IL-10), with potential to prevent graft-versus-host disease (GvHD). The stimulation of the CD4+ cells by exposure to alloantigens plus IL-10 induces the differentiation of alloantigen-specific type 1 T regulatory (TR1) cells, which are hyporesponsive to the alloantigens. Upon infusion of T-allo10 and prior to donor hematopoietic stem cell transplantation (HSCT), the alloantigen-specific type 1 regulatory T-cells are tolerant to the alloantigens and suppress alloreactive immune responses by donor CD4+ and CD8+ T-cells. This may ultimately prevent GvHD. IL-10 plays a key role in controlling inflammation, down-regulating immune responses, and inducing immunological tolerance. IL-10 induces both a long lasting antigen specific T-cell anergy and the differentiation of TR1 cells."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4322674", "l": "CD8+CD56+ NK lymphocyte", "d": []}]}
{"type": "biolink:Cell", "ic": "86.236661114203869", "identifiers": [{"i": "CL:0000563", "l": "endospore", "d": ["A rounded, inactive form that certain bacteria assume under conditions of extreme temperature, dryness, or lack of food. The bacterium develops a waterproof cell wall that protects it from being dried out or damaged."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5180818", "l": "Sezary cells | XXX | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5392177", "l": "Satellite Glia", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5237427", "l": "Autologous CD34-positive Peripheral Blood Stem Cells", "d": []}, {"i": "NCIT:C165750", "l": "Autologous CD34-positive Peripheral Blood Stem Cells", "d": ["A population of autologous cluster of differentiation 34 (CD34)-positive peripheral blood stem cells (PBSCs) that can be used for autologous hematopoietic stem cell transplantation (AHSCT). Upon mobilization and collection of the autologous CD34+ PBSCs by leukapheresis, the CD34+ PBSCs are re-infused into the patient. Upon transplantation, these cells can differentiate into a variety of cell types including the formation of new hematopoietic and immune cells."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1637798", "l": "Leukocyte component of blood", "d": []}, {"i": "SNOMEDCT:419030006", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:1000477", "l": "cardiac pacemaker cell of sinoatrial node", "d": ["A nodal myocyte that is part of the sinoatrial node."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4694618", "l": "Kymriah (Ped ALL)", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1979650", "l": "Blasts.cytoplasmic CD34", "d": []}]}
{"type": "biolink:Cell", "ic": "73.721563224321088", "identifiers": [{"i": "CL:0002369", "l": "fungal spore", "d": ["A differentiated form of a fungus produced during or as a result of an asexual or sexual reproductive process; usually a cell with a thick cell wall that stores and protects one or more nuclei. Spores may be produced in response to, and are characteristically resistant to, adverse environmental conditions."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C2826156", "l": "CD34/TK75 Retroviral Vector-Transduced Donor Lymphocytes", "d": []}, {"i": "NCIT:C82409", "l": "CD34/TK75 Retroviral Vector-Transduced Donor Lymphocytes", "d": ["A preparation of donor T-lymphocytes that are transfected with a retroviral vector encoding a chimeric suicide gene consisting of the extracellular and transmembrane domains of human CD34 and mutant 75 of the herpes simplex virus thymidine kinase (HSV-TK75) with potential controllable immunomodulating activity.  Donor T cell therapy following allogeneic hematopoietic stem cell (HSC) transplantation may result in a graft-versus-leukemia (GVL) and help control transplant-related viral infections. In the event that graft-versus-host disease (GVHD) develops due to donor lymphocyte infusion, CD34/TK75-transduced donor lymphocytes may be selectively eliminated by administration of the prodrug antiviral agent ganciclovir GCV.  In CD34/T75-transduced donor lymphocytes, GCV is phosphorylated by expressed HSV-TK75 to its monophosphate form and, subsequently, converted into its active triphosphate form, which specifically kills the donor lymphocytes.  The expressed CD34 moiety of the chimeric suicide gene serves as a selection marker; mutant 75 of HSV-TK confers increased GCV sensitivity."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5174620", "l": "Neutrophils | Pericardial fluid | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "ic": "83.023198044254755", "identifiers": [{"i": "UMLS:C1516837", "l": "Columnar cell of endocervix", "d": []}, {"i": "NCIT:C33914", "l": "Endocervical Columnar Cell", "d": ["A mucus-producing epithelial cell lining the endocervical lumen."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:4030007", "l": "fallopian tube ciliated cell", "d": ["An epithelial ciliated cell that is part of the fallopian tube. This cell type is found mainly on the apex of the mucosal folds and contributes, together with peristaltic contractions, to the self-propulsion of spermatozoa, the transport of ovum during ovulation and the transport of the fertilized ovum to the intramural fallopian tube. A fallopian tube ciliated cell has a columnar shape and contains an oval or round nucleus, often located perpendicular or parallel to the long axis of the cell."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5706491", "l": "Autologous Anti-CD20CAR-CD28-4-1BB-CD3zeta T-lymphocytes MB-106", "d": []}, {"i": "NCIT:C188358", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002106", "l": "IgD-positive CD38-positive IgG memory B cell", "d": ["An IgD-positive CD38-positive IgG memory B cell is a CD38-positive IgG-positive class switched memory B cell that has class switched and expresses IgD on the cell surface with the phenotype IgD-positive, CD38-positive, and IgG-positive."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5236075", "l": "NSCLC-specific Marrow Infiltrating Lymphocytes", "d": []}, {"i": "NCIT:C164230", "l": "NSCLC-specific Marrow Infiltrating Lymphocytes", "d": ["A preparation of autologous, ex-vivo activated and expanded, bone marrow-derived infiltrating lymphocytes (MILs) from a non-small cell lung cancer (NSCLC) patient, with potential antineoplastic and immunomodulating activities. Upon administration of the NSCLC-specific MILs, the T cells target and destroy the destroy the patient's NSCLC cells."]}]}
{"type": "biolink:Cell", "ic": "58.722923262508068", "identifiers": [{"i": "CL:0000138", "l": "chondrocyte", "d": ["Skeletogenic cell that is terminally differentiated, secretes an avascular, GAG-rich matrix, is embedded in cartilage tissue matrix, retains the ability to divide, and develops from a chondroblast cell."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5700404", "l": "Teb-cel", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5172504", "l": "Mesothelial cells | Cerebral spinal fluid | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C4725915", "l": "Autologous GPC3/NY-ESO-1/AFP specific CD8-positive T-lymphocytes", "d": []}, {"i": "NCIT:C150676", "l": "Autologous GPC3/NY-ESO-1/AFP specific CD8-positive T-lymphocytes", "d": ["A preparation of autologous CD8-positive T-lymphocytes that are exposed, ex vivo, to multiple specific hepatocellular carcinoma (HCC) antigens, including glypican (GPC)-3, New York esophageal squamous cell carcinoma-1 (NY-ESO-1) and alpha-fetoprotein (AFP), with potential immunostimulating and antineoplastic activities. Upon infusion of the GPC3/NY-ESO-1/AFP-specific CD8-positive T lymphocytes, the T-cells specifically target and lyse cells expressing the targeted HCC neoantigens."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C2981826", "l": "Allogeneic CMV/AdV-Specific Cytotoxic T Lymphocytes", "d": []}, {"i": "NCIT:C88310", "l": "Allogeneic CMV/AdV-Specific Cytotoxic T Lymphocytes", "d": ["A population of allogeneic cytotoxic T lymphocytes (CTLs) specifically reactive to cytomegalovirus (CMV) and adenovirus (AdV) with potential antiviral activity. Allogeneic CMV/AdV-specific cytotoxic T lymphocytes are prepared by exposing donor-derived CTLs to a lethally irradiated Epstein-Barr virus-positive lymphoblastoid B cell line (EBV-LCL) that has been transduced with a clinical-grade adenoviral vector (Ad5f35CMVpp65) as a source of CMV and AdV antigens. Infusion of these CTLs into stem cell transplant recipients may prevent CMV and AdV viral disease."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0882842", "l": "Cells.CD3-CD19+", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5669565", "l": "Rebonuputemcel", "d": []}, {"i": "NCIT:C184826", "l": "Rebonuputemcel", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0004228", "l": "broad diffuse amacrine cell", "d": ["An amacrine cell with a small dendritic field that has post-synaptic terminals in S1, S2, S3, and S4."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0229587", "l": "Structure of parathyroid transitional cell", "d": []}, {"i": "SNOMEDCT:15824004", "d": []}]}
{"type": "biolink:Cell", "ic": "80.17194633000733", "identifiers": [{"i": "UMLS:C0018207", "l": "granulosa cell", "d": []}, {"i": "NCIT:C12587", "l": "Granulosa Cell", "d": []}, {"i": "NCIT:C41607", "l": "Ovarian Granulosa Cell", "d": ["A cuboidal cell derived from a spindle-shaped granulosa cell precursor. Initially, ovarian granulosa cells create a single layer surrounding an oocyte. The oocyte and its single layer of ovarian granulosa cells make up a primary follicle. Proliferation of the ovarian granulosa cells leads to multiple cell layers surrounding the oocyte and maturation into a secondary follicle. The granulosa cells extend cytoplasmic processes to form gestational gap-junction-like unions with the plasma membrane of the oocyte. The continued growth of the ovarian granulosa cells takes the oocyte to the Graafian follicle stage. Once ovulation occurs, the granulosa cells become part of the corpus luteum. A major function of an ovarian granulosa cell is hormone production and secretion."]}, {"i": "MESH:D006107", "l": "Granulosa Cells", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4240450", "l": "Vascular smooth muscle cell of arteriole", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1513020", "l": "Mature B-Lymphocyte at the Germinal Center Stage of Differentiation", "d": []}, {"i": "NCIT:C38436", "l": "Mature B-Lymphocyte at the Germinal Center Stage of Differentiation", "d": ["A mature naive B-lymphocyte in the germinal center of secondary lymphoid organ that has had contact with an antigen and a helper T-cell."]}]}
{"type": "biolink:Cell", "ic": "92.728541327098611", "identifiers": [{"i": "CL:0003014", "l": "G11 retinal ganglion cell", "d": ["A mono-stratified retinal ganglion cell that has a large dendritic field, a medium dendritic arbor, and a medium length secondary dendrite shaft."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157560", "l": "CD40 cells | Blood | Cell markers", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C3177154", "l": "Mononuclear+Mesothelial cells", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1184143", "l": "Luminal cell of acinus of lactiferous gland", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1370096", "l": "Cells.CD3+CD8+CD45RO+CD45RA+/100 cells", "d": []}]}
{"type": "biolink:Cell", "ic": "84.128890093485552", "identifiers": [{"i": "CL:0008038", "l": "alpha motor neuron", "d": ["A large, multipolar lower motor neuron of the brainstem and spinal cord that innervates the extrafusal muscle fibers of skeletal muscle and are directly responsible for initiating their contraction. While their cell bodies are in the CNS (in the anterior gray horn of the spinal cord), they are part of the somatic nervous system - a branch of the PNS."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5426632", "l": "Cells.CD3+CD14-CD45+DOCK8+", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1440326", "l": "Cells.CD49f", "d": []}]}
{"type": "biolink:Cell", "ic": "86.236661114203869", "identifiers": [{"i": "CL:4023086", "l": "T Martinotti neuron", "d": ["A Martinotti neuron that has axons that form a horizontal ramification, making it T-shaped."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1507328", "l": "Cells.G0+G1 phase", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1267869", "l": "Lymphocyte positive for both CD11C antigen and CD20 antigen", "d": []}, {"i": "SNOMEDCT:116847007", "d": []}]}
{"type": "biolink:Cell", "ic": "35.626437509584306", "identifiers": [{"i": "CL:0000404", "l": "electrically signaling cell", "d": ["A cell that initiates an electrical signal and passes that signal to another cell."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002663", "l": "myocardial endocrine cell of atrium", "d": ["A myocardial endocrine cell that is part of the atrium."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1440263", "l": "Cells.CD17", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:4023160", "l": "cartwheel cell", "d": ["A neuron of the dorsal cochlear nucleus with spiny dendrites that receive input from the axons of granule cells and with axons that release GABA and glycine onto cartwheel, pyramidal and giant cell targets."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C4688337", "l": "Autologous Anti-CD19 T-cell Receptor T cells ET190L1", "d": []}, {"i": "NCIT:C148030", "l": "Autologous Anti-CD19 T-cell Receptor T cells ET190L1", "d": ["Autologous human peripheral blood T-lymphocytes transduced with a lentivirus encoding a proprietary expression construct composed of a T-cell receptor (TCR)-like human antibody, which is synthesized by a proprietary phage display platform, targeting peptides derived from the tumor-associated antigen (TAA) CD19 that are presented in the context of major histocompatibility complex (MHC) molecules, with potential antineoplastic activity. Following leukapheresis, isolation of lymphocytes, expansion ex vivo, transduction, and re-introduction into the patient, the autologous anti-CD19 TCR T-cells ET190L1 target and bind to tumor cells expressing CD19 peptide/MHC complexes. This results in cytotoxic T-lymphocyte (CTL)-mediated elimination of CD19-positive tumor cells. CD19, cluster of differentiation antigen 19, is a B-cell-specific cell surface antigen overexpressed in B-cell lineage malignancies. ET190L1 is able to match the anticancer activity of chimeric antigen receptor (CAR) T-cells; however, ET190L1 is less likely to stimulate cytokine release syndrome (CRS) and does not cause CAR T-cell-triggered neurotoxicity."]}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "UMLS:C1517726", "l": "Glandular cell of large intestine", "d": []}, {"i": "NCIT:C32925", "l": "Large Intestinal Glandular Cell", "d": ["Intestinal enterocytes are low columnar to cuboidal cells comprising the majority of the epithelial tissue in the intestine and colon. They have both absorptive and secretory functions, absorbing water, sodium and short-chain fatty acids while secreting bicarbonate and potassium. Colonocytes originate from stem cells located at the base of the crypts. Enterocyte production, differentiation, and turnover occurs in topographically distinct regions of crypts. The transformation of colonic epithelial cells are frequently involved in colorectal cancers."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1518043", "l": "Lutzner Cell", "d": []}, {"i": "NCIT:C39648", "l": "Lutzner Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:1000443", "l": "ciliary muscle cell", "d": ["A smooth muscle cell that is part of the ciliary body."]}]}
{"type": "biolink:Cell", "ic": "84.75972595860604", "identifiers": [{"i": "UMLS:C1514036", "l": "Neoplastic Myeloblast with Azurophilic Granules", "d": []}, {"i": "NCIT:C37178", "l": "Neoplastic Myeloblast with Azurophilic Granules", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0009033", "l": "plasma cell of appendix", "d": ["A plasma cell that is located in a vermiform appendix."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:2000076", "l": "hindlimb stylopod vein endothelial cell", "d": ["Any vein endothelial cell that is part of a hindlimb stylopod."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C2717959", "l": "Induced Pluripotent Stem Cells", "d": []}, {"i": "NCIT:C124144", "l": "Induced Pluripotent Stem Cell", "d": ["Adult cells that have been genetically reprogrammed to an embryonic stem cell-like state by the expression of genes and factors important for maintaining the defining properties of embryonic stem cells."]}, {"i": "MESH:D057026", "l": "Induced Pluripotent Stem Cells", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1979638", "l": "Blasts.CD1a", "d": []}]}
{"type": "biolink:Cell", "ic": "51.35289906519975", "identifiers": [{"i": "CL:0002078", "l": "meso-epithelial cell", "d": ["Epithelial cell derived from mesoderm or mesenchyme."]}]}
{"type": "biolink:Cell", "ic": "69.858950277264299", "identifiers": [{"i": "CL:0008024", "l": "pancreatic endocrine cell", "d": ["An endocrine cell that is part of the pancreas."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4300407", "l": "Cells.chromosome 7 monosomy", "d": []}]}
{"type": "biolink:Cell", "ic": "60.824221161029392", "identifiers": [{"i": "CL:0000165", "l": "neuroendocrine cell", "d": ["A neuron that is capable of some hormone secretion in response to neuronal signals."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1181966", "l": "Chromaffin cell of adrenal gland", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0000489", "l": "scotopic photoreceptor cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0440745", "l": "Pigment cell", "d": []}, {"i": "SNOMEDCT:256892003", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C4086003", "l": "Autologous CEA-specific Cytotoxic T-lymphocytes", "d": []}, {"i": "NCIT:C123822", "l": "Autologous CEA-specific Cytotoxic T-lymphocytes", "d": ["Autologous cytotoxic T-lymphocytes (CTLs) specifically reactive to the tumor-associated antigen (TAA) human carcinoembryonic antigen (CEA), with potential antineoplastic activity. Dendritic cells (DCs) isolated from the patient's blood are infected with recombinant adeno-associated virus (AAV) expressing the CEA gene. Exposure of T-lymphocytes to DCs creates CEA-specific CTLs which are expanded. Upon reintroduction of these CTLs into the patient, these cells recognize and kill CEA-expressing tumor cells. CEA, a tumor-associated antigen and a member of the CEA family of proteins, plays a key role in cell migration, cell invasion, and cell adhesion and is overexpressed by a variety of cancer types."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1268443", "l": "Normal cell", "d": []}, {"i": "SNOMEDCT:118957004", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0008010", "l": "Chemoreceptor Cells", "d": []}, {"i": "MESH:D002628", "l": "Chemoreceptor Cells", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2329916", "l": "Fibroblast of outer membrane of prostatic capsule", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2340284", "l": "Differentiated hemal cell", "d": []}]}
{"type": "biolink:Cell", "ic": "70.914165308394445", "identifiers": [{"i": "UMLS:C1514116", "l": "Neoplastic Trophoblastic Cell", "d": []}, {"i": "NCIT:C36803", "l": "Neoplastic Trophoblastic Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002304", "l": "non-pigmented ciliary epithelial cell", "d": ["A cell that is part of non-pigmented ciliary epithelium. This cell type participates in aqueous humor formation by releasing solute, principally sodium and chloride ions received from pigmented epithelial cells via gap junctions, into the aqueous humor of the eye."]}]}
{"type": "biolink:Cell", "ic": "68.095679833930788", "identifiers": [{"i": "CL:0001065", "l": "innate lymphoid cell", "d": ["A lymphocyte that lacks characteristic T cell, B cell, myeloid cell, and dendritic cell markers, that functions as part of the innate immune response to produce cytokines and other effector responses."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0599757", "l": "M Cells", "d": []}, {"i": "MESH:D000092303", "l": "M Cells", "d": []}]}
{"type": "biolink:Cell", "ic": "63.271958778998595", "identifiers": [{"i": "UMLS:C1515138", "l": "Precursor T-Lymphoblast", "d": []}, {"i": "NCIT:C33930", "l": "Precursor T-Lymphoblast", "d": ["An immature T-lymphocyte, that has enlarged following stimulation by an antigen, has the capacity to recognize the stimulating antigen and is undergoing proliferation and differentiation either to eliminate the antigen or to a memory state in order to recognize the future appearance of the antigen."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1267843", "l": "Lymphocyte positive for both CD4 antigen and CD8 antigen", "d": []}, {"i": "SNOMEDCT:117530008", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1257912", "l": "Haploid Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C4524566", "l": "Hematopoietic Progenitor Cells from Cord Blood", "d": []}, {"i": "NCIT:C133329", "l": "Hematopoietic Progenitor Cells from Cord Blood", "d": ["Blood collected from the umbilical cord as a source of hematopoietic progenitor cells."]}]}
{"type": "biolink:Cell", "ic": "83.552982069901191", "identifiers": [{"i": "CL:1000279", "l": "smooth muscle cell of large intestine", "d": ["A smooth muscle cell that is part of the large intestine."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0000971", "l": "IgM memory B cell", "d": ["An IgM memory B cell is an unswitched memory B cell with the phenotype IgM-positive and IgD-negative."]}]}
{"type": "biolink:Cell", "ic": "92.728541327098611", "identifiers": [{"i": "CL:0002025", "l": "CD34-positive, CD41-positive, CD42-negative megakaryocyte progenitor cell", "d": ["A megakaryocyte progenitor cell that is CD34-positive, CD41-positive, and CD42-negative."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1507329", "l": "Cells.t(6;9)(p22;q34)(DEK,NUP214)", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2337324", "l": "Glandular cell of prostate", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0000705", "l": "R6 photoreceptor cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5571779", "l": "Siderocytes.Type 1", "d": []}]}
{"type": "biolink:Cell", "ic": "89.347505587204751", "identifiers": [{"i": "CL:0011101", "l": "chorionic trophoblast cell", "d": ["Cells of the uterine chorion that acquire specialized structural and/or functional features that characterize chorionic trophoblasts. These cells will migrate towards the spongiotrophoblast layer and give rise to syncytiotrophoblasts of the labyrinthine layer."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002513", "l": "Vgamma5-positive CD8alpha alpha positive gamma-delta intraepithelial T cell", "d": ["A CD8alpha alpha positive gamma-delta intraepithelial T cell that expresses a TCR encoded in part by the Vgamma5 gene segment."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5178307", "l": "Promyelocytes | Body fluid | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C2986402", "l": "Anti-CTLA4 MoAb RNA-transfected Autologous Dendritic Cell Vaccine", "d": []}, {"i": "NCIT:C94217", "l": "Anti-CTLA4 MoAb RNA-transfected Autologous Dendritic Cell Vaccine", "d": ["An autologous dendritic cell (DC) cancer vaccine with potential immunostimulatory activity. Anti-CTLA4 MoAb RNA-transfected autologous DC vaccine is prepared by transfecting DCs with RNAs encoding humanized heavy and light chains of the anti-CTLA4 (cytotoxic T-Lymphocyte-Associated Antigen 4); expression of anti-CTLA4 blocks the inhibitory effect of CTLA4 on the activation of T-lymphocytes. Co-vaccination of this vaccine with melanoma antigen specific vaccine may eliminate the adverse effects associated with systemic administration of immune modulators, while also enhancing vaccine-induced immune responses."]}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "UMLS:C1516901", "l": "Eosinophilic Meningothelial Cell", "d": []}, {"i": "NCIT:C37159", "l": "Eosinophilic Meningothelial Cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1179787", "l": "Vacuolar absorptive cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2325541", "l": "Fibroblast of dense regular elastic tissue", "d": []}]}
{"type": "biolink:Cell", "ic": "82.076046914303362", "identifiers": [{"i": "UMLS:C1710694", "l": "Xanthomatous Cell", "d": []}, {"i": "NCIT:C49071", "l": "Xanthomatous Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "92.728541327098611", "identifiers": [{"i": "CL:0000318", "l": "sweat secreting cell", "d": ["A cell secreting sweat, the fluid excreted by the sweat glands of mammals. It consists of water containing sodium chloride, phosphate, urea, ammonia, and other waste products."]}]}
{"type": "biolink:Cell", "ic": "92.728541327098611", "identifiers": [{"i": "UMLS:C1882060", "l": "Neoplastic Small Epithelial Cell with Scant Amount of Cytoplasm", "d": []}, {"i": "NCIT:C61296", "l": "Neoplastic Small Epithelial Cell with Scant Amount of Cytoplasm", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0682634", "l": "Leukocyte precursor", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5555048", "l": "Allogeneic Natural Killer Cells PB103", "d": []}, {"i": "NCIT:C178455", "l": "Allogeneic Natural Killer Cells PB103", "d": ["A preparation of allogeneic, natural killer (NK) cells, with potential cytolytic and antineoplastic activities. Upon administration, allogeneic NK cells PB103 may lyse cancer cells. These cells also secrete pro-inflammatory cytokines, which further stimulate an anti-tumor immune response."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5556547", "l": "ECT204 Transgene-transduced Autologous T Cells ECT204", "d": []}, {"i": "NCIT:C180673", "l": "ECT204 Transgene-transduced Autologous T Cells ECT204", "d": ["A preparation of autologous human T-lymphocytes transduced with a lentiviral vector expressing the ECT204 transgene that encodes an antibody-based antigen-binding domain targeting the tumor-associated antigen (TAA) glypican-3 (GPC3) and an effector-binding domain, with potential immunomodulating and antineoplastic activities. Following leukapheresis, isolation of lymphocytes, expansion ex vivo, transduction, and re-introduction into the patient, the ECT204 transgene-transduced autologous T cells ECT204 target and bind to tumor cells expressing GPC3. This results in cytotoxic T-lymphocyte (CTL)-mediated elimination of GPC3-positive tumor cells. GPC3, a heparan sulfate proteoglycan and a member of the glypican family, is overexpressed on certain tumor cell types while minimally expressed on normal, healthy cells. GPC3 plays an important role in cellular proliferation and differentiation.Compared to conventional CAR T-cells, ECT204 may be less likely to stimulate cytokine release syndrome (CRS) and other cytokine-mediated toxicities."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C3898559", "l": "MAGE-A3/12-specific TCR Gene-transduced Autologous PBLs", "d": []}, {"i": "NCIT:C116862", "l": "MAGE-A3/12-specific TCR Gene-transduced Autologous PBLs", "d": ["Human autologous peripheral blood lymphocytes (PBLs) transduced with a retroviral vector encoding a T-cell receptor (TCR) that recognizes the human melanoma antigens A3 and A12 (MAGE-A3/12), with potential antineoplastic activity. Upon isolation, transduction, expansion ex vivo, and reintroduction into the patient, the MAGE-A3/12-specific TCR gene-transduced autologous PBLs bind to and lyse tumor cells expressing MAGE-A3/12, which may halt the growth of MAGE-A3/12-expressing cancer cells. MAGE-A3 and MAGE-A12, tumor associated antigens and members of the melanoma-associated antigen gene family, are overexpressed by a variety of cancer cell types."]}]}
{"type": "biolink:Cell", "ic": "90.82444074280258", "identifiers": [{"i": "CL:0000857", "l": "slow muscle myoblast", "d": ["A skeletal muscle myoblast that differentiates into slow muscle fibers."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157470", "l": "CD3+HLA-DR+ cells | XXX | Cell markers", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4246843", "l": "Cranial neural crest cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1267954", "l": "Lymphocyte positive for CD62L antigen", "d": []}, {"i": "SNOMEDCT:117395004", "d": []}]}
{"type": "biolink:Cell", "ic": "82.076046914303362", "identifiers": [{"i": "UMLS:C1519112", "l": "Round Striated Muscle Cell", "d": []}, {"i": "NCIT:C36950", "l": "Round Striated Muscle Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:2000082", "l": "melanocyte of foreskin", "d": ["Any melanocyte of skin that is part of a skin of prepuce of penis."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157544", "l": "CD4+CD45RA+ cells | Blood | Cell markers", "d": []}]}
{"type": "biolink:Cell", "ic": "89.347505587204751", "identifiers": [{"i": "UMLS:C1519424", "l": "Somatotrophs", "d": []}, {"i": "NCIT:C33578", "l": "Somatotroph Cell", "d": ["An acidophil of the adenohypophysis that stains preferentially with orange G and secretes growth hormone."]}, {"i": "MESH:D052683", "l": "Somatotrophs", "d": []}]}
{"type": "biolink:Cell", "ic": "82.532694649739099", "identifiers": [{"i": "CL:0005020", "l": "lymphangioblast", "d": ["Lymphatic progenitor cells."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:2000079", "l": "mesenchymal stem cell of femoral bone marrow", "d": ["Any mesenchymal stem cell of the bone marrow that is part of a femur."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1513816", "l": "NC03", "d": []}, {"i": "NCIT:C20283", "l": "NC03", "d": ["Provider: National Centre for Biological Sciences/ Tata Institute of Fundamental Research, Bangalore, India. No information from provider. This cell line meets the criteria for the use of human embryonic stem cells by federally funded researchers."]}]}
{"type": "biolink:Cell", "ic": "92.728541327098611", "identifiers": [{"i": "CL:0003030", "l": "M3 retinal ganglion cell", "d": ["A monostratified retinal ganglion cell that has a medium soma and a small dendrite field."]}]}
{"type": "biolink:Cell", "ic": "92.728541327098611", "identifiers": [{"i": "CL:0002268", "l": "P/D1 enteroendocrine cell", "d": ["An enteroendocrine cell that stores and secretes Ghrelin."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C4687587", "l": "NY-ESO-1 TCR Retroviral Vector-transduced Autologous PBMCs", "d": []}, {"i": "NCIT:C146939", "l": "NY-ESO-1 TCR Retroviral Vector-transduced Autologous PBMCs", "d": ["Human autologous peripheral blood mononuclear cells (PBMCs) transduced with a retroviral vector (RV) encoding a T-cell receptor (TCR) specific for the cancer-testis antigen NY-ESO-1, with potential immunostimulating and antineoplastic activities. Upon isolation, transduction, expansion ex vivo, and reintroduction into the patient, the NY-ESO-1 TCR RV-transduced autologous PBMCs recognize and bind to NY-ESO-1-overexpressing tumor cells. This may result in a specific cytotoxic T-lymphocyte (CTL)-mediated killing of NY-ESO-1-positive tumor cells. NY-ESO-1, a tumor associated antigen (TAA), is found in normal testis and on the surface of various tumor cell types."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1272578", "l": "Skin fibroblast", "d": []}, {"i": "SNOMEDCT:386121006", "d": []}]}
{"type": "biolink:Cell", "ic": "92.728541327098611", "identifiers": [{"i": "CL:0002477", "l": "adipose macrophage", "d": ["A macrophage located in adipose tissue that is CD45-positive, CD11c-positive, and SIRPa-positive."]}]}
{"type": "biolink:Cell", "ic": "84.75972595860604", "identifiers": [{"i": "CL:0000695", "l": "Cajal-Retzius cell", "d": ["A neuron of the human embryonic marginal zone which display, as a salient feature, radial ascending processes that contact the pial surface, and a horizontal axon plexus located in the deep marginal zone. One feature of these cells in mammals is that they express the Reelin gene."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C4744926", "l": "Bone Marrow Mononuclear Cell", "d": []}, {"i": "NCIT:C156591", "l": "Bone Marrow Mononuclear Cell", "d": ["Any cell with a single nucleus found in the bone marrow, for example lymphocytes, monocytes, mesenchymal stem cells and hematopoietic progenitor cells."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157452", "l": "CD3+CD57+ cells | Blood | Cell markers", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0009096", "l": "esophagus non-keratinized squamous epithelial cell", "d": ["Any cell that is part of the esophageal non-keratinized stratified squamous epithelium. In humans, the esophagus, which requires flexibility to accommodate swallowing of a bolus, is covered with a non-keratinized epithelium."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0229426", "l": "Secondary sclerotic mastoid cell", "d": []}, {"i": "SNOMEDCT:57106004", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0000969", "l": "regulatory B cell", "d": ["A mature B cell that has the phenotype CD1d-positive and expresses interleukin-10. This cell type has been associated with suppression of chronic inflammatory responses and T cell responses."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0333844", "l": "Flaming plasma cell", "d": []}, {"i": "SNOMEDCT:81739009", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C0949667", "l": "Hurthle Cells", "d": []}, {"i": "NCIT:C33925", "l": "Thyroid Gland Oxyphil Cell", "d": ["A large, granular eosinophilic cell derived from thyroid follicular epithelium by accumulation of mitochondria"]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4322734", "l": "FMC-7+ B lymphocyte", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4696688", "l": "Cells.CD19+CD27+IgD-IgM+", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5420606", "l": "MAGE-A1-specific T Cell Receptor-transduced Autologous T-cells", "d": []}, {"i": "NCIT:C174139", "l": "MAGE-A1-specific T Cell Receptor-transduced Autologous T-cells", "d": ["A preparation of autologous CD4- and CD8-positive T-lymphocytes genetically modified to express a T-cell receptor (TCR) that specifically targets the human melanoma-associated antigen A1 (MAGE-A1), with potential antineoplastic activity. Upon isolation, transduction, expansion ex vivo, and reintroduction into the patient, the MAGE-A1-specific TCR-transduced autologous T-cells bind to tumor cells expressing MAGE-A1, which may halt the growth of and kill MAGE-A1-expressing cancer cells. MAGE-A1 is a tumor-associated antigen (TAA) overexpressed by a variety of cancer cell types."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0334140", "l": "Rod shaped microglia", "d": []}, {"i": "SNOMEDCT:42723004", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C3898837", "l": "Hsp70-peptide TKD/IL-2-activated Autologous Natural Killer Cells", "d": []}, {"i": "NCIT:C115969", "l": "Hsp70-peptide TKD/IL-2-activated Autologous Natural Killer Cells", "d": ["A preparation of autologous natural killer (NK) cells that are stimulated ex vivo by a 14-mer heat shock protein 70 (Hsp70) TKD peptide and interleukin-2 (IL-2), with potential tumor-selective cytolytic activity. Upon re-infusion into the patient, the treated NK cells recognize and bind to Hsp70-expressing tumor cells, which induces NK-mediated tumor cell lysis. Hsp70, a membrane-bound, stress-inducible protein, is overexpressed on almost all tumor cells; however, it is absent or minimally present on normal, healthy cells. TKD is the C-terminal substrate-binding domain of Hsp70 and is the structure recognized by the activated NK cells."]}]}
{"type": "biolink:Cell", "ic": "83.552982069901191", "identifiers": [{"i": "CL:0002548", "l": "fibroblast of cardiac tissue", "d": ["A fibroblast that is part of the heart."]}]}
{"type": "biolink:Cell", "ic": "49.093739228100041", "identifiers": [{"i": "UMLS:C1518245", "l": "Malignant Squamous Cell", "d": []}, {"i": "NCIT:C36771", "l": "Malignant Squamous Cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4300405", "l": "Cells.chromosome region 13q14", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2339342", "l": "Set of A14 dopaminergic cells", "d": []}]}
{"type": "biolink:Cell", "ic": "90.82444074280258", "identifiers": [{"i": "CL:1001569", "l": "hippocampal interneuron", "d": ["An interneuron with a soma found in the hippocampus."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2327016", "l": "Type I cell of adrenal cortex", "d": []}]}
{"type": "biolink:Cell", "ic": "58.920120576733368", "identifiers": [{"i": "CL:0000150", "l": "glandular epithelial cell", "d": ["A specialized epithelial cell that is capable of synthesizing and secreting certain biomolecules."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002624", "l": "paneth cell of the appendix", "d": ["A paneth cell of the appendix."]}]}
{"type": "biolink:Cell", "ic": "88.140761698499901", "identifiers": [{"i": "CL:4023075", "l": "L6 th sst GABAergic interneuron (Mmus)", "d": ["A sst GABAergic cortical interneuron found in L6 that expresses tyrosine hydroxylase. L6 Th+ SST cells have mostly local axonal arborization within L6."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1179047", "l": "Myoepithelial cell of intralobular lactiferous duct", "d": []}]}
{"type": "biolink:Cell", "ic": "92.728541327098611", "identifiers": [{"i": "UMLS:C0029431", "l": "Osteoclasts", "d": []}, {"i": "NCIT:C12570", "l": "Osteoclast", "d": ["A large, multinucleated cell that secretes bone-degrading enzymes in the processes of normal bone remodeling and pathological bone loss. Osteoclasts are derived from macrophages."]}, {"i": "MESH:D010010", "l": "Osteoclasts", "d": []}, {"i": "SNOMEDCT:27770000", "d": []}]}
{"type": "biolink:Cell", "ic": "92.728541327098611", "identifiers": [{"i": "CL:0002171", "l": "globose cell of olfactory epithelium", "d": ["A rounded or elliptical epithelial cell, with pale-staining open face nucleus and pale cytoplasm rich in free ribosomes and clusters of centrioles; form a distinct basal zone spaced slightly from the basal surface of the epithelium."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5161800", "l": "Cytoplasmic CD22 blasts | XXX | Cell markers", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:4033030", "l": "diffuse bipolar 3b cell", "d": ["An OFF calbindin-negative bipolar cell that has a large dendritic field and stratifies narrowly close to the middle of the inner plexiform layer. Its axon terminal is characterized by regularly branching and varicose processes resembling beads on a string. Most of DB3b contacts with cones are non-triad-associated."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1267883", "l": "Lymphocyte positive for CD17 antigen", "d": []}, {"i": "SNOMEDCT:117560003", "d": []}]}
{"type": "biolink:Cell", "ic": "71.335885432862128", "identifiers": [{"i": "UMLS:C1514082", "l": "Neoplastic Sertoli Cell", "d": []}, {"i": "NCIT:C36895", "l": "Neoplastic Sertoli Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "CL:0002671", "l": "endothelial stalk cell", "d": ["An endothelial stalk cell is a specialized endothelial cell that follows behind the tip cell of an angiogenic sprout."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C0524980", "l": "Enterochromaffin-like Cells", "d": []}, {"i": "NCIT:C12576", "l": "Enterochromaffin-Like Cell", "d": ["A type of enteroendocrine cell located in the oxyntic glands of the stomach that releases histamine in regulation of acid secretion. It is morphologically similar to enterochromaffin cells, but lacks an affinity to binding silver salts."]}, {"i": "MESH:D019861", "l": "Enterochromaffin-like Cells", "d": []}, {"i": "SNOMEDCT:14099006", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1180330", "l": "Globose cell of olfactory epithelium", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1183180", "l": "Set of aminergic cells in compact part of substantia nigra [A9]", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:1000311", "l": "adipocyte of epicardial fat of left ventricle", "d": ["A fat cell that is part of the epicardial fat of left ventricle."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C4330672", "l": "Membrane-bound Interleukin-21-Expanded Haploidentical Natural Killer Cells", "d": []}, {"i": "NCIT:C131901", "l": "Membrane-bound Interleukin-21-Expanded Haploidentical Natural Killer Cells", "d": ["A preparation of human cytokine interleukin-21 (IL-21) primed, tumor-activated allogeneic human leukocyte antigen (HLA) haploidentical natural killer (NK) cells, with potential cytolytic and immunoregulatory activities. Allogeneic leukemia cells are genetically modified to express membrane-bound interleukin-21 (mbIL-21) on their cell surfaces. When human peripheral blood mononuclear cells (PBMCs) from an HLA-haploidentical donor are subsequently exposed to these cells, the donor PBMC differentiate into mature, highly cytotoxic NK cells, which are subsequently expanded in ex vivo culture.  Upon infusion of the mbIL-21-expanded haploidentical NK cells, the NK cells target, lyse and destroy tumor cells. mbIL-21 promotes sustained ex vivo proliferation of human NK cells and enhances its cytotoxic activity."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C3656689", "l": "B cell+T cell", "d": []}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "UMLS:C1709181", "l": "Neoplastic Lactotroph Cell with Small Secretory Granules", "d": []}, {"i": "NCIT:C45953", "l": "Neoplastic Lactotroph Cell with Small Secretory Granules", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1513376", "l": "Moderately Differentiated Adenocarcinoma Cell", "d": []}, {"i": "NCIT:C36797", "l": "Moderately Differentiated Adenocarcinoma Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "92.728541327098611", "identifiers": [{"i": "UMLS:C1708948", "l": "Mature Tissue Histiocyte", "d": []}, {"i": "NCIT:C43249", "l": "Mature Tissue Histiocyte", "d": ["A macrophage found in connective tissue. It is part of the reticuloendothelial system. The primary function of a mature tissue histiocyte is to phagocytose and digest tissue fragments especially apoptotic bodies and those fragments resulting from tissue injury and death."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:1001221", "l": "arcuate vein smooth muscle cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0882828", "l": "Cell positive for CD3 antigen", "d": []}, {"i": "SNOMEDCT:116744006", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5154300", "l": "Band form neutrophils | Fetus | Blood | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "ic": "68.368095522595297", "identifiers": [{"i": "UMLS:C1514103", "l": "Neoplastic Striated Muscle Cell", "d": []}, {"i": "NCIT:C36947", "l": "Neoplastic Striated Muscle Cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1184138", "l": "Myoepithelial cell of primary lactiferous duct", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C4288083", "l": "Type-1 Polarized Dendritic Cell-induced Antigen-specific Autologous Cytotoxic T Lymphocytes", "d": []}, {"i": "NCIT:C128892", "l": "Type-1 Polarized Dendritic Cell-induced Antigen-specific Autologous Cytotoxic T Lymphocytes", "d": ["A preparation of autologous cytotoxic T-lymphocytes (CTL), specifically reactive to melanoma-associated antigen 3 (MAGE-3), MAGE-4, survivin, human epidermal growth factor receptor 2 (HER2; ERBB2) and cyclooxygenase-2 (COX-2), with potential immunomodulating activity. Peripheral blood mononuclear cells (PBMCs) are collected from the patient. Subsequently, autologous dendritic cells (DCs) are separated, treated with a certain combination of cytokines to produce polarized type-1 DCs (DC1), and then are loaded with MAGE-3/MAGE-4/survivin/HER2/COX-2 CTL epitope peptides. In turn, autologous CTLs are collected, exposed ex vivo to the antigen-loaded DC1s and subsequently expanded in vitro. Upon re-infusion of the DC1-induced MAGE-3/MAGE-4/survivin/HER2/COX-2-specific autologous CTLs, the CTLs target and lyse tumor cells expressing the tumor-associated antigens (TAAs). Exposure to DC1s generates more potent CTLs and thus induces a more potent CTL response against TAA-expressing tumor cells. The targeted TAAs play key roles in cellular proliferation and are overexpressed by a variety of cancer cell types."]}]}
{"type": "biolink:Cell", "ic": "73.847638787057321", "identifiers": [{"i": "UMLS:C1514106", "l": "Neoplastic Syncytiotrophoblastic Cell", "d": []}, {"i": "NCIT:C36906", "l": "Neoplastic Syncytiotrophoblastic Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "50.355743568050826", "identifiers": [{"i": "CL:0000003", "l": "obsolete native cell", "d": ["OBSOLETE. A cell that is found in a natural setting, which includes multicellular organism cells 'in vivo' (i.e. part of an organism), and unicellular organisms 'in environment' (i.e. part of a natural environment)."]}]}
{"type": "biolink:Cell", "ic": "81.648881485605159", "identifiers": [{"i": "CL:0002370", "l": "respiratory goblet cell", "d": ["A simple columnar epithelial cell that secretes mucin. Rough endoplasmic reticulum, mitochondria, the nucleus, and other organelles are concentrated in the basal portion. The apical plasma membrane projects microvilli to increase surface area for secretion."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5666873", "l": "Allogeneic Anti-BCMA CAR T Cells ALLO-605", "d": []}, {"i": "NCIT:C182066", "l": "Allogeneic Anti-BCMA CAR T Cells ALLO-605", "d": ["A preparation of allogeneic, transcription activator-like effector nuclease (TALEN)-engineered, gene-edited T-lymphocytes that have been transduced with a lentiviral vector expressing a chimeric antigen receptor (CAR) targeting the human tumor-associated antigen (TAA) B-cell maturation antigen (BCMA; tumor necrosis factor receptor superfamily member 17; TNFRSF17) and engineered to express a constitutively active chimeric cytokine receptor (CACCR), with potential immunostimulating and antineoplastic activities. Using TALEN technology, the T-cell receptor (TCR) alpha chain (TRAC) and CD52 genes are inactivated. Upon administration, the allogeneic anti-BCMA CAR T Cells ALLO-605 specifically recognize and induce selective toxicity in BCMA-expressing tumor cells. BCMA, a receptor for both a proliferation-inducing ligand (APRIL) and B-cell activating factor (BAFF), is a member of the tumor necrosis factor receptor superfamily (TNFRSF). BCMA is found on the surfaces of plasma cells, is overexpressed on malignant plasma cells and plays a key role in plasma cell proliferation and survival. Inactivation of the CD52 gene makes the modified donor T-cells resistant to an anti-CD52 monoclonal antibody treatment, that is used during lymphodepletion. The knockout of TRAC eliminates TCR expression and is intended to abrogate the potential induction of graft-versus-host disease (GvHD) by the donor T-cells. The expression of CACCR allows for intracellular cytokine activation signaling, which may enhance expansion and persistence of the CAR T cells, thereby improving long-term anti-tumor activity. In addition, the incorporated CD20-based off-switch of ALLO-605 permits selective depletion of the ALLO-605 cells when the anti-CD20 monoclonal antibody rituximab is administered. ALLO-605 can also be inactivated with dasatinib."]}]}
{"type": "biolink:Cell", "ic": "85.457082654197222", "identifiers": [{"i": "CL:0002664", "l": "cardioblast", "d": ["A stem cell that can give rise to multiple cell types (i.e. smooth muscle, endothelial) in the developing heart."]}]}
{"type": "biolink:Cell", "ic": "90.82444074280258", "identifiers": [{"i": "CL:0001040", "l": "non-terminally differentiated osteoblast", "d": ["Osteoblast that is non-terminally differentiated and located in cellular bone tissue or under the periosteum in acellular bone."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1179672", "l": "Stem cell of intestinal crypt of Lieberkuhn", "d": []}]}
{"type": "biolink:Cell", "ic": "66.748105804263417", "identifiers": [{"i": "CL:0000468", "l": "neuroglioblast (sensu Nematoda and Protostomia)", "d": ["A precursor of the central nervous system that gives rise to both neurons and glial cells."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5426795", "l": "Alveolar macrophages | Lower respiratory specimen | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5557273", "l": "Allogeneic CD19-OX40-CD3zeta-CAR-mbIL-15-expressing Natural Killer Cells NKX019", "d": []}, {"i": "NCIT:C181804", "l": "Allogeneic CD19-OX40-CD3zeta-CAR-mbIL-15-expressing Natural Killer Cells NKX019", "d": ["A preparation of off-the-shelf (OTS), allogeneic and ex vivo expanded natural killer cells (NKs) that are engineered to express membrane-bound IL-15 (mbIL15) and a chimeric antigen receptor (CAR) targeting the tumor-associated antigen (TAA) CD19 that is coupled to the co-stimulatory domain of OX40 (CD134), and to the zeta chain of the TCR/CD3 complex (CD3-zeta; CD3zeta), with potential immunomodulating and antineoplastic activities. Upon administration of allogeneic CD19-OX40-CD3zeta-CAR-mbIL-15-expressing NK cells NKX019, these cells specifically target and bind to tumor cells expressing CD19. This induces secretion of pro-inflammatory cytokines and results in the lysis of CD19-expressing tumor cells. IL-15 is a pro-survival cytokine that potentiates the immune response against tumor cells. CD19 antigen is a B-cell specific cell surface antigen expressed in all B-cell lineage malignancies."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1440230", "l": "Cells.aneuploid.population 2", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4512518", "l": "Entire infantile diploetic mastoid cell", "d": []}, {"i": "SNOMEDCT:727281006", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1515108", "l": "Syncytiotrophoblast cell", "d": []}, {"i": "NCIT:C38574", "l": "Syncytiotrophoblastic Cell", "d": ["A large, multinucleated cell having hyperchromatic nuclei and abundant eosinophilic, sometimes vacuolated cytoplasm, in the outer syncytial layer of the trophoblast."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5446533", "l": "Autologous PD1-knockout CD19-specific CAR T Cells", "d": []}, {"i": "NCIT:C175452", "l": "Autologous PD1-knockout CD19-specific CAR T Cells", "d": ["A preparation of autologous CD4+ and CD8+ T-lymphocytes gene-edited to integrate a chimeric antigen receptor (CAR) targeting the tumor-associated antigen (TAA) CD19 and to eliminate the programmed cell death 1 (PD-1; PDCD1; CD279; programmed death-1) gene, with potential immunomodulating and antineoplastic activities. Upon administration, autologous PD1-knockout CD19-specific CAR T cells specifically target and bind to CD19-expressing tumor cells, thereby selectively lysing CD19-expressing tumor cells. CD19 antigen is a B-cell specific cell surface antigen overexpressed in B-cell lineage malignancies. Expression of PD-1, an inhibitory receptor expressed on activated T-cells, plays a key role in CTL suppression, T-cell exhaustion and CTL apoptosis. PD-1 knockout may abrogate T-cell exhaustion and increase T-cell activity and cytotoxicity."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002263", "l": "transitional cell of parathyroid gland", "d": ["One of three types of epithelial cells that populate the parathyroid gland; cytological characteristics intermediate between those of the chief cell and of the oxyphil cell. Because only one hormone is produced, the three cell forms are widely believed to be different phases in the life cycle of a single cell type, with the chief cell being its physiologically active stage."]}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "CL:0000238", "l": "non keratinizing barrier epithelial cell", "d": []}]}
{"type": "biolink:Cell", "ic": "53.733121520109748", "identifiers": [{"i": "UMLS:C1519221", "l": "Secretory cell", "d": []}, {"i": "NCIT:C13055", "l": "Secretory Cell", "d": ["One of several types of cells that generate and secrete a substance to be used by the organism."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C0206513", "l": "Type 2 vestibular sensory cell", "d": []}, {"i": "NCIT:C12631", "l": "Type II Hair Cell", "d": ["A cylinder-shaped mechanoreceptor cell that detects and transduces head movements into neural impulses and is located within the vestibular systems of all vertebrates."]}, {"i": "SNOMEDCT:17012008", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1518009", "l": "Low Columnar Cell", "d": []}, {"i": "NCIT:C33008", "l": "Low Columnar Cell", "d": ["A simple epithelial cell that is shaped like a short column."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157425", "l": "CD3 cells | Bone marrow | Cell markers", "d": []}]}
{"type": "biolink:Cell", "ic": "77.488267285704651", "identifiers": [{"i": "CL:0000825", "l": "pro-NK cell", "d": ["A lymphoid progenitor cell that is committed to the natural killer cell lineage, expressing CD122 (IL-15) receptor, but lacking many of the phenotypic characteristics of later stages of natural killer cell development such as expression of NK activating and inhibitory molecules. In human this cell has the phenotype CD34-positive, CD45RA-positive, CD10-positive, CD117-negative, and CD161 negative."]}]}
{"type": "biolink:Cell", "ic": "90.82444074280258", "identifiers": [{"i": "UMLS:C1512638", "l": "Immature Peripheral Gamma/Delta Cell of Cytotoxic Type", "d": []}, {"i": "NCIT:C38326", "l": "Immature Peripheral Gamma/Delta Cell of Cytotoxic Type", "d": ["A cell derived from stem cells in the bone marrow. It is a maturing T lymphocyte that expresses a gamma-delta antigen specific surface receptor (TCR). These cells exert major histocompatibility-unrestricted natural cytotoxicity against several types of solid tumors and some leukemias and lymphomas. They are also involved in the immune response to certain infections and are able to mediate antibody-dependent cytotoxicity and are not alloreactive."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2336257", "l": "Pleural macrophage", "d": []}]}
{"type": "biolink:Cell", "ic": "75.26123597683771", "identifiers": [{"i": "UMLS:C0814005", "l": "Neuroblast", "d": []}, {"i": "NCIT:C12991", "l": "Neuroblast", "d": ["An embryonic nerve cell capable of differentiating into a neuron."]}]}
{"type": "biolink:Cell", "ic": "88.140761698499901", "identifiers": [{"i": "UMLS:C0016390", "l": "Foam Cells", "d": []}, {"i": "NCIT:C12560", "l": "Foam Cell", "d": ["A type of macrophage that ingests low-density lipoproteins found in fatty deposits on blood vessel walls, resulting in a foamy appearance."]}, {"i": "MESH:D005487", "l": "Foam Cells", "d": []}, {"i": "SNOMEDCT:16980002", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1518683", "l": "Cochlear outer hair cell", "d": []}, {"i": "NCIT:C33233", "l": "Outer Hair Cell of the Organ of the Corti", "d": ["A cell situated on one of three of the most outer layers of the basilar membrane of the cochlea. Each cell has multiple, sensitive strands called stereocilia. In the resting state the stereocilia are leaning on each other in a conical bundle and are embedded in the tectorial membrane. When the cochlea moves in response to sound, a slight shearing force occurs between the basilar and tectorial membranes, the stereocilia bend and send electrical impulses to the brain via the eighth cranial nerve."]}, {"i": "MESH:D018072", "l": "Hair Cells, Auditory, Outer", "d": []}, {"i": "SNOMEDCT:43313002", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1518247", "l": "Malignant Tadpole Squamous Cell", "d": []}, {"i": "NCIT:C36776", "l": "Malignant Tadpole Squamous Cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4240445", "l": "Vascular smooth muscle cell of aorta", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1254546", "l": "Anisocyte (cell)", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4518147", "l": "Population of all spermatozoa with cytoplasmic droplet in portion of fluid", "d": []}, {"i": "SNOMEDCT:725252006", "d": []}]}
{"type": "biolink:Cell", "ic": "92.728541327098611", "identifiers": [{"i": "CL:1001607", "l": "articular chondrocyte", "d": ["Chondrocyte forming the hyaline cartilage found in joints."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1182665", "l": "Internal epithelial cell of tympanic membrane", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1519265", "l": "Mouse Testis Sertoli Cell", "d": []}, {"i": "NCIT:C22183", "l": "Mouse Testis Sertoli Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "83.552982069901191", "identifiers": [{"i": "UMLS:C1880478", "l": "Eccrine Adenocarcinoma Cell", "d": []}, {"i": "NCIT:C62497", "l": "Eccrine Adenocarcinoma Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "89.347505587204751", "identifiers": [{"i": "UMLS:C1513173", "l": "Metaplastic Glandular Cell", "d": []}, {"i": "NCIT:C36837", "l": "Metaplastic Glandular Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:4023056", "l": "vascular leptomeningeal cell (Mmus)", "d": ["A type of mouse mesothelial fibroblast that is derived from the neural crest, is localized on blood vessels, and is a key component of the pia and arachnoid membranes surrounding the brain."]}]}
{"type": "biolink:Cell", "ic": "89.347505587204751", "identifiers": [{"i": "CL:0000612", "l": "eosinophilic myelocyte", "d": ["A eosinophil precursor in the granulocytic series, being a cell intermediate in development between a promyelocyte and a metamyelocyte;in this stage, production of primary granules is complete and eosinophil-specific granules has started. No nucleolus is present. These cells are integrin alpha-M-positive, CD13-positive, CD15-positive, CD16-negative, CD24-positive, and CD33-positive."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5174092", "l": "Myeloblasts | Blood | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5688428", "l": "Population of all cells positive for progesterone receptor in portion of fluid", "d": []}, {"i": "SNOMEDCT:1222876002", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157451", "l": "CD3+CD56+ cells | Tissue and Smears | Cell markers", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1545461", "l": "Cells.CD11c+CD19+", "d": []}]}
{"type": "biolink:Cell", "ic": "92.728541327098611", "identifiers": [{"i": "CL:0000963", "l": "Bm3-delta B cell", "d": ["A germinal center B cell that develops from a Bm3 B cell. This cell has the phenotype IgM-negative, IgD-positive, and CD38-positive."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1181725", "l": "Type II cell of adrenal cortex", "d": []}]}
{"type": "biolink:Cell", "ic": "86.236661114203869", "identifiers": [{"i": "UMLS:C1517536", "l": "Geron ES Cell Line", "d": []}, {"i": "NCIT:C20255", "l": "Geron ES Cell Line", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5174618", "l": "Neutrophils | Fetus | Pleural fluid | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1267936", "l": "Lymphocyte positive for CD49A antigen", "d": []}, {"i": "SNOMEDCT:117379004", "d": []}]}
{"type": "biolink:Cell", "ic": "71.079643100360357", "identifiers": [{"i": "UMLS:C1518180", "l": "Malignant Epithelioid Cell", "d": []}, {"i": "NCIT:C41435", "l": "Malignant Epithelioid Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C0282639", "l": "HT29 Cells", "d": []}, {"i": "NCIT:C17896", "l": "HT29", "d": ["An adenocarcinoma cell line established from a 44 year old Caucasian female patient with colon carcinoma."]}, {"i": "MESH:D019073", "l": "HT29 Cells", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5575126", "l": "Cilta-cel", "d": []}]}
{"type": "biolink:Cell", "ic": "84.75972595860604", "identifiers": [{"i": "CL:1000413", "l": "endothelial cell of artery", "d": ["A blood vessel endothelial cell that is part of an arterial endothelium."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4038460", "l": "Non-hematopoietic stem cell", "d": []}, {"i": "SNOMEDCT:725272001", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5158561", "l": "Cells.CD4-CD8-CD45R+TCR alpha beta+ | Blood | Cell markers", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5163454", "l": "Eosinophils/100 cells | Bone marrow | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "ic": "89.347505587204751", "identifiers": [{"i": "CL:0002058", "l": "Gr1-low non-classical monocyte", "d": ["A resident monocyte that is Gr-1 low, CD43-positive, and CX3CR1-positive."]}]}
{"type": "biolink:Cell", "ic": "76.281523396999802", "identifiers": [{"i": "UMLS:C0019612", "l": "Histiocytes", "d": []}, {"i": "NCIT:C12563", "l": "Histiocyte", "d": ["A macrophage present in connective tissue."]}, {"i": "MESH:D006644", "l": "Histiocytes", "d": []}, {"i": "SNOMEDCT:14295007", "d": []}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "CL:0001050", "l": "effector CD8-positive, alpha-beta T cell", "d": ["A CD8-positive, alpha-beta T cell with the phenotype CCR7-negative, CD45RA-positive."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1179870", "l": "Nodal myocyte", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002157", "l": "endosteal cell", "d": ["A cell type that makes up the highly vascular membrane lining the marrow cavity of long bones."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0933804", "l": "Type B synoviocyte", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5382908", "l": "HLA-B8 CMV specific CD8 cells | Blood | Cell markers", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5687323", "l": "Population of all neutrophilic myelocytes in portion of fluid", "d": []}, {"i": "SNOMEDCT:1208769003", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2350248", "l": "Hemangioblasts", "d": []}, {"i": "MESH:D055018", "l": "Hemangioblasts", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1518169", "l": "Malignant Clear Cell Oncocyte", "d": []}, {"i": "NCIT:C36940", "l": "Malignant Clear Cell Oncocyte", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0008015", "l": "inhibitory motor neuron", "d": ["A motor neuron that is capable of directly inhibiting muscle contraction."]}]}
{"type": "biolink:Cell", "ic": "70.216808612803263", "identifiers": [{"i": "CL:0002368", "l": "respiratory epithelial cell", "d": ["An endo-epithelial cell of the respiratory tract."]}]}
{"type": "biolink:Cell", "ic": "80.511444690059548", "identifiers": [{"i": "CL:0000059", "l": "ameloblast", "d": ["Skeletogenic cell that produces enamel, overlies the odontogenic papilla, and arises from the differentiation of a preameloblast cell."]}]}
{"type": "biolink:Cell", "ic": "88.140761698499901", "identifiers": [{"i": "CL:4023036", "l": "chandelier pvalb GABAergic cortical interneuron", "d": ["A pvalb GABAergic cortical interneuron that is recognizable by the straight terminal axonal 'cartridges' of vertically oriented strings of synaptic boutons. Chandelier PV cells' boutons target exclusively the axon initial segment (AIS) of pyramidal cells, with a single cell innervating hundreds of pyramidal cells in a clustered manner."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2362027", "l": "Frozen erythrocytes", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C0227276", "l": "Paneth Cells", "d": []}, {"i": "NCIT:C12593", "l": "Paneth Cell", "d": ["A granule-rich columnar epithelial cell found in the mucous membrane lining at the base of the small intestine crypts of Lieberkühn. Paneth Cells secrete antimicrobial peptides that contribute to microbial density in the lumen of the small intestine and in the maintenance of the gastrointestinal barrier."]}, {"i": "MESH:D019879", "l": "Paneth Cells", "d": []}, {"i": "SNOMEDCT:84907006", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5556651", "l": "Autologous Memory Cytokine-enriched Natural Killer Cells", "d": []}, {"i": "NCIT:C180827", "l": "Autologous Memory Cytokine-enriched Natural Killer Cells", "d": ["A population of cryopreserved, autologous CD56-positive memory cytokine-enriched natural killer (NK) cells (m-ceNKs), armed with NK cell-activating surface receptors, with potential immunomodulating and antitumor activities. Autologous NK cells are pre-activated ex vivo with a cytokine cocktail, which induces the differentiation of the NK cells into immune-memory m-ceNKs, which possess a unique phenotype. The pretreated NKs exhibit enhanced cytotoxicity and increased interferon-gamma (IFN-g) production. Upon administration, the autologous m-ceNKs may recognize and kill tumor cells."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C0022891", "l": "Labyrinth Supporting Cells", "d": []}, {"i": "NCIT:C12590", "l": "Supporting Cell of Organ of Corti", "d": ["One of the non-sensory cells that compose the supporting structures of the Organ of Corti."]}, {"i": "NCIT:C33240", "l": "Outer Supporting Cell", "d": ["A cell forming a cup for the outer hair cell of the Organ of Corti. The supporting cell sends out a narrow filament that angles towards the base of the cochlea. The structure is such that the supporting cell touches the outer hair cell only at the top and bottom."]}, {"i": "MESH:D007760", "l": "Labyrinth Supporting Cells", "d": []}, {"i": "SNOMEDCT:28199004", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1267828", "l": "T lymphocyte positive for both CD8 antigen and CD11b antigen", "d": []}, {"i": "SNOMEDCT:115414002", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1267835", "l": "Lymphocyte positive for both CD3 antigen and HLA-DR antigen", "d": []}, {"i": "SNOMEDCT:117525009", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C4727342", "l": "Tumor-Infiltrating Immune Cell", "d": []}, {"i": "NCIT:C153548", "l": "Tumor-Infiltrating Immune Cell", "d": ["Immune cells that have left the bloodstream and migrated into a tumor."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1524008", "l": "Leukocyte - Natural Killer Cell (MMHCC)", "d": []}, {"i": "NCIT:C22595", "l": "Mouse Natural Killer Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0000348", "l": "choroidal cell of the eye", "d": ["A structural cell that is part of optic choroid."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1440346", "l": "Cells.CD66d", "d": []}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "UMLS:C1510753", "l": "Acantholytic Keratinocyte", "d": []}, {"i": "NCIT:C36747", "l": "Acantholytic Keratinocyte", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0000956", "l": "pre-B-I cell", "d": ["A pre-B-I cell is a precursor B cell that expresses CD34 and surrogate immunoglobulin light chain (VpreB , Lambda 5 (mouse)/14.1 (human)) on the cell surface, and TdT, Rag1,and Rag2 intracellularly. Cell type carries a D-JH DNA rearrangement, and lacks expression of immunglobulin heavy chain protein."]}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "UMLS:C1517690", "l": "LH Cells", "d": []}, {"i": "NCIT:C32985", "l": "LH Cell", "d": ["A luteinizing hormone secreting cell found in the anterior pituitary gland."]}]}
{"type": "biolink:Cell", "ic": "48.065249845599688", "identifiers": [{"i": "CL:0000680", "l": "muscle precursor cell", "d": ["A non-terminally differentiated cell that is capable of developing into a muscle cell."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5417828", "l": "Autologous 1928T2z CAR T-cells WZTL-002", "d": []}, {"i": "NCIT:C170905", "l": "Autologous 1928T2z CAR T-cells WZTL-002", "d": ["A preparation of autologous, third-generation T-lymphocytes that have been transduced with a self-inactivating lentiviral vector to express a chimeric antigen receptor (CAR) containing a single-chain variable fragment (scFv) from the monoclonal antibody FMC63, which is directed against the CD19 antigen, and linked to the co-stimulatory intracellular signaling domains of CD28 and the zeta chain of the TCR/CD3 complex (CD3-zeta) (CD28zeta; CD28z), and the Toll/interleukin-1 receptor (TIR) domain from Toll-like receptor 2 (TLR2) as an additional co-stimulatory domain, with potential immunostimulating and antineoplastic activities. Upon administration, the autologous 1928T2z CAR T-cells WZTL-002 specifically recognize and bind to CD19-expressing tumor cells, resulting in specific T-cell-mediated tumor cell lysis. CD19 antigen is a B-cell specific cell surface antigen, which is expressed in all B-cell lineage malignancies and normal B-cells. In addition to CD28 and CD3zeta, the TLR2-TIR domain provides co-stimulatory activity and may enhance the cytotoxic effect and anti-tumor activity of the CAR T-cells. The TIR domain from TLR2 mediates the intracellular signaling of TLR2; TLR2 stimulation enhances T-cell activation, proliferation and cytokine production."]}]}
{"type": "biolink:Cell", "ic": "84.75972595860604", "identifiers": [{"i": "CL:0002165", "l": "phalangeal cell", "d": ["A supporting cell that is attached to the basement membrane and forms rows that support the hair cells."]}]}
{"type": "biolink:Cell", "ic": "75.26123597683771", "identifiers": [{"i": "UMLS:C1514102", "l": "Neoplastic Stellate Cell", "d": []}, {"i": "NCIT:C36899", "l": "Neoplastic Stellate Cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4531900", "l": "Plasma cells.monotypic population", "d": []}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "UMLS:C1512564", "l": "Hypogranular Promyelocyte", "d": []}, {"i": "NCIT:C37074", "l": "Hypogranular Promyelocyte", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4510904", "l": "Blast cell positive for CD179a antigen", "d": []}, {"i": "SNOMEDCT:724249006", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0009059", "l": "plasma cell of medullary sinus of lymph node", "d": ["A plasma cell that is located in the medullary sinus of the lymph node."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0229606", "l": "Reticulum cell", "d": []}, {"i": "SNOMEDCT:37510001", "d": []}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "CL:0002493", "l": "strial basal cell", "d": ["A polarized cell that is juxtaposed to fibrocytes in the underlying spiral ligament. This cell type secretes potassium ions derived from fibrocytes through gap junctions."]}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "CL:0002423", "l": "DN2a thymocyte", "d": ["A DN2 thymocyte that is Kit-hi."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0546504", "l": "P.B. hematohistioblast", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157275", "l": "CD11c-CD20+ cells | Blood | Cell markers", "d": []}]}
{"type": "biolink:Cell", "ic": "68.652206388559449", "identifiers": [{"i": "CL:0002374", "l": "ear hair cell", "d": ["A hair cell of the ear that contains the organs of balance and hearing."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1512085", "l": "Ductal Epithelial Cell", "d": []}, {"i": "NCIT:C12479", "l": "Ductal Epithelial Cell", "d": ["A stratified columnar epithelial cell that surrounds a lumen in a gland such as the breast, pancreas or prostate. These cells are uniform in appearance and have uniformly sized and shaped nuclei."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0228076", "l": "Primitive neuroblastic cell", "d": []}, {"i": "SNOMEDCT:20367003", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157309", "l": "CD14 blasts | XXX | Cell markers", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1257792", "l": "Vascular Endothelial Cells", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1514176", "l": "Pleomorphic Meningothelial Cell", "d": []}, {"i": "NCIT:C37158", "l": "Pleomorphic Meningothelial Cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0333793", "l": "Abnormal hematopoietic cell", "d": []}, {"i": "SNOMEDCT:107677004", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0333843", "l": "Myeloma cell", "d": []}, {"i": "SNOMEDCT:64446007", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1440265", "l": "Cells.CD19+CD23+", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4518159", "l": "Population of all progressive spermatozoa in portion of fluid", "d": []}, {"i": "SNOMEDCT:726585007", "d": []}]}
{"type": "biolink:Cell", "ic": "87.120474278337809", "identifiers": [{"i": "CL:1000296", "l": "epithelial cell of urethra", "d": ["An epithelial cell that is part of the urethra."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:1000373", "l": "transitional myocyte of ventricular part of atrioventricular bundle", "d": ["A transitional myocyte that is part of the ventricular part of atrioventricular bundle."]}]}
{"type": "biolink:Cell", "ic": "72.269651791985453", "identifiers": [{"i": "UMLS:C1879552", "l": "Adenocarcinoma Cell with Abundant Cytoplasm", "d": []}, {"i": "NCIT:C60433", "l": "Adenocarcinoma Cell with Abundant Cytoplasm", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5184821", "l": "Variant lymphocytes | Fetus | Blood | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "ic": "87.120474278337809", "identifiers": [{"i": "CL:0002638", "l": "bronchioalveolar stem cell", "d": ["A respiratory stem cell found at the junction of the terminal (conductive) bronchiole and the respiratory bronchiole. This cell types gives rise to alveolar cell types and club cells in response to lung injury. This cell type expresses markers Scgb1a1 and Sftpc."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2323029", "l": "Mesothelial cell of dura mater", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0221279", "l": "Burr cell", "d": []}, {"i": "SNOMEDCT:51384001", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:2000018", "l": "endothelial cell of coronary artery", "d": ["Any endothelial cell of artery that is part of a coronary artery."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002021", "l": "GlyA-positive erythrocyte", "d": ["An enucleate erythrocyte that is GlyA-positive."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:4030012", "l": "kidney loop of Henle short descending thin limb epithelial cell", "d": ["Epithelial cell of the descending thin limb of the short loop (cortical) nephron limited to the outer medulla (mainly inner strip). It is known in some mammalian species that the short descending limb of the loop of Henle selectively expresses the serine protease Corin, the homeobox TF Uncx, and the urea channel Slc14a2."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C3826976", "l": "IL-12-expressing Mesenchymal Stem Cell Vaccine GX-051", "d": []}, {"i": "NCIT:C114385", "l": "IL-12-expressing Mesenchymal Stem Cell Vaccine GX-051", "d": ["Human mesenchymal stem cells (MSCs) transduced with a retroviral vector encoding a modified form of the cytokine interleukin-12 (IL-12), with potential immunomodulating and antineoplastic activities. Upon intratumoral administration, IL-12-expressing MSC vaccine GX-051 secretes IL-12. IL-12 activates the immune system by both promoting the secretion of interferon-gamma, which activates natural killer cells (NKs), and inducing cytotoxic T-cell responses, which may result in both decreased cell proliferation and increased cell death in tumor cells."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002645", "l": "endo-epithelial cell of pharyngotympanic part of viscerocranial mucosa", "d": ["An endocranial viscerocranial mucosa cell that is part of viscerocranial mucosa."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157631", "l": "CD61 cells | Blood | Cell markers", "d": []}]}
{"type": "biolink:Cell", "ic": "82.076046914303362", "identifiers": [{"i": "UMLS:C1706828", "l": "Apocrine Cell", "d": []}, {"i": "NCIT:C43374", "l": "Apocrine Cell", "d": ["A glandular secreting cell in which the apical portion of the secreting cell is cast off along with the secretory products that have accumulated therein."]}]}
{"type": "biolink:Cell", "ic": "80.511444690059548", "identifiers": [{"i": "CL:0002598", "l": "bronchial smooth muscle cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5221142", "l": "Eosinophils|NCnc|Pt|Bld", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0000480", "l": "secretin stimulating hormone secreting cell", "d": ["A peptide hormone secreting cell that secretes secretin stimulating hormone"]}]}
{"type": "biolink:Cell", "ic": "84.128890093485552", "identifiers": [{"i": "CL:0002097", "l": "cortical cell of adrenal gland", "d": ["A cell of the adrenal cortex. Cell types include those that synthesize and secrete chemical derivatives (steroids) of cholesterol."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1440280", "l": "Cells.CD3+CD38+", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5557580", "l": "AloCelyvir", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157574", "l": "CD45 (Lymphs) cells | Blood | Cell markers", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1267927", "l": "Lymphocyte positive for CD44R antigen", "d": []}, {"i": "SNOMEDCT:117371001", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0312737", "l": "Immunologic cell", "d": []}, {"i": "SNOMEDCT:64419002", "d": []}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "CL:0005002", "l": "xanthoblast", "d": ["A non-terminally differentiated cell that differentiates into a xanthophore."]}]}
{"type": "biolink:Cell", "ic": "92.728541327098611", "identifiers": [{"i": "CL:0000434", "l": "eccrine cell", "d": ["A secretory cell that discharges its product without loss of cytoplasm."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5417934", "l": "Allogeneic CRISPR-Cas9 Engineered Anti-BCMA T Cells CTX120", "d": []}, {"i": "NCIT:C172741", "l": "Allogeneic CRISPR-Cas9 Engineered Anti-BCMA T Cells CTX120", "d": ["A preparation of human allogeneic T-lymphocytes gene-edited with the clustered regularly interspaced short palindromic repeats (CRISPR)-Cas9 nuclease complex to disrupt expression of endogenous TCR and major histocompatibility complex (MHC) class I molecules and modified to express a chimeric antigen receptor (CAR) specific for the tumor-associated antigen (TAA) human B-cell maturation antigen (BCMA; tumor necrosis factor receptor superfamily member 17; TNFRSF17), with potential immunostimulating and antineoplastic activities. Upon introduction into the patient, the allogeneic CRISPR-Cas9 engineered anti-BCMA CAR T-cells CTX120 recognize and bind to BCMA-overexpressing tumor cells. This may result in a specific cytotoxic T-lymphocyte (CTL)-mediated killing of BCMA-positive tumor cells. BCMA, a receptor for proliferation-inducing ligand (APRIL) and B-cell activating factor (BAFF), is a member of the tumor necrosis factor (TNF) receptor superfamily (TNFRSF) and plays a key role in plasma cell survival. BCMA is found on the surfaces of plasma cells and overexpressed on malignant plasma cells. The disruption of endogenous TCR prevents graft-versus-host disease (GvHD). The disruption of MHC class I molecules increases the persistence of the CAR T-cells."]}]}
{"type": "biolink:Cell", "ic": "92.728541327098611", "identifiers": [{"i": "UMLS:C1708645", "l": "Large Multinucleated Malignant Histiocyte", "d": []}, {"i": "NCIT:C43256", "l": "Large Multinucleated Malignant Histiocyte", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4322670", "l": "CD3+ T lymphocyte", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5446633", "l": "Autologous Alpha-PNE Switchable CAR-T Cells CLBR001", "d": []}, {"i": "NCIT:C175578", "l": "Autologous Alpha-PNE Switchable CAR-T Cells CLBR001", "d": ["A preparation of autologous T-lymphocytes that has been genetically engineered to express a switchable, alpha-peptide neo-epitope (PNE) chimeric antigen receptor (CAR) with a binding domain that can recognize a 14 aa peptide epitope, or PNE, of an antigen-specific adapter molecule, with potential immunomodulating and antineoplastic activities. Upon administration, autologous alpha-PNE switchable CAR-T (sCAR-T) cells CLBR001 remain inactivated. Upon administration of an antigen-specific adapter molecule, the binding domain of CLBR001 binds to the PNE of the adapter molecule, and CLBR001 is activated. This induces selective toxicity in and causes lysis of tumor cells expressing the specific antigen."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4300379", "l": "Erythrocytes.Babesia sp infected", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002207", "l": "brush cell of trachea", "d": ["Brush cell of the epithelium in the trachea."]}]}
{"type": "biolink:Cell", "ic": "80.869303025598512", "identifiers": [{"i": "CL:0000216", "l": "Sertoli cell", "d": ["A supporting cell projecting inward from the basement membrane of seminiferous tubules. They surround and nourish the developing male germ cells and secrete androgen binding protein. Their tight junctions with the spermatogonia and spermatocytes provide a blood-testis barrier."]}]}
{"type": "biolink:Cell", "ic": "84.128890093485552", "identifiers": [{"i": "CL:0002495", "l": "fetal cardiomyocyte", "d": ["A fetal and neonatal heart cell that undergoes proliferation and is not yet terminally differentiated into a binucleate or a multinucleate cardiac myocyte."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1267810", "l": "Lymphocyte positive for CD1 antigen", "d": []}, {"i": "SNOMEDCT:116850005", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0000986", "l": "IgM plasma cell", "d": ["A fully differentiated plasma cell that secretes IgM."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1831778", "l": "Viagenpumatucel-L", "d": []}, {"i": "NCIT:C61073", "l": "Viagenpumatucel-L", "d": ["A proprietary, allogeneic tumor cell vaccine expressing a recombinant secretory form of the heat shock protein gp96 fusion (gp96-Ig) with potential antineoplastic activity. Upon administration of viagenpumatucel-L, the irradiated live tumor cells continuously secrete gp96-Ig along with its chaperoned tumor associated antigens (TAAs) into the blood stream, thereby activating antigen presenting cells, natural killer cells and priming potent cytotoxic T lymphocytes (CTLs) to respond against TAAs on the endogenous tumor cells. Furthermore, this vaccine may induce long-lived memory T cells that could fight recurring cancer cells. gp96-Ig is constructed by replacing the KDEL retention sequence of gp96, normally an endoplasmatic reticulum-resident chaperone peptide, with the Fc portion of mouse and human IgG1."]}]}
{"type": "biolink:Cell", "ic": "83.023198044254755", "identifiers": [{"i": "UMLS:C1513493", "l": "Mott Cell", "d": []}, {"i": "NCIT:C37079", "l": "Mott Cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0815001", "l": "neuron by chemical response", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0009108", "l": "lymphatic endothelial cell of subcapsular sinus floor", "d": ["A lymphatic endothelial cell located in the subcapsular sinus floor of a lymph node. In human, it's characterized by a unique marker expression (TNFRSF9+)."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4322673", "l": "CD8+HLA-DR+ T lymphocyte", "d": []}]}
{"type": "biolink:Cell", "ic": "89.347505587204751", "identifiers": [{"i": "CL:0000001", "l": "primary cultured cell", "d": ["A cultured cell that is freshly isolated from a organismal source, or derives in culture from such a cell prior to the culture being passaged."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:1000361", "l": "transitional myocyte of interatrial septum", "d": ["A transitional myocyte that is part of the interatrial septum."]}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "CL:0017003", "l": "epithelial cell of prostatic urethra", "d": ["An epithelial cell that is part of the prostatic urethra."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C4053520", "l": "Interferon Beta-secreting Mesenchymal Stem Cells", "d": []}, {"i": "NCIT:C123724", "l": "Interferon Beta-secreting Mesenchymal Stem Cells", "d": ["Human autologous mesenchymal stem cells (MSCs) harvested from the bone marrow of healthy individuals and transduced with a retroviral vector encoding the human cytokine interferon beta (IFNb), with potential immunomodulating and antineoplastic activities. Upon administration of IFNb-secreting MSCs, the cells are attracted and specifically migrate to tumor sites and become part of the tumor microenvironment. Since the MSCs express IFNb, these cells selectively deliver high levels of IFNb to the tumor site. In turn, IFNb binds to IFN-specific cell surface receptors and modulates the transcription and translation of certain genes whose protein products are involved in tumor cell proliferation. This decreases tumor cell growth."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157453", "l": "CD3+CD62L+ cells | Blood | Cell markers", "d": []}]}
{"type": "biolink:Cell", "ic": "88.140761698499901", "identifiers": [{"i": "UMLS:C1881551", "l": "Malignant Epithelial Oval Cell", "d": []}, {"i": "NCIT:C60991", "l": "Malignant Epithelial Oval Cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0282479", "l": "Muscle Fibers, Red", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:1000433", "l": "epithelial cell of lacrimal canaliculus", "d": ["An epithelial cell that is part of the lacrimal canaliculus."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5770478", "l": "ICG-140", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4267784", "l": "Cells.CD38+HLA-DR+", "d": []}]}
{"type": "biolink:Cell", "ic": "44.023560223154647", "identifiers": [{"i": "UMLS:C1709186", "l": "Neoplastic Mononuclear Stromal Cell", "d": []}, {"i": "NCIT:C49055", "l": "Neoplastic Mononuclear Stromal Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1517640", "l": "KA40 cell line", "d": []}, {"i": "NCIT:C20270", "l": "KA40", "d": ["Provider: Karolinska Institute, Stockholm, Sweden. No information from provider. This cell line meets the criteria for the use of human embryonic stem cells by federally funded researchers."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4300401", "l": "Cells.chromosome region 7q31", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2338668", "l": "Microfold cell of epithelium of small intestine", "d": []}]}
{"type": "biolink:Cell", "ic": "77.271239091128209", "identifiers": [{"i": "CL:0000306", "l": "crystallin accumulating cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1254949", "l": "Nk Lymphocyte", "d": []}]}
{"type": "biolink:Cell", "ic": "90.82444074280258", "identifiers": [{"i": "CL:0000922", "l": "type II NK T cell", "d": ["An alpha-beta T cell expressing NK call markers that is CD1d restricted and expresses a diverse TCR repertoire. Type II NKT cells do not become activated by alpha-galactosylceramide when presented by CD1d."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C4763592", "l": "Autologous CD34-positive BCL11A-disrupted Hematopoietic Progenitor Cells BIVV003", "d": []}, {"i": "NCIT:C157393", "l": "Autologous CD34-positive BCL11A-disrupted Hematopoietic Progenitor Cells BIVV003", "d": ["A population of autologous cluster of differentiation 34 (CD34)-positive hematopoietic progenitor cells (HPCs) that are transfected ex vivo with zinc finger nuclease (ZFN) messenger ribonucleic acid (mRNA) targeting the B-cell lymphoma/leukemia 11A (BCL11A) locus, with potential usage for transplantation in patients with sickle cell disease (SCD). CD34-positive HPCs are isolated from human blood upon apheresis and are genetically modified in vitro using ZFN technology to specifically cleave and disrupt the erythroid enhancer of the BCL11A gene. This suppresses the production of sickle hemoglobin. Upon infusion into the patient following conditioning chemotherapy, the autologous CD34-positive BCL11A-disrupted HPCs BIVV003 can populate the bone marrow and differentiate into a variety of blood cell types including lymphoid cells, myeloid cells and erythroblasts. As BCL11A is a suppressor of fetal hemoglobin (HbF) expression, disruption of the BCL11A enhancer decreases the expression of BCL11A and stimulates the expression of HbF in erythrocytes that differentiate from BIVV003. HbF may compensate for reduced or absent expression of adult hemoglobin in patients with SCD."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002130", "l": "regular interatrial cardiac myocyte", "d": ["A cardiac myocyte of the interatrial region of the heart."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2350243", "l": "Granulocyte-Macrophage Progenitor Cells", "d": []}, {"i": "MESH:D055014", "l": "Granulocyte-Macrophage Progenitor Cells", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5427285", "l": "Nucleated cells | Sputum | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "ic": "73.239986017158159", "identifiers": [{"i": "CL:0000172", "l": "somatostatin secreting cell", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1519376", "l": "Small Lymphocyte-Like Neoplastic Germ Cell", "d": []}, {"i": "NCIT:C37131", "l": "Small Lymphocyte-Like Neoplastic Germ Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "UMLS:C3146292", "l": "Mouse Basophil", "d": []}, {"i": "NCIT:C22591", "l": "Mouse Basophil", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0003008", "l": "G5 retinal ganglion cell", "d": ["A mono-stratified retinal ganglion cell that has a medium dendritic field and a medium dendritic arbor with post sympatic terminals in sublaminar layer S2."]}]}
{"type": "biolink:Cell", "ic": "63.119211224969447", "identifiers": [{"i": "CL:0000130", "l": "neuron associated cell (sensu Nematoda and Protostomia)", "d": []}]}
{"type": "biolink:Cell", "ic": "64.483855464319362", "identifiers": [{"i": "CL:0000630", "l": "supporting cell", "d": ["A cell whose primary function is to support other cell types."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5707893", "l": "Lecilimogene Autotemcel", "d": []}, {"i": "NCIT:C188589", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1522105", "l": "Mouse Pre-B-Lymphocyte", "d": []}, {"i": "NCIT:C22574", "l": "Mouse Pre-B-Lymphocyte", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0229611", "l": "Tissue neutrophil", "d": []}, {"i": "SNOMEDCT:88397004", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5432253", "l": "Descartes-30", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1268458", "l": "Cell positive for CD43 antigen", "d": []}, {"i": "SNOMEDCT:116833008", "d": []}]}
{"type": "biolink:Cell", "ic": "76.281523396999802", "identifiers": [{"i": "UMLS:C1709203", "l": "Neoplastic Spindle-Shaped Fibrohistiocytic Cell", "d": []}, {"i": "NCIT:C49075", "l": "Neoplastic Spindle-Shaped Fibrohistiocytic Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "85.457082654197222", "identifiers": [{"i": "CL:0002054", "l": "fraction E immature B cell", "d": ["An immature B cell that is IgM-positive, CD45R-positive, CD43-low, CD25-negative, and CD127-negative. This cell type has also been described as being AA4-positive, IgM-positive, CD19-positive, CD43-low/negative, and HSA-positive."]}]}
{"type": "biolink:Cell", "ic": "88.140761698499901", "identifiers": [{"i": "CL:0000042", "l": "neutrophilic myeloblast", "d": ["A myeloblast committed to the neutrophil lineage. This cell type is GATA-1 positive, C/EBPa-positive, AML-1-positive, c-myb-positive and has low expression of PU.1 transcription factor."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0933801", "l": "Glandular columnar cell", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5707294", "l": "Autologous CXCR2-modified CD70 CAR T-cells", "d": []}, {"i": "NCIT:C187688", "l": "Autologous CXCR2-modified CD70 CAR T-cells", "d": ["A preparation composed of ex-vivo expanded CXC chemokine receptor 2 (CXCR2) modified patient-derived activated CD70 (CD27 ligand; tumor necrosis factor superfamily member 7; TNFSF7) chimeric antigen receptor (CAR) (8R-70CAR) T-cells, with potential immunostimulating and antineoplastic activities. Upon administration of the autologous CXCR2-modified CD70 CAR T-cells, the anti-CD70-CARs on the T-cell surfaces target and bind to the CD70 antigen on tumor cell surfaces. This induces a cytotoxic T-lymphocyte (CTL)-mediated immune response against CD70-expressing tumor cells. CD70, a cytokine belonging to the tumor necrosis factor superfamily (TNFSF) and the ligand for the costimulatory receptor CD27, is expressed on the surfaces of various types of cancer cells; its overexpression may play an important role in the evasion of immune surveillance. CXCR2, a transmembrane protein also known as interleukin (IL)-8 receptor B (IL-8RB), plays a key role in inflammation and cancer progression. Certain CXCR2 ligands, such as CXCL1 and CXCL8 (IL-8), are expressed by tumor cells. CXCR2-modified CARs enhance intratumoral T-cell trafficking toward tumor cells and promotes persistence of T-cells. This may enhance the T-cell-mediated immune response against the CD70-expressing tumor cells."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0221280", "l": "Elliptocyte (cell)", "d": []}, {"i": "SNOMEDCT:45028007", "d": []}, {"i": "SNOMEDCT:57882002", "d": []}, {"i": "SNOMEDCT:739028009", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:4033016", "l": "secondary crest myofibroblast", "d": ["A myofibroblast that is part of an alveoli during alveolarization. The contractile force of this cell elongates the secondary crest, while producing a framework of elastin and tenascin. During the maturation of the septa, secondary crest myofibroblasts, together with matrix fibroblasts, secrete metalloproteinases and other ECM‐remodeling proteins to thin the septal tip ECM. The secondary crest myofibroblast continues producing elastin, eventually undergoing apoptosis during adulthood."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0546493", "l": "P.B. eosinophilic myelocyte", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157422", "l": "CD3 blasts | XXX | Cell markers", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1512131", "l": "ES02", "d": []}, {"i": "NCIT:C20250", "l": "ES02", "d": ["Provider: ES Cell International Pte Ltd., Melbourne, Australia. Information from provider and not independently verified by NIH: Cells are positive for cell markers Oct-4, SSEA-4, TRA-1-60, GCTM-2, and alkaline phosphatase activity; Cells are negative for cell marker SSEA-1; Give rise to teratomas containing derivatives of three germ layers in SCID mice; Differentiate in vitro into extraembryonic and somatic cell lineages; Neural progenitor cells may be isolated from differentiating ES cell cultures and induced to form mature neurons; Available for distribution. This cell line meets the criteria for the use of human embryonic stem cells by federally funded researchers."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1267913", "l": "Lymphocyte positive for CD36 antigen", "d": []}, {"i": "SNOMEDCT:117582005", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:1001214", "l": "arcuate artery smooth muscle cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1440279", "l": "Cells.CD3+CD16+", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5184400", "l": "Unidentified cells | Pleural fluid | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C4085963", "l": "Anti-CD22 scFv TCRz:41BB-CAR Lentiviral Vector-transduced Autologous T-lymphocytes", "d": []}, {"i": "NCIT:C124656", "l": "Anti-CD22 scFv TCRz:41BB-CAR Lentiviral Vector-transduced Autologous T-lymphocytes", "d": ["Autologous human T-lymphocytes transduced with a recombinant lentiviral vector encoding a chimeric T-cell receptor consisting of an anti-CD22 single chain variable fragment (scFv) and the co-stimulatory domain 4-1BB (CD137) coupled to the zeta chain of the TCR/CD3 complex (CD3-zeta), with potential immunostimulating and antineoplastic activities. Autologous peripheral blood lymphocytes (PBLs) from a patient with CD22-positive cancer are transduced with this lentiviral vector that encodes the CAR gene specific for CD22. After isolation, transduction, expansion in culture and reintroduction into the patient, the anti-CD22 scFv TCRz:41BB-CAR lentiviral vector-transduced autologous T-lymphocytes express anti-CD22-CAR on their cell surfaces and bind to the CD22 antigen on tumor cell surfaces. Subsequently, CD22-expressing tumor cells are lysed. CD22, a B-lineage-restricted, transmembrane phosphoglycoprotein, is expressed on malignant B-cells."]}]}
{"type": "biolink:Cell", "ic": "90.82444074280258", "identifiers": [{"i": "CL:0000923", "l": "CD4-positive type I NK T cell", "d": ["A type I NK T cell that has the phenotype CD4-positive."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5382904", "l": "HLA-A1 CMV specific CD8 cells | Blood | Cell markers", "d": []}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "CL:0002081", "l": "type II cell of carotid body", "d": ["This cell resembles a glia cell, express the glial marker S100 and act as a supporting cell to type I cell. This cell is located in a small cluster of type I and type II cells near the fork of the carotid artery."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C4725931", "l": "Autologous Tumor-specific Antigen-loaded Dendritic Cells", "d": []}, {"i": "NCIT:C150697", "l": "Autologous Tumor-specific Antigen-loaded Dendritic Cells", "d": ["A cell-based cancer vaccine composed of autologous dendritic cells (DCs) loaded with tumor-specific antigen(s) (TSAs), with potential immunostimulatory and antineoplastic activities. Upon administration of the autologous TSA-loaded DCs, the DCs stimulate a specific cytotoxic T-lymphocyte (CTL)-mediated immune response against the tumor cells expressing the TSA(s), resulting in tumor cell lysis."]}]}
{"type": "biolink:Cell", "ic": "88.140761698499901", "identifiers": [{"i": "UMLS:C1956385", "l": "Plasmacytoid Dendritic Cells", "d": []}, {"i": "NCIT:C45236", "l": "Plasmacytoid Dendritic Cell", "d": ["A cell found in peripheral blood, lymphoid tissue, and some inflamed tissue. It produces vast amounts of type I interferons especially in response to viruses, therefore playing an important role in antiviral immunity and triggers for adaptive immune responses."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C0228090", "l": "Fibrillary astrocyte", "d": []}, {"i": "NCIT:C32600", "l": "Fibrous Astrocyte", "d": ["A neuroglial cell of ectodermic origin having long, thin, infrequently branched cytoplasmic processes containing numerous fibrillar structures. It is found mainly in the white matter of the brain."]}, {"i": "SNOMEDCT:70357005", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1440386", "l": "Cells.euploid+Cells.aneuploid.population 2", "d": []}]}
{"type": "biolink:Cell", "ic": "92.728541327098611", "identifiers": [{"i": "UMLS:C1710397", "l": "Thymic Epithelial Cell Capable of Differentiating Towards Both Cortical and Medullary Cell Type", "d": []}, {"i": "NCIT:C45704", "l": "Thymic Epithelial Cell Capable of Differentiating Towards Both Cortical and Medullary Cell Type", "d": ["A reticular epithelial cell generated in the thymus that, in optimal conditions, can become either a cortex type of thymus cell that mediates positive selection or a medullary type of thymus cell that mediates negative selection of developing thymocytes."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0682551", "l": "Argyrophilic cell", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0000699", "l": "paraganglial type 1 cell", "d": ["A type of glomus or chief cell, is sensitive to hypoxia and produce catecholamines."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5571851", "l": "100 Erythroblasts", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2736929", "l": "Cells.CD19+CD20+", "d": []}]}
{"type": "biolink:Cell", "ic": "80.17194633000733", "identifiers": [{"i": "CL:4023047", "l": "L2/3 intratelencephalic projecting glutamatergic neuron of the primary motor cortex", "d": ["An intratelencephalic-projecting glutamatergic neuron with a soma found in cortical layer 2/3 of the primary motor cortex."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5155172", "l": "Blasts | Synovial fluid | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5221013", "l": "Unidentified cells|NCnc|Pt|Synv fld", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5572423", "l": "Erythrocytes.ghost cells | Urine sediment | Urinalysis", "d": []}]}
{"type": "biolink:Cell", "ic": "72.473322228407739", "identifiers": [{"i": "UMLS:C1515275", "l": "Terminal Ductal Lobular Unit Cell", "d": []}, {"i": "NCIT:C33756", "l": "Terminal Ductal Lobular Unit Cell", "d": ["An epithelial cell found in the small lobes at the end of the milk ducts inside the breast where the milk-producing cells are."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4518160", "l": "Population of all large oval head spermatozoa in portion of fluid", "d": []}, {"i": "SNOMEDCT:725387008", "d": []}]}
{"type": "biolink:Cell", "ic": "92.728541327098611", "identifiers": [{"i": "CL:0002118", "l": "CD38-negative IgG-negative class switched memory B cell", "d": ["A CD38-negative IgG-negative memory B cell is a IgG-negative class switched memory B cell that lacks IgG on the cell surface with the phenotype CD38-negative and IgG-negative."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4510902", "l": "Blast cell positive for CD11a antigen", "d": []}, {"i": "SNOMEDCT:724244001", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C4726569", "l": "Autologous PD1-inhibiting Anti-CD19 4-1BB CAR T Cells", "d": []}, {"i": "NCIT:C151944", "l": "Autologous PD1-inhibiting Anti-CD19 4-1BB CAR T Cells", "d": ["A preparation of autologous T-lymphocytes that are transduced with a lentiviral vector encoding a chimeric antigen receptor (CAR) specific for the tumor-associated antigen (TAA) cluster of differentiation 19 (CD19) linked to the intracellular signaling domain of 4-1BB (CD137) that also encodes a cell-intrinsic programmed cell death 1 (PD1; PDCD1; CD279; programmed death-1) short/small hairpin RNA (shRNA)-expressing cassette, with potential immunomodulating and antineoplastic activities. Upon administration of the autologous PD1-inhibiting anti-CD19 4-1BB CAR T-cells, these cells target, bind to and induce selective toxicity in CD19-expressing tumor cells. CD19 antigen is a B-cell specific cell surface antigen expressed in all B-cell lineage malignancies. The shRNA silences expression of PD1, abrogates T-cell exhaustion, increases CAR T-cell activity and enhances tumor cytotoxicity. Expression of PD-1, an inhibitory receptor expressed on activated T-cells, plays a key role in CTL suppression, T-cell exhaustion and CTL apoptosis."]}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "UMLS:C1519907", "l": "Vacuolated Endothelial Cell", "d": []}, {"i": "NCIT:C37091", "l": "Vacuolated Endothelial Cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4316839", "l": "CD16-CD57+", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0017001", "l": "splanchnic mesodermal cell", "d": ["A mesodermal cell that is part of the splanchnic layer of lateral plate mesoderm."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0222678", "l": "Undifferentiated mesenchymal cell", "d": []}, {"i": "SNOMEDCT:75091002", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1518314", "l": "Nevus Cell C-Type", "d": []}, {"i": "NCIT:C36866", "l": "Nevus Cell C-Type", "d": []}]}
{"type": "biolink:Cell", "ic": "88.140761698499901", "identifiers": [{"i": "UMLS:C1514736", "l": "Reactive Epithelial Cell", "d": []}, {"i": "NCIT:C36809", "l": "Reactive Epithelial Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "CL:0003051", "l": "UV cone cell", "d": ["A cone cell that detects ultraviolet (UV) wavelength light."]}]}
{"type": "biolink:Cell", "ic": "89.347505587204751", "identifiers": [{"i": "CL:4023004", "l": "nuclear bag fiber", "d": ["A type of intrafusal muscle fiber that lies in the center of a muscle spindle. Nuclei are clustered centrally and give the equatorial region a swollen appearance. They are associated with associated with dynamic gamma motor neurons, and the stretching of the equatorial region of the nuclear bag fibers results in an increase in the firing rate of type Ia sensory fibers."]}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "UMLS:C1710442", "l": "Totipotent Primordial Germ Cell", "d": []}, {"i": "NCIT:C45734", "l": "Totipotent Primordial Germ Cell", "d": ["One of the earliest cells of an organism that will be able to reproduce that kind of organism. It is able to develop into any variety of germ cell."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C3496271", "l": "B9 serotonin cells", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0427566", "l": "Macrothrombocyte", "d": []}, {"i": "SNOMEDCT:134203001", "d": []}]}
{"type": "biolink:Cell", "ic": "70.441195081532641", "identifiers": [{"i": "UMLS:C1514055", "l": "Neoplastic Osteoblast", "d": []}, {"i": "NCIT:C36900", "l": "Neoplastic Osteoblast", "d": []}]}
{"type": "biolink:Cell", "ic": "79.849015605436421", "identifiers": [{"i": "UMLS:C0027950", "l": "neutrophil", "d": []}, {"i": "NCIT:C12533", "l": "Neutrophil", "d": ["Granular leukocytes having a nucleus with three to five lobes connected by slender threads of chromatin, and cytoplasm containing fine inconspicuous granules and stainable by neutral dyes."]}, {"i": "MESH:D009504", "l": "Neutrophils", "d": []}]}
{"type": "biolink:Cell", "ic": "78.695011174409487", "identifiers": [{"i": "CL:1000426", "l": "chromaffin cell of adrenal gland", "d": ["A chromaffin cell that is part of the adrenal gland."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0000932", "l": "type II NK T cell secreting interferon-gamma", "d": ["A type II NK T cell that has been recently activated, secretes interferon-gamma, and has the phenotype CD69-positive and downregulated NK markers."]}]}
{"type": "biolink:Cell", "ic": "68.537094497236609", "identifiers": [{"i": "CL:0000775", "l": "neutrophil", "d": ["Any of the immature or mature forms of a granular leukocyte that in its mature form has a nucleus with three to five lobes connected by slender threads of chromatin, and cytoplasm containing fine inconspicuous granules and stainable by neutral dyes."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C3641685", "l": "Anti-CD20-CAR-CD3zeta-4-1BB-expressing Autologous T-lymphocyte Cells", "d": []}, {"i": "NCIT:C104006", "l": "Anti-CD20-CAR-CD3zeta-4-1BB-expressing Autologous T-lymphocyte Cells", "d": ["A preparation of autologous blood T-lymphocytes that have been genetically modified to express a chimeric antigen receptor (CAR) consisting of an anti-CD20 scFv (single chain variable fragment); the cytoplasmic portion of the human TCR-[zeta] molecule; and the co-stimulatory molecule 4-1BB (CD137), with potential immunostimulating and antineoplastic activities. Upon transfusion, anti-CD20-CAR-CD3zeta-4-1BB-expressing autologous T-lymphocyte cells direct T-cells to CD20-expressing tumor cells. This results in cytotoxic T lymphocyte (CTL) and antibody responses against CD20-expressing tumor cells, causing tumor cell lysis. The CD20 antigen, a non-glycosylated cell surface phosphoprotein, is a B-cell specific cell surface antigen expressed in B-cell lineage malignancies. CD3 zeta is one of several membrane-bound polypeptides found in the T-cell receptor (TCR)/CD3 complex and regulates the assembly of complete TCR complexes and their expression on the cell surface. The 4-1BB co-stimulatory molecule signaling domain enhances activation and signaling after recognition of CD20; the inclusion of this signaling domain may increase the antitumor activity compared to the inclusion of the CD3-zeta chain alone."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5170451", "l": "Lambda lymphocytes | Blood | Cell markers", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:1000696", "l": "kidney interstitial inflammatory macrophage", "d": []}]}
{"type": "biolink:Cell", "ic": "81.648881485605159", "identifiers": [{"i": "CL:0000317", "l": "sebum secreting cell", "d": ["A cell secreting sebun, an oily substance secreted by sebaceous glands, composed of keratin, fat, and cellular debris."]}]}
{"type": "biolink:Cell", "ic": "88.140761698499901", "identifiers": [{"i": "CL:0000885", "l": "gut-associated lymphoid tissue macrophage", "d": ["A mucosa-associated lymphoid tissue macrophage found in the mucosa-associated lymphoid tissues of the gut."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1513469", "l": "Monocytoid B-Lymphocyte", "d": []}, {"i": "NCIT:C33138", "l": "Monocytoid B-Lymphocyte", "d": ["A lymphocyte derived most often from a pre-germinal center B cell, less often from a post-germinal center B cell. It is characterized by an abundant pale cytoplasm, indented nuclei with inconspicuous nucleoli, and open chromatin. It is found in the marginal zones of lymph nodes adjacent to the subcapsular and intermediary sinuses."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5220613", "l": "Spermatozoa|Urine/Urine sed", "d": []}]}
{"type": "biolink:Cell", "ic": "72.370703631459492", "identifiers": [{"i": "UMLS:C1711178", "l": "Bronchial Epithelial Cell", "d": []}, {"i": "NCIT:C54242", "l": "Bronchial Epithelial Cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0229646", "l": "Basophilic myelocyte", "d": []}, {"i": "SNOMEDCT:17295002", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1954880", "l": "Erythrocyte inclusion bodies", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4304487", "l": "Population of all smudge cells in portion of fluid", "d": []}, {"i": "SNOMEDCT:719701000", "d": []}]}
{"type": "biolink:Cell", "ic": "62.426889726972838", "identifiers": [{"i": "CL:0000080", "l": "circulating cell", "d": ["A cell which moves among different tissues of the body, via blood, lymph, or other medium."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2330982", "l": "Tanycytes", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:1000310", "l": "adipocyte of epicardial fat of right ventricle", "d": ["A fat cell that is part of the epicardial fat of right ventricle."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1267906", "l": "Lymphoblast positive for CD33 antigen", "d": []}, {"i": "SNOMEDCT:117577003", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C4055481", "l": "Akt-1/2 Inhibitor-treated Tumor Infiltrating Lymphocytes", "d": []}, {"i": "NCIT:C123720", "l": "Akt-1/2 Inhibitor-treated Tumor Infiltrating Lymphocytes", "d": ["Autologous tumor infiltrating lymphocytes (TILs) harvested directly from the infiltrate of a patient's tumor and treated with an inhibitor of the serine/threonine kinases Akt-1 and -2 (Akti-1/2) during ex vivo expansion, with potential antineoplastic activity. Upon reintroduction into the patient, the Akti-1/2-treated TILs recognize and kill cancer cells. Akt inhibition promotes the immunologic memory of the TILs and enhances their expansion, in vivo long-term persistence and antitumor activity."]}]}
{"type": "biolink:Cell", "ic": "68.312708028507217", "identifiers": [{"i": "CL:4023168", "l": "somatosensory neuron", "d": ["A neuron that is part of the somatic sensory system. Somatosensory neurons innervate the skin or integument to detect different types of thermal, chemical, and mechanical touch stimuli."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5175146", "l": "Nucleated cells | Body fluid | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "ic": "74.107231545810777", "identifiers": [{"i": "UMLS:C1513710", "l": "Mucin-Producing Neoplastic Epithelial Cell", "d": []}, {"i": "NCIT:C36891", "l": "Mucin-Producing Neoplastic Epithelial Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "68.949061832187297", "identifiers": [{"i": "CL:0001067", "l": "group 1 innate lymphoid cell", "d": ["An innate lymphoid cell that is capable of producing the type 1 cytokine IFN-gamma, but not Th2 or Th17 cell-associated cytokines."]}]}
{"type": "biolink:Cell", "ic": "69.78964318410506", "identifiers": [{"i": "CL:0000022", "l": "female germ line stem cell", "d": ["A stem cell that is the precursor of female gametes."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5382754", "l": "CD21lowCD38- cells | Blood | Cell markers", "d": []}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "CL:0002024", "l": "Kit-positive megakaryocyte progenitor cell", "d": ["A megakaryocyte progenitor cell that is Kit-positive, CD41-positive, CD9-positive, Sca-1-negative, IL7ralpha-negative, CD150-negative, and Fcgamma receptor II/III-low."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C4055424", "l": "Autologous NKG2D CAR-CD3zeta-DAP10-expressing T-Lymphocytes CYAD-01", "d": []}, {"i": "NCIT:C121536", "l": "Autologous NKG2D CAR-CD3zeta-DAP10-expressing T-Lymphocytes CYAD-01", "d": ["A preparation of autologous peripheral blood T-lymphocytes (PBTLs) that have been genetically modified and transduced with a retroviral vector to express a chimeric antigen receptor (CAR) encoding full-length human natural-killer group 2, member D receptor protein (NKG2D or KLRK1) fused to the CD3zeta cytoplasmic signaling domain and containing the naturally-expressed adaptor molecule DNAX-activating protein of 10 kDa (DAP10), with potential immunostimulating and antineoplastic activities. Upon infusion back into the patient, autologous NKG2D CAR-CD3zeta-DAP10-expressing T-lymphocytes CYAD-01 specifically recognize and bind to tumor cells expressing NKG2D ligands. This induces secretion of pro-inflammatory cytokines and results in the lysis of NKG2D ligand-expressing tumor cells. In addition, CYAD-01 targets, binds to and kills NKG2D ligand expressing tumor-associated endothelial cells in the neovasculature and immunosuppressive cells, such as regulatory T-cells (Tregs) and myeloid-derived suppressor cells (MDSCs) in the tumor microenvironment (TME) that express NKG2D ligands. It also activates macrophages within the TME. Ligands for NKG2D, such as MHC class I chain-related protein A (MICA), MICB, and members of the UL16-binding proteins (ULBP)/retinoic acid early transcript 1 (RAET1) family, are overexpressed on infected cells and most cancer cell types, but are not expressed on most normal, healthy cells. NKG2D, a dimeric, type II transmembrane protein expressed on human natural killer (NK) and certain T-cells, in association with the natural adaptive protein DAP10, promotes the elimination of NKG2D ligand-expressing cells. The CD3zeta signaling domain and DAP10 provide co-stimulatory signaling upon ligand binding, enhance the secretion of pro-inflammatory cytokines in response to binding to NKG2D ligand-expressing tumor cells and enhances T-cell cytotoxicity. DAP10 also associates with and stabilizes NKG2D, which facilitates expression of the NKG2D-CAR-CD3zeta construct at the cell surface."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5556546", "l": "Autologous CD19-CD8-CD28-CAR-mbIL15-HER1t T Cells", "d": []}, {"i": "NCIT:C180672", "l": "Autologous CD19-CD8-CD28-CAR-mbIL15-HER1t T Cells", "d": ["A preparation of autologous T-lymphocytes, that have been electroporated ex vivo with sleeping beauty (SB)-derived DNA plasmids encoding a chimeric antigen receptor (CAR) targeting the tumor-associated antigen (TAA) cluster of differentiation 19 (CD19) that is linked to the co-stimulatory molecules T-cell surface glycoproteins CD8 and CD28 and co-expressed with a chimeric membrane-bound fusion protein comprised of interleukin-15 (IL-15) fused to IL-15 receptor (mbIL15) and a safety/kill switch composed of a truncated form of the human epidermal growth factor receptor (ErbB1t; EGFR)(HER1t), with potential immunostimulating and antineoplastic activities. Upon reintroduction of the autologous CD19-CD8-CD28-CAR-mbIL15-HER1t T cells into the patient, the T-cells target and bind to CD19-expressing tumor cells, thereby inducing selective toxicity in CD19-expressing tumor cells. CD19 is a B-cell specific cell surface antigen overexpressed in all B-cell lineage malignancies.  HER1t can promote selective elimination of the CAR-T cells through cetuximab-induced antibody-dependent cellular cytotoxicity (ADCC) and complement-dependent cytotoxicity (CDC). IL-15 is a pro-survival cytokine that is required for the maintenance of long-lived CD8+ memory T-cells and the use of mbIL15 preserves T stem-cell memory (TSCM) through sustained IL-15 signaling, improves T-cell persistence and potentiates the immune response against tumor cells. The SB system permits electroporation of the CAR, the IL-15 fusion variant and safety switch transgenes into T-cells without the need for viral vectors and accelerates the manufacturing process."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0483181", "l": "CD10+CD20+", "d": []}]}
{"type": "biolink:Cell", "ic": "61.284682648756693", "identifiers": [{"i": "CL:0000030", "l": "glioblast", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5569915", "l": "Transitional cells.superficial", "d": []}]}
{"type": "biolink:Cell", "ic": "90.82444074280258", "identifiers": [{"i": "UMLS:C1711215", "l": "Bone Marrow Stem Cell Committed to the Basophil Lineage", "d": []}, {"i": "NCIT:C43227", "l": "Bone Marrow Stem Cell Committed to the Basophil Lineage", "d": ["A primitive, undifferentiated blood cell which can undergo division and will give rise to a cell in the basophil lineage."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002391", "l": "multinucleate blastoconidium", "d": ["A blastoconidium that has more than one nucleus."]}]}
{"type": "biolink:Cell", "ic": "77.944915021140389", "identifiers": [{"i": "UMLS:C1514096", "l": "Neoplastic Small to Medium-Sized T-Lymphocyte", "d": []}, {"i": "NCIT:C39606", "l": "Neoplastic Small to Medium-Sized T-Lymphocyte", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0229644", "l": "Nonsegmented eosinophil", "d": []}, {"i": "SNOMEDCT:81209003", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1979010", "l": "Cells.CD38+CD138+", "d": []}]}
{"type": "biolink:Cell", "ic": "74.804588241401973", "identifiers": [{"i": "UMLS:C1513928", "l": "Neoplastic B-Lymphoblast", "d": []}, {"i": "NCIT:C37070", "l": "Neoplastic B-Lymphoblast", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5709279", "l": "Autologous Human Peripheral Blood Lymphocytes", "d": []}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "CL:1000123", "l": "metanephric nephron tubule epithelial cell", "d": []}]}
{"type": "biolink:Cell", "ic": "84.75972595860604", "identifiers": [{"i": "UMLS:C1519174", "l": "Salivary Gland Myoepithelial Cell", "d": []}, {"i": "NCIT:C40411", "l": "Salivary Gland Myoepithelial Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "CL:4033039", "l": "lung resident memory CD8-positive, alpha-beta T cell", "d": ["An alpha-beta CD8 T cell that resides in the lung."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1512859", "l": "Intermediate-Sized Neoplastic Germ Cell", "d": []}, {"i": "NCIT:C37133", "l": "Intermediate-Sized Neoplastic Germ Cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1292100", "l": "IgG B lymphocyte", "d": []}, {"i": "SNOMEDCT:115606002", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5552636", "l": "Anti-p53 T-Cell Receptor-Transduced Peripheral Blood Lymphocytes", "d": []}, {"i": "NCIT:C64773", "l": "Anti-p53 T-Cell Receptor-Transduced Peripheral Blood Lymphocytes", "d": ["Human autologous peripheral blood lymphocytes (PBLs) transduced with an anti-p53 T cell receptor gene with potential antineoplastic activity. PBLs are harvested from a patient and pulsed with a retroviral vector that encodes the T-cell receptor gene specific for a mutated form of p53. The transduced PBLs are then expanded in culture. When reintroduced to the patient, these modified PBLs express the anti-p53 T cell receptor which binds to mutant p53-overexpressing tumor cells; PBL-mediated tumor growth inhibition may follow. Many tumor cell types overexpress mutant p53 proteins, which are associated with the loss of apoptosis regulation and abnormal cell proliferation."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C3176884", "l": "Blasts.cytoplasmic CD117", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4518168", "l": "Population of all immature basophils in portion of fluid", "d": []}, {"i": "SNOMEDCT:725439004", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002338", "l": "CD56-positive, CD161-positive immature natural killer cell, human", "d": ["A natural killer cell that is developmentally immature, has the phenotype CD34-negative, CD56-positive, CD117-positive, CD122-positive,and CD161-positive."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157317", "l": "CD15 blasts | Blood | Cell markers", "d": []}]}
{"type": "biolink:Cell", "ic": "83.552982069901191", "identifiers": [{"i": "CL:0002334", "l": "preadipocyte", "d": ["An undifferentiated fibroblast that can be stimulated to form a fat cell."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1267981", "l": "Lymphocyte positive for CD94 antigen", "d": []}, {"i": "SNOMEDCT:117421003", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1276860", "l": "Entire granular polyhedral cells of breast", "d": []}, {"i": "SNOMEDCT:205384000", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5237176", "l": "Autologous Tn-MUC1-specific CAR T-lymphocytes", "d": []}, {"i": "NCIT:C165433", "l": "Autologous Tn-MUC1-specific CAR T-lymphocytes", "d": ["A preparation of autologous T-lymphocytes that have been genetically modified to express a chimeric antigen receptor (CAR) specific for the tumor-associated antigen (TAA) Tn glycoform of mucin-1 (Tn-MUC1; TnMUC1), with potential antineoplastic and immunostimulating activities. Upon re-introduction into the patient, the autologous Tn-MUC1-specific CAR T-lymphocytes specifically recognize and induce selective toxicity in TnMUC1-expressing tumor cells. TnMUC1 is overexpressed in certain tumor types."]}]}
{"type": "biolink:Cell", "ic": "68.042516761614237", "identifiers": [{"i": "UMLS:C1515964", "l": "Anaplastic Cell", "d": []}, {"i": "NCIT:C36734", "l": "Anaplastic Cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157456", "l": "CD3+CD8+ (T8 suppressor) cells | Cerebral spinal fluid | Cell markers", "d": []}]}
{"type": "biolink:Cell", "ic": "54.625647028425007", "identifiers": [{"i": "CL:0000145", "l": "professional antigen presenting cell", "d": ["A cell capable of processing and presenting lipid and protein antigens to T cells in order to initiate an immune response."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157541", "l": "CD4+CD28+ cells | Blood | Cell markers", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:1000699", "l": "kidney resident dendritic cell", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0000410", "l": "CNS long range interneuron", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002200", "l": "oxyphil cell of thyroid", "d": ["An oncocyte located in the thyroid."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0000384", "l": "ligament cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1440241", "l": "Cells.CD11", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0301867", "l": "Forbidden clone", "d": []}, {"i": "SNOMEDCT:24309006", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C4528709", "l": "Autologous Genetically-modified MAGE-A4 C1032 T Cells", "d": []}, {"i": "NCIT:C138107", "l": "Autologous Genetically-modified MAGE-A4 C1032 T Cells", "d": ["Autologous human T-lymphocytes transduced with a retroviral vector encoding a T-cell receptor (TCR) specific for the human melanoma antigen A4 (MAGE-A4), with potential immunostimulatory and antineoplastic activities. Upon leukapheresis, isolation, transduction, expansion ex vivo, and reintroduction into the patient, the autologous genetically-modified MAGE-A4 C1032 T-cells bind to tumor cells expressing MAGE-A4. This may result in both inhibition of growth and increased cell death of MAGE-A4-expressing tumor cells. The tumor-associated antigen MAGE-A4, a member of the MAGE-A family of cancer testis antigens, is overexpressed by a variety of cancer cell types."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0734999", "l": "Exocrine cell", "d": []}]}
{"type": "biolink:Cell", "ic": "74.37742281270377", "identifiers": [{"i": "CL:1001579", "l": "cerebral cortex glial cell", "d": ["Glial cell of cerebral cortex."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C3897770", "l": "Reactive Amniocyte", "d": []}, {"i": "NCIT:C118138", "l": "Reactive Amniocyte", "d": ["Proliferation and aggregation of amniocytes due to a meconium exposure."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1520104", "l": "WA09 Cell Line", "d": []}, {"i": "NCIT:C20310", "l": "WA09", "d": ["Provider: Wisconsin Alumni Research Foundation (WARF), Madison, WI. Information from provider and not independently verified by NIH: Cells are positive for cell markers SSEA-3, SSEA-4, TRA-1-60, TRA-1-81, and alkaline phosphatase; Cells are negative for SSEA-1; Give rise to teratomas containing derivatives of three germ layers in SCID mice; Differentiate in vitro; Cells not yet ready for distribution. Publications: Thomson et al., Science 282, 1145, 1998; Amit et al., Developmental Biology 227, 271, 2000. This cell line meets the criteria for the use of human embryonic stem cells by federally funded researchers."]}]}
{"type": "biolink:Cell", "ic": "68.25778018697109", "identifiers": [{"i": "UMLS:C0027882", "l": "Neurons", "d": []}, {"i": "NCIT:C12623", "l": "Neuron", "d": ["Any of the conducting cells of the nervous system. A typical neuron consists of a cell body, containing the nucleus and the surrounding cytoplasm (perikaryon); several short radiating processes (dendrites); and one long process (the axon), which terminates in twiglike branches (telodendrons) and may have branches (collaterals) projecting along its course."]}, {"i": "MESH:D009474", "l": "Neurons", "d": []}, {"i": "SNOMEDCT:47220008", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5163555", "l": "Epithelial cells.squamous | Bronchoalveolar lavage | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5177623", "l": "Platelets | Platelet rich plasma | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2953062", "l": "Endothelial cell of endocardium of right ventricle", "d": []}]}
{"type": "biolink:Cell", "ic": "84.128890093485552", "identifiers": [{"i": "CL:0001008", "l": "Kit and Sca1-positive hematopoietic stem cell", "d": ["A hematopoietic stem cell that has plasma membrane part Kit-positive, SCA-1-positive, CD150-positive and CD34-negative."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5555040", "l": "Autologous Neoantigen-specific T-lymphocytes GEN-011", "d": []}, {"i": "NCIT:C178447", "l": "Autologous Neoantigen-specific T-lymphocytes GEN-011", "d": ["A preparation of autologous, personalized, immunogenic and tumor neoantigen-specific T-lymphocytes, with potential immunostimulating and antineoplastic activities. Tumor-specific neoantigen targets of autologous CD4+ and/or CD8+ T-cells are identified and T-cells that target immunogenic and stimulatory neoantigens are expanded ex vivo. Upon administration, the autologous neoantigen-specific T-lymphocytes GEN-011 recognize and bind to tumor cells expressing the targeted neoantigens, resulting in a cytotoxic T-lymphocyte (CTL)-mediated immune response against the patient's tumor cells."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C2347368", "l": "Nucleated Blood Cell", "d": []}, {"i": "NCIT:C73126", "l": "Nucleated Blood Cell", "d": ["The cellular material of blood consisting of white blood cells and nucleated red blood cells."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5220577", "l": "Epithelial cells|Urine/Urine sed", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1514742", "l": "Reactive Transitional Cell", "d": []}, {"i": "NCIT:C36915", "l": "Reactive Transitional Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C0229635", "l": "Metamyelocytes", "d": []}, {"i": "NCIT:C13116", "l": "Metamyelocyte", "d": ["A cell derived from a promyelocyte and differentiates into a neutrophil. It is nonproliferative and is usually found in bone marrow. Its nucleus is indented and the chromatin clumped and dense."]}, {"i": "SNOMEDCT:83321009", "d": []}]}
{"type": "biolink:Cell", "ic": "78.185623981295834", "identifiers": [{"i": "UMLS:C1514093", "l": "Neoplastic Small T-Lymphocyte", "d": []}, {"i": "NCIT:C39605", "l": "Neoplastic Small T-Lymphocyte", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5557607", "l": "Autologous Anti-CD20/CD19-targeting Tandem CAR T Cells MB-CART2019.1", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1179160", "l": "Pancreatic centro-acinar cell", "d": []}, {"i": "NCIT:C33254", "l": "Pancreatic Centroacinar Cell", "d": ["A cell with a centrally placed nucleus found in the proximal portion of pancreatic intercalated duct that protrudes into the acinus. It secretes bicarbonate made in the cell by the dissociation of carbonic acid in the presence of carbonic anhydrase II. These cells are thought to act as signal transducers, influencing the degranulation of the acinar cells."]}]}
{"type": "biolink:Cell", "ic": "89.347505587204751", "identifiers": [{"i": "CL:0000831", "l": "mast cell progenitor", "d": ["A progenitor cell of the mast cell lineage. Markers for this cell are FceRIa-low, CD117-positive, CD9-positive, T1/ST2-positive, SCA1-negative, and lineage-negative."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2325931", "l": "Epithelial cell of small intestine", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1520106", "l": "Wisconsin H14 stem cell line", "d": []}, {"i": "NCIT:C20312", "l": "WA14", "d": ["Provider: Wisconsin Alumni Research Foundation (WARF), Madison, WI. Information from provider and not independently verified by NIH: Cells are positive for cell markers SSEA-3, SSEA-4, TRA-1-60, TRA-1-81, and alkaline phosphatase; Cells are negative for SSEA-1. Give rise to teratomas containing derivatives of three germ layers in SCID mice; Differentiate in vitro; Cells not yet ready for distribution. Publication: Thomson et al., Science 282, 1145, 1998. This cell line meets the criteria for the use of human embryonic stem cells by federally funded researchers."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0000754", "l": "type 2 cone bipolar cell (sensu Mus)", "d": ["An OFF-bipolar neuron found in the retina and having connections with cone photoreceptors cells and neurons in the outer half of the inner plexiform layer. The dendritic tree is not well filled and the dendrites are more delicate than in type 1 cells. The axon terminal is bushier and exhibits a dense plexus of varicosities in the inner part of sublamina 1 (Ghosh et al., 2004).  It can be differentiated from other retinal bipolar neurons by its expression of marker genes: Neto1, Lhx3 and Irx-6 (Shekhar, 2016)."]}]}
{"type": "biolink:Cell", "ic": "66.618744678332945", "identifiers": [{"i": "UMLS:C1183495", "l": "Ectodermal cell", "d": []}, {"i": "NCIT:C33935", "l": "Ectoderm Cell", "d": ["An embryonic cell of the outer layer of three germ layers. These cells give rise to the epidermis and neural tissue."]}]}
{"type": "biolink:Cell", "ic": "90.82444074280258", "identifiers": [{"i": "CL:0000529", "l": "pigmented epithelial cell", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002552", "l": "fibroblast of gingiva", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C4763759", "l": "Expanded/Activated Gamma Delta T-cells", "d": []}, {"i": "NCIT:C157634", "l": "Expanded/Activated Gamma Delta T-cells", "d": ["A preparation of gamma delta T-lymphocytes derived from donor T-cells that have been expanded and activated ex-vivo and further depleted of alpha and beta T-cell receptors (TCRs), with potential immunomodulating and antineoplastic activities. Upon administration, these expanded/activated gamma delta (EAGD) T-cells secrete interferon-gamma (IFN-g) and exert direct killing of tumor cells. In addition, these cells activate the immune system to exert a cytotoxic T-lymphocyte (CTL) response against tumor cells. Gamma delta T-lymphocytes play a key role in the activation of the immune system and do not require major histocompatibility complex (MHC)-mediated antigen presentation to exert their cytotoxic effect."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2335231", "l": "Pulmonary interstitial fibroblast", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2330475", "l": "Goblet cell of epithelium of crypt of Lieberkuhn of small intestine", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1449623", "l": "Neuroepithelial Bodies", "d": []}, {"i": "MESH:D046568", "l": "Neuroepithelial Bodies", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4323725", "l": "Cranial neural crest cell group", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:1001581", "l": "lateral ventricle glial cell", "d": ["Glial cell of lateral ventricle."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002221", "l": "keratinized squamous cell of esophagus", "d": ["A squamous cell that has keratin in the esophagus."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4697031", "l": "Cells.CD38+IgM-", "d": []}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "CL:0002630", "l": "actinomycete-type spore", "d": ["A spore formed from bacteria in the order Actinomycetales."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157536", "l": "CD4+ CD26- Cells | Blood | Cell markers", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2924227", "l": "Cells.CD7+CD34+", "d": []}]}
{"type": "biolink:Cell", "ic": "92.728541327098611", "identifiers": [{"i": "CL:0009091", "l": "Leydig stem cell", "d": ["A stem cell found in the interstitial compartment of the neonatal testis; it is capable of self-renewal as well as differentiation into steroidogenic cells (adult Leydig cells). Intermediate stages of development include progenitor Leydig cells and immature Leydig cells."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5709271", "l": "Autologous Hematopoietic Peripheral Blood Stem Cells", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002642", "l": "epithelial cell of esophageal cardiac gland", "d": ["An epithelial cell of the esophageal cardiac gland that occurs both in the proximal and distal esophagus, within the lamina propia."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2325214", "l": "Submandibular ganglion neuron", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4697029", "l": "Cells.CD3+CD8+CD27-", "d": []}]}
{"type": "biolink:Cell", "ic": "82.532694649739099", "identifiers": [{"i": "CL:0002422", "l": "enucleated reticulocyte", "d": ["A reticulocyte lacking a nucleus and showing a basophilic reticulum under vital staining due to the presence of ribosomes."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C3831561", "l": "Allogeneic HLA-A2/4-1BB ligand-expressing Melanoma Vaccine", "d": []}, {"i": "NCIT:C107169", "l": "Allogeneic HLA-A2/4-1BB ligand-expressing Melanoma Vaccine", "d": ["An allogeneic melanoma cell vaccine derived from a cell line with high expression of melanoma associated antigens and genetically modified to express both HLA-A2 and 4-1BB ligand, with potential immunostimulating and antineoplastic activities. Upon administration, the 4-1BB ligand of the allogeneic HLA-A2/4-1BB ligand-expressing melanoma vaccine binds to 4-1BB on activated T-lymphocytes, which induces a strong immune response against HLA-A2 positive melanoma cells."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2333553", "l": "Type L enteroendocrine cell", "d": []}]}
{"type": "biolink:Cell", "ic": "90.82444074280258", "identifiers": [{"i": "UMLS:C1518858", "l": "Pale Brown Fat Cell", "d": []}, {"i": "NCIT:C36970", "l": "Pale Brown Fat Cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5182508", "l": "Synovial lining cells | Synovial fluid | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "ic": "92.728541327098611", "identifiers": [{"i": "UMLS:C0682649", "l": "Proprioceptor", "d": []}, {"i": "NCIT:C13823", "l": "Proprioceptor", "d": ["A primary sensory neuron that acts as a receptor of the somatic afferent component of the nervous system. It is stimulated by the contraction of muscles, movements of joints, and changes in body position."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:4030020", "l": "kidney connecting tubule alpha-intercalated cell", "d": ["A renal alpha-intercalated cell that is part of the renal connecting tubule."]}]}
{"type": "biolink:Cell", "ic": "54.213318955135335", "identifiers": [{"i": "CL:0000566", "l": "angioblastic mesenchymal cell", "d": ["A mesenchymal stem cell capable of developing into blood vessel endothelium."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0945927", "l": "Cells.CD3+HLA-DR+", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C2826113", "l": "M87o-Transduced CD34+ Peripheral Blood Stem Cells", "d": []}, {"i": "NCIT:C82351", "l": "M87o-Transduced CD34+ Peripheral Blood Stem Cells", "d": ["Peripheral blood stem cells (PBSCs) transduced with the retroviral vector M87o encoding for the HIV-1-entry inhibitor peptide membrane-anchored antiviral peptide C46 (maC46). Expression of C46 by M87o-transduced CD34+ peripheral blood stem cells may prevent the fusion of viral and cellular membranes, thereby inhibiting HIV-1 entry. C46 is a membrane-anchored peptide encoding amino acids 628 to 673 of the HIV-1 entry inhibitory transmembrane glycoprotein gp41."]}]}
{"type": "biolink:Cell", "ic": "78.435418415656045", "identifiers": [{"i": "UMLS:C0229659", "l": "Myelomonocyte", "d": []}, {"i": "NCIT:C37041", "l": "Neoplastic Monocyte", "d": ["An abnormal myeloid cell that is present in the peripheral blood of patients with myelomonocytic leukemia."]}, {"i": "SNOMEDCT:41621006", "d": []}]}
{"type": "biolink:Cell", "ic": "55.239069658248042", "identifiers": [{"i": "CL:0000617", "l": "GABAergic neuron", "d": ["A neuron that uses GABA as a vesicular neurotransmitter"]}]}
{"type": "biolink:Cell", "ic": "90.82444074280258", "identifiers": [{"i": "UMLS:C1328818", "l": "Podocytes", "d": []}, {"i": "NCIT:C33334", "l": "Podocyte", "d": ["A modified epithelial cell of the capsular epithelium of the renal glomerulus. It has a small perikaryon and a number of primary and secondary foot-like radiating processes (pedicels) that interdigitate with those of other podocytes and embrace the basal lamina of glomerular capillaries."]}, {"i": "MESH:D050199", "l": "Podocytes", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0546505", "l": "P.B. hemohistioblast", "d": []}]}
{"type": "biolink:Cell", "ic": "83.552982069901191", "identifiers": [{"i": "UMLS:C1514171", "l": "Pleomorphic Connective and Soft Tissue Cell", "d": []}, {"i": "NCIT:C37112", "l": "Pleomorphic Connective and Soft Tissue Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:2000024", "l": "spinal cord medial motor column neuron", "d": ["Any neuron that is part of a spinal cord medial motor column."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1955385", "l": "Spermatozoa.short tail", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2335622", "l": "Serous cell of epithelium of bronchus", "d": []}]}
{"type": "biolink:Cell", "ic": "80.17194633000733", "identifiers": [{"i": "UMLS:C0333825", "l": "Lymphoplasmacytoid Cell", "d": []}, {"i": "NCIT:C37000", "l": "Lymphoplasmacytoid Cell", "d": ["A mononuclear cell slightly larger than a small lymphocyte with an eccentric dark nucleus. It has basophilic cytoplasm and secretes immunoglobulins.  It may contain intranuclear cytoplasmic inclusions (Dutcher bodies) which are PAS-positive."]}, {"i": "SNOMEDCT:59509005", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5556521", "l": "Dabocemagene Autoficel", "d": []}, {"i": "NCIT:C180642", "l": "Dabocemagene Autoficel", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:4040004", "l": "mesenchymal stem cell of orbital adipose tissue", "d": ["Any mesenchymal stem cell of adipose tissue that is part of an orbital region."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1514436", "l": "Primitive Mesenchymal Plump Cell", "d": []}, {"i": "NCIT:C37090", "l": "Primitive Mesenchymal Plump Cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5216216", "l": "Erythrocytes|NCnc|Pt|Pericard fld", "d": []}]}
{"type": "biolink:Cell", "ic": "78.185623981295834", "identifiers": [{"i": "CL:0002487", "l": "cutaneous/subcutaneous mechanoreceptor cell", "d": ["A neuronal receptor that respond to mechanical pressure or distortion in the skin."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1182629", "l": "Ecto-epithelial cell of viscerocranial mucosa", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5667009", "l": "NIB 103", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002266", "l": "type D cell of small intestine", "d": ["A type D cell of the small intestine."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5666822", "l": "Squeezed Red Blood Cells Expressing HPV16 Epitopes SQZ-AAC-HPV", "d": []}, {"i": "NCIT:C184978", "l": "Squeezed Red Blood Cells Expressing HPV16 Epitopes SQZ-AAC-HPV", "d": ["A cell therapy agent composed of autologous red blood cells (RBCs) engineered to act as artificial antigen carriers (AACs) and expressing tumor-specific antigens (TAAs), human papillomavirus (HPV) type 16 epitopes, and containing a Toll-like receptor (TLR) agonist as an activating adjuvant, with potential immunomodulating and antineoplastic activities. Using cell squeeze technology, the RBCs are squeezed (SQZ) and loaded with TAAs and an adjuvant to generate SQZ AACs that appear similar to aged RBCs. Upon administration of the SQZ RBCs expressing HPV16 epitopes SQZ-AAC-HPV, the SQZ RBCs are rapidly taken up by the patient's professional antigen-presenting cells (APCs) similar to the process of natural clearance and destruction of aged RBCs. In turn, the HPV16 epitopes are presented to the immune system and activate the immune system to mount a cytotoxic T-lymphocyte (CTL) immune response against tumor cells expressing HPV16. By mimicking natural aged RBCs, the AACs are able to activate an anti-tumor immune response against the TAA-expressing tumor cells. HPV16 plays an important role in the development of certain types of cancer."]}]}
{"type": "biolink:Cell", "ic": "87.120474278337809", "identifiers": [{"i": "UMLS:C1711302", "l": "Malignant Parathyroid Gland Oncocyte", "d": []}, {"i": "NCIT:C48273", "l": "Malignant Parathyroid Gland Oncocyte", "d": []}]}
{"type": "biolink:Cell", "ic": "67.014669355571556", "identifiers": [{"i": "UMLS:C1514113", "l": "Neoplastic Thyroid Gland Follicular Cell", "d": []}, {"i": "NCIT:C36835", "l": "Neoplastic Thyroid Gland Follicular Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "92.728541327098611", "identifiers": [{"i": "CL:0002411", "l": "Vgamma1.1-positive, Vdelta6.3-negative thymocyte", "d": ["A gamma-delta receptor that expresses Vgamma1.1 but does not express Vdelta6.3 chains in the T-cell receptor."]}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "CL:0002651", "l": "endothelial cell of venous sinus of spleen", "d": ["An endothelial cell that is part of the venous sinus of spleen. This endothelial cell has an elongated, spindle-shaped, flattened morphology that is parallel to long axis of sinus. This cell type rests on a basement membrane interrupted by numerous narrow slits."]}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "CL:0000992", "l": "immature CD11c-low plasmacytoid dendritic cell", "d": ["Immature CD11c-low plasmacytoid dendritic cell is a CD11c-low plasmacytoid dendritic cell that is CD80-low and CD86-low."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0945923", "l": "Cells.CD21", "d": []}]}
{"type": "biolink:Cell", "ic": "86.236661114203869", "identifiers": [{"i": "CL:0002306", "l": "epithelial cell of proximal tubule", "d": ["An epithelial cell of the proximal tubule of the kidney."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0009077", "l": "subcapsular thymic epithelial cell", "d": ["A thymic epithelial cell located within the subcapsular region of the thymus."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1254550", "l": "Toxicopathic Erythrocyte", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4322559", "l": "Set of antigen-presenting cells", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1440239", "l": "Cell positive for CD107a antigen", "d": []}, {"i": "SNOMEDCT:725723007", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1522072", "l": "Skin - Epidermis - Keratinocyte (MMHCC)", "d": []}, {"i": "NCIT:C22542", "l": "Mouse Keratinocyte", "d": []}]}
{"type": "biolink:Cell", "ic": "78.185623981295834", "identifiers": [{"i": "UMLS:C1514074", "l": "Neoplastic Promonocyte", "d": []}, {"i": "NCIT:C37075", "l": "Neoplastic Promonocyte", "d": []}]}
{"type": "biolink:Cell", "ic": "88.140761698499901", "identifiers": [{"i": "CL:4023130", "l": "kisspeptin neuron", "d": ["A neuron that expresses kisspeptin. These neurons are predominantly located in the hypothalamus, but also found in other parts of the brain including the hippocampal dentate gyrus."]}]}
{"type": "biolink:Cell", "ic": "84.128890093485552", "identifiers": [{"i": "UMLS:C1881593", "l": "Malignant Sex Cord-Stromal Cell", "d": []}, {"i": "NCIT:C61416", "l": "Malignant Sex Cord-Stromal Cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C3656575", "l": "Cells.CD158e", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1525455", "l": "Cells.CD33+CD34+", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1440269", "l": "Cells.CD198", "d": []}]}
{"type": "biolink:Cell", "ic": "89.347505587204751", "identifiers": [{"i": "CL:4023014", "l": "L5 vip GABAergic interneuron (Mmus)", "d": ["A vip GABAergic cortical interneuron with a soma found in L5. L5 vip cells have mostly local morphology with some deep-projecting axons. They show only moderate resistance, comparable to that of sst subclass and unlike typical Vip subclass cells that tend to show high input resistance. L5 vip cells show particularly low resting membrane potential."]}]}
{"type": "biolink:Cell", "ic": "80.17194633000733", "identifiers": [{"i": "UMLS:C1515881", "l": "Activated Natural Killer Cell", "d": []}, {"i": "NCIT:C39609", "l": "Activated Natural Killer Cell", "d": ["A cell that acts in a similar manner to a cytotoxic T cell and must be activated like a cytotoxic T cell. However, the killing exhibited by the cell is nonspecific and the cell does not require antigen/MHC recognition on the target cell. The lineage of the natural killer (NK) cell is currently not well understood."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157434", "l": "CD3+CD26+ cells | Blood | Cell markers", "d": []}]}
{"type": "biolink:Cell", "ic": "65.777771579090697", "identifiers": [{"i": "CL:0000023", "l": "oocyte", "d": ["A female germ cell that has entered meiosis."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0017002", "l": "prostate neuroendocrine cell", "d": ["A neuroendocrine cell that is part of the prostate epithelium."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4322817", "l": "CD79B+ B lymphocyte", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C4745003", "l": "Autologous Anti-BCMA-CAR-mRNA-transfected CD8+ T-lymphocytes", "d": []}, {"i": "NCIT:C156706", "l": "Autologous Anti-BCMA-CAR-mRNA-transfected CD8+ T-lymphocytes", "d": ["A preparation of autologous CD8-positive T-lymphocytes that have been genetically modified via transient mRNA transfection to express a chimeric antigen receptor (CAR) specific for the tumor-associated antigen (TAA) human B-cell maturation antigen (BCMA; tumor necrosis factor receptor superfamily member 17; TNFRSF17) and containing, as of yet undisclosed co-stimulatory signaling domains, with potential immunostimulating and antineoplastic activities. Upon administration, autologous anti-BCMA-CAR-mRNA transfected CD8+ T-lymphocytes specifically recognize and induce selective toxicity in BCMA-expressing tumor cells. BCMA, a tumor-specific antigen and a receptor for both a proliferation-inducing ligand (APRIL) and B-cell activating factor (BAFF), is a member of the tumor necrosis factor receptor superfamily (TNFRSF) and plays a key role in plasma cell survival. BCMA is found on the surfaces of plasma cells and overexpressed on malignant plasma cells."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4518161", "l": "Population of all isolated head spermatozoa in portion of fluid", "d": []}, {"i": "SNOMEDCT:725385000", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4684850", "l": "Autologous Anti-CD19/CD22 CAR-T Cells", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5670962", "l": "Partially HLA-matched Multiple TAA-specific Allogeneic T-lymphocytes", "d": []}, {"i": "NCIT:C187028", "l": "Partially HLA-matched Multiple TAA-specific Allogeneic T-lymphocytes", "d": ["A preparation of partially human leukocyte antigen (HLA)-matched allogeneic T-lymphocytes targeting multiple tumor-associated antigens (TAAs), with potential immunomodulating and antineoplastic activities. Upon administration, partially HLA-matched multiple TAA-specific allogeneic T-lymphocytes target and kill tumor cells expressing these TAAs."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0001002", "l": "mature CD8_alpha-negative CD11b-negative dendritic cell", "d": ["Mature CD8_alpha-negative CD11b-negative dendritic cell is a CD8_alpha-negative CD11b-negative dendritic cell that is CD80-high, CD86-high, MHCII-high and is CD83-positive."]}]}
{"type": "biolink:Cell", "ic": "66.408607444211199", "identifiers": [{"i": "CL:0000126", "l": "macroglial cell", "d": ["A neuroglial cell of ectodermal origin, i.e., the astrocytes and oligodendrocytes considered together."]}]}
{"type": "biolink:Cell", "ic": "73.847638787057321", "identifiers": [{"i": "CL:0000114", "l": "surface ectodermal cell", "d": []}]}
{"type": "biolink:Cell", "ic": "69.25985915845861", "identifiers": [{"i": "CL:2000032", "l": "peripheral nervous system neuron", "d": ["A neuron that is part of a peripheral nervous system."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0000367", "l": "sheath cell (sensu Nematoda)", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:1000083", "l": "stratified keratinized epithelial stem cell", "d": []}]}
{"type": "biolink:Cell", "ic": "84.75972595860604", "identifiers": [{"i": "CL:1000191", "l": "pillar cell", "d": ["A rod-like cell in the inner ear, having their heads joined and their bases on the basilar membrane widely separated so as to form a spiral tunnel known as the tunnel of Corti."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1179876", "l": "Myocardial endocrine cell", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0000524", "l": "spheroplast", "d": ["A cell, usually of bacteria or yeast, which has partially lost its cell wall."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C3826603", "l": "Cell metabolism", "d": []}]}
{"type": "biolink:Cell", "ic": "69.071635092918072", "identifiers": [{"i": "UMLS:C1519458", "l": "Neoplastic Spindle-Shaped Fibroblast", "d": []}, {"i": "NCIT:C36955", "l": "Neoplastic Spindle-Shaped Fibroblast", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4322831", "l": "Type 2C muscle fiber", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5706336", "l": "Autologous Anti-CD19/CD20 CAR-T Cells C-CAR039", "d": []}]}
{"type": "biolink:Cell", "ic": "73.357135392541679", "identifiers": [{"i": "CL:4023018", "l": "pvalb GABAergic cortical interneuron", "d": ["A GABAergic interneuron located in the cerebral cortex that expresses Parvalbumin."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0682701", "l": "Central neuron", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5174655", "l": "Neutrophils.vacuolated | Blood | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5555145", "l": "Allogeneic Anti-CD5-IL-15/IL-15sushi-safety Switch CAR T Cells", "d": []}, {"i": "NCIT:C178587", "l": "Allogeneic Anti-CD5-IL-15/IL-15sushi-safety Switch CAR T Cells", "d": ["A preparation of allogeneic T-lymphocytes that have been transduced with a lentiviral vector to express a chimeric antigen receptor (CAR) consisting of a humanized anti-CD5 single chain variable fragment (scFv) domain linked to a interleukin (IL)-15/IL-15sushi domain and a safety switch, with potential immunostimulating and antineoplastic activities. Upon administration, the allogeneic anti-CD5-IL-15/IL-15sushi-safety switch CAR T cells target and bind to CD5-expressing tumor cells, thereby inducing selective cytotoxicity in CD5-expressing tumor cells. The IL-15/IL-15sushi domain activates and increases the levels of natural killer (NK) cells and memory CD8+ T-cells. The memory T-cells enhance the secretion of the cytokine interferon-gamma (IFN-g), which further potentiates the immune response against tumor cells. This may increase tumor cell killing and decrease tumor cell proliferation. The pro-survival cytokine IL-15 regulates CD8+ T and NK cell development, activation and proliferation. The safety switch, composed of two rituximab (RTX)-binding epitope sites, allows for the selective elimination of the CAR-T cells through the administration of RTX. CD5, a T-cell associated antigen, is expressed in many T-cell lymphomas and leukemias."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1519682", "l": "Tumor Infiltrating Lymphocytes-N2-Transduced", "d": []}, {"i": "NCIT:C29478", "l": "Tumor Infiltrating Lymphocytes-N2-Transduced", "d": ["A preparation of lymphocytes harvested from a patient and genetically modified ex vivo for use in gene therapy for the patient's cancer.  Ex vivo, the lymphocytes are transduced with the N2 retroviral vector, which is modified to express a gene whose protein product either kills tumor cells or elicits specific anti-tumor immunity. Genetically modified lymphocytes are infused back into the patient from whom they were harvested, locate to the tumor site, and express the candidate protein that kills tumor cells or stimulates host anti-tumor immunity. (NCI04)"]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5690736", "l": "Gut-Associated Lymphoid Tissue M Cells", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0933799", "l": "Ciliated columnar cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0026609", "l": "Motor Neurons", "d": []}, {"i": "MESH:D009046", "l": "Motor Neurons", "d": []}, {"i": "SNOMEDCT:31513005", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5179517", "l": "Reticulocytes | Blood | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5418084", "l": "Allogeneic Anti-CD20 CAR T-cells LUCAR-20S", "d": []}, {"i": "NCIT:C174397", "l": "Allogeneic Anti-CD20 CAR T-cells LUCAR-20S", "d": ["A preparation of donor-derived T-lymphocytes that have been genetically modified to express a chimeric antigen receptor (CAR) targeting the tumor-associated antigen (TAA) CD20 (cluster of differentiation 20), with potential immunostimulating and antineoplastic activities. Upon administration, allogeneic anti-CD20 CAR T-cells LUCAR-20S specifically recognize and kill CD20-expressing tumor cells. The CD20 antigen, a non-glycosylated cell surface phosphoprotein, is a B-cell specific cell surface antigen expressed in B-cell lineage malignancies."]}]}
{"type": "biolink:Cell", "ic": "92.728541327098611", "identifiers": [{"i": "CL:0010006", "l": "cardiac blood vessel endothelial cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5163730", "l": "Erythrocytes | Vaginal | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0009104", "l": "B cell zone reticular cell", "d": ["A fibroblastic reticular cell found in the lymph node germinal center dark zone (B cell zone)."]}]}
{"type": "biolink:Cell", "ic": "83.023198044254755", "identifiers": [{"i": "CL:0000520", "l": "prokaryotic cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4763654", "l": "Therapeutic Ex Vivo-expanded Allogeneic gamma delta T-cells", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0007012", "l": "non-terminally differentiated odontoblast", "d": ["Odontoblast that non-terminally differentiated, located in the odontogenic papilla and dentine tissue, and transforms from a odontoblast cell."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0011007", "l": "paraxial cell", "d": ["A cell in the area of mesoderm in the neurulating embryo that flanks and forms simultaneously with the neural tube. The cells of this region give rise to somites."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5174656", "l": "Neutrophils.vacuolated+Segmented | Blood | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0000418", "l": "arcade cell", "d": ["An epithelial cell found in C. elegans that firmly hold the outer body wall and the lips to the inner cylinder of the pharynx in a manner that keeps these organs from breaking apart, while still giving each organ freedom of movement during feeding."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2334307", "l": "Paneth cell of epithelium proper of small intestine", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5179962", "l": "Round cells | Semen | Fertility testing", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1184141", "l": "Myoepithelial cell of quarternary lactiferous duct", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5216268", "l": "Metamyelocytes|NCnc|Pt|Body fld", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0003012", "l": "G9 retinal ganglion cell", "d": ["A mono-stratified retinal ganglion cell that has a large dendritic field and a medium dendritic arbor with post synaptic terminals in sublaminar layer S1 and S2."]}]}
{"type": "biolink:Cell", "ic": "52.491931192834926", "identifiers": [{"i": "CL:0000007", "l": "early embryonic cell (metazoa)", "d": ["A cell found in the embryo before the formation of all the gem layers is complete."]}]}
{"type": "biolink:Cell", "ic": "66.969489883774216", "identifiers": [{"i": "CL:4023063", "l": "medial ganglionic eminence derived interneuron", "d": ["An interneuron that is derived from the medial ganglionic eminence."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C4085937", "l": "Adipose-derived Stromal Vascular Fraction Cells", "d": []}, {"i": "NCIT:C124992", "l": "Adipose-derived Stromal Vascular Fraction Cells", "d": ["A population of stromal vascular fraction (SVF) cells derived from autologous adipose tissue, with potential tissue regenerative activity. SVF cells are obtained through liposuction and contain multiple cell types, including adipose-derived stem cells (ADSCs), mesenchymal and endothelial progenitor cells, leukocyte subtypes, lymphatic cells, pericytes, and vascular smooth muscle cells. The SVF cells are processed in such a way as to contain a reproducible and consistent composition of heterogeneous cells. Upon processing and administration, the adipose-derived SVF cells can differentiate into different tissue types, support neovascularization, replace cells and repair injured issue."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2335437", "l": "Type K enteroendocrine cell", "d": []}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "UMLS:C1708874", "l": "Malignant Epithelioid Fibroblast", "d": []}, {"i": "NCIT:C49029", "l": "Malignant Epithelioid Fibroblast", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C4524565", "l": "Hematopoietic Progenitor Cells from Apheresis", "d": []}, {"i": "NCIT:C133328", "l": "Hematopoietic Progenitor Cells from Apheresis", "d": ["Peripheral blood collected by apheresis as a source of hematopoietic progenitor cells."]}]}
{"type": "biolink:Cell", "ic": "90.82444074280258", "identifiers": [{"i": "UMLS:C1512995", "l": "Maria ES Cell Line", "d": []}, {"i": "NCIT:C20274", "l": "Maria ES Cell Line", "d": []}]}
{"type": "biolink:Cell", "ic": "83.552982069901191", "identifiers": [{"i": "CL:0000841", "l": "mature conventional dendritic cell", "d": ["A mature cell of the conventional dendritic cell lineage, characterized by a high capacity for antigen presentation and typically found in a lymph node."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1514660", "l": "RL21", "d": []}, {"i": "NCIT:C20294", "l": "RL21", "d": ["Provider: Reliance Life Sciences, Mumbai, India. No information from provider. This cell line meets the criteria for the use of human embryonic stem cells by federally funded researchers."]}]}
{"type": "biolink:Cell", "ic": "70.216808612803263", "identifiers": [{"i": "CL:0000488", "l": "visible light photoreceptor cell", "d": ["A photoreceptor cell that detects visible light."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0007008", "l": "notochordal vacuole cell", "d": ["Notochordal cell that is inner portion of the notochord and becomes vacuolated as development proceeds."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002591", "l": "smooth muscle cell of the pulmonary artery", "d": ["A smooth muscle of the pulmonary artery."]}]}
{"type": "biolink:Cell", "ic": "88.140761698499901", "identifiers": [{"i": "CL:0000851", "l": "neuromast mantle cell", "d": ["Neuromast mantle cell is a non-sensory cell. Neuromast mantle cells surround the neuromast support cells and neuromast hair cells, separating the neuromast from the epidermis, and secrete cupula in which the ciliary bundles of all the hair cells are embedded."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5171700", "l": "Lymphocytes.immature/100 leukocytes | Amniotic fluid | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "ic": "82.532694649739099", "identifiers": [{"i": "CL:0002140", "l": "acinar cell of sebaceous gland", "d": ["A sebum secreting cell of the skin that secretes sebum into the hair follicles."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002478", "l": "F4/80-negative adipose macrophage", "d": ["An adipose macrophage that does not express F4/80but is MHC-II-positive. This cell type exhibits autofluorescence under typical flow cyometry conditions."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0003018", "l": "retinal ganglion cell B3 inner", "d": ["A retinal ganglion B3 cell with dentrites terminating in S4."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0444746", "l": "Endocyte", "d": []}, {"i": "SNOMEDCT:262506003", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0009081", "l": "specified double negative thymocyte (Homo sapiens)", "d": ["The human equivalent of a DN2 thymocyte; typically contains two phases, in the latter of which these thymocytes begin the process of beta selection."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1184810", "l": "Endocardial cell", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:4033029", "l": "diffuse bipolar 3a cell", "d": ["An OFF calbindin-positive bipolar cell that has a large dendritic field and stratifies narrowly close to the middle of the inner plexiform layer. Its axon terminal is characterized by regularly branching and varicose processes resembling beads on a string. Most of DB3a contacts with cones are triad-associated."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1441144", "l": "Reticulocytes.punctate", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5427579", "l": "Rods.right", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002456", "l": "CD8_alpha-positive plasmacytoid dendritic cell", "d": ["A CD11c-low plasmacytoid dendritic cell that is CD8alpha-positive and CD4-positive."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0947505", "l": "Cells.CD30", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2334601", "l": "Intermediate cell of urothelium", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1179475", "l": "Stem cell of gastric gland", "d": []}]}
{"type": "biolink:Cell", "ic": "60.614083926907639", "identifiers": [{"i": "UMLS:C1512972", "l": "Malignant Transitional Cell", "d": []}, {"i": "NCIT:C36778", "l": "Malignant Transitional Cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2334670", "l": "Tracheal goblet cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5170956", "l": "Leukocytes other | Peritoneal fluid | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5174628", "l": "Neutrophils.agranular | Blood | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5186733", "l": "Leukocytes | Blood product unit | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1440403", "l": "Cells.t(12;16)(q13;p11.2)(DDIT3,FUS)", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0000951", "l": "IgE short lived plasma cell", "d": ["A short lived plasma cell that secretes IgE."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1135922", "l": "Myoblasts, Skeletal", "d": []}, {"i": "MESH:D032448", "l": "Myoblasts, Skeletal", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002655", "l": "epithelial cell of stratum spinosum of esophageal epithelium", "d": ["An epithelial cell of stratum spinosum of esophageal epithelium."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1267979", "l": "Lymphocyte positive for CD91 antigen", "d": []}, {"i": "SNOMEDCT:117419008", "d": []}]}
{"type": "biolink:Cell", "ic": "86.236661114203869", "identifiers": [{"i": "CL:2000089", "l": "dentate gyrus granule cell", "d": ["A granule cell that has soma location in the dentate gyrus cell layer of the hippocampal formation and has an elliptical cell body and characteristic cone-shaped tree of spiny apical dendrites. The branches extend throughout the molecular layer and the distal tips of the dendritic tree end just at the hippocampal fissure or at the ventricular surface. The dentate gyrus granule cell is the principal cell type of the dentate gyrus."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:4023097", "l": "arachnoid barrier cell", "d": ["A mesothelial fibroblast of the arachnoid barrier layer. Arachnoid barrier cells make up the tight-junctioned layer in the leptomeninx that functions as the physiologic barrier between the cerebrospinal fluid in the subarachnoid space and the fenestrated capillaries in the dura."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C0014762", "l": "Erythroblasts", "d": []}, {"i": "NCIT:C12527", "l": "Erythroblast", "d": ["An immature, nucleated erythrocyte occupying the stage of erythropoiesis that follows formation of erythroid progenitor cells and precedes formation of reticulocytes."]}, {"i": "NCIT:C73125", "l": "Nucleated Red Blood Cell", "d": ["Red blood cells that are at the last stage of development, still containing a nucleus, that are found in the bone marrow and occasionally in the peripheral blood."]}, {"i": "MESH:D004900", "l": "Erythroblasts", "d": []}, {"i": "SNOMEDCT:29208003", "d": []}, {"i": "SNOMEDCT:84227004", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2362047", "l": "Macroblasts", "d": []}]}
{"type": "biolink:Cell", "ic": "53.893509554328418", "identifiers": [{"i": "CL:0000081", "l": "blood cell", "d": ["A cell found predominately in the blood."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0682548", "l": "Amphophilic cell", "d": []}]}
{"type": "biolink:Cell", "ic": "89.347505587204751", "identifiers": [{"i": "CL:0000525", "l": "syncytiotrophoblast cell", "d": ["A cell from the outer syncytial layer of the trophoblast of an early mammalian embryo, directly associated with the maternal blood supply. It secretes hCG in order to maintain progesterone secretion and sustain a pregnancy."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C0229629", "l": "Polychromatophilic erythroblast", "d": []}, {"i": "NCIT:C13131", "l": "Polychromatic Erythroblast", "d": []}, {"i": "SNOMEDCT:16779009", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C2981629", "l": "Anti-CD19-CAR Retroviral Vector-Transduced Autologous T Cells", "d": []}, {"i": "NCIT:C88055", "l": "Anti-CD19-CAR Retroviral Vector-Transduced Autologous T Cells", "d": ["A preparation of autologous peripheral blood T-lymphocytes (PBTL) that have been genetically modified to express a chimeric antigen receptor (CAR) consisting of an anti-CD19 scFv (single chain variable fragment) coupled to the costimulatory signaling domain CD28 and the zeta chain of the T-cell receptor (TCR)/CD3 complex (CD3 zeta), with potential immunostimulating and antineoplastic activities. Upon administration, anti-CD19-CAR retroviral vector-transduced autologous T cells direct the T-lymphocytes to CD19-expressing tumor cells, thereby inducing selective toxicity in CD19-expressing tumor cells. CD19 antigen is a B-cell specific cell surface antigen expressed in all B-cell lineage malignancies. CD3 zeta is one of several membrane-bound polypeptides found in the TCR/CD3 complex, which regulates both the assembly of complete TCR complexes and their expression on the cell surface. CD28 is essential for CD4+ T-cell proliferation, interleukin-2 production, and T-helper type-2 (Th2) development."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4510890", "l": "Blast cell positive for CD5 antigen", "d": []}, {"i": "SNOMEDCT:724316000", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:4023090", "l": "small basket cell", "d": ["A basket cell with axonal arbors composed of frequent, short, curvy axonal branches that tend to be near their somata and within the same layer."]}]}
{"type": "biolink:Cell", "ic": "87.120474278337809", "identifiers": [{"i": "CL:0002117", "l": "IgG-negative class switched memory B cell", "d": ["A class switched memory B cell that lacks IgG on the cell surface."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0229472", "l": "Cell of Hensen", "d": []}, {"i": "SNOMEDCT:57870006", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157395", "l": "CD22 blasts | XXX | Cell markers", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5401593", "l": "Adipose-Derived Mesenchymal Stem Cells: Autologous or Allogeneic Origins", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5401389", "l": "Conditionally Reprogrammed Cells", "d": []}, {"i": "NCIT:C172257", "l": "Conditionally Reprogrammed Cells", "d": ["A cellular sample derived from epithelial cells isolated from a tissue sample that were rapidly expanded in a monolayer culture in the presence of irradiated mouse cells and a Rho kinase (ROCK) inhibitor. Under these conditions the cells are reprogrammed to be more stem-like but the reprogramming is conditional. When the cells are transferred to cultures that mimic in vivo environments they become differentiated and can form structures that resemble the tissue from which they were derived."]}]}
{"type": "biolink:Cell", "ic": "70.071335352100078", "identifiers": [{"i": "CL:0000806", "l": "DN2 thymocyte", "d": ["A thymocyte that has the phenotype CD4-negative, CD8-negative, CD44-positive, and CD25-positive."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157407", "l": "CD24 cells | Blood | Cell markers", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5163435", "l": "Eosinophils | Blood | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0011015", "l": "amoeboid sperm cell", "d": ["A motile sperm cell that contain no F-actin, and their motility is powered by a dynamic filament system."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4760444", "l": "Adoptive immunotherapy agent CTL019", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:4033002", "l": "neuroendocrine cell of epithelium of crypt of Lieberkuhn", "d": ["A(n) neuroendocrine cell that is part of a(n) epithelium of crypt of Lieberkuhn."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:1001587", "l": "uterine cervix glandular cell", "d": ["Glandular cell of uterine cervix epithelium."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2335688", "l": "Transitional myocyte of posterior internodal tract", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5167387", "l": "Histiocytes | Nose | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5206754", "l": "Anti-CD70 CAR-expressing T Lymphocytes", "d": []}, {"i": "NCIT:C162699", "l": "Anti-CD70 CAR-expressing T Lymphocytes", "d": ["A preparation of human T-lymphocytes transduced with a recombinant viral vector encoding a chimeric T-cell receptor (chimeric antigen receptor or CAR) consisting of one or more binding domains that target the tumor-associated antigen (TAA) CD70 (CD27 ligand; tumor necrosis factor superfamily member 7; TNFSF7) fused to one or more co-stimulatory TCR-signaling domains, with potential immunostimulating and antineoplastic activities. Upon administration, the anti-CD70 CAR-expressing T-lymphocytes, express anti-CD70-CAR on their cell surfaces and bind to the CD70 antigen on tumor cell surfaces thereby neutralizing the activity of CD70. This may induce antibody-dependent cellular cytotoxicity (ADCC) against CD70-expressing tumor cells. CD70, a cytokine belonging to the tumor necrosis superfamily (TNFSF) and the ligand for the costimulatory receptor CD27, is expressed on the surfaces of various types of cancer cells; its overexpression may play an important role in the evasion of immune surveillance."]}]}
{"type": "biolink:Cell", "ic": "92.728541327098611", "identifiers": [{"i": "UMLS:C1514205", "l": "Polylobated T-Lymphocyte", "d": []}, {"i": "NCIT:C39599", "l": "Polylobated T-Lymphocyte", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C0023517", "l": "Nongranular leukocyte", "d": []}, {"i": "NCIT:C12534", "l": "Non-Granular Leukocyte", "d": ["A white blood cell that lacks cytoplasmic granules with an affinity for specific biological stains; typically, a lymphocyte, monocyte, or plasma cell."]}, {"i": "MESH:D007963", "l": "Leukocytes, Mononuclear", "d": []}]}
{"type": "biolink:Cell", "ic": "89.347505587204751", "identifiers": [{"i": "UMLS:C0014467", "l": "eosinophil", "d": []}, {"i": "NCIT:C12532", "l": "Eosinophil", "d": ["Granular leukocytes with a nucleus that usually has two lobes connected by a slender thread of chromatin, and cytoplasm containing coarse, round granules that are uniform in size and stainable by eosin."]}, {"i": "MESH:D004804", "l": "Eosinophils", "d": []}, {"i": "SNOMEDCT:14793004", "d": []}]}
{"type": "biolink:Cell", "ic": "89.347505587204751", "identifiers": [{"i": "CL:0000846", "l": "vestibular dark cell", "d": ["An epithelial cell of the vestibular sensory organ that is characterized by intense enzymatic activities and numerous basal membrane infoldings."]}]}
{"type": "biolink:Cell", "ic": "88.140761698499901", "identifiers": [{"i": "UMLS:C1881768", "l": "Melanoma Cell with Large Nucleus and Abundant Pale Cytoplasm", "d": []}, {"i": "NCIT:C62342", "l": "Melanoma Cell with Large Nucleus and Abundant Pale Cytoplasm", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5171669", "l": "Lymphocytes | Urine sediment | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "ic": "87.120474278337809", "identifiers": [{"i": "CL:4030027", "l": "GABAergic amacrine cell", "d": ["An amacrine cell that uses GABA as a neurotransmitter."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5401597", "l": "Human Menstrual Blood-derived Stem Cells", "d": []}]}
{"type": "biolink:Cell", "ic": "74.804588241401973", "identifiers": [{"i": "CL:1000272", "l": "lung secretory cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2339921", "l": "Epithelial cell of uterus", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2333402", "l": "Ciliary ganglion neuron", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1519741", "l": "UC06", "d": []}, {"i": "NCIT:C20306", "l": "UC06", "d": ["Provider: University of California, San Francisco, CA. Information from provider and not independently verified by NIH: Cells have normal morphology and a normal female karyotype. Cells differentiate in vitro into all three germ layers; Cells are positive for cell marker Oct-4, SSEA-3, SSEA-4, and alkaline phosphatase; Cells are negative for SSEA-1; Cells will be available only for collaboration once the MTA is completed. This cell line meets the criteria for the use of human embryonic stem cells by federally funded researchers."]}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "UMLS:C0242633", "l": "T-helper cell type 2", "d": []}, {"i": "NCIT:C12540", "l": "Type 2 Helper Cell", "d": ["Type 2 Helper Cells are a subset of helper-inducer T-lymphocytes which synthesize and secrete the interleukins IL-4, IL-5, IL-6, and IL-10. These cytokines influence B-cell development and antibody production as well as augmenting humoral responses."]}, {"i": "MESH:D018418", "l": "Th2 Cells", "d": []}, {"i": "SNOMEDCT:418340005", "d": []}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "UMLS:C1709585", "l": "Pluripotent Primordial Germ Cell", "d": []}, {"i": "NCIT:C45735", "l": "Pluripotent Primordial Germ Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:4033021", "l": "myoepithelial cell of trachea gland", "d": ["A myoepithelial cell that is part of a submucosal gland of the trachea."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002249", "l": "primitive cardiac myocyte", "d": ["A stem cell that can differentiate into a cardiac myocyte."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5170945", "l": "Leukocytes | Vaginal | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5416839", "l": "Amniotic Epithelial Cells", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:4030048", "l": "striosomal D1 medium spiny neuron", "d": ["A DRD1-expressing medium spiny neuron that is part of a striosome of dorsal striatum."]}]}
{"type": "biolink:Cell", "ic": "82.532694649739099", "identifiers": [{"i": "CL:0002204", "l": "brush cell", "d": ["A cell type found in the gastrointestinal and respiratory tracts that is characterized by the presence of a tuft of blunt, squat microvilli (120-140 per cell). Function of this cell type is not known."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0228007", "l": "Prespermatogonia", "d": []}, {"i": "SNOMEDCT:64216006", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1545463", "l": "CD3+CD56+ cells", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5418871", "l": "Autologous Multi-lineage Potential Cells", "d": []}, {"i": "NCIT:C170908", "l": "Autologous Multi-lineage Potential Cells", "d": ["A preparation of autologous multi-lineage potential cells (AMPC) which were induced to de-differentiate from somatic leukocytes from peripheral blood, with potential immunomodulating and antineoplastic activities. Upon introduction into the patient, the AMPC may help replace the abnormal cells in the body to create healthy bone marrow in the treatment of acute myeloid leukemia (AML)."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5690738", "l": "Bronchus-Associated Lymphoid Tissue M Cells", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002337", "l": "keratinocyte stem cell", "d": ["A stem cell located in the bulge of the hair follicle that can give rise to regenerate the new follicle with each hair cycle and to reepithelialize the epidermis during wound repair."]}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "CL:1000354", "l": "microfold cell of epithelium of intestinal villus", "d": ["A M cell that is part of the epithelium of intestinal villus."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1440315", "l": "Cells.CD45RA", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2331946", "l": "Microfold cell of epithelium proper of duodenum", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5166082", "l": "Granulocytes | Dialysis fluid peritoneal | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5560983", "l": "Gintuit Bovine Cellular Sheet", "d": []}]}
{"type": "biolink:Cell", "ic": "82.532694649739099", "identifiers": [{"i": "UMLS:C5700103", "l": "Doughnut Cell", "d": []}, {"i": "NCIT:C39680", "l": "Doughnut Cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5163709", "l": "Erythrocytes | Blood cord | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "ic": "85.457082654197222", "identifiers": [{"i": "UMLS:C1514272", "l": "Postgerminal Center B-Lymphocyte of Unknown Differentiation Stage", "d": []}, {"i": "NCIT:C38341", "l": "Postgerminal Center B-Lymphocyte of Unknown Differentiation Stage", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002531", "l": "mature CD1a-positive dermal dendritic cell", "d": ["A mature CD1a-positive dermal dendritic cell is CD80-high, CD83-positive, CD86-high, and MHCII-high."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4322824", "l": "CD40+ B lymphocyte", "d": []}]}
{"type": "biolink:Cell", "ic": "53.12782148120133", "identifiers": [{"i": "CL:0000723", "l": "somatic stem cell", "d": ["A stem cell that can give rise to cell types of the body other than those of the germ-line."]}]}
{"type": "biolink:Cell", "ic": "82.076046914303362", "identifiers": [{"i": "UMLS:C1518068", "l": "Popcorn Cell", "d": []}, {"i": "NCIT:C37027", "l": "Popcorn Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "80.869303025598512", "identifiers": [{"i": "CL:0000336", "l": "adrenal medulla chromaffin cell", "d": ["A cell found within the adrenal medulla that secrete biogenic amine hormones upon stimulation."]}]}
{"type": "biolink:Cell", "ic": "72.370703631459492", "identifiers": [{"i": "UMLS:C1519372", "l": "Glandular cell of small intestine", "d": []}, {"i": "NCIT:C33566", "l": "Small Intestinal Glandular Cell", "d": ["A glandular cell found in the epithelium of the small intestine."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5239341", "l": "WT1-loaded Artificial Adjuvant Vector Cell Immunotherapeutic ASP7517", "d": []}, {"i": "NCIT:C169049", "l": "WT1-loaded Artificial Adjuvant Vector Cell Immunotherapeutic ASP7517", "d": ["A preparation of artificial adjuvant vector cells (aAVCs) composed of cells from the cell line HEK293, which is derived from human embryonic kidney cells, that are transfected with the natural killer T (NKT) immune cell receptor cluster of differentiation 1d (CD1d) and loaded with the glycolipid and CD1d ligand alpha-galactosylceramide (alpha-GalCer) on the cell surface, and loaded with the full-length tumor-associated antigen (TAA) Wilms' tumor 1 (WT1), with potential immunomodulating and antineoplastic activities. Upon administration of the WT1-loaded aAVC immunotherapeutic ASP7517, the alphaGalCer on the cell surface activates invariant NKT (iNKT) cells, thereby eliciting WT1-specific NKT cell responses against ASP7517. This in turn activates a natural killer (NK) cell response against WT1-expressing tumor cells. Also, the WT1 released from destroyed ASP7517 is taken up by antigen-presenting cells (APCs), mainly by dendritic cells (DCs), which in turn activates cytotoxic T-lymphocytes (CTL) and results in a CTL-mediated immune response against WT1-expressing tumor cells, thereby further destroying WT1-expressing tumor cells. In addition, the activation of antigen-specific memory T cells provides long-lasting anti-tumor effects against the WT1-expressing tumor cells."]}]}
{"type": "biolink:Cell", "ic": "80.869303025598512", "identifiers": [{"i": "CL:0000900", "l": "naive thymus-derived CD8-positive, alpha-beta T cell", "d": ["A CD8-positive, alpha-beta T cell that has not experienced activation via antigen contact and has the phenotype CD45RA-positive, CCR7-positive and CD127-positive. This cell type is also described as being CD25-negative, CD62L-high and CD44-low."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4277577", "l": "A549 Cells", "d": []}, {"i": "MESH:D000072283", "l": "A549 Cells", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:1000330", "l": "serous cell of epithelium of trachea", "d": ["A serous secreting cell that is part of the epithelium of trachea."]}]}
{"type": "biolink:Cell", "ic": "88.140761698499901", "identifiers": [{"i": "CL:0000652", "l": "pinealocyte", "d": ["This cell type produces and secretes melatonin and forms the pineal parenchyma. Extending from each cell body, which has a spherical, oval or lobulated mucleus, are one or more tortuous basophilic processes, containing parallel microtubules known as synaptic ribbons. These processes end in expanded terminal buds near capillaries or less, frequently, ependymal cells of the pineal recess. The terminal buds contain granular endoplasmic reticulum, mitochondria and electron-dense cored vesicles, which store monoamines and polypeptide hormones, release of which appears to require sympathetic innervation."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1518075", "l": "Lymphokine-activated natural killer cell", "d": []}, {"i": "NCIT:C33041", "l": "Lymphokine-Activated Natural Killer Cell", "d": ["A natural killer cell, activated by a soluble cytokine released by a lymphocyte in response to an antigen. It is important in immune response."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5186854", "l": "Normoblasts | Fetus | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0009029", "l": "mesothelial cell of appendix", "d": ["A mesothelial cell that is located in a vermiform appendix."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C4763574", "l": "CD45RA-depleted Donor T-lymphocytes", "d": []}, {"i": "NCIT:C157369", "l": "CD45RA-depleted Donor T-lymphocytes", "d": ["A preparation of donor lymphocytes that have been depleted of CD45RA-positive cells, that can potentially be used for immune reconstitution purposes. CD45RA depletion results in a cellular product that contains a high amount of memory T-cells (Tm). Upon infusion of the allogeneic CD45RA-depleted T-lymphocytes after a hematopoietic cell transplantation (HCT), these cells provide Tm recovery and are able to prevent viral infections. The depletion of the CD45RA-positive cells reduces the risk of graft-versus-host disease (GvHD) upon infusion. CD45RA is expressed on naive T-cells, whereas Tm cells are CD45RA-negative. Naive T-cells have the potential to induce GvHD."]}]}
{"type": "biolink:Cell", "ic": "67.937454763326897", "identifiers": [{"i": "CL:0000850", "l": "serotonergic neuron", "d": ["A neuron that releases serotonin as a neurotransmitter."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5670750", "l": "Autologous MUC1-activated T-cells", "d": []}, {"i": "NCIT:C186784", "l": "Autologous MUC1-activated T-cells", "d": ["A preparation of autologous T-lymphocytes that have been activated against the tumor associated antigen (TAA) mucin-1 (MUC1), with potential immunomodulating and antineoplastic activities. Upon re-introduction into the patient, autologous MUC1-activated T-cells specifically recognize and induce selective toxicity in MUC1-expressing tumor cells. MUC1, a glycoprotein overexpressed on the surface of a variety of cancer cells, plays a key role in tumor cell survival and proliferation."]}]}
{"type": "biolink:Cell", "ic": "92.728541327098611", "identifiers": [{"i": "UMLS:C1522667", "l": "Leukocyte - Monocyte (MMHCC)", "d": []}, {"i": "NCIT:C22586", "l": "Mouse Monocyte", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0333736", "l": "Alzheimer type II glial cell", "d": []}, {"i": "SNOMEDCT:29209006", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0000949", "l": "IgD plasmablast", "d": ["A plasmablast that secretes IgD, and which occur in a small proportion of B cells in the adult."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2331996", "l": "Gastric goblet cell", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C2698146", "l": "Anti-Her-2-CAR Retroviral Vector-Transduced Autologous Peripheral Blood Lymphocytes", "d": []}, {"i": "NCIT:C79834", "l": "Anti-Her-2-CAR Retroviral Vector-Transduced Autologous Peripheral Blood Lymphocytes", "d": ["Autologous human peripheral blood lymphocytes (PBLs) transduced with a retroviral vector encoding an anti-Her-2 (epidermal growth factor receptor 2) chimeric T cell receptor (chimeric antigen receptor or CAR) gene with potential immunostimulatory and antineoplastic activities. Autologous PBLs from a patient with Her-2-positive cancer are pulsed with a retroviral vector that encodes the CAR gene specific for Her-2. After expansion in culture and reintroduction into the patient, anti-Her-2-CAR retroviral vector-transduced autologous peripheral blood lymphocytes, which express anti-Her-2-CAR on their cell surfaces, bind to Her-2 antigen on tumor cell surfaces. Subsequently, Her-2-expressing tumor cells may be lysed. Her-2 (ErbB-2), a receptor tyrosine kinase (RTK) overexpressed by a variety of cancer cell types, belongs to the EGFR superfamily and plays key roles in both tumor cell proliferation and tumor angiogenesis."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2953656", "l": "Set of glioblasts", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157237", "l": "CD10 cells | Blood | Cell markers", "d": []}]}
{"type": "biolink:Cell", "ic": "72.683459462529498", "identifiers": [{"i": "CL:1000746", "l": "glomerular cell", "d": []}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "CL:0001004", "l": "immature CD8_alpha-positive CD11b-negative dendritic cell", "d": ["Immature CD8_alpha-positive CD11b-negative dendritic cell is a CD8_alpha-positive CD11b-negative dendritic cell that is CD80-low, CD86-low, and MHCII-low."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C3827167", "l": "Autologous Lymphoid Effector Cells Specific Against Tumor Cells", "d": []}, {"i": "NCIT:C112495", "l": "Autologous Lymphoid Effector Cells Specific Against Tumor Cells", "d": ["A preparation of cytotoxic, autologous lymphoid effector cells specifically targeted towards tumor cells, with potential immunomodulating and antineoplastic activities. The autologous lymphoid effector cells are prepared by drawing a blood sample containing the required precursors for CD4+ helper T-cells, CD8+ cytotoxic T-cells, and natural killer (NK) cells from a cancer patient. The precursor cells are activated, selected and expanded to generate mature autologous lymphoid effector cells with the potential for enhanced tumor recognition. Upon readministration into the patient, the autologous lymphoid effector cells may induce both humoral and cellular immune responses against tumor cells. This may result in the immune-mediated inhibition of tumor cell proliferation, which leads to tumor cell death."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0000694", "l": "R3 photoreceptor cell", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C4329516", "l": "CD8+NKG2D+ AKT Cell", "d": []}, {"i": "NCIT:C132027", "l": "CD8+NKG2D+ AKT Cell", "d": ["A preparation of human CD8-positive tumor-specific T-lymphocytes engineered to express the natural killer cell activating receptor group 2D (NKG2D) and the serine/threonine kinase AKT, with potential immunomodulating and antineoplastic activities. Upon administration of CD8+NKG2D+ AKT cells, these cells target and kill tumor cells. AKT-mediated signaling enhances the activation, differentiation, proliferation and cytokine production of tumor specific T-cells, which enhances their anti-tumor effects; AKT activity in T-cells is often downregulated in the tumor environment. NKG2D, a stimulatory lymphocyte receptor, mediates the recognition of tumors cells and promotes T-cell activation and T-cell-mediated tumor cell killing; NKG2D ligands are expressed on cancer cells, while they are minimally expressed by or absent from normal, healthy cells."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002667", "l": "type 5 otic fibrocyte", "d": ["An otic fibrocyte that resides above the stria vasularis and is part of a mesenchymal gap junction network that regulates ionic homeostasis of the endolymph."]}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "UMLS:C1522059", "l": "Balloon Nevus Cell", "d": []}, {"i": "NCIT:C36863", "l": "Balloon Nevus Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0000142", "l": "hyalocyte", "d": ["A cell occurring in the peripheral part of the vitreous body of the eye that may be responsible for production of hyaluronic acid and collagen."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4758096", "l": "Entire G cell of digestive tract", "d": []}, {"i": "SNOMEDCT:781207006", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5163732", "l": "Erythrocytes | XXX | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "ic": "74.240948556675605", "identifiers": [{"i": "CL:0000980", "l": "plasmablast", "d": ["An activated mature (naive or memory) B cell that is secreting immunoglobulin, typified by being CD27-positive, CD38-positive, CD138-negative."]}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "UMLS:C1881550", "l": "Malignant Epithelial Medium-Sized Polygonal Cell", "d": []}, {"i": "NCIT:C61002", "l": "Malignant Epithelial Medium-Sized Polygonal Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "92.728541327098611", "identifiers": [{"i": "CL:0000968", "l": "Be cell", "d": ["A mature B cell that produces cytokines that can influence CD4 T cell differentiation."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1624741", "l": "Cells.CD3+CD16+CD56+", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5708043", "l": "Anti-GD2/Anti-CD70 4SCAR-expressing Bispecific T-cells", "d": []}, {"i": "NCIT:C188804", "d": []}]}
{"type": "biolink:Cell", "ic": "69.010064724098413", "identifiers": [{"i": "UMLS:C1513989", "l": "Neoplastic Immunoblast", "d": []}, {"i": "NCIT:C37009", "l": "Neoplastic Immunoblast", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5178303", "l": "Promonocytes/100 leukocytes | Blood | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "ic": "65.592359821609847", "identifiers": [{"i": "UMLS:C1519839", "l": "Urothelial Cell", "d": []}, {"i": "NCIT:C33841", "l": "Urothelial Cell", "d": ["A cell found in the layer of transitional epithelium in the wall of the bladder, ureter, and renal pelvis, external to the lamina propria."]}]}
{"type": "biolink:Cell", "ic": "73.011730055819953", "identifiers": [{"i": "CL:0008009", "l": "transversely striated visceral muscle cell", "d": ["A visceral muscle that is transversely striated.  Examples include the visceral muscle cells of arthropods."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4267709", "l": "100 Cells.CD3+CD4+", "d": []}]}
{"type": "biolink:Cell", "ic": "79.246894609297499", "identifiers": [{"i": "CL:0000836", "l": "promyelocyte", "d": ["A precursor in the granulocytic series, being a cell intermediate in development between a myeloblast and myelocyte, that has distinct nucleoli, a nuclear-to-cytoplasmic ratio of 5:1 to 3:1, and containing a few primary cytoplasmic granules. Markers for this cell are fucosyltransferase FUT4-positive, CD33-positive, integrin alpha-M-negative, low affinity immunoglobulin gamma Fc region receptor III-negative, and CD24-negative."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1267804", "l": "GPA+ lymphocyte", "d": []}, {"i": "SNOMEDCT:117508007", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4696632", "l": "Cells.CD3-CD45+", "d": []}]}
{"type": "biolink:Cell", "ic": "77.271239091128209", "identifiers": [{"i": "UMLS:C1522040", "l": "Signet Ring Adenocarcinoma Cell", "d": []}, {"i": "NCIT:C36777", "l": "Signet Ring Adenocarcinoma Cell", "d": ["A malignant glandular cell containing cytoplasmic mucin. The presence of mucin pushes the nucleus of the cell to the periphery, assuming a configuration resembling a signet ring."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5216316", "l": "Promyelocytes|NCnc|Pt|Bld", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C4764291", "l": "CRISPR-Cas9-mediated PD-1 and TCR Gene-deleted Anti-mesothelin CAR T-cells", "d": []}, {"i": "NCIT:C158606", "l": "CRISPR-Cas9-mediated PD-1 and TCR Gene-deleted Anti-mesothelin CAR T-cells", "d": ["A preparation of human T-lymphocytes transduced with a chimeric antigen receptor (CAR) specific for the tumor-associated antigen (TAA) mesothelin and gene-edited with the clustered regularly interspaced short palindromic repeats (CRISPR)-Cas9 nuclease complex to eliminate endogenous TCR and programmed death 1 (PD-1; PDCD1; CD279; programmed cell death-1) expression, with potential immunostimulating and antineoplastic activities. The CRISPR guide RNA (gRNA) specifically targets and binds to complementary sites on TCRalpha, TCRbeta and PD-1. In turn, Cas9 cleaves these specific DNA sites, thereby disrupting transcription. Upon isolation, transduction, electroporation with TCRalpha, TCRbeta and PD-1 gRNAs, which are complexed to Cas9 RNA to disrupt expression of endogenous TCRalpha, TCRbeta and PD-1, expansion ex vivo, and introduction into the patient, the CRISPR-Cas9-mediated PD-1 and TCR gene-deleted anti-mesothelin CAR T-cells recognize and bind to mesothelin-overexpressing tumor cells. This may result in a specific cytotoxic T-lymphocyte (CTL)-mediated killing of mesothelin-positive tumor cells. PD-1, an immune checkpoint receptor expressed on T-cells, plays a key role in tumor immune evasion by binding to its ligand programmed death ligand 1 (PD-L1; cluster of differentiation 274; CD274; programmed cell death-1 ligand 1) expressed on tumor cells. By removing PD-1 from T-cells, PD-1-mediated signaling is halted which may decrease T-cell exhaustion and may enhance T-cell activity against the mesothelin-expressing tumor cells. Removal of endogenous TCR reduces TCR competition for expression, increases the persistence and function of the expressed transgenic TCR, enhances resistance to T-cell exhaustion and increases T-cell activity. Mesothelin is upregulated on a variety of tumor cell types."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4510910", "l": "Blast cell positive for CD30 antigen", "d": []}, {"i": "SNOMEDCT:725172005", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2338514", "l": "Set of Ch3 cholinergic cells", "d": []}]}
{"type": "biolink:Cell", "ic": "88.140761698499901", "identifiers": [{"i": "CL:0000422", "l": "mitogenic signaling cell", "d": ["A cell whose primary function is to cause growth by stimulating cell division in its immediate cellular environment."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0000934", "l": "CD4-positive, alpha-beta cytotoxic T cell", "d": ["A CD4-positive, alpha-beta T cell that has cytotoxic function."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1179554", "l": "Pancreatic ductal cell", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5401424", "l": "Innate Lymphoid Cell", "d": []}, {"i": "NCIT:C171057", "l": "Innate Lymphoid Cell", "d": ["Innate immune cells in the lymphoid lineage that do not express recombination-activating genes (RAGs), T-cell or B-cell receptors, or any myeloid or dendritic cell markers. There are several subtypes of innate lymphoid cells (ILC): group 1 ILC express TBX21 and Th1 cytokines, group 2 ILC produce type 2 cytokines, group 3 ILC produce interleukin-17A (IL-17A) and/or IL-22 and lymphoid tissue inducer cells (LTi cells) do not express CD3 but do express IL-7, CD45, CD4 and a large number of additional markers."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C0029048", "l": "Oogonia", "d": []}, {"i": "NCIT:C12600", "l": "Primary Oocyte", "d": ["An oocyte that is arrested in the diplotene stage of meiosis prophase 1."]}, {"i": "MESH:D009867", "l": "Oogonia", "d": []}, {"i": "SNOMEDCT:78829006", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4304490", "l": "Population of all blast cells in portion of fluid", "d": []}, {"i": "SNOMEDCT:719698008", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1516092", "l": "Atypical Endothelial Cell", "d": []}, {"i": "NCIT:C37087", "l": "Atypical Endothelial Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1511462", "l": "CY10", "d": []}, {"i": "NCIT:C20245", "l": "CY10", "d": ["Provider: CyThera, Inc., San Diego, CA. No information from provider. This cell line meets the criteria for the use of human embryonic stem cells by federally funded researchers."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2326632", "l": "Fibroblast of connective tissue of prostate", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2709167", "l": "Plateletpheresis half units", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1267836", "l": "Lymphocyte positive for both CD3 antigen and IL2R1 antigen", "d": []}, {"i": "SNOMEDCT:117526005", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0946499", "l": "Cells.CD4+CD29+", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0007013", "l": "terminally differentiated odontoblast", "d": ["Odontoblast that is terminally differentiated and derived from an odontogenic papilla and associated with dentine."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C3534455", "l": "Anucleated bodies", "d": []}]}
{"type": "biolink:Cell", "ic": "71.88020023694385", "identifiers": [{"i": "CL:0000339", "l": "glioblast (sensu Vertebrata)", "d": ["An early neural cell developing from the early ependymal cell of the neural tube."]}]}
{"type": "biolink:Cell", "ic": "75.105493098994543", "identifiers": [{"i": "UMLS:C1708918", "l": "Malignant Squamoid Cell", "d": []}, {"i": "NCIT:C47808", "l": "Malignant Squamoid Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5237484", "l": "Anti-B7-H3 CAR T-cells", "d": []}, {"i": "NCIT:C165844", "l": "Anti-B7-H3 CAR T-cells", "d": ["A preparation of T-lymphocytes that have been genetically modified to express a chimeric antigen receptor (CAR) targeting the immunoregulatory protein B7-homologue 3 (B7-H3, CD276) and containing, as of yet undisclosed co-stimulatory signaling domains, with potential immunostimulating and antineoplastic activities. Upon administration, anti-B7-H3 CAR T-cells target and bind to B7-H3-expressing tumor cells, thereby inducing selective toxicity in B7-H3-expressing tumor cells. B7-H3, a type I transmembrane protein and a member of the B7 co-stimulatory protein superfamily, is overexpressed on certain tumor cell types and on various immune cells. It is a negative regulator of the T-cell activation and its overexpression plays a key role in tumor cell invasion and metastasis."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0333765", "l": "Target fibers", "d": []}, {"i": "SNOMEDCT:39037003", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0009019", "l": "nephrogenic zone cell", "d": ["A kidney cortical cell that is part of the nephrogenic zone."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1182789", "l": "Epithelial cell of visceral layer of glomerular capsule", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C4724877", "l": "Autologous Anti-BCMA-CAR-4-1BB-CD3zeta-EGFRt-expressing CD4+/CD8+ T-lymphocytes", "d": []}, {"i": "NCIT:C148177", "l": "Autologous Anti-BCMA-CAR-4-1BB-CD3zeta-EGFRt-expressing CD4+/CD8+ T-lymphocytes", "d": ["A preparation of an approximately equal ratio of autologous CD4- and CD8-positive T-lymphocytes that have been ex vivo transduced with a genetically-engineered self-inactivating (SIN) lentiviral vector (LV) expressing a chimeric antigen receptor (CAR) containing a single chain variable fragment (scFv) specific for the human tumor-associated antigen (TAA) B-cell maturation antigen (BCMA; tumor necrosis factor receptor superfamily member 17; TNFRSF17) fused to the co-stimulatory domain of 4-1BB (CD137), the CD3-zeta (CD3z) T-cell signaling domain, and a truncated form of the human epidermal growth factor receptor (EGFRt), with potential immunostimulating and antineoplastic activities. Upon administration, the autologous anti-BCMA-CAR-4-1BB-CD3zeta-EGFRt-expressing CD4+/CD8+ T-lymphocytes specifically recognize and induce selective toxicity against BCMA-expressing tumor cells. Devoid of both ligand binding domains and tyrosine kinase activity, the expressed EGFRt facilitates both in vivo detection of the administered, transduced T-cells and can promote elimination of those cells through a cetuximab-induced antibody-dependent cellular cytotoxicity (ADCC) response. BCMA, a tumor-specific antigen and a receptor for both a proliferation-inducing ligand (APRIL) and B-cell activating factor (BAFF), is a member of the tumor necrosis factor receptor superfamily (TNFRSF) and plays a key role in plasma cell survival. BCMA is found on the surfaces of plasma cells and is overexpressed on malignant plasma cells."]}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "UMLS:C1709163", "l": "Neoplastic Adrenal Cortical Oncocyte", "d": []}, {"i": "NCIT:C48448", "l": "Neoplastic Adrenal Cortical Oncocyte", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2328956", "l": "Set of cholinergic cells of dorsal tegmental area [Ch5]", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5555879", "l": "Autologous Anti-CD19 CAR-4-1BB-CD3zeta-expressing T-cells ARI-0001", "d": []}, {"i": "NCIT:C179725", "l": "Autologous Anti-CD19 CAR-4-1BB-CD3zeta-expressing T-cells ARI-0001", "d": ["A preparation of adult differentiated autologous T-lymphocytes that have been transduced with a lentiviral vector expressing a chimeric antigen receptor (CAR) composed of an anti-cluster of differentiation 19 (CD19) single chain variable fragment (scFv), derived from the CD19-A3B1 hybridoma, linked to the intracellular signaling domains of 4-1BB (CD137) and the zeta chain of the TCR/CD3 complex (TCRzeta; CD247; CD3zeta), with potential immunomodulating and antineoplastic activities. The autologous T cells were stimulated with anti-CD3 and anti-CD28 antibodies, expanded with interleukin (IL) 7 (IL-7) and IL-15, and transduced with a lentiviral vector containing the CAR gene construct. Upon administration, autologous anti-CD19 CAR-4-1BB-CD3zeta-expressing T-cells ARI-0001 target, bind to and induce selective toxicity in CD19-expressing tumor cells. CD19 antigen is a B-cell specific cell surface antigen expressed in all B-cell lineage malignancies."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0000590", "l": "small luteal cell", "d": ["A progesterone secreting cell in the corpus luteum that develops from theca cells."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5700416", "l": "Autologous Anti-mesothelin T-cell Receptor Fusion Construct T-cells TC-210", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4300409", "l": "Cells.CD3+CD8+CD45RO+", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0000902", "l": "induced T-regulatory cell", "d": ["CD4-positive alpha-beta T cell with the phenotype CD25-positive, CTLA-4-positive, and FoxP3-positive with regulatory function."]}]}
{"type": "biolink:Cell", "ic": "84.75972595860604", "identifiers": [{"i": "CL:0002169", "l": "basal cell of olfactory epithelium", "d": ["An epithelial cell located on the basal lamina of the olfactory epithelium."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0000760", "l": "type 8 cone bipolar cell (sensu Mus)", "d": ["An ON-bipolar neuron found in the retina and having connections with cone photoreceptors cells and neurons in the inner half of the inner plexiform layer. This cell has the widest dendritic field and the widest axon terminal of all retinal bipolar cells. The axon terminal is delicate and stratified through sublaminae 4 and 5 of the inner plexiform layer."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5554960", "l": "Anti-Claudin18.2 CAR T Cells LCAR-C18S", "d": []}, {"i": "NCIT:C178335", "l": "Anti-Claudin18.2 CAR T Cells LCAR-C18S", "d": ["A preparation of T-lymphocytes engineered to express a chimeric antigen receptor (CAR) specific for the tumor-associated antigen (TAA) Claudin18.2 (CLDN18.2; A2 isoform of claudin-18), with potential immunostimulating and antineoplastic activities. Upon administration, anti-Claudin18.2 CAR T cells LCAR-C18S specifically recognize and induce selective toxicity in CLDN18.2-expressing tumor cells. CLDN18.2, a tight junction protein, is expressed on a variety of tumor cells, but its expression in healthy tissues is strictly confined to short-lived differentiated epithelial cells of the gastric mucosa."]}]}
{"type": "biolink:Cell", "ic": "83.552982069901191", "identifiers": [{"i": "UMLS:C0814999", "l": "thymocyte", "d": []}, {"i": "NCIT:C12994", "l": "Thymocyte", "d": ["A cell that develops in the thymus, seemingly from a stem cell of bone marrow and of fetal liver, and is the precursor of the thymus-derived lymphocyte (T lymphocyte) that effects cell-mediated (delayed type) sensitivity."]}, {"i": "MESH:D060168", "l": "Thymocytes", "d": []}, {"i": "SNOMEDCT:39105001", "d": []}]}
{"type": "biolink:Cell", "ic": "84.128890093485552", "identifiers": [{"i": "CL:0000606", "l": "macroconidium", "d": ["The larger of two types of asexual spores formed by some fungi; usually round or oblong."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0808143", "l": "Synovial lining cells", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1267858", "l": "Lymphocyte positive for both CD8 antigen and CD57 antigen", "d": []}, {"i": "SNOMEDCT:117541005", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0000655", "l": "secondary oocyte", "d": ["A secondary oocyte is an oocyte that has not completed meiosis II."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157512", "l": "CD38+ Lambda+ cells | Blood | Cell markers", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0000345", "l": "dental papilla cell", "d": ["A mesenchymal cell that is part of a small mass of condensed mesenchyme in the enamel organ; it differentiates into the dentin and dental pulp."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157524", "l": "CD3-CD45+ cells | Blood | Cell markers", "d": []}]}
{"type": "biolink:Cell", "ic": "92.728541327098611", "identifiers": [{"i": "CL:0002657", "l": "glandular cell of esophagus", "d": ["A glandular epithelial cell of the esophagus."]}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "UMLS:C1711394", "l": "Neoplastic Thyroid Gland Follicular Cell with Large and Hyperchromatic Nucleus", "d": []}, {"i": "NCIT:C47833", "l": "Neoplastic Thyroid Gland Follicular Cell with Large and Hyperchromatic Nucleus", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4253014", "l": "Set of enteroendocrine cells of epithelium of small intestine", "d": []}]}
{"type": "biolink:Cell", "ic": "89.347505587204751", "identifiers": [{"i": "UMLS:C1707937", "l": "Epithelial Stem Cell", "d": []}, {"i": "NCIT:C43422", "l": "Epithelial Stem Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "75.751739371353352", "identifiers": [{"i": "CL:2000074", "l": "splenocyte", "d": ["Any leukocyte that is part of a spleen."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002238", "l": "male gonocyte", "d": ["A primordial germ cell that is destined to become a male germ cell."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5177474", "l": "Plasma cells/100 leukocytes | Pericardial fluid | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "ic": "63.349675134728187", "identifiers": [{"i": "CL:0002251", "l": "epithelial cell of alimentary canal", "d": ["An epithelial cell of the musculomembranous digestive tube extending from the mouth to the anus."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157500", "l": "CD34+DR+ | White blood cells | Cell markers", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1440312", "l": "Cells.CD44", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5166478", "l": "Helmet cells | Blood | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5173415", "l": "Monoblasts | Blood | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5216197", "l": "Blasts|NCnc|Pt|Body fld", "d": []}]}
{"type": "biolink:Cell", "ic": "49.337024390265185", "identifiers": [{"i": "UMLS:C1513026", "l": "Mature Lymphocyte", "d": []}, {"i": "NCIT:C38439", "l": "Mature Lymphocyte", "d": ["A white blood cell that matures in the primary lymphoid organs and then circulates through the lymph system to the secondary lymphoid tissues where it interacts with antigens. A mature lymphocyte varies in size from 7 to 15 micrometer in diameter and is round or ovoid, but may be notched or slightly indented. The chromatin is generally diffusely dense and nucleoli are not usually visible."]}]}
{"type": "biolink:Cell", "ic": "84.128890093485552", "identifiers": [{"i": "CL:4023057", "l": "cerebellar inhibitory GABAergic interneuron", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5173470", "l": "Monocytes+Macrophages | Peritoneal fluid | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5706499", "l": "Trained Immunity Natural Killer Cells IBR900", "d": []}, {"i": "NCIT:C188374", "d": []}]}
{"type": "biolink:Cell", "ic": "90.82444074280258", "identifiers": [{"i": "CL:0009021", "l": "stromal cell of lamina propria of large intestine", "d": ["A stromal cell found in the lamina propria of the large intestine."]}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "UMLS:C0008572", "l": "Chromatophore", "d": []}, {"i": "NCIT:C12581", "l": "Chromatophore", "d": ["A pigment-producing cell located in the deeper layers of the skin."]}, {"i": "MESH:D002856", "l": "Chromatophores", "d": []}]}
{"type": "biolink:Cell", "ic": "80.869303025598512", "identifiers": [{"i": "CL:1000893", "l": "kidney venous blood vessel cell", "d": []}]}
{"type": "biolink:Cell", "ic": "86.236661114203869", "identifiers": [{"i": "UMLS:C1510720", "l": "Abnormal Eosinophil", "d": []}, {"i": "NCIT:C37032", "l": "Abnormal Eosinophil", "d": []}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "CL:0000358", "l": "sphincter associated smooth muscle cell", "d": ["A smooth muscle cell that is part of a sphincter. A sphincter is a typically circular muscle that normally maintains constriction of a natural body passage or orifice and which relaxes as required by normal physiological functioning."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0004221", "l": "flag A amacrine cell", "d": ["A flag amacrine cell with post-synaptic terminals in S2 and S3. This cell type releases the neurotransmitter glycine."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1182651", "l": "Smooth muscle fiber of sphincter of pupil", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1440335", "l": "Cells.CD59 deficient", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C2981784", "l": "WT1 mRNA-Electroporated Autologous Dendritic Cell Vaccine", "d": []}, {"i": "NCIT:C88260", "l": "WT1 mRNA-Electroporated Autologous Dendritic Cell Vaccine", "d": ["A cancer vaccine containing autologous dendritic cells electroporated with full-length mRNA encoding Wilms' tumor 1 (WT1) antigen with potential immunostimulatory and antineoplastic activities. Upon administration, WT1 mRNA-electroporated autologous dendritic cell vaccine may elicit a cytotoxic T-cell (CTL) response against tumor cells expressing WT1. Wt1 is frequently overexpressed in a variety of tumor cell types and often correlates with disease progression and poor prognosis."]}]}
{"type": "biolink:Cell", "ic": "67.7322052342289", "identifiers": [{"i": "CL:0002584", "l": "renal cortical epithelial cell", "d": ["An epithelial cell of the kidney cortex."]}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "UMLS:C1708885", "l": "Malignant Lactotroph Cell", "d": []}, {"i": "NCIT:C45951", "l": "Malignant Lactotroph Cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2950850", "l": "Type D cell of small intestine", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C0229470", "l": "Pillar cell", "d": []}, {"i": "NCIT:C33322", "l": "Pillar Cell", "d": ["A flattened cell that rests on the tympanic lip of the spiral lamina (inner pillar cell) and on the basilar membrane (outer pillar cell), thereby forming the tunnel of the Organ of Corti."]}, {"i": "SNOMEDCT:55842008", "d": []}]}
{"type": "biolink:Cell", "ic": "77.944915021140389", "identifiers": [{"i": "UMLS:C1709196", "l": "Neoplastic Retinal Ganglion Cell", "d": []}, {"i": "NCIT:C42604", "l": "Neoplastic Retinal Ganglion Cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1440266", "l": "Cells.CD19+CD38+", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002311", "l": "mammotroph", "d": ["An acidophilic cell of the anterior pituitary that produces prolactin."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5170957", "l": "Leukocytes other | Pleural fluid | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5216259", "l": "Malignant cells|NCnc|Pt|Bld", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C0314593", "l": "Colony-forming unit of megakarocytic lineage", "d": []}, {"i": "NCIT:C121478", "l": "Megakaryocyte Colony Forming Unit", "d": ["A unit of viable cell concentration defined as the minimum number of hematopoietic stem cells able to produce a detectable colony of megakaryocyte lineage cells."]}, {"i": "SNOMEDCT:445093009", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002627", "l": "mature astrocyte", "d": ["A mature astrocyte that is capable of producing cytokines."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5690733", "l": "M Cells, Bronchiolar", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5761741", "l": "P140K methylguanine-DNA-methyltransferase mutant CD34+ cells", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5155167", "l": "Blasts | Body fluid | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "ic": "80.869303025598512", "identifiers": [{"i": "UMLS:C1881357", "l": "Large Adenocarcinoma Cell with Eosinophilic Cytoplasm", "d": []}, {"i": "NCIT:C61110", "l": "Large Adenocarcinoma Cell with Eosinophilic Cytoplasm", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C4054455", "l": "Multinucleated Hepatocyte", "d": []}, {"i": "NCIT:C120900", "l": "Multinucleated Hepatocyte", "d": ["A giant hepatocyte with multiple nuclei."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5171658", "l": "Lymphocytes | Blood cord | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1440240", "l": "Cells.CD107b", "d": []}]}
{"type": "biolink:Cell", "ic": "69.653168928076894", "identifiers": [{"i": "CL:0000202", "l": "auditory hair cell", "d": ["A mechanoreceptor cell of the auditory or vestibular system that is sensitive to auditory stimuli. The accessory sensory structures are arranged so that appropriate stimuli cause movement of the hair-like projections (stereocilia and kinocilia) which relay the information centrally in the nervous system."]}]}
{"type": "biolink:Cell", "ic": "82.076046914303362", "identifiers": [{"i": "CL:1000616", "l": "kidney outer medulla cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1317328", "l": "Immature eosinophils", "d": []}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "UMLS:C1518173", "l": "Malignant Eosinophilic Cell Oncocyte", "d": []}, {"i": "NCIT:C37167", "l": "Malignant Eosinophilic Cell Oncocyte", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1511465", "l": "CY40", "d": []}, {"i": "NCIT:C20239", "l": "CY40", "d": ["Provider: CyThera, Inc., San Diego, CA. No information from provider. This cell line meets the criteria for the use of human embryonic stem cells by federally funded researchers."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0598829", "l": "Madin Darby Canine Kidney Cells", "d": []}, {"i": "MESH:D061985", "l": "Madin Darby Canine Kidney Cells", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1440356", "l": "Cells.CD79b", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5163453", "l": "Eosinophils.immature/100 leukocytes | Blood | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "ic": "67.152088137740293", "identifiers": [{"i": "UMLS:C1514056", "l": "Neoplastic Perineural Cell", "d": []}, {"i": "NCIT:C41413", "l": "Neoplastic Perineural Cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4726587", "l": "Donor-derived CD34+ HPCs/CD3+ T-cells MDR-101", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5708807", "l": "Sphere Vitreous Seed", "d": []}, {"i": "NCIT:C189883", "d": []}]}
{"type": "biolink:Cell", "ic": "92.728541327098611", "identifiers": [{"i": "CL:0003005", "l": "G4 retinal ganglion cell", "d": ["A mono-stratified retinal ganglion cell that has a small dendritic field and dense dendritic arbor."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0011030", "l": "dermal microvascular endothelial cell", "d": ["Any microvascular endothelial cell that is part of the dermis."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5205487", "l": "Autologous Anti-CS1 Hinge-optimized CAR-4-1BB-EGFRt-expressing Memory-enriched T-cells", "d": []}, {"i": "NCIT:C160711", "l": "Autologous Anti-CS1 Hinge-optimized CAR-4-1BB-EGFRt-expressing Memory-enriched T-cells", "d": ["A preparation of autologous central memory-enriched T-cells (Tcm) that have been transduced with a self-inactivating (SIN) lentiviral vector expressing a hinge-optimized chimeric antigen receptor (CAR) comprised of a CS1 (CD2 subset 1; SLAM family member 7; SLAMF7; CD319; CRACC)-specific single chain variable fragment (scFV), fused to the costimulatory signaling domain of 4-1BB (CD137), and a truncated human epidermal growth factor receptor (huEGFRt), with potential antineoplastic activity. Upon intravenous infusion, anti-CS1-CAR-4-1BB-CD3z-EGFRt-expressing Tcm-enriched T-lymphocytes target and induce selective toxicity in CS-1-expressing tumor cells. Devoid of both ligand binding domains and tyrosine kinase activity, the expressed huEGFRt facilitates both in vivo detection of the administered, transduced T-cells and can promote elimination of those cells through a cetuximab-induced antibody-dependent cellular cytotoxicity (ADCC) response. CS1, a cell surface glycoprotein of the signaling lymphocyte activation molecule (SLAM) receptor family, is highly expressed on certain malignant plasma cells."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2599784", "l": "Granulocytes.CD55 deficient", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5177454", "l": "Plasma cells | Body fluid | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5170928", "l": "Leukocytes | Ear | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0000708", "l": "leptomeningeal cell", "d": ["Stromal cell that forms the internal covering of the vertebrate brain and produces ECM for this and the choroid plexus."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4518146", "l": "Population of all spermatozoa with double forms in portion of fluid", "d": []}, {"i": "SNOMEDCT:725251004", "d": []}]}
{"type": "biolink:Cell", "ic": "70.071335352100078", "identifiers": [{"i": "CL:0002425", "l": "early T lineage precursor", "d": ["A pro-T cell that is lin-negative, CD25-negative, CD127-negative, CD44-positive and kit-positive."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0228088", "l": "Bergmann Glia", "d": []}, {"i": "SNOMEDCT:55306009", "d": []}]}
{"type": "biolink:Cell", "ic": "86.236661114203869", "identifiers": [{"i": "UMLS:C1883279", "l": "Terminal Duct Cell", "d": []}, {"i": "NCIT:C62170", "l": "Terminal Duct Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002589", "l": "smooth muscle cell of the brachiocephalic vasculature", "d": ["A smooth muscle cell of the bachiocephalic vasculature."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1440236", "l": "Cell positive for CD104 antigen", "d": []}, {"i": "SNOMEDCT:725329009", "d": []}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "CL:0000848", "l": "microvillous olfactory receptor neuron", "d": ["An olfactory receptor cell in which the apical ending of the dendrite is a knob that bears numerous microvilli."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1512446", "l": "High Grade Malignant Transitional Cell", "d": []}, {"i": "NCIT:C36838", "l": "High Grade Malignant Transitional Cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157436", "l": "CD3+CD4+ (T4 helper) cells | Bone marrow | Cell markers", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002586", "l": "retinal pigment epithelial cell", "d": ["An epithelial cell of the retinal pigmented epithelium."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157533", "l": "CD4 cells | XXX | Cell markers", "d": []}]}
{"type": "biolink:Cell", "ic": "69.32380909477429", "identifiers": [{"i": "CL:0002194", "l": "monopoietic cell", "d": ["A cell involved in the formation of a monocyte (monopoiesis)."]}]}
{"type": "biolink:Cell", "ic": "90.82444074280258", "identifiers": [{"i": "UMLS:C0023602", "l": "Structure of interstitial cell of Leydig", "d": []}, {"i": "NCIT:C12609", "l": "Leydig Cell", "d": ["Testosterone-secreting interstitial cells located between the seminiferous tubules of the testes."]}, {"i": "MESH:D007985", "l": "Leydig Cells", "d": []}, {"i": "SNOMEDCT:44185004", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2736937", "l": "Cells.CD8+CD45RA+", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5417820", "l": "Allogeneic CD8+ Leukemia-associated Antigens Specific T Cells NEXI-001", "d": []}, {"i": "NCIT:C170887", "l": "Allogeneic CD8+ Leukemia-associated Antigens Specific T Cells NEXI-001", "d": ["A preparation of allogeneic CD8+ T cells targeting multiple undisclosed leukemia-associated antigens, with potential immunomodulating and antineoplastic activities. Following peripheral blood mononuclear cell (PBMC) collection from the original stem cell donor and ex vivo priming and expansion, the allogeneic CD8+ leukemia-associated antigens specific T cells NEXI-001 are re-introduced into the leukemia patient, where they target and kill tumor cells expressing these leukemia-associated antigens."]}]}
{"type": "biolink:Cell", "ic": "75.42073205405498", "identifiers": [{"i": "UMLS:C1513947", "l": "Neoplastic Cytotrophoblastic Cell", "d": []}, {"i": "NCIT:C37140", "l": "Neoplastic Cytotrophoblastic Cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2331651", "l": "Polar Bodies", "d": []}, {"i": "MESH:D059705", "l": "Polar Bodies", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002467", "l": "Gr1-high myeloid suppressor cell", "d": ["A myeloid suppressor cell that is Gr1-high and CD11c-negative."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5691291", "l": "Peyer's Patch M Cells", "d": []}]}
{"type": "biolink:Cell", "ic": "80.17194633000733", "identifiers": [{"i": "UMLS:C1513966", "l": "Neoplastic Fibroblast-Like Cell", "d": []}, {"i": "NCIT:C36959", "l": "Neoplastic Fibroblast-Like Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "92.728541327098611", "identifiers": [{"i": "UMLS:C0021792", "l": "Interneurons", "d": []}, {"i": "NCIT:C12625", "l": "Interneuron", "d": ["A type of neuron in the central nervous system that conducts impulses between other neurons."]}, {"i": "MESH:D007395", "l": "Interneurons", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1515628", "l": "gp100-Pulsed Peripheral Blood Mononuclear Cell", "d": []}, {"i": "NCIT:C2762", "l": "gp100-Pulsed Peripheral Blood Mononuclear Cell", "d": ["Peripheral blood lymphocytes (PBL) harvested from host blood and stimulated in vitro with tumor-specific gp 100 antigen. 'Pulsing' PBL with gp100, a tumor associated antigen (TAA) commonly expressed by melanoma cells, may increase melanoma-reactive cytotoxic lymphocytes (CTL) in the PBL cell population. Autologous gp100-pulsed PBL have been administered to melanoma patients in order to augment cytotoxic immune responses to melanoma.  (NCI04)"]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4733830", "l": "Fibroblasts (Human)", "d": []}]}
{"type": "biolink:Cell", "ic": "90.82444074280258", "identifiers": [{"i": "CL:1000082", "l": "stretch receptor cell", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002617", "l": "adipocyte of breast", "d": ["A fat cell that is part of the breast."]}]}
{"type": "biolink:Cell", "ic": "92.728541327098611", "identifiers": [{"i": "CL:0003036", "l": "M7 retinal ganglion cell", "d": ["A monostratified retinal ganglion cell with large soma and large dendritic field, with medium dendritic arbor, and has dendrites in layers 2 and 5."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1440284", "l": "Cells.CD3+CD4+CD45RO-CD45RA+", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C3850017", "l": "Endothelial Progenitor Cells", "d": []}, {"i": "NCIT:C124145", "l": "Endothelial Progenitor Cell", "d": ["Circulating cells that express a variety of cell surface markers similar to those expressed by vascular endothelial cells, adhere to endothelium at sites of hypoxia or ischemia, and participate in new vessel formation."]}, {"i": "MESH:D066026", "l": "Endothelial Progenitor Cells", "d": []}]}
{"type": "biolink:Cell", "ic": "92.728541327098611", "identifiers": [{"i": "CL:0000508", "l": "type G enteroendocrine cell", "d": ["An endocrine cell found in the pyloric gland mucosa (antral mucosa) of the stomach of mammals and responsible for the secretion of gastrin and enkephalin. Most abundant in pyloric antrum, pyramidal in form with a narrow apex bearing long microvilli."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5177624", "l": "Platelets agranular | Blood | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157361", "l": "CD19+Lambda+ cells | Blood | Cell markers", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2335233", "l": "Basal cell of epithelium of respiratory bronchiole", "d": []}]}
{"type": "biolink:Cell", "ic": "83.552982069901191", "identifiers": [{"i": "UMLS:C1709169", "l": "Neoplastic Connective and Soft Tissue Epithelioid Cell", "d": []}, {"i": "NCIT:C43307", "l": "Neoplastic Connective and Soft Tissue Epithelioid Cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C3282453", "l": "human cord blood hematopoietic progenitor cell", "d": []}]}
{"type": "biolink:Cell", "ic": "87.120474278337809", "identifiers": [{"i": "CL:1001052", "l": "kidney cortex vein cell", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002217", "l": "intermediate trophoblast cell", "d": ["A trophoblast that leaves the placenta and invades the endometrium and myometrium. This cell type is crucial in increasing blood flow to the fetus."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2335490", "l": "Cranial parasympathetic ganglion neuron", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C0229586", "l": "Structure of parathyroid chief cell", "d": []}, {"i": "NCIT:C33266", "l": "Parathyroid Gland Chief Cell", "d": ["The primary cell of the parathyroid gland. Its contains secretory granules, large Golgi complexes, and moderate numbers of mitochondria. It produces parathyroid hormone. The cells occur in sheets interspersed with areas of fatty tissue. Occasionally the cells are arranged in follicles."]}, {"i": "SNOMEDCT:49796000", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0000419", "l": "seam cell", "d": ["An epithelial fate stem cell found in flatworms."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:1000338", "l": "enterocyte of epithelium of crypt of Lieberkuhn of small intestine", "d": ["An enterocyte that is part of the epithelium of crypt of Lieberkuhn of small intestine."]}]}
{"type": "biolink:Cell", "ic": "72.473322228407739", "identifiers": [{"i": "CL:0002632", "l": "epithelial cell of lower respiratory tract", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1710678", "l": "Wolffian Duct Cell", "d": []}, {"i": "NCIT:C43425", "l": "Wolffian Duct Cell", "d": ["A cell of the embryonic mesonephric duct. This duct connects the primitive kidney and urogenital sinus. In the presence of testosterone, it develops into the sperm collecting apparatus - epididymis, the vas deferens, and seminal vesicles. Without testosterone, it becomes vestigial."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C2986394", "l": "Allogeneic Natural Killer Cell Line MG4101", "d": []}, {"i": "NCIT:C94209", "l": "Allogeneic Natural Killer Cell Line MG4101", "d": ["A population of allogeneic, cytotoxic natural killer (NK) cells with potential antitumor activity. Allogeneic natural killer cell line MG4101 is derived from cells of a normal, healthy donor upon leukapheresis and activation."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5216266", "l": "Mesothelial cells|NCnc|Pt|Synv fld", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5163729", "l": "Erythrocytes | Urine sediment | Urinalysis", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1442179", "l": "Amniotic Fluid cells", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5382753", "l": "CD18 cells | Blood | Cell markers", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4697028", "l": "Cells.CD28+HLA DR+", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0009037", "l": "lymph node mantle zone B cell", "d": ["A B lymphocyte that resides in the mantle zone of the lymph node germinal center. These are generally IgM and IgD positive activated B cells that form a 'corona' around the germinal center and are part of the establishment of a secondary lymphatic follicule."]}]}
{"type": "biolink:Cell", "ic": "92.728541327098611", "identifiers": [{"i": "UMLS:C1516470", "l": "Chief cell", "d": []}, {"i": "NCIT:C12580", "l": "Chief Cell", "d": ["One of three cell types that are found in the gastric or parathyroid glands, or in the carotid body. Gastric chief cells secrete pepsinogen and chymosin. Parathyroid chief cells secrete parathyroid hormone. Type 1 (chief) cells in the carotid body contain neurosecretory vesicles that may play a role in chemoreception."]}]}
{"type": "biolink:Cell", "ic": "90.82444074280258", "identifiers": [{"i": "UMLS:C3642320", "l": "Immature Malignant Mast Cell", "d": []}, {"i": "NCIT:C37063", "l": "Immature Malignant Mast Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0011009", "l": "embryonic plasmatocyte", "d": ["A plasmatocyte derived from the embryonic head mesoderm."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2950040", "l": "Type D cell of ileum", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5667072", "l": "Allogeneic CD16-expressing Natural Killer Cells CYNK-101", "d": []}, {"i": "NCIT:C186655", "l": "Allogeneic CD16-expressing Natural Killer Cells CYNK-101", "d": ["A population of cryopreserved, off-the-shelf (OTS) allogeneic natural killer (NK) cells derived from human placental hematopoietic stem cells (HSCs) expressing the CD34 surface antigen, and engineered to express a high-affinity, non-cleavable CD16 (hnCD16) Fc receptor, with potential antineoplastic and immunostimulatory activities. Upon infusion of CYNK-101, the allogeneic CD16-expressing NK cells bind to the Fc portion of tumor cell-bound monoclonal antibodies that were administered as induction therapy. This enhances NK cell activation, cytokine secretion, and antibody-dependent cellular cytotoxicity (ADCC) in the presence of certain antibody therapeutics. CD16, also known as Fc-gamma receptor III, is normally expressed on the surface of NK cells, neutrophils, monocytes and macrophages, and plays a key role in initiating ADCC. It is often downregulated in certain cancers, thereby inhibiting the anti-tumor immune response. CYNK-101 NK cells' hnCD16 Fc receptor prevents downregulation and optimizes binding to tumor-targeting antibodies for enhanced ADCC."]}]}
{"type": "biolink:Cell", "ic": "70.517713470395833", "identifiers": [{"i": "CL:0000864", "l": "tissue-resident macrophage", "d": ["A macrophage constitutively resident in a particular tissue under non-inflammatory conditions, and capable of phagocytosing a variety of extracellular particulate material, including immune complexes, microorganisms, and dead cells."]}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "CL:0009089", "l": "lung pericyte", "d": ["A pericyte cell that is part of a lung."]}]}
{"type": "biolink:Cell", "ic": "85.457082654197222", "identifiers": [{"i": "UMLS:C0039748", "l": "theca cell", "d": []}, {"i": "NCIT:C12572", "l": "Theca Cell", "d": ["An endocrine cell located in the ovary that functions to produce androgens for estrogen biosynthesis and provide structural support during oocyte maturation."]}, {"i": "MESH:D013799", "l": "Theca Cells", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C3496149", "l": "A17 dopamine cells", "d": []}]}
{"type": "biolink:Cell", "ic": "57.771456014425979", "identifiers": [{"i": "CL:0000057", "l": "fibroblast", "d": ["A connective tissue cell which secretes an extracellular matrix rich in collagen and other macromolecules. Flattened and irregular in outline with branching processes; appear fusiform or spindle-shaped."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C2348032", "l": "Cytokine-Induced Killer Cells", "d": []}, {"i": "NCIT:C71757", "l": "Cytokine-Induced Killer Cells", "d": ["A preparation of cytokine-induced killer (CIK) cells, with potential immunopotentiating and antineoplastic activities. CIK cells are generated from peripheral blood lymphocytes (PBLs) by sequential ex vivo incubation with a monoclonal antibody against CD3 (anti-CD3), interferon-gamma (IFN-g) and interleukin-2 (IL-2), followed by expansion. CIK cells are heterogeneous cells comprising CD3+CD56- T cells, CD3-CD56+ natural killer (NK) cells, and CD3+CD56+ natural killer T (NKT) cells. Upon administration of the CIK cells into the patient, the terminally differentiated CD3- and CD56-positive subset of the CIK cells primarily exert the direct MHC-unrestricted tumor killing activity."]}, {"i": "MESH:D055612", "l": "Cytokine-Induced Killer Cells", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5216217", "l": "Erythrocytes|NCnc|Pt|Periton fld", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0229649", "l": "Heterophil", "d": []}, {"i": "SNOMEDCT:76335007", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157522", "l": "CD3-CD16+CD56+ (Natural killer) cells | XXX | Cell markers", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1179124", "l": "Type I taste bud cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5170940", "l": "Leukocytes | Stool | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "ic": "92.728541327098611", "identifiers": [{"i": "UMLS:C0312740", "l": "Immune effector cell", "d": []}, {"i": "NCIT:C28241", "l": "Effector Immune Cell", "d": ["An immune cell, usually a T- or B- lymphocyte, that is responding to an antigen exposure."]}, {"i": "SNOMEDCT:86224008", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1979240", "l": "Blasts.CD36", "d": []}]}
{"type": "biolink:Cell", "ic": "72.900487657105927", "identifiers": [{"i": "UMLS:C0227599", "l": "Transitional epithelial cell of urinary bladder", "d": []}, {"i": "NCIT:C32210", "l": "Bladder Urothelial Cell", "d": ["An epithelial cell, found in the bladder, originally thought to represent a transitional form between stratified squamous and columnar epithelial cells.  In the contracted condition the epithelium consists of many cell layers, whereas in the stretched condition usually only two layers of cells can be distinguished."]}, {"i": "SNOMEDCT:2150006", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4322816", "l": "CD79A+ B lymphocyte", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5216319", "l": "Sezary cells|NCnc|Pt|Bld", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:1000337", "l": "enterocyte of epithelium of duodenal gland", "d": ["An enterocyte that is part of the epithelium of duodenal gland."]}]}
{"type": "biolink:Cell", "ic": "70.441195081532641", "identifiers": [{"i": "CL:0000807", "l": "DN3 thymocyte", "d": ["A thymocyte that has the phenotype CD4-negative, CD8-negative, CD44-negative, and CD25-positive and expressing the T cell receptor beta-chain in complex with the pre-T cell receptor alpha chain."]}]}
{"type": "biolink:Cell", "ic": "80.17194633000733", "identifiers": [{"i": "UMLS:C1518984", "l": "Neoplastic Perineurial-Like Cell", "d": []}, {"i": "NCIT:C37152", "l": "Neoplastic Perineurial-Like Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5418067", "l": "Autologous Anti-BCMA CAR T-cells PHE885", "d": []}, {"i": "NCIT:C174124", "l": "Autologous Anti-BCMA CAR T-cells PHE885", "d": ["A preparation of autologous T-lymphocytes that have been genetically engineered to express a chimeric antigen receptor (CAR) targeting the human tumor-associated antigen (TAA) B-cell maturation antigen (BCMA; tumor necrosis factor receptor superfamily member 17; TNFRSF17), with potential antineoplastic activity. Upon administration, the autologous anti-BCMA CAR T-cells PHE885 recognize and induce selective toxicity against BCMA-expressing tumor cells. BCMA, a tumor-specific antigen and a receptor for both a proliferation-inducing ligand (APRIL) and B-cell activating factor (BAFF), is a member of the tumor necrosis factor receptor superfamily (TNFRSF) and plays a key role in plasma cell survival. BCMA is found on the surfaces of plasma cells and is overexpressed on malignant plasma cells."]}]}
{"type": "biolink:Cell", "ic": "73.597844352697123", "identifiers": [{"i": "CL:0002067", "l": "type A enteroendocrine cell", "d": ["An enteroendocrine cell that produces glucagon."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2332839", "l": "Purkinje myocyte of interventricular septum", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C3847843", "l": "Basophil positive for CD63 antigen", "d": []}, {"i": "SNOMEDCT:724247008", "d": []}]}
{"type": "biolink:Cell", "ic": "83.023198044254755", "identifiers": [{"i": "UMLS:C1522173", "l": "CNS - Brain - Astrocyte (MMHCC)", "d": []}, {"i": "NCIT:C22607", "l": "Mouse Astrocyte", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1182776", "l": "Lens cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5155100", "l": "Bizarre cells | Blood | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5443442", "l": "lisocabtagene maraleucel, CD8 component, 1 of 2", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0545578", "l": "Marrow plasmablast", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0000662", "l": "neuroglioblast (sensu Nematoda)", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5555727", "l": "WT1/PRAME/Survivin-specific T-cells MANA-312", "d": []}, {"i": "NCIT:C179500", "l": "WT1/PRAME/Survivin-specific T-cells MANA-312", "d": ["A preparation of off-the-shelf (OTS) donor-derived T-lymphocytes that are reactive to multiple tumor-associated antigens (TAAs), with potential immunomodulating and antineoplastic activities. T-cells derived from allogeneic donor leukocytes are stimulated with monocyte-derived dendritic cells (DCs) that are pulsed with a mix of peptides derived from the three TAAs Wilms tumor 1 (WT1), preferentially expressed antigen of melanoma (PRAME; melanoma antigen preferentially expressed in tumors; Opa-interacting protein 4; OIP-4) and survivin (baculoviral IAP repeat-containing protein 5; BIRC5). The antigen-specific T-cells are subsequently expanded. Upon administration of WT1/PRAME/survivin-specific T-cells MANA 312, the T-cells recognize, induce a T-cell mediated immune response in and induce lysis of tumor cells that express WT1, PRAME and/or survivin. In addition, tumor cell lysis induces the release of a broader set of tumor antigens, thereby further stimulating the immune system to exert an anti-tumor T-cell-mediated immune response. WT1, PRAME and survivin, overexpressed in a variety of tumor cell types, play key roles in tumor cell proliferation."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C3496152", "l": "A8 dopamine cells", "d": []}]}
{"type": "biolink:Cell", "ic": "78.96520244130248", "identifiers": [{"i": "UMLS:C1513994", "l": "Neoplastic Langerhans Cell", "d": []}, {"i": "NCIT:C36889", "l": "Neoplastic Langerhans Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "92.728541327098611", "identifiers": [{"i": "CL:0000444", "l": "obliquely striated muscle cell", "d": ["A muscle cell in which the fibers are organised into sarcomeres but in which adjacent myofibrils are offset from each other, producing an oblique banding pattern."]}]}
{"type": "biolink:Cell", "ic": "56.245343708512259", "identifiers": [{"i": "UMLS:C0242629", "l": "CD8-Positive T-Lymphocytes", "d": []}, {"i": "NCIT:C12542", "l": "CD8-Positive T-Lymphocyte", "d": ["A subset of T-lymphocytes that express the CD8 surface glycoprotein and bind epitopes that are part of class I histocompatibility molecules. CD8-positive T-lymphocytes include cytotoxic T-lymphocytes and CD8+ suppressor T-lymphocytes."]}, {"i": "MESH:D018414", "l": "CD8-Positive T-Lymphocytes", "d": []}, {"i": "SNOMEDCT:117539009", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1267845", "l": "Lymphocyte positive for CD5 antigen", "d": []}, {"i": "SNOMEDCT:116854001", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5447412", "l": "IKKb-matured RNA-loaded Autologous Dendritic Cells DCIKKb", "d": []}, {"i": "NCIT:C176747", "l": "IKKb-matured RNA-loaded Autologous Dendritic Cells DCIKKb", "d": ["A cancer vaccine consisting of autologous, monocyte-derived dendritic cells (DCs) that are matured with tumor necrosis factor-alpha (TNF-alpha), interleukin-1 (IL-1) beta, IL-6, prostaglandin E2 (PGE2) and IkB kinase b (IKKb), and loaded by electroporation with autologous total tumor RNA (TTRNA), RNA coding for tumor-associated antigens (TAAs) that may include gp100, tyrosinase, PRAME, MAGE-A3 and/or IDO, and RNA coding for driver mutations that may include GNAQ/GNA11Q209, R183, SF3B1R625, CYSLTR2L129Q and/or PLCB4D630, with potential immunostimulatory and antineoplastic activities. Upon administration, IKKb-matured, RNA-loaded autologous DCs DCIKKb may elicit a highly specific cytotoxic T-lymphocyte (CTL) response against tumor cells expressing the TAAs and driver mutations encoded by the loaded RNA."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2323499", "l": "Hematopoietic cell", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5419456", "l": "Allogeneic Adipose-derived Mesenchymal Stem Cells", "d": []}, {"i": "NCIT:C172113", "l": "Allogeneic Adipose-derived Mesenchymal Stem Cells", "d": ["A preparation of culture expanded human allogeneic adipose-derived mesenchymal stem cells (MSCs), that can potentially be used to restore the function of the salivary gland tissue. Upon intra-glandular administration of the allogeneic adipose-derived MSCs, these MSCs are pluripotent and capable of differentiating into functional cells of salivary tissues. This may help heal and restore the function of these glands that are damaged by chemo- and/or radio-therapy. This may reduce symptoms of hyposalivation and xerostomia."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2717913", "l": "Telocytes", "d": []}, {"i": "MESH:D000067170", "l": "Telocytes", "d": []}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "UMLS:C5575599", "l": "Fibroblastic Reticular Cell", "d": []}, {"i": "NCIT:C13057", "l": "Fibroblastic Reticular Cell", "d": ["A cell with processes making contact with those of other similar cells to form a cellular sheath for a network of reticular fibers, which constitutes the stroma of all secondary lymphoid organs."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1527294", "l": "GE07 cell line", "d": []}, {"i": "NCIT:C20257", "l": "GE07", "d": ["Provider: Geron Corporation, Menlo Park, CA. No information from provider. This cell line meets the criteria for the use of human embryonic stem cells by federally funded researchers."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1524103", "l": "CNS - Brain - Glial Cell (MMHCC)", "d": []}, {"i": "NCIT:C22613", "l": "Mouse Glial Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0019020", "l": "extrahepatic cholangiocyte", "d": ["An epithelial cell of the extrahepatic bile ducts, including the left and right hepatic duct, common hepatic duct, and common bile duct. They are columnar in shape, and have a large nuclear-to-cytoplasmic ratio relative to small/intrahepatic cholangiocytes."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C4764038", "l": "Anti-CD38/BCMA CAR T-lymphocytes", "d": []}, {"i": "NCIT:C158087", "l": "Anti-CD38/BCMA CAR T-lymphocytes", "d": ["A preparation of T-lymphocytes that have been genetically modified to express a dual-targeted chimeric antigen receptor (CAR) recognizing the tumor-associated antigens (TAAs), cluster of differentiation 38 (CD38) and B-cell maturation antigen (BCMA; tumor necrosis factor receptor superfamily member 17; TNFRSF17), with potential immunostimulating and antineoplastic activities. Upon intravenous administration, the anti-CD38/BCMA CAR T-cells are directed to and induce selective toxicity in both CD38- and BCMA-expressing cells. CD38, a type II transmembrane glycoprotein, is present on various immune cells and hematologic malignancies, and its expression has been correlated with poor prognosis. BCMA is found on the surfaces of plasma cells and is and overexpressed on malignant plasma cells."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5170939", "l": "Leukocytes | Sputum | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:2000048", "l": "anterior horn motor neuron", "d": ["A lower motor neuron whose soma is located in the anterior horn. Anterior horn motor neurons project from the anterior portion of the grey matter in the spinal cord to some skeletal muscles."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1267889", "l": "Lymphoblast positive for CD20 antigen", "d": []}, {"i": "SNOMEDCT:117565008", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4518169", "l": "Population of all band eosinophils in portion of fluid", "d": []}, {"i": "SNOMEDCT:725233000", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1512135", "l": "ES06 (cell line)", "d": []}, {"i": "NCIT:C20254", "l": "ES06", "d": ["Provider: ES Cell International Pte Ltd., Melbourne, Australia. Information from provider and not independently verified by NIH: Undergoing characterization. This cell line meets the criteria for the use of human embryonic stem cells by federally funded researchers."]}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "CL:1000379", "l": "type 1 vestibular sensory cell of epithelium of macula of utricle of membranous labyrinth", "d": ["A type I vestibular sensory cell that is part of the epithelium of macula of utricle of membranous labyrinth."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002170", "l": "keratinized cell of the oral mucosa", "d": ["A keratinized cell located in the hard palate or gingiva."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1514656", "l": "RL10", "d": []}, {"i": "NCIT:C20290", "l": "RL10", "d": ["Provider: Reliance Life Sciences, Mumbai, India. No information from provider. This cell line meets the criteria for the use of human embryonic stem cells by federally funded researchers."]}]}
{"type": "biolink:Cell", "ic": "88.140761698499901", "identifiers": [{"i": "CL:0019001", "l": "tracheobronchial serous cell", "d": ["Any serous secreting cell that is part of the tracheobronchial epithelium."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5172359", "l": "Megakaryocytes/100 cells | Bone marrow | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:4030033", "l": "valve endothelial cell", "d": ["An endothelial cell that lines a surface of a cardiac valve leaflet. Along with valve interstitial cells, a valve endothelial cell maintains tissue homeostasis for the function of cardiac valves through secreting biochemical signals, matrix proteins and matrix remodeling enzymes."]}]}
{"type": "biolink:Cell", "ic": "77.061101857006449", "identifiers": [{"i": "CL:0000822", "l": "B-2 B cell", "d": ["A conventional B cell subject to antigenic stimulation and dependent on T cell help and with a distinct surface marker expression pattern from B-1 B cells. These cells are CD43-negative."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5216314", "l": "Prolymphocytes|NCnc|Pt|Bld", "d": []}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "UMLS:C1880084", "l": "Ciliated Adenocarcinoma Cell", "d": []}, {"i": "NCIT:C61577", "l": "Ciliated Adenocarcinoma Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C3661517", "l": "Neutrophil Band Cells", "d": []}, {"i": "NCIT:C13117", "l": "Band Cell", "d": ["A late precursor of a granulocyte in which the nucleus is in the form of a curved or coiled band, not having acquired the typical multilobar shape of the mature polymorphonuclear neutrophil."]}, {"i": "SNOMEDCT:702697008", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5557440", "l": "IGV-001", "d": []}, {"i": "NCIT:C101257", "l": "IGF-1R Antisense Oligodeoxynucleotide-treated Autologous Glioma Cells IGV-001", "d": ["A preparation of irradiated autologous glioma cells treated ex vivo with IMV-001, an antisense oligodeoxynucleotide of insulin-like growth factor receptor 1 (IGF-1R/AS ODN), and encapsulated within bio-diffusion chambers, with potential antineoplastic activity. The IGF-1R/AS ODN IMV-001-treated autologous glioma cells IGV-001 are encapsulated within implantable and removable bio-diffusion chambers with additional IMV-001, irradiated, and implanted into the patient. The IGF-1R/AS ODN binds to IGF-1R mRNA in glioma cells, and shuts down the translation of IGF-1R in the glioma cells. Downregulation of IGF-1R, in addition to irradiation, induces apoptosis and causes the release of exosomes, which contain tumor-associated antigens (TAAs). The diffusion of exosomes together with the additional IMV-001 from the bio-diffusion chambers may activate the patient's immune system and mount a cytotoxic T-lymphocyte (CTL) response against cells expressing these TAAs. IGF-1R, a receptor tyrosine kinase, is overexpressed in a variety of tumor cell types and is essential for tumor cell growth, transformation and survival."]}, {"i": "MESH:C000723383", "l": "IGV-001", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157920", "l": "Cells | Body fluid | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1518223", "l": "Malignant Neuroendocrine Small Cell with Round Nucleus", "d": []}, {"i": "NCIT:C36853", "l": "Malignant Neuroendocrine Small Cell with Round Nucleus", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1518565", "l": "Olfactory Receptor Cells", "d": []}, {"i": "NCIT:C12633", "l": "Olfactory Receptor Neuron", "d": ["A bipolar neuron located in the sensory epithelium within the nasal cavity that detects odor signal molecules and transmits olfactory information to the central nervous system."]}, {"i": "NCIT:C13151", "l": "Olfactory Receptor Cell", "d": ["A specialized, fusiform nerve cell with a large nucleus, embedded among the epithelial cells in the mucous membrane of the nose; it carries impulses from the olfactory receptors to the glomeruli in the olfactory bulb."]}, {"i": "MESH:D018034", "l": "Olfactory Receptor Neurons", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002278", "l": "GIP cell", "d": ["An enteroendocrine cell of duodenum and jejunum that produces gastric inhibitory peptide."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0682541", "l": "polyhedral cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5177459", "l": "Plasma cells monotypic population | Blood | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4764336", "l": "OmnImmune", "d": []}]}
{"type": "biolink:Cell", "ic": "92.728541327098611", "identifiers": [{"i": "CL:0002114", "l": "CD38-positive unswitched memory B cell", "d": ["A CD38-positive unswitched memory B cell is an unswitched memory B cell that has the phenotype CD38-positive, IgD-positive, CD138-negative, and IgG-negative."]}]}
{"type": "biolink:Cell", "ic": "70.365551207689407", "identifiers": [{"i": "UMLS:C0229951", "l": "Thymic epithelial cell", "d": []}, {"i": "NCIT:C33771", "l": "Thymic Epithelial Cell", "d": ["A reticular epithelial cell generated in the thymus that affects T-lymphocyte cell production. Thymic epithelial cells are organized in a three-dimensional network rather than as a sheet of cells on a basement membrane."]}, {"i": "SNOMEDCT:81596002", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5220558", "l": "Bladder cells|Urine/Urine sed", "d": []}]}
{"type": "biolink:Cell", "ic": "78.435418415656045", "identifiers": [{"i": "UMLS:C1518242", "l": "Malignant Small Hyperchromatic Cell", "d": []}, {"i": "NCIT:C36861", "l": "Malignant Small Hyperchromatic Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0003042", "l": "M9-OFF retinal ganglion cell", "d": ["An M9 retinal ganglion cell with synaptic terminals in S4 that is depolarized by decreased illumination of their receptive field center"]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C4727694", "l": "Autologous Anti-Claudin18.2-transduced T Lymphocytes CT041", "d": []}, {"i": "NCIT:C150382", "l": "Autologous Anti-Claudin18.2-transduced T Lymphocytes CT041", "d": ["A preparation of autologous T-lymphocytes ex vivo transduced with a lentiviral vector encoding for a chimeric antigen receptor (CAR) specific for the tumor-associated antigen (TAA) Claudin18.2 (CLDN18.2; A2 isoform of claudin-18), with potential immunostimulating and antineoplastic activities. Upon administration, the autologous anti-CLDN18.2CAR-transduced T lymphocytes specifically recognize and induce selective toxicity in CLDN18.2-expressing tumor cells. CLDN18.2, a tight junction protein, is expressed on a variety of tumor cells, but its expression in healthy tissues is strictly confined to short-lived differentiated epithelial cells of the gastric mucosa."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1267813", "l": "Lymphocyte positive for CD2 antigen", "d": []}, {"i": "SNOMEDCT:117516003", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C3641631", "l": "FAP-specific CD8-positive T Cells", "d": []}, {"i": "NCIT:C103829", "l": "FAP-specific CD8-positive T Cells", "d": ["A preparation of CD8-positive T cells specific for human fibroblast activating protein (FAP) with potential immunopotentiating activity. T cells have been genetically modified to express a chimeric antigen receptor specific for FAP. Upon infusion, the FAP-specific CD8-positive T cells bind to FAP-expressing tumor cells and exhibit a selective toxicity to tumor cells. This may result in both tumor cell lysis and inhibition of tumor cell growth. FAP, a cell surface glycoprotein, is overexpressed on tumor-associated fibroblasts but minimally expressed on normal, healthy cells."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5380993", "l": "Cells.CD8.HLA-B35 CMV specific.CMV antigen stimulated gamma interferon producing", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C3897804", "l": "RNA Electroporated CD19CAR-CD3zeta-4-1BB-expressing Autologous T-lymphocytes", "d": []}, {"i": "NCIT:C118947", "l": "RNA Electroporated CD19CAR-CD3zeta-4-1BB-expressing Autologous T-lymphocytes", "d": ["Autologous, genetically engineered T-lymphocytes that have been electroporated with an mRNA encoding for an anti-CD19 chimeric antigen receptor (CAR) consisting of an anti-CD19 single chain variable fragment (scFv) coupled to the co-stimulatory signaling domain of 4-1BB (CD137) and the zeta chain of the T-cell receptor CD3 complex (CD3-zeta), with potential immunomodulating and antineoplastic activities.  Upon transfusion, the RNA electroporated CD19CAR-CD3zeta-4-1BB-expressing autologous T-lymphocytes attach to cancer cells expressing CD19. This induces selective toxicity against CD19-expressing tumor cells and causes tumor cell lysis. The 4-1BB co-stimulatory molecule signaling domain enhances T-cell activation and signaling after recognition of CD19. CD19 antigen is a B-cell specific cell surface antigen, which is expressed in all B-cell lineage malignancies."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C4764236", "l": "Citrate Blood Cell Fraction", "d": []}, {"i": "NCIT:C158461", "l": "Citrate Blood Cell Fraction", "d": ["The blood cells that are harvested from a cell collection tube containing sodium citrate."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5174619", "l": "Neutrophils | Nose | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1183406", "l": "Epithelial cell of gut", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1257913", "l": "Polyploid Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1514067", "l": "Neoplastic Plump Epithelial Cell", "d": []}, {"i": "NCIT:C36886", "l": "Neoplastic Plump Epithelial Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "75.751739371353352", "identifiers": [{"i": "UMLS:C1512102", "l": "Dysplastic Erythroid Precursor", "d": []}, {"i": "NCIT:C37054", "l": "Dysplastic Erythroid Precursor", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0003032", "l": "M3-OFF retinal ganglion cell", "d": ["A monostratified retinal ganglion cell that has post synaptic terminals in sublaminar layer S2 and is depolarized by decreased illumination of their receptive field center"]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1953343", "l": "Chromosome number", "d": []}]}
{"type": "biolink:Cell", "ic": "54.809513488357567", "identifiers": [{"i": "CL:0000586", "l": "germ cell", "d": ["The reproductive cell in multicellular organisms."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157618", "l": "CD56 cells | Blood | Cell markers", "d": []}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "CL:0002675", "l": "H plus", "d": ["A S. pombe cell type determined by mat1-Pc and mat1-Pi on the mat1 locus."]}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "CL:0009066", "l": "stratified squamous epithelial cell of anal canal", "d": ["A stratified squamous epithelial cell that is part of the anal canal."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1440108", "l": "Autologous erythrocytes", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1507176", "l": "Cells.CD4+CD95+", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2350052", "l": "Granulocyte Progenitor Cells", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2328068", "l": "Type TG enteroendocrine cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4322731", "l": "CD22+ B lymphocyte", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2333912", "l": "Transitional myocyte of middle internodal tract", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5163436", "l": "Eosinophils | Blood cord | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "ic": "86.236661114203869", "identifiers": [{"i": "CL:0004252", "l": "medium field retinal amacrine cell", "d": ["An amicrine that has a medium dendritic field."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4284514", "l": "Cells.chromosome region 17p13.1", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C2936598", "l": "Pancreatic Stellate Cells", "d": []}, {"i": "NCIT:C107531", "l": "Pancreatic Stellate Cell", "d": ["A star-shaped, myofibroblast-like cell in the pancreas associated with tissue maintenance. When pancreatic stellate cells are activated in response to an injury, they proliferate and synthesize large amounts of extracellular matrix. Pancreatic cancer cells can increase the activation of pancreatic stellate cells, which leads to fibrosis."]}, {"i": "MESH:D058954", "l": "Pancreatic Stellate Cells", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0333823", "l": "Smudge cell", "d": []}, {"i": "SNOMEDCT:34717007", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1440258", "l": "Cells.CD16+CD57-", "d": []}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "UMLS:C1513979", "l": "Neoplastic Glomerulosa Cell", "d": []}, {"i": "NCIT:C36927", "l": "Neoplastic Glomerulosa Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1513081", "l": "Mouse Megakaryocyte", "d": []}, {"i": "NCIT:C22567", "l": "Mouse Megakaryocyte", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5216223", "l": "Large unstained cells|NCnc|Pt|Bld", "d": []}]}
{"type": "biolink:Cell", "ic": "84.128890093485552", "identifiers": [{"i": "UMLS:C0022687", "l": "Lymphokine-Activated Killer Cells", "d": []}, {"i": "NCIT:C13008", "l": "Lymphokine-Activated Killer Cells", "d": ["Killer cell lymphocytes activated in the presence of interleukin-2 (IL-2).  Lymphokine-activated killer cells (LAKs) are cytotoxic effector cells with an exceptionally wide target cell spectrum including normal and malignant cells of different origins.  LAK cells exhibit a profound heterogeneity with regard to phenotype surface marker expression; it remains to be determined if they represent a unique cell lineage."]}, {"i": "MESH:D015979", "l": "Killer Cells, Lymphokine-Activated", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0000470", "l": "digestive enzyme secreting cell", "d": []}]}
{"type": "biolink:Cell", "ic": "92.728541327098611", "identifiers": [{"i": "CL:0000998", "l": "CD8_alpha-negative CD11b-negative dendritic cell", "d": ["CD8_alpha-negative CD11b-negative dendritic cell is a conventional dendritic cell that is CD11b-negative, CD4-negative CD8_alpha-negative and is CD205-positive. This cell is able to cross- present antigen to CD8-alpha-positive T cells."]}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "CL:0001027", "l": "CD7-negative lymphoid progenitor cell", "d": ["CD7-negative lymphoid progenitor cell is a lymphoid progenitor cell that is CD34-positive, CD7-negative and CD45RA-negative."]}]}
{"type": "biolink:Cell", "ic": "87.120474278337809", "identifiers": [{"i": "CL:0000730", "l": "leading edge cell", "d": ["A cell at the front of a migrating epithelial sheet."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5382905", "l": "HLA-A2 CMV specific CD8 cells | Blood | Cell markers", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002094", "l": "interstitial cell of ovary", "d": ["A cell that makes up the loose connective tissue of the ovary."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2329330", "l": "H I cell of retina", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2327465", "l": "Transitional myocyte of septal division of left branch of atrioventricular bundle", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C3899816", "l": "CD28CAR/CD137CAR-expressing T-Lymphocytes", "d": []}, {"i": "NCIT:C117232", "l": "CD28CAR/CD137CAR-expressing T-Lymphocytes", "d": ["Third generation, chimeric antigen receptor (CAR) cells composed of T-lymphocytes transduced with a lentiviral vector expressing a CAR consisting of an a single chain variable fragment specific for a particular antigen, coupled to the two co-stimulatory signaling domains Cluster of Differentiation 28 (CD28) and Cluster of Differentiation 137 (CD137; 4-1BB), and the zeta chain of the T-cell receptor (TCR)/CD3 complex (CD3-zeta), with potential immunomodulating and antineoplastic activities. Upon transfusion, CD28CAR/CD137CAR-expressing T-lymphocytes are directed to, and induce selective toxicity in tumor cells expressing the particular antigen. CD28, a T-cell surface-associated co-stimulatory molecule, is required for T-cell activation, proliferation, and survival. The 4-1BB co-stimulatory molecule signaling domain enhances activation and signaling after recognition of the antigen. Furthermore, inclusion of the 4-1BB signaling domain may increase the antitumor activity when compared to the inclusion of the CD28 co-stimulatory domain and CD3-zeta alone."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C0079852", "l": "Monocytes, Activated Killer", "d": []}, {"i": "NCIT:C12548", "l": "Monocyte, Activated Killer", "d": ["A monocyte that has been activated for cytotoxicity by gamma interferon."]}, {"i": "MESH:D016260", "l": "Monocytes, Activated Killer", "d": []}]}
{"type": "biolink:Cell", "ic": "92.728541327098611", "identifiers": [{"i": "CL:0000774", "l": "band form eosinophil", "d": ["A late eosinophilic metamyelocyte in which the nucleus is in the form of a curved or coiled band, not having acquired the typical multilobar shape of the mature eosinophil."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5163726", "l": "Erythrocytes | Stool | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "ic": "84.75972595860604", "identifiers": [{"i": "CL:0002145", "l": "ciliated columnar cell of tracheobronchial tree", "d": ["A ciliated columnar cell found in the trachea and bronchus. Vary from low to tall columnar; possesses up to 300 cilia at its surface, interspersed with long irregular microvilli with the cilia varying in length from about 6um in the trachea to about 4um in the terminal bronchioles; driving force of the ciliary current in the bronchial tree."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C4329309", "l": "Anti-ACTR/4-1BB/CD3zeta-Viral Vector-transduced Autologous T-Lymphocytes ACTR087", "d": []}, {"i": "NCIT:C129715", "l": "Anti-ACTR/4-1BB/CD3zeta-Viral Vector-transduced Autologous T-Lymphocytes ACTR087", "d": ["Autologous T-lymphocytes that are genetically modified and transfected with a viral vector expressing the ACTR gene, a proprietary gene encoding for an antibody-coupled T-cell receptor (ATCR), with potential antineoplastic activity. The ACTR contains the extracellular Fc receptor CD16 domain, normally found on certain immune cells, such as natural killer (NK) cells, coupled to the co-immunostimulatory signaling domain 4-1BB, normally expressed on T-cells, and linked to the intracellular CD3 zeta domain (CD3z), which is needed for TCR signaling. Upon reintroduction into the patient and co-administration of a cancer-specific antibody, the co-administered antibody targets and binds to the tumor-associated antigen (TAA) expressed on the tumor cell. In turn, this induces the activation of the ACTR087 cells and destruction of the tumor cells by a) releasing cytotoxins that directly kill cancer cells; b) releasing cytokines that trigger an immune response and recruit other immune-mediated killer cells to kill the tumor cells; b) targeting and killing adjacent tumor cells that are not bound to the antibody; c) inducing T-cell proliferation and thereby further enhancing the T-cell mediated tumor cell attack. CD3 zeta is one of several membrane-bound polypeptides found in the TCR/CD3 complex; it enhances the survival and persistence of T-lymphocytes. The 4-1BB co-stimulatory molecule signaling domain enhances activation and signaling after recognition of the TAA."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5205502", "l": "Allogeneic CD25/Treg-depleted Donor Lymphocytes", "d": []}, {"i": "NCIT:C160729", "l": "Allogeneic CD25/Treg-depleted Donor Lymphocytes", "d": ["A preparation of allogeneic peripheral blood mononuclear cells (PBMCs) derived from an 8/8 HLA-matched donor that have been selectively depleted of CD4+CD25hiFoxp3+ regulatory T-cells (Tregs; CD25hi Tregs) with potential to enhance graft-versus-tumor (GVT) immune responses in patients with myeloid relapse following a hematopoietic stem cell transplant (HSCT) from a matched donor. Following collection and ex-vivo depletion of CD25hi Tregs from PBMCs derived from the original donor, the CD25/Treg-depleted donor lymphocytes are infused into the patient. Upon administration, the CD25/Treg-depleted donor lymphocyte infusion (DLI) may enhance the proliferation of CD4+ and CD8+ effector T-cells (Teffs) and potentially induce curative GVT immune responses in patients with myeloid relapse following HSCT."]}]}
{"type": "biolink:Cell", "ic": "78.185623981295834", "identifiers": [{"i": "CL:0000801", "l": "gamma-delta intraepithelial T cell", "d": ["A mature gamma-delta T cell that is found in the columnar epithelium of the gastrointestinal tract. These cells participate in mucosal immune responses."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1514167", "l": "Pleomorphic B-Lymphocyte", "d": []}, {"i": "NCIT:C36996", "l": "Pleomorphic B-Lymphocyte", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5761797", "l": "OriCar-017", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2338356", "l": "Basal cell of epithelium of trachea", "d": []}]}
{"type": "biolink:Cell", "ic": "90.82444074280258", "identifiers": [{"i": "UMLS:C1519378", "l": "Small Meningothelial Cell", "d": []}, {"i": "NCIT:C37161", "l": "Small Meningothelial Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:4028002", "l": "alveolar capillary type 1 endothelial cell", "d": ["An alveolar capillary endothelial cell that is located distally to alveolar capillary type 2 endothelial cells."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002498", "l": "secondary trophoblast giant cell", "d": ["A trophoblast giant cell that is derived from ectoplacental cone and, later in gestation, the spongiotrophoblast."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1720858", "l": "Adipocytes, White", "d": []}, {"i": "MESH:D052438", "l": "Adipocytes, White", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0000204", "l": "acceleration receptive cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4696640", "l": "Cells.CD4+CD25-CD127+", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5417833", "l": "Autologous CRISPR-edited Anti-CD19 CAR T Cells XYF19", "d": []}, {"i": "NCIT:C170914", "l": "Autologous CRISPR-edited Anti-CD19 CAR T Cells XYF19", "d": ["A preparation of autologous T-lymphocytes transduced with a lentiviral vector encoding a chimeric antigen receptor (CAR) specific for the tumor-associated antigen (TAA) CD19, and electroporated with clustered regularly interspaced short palindromic repeats (CRISPR) guide RNA to disrupt expression of endogenous hematopoietic progenitor kinase 1 (HPK1), with potential immunostimulating and antineoplastic activities. Upon introduction into the patient, the autologous CRISPR-edited anti-CD19 CAR T-cells XYF19 recognize and bind to CD19-overexpressing tumor cells. This may result in a specific cytotoxic T-lymphocyte (CTL)-mediated killing of CD19-positive tumor cells. Disrupting the expression of HPK1 may enhance immune response and autoimmunity. CD19 antigen is a B-cell specific cell surface antigen expressed in all B-cell lineage malignancies. HPK1 is a Ste20-like serine/threonine kinase that suppresses immune responses and autoimmunity."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2326918", "l": "Microfold cell of epithelium proper of appendix", "d": []}]}
{"type": "biolink:Cell", "ic": "84.128890093485552", "identifiers": [{"i": "CL:1001603", "l": "lung macrophage", "d": ["Circulating macrophages and tissue macrophages (alveolar macrophages) of lung."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1267844", "l": "Lymphoblast positive for CD5 antigen", "d": []}, {"i": "SNOMEDCT:117531007", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5175162", "l": "Nucleated erythrocytes | XXX | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2334654", "l": "Type A cell of stomach", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2599785", "l": "Granulocytes.CD59 deficient", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1180924", "l": "Non-nucleated cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1181297", "l": "Light chief cell of parathyroid gland", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2924224", "l": "Cells.CD25+C69+", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0008013", "l": "cranial visceromotor neuron", "d": ["A visceromotor motor neuron whose soma is located in the hindbrain, and which synapses to parasympathetic neurons that innervate tear glands, sweat glands, and the smooth muscles of the head."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2709116", "l": "Cells.CD5+CD19+CD38+", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0000684", "l": "littoral cell of liver", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0229645", "l": "Basophilic promyelocyte", "d": []}, {"i": "SNOMEDCT:71170001", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:1000276", "l": "smooth muscle fiber of duodenum", "d": ["A smooth muscle cell that is part of the duodenum."]}]}
{"type": "biolink:Cell", "ic": "90.82444074280258", "identifiers": [{"i": "UMLS:C1516899", "l": "Eosinophilic Brown Fat Cell", "d": []}, {"i": "NCIT:C36969", "l": "Eosinophilic Brown Fat Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "69.78964318410506", "identifiers": [{"i": "CL:0000020", "l": "spermatogonium", "d": ["An euploid male germ cell of an early stage of spermatogenesis."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5418106", "l": "Autologous Anti-CD19CAR-4-1BB/CD3zeta-HER2tG-expressing CD4+/CD8+ T-lymphocytes SCRI-huCAR19v2", "d": []}, {"i": "NCIT:C174563", "l": "Autologous Anti-CD19CAR-4-1BB/CD3zeta-HER2tG-expressing CD4+/CD8+ T-lymphocytes SCRI-huCAR19v2", "d": ["A preparation of autologous CD4- and CD8-positive T-lymphocytes that have been transduced with a lentiviral vector (LV) expressing a chimeric antigen receptor (CAR) specific for the human tumor-associated antigen (TAA) CD19 that is fused to the intracellular cytoplasmic domain of 4-1BB (CD137) and the zeta chain of the TCR/CD3 complex (CD3zeta), and linked to a truncated form of the human epidermal growth factor receptor 2 (HER2tG), with potential immunostimulating and antineoplastic activities. Upon administration, the autologous anti-CD19CAR-4-1BB/CD3zeta-HER2tG-expressing CD4+/CD8+ T-lymphocytes SCRI-huCAR19v2 specifically target and bind to CD19-expressing neoplastic B-cells. This results in a cytotoxic T-lymphocyte (CTL) response against CD19-expressing tumor cells and causes tumor cell lysis. CD19 is a B-cell-specific cell surface antigen that is overexpressed in B-cell lineage tumors. Incorporation of the costimulatory signaling domain increases human T-cell function, expansion, and survival. Devoid of both ligand binding domains and tyrosine kinase activity, the co-expressed HER2tG both facilitates in vivo detection of the administered, transduced T-cells and can promote elimination of those cells through a trastuzumab-induced antibody dependent cellular cytotoxicity (ADCC) response."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5163542", "l": "Epithelial cells | Urine | Urinalysis", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5706521", "l": "Allogeneic Natural Killer Cells DVX201", "d": []}, {"i": "NCIT:C188962", "d": []}]}
{"type": "biolink:Cell", "ic": "90.82444074280258", "identifiers": [{"i": "CL:0002523", "l": "mesonephric podocyte", "d": ["A specialized epithelial cell that contains \"feet\" that interdigitate with the \"feet\" of other glomerular epithelial cells in the mesonephros."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002383", "l": "conidium of conidiophore head", "d": ["A uninucleate spore formed on specialized cells or projections, sterigma, of a conidiophore head."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1514182", "l": "Mesothelial cell of pleura", "d": []}, {"i": "NCIT:C33330", "l": "Pleural Mesothelial Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0000732", "l": "amoeboid cell", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1513715", "l": "Mucinous Bronchial Cell", "d": []}, {"i": "NCIT:C33922", "l": "Mucinous Bronchial Cell", "d": ["A columnar epithelial cell found in the bronchi. It secretes mucus."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1257909", "l": "Diploid Cell", "d": []}, {"i": "NCIT:C12949", "l": "Somatic Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1515151", "l": "TE33", "d": []}, {"i": "NCIT:C20298", "l": "TE33", "d": ["Provider: Technion University, Haifa, Israel. No information from provider. This cell line meets the criteria for the use of human embryonic stem cells by federally funded researchers."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2324238", "l": "Transitional myocyte of anterior division of left branch of atrioventricular bundle", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1440350", "l": "Cells.CD3-CD7+", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C4724905", "l": "Autologous PD-L1/CD80/CD86-targeted CAR-T Cells", "d": []}, {"i": "NCIT:C148216", "l": "Autologous PD-L1/CD80/CD86-targeted CAR-T Cells", "d": ["A preparation of autologous human T-lymphocytes engineered to express a chimeric antigen receptor (CAR) composed of a modified from of the human inhibitory receptor programmed cell death protein 1 (PD-1; PDCD1), in which the intracellular signal domain of PD-1 is transformed to allow for stimulatory signaling but with an intact extracellular ligand binding domain that specifically binds the tumor-associated antigen (TAA) programmed cell death-1 ligand 1 (PD-L1), and a modified form of the T-cell inhibitory receptor cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4), with a transformed intracellular signal domain to allow for stimulatory signaling, which specifically binds the B7 proteins CD80 (B7-1) and CD86 (B7-2), with potential immunostimulating and antineoplastic activities. Usually, ligand binding to PD-1 and CTLA-4 inhibits T-cell activity; however, these modified forms of PD-1 and CTLA-4 promote T-cell stimulatory signaling. Upon administration, the autologous PD-L1/CD80/CD86-targeted CAR-T cells target and bind to PD-L1 expressed on certain tumor cells and to CD80/CD86 expressed on antigen-presenting cells (APCs). This stimulates T-cell activation, T-cell proliferation and enhanced cytokine production, which induces selective toxicity in tumor cells expressing PD-L1. PD-1, found on activated T-cells, negatively regulates T-cell activity; it plays a key role in immune evasion and prevents tumor cell lysis. PD-L1 is often overexpressed on tumor cell types and plays a key role in immune evasion. The co-stimulatory molecules CD80 and CD86 play a key role in T-lymphocyte activation upon binding to CD28 upon antigen recognition; however, binding of CD80 and CD86 to wild-type CTLA-4 inhibits T-cell activity and results in T-cell exhaustion."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5690102", "l": "Cells.CD4.Interferon gamma-expressing", "d": []}]}
{"type": "biolink:Cell", "ic": "60.718318631034926", "identifiers": [{"i": "CL:0001200", "l": "lymphocyte of B lineage, CD19-positive", "d": ["A lymphocyte of B lineage that is CD19-positive."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C4723769", "l": "Therapeutic Invariant Natural Killer T-cells", "d": []}, {"i": "NCIT:C148557", "l": "Therapeutic Invariant Natural Killer T-cells", "d": ["A preparation of natural killer T-cells (NKTs) expressing an invariant (alpha, beta) T-cell receptor (iNKTs), with potential immunomodulating and antineoplastic activities. Upon infusion of the therapeutic iNKTs, these cells recognize CD1d-restricted lipid ligands, which are expressed on certain tumor cells, and secrete large amounts of various cytokines. This may activate the immune system against tumor cells. Additionally, iNKTs directly target and lyse tumor cells."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:4023113", "l": "bouton vestibular afferent neuron", "d": ["A vestibular afferent neuron that makes bouton synapses to type II hair cells."]}]}
{"type": "biolink:Cell", "ic": "54.896128904390018", "identifiers": [{"i": "UMLS:C1440938", "l": "Immature Lymphocyte", "d": []}, {"i": "NCIT:C13118", "l": "Immature Lymphocyte", "d": ["A cell that develops from hematopoietic stem cells. An immature lymphocyte represents of one of five stages of lymphocyte maturation. It is estimated 90% of immature lymphocytes die in the thymus and bone marrow."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1267950", "l": "Lymphocyte positive for CD58 antigen", "d": []}, {"i": "SNOMEDCT:117391008", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0882894", "l": "Cells.CD5+CD20+", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1267581", "l": "Gastric mucous gland neck cell", "d": []}, {"i": "SNOMEDCT:110605001", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:1001597", "l": "seminal vesicle glandular cell", "d": ["Glandular cell of seminal vesicle epithelium."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157542", "l": "CD4+CD29+ cells | Blood | Cell markers", "d": []}]}
{"type": "biolink:Cell", "ic": "62.116924269856", "identifiers": [{"i": "CL:1000497", "l": "kidney cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4240447", "l": "Vascular smooth muscle cell of abdominal aorta", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1510929", "l": "Autologous Anti-MART-1 F5 T-Cell Receptor Gene-Engineered Peripheral Blood Lymphocytes", "d": []}, {"i": "NCIT:C38587", "l": "Autologous Anti-MART-1 F5 T-Cell Receptor Gene-Engineered Peripheral Blood Lymphocytes", "d": ["Human autologous peripheral blood lymphocytes (PBLs) transduced with a melanoma antigen MART-1 epitope-determined T cell receptor (TCR) gene, with potential antineoplastic activity. PBLs are isolated from a melanoma patient and pulsed with a viral vector that encodes the TCR specific for an epitope of MART-1 (F5 TCR). After expansion ex vivo, the transduced autologous PBLs, expressing this specific TCR, are reintroduced into the patient, and bind to melanoma cells expressing the MART-1 antigen, which may result in specific cytotoxic T-lymphocyte (CTL) killing of MART-1-expressing melanoma cells. MART-1 (melanoma antigen recognized by T cells 1), also known as Melan-A, is a melanocyte lineage-specific transmembrane protein."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0546491", "l": "P.B. myeloblast", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157647", "l": "CD69 cells | Blood | Cell markers", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1292101", "l": "IgM B lymphocyte", "d": []}, {"i": "SNOMEDCT:115607006", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C3640209", "l": "Mesothelin-specific Chimeric Antigen Receptor-engineered Peripheral Blood Lymphocytes", "d": []}, {"i": "NCIT:C101773", "l": "Mesothelin-specific Chimeric Antigen Receptor-engineered Peripheral Blood Lymphocytes", "d": ["A preparation of peripheral blood lymphocytes (PBLs) transduced with a retroviral vector encoding a T cell chimeric antigen receptor (CAR) specific for mesothelin with potential immunostimulatory and antineoplastic activities. After transduction, expansion in culture, and reintroduction into the patient, the mesothelin-specific chimeric antigen receptor-engineered PBLs bind to tumor cells expressing mesothelin. This may stimulate the secretion of cytokines and result in cell lysis of mesothelin-expressing cancer cells. Mesothelin, a cell surface glycoprotein involved in cell adhesion, is overexpressed in many epithelial-derived cancers."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2953150", "l": "Type D enteroendocrine cell of epithelium of principal gastric gland", "d": []}]}
{"type": "biolink:Cell", "ic": "61.133821031307569", "identifiers": [{"i": "CL:0000019", "l": "sperm", "d": ["A mature male germ cell that develops from a spermatid."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002236", "l": "basal epithelial cell of prostatic duct", "d": ["A cell that constitutes the basal layer of epithelium in the prostatic duct."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C4055460", "l": "Anti-CEA-CAR Autologous T Lymphocytes", "d": []}, {"i": "NCIT:C121784", "l": "Anti-CEA-CAR Autologous T Lymphocytes", "d": ["Autologous lymphocytes transduced with a retroviral vector encoding a chimeric antigen receptor (CAR) specific for the tumor-associated antigen human carcinoembryonic antigen (CEA), with potential immunostimulating and antineoplastic activities. Upon administration, the anti-CEA-CAR autologous T-lymphocytes target and bind to tumor cells expressing CEA, which results in the cytotoxic T-lymphocyte (CTL)-mediated cell killing of CEA-expressing tumor cells. CEA is overexpressed in various tumor cell types."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5170903", "l": "Leukocyte clumps | Urine | Urinalysis", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5175160", "l": "Nucleated erythrocytes | Fetus | Blood | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5163723", "l": "Erythrocytes | Prostatic fluid | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "ic": "87.120474278337809", "identifiers": [{"i": "UMLS:C1709182", "l": "Neoplastic Large Striated Muscle Cell with Clear Cytoplasm", "d": []}, {"i": "NCIT:C49169", "l": "Neoplastic Large Striated Muscle Cell with Clear Cytoplasm", "d": []}]}
{"type": "biolink:Cell", "ic": "75.751739371353352", "identifiers": [{"i": "UMLS:C1522104", "l": "Spindle Melanoma Cell", "d": []}, {"i": "NCIT:C36874", "l": "Spindle Melanoma Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:4023095", "l": "untufted pyramidal neuron", "d": ["A pyramidal neuron which lacks a clear tuft formation but extends to large radial distances."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2322731", "l": "Type 2 vestibular sensory cell of epithelium of macula of saccule of membranous labyrinth", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5670964", "l": "Autologous PBMC-derived Engineered Leukocyte Immunostimulatory Cells-activated Effector Cells", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1267982", "l": "Lymphocyte positive for CD95 antigen", "d": []}, {"i": "SNOMEDCT:117422005", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:4023003", "l": "nuclear chain fiber", "d": ["A type of intrafusal muscle fiber that has nuclei arranged in a linear row. Unlike nuclear bag fibers, the equatorial region of these fibers (in the centre of the spindle) is not expanded. These fibers are responsible for the detection of changes in muscle length. They are innervated by static gamma motor neurons and are principally associated with type II sensory fibers."]}]}
{"type": "biolink:Cell", "ic": "76.281523396999802", "identifiers": [{"i": "UMLS:C1514086", "l": "Neoplastic Small Cleaved Follicle Center Cell", "d": []}, {"i": "NCIT:C37002", "l": "Neoplastic Small Cleaved Follicle Center Cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1317200", "l": "Cells.CD59", "d": []}]}
{"type": "biolink:Cell", "ic": "63.780315893996587", "identifiers": [{"i": "CL:0002159", "l": "general ecto-epithelial cell", "d": ["Epithelial cells derived from general body ectoderm and ectoderm placodes."]}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "CL:0000919", "l": "CD8-positive, CD25-positive, alpha-beta regulatory T cell", "d": ["A CD8-positive alpha beta-positive T cell with the phenotype FoxP3-positive and having suppressor function."]}]}
{"type": "biolink:Cell", "ic": "92.728541327098611", "identifiers": [{"i": "CL:0000602", "l": "pressoreceptor cell", "d": ["A receptor in the vascular system, particularly the aorta and carotid sinus, which is sensitive to stretch of the vessel walls."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002270", "l": "type EC2 enteroendocrine cell", "d": ["A type EC enteroendocrine cell in the duodenum and jejunum that stores and secretes motilin and 5-hydroxytryptamine."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5186857", "l": "Nucleated erythrocytes | Fetus | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2328498", "l": "Pacemaker cell of sinuatrial node", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C3899738", "l": "CXCR2-transduced Autologous Tumor Infiltrating Lymphocytes", "d": []}, {"i": "NCIT:C120001", "l": "CXCR2-transduced Autologous Tumor Infiltrating Lymphocytes", "d": ["A preparation of autologous tumor infiltrating lymphocytes (TILs) that are transduced, ex vivo, with a retroviral vector encoding a gene for CXC chemokine receptor 2 (CXCR2), with potential antineoplastic activity. Upon administration of the CXCR2-transduced autologous TILs, the CXCR2-expressing T-cells selectively migrate toward tumor cells expressing CXCR2 ligands, which leads to tumor cell killing. CXCR2 expression allows for optimal TIL migration towards tumor cells and enhances the TILs anti-tumor activity. This leads to a reduction in both tumor cell proliferation and survival. CXCR2, a transmembrane protein also known as IL-8 receptor B (IL-8RB), plays a key role in inflammation and cancer progression. Certain CXCR2 ligands, such as CXCL1 and CXCL8 (IL-8), are expressed by tumor cells."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0427536", "l": "white blood cell type", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157926", "l": "Cells | Synovial fluid | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5427575", "l": "Ganglion cells.right", "d": []}]}
{"type": "biolink:Cell", "ic": "92.728541327098611", "identifiers": [{"i": "UMLS:C4277548", "l": "Cancer-Associated Fibroblasts", "d": []}, {"i": "NCIT:C168534", "l": "Cancer-Associated Fibroblast", "d": ["A fibroblast found proximal to or within cancerous tissue."]}, {"i": "MESH:D000072645", "l": "Cancer-Associated Fibroblasts", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2324639", "l": "Retinal glial cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157430", "l": "CD3+CD25+ cells | Blood | Cell markers", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5668164", "l": "CD19x22 Bicistronic CAR T-cells", "d": []}, {"i": "NCIT:C183133", "l": "CD19x22 Bicistronic CAR T-cells", "d": ["A preparation of T-lymphocytes that have that have been transduced with a bicistronic vector encoding two distinct chimeric antigen receptors (CARs), one against the tumor-associated antigen (TAA) CD19 and the other one against the TAA CD22, with potential immunomodulating and antineoplastic activities. Upon administration, the CD19x22 bicistronic CAR T-cells target, bind to and induce selective toxicity in tumor cells expressing CD19 and CD22. CD19 and CD22, both transmembrane phosphoglycoproteins expressed on the surface of cells in the B lineage, are often overexpressed on malignant B-cells. By simultaneously targeting two B-cell antigens using two different CARs, this preparation may minimize relapse due to single antigen loss in patients with B-cell malignancies."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157626", "l": "CD59 Granulocytes | Blood | Cell markers", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C4053747", "l": "Allogeneic Mesothelioma Tumor Lysate-pulsed Autologous Dendritic Cell Vaccine", "d": []}, {"i": "NCIT:C121640", "l": "Allogeneic Mesothelioma Tumor Lysate-pulsed Autologous Dendritic Cell Vaccine", "d": ["A cell-based cancer vaccine composed of autologous dendritic cells (DCs) pulsed with a mixture of lysates from five allogeneic mesothelioma tumor cell lines, with potential immunostimulatory and antineoplastic activities. Upon leukapheresis, DCs are loaded with allogeneic mesothelioma tumor cell lysates. Upon re-administration of the allogeneic mesothelioma tumor lysate-pulsed autologous DC vaccine, the immune system is exposed to an undefined amount of mesothelioma-associated antigens, which stimulates the induction of a specific cytotoxic T-lymphocyte (CTL) response against mesothelioma tumor cells and leads to tumor cell lysis."]}]}
{"type": "biolink:Cell", "ic": "68.149273381153577", "identifiers": [{"i": "UMLS:C1512971", "l": "Malignant Thyroid Gland Follicular Cell", "d": []}, {"i": "NCIT:C36836", "l": "Malignant Thyroid Gland Follicular Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "78.185623981295834", "identifiers": [{"i": "UMLS:C1514069", "l": "Neoplastic Polygonal Cell with Abundant Granular Cytoplasm", "d": []}, {"i": "NCIT:C36852", "l": "Neoplastic Polygonal Cell with Abundant Granular Cytoplasm", "d": []}]}
{"type": "biolink:Cell", "ic": "70.14367232259255", "identifiers": [{"i": "UMLS:C1708905", "l": "Malignant Skeletal Muscle Cell", "d": []}, {"i": "NCIT:C49197", "l": "Malignant Skeletal Muscle Cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5443441", "l": "lisocabtagene maraleucel, CD4 component, 2 of 2", "d": []}]}
{"type": "biolink:Cell", "ic": "92.728541327098611", "identifiers": [{"i": "CL:0000707", "l": "R7 photoreceptor cell", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5555020", "l": "Universal Anti-CD7 CAR T Cells RD13-01", "d": []}, {"i": "NCIT:C178419", "l": "Universal Anti-CD7 CAR T Cells RD13-01", "d": ["A preparation of universal T-lymphocytes that have been genetically engineered to express a chimeric antigen receptor (CAR) directed against the tumor-associated antigen (TAA) CD7, with potential immunostimulating and antineoplastic activities. Upon administration, universal anti-CD7 CAR T cells RD13-01 specifically recognize and bind to CD7-expressing tumor cells, resulting in specific T-cell-mediated tumor cell lysis. CD7 is a transmembrane glycoprotein expressed by T-cells and natural killer (NK) cells and their precursors. It is expressed in the majority of lymphoblastic T-cell leukemias and lymphomas and in a subset of peripheral T-cell lymphomas."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C0391864", "l": "Cytomegaly", "d": []}, {"i": "NCIT:C36735", "l": "Cytomegalic Cell", "d": ["An abnormal cell that contains intranuclear and intracytoplasmic cytomegalovirus inclusion bodies."]}, {"i": "SNOMEDCT:125392001", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5181478", "l": "Spherocytes | Blood | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "ic": "68.423950427221243", "identifiers": [{"i": "CL:0000136", "l": "fat cell", "d": ["A fat-storing cell found mostly in the abdominal cavity and subcutaneous tissue of mammals. Fat is usually stored in the form of triglycerides."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1979696", "l": "Ependymal+Choroid plexus cells", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1267967", "l": "Lymphocyte positive for CD73 antigen", "d": []}, {"i": "SNOMEDCT:117407000", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2348423", "l": "Allogeneic CD4+ Memory Th1-like T Cells/Microparticle-bound Anti-CD3/anti-CD28", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5557410", "l": "Autologous Tumor Killer Cells", "d": []}, {"i": "NCIT:C182001", "l": "Autologous Tumor Killer Cells", "d": ["A preparation of autologous tumor killer cells (TKCs) which consists of the innate immune cells natural killer (NK) cells and gamma delta T (gdT) cells, which are T-lymphocytes that express only gamma chain and delta chain T-cell receptors (TCRs), with potential cytolytic and antineoplastic activities. NK cells and gdT cells are isolated from the patients' peripheral blood mononuclear cells (PBMCs) and co-cultured ex vivo in a certain proportion with TKC technology. Upon administration, autologous TKCs may lyse cancer cells, and further stimulate an anti-tumor immune response."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0004236", "l": "AB broad diffuse-2 amacrine cell", "d": ["An amacrine cell with a medium dendritic field and post-synaptic terminals in S2, S3, and S4. This cell type releases the neurotransmitter gamma-aminobutyric acid (GABA)."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1267850", "l": "Lymphocyte positive for CD6 antigen", "d": []}, {"i": "SNOMEDCT:117536002", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0682540", "l": "spindle cell", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5555854", "l": "Ex Vivo-expanded Allogeneic Gamma 9 Delta 2 T-cells", "d": []}, {"i": "NCIT:C179664", "l": "Ex Vivo-expanded Allogeneic Gamma 9 Delta 2 T-cells", "d": ["A preparation of a subset of ex vivo-expanded, allogeneic T-lymphocytes that express gamma 9 delta 2 T-cell receptors (TCRs), with potential immunomodulating and antineoplastic activities. Upon administration of the ex vivo-expanded allogeneic gamma 9 delta 2 T-cells, these cells secrete interferon-gamma (IFN-g) and exert direct killing of tumor cells. In addition, these cells activate the immune system to exert a cytotoxic T-lymphocyte (CTL) response against tumor cells. Gamma delta T-lymphocytes play a key role in the activation of the immune system and do not require major histocompatibility complex (MHC)-mediated antigen presentation to exert their cytotoxic effect. Gamma 9 delta 2 T-cells, a subset of gamma delta T-cells, may have a stronger association with antitumor immune responses compared with other gamma delta T-cell subtypes."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1317561", "l": "Neutrophils.vacuolated+Segmented", "d": []}]}
{"type": "biolink:Cell", "ic": "66.661584743224637", "identifiers": [{"i": "CL:0000079", "l": "stratified epithelial cell", "d": []}]}
{"type": "biolink:Cell", "ic": "86.236661114203869", "identifiers": [{"i": "CL:0000061", "l": "cementoblast", "d": ["Skeletogenic cell that produces cementum (a bony substance that covers the root of a tooth), is part of the odontogenic papilla, and develops from a precementoblast cell."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0229521", "l": "Perilymphatic cell", "d": []}, {"i": "SNOMEDCT:76535006", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4696708", "l": "Cells.CD19+CD38+IgM+", "d": []}]}
{"type": "biolink:Cell", "ic": "84.75972595860604", "identifiers": [{"i": "CL:0000958", "l": "T1 B cell", "d": ["A transitional stage B cell that migrates from the bone marrow into the peripheral circulation, and finally to the spleen. This cell type has the phenotype surface IgM-positive, surface IgD-negative, CD21-negative, CD23-negative, and CD62L-negative, and CD93-positive. This cell type has also been described as IgM-high, CD19-positive, B220-positive, AA4-positive, and CD23-negative."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1440369", "l": "Cells.CD93", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1254547", "l": "Hypochromic erythrocyte", "d": []}, {"i": "NCIT:C37033", "l": "Hypochromic Red Blood Cell", "d": []}, {"i": "SNOMEDCT:397021001", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5666935", "l": "Dimerizing Agent Regulated Immunoreceptor Complex-expressing CD33-specific Autologous CAR T Cells SC-DARIC33", "d": []}, {"i": "NCIT:C184954", "l": "Dimerizing Agent Regulated Immunoreceptor Complex-expressing CD33-specific Autologous CAR T Cells SC-DARIC33", "d": ["A preparation of equal amounts of autologous CD4-positive and CD8-positive T-lymphocytes transduced with a lentiviral vector expressing a chimeric antigen receptor (CAR) specific for the tumor-associated antigen (TAA) CD33 and genetically modified to express a Dimerizing Agent Regulated Immunoreceptor Complex (DARIC), with potential immunomodulating and antineoplastic activities. Upon transfusion of the DARIC-expressing CD33-specific autologous CAR T-cells SC-DARIC33 and followed by intermittent low dose rapamycin administration, rapamycin binds to DARIC and activates the T-cells when binding to CD33-expressing tumor cells, thereby inducing selective toxicity in CD33-expressing tumor cells. CD33 is expressed on normal non-pluripotent hematopoietic stem cells and on myeloid leukemia cells. The ability of rapamycin to control the activity of the DARIC cells may help control the toxicity of the CAR T-cells, prevent T-cell exhaustion and may help them last longer in vivo. Using the DARIC platform, the antigen recognition and signaling functions of a CAR are separated into two distinct polypeptides and engineered to contain the two interacting and dimerization domains, FK506-binding protein (FKPB12) and FKBP12-rapamycin-binding (FRB) protein. In the absence of the dimerizing drug rapamycin, the CAR T-cells lack signaling activity upon antigen recognition and binding. The administration of the dimerizing agent enables the two DARIC subunits to interact and thereby allows for the CAR T-cells to fully function and activate their signaling abilities upon antigen recognition."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2329862", "l": "Set of adrenergic cells in area postrema [C1]", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2936409", "l": "Palisade Parenchyma Cells", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4323413", "l": "Set of rod cells of inner nuclear layer", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1440251", "l": "Cells.CD120b", "d": []}]}
{"type": "biolink:Cell", "ic": "76.659841615658792", "identifiers": [{"i": "UMLS:C1514040", "l": "Neoplastic Myoepithelial Cell", "d": []}, {"i": "NCIT:C36770", "l": "Neoplastic Myoepithelial Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:1001124", "l": "kidney cortex peritubular capillary cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5181479", "l": "Spherocytes | Blood cord | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2737142", "l": "Monocytes.CD59", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1518125", "l": "MI01", "d": []}, {"i": "NCIT:C20279", "l": "MI01", "d": ["Provider: MizMedi Hospital - Seoul National University, Seoul, Korea. No information from provider. This cell line meets the criteria for the use of human embryonic stem cells by federally funded researchers."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5236007", "l": "FT516", "d": []}, {"i": "NCIT:C164140", "l": "iPSC-derived CD16-expressing Natural Killer Cells FT516", "d": ["An allogeneic, off-the-shelf, natural killer (NK) cell product derived from a clonal master induced pluripotent stem cell (iPSC) line, and engineered to express a high-affinity, non-cleavable CD16 (hnCD16) Fc receptor, with potential antineoplastic and immunostimulatory activities. Upon administration, iPSC-derived CD16-expressing NK cells FT516 bind to the Fc portion of tumor cell-bound monoclonal antibodies and activate NK cell activation, cytokine secretion and antibody-dependent cellular cytotoxicity (ADCC). CD16, also known as Fc-gamma receptor III, is normally expressed on the surface of NK cells, neutrophils, monocytes and macrophages, and plays a key role in initiating ADCC. It is often downregulated in certain cancers, thereby inhibiting the anti-tumor immune response. FT516 NK cells' hnCD16 Fc receptor prevents downregulation and optimizes binding to tumor-targeting antibodies for enhanced ADCC."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5220599", "l": "Leukocytes|Urine/Urine sed", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1514890", "l": "Reserve Cell", "d": []}, {"i": "NCIT:C33916", "l": "Reserve Cell", "d": ["A term that refers to immature cells located between the surface columnar epithelium and the basal layer."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5555516", "l": "Autologous Cytokine-induced Killer Cells/Vaccinia Virus DD-CDSR CRX100", "d": []}, {"i": "NCIT:C179187", "l": "Autologous Cytokine-induced Killer Cells/Vaccinia Virus DD-CDSR CRX100", "d": ["A preparation of autologous cytokine-induced killer (CIK) cells that have been generated ex vivo from killer cells treated with cytokines and infected with the oncolytic vaccinia virus DD-CDSR (vvDD-CDSR; double-deleted vaccinia virus plus CD/SMR), with potential immunomodulatory and antineoplastic activities. CIK cells are CD3- and CD56-positive, non-major histocompatibility complex (MHC)-restricted, natural killer (NK)-like T-lymphocytes. Upon infusion of autologous CIK cells/vvDD-CDSR CRX100, the CIK cells protect the oncolytic virus vvDD-CDSR from immune attack and enhance the delivery of the oncolytic virus to tumor cells. The oncolytic virus vvDD-CDSR preferentially targets and infects tumor cells causing oncolysis. In turn, the lysed tumor cells release various tumor-associated antigens (TAAs), which induce an immune response against the tumor cells."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157497", "l": "CD34+CD117+ blasts | Blood | Cell markers", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1709541", "l": "Piloid Astrocyte", "d": []}, {"i": "NCIT:C45857", "l": "Piloid Astrocyte", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2325127", "l": "Type II enteric ganglion neuron", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C3829574", "l": "iC9-GD2-CD28-OX40-expressing T Lymphocytes", "d": []}, {"i": "NCIT:C106123", "l": "iC9-GD2-CD28-OX40-expressing T Lymphocytes", "d": ["Modified T-lymphocytes expressing a 3rd generation chimeric antigen receptor (CAR) specific for the disialoganglioside GD2, which contains the CD3zeta chain, the signaling domains of the co-stimulatory molecules CD28 and CD134 (OX-40) and the suicide gene inducible caspase 9 (iCasp9), with potential immunomodulating and antineoplastic activities. Upon administration, iC9-GD2-CD28-OX40-expressing T lymphocytes target the GD2 antigen on tumor cells, thereby providing selective toxicity towards GD2-expressing tumor cells. iCasp9 consists of a human FK506 drug-binding domain with an F36V mutation (FKBP12-F36V) linked to human caspase 9. If the administered T cells lead to unacceptable side effects, the chemical homodimerizer AP1903 can be administered, which binds to the drug binding FKBP12-F36V domain and activates caspase 9, resulting in the apoptosis of the administered T-cells. The tumor associated antigen GD2 is overexpressed on the surface of almost all tumors of neuroectodermal origin. OX40 and CD28, both T-cell surface-associated co-stimulatory molecules, are required for full T-cell activation."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2953590", "l": "Type D enteroendocrine cell of epithelium proper of duodenum", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0440752", "l": "Inflammatory cell", "d": []}, {"i": "SNOMEDCT:256923004", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5216232", "l": "Leukocytes|NCnc|Pt|Body fld", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1440353", "l": "Cells.CD74", "d": []}]}
{"type": "biolink:Cell", "ic": "88.140761698499901", "identifiers": [{"i": "CL:0000957", "l": "large pre-B-II cell", "d": ["A large pre-B-II cell is a pre-B-II cell that is proliferating and is Rag1-negative and Rag2-negative."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0009031", "l": "T cell of appendix", "d": ["A T cell that is located in a vermiform appendix."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2950760", "l": "Interdigitating dendritic cell of mucosa-associated lymphoid tissue", "d": []}]}
{"type": "biolink:Cell", "ic": "73.847638787057321", "identifiers": [{"i": "CL:0000062", "l": "osteoblast", "d": ["Skeletogenic cell that secretes osteoid, is capable of producing mineralized (hydroxyapatite) matrix, is located adjacent to or within osteoid tissue, and arises from the transformation of a preosteoblast cell."]}]}
{"type": "biolink:Cell", "ic": "90.82444074280258", "identifiers": [{"i": "CL:1000768", "l": "kidney connecting tubule epithelial cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1440365", "l": "Cells.CD88", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5420485", "l": "CD20-CD19 Compound CAR T Cells", "d": []}, {"i": "NCIT:C173960", "l": "CD20-CD19 Compound CAR T Cells", "d": ["A preparation of T-lymphocytes transduced with a lentiviral vector expressing a compound chimeric antigen receptor (cCAR) containing two distinct units of CARs, one specific for the tumor-associated antigen (TAA) cluster of differentiation 20 (CD20) and one specific for the TAA CD19, with potential immunomodulating and antineoplastic activities. Upon administration, the CD20-CD19 cCAR T cells specifically and simultaneously target and bind to tumor cells expressing CD20 and/or CD19. This induces selective toxicity in tumor cells that express CD20 and/or CD19. Both CD19 and CD20 are B-cell-specific cell surface antigens overexpressed in B-cell lineage malignancies. Targeting two different antigens may improve coverage and protect against antigen escape and relapse as it is less likely for tumor cells to lose both antigens."]}]}
{"type": "biolink:Cell", "ic": "79.849015605436421", "identifiers": [{"i": "CL:0002433", "l": "CD69-positive, CD4-positive single-positive thymocyte", "d": ["A CD4-positive, CD8-negative thymocyte that expresses high levels of the alpha-beta T cell receptor and is CD69-positive."]}]}
{"type": "biolink:Cell", "ic": "58.188159350298456", "identifiers": [{"i": "CL:0000710", "l": "neurecto-epithelial cell", "d": ["Epithelial cells derived from neural plate and neural crest."]}]}
{"type": "biolink:Cell", "ic": "80.869303025598512", "identifiers": [{"i": "CL:1000618", "l": "juxtaglomerular complex cell", "d": []}]}
{"type": "biolink:Cell", "ic": "71.602448984170266", "identifiers": [{"i": "UMLS:C0024432", "l": "macrophage", "d": []}, {"i": "NCIT:C12558", "l": "Macrophage", "d": []}, {"i": "MESH:D008264", "l": "Macrophages", "d": []}, {"i": "SNOMEDCT:58986001", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4528643", "l": "Kymriah", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0000445", "l": "apoptosis fated cell", "d": []}]}
{"type": "biolink:Cell", "ic": "76.281523396999802", "identifiers": [{"i": "CL:0000637", "l": "chromophil cell of anterior pituitary gland", "d": ["A cell that stains readily in the anterior pituitary gland."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1267989", "l": "Lymphocyte positive for CD103 antigen", "d": []}, {"i": "SNOMEDCT:117429001", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1276865", "l": "Entire hilar cell of ovary", "d": []}, {"i": "SNOMEDCT:259185009", "d": []}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "UMLS:C1512333", "l": "Hamster Cell Line", "d": []}, {"i": "NCIT:C20221", "l": "Hamster Cell Line", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2337923", "l": "Purkinje myocyte of atrioventricular node", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4696004", "l": "Cells.CD3+CD8+CD27+CD62L+", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0004139", "l": "retinal ganglion cell A2 outer", "d": ["A retinal ganglion A2 cell with dendrites terminating in S2."]}]}
{"type": "biolink:Cell", "ic": "92.728541327098611", "identifiers": [{"i": "CL:0002577", "l": "placental epithelial cell", "d": ["An epithelial cell of the placenta."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "MESH:D011387", "l": "Prokaryotic Cells", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5163714", "l": "Erythrocytes | Dialysis fluid | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1513965", "l": "Neoplastic Fetal Epithelial Cell", "d": []}, {"i": "NCIT:C37113", "l": "Neoplastic Fetal Epithelial Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "46.441378531856664", "identifiers": [{"i": "CL:0000047", "l": "neural stem cell", "d": ["An undifferentiated neural cell that originates from the neuroectoderm and has the capacity both to perpetually self-renew without differentiating and to generate multiple central nervous system neuronal and glial cell types."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4511161", "l": "Blast cell positive for cytoplasmic CD13 antigen", "d": []}, {"i": "SNOMEDCT:725480006", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157381", "l": "CD20+CD25- cells | Blood | Cell markers", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157486", "l": "CD33 cells | Blood | Cell markers", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C2987368", "l": "Autologous CD8 Positive PBL Sensitized to Drosophila Cell-Presented Melanoma Peptides", "d": []}, {"i": "NCIT:C95715", "l": "Autologous CD8 Positive PBL Sensitized to Drosophila Cell-Presented Melanoma Peptides", "d": ["A preparation of autologous CD8+ (cytotoxic) human peripheral blood lymphocytes (PBLs) sensitized to Drosophila cell-presented melanoma peptides, with potential immunostimulating and antineoplastic activities. Autologous CD8+ T-lymphocytes, isolated from a melanoma patient, are exposed in vitro to melanoma peptide-pulsed HLA-A2-expressing Drosophila cells, expanded, and reintroduced into the patient; these tumor-reactive T-cells may stimulate a host immune response against tumor cells expressing the melanoma antigens, resulting in tumor cell lysis. Drosophila cells, which do not express any native MHC molecules, have been shown to potently stimulate tumor-reactivity in vitro from human peripheral blood lymphocytes (PBL) when stably transfected with human MHC molecules and appropriate adhesion and costimulatory molecules."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5556709", "l": "Autologous Multiple Antigen-specific T-cells MASE-T", "d": []}, {"i": "NCIT:C180908", "l": "Autologous Multiple Antigen-specific T-cells MASE-T", "d": ["A preparation of autologous T-cells targeting multiple antigens expressed by melanoma cells, with potential immunomodulating and antineoplastic activities. Peripheral blood T-cells from the patient are collected, processed with artificial antigen-presenting scaffolds, and enriched and expanded ex-vivo to generate multiple antigen-specific endogenously-derived T-cells (MASE-T) targeting multiple antigens expressed by melanoma cells. Upon administration, the autologous multiple antigen-specific T-cells MASE-T are re-introduced into the patient, where they target and kill melanoma cells expressing these specific antigens."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157272", "l": "CD11c cells | Blood | Cell markers", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0003004", "l": "G3 retinal ganglion cell", "d": ["A bistratified retinal ganglion cell that has a small dendritic field with sparse density that terminates at the intersection of the S4-S5 sublaminar level, and a second dendrite field that is medium in size and degree of arborization that terminates in sublaminar layer S2."]}]}
{"type": "biolink:Cell", "ic": "78.96520244130248", "identifiers": [{"i": "UMLS:C0872076", "l": "Pluripotent Stem Cells", "d": []}, {"i": "NCIT:C12977", "l": "Pluripotent Stem Cell", "d": ["A cell that can differentiate to cells derived from any of the three germ layers. --2005"]}, {"i": "MESH:D039904", "l": "Pluripotent Stem Cells", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1515077", "l": "Olfactory Supporting Cell", "d": []}, {"i": "NCIT:C13152", "l": "Olfactory Supporting Cell", "d": ["A cell that serves to provide support and protection to the olfactory epithelium."]}]}
{"type": "biolink:Cell", "ic": "72.577556932535018", "identifiers": [{"i": "UMLS:C4528422", "l": "NCI-60 Cell Line", "d": []}, {"i": "NCIT:C139309", "l": "NCI-60 Cell Line", "d": ["A panel of 60 different human cancer cell lines grown in culture that were selected to be used in a drug-screening program to identify and characterize novel compounds for growth inhibition or killing of tumor cell lines."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2350331", "l": "Retinal Neurons", "d": []}, {"i": "MESH:D055351", "l": "Retinal Neurons", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5154480", "l": "Basophils | Pericardial fluid | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "ic": "82.076046914303362", "identifiers": [{"i": "CL:0005019", "l": "pancreatic epsilon cell", "d": ["Ghrelin secreting cells found in the endocrine pancreas."]}]}
{"type": "biolink:Cell", "ic": "83.023198044254755", "identifiers": [{"i": "UMLS:C0524984", "l": "Somatostatin-Secreting Cells", "d": []}, {"i": "NCIT:C12574", "l": "Delta Cell", "d": ["A somatostatin-producing cell found in the stomach, intestines, or pancreas."]}, {"i": "MESH:D019864", "l": "Somatostatin-Secreting Cells", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5770494", "l": "LioCyx-M004", "d": []}]}
{"type": "biolink:Cell", "ic": "80.511444690059548", "identifiers": [{"i": "CL:0000217", "l": "insulating cell", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0009100", "l": "hepatic portal fibroblast", "d": ["A fibroblast located in the portal triad. Hepatic portal fibroblast are a non-parenchymal cell population located adjacent to bile duct epithelia in liver and are distinct from stellate cells. They differentiate into fibrogenic myofibroblasts during chronic injury states producing high levels of collagen."]}]}
{"type": "biolink:Cell", "ic": "75.105493098994543", "identifiers": [{"i": "CL:0002427", "l": "resting double-positive thymocyte", "d": ["A double-positive, alpha-beta thymocyte that is small and not proliferating."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5670737", "l": "Autologous Anti-FSHR CER-4-1BB/CD3zeta-expressing T-lymphocytes", "d": []}, {"i": "NCIT:C186768", "l": "Autologous Anti-FSHR CER-4-1BB/CD3zeta-expressing T-lymphocytes", "d": ["A preparation of autologous human T-lymphocytes genetically modified to express a chimeric endocrine receptor (CER) targeting the human follicle stimulating hormone receptor (FSHR) and coupled to the signaling domains of 4-1BB (CD137) and CD3 zeta, with potential immunostimulatory and antineoplastic activities. Upon administration, the autologous anti-FSHR CER-4-1BB/CD3zeta-expressing T-lymphocytes target and bind to the FSHR on FSHR-expressing tumor cell surfaces, thereby killing FSHR-expressing tumor cells. FSHR is not normally expressed in healthy non-ovarian tissue, but is present on several types of ovarian, fallopian tube, or primary peritoneal cancers."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5216192", "l": "Basophils|NCnc|Pt|Periton fld", "d": []}]}
{"type": "biolink:Cell", "ic": "92.728541327098611", "identifiers": [{"i": "UMLS:C1515019", "l": "Subependymal Cell", "d": []}, {"i": "NCIT:C41452", "l": "Subependymal Cell", "d": ["A neuroepithelial cell that is situated just beneath the ependyma, which is the lining membrane of the ventricles of the brain and of the central canal of the spinal cord."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5707892", "l": "Olitresgene Autoleucel", "d": []}, {"i": "NCIT:C188588", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0009050", "l": "B cell of anorectum", "d": ["A B cell that is located in the anorectum."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:4033028", "l": "diffuse bipolar 2 cell", "d": ["An OFF diffuse bipolar cell that predominantly connects to ON parasol cells and lateral amacrine cells. This cell contains a large number of synaptic ribbons and a small axon arbor area."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5770477", "l": "ICG-136", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5221135", "l": "Plasma cells.monotypic.S phase", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1276851", "l": "Structure of parathyroid wasserhelle cell", "d": []}, {"i": "SNOMEDCT:177629009", "d": []}]}
{"type": "biolink:Cell", "ic": "71.786315444102826", "identifiers": [{"i": "UMLS:C1515967", "l": "Anaplastic Large T-Lymphocyte", "d": []}, {"i": "NCIT:C37017", "l": "Anaplastic Large T-Lymphocyte", "d": []}]}
{"type": "biolink:Cell", "ic": "75.58416670140862", "identifiers": [{"i": "CL:0000357", "l": "stratified epithelial stem cell", "d": []}]}
{"type": "biolink:Cell", "ic": "89.347505587204751", "identifiers": [{"i": "CL:0002210", "l": "red muscle cell", "d": ["A slow muscle cell that contains high levels of myoglobin and oxygen storing proteins giving the cell a red appearance."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5421800", "l": "RAPA-501-Allo", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5163682", "l": "Erythrocyte clumps | Urine | Urinalysis", "d": []}]}
{"type": "biolink:Cell", "ic": "69.388382942757389", "identifiers": [{"i": "CL:0000040", "l": "monoblast", "d": ["A myeloid progenitor cell committed to the monocyte lineage. This cell is CD11b-positive, has basophilic cytoplasm, euchromatin, and the presence of a nucleolus."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2350249", "l": "Hemogenic Endothelial Cells", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157367", "l": "CD2 blasts | XXX | Cell markers", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5173497", "l": "Mononuclear cells | Pericardial fluid | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "ic": "77.944915021140389", "identifiers": [{"i": "UMLS:C1522060", "l": "Epithelioid Melanoma Cell", "d": []}, {"i": "NCIT:C36872", "l": "Epithelioid Melanoma Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1709635", "l": "Precursor Adenohypophysial Cell", "d": []}, {"i": "NCIT:C45957", "l": "Precursor Adenohypophysial Cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5170946", "l": "Leukocytes | Vitreous fluid | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "ic": "86.236661114203869", "identifiers": [{"i": "CL:0000904", "l": "central memory CD4-positive, alpha-beta T cell", "d": ["CD4-positive, alpha-beta memory T cell with the phenotype CCR7-positive, CD127-positive, CD45RA-negative, CD45RO-positive, and CD25-negative."]}]}
{"type": "biolink:Cell", "ic": "88.140761698499901", "identifiers": [{"i": "CL:4030002", "l": "effector memory CD45RA-positive, alpha-beta T cell, terminally differentiated", "d": ["An alpha-beta memory T cell with the phenotype CD45RA-positive."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2333944", "l": "Type PP enteroendocrine cell", "d": []}]}
{"type": "biolink:Cell", "ic": "84.75972595860604", "identifiers": [{"i": "UMLS:C1711279", "l": "Neoplastic Parathyroid Gland Oncocyte", "d": []}, {"i": "NCIT:C48272", "l": "Neoplastic Parathyroid Gland Oncocyte", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C2347293", "l": "Mononucleated Blood Cell", "d": []}, {"i": "NCIT:C73123", "l": "Mononucleated Blood Cell", "d": ["A mixture of cells possessing a single nucleus, including monocytes and lymphocytes; blood leukocytes from which granulocytes have been separated and removed."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1518312", "l": "Nevus Cell A-Type", "d": []}, {"i": "NCIT:C36864", "l": "Nevus Cell A-Type", "d": []}]}
{"type": "biolink:Cell", "ic": "85.457082654197222", "identifiers": [{"i": "CL:0000432", "l": "reticular cell", "d": ["A fibroblast that synthesizes collagen and uses it to produce reticular fibers, thus providing structural support. Reticular cells are found in many organs, including the spleen, lymph nodes and kidneys. Subtypes of reticular cells include epithelial, mesenchymal, and fibroblastic reticular cells. Fibroblastic reticular cells are involved in directing B cells and T cells to specific regions within a tissue, whereas epithelial and mesenchymal reticular cells are associated with certain areas of the brain."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:4033012", "l": "smooth muscle cell of large intestine smooth muscle longitudinal layer", "d": ["A(n) smooth muscle cell that is part of a(n) large intestine smooth muscle longitudinal layer."]}]}
{"type": "biolink:Cell", "ic": "90.82444074280258", "identifiers": [{"i": "CL:0015000", "l": "cranial motor neuron", "d": ["Motor neuron that innervate muscles that control eye, jaw, and facial movements of the vertebrate head and parasympathetic neurons that innervate certain glands and organs."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5571713", "l": "Transitional cells.deep|Urine/Urine sed", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2717770", "l": "Germ Cells, Plant", "d": []}, {"i": "MESH:D055993", "l": "Germ Cells, Plant", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5177622", "l": "Platelets | Plasma | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "ic": "92.728541327098611", "identifiers": [{"i": "UMLS:C1708875", "l": "Malignant Epithelioid Smooth Muscle Cell", "d": []}, {"i": "NCIT:C49127", "l": "Malignant Epithelioid Smooth Muscle Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "92.728541327098611", "identifiers": [{"i": "CL:0002323", "l": "amniocyte", "d": ["A cell of a fetus which is suspended in the amniotic fluid. Amniocytes are considered to arise from several tissues including fetal skin, the fetal urinary tract, umbilical cord, and the inner amniotic surface."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0003031", "l": "M3-ON retinal ganglion cell", "d": ["A monostratified retinal ganglion cell that has post synaptic terminals in sublaminar layer S4 and is depolarized by illumination of its receptive field center."]}]}
{"type": "biolink:Cell", "ic": "89.347505587204751", "identifiers": [{"i": "CL:0010020", "l": "cardiac glial cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5561412", "l": "allogeneic cultu kerat derm fibr mur col", "d": []}]}
{"type": "biolink:Cell", "ic": "54.051482850699472", "identifiers": [{"i": "UMLS:C1514005", "l": "Neoplastic Large Lymphocyte", "d": []}, {"i": "NCIT:C37008", "l": "Neoplastic Large Lymphocyte", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C4329669", "l": "Circulating Myeloid Cell", "d": []}, {"i": "NCIT:C129907", "l": "Circulating Myeloid Cell", "d": ["A myeloid-derived cell found in the peripheral blood."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0004215", "l": "type 5a cone bipolar cell", "d": ["A type 5 cone bipolar cell with narrowly stratified post synaptic terminals."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5706514", "l": "Autologous Anti-mesothelin T-cell Receptor Fusion Construct/PD-1:CD28 Switch Receptor-expressing T-cells TC-510", "d": []}, {"i": "NCIT:C188805", "d": []}]}
{"type": "biolink:Cell", "ic": "84.75972595860604", "identifiers": [{"i": "CL:0000474", "l": "pericardial nephrocyte", "d": ["An insect renal cell that filters hemolymph and is found with other pericardial nephrocytes in two rows flanking the dorsal vessel."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "MESH:D000090002", "l": "Stromal Vascular Fraction", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4263664", "l": "Lymphocyte T-cell & B-cell & Natural killer subsets", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0000920", "l": "CD8-positive, CD28-negative, alpha-beta regulatory T cell", "d": ["CD8-positive, alpha-beta positive regulatory T cell with the phenotype CD28-negative and FoxP3-positive."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C3899239", "l": "Exhausted T-Cell", "d": []}, {"i": "NCIT:C120000", "l": "Exhausted T-Cell", "d": ["An effector T-lymphocyte that is losing or has lost the ability to kill virally infected cells. T-cell exhaustion occurs during infections with high viral loads and/or prolonged duration. These T-lymphocytes undergo a gradual phenotype change and in the final stage they are unable to mount a T-cell antiviral response and are highly susceptible to apoptosis."]}]}
{"type": "biolink:Cell", "ic": "86.236661114203869", "identifiers": [{"i": "CL:4023083", "l": "chandelier cell", "d": ["An interneuron that selectively innervates the axon initial segment of pyramidal cells. Their local axonal clusters are formed by high-frequency branching at shallow angles, often ramifying around, above or below their somata with a high bouton density. The characteristic terminal portions of the axon form short vertical rows of boutons, resembling a chandelier. Chandelier cells can be multipolar or bitufted."]}]}
{"type": "biolink:Cell", "ic": "88.140761698499901", "identifiers": [{"i": "UMLS:C1882056", "l": "Neoplastic Leutein Cell", "d": []}, {"i": "NCIT:C61430", "l": "Neoplastic Leutein Cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0487179", "l": "Oval macrocyte", "d": []}, {"i": "SNOMEDCT:117170009", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0000686", "l": "cerebrospinal fluid secreting cell", "d": ["A columnar/cuboidal epithelial cell that secretes cerebrospinal fluid."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:4023114", "l": "calyx vestibular afferent neuron", "d": ["A vestibular afferent neuron which posseses a unique postsynaptic terminal, the calyx, which completely covers the basolateral walls of type I hair cells and receives input from multiple ribbon synapses."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1440382", "l": "Cells.cytoplasmic Ig mu", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5181334", "l": "Spermatozoa | Semen | Fertility testing", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002197", "l": "inactive chief cell of parathyoid gland", "d": ["A parathyroid chief cell that is not actively secreting hormone. Contains small Golgi complexes with only a few grouped vesicles and membrane-bound secretory granules; glycogen and many lipofuscin granules abound but sacs of granular endoplasmic reticulum are rare and dispersed. In normal humans, inactive chief cells out number active chief cells in a ratio of 3-5:1."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1184139", "l": "Myoepithelial cell of secondary lactiferous duct", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:2000090", "l": "dentate gyrus of hippocampal formation stellate cell", "d": ["Any stellate cell that is part of a dentate gyrus of hippocampal formation."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1519720", "l": "Type I Epithelial Receptor Cell", "d": []}, {"i": "NCIT:C33824", "l": "Type I Epithelial Receptor Cell", "d": ["A dark cell found in taste buds. It is rich in free ribosomes, tubular RER and has large dense granules and exhibits AbH immunoreactivity."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1254548", "l": "Polychromatocyte", "d": []}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "CL:0000484", "l": "connective tissue type mast cell", "d": ["Mast cell subtype whose granules contain both the serine proteases tryptase and chymase. These cells are primarily found in connective tissue, such as the peritoneal cavity, skin, and intestinal submucosa. Their development is T-cell independent."]}]}
{"type": "biolink:Cell", "ic": "90.82444074280258", "identifiers": [{"i": "UMLS:C0935440", "l": "Cuboidal cell", "d": []}, {"i": "NCIT:C13157", "l": "Cuboidal Cell", "d": ["A cube-shaped epithelial cell. Because a cuboidal cell has a relatively large cytoplasmic volume, it can undertake more complex functions such as absorption and secretion. Most glandular secretory cells are cuboidal epithelial cells and the ducts of most exocrine glands and kidney tubules are lined by cuboidal cells."]}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "CL:0002336", "l": "buccal mucosa cell", "d": ["An endothelial cell that lines the oral cavitiy including the mucosa of the gums, the palate, the lip, and the cheek."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5555777", "l": "Autologous Anti-B7-H3 CAR T Cells", "d": []}, {"i": "NCIT:C179567", "l": "Autologous Anti-B7-H3 CAR T Cells", "d": ["A preparation of autologous T-lymphocytes that have been genetically engineered to express a chimeric antigen receptor (CAR) targeting the immunoregulatory protein B7-homologue 3 (B7-H3, CD276) and containing, as of yet undisclosed co-stimulatory signaling domains, with potential immunostimulating and antineoplastic activities. Upon infusion back into the patient, autologous anti-B7-H3 CAR T cells target and bind to B7-H3-expressing tumor cells, thereby inducing selective toxicity in B7-H3-expressing tumor cells. B7-H3, a type I transmembrane protein and a member of the B7 co-stimulatory protein superfamily, is overexpressed on certain tumor cell types and on various immune cells. It is a negative regulator of the T-cell activation and its overexpression plays a key role in tumor cell invasion and metastasis."]}]}
{"type": "biolink:Cell", "ic": "92.728541327098611", "identifiers": [{"i": "CL:1001009", "l": "kidney efferent arteriole cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4246478", "l": "Diencephalic neural crest cell", "d": []}]}
{"type": "biolink:Cell", "ic": "83.552982069901191", "identifiers": [{"i": "UMLS:C1881408", "l": "Lipid-Rich Neoplastic Spindle Cell", "d": []}, {"i": "NCIT:C61424", "l": "Lipid-Rich Neoplastic Spindle Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "78.185623981295834", "identifiers": [{"i": "CL:0002068", "l": "Purkinje myocyte", "d": ["Specialized cardiac myocyte that is subendocardially interspersed with the regular cardiac muscle cell. They are uninucleate cylindrical cells, associated end-to-end in long rows, continue from the node to the atrioventricular bundle; relatively short compared to ordinary myocytes but are nearly twice their diameter."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1183326", "l": "Mesothelial cell of parietal peritoneum", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4708585", "l": "Technetium (99m-Tc) labeled granulocytes", "d": []}, {"i": "SNOMEDCT:768885006", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0596889", "l": "Mauthner's neuron", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5401594", "l": "Placental Mesenchymal Stem Cells", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5216214", "l": "Erythrocytes|NCnc|Pt|Dial fld prt", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0333769", "l": "Vacuolated fibers", "d": []}, {"i": "SNOMEDCT:71272000", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0007022", "l": "micropylar cell", "d": ["A specialized pore forming cell of the follicle, located adjacent to the animal pole of the oocyte. The micropylar cell makes the single micropyle (pore) through the chorion through which the sperm fertilizes the egg."]}]}
{"type": "biolink:Cell", "ic": "92.728541327098611", "identifiers": [{"i": "CL:1000849", "l": "kidney distal convoluted tubule epithelial cell", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5418015", "l": "Autologous BCMA-targeted CAR T Cells CC-98633", "d": []}, {"i": "NCIT:C173699", "l": "Autologous BCMA-targeted CAR T Cells CC-98633", "d": ["A preparation of autologous T-lymphocytes that have been genetically modified to express a chimeric antigen receptor (CAR) specific for the B-cell maturation antigen (BCMA; tumor necrosis factor receptor superfamily member 17; TNFRSF17), with potential immunostimulating and antineoplastic activities. Upon administration, autologous BCMA-targeted CAR T cells CC-98633 specifically recognize and kill BCMA-expressing tumor cells. BCMA, a tumor specific antigen and a receptor for both a proliferation-inducing ligand (APRIL) and B-cell activating factor (BAFF), is a member of the tumor necrosis factor (TNF) receptor superfamily and plays a key role in plasma cell survival; it is found on the surfaces of plasma cells and overexpressed on malignant plasma cells."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1440267", "l": "CD19+Kappa+ cell", "d": []}, {"i": "SNOMEDCT:732277006", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0001075", "l": "KLRG1-positive innate lymphoid cell, human", "d": ["An innate lymphoid cell in the human with the phenotype KLRG1-positive that is a precusor for ILC2 cells."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1440281", "l": "Cells.CD3+CD4+CD45RO+CD45RA-", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5419893", "l": "Autologous UCD19 CAR T Cells", "d": []}, {"i": "NCIT:C172841", "l": "Autologous UCD19 CAR T Cells", "d": ["A preparation of autologous peripheral blood lymphocytes (PBLs) that have been transduced with a lentiviral vector to express a chimeric antigen receptor (CAR) targeting the tumor-associated antigen (TAA) CD19, with potential immunostimulating and antineoplastic activities. Upon transfusion, the autologous UCD19 CAR T-cells recognize and bind to CD19-expressing tumor cells, thereby selectively lysing CD19-expressing tumor cells. CD19, a B-cell-specific cell surface antigen is overexpressed in B-cell lineage malignancies."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C4724740", "l": "CMV/EBV/ADV/BKV-specific Cytotoxic T Lymphocytes", "d": []}, {"i": "NCIT:C150381", "l": "CMV/EBV/ADV/BKV-specific Cytotoxic T Lymphocytes", "d": ["A population of cytotoxic T-lymphocytes (CTLs) specifically reactive to cytomegalovirus (CMV), Epstein-Barr virus (EBV), adenovirus (ADV) and BK virus (BKV), with potential antiviral and protective activities. T-cells derived from peripheral blood mononuclear cells (PBMCs) are exposed to and activated by dendritic cells (DCs) that are loaded with specific peptides from CMV, EBV, ADV and BKV. Upon infusion of the CMV/EBV/ADV/BKV-specific CTLs, these lymphocytes target and cause lysis of CMV-, EBV-, ADV- and/or BKV-infected cells and may prevent infection and complications from CMV-, EBV-, ADV- and BKV-driven viral diseases. Opportunistic infections caused by these viruses are often seen in immunosuppressed patients."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1955926", "l": "Pro-B Lymphocytes", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5426675", "l": "Monocytes.programmed cell death ligand 1", "d": []}]}
{"type": "biolink:Cell", "ic": "74.240948556675605", "identifiers": [{"i": "CL:0000174", "l": "steroid hormone secreting cell", "d": []}]}
{"type": "biolink:Cell", "ic": "75.751739371353352", "identifiers": [{"i": "CL:0000169", "l": "type B pancreatic cell", "d": ["A cell that secretes insulin and is located towards the center of the islets of Langerhans."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002596", "l": "smooth muscle cell of the carotid artery", "d": ["Smooth muscle cell of the carotid artery."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:1000344", "l": "paneth cell of epithelium proper of small intestine", "d": ["A Paneth cell that is part of the epithelium proper of small intestine."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002602", "l": "annulus pulposus cell", "d": []}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "CL:0002662", "l": "luminal cell of lactiferous duct", "d": ["A luminal epithelial cell of the lactiferous duct. This cuboidal epithelial cell expresses keratin-18 and is estrogen-receptor alpha positive."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1978414", "l": "Blast cell positive for CD22 antigen", "d": []}, {"i": "SNOMEDCT:724266008", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157672", "l": "CD8+CD95+ cells | Blood | Cell markers", "d": []}]}
{"type": "biolink:Cell", "ic": "72.370703631459492", "identifiers": [{"i": "UMLS:C1518268", "l": "Neoplastic Neuroblast", "d": []}, {"i": "NCIT:C37145", "l": "Neoplastic Neuroblast", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0684117", "l": "prokaryoblast", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5163451", "l": "Eosinophils | XXX | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "CL:0002294", "l": "type-1 epithelial cell of thymus", "d": ["An epithelial cell with a well defined Golgi apparatus that makes up the continuous layer of cells bordering the thymic tissue beneath the capsule."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5554955", "l": "Autologous Natural Killer Cells SNK01", "d": []}, {"i": "NCIT:C178330", "l": "Autologous Natural Killer Cells SNK01", "d": ["A preparation of autologous, ex-vivo expanded and activated natural killer (NK) cells, with potential cytolytic and antineoplastic activities. Upon infusion back into the patient, the autologous NK cells SNK01 may lyse cancer cells. These cells also secrete pro-inflammatory cytokines, which further stimulate an anti-tumor immune response."]}]}
{"type": "biolink:Cell", "ic": "74.240948556675605", "identifiers": [{"i": "CL:0002676", "l": "neural crest derived neuroblast", "d": ["A neuroblast derived from a neural crest cell."]}]}
{"type": "biolink:Cell", "ic": "90.82444074280258", "identifiers": [{"i": "CL:1000313", "l": "gastric goblet cell", "d": ["A goblet cell that is part of the epithelium of stomach."]}]}
{"type": "biolink:Cell", "ic": "80.869303025598512", "identifiers": [{"i": "CL:0000065", "l": "ependymal cell", "d": ["A neurectoderm derived cell that lines the neural lumen."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5575123", "l": "Autologous Anti-BCMA CAR-T Cells JNJ-68284528", "d": []}]}
{"type": "biolink:Cell", "ic": "68.25778018697109", "identifiers": [{"i": "CL:0000067", "l": "ciliated epithelial cell", "d": ["An epithelial cell that has a cilia."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5447425", "l": "Differentiated Anti-BCMA Autologous CAR T Cells ARI0002h", "d": []}, {"i": "NCIT:C176769", "l": "Differentiated Anti-BCMA Autologous CAR T Cells ARI0002h", "d": ["A preparation of adult human differentiated autologous T-lymphocytes that have been ex vivo expanded and transduced with a genetically-engineered lentiviral vector (LV) expressing a chimeric antigen receptor (CAR) specific for the tumor-associated antigen (TAA) human B-cell maturation antigen (BCMA; tumor necrosis factor receptor superfamily member 17; TNFRSF17) fused to the co-stimulatory domain of 4-1BB (CD137) and the CD3-zeta (CD3z) T-cell signaling domain, with potential immunostimulating and antineoplastic activities. Upon administration, the differentiated anti-BCMA autologous CAR T cells ARI0002h specifically recognize and induce selective toxicity in BCMA-expressing tumor cells. BCMA, a tumor-specific antigen and a receptor for both a proliferation-inducing ligand (APRIL) and B-cell activating factor (BAFF), is a member of the tumor necrosis factor receptor superfamily (TNFRSF) and plays a key role in plasma cell survival. BCMA is found on the surfaces of plasma cells and overexpressed on malignant plasma cells."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4522890", "l": "T Lymphocytes, Cultured, Autologous, Genetically-modified", "d": []}]}
{"type": "biolink:Cell", "ic": "79.541110464886842", "identifiers": [{"i": "CL:0008039", "l": "lower motor neuron", "d": ["The motor neurons of vertebrates that directly innervate skeletal muscles. They receive input from upper motor neurons."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2335330", "l": "Set of cholinergic cells of accumbens nucleus [Ch2]", "d": []}]}
{"type": "biolink:Cell", "ic": "83.552982069901191", "identifiers": [{"i": "CL:0005022", "l": "vascular lymphangioblast", "d": ["Lymphatic progenitor cells, derived from the veins, that give rise to lymphatic endothelial cells."]}]}
{"type": "biolink:Cell", "ic": "46.451512918952034", "identifiers": [{"i": "CL:0000338", "l": "neuroblast (sensu Nematoda and Protostomia)", "d": ["A neural precursor of the central nervous system."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1179760", "l": "Epithelial cell of appendix", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C4744787", "l": "Alpha/Beta T-Lymphocyte", "d": []}, {"i": "NCIT:C156387", "l": "Alpha/Beta T-Lymphocyte", "d": ["A mature T-cell that expresses a T-cell receptor complex comprised of the highly variable alpha and beta chains complexed with the invariant CD3 antigen complex and plays a primary role in adaptive immunity."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157538", "l": "CD4+CD25+CD45RA+CD127Low+ cells | Blood | Cell markers", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0883467", "l": "Cells.CD11+CD20+", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1267888", "l": "Lymphocyte positive for both CD19 antigen and surface lambda immunoglobulin light chain", "d": []}, {"i": "SNOMEDCT:117564007", "d": []}]}
{"type": "biolink:Cell", "ic": "89.347505587204751", "identifiers": [{"i": "CL:0008011", "l": "skeletal muscle satellite stem cell", "d": ["A skeletal muscle satellite cell that divides by stem cell division.  A proportion of this population undergoes symmetric stem cell division, producing two skeletal muscle satellite stem cells. The rest undergo asymmetric stem cell division - retaining their identity while budding off a daughter cell that differentiates into an adult skeletal muscle myoblast."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4477473", "l": "human cord blood hematopoietic progenitor cell 500000000 in 25 mL INTRAVENOUS INJECTION, SUSPENSION [CLEVECORD]", "d": []}]}
{"type": "biolink:Cell", "ic": "73.721563224321088", "identifiers": [{"i": "UMLS:C1516399", "l": "Cerebriform Lymphocyte", "d": []}, {"i": "NCIT:C39621", "l": "Cerebriform Lymphocyte", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5705651", "l": "NEURONATA-R", "d": []}]}
{"type": "biolink:Cell", "ic": "71.335885432862128", "identifiers": [{"i": "UMLS:C1709167", "l": "Neoplastic Cartilage Cell", "d": []}, {"i": "NCIT:C48696", "l": "Neoplastic Cartilage Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0001202", "l": "CD86-positive plasmablast", "d": ["A plasmablast that is CD86-positive."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4510925", "l": "Blast cell positive for CD20 antigen", "d": []}, {"i": "SNOMEDCT:725174006", "d": []}]}
{"type": "biolink:Cell", "ic": "82.076046914303362", "identifiers": [{"i": "UMLS:C1518310", "l": "Neutrophil with Pseudo Pelger-Huet Nucleus", "d": []}, {"i": "NCIT:C36724", "l": "Neutrophil with Pseudo Pelger-Huet Nucleus", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157459", "l": "CD3+CD8+CD27+CD62L+ cells | Blood | Cell markers", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C4287595", "l": "CD16+ CD56+ CD69+ Lymphocyte", "d": []}, {"i": "NCIT:C128465", "l": "CD16+ CD56+ CD69+ Lymphocyte", "d": ["A population of activated lymphocytes that express CD16 (Fc-gamma receptor III), CD56 (neural cell adhesion molecule 1) and CD69 (early activation antigen CD69), which is mainly comprised of natural killer cells with an activated phenotype."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157537", "l": "CD4+CD25+ cells | Blood | Cell markers", "d": []}]}
{"type": "biolink:Cell", "ic": "83.023198044254755", "identifiers": [{"i": "CL:0002222", "l": "vertebrate lens cell", "d": ["A cell comprising the transparent, biconvex body separating the posterior chamber and vitreous body, and constituting part of the refracting mechanism of the mammalian eye."]}]}
{"type": "biolink:Cell", "ic": "92.728541327098611", "identifiers": [{"i": "CL:0002462", "l": "adipose dendritic cell", "d": ["A F4/80-negative dendritic cell located in adipose tissue."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5173498", "l": "Mononuclear cells | Peritoneal fluid | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5171673", "l": "Lymphocytes clefted | Blood | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "ic": "79.246894609297499", "identifiers": [{"i": "UMLS:C1881559", "l": "Malignant Hobnail Cell", "d": []}, {"i": "NCIT:C61543", "l": "Malignant Hobnail Cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2328196", "l": "Sympathetic preganglionic neuron", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5708040", "l": "Autologous Anti-GD2/Anti-PSMA 4SCAR-expressing Bispecific T-cells", "d": []}, {"i": "NCIT:C188800", "d": []}]}
{"type": "biolink:Cell", "ic": "75.751739371353352", "identifiers": [{"i": "CL:0001082", "l": "immature innate lymphoid cell", "d": ["An innate lyphoid cell with an immature phenotype."]}]}
{"type": "biolink:Cell", "ic": "92.728541327098611", "identifiers": [{"i": "CL:1001006", "l": "kidney afferent arteriole cell", "d": []}]}
{"type": "biolink:Cell", "ic": "63.752564210074205", "identifiers": [{"i": "UMLS:C1513995", "l": "Neoplastic Large B-Lymphocyte", "d": []}, {"i": "NCIT:C37013", "l": "Neoplastic Large B-Lymphocyte", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4042840", "l": "RAW 264.7 Cells", "d": []}, {"i": "MESH:D000067996", "l": "RAW 264.7 Cells", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5216231", "l": "Leukocytes|NCnc|Pt|Bld", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:4033003", "l": "myoepithelial cell of bronchus submucosal gland", "d": ["A(n) myoepithelial cell that is part of a(n) bronchus submucosal gland."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5761765", "l": "Activated natural killer cell therapy", "d": []}]}
{"type": "biolink:Cell", "ic": "87.120474278337809", "identifiers": [{"i": "CL:1000274", "l": "trophectodermal cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0333817", "l": "Hyposegmented leukocyte", "d": []}, {"i": "SNOMEDCT:42997003", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5708220", "l": "Anti-CD19/Anti-CD70 4SCAR-expressing Bispecific T-cells", "d": []}, {"i": "NCIT:C189058", "d": []}]}
{"type": "biolink:Cell", "ic": "67.937454763326897", "identifiers": [{"i": "CL:0000990", "l": "conventional dendritic cell", "d": ["Conventional dendritic cell is a dendritic cell that is CD11c-high."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1440311", "l": "Cells.CD42d", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1328049", "l": "LMP2A-Specific Cytotoxic T-Lymphocytes", "d": []}, {"i": "NCIT:C62784", "l": "LMP2A-Specific Cytotoxic T-Lymphocytes", "d": ["A preparation of cytotoxic T-lymphocytes (CTL), specifically reactive to Epstein-Barr virus (EBV) latent membrane protein-2A (LMP2A), with potential antineoplastic activity. T-lymphocytes are exposed ex vivo to dendritic cells (DCs) transfected with a replication-deficient adenovirus encoding EBV LMP2A. Subsequently, LMP2A-specific CTLs are exposed to EBV infected cells transfected with adenovirus encoding LMP2A, thereby further stimulating CTLs. Administered to patients with EBV-positive tumors, LMP2A-specific CTLs target LMP2A-positive cells, resulting in cell lysis and inhibition of cancer cell proliferation. EBV LMP2A may be expressed in various malignancies, including nasopharyngeal carcinoma and Hodgkin and non-Hodgkin lymphomas."]}]}
{"type": "biolink:Cell", "ic": "72.269651791985453", "identifiers": [{"i": "UMLS:C0085983", "l": "Cell Line, Tumor", "d": []}, {"i": "NCIT:C20313", "l": "Tumor Cell Line", "d": []}, {"i": "MESH:D045744", "l": "Cell Line, Tumor", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C3896611", "l": "ROR1 CAR-specific Autologous T-Lymphocytes", "d": []}, {"i": "NCIT:C117237", "l": "ROR1 CAR-specific Autologous T-Lymphocytes", "d": ["A mixture of two T-lymphocyte preparations expressing a chimeric antigen receptor (CAR) consisting of an anti-receptor tyrosine kinase-like orphan receptor 1 (ROR1) single chain variable fragment (scFv) fused to either the co-stimulatory signaling domain cluster of differentiation 28 (CD28), and the zeta chain of the T-cell receptor (TCR)/CD3 complex (CD3-zeta) (ROR1CD28zeta), or the co-stimulatory signaling domain cluster of differentiation 137 (CD137; 4-1BB), and the zeta chain of the T-cell receptor (TCR)/CD3 complex (CD3-zeta) (ROR1CD137zeta), with potential immunomodulating and antineoplastic activities. Upon simultaneous administration of the two T-lymphocyte populations ROR1CD28zeta and ROR1CD137zeta , the ROR1 CAR-specific autologous T-lymphocytes are directed to tumor cells expressing ROR1, which may result in a selective toxicity against, and lysis of ROR1-expressing tumor cells. CD28, a T-cell surface-associated co-stimulatory molecule, is required for full T-cell activation, proliferation, and survival. The 4-1BB co-stimulatory molecule signaling domain enhances activation and signaling after recognition of ROR1. ROR1, also known as neurotrophic tyrosine kinase, receptor-related 1, is expressed during embryogenesis and by certain leukemias."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1515146", "l": "TE03", "d": []}, {"i": "NCIT:C20296", "l": "TE03", "d": ["Provider: Technion University, Haifa, Israel. No information from provider. This cell line meets the criteria for the use of human embryonic stem cells by federally funded researchers."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5554965", "l": "Autologous Anti-HER2 CAR T-cells CCT303-406", "d": []}, {"i": "NCIT:C178340", "l": "Autologous Anti-HER2 CAR T-cells CCT303-406", "d": ["A preparation of autologous T-lymphocytes that have been genetically modified to express a chimeric antigen receptor (CAR) targeting the tumor-associated antigen (TAA) human epidermal growth factor 2 (HER2; ErbB2; HER-2), with potential immunostimulating and antineoplastic activities. Upon administration, autologous anti-HER2 CAR T-cells CCT303-406 target and bind to HER2-expressing tumor cells, thereby inducing selective toxicity in HER2-expressing tumor cells. HER2 is overexpressed in a variety of cancer cell types and is associated with increased tumor cell proliferation."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1510958", "l": "Atypical Lobular Epithelial Cell", "d": []}, {"i": "NCIT:C36885", "l": "Atypical Lobular Epithelial Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C0221283", "l": "Drepanocyte (cell)", "d": []}, {"i": "NCIT:C36717", "l": "Sickle Cell", "d": []}, {"i": "SNOMEDCT:49938009", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0521392", "l": "Peripheral motor neuron", "d": []}, {"i": "SNOMEDCT:18249007", "d": []}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "CL:0002246", "l": "peripheral blood stem cell", "d": ["A hematopoeitic stem cell found in the blood. Normally found in very limited numbers in the peripheral circulation (less than 0.1% of all nucleated cells)."]}]}
{"type": "biolink:Cell", "ic": "71.602448984170266", "identifiers": [{"i": "UMLS:C1709161", "l": "Neoplastic Adenohypophysial Cell", "d": []}, {"i": "NCIT:C45963", "l": "Neoplastic Adenohypophysial Cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4322826", "l": "CD16+CD56+ T lymphocyte", "d": []}]}
{"type": "biolink:Cell", "ic": "55.464775526347672", "identifiers": [{"i": "CL:0000084", "l": "T cell", "d": ["A type of lymphocyte whose defining characteristic is the expression of a T cell receptor complex."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C3496262", "l": "Ats catecholamine cells", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:1000359", "l": "microfold cell of epithelium proper of appendix", "d": ["A M cell that is part of the epithelium proper of appendix."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0000180", "l": "estradiol secreting cell", "d": ["A steroid hormone secreting cell that secretes estradiol."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5220592", "l": "Histiocytes|Urine/Urine sed", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1519715", "l": "Type II Epithelial Receptor Cell", "d": []}, {"i": "NCIT:C33825", "l": "Type II Epithelial Receptor Cell", "d": ["A light cell found in taste buds that has large amorphous areas of cytoplasmic matrix, scarce ribosomes and RER. Most are alpha-gustducin immunoreactive, some may be AbH immunoreactive and/or PGP 9.5 immunoreactive."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C3652431", "l": "limbal stem cells, autologous", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0229641", "l": "Eosinophilic promyelocyte", "d": []}, {"i": "SNOMEDCT:4029003", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5419242", "l": "Tonogenconcel", "d": []}, {"i": "NCIT:C171656", "l": "Tonogenconcel", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0000416", "l": "polytene cell", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002505", "l": "liver CD103-negative dendritic cell", "d": ["A CD11b-positive dendritic cell that is CD11b-high, CD45-positive, MHC-II-positive and CD103-negative."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002476", "l": "bone marrow macrophage", "d": ["A tissue-resident macrophage located in the bone marrow. This cell type is B220-negative, CD3e-negative, Ly-6C-negative, CD115-positive, F4/80-positive."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0684118", "l": "Early erythroblast", "d": []}, {"i": "SNOMEDCT:115610004", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1267901", "l": "Lymphocyte positive for CD28 antigen", "d": []}, {"i": "SNOMEDCT:117572009", "d": []}]}
{"type": "biolink:Cell", "ic": "65.891564071043305", "identifiers": [{"i": "CL:0000154", "l": "protein secreting cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5708216", "l": "Anti-CD38-CAR-TCRz/4-1BB-expressing T-lymphocytes", "d": []}, {"i": "NCIT:C189049", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C3652636", "l": "technetium (99mTc) exametazime labelled cells", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1516866", "l": "Endosteal cell", "d": []}, {"i": "NCIT:C32521", "l": "Endosteal Cell", "d": ["A cell lining the medullary cavity of bone."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C4725078", "l": "Hepatitis B Virus Antigen Peptides/Hepatitis G2 Cell Protein Lysate-activated Dendritic Cells", "d": []}, {"i": "NCIT:C148495", "l": "Hepatitis B Virus Antigen Peptides/Hepatitis G2 Cell Protein Lysate-activated Dendritic Cells", "d": ["A cell-based cancer vaccine composed of autologous dendritic cells (DCs) ex vivo activated with the hepatitis B virus (HBV)-specific tumor-associated antigen (TAA) peptides derived from the patient's tumor and cell lysate proteins harvested from the immortalized human liver cancer cell line HepG2, with potential immunostimulatory and antineoplastic activities. Upon administration, the HBV peptides/HepG2 cell protein lysate-activated DCs expose the immune system to the HBV epitopes and an undefined amount of other TAAs from the HepG2 cell lysate, which may result in the induction of a specific anti-tumor cytotoxic T-lymphocyte (CTL)-mediated immune response against tumor cells expressing the HBV/HepG2 TAAs. HBV TAAs are found on HBV-positive cells and on HBV-induced hepatocellular carcinoma (HBV-HCC)."]}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "UMLS:C5554732", "l": "Malignant Epithelioid Cell with Abundant Eosinophilic Cytoplasm", "d": []}, {"i": "NCIT:C177900", "l": "Malignant Epithelioid Cell with Abundant Eosinophilic Cytoplasm", "d": ["A malignant cell resembling an epithelial cell and exhibiting abundant eosinophilic cytoplasm."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2328655", "l": "Reticular cell of splenic cord", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5700424", "l": "Autologous CD34+ HSCs Transduced with LentiGlobin BB305", "d": []}]}
{"type": "biolink:Cell", "ic": "69.453592996529309", "identifiers": [{"i": "CL:0000790", "l": "immature alpha-beta T cell", "d": ["An alpha-beta T cell that has an immature phenotype and has not completed T cell selection."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0000697", "l": "R4 photoreceptor cell", "d": []}]}
{"type": "biolink:Cell", "ic": "77.944915021140389", "identifiers": [{"i": "CL:0002465", "l": "CD11b-positive dendritic cell", "d": ["A conventional dendritic cell that expresses CD11b (ITGAM)."]}]}
{"type": "biolink:Cell", "ic": "80.869303025598512", "identifiers": [{"i": "CL:2000028", "l": "cerebellum glutamatergic neuron", "d": ["Any glutamatergic neuron that is part of a cerebellum."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1519121", "l": "SA02", "d": []}, {"i": "NCIT:C20265", "l": "SA02", "d": ["Provider: Goteborg University, Goteborg, Sweden. No information from provider. This cell line meets the criteria for the use of human embryonic stem cells by federally funded researchers."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4510885", "l": "Blast cell positive for CD13 antigen", "d": []}, {"i": "SNOMEDCT:724270000", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C4049868", "l": "Gitter Cell", "d": []}, {"i": "NCIT:C123738", "l": "Gitter Cell", "d": ["A microglial cell that is unable to phagocytose any further materials. Named for its grainy appearance, gitter cells can indicate post-infection areas that have healed."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1182668", "l": "Endo-epithelial cell of pharyngotympanic part of viscerocranial mucosa", "d": []}]}
{"type": "biolink:Cell", "ic": "76.659841615658792", "identifiers": [{"i": "CL:0000897", "l": "CD4-positive, alpha-beta memory T cell", "d": ["A CD4-positive, alpha-beta T cell that has differentiated into a memory T cell."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157543", "l": "CD4+CD45+ cells | Blood | Cell markers", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5426633", "l": "Cells.CD3-CD14+CD45+DOCK8+", "d": []}]}
{"type": "biolink:Cell", "ic": "83.552982069901191", "identifiers": [{"i": "CL:0000627", "l": "transporting cell", "d": ["A cell involved in transporting nutrients, minerals, water, gases and other chemicals between cells for a variety of purposes including conveying nutrition to other tissues, removing waste products from the tissues, conveying gases for respiration, distributing heat and repelling invasion of foreign substances."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002267", "l": "type D cell of stomach", "d": ["A type D cell found in the stomach."]}]}
{"type": "biolink:Cell", "ic": "60.180458012661006", "identifiers": [{"i": "UMLS:C0017471", "l": "Germ Cells", "d": []}, {"i": "NCIT:C12597", "l": "Germ Cell", "d": ["Gametes, also known as sex cells or germ cells, are the cells that come together during fertilization or conception in organisms that reproduce sexually.  Their genetic complement consists of a single set of unpaired chromosomes."]}, {"i": "MESH:D005854", "l": "Germ Cells", "d": []}, {"i": "SNOMEDCT:787781003", "d": []}]}
{"type": "biolink:Cell", "ic": "87.120474278337809", "identifiers": [{"i": "CL:0002355", "l": "primitive red blood cell", "d": ["A large nucleated basophilic erythrocyte found in mammalian embryos. This cell type arises from the blood islands of yolk sacs and expresses different types of hemoglobins (beta-H1, gamma-1 and zeta) than adult erythrocytes. Considered a type of erythroblast as this cell type can enucleate in circulation."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5761771", "l": "Carlecortemcel-L", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0546497", "l": "P.B. plasmoblast", "d": []}]}
{"type": "biolink:Cell", "ic": "80.869303025598512", "identifiers": [{"i": "CL:0000510", "l": "paneth cell", "d": ["An epithelial cell found in the basal part of the intestinal glands (crypts of Lieberkuhn) including the appendix. Paneth cells synthesize and secrete lysozyme and cryptdins. Numerous in the deeper parts of the intestinal crypts, particularly in the duodenum, rich in zinc, contain large acidophilic granules, with irregular apical microvilli and prominent membrane-bound vacuoles containing matrix."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:4023115", "l": "type 1 spiral ganglion neuron", "d": ["A spiral ganglion neuron that innervates inner hair cells. Type 1 spiral ganglion neurons are myelinated and bipolar."]}]}
{"type": "biolink:Cell", "ic": "89.347505587204751", "identifiers": [{"i": "UMLS:C1513984", "l": "Neoplastic Histiocyte", "d": []}, {"i": "NCIT:C36888", "l": "Neoplastic Histiocyte", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0085087", "l": "3T3 Cells", "d": []}, {"i": "MESH:D016475", "l": "3T3 Cells", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002285", "l": "type III taste bud cell", "d": ["A taste receptor cell that is characterized by morphologically identifiable synaptic contacts with the gustatory nerve fibers and expression of the synaptic membrane protein-25 (SNAP-25) and NCAM."]}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "CL:0002561", "l": "outer root sheath cell", "d": ["An epithelial cell that is part of the outer root sheath."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5707860", "l": "Vandefitemcel", "d": []}, {"i": "NCIT:C188551", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C4764271", "l": "Autologous CAR-mbIL15-Safety Switch T-cells PRGN-3005", "d": []}, {"i": "NCIT:C158533", "l": "Autologous CAR-mbIL15-Safety Switch T-cells PRGN-3005", "d": ["A preparation of autologous T-lymphocytes that have been genetically modified to co-express three transgenes using the Sleeping Beauty (SB) transposon system and include a chimeric antigen receptor (CAR) targeting an undisclosed tumor-associated antigen (TAA), a membrane-bound IL-15 (mbIL15) and a safety/kill switch, with potential immunostimulating and antineoplastic activities. Upon introduction of the autologous PRGN-3005 into the patient, the T-cells target and bind to the TAA-expressing tumor cells, thereby inducing selective toxicity in the TAA-expressing tumor cells. IL-15 is a pro-survival cytokine that is required for the maintenance of long-lived CD8+ memory T-cells and use of mbIL15 preserves T stem-cell memory (TSCM) through sustained IL-15 signaling, improves T-cell persistence and potentiates the immune response against tumor cells. The safety switch can promote selective elimination of the CAR-T cells. The SB system permits integration of the CAR, the IL-15 fusion variant and safety switch transgenes into T-cells without the need for viral vectors and accelerates the manufacturing process."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1182655", "l": "Mesothelial cell of anterior chamber of eye", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1517358", "l": "GE91", "d": []}, {"i": "NCIT:C20261", "l": "GE91", "d": ["Provider: Geron Corporation, Menlo Park, CA. No information from provider. This cell line meets the criteria for the use of human embryonic stem cells by federally funded researchers."]}]}
{"type": "biolink:Cell", "ic": "69.858950277264299", "identifiers": [{"i": "CL:0000029", "l": "neural crest derived neuron", "d": []}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "CL:1000708", "l": "ureter adventitial cell", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5206468", "l": "Autologous Anti-HLA-A*02/AFP TCRm-expressing T-cells ET140202", "d": []}, {"i": "NCIT:C162260", "l": "Autologous Anti-HLA-A*02/AFP TCRm-expressing T-cells ET140202", "d": ["A preparation of autologous T-lymphocytes that have been transduced with a lentiviral vector to express a T-cell receptor mimetic (TCRm) antibody synthesized by a proprietary phage display platform, targeting the immunogenetic human tumor-associated antigen (TAA) alpha-fetoprotein (AFP) complexed with human leukocyte antigen (HLA)-A*02 (HLA-A*02/AFP), with potential antineoplastic and immunomodulatory activities. Upon administration, the autologous anti-HLA-A*02/AFP TCRm-expressing T-cells ET140202 specifically recognize and selectively bind to AFP peptides presented by HLA-A*02. This results in cytotoxic T-lymphocyte (CTL)-mediated elimination of AFP-expressing tumor cells. AFP, an intracellularly expressed fetal glycoprotein rarely expressed in adult tissues, is overexpressed in certain tumors of endodermal origin and plays a key role in tumor cell proliferation and survival. AFP is processed into peptides and presented by class I major histocompatibility complexes (MHCs) on the surface of tumor cells."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C3896612", "l": "Tumor Antigen-reactive CD28+/CCR7+/CD27+/CD45RA- Cytotoxic T-lymphocyte", "d": []}, {"i": "NCIT:C118848", "l": "Tumor Antigen-reactive CD28+/CCR7+/CD27+/CD45RA- Cytotoxic T-lymphocyte", "d": ["A subset of rapidly expanding, tumor antigen-reactive central memory cytotoxic T-lymphocytes (CTLs) with a broad expression profile for markers of immune function (MIF), and a particular phenotype of CD28+/CCR7+/CD27+/CD45RA-. These CTLs are formed in vivo following administration of AGS-003 (an autologous, CD40L and tumor antigen RNA-transfected dendritic cell (DC) immunotherapeutic agent), secrete multiple cytokines, including interferon-gamma (IFN-g), tumor necrosis factor-alpha (TNF-a), and interleukin-2 (IL-2), and cause cell lysis. These antigen-reactive, CD28+/CCR7+/CD27+/CD45RA- CTLs, and the phenotype changes in the patient's peripheral blood CTL pool, can be used as a marker to evaluate a patient's immune response against the administered immunotherapeutic agent AGS-003."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C3831438", "l": "Autologous Cultured Acute Myeloid Leukemia-specific Cytotoxic T Lymphocytes", "d": []}, {"i": "NCIT:C111996", "l": "Autologous Cultured Acute Myeloid Leukemia-specific Cytotoxic T Lymphocytes", "d": ["A preparation of cytotoxic, autologous acute myelogenous leukemia (AML)-reactive T lymphocytes (CTL), with potential immunomodulating and antineoplastic activities. The autologous cultured AML-specific CTLs are prepared using a specific AML-CTL culture method. Autologous peripheral blood lymphocytes are taken from an AML patient and the autologous AML blasts are treated with granulocyte macrophage colony-stimulating factor (GM-CSF) and interleukin 4 (IL-4), both of which promote ex vivo differentiation of AML blasts into dendritic cells (DCs). In the same culture, T cells are treated and activated by low-dose interleukin 2 (IL-2), and expanded using anti-CD3. This results in cultured AML-reactive CTLs which are administered back into the patient after autologous hematopoietic stem cell transplant (AHSCT). The autologous cultured AML-specific CTLs may eradicate residual AML cells."]}]}
{"type": "biolink:Cell", "ic": "88.140761698499901", "identifiers": [{"i": "CL:1001021", "l": "kidney loop of Henle descending limb epithelial cell", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:1000697", "l": "kidney interstitial suppressor macrophage", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5763098", "l": "ALLOGENIC ADIPOSE DERIVED MESENCHYMAL STEM CELLS (MSCS) EXOSOMES", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0946057", "l": "Erythrocytes.CD55", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1182691", "l": "Epithelial cell of gland of skin", "d": []}]}
{"type": "biolink:Cell", "ic": "89.347505587204751", "identifiers": [{"i": "UMLS:C1707838", "l": "EBV-Transformed Late Germinal Center/Post-Germinal Center B-Lymphocyte", "d": []}, {"i": "NCIT:C45694", "l": "EBV-Transformed Late Germinal Center/Post-Germinal Center B-Lymphocyte", "d": ["A B-lymphocyte that has been activated to be receptive to Epstein Barr virus and is found in the area of a lymph nodule containing aggregations of actively proliferating lymphocytes."]}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "CL:1000415", "l": "epithelial cell of gallbladder", "d": ["An epithelial cell that is part of the gallbladder."]}]}
{"type": "biolink:Cell", "ic": "80.511444690059548", "identifiers": [{"i": "CL:1000454", "l": "kidney collecting duct epithelial cell", "d": ["An epithelial cell that is part of the collecting duct of renal tubule."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:1000492", "l": "mesothelial cell of parietal pleura", "d": ["A mesothelial cell that is part of the parietal pleura."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C3829190", "l": "MART-1 Reactive CD8+ T-lymphocytes", "d": []}, {"i": "NCIT:C111683", "l": "MART-1 Reactive CD8+ T-lymphocytes", "d": ["Human CD8-positive T-lymphocytes that are engineered to recognize melanoma tumor associated antigen MART-1 (Melanoma Antigen Recognized by T cells, also called Melan-A) in a human leukocyte antigen (HLA)-A2-restricted manner, with potential antineoplastic activity. Human peripheral blood lymphocytes (PBLs) are isolated from a melanoma patient, exposed to the MART-1:27-35(27L) peptide and MART-1 specific T-lymphocytes are isolated and expanded. Upon infusion, these lymphocytes recognize and exert a cytotoxic T-cell-mediated immune response against MART-1-expressing melanoma cells. The synthetic MART-1:27-35 HLA-A2-restricted peptide has an amino acid substitution, leucine to alanine at position 27, to increase its immunogenicity."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2336943", "l": "Transitional myocyte of interatrial septum", "d": []}]}
{"type": "biolink:Cell", "ic": "83.023198044254755", "identifiers": [{"i": "CL:0000438", "l": "luteinizing hormone secreting cell", "d": ["A peptide hormone secreting cell pituitary that produces luteinizing hormone."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5448048", "l": "UWC 19", "d": []}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "CL:0001052", "l": "CD8-positive, CXCR3-negative, CCR6-negative, alpha-beta T cell", "d": ["A CD8-positive, alpha-beta T cell that has the phenotype CXCR3-negative, CCR6-negative."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5690872", "l": "L929 Cells", "d": []}]}
{"type": "biolink:Cell", "ic": "89.347505587204751", "identifiers": [{"i": "UMLS:C1709164", "l": "Neoplastic Blast Coexpressing Myeloid and Lymphoid Lineage Antigens", "d": []}, {"i": "NCIT:C42875", "l": "Neoplastic Blast Coexpressing Myeloid and Lymphoid Lineage Antigens", "d": []}]}
{"type": "biolink:Cell", "ic": "41.400597759832046", "identifiers": [{"i": "CL:0011115", "l": "precursor cell", "d": ["A cell that, by division or terminal differentiation, can give rise to other cell types."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1517641", "l": "KA41 cell line", "d": []}, {"i": "NCIT:C20271", "l": "KA41", "d": ["Provider: Karolinska Institute, Stockholm, Sweden. No information from provider. This cell line meets the criteria for the use of human embryonic stem cells by federally funded researchers."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1517815", "l": "Mouse Follicular Center Cell", "d": []}, {"i": "NCIT:C22578", "l": "Mouse Follicular Center Cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5171671", "l": "Lymphocytes | XXX | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002107", "l": "IgD-negative CD38-positive IgG memory B cell", "d": ["An IgD-negative CD38-positive IgG memory B cell is a CD38-positive IgG-positive that has class switched and lacks expression of IgD on the cell surface with the phenotype IgD-negative, CD38-positive, and IgG-positive."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0598102", "l": "polarized cell", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0011018", "l": "lymphoid tissue–inducer cell", "d": ["A group 3 innate lymphoid cell that express ROR gamma t and IL-7R alpha in the absence of lineage markers (e.g. CD3, CD19, B220, CD11c, Gr-1), with the functional ability to interact with mesenchymal cells through lymphotoxin and tumor necrosis factor. Lymphoid tissue-inducer cells are key to the development of lymph nodes and Peyer’s patches."]}]}
{"type": "biolink:Cell", "ic": "81.648881485605159", "identifiers": [{"i": "CL:0002434", "l": "CD24-positive, CD8 single-positive thymocyte", "d": ["A CD8-positive, CD4-negative thymocyte that is CD24-positive and expresses high levels of the alpha-beta T cell receptor."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1182693", "l": "Dark cell of eccrine sweat gland", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2924332", "l": "Erythrocytes.pitted", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:4033048", "l": "respiratory suprabasal cell", "d": ["A respiratory epithelial cell with topographic nuclear position in between the basal and luminal cell of the airway epithelium. This non-basal, intermediate cell has limited proliferative capacity, ultrastructural features of basal cells and no defined features of the typically differentiated cellular phenotypes."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0682642", "l": "fixed or free macrophage", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:1001210", "l": "outer medulla vasa recta ascending limb cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5155287", "l": "Blasts/100 cells | Bone marrow | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "ic": "88.140761698499901", "identifiers": [{"i": "CL:0002381", "l": "uninucleate conidium", "d": ["A conidium that has only one nucleus."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C4528183", "l": "Derived Dental Pulp", "d": []}, {"i": "NCIT:C138973", "l": "Derived Dental Pulp", "d": ["Dental pulp from a tooth."]}]}
{"type": "biolink:Cell", "ic": "61.342154213198413", "identifiers": [{"i": "UMLS:C4527316", "l": "Chimeric Antigen Receptor T-cells", "d": []}, {"i": "NCIT:C137999", "l": "Chimeric Antigen Receptor T-cells", "d": ["Autologous or allogeneic T-lymphocytes that are engineered to contain a chimeric antigen receptor (CAR) that specifically targets a particular antigen."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157373", "l": "CD2 cells | XXX | Cell markers", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5401590", "l": "IL15-NK Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "UMLS:C2350175", "l": "Erythroid Progenitor Cells", "d": []}, {"i": "NCIT:C12526", "l": "Erythroid Stem Cell", "d": ["A unipotent hematopoietic progenitor cell derived from myeloid stem cells that is committed to the erythrocyte cell lineage."]}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "UMLS:C1517678", "l": "Koilocytotic Squamous Cell", "d": []}, {"i": "NCIT:C36808", "l": "Koilocytotic Squamous Cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1113687", "l": "human embryonic stem cell line", "d": []}]}
{"type": "biolink:Cell", "ic": "81.648881485605159", "identifiers": [{"i": "UMLS:C1518176", "l": "Malignant Epithelial Giant Cell", "d": []}, {"i": "NCIT:C36824", "l": "Malignant Epithelial Giant Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "81.247621244257502", "identifiers": [{"i": "CL:0005018", "l": "ghrelin secreting cell", "d": ["A cell that secretes ghrelin, the peptide hormone that stimulates hunger."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C3656574", "l": "Cells.CD3-CD16+CD56+HLA-DR+", "d": []}]}
{"type": "biolink:Cell", "ic": "72.577556932535018", "identifiers": [{"i": "UMLS:C1514146", "l": "Plasmablastic Immunoblast", "d": []}, {"i": "NCIT:C37011", "l": "Plasmablastic Immunoblast", "d": []}]}
{"type": "biolink:Cell", "ic": "90.82444074280258", "identifiers": [{"i": "CL:0002525", "l": "metanephric podocyte", "d": ["A specialized epithelial cell that contains \"feet\" that interdigitate with the \"feet\" of other glomerular epithelial cells in the metanephros."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2339159", "l": "Nonkeratinized cell of epithelium of anal column", "d": []}]}
{"type": "biolink:Cell", "ic": "59.333067381448153", "identifiers": [{"i": "UMLS:C4727509", "l": "Genetically-engineered Immune Cell", "d": []}, {"i": "NCIT:C154231", "l": "Genetically-engineered Immune Cell", "d": ["Any autologous or allogeneic immune cell that has been genetically modified."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C0229589", "l": "Structure of parathyroid oxyphil cell", "d": []}, {"i": "NCIT:C33269", "l": "Parathyroid Gland Oxyphil Cell", "d": ["A cell of the parathyroid gland that has condensed chromatin in a small round nucleus. Its cytoplasm is composed of tightly packed mitochondria and glycogen granules, with rare secretory granules, stains pink, and the margin is usually observed."]}, {"i": "SNOMEDCT:12701006", "d": []}]}
{"type": "biolink:Cell", "ic": "85.457082654197222", "identifiers": [{"i": "CL:0000821", "l": "B-1b B cell", "d": ["A B-1 B cell that has the phenotype CD5-negative, but having other phenotypic attributes of a B-1 B cell."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0004244", "l": "WF4 amacrine cell", "d": ["An amacrine cell with a wide dendritic field, dendrites in S4, and post-synaptic terminals in S4."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5177468", "l": "Plasma cells/100 leukocytes | Blood | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2709134", "l": "Frozen erythrocytes newborn units", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157551", "l": "CD4+CD45RO+ cells | Body fluid | Cell markers", "d": []}]}
{"type": "biolink:Cell", "ic": "73.721563224321088", "identifiers": [{"i": "UMLS:C1515428", "l": "Thymic B-Lymphocyte", "d": []}, {"i": "NCIT:C38329", "l": "Thymic B-Lymphocyte", "d": ["A white blood cell derived from bone marrow precursors which lack any T cell markers. It can give rise to either thymic cortical and medullary progeny, or medullary progeny alone."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5170936", "l": "Leukocytes | Prostatic fluid | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0007019", "l": "epidermal mucus secreting cell", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:4030011", "l": "epithelial cell of proximal tubule segment 3", "d": ["Epithelial cell that is part of segment 3 (S3) of the proximal tubule epithelium."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:4033015", "l": "retinal astrocyte", "d": ["A star-shaped glial cell that is part of some retina. This cell links neurons to blood vessels and may provide structural and physiological support to optic nerve head axons."]}]}
{"type": "biolink:Cell", "ic": "92.728541327098611", "identifiers": [{"i": "CL:0002508", "l": "langerin-negative, CD103-negative lymph node dendritic cell", "d": ["A dermal dendritic cell isolated from skin draining lymph nodes that is langerin-negative, MHC-II-positive, and CD4-negative and CD8a-negative."]}]}
{"type": "biolink:Cell", "ic": "75.58416670140862", "identifiers": [{"i": "UMLS:C1708883", "l": "Malignant Hyperchromatic Epithelial Cell", "d": []}, {"i": "NCIT:C54245", "l": "Malignant Hyperchromatic Epithelial Cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4296892", "l": "Enterochromaffin cell (EC), serotonin-producing", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1518115", "l": "MB03", "d": []}, {"i": "NCIT:C20277", "l": "MB03", "d": ["Provider: Maria Biotech Co. Ltd. - Maria Infertility Hospital Medical Institute, Seoul, Korea. Information from provider and not independently verified by NIH: Cells are positive for cell markers SSEA-3, SSEA-4, Oct-4, alkaline phosphatase activity and telomerase activity; Cells are negative for the cell marker SSEA-1; Cell has normal karyotype (46 XX); Differentiation in vitro into neuron; Cells were cultured in feeder-free culture condition using Matrigel coated plate. This cell line meets the criteria for the use of human embryonic stem cells by federally funded researchers."]}]}
{"type": "biolink:Cell", "ic": "61.883171450034865", "identifiers": [{"i": "UMLS:C1516839", "l": "Endocrine-Stromal Cell", "d": []}, {"i": "NCIT:C41608", "l": "Endocrine-Stromal Cell", "d": ["A cell that forms the supporting matrix of one of the glands that secretes substances into the blood or lymph."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2338585", "l": "Set of cholinergic cells of basal nucleus [Ch4]", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1268005", "l": "Hematopoietic precursor cell", "d": []}, {"i": "SNOMEDCT:127911004", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2334698", "l": "Transitional myocyte of internodal tract", "d": []}]}
{"type": "biolink:Cell", "ic": "84.75972595860604", "identifiers": [{"i": "UMLS:C1510780", "l": "Adenocarcinoma Cell with Eosinophilic Granular Cytoplasm", "d": []}, {"i": "NCIT:C36880", "l": "Adenocarcinoma Cell with Eosinophilic Granular Cytoplasm", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5551176", "l": "Tumor cells", "d": []}, {"i": "SNOMEDCT:252987004", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5219005", "l": "Epithelial cells|NCnc|Urine", "d": []}]}
{"type": "biolink:Cell", "ic": "83.552982069901191", "identifiers": [{"i": "CL:0000975", "l": "short lived plasma cell", "d": ["A fully differentiated plasma cell that lives for months."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002271", "l": "type EC1 enteroendocrine cell", "d": ["A type EC enteredocrine cell in the intestines that stores and secretes substance P and 5-hydroxytryptamine."]}]}
{"type": "biolink:Cell", "ic": "92.728541327098611", "identifiers": [{"i": "UMLS:C1519742", "l": "UCSF ES Cell Line", "d": []}, {"i": "NCIT:C20304", "l": "UCSF ES Cell Line", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C4525936", "l": "Neural Stem Cells-expressing CRAd-S-pk7", "d": []}, {"i": "NCIT:C135612", "l": "Neural Stem Cells-expressing CRAd-S-pk7", "d": ["Neural stem cells (NSCs) that are transfected with the gliomatropic oncolytic adenovirus (OV) CRAd-S-pk7, a conditionally replicative oncolytic adenoviral (CRAd) vector that contains the tumor-specific survivin promoter (S) and a fiber protein polylysine modification (pk7), with potential antineoplastic activity. Upon intracerebral administration of NSC loaded with CRAd-S-pk7, the NSCs preferentially migrate towards tumor cells, and the polylysine moiety of the modified fiber protein expressed by the viral vector specifically targets and binds to tumor-specific heparan sulfate proteoglycans. Subsequently, the virus can infect the tumor cells and viral replication is initiated because E1 gene expression is controlled by the tumor-specific promoter for survivin. This results in the specific lysis of the glioma cells. The pk7 fiber modification and the survivin promoter enable tumor-specific infectivity, and transcriptional targeting and preferential replication in glioma cells, while sparing the surrounding normal brain parenchyma. The pK7 is comprised of a heparan sulfate binding domain incorporated into the fiber protein of the adenovirus."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5177451", "l": "Plasma cell precursor | Blood | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1183496", "l": "Neural plate cell", "d": []}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "UMLS:C0037863", "l": "Spermatocytes", "d": []}, {"i": "NCIT:C12605", "l": "Spermatocyte", "d": ["An immature male germ cell that is formed during the spermatocytogenesis phase of spermatogenesis. Spermatocytes are derived from spermatogonia and develop into spermatids."]}, {"i": "MESH:D013090", "l": "Spermatocytes", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:2000044", "l": "brain microvascular endothelial cell", "d": ["Any microvascular endothelial cell that is part of a brain."]}]}
{"type": "biolink:Cell", "ic": "92.728541327098611", "identifiers": [{"i": "CL:0000588", "l": "odontoclast", "d": ["A specialized osteoclast associated with the absorption and removal of cementum."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C4521448", "l": "Derived Peripheral Blood Mononuclear Cell", "d": []}, {"i": "NCIT:C138972", "l": "Derived Peripheral Blood Mononuclear Cell", "d": ["Mononuclear cells collected from peripheral blood."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5706677", "l": "Posoleucel", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1267838", "l": "Lymphocyte negative for CD3 antigen and positive for CD16 antigen", "d": []}, {"i": "SNOMEDCT:117527001", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0369602", "l": "Leukocytes other", "d": []}]}
{"type": "biolink:Cell", "ic": "82.076046914303362", "identifiers": [{"i": "CL:0000173", "l": "pancreatic D cell", "d": ["A D cell located in the pancreas. Peripherally placed within the islets like type A cells; contains somatostatin."]}]}
{"type": "biolink:Cell", "ic": "69.071635092918072", "identifiers": [{"i": "UMLS:C1522529", "l": "Islet Cell", "d": []}, {"i": "NCIT:C32885", "l": "Islet Cell", "d": ["A pancreatic cell that produces and secretes hormones such as insulin and glucagon."]}, {"i": "SNOMEDCT:360555004", "d": []}]}
{"type": "biolink:Cell", "ic": "89.347505587204751", "identifiers": [{"i": "UMLS:C1709180", "l": "Neoplastic Immunoblast-Like T-Lymphocyte", "d": []}, {"i": "NCIT:C45331", "l": "Neoplastic Immunoblast-Like T-Lymphocyte", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2337419", "l": "Splenic macrophage", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1267920", "l": "Lymphocyte positive for CD42 antigen", "d": []}, {"i": "SNOMEDCT:117588009", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C4724856", "l": "Autologous CD19CAR-CD28-CD137/CD27/CD3zeta-iCasp9-expressing T-lymphocytes", "d": []}, {"i": "NCIT:C148156", "l": "Autologous CD19CAR-CD28-CD137/CD27/CD3zeta-iCasp9-expressing T-lymphocytes", "d": ["Autologous T-lymphocytes that have been transduced with a fourth generation-lentiviral vector to express the 4SCAR19 gene composed of a chimeric antigen receptor (CAR) consisting of a single chain variable fragment (scFv) of anti-CD19 coupled to the co-stimulatory molecules CD28, 4-1BB (CD137), and CD27, and to the cytoplasmic portion of the zeta chain of the human T-cell receptor (CD3zeta), and containing the apoptosis-inducible suicide gene human caspase 9 (iCASP9 or iC9), that is linked to a drug binding domain, with potential immunostimulating and antineoplastic activities. The iCASP9 construct consists of the entire coding sequence for the human FK506-drug binding protein (FKBP12) with an F36V mutation (FKBP12-F36V) that is linked to the gene encoding iC9, which is a modified form of the CASP9 gene where the sequences encoding the endogenous caspase activation and recruitment domains have been deleted. Upon transfusion, anti-CD19-CAR-CD28/CD137/CD27/CD3zeta-iCasp9-expressing autologous T-lymphocytes target and bind to CD19-expressing neoplastic B-cells. This results in a cytotoxic T-lymphocyte (CTL) response against CD19-expressing tumor cells, and causes tumor cell lysis. If the administered T-cells cause unacceptable side effects, the chemical homodimerizer AP1903, which binds to the FKBP12-F36V drug-binding domain, can be administered; this induces caspase 9 expression, and results in apoptosis of the administered 4SCAR19 T-cells. CD19, cluster of differentiation 19, is a B-cell-specific cell surface antigen overexpressed in B-cell lineage tumors. Incorporation of the costimulatory signaling domains increases human T-cell function, expansion, and survival."]}]}
{"type": "biolink:Cell", "ic": "70.83295242545627", "identifiers": [{"i": "UMLS:C1518175", "l": "Malignant Epithelial Clear Cell", "d": []}, {"i": "NCIT:C36784", "l": "Malignant Epithelial Clear Cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5177781", "l": "Polymorphonuclear cells | Peritoneal fluid | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0815000", "l": "neuroblastoma cell", "d": []}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "CL:0000997", "l": "immature CD8_alpha-negative CD11b-positive dendritic cell", "d": ["Immature CD8_alpha-negative CD11b-positive dendritic cell is a CD8_alpha-negative CD11b-positive dendritic cell that is CD80-low, CD86-low, and MHCII-low."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1512788", "l": "Inner phalangeal cell of cochlea", "d": []}, {"i": "NCIT:C32812", "l": "Inner Supporting Cell", "d": ["A tall, slender cell extending from the basilar membrane to the free surface of the organ of Corti. Each cell surrounds an inner hair cell."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1510985", "l": "Autologous Tumor Cell", "d": []}, {"i": "NCIT:C12940", "l": "Autologous Tumor Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "CL:2000010", "l": "dermis blood vessel endothelial cell", "d": ["Any blood vessel endothelial cell that is part of a dermis."]}]}
{"type": "biolink:Cell", "ic": "79.246894609297499", "identifiers": [{"i": "UMLS:C1517812", "l": "Leukemic Small Lymphocyte with Clumped Chromatin", "d": []}, {"i": "NCIT:C41066", "l": "Leukemic Small Lymphocyte with Clumped Chromatin", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157948", "l": "Cells other than spermatozoa | Semen | Fertility testing", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2340022", "l": "Resting histiocyte", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157428", "l": "CD3+CD16+CD56+ cells | Blood | Cell markers", "d": []}]}
{"type": "biolink:Cell", "ic": "82.076046914303362", "identifiers": [{"i": "CL:0000906", "l": "activated CD8-positive, alpha-beta T cell", "d": ["A CD8-positive, alpha-beta T cell with the phenotype CD69-positive, CD62L-negative, CD127-negative, CD25-positive, and CCR7-negative."]}]}
{"type": "biolink:Cell", "ic": "73.476395680690302", "identifiers": [{"i": "UMLS:C1707913", "l": "Endometrioid Stromal Cell", "d": []}, {"i": "NCIT:C53995", "l": "Endometrioid Stromal Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:1000838", "l": "kidney proximal convoluted tubule epithelial cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157457", "l": "CD3+CD8+ (T8 suppressor) cells | Tissue and Smears | Cell markers", "d": []}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "CL:0017005", "l": "lymphoblast", "d": ["A lymphocyte that has gotten larger after being stimulated by an antigen."]}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "CL:0000724", "l": "heterocyst", "d": ["A differentiated cell that functions as a site of nitrogen fixation under aerobic conditions."]}]}
{"type": "biolink:Cell", "ic": "77.271239091128209", "identifiers": [{"i": "UMLS:C0024880", "l": "mast cell", "d": []}, {"i": "NCIT:C12747", "l": "Mast Cell", "d": ["Mast cells are hematopoietic tissue cells that contain coarse, basophilic, metachromatic granules.  They are believed to contain heparin and histamine and derive from hematopoietic progenitor cells."]}, {"i": "MESH:D008407", "l": "Mast Cells", "d": []}, {"i": "SNOMEDCT:6445007", "d": []}]}
{"type": "biolink:Cell", "ic": "88.140761698499901", "identifiers": [{"i": "CL:1000280", "l": "smooth muscle cell of colon", "d": ["A smooth muscle cell that is part of the colon."]}]}
{"type": "biolink:Cell", "ic": "78.185623981295834", "identifiers": [{"i": "UMLS:C1522076", "l": "Abnormal Monocyte", "d": []}, {"i": "NCIT:C37040", "l": "Abnormal Monocyte", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2332398", "l": "Stromal cell of ovary", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:1001099", "l": "kidney efferent arteriole endothelial cell", "d": []}]}
{"type": "biolink:Cell", "ic": "61.697875049310156", "identifiers": [{"i": "CL:0000098", "l": "sensory epithelial cell", "d": ["A specialized epithelial cell involved in sensory perception. Restricted to special sense organs of the olfactory, gustatory, and vestibulocochlear receptor systems; contain sensory cells surrounded by supportive, non-receptive cells."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1520026", "l": "Visceral Afferent Neuron", "d": []}, {"i": "NCIT:C33877", "l": "Visceral Afferent Neuron", "d": ["A cell that conducts a nerve impulse that originated at a receptor in one of the interior organs of the one of the three cavities of the body and proceeds towards the central nervous system."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1257858", "l": "COS-7 Cells", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1440286", "l": "Cells.CD3+CD7+", "d": []}]}
{"type": "biolink:Cell", "ic": "67.105964139802381", "identifiers": [{"i": "CL:0000312", "l": "keratinocyte", "d": ["An epidermal cell which synthesizes keratin and undergoes a characteristic change as it moves upward from the basal layers of the epidermis to the cornified (horny) layer of the skin. Successive stages of differentiation of the keratinocytes forming the epidermal layers are basal cell, spinous or prickle cell, and the granular cell."]}]}
{"type": "biolink:Cell", "ic": "59.178645878518317", "identifiers": [{"i": "UMLS:C1518241", "l": "Malignant Small Cell", "d": []}, {"i": "NCIT:C36860", "l": "Malignant Small Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0000887", "l": "lymph node subcapsular sinus macrophage", "d": ["A lymph node macrophage found in the subcapsular sinus of lymph nodes that participates in sensing, clearance, and antigen presentation of lymph-borne particulate antigens. This macrophage is capable of activating invaraint NKT cells and is CD169-positive."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5151699", "l": "Acute leukemia markers | XXX | Cell markers", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5708808", "l": "Cloud Vitreous Seed", "d": []}, {"i": "NCIT:C189884", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4322813", "l": "CD44+ T lymphocyte", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1519740", "l": "UC01 Cell Line", "d": []}, {"i": "NCIT:C20305", "l": "UC01", "d": ["Provider: University of California, San Francisco, CA. Information from provider and not independently verified by NIH: Cells differentiate in vitro into all three germ layers; Cells are positive for cell marker Oct-4, SSEA-3, SSEA-4, and alkaline phosphatase; Cells are negative for SSEA-1; Cells will be available only for collaboration once the MTA is completed. This cell line meets the criteria for the use of human embryonic stem cells by federally funded researchers."]}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "CL:0011006", "l": "Lugaro cell", "d": ["An inhibitory GABAergic interneuron found in the cerebellar cortex."]}]}
{"type": "biolink:Cell", "ic": "92.728541327098611", "identifiers": [{"i": "CL:0011102", "l": "parasympathetic neuron", "d": ["Parasympathetic neurons are part of the parasympathetic nervous sysem and the cell bodies lie in the brain and sacral region of the spinal cord. The neurons are mainly cholinergic."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1267875", "l": "Lymphocyte positive for CD16 antigen", "d": []}, {"i": "SNOMEDCT:117554003", "d": []}]}
{"type": "biolink:Cell", "ic": "74.37742281270377", "identifiers": [{"i": "CL:0000898", "l": "naive T cell", "d": ["Mature T cell not yet exposed to antigen with the phenotype CCR7-positive, CD45RA-positive, and CD127-positive. This cell type is also described as being CD25-negative, CD62L-high and CD44-low."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1979646", "l": "Blasts.CD36+CD235a+", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C3826624", "l": "Cancer cells--Motility", "d": []}]}
{"type": "biolink:Cell", "ic": "82.076046914303362", "identifiers": [{"i": "UMLS:C0229630", "l": "Sideroblast", "d": []}, {"i": "NCIT:C36718", "l": "Sideroblast", "d": []}, {"i": "SNOMEDCT:53838007", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5168997", "l": "Immunodeficiency markers | XXX | Cell markers", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0684104", "l": "glomerul(o)", "d": []}]}
{"type": "biolink:Cell", "ic": "89.347505587204751", "identifiers": [{"i": "UMLS:C1514933", "l": "Rhabdoid Cell", "d": []}, {"i": "NCIT:C37149", "l": "Rhabdoid Cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0545587", "l": "Blood large lymphocyte", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1276265", "l": "Bite cell (cell)", "d": []}, {"i": "SNOMEDCT:111013009", "d": []}]}
{"type": "biolink:Cell", "ic": "77.271239091128209", "identifiers": [{"i": "CL:0000584", "l": "enterocyte", "d": ["An epithelial cell that has its apical plasma membrane folded into microvilli to provide ample surface for the absorption of nutrients from the intestinal lumen."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1512902", "l": "Interstitial cell of pineal gland", "d": []}, {"i": "NCIT:C32872", "l": "Interstitial Cell of the Pineal Gland", "d": ["A non-neuronal cell that supports the pineal gland. It resembles an astrocyte and is found around blood vessels and among groups of pinealocytes. The nucleus is small, elongated and darkly stained."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C0225323", "l": "Lipoblast (cell)", "d": []}, {"i": "NCIT:C32990", "l": "Lipoblast", "d": ["A connective tissue cell that develops into a fat cell."]}, {"i": "SNOMEDCT:81186000", "d": []}, {"i": "SNOMEDCT:82851002", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1267949", "l": "Lymphocyte positive for CD57 antigen", "d": []}, {"i": "SNOMEDCT:116855000", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0684127", "l": "stage II megakaryocyte", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1440405", "l": "Cells.t(12;22)(q13;q12.2)(ATF1,EWSR1)", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1516469", "l": "Chicken Cells", "d": []}, {"i": "NCIT:C18695", "l": "Chicken Cells", "d": ["Cells derived from the chicken used as a biological model for research."]}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "CL:0000382", "l": "scolopale cell", "d": ["A cell that is part of a scolopidium and surrounds the dendrite of a scolopidial neuron."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0000131", "l": "gut endothelial cell", "d": []}]}
{"type": "biolink:Cell", "ic": "54.874368555193477", "identifiers": [{"i": "UMLS:C0368761", "l": "Blast Cell", "d": []}, {"i": "NCIT:C12918", "l": "Hematopoietic Blast Cell", "d": ["A precursor cell which gives rise to a fully differentiated cell of hematopoietic lineage."]}, {"i": "SNOMEDCT:312256009", "d": []}]}
{"type": "biolink:Cell", "ic": "92.728541327098611", "identifiers": [{"i": "CL:0000991", "l": "CD11c-negative plasmacytoid dendritic cell", "d": ["CD11c-negative plasmacytoid dendritic cell is a leukocyte is CD11c-negative, CD45RA-positive, CD85g-positive(ILT7), CD123-positive, CD303-positive."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1440339", "l": "Cells.CD62L", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1317558", "l": "Agranular neutrophil", "d": []}, {"i": "SNOMEDCT:726589001", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157625", "l": "CD59 cells | Blood | Cell markers", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C2698278", "l": "Autologous Anti-PSMA Gene-Modified T-Lymphocytes", "d": []}, {"i": "NCIT:C78197", "l": "Autologous Anti-PSMA Gene-Modified T-Lymphocytes", "d": ["Autologous prostate specific membrane antigen (PSMA) gene-modified T lymphocytes with potential antineoplastic activity. Human autologous T-lymphocytes are isolated and transduced ex vivo with a retrovirus encoding a chimeric immune receptor (CIR) consisting of an antibody fragment against PSMA fused with signaling domains of the T cell. Upon reintroduction into the patient, autologous anti-PSMA gene-modified T-cells bind to PSMA-expressing prostate cancer cells, which may result in specific cytotoxic T-lymphocyte (CTL) tumor cell killing."]}]}
{"type": "biolink:Cell", "ic": "77.712653754434029", "identifiers": [{"i": "CL:1000600", "l": "lower urinary tract cell", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5205604", "l": "PRGN-3006", "d": []}, {"i": "NCIT:C160847", "l": "Autologous CAR-mbIL15-Safety Switch T-cells PRGN-3006", "d": ["A preparation of autologous T-lymphocytes that have been genetically modified to co-express three transgenes using the Sleeping Beauty (SB) transposon system, including a chimeric antigen receptor (CAR) targeting an undisclosed tumor-associated antigen (TAA), a membrane-bound IL-15 (mbIL15) and a safety/kill switch, with potential immunostimulating and antineoplastic activities. Upon introduction of the autologous PRGN-3006 T-cells into the patient, these T-cells target, bind to and induce selective toxicity in cells expressing this particular TAA. IL-15 is a pro-survival cytokine that is required for the maintenance of long-lived CD8+ memory T-cells. Use of mbIL15 preserves T stem-cell memory (TSCM) through sustained IL-15 signaling, improves T-cell persistence and potentiates the immune response against tumor cells. The safety switch can promote selective elimination of the CAR-T cells. The SB system permits integration of the CAR, the IL-15 fusion variant and safety switch transgenes into T-cells without the need for viral vectors and accelerates the manufacturing process."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:4023158", "l": "octopus cell of the mammalian cochlear nucleus", "d": ["A neuron in the posterior ventral cochlear nucleus that is distinguished by their long, thick and tentacle-shaped dendrites that typically emanate from one side of the cell body."]}]}
{"type": "biolink:Cell", "ic": "82.532694649739099", "identifiers": [{"i": "UMLS:C1522074", "l": "Skin - Melanocyte (MMHCC)", "d": []}, {"i": "NCIT:C22543", "l": "Mouse Melanocyte", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0545062", "l": "P.B. osteoblast", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C3496267", "l": "B4 serotonin cells", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1440367", "l": "Cells.CD90", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:1000281", "l": "smooth muscle cell of cecum", "d": ["A smooth muscle cell that is part of the cecum."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1522257", "l": "Mesodermal Cell / Mesoblast (MMHCC)", "d": []}, {"i": "NCIT:C22686", "l": "Mouse Mesodermal Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5447544", "l": "Autologous Gene-modified Gamma Delta T-cells", "d": []}, {"i": "NCIT:C176993", "l": "Autologous Gene-modified Gamma Delta T-cells", "d": ["A preparation of genetically modified autologous gamma delta T-lymphocytes transduced with a lentiviral vector to encode a DNA repair enzyme, with potential immunomodulating and antineoplastic activities. Upon administration, the autologous gene-modified gamma delta T-cells secrete interferon-gamma (IFN-g) and exert direct killing of tumor cells. In addition, these cells activate the immune system to exert a cytotoxic T-lymphocyte (CTL) response against tumor cells. Gamma delta T-lymphocytes play a key role in the activation of the immune system and do not require major histocompatibility complex (MHC)-mediated antigen presentation to exert their cytotoxic effect. The transduction of gamma delta T-cells may confer resistance to alkylating chemotherapeutic agents including temozolomide and allow the use of gamma delta T-cells as an adjunct to these agents."]}]}
{"type": "biolink:Cell", "ic": "82.076046914303362", "identifiers": [{"i": "CL:4023007", "l": "L2/3 bipolar vip GABAergic interneuron (Mmus)", "d": ["A vip GABAergic cortical interneuron with bipolar morphology, with a soma found in L2/3. L2/3 bipolar vip cells have extending axons across all layers (with preferences for layers II/III and Va) and a dendritic tree that is vertically more restricted than deeper layer vip cells and extend fewer dendrites into the layers outside their home layer (location of soma). L2/3 bipolar vip cells have great variability in firing patterns, though most are continuous adapting. L2/3 bipolar vip cells are more depolarized in their resting state, had less fast rectification, and had smaller after hyperpolarization than deeper vip cells."]}]}
{"type": "biolink:Cell", "ic": "73.721563224321088", "identifiers": [{"i": "CL:0002253", "l": "epithelial cell of large intestine", "d": ["An epithelial cell of the large intestine."]}]}
{"type": "biolink:Cell", "ic": "72.170119586754993", "identifiers": [{"i": "UMLS:C1519778", "l": "Undifferentiated Carcinoma Cell", "d": []}, {"i": "NCIT:C37085", "l": "Undifferentiated Carcinoma Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "65.592359821609847", "identifiers": [{"i": "UMLS:C1514071", "l": "Malignant Primitive Germ Cell", "d": []}, {"i": "NCIT:C36897", "l": "Malignant Primitive Germ Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "87.120474278337809", "identifiers": [{"i": "UMLS:C1517451", "l": "Glandular cell of stomach", "d": []}, {"i": "NCIT:C32655", "l": "Gastric Glandular Cell", "d": ["A cell found in the gastric mucosa that produces and secretes digestive enzymes and acid."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0000132", "l": "corneal endothelial cell", "d": ["An hexagonal, flattened, mitochondria-rich endothelial cell that forms a monolayer on the posterior surface of the cornea (the corneal endothelium). Corneal endothelial cells are derived from the neural crest and are responsible for keeping the cornea transparent by maintaining the tissue in a semi-dry state through the action of their ionic pumps and tight junction barrier."]}]}
{"type": "biolink:Cell", "ic": "90.82444074280258", "identifiers": [{"i": "CL:1000309", "l": "epicardial adipocyte", "d": ["A fat cell that is part of the epicardial fat."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C3831071", "l": "cMet CAR-mRNA Electroporated Autologous T Lymphocytes", "d": []}, {"i": "NCIT:C106230", "l": "cMet CAR-mRNA Electroporated Autologous T Lymphocytes", "d": ["A preparation of autologous T-lymphocytes that have been electroporated with an mRNA encoding a chimeric antigen receptor (CAR) consisting of an anti-human hepatocyte growth factor receptor (HGFR or cMet) scFv (single chain variable fragment) and the zeta chain of the TCR/CD3 complex (CD3-zeta) coupled to the co-stimulatory molecule 4-1BB (CD137), with potential antineoplastic activities. Upon intratumoral administration, cMet CAR-mRNA electroporated autologous T lymphocytes direct T-cells to cMet-expressing tumor cells, which induces a selective toxicity in cMet-expressing tumor cells and causes tumor cell lysis. The 4-1BB co-stimulatory molecule signaling domain enhances activation and signaling after recognition of cMet. The inclusion of the 4-1BB signaling domain may increase the antitumor activity as compared to the inclusion of the CD3-zeta chain alone. The mRNA CAR is expressed for a limited amount of time, which can prevent serious, unforeseen side effects. cMet, a receptor tyrosine kinase overexpressed or mutated in many tumor cell types, plays a key role in cancer cell growth, survival, angiogenesis, invasion, and metastasis."]}]}
{"type": "biolink:Cell", "ic": "90.82444074280258", "identifiers": [{"i": "UMLS:C1882053", "l": "Neoplastic Ghost Cell", "d": []}, {"i": "NCIT:C62111", "l": "Neoplastic Ghost Cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1721044", "l": "Fetal Stem Cells", "d": []}, {"i": "MESH:D053686", "l": "Fetal Stem Cells", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002288", "l": "type V taste receptor cell", "d": ["A cell type that forms the boundary with the surrounding epithelium."]}]}
{"type": "biolink:Cell", "ic": "68.652206388559449", "identifiers": [{"i": "CL:0000127", "l": "astrocyte", "d": ["A class of large neuroglial (macroglial) cells in the central nervous system - the largest and most numerous neuroglial cells in the brain and spinal cord. Astrocytes (from 'star' cells) are irregularly shaped with many long processes, including those with 'end feet' which form the glial (limiting) membrane and directly and indirectly contribute to the blood-brain barrier. They regulate the extracellular ionic and chemical environment, and 'reactive astrocytes' (along with microglia) respond to injury."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5170937", "l": "Leukocytes | Semen | Fertility testing", "d": []}]}
{"type": "biolink:Cell", "ic": "88.140761698499901", "identifiers": [{"i": "CL:0000486", "l": "garland cell", "d": ["A large binucleate cell that forms a 'garland' around the anterior end of the proventriculus (cardia) at its junction with the esophagus in both adults and larvae flies. Each cell is surrounded by a basement membrane and there are numerous micro-invaginations (lacunae) extending from the surface into the cytoplasm. At the mouth of each lacuna is a doubled filament forming a specialised filtration system (diaphragm). The filtrate is endocytosed from the lacunae."]}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "UMLS:C1317543", "l": "Immature monocytes", "d": []}, {"i": "NCIT:C13120", "l": "Immature Monocyte", "d": ["A cell derived from a myeloid stem cell. It is the representation of one stage of monocyte development."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5421208", "l": "Allogeneic CD8+ Memory T-cells", "d": []}, {"i": "NCIT:C175211", "l": "Allogeneic CD8+ Memory T-cells", "d": ["A preparation of allogeneic CD8+ memory T-cells from the same donor of hematopoietic cell transplantation (HCT), that can potentially be used for immune reconstitution purposes. Upon infusion of the allogeneic CD8+ memory T-cells after HCT, these cells may provide recovery for CD8+ memory T-cells and may prevent infections."]}]}
{"type": "biolink:Cell", "ic": "87.120474278337809", "identifiers": [{"i": "CL:0000155", "l": "peptic cell", "d": ["A cell that is usually basal in position, cuboidal with round nucleus, short microvilli, secretes pepsinogen."]}]}
{"type": "biolink:Cell", "ic": "92.728541327098611", "identifiers": [{"i": "CL:0000981", "l": "double negative memory B cell", "d": ["A memory B cell with the phenotype IgD-negative and CD27-negative."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157330", "l": "CD16+CD57+ | White blood cells | Cell markers", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1522193", "l": "PNS - Schwann Cell (MMHCC)", "d": []}, {"i": "NCIT:C22632", "l": "Mouse Schwann Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "79.541110464886842", "identifiers": [{"i": "CL:0000891", "l": "foam cell", "d": ["A type of cell containing lipids in small vacuoles and typically seen in atherolosclerotic lesions, as well as other conditions."]}]}
{"type": "biolink:Cell", "ic": "75.105493098994543", "identifiers": [{"i": "UMLS:C1513946", "l": "Neoplastic Cutaneous Basal Cell", "d": []}, {"i": "NCIT:C36781", "l": "Neoplastic Cutaneous Basal Cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0805579", "l": "Cerebroventricular lining cells", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:3000001", "l": "Hofbauer cell", "d": ["Oval eosinophilic histiocytes with granules and vacuoles found in placenta, which are of mesenchymal origin, in mesoderm of the chorionic villus, particularly numerous in early pregnancy."]}]}
{"type": "biolink:Cell", "ic": "63.808184427458961", "identifiers": [{"i": "CL:0002518", "l": "kidney epithelial cell", "d": ["An epithelial cell of the kidney."]}]}
{"type": "biolink:Cell", "ic": "75.26123597683771", "identifiers": [{"i": "UMLS:C1510717", "l": "Abnormal Cytotrophoblastic Cell", "d": []}, {"i": "NCIT:C36801", "l": "Abnormal Cytotrophoblastic Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1514392", "l": "Premalignant Cell", "d": []}, {"i": "NCIT:C12976", "l": "Premalignant Cell", "d": ["Cells which show sign/s, that they can become cancerous."]}]}
{"type": "biolink:Cell", "ic": "81.648881485605159", "identifiers": [{"i": "CL:4023051", "l": "vascular leptomeningeal cell", "d": ["A type of mesothelial fibroblast that is derived from the neural crest, is localized on blood vessels, and is a key component of the pia and arachnoid membranes surrounding the brain."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C0521184", "l": "Atypical squamous cells of uncertain significance", "d": []}, {"i": "NCIT:C8434", "l": "Atypical Squamous Cell of Undetermined Significance", "d": []}, {"i": "SNOMEDCT:39035006", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5454558", "l": "CD45 (Lymphs) cells | Lower respiratory specimen | Cell markers", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5554875", "l": "Bulk Cell Specimen", "d": []}, {"i": "NCIT:C178223", "l": "Bulk Cell Specimen", "d": ["A biospecimen consisting of multiple cells as a pool."]}]}
{"type": "biolink:Cell", "ic": "92.728541327098611", "identifiers": [{"i": "CL:0000755", "l": "type 3 cone bipolar cell (sensu Mus)", "d": ["An OFF-bipolar neuron found in the retina and having connections with cone photoreceptors cells and neurons in the outer half of the inner plexiform layer. The dendritic tree is delicate and the dendritic tips appear small when compared with type 1 cells. The axon terminal is stratified and restricted to sublamina 2 of the inner plexiform layer."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157366", "l": "CD2 blasts | Bone marrow | Cell markers", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C0524987", "l": "Chief Cells, Gastric", "d": []}, {"i": "NCIT:C32305", "l": "Chief Cell of the Stomach", "d": ["An epithelial cell of the stomach that secretes digestive enzymes. Chief cells may be found at any level in the fundic glands, but are most common in the deeper region, toward the muscularis mucosae. They are basophilic."]}, {"i": "MESH:D019872", "l": "Chief Cells, Gastric", "d": []}, {"i": "SNOMEDCT:70935009", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0009086", "l": "endothelial cell of respiratory system lymphatic vessel", "d": ["An endothelial cell that is part of a respiratory system lymphatic vessel."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5216284", "l": "Myelocytes|NCnc|Pt|Body fld", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157288", "l": "CD126 blasts | XXX | Cell markers", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0003025", "l": "retinal ganglion cell C3", "d": ["A retinal ganglion cell C inner that has sparse dendritic density, and large dendritic field."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5180574", "l": "Segmented neutrophils | Blood | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1183898", "l": "Epithelial cell of prostatic duct", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1514520", "l": "Prostatic Glandular Cell", "d": []}, {"i": "NCIT:C33409", "l": "Prostatic Glandular Cell", "d": ["A secretory cell that produces and secretes prostatic fluid. Prostatic fluid contains citric acid, the enzyme fibrinolysin that liquefies the semen, acid phosphatase, a number of other enzymes and lipids. The secretion of the prostate is the first fraction of the ejaculate."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2340307", "l": "Pterygopalatine ganglion neuron", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2323448", "l": "Endocrine-paracrine cell of prostatic gland", "d": []}]}
{"type": "biolink:Cell", "ic": "77.712653754434029", "identifiers": [{"i": "CL:1001599", "l": "pancreas exocrine glandular cell", "d": ["Glandular cell of exocrine pancreas epithelium. Example: pancreatic acinar cell, glandular cells in pancreatic canaliculi, glandular cells in pancreatic ducts."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5205547", "l": "Gavocabtagene autoleucel", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2339178", "l": "Epithelial cell of esophageal cardiac gland", "d": []}]}
{"type": "biolink:Cell", "ic": "82.532694649739099", "identifiers": [{"i": "UMLS:C0229657", "l": "Plasmablast (cell)", "d": []}, {"i": "NCIT:C37082", "l": "Plasmablast", "d": ["A population of antibody-secreting cells in the blood that are highly proliferative and may act as precursors for plasma cells."]}, {"i": "SNOMEDCT:2579009", "d": []}]}
{"type": "biolink:Cell", "ic": "90.82444074280258", "identifiers": [{"i": "CL:1001111", "l": "kidney loop of Henle thin descending limb epithelial cell", "d": ["An epithelial cell that is part of some loop of Henle thin descending limb."]}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "CL:0002188", "l": "glomerular endothelial cell", "d": ["An endothelial cell found in the glomerulus of the kidney. This cell is flattened, highly fenestrated, and plays a vital role in the formation of glomerular ultrafiltrate."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C4744852", "l": "Autologous iC9-deltaNGFR-CD19CAR-CD3zeta-4-1BB-expressing T-lymphocytes", "d": []}, {"i": "NCIT:C156479", "l": "Autologous iC9-deltaNGFR-CD19CAR-CD3zeta-4-1BB-expressing T-lymphocytes", "d": ["A preparation of autologous T-lymphocytes that have been transduced with a retroviral vector to express a chimeric antigen receptor (CAR) consisting of an anti-CD19 single chain variable fragment (scFv) fused to a human immunoglobulin G1 (IgG1) hinge and a CD8alpha transmembrane domain, linked to the co-stimulatory molecule 4-1BB (CD137) and the cytoplasmic portion of the zeta chain of the human T-cell receptor (CD3zeta), containing the apoptosis-inducible suicide gene human caspase 9 (iCASP9 or iC9), linked to a drug binding domain, and a truncated low-affinity nerve growth factor receptor (deltaNGFR), with potential immunostimulating and antineoplastic activities. The iC9 construct consists of the sequence of the human FK506-binding protein (FKBP12) with an F36V mutation, connected through a Ser-Gly-Gly-Gly-Ser linker to the gene-encoding human caspase 9, which is deleted of its endogenous caspase activation and recruitment domain. Upon transfusion, the iCasp9-deltaNGFR-CD19CAR-CD3zeta-4-1BB-expressing autologous T-lymphocytes target and bind to CD19-expressing neoplastic B-cells. Prior to administration, deltaNGFR is used to select the CAR19-transduced T-cells for further enrichment by flow cytometry using an anti-NGFR antibody."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5575170", "l": "Autologous CD123CAR-CD28-CD3zeta-EGFRt-expressing T Lymphocytes MB-102", "d": []}, {"i": "NCIT:C165435", "l": "Autologous CD123CAR-CD28-CD3zeta-EGFRt-expressing T Lymphocytes MB-102", "d": ["A preparation of genetically modified autologous T-cells transduced with a replication incompetent, self-inactivating (SIN) lentiviral vector expressing a chimeric antigen receptor (CAR) specific for the tumor-associated antigen (TAA) CD123 (interleukin-3 receptor alpha chain or IL3RA) and linked to the  CD28 co-stimulatory signaling domain fused to CD3 zeta, and a truncated form of the human epidermal growth factor receptor (EGFRt), with potential immunostimulating and antineoplastic activities. Upon intravenous administration, the autologous CD123CAR-CD28-CD3zeta-EGFRt-expressing T lymphocytes MB-102 are directed to and induce selective toxicity in CD123-expressing tumor cells. CD123, a subunit of the heterodimeric interleukin-3-receptor (IL-3R), is normally expressed on committed blood progenitor cells in the bone marrow; its overexpression is associated with increased leukemic cell proliferation and aggressiveness. Devoid of both ligand binding domains and tyrosine kinase activity, EGFRt both facilitates detection of the administered T-cells in vivo and can promote elimination of those cells following a cetuximab-induced antibody-dependent cellular cytotoxicity (ADCC) response."]}]}
{"type": "biolink:Cell", "ic": "90.82444074280258", "identifiers": [{"i": "CL:0002351", "l": "progenitor cell of endocrine pancreas", "d": ["A progenitor cell that is able to differentiate into the pancreas alpha, beta and delta endocrine cells. This cell type expresses neurogenin-3 and Isl-1."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0000978", "l": "IgM short lived plasma cell", "d": ["A short lived plasma cell that secretes IgM."]}]}
{"type": "biolink:Cell", "ic": "92.728541327098611", "identifiers": [{"i": "CL:0000674", "l": "interfollicle cell", "d": ["A follicle cell that is part of the stalk connecting adjacent egg chambers."]}]}
{"type": "biolink:Cell", "ic": "89.347505587204751", "identifiers": [{"i": "UMLS:C1517539", "l": "Giant Adenocarcinoma Cell", "d": []}, {"i": "NCIT:C36857", "l": "Giant Adenocarcinoma Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "67.782924002860781", "identifiers": [{"i": "UMLS:C1513963", "l": "Neoplastic Epithelioid Cell", "d": []}, {"i": "NCIT:C37104", "l": "Neoplastic Epithelioid Cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1183982", "l": "Chromaffin cell of left ovary", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0483188", "l": "CD22+CD19+", "d": []}]}
{"type": "biolink:Cell", "ic": "69.453592996529309", "identifiers": [{"i": "CL:0000559", "l": "promonocyte", "d": ["A precursor in the monocytic series, being a cell intermediate in development between the monoblast and monocyte. This cell is CD11b-positive and has fine azurophil granules."]}]}
{"type": "biolink:Cell", "ic": "89.347505587204751", "identifiers": [{"i": "CL:4023065", "l": "meis2 expressing cortical GABAergic cell", "d": ["A GABAergic cell located in the cerebral cortex that expresses meis2."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C4524461", "l": "Autologous Human Anti-CD19CAR-4-1BB-CD3zeta-EGFRt-expressing CD4+/CD8+ T-lymphocytes", "d": []}, {"i": "NCIT:C133191", "l": "Autologous Human Anti-CD19CAR-4-1BB-CD3zeta-EGFRt-expressing CD4+/CD8+ T-lymphocytes", "d": ["A preparation of a defined ratio of CD4+ and bulk CD8+ autologous T-lymphocytes transduced with a lentiviral vector expressing a chimeric antigen receptor (CAR) containing a human anti-CD19 single chain variable fragment (scFv) fused to the signaling domain of 4-1BB (CD137), the zeta chain of the TCR/CD3 complex (CD3-zeta), and a truncated form of the human epidermal growth factor receptor (EGFRt), with potential immunostimulating and antineoplastic activities. Upon intravenous administration, autologous human anti-CD19CAR-4-1BB-CD3zeta-EGFRt-expressing CD4+/CD8+ T-lymphocytes are directed to and induce selective toxicity in CD19-expressing tumor cells. CD19 antigen is a B-cell specific cell surface antigen expressed in all B-cell lineage malignancies. Devoid of both ligand binding domains and tyrosine kinase activity, the expressed EGFRt both facilitates in vivo detection of the administered, transduced T-cells and can promote elimination of those cells through a cetuximab-induced antibody dependent cellular cytotoxicity (ADCC) response. The 4-1BB costimulatory signaling domain enhances both proliferation of T-cells and antitumor activity."]}]}
{"type": "biolink:Cell", "ic": "79.849015605436421", "identifiers": [{"i": "CL:0000171", "l": "pancreatic A cell", "d": ["A type of enteocrine cell found in the periphery of the islets of Langerhans that secretes glucagon."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:4023170", "l": "trigeminal sensory neuron", "d": ["A trigeminal neuron that is responsible for sensation in the face."]}]}
{"type": "biolink:Cell", "ic": "88.140761698499901", "identifiers": [{"i": "CL:0000517", "l": "macrophage derived foam cell", "d": ["A type of foam cell derived from a macrophage containing lipids in small vacuoles and typically seen in atherolosclerotic lesions, as well as other conditions."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5163448", "l": "Eosinophils | Urine sediment | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C4727558", "l": "Autologous TAAs-loaded Autologous Dendritic Cells AV-GBM-1", "d": []}, {"i": "NCIT:C154285", "l": "Autologous TAAs-loaded Autologous Dendritic Cells AV-GBM-1", "d": ["A preparation of autologous dendritic cells (DCs) loaded with immunogenic tumor-associated antigens (TAAs) derived from cultured autologous glioblastoma multiforme (GBM) tumor cells, with potential immunostimulatory and antineoplastic activities. Upon administration, the autologous TAA-loaded DCs AV-GBM-1 expose the immune system to the GBM neoantigens, which results in a cytotoxic T-lymphocyte (CTL)-mediated immune response against the autologous GBM cells leading to GBM cell lysis."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1267860", "l": "Lymphocyte positive for CD9 antigen", "d": []}, {"i": "SNOMEDCT:117542003", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:1000397", "l": "endothelial cell of venous sinus of red pulp of spleen", "d": ["An endothelial cell that is part of the venous sinus of red pulp of spleen."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5382942", "l": "Interferon-gamma producing HLA-B7 Cytomegalovirus specific CD8 cells | Blood | Cell markers", "d": []}]}
{"type": "biolink:Cell", "ic": "58.333101644179401", "identifiers": [{"i": "UMLS:C1518172", "l": "Malignant Endocrine Cell", "d": []}, {"i": "NCIT:C36929", "l": "Malignant Endocrine Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "83.552982069901191", "identifiers": [{"i": "UMLS:C1513988", "l": "Neoplastic Thyroid Gland Oncocyte", "d": []}, {"i": "NCIT:C37095", "l": "Neoplastic Thyroid Gland Oncocyte", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0684135", "l": "short neurons", "d": []}]}
{"type": "biolink:Cell", "ic": "85.457082654197222", "identifiers": [{"i": "CL:4029002", "l": "germline-derived nurse cell", "d": ["A gamete-nursing cell that derives from a germline cell (del Pino, 2021)."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5216276", "l": "Monocytes|NCnc|Pt|Plr fld", "d": []}]}
{"type": "biolink:Cell", "ic": "76.10017597303252", "identifiers": [{"i": "UMLS:C1518238", "l": "Malignant Perineural Cell", "d": []}, {"i": "NCIT:C41434", "l": "Malignant Perineural Cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4733516", "l": "Cytorex EBV", "d": []}]}
{"type": "biolink:Cell", "ic": "72.900487657105927", "identifiers": [{"i": "CL:0000731", "l": "urothelial cell", "d": ["A cell of a layer of transitional epithelium in the wall of the proximal urethra, bladder, ureter or renal pelvis, external to the lamina propria."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5184820", "l": "Variant lymphocytes | Cerebral spinal fluid | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5669732", "l": "Autologous Anti-HER2 CAR-CD28 T Cells", "d": []}, {"i": "NCIT:C185166", "l": "Autologous Anti-HER2 CAR-CD28 T Cells", "d": ["A preparation of autologous T-lymphocytes that have been genetically modified to express a chimeric antigen receptor (CAR) targeting the tumor-associated antigen (TAA) human epidermal growth factor 2 (HER2; ErbB2; HER-2) and coupled to the costimulatory domain of CD28, with potential immunostimulating and antineoplastic activities. Upon administration, autologous anti-HER2 CAR-CD28 T cells target and bind to HER2-expressing tumor cells, thereby inducing selective toxicity in HER2-expressing tumor cells. HER2 is overexpressed in a variety of cancer cell types and is associated with increased tumor cell proliferation."]}]}
{"type": "biolink:Cell", "ic": "89.347505587204751", "identifiers": [{"i": "UMLS:C1519658", "l": "Trophoblast cell", "d": []}, {"i": "NCIT:C33917", "l": "Trophoblastic Cell", "d": ["A cell from the outside layer of tissue on the blastocyte, a hollow ball of cells formed in the early development of an embryo. It attaches the blastocyte to the endometrium of the uterus and supplies nourishment to the embryo. The chorion and amnion are derived from these cells."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2325022", "l": "Myocyte of posterior internodal tract", "d": []}]}
{"type": "biolink:Cell", "ic": "65.629028984204552", "identifiers": [{"i": "CL:0000827", "l": "pro-T cell", "d": ["A lymphoid progenitor cell of the T cell lineage, with some lineage specific marker expression, but not yet fully committed to the T cell lineage."]}]}
{"type": "biolink:Cell", "ic": "84.75972595860604", "identifiers": [{"i": "UMLS:C1511177", "l": "Neoplastic Piloid Astrocyte", "d": []}, {"i": "NCIT:C37138", "l": "Neoplastic Piloid Astrocyte", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1440337", "l": "CD62 Cells", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157253", "l": "CD11+CD20+ cells | White blood cells | Cell markers", "d": []}]}
{"type": "biolink:Cell", "ic": "53.782059021562439", "identifiers": [{"i": "CL:0000071", "l": "blood vessel endothelial cell", "d": ["An endothelial cell that lines the vasculature."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5557384", "l": "Autologous Anti-CD19/CD20 CAR-T Cells KITE-363", "d": []}, {"i": "NCIT:C181943", "l": "Autologous Anti-CD19/CD20 CAR-T Cells KITE-363", "d": ["A preparation of autologous T-lymphocytes engineered to express a chimeric antigen receptor (CAR) specific for the two tumor-associated antigens (TAAs) cluster of differentiation 19 (CD19) and CD20, with potential immunostimulating and antineoplastic activities. Upon administration, the autologous anti-CD19/CD20 CAR-T cells KITE-363 target and bind to CD19- and CD20-expressing tumor B-cells. This induces selective toxicity in tumor B-cells expressing these TAAs. Both CD19 and CD20 are B-cell-specific cell surface antigens overexpressed in B-cell lineage malignancies. Targeting both CD19 and CD20 may prevent tumor cell antigen escape and relapse."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5667051", "l": "Autologous Anti-CD79a/anti-CD20 CAR T-cells bbT369", "d": []}, {"i": "NCIT:C186367", "l": "Autologous Anti-CD79a/anti-CD20 CAR T-cells bbT369", "d": ["A preparation of genetically modified autologous T-lymphocytes that are transduced with a single lentiviral vector (LVV) to express chimeric antigen receptors (CARs) specific for the two tumor-associated antigens (TAAs) cluster of differentiation 20 (CD20) and the B-cell antigen receptor complex-associated protein alpha chain (CD79a), and transfected with an mRNA encoding the Casitas B-lineage lymphoma proto-oncogene-b (CBLB)-targeting megaTAL enzyme to edit the CBLB gene, with potential immunostimulating and antineoplastic activities. Upon administration, the autologous anti-CD20/CD79a CAR-T cells bbT369 target and bind to CD20- and CD79a-expressing tumor B-cells. This induces selective toxicity in tumor B-cells expressing these TAAs. Both CD20 and CD79a are B-cell-specific cell surface antigens overexpressed in B-cell lineage malignancies. Targeting both CD20 and CD79a may prevent tumor cell antigen escape and relapse, and may increase anti-tumor activity. The removal of CBLB, an E3 ubiquitin ligase and a negative regulator of T-cell function, will increase T-cell expansion and activation."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1184310", "l": "Epithelial cell of trachea", "d": []}]}
{"type": "biolink:Cell", "ic": "92.728541327098611", "identifiers": [{"i": "UMLS:C1879556", "l": "Adenocarcinoma Cell with Foamy Cytoplasm", "d": []}, {"i": "NCIT:C60526", "l": "Adenocarcinoma Cell with Foamy Cytoplasm", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1182610", "l": "Corneal epithelial cell", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1881029", "l": "HSV-TK-Transduced Donor Lymphocytes", "d": []}, {"i": "NCIT:C67047", "l": "HSV-TK-Transduced Donor Lymphocytes", "d": ["A preparation of donor lymphocytes transduced with the suicide gene herpes simplex virus thymidine kinase (HSV-TK) with potential immunomodulating activity. Administration of HSV-TK-transduced lymphocytes after T cell-depleted allogeneic stem cell transplantation allows an early controllable immune reconstitution, which takes advantage of the antitumor effect of donor lymphocytes and helps to mitigate the risk of post-transplant opportunistic infection. To control graft-versus-host disease (GvHD) due to donor lymphocyte infusion, HSV-TK-transduced donor lymphocytes are selectively eliminated by administration of the antiviral agent ganciclovir. Ganciclovir, a prodrug, is readily phosphorylated by the suicide gene HSV-TK within HSV-TK-transduced lymphocytes to its monophosphate form and, subsequently, converted into its active triphosphate form, which specifically kills HSV-TK- transduced donor lymphocytes."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C2355611", "l": "Suppressor effector T lymphocyte", "d": []}, {"i": "NCIT:C12544", "l": "Suppressor-Effector T-Lymphocyte", "d": ["T-lymphocytes that respond to signals from suppressor-inducer T-cells by inhibiting either cell-mediated immunity or antibody production by B-cells."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C3640938", "l": "Allodepleted Haploidentical T Cells-expressing Inducible Caspase 9", "d": []}, {"i": "NCIT:C102757", "l": "Allodepleted Haploidentical T Cells-expressing Inducible Caspase 9", "d": ["Allodepleted haploidentical T-lymphocytes transduced with the Gal-V pseudotyped retrovirus vector encoding SFG.iCasp9-2A-deltaCD19, with potential immune reconstitution property. SFG.iCasp9-2A-deltaCD19 contains the suicide gene inducible caspase 9 (iCasp9) linked with a 2A-like cleavable peptide to the selectable marker, truncated human CD19 (deltaCD19). iCasp9 consists of a human FK506 drug-binding domain with an F36V mutation (FKBP12-F36V) linked to human caspase 9 using a short linker (SGGGS). Donor T cell therapy may help control transplant-related viral infections following allogeneic hematopoietic stem cell transplantation. However, even the addition of allodepleted donor T cells can lead to graft-versus-host disease (GVHD). In the event that GVHD begins to develop, the chemical homodimerizer AP1903 can be administered, which binds to the FKBP12-F36V domain activating caspase 9. This results in the death of T cells causing GVHD while sparing the virus reactive T-cells."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1182798", "l": "Epithelial cell of distal tubule", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2736936", "l": "Cells.CD56-CD138+", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4322815", "l": "CD45RO+ T lymphocyte", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5181908", "l": "Stomatocytes | Blood | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0003022", "l": "retinal ganglion cell C5", "d": ["A retinal ganglion cell C outer that has medium dendritic density and field size."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5668437", "l": "Allogeneic Anti-CD70-CAR-IL-15-transduced Cord Blood-derived Natural Killer Cells", "d": []}, {"i": "NCIT:C183511", "l": "Allogeneic Anti-CD70-CAR-IL-15-transduced Cord Blood-derived Natural Killer Cells", "d": ["A preparation of allogeneic, umbilical cord blood (CB)-derived natural killer cells (NKs) that have been engineered to express a chimeric antigen receptor (CAR) specific for the tumor-associated antigen (TAA) human cluster of differentiation 70 (CD70) and interleukin-15 (IL-15), with potential immunostimulating and antineoplastic activities. Upon administration, the allogeneic anti-CD70-CAR-IL-15-transduced CB-derived NK cells target, bind to and induce selective cytotoxicity in CD70-expressing tumor cells. CD70, the ligand for the costimulatory receptor CD27, is overexpressed on the surfaces of various cancer cell types. IL-15 is a pro-survival cytokine that promotes persistence of multiple lymphocyte lineages and potentiates the immune response against tumor cells."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0000982", "l": "IgG plasmablast", "d": ["A plasmablast that secretes IgG."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5446452", "l": "Autologous CRISPR-Cas9 Modified/BCL11A Gene-disrupted Human Hematopoietic Stem and Progenitor Cells OTQ923", "d": []}, {"i": "NCIT:C175342", "l": "Autologous CRISPR-Cas9 Modified/BCL11A Gene-disrupted Human Hematopoietic Stem and Progenitor Cells OTQ923", "d": ["A population of autologous cluster of differentiation 34 (CD34)-positive human hematopoietic stem and progenitor cells (hHSPCs) that are ex-vivo gene-edited with the clustered regularly interspaced short palindromic repeats (CRISPR)-Cas9 nuclease complex at the erythroid lineage-specific enhancer of the B-cell lymphoma/leukemia 11A (BCL11A) gene, with potential usage for transplantation in patients with sickle cell disease (SCD) and beta-thalassemia. CD34-positive HSPCs are isolated from human blood upon apheresis and are genetically modified in vitro using CRISPR/Cas9 technology to specifically disrupt the erythroid enhancer of the BCL11A gene. As BCL11A is a suppressor of fetal hemoglobin (HbF; hemoglobin F) expression, disruption of the BCL11A enhancer decreases the expression of BCL11A and stimulates the expression of HbF in erythrocytes that differentiate from CTX001. Upon infusion back into the patient following myeloablative, conditioning chemotherapy, autologous CRISPR-Cas9 modified/BCL11A enhancer-disrupted CD34+ hHSPCs CTX001 can populate the bone marrow and differentiate into a variety of blood cell types including lymphoid cells, myeloid cells and erythroblasts. The increased production of high levels of HbF in red blood cells (RBCs) compensates for the defective or reduced adult hemoglobin (Hb) in patients with SCD and beta-thalassemia. HbF is a form of the oxygen carrying Hb that is naturally present at birth and is then replaced by the adult form of hemoglobin."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0029974", "l": "Ovum", "d": []}, {"i": "MESH:D010063", "l": "Ovum", "d": []}, {"i": "SNOMEDCT:263828003", "d": []}, {"i": "SNOMEDCT:308796009", "d": []}, {"i": "SNOMEDCT:73153001", "d": []}]}
{"type": "biolink:Cell", "ic": "88.140761698499901", "identifiers": [{"i": "UMLS:C1518267", "l": "Mouse Neuroblast", "d": []}, {"i": "NCIT:C22630", "l": "Mouse Neuroblast", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0007021", "l": "alarm substance cell", "d": ["Secretory cell that produces a chemical mixture that triggers antipredator behavior. The substance is released only upon disruption of the epidermis. [Behavior of teleost fishes, second edition, edited by Pitcher, 1992]"]}]}
{"type": "biolink:Cell", "ic": "49.206570514265373", "identifiers": [{"i": "CL:0000542", "l": "lymphocyte", "d": ["A lymphocyte is a leukocyte commonly found in the blood and lymph that has the characteristics of a large nucleus, a neutral staining cytoplasm, and prominent heterochromatin."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0872357", "l": "oval cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4505243", "l": "Suprachiasmatic Nucleus Neurons", "d": []}, {"i": "MESH:D000074523", "l": "Suprachiasmatic Nucleus Neurons", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1267856", "l": "Lymphocyte positive for both CD8 antigen and CD38 antigen", "d": []}, {"i": "SNOMEDCT:116817005", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1441346", "l": "1000 erythrocytes", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5237449", "l": "Anti-CD19-CAR-CD28/CD20-CAR-4-1BB-expressing Autologous T-lymphocytes Hu1928-Hu20BB", "d": []}, {"i": "NCIT:C165774", "l": "Anti-CD19-CAR-CD28/CD20-CAR-4-1BB-expressing Autologous T-lymphocytes Hu1928-Hu20BB", "d": ["A preparation of autologous human T-lymphocytes that have been genetically modified to express the CAR construct Hu1928-Hu20BB that consists of two chimeric antigen receptor (CAR) constructs: one encoding a fully-human anti-CD19 CAR with a co-stimulatory domain of CD28, Hu19-CD828, and one encoding a human anti-CD20 CAR with a co-stimulatory domain of 4-1BB (CD137), Hu20BB, with potential immunostimulating and antineoplastic activities. Upon re-infusion, the anti-CD19-CAR-CD28/CD20-CAR-4-1BB-expressing autologous T-lymphocytes Hu1928-Hu20BB recognize and kill CD19- and/or CD20-expressing tumor B-cells. This results in a cytotoxic T-lymphocyte (CTL) response against CD19- and/or CD20-expressing tumor cells, thereby causing tumor cell lysis. Both the tumor-associated antigens (TAAs) CD19 and CD20 are B-cell-specific cell surface antigens overexpressed in B-cell lineage malignancies."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5204815", "l": "Alpha/beta T-cell/CD19+ B-cell-depleted Unrelated or Partially Matched Donor-derived Allogeneic Peripheral Blood Stem Cells", "d": []}, {"i": "NCIT:C159940", "l": "Alpha/beta T-cell/CD19+ B-cell-depleted Unrelated or Partially Matched Donor-derived Allogeneic Peripheral Blood Stem Cells", "d": ["A preparation of allogeneic peripheral blood stem cells (PBSCs) from an unrelated or partially matched related donor that have been selectively depleted of alpha/beta T-cells and CD19-positive (CD19+) B-cells with potential immune reconstituting activity. The alpha/beta T-cell/CD19+ B-cell-depleted stem cells contain high amounts of natural killer (NK) cells, gamma/delta T-cells, CD34+ stem cells, and dendritic cells (DCs), while devoid of alpha/beta T-cells and CD19-positive B-cells. Depletion of alpha/beta T-cells, which are implicated in the adaptive immune response that mediates graft-versus-host disease (GvHD), may promote rapid and sustained engraftment, immune reconstitution, and may prevent or reduce the development of GvHD. The depletion of CD19+ B-cells may reduce the risk of Epstein-Barr virus (EBV)-driven post-transplant lymphoproliferative disorders. The retained CD3+ gamma/delta T-cells and NK cells may synergistically exert an anti-leukemic and antiviral effector function, which may further promote engraftment and immune reconstitution."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C4727180", "l": "Cytokine-treated Veto Cells", "d": []}, {"i": "NCIT:C153337", "l": "Cytokine-treated Veto Cells", "d": ["A preparation of activated veto cells, with potential immunostimulating and antineoplastic activities. White blood cells (WBCs), taken from either the patient or a healthy third-party donor, are processed and ex-vivo treated with an as of yet not disclosed mix of cytokines to activate specific cytotoxic veto cells. Upon administration, the veto cells specifically target and bind to tumor or foreign cells, thereby inducing apoptosis. Veto cells are able to selectively activate the immune system to only attack and kill tumor or foreign cells upon transplantation to prevent graft-versus-host disease (GvHD)."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:2000014", "l": "fibroblast of upper leg skin", "d": ["Any skin fibroblast that is part of a upper leg skin."]}]}
{"type": "biolink:Cell", "ic": "81.648881485605159", "identifiers": [{"i": "CL:0000599", "l": "conidium", "d": ["An asexual, nonmotile spore formed by higher fungi; conidia are usually made from the side or tip of specialized sporogenous cells and do not form by progressive cleavage of the cytoplasm."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1512166", "l": "Squamous cell of ectocervix", "d": []}, {"i": "NCIT:C33915", "l": "Ectocervical Squamous Cell", "d": ["A flat, scale-like epithelial cell that lines the vaginal portion of cervix."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:2000063", "l": "ovarian fibroblast", "d": ["Any fibroblast that is part of a female gonad."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5163708", "l": "Erythrocytes | Blood | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "ic": "43.876223334320045", "identifiers": [{"i": "UMLS:C1514104", "l": "Neoplastic Stromal Cell", "d": []}, {"i": "NCIT:C37150", "l": "Neoplastic Stromal Cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5173494", "l": "Mononuclear cells | Bone marrow | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "ic": "65.968527344256771", "identifiers": [{"i": "CL:0000911", "l": "effector T cell", "d": ["A differentiated T cell with ability to traffic to peripheral tissues and is capable of mounting a specific immune response."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5163715", "l": "Erythrocytes | Dialysis fluid peritoneal | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C0369715", "l": "Myelocytes", "d": []}, {"i": "NCIT:C13115", "l": "Myelocyte", "d": ["A cell derived from a promyelocyte. It differentiates into a metamyelocyte. It has a diameter of 10-18 micrometer, and an oval or round nucleus with finely granulated chromatin."]}, {"i": "SNOMEDCT:127915008", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C3495988", "l": "A2 noradrenaline cells", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:4023107", "l": "reticulospinal neuron", "d": ["A neuron with soma location in the reticular formation with axons that extend into the spinal cord such. Reticulospinal neuron activity can lead to a variety of motor behaviors."]}]}
{"type": "biolink:Cell", "ic": "80.511444690059548", "identifiers": [{"i": "UMLS:C1517544", "l": "Giant Epithelial Cell", "d": []}, {"i": "NCIT:C36788", "l": "Giant Epithelial Cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1280543", "l": "Entire syncytial trophoblast", "d": []}, {"i": "SNOMEDCT:256965005", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5555023", "l": "Allogeneic CD20 CAR-grafted Gamma Delta T-cells ADI-001", "d": []}, {"i": "NCIT:C178424", "l": "Allogeneic CD20 CAR-grafted Gamma Delta T-cells ADI-001", "d": ["A preparation of a subset of allogeneic T-lymphocytes that express only gamma chain and delta chain T-cell receptors (TCRs) and that are engineered to express a chimeric antigen receptor (CAR) targeting the tumor-associated antigen (TAA) CD20 (cluster of differentiation 20), with potential immunomodulating and antineoplastic activities. Upon administration, allogeneic CD20 CAR-grafted gamma delta T-cells ADI-001 specifically target and bind to tumor cells expressing CD20. This induces secretion of pro-inflammatory cytokines and results in the lysis of CD20-expressing tumor cells. Gamma delta T-lymphocytes play a key role in the activation of the immune system and do not require major histocompatibility complex (MHC)-mediated antigen presentation to exert their cytotoxic effect. The CD20 antigen, a non-glycosylated cell surface phosphoprotein, is a B-cell specific cell surface antigen overexpressed in B-cell lineage malignancies."]}]}
{"type": "biolink:Cell", "ic": "65.929933841797123", "identifiers": [{"i": "CL:4023064", "l": "caudal ganglionic eminence derived interneuron", "d": ["An interneuron that is derived from the caudal ganglionic eminence."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5186846", "l": "Neutrophils | Fetus | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "ic": "88.140761698499901", "identifiers": [{"i": "UMLS:C1510955", "l": "Malignant Glomus Cell", "d": []}, {"i": "NCIT:C36966", "l": "Malignant Glomus Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "74.240948556675605", "identifiers": [{"i": "CL:1001611", "l": "cerebellar neuron", "d": ["Neuron of the cerebellum."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4510909", "l": "Blast cell positive for CD34 antigen", "d": []}, {"i": "SNOMEDCT:725170002", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1268009", "l": "Basophilic granulocytic cell", "d": []}, {"i": "SNOMEDCT:127917000", "d": []}]}
{"type": "biolink:Cell", "ic": "92.728541327098611", "identifiers": [{"i": "UMLS:C1519513", "l": "Pituitary TSH-Secreting Cells", "d": []}, {"i": "NCIT:C33786", "l": "Thyrotroph Cell", "d": []}, {"i": "MESH:D052684", "l": "Thyrotrophs", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4322822", "l": "CD16+ T lymphocyte", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2328179", "l": "Enteric ganglion neuron", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5173435", "l": "Monocytes | Pericardial fluid | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2323619", "l": "Set of astrocytes", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1515626", "l": "gp100-Reactive Autologous Peripheral Blood Lymphocyte", "d": []}, {"i": "NCIT:C38124", "l": "gp100-Reactive Autologous Peripheral Blood Lymphocyte", "d": ["Human peripheral blood lymphocytes (PBL) isolated from a patient, exposed to the tumor-associated antigen gp100 in vitro, and then transferred back to the same patient to target tumor sites expressing gp100. gp100 human antigen is a wild-type self-antigen expressed by melanocytes, pigmented retinal cells and most melanomas. (NCI04)"]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4245840", "l": "Set of regular cardiac myocytes", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0814996", "l": "Stomach cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4246710", "l": "Vascular smooth muscle cell of coronary artery", "d": []}]}
{"type": "biolink:Cell", "ic": "89.347505587204751", "identifiers": [{"i": "CL:0002346", "l": "Dx5-negative, NK1.1-positive immature natural killer cell, mouse", "d": ["An immature natural killer cell that is NK1.1-positive and DX-5 negative."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1440351", "l": "Cells.CD72", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5154539", "l": "B-cell CD27 and IgD subsets | Blood | Cell markers", "d": []}]}
{"type": "biolink:Cell", "ic": "87.120474278337809", "identifiers": [{"i": "CL:4023044", "l": "non-medulla, extratelencephalic-projecting glutamatergic neuron of the primary motor cortex", "d": ["An extratelencephalic-projecting glutamatergic neuron located in layer 5b of the primary motor cortex that does not project to the medulla. Non-MY ET cells are large, big-tufted cells with the apical dendrite often bifurcating close to the soma, suggesting they are corticospinal cells. Non-MY ET cells have bigger hyperpolarization sag, lower input resistance, and smaller AP width, compared to L5 IT neurons."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C3828361", "l": "Recent Thymic Emigrant", "d": []}, {"i": "NCIT:C112039", "l": "Recent Thymic Emigrant", "d": ["A T-lymphocyte that has completed intrathymic development and has exited the thymus. These cells are the youngest peripheral T-lymphocytes and migrate to secondary lymphoid organs where they slowly mature to become naive T-cells."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1317634", "l": "Agranular platelet", "d": []}, {"i": "SNOMEDCT:726588009", "d": []}]}
{"type": "biolink:Cell", "ic": "81.648881485605159", "identifiers": [{"i": "CL:1000891", "l": "kidney arterial blood vessel cell", "d": []}]}
{"type": "biolink:Cell", "ic": "57.572546547065997", "identifiers": [{"i": "UMLS:C1513978", "l": "Neoplastic Glial Cell", "d": []}, {"i": "NCIT:C37126", "l": "Neoplastic Glial Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:2000047", "l": "brainstem motor neuron", "d": ["Any motor neuron that is part of a brainstem."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1440362", "l": "Cells.CD85", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0005023", "l": "branchiomotor neuron", "d": ["Cranial motor neuron which innervates muscles derived from the branchial (pharyngeal) arches."]}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "UMLS:C1711280", "l": "Neoplastic Somatotroph Cell with Scarce Secretory Granules", "d": []}, {"i": "NCIT:C45940", "l": "Neoplastic Somatotroph Cell with Scarce Secretory Granules", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C3870602", "l": "B cells+monocytes", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5216291", "l": "Neutrophils|NCnc|Pt|Body fld", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5187172", "l": "Fibroblasts^Control", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4511593", "l": "Population of all immature reticulocytes in portion of fluid", "d": []}, {"i": "SNOMEDCT:725998003", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "MESH:D052939", "l": "Schizonts", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C3282339", "l": "Cells, Cultured, Allogeneic", "d": []}]}
{"type": "biolink:Cell", "ic": "92.728541327098611", "identifiers": [{"i": "CL:0000769", "l": "basophilic metamyelocyte", "d": ["A basophil precursor in the granulocytic series, being a cell intermediate in development between a basophilic myelocyte and a band form basophil. The nucleus becomes indented where the indentation is smaller than half the distance to the farthest nuclear margin; chromatin becomes coarse and clumped; specific granules predominate while primary granules are rare. Markers are CD11b-positive, CD15-positive, CD16-positive, CD24-positive, CD33-positive, and CD13-positive."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2336187", "l": "Smooth muscle fiber of prostate", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0009022", "l": "stromal cell of lamina propria of small intestine", "d": ["A stromal cell found in the lamina propria of the small intestine."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0815002", "l": "GABAergic Neurons", "d": []}, {"i": "MESH:D059330", "l": "GABAergic Neurons", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5172547", "l": "Metamyelocytes | Body fluid | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C3891660", "l": "Tumor-Associated Macrophage", "d": []}, {"i": "NCIT:C116387", "l": "Tumor-Associated Macrophage", "d": ["Non-neoplastic macrophages that are found in close proximity to or within a tumor mass."]}, {"i": "MESH:D000084582", "l": "Tumor-Associated Macrophages", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002483", "l": "hair follicle melanocyte", "d": ["A melanocyte that produces pigment within the hair follicle."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C4725769", "l": "Cord Blood-derived Expanded Allogeneic Natural Killer Cells", "d": []}, {"i": "NCIT:C150483", "l": "Cord Blood-derived Expanded Allogeneic Natural Killer Cells", "d": ["A preparation of human umbilical cord blood (UCB)-derived and ex vivo-expanded allogeneic natural killer (NK) cells, with immunomodulating and cytotoxic activities. Upon infusion of the cord blood-derived expanded allogeneic NK cells, these cells recognize and bind to tumor cells, and secrete perforins, granzymes, and cytokines, which cause cancer cell lysis."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0017011", "l": "hillock cell of prostatic urethral epithelium", "d": ["A hillock cell that is part of the prostatic urethra."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002135", "l": "nonkeratinized cell of epidermis", "d": ["Epidermal cells that do not contain keratin. Cell type is usually associated with moist epidermal tissues."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5216305", "l": "Plasma cell precursor|NCnc|Pt|Bld", "d": []}]}
{"type": "biolink:Cell", "ic": "76.659841615658792", "identifiers": [{"i": "CL:0002178", "l": "epithelial cell of stomach", "d": ["An epithelial cell found in the lining of the stomach."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5216273", "l": "Monocytes|NCnc|Pt|Body fld", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1440299", "l": "Cells.CD35", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0086031", "l": "Colony-Forming Units, Hematopoietic", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4740731", "l": "Erythroblasts mid", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5171961", "l": "Malignant cells | Cerebral spinal fluid | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1440147", "l": "Blasts.CD34", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1545462", "l": "CD19+ CD103+ cells", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0022686", "l": "Killer Cells", "d": []}]}
{"type": "biolink:Cell", "ic": "92.728541327098611", "identifiers": [{"i": "CL:0000342", "l": "pigment cell (sensu Vertebrata)", "d": ["Any animal cell containing pigment granules."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2332462", "l": "Basket cell of cerebral cortex", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2323361", "l": "Midget cone bipolar cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2826134", "l": "human myeloid progenitor cells CLT-008", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C4525956", "l": "Autologous Tumor Infiltrating Lymphocytes LN-145", "d": []}, {"i": "NCIT:C135634", "l": "Autologous Tumor Infiltrating Lymphocytes LN-145", "d": ["A proprietary preparation of autologous tumor infiltrating lymphocytes (TILs), with potential immunomodulating activity. The autologous TILs are isolated from an autologous tumor sample and expanded ex vivo in the presence of interleukin-2 (IL-2). Upon infusion of the autologous TILs LN-145 back into the patient, the cells specifically recognize, target and kill the patient's tumor cells."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4740248", "l": "100 cells.CD15", "d": []}]}
{"type": "biolink:Cell", "ic": "63.246254797494437", "identifiers": [{"i": "UMLS:C1513998", "l": "Neoplastic Large Cell with Abundant Cytoplasm", "d": []}, {"i": "NCIT:C37107", "l": "Neoplastic Large Cell with Abundant Cytoplasm", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1257772", "l": "Colony-Forming Units, Erythroid", "d": []}, {"i": "NCIT:C121533", "l": "Erythroid Colony Forming Unit", "d": ["A unit of viable cell concentration defined as the minimum number of hematopoietic stem cells able to produce a detectable colony of erythroid lineage cells that are past the burst forming stage."]}, {"i": "SNOMEDCT:445399000", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5216263", "l": "Malignant cells|NCnc|Pt|Plr fld", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002243", "l": "smooth muscle cell of sphincter of pupil", "d": ["A circular smooth muscle cell of the iris, innervated by the ciliary nerves (parasympathetic), and acting to contract the pupil. This muscle cell derives from neuroectoderm. This smooth muscle cell results from transformation of epithelial cells to smooth muscle cells."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5171661", "l": "Lymphocytes | Fetus | Blood | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1979674", "l": "Cells.CD4+CD7-CD49d-", "d": []}]}
{"type": "biolink:Cell", "ic": "72.072061987060081", "identifiers": [{"i": "CL:0000196", "l": "insect flight muscle cell", "d": ["A muscle cell that is involved in the mechanism of insect flight. This encompasses both, cells that power flight and cells that control flight."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4277737", "l": "Grid Cells", "d": []}, {"i": "MESH:D000071038", "l": "Grid Cells", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C4727549", "l": "Autologous AXL-targeted CAR T-cells CCT301-38", "d": []}, {"i": "NCIT:C154276", "l": "Autologous AXL-targeted CAR T-cells CCT301-38", "d": ["A preparation of genetically modified autologous T-lymphocytes transduced with a lentiviral vector to express a chimeric antigen receptor (CAR) targeting the receptor tyrosine kinase (RTK) AXL, with potential immunomodulatory and antineoplastic activities. After isolation, transduction, and expansion in culture, the CCT301-38 cells are reintroduced into the patient and are activated within the tumor microenvironment (TME) using proprietary Conditionally Active Biologic (CAB) technology. Upon activation, CAB antibodies bind to a proprietary T-cell signaling domain, promoting T-cell recognition and killing of AXL-expressing tumor cells. AXL is a RTK and oncogene that is overexpressed in many cancer types and is involved in the stimulation of tumor cell proliferation."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5177472", "l": "Plasma cells/100 leukocytes | Cerebral spinal fluid | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1171322", "l": "Adult Stem Cells", "d": []}, {"i": "NCIT:C43420", "l": "Adult Stem Cell", "d": ["Mostly multipotent undifferentiated stem cells found in a specific tissue admixed with differentiated cells."]}, {"i": "MESH:D053687", "l": "Adult Stem Cells", "d": []}, {"i": "SNOMEDCT:417904004", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0598625", "l": "myeloma and spleen cell hybrid", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5417906", "l": "Autologous Anti-FLT3 CAR T Cells AMG 553", "d": []}, {"i": "NCIT:C172197", "l": "Autologous Anti-FLT3 CAR T Cells AMG 553", "d": ["A preparation of autologous T-lymphocytes genetically engineered with a chimeric antigen receptor (CAR) specific for the tumor-associated antigen FMS-like tyrosine kinase 3 (FLT3; CD135; STK1; FLK2), with potential immunostimulating and antineoplastic activities. Upon administration, the anti-FLT3 CAR T cells AMG 553 target and bind to tumor cells expressing FLT3, which results in the cytotoxic T-lymphocyte (CTL)-mediated cell killing of FLT3-expressing tumor cells. FLT3, a class III receptor tyrosine kinase (RTK), is overexpressed or mutated in most B-lineage neoplasms and in acute myeloid leukemias (AMLs)."]}]}
{"type": "biolink:Cell", "ic": "85.457082654197222", "identifiers": [{"i": "CL:0000583", "l": "alveolar macrophage", "d": ["A tissue-resident macrophage found in the alveoli of the lungs. Ingests small inhaled particles resulting in degradation and presentation of the antigen to immunocompetent cells. Markers include F4/80-positive, CD11b-/low, CD11c-positive, CD68-positive, sialoadhesin-positive, dectin-1-positive, MR-positive, CX3CR1-negative."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5761785", "l": "TVI-Brain-1", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1522157", "l": "Leukocyte - Promonocyte (MMHCC)", "d": []}, {"i": "NCIT:C22585", "l": "Mouse Promonocyte", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5163720", "l": "Erythrocytes | Pericardial fluid | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1179830", "l": "Epithelial cell of prostate", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2326142", "l": "Keratinized squamous cell", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C3653189", "l": "Alipogene tiparvovec", "d": []}, {"i": "NCIT:C166528", "l": "Alipogene Tiparvovec", "d": []}, {"i": "MESH:C000721108", "l": "Alipogene tiparvovec", "d": []}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "UMLS:C1514001", "l": "Neoplastic Large Cleaved Follicle Center Cell", "d": []}, {"i": "NCIT:C37020", "l": "Neoplastic Large Cleaved Follicle Center Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "88.140761698499901", "identifiers": [{"i": "UMLS:C1881225", "l": "Medium Size Melanoma Cell", "d": []}, {"i": "NCIT:C54163", "l": "Medium Size Melanoma Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "89.347505587204751", "identifiers": [{"i": "CL:0011103", "l": "sympathetic neuron", "d": ["Sympathetic neurons are part of the sympathetic nervous system and are primarily adrenergic producing the neurotransmitter noradrenalin along with other neuropeptides."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0949431", "l": "TC1 Cells", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1510782", "l": "Adenocarcinoma Cell with Perinuclear Clearing", "d": []}, {"i": "NCIT:C36841", "l": "Adenocarcinoma Cell with Perinuclear Clearing", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4266413", "l": "100 cells.CD3", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:4030052", "l": "nucleus accumbens shell and olfactory tubercle D2 medium spiny neuron", "d": ["A DRD2-expressing medium spiny neuron that is part of a nucleus accumbens shell or olfactory tubercle."]}]}
{"type": "biolink:Cell", "ic": "88.140761698499901", "identifiers": [{"i": "CL:1000601", "l": "ureteral cell", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:4030032", "l": "valve interstitial cell", "d": ["An interstitial cell that is part of a cardiac valve leaflet. Along with valve endothelial cells, a valve interstitial cell maintains tissue homeostasis for the function of cardiac valves through secreting biochemical signals, matrix proteins and matrix remodeling enzymes."]}]}
{"type": "biolink:Cell", "ic": "90.82444074280258", "identifiers": [{"i": "CL:0000649", "l": "prickle cell", "d": ["A cell with delicate radiating processes known as desmosomes that form intercellular bridges between other cells of this type. This cell type forms the stratum spinosum (prickle cell layer). A function of this cell is to generate keratin."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0019017", "l": "lymphatic vessel smooth muscle cell", "d": ["A smooth muscle cell that is part of any lymphatic vessel."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0003041", "l": "M9-ON retinal ganglion cell", "d": ["An M9 retinal ganglion cells with synaptic terminals in S2 and is depolarized by illumination of its receptive field center."]}]}
{"type": "biolink:Cell", "ic": "70.595126831462238", "identifiers": [{"i": "UMLS:C1518194", "l": "Malignant Mesothelial Cell", "d": []}, {"i": "NCIT:C36831", "l": "Malignant Mesothelial Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C4527157", "l": "LMP1-specific Chimeric Antigen Receptor-expressing T Lymphocytes", "d": []}, {"i": "NCIT:C136986", "l": "LMP1-specific Chimeric Antigen Receptor-expressing T Lymphocytes", "d": ["A preparation of cytotoxic T-lymphocytes (CTL) transfected with a chimeric antigen receptor (CAR) specifically recognizing the Epstein-Barr virus (EBV) latent membrane protein 1 (LMP1; LMP-1), with potential antineoplastic activity. Upon administration of the LMP1-specific CAR-expressing T lymphocytes to patients with LMP1-positive tumors, the CTLs specifically target and lyse tumor cells expressing LMP1, thereby inhibiting tumor cell proliferation. The tumor-associated antigen (TAA) LMP1 is expressed in various malignancies, including nasopharyngeal cancer and EBV-positive Hodgkin lymphoma."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1267876", "l": "Lymphocyte positive for both CD16 antigen and CD56 antigen", "d": []}, {"i": "SNOMEDCT:117555002", "d": []}]}
{"type": "biolink:Cell", "ic": "72.900487657105927", "identifiers": [{"i": "CL:0000349", "l": "extraembryonic cell", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5706388", "l": "Autologous Anti-CD5 CAR Monocytes MT-101", "d": []}, {"i": "NCIT:C187269", "l": "Autologous Anti-CD5 CAR Monocytes MT-101", "d": ["A preparation of autologous monocytes genetically modified with mRNA technology to express a chimeric antigen receptor (CAR) specific for CD5, with potential immunomodulating and antineoplastic activities. Upon administration, the autologous anti-CD5 CAR monocytes MT-101 specifically recognize and bind to CD5-expressing tumor cells, and expose the immune system to the CD5 glycoprotein. This may elicit a cytotoxic T-lymphocyte (CTL) response against CD5-expressing tumor cells. CD5 is a T-cell surface glycoprotein expressed on the surface of normal T-cells and overexpressed on various B- and T-cell malignancies."]}]}
{"type": "biolink:Cell", "ic": "69.653168928076894", "identifiers": [{"i": "UMLS:C0023516", "l": "Leukocytes", "d": []}, {"i": "NCIT:C12529", "l": "Leukocyte", "d": ["Blood cells that are devoid of hemoglobin, capable of ameboid motion and phagocytosis, and act as the principal components of the immune system."]}, {"i": "MESH:D007962", "l": "Leukocytes", "d": []}, {"i": "SNOMEDCT:52501007", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5666913", "l": "Autologous Anti-FLT3 CAR T Cells TAA05", "d": []}, {"i": "NCIT:C183535", "l": "Autologous Anti-FLT3 CAR T Cells TAA05", "d": ["A preparation of autologous T-lymphocytes genetically engineered with a chimeric antigen receptor (CAR) specific for the tumor-associated antigen FMS-like tyrosine kinase 3 (FLT3; CD135; STK1; FLK2), with potential immunostimulating and antineoplastic activities. Upon administration, the autologous anti-FLT3 CAR T cells TAA05 target and bind to tumor cells expressing FLT3, which results in the cytotoxic T-lymphocyte (CTL)-mediated cell killing of FLT3-expressing tumor cells. FLT3, a class III receptor tyrosine kinase (RTK), is overexpressed or mutated in most B-lineage neoplasms and in acute myeloid leukemias (AMLs)."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0000701", "l": "paraganglia type 2 cell", "d": ["Supports paraganglial type 1 cell."]}]}
{"type": "biolink:Cell", "ic": "72.072061987060081", "identifiers": [{"i": "CL:0002576", "l": "perineurial cell", "d": ["A glial cell that is part of the perineurium. This cell type has thin long bipolar cytoplasmic processes, pinocytotic vesicles, fragments of external lamina and/or external lamina-like material, attachment plaques, and desmosome-like junctions. Perineurial cells historically have been referred to as fibroblasts because of shape; however, unlike fibroblasts, a perineurial cell: does not have a compact nucleus and large endoplasmic reticulum; does have a double basement membrane opposed to a single basal lamina; is carefully joined to other perineurial cells by tight junctions into a single sheet as opposed to arranged in a large mass; and finally, can surround a small axon bundle at a nerve terminal whereas a fibroblast cannot."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1720857", "l": "Adipocytes, Brown", "d": []}, {"i": "MESH:D052437", "l": "Adipocytes, Brown", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5163716", "l": "Erythrocytes | Duodenal fluid | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5401604", "l": "Umbilical Cord Blood Hematopoietic Stem Cells", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0333841", "l": "Hunter-Hurler cell", "d": []}, {"i": "SNOMEDCT:84702007", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1267815", "l": "Lymphocyte positive for both CD2 antigen and CD26 antigen", "d": []}, {"i": "SNOMEDCT:117518002", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5667007", "l": "Allogeneic NK-like Cells GAIA-102", "d": []}, {"i": "NCIT:C185594", "l": "Allogeneic NK-like Cells GAIA-102", "d": ["A preparation of allogeneic, off-the-shelf (OTS), ex-vivo activated and expanded natural killer (NK)-like cells, with a CD3-negative/CD56bright/CD57-negative immature phenotype, with potential cytolytic and antineoplastic activities. Upon infusion, allogeneic NK-like cells GAIA-102 may lyse cancer cells. These cells also secrete pro-inflammatory cytokines, which further stimulate anti-tumor immune responses."]}]}
{"type": "biolink:Cell", "ic": "77.712653754434029", "identifiers": [{"i": "CL:0002187", "l": "basal cell of epidermis", "d": ["A basally situated, mitotically active, columnar-shaped keratinocyte attached to the basement membrane."]}]}
{"type": "biolink:Cell", "ic": "75.26123597683771", "identifiers": [{"i": "UMLS:C1519599", "l": "Transformed Neoplastic Lymphocyte", "d": []}, {"i": "NCIT:C40562", "l": "Transformed Neoplastic Lymphocyte", "d": []}]}
{"type": "biolink:Cell", "ic": "59.164784581475494", "identifiers": [{"i": "UMLS:C1511246", "l": "Bone marrow stem cell", "d": []}, {"i": "NCIT:C13456", "l": "Bone Marrow Stem Cell", "d": ["A hematopoietic stem cell found in the bone marrow."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1513067", "l": "Neoplastic Medium-Sized Lymphocyte with Pale Cytoplasm", "d": []}, {"i": "NCIT:C37007", "l": "Neoplastic Medium-Sized Lymphocyte with Pale Cytoplasm", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5399350", "l": "Tecartus", "d": []}]}
{"type": "biolink:Cell", "ic": "87.120474278337809", "identifiers": [{"i": "CL:0000722", "l": "cystoblast", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157260", "l": "CD117 blasts | Blood | Cell markers", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5446525", "l": "WT1-H/K-HELP-survivin-H/K-HELP-MAGE-A4-H / K-HELP-MUC1-22 Peptide-loaded Autologous Dendritic Cells", "d": []}, {"i": "NCIT:C175443", "l": "WT1-H/K-HELP-survivin-H/K-HELP-MAGE-A4-H / K-HELP-MUC1-22 Peptide-loaded Autologous Dendritic Cells", "d": ["A preparation of autologous dendritic cells (DCs) pulsed with helper/killer-hybrid epitope long peptides (H/K-HELP) of Wilms tumor 1 (WT1 H/K-HELP), survivin, melanoma-associated antigen 4 (MAGE-4) and human mucin 1-22 (Muc1-22), with potential immunomodulating and antineoplastic activities. Upon administration of WT1-H/K-HELP-survivin-H/K-HELP-MAGE-A4-H / K-HELP-Muc1-22 peptide-loaded autologous DCs may stimulate the host immune system to mount an anti-tumoral cytotoxic T lymphocyte (CTL), T-helper (Th), and antibody responses against WT1-, survivin-, MAGE-4- and Muc1-22-expressing cancer cells, resulting in tumor cell lysis. WT1, survivin, MAGE-4 and Muc-1-22, tumor-associated antigens (TAAs), are overexpressed on a variety of cancer cells. The DCs loaded with the long fusion polypeptides, comprising of one or more helper epitopes and killer epitopes, may enhance antigen-specific CTL and Th cell production more efficiently than when the DCs are loaded with a mixture of helper epitope and killer epitope."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0545588", "l": "Blood plasmacytic cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1183357", "l": "Type-1 epithelial cell of thymus", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1135917", "l": "Myoblasts, Cardiac", "d": []}, {"i": "MESH:D032386", "l": "Myoblasts, Cardiac", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0333809", "l": "Microcytic hypochromic erythrocyte", "d": []}, {"i": "SNOMEDCT:62570005", "d": []}]}
{"type": "biolink:Cell", "ic": "90.82444074280258", "identifiers": [{"i": "CL:0002203", "l": "brush cell of epithelium proper of large intestine", "d": ["Brush cell found in the epithelial layer of the colon."]}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "UMLS:C4055074", "l": "Effector Memory Immune Cell", "d": []}, {"i": "NCIT:C122731", "l": "Effector Memory Immune Cell", "d": ["A population of long-lived antigen-specific immune cells, usually T-lymphocytes expressing CD8 and effector cytokines, that are maintained by the immune system. Upon subsequent exposure to their target antigen, these cells rapidly become effector cells."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0000411", "l": "Caenorhabditis hypodermal cell", "d": ["An epithelial cell of the hypodermis of Caenorhabditis."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5184823", "l": "Variant lymphocytes | Pleural fluid | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5219170", "l": "Leukocytes|NCnc|Urine", "d": []}]}
{"type": "biolink:Cell", "ic": "89.347505587204751", "identifiers": [{"i": "CL:0002223", "l": "anterior lens cell", "d": ["A cell of the transparent layer of simple cuboidal epithelium over the anterior surface of the lens; transform into lens fiber(s)."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002388", "l": "multinucleate arthroconidium", "d": ["An arthroconidium that has more than one nucleus."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1717693", "l": "Chronic leukemia markers", "d": []}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "CL:0000872", "l": "splenic marginal zone macrophage", "d": ["A splenic macrophage found in the marginal zone of the spleen, involved in recognition and clearance of particulate material from the splenic circulation. Markers include F4/80-negative, MARCO-positive, SR-A-positive, SIGN-R1-positive, and Dectin2-positive."]}]}
{"type": "biolink:Cell", "ic": "87.120474278337809", "identifiers": [{"i": "CL:0000750", "l": "OFF-bipolar cell", "d": ["A bipolar neuron found in the retina and having connections with photoreceptors cells and neurons in the outer half of the inner plexiform layer. These cells depolarize in response to light to dark transition."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:4023110", "l": "amygdala pyramidal neuron", "d": ["A pyramidal neuron with soma located in the amygdala."]}]}
{"type": "biolink:Cell", "ic": "90.82444074280258", "identifiers": [{"i": "UMLS:C0009013", "l": "Clone Cells", "d": []}, {"i": "NCIT:C16441", "l": "Cell Clone", "d": ["A population of genetically identical cells derived by mitosis from a single progenitor."]}, {"i": "MESH:D002999", "l": "Clone Cells", "d": []}, {"i": "SNOMEDCT:47308002", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4699465", "l": "Monotypic lambda plasma cells", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2323094", "l": "Melanocyte of skin", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2333889", "l": "Cardiocyte - general anatomical term", "d": []}]}
{"type": "biolink:Cell", "ic": "78.96520244130248", "identifiers": [{"i": "CL:0000860", "l": "classical monocyte", "d": ["A monocyte that responds rapidly to microbial stimuli by secreting cytokines and antimicrobial factors and which is characterized by high expression of CCR2 in both rodents and humans, negative for the lineage markers CD3, CD19, and CD20, and of larger size than non-classical monocytes."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1507178", "l": "Cells.CD8+CD95+", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1514658", "l": "RL15", "d": []}, {"i": "NCIT:C20292", "l": "RL15", "d": ["Provider: Reliance Life Sciences, Mumbai, India. No information from provider. This cell line meets the criteria for the use of human embryonic stem cells by federally funded researchers."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0011109", "l": "hypocretin-secreting neuron", "d": ["A neuron that releases hypocretin as a neurotransmitter."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1955256", "l": "Erythrocytes.fetal", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C3831170", "l": "CD138CAR-CD137/TCRzeta-expressing T Lymphocytes", "d": []}, {"i": "NCIT:C107505", "l": "CD138CAR-CD137/TCRzeta-expressing T Lymphocytes", "d": ["T-lymphocytes transduced with a retroviral vector expressing a chimeric antigen receptor (CAR) specific for syndecan-1 (CD138) (CART-138 T cells) coupled to the signaling domain of 4-1BB (CD137), and the zeta chain of the T-cell receptor (TCRzeta), with potential immunomodulating and antineoplastic activities. Upon transfusion, CD138CAR- CD137/TCRzeta -expressing T lymphocytes directs the T-lymphocytes to syndecan-1-expressing tumor cells and induces selective toxicity in those tumor cells. The 4-1BB co-stimulatory molecule signaling domain enhances activation and signaling after recognition of syndecan-1. Syndecan-1, a type 1 transmembrane proteoglycan and tumor associated antigen, is overexpressed in a variety of cancer cells. It plays a key role in the regulation of cell growth, differentiation, and adhesion, and its expression is correlated with poor prognosis."]}]}
{"type": "biolink:Cell", "ic": "92.728541327098611", "identifiers": [{"i": "CL:0002349", "l": "CD27-high, CD11b-low natural killer cell, mouse", "d": ["A natural killer cell that is CD27-high and CD11b-low."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:1000358", "l": "microfold cell of epithelium proper of ileum", "d": ["A M cell that is part of the epithelium proper of ileum."]}]}
{"type": "biolink:Cell", "ic": "75.923665061460838", "identifiers": [{"i": "UMLS:C1512550", "l": "Hyperchromatic Spindle Cell", "d": []}, {"i": "NCIT:C37084", "l": "Hyperchromatic Spindle Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5706397", "l": "Autologous GCC-targeting CAR T Cells GCC19CART", "d": []}, {"i": "NCIT:C187317", "l": "Autologous GCC-targeting CAR T Cells GCC19CART", "d": ["A preparation of autologous T-lymphocytes that are genetically engineered to express a chimeric antigen receptor (CAR) targeting the enterocyte differentiation antigen guanylyl cyclase C (GUCY2C) that are activated with CAR T-cells specific for the CD19 antigen, and coupled to as of yet not fully elucidated signaling domains, with potential immunostimulating and antineoplastic activities. Upon intravenous administration, the autologous GCC-targeting CAR T cells GCC19CART are directed to, specifically bind to, activate, proliferate and release cytokines that promote killing of GCC-expressing tumor cells. GCC is overexpressed in various tumor cell types. The activation of the GCC-targeting T-cells by activated CD19 CAR  that secrete cytokines, enhances CAR T-cell activation and proliferation,  and may increase the T-cell-mediated killing of GCC-expressing tumor cells."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5174623", "l": "Neutrophils | Prostatic fluid | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4317150", "l": "Vacuolated lymphocyte", "d": []}, {"i": "SNOMEDCT:725384001", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5184399", "l": "Unidentified cells | Peritoneal fluid | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1267823", "l": "T lymphocyte positive for both CD4 antigen and CD29 antigen", "d": []}, {"i": "SNOMEDCT:115401003", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1516696", "l": "Collecting Cell", "d": []}, {"i": "NCIT:C32343", "l": "Collecting Cell", "d": ["A simple cuboidal epithelial cell lining the collecting duct of the kidney. Its function is dependent upon its location on the collecting duct."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0882908", "l": "Cell positive for CD61 antigen", "d": []}, {"i": "SNOMEDCT:116829001", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1267908", "l": "Lymphocyte positive for both CD33 antigen and CD44 antigen", "d": []}, {"i": "SNOMEDCT:117579000", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2325885", "l": "Free macrophage", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5216285", "l": "Neutrophils.band form|NCnc|Pt|Bld", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4704952", "l": "Bone Marrow Mesenchymal Stem Cells", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C4055234", "l": "Circulating Clonotypic B-Cell", "d": []}, {"i": "NCIT:C120462", "l": "Circulating Clonotypic B-Cell", "d": ["A B-lymphocyte that is hyperdiploid, has clonotypic IgH gene rearrangements, and is found in the peripheral blood of patients with monoclonal gammopathy of undetermined significance or multiple myeloma."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1370102", "l": "Cells.CD4+CD45RA+/Cells.CD8", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2335115", "l": "Epicardial adipocyte", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5163719", "l": "Erythrocytes | Gastric fluid | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0001020", "l": "mature CD8_alpha-low Langerhans cell", "d": ["Mature CD8_alpha-low Langerhans cell is a CD8_alpha-low Langerhans cell that that is CD80-high, CD86-high, MHCII-high and is CD83-positive."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5174641", "l": "Neutrophils.hypogranulated | Blood | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5179528", "l": "Reticulocytes.low fluorescence/100 erythrocytes | Blood | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5220597", "l": "Leukocyte clumps|Urine/Urine sed", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4253023", "l": "Set of enteroendocrine cells", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5155171", "l": "Blasts | Pleural fluid | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1514077", "l": "Neoplastic Round Cell with Lipomatous Differentiation", "d": []}, {"i": "NCIT:C37102", "l": "Neoplastic Round Cell with Lipomatous Differentiation", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "MESH:D013171", "l": "Spores, Bacterial", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1182787", "l": "Epithelial cell of nephron", "d": []}]}
{"type": "biolink:Cell", "ic": "74.953330836288131", "identifiers": [{"i": "CL:2000004", "l": "pituitary gland cell", "d": ["Any cell that is part of a pituitary gland."]}]}
{"type": "biolink:Cell", "ic": "71.163959742754642", "identifiers": [{"i": "UMLS:C0022567", "l": "keratinocyte", "d": []}, {"i": "NCIT:C12589", "l": "Keratinocyte", "d": ["The keratin-producing cells of the epidermis.  They are the predominant cells of the epidermis that form in the deep basal layer of the stratified epithelium of the epidermis.  They gradually migrate upward to the cornified layer of the epidermis undergoing characteristic changes."]}, {"i": "MESH:D015603", "l": "Keratinocytes", "d": []}, {"i": "SNOMEDCT:74447004", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0312866", "l": "Sensitized leukocyte", "d": []}, {"i": "SNOMEDCT:64668006", "d": []}]}
{"type": "biolink:Cell", "ic": "92.728541327098611", "identifiers": [{"i": "CL:0002084", "l": "Boettcher cell", "d": ["A Boettcher cell is a polyhedral cells on the basilar membrane of the cochlea, and is located beneath Claudius cells. A Boettcher cell is considered a supporting cell for the organ of Corti, and is present only in the lower turn of the cochlea. These cells interweave with each other, and project microvilli into the intercellular space. Because of their structural specialization, a Boettcher cell is believed to play a significant role in the function of the cochlea. They demonstrate high levels of calmodulin, and may be involved in mediating Ca(2+) regulation and ion transport."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0009090", "l": "endothelial colony forming cell", "d": ["An adult endothelial progenitor cell that is resident of adult vasculature and capable of differentiating to regenerate endothelial cell populations. Endothelial colony forming cells are characterised in vivo by clonal proliferative status, de novo vessel formation, homing to ischemic sites and paracrine support of angiogenesis. These cells are phenotypically similar to endothelial cells."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4304630", "l": "Population of all acanthocytes in portion of fluid", "d": []}, {"i": "SNOMEDCT:719690001", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0009076", "l": "neuro-medullary thymic epithelial cell", "d": ["A thymic medullary epithelial cell that expresses neuroendocrine biomarkers."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5173501", "l": "Mononuclear cells atypical | Blood | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1181164", "l": "Set of peripheral neuroglial cells", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0009003", "l": "larval midgut cell", "d": ["Any cell in the midgut (middle subdivision of a digestive tract) of an insect larva."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0009007", "l": "gastrointestinal tract (lamina propria) macrophage of small intestine", "d": ["A macrophage which is resident in the lamina propria of the small intestine."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1514043", "l": "Neoplastic Neural Crest Cell", "d": []}, {"i": "NCIT:C37148", "l": "Neoplastic Neural Crest Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:4033043", "l": "lung interstitial macrophage", "d": ["A macrophage that is part of the lung connective tissue (pulmonary interstitium). This cell performs tissue remodeling and contributes to barrier immunity through antigen presentation."]}]}
{"type": "biolink:Cell", "ic": "89.347505587204751", "identifiers": [{"i": "CL:0009010", "l": "transit amplifying cell", "d": ["Transit-amplifying cells (TACs) are an undifferentiated population in transition between stem cells and differentiated cells."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0333858", "l": "Small non-cleaved cell", "d": []}, {"i": "SNOMEDCT:33872006", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4518148", "l": "Population of all spermatozoa with coiled tail in portion of fluid", "d": []}, {"i": "SNOMEDCT:725254007", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C2346885", "l": "Autologous LMP1-/LMP2- Specific Cytotoxic T-Lymphocytes", "d": []}, {"i": "NCIT:C70836", "l": "Autologous LMP1-/LMP2- Specific Cytotoxic T-Lymphocytes", "d": ["A preparation of cytotoxic T-lymphocytes (CTL), specifically reactive to the Epstein-Barr virus (EBV) latent membrane proteins (LMP) 1 and 2, with potential antineoplastic activity. Autologous dendritic cells and EBV-infected lymphoblastoid cell lines (LCL) from patients with EBV-positive nasopharyngeal carcinoma (NPC) are transduced with an LMP1/LMP2-expressing adenoviral vector, are irradiated, and then are used to stimulate and expand autologous CTL to produce autologous LMP1-/LMP2-specific CTL ex vivo. Administration of autologous LMP1-/LMP2- specific cytotoxic T-lymphocytes may result in a specific CTL response against tumor cells expressing LMP1 and LMP2, resulting in cell lysis and inhibition of tumor cell proliferation in vivo. Among a limited set of viral antigens expressed by NPC cells, LMP1 and LMP2 are weak immunogens which, nevertheless, are capable of inducing a T-lymphocyte response."]}]}
{"type": "biolink:Cell", "ic": "90.82444074280258", "identifiers": [{"i": "CL:0009006", "l": "enteroendocrine cell of small intestine", "d": ["An enteroendocrine cell that is located in the small intestine."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0682641", "l": "phagocytic reticular cell", "d": []}]}
{"type": "biolink:Cell", "ic": "83.023198044254755", "identifiers": [{"i": "UMLS:C1514177", "l": "Pleomorphic Plasma Cell", "d": []}, {"i": "NCIT:C37083", "l": "Pleomorphic Plasma Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002472", "l": "MHC-II-low non-classical monocyte", "d": ["Gr1-low non-classical monocyte that has low to intermediate expression of the MHC-II complex."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1517357", "l": "Geron H14 stem cell line", "d": []}, {"i": "NCIT:C20260", "l": "GE14", "d": ["Provider: Geron Corporation, Menlo Park, CA. No information from provider. This cell line meets the criteria for the use of human embryonic stem cells by federally funded researchers."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0524456", "l": "Structure of endocervical glandular cell", "d": []}, {"i": "SNOMEDCT:91767003", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157609", "l": "CD55 and CD59 RBC | Blood | Cell markers", "d": []}]}
{"type": "biolink:Cell", "ic": "75.26123597683771", "identifiers": [{"i": "UMLS:C1512106", "l": "Dysplastic Megakaryocyte", "d": []}, {"i": "NCIT:C37046", "l": "Dysplastic Megakaryocyte", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1510930", "l": "Anti-MART-1 TCR Retroviral Vector-Transduced Autologous TIL", "d": []}, {"i": "NCIT:C38137", "l": "Anti-MART-1 TCR Retroviral Vector-Transduced Autologous TIL", "d": ["Human tumor infiltrating lymphocytes (TIL) isolated from a melanoma patient and were engineered to react with the melanoma antigen MART-1 (Melanoma Antigen Recognized by T cells, also called Melan-A). These TILs are transfected with a retroviral vector encoding anti-MART-1 specific T-cell receptors, grown in culture, and then transferred back to the patient. These genetically modified TIL may recognize and halt the growth of MART-1-expressing melanoma cells."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5204822", "l": "Autologous HPV16 E7-specific HLA-A*02:01-restricted TCR Gene Engineered Lymphocytes KITE-439", "d": []}, {"i": "NCIT:C159977", "l": "Autologous HPV16 E7-specific HLA-A*02:01-restricted TCR Gene Engineered Lymphocytes KITE-439", "d": ["A preparation of autologous T-lymphocytes that have been genetically modified to express a T-cell receptor (TCR) specific for the human leukocyte antigen (HLA)-A*02:01-restricted human papillomavirus type 16 isoform E7 protein (HPV16 E7) with potential antineoplastic activity. Upon isolation, transduction, expansion ex vivo and re-introduction into the patient, the autologous HPV16 E7-specific HLA-A*02:01-restricted T-lymphocytes KITE-439 target and bind HPV16 E7-expressing tumor cells. This may lead to cytotoxic T-lymphocyte (CTL)-mediated elimination of tumor cells expressing the HPV16 E7 antigen. HPV16 E7, a cell surface glycoprotein and tumor-associated antigen (TAA), is overexpressed in various HPV-mediated cancers."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5216224", "l": "Leukocytes other|NCnc|Pt|Bld", "d": []}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "CL:0011010", "l": "lateral mesodermal cell", "d": ["A cell derived from the mesoderm that is found at the periphery of the embryo."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002154", "l": "early promyelocyte", "d": ["A promyelocyte with a nucleus that is indented and contains more marginated heterochromatin compared to its precursor cell (myeloblast); cytoplasm is deeply basophilic and contains numerous mitochondria and meandering cysternae of endoplasmic reticulum; largest of the granulocyte lineages."]}]}
{"type": "biolink:Cell", "ic": "66.491863471761647", "identifiers": [{"i": "UMLS:C0005773", "l": "Blood Cells", "d": []}, {"i": "NCIT:C12519", "l": "Peripheral Blood Cell", "d": ["A general term describing the three cellular components of blood (white blood cells, red blood cells, and platelets), all which are made in the bone marrow. (Lymphoma Information Network Glossary)"]}, {"i": "MESH:D001773", "l": "Blood Cells", "d": []}, {"i": "SNOMEDCT:63370004", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0000721", "l": "equatorial cone cell (sensu Endopterygota)", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4042879", "l": "Mouse Embryonic Stem Cells", "d": []}, {"i": "MESH:D000066450", "l": "Mouse Embryonic Stem Cells", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C3831522", "l": "Anti-CD19-CAR FMC63-28Z Retroviral Vector-transduced Allogeneic T-lymphocytes", "d": []}, {"i": "NCIT:C111041", "l": "Anti-CD19-CAR FMC63-28Z Retroviral Vector-transduced Allogeneic T-lymphocytes", "d": ["Allogeneic T-lymphocytes derived from peripheral blood mononuclear cells (PBMC) transduced with a retroviral vector expressing a chimeric antigen receptor (CAR) consisting of both the light and heavy chain variable regions of anti-CD19 monoclonal antibody FMC63, coupled to the molecule CD28 and the signaling domain of the zeta chain of the T-cell receptor (TCR) (FMC63-28Z), with potential immunomodulating and antineoplastic activities. Upon transfusion, the anti-CD19-CAR FMC63-28Z retroviral vector-transduced allogeneic T lymphocytes specifically recognize and kill CD19-expressing tumor cells. CD19 antigen is a B-cell specific cell surface antigen, which is expressed in all B-cell lineage malignancies and normal B-cells."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5418869", "l": "Anti-CD19 iCAR NK Cells", "d": []}, {"i": "NCIT:C170903", "l": "Anti-CD19 iCAR NK Cells", "d": ["A preparation of natural killer (NK) cells engineered to express an inhibitory chimeric antigen receptor (iCAR) specific for the tumor-associated antigen (TAA) cluster of differentiation 19 (CD19), with potential immunostimulating and antineoplastic activities. Upon administration, anti-CD19 iCAR-NK cells recognize, bind to and induce selective cytotoxicity in CD19-expressing tumor cells. The iCAR is designed to spare normal cells from NK cell actions by including an inhibitory receptor that is activated upon binding to antigens that are present on normal cells only. CD19 antigen is a B-cell specific cell surface antigen expressed in all B-cell lineage malignancies."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1979673", "l": "Cells.CD4+CD7-CD26-", "d": []}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "CL:1000979", "l": "ureter smooth muscle cell", "d": []}]}
{"type": "biolink:Cell", "ic": "88.140761698499901", "identifiers": [{"i": "CL:1000326", "l": "ileal goblet cell", "d": ["A goblet cell that is part of the epithelium proper of ileum."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157343", "l": "CD19 blasts | Bone marrow | Cell markers", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C3899032", "l": "Genetically Engineered NY-ESO-1-specific T Lymphocytes", "d": []}, {"i": "NCIT:C116846", "l": "Genetically Engineered NY-ESO-1-specific T Lymphocytes", "d": ["A preparation of human T-lymphocytes recognizing the tumor-associated antigen (TAA), cancer/testis antigen 1 (NY-ESO-1), with potential immunostimulating and antineoplastic activities. Genetically engineered NY-ESO-1-specific T-lymphocytes target tumor cells expressing the NY-ESO-1 antigen, resulting in tumor cell lysis. NY-ESO-1, an antigen found in normal testis, is overexpressed on the surface of various tumor cell types."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157336", "l": "CD179a blasts | Blood | Cell markers", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2325383", "l": "Border cell of cochlea", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0008006", "l": "muscle founder cell", "d": ["A myoblast that detemines the properties (size, shape and attachment to the epidermis) of a `somatic muscle myotube` (CL:0008003) .  It develops into a somatic muscle myotube via fusion with `fusion component myoblasts` (CL:0000621)."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1267853", "l": "Lymphocyte positive for CD7 antigen and negative for CD3 antigen", "d": []}, {"i": "SNOMEDCT:116840009", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C0598786", "l": "Ground Glass Hepatocyte", "d": []}, {"i": "NCIT:C83011", "l": "Ground Glass Hepatocyte", "d": ["An abnormally large hepatocyte with eosinophilic or pale, glassy cytoplasm and peripherally displaced nucleus.  This appearance is due to hyperplasia of the smooth endoplasmic reticulum."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2709137", "l": "Frozen packed erythrocytes", "d": []}]}
{"type": "biolink:Cell", "ic": "85.457082654197222", "identifiers": [{"i": "CL:0002033", "l": "short term hematopoietic stem cell", "d": ["A hematopoietic stem cell capable of rapid replenishment of myeloerythroid progenitors and limited self renewal capability. This cell is Kit-positive, Sca1-positive, CD34-positive, CD150-positive, and is Flt3-negative."]}]}
{"type": "biolink:Cell", "ic": "85.457082654197222", "identifiers": [{"i": "CL:0000613", "l": "basophil progenitor cell", "d": ["A progenitor cell committed to the basophil lineage. This cell lacks hematopoietic lineage markers (lin-negative) and is CD34-positive, T1/ST2-low, CD117-negative, and FceRIa-high. This cell also expresses Gata-1, Gata-2 and C/EBPa."]}]}
{"type": "biolink:Cell", "ic": "78.695011174409487", "identifiers": [{"i": "CL:0012001", "l": "neuron of the forebrain", "d": ["A CNS neuron of the forebrain."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1622423", "l": "polymorphonuclear granulocyte", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4055426", "l": "autologous anti-NY-ESO-1/LAGE-1 TCR-transduced c259 T lymphocytes", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:4033005", "l": "serous secreting cell of bronchus submucosal gland", "d": ["A(n) serous secreting cell that is part of a(n) bronchus submucosal gland."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5171659", "l": "Lymphocytes | Body fluid | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "ic": "88.140761698499901", "identifiers": [{"i": "CL:0002012", "l": "Kit-low proerythroblast", "d": ["A proerythoblast that is Kit-low, Lyg76-positive, and CD71-positive."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2334580", "l": "Enterocyte of epithelium of duodenal gland", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:2000081", "l": "melanocyte of skin of face", "d": ["Any melanocyte of skin that is part of a skin of face."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002509", "l": "CD103-positive, langerin-positive lymph node dendritic cell", "d": ["A langerin-positive lymph node dendritic cell that is CD103-positive and CD11b-low."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157462", "l": "CD3+CD8+CD45RO+ cells | Blood | Cell markers", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2340517", "l": "Type 2 vestibular sensory cell of stato-acoustic epithelium", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5170933", "l": "Leukocytes | Pericardial fluid | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5185096", "l": "Viable CD34 cells | Body fluid | Cell markers", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5216207", "l": "Erythrocytes.nucleated|NCnc|Pt|Body fld", "d": []}]}
{"type": "biolink:Cell", "ic": "87.120474278337809", "identifiers": [{"i": "CL:4023027", "l": "L5 sst T-Martinotti interneuron (Mmus)", "d": ["A sst GABAergic cortical interneuron with a soma found in L5 and possesses 'T-shaped' Martinotti morphologies with local axonal plexus in L5a and translaminar axons restricted to the uppermost part of L1. They show low-threshold spiking patterns with strong rebound firing, and inhibit the L1 apical tuft of nearby pyramidal cells."]}]}
{"type": "biolink:Cell", "ic": "92.728541327098611", "identifiers": [{"i": "CL:0002412", "l": "Vgamma1.1-positive, Vdelta6.3-positive thymocyte", "d": ["A gamma-delta receptor that expresses Vgamma1.1-Vdelta6.3 chains in the T-cell receptor."]}]}
{"type": "biolink:Cell", "ic": "76.659841615658792", "identifiers": [{"i": "CL:1001433", "l": "epithelial cell of exocrine pancreas", "d": ["An epithelial cell of the exocrine pancreas."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1956319", "l": "Common Myeloid Progenitors", "d": []}]}
{"type": "biolink:Cell", "ic": "73.721563224321088", "identifiers": [{"i": "CL:1000510", "l": "kidney glomerular epithelial cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4740202", "l": "Cells.CD14-FLAER-", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0000516", "l": "perineuronal satellite cell", "d": ["A non-neuronal cell that surrounds the neuronal cell bodies of the ganglia."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0882931", "l": "Cells.CD8+CD25+", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0011028", "l": "olfactory ensheathing cell", "d": []}]}
{"type": "biolink:Cell", "ic": "70.75272396535307", "identifiers": [{"i": "UMLS:C0031307", "l": "Phagocytes", "d": []}, {"i": "NCIT:C12657", "l": "Phagocytic Cell", "d": []}, {"i": "MESH:D010586", "l": "Phagocytes", "d": []}, {"i": "SNOMEDCT:73568005", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002330", "l": "undifferentiated cell of bronchus epithelium", "d": ["An undifferentiated columnar cell of the bronchus epithelium"]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1267985", "l": "Lymphocyte positive for CD98 antigen", "d": []}, {"i": "SNOMEDCT:117425007", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2350468", "l": "Lymphocyte-Activated Killer Cells", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C3282454", "l": "HUMAN CORD BLOOD HEMATOPOIETIC PROGENITOR CELL 500000000 in 25 mL INTRAVENOUS INJECTION [HemaCord]", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157304", "l": "CD138 cells | Blood | Cell markers", "d": []}]}
{"type": "biolink:Cell", "ic": "75.42073205405498", "identifiers": [{"i": "UMLS:C0026473", "l": "Monocytes", "d": []}, {"i": "NCIT:C12547", "l": "Monocyte", "d": ["Large, phagocytic mononuclear leukocytes produced in the vertebrate bone marrow and released into the blood; contain a large, oval or somewhat indented nucleus surrounded by voluminous cytoplasm and numerous organelles."]}, {"i": "MESH:D009000", "l": "Monocytes", "d": []}, {"i": "SNOMEDCT:55918008", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5447838", "l": "Allogeneic Anti-CD19-CAR-CD28-IL-15-expressing Natural Killer T-cells", "d": []}, {"i": "NCIT:C177533", "l": "Allogeneic Anti-CD19-CAR-CD28-IL-15-expressing Natural Killer T-cells", "d": ["A preparation of allogeneic natural killer T-lymphocytes (NKTs) that have been engineered to express a chimeric antigen receptor (CAR) specific for the human tumor associated antigen (TAA) CD19, interleukin 15 (IL-15) and the costimulatory T-cell-specific surface glycoprotein CD28, with potential immunostimulating and antineoplastic activities. Upon administration, allogeneic anti-CD19-CAR-CD28-IL-15-expressing NKTs target, bind to, and induce selective toxicity in CD19-expressing tumor cells. IL-15 is a pro-survival cytokine that promotes T-cell persistence and potentiates the immune response against tumor cells. CD28 costimulatory molecule enhances activation and signaling after recognition of CD19, and may increase proliferation of T-cells and antitumor activity. CD19 antigen is a B-cell specific cell surface antigen overexpressed in B-cell lineage malignancies."]}]}
{"type": "biolink:Cell", "ic": "84.75972595860604", "identifiers": [{"i": "CL:0002034", "l": "long term hematopoietic stem cell", "d": ["A hematopoietic stem cell with long term self renewal capability. This cell is Kit-positive, Sca1-positive, CD150-positive, CD90-low, CD34-negative and Flt3-negative."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157545", "l": "CD4+CD45RA+CD45RB+CD45RC+ cells | Body fluid | Cell markers", "d": []}]}
{"type": "biolink:Cell", "ic": "87.120474278337809", "identifiers": [{"i": "UMLS:C1514037", "l": "Neoplastic Myeloblast without Azurophilic Granules", "d": []}, {"i": "NCIT:C37179", "l": "Neoplastic Myeloblast without Azurophilic Granules", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1979664", "l": "Cells.CD13+CD33+HLA-DR+", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0600531", "l": "U937 Cells", "d": []}, {"i": "MESH:D020298", "l": "U937 Cells", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1267894", "l": "Lymphocyte positive for both CD22 antigen and CD19 antigen", "d": []}, {"i": "SNOMEDCT:117567000", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5706469", "l": "Autologous Anti-CD19 CAR-expressing T-lymphocytes UF-KURE19", "d": []}, {"i": "NCIT:C188238", "l": "Autologous Anti-CD19 CAR-expressing T-lymphocytes UF-KURE19", "d": ["A preparation of autologous T-lymphocytes that have been genetically modified and transduced with a lentiviral vector to express a chimeric antigen receptor (CAR) that targets the human tumor-associated antigen (TAA) CD19, with potential immunostimulating and antineoplastic activities. Upon administration, autologous anti-CD19 CAR-expressing T-lymphocytes UF-KURE19 bind to and induce selective toxicity against CD19-expressing tumor cells. The CD19 antigen is a B-cell-specific cell surface antigen expressed in all B-cell lineage malignancies."]}]}
{"type": "biolink:Cell", "ic": "64.546003967123667", "identifiers": [{"i": "UMLS:C1882057", "l": "Neoplastic Neuroendocrine Small Cell", "d": []}, {"i": "NCIT:C60534", "l": "Neoplastic Neuroendocrine Small Cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157565", "l": "CD42 cells | Blood | Cell markers", "d": []}]}
{"type": "biolink:Cell", "ic": "72.370703631459492", "identifiers": [{"i": "CL:4023111", "l": "cerebral cortex pyramidal neuron", "d": ["A pyramidal neuron with soma located in the cerebral cortex."]}]}
{"type": "biolink:Cell", "ic": "90.82444074280258", "identifiers": [{"i": "CL:1000275", "l": "smooth muscle cell of small intestine", "d": ["A smooth muscle cell that is part of the small intestine."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C4764285", "l": "Autologous Cytoplasmic Activated PD-1 CAR T-cells", "d": []}, {"i": "NCIT:C158599", "l": "Autologous Cytoplasmic Activated PD-1 CAR T-cells", "d": ["A preparation of autologous T-lymphocytes engineered to express a chimeric antigen receptor (CAR) specific for the tumor-associated antigen (TAA) cluster of differentiation 19 (CD19), carrying cytoplasmic activated programmed cell death 1 (PD1; PDCD1; CD279; programmed death-1), with potential antineoplastic activity. Upon intravenous administration, autologous cytoplasmic activated PD-1 CAR T-cells target, bind to, and induce selective toxicity in CD19-expressing tumor cells. The cytoplasmic activated PD1, a negative immunoregulatory human cell surface receptor, normally binds to programmed cell death-1 ligand 1 (PD-L1; cluster of differentiation 274; CD274) on tumor cells, causing T-cell inactivation. By preventing PD1/PD-L1 signaling, T-cell exhaustion is abrogated, and T-cell activation is enhanced leading to an increased cytotoxic T-lymphocyte (CTL)-mediated anti-tumor immune response against PD-L1-expressing tumor cells. CD19 is a B-cell-specific cell surface antigen overexpressed in B-cell lineage tumors."]}]}
{"type": "biolink:Cell", "ic": "76.10017597303252", "identifiers": [{"i": "UMLS:C0598800", "l": "Pericytes", "d": []}, {"i": "NCIT:C12656", "l": "Pericyte", "d": ["A multipotent perivascular cell that is embedded in the basement membrane of capillaries and contributes to tissue repair in response to injury."]}, {"i": "MESH:D020286", "l": "Pericytes", "d": []}, {"i": "SNOMEDCT:34773004", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0229952", "l": "Thymic reticulum cell", "d": []}, {"i": "SNOMEDCT:50482005", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0546494", "l": "P.B. eosinophilic metamyelocyte", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1148326", "l": "CD25 cells", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C4527154", "l": "TCR-specific, alpha Fetoprotein-enhanced Autologous T Lymphocytes", "d": []}, {"i": "NCIT:C136982", "l": "TCR-specific, alpha Fetoprotein-enhanced Autologous T Lymphocytes", "d": ["A preparation of human autologous T-lymphocytes transduced with a viral vector encoding for a T-cell receptor (TCR) specific for human alpha-fetoprotein (AFP), with potential antineoplastic activity. Following administration, the TCR-specific, alpha fetoprotein-enhanced autologous T-lymphocytes recognize and bind to AFP antigen-positive cells, which results in lysis and killing of AFP-positive cancer cells. AFP is overexpressed in a variety of cancers."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C4086000", "l": "Autologous Anti-CD19 CAR-expressing T Lymphocytes", "d": []}, {"i": "NCIT:C125691", "l": "Autologous Anti-CD19 CAR-expressing T Lymphocytes", "d": ["A preparation of autologous T-lymphocytes that have been genetically modified to express a chimeric antigen receptor (CAR) that targets the human tumor associated antigen (TAA) CD19, with potential immunostimulating and antineoplastic activities. Upon administration, autologous anti-CD19 CAR-expressing T lymphocytes bind to and induce selective toxicity against CD19-expressing tumor cells. CD19 antigen is a B-cell specific cell surface antigen expressed in all B-cell lineage malignancies."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5163550", "l": "Epithelial cells.non-squamous | Urine sediment | Urinalysis", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:1000298", "l": "mesothelial cell of dura mater", "d": ["A mesothelial cell that is part of the dura mater."]}]}
{"type": "biolink:Cell", "ic": "92.728541327098611", "identifiers": [{"i": "UMLS:C1709677", "l": "Bone Marrow Myeloid Stem Cell with Some Degree of Commitment to the Erythroid Lineage", "d": []}, {"i": "NCIT:C43220", "l": "Bone Marrow Myeloid Stem Cell with Some Degree of Commitment to the Erythroid Lineage", "d": []}]}
{"type": "biolink:Cell", "ic": "87.120474278337809", "identifiers": [{"i": "CL:0005006", "l": "ionocyte", "d": ["Specialized epithelial cells involved in the maintenance of osmotic homeostasis. They are characterized by abundant mitochondria and ion transporters. In amniotes, they are present in the renal system. In freshwater fish, ionocytes in the skin and gills help maintain osmotic homeostasis by absorbing salt from the external environment."]}]}
{"type": "biolink:Cell", "ic": "89.347505587204751", "identifiers": [{"i": "UMLS:C1709194", "l": "Neoplastic Plump Endothelial Cell", "d": []}, {"i": "NCIT:C53305", "l": "Neoplastic Plump Endothelial Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C4733634", "l": "Autologous CCR4-CD30CAR-CD28-CD3zeta-expressing T-Lymphocytes", "d": []}, {"i": "NCIT:C155293", "l": "Autologous CCR4-CD30CAR-CD28-CD3zeta-expressing T-Lymphocytes", "d": ["A preparation of autologous T-lymphocytes (ATL) that have been transduced with the retroviral vector SFG, a Moloney murine leukemia (Mo-MuLV) virus-based vector, encoding human C-C chemokine receptor 4 (CCR4), linked via an internal ribosome entry site (IRES), to a chimeric antigen receptor (CAR) composed of a single chain single-chain variable fragment (scFv) directed against the CD30 antigen (CAR.CD30) and linked, via the spacer human IgG1 immunoglobulin heavy constant region (hinge-CH2CH3 region), to the co-stimulatory domains of CD28 and the zeta chain of the TCR/CD3 complex (CD3-zeta) (CD28zeta), with potential immunostimulating and antineoplastic activities. Upon administration of the autologous CCR4-CD30CAR-CD28-CD3zeta-expressing T-lymphocytes, the expressed CCR4 on the T-cells allows for enhanced migration of the cells to chemokine-secreting tumor cells. The expressed CAR.CD30 moiety specifically recognizes and binds to CD30-expressing tumor cells, resulting in specific T-cell-mediated tumor cell lysis. CD30, a cell surface receptor and a member of the tumor necrosis factor (TNF) receptor superfamily, is transiently expressed on activated lymphocytes and is constitutively expressed in hematologic malignancies. CCR4, a G-coupled-protein receptor for C-C chemokines normally expressed on regulatory T-cells (Tregs) but not on cytotoxic T-lymphocytes (CTLs), is involved in chemokine-mediated cellular migration. The co-expression of CCR4 on these CTLs may enhance their anti-tumor activity compared to T-lymphocytes expressing the same CAR-CD30 receptor but without CCR4 expression."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C0682695", "l": "Renshaw Cells", "d": []}, {"i": "NCIT:C33463", "l": "Renshaw Cell", "d": ["An inhibitory interneuron in the ventral horn of gray matter of the spinal cord that is held to be reciprocally innervated with a motoneuron so that nerve impulses received by way of processes of the motoneuron stimulate inhibitory impulses back to the motoneuron along an axon of the internuncial cell."]}, {"i": "MESH:D066293", "l": "Renshaw Cells", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5380985", "l": "Cells.CD8.HLA-A1 CMV specific", "d": []}]}
{"type": "biolink:Cell", "ic": "83.023198044254755", "identifiers": [{"i": "CL:1001516", "l": "intestinal enteroendocrine cell", "d": ["The various hormone- or neurotransmitter-secreting cells present throughout the mucosa of the intestinal tract."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C4727163", "l": "Autologous Tumor Infiltrating Lymphocytes MDA-TIL", "d": []}, {"i": "NCIT:C153312", "l": "Autologous Tumor Infiltrating Lymphocytes MDA-TIL", "d": ["A preparation of autologous tumor infiltrating lymphocytes (TILs) with potential antineoplastic activity. TILs are isolated from a patient's tumor tissue, then cultured and expanded in vitro in the presence of interleukin-2 (IL-2) and an agonistic anti-4-1BB (CD137) antibody. Upon infusion of the autologous expanded TILs back into the patient, the cells specifically recognize, target, and kill the patient's tumor cells."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1181474", "l": "Chromaffin cell of adrenal medulla", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1517819", "l": "Mouse Pro-B-Lymphocyte", "d": []}, {"i": "NCIT:C22575", "l": "Mouse Pro-B-Lymphocyte", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:2000012", "l": "fibroblast of pedal digit skin", "d": ["Any skin fibroblast that is part of a pedal digit skin."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157518", "l": "CD3-CD16+ cells | Tissue and Smears | Cell markers", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C3641664", "l": "Autologous Bone Marrow-derived CD34/CXCR4-positive Stem Cells AMR-001", "d": []}, {"i": "NCIT:C103865", "l": "Autologous Bone Marrow-derived CD34/CXCR4-positive Stem Cells AMR-001", "d": ["A cell-based product containing autologous bone marrow derived CD34 positive and C-X-C chemokine receptor type 4 (CXCR4) positive stem cells with potential antiapoptotic and proangiogenic activities. Upon intracoronary infusion after a myocardial infarction (MI), autologous bone marrow-derived CD34/CXCR4-positive stem cells may preserve cardiac muscle cells and prevent apoptosis; thus improving myocardial perfusion. CD34/CXCR4-positive stem cells are naturally mobilized upon cell injury through signaling by hypoxia inducing factor (HIF), which is secreted in response to hypoxia. In turn, HIF induces the synthesis of stromal-derived factor 1 (SDF-1) and vascular endothelial growth factor (VEGF) which mobilize CD34/CXCR4 positive stem cells; CXCR4 is the receptor for stromal-derived factor 1 (SDF-1)."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:2000095", "l": "cord blood hematopoietic stem cell", "d": ["Any hematopoietic stem cell that is part of a umbilical cord blood."]}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "CL:2000011", "l": "dermis lymphatic vessel endothelial cell", "d": ["Any endothelial cell of lymphatic vessel that is part of a dermis."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1440401", "l": "Cells.t(11;22)(q24;q12.2)(FLI1,EWSR1)", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5381002", "l": "Cells.CD8.HLA-A2 CMV specific", "d": []}]}
{"type": "biolink:Cell", "ic": "74.240948556675605", "identifiers": [{"i": "UMLS:C1709183", "l": "Neoplastic Lipoblast", "d": []}, {"i": "NCIT:C48878", "l": "Neoplastic Lipoblast", "d": []}]}
{"type": "biolink:Cell", "ic": "72.370703631459492", "identifiers": [{"i": "CL:0008026", "l": "open tracheal system tracheocyte", "d": ["An epithelial cell that is part of the epithelium of a tracheal tube in an open tracheal system, such as that found in insects."]}]}
{"type": "biolink:Cell", "ic": "53.819001072360145", "identifiers": [{"i": "UMLS:C0039194", "l": "T-Lymphocyte", "d": []}, {"i": "NCIT:C12476", "l": "T-Lymphocyte", "d": ["A thymocyte-derived lymphocyte of immunological importance that is long-lived (months to years) and is responsible for cell-mediated immunity. T lymphocyte cells form rosettes with sheep erythrocytes and, in the presence of transforming agents (mitogens), differentiate and divide. These cells have the characteristic T3 surface marker and may be further divided into subsets according to function, such as helper, cytotoxic, etc."]}, {"i": "MESH:D013601", "l": "T-Lymphocytes", "d": []}, {"i": "SNOMEDCT:57184004", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C3899992", "l": "Autologous TNS9.3.55-transduced CD34-positive Cells", "d": []}, {"i": "NCIT:C116734", "l": "Autologous TNS9.3.55-transduced CD34-positive Cells", "d": ["A preparation of autologous, CD34-positive hematopoietic progenitor cells (HPCs) ex vivo transduced with TNS9.3.55, a lentiviral vector encoding the human beta-globin (hemoglobin-beta, HBB) gene, with potential to restore beta-globin expression and function. Autologous CD34-positive stem cells are isolated from the patient's own bone marrow, the deficient HBB gene is removed, and the cells are transduced with the lentiviral vector. Upon re-infusion of the TNS9.3.55-transduced CD34-positive cells back into the patient, these cells express beta-globin, thereby allowing the body to make normal hemoglobin and thus normal, healthy red blood cells. Beta-globin, the beta-chain of the most common form of hemoglobin, is encoded by the HBB gene; mutations in this gene prevent normal beta-globin production."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5572244", "l": "Siderocytes | Blood or Marrow | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:1001108", "l": "kidney loop of Henle medullary thick ascending limb epithelial cell", "d": ["An epithelial cell that is part of some loop of Henle thick ascending limb segment located in the renal medulla."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4300406", "l": "Cells.chromosome region 11q22.3", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1519477", "l": "Splenocyte", "d": []}, {"i": "NCIT:C12951", "l": "Splenocyte", "d": ["A vague term that usually refers to the phagocytic cells (macrophages) of the spleen."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C3496154", "l": "Aaq dopamine cells", "d": []}]}
{"type": "biolink:Cell", "ic": "66.748105804263417", "identifiers": [{"i": "CL:1000449", "l": "epithelial cell of nephron", "d": ["An epithelial cell that is part of the nephron."]}]}
{"type": "biolink:Cell", "ic": "71.163959742754642", "identifiers": [{"i": "UMLS:C1514092", "l": "Neoplastic Small Round Cell", "d": []}, {"i": "NCIT:C37100", "l": "Neoplastic Small Round Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "92.728541327098611", "identifiers": [{"i": "UMLS:C1711306", "l": "Malignant Thyroid Gland Follicular Clear Cell", "d": []}, {"i": "NCIT:C47821", "l": "Malignant Thyroid Gland Follicular Clear Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "68.042516761614237", "identifiers": [{"i": "CL:0010021", "l": "cardiac myoblast", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1267998", "l": "Lymphocyte positive for CD120A antigen", "d": []}, {"i": "SNOMEDCT:117438004", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002183", "l": "stem cell of gastric gland", "d": ["A stomach epithelial cell that is olumnar in form with a few short apical microvilli; relatively undifferentiated mitotic cell from which other types of gland are derived; few in number, situated in the isthmus region of the gland and base of the gastric pit."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4072765", "l": "Cells.ALK gene rearrangements", "d": []}]}
{"type": "biolink:Cell", "ic": "69.196521192641157", "identifiers": [{"i": "UMLS:C1709176", "l": "Neoplastic Follicle Center B-Cell", "d": []}, {"i": "NCIT:C45317", "l": "Neoplastic Follicle Center B-Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:1000322", "l": "pancreatic goblet cell", "d": ["A goblet cell that is part of the epithelium of pancreatic duct."]}]}
{"type": "biolink:Cell", "ic": "86.236661114203869", "identifiers": [{"i": "CL:0000026", "l": "invertebrate nurse cell", "d": ["A germline cell that contributes to the development of the oocyte by transferring cytoplasm directly to oocyte."]}]}
{"type": "biolink:Cell", "ic": "88.140761698499901", "identifiers": [{"i": "UMLS:C1516943", "l": "Epithelial Receptor Cell", "d": []}, {"i": "NCIT:C13145", "l": "Epithelial Receptor Cell", "d": ["A cell on the surface of the body or lining a body cavity that responds to physical and chemical stimuli by sending information to the central nervous system."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0004126", "l": "retinal ganglion cell C2 outer", "d": ["A retinal ganglion cell C outer that has symmetrical and dense dendritic dendritic tree with a large dendritic field."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5216298", "l": "Nucleated cells|NCnc|Pt|Bone mar", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5151349", "l": "Abnormal lymphocytes | Body fluid | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5447578", "l": "Iltamiocel", "d": []}, {"i": "NCIT:C177094", "l": "Iltamiocel", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5205480", "l": "Autologous Anti-BCMA CAR T-cells IM21", "d": []}, {"i": "NCIT:C160704", "l": "Autologous Anti-BCMA CAR T-cells IM21", "d": ["A preparation of autologous T-lymphocytes that have been transduced with a lentiviral vector (LV) expressing a chimeric antigen receptor (CAR) targeting the human tumor-associated antigen (TAA) B-cell maturation antigen (BCMA; tumor necrosis factor receptor superfamily member 17; TNFRSF17) and containing, as of yet undisclosed costimulatory signaling domains, with potential antineoplastic activity. Upon administration, the autologous anti-BCMA CAR T-cells IM21 recognize and induce selective toxicity against BCMA-expressing tumor cells. BCMA, a tumor-specific antigen and a receptor for both a proliferation-inducing ligand (APRIL) and B-cell activating factor (BAFF), is a member of the tumor necrosis factor receptor superfamily (TNFRSF) and plays a key role in plasma cell survival. BCMA is found on the surfaces of plasma cells and is overexpressed on malignant plasma cells."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5690793", "l": "Medium Spiny Neurons", "d": []}, {"i": "MESH:D000094242", "l": "Medium Spiny Neurons", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1709904", "l": "Renal Tumor-Reactive Autologous Tumor Infiltrating Lymphocyte", "d": []}, {"i": "NCIT:C48817", "l": "Renal Tumor-Reactive Autologous Tumor Infiltrating Lymphocyte", "d": ["Tumor infiltrating lymphocytes (TIL) harvested directly from infiltrate of a patient's renal tumor and cultured with interleukin-2 to expand the TIL cell population. Tumor infiltrating lymphocytes have specific activity against the tumor from which they are derived. Introducing these renal tumor-reactive autologous tumor infiltrating lymphocytes back into the same patient may enhance a cytotoxic T-cell-mediated immune response against the renal cancer cells."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1267887", "l": "CD19+SMIG KAPPA+ lymphocyte", "d": []}, {"i": "SNOMEDCT:117563001", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0443611", "l": "Fat globule", "d": []}, {"i": "SNOMEDCT:259580005", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4697024", "l": "Cells.CD27+IgD+IgM+", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4518151", "l": "Population of all spermatozoa with angled midpiece in portion of fluid", "d": []}, {"i": "SNOMEDCT:725236008", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2335706", "l": "Interleukin 2-activated natural killer cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0814990", "l": "neural cell line", "d": []}]}
{"type": "biolink:Cell", "ic": "80.511444690059548", "identifiers": [{"i": "UMLS:C1882063", "l": "Nephrogenic Blastemal Cell", "d": []}, {"i": "NCIT:C61287", "l": "Nephrogenic Blastemal Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5419552", "l": "Buccal Cell Sample", "d": []}, {"i": "NCIT:C172264", "l": "Buccal Cell Sample", "d": ["A sample comprised of cells collected from the inside of a subject's cheek."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0000554", "l": "gastrin stimulating hormone secreting cell", "d": ["A peptide hormone secreting cell that secretes gastrin stimulating hormone."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157611", "l": "CD55 Granulocytes | Blood | Cell markers", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1513176", "l": "Metaplastic Squamous Cell", "d": []}, {"i": "NCIT:C36817", "l": "Metaplastic Squamous Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "CL:0002093", "l": "secondary polar body", "d": ["A small cell formed by the second meiotic division of oocytes. In mammals, the second polar body may fail to form unless the ovum has been penetrated by a sperm cell."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5216241", "l": "Leukocytes|NCnc|Pt|Synv fld", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5222944", "l": "CD3- CD16+ cells/100 cells in blood", "d": []}]}
{"type": "biolink:Cell", "ic": "92.728541327098611", "identifiers": [{"i": "CL:4023188", "l": "midget ganglion cell of retina", "d": ["A retinal ganglion cell that originate in the ganglion cell layer of the retina, and project to the parvocellular layers of the lateral geniculate nucleus (LGN). These cells are known as midget retinal ganglion cells due to the small sizes of their dendritic trees and cell bodies."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5238924", "l": "Circulating Cancer-Associated Fibroblast", "d": []}, {"i": "NCIT:C168535", "l": "Circulating Cancer-Associated Fibroblast", "d": ["A fibroblast found in the peripheral blood that is associated with a neoplastic disease and may colocalize with circulating tumor cells."]}]}
{"type": "biolink:Cell", "ic": "73.597844352697123", "identifiers": [{"i": "CL:0000016", "l": "male germ line stem cell", "d": ["A stem cell that is the precursor of male gametes."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002356", "l": "primitive reticulocyte", "d": ["A primitive erythrocyte that has undergone enucleation. This cell type is 3-6 fold bigger than the fetal derived erythrocytes that they co-circulate with during fetal development. Expresses epsilon-gamma hemoglobin chains."]}]}
{"type": "biolink:Cell", "ic": "90.82444074280258", "identifiers": [{"i": "CL:0002015", "l": "Kit-negative, Ly-76 high polychromatophilic erythroblast", "d": ["A polychromatophilic erythroblast that is Lyg 76-high and is Kit-negative."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:2000015", "l": "fibroblast of arm", "d": ["Any skin fibroblast that is part of a arm."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1267912", "l": "Lymphocyte positive for CD35 antigen", "d": []}, {"i": "SNOMEDCT:117035005", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0230521", "l": "Mitotic cell in anaphase", "d": []}, {"i": "SNOMEDCT:7566005", "d": []}]}
{"type": "biolink:Cell", "ic": "54.473960314480166", "identifiers": [{"i": "CL:0002032", "l": "hematopoietic oligopotent progenitor cell", "d": ["A hematopoietic oligopotent progenitor cell that has the ability to differentiate into limited cell types but lacks lineage cell markers and self renewal capabilities."]}]}
{"type": "biolink:Cell", "ic": "86.236661114203869", "identifiers": [{"i": "UMLS:C1513968", "l": "Neoplastic Follicular Dendritic Cell", "d": []}, {"i": "NCIT:C36893", "l": "Neoplastic Follicular Dendritic Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C4289596", "l": "Effector Memory T Cells", "d": []}, {"i": "NCIT:C126419", "l": "Effector Memory T-Lymphocyte", "d": ["Long-lived antigen-specific T-lymphocytes, which express CD8 and effector cytokines. Upon subsequent exposure to their target antigen, these cells rapidly become effector cells."]}]}
{"type": "biolink:Cell", "ic": "90.82444074280258", "identifiers": [{"i": "CL:0002535", "l": "epithelial cell of cervix", "d": ["An epithelial cell of the cervix."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5216243", "l": "Lymphocytes.abnormal|NCnc|Pt|Bld", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1440316", "l": "Cells.CD45RB", "d": []}]}
{"type": "biolink:Cell", "ic": "80.17194633000733", "identifiers": [{"i": "UMLS:C1513953", "l": "Neoplastic Endocrine Clear Cell", "d": []}, {"i": "NCIT:C36930", "l": "Neoplastic Endocrine Clear Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5555570", "l": "Anti-CD79b CAR T Cells", "d": []}, {"i": "NCIT:C179270", "l": "Anti-CD79b CAR T Cells", "d": ["A preparation of T-lymphocytes that have been genetically modified to express a chimeric antigen receptor (CAR) targeting the tumor-associated antigen (TAA) B-cell antigen receptor complex-associated protein beta chain (CD79b; B-cell-specific glycoprotein B29), with potential immunostimulating and antineoplastic activities. Upon administration, anti-CD79b CAR T cells target and bind to CD79b-expressing tumor cells, thereby inducing selective toxicity in CD79b-expressing tumor cells. CD79b, a critical receptor for successful B cell development and part of the B cell receptor (BCR) signaling complex, is widely expressed in certain subtypes of B cell lymphomas."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C4329372", "l": "Autologous PD-1-targeted Chimeric Switch Receptor-modified T Lymphocytes", "d": []}, {"i": "NCIT:C132251", "l": "Autologous PD-1-targeted Chimeric Switch Receptor-modified T Lymphocytes", "d": ["Autologous human T-lymphocytes that are genetically engineered to express a chimeric switch receptor (CSR) composed of the extracellular ligand binding domain of the human inhibitory receptor programmed cell death protein 1 (PD-1; PDCD1) fused to the transmembrane and cytoplasmic co-stimulatory signaling domains of CD28 (PD1CD28; PD-1:CD28 switch receptor), with potential immunomodulating and antineoplastic activities. Upon reintroduction of autologous PD-1-targeted CSR-modified T-lymphocytes into the patient, the switch receptor expressed by the engineered T-cells targets and binds to the PD-1 ligands, programmed cell death ligand 1 (PD-L1) and 2 (PD-L2) expressed, on tumor cells. The nature of the PD-1/CD28 switch receptor fusion protein prevents the normal PD1/PD-L1-mediated T-cell suppression and, instead, promotes signaling through the CD28 domain, which results in the stimulation of T-lymphocytes. This induces enhanced toxicity against PD-L1-expressing tumor cells. PD-1 protein, found on activated T-cells, negatively regulates T-cell activity; it plays a key role in immune evasion and prevents tumor cell lysis. Exchanging the transmembrane and intracellular domain of PD-1 with that of CD28 converts PD-L1 into a co-stimulation ligand of primary human CD8+ cytotoxic T-lymphocytes (CTLs). CD28, is a molecule expressed by T-cells that stimulates increased T-lymphocyte proliferation and activity."]}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "CL:4023005", "l": "dynamic nuclear bag fiber", "d": ["A nuclear bag fiber that is sensitive mainly to the rate of change in muscle length."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1520105", "l": "Wisconsin H13 stem cell line", "d": []}, {"i": "NCIT:C20311", "l": "WA13", "d": ["Provider: Wisconsin Alumni Research Foundation (WARF), Madison, WI. Information from provider and not independently verified by NIH: Cells are positive for cell markers SSEA-3, SSEA-4, TRA-1-60, TRA-1-81, and alkaline phosphatase; Cells are negative for SSEA-1; Give rise to teratomas containing derivatives of three germ layers in SCID mice; Differentiate in vitro; Cells not yet ready for distribution. Publication: Thomson et al., Science 282, 1145, 1998. This cell line meets the criteria for the use of human embryonic stem cells by federally funded researchers."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5173468", "l": "Monocytes+Macrophages | Cerebral spinal fluid | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0011014", "l": "non-motile sperm cell", "d": ["A sperm cell that is not cabaple of motion (motility)."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C4329368", "l": "Autologous Bladder Cell Carcinoma RNAs/CD40L RNA Electroporated Autologous Matured Dendritic Cells", "d": []}, {"i": "NCIT:C129522", "l": "Autologous Bladder Cell Carcinoma RNAs/CD40L RNA Electroporated Autologous Matured Dendritic Cells", "d": ["A cell-based preparation in which autologous, mature dendritic cells (DCs) are electroporated with in vitro transcribed (IVT) RNAs encoding for a synthetic form of T-cell protein CD40 ligand (CD40L) and IVT RNA encoding for autologous tumor-associated antigens (TAAs) derived from patient-specific bladder cell carcinoma (BCC) cells, with potential immunostimulatory and antineoplastic activities. Upon electroporation into autologous DCs, the RNA is translated and processed. BCC-specific antigenic peptides are subsequently presented via major histocompatibility complex (MHC) Class I molecules on the DCs surface. When AGS-003-BLD is reintroduced to the patient, the MHC-presented peptides interact with and activate CD8-positive T-cells, which elicits a highly specific cytotoxic T-cell (CTL) response against tumor cells expressing the patient-specific BCC TAAs. The signal cascade initiated by expression of the co-stimulatory molecule CD40L results in the secretion of the inflammatory cytokine IL-12, which further stimulates CTLs."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:1001005", "l": "glomerular capillary endothelial cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0682690", "l": "primary sensory neuron", "d": []}]}
{"type": "biolink:Cell", "ic": "92.728541327098611", "identifiers": [{"i": "UMLS:C1708922", "l": "Malignant Transitional Cell with Clear Cytoplasm", "d": []}, {"i": "NCIT:C54561", "l": "Malignant Transitional Cell with Clear Cytoplasm", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5182767", "l": "T-cell naive and memory and effector (CD27 and CD45RA) subsets | Blood | Cell markers", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C3496264", "l": "B1 serotonin cells", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1515636", "l": "gp100 Peptide-sensitized Autologous T-cells (CD4+ and CD8+)", "d": []}, {"i": "NCIT:C29556", "l": "gp100 Peptide-sensitized Autologous T-cells (CD4+ and CD8+)", "d": ["A population of CD4+ and CD8+ T-cells isolated from a cancer patient that have been sensitized in vitro to the melanoma-associated antigen gp100.  Infusion of gp100 peptide-sensitized autologous T-cells into the cancer patient may stimulate the host immune system to mount a cytotoxic T lymphocyte (CTL) response against gp100-positive tumor cells, thereby decreasing tumor growth. (NCI04)"]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5163558", "l": "Epithelial cells.squamous | Urine sediment | Urinalysis", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1440320", "l": "Cells.CD48", "d": []}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "UMLS:C1513746", "l": "Multinucleated Malignant Squamous Cell", "d": []}, {"i": "NCIT:C36774", "l": "Multinucleated Malignant Squamous Cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5763110", "l": "ALLOGENEIC HUMAN UMBILICAL CORD-DERIVED MESENCHYMAL STEM CELLS", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:1000321", "l": "large intestine crypt goblet cell", "d": ["A goblet cell that is part of the epithelium of crypt of Lieberkuhn of large intestine."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1440319", "l": "Cells.CD47", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0003039", "l": "M8 retinal ganglion cell", "d": ["A monostratified retinal ganglion cell with large soma and medium dendritic field, with dense dendritic arbor."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1440349", "l": "Cells.CD69", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5216244", "l": "Lymphocytes.clefted|NCnc|Pt|Bld", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0011105", "l": "dopamanergic interplexiform cell", "d": ["A type of interneuron in the retinal inner nuclear layer which"]}]}
{"type": "biolink:Cell", "ic": "79.541110464886842", "identifiers": [{"i": "UMLS:C1882046", "l": "Neoplastic Eccrine Cell", "d": []}, {"i": "NCIT:C62495", "l": "Neoplastic Eccrine Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5446527", "l": "Autologous Anti-kappa Light Chain CAR-CD28-expressing T-lymphocytes", "d": []}, {"i": "NCIT:C175446", "l": "Autologous Anti-kappa Light Chain CAR-CD28-expressing T-lymphocytes", "d": ["A preparation of autologous T-lymphocytes (ATL) that have been genetically modified to express a chimeric antigen receptor (CAR) directed against the kappa light chain of immunoglobulin (Ig) and linked to the costimulatory domain of CD28, with potential immunostimulating and antineoplastic activities. Upon administration, the autologous anti-kappa light chain CAR-CD28-expressing T-lymphocytes target and bind to the kappa light chain of Ig expressed on tumor cells, resulting in T-cell-mediated tumor cell lysis. In some B-cell malignancies, the expression of the Ig light chain kappa may be increased compared to the expression of Ig light chain lambda."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1440260", "l": "Cells.CD16b", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1440419", "l": "Cells.t(X;18)(q11.2;p11.23)(SS18,SSX1)", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1514277", "l": "Postradiation Dysplastic Squamous Cell", "d": []}, {"i": "NCIT:C36806", "l": "Postradiation Dysplastic Squamous Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "UMLS:C5446656", "l": "Tall Columnar Adenocarcinoma Cell with Reversed Polarity", "d": []}, {"i": "NCIT:C175606", "l": "Tall Columnar Adenocarcinoma Cell with Reversed Polarity", "d": ["A tall columnar adenocarcinoma cell with its nucleus located at the apical pole of the cell rather than the basal pole."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5448075", "l": "LentiGlobin Drug Product for SCD", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:1000456", "l": "mesothelial cell of parietal peritoneum", "d": ["A mesothelial cell that is part of the parietal peritoneum."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5669239", "l": "Allogeneic Anti-CD5 CAR T Cells", "d": []}, {"i": "NCIT:C184378", "l": "Allogeneic Anti-CD5 CAR T Cells", "d": ["A preparation of allogeneic T-lymphocytes that have been genetically modified to express a chimeric antigen receptor (CAR) specific for CD5, with potential immunomodulating and antineoplastic activities. Upon administration, the allogeneic anti-CD5 CAR T cells target and bind to CD5-expressing tumor cells, thereby inducing selective cytotoxicity in CD5-expressing tumor cells. CD5 is a T-cell surface glycoprotein expressed on the surface of normal T-cells and overexpressed on various B- and T-cell malignancies."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C0085262", "l": "PC12 Cells", "d": []}, {"i": "NCIT:C17435", "l": "PC-12", "d": ["PC-12 adheres poorly to plastic, and tends to grow in small clusters. Attachment is improved by using collagen coated flasks."]}, {"i": "MESH:D016716", "l": "PC12 Cells", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1276850", "l": "Entire parathyroid chief cell", "d": []}, {"i": "SNOMEDCT:177527004", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1522066", "l": "Skin - Epidermis - Basal Cell (MMHCC)", "d": []}, {"i": "NCIT:C22540", "l": "Mouse Basal Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "90.82444074280258", "identifiers": [{"i": "CL:1000549", "l": "kidney cortex collecting duct epithelial cell", "d": []}]}
{"type": "biolink:Cell", "ic": "81.247621244257502", "identifiers": [{"i": "UMLS:C1516859", "l": "Stromal cell of endometrium", "d": []}, {"i": "NCIT:C33921", "l": "Endometrial Stromal Cell", "d": ["A cell of the uterine wall immediately underling the endometrial epithelium. Endometrial stromal cells proliferate and respond to the cyclic variations of estrogen and progesterone. These cells produce growth factors and hormones that mediate the proliferative response of epithelial cells to the steroid hormones estrogen and progesterone. In response to embryo implantation, endometrial stromal cells accumulate lipid and glycogen."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5549345", "l": "Cells.FOXP3", "d": []}]}
{"type": "biolink:Cell", "ic": "89.347505587204751", "identifiers": [{"i": "UMLS:C1518308", "l": "Neutrophil with Pseudo Chediak-Higashi Granules", "d": []}, {"i": "NCIT:C37175", "l": "Neutrophil with Pseudo Chediak-Higashi Granules", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5174645", "l": "Neutrophils.segmented/100 cells | Bone marrow | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0000485", "l": "mucosal type mast cell", "d": ["Mast cell subtype that contains only the serine protease trypase in its granules. These cells are primarily found in mucosal tissue, such as intestinal mucosa and alveoli. They depend upon T-cells for development of phenotype."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1440257", "l": "Cells.CD14+HLA-DR+", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C4733629", "l": "Autologous Cervical Cancer-specific Engineered Immune Effector Cells", "d": []}, {"i": "NCIT:C155657", "l": "Autologous Cervical Cancer-specific Engineered Immune Effector Cells", "d": ["A preparation of autologous immune effector cells genetically modified to target a not yet disclosed cervical cancer-specific tumor-associated antigen (TAA), with potential immunomodulating and antineoplastic activities. After isolation, transduction, expansion in culture, and reintroduction into the patient, the autologous cervical cancer-specific engineered immune effector (CC-EIE) cells bind to and induce selective toxicity in tumor cells expressing the TAA."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5667089", "l": "Allogeneic MUC1-C-specific CAR-T Cells P-MUC1C-ALLO1", "d": []}, {"i": "NCIT:C187029", "l": "Allogeneic MUC1-C-specific CAR-T Cells P-MUC1C-ALLO1", "d": ["An off-the-shelf (OTS) preparation of human allogeneic T-lymphocytes containing primarily stem cell memory T-cells (Tscm) that have been genetically modified to express a chimeric antigen receptor (CAR) specific for the C-terminal subunit of the tumor-associated antigen (TAA) mucin-1 (MUC1-C) and gene-edited to knockout both the T-cell receptor (TCR) and major histocompatibility complex (MHC) class I proteins, with potential immunostimulating and antineoplastic activities. Upon administration, allogeneic MUC1-C-specific CAR-T cells P-MUC1C-ALLO1 specifically recognize and induce selective toxicity in MUC1-C-expressing tumor cells. MUC1, a glycoprotein normally expressed on epithelial cells and overexpressed on the surface of a variety of cancer cells, plays a key role in tumor cell survival and proliferation. The proteolytic cleavage of MUC1 in the tumor microenvironment (TME) leads to the overexpression of MUC1-C in the TME."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0000241", "l": "stratified cuboidal epithelial cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4300320", "l": "100 viable tumor cells", "d": []}]}
{"type": "biolink:Cell", "ic": "82.076046914303362", "identifiers": [{"i": "CL:0002437", "l": "mature CD8 single-positive thymocyte", "d": ["A mature CD8-positive, CD4-negative alpha-beta T cell found in the thymus that is CD24-low and has high expression of the T cell receptor."]}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "UMLS:C1711269", "l": "Neoplastic Lactotroph Cell with Large Secretory Granules", "d": []}, {"i": "NCIT:C45952", "l": "Neoplastic Lactotroph Cell with Large Secretory Granules", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0011106", "l": "GABAnergic interplexiform cell", "d": ["A type of interneuron in the retinal inner nuclear layer which"]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1861193", "l": "THROMBOCYTE B", "d": []}]}
{"type": "biolink:Cell", "ic": "89.347505587204751", "identifiers": [{"i": "CL:0002332", "l": "ciliated cell of the bronchus", "d": ["A ciliated cell of the bronchus."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4697017", "l": "Cells.CD21-", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2350245", "l": "Megakaryocyte Progenitor Cells", "d": []}, {"i": "MESH:D055016", "l": "Megakaryocyte Progenitor Cells", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2340574", "l": "Horizontal cell of cerebral cortex", "d": []}]}
{"type": "biolink:Cell", "ic": "86.236661114203869", "identifiers": [{"i": "CL:1000350", "l": "basal cell of epithelium of terminal bronchiole", "d": ["A basal cell that is part of the epithelium of terminal bronchiole."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5168979", "l": "Immature eosinophils | Blood | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "ic": "74.240948556675605", "identifiers": [{"i": "CL:0000322", "l": "pneumocyte", "d": ["An epithelial cell that lines the peripheral gas exchange region of the lungs of air-breathing vertebrates."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0003033", "l": "M4 retinal ganglion cell", "d": ["A monostratified retinal ganglion cell that has a large soma, a medium dendritic field with post synaptic terminals in sublaminar layer S3."]}]}
{"type": "biolink:Cell", "ic": "82.076046914303362", "identifiers": [{"i": "CL:1001474", "l": "medium spiny neuron", "d": ["An inhibitory, GABAergic projection neuron in the striatum that integrates glutamatergic signals arising from the cerebral cortex and thalamus."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5142688", "l": "Plasma cells.abnormal marker pattern", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:4030049", "l": "striosomal D2 medium spiny neuron", "d": ["A DRD2-expressing medium spiny neuron that is part of a striosome of dorsal striatum."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C4763599", "l": "Autologous Anti-NY-ESO-1 mTCR Retroviral Vector Transduced PBLs", "d": []}, {"i": "NCIT:C157409", "l": "Autologous Anti-NY-ESO-1 mTCR Retroviral Vector Transduced PBLs", "d": ["Human autologous peripheral blood lymphocytes (PBLs) transduced with a retroviral vector encoding both alpha and beta chains of a murine T-cell receptor (mTCR) specific for the cancer-testis antigen NY-ESO-1, with potential antineoplastic activity. Upon isolation, transduction, expansion ex vivo, and reintroduction into the patient, the autologous anti-NY-ESO-1 mTCR retroviral vector transduced PBLs bind to NY-ESO-1 expressed on tumor cells. This may result in cytotoxic T-lymphocyte (CTL)-mediated killing of NY-ESO-1-positive cancer cells. NY-ESO-1, a tumor-associated antigen (TAA), is found in normal testis and on the surface of various tumor cell types."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C3899996", "l": "Autologous MAGE-A3-specific HLA-A*01-Restricted T Cell Receptor Gene Engineered Lymphocytes", "d": []}, {"i": "NCIT:C116711", "l": "Autologous MAGE-A3-specific HLA-A*01-Restricted T Cell Receptor Gene Engineered Lymphocytes", "d": ["Human autologous T-lymphocytes transduced with a retroviral vector encoding a T-cell receptor (TCR) specific for the human leukocyte antigen (HLA)-A*01-restricted, human melanoma-associated antigen A3 (MAGE-A3), with potential antineoplastic activity. Peripheral blood mononuclear cells (PBMCs) are isolated from a patient, transduced with an anti-MAGE-A3-HLA-A*01 restricted TCR, expanded ex vivo, and reintroduced into the HLA-A*01-positive patient. Then, the autologous MAGE-A3-specific, HLA-A*01-restricted TCR gene engineered lymphocytes bind to tumor cells expressing the MAGE-A3 antigen, which may increase cell death and halt the growth of MAGE-A3-expressing cancer cells. The tumor-associated antigen MAGE-A3 is overexpressed by a variety of cancer cell types."]}]}
{"type": "biolink:Cell", "ic": "89.347505587204751", "identifiers": [{"i": "CL:0000683", "l": "ependymoglial cell", "d": ["A cell that transports hormones from neurosecretory cells. This nerve cell is characterized by bipolar shape and endfeet that contact a basal lamina around blood vessels, and/or the pia mater or vitreous body of the eye and additionally contact the ventricular surface or sub-retinal space."]}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "CL:0002240", "l": "marrow fibroblast", "d": ["A fibroblast in the bone marrow."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0000257", "l": "Eumycetozoan cell", "d": []}]}
{"type": "biolink:Cell", "ic": "81.247621244257502", "identifiers": [{"i": "CL:0002010", "l": "pre-conventional dendritic cell", "d": ["A lin-negative, MHC-II-negative, CD11c-positive, FLT3-positive cell with intermediate expression of SIRP-alpha."]}]}
{"type": "biolink:Cell", "ic": "90.82444074280258", "identifiers": [{"i": "CL:0002669", "l": "type 3 otic fibrocyte", "d": ["An otic fibrocyte that lines the otic capsule."]}]}
{"type": "biolink:Cell", "ic": "85.457082654197222", "identifiers": [{"i": "UMLS:C0333735", "l": "Gemistocyte", "d": []}, {"i": "NCIT:C37132", "l": "Gemistocytic Neoplastic Astrocyte", "d": ["A pathologic astrocyte in which the cell body swells and contains glial filaments and an eccentric nucleus; seen particularly in demyelinating and neoplastic conditions."]}, {"i": "SNOMEDCT:55319008", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4505326", "l": "Dendritic Epithelial T Cells", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5186810", "l": "Metamyelocytes | Fetus | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5159882", "l": "Circulating tumor cells.prostate | Blood | Chemistry - non-challenge", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0882846", "l": "Cell positive for CD33 antigen", "d": []}, {"i": "SNOMEDCT:116825007", "d": []}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "UMLS:C1513969", "l": "Neoplastic Fusiform Cell", "d": []}, {"i": "NCIT:C36963", "l": "Neoplastic Fusiform Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:1000304", "l": "fibroblast of connective tissue of nonglandular part of prostate", "d": ["A fibroblast that is part of the connective tissue of nonglandular part of prostate."]}]}
{"type": "biolink:Cell", "ic": "88.140761698499901", "identifiers": [{"i": "CL:0002083", "l": "type I cell of adrenal medulla", "d": ["A chromaffin cell of the adrenal medulla that produces norepinephrine."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4323914", "l": "Set of cranial neural crest cells", "d": []}]}
{"type": "biolink:Cell", "ic": "73.847638787057321", "identifiers": [{"i": "CL:0002573", "l": "Schwann cell", "d": ["A glial cell that myelinates or ensheathes axons in the peripheral nervous system."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002479", "l": "F4/80-positive adipose macrophage", "d": ["An adipose macrophage that does not express MHC-II but is F4/80-positive."]}]}
{"type": "biolink:Cell", "ic": "92.728541327098611", "identifiers": [{"i": "UMLS:C1518243", "l": "Malignant Small Undifferentiated Cell", "d": []}, {"i": "NCIT:C36944", "l": "Malignant Small Undifferentiated Cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2362091", "l": "100 platelets", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1511280", "l": "Bowenoid Cell", "d": []}, {"i": "NCIT:C36755", "l": "Bowenoid Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "89.347505587204751", "identifiers": [{"i": "CL:0002492", "l": "strial marginal cell", "d": ["A polarized columnar cell that covesr the lateral surface of the cochlear duct, secretes potassium ions and forms a continuous sheet in contact with the endolymph; marginal cells form extensive interdigitations with the basal and intermediate cells in the normal adult stria."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2924223", "l": "Cells.CD13+CD34+", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0000534", "l": "primary interneuron (sensu Teleostei)", "d": ["A primary neuron (sensu Teleostei) that is neither a sensory neuron or a motor neuron."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5170955", "l": "Leukocytes other | Pericardial fluid | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "CL:0000505", "l": "substance P secreting cell", "d": ["A peptide hormone secreting cell that secretes substance P."]}]}
{"type": "biolink:Cell", "ic": "61.49789709104158", "identifiers": [{"i": "UMLS:C1517808", "l": "Leukemic Lymphocyte", "d": []}, {"i": "NCIT:C41073", "l": "Leukemic Lymphocyte", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002414", "l": "immature Vgamma1.1-positive, Vdelta6.3-negative thymocyte", "d": ["A Vgamma1.1-positive, Vdelta6.3-negative thymocyte that is CD24-positive."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5171674", "l": "Lymphocytes clefted | Blood or Tissue | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0000901", "l": "Tr1 cell", "d": ["CD4-positive alpha-beta T cell with regulatory function that produces IL-10."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4740205", "l": "Cells.TACI", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0003013", "l": "G10 retinal ganglion cell", "d": ["A mono-stratified retinal ganglion cell that has a large dendritic field, a medium dendritic arbor, and a long secondary dendrite shaft with post synaptic terminals in sublaminar layer S4."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2338888", "l": "Paneth cell of epithelium of small intestine", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002295", "l": "type-6 epithelial cell of thymus", "d": ["A thymic epithelial cell that has an eccentric, round, or irregularly shaped hetero or euchromatic nucleus. The hallmark of this cell type is the presence of vacuoles, which are clustered in one area of the cytoplasm in the vicinity of the nucleus. The vacuoles are small and acquire a grape-like form, occasionally showing delicate internal microvillous projections."]}]}
{"type": "biolink:Cell", "ic": "75.42073205405498", "identifiers": [{"i": "UMLS:C1711301", "l": "Malignant Oval Endothelial Cell", "d": []}, {"i": "NCIT:C53413", "l": "Malignant Oval Endothelial Cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157499", "l": "CD34+CD117+ blasts | XXX | Cell markers", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C4086006", "l": "Autologous Cytotoxic T-lymphocytes Induced with MUC1 Peptide-pulsed Dendritic Cells", "d": []}, {"i": "NCIT:C124998", "l": "Autologous Cytotoxic T-lymphocytes Induced with MUC1 Peptide-pulsed Dendritic Cells", "d": ["A preparation of autologous cytotoxic T-lymphocytes (CTL), specifically reactive to the tumor-associated antigen (TAA) mucin-1 (MUC1), with potential antineoplastic activity. Peripheral blood mononuclear cells (PBMCs) are collected from the patient with MUC1-positive tumors and are exposed ex vivo to dendritic cells (DCs) that are pulsed with a MUC1 peptide to generate MUC1-specific CTLs, which are subsequently expanded in vitro. Upon re-infusion of autologous CTLs induced with MUC1 peptide-pulsed DCs to the patient, the CTLs target and lyse the MUC1-expressing tumor cells. This inhibits tumor cell proliferation. MUC1 is expressed by a variety of tumor cell types."]}]}
{"type": "biolink:Cell", "ic": "89.347505587204751", "identifiers": [{"i": "CL:0000979", "l": "IgG memory B cell", "d": ["An IgG memory B cell is a class switched memory B cell that is class switched and expresses IgG on the cell surface."]}]}
{"type": "biolink:Cell", "ic": "92.728541327098611", "identifiers": [{"i": "CL:2000034", "l": "anterior lateral line neuromast hair cell", "d": ["Any neuromast hair cell that is part of a anterior lateral line."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5177777", "l": "Polymorphonuclear cells | Blood | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "ic": "89.347505587204751", "identifiers": [{"i": "UMLS:C0221266", "l": "Dacryocyte (cell)", "d": []}, {"i": "NCIT:C36726", "l": "Tear-Drop Red Blood Cell", "d": []}, {"i": "SNOMEDCT:47787007", "d": []}]}
{"type": "biolink:Cell", "ic": "68.25778018697109", "identifiers": [{"i": "UMLS:C1514023", "l": "Neoplastic Meningothelial Cell", "d": []}, {"i": "NCIT:C37155", "l": "Neoplastic Meningothelial Cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1440411", "l": "Cells.t(4;11)(q21.3;q23)(AFF1,MLL)", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1440304", "l": "Cells.CD4+CD69+", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:4030021", "l": "kidney connecting tubule beta-intercalated cell", "d": ["A renal beta-intercalated cell that is part of the renal connecting tubule."]}]}
{"type": "biolink:Cell", "ic": "70.595126831462238", "identifiers": [{"i": "UMLS:C1513935", "l": "Neoplastic Cell with Eosinophilic Cytoplasm", "d": []}, {"i": "NCIT:C37105", "l": "Neoplastic Cell with Eosinophilic Cytoplasm", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0229636", "l": "Neutrophilic promyelocyte", "d": []}, {"i": "SNOMEDCT:34254002", "d": []}]}
{"type": "biolink:Cell", "ic": "80.511444690059548", "identifiers": [{"i": "CL:0002045", "l": "fraction A pre-pro B cell", "d": ["A pro-B cell that is CD45R/B220-positive, CD43-positive, HSA-low, BP-1-negative and Ly6c-negative. This cell type is also described as being lin-negative, AA4-positive, Kit-positive, IL7Ra-positive and CD45R-positive."]}]}
{"type": "biolink:Cell", "ic": "64.6720795298599", "identifiers": [{"i": "CL:0009004", "l": "retinal cell", "d": ["Any cell in the retina, the innermost layer or coating at the back of the eyeball, which is sensitive to light and in which the optic nerve terminates."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1440293", "l": "Cells.CD31", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1267965", "l": "Lymphocyte positive for CD71 antigen", "d": []}, {"i": "SNOMEDCT:116846003", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4722559", "l": "NKCARCD19", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0000208", "l": "pH receptor cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5177476", "l": "Plasma cells/100 leukocytes | Pleural fluid | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:1000489", "l": "reticular cell of splenic cord", "d": ["A reticular cell that is part of the splenic cord."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "MESH:D016175", "l": "B-Lymphocyte Subsets", "d": []}]}
{"type": "biolink:Cell", "ic": "89.347505587204751", "identifiers": [{"i": "UMLS:C1515186", "l": "Gamma/Delta T-Lymphocyte", "d": []}, {"i": "NCIT:C39585", "l": "Gamma/Delta T-Lymphocyte", "d": ["A resting, mature T cell that probably plays a primary role in suppressor/cytotoxic phenomena."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:1000277", "l": "smooth muscle fiber of jejunum", "d": ["A smooth muscle cell that is part of the jejunum."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1267855", "l": "Lymphocyte positive for both CD8 antigen and CD28 antigen", "d": []}, {"i": "SNOMEDCT:117540006", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C4727117", "l": "Hematopoietic Immune Cell", "d": []}, {"i": "NCIT:C153245", "l": "Hematopoietic Immune Cell", "d": ["A population of cells involved in the formation of blood cells and in host defense."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C3852949", "l": "V1-Derived Interneurons", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0004219", "l": "A2 amacrine cell", "d": ["A bistratifed retinal amacrine cell with a small dendritic field, dendrite stratification in S1-S2, and a second dendrite stratification in S5. This cell type releases the neurotransmitter glycine."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5220604", "l": "Oval fat bodies (globules)|Urine/Urine sed", "d": []}]}
{"type": "biolink:Cell", "ic": "77.488267285704651", "identifiers": [{"i": "CL:0000596", "l": "sexual spore", "d": ["A spore formed following meiosis. Sometimes following meiosis, prospores may undergo one or more rounds of mitosis before they are fully mature."]}]}
{"type": "biolink:Cell", "ic": "92.728541327098611", "identifiers": [{"i": "CL:2000073", "l": "migratory cardiac neural crest cell", "d": ["Any migratory neural crest cell that is part of a cardiac neural crest."]}]}
{"type": "biolink:Cell", "ic": "86.236661114203869", "identifiers": [{"i": "CL:0000751", "l": "rod bipolar cell", "d": ["A bipolar neuron found in the retina that is synapsed by rod photoreceptor cells but not by cone photoreceptor cells.  These neurons depolarize in response to light."]}]}
{"type": "biolink:Cell", "ic": "63.481265292451688", "identifiers": [{"i": "UMLS:C1708878", "l": "Malignant Germ Cell", "d": []}, {"i": "NCIT:C54110", "l": "Malignant Germ Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "82.532694649739099", "identifiers": [{"i": "CL:0002180", "l": "mucous cell of stomach", "d": ["A mucous cell in the epithelium of the stomach."]}]}
{"type": "biolink:Cell", "ic": "69.721054312086878", "identifiers": [{"i": "UMLS:C0225335", "l": "Mesothelial cell", "d": []}, {"i": "NCIT:C33104", "l": "Mesothelial Cell", "d": ["A flat cell of mesenchymal origin that forms the superficial layer of the serosal membranes lining the body cavities of the abdomen and thorax."]}, {"i": "SNOMEDCT:58966000", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2326121", "l": "Golgi neuron", "d": []}]}
{"type": "biolink:Cell", "ic": "92.728541327098611", "identifiers": [{"i": "CL:0000141", "l": "cementocyte", "d": ["An osteocytelike cell with numerous processes, trapped in a lacuna in the cement of the tooth."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0598088", "l": "continuous cell line", "d": []}]}
{"type": "biolink:Cell", "ic": "74.659114980698789", "identifiers": [{"i": "UMLS:C1516945", "l": "Epithelioid Endothelial Cell", "d": []}, {"i": "NCIT:C37093", "l": "Epithelioid Endothelial Cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0882795", "l": "Cells.CD15", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0000428", "l": "yolk cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4722614", "l": "Theralux-ATIR", "d": []}]}
{"type": "biolink:Cell", "ic": "92.728541327098611", "identifiers": [{"i": "CL:0000865", "l": "gastrointestinal tract (lamina propria) macrophage", "d": ["A gut-associated lymphoid tissue macrophage found in lamina propria of the gut."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C3656576", "l": "Cells.CD158b", "d": []}]}
{"type": "biolink:Cell", "ic": "92.728541327098611", "identifiers": [{"i": "CL:0000726", "l": "chlamydospore", "d": ["An asexual 1-celled spore (primarily for perennation, not dissemination). Originates endogenously and singly within part of a pre-existing cell by the contraction of the protoplast. Possesses an inner secondary and often thickened hyaline or brown wall, usually impregnated with hydrophobic material."]}]}
{"type": "biolink:Cell", "ic": "49.560329272764719", "identifiers": [{"i": "CL:0000134", "l": "mesenchymal stem cell", "d": ["A connective tissue cell that normally gives rise to other cells that are organized as three-dimensional masses. In humans, this cell type is CD73-positive, CD90-positive, CD105-positive, CD45-negative, CD34-negative, and MHCII-negative. They may further differentiate into osteoblasts, adipocytes, myocytes, neurons, or chondroblasts in vitro. Originally described as residing in the bone marrow, this cell type is now known to reside in many, if not all, adult organs."]}]}
{"type": "biolink:Cell", "ic": "86.236661114203869", "identifiers": [{"i": "CL:0000570", "l": "parafollicular cell", "d": ["A neuroepithelial cells that occurs singly or in small groups, close to the outer follicular borders but within the follicular basement membrane of the thyroid. Expresses a form of the neural cell adhesion molecule (N-CAM) on their surface. Secretes calcitonin, 5-hydroxytryptamine and dopamine."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C4763382", "l": "Autologous Anti-NY-ESO-1/LAGE-1 TCR-transduced c259 T Lymphocytes GSK3377794", "d": []}, {"i": "NCIT:C121379", "l": "Letetresgene Autoleucel", "d": ["Human autologous T-lymphocytes transduced with a lentiviral vector encoding a T-cell receptor (TCR) specific for the cancer-testis antigens (CTAs) NY-ESO-1 and L antigen family member 1 (LAGE-1; Cancer/Testis Antigen 2; CTAG2; CT2), with potential antineoplastic activity. Following leukapheresis, isolation of lymphocytes, expansion ex vivo, transduction, and reintroduction into the patient, letetresgene autoleucel specifically target and bind to NY-ESO-1/LAGE-1-overexpressing tumor cells. This may result in a cytotoxic T-lymphocyte (CTL)-mediated elimination of NY-ESO-1/LAGE-1-positive cancer cells. NY-ESO-1 and LAGE-1, members of the cancer-testis antigen (CTA) family, are overexpressed on the surface of various tumor cell types."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0230519", "l": "Mitotic cell in prophase", "d": []}, {"i": "SNOMEDCT:13056009", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5417988", "l": "Autologous Tumor Infiltrating Lymphocytes LN-145-S1", "d": []}, {"i": "NCIT:C173508", "l": "Autologous Tumor Infiltrating Lymphocytes LN-145-S1", "d": ["A proprietary preparation of autologous tumor infiltrating lymphocytes (TILs), with potential immunomodulating and antineoplastic activities. The autologous TILs are isolated from an autologous tumor sample and expanded ex vivo in the presence of interleukin-2 (IL-2). Upon infusion of the autologous TILs LN-145-S1 back into the patient, the cells specifically recognize, target and kill the patient's tumor cells."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C3899314", "l": "EGFRvIII-specific CAR-transduced Autologous T Lymphocytes", "d": []}, {"i": "NCIT:C117727", "l": "EGFRvIII-specific CAR-transduced Autologous T Lymphocytes", "d": ["Autologous human T-lymphocytes transduced with a retroviral vector encoding an anti-epidermal growth factor receptor variant III (EGFRvIII) mutant chimeric T-cell receptor (chimeric antigen receptor or CAR) gene, with potential immunostimulatory and antineoplastic activities. Upon administration, the EGFRvIII-specific CAR-transduced autologous T-lymphocytes bind to the EGFRvIII antigen on tumor cell surfaces; subsequently, EGFRvIII-expressing tumor cells may be lysed. EGFRvIII, an in-frame deletion of exons 2-7 in the EGFR gene, is overexpressed by a variety of cancer cell types but absent in normal, healthy cells. It plays a key role in tumor cell proliferation, tumor angiogenesis and resistance to both radio- and chemotherapy."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0000343", "l": "visual pigment cell (sensu Vertebrata)", "d": ["A pigment cell that is capable of detecting light stimulus that is involved in visual perception."]}]}
{"type": "biolink:Cell", "ic": "90.82444074280258", "identifiers": [{"i": "UMLS:C0333851", "l": "Sezary cell", "d": []}, {"i": "NCIT:C36722", "l": "Sezary Cell", "d": ["A large, neoplastic T-lymphocyte with an irregularly shaped nuclei and scant cytoplasm that is associated with Sezary Syndrome."]}, {"i": "SNOMEDCT:45614000", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0677626", "l": "hepatoma cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5382906", "l": "HLA-B35 CMV specific CD8 cells | Blood | Cell markers", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5575456", "l": "Autologous Anti-glypican-3 CAR-IL-15-iC9-expressing T-lymphocytes", "d": []}, {"i": "NCIT:C185176", "l": "Autologous Anti-glypican-3 CAR-IL-15-iC9-expressing T-lymphocytes", "d": ["A preparation of T-lymphocytes that have been genetically modified to express a chimeric antigen receptor (CAR) specific for glypican-3 (GPC3) and express interleukin-15 (IL-15) and the suicide gene, inducible caspase 9 (iCasp9 or iC9), with potential immunostimulating and antineoplastic activities. Upon administration, anti-GPC3-CAR-IL-15-iC9-expressing T-lymphocytes specifically target and bind to GPC3-expressing tumor cells, resulting in tumor cell lysis. GPC3, a heparan sulfate proteoglycan and a member of the glypican family, is overexpressed on certain tumor cell types while minimally expressed on normal, healthy cells; GPC3 plays an important role in cellular proliferation and differentiation. IL-15 is a pro-survival cytokine that potentiates, in addition to promoting T-cell proliferation and persistence, the immune response against tumor cells. The iCasp9 safety switch consists of a full-length caspase 9, including its caspase recruitment domain, linked to a human FK506 drug-binding domain with an F36V mutation (FKBP12-F36V). If the administered CAR T-cells lead to unacceptable side effects, the chemical homodimerizer AP1903 can be administered. AP1903 binds to the FKBP12-F36V drug-binding domain, activates caspase 9 and results in apoptosis of the administered CAR T-cells."]}]}
{"type": "biolink:Cell", "ic": "72.170119586754993", "identifiers": [{"i": "UMLS:C1518311", "l": "Nevus cell", "d": []}, {"i": "NCIT:C25585", "l": "Nevus Cell", "d": ["A neoplastic cutaneous melanocyte that characterizes benign and atypical cutaneous neoplastic lesions called nevi."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5421268", "l": "Autologous Nectin-4/FAP-targeted CAR-T Cells", "d": []}, {"i": "NCIT:C172386", "l": "Autologous Nectin-4/FAP-targeted CAR-T Cells", "d": ["A preparation of autologous T-lymphocytes engineered to express a chimeric antigen receptor (CAR) specific for the tumor-associated antigen (TAA) nectin-4 and cell surface protein fibroblast activation protein (FAP), and additionally an inducible expression cassette encoding transgenic interleukin (IL) 7 (IL-7) or 12 (IL-12), with potential immunostimulating and antineoplastic activities. Upon intratumoral administration, the autologous nectin-4/FAP-targeted CAR-T cells target and bind to nectin-4-expressing tumor cells and FAP-expressing cancer associated fibroblasts (CAFs). This results in a cytotoxic T-lymphocyte (CTL) response against nectin-4-expressing tumor cells and FAP-expressing CAFs, leading to cell lysis of these cells. Upon the binding to nectin-4 and FAP and the activation of the CAR-T cells, cytokine IL-7 or IL-12 is also released. This further augments the immune responses against the tumor cells, which may include the attack of nectin-4-negative tumor cells by tumor necrosis factor alpha (TNFa). Nectin-4, a TAA belonging to the nectin family, is overexpressed in a variety of cancers, including breast, bladder, lung and pancreatic cancer. FAP, a cell surface glycoprotein, is overexpressed on CAFs but minimally expressed on normal, healthy cells."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C4525866", "l": "Autologous MAGE-A3/A6-specific TCR Gene-engineered Lymphocytes KITE-718", "d": []}, {"i": "NCIT:C135534", "l": "Autologous MAGE-A3/A6-specific TCR Gene-engineered Lymphocytes KITE-718", "d": ["Human autologous T-lymphocytes genetically modified to express a T-cell receptor (TCR) that specifically targets human melanoma-associated antigen A3 (MAGE-A3) and MAGE-A6 (MAGEA3/A6; MAGE-A3/A6), with potential antineoplastic activity. Peripheral blood mononuclear cells (PBMCs) are isolated from a patient, transduced with a gene expressing a TCR specific for the MAGE-A3/A6 antigens, expanded ex vivo, and reintroduced into the patient. Then, the autologous MAGE-A3/A6-specific TCR gene engineered lymphocytes KITE-718 target and bind to tumor cells expressing the MAGE-A3 and/or MAGE-A6 antigens. This halts the growth of and kills MAGE-A3/A6-expressing cancer cells. The tumor-associated antigens MAGE-A3 and MAGE-A6 are overexpressed on a variety of tumor cell types."]}]}
{"type": "biolink:Cell", "ic": "87.120474278337809", "identifiers": [{"i": "CL:0000916", "l": "dendritic epidermal T cell", "d": ["A mature gamma-delta T cell located in the epidermis that regulates wound healing."]}]}
{"type": "biolink:Cell", "ic": "87.120474278337809", "identifiers": [{"i": "CL:0000829", "l": "basophilic myeloblast", "d": ["A myeloblast committed to the basophil lineage."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0000950", "l": "IgE plasmablast", "d": ["A plasmablast that secretes IgE."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1179113", "l": "Supporting cell of olfactory epithelium", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4038494", "l": "Cells.aneuploid.S phase population 2", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002205", "l": "brush cell of lobular bronchiole", "d": ["A brush cell found in the epithelium of lobular bronchiole."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C4733642", "l": "Autologous Anti-HLA-A*0201/AFP CAR T-cells ET1402L1", "d": []}, {"i": "NCIT:C155884", "l": "Autologous Anti-HLA-A*0201/AFP CAR T-cells ET1402L1", "d": ["A preparation of autologous T-lymphocytes that have been transduced with a lentiviral vector encoding a chimeric antigen receptor (CAR) containing a single chain variable fragment (scFv) derived from a human monoclonal antibody specific for an immunogenic human tumor-associated antigen (TAA) alpha-fetoprotein (AFP) epitope, AFP158-166, complexed with human leukocyte antigen (HLA)-A*02:01 (HLA-A*0201/AFP), fused to the co-stimulatory domains of CD28 and CD3zeta, with potential immunostimulating and antineoplastic activities. Upon administration, the autologous anti-HLA-A*0201/AFP CAR T-cells ET1402L1 specifically recognize and selectively bind to the AFP158-166 peptide presented by HLA-A*0201. Upon binding to the AFP-MHC complex, the T-cells release cytokines and induce selective toxicity in HLA-A*0201/AFP-positive tumor cells. AFP, an intracellularly expressed fetal glycoprotein rarely expressed in adult tissues, is overexpressed in certain tumors of endodermal origin and plays a key role in tumor cell proliferation and survival. AFP is processed into peptides and presented by class I major histocompatibility complexes (MHCs) on the surface of tumor cells."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0883475", "l": "Cells.CD5+CD25+", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1512137", "l": "ESO-1 Reactive Autologous Peripheral Blood Lymphocyte", "d": []}, {"i": "NCIT:C38119", "l": "ESO-1 Reactive Autologous Peripheral Blood Lymphocyte", "d": ["Human peripheral blood lymphocytes (PBL) isolated from a patient, exposed to the tumor-associated protein ESO-1 in vitro, and then transferred back to the same patient to target tumor cells expressing ESO-1. ESO-1 is a human self-antigen expressed by melanomas. The ESO-1 gene encodes several MHC class I- and MHC class II-restricted epitopes that may activate cytotoxic T-cell-mediated tumor destruction. (NCI04)"]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0221282", "l": "Schistocyte", "d": []}, {"i": "SNOMEDCT:70310009", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5216310", "l": "Polymorphonuclear cells|NCnc|Pt|Body fld", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002626", "l": "immature astrocyte", "d": ["An immature astrocyte."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002380", "l": "oospore", "d": ["An asexual spore formed by Oomycetes; formed upon fertilization of an oosphere."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1631818", "l": "Cells.CD20+CD117+", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5216289", "l": "Neutrophils.segmented|NCnc|Pt|Body fld", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1979642", "l": "Blast cell positive for CD25 antigen", "d": []}, {"i": "SNOMEDCT:724263000", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C0085080", "l": "Chinese Hamster Ovary Cell", "d": []}, {"i": "NCIT:C17421", "l": "CHO Cells", "d": ["The parental CHO cell line initiated from a biopsy of an ovary of an adult Chinese hamster."]}, {"i": "MESH:D016466", "l": "CHO Cells", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1511007", "l": "BG02", "d": []}, {"i": "NCIT:C20234", "l": "BG02", "d": ["Provider: BresaGen, Inc., Athens, GA. Information from provider and not independently verified by NIH: Cells are positive for cell markers SSEA-3, SSEA-4, TRA 1-60, TRA 1-81, Oct-4, and alkaline phosphatase; Cells are negative for the cell marker SSEA1. This cell line meets the criteria for the use of human embryonic stem cells by federally funded researchers."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1511440", "l": "CH02", "d": []}, {"i": "NCIT:C20286", "l": "CH02", "d": ["Provider: Pochon CHA University, Seoul, Korea. No information from provider. This cell line meets the criteria for the use of human embryonic stem cells by federally funded researchers."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C0333842", "l": "Niemann-Pick cell", "d": []}, {"i": "NCIT:C36844", "l": "Niemann-Pick Cell", "d": []}, {"i": "SNOMEDCT:9240003", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002623", "l": "acinar cell of salivary gland", "d": ["An acinar cell of salivary gland."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0333824", "l": "Pancake cell", "d": []}, {"i": "SNOMEDCT:28789003", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C0035286", "l": "Reticulocytes", "d": []}, {"i": "NCIT:C12528", "l": "Reticulocyte", "d": ["Immature erythrocytes that have just undergone extrusion of their cell nucleus. They still contain some organelles that gradually decrease in number as the cells mature."]}, {"i": "MESH:D012156", "l": "Reticulocytes", "d": []}, {"i": "SNOMEDCT:52802009", "d": []}]}
{"type": "biolink:Cell", "ic": "88.140761698499901", "identifiers": [{"i": "CL:0001009", "l": "immature dermal dendritic cell", "d": ["Immature dermal dendritic cell is a dermal dendritic cell that is CD80-low, CD86-low, and MHCII-low."]}]}
{"type": "biolink:Cell", "ic": "89.347505587204751", "identifiers": [{"i": "CL:0002172", "l": "interdental cell of cochlea", "d": ["A long, spindle-shaped supporting cells arranged in parallel rows that secretes components of the tectorial membrane and potassium ions into the endolymph."]}]}
{"type": "biolink:Cell", "ic": "71.423552501508112", "identifiers": [{"i": "UMLS:C1522078", "l": "Abnormal Granulocyte", "d": []}, {"i": "NCIT:C37050", "l": "Abnormal Granulocyte", "d": []}]}
{"type": "biolink:Cell", "ic": "57.518338488785304", "identifiers": [{"i": "CL:0000457", "l": "biogenic amine secreting cell", "d": []}]}
{"type": "biolink:Cell", "ic": "43.980130757466291", "identifiers": [{"i": "CL:0000151", "l": "secretory cell", "d": ["A cell that specializes in controlled release of one or more substances."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5418021", "l": "Anti-GPC3-CAR T-lymphocytes TAK-102", "d": []}, {"i": "NCIT:C173713", "l": "Anti-GPC3-CAR T-lymphocytes TAK-102", "d": ["A preparation of T-lymphocytes that have been genetically modified to express a chimeric antigen receptor (CAR) specific for glypican-3 (GPC3), with potential immunostimulating and antineoplastic activities. Upon administration, anti-GPC3-CAR T-lymphocytes TAK-102 specifically targets and binds to GPC3-expressing tumor cells, resulting in tumor cell lysis. GPC3, a heparan sulfate proteoglycan and a member of the glypican family, is overexpressed on certain tumor cell types while minimally expressed on normal, healthy cells; GPC3 plays an important role in cellular proliferation and differentiation."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0000105", "l": "pseudounipolar neuron", "d": ["Neuron with two neurites that are fused grossly when they protrude from the soma and bifurcate a short distance from the soma."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C3640056", "l": "CD19CAR-CD3zeta-4-1BB-expressing Allogeneic T-lymphocyte Cells", "d": []}, {"i": "NCIT:C101258", "l": "CD19CAR-CD3zeta-4-1BB-expressing Allogeneic T-lymphocyte Cells", "d": ["Allogeneic T-lymphocytes transduced with a modified lentiviral vector expressing a chimeric antigen receptor (CAR) consisting of an anti-CD19 scFv (single chain variable fragment) and the zeta chain of the TCR/CD3 complex (CD3-zeta), coupled to the signaling domain of 4-1BB (CD137), with potential immunomodulating and antineoplastic activities. Upon transfusion, CD19CAR-CD3zeta-4-1BB-expressing allogeneic T-lymphocyte cells direct the T-lymphocytes to CD19-expressing tumor cells, thereby inducing a selective toxicity in CD19-expressing tumor cells. The 4-1BB co-stimulatory molecule signaling domain enhances activation and signaling after recognition of CD19 and the inclusion of this signaling domain may increase the antitumor activity compared to the inclusion of the CD3-zeta chain alone. CD19 antigen is a B-cell specific cell surface antigen expressed in all B-cell lineage malignancies."]}]}
{"type": "biolink:Cell", "ic": "82.532694649739099", "identifiers": [{"i": "CL:0001026", "l": "CD34-positive, CD38-positive common myeloid progenitor", "d": ["A common myeloid progenitor that is CD34-positive, CD38-positive, IL3ra-low, CD10-negative, CD7-negative, CD45RA-negative, and IL-5Ralpha-negative."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1267820", "l": "Lymphocyte positive for both CD3 antigen and CD38 antigen", "d": []}, {"i": "SNOMEDCT:117521000", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5216208", "l": "Erythrocytes.nucleated|NCnc|Pt|CSF", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1519712", "l": "Type III Epithelial Receptor Cell", "d": []}, {"i": "NCIT:C13149", "l": "Type III Epithelial Receptor Cell", "d": ["A light cell found in taste buds, characterized by afferent synaptic specializations to intragemminal nerve endings including increased density of the plasma membrane along the nerve and aggregations of synaptic vesicles, and by the presence of cored vesicles of 80-150 nm in diameter. The core is dense and the cell is immunoreactive for 5-hydroxytryptamine, neural cell adhesion molecule, and PGP 9.5."]}]}
{"type": "biolink:Cell", "ic": "73.597844352697123", "identifiers": [{"i": "UMLS:C0225356", "l": "Myoepithelial cell", "d": []}, {"i": "NCIT:C33152", "l": "Myoepithelial Cell", "d": ["A contractile cell found between the secretory cells and basement membrane of exocrine glands. Each myoepithelial cell has long cytoplasmic processes that wrap around a secretory unit. The contraction of the myoepithelial processes forces the secretory product from the secretory unit into its duct."]}, {"i": "SNOMEDCT:71343003", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5177617", "l": "Platelets | Blood cord | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4740203", "l": "Cells.CD24-FLAER-", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5148826", "l": "Reticulocytes.medium fluorescence", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1440235", "l": "Cell positive for CD103 antigen", "d": []}, {"i": "SNOMEDCT:725327006", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1516963", "l": "Glandular cell of esophagus", "d": []}, {"i": "NCIT:C32537", "l": "Esophageal Glandular Cell", "d": ["An epithelial cell that covers the lower third of the esophageal lumen. It is also found in the submucosal glands of the esophagus."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1514046", "l": "Neoplastic Neuroendocrine Polygonal Cell with Cytoplasmic Eosinophilic Globules", "d": []}, {"i": "NCIT:C36934", "l": "Neoplastic Neuroendocrine Polygonal Cell with Cytoplasmic Eosinophilic Globules", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0001005", "l": "mature CD8_alpha-positive CD11b-negative dendritic cell", "d": ["Mature CD8_alpha-positive CD11b-negative dendritic cell is a CD8_alpha-positive CD11b-negative dendritic cell that is CD80-high, CD86-high, MHCII-high and is CD83-positive."]}]}
{"type": "biolink:Cell", "ic": "90.82444074280258", "identifiers": [{"i": "CL:0007006", "l": "chordamesodermal cell", "d": ["Mesodermal cell that is axially located and gives rise to the cells of the notochord."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1979637", "l": "Blasts.CD16", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C4761323", "l": "TCR alpha/beta/CD19-depleted Allogeneic Hematopoietic Progenitor Cells", "d": []}, {"i": "NCIT:C157370", "l": "TCR alpha/beta/CD19-depleted Allogeneic Hematopoietic Progenitor Cells", "d": ["A preparation of hematopoietic progenitor cells (HPCs) from a haploidentical donor that have been depleted of T-cell receptor (TCR) alpha and beta (TCRa/b+) as well as CD19-positive (CD19+) cells, that can potentially be used for immune reconstitution purposes. The TCR alpha/beta/CD19-depleted HPCs contain high amounts of natural killer (NK) cells, gamma/delta T-cells, CD34+ stem cells, monocytes, and dendritic cells (DCs), while devoid of alpha/beta T-cells and CD19-positive B-cells. The TCR alpha/beta/CD19-depleted HPCs are used for allogeneic hematopoietic cell transplantation (HCT) and may allow for rapid and sustained engraftment, rapid immune reconstitution, and may prevent or reduce graft-versus-host disease (GvHD)."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5163547", "l": "Epithelial cells.ciliated | Bronchoalveolar lavage | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "ic": "74.107231545810777", "identifiers": [{"i": "UMLS:C1708920", "l": "Malignant Syncytiotrophoblastic Giant Cell", "d": []}, {"i": "NCIT:C54119", "l": "Malignant Syncytiotrophoblastic Giant Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002621", "l": "gingival epithelial cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5175004", "l": "Normoblasts | Blood | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0524978", "l": "Intestinal Secretin Cells", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5170926", "l": "Leukocytes | Dialysis fluid | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "ic": "81.247621244257502", "identifiers": [{"i": "CL:0002098", "l": "regular cardiac myocyte", "d": ["A cardiac myocyte that is connected to other cardiac myocytes by transverse intercalated discs (GO:0014704) at a regular interval."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0945933", "l": "CD45+ cell", "d": []}, {"i": "SNOMEDCT:732272000", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:4023116", "l": "type 2 spiral ganglion neuron", "d": ["A spiral ganglion neuron that innervates outer hair cells. Type 1 spiral ganglion neurons are unmyelinated and unipolar."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2323694", "l": "Dense-core granulated cell of epithelium of trachea", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5446546", "l": "Autologous Anti-CD19 CAR-4-1BB-CD3zeta-expressing T-cells CNCT19", "d": []}, {"i": "NCIT:C175465", "l": "Autologous Anti-CD19 CAR-4-1BB-CD3zeta-expressing T-cells CNCT19", "d": ["A preparation of autologous T-lymphocytes that are engineered to express a chimeric antigen receptor (CAR) composed of an anti-cluster of differentiation 19 (CD19) single chain variable fragment (scFv) linked to the intracellular signaling domains of 4-1BB (CD137) and the zeta chain of the TCR/CD3 complex (TCRzeta; CD247; CD3zeta), with potential immunomodulating and antineoplastic activities. Upon administration, the autologous anti-CD19 CAR-4-1BB-CD3zeta-expressing T-cells CNCT19 target, bind to and induce selective toxicity in CD19-expressing tumor cells. CD19 antigen is a B-cell specific cell surface antigen expressed in all B-cell lineage malignancies."]}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "CL:1000380", "l": "type 1 vestibular sensory cell of epithelium of macula of saccule of membranous labyrinth", "d": ["A type I vestibular sensory cell that is part of the epithelium of macula of saccule of membranous labyrinth."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0229658", "l": "Proplasmacyte", "d": []}, {"i": "SNOMEDCT:24884008", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1979640", "l": "Blast cell positive for CD23 antigen", "d": []}, {"i": "SNOMEDCT:724265007", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1182708", "l": "Epithelial cell of stratum germinativum of esophagus", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002571", "l": "hepatic mesenchymal stem cell", "d": ["A mesenchymal stem cell of liver."]}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "UMLS:C0043544", "l": "Structure of zygote", "d": []}, {"i": "NCIT:C12601", "l": "Zygote", "d": ["The cell formed by the union of two gametes, especially a fertilized ovum before cleavage. (Online Medical Dictionary)"]}, {"i": "MESH:D015053", "l": "Zygote", "d": []}, {"i": "SNOMEDCT:57323001", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C0206190", "l": "Macrophages, Peritoneal", "d": []}, {"i": "NCIT:C12566", "l": "Peritoneal Macrophage", "d": ["A differentiated macrophage that resides in the serosal peritoneal membrane and plays an important role in the defense against peritoneal cavity infections."]}, {"i": "MESH:D017737", "l": "Macrophages, Peritoneal", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002644", "l": "endo-epithelial cell of tympanic part of viscerocranial mucosa", "d": ["An endothelial cell of viscerocranial mucosa that is part of the tympanic region of the viscerocranial mucosa."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002160", "l": "basal external epithelial cell of tympanic membrane", "d": ["A cell type found in the basal epithelial layer on the external side of the tympanic membrane. Cell type is flattened with intracellular spaces of variable dimensions."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5447599", "l": "Umbilical Cord Blood-derived CD16-expressing Natural Killer Cells AB-101", "d": []}, {"i": "NCIT:C177152", "l": "Umbilical Cord Blood-derived CD16-expressing Natural Killer Cells AB-101", "d": ["A preparation of allogeneic, off-the-shelf natural killer (NK) cells, derived from umbilical cord blood (UCB) and ex vivo-expanded, that expresses a high-affinity variant of CD16, with potential immunostimulatory and antineoplastic activities. Upon administration, UCB-derived CD16-expressing NK cells AB-101 lyse tumor cells. NK cells AB-101 also secrete pro-inflammatory cytokines, which further stimulate an anti-tumor immune response. Upon coadministration with tumor-targeting monoclonal antibodies, the Fab moiety of the antibodies bind to the tumor-associated antigens (TAAs) expressed on tumor cells and the Fc moiety of the antibodies bind to CD16 expressed on NK cells AB-101. This leads to NK cell activation, cytokine secretion and antibody-dependent cellular cytotoxicity (ADCC). CD16, also known as Fc-gamma receptor III, is normally expressed on the surface of NK cells, neutrophils, monocytes and macrophages, and plays a key role in initiating ADCC. It is often downregulated in certain cancers, thereby inhibiting the anti-tumor immune response."]}]}
{"type": "biolink:Cell", "ic": "88.140761698499901", "identifiers": [{"i": "UMLS:C1709174", "l": "Neoplastic Epithelioid Stromal Cell", "d": []}, {"i": "NCIT:C54002", "l": "Neoplastic Epithelioid Stromal Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C3831512", "l": "Anti-NY-ESO1 TCR-transduced Autologous CD62L+-derived T-Lymphocytes", "d": []}, {"i": "NCIT:C114295", "l": "Anti-NY-ESO1 TCR-transduced Autologous CD62L+-derived T-Lymphocytes", "d": ["Human autologous CD62L-positive T-lymphocytes transduced with a retroviral vector encoding a T cell receptor (TCR) specific for the cancer-testis antigen NY-ESO-1, with potential antineoplastic activity. Following leukapheresis, isolation of lymphocytes, expansion ex vivo, transduction, and reintroduction into the patient, the anti-NY-ESO1 TCR-transduced autologous CD62L+-derived T-Lymphocytes bind to NY-ESO-1-overexpressing tumor cells. This may result in cytotoxic T-lymphocyte (CTL)-mediated elimination of NY-ESO-1-positive cancer cells. NY-ESO-1, a tumor associated antigen (TAA), is found in normal testis and on the surface of various tumor cell types. CD62L, also called L-selectin, is a lymphoid homing receptor and differentiation marker and is expressed on a subset of CD8-positive T-lymphocytes; it is involved in the migration of T-lymphocytes to lymph nodes and may improve the efficacy for ex vivo-expanded T-cells following adoptive cell therapy."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5173471", "l": "Monocytes+Macrophages | Pleural fluid | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1719198", "l": "Cells.CD20+CD52+", "d": []}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "CL:0000607", "l": "ascospore", "d": ["A thick walled spore that stores and protects one or more nuclei following sexual reproduction in an Ascomycete."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0004235", "l": "AB broad diffuse-1 amacrine cell", "d": ["An amacrine cell with a medium dendritic field and post-synaptic terminals in S2 and S3. This cell type releases the neurotransmitter gamma-aminobutyric acid (GABA)."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5571671", "l": "Erythrocytes|NCnc|Pt|BAL", "d": []}]}
{"type": "biolink:Cell", "ic": "79.541110464886842", "identifiers": [{"i": "CL:0001024", "l": "CD34-positive, CD38-negative hematopoietic stem cell", "d": ["CD133-positive hematopoietic stem cell is a hematopoietic stem cell that is CD34-positive, CD90-positive, and CD133-positive."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4329802", "l": "Ex Vivo-expanded Autologous T Cells IMA101", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5216294", "l": "Neutrophils|NCnc|Pt|Periton fld", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5216272", "l": "Monocytes|NCnc|Pt|Bld", "d": []}]}
{"type": "biolink:Cell", "ic": "87.120474278337809", "identifiers": [{"i": "CL:1000742", "l": "glomerular mesangial cell", "d": ["A mesangial cell located among the glomerular capillaries in a renal corpuscle."]}]}
{"type": "biolink:Cell", "ic": "74.953330836288131", "identifiers": [{"i": "UMLS:C1519377", "l": "Neoplastic Small Lymphocyte with Clumped Chromatin", "d": []}, {"i": "NCIT:C36999", "l": "Neoplastic Small Lymphocyte with Clumped Chromatin", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:1000719", "l": "kidney inner medulla collecting duct intercalated cell", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5417979", "l": "Autologous AFP Specific T Cell Receptor Transduced T Cells C-TCR055", "d": []}, {"i": "NCIT:C173429", "l": "Autologous AFP Specific T Cell Receptor Transduced T Cells C-TCR055", "d": ["A preparation of human autologous T-lymphocytes transduced with a lentiviral vector encoding for a T-cell receptor (TCR) recognizing the human leukocyte antigen (HLA)-A*02:01 restricted human alpha-fetoprotein (AFP) 158-166 peptide (FMNKFIYEI), with potential antineoplastic activity. Upon isolation, transduction, expansion ex vivo, and reintroduction into the patient, the AFP specific TCR transduced T cells recognize and bind to AFP antigen-positive cells, which results in lysis and killing of AFP-positive cancer cells. AFP is overexpressed in a variety of cancers while its expression is restricted in normal tissues."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1440288", "l": "Cells.CD3+CD8+CD45RO+CD45RA+", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5163437", "l": "Eosinophils | Body fluid | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0684133", "l": "neure", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5178092", "l": "Prekeratocytes | Blood | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:1000278", "l": "smooth muscle fiber of ileum", "d": ["A smooth muscle cell that is part of the ileum."]}]}
{"type": "biolink:Cell", "ic": "44.148419550421615", "identifiers": [{"i": "CL:0000055", "l": "non-terminally differentiated cell", "d": ["A precursor cell with a limited number of potential fates."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0000621", "l": "fusion competent myoblast", "d": ["A myoblast that is committed to a myotube-specific program of differentiation but not yet fused. It undergoes very limited additional proliferation. After fusion, it will take on a muscle identity specified by a `muscle founder cell` (CL:0008006)."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4042878", "l": "Embryonic Germ Cells", "d": []}, {"i": "MESH:D000066473", "l": "Embryonic Germ Cells", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0229661", "l": "Myelomonoblast", "d": []}, {"i": "SNOMEDCT:88978008", "d": []}]}
{"type": "biolink:Cell", "ic": "70.595126831462238", "identifiers": [{"i": "UMLS:C1510738", "l": "Abnormal Trophoblastic Cell", "d": []}, {"i": "NCIT:C36799", "l": "Abnormal Trophoblastic Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "87.120474278337809", "identifiers": [{"i": "CL:1001602", "l": "cerebral cortex endothelial cell", "d": ["Endothelial cells forming the walls of the capillaries within the cerebral cortex."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5418366", "l": "Elivaldogene Tavalentivec", "d": []}, {"i": "NCIT:C169938", "l": "Elivaldogene Tavalentivec", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1267818", "l": "Lymphocyte positive for both CD3 antigen and CD25 antigen", "d": []}, {"i": "SNOMEDCT:116856004", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002059", "l": "CD8alpha-positive thymic conventional dendritic cell", "d": ["A conventional thymic dendritic cell that is CD8alpha-positive."]}]}
{"type": "biolink:Cell", "ic": "51.662019661986122", "identifiers": [{"i": "UMLS:C0887899", "l": "Myeloid Cells", "d": []}, {"i": "NCIT:C12549", "l": "Myeloid Cell", "d": ["Cells which include the monocytes and the granulocytes."]}, {"i": "MESH:D022423", "l": "Myeloid Cells", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2924220", "l": "Cells.CD11c+CD103+", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C4524525", "l": "Derived Placental Blood Cell", "d": []}, {"i": "NCIT:C133262", "l": "Derived Placental Blood Cell", "d": ["Cells collected from placental blood."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C4085984", "l": "Anti-Programmed Cell Death Protein 1 Antibody Expressing Pluripotent Killer T-Lymphocytes", "d": []}, {"i": "NCIT:C125654", "l": "Anti-Programmed Cell Death Protein 1 Antibody Expressing Pluripotent Killer T-Lymphocytes", "d": ["A specific population of pluripotent killer (PIK) T-cells that have been induced to express high levels of antibodies against the negative immunoregulatory human cell surface receptor programmed cell death protein 1 (PD-1; PDCD1; CD279), with potential antitumor activity. Although the exact mechanism(s) of action through which PIK-PD-1 cells exert their effects has yet to be elucidated, upon infusion, these cells secrete antibodies that target PD-1 expressed on the surface of activated T-cells and tumor cells. This may block the interaction of PD-1 with its ligands, programmed cell death 1 ligand 1 (PD-L1, PD-1L1; CD274) and PD-1 ligand 2 (PD-L2, PD-1L2; CD273). The inhibition of ligand binding prevents PD-1-mediated signaling and results in both T-cell activation and the induction of T-cell-mediated immune responses against tumor cells. PD-1, an immunoglobulin (Ig) superfamily transmembrane protein and inhibitory receptor, negatively regulates T-cell activation; PD-L1 is overexpressed on certain cancer cells, and PD-L2 is primarily expressed on antigen presenting cells (APCs)."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C3641794", "l": "Gene-Modified HIV-Protected Hematopoietic Stem Cells", "d": []}, {"i": "NCIT:C104415", "l": "Gene-Modified HIV-Protected Hematopoietic Stem Cells", "d": ["Autologous hematopoietic stem cells (HSCs) genetically modified to be resistant to infection by human immunodeficiency virus (HIV). Allogeneic human autologous HSCs are isolated and transduced ex vivo with three different anti-HIV genes. Upon infusion into the HIV-infected lymphoma patient, the gene-modified HIV-protected HSCs are resistant to HIV entry and replication thereby preventing HIV infection in these proliferating stem cells and any differentiated cells that they give rise to. This results in the formation of immune cells resistant to HIV which also may be able to destroy HIV-infected cells."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0333859", "l": "Convoluted cell", "d": []}, {"i": "SNOMEDCT:33873001", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0682544", "l": "neutrophilic cell", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C4763651", "l": "Allogeneic Tri-functional Anti-CD19 CAR-NK Cells", "d": []}, {"i": "NCIT:C157484", "l": "Allogeneic Tri-functional Anti-CD19 CAR-NK Cells", "d": ["A preparation of allogeneic natural killer (NK) cells transduced with a retroviral vector expressing the immunostimulatory cytokine interleukin-15 (IL-15) and encoding a chimeric antigen receptor (CAR) specific for the tumor-associated antigen (TAA) cluster of differentiation 19 (CD19) that is coupled to the co-stimulatory domains cluster of differentiation 28 (CD28, T-cell-specific surface glycoprotein CD28), cluster of differentiation 137 (CD137; 4-1BB), and the zeta chain of the T-cell receptor (TCR)/CD3 complex (TCRzeta; CD247; CD3zeta); and a blocker for the inhibitory T-cell receptor programmed cell death protein 1 (PD-1; PDCD1; CD279), with potential immunomodulating and antineoplastic activities. Upon transfusion, the allogeneic tri-functional anti-CD19 CAR-NK cells recognize, bind to and induce selective cytotoxicity in CD19-expressing tumor cells. IL-15 enhances the cytotoxic effect of the NK cells and the activated anti-tumor T-cells. The PD-1 inhibitory domain targets and binds to programmed cell death-1 ligand 1 (PD-L1) expressed on tumor cells, thereby preventing the binding of the PD-1 on T-lymphocytes to its ligand, PD-L1 on tumor cells. This prevents PD-1/PD-L1-mediated inhibition of T-lymphocytes and leads to the activation and expansion of T-cells resulting in a cytotoxic T-lymphocyte (CTL) response against tumor cells, thereby enhancing the elimination of tumor cells. CD19 antigen is a B-cell specific cell surface antigen expressed in all B-cell lineage malignancies. The co-stimulatory signaling domains enhance both proliferation of T-cells and anti-tumor activity."]}]}
{"type": "biolink:Cell", "ic": "61.557258627229736", "identifiers": [{"i": "CL:0000192", "l": "smooth muscle cell", "d": ["A non-striated, elongated, spindle-shaped cell found lining the digestive tract, uterus, and blood vessels. They develop from specialized myoblasts (smooth muscle myoblast)."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5178678", "l": "Pseudo Pelger Huet cells | Blood | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "ic": "79.246894609297499", "identifiers": [{"i": "CL:1000410", "l": "myocyte of atrioventricular node", "d": ["A muscle cell that is part of the atrioventricular node."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2335624", "l": "Early promyelocyte", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0178813", "l": "protoplast/spheroplast", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5668443", "l": "Allogeneic Anti-CD33 CAR NK Cells", "d": []}, {"i": "NCIT:C183523", "l": "Allogeneic Anti-CD33 CAR NK Cells", "d": ["A preparation of off-the-shelf natural killer (NK) cells engineered to express a chimeric antigen receptor (CAR) specific for the cluster of differentiation 33 (CD33) antigen, with potential immunostimulating and antineoplastic activities. Upon administration, the allogeneic anti-CD33 CAR NK cells target and bind to CD33 expressed on the surface of tumor cells. This induces selective toxicity in tumor cells expressing CD33. CD33 is expressed on normal non-pluripotent hematopoietic stem cells and on myeloid leukemia cells."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002313", "l": "endocrine-paracrine cell of prostate gland", "d": ["An ecto-epithelial cell of the prostate gland that secretes hormones."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0011017", "l": "vagal neural crest cell", "d": ["Cell that is part of the vagal neural crest population. The vagal neural crest arises from the axial level of somites 1-7 and has been described as a hybrid between the head and the trunk populations."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1648296", "l": "Cells.CD38+Kappa+", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5668451", "l": "Autologous BCMA/TACI-targeted Trimeric APRIL-based CAR T Cells", "d": []}, {"i": "NCIT:C183542", "l": "Autologous BCMA/TACI-targeted Trimeric APRIL-based CAR T Cells", "d": ["A preparation of autologous T-lymphocytes that are genetically engineered to contain a dual-targeted chimeric antigen receptor (CAR), which includes a trimeric form of the natural protein a proliferation-inducing ligand (APRIL; TNFSF13), that targets the tumor-associated antigens (TAAs) B-cell maturation antigen (BCMA; TNFRSF17) and transmembrane activator and calcium modulator and cyclophilin ligand interactor (TACI; TNFRSF13B), with potential immunomodulating and antineoplastic activities. Upon administration, the autologous BCMA/TACI-targeted trimeric APRIL-based CAR T cells bind to BCMA and TACI expressed on tumor cells and induce selective cytotoxicity in those cells. BCMA and TACI, receptors for both APRIL and B-cell activating factor (BAFF), are members of the tumor necrosis factor receptor superfamily (TNFRSF). They are both found on the surfaces of plasma cells, overexpressed on malignant plasma cells and play key roles in plasma cell proliferation and survival. The incorporation of the trimeric, natural conformation of APRIL into the CAR enhances the binding to BCMA and TACI compared with the monomeric form of APRIL."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2336924", "l": "Myocardial endocrine cell of atrium", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157637", "l": "CD64 cells | Blood | Cell markers", "d": []}]}
{"type": "biolink:Cell", "ic": "68.949061832187297", "identifiers": [{"i": "CL:0000675", "l": "female gamete", "d": ["A mature sexual reproductive cell of the female germline."]}]}
{"type": "biolink:Cell", "ic": "86.236661114203869", "identifiers": [{"i": "CL:0000392", "l": "crystal cell", "d": ["A hemocyte that synthesizes and secretes melanins as part of the antimicrobial immune response. It is characterized morphologically by crystal inclusions of phenoloxidases in its cytoplasm, hence its name."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1181295", "l": "Meso-epithelial cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5154515", "l": "Basophils+Eosinophils+Monocytes/100 leukocytes | Blood | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5170923", "l": "Leukocytes | Buffy Coat | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "UMLS:C0206441", "l": "Pyramidal Cells", "d": []}, {"i": "NCIT:C12652", "l": "Pyramidal Cell", "d": ["A neuron located in the cerebral cortex, hippocampus, and amygdala that is characterized by a pyramidal-shaped cell body and apical and basal dendritic trees. Pyramidal cells are involved in complex cortical functions."]}, {"i": "MESH:D017966", "l": "Pyramidal Cells", "d": []}, {"i": "SNOMEDCT:17522008", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1517643", "l": "KA43", "d": []}, {"i": "NCIT:C20273", "l": "KA43", "d": ["Provider: Karolinska Institute, Stockholm, Sweden. No information from provider. This cell line meets the criteria for the use of human embryonic stem cells by federally funded researchers."]}]}
{"type": "biolink:Cell", "ic": "86.236661114203869", "identifiers": [{"i": "CL:0002036", "l": "Slamf1-positive multipotent progenitor cell", "d": ["A hematopoietic progenitor that has some limited self-renewal capability. Cells are lin-negative, Kit-positive, CD34-positive, and Slamf1-positive."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0004239", "l": "wavy bistratified amacrine cell", "d": ["A bistratified amacrine cell with a medium dendritic field and post-synaptic terminals in S1-S2, and S4."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157464", "l": "CD3+DR+ | White blood cells | Cell markers", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0228075", "l": "Small neuron", "d": []}, {"i": "SNOMEDCT:16868009", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5151351", "l": "Abnormal lymphocytes | Synovial fluid | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "ic": "83.552982069901191", "identifiers": [{"i": "UMLS:C1708860", "l": "Malignant Adenohypophysial Cell", "d": []}, {"i": "NCIT:C45973", "l": "Malignant Adenohypophysial Cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0230977", "l": "Desquamated fetal cells", "d": []}, {"i": "SNOMEDCT:67709004", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0333846", "l": "Binucleated plasmablast", "d": []}, {"i": "SNOMEDCT:11908008", "d": []}]}
{"type": "biolink:Cell", "ic": "44.581985784791243", "identifiers": [{"i": "CL:0000988", "l": "hematopoietic cell", "d": ["A cell of a hematopoietic lineage."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:4033053", "l": "small bistratified retinal ganglion cell", "d": ["A bistratfied retinal ganglion cell with a small dendritic field that has dendrites in the ON and OFF sublamina of the retinal inner plexiform layer and carries blue-ON/yellow-OFF signals. This cell receives bipolar and amacrine input to both the OFF and ON dendritic tree."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1179471", "l": "Surface mucous cell of stomach", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1292098", "l": "IgD B lymphocyte", "d": []}, {"i": "SNOMEDCT:115604004", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C3542977", "l": "Ependymoglial Cells", "d": []}, {"i": "MESH:D063928", "l": "Ependymoglial Cells", "d": []}]}
{"type": "biolink:Cell", "ic": "63.323668158560849", "identifiers": [{"i": "UMLS:C1518177", "l": "Malignant Epithelial Large Cell", "d": []}, {"i": "NCIT:C36822", "l": "Malignant Epithelial Large Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0000903", "l": "natural T-regulatory cell", "d": ["CD4-positive alpha-beta T cell with the phenotype FoxP3-positive, CD25-positive, CD62L-positive, and CTLA-4 positive with regulatory function."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2708700", "l": "Immature cells", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C4277543", "l": "Myeloid-Derived Suppressor Cells", "d": []}, {"i": "NCIT:C129908", "l": "Myeloid-Derived Suppressor Cell", "d": ["A population of myeloid cells, mainly dendritic cells, macrophages and neutrophils, that have immunosuppressive activity. During inflammation, chronic infection or cancer, these cells may promote angiogenesis or tumor cell invasion."]}, {"i": "MESH:D000072737", "l": "Myeloid-Derived Suppressor Cells", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157440", "l": "CD3+CD4+CD27+CD45RO+CD62L+ cells | Blood | Cell markers", "d": []}]}
{"type": "biolink:Cell", "ic": "54.752393246735153", "identifiers": [{"i": "CL:0000325", "l": "stuff accumulating cell", "d": ["A cell that is specialised to accumulate a particular substance(s)."]}]}
{"type": "biolink:Cell", "ic": "64.483855464319362", "identifiers": [{"i": "CL:0000451", "l": "dendritic cell", "d": ["A cell of hematopoietic origin, typically resident in particular tissues, specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation. These cells are lineage negative (CD3-negative, CD19-negative, CD34-negative, and CD56-negative)."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5172508", "l": "Mesothelial cells | Synovial fluid | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5669238", "l": "Allogeneic CRISPR-edited Anti-CD19 CAR T Cells PACE CART19", "d": []}, {"i": "NCIT:C184372", "l": "Allogeneic CRISPR-edited Anti-CD19 CAR T Cells PACE CART19", "d": ["An off-the-shelf (OTS) preparation of human allogeneic T-lymphocytes transduced with a lentiviral vector encoding a chimeric antigen receptor (CAR) consisting of an anti-CD19 single chain variable fragment (scFv) and the co-stimulatory domain 4-1BB (CD137) coupled to the zeta chain of the T-cell receptor (TCR)/CD3 complex (CD3-zeta), and electroporated with clustered regularly interspaced short palindromic repeats (CRISPR)-Cas9 nuclease complex to eliminate the expression of endogenous TCR, HLA class I and HLA class II molecules, with potential immunostimulating and antineoplastic activities. Upon administration, allogeneic CRISPR-edited anti-CD19 CAR T cells PACE CART19 recognize and bind to CD19-expressing tumor cells. This may result in a specific cytotoxic T-lymphocyte (CTL)-mediated killing of CD19-expressing tumor cells. The removal of endogenous TCR, HLA class I and HLA class II molecules prevents allogeneic immune responses and reduces the risk of graft-versus-host disease (GvHD). The tumor-associated antigen (TAA) CD19 is a B-cell specific cell surface antigen overexpressed in B-cell lineage malignancies."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0000719", "l": "posterior cone cell (sensu Endopterygota)", "d": []}]}
{"type": "biolink:Cell", "ic": "90.82444074280258", "identifiers": [{"i": "CL:0003024", "l": "retinal ganglion cell C inner", "d": ["A retinal ganglion cell C with medium cell bodies and large dendritic field."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0682694", "l": "Inhibitory interneuron", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1267891", "l": "Lymphocyte positive for CD21 antigen", "d": []}, {"i": "SNOMEDCT:116843006", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:4033033", "l": "flat midget bipolar cell", "d": ["An OFF bipolar cell with a small dendritic tree that provides most of the triad-associated basal (flat) contacts at cone pedicles."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0000425", "l": "pore cell", "d": ["Forms the terminal part of the cuticle-lined excretory duct of C. elegans."]}]}
{"type": "biolink:Cell", "ic": "87.120474278337809", "identifiers": [{"i": "UMLS:C1708899", "l": "Malignant Parathyroid Gland Chief Cell", "d": []}, {"i": "NCIT:C48269", "l": "Malignant Parathyroid Gland Chief Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0011024", "l": "double negative T regulatory cell", "d": ["A double negative thymocyte that is CD3-positive, CD4-negative, CD8-negative, that that are present in the periphery in very low numbers and predominantly produce INF-gamma, TNF-alpha, and a low amount of TGF-beta, but not IL-2, IL-4, IL-10 or IL-13 upon activation."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0009073", "l": "medullary thymic epithelial cell type 3", "d": ["A thymic medullary epithelial cell considered to be a post-AIRE cell. This group of AIRE-mTECs is heterogeneous and also includes mTECs within Hassall's Corpuscles."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:1000357", "l": "microfold cell of epithelium proper of jejunum", "d": ["A M cell that is part of the epithelium proper of jejunum."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5181368", "l": "Spermatozoa Progressive | Semen | Fertility testing", "d": []}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "CL:0009092", "l": "endothelial cell of placenta", "d": ["An endothelial cell that is part of a placenta."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1518113", "l": "MB01", "d": []}, {"i": "NCIT:C20275", "l": "MB01", "d": ["Provider: Maria Biotech Co. Ltd. - Maria Infertility Hospital Medical Institute, Seoul, Korea. Information from provider and not independently verified by NIH: Cells are positive for cell markers Oct-4, alkaline phosphatase activity and telomerase activity; Differentiate in vitro into mature neuron, glia cells, muscle cells and beating cardiomyocytes; AFP was also detected in this cells. This cell line meets the criteria for the use of human embryonic stem cells by federally funded researchers."]}]}
{"type": "biolink:Cell", "ic": "74.953330836288131", "identifiers": [{"i": "CL:0000128", "l": "oligodendrocyte", "d": ["A class of large neuroglial (macroglial) cells in the central nervous system. Form the insulating myelin sheath of axons in the central nervous system."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1979744", "l": "Leukocytes.CD59 deficient", "d": []}]}
{"type": "biolink:Cell", "ic": "86.236661114203869", "identifiers": [{"i": "CL:0000832", "l": "eosinophilic myeloblast", "d": ["A myeloblast committed to the eosinophil lineage."]}]}
{"type": "biolink:Cell", "ic": "75.26123597683771", "identifiers": [{"i": "CL:0002428", "l": "double-positive blast", "d": ["A double-positive thymocyte that is large (i.e. has a high forward scatter signal in flow cytometry) and is actively proliferating."]}]}
{"type": "biolink:Cell", "ic": "90.82444074280258", "identifiers": [{"i": "CL:1001505", "l": "parvocellular neurosecretory cell", "d": ["The secretory neurons of the paraventricular nucleus that synthesize and secrete vasopressin, corticotropin-releasing factor (CRF) and thyrotropin-releasing hormone (TRH) into blood vessels in the hypothalamo-pituitary portal system."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5667111", "l": "Autologous mbIL-12-expressing Tumor Infiltrating Lymphocytes GT202", "d": []}, {"i": "NCIT:C187050", "l": "Autologous mbIL-12-expressing Tumor Infiltrating Lymphocytes GT202", "d": ["A preparation of autologous tumor infiltrating lymphocytes (TILs) engineered to express membrane-bound interleukin-12 (mbIL-12), with potential immunomodulating and antineoplastic activities. The TILs are isolated from an autologous tumor sample and engineered to express mbIL-12. Upon infusion of the autologous mbIL-12-expressing TILs GT202 back into the patient, the cells specifically recognize, target and kill the patient's tumor cells. IL-12 expression activates the immune system by promoting the secretion of interferon-gamma (IFNg), activating natural killer cells (NKs), and inducing cytotoxic T-lymphocyte (CTL) responses, further killing tumor cells."]}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "CL:0002530", "l": "immature CD1a-positive dermal dendritic cell", "d": ["An immature CD1a-positive dermal dendritic cell is CD80-low, CD86-low, and MHCII-low."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5447112", "l": "Autologous Anti-GPRC5D-CAR-4-1BB-expressing T-cells MCARH109", "d": []}, {"i": "NCIT:C176222", "l": "Autologous Anti-GPRC5D-CAR-4-1BB-expressing T-cells MCARH109", "d": ["A preparation of autologous T-lymphocytes that have been transduced with a retroviral vector expressing a chimeric antigen receptor (CAR) containing a single chain variable fragment (scFv) specific for the tumor-associated antigen (TAA) human G-protein coupled receptor family C group 5 member D (GPRC5D) and the co-stimulatory domain 4-1BB (CD137), with potential immunostimulating and antineoplastic activities. Upon leukapheresis, isolation, transduction, expansion ex vivo, and reintroduction into the patient, the autologous anti-GPRC5D-CAR-4-1BB-expressing T-cells MCARH109 specifically recognize and induce selective toxicity in GPRC5D-expressing tumor cells. GPRC5D is overexpressed in certain malignancies, such as multiple myeloma, while minimally expressed in normal, healthy cells. It plays a key role in tumor cell proliferation."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5173430", "l": "Monocytes | Blood | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2332843", "l": "Enterocyte of epithelium of small intestine", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1518789", "l": "PG13/LNc8 Retroviral Transduced Cloned T-Cells", "d": []}, {"i": "NCIT:C2790", "l": "PG13/LNc8 Retroviral Transduced Cloned T-Cells", "d": ["A preparation of T lymphocytes harvested from a patient with cancer and transduced with the PG13/Lnc8 retroviral vector, a clone of the LN vector that encodes the neomycin phosphotransferase gene.  The modified T lymphocytes are cloned using an ex vivo technique and infused back into the patient, where they may elicit a host immune response against tumor cells.  The neomycin phosphotransferase gene product has no direct therapeutic value; it serves as a molecular marker to monitor the presence and localization of the PG13/Lnc8-transduced T-lymphocytes in the host. (NCI04)"]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5447330", "l": "iPSC-derived CD16/IL-15RF-expressing CD38-eliminated NK Cells FT538", "d": []}, {"i": "NCIT:C176623", "l": "iPSC-derived CD16/IL-15RF-expressing CD38-eliminated NK Cells FT538", "d": ["An allogeneic, off-the-shelf, natural killer (NK) cell product derived from a clonal master induced pluripotent stem cell (iPSC) line, and engineered and CRISPR-edited to express a high-affinity, non-cleavable CD16 (hnCD16) Fc receptor and a recombinant fusion of IL-15 and IL-15 receptor alpha (IL-15RF), and to eliminate CD38 expression, with potential immunostimulatory and antineoplastic activities. Upon administration, iPSC-derived CD16/IL-15RF-expressing CD38-eliminated NK cells FT538 bind to stress-induced ligands on tumor cells, leading to tumor cell lysis and release of tumor neoantigens. Additionally, FT538 NK cells secrete inflammatory cytokines and chemokines, thereby enhancing T-cell activity and recruitment to the tumor site. IL-15RF promotes the survival of NK cells and enhances the cytotoxic effect of the NK cells and the activated anti-tumor T-cells. When used in combination with monoclonal antibodies, the hnCD16 Fc receptor of FT538 binds to the Fc portion of tumor cell-bound monoclonal antibodies, leading to NK cell activation, cytokine secretion and enhanced antibody-dependent cellular cytotoxicity (ADCC). CD16, also known as Fc-gamma receptor III, is normally expressed on the surface of NK cells, neutrophils, monocytes and macrophages, and plays a key role in initiating ADCC. It is often downregulated in certain cancers, thereby inhibiting the anti-tumor immune response. The lack of CD38 in FT538 NK cells prevents NK cell fratricide upon co-administration with a CD38-targeting monoclonal antibody as CD38 is normally expressed on the surface of activated NK cells. This enhances ADCC mediated by CD38-targeting monoclonal antibodies."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C3273371", "l": "CD4 Positive Memory T-Lymphocyte", "d": []}, {"i": "NCIT:C97349", "l": "CD4 Positive Memory T-Lymphocyte", "d": ["A mature T lymphocyte that has encountered antigen at a previous time and is primed to react strongly during its next encounter with that antigen. These cells can be identified by the presence of both the CD4 and CD45RO molecules on their surface."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C3178914", "l": "B-Lymphocytes, Regulatory", "d": []}, {"i": "NCIT:C113502", "l": "Regulatory B Cell", "d": ["A subset of B-cells that can negatively regulate immune responses mediated by T-cells. These B-lymphocytes produce interleukin-10."]}, {"i": "MESH:D060151", "l": "B-Lymphocytes, Regulatory", "d": []}]}
{"type": "biolink:Cell", "ic": "88.140761698499901", "identifiers": [{"i": "CL:0002503", "l": "adventitial cell", "d": ["A cell of the adventitial layer of ductal structures such as the uterer, defent duct, biliary duct, etc"]}]}
{"type": "biolink:Cell", "ic": "73.011730055819953", "identifiers": [{"i": "UMLS:C1516595", "l": "Classical Reed-Sternberg Cell", "d": []}, {"i": "NCIT:C39720", "l": "Classical Reed-Sternberg Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "80.869303025598512", "identifiers": [{"i": "CL:0000464", "l": "epidermoblast", "d": ["An epidermal progenitor cell that arises from neuroectoderm and in turn gives rise to the epidermal sheath of ventral and cephalic regions."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1522238", "l": "Thyroid Gland - Follicular Cell (MMHCC)", "d": []}, {"i": "NCIT:C22652", "l": "Mouse Thyroid Gland Follicular Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002116", "l": "B220-low CD38-positive unswitched memory B cell", "d": ["A B220-low CD38-positive unswitched memory B cell is a CD38-positive unswitched memory B cell that has the phenotype B220-low, CD38-positive, IgD-positive, CD138-negative, and IgG-negative."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5219006", "l": "Erythrocytes|NCnc|Urine", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2338276", "l": "Microfold cell of epithelium proper of small intestine", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0000435", "l": "alkali secreting cell", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002277", "l": "type I enteroendocrine cell", "d": ["An enteroendocrine cell commonest in the duodenum and jejunum, rare in ileum, that secretes cholecystokinin. This cell type is involved in the regulation of digestive enzymes and bile."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0521391", "l": "Central motor neuron", "d": []}, {"i": "SNOMEDCT:61548005", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2330901", "l": "Set of granulocytes", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002151", "l": "late promyelocyte", "d": ["A promyelocyte that is considerably smaller, with more condensed chromatin, and nucleoli are no longer conspicuous."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:4033022", "l": "mucus secreting cell of bronchus submucosal gland", "d": ["A mucus secreting cell of a submucosal gland of the bronchus."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002622", "l": "prostate stromal cell", "d": ["A stromal cell of the prostate."]}]}
{"type": "biolink:Cell", "ic": "56.592817335335198", "identifiers": [{"i": "UMLS:C1517736", "l": "Large Osteoclastic Giant Cell", "d": []}, {"i": "NCIT:C36818", "l": "Large Osteoclastic Giant Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0009048", "l": "anorectum macrophage", "d": ["A macrophage that is located in the anorectum."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002179", "l": "foveolar cell of stomach", "d": ["An epithelial cell within one of the pits in the embryonic gastric mucosa from which the gastric glands develop ."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5571707", "l": "Erythrocytes.ghost cells|Urine/Urine sed", "d": []}]}
{"type": "biolink:Cell", "ic": "80.17194633000733", "identifiers": [{"i": "UMLS:C1708884", "l": "Malignant Hyperchromatic Squamous Cell", "d": []}, {"i": "NCIT:C54208", "l": "Malignant Hyperchromatic Squamous Cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5216299", "l": "Nucleated cells|NCnc|Pt|CSF", "d": []}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "CL:0008032", "l": "rosehip neuron", "d": ["A GABAergic interneuron in human cortical layer 1 that has large rosehip-shaped axonal boutons and compact arborization."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2713244", "l": "Pooled platelet concentrate", "d": []}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "CL:0000608", "l": "zygospore", "d": ["A thick walled, sexual, resting spore formed by Zygomycetes; sometimes refers to the spore and the multi-layered cell wall that encloses the spore, the zygosporangium."]}]}
{"type": "biolink:Cell", "ic": "66.618744678332945", "identifiers": [{"i": "CL:0000159", "l": "seromucus secreting cell", "d": []}]}
{"type": "biolink:Cell", "ic": "63.195144374262064", "identifiers": [{"i": "UMLS:C1513970", "l": "Neoplastic Ganglion Cell", "d": []}, {"i": "NCIT:C37146", "l": "Neoplastic Ganglion Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "88.140761698499901", "identifiers": [{"i": "CL:0000189", "l": "slow muscle cell", "d": ["A muscle cell that develops tension more slowly than a fast-twitch fiber."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1440232", "l": "Cells.CD10+CD19+", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2326607", "l": "Adipocyte of epicardial fat of left ventricle", "d": []}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "CL:0002613", "l": "striatum neuron", "d": ["A neuron of the striatum."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:1000691", "l": "kidney interstitial myofibroblast", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1440409", "l": "Cells.t(2;5)(p23;q35.1)(ALK,NPM1)", "d": []}]}
{"type": "biolink:Cell", "ic": "72.900487657105927", "identifiers": [{"i": "CL:0008008", "l": "striated visceral muscle cell", "d": ["A visceral muscle cell that is striated.  Examples include the visceral muscle cells of arhtropods."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5543953", "l": "MON002", "d": []}, {"i": "MESH:C000715488", "l": "MON002", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1440344", "l": "Cells.CD66b", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157447", "l": "CD3+CD5+ cells | Cerebral spinal fluid | Cell markers", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1257742", "l": "BALB 3T3 clone A31", "d": []}]}
{"type": "biolink:Cell", "ic": "92.728541327098611", "identifiers": [{"i": "CL:0002258", "l": "thyroid follicular cell", "d": ["A cell type that varies from squamous to columnar, depending on their activity with microvillus directed luminally. This cell produces and secretes thyroid hormones."]}]}
{"type": "biolink:Cell", "ic": "78.96520244130248", "identifiers": [{"i": "CL:0000810", "l": "CD4-positive, alpha-beta thymocyte", "d": ["An immature alpha-beta T cell that is located in the thymus and is CD4-positive and CD8-negative."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5572422", "l": "Superficial transitional cells | Urine sediment | Urinalysis", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0301864", "l": "Target cell of immunologic reaction", "d": []}, {"i": "SNOMEDCT:56709009", "d": []}]}
{"type": "biolink:Cell", "ic": "89.347505587204751", "identifiers": [{"i": "CL:4023087", "l": "fan Martinotti neuron", "d": ["A Martinotti neuron that has axons that form a fan-like plexus."]}]}
{"type": "biolink:Cell", "ic": "92.728541327098611", "identifiers": [{"i": "CL:0000783", "l": "multinucleated phagocyte", "d": ["A phagocyte formed by the fusion of mononuclear phagocytes."]}]}
{"type": "biolink:Cell", "ic": "66.969489883774216", "identifiers": [{"i": "UMLS:C0206131", "l": "Adipocytes", "d": []}, {"i": "NCIT:C12556", "l": "Adipocyte", "d": ["A connective tissue cell that is specialized to synthesize and store fat."]}, {"i": "MESH:D017667", "l": "Adipocytes", "d": []}, {"i": "SNOMEDCT:24826007", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C3178760", "l": "Mirror Neurons", "d": []}, {"i": "MESH:D059167", "l": "Mirror Neurons", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5155166", "l": "Blasts | Blood cord | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4277680", "l": "Adipocytes, Beige", "d": []}, {"i": "MESH:D000069797", "l": "Adipocytes, Beige", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002614", "l": "neuron of the substantia nigra", "d": ["A neuron of the substantia nigra."]}]}
{"type": "biolink:Cell", "ic": "87.120474278337809", "identifiers": [{"i": "CL:0002153", "l": "corneocyte", "d": ["The dead keratin-filled squamous cell of the stratum corneum. This cell type lacks a nucleus."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0001003", "l": "mature CD8_alpha-negative CD11b-positive dendritic cell", "d": ["Mature CD8_alpha-negative CD11b-positive dendritic cell is a CD8_alpha-negative CD11b-positive dendritic cell that is CD80-high, CD86-high, MHCII-high and is CD83-positive."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157498", "l": "CD34+CD117+ blasts | Bone marrow | Cell markers", "d": []}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "CL:0002443", "l": "Ly49CI-positive natural killer cell, mouse", "d": ["A NK1.1-positive T cell that is Ly49Cl-positive."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1522235", "l": "Exocrine Pancreas - Acinar Cell (MMHCC)", "d": []}, {"i": "NCIT:C22643", "l": "Mouse Acinar Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "73.976162571356099", "identifiers": [{"i": "UMLS:C0151776", "l": "Abnormal megakaryocyte", "d": []}, {"i": "NCIT:C37043", "l": "Abnormal Megakaryocyte", "d": []}, {"i": "SNOMEDCT:68425008", "d": []}]}
{"type": "biolink:Cell", "ic": "70.914165308394445", "identifiers": [{"i": "UMLS:C1512140", "l": "ES Cell Line", "d": []}, {"i": "NCIT:C20232", "l": "ES Cell Line", "d": ["Stable cell lines derived from embryonic stem cells.  They can be propagated indefinitely in the primitive undifferentiated state while remaining pluripotent."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1179186", "l": "Serous cell", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:4033045", "l": "lung migratory dendritic cell", "d": ["A dendritic cell that captures antigens in a lung and migrates to a lymph node or to the spleen to activate T cells."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2339724", "l": "Set of cholinergic cells of olfactory tubercle [Ch4]", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0596630", "l": "granule cell", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C4288532", "l": "PDCD-1 Knockout Autologous T-lymphocytes", "d": []}, {"i": "NCIT:C128281", "l": "PDCD-1 Knockout Autologous T-lymphocytes", "d": ["A population of engineered autologous T-lymphocytes in which the gene encoding for the programmed cell death protein 1 (PDCD-1) is deleted, with potential immunomodulating activity. Following collection of peripheral blood lymphocytes and selection of T-cells, the PDCD-1 gene was knocked out and the T-cells were expanded. Upon reinfusion of the PDCD-1 knockout T-lymphocytes, these T-cells target and lyse cancer cells. The PDCD-1 protein, found on activated T-cells and often overexpressed on T-cells in cancer patients, negatively regulates T-cell activity; it plays a key role in immune evasion and prevents tumor cell lysis. PDCD-1 knockout enhances cytotoxicity and T-cell-mediated anti-tumor immune responses."]}]}
{"type": "biolink:Cell", "ic": "92.728541327098611", "identifiers": [{"i": "CL:0000999", "l": "CD4-positive CD11b-positive dendritic cell", "d": ["CD8_alpha-negative CD11b-positive dendritic cell is a conventional dendritic cell that is CD11b-positive, CD4-positive and is CD205-negative and CD8_alpha-negative."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157265", "l": "CD11a blasts | Blood | Cell markers", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C2698131", "l": "Anti-CEA TCR Retroviral Vector-Transduced Autologous Peripheral Blood Lymphocytes", "d": []}, {"i": "NCIT:C79842", "l": "Anti-CEA TCR Retroviral Vector-Transduced Autologous Peripheral Blood Lymphocytes", "d": ["Autologous human peripheral blood lymphocytes (PBLs), transduced with a retroviral vector encoding both the alpha and beta chains of a T cell receptor (TCR) specific for the carcinoembryonic antigen (CEA), with potential immunostimulating and antineoplastic activities. After transduction, expansion in culture, and reintroduction into the patient, anti-CEA TCR retroviral vector-transduced autologous lymphocytes bind to tumor cells expressing CEA, which may result in cytokine expression, activation and proliferation of T-cells, and a specific cytotoxic T-lymphocyte (CTL) response against CEA-expressing tumor cells. The tumor-associated antigen (TAA) CEA is overexpressed by a variety of cancer cell types, including those of the gastrointestinal tract, lung, and breast."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1267978", "l": "Lymphocyte positive for CD88 antigen", "d": []}, {"i": "SNOMEDCT:117418000", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5216249", "l": "Lymphocytes|NCnc|Pt|Bld", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4068113", "l": "Cells.CD3+CD4+CD8+", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1829707", "l": "Cells.ZAP70+CD19+", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C3495990", "l": "Acg noradrenaline cells", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4246711", "l": "Vascular smooth muscle cell of left coronary artery", "d": []}]}
{"type": "biolink:Cell", "ic": "89.347505587204751", "identifiers": [{"i": "CL:0002256", "l": "supporting cell of carotid body", "d": ["A supportive cell that has characteristics of glial cell. Processes of this cell envelope the junctions between glomus cells and nerve endings."]}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "CL:2000036", "l": "anterior lateral line neuromast supporting cell", "d": ["Any neuromast support cell that is part of a anterior lateral line."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4505105", "l": "Oligodendrocyte Precursor Cells", "d": []}, {"i": "MESH:D000073637", "l": "Oligodendrocyte Precursor Cells", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5447453", "l": "Autologous Anti-HER2 CAR Macrophages CT-0508", "d": []}, {"i": "NCIT:C176824", "l": "Autologous Anti-HER2 CAR Macrophages CT-0508", "d": ["A preparation of autologous macrophages transduced with the adenoviral vector Ad5f35 to express a chimeric antigen receptor (CAR) targeting the tumor-associated antigen (TAA) human epidermal growth factor receptor 2 (EGFR2; HER2; ErbB2), with potential immunostimulatory and antineoplastic activities. Upon administration, autologous anti-HER2 CAR Macrophages (CAR-M) CT-0508 specifically recognize and bind to HER2-expressing tumor cells, resulting in the phagocytosis of HER2-expressing tumor cells. CAR-M CT-0508 maintain the pro-inflammatory, anti-tumor M1 phenotype within the human tumor microenvironment (TME). In addition, CAR-M CT-0508 may activate an anti-tumor T-lymphocyte immune response resulting in T-cell-mediated killing of tumor cells. HER2, a receptor tyrosine kinase that is mutated or overexpressed in many tumor cell types, plays an important role in tumor cell proliferation and tumor vascularization."]}]}
{"type": "biolink:Cell", "ic": "76.10017597303252", "identifiers": [{"i": "CL:0000351", "l": "trophoblast cell", "d": ["A cell lining the outside of the blastocyst. After binding to the endometrium, trophoblast cells develop into two distinct layers, an inner layer of mononuclear cytotrophoblast cells and an outer layer of continuous multinuclear cytoplasm, the syncytiotrophoblast cells, which form the early fetal-maternal interface."]}]}
{"type": "biolink:Cell", "ic": "74.37742281270377", "identifiers": [{"i": "UMLS:C0228092", "l": "Ependymal cell", "d": []}, {"i": "NCIT:C13003", "l": "Ependymal Cell", "d": ["A cell that lines cavities in the central nervous system.  It is considered to be a type of glial cell."]}, {"i": "SNOMEDCT:46940003", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1514891", "l": "Reserve Stem Cell", "d": []}, {"i": "NCIT:C33464", "l": "Reserve Stem Cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C3176805", "l": "Blasts.cytoplasmic CD22", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5419314", "l": "elivaldogene autotemcel", "d": []}, {"i": "NCIT:C171808", "l": "Elivaldogene Autotemcel", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5161804", "l": "Cytoplasmic Ig mu cells | Blood | Cell markers", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1267919", "l": "Lymphocyte positive for CD41A antigen", "d": []}, {"i": "SNOMEDCT:117587004", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1440295", "l": "Cells.CD33+CD11b+", "d": []}]}
{"type": "biolink:Cell", "ic": "67.014669355571556", "identifiers": [{"i": "CL:4023069", "l": "medial ganglionic eminence derived GABAergic cortical interneuron", "d": ["A GABAergic cortical interneuron that develops from the medial ganglionic eminence and has migrated to the cerebral cortex."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0009070", "l": "corticomedullary thymic epithelial cell", "d": ["A thymic epithelial cell located at the corticomedullary junction."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1441141", "l": "Immature reticulocyte", "d": []}, {"i": "SNOMEDCT:409888001", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5426956", "l": "Epithelial cells | Prostatic fluid | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "ic": "69.858950277264299", "identifiers": [{"i": "UMLS:C1514038", "l": "Neoplastic Myeloid Blast", "d": []}, {"i": "NCIT:C37067", "l": "Neoplastic Myeloid Blast", "d": []}]}
{"type": "biolink:Cell", "ic": "79.849015605436421", "identifiers": [{"i": "CL:0002043", "l": "CD34-positive, CD38-negative multipotent progenitor cell", "d": ["A hematopoietic multipotent progenitor cell that is CD34-positive, CD38-negative, CD45RA-negative, and CD90-negative."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C3897094", "l": "IL13Ralpha2-specific Hinge-optimized 41BB-co-stimulatory CAR Truncated CD19-expressing Autologous T-Lymphocytes", "d": []}, {"i": "NCIT:C117233", "l": "IL13Ralpha2-specific Hinge-optimized 41BB-co-stimulatory CAR Truncated CD19-expressing Autologous T-Lymphocytes", "d": ["A preparation of ex vivo expanded, genetically modified autologous central memory-enriched T-cells (Tcm) transduced with a replication incompetent, self-inactivating (SIN) lentiviral vector expressing a hinge-optimized, chimeric antigen receptor (CAR) specific for interleukin-13 receptor alpha 2 (IL13Ra2), and containing the cluster of differentiation 137 (CD137; 4-1BB) co-stimulatory signaling domain fused to the signaling domain of the T cell antigen receptor complex zeta chain (CD3-zeta), and a truncated form of human cluster of differentiation 19 (CD19t), with potential immunostimulating and antineoplastic activities. Upon intratumoral or intracavitary administration, IL13Ra2-specific, hinge-optimized, 41BB-co-stimulatory CAR/truncated CD19 expressing T-lymphocytes are directed to, and induce selective toxicity and cytolysis in IL13Ra2-expressing tumor cells. IL13Ra2, overexpressed by a variety of tumor cell types, is associated with increased tumor cell proliferation, migration and invasiveness. The costimulatory signaling domain enhances both proliferation of T-cells and antitumor activity. Hinge optimization prevents the recognition and clearance of the CAR by endogenous Fc receptors (FcRs). CD19t is used as a surface marker to both quantify and track the gene modified T-cells in vivo."]}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "UMLS:C0427526", "l": "Large granular lymphocyte", "d": []}, {"i": "NCIT:C12921", "l": "Large Granular Lymphocyte", "d": ["A population of large-sized lymphocytes found in human peripheral blood with slightly eccentric nuclei and abundant cytoplasmic azurophilic granules. This population of cells can be comprised of normal natural killer (NK) cells."]}, {"i": "SNOMEDCT:250285008", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4253020", "l": "Set of type B cells of pancreatic islet", "d": []}]}
{"type": "biolink:Cell", "ic": "84.128890093485552", "identifiers": [{"i": "CL:4023015", "l": "sncg GABAergic cortical interneuron", "d": ["A GABAergic neuron located in the cerebral cortex that expresses Gamma-synuclein"]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1267825", "l": "T lymphocyte positive for both CD4 antigen and HLA-DR antigen", "d": []}, {"i": "SNOMEDCT:115405007", "d": []}]}
{"type": "biolink:Cell", "ic": "81.648881485605159", "identifiers": [{"i": "UMLS:C1512565", "l": "Hypolobated Megakaryocyte", "d": []}, {"i": "NCIT:C37047", "l": "Hypolobated Megakaryocyte", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0000660", "l": "glycocalyx secreting cell", "d": ["An extracellular matrix secreting cell that secretes glycocalyx."]}]}
{"type": "biolink:Cell", "ic": "92.728541327098611", "identifiers": [{"i": "CL:0002526", "l": "CD14-positive dermal dendritic cell", "d": ["A dermal dendritic cell that is CD1a-negative and CD14-positive."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1513745", "l": "Multinucleated Keratinocyte", "d": []}, {"i": "NCIT:C36748", "l": "Multinucleated Keratinocyte", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002459", "l": "langerin-negative dermal dendritic cell", "d": ["A dermal dendritic cell that is langerin-negative, CD103-negative, and CD11b-positive."]}]}
{"type": "biolink:Cell", "ic": "67.014669355571556", "identifiers": [{"i": "CL:4033054", "l": "perivascular cell", "d": ["A cell that is adjacent to a vessel. A perivascular cell plays a crucial role in maintaining vascular function and tissue homeostasis. This cell type regulates vessel integrity and flow dynamics."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:1000484", "l": "Purkinje myocyte of atrioventricular bundle", "d": ["A Purkinje myocyte that is part of the atrioventricular bundle."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002578", "l": "mesenteric preadipocyte", "d": ["A preadipocyte found in mesenteric tissue."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1518219", "l": "Malignant Neuroendocrine Fusiform Small Cell", "d": []}, {"i": "NCIT:C36720", "l": "Malignant Neuroendocrine Fusiform Small Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "61.246643653717491", "identifiers": [{"i": "CL:0000791", "l": "mature alpha-beta T cell", "d": ["A alpha-beta T cell that has a mature phenotype."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5417817", "l": "iPSC-derived CD16/IL-15RF-expressing Anti-CD19 CAR-NK Cells FT596", "d": []}, {"i": "NCIT:C170800", "l": "iPSC-derived CD16/IL-15RF-expressing Anti-CD19 CAR-NK Cells FT596", "d": ["An allogeneic, off-the-shelf, chimeric antigen receptor (CAR)-natural killer (NK) cell product derived from a clonal master induced pluripotent stem cell (iPSC) line, and engineered to express a NK cell-specific anti-CD19 CAR, a high-affinity, non-cleavable CD16 (hnCD16) Fc receptor, and a recombinant fusion of IL-15 and IL-15 receptor alpha (IL-15RF), with potential immunostimulatory and antineoplastic activities. Upon administration, iPSC-derived CD16/IL-15RF-expressing Anti-CD19 CAR-NK Cells FT596 recognize, bind to and induce selective cytotoxicity in CD19-expressing tumor cells. IL-15RF enhances the cytotoxic effect of the NK cells and the activated anti-tumor T-cells. When used in combination with monoclonal antibodies, the hnCD16 Fc receptor of FT596 binds to the Fc portion of tumor cell-bound monoclonal antibodies, leading to NK cell activation, cytokine secretion and enhanced antibody-dependent cellular cytotoxicity (ADCC). CD19 antigen is a B-cell specific cell surface antigen expressed in all B-cell lineage malignancies. CD16, also known as Fc-gamma receptor III, is normally expressed on the surface of NK cells, neutrophils, monocytes and macrophages, and plays a key role in initiating ADCC. It is often downregulated in certain cancers, thereby inhibiting the anti-tumor immune response."]}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "UMLS:C1708872", "l": "Malignant Epithelial Cell with Ground Glass Cytoplasm", "d": []}, {"i": "NCIT:C54589", "l": "Malignant Epithelial Cell with Ground Glass Cytoplasm", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C3496266", "l": "B3 serotonin cells", "d": []}]}
{"type": "biolink:Cell", "ic": "75.923665061460838", "identifiers": [{"i": "UMLS:C1881561", "l": "Malignant Intermediate Type Trophoblastic Cell", "d": []}, {"i": "NCIT:C61405", "l": "Malignant Intermediate Type Trophoblastic Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "80.511444690059548", "identifiers": [{"i": "CL:0000323", "l": "lysozyme secreting cell", "d": []}]}
{"type": "biolink:Cell", "ic": "68.312708028507217", "identifiers": [{"i": "CL:0000740", "l": "retinal ganglion cell", "d": ["The set of neurons that receives neural inputs via bipolar, horizontal and amacrine cells. The axons of these cells make up the optic nerve."]}]}
{"type": "biolink:Cell", "ic": "71.975435936396124", "identifiers": [{"i": "UMLS:C5446926", "l": "Anti-CD19-targeting CAR-T Cells", "d": []}, {"i": "NCIT:C176018", "l": "Anti-CD19-targeting CAR-T Cells", "d": ["Any preparation of CAR-T cells that targets CD19."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:1000332", "l": "serous cell of epithelium of terminal bronchiole", "d": ["A serous secreting cell that is part of the epithelium of terminal bronchiole."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5401387", "l": "Autologous Blinatumomab-expanded T-Cells", "d": []}, {"i": "NCIT:C170899", "l": "Autologous Blinatumomab-expanded T-Cells", "d": ["A preparation of autologous, peripheral blood-derived polyclonal activated T-cells that have been expanded and activated ex-vivo using blinatumomab and recombinant human IL2 (rhIL-2) and depleted of contaminating CD19+ tumor cells, with potential immunomodulating activity. Upon administration, these blinatumomab-expanded T-cells (BET), composed of functional polyclonal CD4+ and CD8+ T-cells and mostly effector and central memory cells, may induce immunological recovery. BET cell expansion leads to the lysis and elimination of contaminating CD19+ tumor cells. The elimination of contaminating tumor cells is important in the treatment of non-Hodgkin CD20 + indolent lymphoma (iNHL) and chronic lymphatic leukemia (CLL)."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0080202", "l": "T-Lymphocyte Subsets", "d": []}, {"i": "MESH:D016176", "l": "T-Lymphocyte Subsets", "d": []}]}
{"type": "biolink:Cell", "ic": "77.271239091128209", "identifiers": [{"i": "CL:0000819", "l": "B-1 B cell", "d": ["A B cell of distinct lineage and surface marker expression. B-1 B cells are thought to be the primary source of natural IgM immunoglobulin, that is, IgM produced in large quantities without prior antigenic stimulation and generally reactive against various microorganisms, as well as the source of T-independent IgA immunoglobulin in the mucosal areas. These cells are CD43-positive."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1648297", "l": "Cells.CD38+Lambda+", "d": []}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "CL:0000716", "l": "lymph gland crystal cell", "d": ["A crystal cell that derives from the larval lymph gland."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:1000308", "l": "fibrocyte of adventitia of ureter", "d": ["A fibrocyte that is part of the adventitia of ureter."]}]}
{"type": "biolink:Cell", "ic": "90.82444074280258", "identifiers": [{"i": "UMLS:C0225368", "l": "Chondroblasts", "d": []}, {"i": "NCIT:C32306", "l": "Chondroblast", "d": ["A cartilage-forming cell derived from a mesenchymal cell. The chondroblast secretes hyaluronidase, chondroitin sulfates, and collagen II to form a collagen matrix. It differentiates into a chondrocyte."]}, {"i": "SNOMEDCT:17512002", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002616", "l": "perirenal adipocyte", "d": ["A fat cell of perirenal fat tissue."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5177340", "l": "Pincer cells | Blood | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5172546", "l": "Metamyelocytes | Blood | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:2000088", "l": "Ammon's horn basket cell", "d": ["Any basket cell that is part of a Ammon's horn."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0000930", "l": "CD4-negative, CD8-negative type I NK T cell secreting interleukin-4", "d": ["A mature NK T cell that secretes interleukin-4 and enhances Th2 immune responses."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "MESH:D033661", "l": "Oocysts", "d": []}]}
{"type": "biolink:Cell", "ic": "82.076046914303362", "identifiers": [{"i": "UMLS:C1514181", "l": "Pleomorphic T-Lymphocyte", "d": []}, {"i": "NCIT:C36997", "l": "Pleomorphic T-Lymphocyte", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C3274464", "l": "Filgrastim-primed Peripheral Blood Progenitor Cells", "d": []}, {"i": "NCIT:C98836", "l": "Filgrastim-primed Peripheral Blood Progenitor Cells", "d": ["Peripheral blood progenitor cells (PBPC) primed with a recombinant form of the human granulocyte colony-stimulating factor (filgrastim). As a hematopoietic growth factor, filgrastim is able to mobilize hematopoietic progenitor cells (HPCs) into the peripheral blood which allows for an increased number of HPCs upon collection by leukapheresis. Administration of filgrastim-primed PBPCs following hematopoietic stem cell transplantation provides increased numbers of progenitor cells which may prevent pancytopenia and relapse."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5216290", "l": "Neutrophils|NCnc|Pt|Bld", "d": []}]}
{"type": "biolink:Cell", "ic": "78.435418415656045", "identifiers": [{"i": "CL:0000844", "l": "germinal center B cell", "d": ["A rapidly cycling mature B cell that has distinct phenotypic characteristics and is involved in T-dependent immune responses and located typically in the germinal centers of lymph nodes. This cell type expresses Ly77 after activation."]}]}
{"type": "biolink:Cell", "ic": "90.82444074280258", "identifiers": [{"i": "UMLS:C1513872", "l": "Naive Pregerminal Center B-Lymphocyte", "d": []}, {"i": "NCIT:C38337", "l": "Naive Pregerminal Center B-Lymphocyte", "d": ["A mature B lymphocyte that expresses IgM and IgD. It is found in peripheral blood, lymph nodes and secondary lymphoid organs, but has not moved into the germinal center of lymphoid organs. Once this cell encounters an antigen in the presence of helper T cells and becomes activated, it moves to the next stage of B-lymphocyte development."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0009039", "l": "colon goblet cell", "d": ["A goblet cell that is located in the colon."]}]}
{"type": "biolink:Cell", "ic": "66.450104551419699", "identifiers": [{"i": "UMLS:C0003315", "l": "Antigen-Presenting Cells", "d": []}, {"i": "NCIT:C12621", "l": "Antigen Presenting Cell", "d": ["A cell that enables a T-lymphocyte to recognize an antigen by engulfing the antigen, breaking down the antigen into smaller fragments which bind to MHC molecules on the surface of the antigen presenting cell. The T-lymphocyte can now recognize and bind with the MHC-linked antigen."]}, {"i": "MESH:D000938", "l": "Antigen-Presenting Cells", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5556653", "l": "Allogeneic Cytokine-induced Memory-like NK Cells WU-NK-101", "d": []}, {"i": "NCIT:C180829", "l": "Allogeneic Cytokine-induced Memory-like NK Cells WU-NK-101", "d": ["A population of off-the-shelf (OTS) donor-derived cytokine-induced, memory-like, cytotoxic natural killer (NK) cells (CIML NKs) containing NK cell-activating surface receptors, with potential immunomodulating and antineoplastic activities. The allogeneic NK cells are pre-activated ex vivo using the human-derived cytokines interleukin (IL)-12, IL-15, and IL-18, which induces the differentiation of the NK cells into CIML NK cells, which contain more NK cell-activating surface receptors. The pretreated NK cells exhibit enhanced activation and increased production of the cytokine interferon-gamma (IFN-g), and may exert enhanced cytotoxicity against tumor cells, including enhanced antibody-dependent cellular cytotoxicity (ADCC). Upon administration, the CIML NKs WU-NK-101 may induce an anti-tumor immune response and kill tumor cells."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0005007", "l": "Kolmer-Agduhr neuron", "d": ["Kolmer-Agduhr neurons are ciliated GABAergic neurons that contact the central canal of the spinal cord and have ipsilateral ascending axons."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0333852", "l": "Türk cell", "d": []}, {"i": "SNOMEDCT:4205002", "d": []}]}
{"type": "biolink:Cell", "ic": "54.660611541425112", "identifiers": [{"i": "CL:0000039", "l": "germ line cell", "d": ["A cell that is within the developmental lineage of gametes and is able to pass along its genetic material to offspring."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2338897", "l": "Paneth cell of epithelium of large intestine", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1512548", "l": "Hyperchromatic Endothelial Cell", "d": []}, {"i": "NCIT:C37089", "l": "Hyperchromatic Endothelial Cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0443779", "l": "Microspherocyte", "d": []}, {"i": "SNOMEDCT:259683003", "d": []}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "CL:0000569", "l": "cardiac mesenchymal cell", "d": ["A mesenchymal cell found in the developing heart and that develops into some part of the heart.  These cells derive from intra- and extra-cardiac sources, including the endocardium, epicardium, neural crest, and second heart field."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5185786", "l": "ZAP70 cells | Bone marrow | Cell markers", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C0333837", "l": "Gaucher cell", "d": []}, {"i": "NCIT:C36731", "l": "Gaucher Cell", "d": []}, {"i": "SNOMEDCT:16216007", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157335", "l": "CD16-CD57+ | White blood cells | Cell markers", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5216311", "l": "Polymorphonuclear cells|NCnc|Pt|Periton fld", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1267933", "l": "Lymphocyte positive for CD46 antigen", "d": []}, {"i": "SNOMEDCT:117376006", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:1000327", "l": "appendix goblet cell", "d": ["A goblet cell that is part of the epithelium proper of appendix."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C4055421", "l": "Autologous WT1-TCRc4 Gene-transduced CD8-positive Tcm/Tn Lymphocytes", "d": []}, {"i": "NCIT:C121308", "l": "Autologous WT1-TCRc4 Gene-transduced CD8-positive Tcm/Tn Lymphocytes", "d": ["Autologous, human CD8 T-lymphocytes, comprised of both central memory T-cells (Tcm) and naïve T-cells (Tn), that are transduced, ex vivo, with a self-inactivating (SIN) lentiviral vector encoding a high-affinity T-cell receptor (TCRc4) specific for the human tumor antigen Wilms tumor 1 (WT1) epitope 126-134 (RMFPNAPYL), with potential antineoplastic activity. Upon isolation of peripheral blood lymphocytes (PBLs), transduction, expansion ex vivo, priming of the Tn subset, but not the Tcm subset, with interleukin-21 (IL-21) and reintroduction of equal amounts of Tcm and Tn cells into the patient, WT1-TCRc4 gene-transduced CD8-positive Tcm/Tn lymphocytes redirect T-lymphocytes to WT1-expressing tumor cells and specifically bind to and lyse those cells. This inhibits proliferation of WT1-expressing tumor cells. WT1 protein, a zinc finger DNA-binding transcriptional regulator, is overexpressed in most leukemias and various solid tumors, while expression in normal, healthy tissues is very limited; its expression is correlated with aggressiveness and poor prognosis."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:4033040", "l": "lung resident memory CD8-positive, CD103-positive, alpha-beta T cell", "d": ["A lung resident memory CD8-positive, alpha-beta T cell that is CD103-positive."]}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "UMLS:C1709188", "l": "Neoplastic Ovoid Mononuclear Stromal Cell", "d": []}, {"i": "NCIT:C49053", "l": "Neoplastic Ovoid Mononuclear Stromal Cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2329800", "l": "Purkinje myocyte of atrioventricular bundle", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4038492", "l": "Cells.diploid.G1 phase", "d": []}]}
{"type": "biolink:Cell", "ic": "67.989777303936307", "identifiers": [{"i": "CL:0000576", "l": "monocyte", "d": ["Myeloid mononuclear recirculating leukocyte that can act as a precursor of tissue macrophages, osteoclasts and some populations of tissue dendritic cells."]}]}
{"type": "biolink:Cell", "ic": "70.517713470395833", "identifiers": [{"i": "CL:0000123", "l": "neuron associated cell (sensu Vertebrata)", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2736184", "l": "Cells.CD55+CD59", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002164", "l": "external pillar cell of cochlea", "d": ["A rod-shaped cell found in 3 or 4 rows that lie adjacent to and support the outer hair cells."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0009017", "l": "intestinal crypt stem cell of small intestine", "d": ["An intestinal stem cell that is located in the small intestine crypt of Liberkuhn. These stem cells reside at the bottom of crypts in the small intestine and are highly proliferative. They either differentiate into transit amplifying cells or self-renew to form new stem cells."]}]}
{"type": "biolink:Cell", "ic": "84.75972595860604", "identifiers": [{"i": "CL:1000155", "l": "Malpighian tubule stellate cell", "d": ["A specialized epithelial secretory cell that moves chloride ions and water across the tubule epithelium."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0000883", "l": "thymic cortical macrophage", "d": ["A thymic macrophage found in the thymic cortex."]}]}
{"type": "biolink:Cell", "ic": "62.945349939901874", "identifiers": [{"i": "CL:2000001", "l": "peripheral blood mononuclear cell", "d": ["A leukocyte with a single non-segmented nucleus in the mature form found in the circulatory pool of blood."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1440363", "l": "Cells.CD86", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002280", "l": "type N enteroendocrine cell", "d": ["An enteroendocrine cell found in the ileum and jejunum that produces neurotensin."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1440054", "l": "Abnormal blood cells.CD33", "d": []}]}
{"type": "biolink:Cell", "ic": "65.099244958558103", "identifiers": [{"i": "CL:0000164", "l": "enteroendocrine cell", "d": ["An endocrine cell that is located in the epithelium of the gastrointestinal tract or in the pancreas."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5382746", "l": "CD107a+b expressing HLA-A1 Cytomegalovirus specific CD8 cells | Blood | Cell markers", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0333810", "l": "Knizocyte", "d": []}, {"i": "SNOMEDCT:84082000", "d": []}]}
{"type": "biolink:Cell", "ic": "82.532694649739099", "identifiers": [{"i": "UMLS:C1882050", "l": "Neoplastic Epithelial Oval Cell", "d": []}, {"i": "NCIT:C60990", "l": "Neoplastic Epithelial Oval Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0009038", "l": "colon macrophage", "d": ["A macrophage that is located in the colon."]}]}
{"type": "biolink:Cell", "ic": "70.216808612803263", "identifiers": [{"i": "CL:4023016", "l": "vip GABAergic cortical interneuron", "d": ["A GABAergic neuron located in the cerebral cortex that expresses vasoactive intestinal polypeptide"]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5670722", "l": "Anti-CD19/CD20/CD22 CAR T-Cells", "d": []}, {"i": "NCIT:C186728", "l": "Anti-CD19/CD20/CD22 CAR T-Cells", "d": ["A preparation of human T-lymphocytes engineered to express a chimeric antigen receptor (CAR) specific for the tumor-associated antigens (TAAs) cluster of differentiation 19 (CD19), CD20 and CD22, with potential immunostimulating and antineoplastic activities. Upon administration, the anti-CD19/CD20/CD22 CAR-T cells target and bind to CD19, CD20 and CD22 expressed on the surface of certain tumor cells. This induces selective toxicity in tumor cells expressing these TAAs. The TAAs are overexpressed in certain hematologic malignancies."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5216250", "l": "Lymphocytes|NCnc|Pt|Body fld", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:1000367", "l": "transitional myocyte of posterior internodal tract", "d": ["A transitional myocyte that is part of the posterior internodal tract."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002640", "l": "amniotic epithelial stem cell", "d": ["An epithelial fate stem cell derived form the amnion membrane."]}]}
{"type": "biolink:Cell", "ic": "80.511444690059548", "identifiers": [{"i": "CL:0000896", "l": "activated CD4-positive, alpha-beta T cell", "d": ["A recently activated CD4-positive, alpha-beta T cell with the phenotype CD69-positive, CD62L-negative, CD127-negative, and CD25-positive."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5175149", "l": "Nucleated cells | Cerebral spinal fluid | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "ic": "92.728541327098611", "identifiers": [{"i": "CL:1001127", "l": "outer renal medulla vasa recta cell", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002011", "l": "Kit-positive macrophage dendritic cell progenitor", "d": ["A progenitor cell that can give rise to plasmacytoid and myeloid dendritic cells, and to monocytes and macrophages. Marker for this cell is Kit-high, CD115-positive, CD135-positive, Cx3cr1-positive, and is Il7ra-negative."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4697021", "l": "Cells.CD27+", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0010000", "l": "keratinized cell of hair follicle", "d": ["A hair follicle matrix region cell which synthesizes keratin and undergoes a characteristic change as it moves upward from the hair bulb to become the hair medulla cortex and hair root sheath."]}]}
{"type": "biolink:Cell", "ic": "89.347505587204751", "identifiers": [{"i": "UMLS:C1708893", "l": "Malignant Neuroectodermal Small Cell", "d": []}, {"i": "NCIT:C54044", "l": "Malignant Neuroectodermal Small Cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5426871", "l": "CD3+CD8+CD27+CD45RO+CD62L+ cells | Blood | Cell markers", "d": []}]}
{"type": "biolink:Cell", "ic": "77.712653754434029", "identifiers": [{"i": "CL:0019019", "l": "tracheobronchial smooth muscle cell", "d": ["A smooth muscle cell that is part of the tracheobronchial tree."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5427435", "l": "Xanthoma cells | Lower respiratory specimen | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157296", "l": "CD13 blasts | Bone marrow | Cell markers", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157599", "l": "CD5+CD20+ cells | White blood cells | Cell markers", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C3825563", "l": "Ultrastructure (Biology)", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4743545", "l": "Spanlecortemlocel", "d": []}]}
{"type": "biolink:Cell", "ic": "84.75972595860604", "identifiers": [{"i": "UMLS:C0225360", "l": "Myofibroblasts", "d": []}, {"i": "NCIT:C33153", "l": "Myofibroblast", "d": ["A spindle-shaped cell that exhibits characteristics of both fibroblasts and smooth muscle cells. It has an elongated nucleus and does not have basal lamina. The cytoplasm can be distinguished from the surrounding matrix because of actin filaments, myosin and other muscle proteins arranged to suggest a contractile ability."]}, {"i": "MESH:D058628", "l": "Myofibroblasts", "d": []}, {"i": "SNOMEDCT:56790003", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5175602", "l": "Other cells | Blood | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C3274553", "l": "Tri-virus/GD2-specific Allogeneic Cytotoxic T-lymphocytes", "d": []}, {"i": "NCIT:C99132", "l": "Tri-virus/GD2-specific Allogeneic Cytotoxic T-lymphocytes", "d": ["Allogeneic tri-viral specific, Epstein-Barr virus (EBV), cytomegalovirus (CMV) and adenovirus (Ad), cytotoxic T-lymphocytes (tV-CTLs) expressing a chimeric antigen receptor (CAR) specific for disialoganglioside GD2 with potential antineoplastic activity. Tri-virus/GD2-specific allogeneic CTLs are produced by transducing tV-CTLs with a GD2-specific CAR retroviral vector. Upon administration, after an allogeneic hematopoietic stem cell transplant, these CTLs may be selective towards EBV, CMV, and Ad-infected cells and GD2-expressing tumor cells. The human glycosphingolipid GD2 is a tumor associated antigen overexpressed on the surface of all tumors of neuroectodermal origin."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0009018", "l": "lymphocyte of large intestine lamina propria", "d": ["A lymphocyte that resides in the lamina propria of the large intestine."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5380991", "l": "Cells.CD8.HLA-A1 CMV specific.CMV antigen stimulated CD107a+b expressing", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1257739", "l": "NIH 3T3 Cells", "d": []}, {"i": "NCIT:C17422", "l": "NIH/3T3", "d": ["An immortalized fibroblast cell line derived from a mouse embryo in 1962 by George Todaro and Howard Green. These cells retain contact inhibition."]}, {"i": "MESH:D041681", "l": "NIH 3T3 Cells", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0684134", "l": "exciter neuron", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C3485979", "l": "Allogeneic Cells", "d": []}, {"i": "MESH:D000078422", "l": "Allogeneic Cells", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1267984", "l": "Lymphocyte positive for CD97 antigen", "d": []}, {"i": "SNOMEDCT:117424006", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002079", "l": "pancreatic ductal cell", "d": ["Epithelial cell found in the ducts of the pancreas. This cell type contributes to the high luminal pH."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5448035", "l": "Afamitresgene Autoleucel", "d": []}, {"i": "NCIT:C175738", "l": "Afamitresgene Autoleucel", "d": []}]}
{"type": "biolink:Cell", "ic": "90.82444074280258", "identifiers": [{"i": "CL:0002085", "l": "tanycyte", "d": ["Specialized elongated ventricular ependymal cell that has processes that extend to the outer, or pial, surface of the CNS. Resemble spongioblasts seen in developing brain. Found in the adult brain in the third ventricle, cerebral aqueduct, spinal canal and floor of the fourth ventricle."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1979202", "l": "Blast cell positive for CD3 antigen", "d": []}, {"i": "SNOMEDCT:724261003", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C4687588", "l": "NY-ESO-1 TCR/sr39TK Lentiviral Vector-transduced Autologous PBSCs", "d": []}, {"i": "NCIT:C146940", "l": "NY-ESO-1 TCR/sr39TK Lentiviral Vector-transduced Autologous PBSCs", "d": ["Human autologous peripheral blood stem cells (PBSCs) transduced with a lentiviral vector (LV) encoding a T-cell receptor (TCR) specific for the cancer-testis antigen NY-ESO-1, and carrying the positron emission tomography (PET) reporter/suicide gene sr39TK, a mutant form of the herpes simplex virus type 1 thymidine kinase gene (HSV-1 TK), with potential immunostimulating and antineoplastic activities. Upon isolation, transduction, expansion ex vivo, and reintroduction into the patient, the NY-ESO-1 TCR/sr39TK LV-transduced autologous PBSCs recognize and bind to NY-ESO-1-overexpressing tumor cells. This may result in a specific cytotoxic T-lymphocyte (CTL)-mediated killing of NY-ESO-1-positive tumor cells. NY-ESO-1, a tumor-associated antigen (TAA), is found in normal testis and on the surface of various tumor cell types. The incorporation of sr39TK allows for the ganciclovir (GCV)-mediated cell killing of the gene-modified PBSCs if serious adverse effects occur. sr39TK converts the nucleoside prodrug GCV into GCV monophosphate (GCV-MP), which is in turn phosphorylated by cellular kinases to the cytotoxic nucleotide GCV-triphosphate (GCV-TP); the TP form competitively inhibits deoxyguanosine triphosphate (dGTP) incorporation into DNA and inhibits DNA synthesis, causing DNA damage and cell death in the sr39TK-expressing PBSCs. In addition, sr39TK allows for PET imaging of the gene-modified PBSCs upon subsequent administration of radio-labeled substrates, such as 9-(4-[18F]-fluoro-3-[hydroxymethyl]butyl)guanine ([18F]-FHBG). The monophosphorylation of [18 F]-FHBG is catalyzed by sr39TK; this promotes triphosphorylation and accumulation of [18F]-FHBG in the PBSCs, which allows in vivo imaging and tracking of the PBSCs upon PET. Compared to wild-type HSV-TK, the mutant form has increased prodrug phosphorylating capacity and enhances the cell killing by GCV."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C4727097", "l": "Autologous TCR-engineered T-cells IMA202", "d": []}, {"i": "NCIT:C153218", "l": "Autologous TCR-engineered T-cells IMA202", "d": ["A preparation of autologous T-lymphocytes that are genetically modified with a lentiviral vector encoding a T-cell receptor (TCR) targeting patient-specific tumor associated antigens (TAAs), with potential antineoplastic activity. Upon intravenous administration back into the patient, the autologous TCR-engineered T-cells IMA202 specifically recognize and bind to the TAA on cancer cells, which induces a cytotoxic T-lymphocyte (CTL)-mediated immune response against the TAA-positive cancer cells."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1183184", "l": "Set of aminergic cells in ventral tegmental area [A10]", "d": []}]}
{"type": "biolink:Cell", "ic": "79.849015605436421", "identifiers": [{"i": "CL:0000449", "l": "brown fat cell", "d": ["A cell from the thermogenic form of adipose tissue found in many species,  particularly in newborns and hibernating mammals, but also in lesser amounts in adults of other mammals including humans. Brown fat is capable of rapid liberation of energy and seems to be important in the maintenance of body temperature immediately after birth and upon waking from hibernation."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1184798", "l": "Supporting cell of vestibular epithelium", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5179522", "l": "Reticulocytes.high light scatter | Blood | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1440402", "l": "Cells.t(11;22)(p13;q12.2)(WT1,EWSR1)", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1955380", "l": "Spermatozoa structure", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1518217", "l": "Malignant Neuroendocrine Cell with Abundant Cytoplasm", "d": []}, {"i": "NCIT:C36917", "l": "Malignant Neuroendocrine Cell with Abundant Cytoplasm", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1267960", "l": "Lymphocyte positive for CD66C antigen", "d": []}, {"i": "SNOMEDCT:117401004", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1179491", "l": "Epithelial cell of Malassez", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1179829", "l": "Epithelial cell of tracheobronchial tree", "d": []}]}
{"type": "biolink:Cell", "ic": "87.120474278337809", "identifiers": [{"i": "CL:0000834", "l": "neutrophil progenitor cell", "d": ["A progenitor cell of the neutrophil lineage."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002226", "l": "non-nucleated secondary lens fiber", "d": ["A secondary lens fiber cell that lacks a nucleus."]}]}
{"type": "biolink:Cell", "ic": "89.347505587204751", "identifiers": [{"i": "CL:0002575", "l": "central nervous system pericyte", "d": ["A pericyte of the central nervous system."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2334011", "l": "Wandering histiocyte", "d": []}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "CL:0002524", "l": "disseminated nephrocyte", "d": ["A disseminated nephrocyte is a nephrocyte that filters hemolymph and is found at scattered locations in the fat body or other tissues."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5551406", "l": "relmacabtagene autoleucel", "d": []}, {"i": "MESH:C000718412", "l": "relmacabtagene autoleucel", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5706393", "l": "Allogeneic iPSC-derived Anti-CD19-CAR/IL-15-expressing NK Cells CNTY-101", "d": []}, {"i": "NCIT:C187301", "l": "Allogeneic iPSC-derived Anti-CD19-CAR/IL-15-expressing NK Cells CNTY-101", "d": ["A preparation of allogeneic natural killer (NK) cells derived from a clonal master induced pluripotent stem cell (iPSC) line, and engineered to express a chimeric antigen receptor (CAR) consisting of an anti-CD19 single chain variable fragment (scFv) derived from the anti-CD19 monoclonal antibody FMC63 and coupled to the CD28 and zeta chain of the TCR/CD3 complex (CD3-zeta) costimulatory signaling domains, and interleukin 15 (IL-15), with potential immunostimulatory and antineoplastic activities. Upon administration, allogeneic iPSC-derived anti-CD19-CAR/IL-15-expressing NK cells CNTY-101 recognize, bind to and induce selective cytotoxicity in CD19-expressing tumor cells. IL-15 is a pro-survival cytokine that promotes T-cell persistence and potentiates the immune response against tumor cells. The human tumor associated antigen (TAA) CD19 is a B-cell specific cell surface antigen expressed in all B-cell lineage malignancies. CNTY-101 is also engineered with a safety switch composed of a shorter version of the extracellular domain of human epidermal growth factor receptor (EGFR). This allows the elimination of CNTY-101 upon the administration of anti-EGFR antibodies such as cetuximab. In addition, CNTY-101 is gene-edited to prevent its elimination by the patient's NK cells, CD4 and CD8 T-cells."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2333349", "l": "Retinal microglial cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157284", "l": "CD123 blasts | XXX | Cell markers", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1267942", "l": "Lymphocyte positive for CD50 antigen", "d": []}, {"i": "SNOMEDCT:117385006", "d": []}]}
{"type": "biolink:Cell", "ic": "74.659114980698789", "identifiers": [{"i": "CL:0000390", "l": "blood cell (sensu Nematoda and Protostomia)", "d": []}]}
{"type": "biolink:Cell", "ic": "85.457082654197222", "identifiers": [{"i": "CL:0000795", "l": "CD8-positive, alpha-beta regulatory T cell", "d": ["A CD8-positive, alpha-beta T cell that regulates overall immune responses as well as the responses of other T cell subsets through direct cell-cell contact and cytokine release."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5185787", "l": "ZAP70 cells | XXX | Cell markers", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1977364", "l": "Granulocytes.CD55", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C4086897", "l": "Tergenpumatucel-L", "d": []}, {"i": "NCIT:C66985", "l": "Tergenpumatucel-L", "d": ["An allogeneic lung cancer vaccine with potential immunostimulating and antineoplastic activities. Derived from allogeneic lung tumor cells, tergenpumatucel-L is engineered to express the murine alpha-1,3-galactosyltransferase (GalT), an enzyme humans lack. GalT catalyzes the expression of foreign alpha-1,3-galactosyl (alpha-gal) carbohydrate epitopes in glycoproteins and in glycolipids on the cell membranes of the allogeneic lung tumor cells present in the vaccine, essentially producing a 'xenograft'. The hyperacute rejection involves pre-existing human anti-alpha-gal antibodies that bind the foreign alpha-gal epitopes expressed by the vaccine tumor cell xenograft, resulting in complement-mediated cytotoxicity (CMC) and antibody-dependent cell-mediated cytotoxicity (ADCC) towards endogenous lung tumor cells with unmodified carbohydrate epitopes."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5420487", "l": "TM4SF1-CAR/EpCAM-CAR-expressing Autologous T Cells", "d": []}, {"i": "NCIT:C173965", "l": "TM4SF1-CAR/EpCAM-CAR-expressing Autologous T Cells", "d": ["A mixed preparation of allogeneic T-lymphocytes that have been genetically modified to express either a chimeric antigen receptor (CAR) specific for the antigen transmembrane 4 L six family member 1 (TM4SF1) (CART-TM4SF1) or a CAR specific for epithelial cell adhesion molecule (EpCAM) (CART-EpCAM), with potential immunostimulating and antineoplastic activities. Upon administration of the TM4SF1-CAR/EpCAM-CAR-expressing autologous T cells, the TM4SF1-CAR-expressing autologous T-cells specifically recognize and bind to TM4SF1-expressing tumor cells and the EpCAM-CAR-expressing autologous T-cells specifically recognize and bind to EpCAM-expressing tumor cells, resulting in tumor cell lysis. TM4SF1 and EpCAM are expressed by a variety of tumor cells."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1182778", "l": "Epithelial cell of sweat gland", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C2347257", "l": "CD3/CD28 Costimulated Autologous T-Cells", "d": []}, {"i": "NCIT:C74017", "l": "CD3/CD28 Costimulated Autologous T-Cells", "d": ["A population of T cells that have been sensitized to vaccine tumor antigen(s) in vivo; collected from the patient; co-stimulated with antibodies to the T-cell cell surface proteins CD3 and CD28 and expanded ex vivo; and then infused into the same patient. CD3, part of the T cell receptor complex, and CD28, a T-cell surface-associated co-stimulatory molecule, are both required for full T-cell activation. Adoptive transfer of CD3/CD28 costimulated vaccine-primed autologous T-cells may induce the production of interferon-gamma (IFN-gamma) and granulocyte-macrophage colony-stimulating factor (GM-CSF) and associated antitumor effects and a graft-versus-tumor (GVT) response."]}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "UMLS:C1514085", "l": "Neoplastic Small Cell", "d": []}, {"i": "NCIT:C37103", "l": "Neoplastic Small Cell", "d": ["A benign or malignant cell that is characterized by the presence of a small nucleus and scant amount of cytoplasm.  It may be epithelial, lymphoid, neuroepithelial, or mesenchymal in origin."]}]}
{"type": "biolink:Cell", "ic": "82.076046914303362", "identifiers": [{"i": "CL:0000158", "l": "club cell", "d": ["A non-mucous, epithelial secretory cell that is part of the tracheobronchial tree. A club cell has short microvilli but no cilia. A club cell is able to multiply and differentiate into ciliated cells to regenerate the bronchiolar epithelium and it also protects the tracheobronchial epithelium."]}]}
{"type": "biolink:Cell", "ic": "92.728541327098611", "identifiers": [{"i": "CL:4030019", "l": "kidney connecting tubule intercalated cell", "d": ["A renal intercalated cell that is part of the renal connecting tubule."]}]}
{"type": "biolink:Cell", "ic": "78.185623981295834", "identifiers": [{"i": "UMLS:C1879883", "l": "Blastemal Cell", "d": []}, {"i": "NCIT:C61288", "l": "Blastemal Cell", "d": ["An embryonic undifferentiated cell that can grow and differentiate into organs or body parts."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5170919", "l": "Leukocytes | Blood product unit | Blood | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "ic": "92.728541327098611", "identifiers": [{"i": "UMLS:C1881554", "l": "Malignant Giant Germ Cell", "d": []}, {"i": "NCIT:C61385", "l": "Malignant Giant Germ Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002389", "l": "uninucleate arthroconidium", "d": ["An arthroconidium that has only one nucleus."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5401666", "l": "BREXUCABTAGENE", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:2000040", "l": "bladder microvascular endothelial cell", "d": ["Any microvascular endothelial cell that is part of a urinary bladder."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4706671", "l": "Genetically modified T-cell", "d": []}, {"i": "SNOMEDCT:764084004", "d": []}, {"i": "SNOMEDCT:764087006", "d": []}]}
{"type": "biolink:Cell", "ic": "84.128890093485552", "identifiers": [{"i": "UMLS:C1517724", "l": "Large Atypical Platelet", "d": []}, {"i": "NCIT:C37039", "l": "Large Atypical Platelet", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2326979", "l": "Diffuse amacrine cell of retina", "d": []}]}
{"type": "biolink:Cell", "ic": "90.82444074280258", "identifiers": [{"i": "UMLS:C1514017", "l": "CD4+/CD56+ Neoplastic Medium-Sized Cell", "d": []}, {"i": "NCIT:C39301", "l": "CD4+/CD56+ Neoplastic Medium-Sized Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "89.347505587204751", "identifiers": [{"i": "CL:0001054", "l": "CD14-positive monocyte", "d": ["A monocyte that expresses CD14 and is negative for the lineage markers CD3, CD19, and CD20."]}]}
{"type": "biolink:Cell", "ic": "85.457082654197222", "identifiers": [{"i": "UMLS:C0037868", "l": "sperm cell", "d": []}, {"i": "NCIT:C12602", "l": "Spermatozoon", "d": ["The male reproductive cell that is formed in the testicle. A sperm consists of a head, a body, and a tail that provides propulsion."]}, {"i": "MESH:D013094", "l": "Spermatozoa", "d": []}, {"i": "SNOMEDCT:6789008", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1269647", "l": "Entire cell", "d": []}, {"i": "SNOMEDCT:362837007", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0814995", "l": "Skin cell", "d": []}, {"i": "SNOMEDCT:314819008", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5575455", "l": "Autologous Anti-GPC3 CAR-IL-15-iCasp9-expressing T-lymphocytes", "d": []}, {"i": "NCIT:C185429", "l": "Autologous Interleukin-15-armored Anti-glypican-3 CAR-iC9-expressing T-lymphocytes", "d": ["A preparation of T-lymphocytes that have been genetically modified to express a chimeric antigen receptor (CAR) specific for glypican-3 (GPC3) and express interleukin-15 (IL-15) and the suicide gene, inducible caspase 9 (iCasp9 or iC9), with potential immunostimulating and antineoplastic activities. Upon administration, autologous IL-15-armored anti-GPC3 CAR-iC9-expressing T-lymphocytes specifically target and bind to GPC3-expressing tumor cells, resulting in tumor cell lysis. GPC3, a heparan sulfate proteoglycan and a member of the glypican family, is overexpressed on certain tumor cell types while minimally expressed on normal, healthy cells; GPC3 plays an important role in cellular proliferation and differentiation. IL-15 is a pro-survival cytokine that potentiates, in addition to promoting T-cell proliferation and persistence, the immune response against tumor cells. The iCasp9 safety switch consists of a full-length caspase 9, including its caspase recruitment domain, linked to a human FK506 drug-binding domain with an F36V mutation (FKBP12-F36V). If the administered CAR T-cells lead to unacceptable side effects, the chemical homodimerizer AP1903 can be administered. AP1903 binds to the FKBP12-F36V drug-binding domain, activates caspase 9 and results in apoptosis of the administered CAR T-cells."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157925", "l": "Cells | Right anterior chamber | NEI eyeGENE slit lamp biomicroscopy", "d": []}]}
{"type": "biolink:Cell", "ic": "92.728541327098611", "identifiers": [{"i": "CL:0000380", "l": "thecogen cell", "d": ["The support cell that makes the thecogen dendritic cap - a cuticle-like matrix around the tip of the eo-dendrite and which encloses the soma of the eo-neuron."]}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "CL:1000001", "l": "retrotrapezoid nucleus neuron", "d": []}]}
{"type": "biolink:Cell", "ic": "69.858950277264299", "identifiers": [{"i": "CL:0009001", "l": "compound eye retinal cell", "d": ["Any cell in the compound eye, a light sensing organ composed of ommatidia."]}]}
{"type": "biolink:Cell", "ic": "83.023198044254755", "identifiers": [{"i": "UMLS:C1711354", "l": "Malignant Mesenchymal Spindle Cell", "d": []}, {"i": "NCIT:C49056", "l": "Malignant Mesenchymal Spindle Cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C3261871", "l": "Circulating tumor cells.prostate", "d": []}]}
{"type": "biolink:Cell", "ic": "74.516770421031836", "identifiers": [{"i": "UMLS:C1517659", "l": "Keratinizing Malignant Squamous Cell", "d": []}, {"i": "NCIT:C36791", "l": "Keratinizing Malignant Squamous Cell", "d": ["A malignant squamous cell which produces extracellular keratin."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0000854", "l": "interneuromast cell", "d": ["Interneuromast cell is a neuroectodermal cell deposited by the migrating lateral line primordium between the neuromasts. Interneuromast cells proliferate and migrate to form additional neuromasts."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157506", "l": "CD36 blasts | XXX | Cell markers", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4037921", "l": "Cells.CD8+CD3-", "d": []}]}
{"type": "biolink:Cell", "ic": "42.505430161956824", "identifiers": [{"i": "UMLS:C1514033", "l": "Neoplastic Muscle Cell", "d": []}, {"i": "NCIT:C36936", "l": "Neoplastic Muscle Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C3899815", "l": "CD30 CAR-expressing Autologous T Lymphocytes", "d": []}, {"i": "NCIT:C116738", "l": "CD30 CAR-expressing Autologous T Lymphocytes", "d": ["A preparation of autologous T-lymphocytes that have been genetically modified to express a chimeric antigen receptor (CAR) specific for the CD30 antigen, with potential immunostimulating and antineoplastic activities. Upon administration, the CD30 CAR-expressing autologous T-lymphocytes specifically recognize and bind to CD30-expressing tumor cells, resulting in tumor cell lysis. CD30, a cell surface receptor and a member of the tumor necrosis factor (TNF) receptor superfamily, is transiently expressed on activated lymphocytes and is constitutively expressed in hematologic malignancies."]}]}
{"type": "biolink:Cell", "ic": "77.712653754434029", "identifiers": [{"i": "CL:0000767", "l": "basophil", "d": ["Any of the immature or mature forms of a granular leukocyte that in its mature form has an irregularly shaped, pale-staining nucleus that is partially constricted into two lobes, and with cytoplasm that contains coarse, bluish-black granules of variable size. Basophils contain vasoactive amines such as histamine and serotonin, which are released on appropriate stimulation. A basophil is CD123-positive, CD193-positive, CD203c-positive, and FceRIa-positive."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1441017", "l": "Neutrophil cytoplasmic", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1955384", "l": "Spermatozoa.isolated tail", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5706522", "l": "Autologous Anti-PRAME TCR/CD8alphabeta-expressing T-cells IMA203CD8", "d": []}, {"i": "NCIT:C188985", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1440261", "l": "Cells.CD16-CD34+", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:4032001", "l": "reelin GABAergic cortical interneuron", "d": ["A GABAergic interneuron located in the cerebral cortex that expresses reelin (rln)."]}]}
{"type": "biolink:Cell", "ic": "90.82444074280258", "identifiers": [{"i": "CL:0001056", "l": "dendritic cell, human", "d": ["A dendritic cell with the phenotype HLA-DRA-positive."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5572250", "l": "Epithelial cells | Bronchoalveolar lavage | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "ic": "48.188040833303326", "identifiers": [{"i": "UMLS:C1510734", "l": "Abnormal Squamous Cell", "d": []}, {"i": "NCIT:C36772", "l": "Abnormal Squamous Cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1257751", "l": "Erythroid Cells", "d": []}, {"i": "MESH:D041905", "l": "Erythroid Cells", "d": []}, {"i": "SNOMEDCT:414128005", "d": []}]}
{"type": "biolink:Cell", "ic": "90.82444074280258", "identifiers": [{"i": "CL:1000412", "l": "endothelial cell of arteriole", "d": ["An endothelial cell that is part of the arteriole."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2326580", "l": "Type A enteroendocrine cell", "d": []}]}
{"type": "biolink:Cell", "ic": "34.889948927490963", "identifiers": [{"i": "CL:0000393", "l": "electrically responsive cell", "d": ["A cell whose function is determined by its response to an electric signal."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1882409", "l": "Pluripotent Bronchial Precursor Cell", "d": []}, {"i": "NCIT:C55819", "l": "Pluripotent Bronchial Precursor Cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0599409", "l": "sensory transducer cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0599415", "l": "Spodoptera frugiperda cell line", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0004246", "l": "monostratified cell", "d": ["A central nervous system neuron that stratifies at one and only one location."]}]}
{"type": "biolink:Cell", "ic": "83.023198044254755", "identifiers": [{"i": "CL:0007010", "l": "preosteoblast", "d": ["Skeletogenic cell that has the potential to transform into an osteoblast, and develops from neural crest or mesodermal cells."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:2000067", "l": "cardiac atrium fibroblast", "d": ["Any fibroblast that is part of a cardiac atrium."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5666887", "l": "Autologous HIV Gag-specific CD4+ T-cells AGT103-T", "d": []}, {"i": "NCIT:C182458", "l": "Autologous HIV Gag-specific CD4+ T-cells AGT103-T", "d": ["A preparation of autologous, human immunodeficiency virus (HIV) Gag-specific, cluster of differentiation 4 (CD4)-positive T-lymphocytes, with potential antiviral activity. Autologous HIV Gag-specific CD4+ T-cells AGT103-T are prepared via ex vivo stimulation of autologous peripheral blood mononuclear cells (PBMCs) with Gag peptides, and the Gag-specific CD4+ T-cells are transduced with the recombinant lentiviral vector AGT103 encoding inhibitory RNA targeting the HIV coreceptor C-C chemokine receptor type 5 (CCR5) and HIV sequences within the Vif/Tat coding regions. Upon administration, autologous HIV Gag-specific CD4+ T-cells AGT103-T may prevent infection by CCR5- or CXCR4-tropic strains of HIV, reduce the depletion of CD4+ T-cells upon HIV exposure and prevent latently-infected cells from releasing new HIV particles."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5380997", "l": "Cells.CD8.HLA-A1 CMV specific.CMV antigen stimulated gamma interferon producing", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157562", "l": "CD41 cells | Blood | Cell markers", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002440", "l": "Ly49D-positive natural killer cell, mouse", "d": ["A NK1.1-positive T cell that is Ly49D-positive."]}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "CL:0002639", "l": "amniotic stem cell", "d": ["An amniotic stem cell is a mesenchymalstem cell extracted from amniotic fluid. Amniotic stem cells are able to differentiate into various tissue type such as skin, cartilage, cardiac tissue, nerves, muscle, and bone"]}]}
{"type": "biolink:Cell", "ic": "89.347505587204751", "identifiers": [{"i": "UMLS:C1709208", "l": "Neoplastic Thyroid Gland Follicular Clear Cell", "d": []}, {"i": "NCIT:C47832", "l": "Neoplastic Thyroid Gland Follicular Clear Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "84.75972595860604", "identifiers": [{"i": "CL:0002046", "l": "early pro-B cell", "d": ["A pro-B cell that is CD22-positive, CD34-positive, CD38-positive and TdT-positive (has TdT activity). Pre-BCR is expressed on the cell surface. Cell is CD19-negative, CD20-negative, complement receptor type 2-negative and CD10-low. D-to-J recombination of the heavy chain occurs at this stage."]}]}
{"type": "biolink:Cell", "ic": "64.931672288613356", "identifiers": [{"i": "UMLS:C1709175", "l": "Neoplastic Fibroblast", "d": []}, {"i": "NCIT:C48682", "l": "Neoplastic Fibroblast", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002661", "l": "luminal cell of lactiferous terminal ductal lobular unit", "d": ["A luminal cell of terminal ducts, i.e.e the terminal branch of a lactiferous duct which alveolar cells drain into."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5186845", "l": "Neutrophils | Control | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "ic": "92.728541327098611", "identifiers": [{"i": "CL:0000308", "l": "metal ion accumulating cell", "d": []}]}
{"type": "biolink:Cell", "ic": "92.728541327098611", "identifiers": [{"i": "CL:0011104", "l": "interplexiform cell", "d": ["A type of interneuron in the retinal inner nuclear layer which"]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:4023077", "l": "bitufted neuron", "d": ["A type of interneuron that has two clusters of dendritic branches that originate directly from the soma and extend in opposite directions and axons that form a plexus which spreads widely. Compared to bipolar neurons, bitufted neurons have branching that occur close to the soma."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0333720", "l": "Glycogenic cell", "d": []}, {"i": "SNOMEDCT:58726005", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0000560", "l": "band form neutrophil", "d": ["A late neutrophilic metamyelocyte in which the nucleus is indented to more than half the distance to the farthest nuclear margin but in no area being condensed to a single filament. The nucleus is in the form of a curved or coiled band, not having acquired the typical multilobar shape of the mature neutrophil. These cells are fMLP receptor-positive, CD11b-positive, CD35-negative, and CD49d-negative."]}]}
{"type": "biolink:Cell", "ic": "80.511444690059548", "identifiers": [{"i": "CL:4023054", "l": "mesothelial fibroblast", "d": ["A mesothelial cell that has undergone mesothelial-to-mesenchymal transition (MMT) to become a fibroblast cell."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5577049", "l": "Carvykti", "d": []}]}
{"type": "biolink:Cell", "ic": "78.96520244130248", "identifiers": [{"i": "UMLS:C1879555", "l": "Adenocarcinoma Cell with Eosinophilic Cytoplasm", "d": []}, {"i": "NCIT:C61145", "l": "Adenocarcinoma Cell with Eosinophilic Cytoplasm", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1440308", "l": "Cells.CD42a", "d": []}]}
{"type": "biolink:Cell", "ic": "60.614083926907639", "identifiers": [{"i": "UMLS:C1513713", "l": "Adenocarcinoma Cell with Intracytoplasmic Mucin", "d": []}, {"i": "NCIT:C37117", "l": "Adenocarcinoma Cell with Intracytoplasmic Mucin", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0009035", "l": "stromal cell of lamina propria of vermiform appendix", "d": ["A stromal cell found in the lamina propria of the vermiform appendix."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2330808", "l": "Mammosomatotroph", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:2000025", "l": "spinal cord oligodendrocyte", "d": ["Any oligodendrocyte that is part of a spinal cord."]}]}
{"type": "biolink:Cell", "ic": "71.88020023694385", "identifiers": [{"i": "UMLS:C1513967", "l": "Neoplastic Fibrohistiocytic Cell", "d": []}, {"i": "NCIT:C36962", "l": "Neoplastic Fibrohistiocytic Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "CL:1001217", "l": "interlobulary artery smooth muscle cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5161796", "l": "Cytoplasmic CD179a blasts | Bone marrow | Cell markers", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1515627", "l": "gp100-Reactive Autologous Tumor Infiltrating Lymphocyte", "d": []}, {"i": "NCIT:C38125", "l": "gp100-Reactive Autologous Tumor Infiltrating Lymphocyte", "d": ["Tumor infiltrating lymphocytes (TIL) isolated from a patient, exposed to the tumor-associated antigen gp100 in vitro, and then transferred back to the same patient to target tumor cells expressing gp100. gp100 human antigen is a wild-type self-antigen expressed by melanocytes, pigmented retinal cells and most melanomas. (NCI04)"]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5180942", "l": "Siderocytes per HPF | Blood | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5447676", "l": "Therapeutic Effector T-Lymphocytes", "d": []}, {"i": "NCIT:C177284", "l": "Therapeutic Effector T-Lymphocytes", "d": ["A preparation of autologous or donor-derived T-lymphocytes that is able to mount an antigen-specific immune response."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002234", "l": "basal cell of prostatic acinus", "d": ["A cell of the basal layer of the epithelium in the prostatic acinus."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5174616", "l": "Neutrophils | Control | Blood | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157461", "l": "CD3+CD8+CD28+HLA DR+ cells | Blood | Cell markers", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2324262", "l": "Secondary afferent neuron", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2736928", "l": "CD154+ cell", "d": []}, {"i": "SNOMEDCT:732273005", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C3642149", "l": "Rivogenlecleucel", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:2000041", "l": "dermis microvascular lymphatic vessel endothelial cell", "d": ["Any dermis lymphatic vessel endothelial cell that is part of a microvascular endothelium."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0009058", "l": "enterocyte of anorectum", "d": ["An enterocyte that is located in the anorectum."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C3896803", "l": "NK-92 cells", "d": []}, {"i": "NCIT:C117231", "l": "Allogeneic Natural Killer Cell Line NK-92", "d": ["A proprietary, human cytotoxic cell line composed of allogeneic, activated, interleukin-2 (IL-2) dependent-natural killer cells derived from a 50-year old male patient with rapidly progressive non-Hodgkin's lymphoma, with potential antineoplastic activity. As NK-92 cells are devoid of killer inhibitory receptors (KIRs; also called killer cell immunoglobulin-like receptors), which are negative regulators of NK cell activity, cancer cells are unable to suppress the cancer cell killing ability of the NK-92 cells. Upon infusion of the allogeneic NK cell line NK-92, the NKs recognize and bind to tumor cells. This leads to the secretion and release of perforins, granzymes, cytokines and chemokines, which results in cancer cell lysis and apoptosis. In addition, NK-92 cells express high affinity Fc receptors, which bind to therapeutic antibodies; therefore, this agent can enhance antibody dependent cellular cytotoxicity (ADCC) of co-administered therapeutic antibodies."]}]}
{"type": "biolink:Cell", "ic": "66.880045726402614", "identifiers": [{"i": "UMLS:C1518220", "l": "Malignant Neuroendocrine Large Cell", "d": []}, {"i": "NCIT:C36821", "l": "Malignant Neuroendocrine Large Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C3178844", "l": "Mesenchymal Stromal Cells", "d": []}, {"i": "NCIT:C179841", "l": "Mesenchymal Stromal Cell", "d": ["A heterogeneous, non-hematopoietic fibroblast-like cell with the potential for differentiating into connective tissue cells of multiple lineages.  It plays a significant role in tissue repair and regeneration, and interacts with immune cells to downregulate the immune response and enable immunosuppression via the induction of tolerance."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2325557", "l": "Serous cell of epithelium of lobular bronchiole", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1518624", "l": "Mouse Osteoblast", "d": []}, {"i": "NCIT:C22680", "l": "Mouse Osteoblast", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C3898205", "l": "NGFR-transduced Autologous T Lymphocytes", "d": []}, {"i": "NCIT:C118576", "l": "NGFR-transduced Autologous T Lymphocytes", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0229647", "l": "Basophilic metamyelocyte", "d": []}, {"i": "SNOMEDCT:63369000", "d": []}]}
{"type": "biolink:Cell", "ic": "73.011730055819953", "identifiers": [{"i": "UMLS:C1512901", "l": "Interstitial Cells of Cajal", "d": []}, {"i": "NCIT:C32871", "l": "Interstitial Cell of Cajal", "d": ["A specialized cell found throughout the gastrointestinal tract. These cells are essential for normal gastrointestinal motility by functioning as the pacemaker cells in gastrointestinal muscles. They mediate or transduce inputs from enteric motor nerves to the smooth muscle syncytium."]}, {"i": "MESH:D056885", "l": "Interstitial Cells of Cajal", "d": []}, {"i": "SNOMEDCT:1156991003", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1517359", "l": "GE92", "d": []}, {"i": "NCIT:C20262", "l": "GE92", "d": ["Provider: Geron Corporation, Menlo Park, CA. No information from provider. This cell line meets the criteria for the use of human embryonic stem cells by federally funded researchers."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5163546", "l": "Epithelial cells.ciliated | Body fluid | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0008033", "l": "decidual pericyte", "d": ["A pericyte of the decidual vasculature."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157376", "l": "CD2+CD7+ cells | Blood | Cell markers", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157357", "l": "CD19+CD38+IgM- cells | Blood | Cell markers", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5170931", "l": "Leukocytes | Gastric fluid | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5777122", "l": "Neoantigen specific TCR-T cell therapy", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1440384", "l": "Cells.euploid+Cells.aneuploid", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5554940", "l": "Autologous Spermatogonial Stem Cells", "d": []}, {"i": "NCIT:C178314", "l": "Autologous Spermatogonial Stem Cells", "d": ["A preparation of autologous spermatogonial stem cells (SSCs), that can potentially be used for intratesticular transplantation purposes. Upon injection into the testis, the autologous SCCs may recolonize and induce spermatogenesis, leading to mature spermatozoa, and thereby restoring fertility."]}]}
{"type": "biolink:Cell", "ic": "89.347505587204751", "identifiers": [{"i": "CL:1000453", "l": "epithelial cell of intermediate tubule", "d": ["An epithelial cell that is part of the intermediate tubule."]}]}
{"type": "biolink:Cell", "ic": "92.728541327098611", "identifiers": [{"i": "CL:0002386", "l": "multinucleate macroconidium", "d": ["A macroconidium that has more than one nucleus."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0282549", "l": "HL-60 Cells", "d": []}, {"i": "MESH:D018922", "l": "HL-60 Cells", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:1000287", "l": "myocyte of anterior internodal tract", "d": ["A muscle cell that is part of the anterior internodal tract."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1440414", "l": "Cells.t(8;14)(q24;q32)(MYC,IGH)", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0882932", "l": "Cells.CD8+CD28+", "d": []}]}
{"type": "biolink:Cell", "ic": "87.120474278337809", "identifiers": [{"i": "UMLS:C1513471", "l": "Monolobed Megakaryocyte", "d": []}, {"i": "NCIT:C37048", "l": "Monolobed Megakaryocyte", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C4330725", "l": "Myelodysplastic Syndrome Clone", "d": []}, {"i": "NCIT:C130199", "l": "Myelodysplastic Syndrome Clone", "d": ["A clonal population of dysplastic hematopoietic cells found in a patient with myelodysplastic syndrome."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157338", "l": "CD179a blasts | XXX | Cell markers", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0009057", "l": "anorectum goblet cell", "d": ["A goblet cell that is located in the anorectum."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5380986", "l": "Cells.CD8.CMV specific.CMV antigen stimulated CD107a+b expressing", "d": []}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "CL:0002091", "l": "primary polar body", "d": ["A small cell formed by the first meiotic division of oocytes."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157613", "l": "CD55 RBC | Blood | Cell markers", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2336824", "l": "Type 2 vestibular sensory cell of epithelium of macula of utricle of membranous labyrinth", "d": []}]}
{"type": "biolink:Cell", "ic": "61.11520282797931", "identifiers": [{"i": "CL:0010011", "l": "cerebral cortex GABAergic interneuron", "d": ["A GABAergic interneuron whose soma is located in the cerebral cortex."]}]}
{"type": "biolink:Cell", "ic": "87.120474278337809", "identifiers": [{"i": "CL:0000881", "l": "perivascular macrophage", "d": ["A central nervous system macrophage found in small blood vessels in the brain. Markers include CD14+CD16+CD163+."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1522253", "l": "Ovary - Lutein Cell (MMHCC)", "d": []}, {"i": "NCIT:C22664", "l": "Mouse Lutein Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "87.120474278337809", "identifiers": [{"i": "UMLS:C0333850", "l": "Hairy cell", "d": []}, {"i": "NCIT:C25288", "l": "Hairy Cell", "d": ["An abnormal large leukocyte found in the blood in hairy cell leukemia; it has numerous irregular cytoplasmic villi that give it a flagellated or hairy appearance."]}, {"i": "SNOMEDCT:112661003", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2331834", "l": "Brush cell of epithelium of lobular bronchiole", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5702551", "l": "Vitreous Seed", "d": []}, {"i": "NCIT:C189882", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002502", "l": "type M enteroendocrine cell", "d": ["An enteroendocrine cell of the small intestine that secretes motilin."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1182624", "l": "Basal cell of epidermis", "d": []}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "CL:0000626", "l": "olfactory granule cell", "d": ["A granule cell that has a soma located in an olfactory bulb granule cell layer. An olfactory granule cell is an interneuron that lacks an axon, makes reciprocal dendro-dendritic synapses with mitral cells and tufted cells and is involved in the fine spatio-temporal tuning of the responses of these principal olfactory bulb neurons to odors."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1518421", "l": "Nose - Nasal Cavity - Olfactory Cell (MMHCC)", "d": []}, {"i": "NCIT:C22726", "l": "Mouse Olfactory Cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5173060", "l": "Microcytes | Blood | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1182667", "l": "Endo-epithelial cell of tympanic part of viscerocranial mucosa", "d": []}]}
{"type": "biolink:Cell", "ic": "84.75972595860604", "identifiers": [{"i": "UMLS:C1514021", "l": "Neoplastic Megakaryoblast", "d": []}, {"i": "NCIT:C37068", "l": "Neoplastic Megakaryoblast", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5556332", "l": "Anti-Senl-h19 CAR T Cells", "d": []}, {"i": "NCIT:C180381", "l": "Anti-Senl-h19 CAR T Cells", "d": ["A preparation of T-lymphocytes that have been genetically modified to express a chimeric antigen receptor (CAR) targeting the human tumor-associated antigen (TAA) CD19, with potential immunostimulating and antineoplastic activities. Upon administration, anti-Senl-h19 CAR T cells target and bind to CD19-expressing tumor cells, thereby inducing selective toxicity in CD19-expressing tumor cells. CD19 antigen is a B-cell specific cell surface antigen expressed in all B-cell lineage malignancies."]}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "CL:4033025", "l": "perichondrial fibroblast", "d": ["A fibroblast that is part of the fibrous layer of the perichondrium. This cell is responsible for collagen fiber production."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1440050", "l": "Abnormal blood cells.CD14", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2340121", "l": "Fusiform cell of cerebral cortex", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5555016", "l": "Autologous Anti-PD-L1-armored Anti-CD22 CAR T Cells", "d": []}, {"i": "NCIT:C178409", "l": "Autologous Anti-PD-L1-armored Anti-CD22 CAR T Cells", "d": ["A preparation of autologous T-lymphocytes that have been genetically engineered to express a chimeric antigen receptor (CAR) specific for the human tumor-associated antigen (TAA) CD22 and carrying a single-chain variable fragment (scFv) of a monoclonal antibody targeting the immunosuppressive ligand programmed cell death-1 ligand 1 (PD-L1; cluster of differentiation 274; CD274), with potential immunomodulatory and antineoplastic activities. Upon infusion, the autologous anti-PD-L1-armored anti-CD22 CAR T cells target and bind to CD22-expressing tumor cells, thereby inducing selective toxicity in CD22-expressing tumor cells. The scFv moiety binds to PD-L1, blocking the binding of PD-L1 to its receptor programmed cell death 1 (PD-1; cluster of differentiation 279; CD279), thereby preventing PD-1 activation on T-lymphocytes. This reverses T-cell inactivation caused by PD-1/PD-L1 signaling and enhances the cytotoxic T-lymphocyte (CTL)-mediated anti-tumor immune response against PD-L1-expressing tumor cells. PD-L1 is overexpressed by many human cancer cell types and plays a key role in the downregulation of the immune system and tumor evasion from host immunity. PD-1, found on activated T-cells, negatively regulates T-cell activity; it plays a key role in immune evasion and prevents tumor cell lysis. CD22, a cell surface glycoprotein, is expressed on mature B-cells and on most malignant B-cells."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157379", "l": "CD20 cells | Blood | Cell markers", "d": []}]}
{"type": "biolink:Cell", "ic": "92.728541327098611", "identifiers": [{"i": "CL:1000548", "l": "kidney outer medulla collecting duct epithelial cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1648295", "l": "Cells.CD13+CD56+", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C4724902", "l": "Donor-derived Cytokine-induced Memory-like Natural Killer Cells", "d": []}, {"i": "NCIT:C148213", "l": "Donor-derived Cytokine-induced Memory-like Natural Killer Cells", "d": ["A population of donor-derived cytokine-induced, memory-like, cytotoxic natural killer (NK) cells (CIML NKs), with potential antitumor activity. Allogeneic NK cells are pre-activated ex vivo with various cytokines, which induces the differentiation of the NK cells into CIML NK cells. The pretreated NK cells exhibit enhanced activation and interferon-gamma (IFN-g) responses, and may exert enhanced cytotoxicity against tumor cells. Upon administration, the CIML NKs may induce an anti-tumor immune response and kill tumor cells."]}]}
{"type": "biolink:Cell", "ic": "36.512396635384071", "identifiers": [{"i": "UMLS:C0007634", "l": "Cells", "d": []}, {"i": "NCIT:C12508", "l": "Cell", "d": ["The smallest units of living structure capable of independent existence, composed of a membrane-enclosed mass of protoplasm and containing a nucleus or nucleoid."]}, {"i": "MESH:D002477", "l": "Cells", "d": []}, {"i": "SNOMEDCT:4421005", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5183792", "l": "Transitional cells | Urine | Urinalysis", "d": []}]}
{"type": "biolink:Cell", "ic": "84.75972595860604", "identifiers": [{"i": "CL:0000341", "l": "pigment cell (sensu Nematoda and Protostomia)", "d": []}]}
{"type": "biolink:Cell", "ic": "90.82444074280258", "identifiers": [{"i": "UMLS:C1517545", "l": "Giant Neoplastic Germ Cell", "d": []}, {"i": "NCIT:C37134", "l": "Giant Neoplastic Germ Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "46.676389026813908", "identifiers": [{"i": "CL:0000048", "l": "multi fate stem cell", "d": ["A stem cell that can give rise to multiple lineages of cells."]}]}
{"type": "biolink:Cell", "ic": "83.023198044254755", "identifiers": [{"i": "UMLS:C1514111", "l": "Neoplastic T-Lymphocyte with Clear Cytoplasm", "d": []}, {"i": "NCIT:C39657", "l": "Neoplastic T-Lymphocyte with Clear Cytoplasm", "d": []}]}
{"type": "biolink:Cell", "ic": "89.347505587204751", "identifiers": [{"i": "CL:0002013", "l": "GlyA-positive basophilic erythroblast", "d": ["A basophilic erythroblast that is GlyA-positive."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1182611", "l": "Conjunctival epithelial cell", "d": []}]}
{"type": "biolink:Cell", "ic": "92.728541327098611", "identifiers": [{"i": "CL:4023169", "l": "trigeminal neuron", "d": ["A neuron that is responsible for sensation in the face or motor functions such as biting and chewing. Trigeminal neurons extend a single axon shaft along the lateral white matter of the hindbrain and spinal cord. The highly branched axons innervate the integument of the head."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:4033018", "l": "lung megakaryocyte", "d": ["A megakaryocyte that is resident in the lung connective tissue."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0038027", "l": "Reproduction spores", "d": []}, {"i": "MESH:D013170", "l": "Spores", "d": []}]}
{"type": "biolink:Cell", "ic": "73.721563224321088", "identifiers": [{"i": "CL:0000113", "l": "mononuclear phagocyte", "d": ["A vertebrate phagocyte with a single nucleus."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5237351", "l": "Allogeneic CS1-specific Universal CAR-expressing T-lymphocytes UCARTCS1A", "d": []}, {"i": "NCIT:C165661", "l": "Allogeneic CS1-specific Universal CAR-expressing T-lymphocytes UCARTCS1A", "d": ["A preparation of allogeneic, off-the-shelf (OTS), universal transcription activator-like effector nuclease (TALEN)-engineered T-lymphocytes that have been genetically modified to express a chimeric antigen receptor (CAR) targeting the tumor-associated antigen (TAA) human CS1 (CD2 subset 1; SLAM family member 7; SLAMF7; CD319; CRACC), with potential immunomodulating and antineoplastic activities. Upon transfusion of allogeneic CS1-specific universal CAR-expressing T-lymphocytes UCARTCS1A, these cells target and bind to cancer cells expressing CS1. This induces selective toxicity in and causes lysis of CS1-expressing tumor cells. SLAMF7 is a member of the signaling lymphocytic activation molecule (SLAM) family of transmembrane receptors that modulate the function of immune cells through immunoreceptor tyrosine-based switch motifs (ITSMs) and intracellular adaptor proteins. SLAMF7 is highly expressed on certain malignant plasma cells and is minimally expressed on healthy immune cells."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1516727", "l": "Common Thymocyte", "d": []}, {"i": "NCIT:C32360", "l": "Common Thymocyte", "d": ["A lymphocyte found in the thymus. It is a precursor to a mature T-lymphocyte."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2340275", "l": "Microfold cell of epithelium proper of large intestine", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4695105", "l": "Kymriah (DLBCL)", "d": []}]}
{"type": "biolink:Cell", "ic": "92.728541327098611", "identifiers": [{"i": "CL:0001000", "l": "CD8_alpha-positive CD11b-negative dendritic cell", "d": ["CD8_alpha-positive CD11b-negative dendritic cell is a conventional dendritic cell that is CD11b-negative, CD4-negative and is CD205-positive and CD8_alpha-positive."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0682549", "l": "argentaffin cell (stain)", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4510906", "l": "Blast cell positive for CD15 antigen", "d": []}, {"i": "SNOMEDCT:724251005", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:1000301", "l": "fibroblast of subepithelial connective tissue of prostatic gland", "d": ["A fibroblast that is part of the subepithelial connective tissue of prostatic gland."]}]}
{"type": "biolink:Cell", "ic": "90.82444074280258", "identifiers": [{"i": "CL:0008012", "l": "quiescent skeletal muscle satellite cell", "d": ["A skeletal muscle satellite cell that is mitotically quiescent.  These cells are wedge shaped and have a large nuclear to cytoplasmic ratio with few organelles, a small nucleus and condensed interphase chromatin. Satellite cells typically remain in this state until activated following muscle damage."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2324444", "l": "Set of adrenergic cells in anterior reticular nucleus [C2]", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C3831169", "l": "CD19CAR-CD28zeta-4-1BB-expressing Allogeneic T Lymphocytes", "d": []}, {"i": "NCIT:C107242", "l": "CD19CAR-CD28zeta-4-1BB-expressing Allogeneic T Lymphocytes", "d": ["Allogeneic T-lymphocytes transduced with a retroviral vector expressing a chimeric antigen receptor (CAR) consisting of an anti-CD19 scFv (single chain variable fragment) coupled to the costimulatory signaling domain CD28, the signaling domain of 4-1BB (CD137), and the zeta chain of the T-cell receptor (TCR), with potential immunomodulating and antineoplastic activities. Upon transfusion, CD19CAR-CD28 zeta-4-1BB-expressing allogeneic T lymphocytes directs the T-lymphocytes to and induces selective toxicity in CD19-expressing tumor cells. CD28, a T-cell surface-associated co-stimulatory molecule, is required for T-cell activation, proliferation, and survival. The 4-1BB co-stimulatory molecule signaling domain enhances activation and signaling after recognition of CD19. Furthermore, inclusion of the 4-1BB signaling domain may increase the antitumor activity compared to the inclusion of the CD28 costimulatory domain and TCR zeta chain alone. CD19 antigen is a B-cell specific cell surface antigen, which is expressed in all B-cell lineage malignancies."]}]}
{"type": "biolink:Cell", "ic": "69.653168928076894", "identifiers": [{"i": "UMLS:C1514076", "l": "Neoplastic Round Cell", "d": []}, {"i": "NCIT:C37099", "l": "Neoplastic Round Cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157595", "l": "CD5 cells | Blood | Cell markers", "d": []}]}
{"type": "biolink:Cell", "ic": "44.057379842415024", "identifiers": [{"i": "UMLS:C1518246", "l": "Malignant Stromal Cell", "d": []}, {"i": "NCIT:C37153", "l": "Malignant Stromal Cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4697025", "l": "Cells.CD27+IgD-IgM-", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1135919", "l": "Myoblasts, Smooth Muscle", "d": []}, {"i": "MESH:D032390", "l": "Myoblasts, Smooth Muscle", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C3830334", "l": "EFS-ADA Lentiviral Vector-transduced CD34-positive Autologous Lymphocytes", "d": []}, {"i": "NCIT:C113438", "l": "EFS-ADA Lentiviral Vector-transduced CD34-positive Autologous Lymphocytes", "d": ["A preparation of autologous, CD34-positive stem/progenitor cells transduced with a lentrivral vector encoding the human adenosine deaminase (ADA) gene under the control of the human elongation factor alpha short promoter (EFS), with potential to restore ADA expression and function. Autologous hematopoietic CD34+ cells are isolated from the patient's own bone marrow, peripheral blood or cord blood, and transduced with the EFS-ADA lentiviral vector ex vivo. Upon re-infusion of the EFS-ADA vector-transduced lymphocytes back into the patient, these cells may both restore ADA activity and prevent severe combined immunodeficiency (SCID) due to ADA deficiency. ADA, an enzyme that catalyzes the deamination of adenosine to inosine, plays a key role in the development and functioning of the immune system."]}]}
{"type": "biolink:Cell", "ic": "78.185623981295834", "identifiers": [{"i": "UMLS:C1519550", "l": "Dental pulp cell", "d": []}, {"i": "NCIT:C33793", "l": "Tooth Cell", "d": ["The cell of the tooth. It includes the odontoblast, cementoblast, cementocyte, and ameloblast."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5419241", "l": "Rexlemestrocel-L", "d": []}, {"i": "NCIT:C171655", "l": "Rexlemestrocel-L", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4484158", "l": "Cells.chromosome 3 monosomy", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157445", "l": "CD3+CD45+ cells | Blood | Cell markers", "d": []}]}
{"type": "biolink:Cell", "ic": "69.133783595722377", "identifiers": [{"i": "CL:0000623", "l": "natural killer cell", "d": ["A lymphocyte that can spontaneously kill a variety of target cells without prior antigenic activation via germline encoded activation receptors and also regulate immune responses via cytokine release and direct contact with other cells."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002680", "l": "PP cell of intestine", "d": ["A PP cell found in intestine."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1978098", "l": "Prekeratocytes", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4322738", "l": "CD57+ T lymphocyte", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0487770", "l": "CD16+CD57- lymphocyte", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157520", "l": "CD3-CD16+CD56+ (Natural killer) cells | Bone marrow | Cell markers", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002564", "l": "nucleus pulposus cell of intervertebral disc", "d": ["A connective tissue cell of the nucleus pulposus cell of intervertebral disc."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0882791", "l": "Cell positive for CD13 antigen", "d": []}, {"i": "SNOMEDCT:116751002", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5163725", "l": "Erythrocytes | Seminal plasma | Fertility testing", "d": []}]}
{"type": "biolink:Cell", "ic": "83.023198044254755", "identifiers": [{"i": "CL:1001434", "l": "olfactory bulb interneuron", "d": ["A neuron residing in the olfactory bulb that serve to process and refine signals arising from olfactory sensory neurons"]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5173469", "l": "Monocytes+Macrophages | Pericardial fluid | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "ic": "87.120474278337809", "identifiers": [{"i": "CL:0002454", "l": "Cd4-negative, CD8_alpha-negative, CD11b-positive dendritic cell", "d": ["Cd4-negative, CD8_alpha-negative, CD11b-positive dendritic cell is a conventional dendritic cell that is CD11b-positive, CD4-negative, CD8_alpha-negative and is CD205-positive."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5426634", "l": "Cells.CD3-CD14-CD19+CD45+DOCK8+", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5216292", "l": "Neutrophils|NCnc|Pt|CSF", "d": []}]}
{"type": "biolink:Cell", "ic": "60.665996090425516", "identifiers": [{"i": "UMLS:C3899265", "l": "Endocrine Cell of the Digestive System", "d": []}, {"i": "NCIT:C12573", "l": "Endocrine Cell of the Digestive System", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5175158", "l": "Nucleated erythrocytes | Body fluid | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1956386", "l": "Interstitial Dendritic Cells", "d": []}]}
{"type": "biolink:Cell", "ic": "83.552982069901191", "identifiers": [{"i": "CL:0002620", "l": "skin fibroblast", "d": ["A fibroblast of skin."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5426719", "l": "Viable CD3 cells", "d": []}]}
{"type": "biolink:Cell", "ic": "90.82444074280258", "identifiers": [{"i": "CL:1001585", "l": "appendix glandular cell", "d": ["Glandular cell of appendix epithelium. Example: Goblet cells; enterocytes or absorptive cells; enteroendocrine and M cells."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1267852", "l": "Lymphocyte positive for CD7 antigen", "d": []}, {"i": "SNOMEDCT:117538001", "d": []}]}
{"type": "biolink:Cell", "ic": "84.75972595860604", "identifiers": [{"i": "CL:0000907", "l": "central memory CD8-positive, alpha-beta T cell", "d": ["CD8-positive, alpha-beta memory T cell with the phenotype CCR7-positive, CD127-positive, CD45RA-negative, CD45RO-positive, and CD25-negative."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0178708", "l": "immortalized cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5174615", "l": "Neutrophils | Cerebral spinal fluid | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:2000072", "l": "adipose microvascular endothelial cell", "d": ["Any microvascular endothelial cell that is part of a adipose tissue."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0884134", "l": "Cells.CD24", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5216320", "l": "Smudge cells|NCnc|Pt|Bld", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1440345", "l": "Cells.CD66c", "d": []}]}
{"type": "biolink:Cell", "ic": "92.728541327098611", "identifiers": [{"i": "CL:0007000", "l": "preameloblast", "d": ["Skeletogenic cell that has the potential to develop into an ameloblast. Located in the inner enamel epithelium, these cells elongate, their nuclei shift distally (away from the dental papilla), and their cytoplasm becomes filled with organelles needed for synthesis and secretion of enamel proteins."]}]}
{"type": "biolink:Cell", "ic": "54.000520004740416", "identifiers": [{"i": "UMLS:C1519006", "l": "Peripheral (Post-Thymic) T-Lymphocyte and Natural Killer Cell", "d": []}, {"i": "NCIT:C39568", "l": "Peripheral (Post-Thymic) T-Lymphocyte and Natural Killer Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C4683836", "l": "IL13Ralpha2-specific Hinge-optimized 4-1BB-co-stimulatory CAR/Truncated CD19-expressing Autologous TN/MEM Cells", "d": []}, {"i": "NCIT:C141460", "l": "IL13Ralpha2-specific Hinge-optimized 4-1BB-co-stimulatory CAR/Truncated CD19-expressing Autologous TN/MEM Cells", "d": ["A preparation of ex vivo expanded, genetically modified autologous naïve and memory T-cells (TN/MEM) transduced with a replication incompetent, self-inactivating (SIN) lentiviral vector expressing a hinge-optimized, chimeric antigen receptor (CAR) specific for interleukin-13 receptor alpha 2 (IL13Ra2), and containing the cluster of differentiation 137 (CD137; 4-1BB) co-stimulatory signaling domain fused to the signaling domain of the T-cell antigen receptor complex zeta chain (CD3-zeta), and a truncated form of human cluster of differentiation 19 (CD19t), with potential immunostimulating and antineoplastic activities. Upon intratumoral or intracavitary administration, IL13Ra2-specific hinge-optimized 4-1BB-co-stimulatory CAR/truncated CD19-expressing autologous TN/MEM cells are directed to, and induce selective toxicity and cytolysis in, IL13Ra2-expressing tumor cells. IL13Ra2, overexpressed by a variety of tumor cell types, is associated with increased proliferation, migration and invasiveness of tumor cells. The co-stimulatory signaling domain enhances both proliferation of T-cells and antitumor activity. Hinge optimization prevents the recognition and clearance of the CAR by endogenous Fc receptors (FcRs). CD19t is used as a surface marker to both track and quantify the modified T-cells in vivo."]}]}
{"type": "biolink:Cell", "ic": "59.390126070323255", "identifiers": [{"i": "CL:0000058", "l": "chondroblast", "d": ["Skeletogenic cell that is typically non-terminally differentiated, secretes an avascular, GAG rich matrix; is not buried in cartilage tissue matrix, retains the ability to divide, located adjacent to cartilage tissue (including within the perichondrium), and develops from prechondroblast (and thus prechondrogenic) cell."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1267996", "l": "Lymphocyte positive for CD117 antigen", "d": []}, {"i": "SNOMEDCT:117436000", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4512367", "l": "Entire glia", "d": []}, {"i": "SNOMEDCT:727123002", "d": []}]}
{"type": "biolink:Cell", "ic": "90.82444074280258", "identifiers": [{"i": "UMLS:C0333741", "l": "Touton giant cell", "d": []}, {"i": "NCIT:C36732", "l": "Touton Giant Cell", "d": []}, {"i": "SNOMEDCT:71203006", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C0369668", "l": "Microcytic erythrocyte (cell)", "d": []}, {"i": "NCIT:C37034", "l": "Microcytic Red Blood Cell", "d": []}, {"i": "SNOMEDCT:397022008", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157600", "l": "CD5+CD23+ cells | Blood | Cell markers", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1267795", "l": "Mononuclear cell (histiocyte, lymphocyte, plasma cell)", "d": []}, {"i": "SNOMEDCT:116711000", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2709162", "l": "Mycobacterium tuberculosis A60", "d": []}]}
{"type": "biolink:Cell", "ic": "34.994020854650032", "identifiers": [{"i": "CL:0002319", "l": "neural cell", "d": ["A cell that is part of the nervous system."]}]}
{"type": "biolink:Cell", "ic": "65.665902432881424", "identifiers": [{"i": "UMLS:C1135918", "l": "Myocytes, Smooth Muscle", "d": []}, {"i": "NCIT:C13001", "l": "Smooth Muscle Cell", "d": ["An elongated spindle-shaped contractile cell, peculiar to an involuntary muscle, containing a single nucleus and longitudinally arranged myofibrils."]}, {"i": "MESH:D032389", "l": "Myocytes, Smooth Muscle", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0009034", "l": "dendritic cell of appendix", "d": ["A dendritic cell that is located in a vermiform appendix."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157230", "l": "CD1 blasts | XXX | Cell markers", "d": []}]}
{"type": "biolink:Cell", "ic": "90.82444074280258", "identifiers": [{"i": "CL:4023123", "l": "hypothalamus kisspeptin neuron", "d": ["A kisspeptin neuron that is located in the hypothalamus. These neurons project to and activate gonadotrophin-releasing hormone neurons (acting via the kisspeptin receptor) in the hypothalamus and stimulate the secretion of gonadotrophin-releasing hormone."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002641", "l": "epithelial cell of esophageal gland proper", "d": ["An epithelial cell of the esophageal gland proper."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4518145", "l": "Population of all spermatozoa with duplicate tail in portion of fluid", "d": []}, {"i": "SNOMEDCT:725244008", "d": []}]}
{"type": "biolink:Cell", "ic": "70.517713470395833", "identifiers": [{"i": "UMLS:C0222677", "l": "Cell of bone", "d": []}, {"i": "NCIT:C48762", "l": "Bone Cell", "d": []}, {"i": "SNOMEDCT:3400000", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5556435", "l": "Autologous Anti-gp100:154-162 TCR Tumor Infiltrating Lymphocytes", "d": []}, {"i": "NCIT:C180517", "l": "Autologous Anti-gp100:154-162 TCR Tumor Infiltrating Lymphocytes", "d": ["A preparation of human tumor infiltrating lymphocytes (TILs) isolated from a melanoma patient and engineered to encode a T-cell receptor (TCR) specific for the amino acid 154 through 162 of the melanoma antigen glycoprotein 100 (gp100), with potential immunomodulating and antineoplastic activities. Upon intravenous administration, the autologous anti-gp100:154-162 TCR TILs may recognize and halt the growth of gp100-expressing melanoma cells."]}]}
{"type": "biolink:Cell", "ic": "43.272309606068639", "identifiers": [{"i": "UMLS:C1518174", "l": "Malignant Epithelial Cell", "d": []}, {"i": "NCIT:C36779", "l": "Malignant Epithelial Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "84.128890093485552", "identifiers": [{"i": "CL:0002062", "l": "type I pneumocyte", "d": ["A type I pneumocyte is a flattened, branched pneumocyte that covers more than 98% of the alveolar surface. This large cell has thin (50-100 nm) cytoplasmic extensions to form the air-blood barrier essential for normal gas exchange."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0000629", "l": "storage cell", "d": ["A cell that is specialized to store a particular substance(s), which is(are) later released from the store for a particular purpose."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5556478", "l": "Dual-target CAR T Cells C-4-29", "d": []}, {"i": "NCIT:C180586", "l": "Dual-target CAR T Cells C-4-29", "d": ["A preparation of human T-lymphocytes that have been genetically modified to express a dual-target CAR, with potential immunostimulating and antineoplastic activities. Upon administration, the dual-target CAR T cells C-4-29 recognize and kill tumor cells expressing the two as of yet undisclosed targets. This results in a cytotoxic T-lymphocyte (CTL) response against these tumor cells, thereby causing tumor cell lysis."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C0000886", "l": "Acanthocytes", "d": []}, {"i": "NCIT:C12523", "l": "Acanthocyte", "d": ["An abnormal red blood cell, characterized by an irregularly spiculated cell membrane, that is typically associated with abetalipoproteinemia or liver disease."]}, {"i": "MESH:D000050", "l": "Acanthocytes", "d": []}, {"i": "SNOMEDCT:63599005", "d": []}]}
{"type": "biolink:Cell", "ic": "85.457082654197222", "identifiers": [{"i": "CL:4023010", "l": "alpha7 GABAergic cortical interneuron (Mmus)", "d": ["A GABAergic cortical interneuron that is strongly labelled for α7 nAChRs. These cells have soma found in L1 and have multipolar dendrites with vertically descending axonal collaterals that project deep into the column, usually branching and terminating in L5A."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1518752", "l": "Mouse Ovarian Interstitial Cell", "d": []}, {"i": "NCIT:C22663", "l": "Mouse Ovarian Interstitial Cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1545578", "l": "Neutrophils.hypogranulated", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C4744691", "l": "Partially HLA-matched AdV/CMV/EBV-specific Allogeneic T-Lymphocytes", "d": []}, {"i": "NCIT:C156256", "l": "Partially HLA-matched AdV/CMV/EBV-specific Allogeneic T-Lymphocytes", "d": ["Partially or closely human leukocyte antigen (HLA)-matched allogeneic cytotoxic T-lymphocytes (CTLs), derived from cell lines, specifically reactive to the three human viruses adenovirus (AdV), cytomegalovirus (CMV) and Epstein-Barr virus (EBV), with potential antiviral activity. Upon infusion of the partially HLA-matched AdV/CMV/EBV-specific allogeneic T-lymphocytes in immunocompromised patients or upon allogeneic hematopoietic stem cell transplantation (HSCT) in an immunodeficient recipient, these CTLs may kill AdV, CMV, and/or EBV-infected cells, and may prevent or reduce the severity of viral infections by these pathogens."]}]}
{"type": "biolink:Cell", "ic": "56.989385079556939", "identifiers": [{"i": "UMLS:C4329351", "l": "Antineoplastic Immune Cell", "d": []}, {"i": "NCIT:C129826", "l": "Antineoplastic Immune Cell", "d": ["Any immune cell-based preparation that can be used or may potentially be used for its cytotoxic activity against cancer cells."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5447497", "l": "Allogeneic shRNA-based Anti-BCMA CAR T-cells CYAD-211", "d": []}, {"i": "NCIT:C176885", "l": "Allogeneic shRNA-based Anti-BCMA CAR T-cells CYAD-211", "d": ["A preparation of human allogeneic, 'off-the-shelf' (OTS), non-gene edited T-lymphocytes that are engineered to co-express a chimeric antigen receptor (CAR) specific for the tumor-associated antigen (TAA) human B-cell maturation antigen (BCMA; tumor necrosis factor receptor superfamily member 17; TNFRSF17) and a single short hairpin RNA (shRNA) that disrupts the expression of the CD3zeta component of the T-cell receptor (TCR), with potential immunostimulating and antineoplastic activities. Upon administration, the allogeneic shRNA-based anti-BCMA CAR T-cells CYAD-211 recognize and bind to BCMA-overexpressing tumor cells. This may result in a specific cytotoxic T-lymphocyte (CTL)-mediated killing of BCMA-expressing tumor cells. BCMA, a receptor for both a proliferation-inducing ligand (APRIL) and B-cell activating factor (BAFF), is a member of the tumor necrosis factor receptor superfamily (TNFRSF) and plays a key role in plasma cell survival. BCMA is found on the surfaces of plasma cells and overexpressed on malignant plasma cells. The downregulation of the expression of the TCR CD3zeta subunit by shRNA prevents the potential induction of graft-versus-host disease (GvHD) by the donor T-cells."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0229572", "l": "Supporting cell of carotid body", "d": []}, {"i": "SNOMEDCT:37269007", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0000603", "l": "dikaryon", "d": ["A fungal cell with two genetically distinct haploid nuclei."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157431", "l": "CD3+CD25+ cells | Bone marrow | Cell markers", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002298", "l": "type-5 epithelial cell of thymus", "d": ["A thymic epithelial cell type with low nuclear and cytoplasmic electrondensity; has a round, euchromatic nucleus and occurs in small groups at the corticomedullary junction or scattered singly in the medulla."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2953492", "l": "Set of neural cells", "d": []}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "CL:0002673", "l": "tongue muscle cell", "d": ["A skeletal muscle cell that is part of the tongue."]}]}
{"type": "biolink:Cell", "ic": "75.751739371353352", "identifiers": [{"i": "UMLS:C1514034", "l": "Neoplastic Myeloblast", "d": []}, {"i": "NCIT:C37065", "l": "Neoplastic Myeloblast", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5171656", "l": "Lymphocytes | Blood | Cell markers", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002232", "l": "epithelial cell of prostatic duct", "d": ["An epithelial cell of prostatic duct."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2323958", "l": "Double bouquet cell of cerebral cortex", "d": []}]}
{"type": "biolink:Cell", "ic": "81.247621244257502", "identifiers": [{"i": "CL:0002435", "l": "CD69-positive, CD8-positive single-positive thymocyte", "d": ["A CD8-positive, CD4-negative thymocyte that expresses high levels of the alpha-beta T cell receptor and is CD69-positive."]}]}
{"type": "biolink:Cell", "ic": "92.728541327098611", "identifiers": [{"i": "CL:0001021", "l": "CD34-positive, CD38-positive common lymphoid progenitor", "d": ["A common lymphoid progenitor that is CD10-positive, CD45RA-positive, CD34-positive and CD38-positive."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5706419", "l": "Allogeneic Gamma-delta T-lymphocytes TCB-008", "d": []}, {"i": "NCIT:C187650", "l": "Allogeneic Gamma-delta T-lymphocytes TCB-008", "d": ["A preparation of ex vivo-expanded, allogeneic T-lymphocytes that express only gamma chain and delta chain T-cell receptors (TCRs), with potential immunomodulating and antineoplastic activities. Upon administration of the allogeneic gamma-delta T-lymphocytes TCB-008, these cells secrete interferon-gamma (IFN-g) and exert direct killing of tumor cells. In addition, these cells activate the immune system to exert a cytotoxic T-lymphocyte (CTL) response against tumor cells. Gamma-delta T-lymphocytes play a key role in the activation of the immune system and do not require major histocompatibility complex (MHC)-mediated antigen presentation to exert their cytotoxic effect."]}]}
{"type": "biolink:Cell", "ic": "86.236661114203869", "identifiers": [{"i": "CL:0000861", "l": "elicited macrophage", "d": ["A macrophage which develops from an inflammatory monocyte and is recruited into the tissues in response to injury and infection as part of an inflammatory response. Markers include CD11b-positive, CD68-positive, and F4/80-positive."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1513018", "l": "Neoplastic Mature-Appearing Adipocyte", "d": []}, {"i": "NCIT:C36976", "l": "Neoplastic Mature-Appearing Adipocyte", "d": []}]}
{"type": "biolink:Cell", "ic": "48.166978709185059", "identifiers": [{"i": "UMLS:C0024264", "l": "Lymphocyte", "d": []}, {"i": "NCIT:C12535", "l": "Lymphocyte", "d": ["White blood cells formed in the body's lymphoid tissue. The nucleus is round or ovoid with coarse, irregularly clumped chromatin while the cytoplasm is typically pale blue with azurophilic (if any) granules. Most lymphocytes can be classified as either T or B (with subpopulations of each); those with characteristics of neither major class are called null cells."]}, {"i": "MESH:D008214", "l": "Lymphocytes", "d": []}, {"i": "SNOMEDCT:56972008", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1440149", "l": "Blasts.CD7", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0019029", "l": "centrilobular region hepatocyte", "d": ["Any hepatocyte that is part of the liver lobule centrilobular region. These cells are the primary location for the biotransformation of drugs."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002163", "l": "internal pillar cell of cochlea", "d": ["A rod-shpaed cell that forms a single row adjacent to and supporting the inner hair cells."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2350826", "l": "Rhabdomeric Photoreceptor Cells", "d": []}]}
{"type": "biolink:Cell", "ic": "49.200422100521919", "identifiers": [{"i": "CL:0007001", "l": "skeletogenic cell", "d": ["Cell that has the potential to form a skeletal cell type (e.g. cells in periosteum, cells in marrow) and produce extracellular matrix (often mineralized) and skeletal tissue (often mineralized)."]}]}
{"type": "biolink:Cell", "ic": "89.347505587204751", "identifiers": [{"i": "UMLS:C1513957", "l": "Neoplastic Eosinophilic Cell Oncocyte", "d": []}, {"i": "NCIT:C37166", "l": "Neoplastic Eosinophilic Cell Oncocyte", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1522117", "l": "Leukocyte - Lymphocyte - B-Lymphocyte - Plasma Cell (MMHCC)", "d": []}, {"i": "NCIT:C22577", "l": "Mouse Plasma Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0009083", "l": "rearranging double negative thymocyte (Homo sapiens)", "d": ["The human equivalent of a DN4 thymocyte."]}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "UMLS:C0030559", "l": "Parietal Cells, Gastric", "d": []}, {"i": "NCIT:C12594", "l": "Parietal Cell", "d": ["A large epithelial cell located in the mucous membrane of the stomach that secretes gastric intrinsic factor and hydrochloric acid."]}, {"i": "MESH:D010295", "l": "Parietal Cells, Gastric", "d": []}, {"i": "SNOMEDCT:57041003", "d": []}]}
{"type": "biolink:Cell", "ic": "92.728541327098611", "identifiers": [{"i": "UMLS:C1514979", "l": "Strap-Like Skeletal Muscle Cell", "d": []}, {"i": "NCIT:C36948", "l": "Strap-Like Skeletal Muscle Cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1267909", "l": "Lymphoblast positive for CD34 antigen", "d": []}, {"i": "SNOMEDCT:117580002", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0019000", "l": "Hemocytes (cell)", "d": []}, {"i": "MESH:D006434", "l": "Hemocytes", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4300402", "l": "Cells.chromosome region 5q31 deletion", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5206589", "l": "Autologous CD138-specific CAR T-cells", "d": []}, {"i": "NCIT:C162482", "l": "Autologous CD138-specific CAR T-cells", "d": ["A preparation of autologous T-lymphocytes that have been engineered to express a chimeric antigen receptor (CAR) specific for syndecan-1 (CD138), with potential immunomodulating and antineoplastic activities. Upon administration, the autologous CD138 CAR-expressing T-cells target and induce selective toxicity in syndecan-1-expressing tumor cells. Syndecan-1, a type 1 transmembrane proteoglycan and tumor-associated antigen (TAA), is overexpressed in a variety of cancer cells and plays a key role in the regulation of cell growth, differentiation, and adhesion."]}]}
{"type": "biolink:Cell", "ic": "84.75972595860604", "identifiers": [{"i": "UMLS:C1518244", "l": "Malignant Spindle Squamous Cell", "d": []}, {"i": "NCIT:C36775", "l": "Malignant Spindle Squamous Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "UMLS:C1513955", "l": "Neoplastic Endocrine Null Cell", "d": []}, {"i": "NCIT:C36923", "l": "Neoplastic Endocrine Null Cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1181301", "l": "Inactive chief cell of parathyroid gland", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1440422", "l": "Cells.TCR gamma delta", "d": []}]}
{"type": "biolink:Cell", "ic": "89.347505587204751", "identifiers": [{"i": "CL:0000326", "l": "glycogen accumulating cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1267703", "l": "Inner mesothelial cell of arachnoid", "d": []}, {"i": "SNOMEDCT:110662000", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1265905", "l": "Oat cell", "d": []}, {"i": "NCIT:C36762", "l": "Oat Cell", "d": []}, {"i": "SNOMEDCT:125409002", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:4033034", "l": "invaginating midget bipolar cell", "d": ["An ON bipolar cell with a small dendritic tree that forms most of the central (invaginating) elements opposite the synaptic ribbon at the cone triad."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0003027", "l": "retinal ganglion cell D2", "d": ["A bistratified retinal ganglion cell D cell that has medium dendritic arbor and a large dendritic field that terminates in S2 and S4."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4530304", "l": "Yescarta", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C3827138", "l": "Autologous CT7/MAGE-A3/WT1 mRNA-Electroporated Langerhans-Type Dendritic Cells", "d": []}, {"i": "NCIT:C113174", "l": "Autologous CT7/MAGE-A3/WT1 mRNA-Electroporated Langerhans-Type Dendritic Cells", "d": ["An autologous tumor cell vaccine containing CD34+ hematopoietic progenitor cell (HPC)-derived Langerhans-type dendritic cells (LCs) electroporated with mRNA encoding the full-length cancer-testis antigens, CT7 and melanoma-associated antigen 3 (MAGE-A3), and the self-differentiation tumor antigen, Wilms tumor 1 (WT1) with potential immunomodulating and antineoplastic activity. The autologous CT7/MAGE-A3/WT1 mRNA-electroporated Langerhans-type dendritic cells are prepared by drawing a blood sample containing the CD34+ HPCs from a cancer patient. The CD34+ HPCs are treated with a combination of cytokines which specifically support LC development, and the LC population is enriched and expanded ex vivo. The cultured LCs are allowed to mature for one day and then electroporated separately with CT7, MAGE-A3 or WT1 mRNA before final maturation. Upon intradermal administration into the patient, the mature LCs may activate cell-mediated immunity and induce both cytotoxic CD8+ T cells and CD4+ helper T cells against cancer cells expressing CT7, MAGE-A3 and WT1 tumor antigens. This may result in the immune-mediated inhibition of tumor cell proliferation, leading to tumor cell death. CT7 and MAGE-A3 are tumor-specific proteins overexpressed in a number of cancers but not in healthy tissues other than testis and placenta. WT1 is a transcription factor important in development and cancer pathogenesis, which is overexpressed in a variety of cancers, including multiple myeloma, leukemia, ovarian cancer, malignant mesothelioma, neural tumors and renal carcinoma."]}]}
{"type": "biolink:Cell", "ic": "82.532694649739099", "identifiers": [{"i": "CL:0011001", "l": "spinal cord motor neuron", "d": ["A motor neuron that passes from the spinal cord toward or to a muscle and conducts an impulse that causes movement."]}]}
{"type": "biolink:Cell", "ic": "92.728541327098611", "identifiers": [{"i": "UMLS:C1321301", "l": "Peripheral blood mononuclear cell (cell)", "d": []}, {"i": "NCIT:C12954", "l": "Peripheral Blood Mononuclear Cell", "d": ["A peripheral blood cell with a single nucleus. This category includes lymphocytes and monocytes."]}, {"i": "SNOMEDCT:404798000", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4684961", "l": "Tabelecleucel", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002134", "l": "stromal cell of ovarian medulla", "d": ["A stromal cell of the ovarian medulla."]}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "UMLS:C1516094", "l": "Atypical Epithelioid Cell", "d": []}, {"i": "NCIT:C37118", "l": "Atypical Epithelioid Cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5216226", "l": "Leukocytes other|NCnc|Pt|Pericard fld", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4253034", "l": "Epithelial cell of prostatic urethra", "d": []}]}
{"type": "biolink:Cell", "ic": "70.216808612803263", "identifiers": [{"i": "CL:0000946", "l": "antibody secreting cell", "d": ["A lymphocyte of B lineage that is devoted to secreting large amounts of immunoglobulin."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5171871", "l": "Macrophages | Urine sediment | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1440348", "l": "Cells.CD68", "d": []}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "UMLS:C0333862", "l": "Giant megakaryocyte", "d": []}, {"i": "NCIT:C37045", "l": "Giant Megakaryocyte", "d": []}, {"i": "SNOMEDCT:60191001", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:1001109", "l": "kidney loop of Henle cortical thick ascending limb epithelial cell", "d": ["An epithelial cell that is part of some loop of Henle thick ascending limb segment located in the renal cortex."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0369738", "l": "Neutrophils.band form", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1440318", "l": "Cells.CD46", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157601", "l": "CD5+CD25+ cells | Blood | Cell markers", "d": []}]}
{"type": "biolink:Cell", "ic": "92.728541327098611", "identifiers": [{"i": "CL:0002184", "l": "basal proper cell of olfactory epithelium", "d": ["A flat or angular epithelial cell with condensed nuclei and darkly staining cytoplasm containing numerous intermediate filaments inserted into desmosomes contacting surrounding supporting cells; lie in contact with the basal lamina of olfactory epithelium."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0009005", "l": "salivary gland cell", "d": ["Any cell in a salivary gland."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5177778", "l": "Polymorphonuclear cells | Body fluid | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "CL:2000078", "l": "placental pericyte", "d": ["Any pericyte cell that is part of a placenta."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1182797", "l": "Epithelial cell of intermediate tubule", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4518165", "l": "Population of all spermatozoa with abnormal head shape in portion of fluid", "d": []}, {"i": "SNOMEDCT:725223008", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1267994", "l": "Lymphocyte positive for CD107B antigen", "d": []}, {"i": "SNOMEDCT:117434002", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0427527", "l": "Cleft lymphocyte", "d": []}, {"i": "SNOMEDCT:134202006", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C4733630", "l": "Autologous Ovarian Cancer-specific Cytotoxic T-Lymphocytes", "d": []}, {"i": "NCIT:C155664", "l": "Autologous Ovarian Cancer-specific Cytotoxic T-Lymphocytes", "d": ["A preparation of autologous cytotoxic T-lymphocytes (CTLs) genetically modified to target a not yet disclosed ovarian cancer-specific tumor-associated antigen (TAA), with potential immunomodulating and antineoplastic activities. After isolation, transduction, expansion in culture, and reintroduction into the patient, the autologous ovarian cancer-specific cytotoxic T-lymphocytes (OC-CTLs) bind to and induce selective toxicity in tumor cells expressing the TAA."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1440234", "l": "Cell positive for CD102 protein", "d": []}, {"i": "SNOMEDCT:725326002", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1440245", "l": "Cells.CD11a", "d": []}]}
{"type": "biolink:Cell", "ic": "74.659114980698789", "identifiers": [{"i": "CL:0002293", "l": "epithelial cell of thymus", "d": ["An epithelial cell of the thymus. Epithelial reticular cells are pleomorphic, stellate, non-phagocytic cells which seem to be supportive in function and are held together by desmosomes. They replace the fibroblastoid reticular cells found in other lymphoid organs. Other epithelial cells in the medulla have the ultrastructure of secretory cells. Although different epithelial cells throughout the thymus appear alike by light microscopy their ultrastructure and function varies."]}]}
{"type": "biolink:Cell", "ic": "65.16748027341059", "identifiers": [{"i": "CL:0001012", "l": "CD7-negative lymphoid progenitor OR granulocyte monocyte progenitor", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "MESH:D053058", "l": "Trophozoites", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1522099", "l": "Leukocyte - Lymphoblast (MMHCC)", "d": []}, {"i": "NCIT:C22571", "l": "Mouse Lymphoblast", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5166080", "l": "Granulocytes | Body fluid | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0004125", "l": "retinal ganglion cell C2 inner", "d": ["A retinal ganglion cell C inner that has dense dendritic diversity."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C2984034", "l": "Allogeneic Cytomegalovirus-Specific Cytotoxic T lymphocytes", "d": []}, {"i": "NCIT:C91095", "l": "Allogeneic Cytomegalovirus-Specific Cytotoxic T lymphocytes", "d": ["A population of allogeneic cytotoxic T lymphocytes (CTLs) specifically reactive to the herpes virus cytomegalovirus (CMV) with potential immunomodulating and antiviral activities. Upon immunoprophylactic adoptive cell therapy infusion with allogeneic cytomegalovirus-specific cytotoxic T lymphocytes, these CTLs may help reconstitute CMV-specific CTL responses in CMV-infected immunocompromised hosts after allogeneic hematopoietic stem cell transplant, thereby potentially preventing the occurrence of CMV viral disease or reducing the amount of antiviral drug therapy."]}]}
{"type": "biolink:Cell", "ic": "92.728541327098611", "identifiers": [{"i": "CL:0000654", "l": "primary oocyte", "d": ["A primary oocyte is an oocyte that has not completed female meosis I."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0000996", "l": "mature CD11c-negative plasmacytoid dendritic cell", "d": ["Mature CD11c-negative plasmacytoid dendritic cell is a CD11c-negative plasmacytoid dendritic cell is CD80-high, CD86-high, MHCII-high and is CD83-positive."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1182623", "l": "Unipotent stem cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5427574", "l": "Ganglion cells.left", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0205867", "l": "Interfascicular Oligodendroglia", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2930257", "l": "Autologous cultured chondrocyte", "d": []}, {"i": "SNOMEDCT:840610002", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4517379", "l": "Population of all large unstained cells in portion of fluid", "d": []}, {"i": "SNOMEDCT:732290004", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:1000394", "l": "myoepithelial cell of intralobular lactiferous duct", "d": ["A myoepithelial cell that is part of the intralobular part of terminal lactiferous duct."]}]}
{"type": "biolink:Cell", "ic": "86.236661114203869", "identifiers": [{"i": "CL:0000803", "l": "CD4-negative CD8-negative gamma-delta intraepithelial T cell", "d": ["A gamma-delta intraepithelial T cell that has the phenotype CD4-negative and CD8-negative."]}]}
{"type": "biolink:Cell", "ic": "75.105493098994543", "identifiers": [{"i": "UMLS:C0036387", "l": "Schwann Cells", "d": []}, {"i": "NCIT:C12620", "l": "Schwann Cell", "d": ["A supporting cell of the peripheral nervous system that aids the growth, development, function, maintenance and repair of peripheral nerves. Myelinating Schwann cells form the myelin sheath around large diameter axons while non-myelinating Schwann cells bundle together portions of several unmyelinated smaller diameter axons and may also play a role in the formation and maintenance of synaptic connections in the neuromuscular junction."]}, {"i": "MESH:D012583", "l": "Schwann Cells", "d": []}, {"i": "SNOMEDCT:44591005", "d": []}]}
{"type": "biolink:Cell", "ic": "81.247621244257502", "identifiers": [{"i": "CL:0001031", "l": "cerebellar granule cell", "d": ["An excitatory granule cell with a soma located in the granular layer of cerebellar cortex. A mature cerebellar granule cell has short dendrites with a characteristic claw-like appearance and a long axon that ascends to the molecular layer where it bifurcates (except in non-teleost fish, where it does not bifurcate) and extends mediolaterally to form parallel fibers."]}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "UMLS:C1708921", "l": "Malignant Thyrotroph Cell", "d": []}, {"i": "NCIT:C45948", "l": "Malignant Thyrotroph Cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2333606", "l": "Transitional myocyte of posterior division of left branch of atrioventricular bundle", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2338017", "l": "Neuron of retina", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1979645", "l": "Blasts.CD33+CD34+", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1148323", "l": "Cells.CD20+CD25+/100 cells", "d": []}]}
{"type": "biolink:Cell", "ic": "83.023198044254755", "identifiers": [{"i": "UMLS:C1519111", "l": "Round Cell with Primitive Myoblastic Differentiation", "d": []}, {"i": "NCIT:C36951", "l": "Round Cell with Primitive Myoblastic Differentiation", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:4023089", "l": "nest basket cell", "d": ["A basket cell which has simpler dendritic arbors (compared to small or large basket cells), and an axonal plexus of intermediate density, composed of a few long, smooth axonal branches."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0883468", "l": "CD16+CD56+ cell", "d": []}, {"i": "SNOMEDCT:732275003", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1525454", "l": "Cells.CD2+CD3+", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1440324", "l": "Cells.CD49d", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2328464", "l": "Fibroblast of connective tissue of nonglandular part of prostate", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5666893", "l": "Autologous Anti-CD19 CAR-expressing T-lymphocytes IC19/1563", "d": []}, {"i": "NCIT:C182623", "l": "Autologous Anti-CD19 CAR-expressing T-lymphocytes IC19/1563", "d": ["preparation of autologous T-lymphocytes that have been genetically modified to express a chimeric antigen receptor (CAR) that targets the human tumor associated antigen (TAA) CD19, with potential immunostimulating and antineoplastic activities. Upon administration, autologous anti-CD19 CAR-expressing T-lymphocytes IC19/1563 bind to and induce selective toxicity against CD19-expressing tumor cells. The CD19 antigen is a B-cell-specific cell surface antigen expressed in all B-cell lineage malignancies."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5708224", "l": "Autologous Tumor-infiltrating Lymphocytes-Central Memory T-cells", "d": []}, {"i": "NCIT:C189071", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4038496", "l": "Cells.aneuploid.G2 phase population 2", "d": []}]}
{"type": "biolink:Cell", "ic": "90.82444074280258", "identifiers": [{"i": "CL:1000343", "l": "paneth cell of epithelium of small intestine", "d": ["A paneth cell that is part of the epithelium of small intestine."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1440376", "l": "CDA Cells", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1267824", "l": "T lymphocyte positive for both CD4 antigen and CD45RA antigen", "d": []}, {"i": "SNOMEDCT:115403000", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C2348359", "l": "EGFRBi-Armed Autologous T Cells", "d": []}, {"i": "NCIT:C71536", "l": "EGFRBi-Armed Autologous T Cells", "d": ["Autologous activated T cells, loaded with a bispecific antibody produced by heteroconjugation of anti-CD3 and anti-epidermal growth factor receptor (EGFR) monoclonal antibodies, with potential antineoplastic activity. Binding of EGFRBi-armed autologous activated T cells to EGFR-positive tumor cells may result in increased T cell-mediated cytotoxicity towards tumor cells expressing EGFR.  Arming activated T cells with this bispecific antibody may significantly increase T cell secretion of anti-tumor associated cytokines such as IL2, RANTES, IFN-gamma, and TNF-alpha."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0000350", "l": "amnioserosal cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1254552", "l": "Band Form Leukocytes", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:3000003", "l": "sympathetic cholinergic neuron", "d": ["Sympathetic cholinergic neuron."]}]}
{"type": "biolink:Cell", "ic": "68.203304431560539", "identifiers": [{"i": "CL:0008028", "l": "visual system neuron", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0000420", "l": "syncytial epithelial cell", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1135970", "l": "Theca lutein cell", "d": []}, {"i": "NCIT:C33761", "l": "Theca Lutein Cell", "d": ["A cell of the corpus luteum that is derived from the inner layer of the sheath surrounding the graafian follicle."]}]}
{"type": "biolink:Cell", "ic": "86.236661114203869", "identifiers": [{"i": "CL:0000119", "l": "cerebellar Golgi cell", "d": ["Large intrinsic neuron located in the granule layer of the cerebellar cortex that extends its dendrites into the molecular layer where they receive contact from parallel fibers. The axon of the Golgi cell ramifies densely in the granule layer and enters into a complex arrangement with mossy fiber terminals and granule cell dendrites to form the cerebellar glomerulus. Llinas, Walton and Lang. In The Synaptic Organization of the Brain. 5th ed. 2004."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0229604", "l": "Reticuloendothelial cell", "d": []}, {"i": "SNOMEDCT:27604002", "d": []}]}
{"type": "biolink:Cell", "ic": "41.727217637925072", "identifiers": [{"i": "CL:0000066", "l": "epithelial cell", "d": ["A cell that is usually found in a two-dimensional sheet with a free surface. The cell has a cytoskeleton that allows for tight cell to cell contact and for cell polarity where apical part is directed towards the lumen and the basal part to the basal lamina."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1179873", "l": "Myocyte of atrioventricular node", "d": []}]}
{"type": "biolink:Cell", "ic": "92.728541327098611", "identifiers": [{"i": "CL:0004220", "l": "flag amacrine cell", "d": ["An amacrine cell with a small, asymteric dendritic field."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5557204", "l": "Autologous Anti-CD4 CAR T-cells LB1901", "d": []}, {"i": "NCIT:C181700", "l": "Autologous Anti-CD4 CAR T-cells LB1901", "d": ["A preparation of autologous T-lymphocytes that have been genetically modified and transduced with a lentiviral vector expressing a chimeric antigen receptor (CAR) targeting the tumor-associated antigen (TAA) CD4, with potential immunostimulating and antineoplastic activities. Upon administration, autologous anti-CD4 CAR T-cells LB1901 target and bind to CD4-expressing tumor cells, thereby inducing selective toxicity in CD4-expressing tumor cells. CD4 antigen is expressed in CD4-positive T-cell lymphomas."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:1001287", "l": "outer medulla vasa recta descending limb cell", "d": []}]}
{"type": "biolink:Cell", "ic": "81.247621244257502", "identifiers": [{"i": "CL:0001051", "l": "CD4-positive, CXCR3-negative, CCR6-negative, alpha-beta T cell", "d": ["A CD4-positive, alpha-beta T cell that has the phenotype CXCR3-negative, CCR6-negative."]}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "UMLS:C1511762", "l": "Mouse Dendritic Cell", "d": []}, {"i": "NCIT:C22596", "l": "Mouse Dendritic Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C3831436", "l": "Autologous iC9-GD2-CAR-expressing VZV-specific T Lymphocytes", "d": []}, {"i": "NCIT:C111989", "l": "Autologous iC9-GD2-CAR-expressing VZV-specific T Lymphocytes", "d": ["Genetically modified, autologous varicella zoster virus (VZV)-specific T-lymphocytes transduced with a retroviral vector encoding a chimeric antigen receptor (CAR) specific for the disialoganglioside GD2, which contains the signaling domains for the co-stimulatory molecules CD28 and CD134 (OX-40), and the suicide gene, inducible caspase 9 (iCasp9 or iC9), with potential immunomodulating and antineoplastic activities. Upon intravenous administration, iC9-GD2-CD28-OX40-expressing T lymphocytes target the GD2 antigen on tumor cells for selective toxicity against GD2-expressing tumor cells. iCasp9 consists of a full-length caspase 9, including its caspase recruitment domain, linked to a human FK506 drug-binding domain with an F36V mutation (FKBP12-F36V). If the administered T cells lead to unacceptable side effects, the chemical homodimerizer AP1903 can be administered, which binds to the FKBP12-F36V drug binding domain, activates caspase 9, and results in apoptosis of the administered T-cells. Expression of the iCasp9 gene in T cells for adoptive transfer increases safety and broadens the scope for their clinical applications. The tumor associated antigen GD2 is overexpressed on the surface of almost all tumors of neuroectodermal origin. OX40 and CD28, both T-cell surface-associated co-stimulatory molecules, are required for full T-cell activation. An additional VZV vaccine can be administered to increase T-cell activity."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1267851", "l": "Lymphoblast positive for CD7 antigen", "d": []}, {"i": "SNOMEDCT:117537006", "d": []}]}
{"type": "biolink:Cell", "ic": "92.728541327098611", "identifiers": [{"i": "UMLS:C1708923", "l": "Malignant Transitional Cell with Eccentrically Placed Large Nucleus and Small Nucleolus", "d": []}, {"i": "NCIT:C54555", "l": "Malignant Transitional Cell with Eccentrically Placed Large Nucleus and Small Nucleolus", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0444641", "l": "Synovial fluid cells", "d": []}, {"i": "SNOMEDCT:264380007", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1182626", "l": "Epithelial cell of paranasal sinus part of viscerocranial mucosa", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1507327", "l": "Cells.FLAER", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5216253", "l": "Lymphocytes|NCnc|Pt|Periton fld", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2327682", "l": "Chandelier cell of cerebral cortex", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5447541", "l": "Autologous HER2-targeted Dual-switch CAR-T Cells BPX-603", "d": []}, {"i": "NCIT:C176990", "l": "Autologous HER2-targeted Dual-switch CAR-T Cells BPX-603", "d": ["A preparation of autologous T-lymphocytes that express a chimeric antigen receptor (CAR) for the human epidermal growth factor receptor 2 (EGFR2; HER2; HER-2) and a dual-switch composed of chemical inducer of dimerization (CID)-inducible co-activation domain MyD88/CD40 (inducible MC; iMC), in which both the MyD88 and CD40 lack their extracellular domains, and an inducible caspase 9 (iCasp9) safety switch (CaspaCIDe), consisting of the CID-binding domain coupled to the signaling domain of caspase-9, with potential immunomodulating and antineoplastic activities. Upon administration of autologous HER2-targeted dual-switch CAR-T cells BPX-603, the T-cells target and bind to HER2-expressing cancer cells. Upon subsequent administration of the CID agent rimiducid (AP1903), this agent targets and binds to the drug binding domain of iMC and activates iMC, which leads to the activation of both CD40- and MyD88-mediated signal transduction pathways. This allows for enhanced T-cell proliferation, persistence and resistance to T-cell exhaustion and upregulation of immunomodulatory cytokines within the tumor microenvironment (TME). This increases the anti-tumor activity of the administered T-cells, compared to T-cells without the iMC activation-switch. As these T-cells are engineered to only be fully activated by binding to both the HER2 antigen and rimiducid, T-cell proliferation, activity and toxicity can be controlled by adjusting the dose of rimiducid, thereby preventing uncontrolled T-cell activation which increases the safety of the administered T-cells. The binding of rimiducid to the CID binding domain of iCasp9 results in the cross-linking and dimerization of iCasp9, which causes its activation. This results in the induction of caspase-mediated apoptosis of the transduced cells and allows for the removal of inappropriately activated cells, thereby preventing toxicity of the administered cells. HER2, a tumor-associated antigen (TAA), plays a key role in tumor cell proliferation and tumor vascularization."]}]}
{"type": "biolink:Cell", "ic": "90.82444074280258", "identifiers": [{"i": "CL:0002668", "l": "type 4 otic fibrocyte", "d": ["An otic fibrocyte that is lateral to the basilar membrane and anchoris it to the lateral wall."]}]}
{"type": "biolink:Cell", "ic": "86.236661114203869", "identifiers": [{"i": "UMLS:C1513937", "l": "Neoplastic Chondroblast", "d": []}, {"i": "NCIT:C36985", "l": "Neoplastic Chondroblast", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4246841", "l": "Vagal neural crest cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5419454", "l": "Autologous CD34+-enriched HSPCs Transduced with VSV-G Encoding IFN-a2", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5216296", "l": "Neutrophils|NCnc|Pt|Synv fld", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1717666", "l": "Cells.CD4+CD45RA+CD45RB+CD45RC+", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5178284", "l": "Prolymphocytes | Blood | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5237228", "l": "Zevorcabtagene autoleucel", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0003048", "l": "L cone cell", "d": ["A cone cell that detects long wavelength light. Exact peak of spectra detected differs between species. In humans, spectra peaks at 564-580 nm."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5206845", "l": "Autologous Anti-CD19 CAR-CD28 T-cells ET019002", "d": []}, {"i": "NCIT:C162856", "l": "Autologous Anti-CD19 CAR-CD28 T-cells ET019002", "d": ["A preparation of autologous T-lymphocytes that have been transduced with a lentiviral vector to express a chimeric antigen receptor (CAR) consisting of a single chain variable fragment (scFv) of anti-CD19, coupled to the costimulatory domain of CD28, with potential immunostimulating and antineoplastic activities. Upon transfusion, the autologous anti-CD19 CAR-CD28 T-cells ET019002 target, bind to, and induce selective toxicity in CD19-expressing B-cells. The CD19 antigen is a B-cell-specific cell surface antigen expressed in all B-cell lineage malignancies."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0000427", "l": "GLR cell", "d": ["A scaffolding cell type found in C. elegans, this cell plays a supportive role to the muscle arms. May also have an endocrine role."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1267830", "l": "T lymphocyte positive for CD16 antigen and CD57 antigen", "d": []}, {"i": "SNOMEDCT:115416000", "d": []}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "CL:0002214", "l": "type IIa muscle cell", "d": ["A type II muscle cell that contains large amounts of myoglobin, has many mitochondria and very many blood capillaries. Type II A cells are red, have a very high capacity for generating ATP by oxidative metabolic processes, split ATP at a very rapid rate, have a fast contraction velocity and are resistant to fatigue."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5690735", "l": "Mucosa-Associated Lymphoid Tissue M Cells", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157563", "l": "CD41a cells | Blood | Cell markers", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1267799", "l": "CYCD3+ lymphocyte", "d": []}, {"i": "SNOMEDCT:117503003", "d": []}]}
{"type": "biolink:Cell", "ic": "92.728541327098611", "identifiers": [{"i": "CL:0002241", "l": "pulmonary interstitial fibroblast", "d": ["A fibroblasts found in interstitial spaces in the pulmonary tract. Greater numbers of these cells are found in idiopathic pulmonary fibrosis."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1440358", "l": "Cells.CD8+CD56+", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5554957", "l": "Anti-CLDN6 CAR T-cells", "d": []}, {"i": "NCIT:C178332", "l": "Anti-CLDN6 CAR T-cells", "d": ["A preparation of T-lymphocytes expressing a chimeric antigen receptor (CAR) targeting the cell surface protein claudin 6 (CLDN6), with potential immunostimulating and antineoplastic activities. Upon administration, the anti-CLDN6 CAR T-cells specifically target and bind to CLDN6-expressing tumor cells, thereby selectively lysing CLDN6-expressing tumor cells. CLDN-6, a transmembrane tight-junction protein and embryonic antigen, is overexpressed on a variety of tumor cells but is not expressed on normal, healthy adult cells."]}]}
{"type": "biolink:Cell", "ic": "48.206525333022121", "identifiers": [{"i": "CL:0000842", "l": "mononuclear cell", "d": ["A leukocyte with a single non-segmented nucleus in the mature form."]}]}
{"type": "biolink:Cell", "ic": "81.247621244257502", "identifiers": [{"i": "CL:1001428", "l": "bladder urothelial cell", "d": ["A urothelial cell that is part of the urothelium of the urinary bladder."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5382576", "l": "Cells.CD8.PMA+ionomycin stimulated gamma interferon producing", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4324226", "l": "CD43+ B lymphocyte", "d": []}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "CL:0005001", "l": "iridoblast", "d": ["A non-terminally differentiated cell that originates from the neural crest and differentiates into an iridophore."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:1000473", "l": "myoepithelial cell of quarternary lactiferous duct", "d": ["A myoepithelial cell that is part of the quarternary lactiferous duct."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5170952", "l": "Leukocytes other | Cerebral spinal fluid | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5184824", "l": "Variant lymphocytes | Synovial fluid | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "ic": "66.748105804263417", "identifiers": [{"i": "CL:0000240", "l": "stratified squamous epithelial cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5161795", "l": "Cytoplasmic CD179a blasts | Blood | Cell markers", "d": []}]}
{"type": "biolink:Cell", "ic": "85.457082654197222", "identifiers": [{"i": "UMLS:C1710606", "l": "Vacuolated Malignant Fibroblast", "d": []}, {"i": "NCIT:C49030", "l": "Vacuolated Malignant Fibroblast", "d": []}]}
{"type": "biolink:Cell", "ic": "90.82444074280258", "identifiers": [{"i": "UMLS:C1515214", "l": "Tara ES Cell Line", "d": []}, {"i": "NCIT:C20280", "l": "Tara ES Cell Line", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:1000804", "l": "kidney outer medulla interstitial cell", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5707274", "l": "Autologous Anti-B7-H3 CAR T Cells CAR.B7-H3T", "d": []}, {"i": "NCIT:C187657", "l": "Autologous Anti-B7-H3 CAR T Cells CAR.B7-H3T", "d": ["A preparation of autologous T-lymphocytes that have been genetically engineered to express a chimeric antigen receptor (CAR) targeting the immunoregulatory protein B7-homologue 3 (B7-H3, CD276) and containing, as of yet undisclosed co-stimulatory signaling domains, with potential immunostimulating and antineoplastic activities. Upon infusion back into the patient, autologous anti-B7-H3 CAR T cells CAR.B7-H3T target and bind to B7-H3-expressing tumor cells, thereby inducing selective toxicity in B7-H3-expressing tumor cells. B7-H3, a type I transmembrane protein and a member of the B7 co-stimulatory protein superfamily, is overexpressed on certain tumor cell types and on various immune cells. It is a negative regulator of the T-cell activation and its overexpression plays a key role in tumor cell invasion and metastasis."]}]}
{"type": "biolink:Cell", "ic": "66.408607444211199", "identifiers": [{"i": "UMLS:C1709184", "l": "Neoplastic Lipocyte", "d": []}, {"i": "NCIT:C48683", "l": "Neoplastic Lipocyte", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C4724860", "l": "Autologous Mesothelin-specific CAR-T Cells", "d": []}, {"i": "NCIT:C148160", "l": "Autologous Mesothelin-specific CAR-T Cells", "d": ["Genetically modified, autologous T-lymphocytes transduced with a gene encoding a chimeric antigen receptor (CAR) specific for the human tumor-associated antigen (TAA) mesothelin, with potential immunomodulating and antineoplastic activities. After isolation, transduction, expansion in culture, and reintroduction into the patient, the autologous mesothelin-specific CAR-T cells specifically target and kill mesothelin-expressing tumor cells. Mesothelin, a cell surface glycoprotein involved in cell adhesion, is overexpressed in a variety of cancer cell types."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5216312", "l": "Polymorphonuclear cells|NCnc|Pt|Plr fld", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2328960", "l": "Hippocampal interneuron", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C4733635", "l": "Autologous CD30CAR-CD28-CD3zeta-expressing T-Lymphocytes", "d": []}, {"i": "NCIT:C155294", "l": "Autologous CD30CAR-CD28-CD3zeta-expressing T-Lymphocytes", "d": ["A preparation of autologous T-lymphocytes (ATL) that have been transduced with the retroviral vector SFG, a Moloney murine leukemia (Mo-MuLV) virus-based vector, encoding a chimeric antigen receptor (CAR) composed of a single chain single-chain variable fragment (scFv) directed against the CD30 antigen (CAR.CD30) and linked, via the spacer human IgG1 immunoglobulin heavy constant region (hinge-CH2CH3 region), to the co-stimulatory domains of CD28 and the zeta chain of the TCR/CD3 complex (CD3-zeta) (CD28zeta), with potential immunostimulating and antineoplastic activities. Upon administration, the autologous CD30CAR-CD28-CD3zeta-expressing T-lymphocytes specifically recognize and bind to CD30-expressing tumor cells, resulting in specific T-cell-mediated tumor cell lysis. CD30, a cell surface receptor and a member of the tumor necrosis factor (TNF) receptor superfamily, is transiently expressed on activated lymphocytes and is constitutively expressed in hematologic malignancies."]}]}
{"type": "biolink:Cell", "ic": "79.541110464886842", "identifiers": [{"i": "UMLS:C1519449", "l": "Spermatogenic Cell", "d": []}, {"i": "NCIT:C33582", "l": "Spermatogenic Cell", "d": ["A cell that produces sperm."]}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "CL:0013000", "l": "forebrain radial glial cell", "d": []}]}
{"type": "biolink:Cell", "ic": "92.728541327098611", "identifiers": [{"i": "UMLS:C4727588", "l": "Neoplastic Corticotroph Cell with Abundant Secretory Granules", "d": []}, {"i": "NCIT:C154337", "l": "Neoplastic Corticotroph Cell with Abundant Secretory Granules", "d": ["A neoplastic basophilic PAS-positive and ACTH-positive cell with an abundance of secretory granules seen at the ultrastructural level."]}]}
{"type": "biolink:Cell", "ic": "92.728541327098611", "identifiers": [{"i": "CL:1001435", "l": "periglomerular cell", "d": ["The small neuron in the glomerular layer of the olfactory bulb whose dendrites arborize within a glomerulus, where it receives synaptic input from olfactory receptor cell axon terminals, and also engages in dendrodendritic interactions with mitral and tufted cell dendrites; uses both GABA and dopamine as a neurotransmitter."]}]}
{"type": "biolink:Cell", "ic": "88.140761698499901", "identifiers": [{"i": "UMLS:C0037857", "l": "Spermatid", "d": []}, {"i": "NCIT:C12604", "l": "Spermatid", "d": ["An immature male germ cell that is formed by meiotic division of a secondary spermatocyte. Spermatids develop into spermatozoa."]}, {"i": "MESH:D013087", "l": "Spermatids", "d": []}, {"i": "SNOMEDCT:38326003", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002592", "l": "smooth muscle cell of the coronary artery", "d": ["A smooth muscle cell of the coronary artery."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5446540", "l": "Lymphodepleted Autologous CD4-directed CAR T Cells", "d": []}, {"i": "NCIT:C175459", "l": "Lymphodepleted Autologous CD4-directed CAR T Cells", "d": ["A preparation of autologous peripheral blood T-lymphocytes (PBTLs) that have been genetically modified to express a chimeric antigen receptor (CAR) specific for the T-cell surface antigen CD4, administered with lymphodepletion, with potential immunostimulating and antineoplastic activities. Upon administration, lymphodepleted autologous CD4-directed CAR T cells specifically recognize and kill CD4-expressing tumor cells. CD4, a tumor-associated antigen (TAA), is overexpressed in various lymphomas, including peripheral T-cell lymphoma, angioimmunoblastic T-cell lymphoma and anaplastic large cell lymphoma."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:1000714", "l": "kidney cortex collecting duct principal cell", "d": []}]}
{"type": "biolink:Cell", "ic": "62.314514074781378", "identifiers": [{"i": "UMLS:C1514039", "l": "Neoplastic Myeloid Cell", "d": []}, {"i": "NCIT:C41063", "l": "Neoplastic Myeloid Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C4329343", "l": "Anti-hCD70-CAR Retroviral Vector-transduced Autologous PBLs", "d": []}, {"i": "NCIT:C129593", "l": "Anti-hCD70-CAR Retroviral Vector-transduced Autologous PBLs", "d": ["A preparation of autologous human peripheral blood lymphocytes (PBLs) transduced with a retroviral vector encoding for a T-cell chimeric antigen receptor (CAR) gene specific for the human cluster of differentiation 70 (CD70), with potential immunostimulatory and antineoplastic activities. Autologous PBLs from a patient with CD70-positive cancer are transduced with a retroviral vector that encodes the CAR gene specific for CD70. After expansion in culture and reintroduction into the patient, anti-hCD70-CAR retroviral vector-transduced autologous PBLs bind to the CD70 antigen on tumor cell surfaces; subsequently, CD70-expressing tumor cells are lysed. CD70, the ligand for the costimulatory receptor CD27, is overexpressed on the surfaces of various cancer cell types."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5392106", "l": "HaCaT Cells", "d": []}, {"i": "MESH:D000084282", "l": "HaCaT Cells", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0314596", "l": "Spleen colony-forming unit", "d": []}, {"i": "SNOMEDCT:445288000", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1180271", "l": "Myoepithelial cell of lactiferous alveolus", "d": []}]}
{"type": "biolink:Cell", "ic": "69.928990792433112", "identifiers": [{"i": "CL:0000894", "l": "DN1 thymic pro-T cell", "d": ["A pro-T cell that has the phenotype CD4-negative, CD8-negative, CD44-positive, and CD25-negative."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0221284", "l": "Leptocyte", "d": []}, {"i": "SNOMEDCT:112660002", "d": []}, {"i": "SNOMEDCT:259686006", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4733231", "l": "MFE23 scFv-expressing autologous anti-CEA MFEz T lymphocytes", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5555558", "l": "Anti-GD2/PSMA/CD276 4SCAR-expressing T-cells", "d": []}, {"i": "NCIT:C179257", "l": "Anti-GD2/PSMA/CD276 4SCAR-expressing T-cells", "d": ["A preparation of  T-cells that are genetically engineered to express fourth generation chimeric antigen receptors (4SCARs) targeting the three tumor-associated antigens (TAAs) prostate-specific membrane antigen (PSMA), disialoganglioside (GD2), and the immune checkpoint molecule protein B7-homologue 3 (B7-H3, CD276), coupled to the costimulatory signaling domains CD28, CD137, CD27 and the zeta chain of the T-cell receptor (CD3zeta; CD3z), and fused with the suicide gene inducible caspase 9 (iCasp9), with potential immunostimulating and antineoplastic activities. Upon administration, the anti-GD2/PSMA/CD276-4SCAR-expressing T-cells are directed to and induce selective toxicity in GD2-, PSMA- and CD276-expressing tumor cells. iCasp9 consists of a human FK506 drug-binding domain with an F36V mutation (FKBP12-F36V) linked to human caspase 9. If the administered T-cells lead to unacceptable side effects, the chemical homodimerizer AP1903 can be administered. AP1903 binds to the drug binding FKBP12-F36V domain and induces activation of caspase 9, which results in the apoptosis of the administered T-cells and enhances safety of this agent. PSMA, a type II transmembrane protein, is expressed on the membrane of prostatic epithelial cells and overexpressed on prostate tumor cells as well as a variety of other solid tumors, including brain tumor, neuroblastoma (NB) and some lymphoma tumor tissues. CD276, a type I transmembrane protein and a member of the B7 co-stimulatory protein superfamily, is highly expressed on many solid tumors including NB. It is a negative regulator of the T-cell activation and plays a key role in tumor evasion. GD2 is overexpressed on the surface of NB cells and by other neuroectoderm-derived neoplasms, while it is minimally expressed on normal cells. CD28, CD137 and CD27, T-cell surface-associated co-stimulatory molecules, are required for full T-cell activation and enhance both proliferation of T-cells and antitumor activity."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5555588", "l": "CD8-depleted Non-engrafting HLA-mismatched Unrelated Donor Lymphocytes", "d": []}, {"i": "NCIT:C179290", "l": "CD8-depleted Non-engrafting HLA-mismatched Unrelated Donor Lymphocytes", "d": ["A preparation of allogeneic lymphocytes from an HLA-mismatched donor that have been selectively depleted of CD8+ T-cells, with potential T-cell reconstitution purposes. Upon infusion, the donor-derived CD8+-depleted lymphocytes may increase the levels of CD4+ T-cells (Teffs) and promote T-cell reconstitution. The infusion of donor lymphocytes depleted of CD8 T-cells may reduce the risk of inducing graft-versus-host disease (GVHD) compared to the infusion of non-CD8-depleted T-cells."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2950201", "l": "Type D cell of duodenum", "d": []}]}
{"type": "biolink:Cell", "ic": "58.709983342611608", "identifiers": [{"i": "CL:0000667", "l": "collagen secreting cell", "d": ["An extracellular matrix secreting cell that secretes collagen."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0227531", "l": "Ito Cells", "d": []}, {"i": "SNOMEDCT:39977009", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5216283", "l": "Myelocytes|NCnc|Pt|Bld", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5666975", "l": "Autologous Anti-GPC3 CAR T Cells BOXR1030", "d": []}, {"i": "NCIT:C185392", "l": "Autologous Anti-GPC3 CAR T Cells BOXR1030", "d": ["A preparation of autologous T-lymphocytes that have been genetically modified to express a chimeric antigen receptor (CAR) specific for glypican-3 (GPC3) and glutamic-oxaloacetic transaminase 2 (GOT2) transgene, with potential immunostimulating and antineoplastic activities. Upon administration, autologous anti-GPC3 CAR T cells BOXR1030 specifically targets and binds to GPC3-expressing tumor cells, resulting in tumor cell lysis. GPC3, a heparan sulfate proteoglycan and a member of the glypican family, is overexpressed on certain tumor cell types while minimally expressed on normal, healthy cells; GPC3 plays an important role in cellular proliferation and differentiation. The inclusion of GOT2, a mitochondrial enzyme that plays an important role in cellular metabolism, may improve T-cell metabolic function and anti-tumor activity."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1440248", "l": "Cells.CD11c+CD25+", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2340535", "l": "Spiny stellate cell of cerebral cortex", "d": []}]}
{"type": "biolink:Cell", "ic": "67.782924002860781", "identifiers": [{"i": "CL:0000064", "l": "ciliated cell", "d": ["A cell that has a filiform extrusion of the cell surface."]}]}
{"type": "biolink:Cell", "ic": "92.728541327098611", "identifiers": [{"i": "CL:0000634", "l": "Claudius cell", "d": ["A cuboidal cell which along with Boettcher's cells form the floor of the external spiral sulcus, external to the organ of Corti."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1511468", "l": "CY82", "d": []}, {"i": "NCIT:C20242", "l": "CY82", "d": ["Provider: CyThera, Inc., San Diego, CA. No information from provider. This cell line meets the criteria for the use of human embryonic stem cells by federally funded researchers."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C3896577", "l": "LMP1/BARF1/EBNA1-specific Cytotoxic T-lymphocytes", "d": []}, {"i": "NCIT:C118956", "l": "LMP1/BARF1/EBNA1-specific Cytotoxic T-lymphocytes", "d": ["A preparation of allogeneic cytotoxic T-lymphocytes (CTL) made specifically reactive to three Epstein-Barr virus (EBV) proteins, latent membrane protein (LMP) 1, BamH1-A rightward frame-1 (BARF1) and EBV nuclear antigen 1 (EBNA1), with potential antineoplastic activity. Administration of LMP1/BARF1/ EBNA1-specific CTLs to patients with LMP1/BARF1/EBNA1-positive tumors may result in a specific CTL response against the tumor cells expressing these antigens, which can result in both cell lysis and the inhibition of tumor cell proliferation. LMP1, BARF1 and EBNA1 are expressed in various, EBV-associated malignancies, including nasopharyngeal cancer and EBV-positive Hodgkin lymphoma."]}]}
{"type": "biolink:Cell", "ic": "78.96520244130248", "identifiers": [{"i": "CL:0000465", "l": "cardioblast (sensu Arthropoda)", "d": ["A precursor of the cells that form the dorsal vessel of arthropods."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C3900058", "l": "Allogeneic Multivirus-specific Cytotoxic T Lymphocytes", "d": []}, {"i": "NCIT:C115107", "l": "Allogeneic Multivirus-specific Cytotoxic T Lymphocytes", "d": ["A population of closely human leukocyte antigen (HLA)-matched, donor-derived cytotoxic T lymphocytes (CTLs) that are specifically reactive towards five viruses, Epstein-Barr virus (EBV), cytomegalovirus (CMV), adenovirus (AdV), human herpesvirus 6 (HHV6), and human polyomavirus type I (BKV), with potential antiviral activity. Infusion of the multivirus-specific CTLs into allogeneic hematopoietic stem cell transplant (HSCT) recipients provides virus-specific cellular immunity and causes specific anti-viral effects against active viral infections. The administered CTLs also prevent EBV, CMV, AdV, HHV6, and BKV reactivation and infection as well as inhibiting viral-associated diseases in immunocompromised patients. The allogeneic multivirus-specific CTLs may also provide cellular immunity towards the human polyomavirus type II (JC virus; JCV), which is highly homologous to BKV."]}]}
{"type": "biolink:Cell", "ic": "64.898660913853604", "identifiers": [{"i": "UMLS:C0162597", "l": "Stromal Cells", "d": []}, {"i": "NCIT:C12571", "l": "Stromal Cell", "d": ["Connective tissue cells found in the tissue stroma of any organ."]}, {"i": "MESH:D017154", "l": "Stromal Cells", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5704896", "l": "Skysona", "d": []}]}
{"type": "biolink:Cell", "ic": "51.829020935813723", "identifiers": [{"i": "UMLS:C0009781", "l": "Connective Tissue Cells", "d": []}, {"i": "NCIT:C12555", "l": "Connective and Soft Tissue Cell", "d": ["A non-epithelial cell of mesodermal origin that is found in mesenchymal tissue and functions to support, surround, or protect other structures or organs in the body."]}, {"i": "MESH:D003239", "l": "Connective Tissue Cells", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0001280", "l": "Armed macrophage", "d": []}, {"i": "SNOMEDCT:86373002", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0009008", "l": "gastrointestinal tract (lamina propria) macrophage of large intestine", "d": ["A macrophage which is resident in the lamina propria of the large intestine."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1182634", "l": "Pancreatic Polypeptide-Secreting Cells", "d": []}, {"i": "MESH:D050418", "l": "Pancreatic Polypeptide-Secreting Cells", "d": []}]}
{"type": "biolink:Cell", "ic": "75.751739371353352", "identifiers": [{"i": "UMLS:C1512107", "l": "Dysplastic Neutrophil", "d": []}, {"i": "NCIT:C37031", "l": "Dysplastic Neutrophil", "d": []}]}
{"type": "biolink:Cell", "ic": "80.869303025598512", "identifiers": [{"i": "CL:0000519", "l": "phagocyte (sensu Nematoda and Protostomia)", "d": ["A phagocyte from organisms in the Nematoda or Protostomia clades."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0682550", "l": "silver-staining cell", "d": []}]}
{"type": "biolink:Cell", "ic": "73.476395680690302", "identifiers": [{"i": "CL:2000049", "l": "primary motor cortex pyramidal cell", "d": ["Any pyramidal cell that is part of a primary motor cortex."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002176", "l": "secondary follicular cell of ovary", "d": ["A cell of a secondary follicile within the ovary."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:1001582", "l": "lateral ventricle neuron", "d": ["Neuron of lateral ventricle."]}]}
{"type": "biolink:Cell", "ic": "88.140761698499901", "identifiers": [{"i": "UMLS:C1708248", "l": "Gonadotrophs", "d": []}, {"i": "NCIT:C32691", "l": "Gonadotroph Cell", "d": ["An endocrine cell of the adenohypophysis that affects certain cells of the ovary or testis."]}, {"i": "MESH:D052681", "l": "Gonadotrophs", "d": []}, {"i": "SNOMEDCT:44490009", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1267911", "l": "Lymphocyte positive for both CD34 antigen and HLA-DR antigen", "d": []}, {"i": "SNOMEDCT:117581003", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5418870", "l": "Anti-CD19/CD22 CAR NK Cells", "d": []}, {"i": "NCIT:C170904", "l": "Anti-CD19/CD22 CAR NK Cells", "d": ["A preparation of natural killer (NK) cells engineered to express a chimeric antigen receptor (CAR) specific for the tumor-associated antigens (TAAs) cluster of differentiation 19 (CD19) and CD22, with potential immunostimulating and antineoplastic activities. Upon administration, the anti-CD19/CD22 CAR-NK cells target and bind to CD19 and CD22 expressed on the surface of tumor cells. This induces selective toxicity in tumor cells expressing these TAAs. CD19 and CD22, both transmembrane phosphoglycoproteins expressed on the surface of cells in the B lineage, are often overexpressed on malignant B-cells. By simultaneously targeting two B-cell antigens, this preparation may minimize relapse due to single antigen loss in patients with B-cell malignancies."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002581", "l": "perirenal preadipocyte", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5171864", "l": "Macrophages | Body fluid | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C4684462", "l": "Autologous CD4 and CD8 Positive Truncated CD19-expressing Antigen Presenting T-cells", "d": []}, {"i": "NCIT:C142205", "l": "Autologous CD4 and CD8 Positive Truncated CD19-expressing Antigen Presenting T-cells", "d": ["A preparation of ex vivo expanded, autologous CD4 and CD8 positive antigen presenting T-cells (T-APCs), genetically modified with a transgene encoding a truncated form of human cluster of differentiation 19 (CD19t), with potential immunostimulating activity. Upon infusion, autologous CD19t-expressing T-APCs may stimulate the proliferation and activation of preadministered therapeutic CD19-targeted chimeric antigen receptor T-cells (CAR-T). This may both improve the persistence of the therapeutic CAR-T-cells and prevent relapse in patients with CD19 positive leukemia or lymphoma. CD19 is a B-cell specific cell surface antigen that is expressed in all B-cell lineage malignancies."]}]}
{"type": "biolink:Cell", "ic": "50.392433057336405", "identifiers": [{"i": "UMLS:C1514011", "l": "Neoplastic Lymphocyte", "d": []}, {"i": "NCIT:C36988", "l": "Neoplastic Lymphocyte", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1514965", "l": "Mouse Stem Cell", "d": []}, {"i": "NCIT:C22563", "l": "Mouse Stem Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:2000087", "l": "dentate gyrus of hippocampal formation basket cell", "d": ["Any basket cell that is part of a dentate gyrus of hippocampal formation."]}]}
{"type": "biolink:Cell", "ic": "83.552982069901191", "identifiers": [{"i": "CL:4023043", "l": "L5/6 near-projecting glutamatergic neuron of the primary motor cortex", "d": ["A near-projecting glutamatergic neuron with a soma found in layer 5/6 of the primary motor cortex."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5669986", "l": "Autologous Anti-EGFR/Anti-IL13Ralpha2 CAR T-cells", "d": []}, {"i": "NCIT:C185590", "l": "Autologous Anti-EGFR/Anti-IL13Ralpha2 CAR T-cells", "d": ["A preparation of autologous T-lymphocytes engineered to co-express two chimeric antigen receptors (CARs) specific for epidermal growth factor receptor (EGFR) epitope 806 and interleukin-13 receptor alpha 2 (IL13Ra2), with potential immunostimulating and antineoplastic activities. After isolation, transduction, expansion and reintroduction into the patient, the autologous anti-EGFR/anti-IL13Ra2 CAR T-cells are directed to, bind to, and induce selective toxicity in EGFR deletion mutation variant III (EGFRvIII)-expressing and IL13Ra2-expressing tumor cells. EGFRvIII, an in-frame deletion of exons 2-7 in the EGFR gene, is overexpressed by a variety of cancer cell types but absent in normal, healthy cells. It plays a key role in tumor cell proliferation, tumor angiogenesis and resistance to both radio- and chemotherapy. IL13Ra2, a cancer-associated receptor, is overexpressed by a variety of tumor cell types including glioblastoma multiforme (GBM); it is associated with increased invasiveness of tumor cells. The binding of IL13Ra2 to EGFRvIII upregulates the tyrosine kinase activity of EGFRvIII and promotes tumor cell proliferation."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4733633", "l": "Autologous CD19-targeted CAR T Cells JWCAR029", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0000203", "l": "gravity sensitive cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0682543", "l": "cell by staining properties", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4697032", "l": "Cells.CD38+IgM+", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0682517", "l": "animal cell line", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5706544", "l": "LYL 132", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1267955", "l": "Lymphocyte positive for CD62P antigen", "d": []}, {"i": "SNOMEDCT:117396003", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002299", "l": "type-2 epithelial cell of thymus", "d": ["An epithelial cell scattered in the cortex, predominant in the outer cortex with a large pale nucleus and a prominent nucleolus."]}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "CL:0010010", "l": "cerebellar stellate cell", "d": []}]}
{"type": "biolink:Cell", "ic": "78.695011174409487", "identifiers": [{"i": "CL:1001225", "l": "kidney collecting duct cell", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002373", "l": "growth hormone releasing hormone secreting cell", "d": ["A peptide hormone secreting cell that secretes growth hormone releasing hormone."]}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "UMLS:C1513370", "l": "MizMedi ES Cell Line", "d": []}, {"i": "NCIT:C20278", "l": "MizMedi ES Cell Line", "d": []}]}
{"type": "biolink:Cell", "ic": "88.140761698499901", "identifiers": [{"i": "CL:0000772", "l": "immature eosinophil", "d": ["Any of the immature forms of an eosinophil, in which eosinophilic specific granules are present but other phenotypic features of the mature form may be lacking."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1267935", "l": "Lymphocyte positive for CD48 antigen", "d": []}, {"i": "SNOMEDCT:117378007", "d": []}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "UMLS:C1513125", "l": "Meningothelial Cell with Elongated Processes", "d": []}, {"i": "NCIT:C37157", "l": "Meningothelial Cell with Elongated Processes", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157666", "l": "CD8+CD11b+ cells | Blood | Cell markers", "d": []}]}
{"type": "biolink:Cell", "ic": "69.010064724098413", "identifiers": [{"i": "UMLS:C1514015", "l": "Neoplastic Medium-Sized Lymphocyte", "d": []}, {"i": "NCIT:C37004", "l": "Neoplastic Medium-Sized Lymphocyte", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0882768", "l": "Cell positive for CD1 antigen", "d": []}, {"i": "SNOMEDCT:725316009", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1518990", "l": "Periosteal cell", "d": []}, {"i": "NCIT:C33305", "l": "Periosteal Cell", "d": ["A cell of the loose cellular inner layer of the periosteal tissue in the intramembranous ossification of bone"]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0004137", "l": "retinal ganglion cell A2 inner", "d": ["A retinal ganglion A2 cell with dendrites terminating in S4."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2340138", "l": "Hepatic Stellate Cells", "d": []}, {"i": "MESH:D055166", "l": "Hepatic Stellate Cells", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1267988", "l": "Lymphocyte positive for CD102 antigen", "d": []}, {"i": "SNOMEDCT:117428009", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2332989", "l": "Goblet cell of epithelium of small intestine", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5690109", "l": "Cells.LRBA+", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0882849", "l": "Cell positive for CD34 antigen", "d": []}, {"i": "SNOMEDCT:116826008", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157671", "l": "CD8+CD57+ cells | Blood | Cell markers", "d": []}]}
{"type": "biolink:Cell", "ic": "52.118667397421859", "identifiers": [{"i": "UMLS:C0004561", "l": "B-Lymphocytes", "d": []}, {"i": "NCIT:C12474", "l": "B-Lymphocyte", "d": ["Immunologically important lymphocyte that is not thymus-dependent, is either short-lived and naive or long-lived and of memory phenotype, and resembles the bursa-derived lymphocyte of birds in that it is responsible for the production of immunoglobulins."]}, {"i": "MESH:D001402", "l": "B-Lymphocytes", "d": []}, {"i": "SNOMEDCT:112130006", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5418874", "l": "Autologous Anti-CD147 CAR T-cells", "d": []}, {"i": "NCIT:C170913", "l": "Autologous Anti-CD147 CAR T-cells", "d": ["A preparation of autologous activated T cells that have been engineered to express chimeric antigen receptors (CARs) specific for the tumor-associated antigen (TAA) CD147 (Basigin; EMMPRIN; extracellular matrix metalloproteinase inducer; OX47; 5A11), with potential antineoplastic activity. Upon administration back into the patient, the anti-CD147 CAR T-cells target and induce selective cytotoxicity in CD147-expressing tumor cells. CD147, a cell-surface glycoprotein of the immunoglobulin G (IgG) superfamily, is overexpressed in certain human tumors and plays an important role in tumor cell proliferation, migration, progression, and metastasis."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5174096", "l": "Myelocytes | Blood | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "CL:0002137", "l": "type III cell of adrenal cortex", "d": ["A cell in the zona reticularis that produce sex hormones."]}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "UMLS:C0524979", "l": "Enteroendocrine Cell", "d": []}, {"i": "NCIT:C45968", "l": "Enteroendocrine Cell", "d": ["A hormone-secreting cell present in the epithelium of the intestine."]}, {"i": "MESH:D019858", "l": "Enteroendocrine Cells", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:4023164", "l": "globular bushy cell", "d": ["A bushy cell that receives a large number of medium-sized synapses, called modified endbulbs. Globular bushy cells extend to the superior olive on both sides of the brainstem where they give input to the bipolar neurons."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5382575", "l": "Cells.CD8.PMA+ionomycin stimulated CD107a+b expressing", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002445", "l": "Ly49D-negative natural killer cell, mouse", "d": ["A NK1.1-positive T cell that is Ly49D-negative."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0003035", "l": "M6 retinal ganglion cell", "d": ["A monostratified retinal ganglion cell that contains opsin."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0229568", "l": "Adrenal medulllary cell", "d": []}, {"i": "SNOMEDCT:35284004", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1519010", "l": "Mesothelial cell of peritoneum", "d": []}, {"i": "NCIT:C33310", "l": "Peritoneal Mesothelial Cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1440420", "l": "Cells.t(X;18)(q11.2;p11.22)(SS18,SSX2)", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1522260", "l": "Connective Tissue - Fibroblasts (MMHCC)", "d": []}, {"i": "NCIT:C22700", "l": "Mouse Fibroblast", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C3640942", "l": "Recombinant Human MUC1-Oxidized Polymannose-pulsed Autologous Dendritic Cell Vaccine", "d": []}, {"i": "NCIT:C102782", "l": "Recombinant Human MUC1-Oxidized Polymannose-pulsed Autologous Dendritic Cell Vaccine", "d": ["A cancer vaccine containing autologous dendritic cells pulsed with a fusion product of an epitope of human tumor-associated epithelial mucin 1 (MUC1) antigen and the vaccine adjuvant mannan (oxidized mannose), with potential antineoplastic activity. When the modified dendritic cells are returned to the patient, they may stimulate the host immune system to mount a cytotoxic T lymphocyte (CTL) response against tumor cells positive for the MUC1 antigen, resulting in tumor cell lysis. Addition of manna in this vaccine, enhances immune recognition. MUC1 antigen, a high-molecular-weight transmembrane glycoprotein, is overexpressed on many tumor cells."]}]}
{"type": "biolink:Cell", "ic": "75.26123597683771", "identifiers": [{"i": "UMLS:C1514435", "l": "Primitive Mesenchymal Cell", "d": []}, {"i": "NCIT:C36907", "l": "Primitive Mesenchymal Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "46.820649913956068", "identifiers": [{"i": "CL:0000738", "l": "leukocyte", "d": ["An achromatic cell of the myeloid or lymphoid lineages capable of ameboid movement, found in blood or other tissue."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002027", "l": "CD9-positive, CD41-positive megakaryocyte cell", "d": ["A megakaryocyte cell with is CD9-positive and CD41-positive."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5706236", "l": "Autologous Muscle-derived Cells for Gastrointestinal Repair", "d": []}, {"i": "NCIT:C188383", "d": []}]}
{"type": "biolink:Cell", "ic": "77.061101857006449", "identifiers": [{"i": "CL:0002659", "l": "glandular cell of stomach", "d": ["A glandular epithelial cell that is part of the stomach."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1267898", "l": "Lymphocyte positive for both CD25 antigen and CD19 antigen", "d": []}, {"i": "SNOMEDCT:116731001", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5216300", "l": "Nucleated cells|NCnc|Pt|Dial fld", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0333798", "l": "Poikilocyte (cell)", "d": []}, {"i": "SNOMEDCT:397020000", "d": []}]}
{"type": "biolink:Cell", "ic": "90.82444074280258", "identifiers": [{"i": "UMLS:C1710399", "l": "Thymic Epithelial Stem Cell", "d": []}, {"i": "NCIT:C45723", "l": "Thymic Epithelial Stem Cell", "d": ["An epithelial cell that exists in the early fetal thymus that has the capacity to give rise to both cortical and medullary thymic epithelium."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5182777", "l": "TCR gamma delta cells | Blood | Cell markers", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5216237", "l": "Leukocytes|NCnc|Pt|Pericard fld", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5163449", "l": "Eosinophils | Urine sediment | Urinalysis", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5180579", "l": "Segmented neutrophils | Synovial fluid | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0000033", "l": "apocrine cell", "d": ["An exocrine cell characterized by loss of part of the cytoplasm during the process of secretion. The secreted substance is accumulated at the apical end and is either budded off through the plasma membrane producing secreted vesicles or dissolved in the cytoplasm that is lost during secretion."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4246712", "l": "Vascular smooth muscle cell of right coronary artery", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0598091", "l": "stable cell line", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:1000283", "l": "smooth muscle fiber of transverse colon", "d": ["A smooth muscle cell that is part of the transverse colon."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002307", "l": "brush border cell of the proximal tubule", "d": ["A brush border epithelial cell located in the proximal tubule of the kidney that detects fluid flow."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157438", "l": "CD3+CD4+ (T4 helper) cells | Tissue and Smears | Cell markers", "d": []}]}
{"type": "biolink:Cell", "ic": "78.185623981295834", "identifiers": [{"i": "CL:0000177", "l": "testosterone secreting cell", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0000689", "l": "myoendocrine cell", "d": ["A cell with both myofibrils and secretory granules."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1267841", "l": "Lymphocyte positive for both CD4 antigen and 2H4 antigen", "d": []}, {"i": "SNOMEDCT:117528006", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0872268", "l": "self renewing cell", "d": []}]}
{"type": "biolink:Cell", "ic": "68.149273381153577", "identifiers": [{"i": "CL:0000469", "l": "ganglion mother cell", "d": ["A neural progenitor cell that is the daughter of a neuroblast (sensu arthopoda).  The progeny of ganglion mother cells develop into neurons, glia and (occasionally) epithelial cells."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0521183", "l": "Buhot cell", "d": []}, {"i": "SNOMEDCT:30469008", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:1000472", "l": "myoepithelial cell of tertiary lactiferous duct", "d": ["A myoepithelial cell that is part of the tertiary lactiferous duct."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:4030023", "l": "respiratory hillock cell", "d": ["A hillock cell that is located in respiratory epithelium. In some mammalian species, this cell type has been noted to express KRT13 and KRT4 and is postulated to play a role in squamous barrier function and immunomodulation."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C0596890", "l": "MCF-7 Cells", "d": []}, {"i": "NCIT:C18096", "l": "MCF7", "d": ["An adenocarcinoma cell line established in 1970 from the pleural effusion of a 69 year old Caucasian female patient with breast carcinoma."]}, {"i": "MESH:D061986", "l": "MCF-7 Cells", "d": []}]}
{"type": "biolink:Cell", "ic": "76.10017597303252", "identifiers": [{"i": "CL:0002490", "l": "organ of Corti supporting cell", "d": ["A supporting cell of the organ of Corti."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1183981", "l": "Chromaffin cell of right ovary", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2328882", "l": "Myocardial endocrine cell of interventricular septum", "d": []}]}
{"type": "biolink:Cell", "ic": "54.453542508307414", "identifiers": [{"i": "UMLS:C1519004", "l": "Peripheral (Post-Thymic) T-Lymphocyte", "d": []}, {"i": "NCIT:C38434", "l": "Peripheral (Post-Thymic) T-Lymphocyte", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4267789", "l": "Cells.CD27+IgD-", "d": []}]}
{"type": "biolink:Cell", "ic": "83.552982069901191", "identifiers": [{"i": "CL:0001033", "l": "hippocampal granule cell", "d": ["Granule cell with a soma found in the hippocampus."]}]}
{"type": "biolink:Cell", "ic": "72.370703631459492", "identifiers": [{"i": "CL:0000417", "l": "endopolyploid cell", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0000310", "l": "iron accumulating cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0005955", "l": "Bone Marrow Cells", "d": []}, {"i": "MESH:D001854", "l": "Bone Marrow Cells", "d": []}]}
{"type": "biolink:Cell", "ic": "75.58416670140862", "identifiers": [{"i": "UMLS:C1136335", "l": "Multipotent Stem Cells", "d": []}, {"i": "NCIT:C43419", "l": "Multipotent Stem Cell", "d": ["A cell that can only differentiate to a particular type of cells (e.g. hematopoietic cells or epithelial cells). --2005"]}, {"i": "MESH:D039902", "l": "Multipotent Stem Cells", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C3653065", "l": "stem cells from umbilical cord blood", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1182799", "l": "Epithelial cell of collecting duct of renal tubule", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1182710", "l": "Epithelial cell of stratum corneum of esophagus", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4239930", "l": "Primitive ectodermal cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4082186", "l": "Degenerating muscle fiber", "d": []}, {"i": "SNOMEDCT:85613007", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1440306", "l": "Cells.CD40", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2329893", "l": "Type N enteroendocrine cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5184397", "l": "Unidentified cells | Cerebral spinal fluid | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "ic": "52.739005612571937", "identifiers": [{"i": "CL:0000334", "l": "vegetative cell (sensu Fungi)", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:4023059", "l": "differentiation-committed oligodendrocyte precursor", "d": ["An oligodendrocyte precursor cell that is committed to differentiate."]}]}
{"type": "biolink:Cell", "ic": "49.16365107861899", "identifiers": [{"i": "CL:0000197", "l": "sensory receptor cell", "d": ["A cell that is capable of detection of a stimulus involved in sensory perception."]}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "CL:0000574", "l": "erythrophore", "d": ["A pigment cell derived from the neural crest. Contains pteridine and/or carotenoid pigments in structures called pterinosomes or erythrosomes. This gives an orange to red appearance."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0483189", "l": "CD3+DR+", "d": []}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "CL:4023031", "l": "L4 sst Martinotti interneuron (Mmus)", "d": ["A sst GABAergic cortical interneuron with a soma found in lower L2/3 and upper 5, L4 Sst cells have Martinotti morphology with ascending axons but denser local axons and sparser ‘fanning-out’ projections to L1. L4 sst cells have smaller membrane time constant to calb2 (L2/3/5 fan Martinotti Cell) and non-zero afterdepolarization (ADP)."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4323048", "l": "Oocyte in metaphase II arrest", "d": []}]}
{"type": "biolink:Cell", "ic": "75.751739371353352", "identifiers": [{"i": "CL:0000185", "l": "myoepithelial cell", "d": ["Contractile cells resembling smooth muscle cells that are present in glands, notably the mammary gland, and aid in secretion. This cell has long weaving dendritic processes containing myofilament."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C3639094", "l": "Adenovirus/Cytomegalovirus/Epstein-Barr Virus-specific Allogeneic Cytotoxic T Lymphocytes", "d": []}, {"i": "NCIT:C100102", "l": "Adenovirus/Cytomegalovirus/Epstein-Barr Virus-specific Allogeneic Cytotoxic T Lymphocytes", "d": ["Allogeneic tri-viral specific, adenovirus, cytomegalovirus and Epstein-Barr virus (Adv, CMV and EBV or ACE), cytotoxic T-lymphocytes (CTLs) with potential antiviral activity. Donor-derived T-cells were exposed to dendritic cells nucelofected with DNA plasmids encoding Hexon and Penton (Adv), pp65 and IE1 (CMV), and LMP2, EBNA1 and BZLF1 (EBV), all are critical proteins for the proliferation of these viruses, and subsequently maintained in the presence of interleukins 4 and 7 with a novel culture device to expand and sustain the repertoire of CTLs. After an allogeneic hematopoietic stem cell transplant (HSCT), infusion of these CTLs primed towards Adv, CMV and EBV may prevent viral infection by these pathogens."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5419508", "l": "Autologous Anti-PD-1 Antibody-activated Tumor-infiltrating Lymphocytes", "d": []}, {"i": "NCIT:C172191", "l": "Autologous Anti-PD-1 Antibody-activated Tumor-infiltrating Lymphocytes", "d": ["A preparation of autologous tumor infiltrating lymphocytes (TILs) activated by an anti-programmed cell death protein 1 (PD1) antibody, with potential immunomodulating activity. The autologous TILs are isolated from an autologous tumor sample and ex-vivo activated in the presence of anti-PD-1 antibody. Upon infusion of the autologous anti-PD1 antibody-activated TILs back into the patient, the cells specifically target and kill the patient's tumor cells."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5170918", "l": "Leukocytes | Blood cord | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "ic": "81.648881485605159", "identifiers": [{"i": "CL:0002028", "l": "basophil mast progenitor cell", "d": ["A cell type that can give rise to basophil and mast cells. This cell is CD34-positive, CD117-positive, CD125-positive, FceRIa-negative, and T1/ST2-negative, and expresses Gata-1, Gata-2, C/EBPa"]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5173472", "l": "Monocytes+Macrophages | Synovial fluid | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002124", "l": "CD27-positive gamma-delta T cell", "d": ["A circulating gamma-delta T cell that is CD27-positive and capable of producing IFN-gamma."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2329763", "l": "Transitional myocyte of atrioventricular bundle", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002239", "l": "ooblast", "d": ["A primordial cell from which an oocyte (ovum) ultimately is developed."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:1001096", "l": "kidney afferent arteriole endothelial cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5155170", "l": "Blasts | Peritoneal fluid | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "ic": "84.75972595860604", "identifiers": [{"i": "CL:0011004", "l": "lens fiber cell", "d": ["A vetebrate lens cell that is any of the elongated, tightly packed cells that make up the bulk of the mature lens in a camera-type eye."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002612", "l": "neuron of the ventral spinal cord", "d": ["A neuron of the ventral spinal cord."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5204705", "l": "Tasadenoturev-infected Allogeneic Bone Marrow-derived Mesenchymal Stem Cells", "d": []}, {"i": "NCIT:C159798", "l": "Tasadenoturev-infected Allogeneic Bone Marrow-derived Mesenchymal Stem Cells", "d": ["A preparation of bone marrow-derived allogeneic mesenchymal stem cells (MSCs) infected with tasadenoturev (Ad5-DNX-2401), an adenovirus serotype 5 strain that is selectively replication competent in cells defective in the Rb/p16 tumor suppressor pathway, with potential antineoplastic activity. Upon infusion of the tasadenoturev-infected bone marrow-derived MSCs, these cells target and deliver the adenovirus to tumor cells. The oncolytic virus then selectively transfects and replicates in the tumor cells, eventually leading to tumor cell lysis and the release of virus particles and various tumor associated antigens (TAAs). This may induce a systemic immune response against tumor cells expressing these TAAs and further infection and killing of nearby tumor cells by the released viral particles. Ad5-DNX-2401 contains an integrin binding RGD-4C motif, allowing Coxsackievirus and adenovirus receptor-independent infection of tumor cells, which are often deficient for Coxsackievirus and adenovirus receptors (CARs). As integral components of the late G1 restriction point, the Rb gene product and p16 are negative regulators of the cell cycle and are often defective in certain cancer types."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157300", "l": "CD135 blasts | Blood | Cell markers", "d": []}]}
{"type": "biolink:Cell", "ic": "83.552982069901191", "identifiers": [{"i": "UMLS:C1709170", "l": "Neoplastic Elongated Mononuclear Stromal Cell", "d": []}, {"i": "NCIT:C49054", "l": "Neoplastic Elongated Mononuclear Stromal Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C3640100", "l": "Lentivirus Vector rHIV7-shI-TAR-CCR5RZ-transduced Hematopoietic Progenitor Cells", "d": []}, {"i": "NCIT:C101371", "l": "Lentivirus Vector rHIV7-shI-TAR-CCR5RZ-transduced Hematopoietic Progenitor Cells", "d": ["Autologous, CD34-positive hematopoietic progenitor cells (HPCs) transduced with rHIV7-shI-TAR-CCR5RZ, a lentiviral vector encoding three anti-human immunodeficiency virus (HIV) RNA genes, with potential antineoplastic activity. The 3 RNA products produced by the lentilvirus are: a short hairpin RNA (shRNA) targeted to an exon of the HIV-1 genes tat/rev, designated as shI; a decoy for the HIV TAT reactive element, designated as TAR; a ribozyme targeting the host cells CCR5 chemokine receptor, designated as CCR5RZ. Upon administration, lentivirus vector rHIV7-shI-TAR-CCR5RZ-transduced hematopoietic progenitor cells expressing the 3 species of RNAs display 3 seperate mechanims of action: the shRNA blocks the transcription of tat/rev, the TAR decoy binds to the TAT protein that is essential for HIV replication, and CCR5RZ catalyzes CCR5 which is needed for viral attachment and entry into the host cells. Altogether, infusion of these HPCs may ultimately inhibit HIV replication and suppress HIV infection."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1179516", "l": "Epithelial cell of pancreas", "d": []}]}
{"type": "biolink:Cell", "ic": "66.367368887635308", "identifiers": [{"i": "UMLS:C1708886", "l": "Malignant Large Germ Cell with Abundant Cytoplasm", "d": []}, {"i": "NCIT:C54127", "l": "Malignant Large Germ Cell with Abundant Cytoplasm", "d": []}]}
{"type": "biolink:Cell", "ic": "83.023198044254755", "identifiers": [{"i": "CL:0002193", "l": "myelocyte", "d": ["A cell type that is the first of the maturation stages of the granulocytic leukocytes normally found in the bone marrow. Granules are seen in the cytoplasm. The nuclear material of the myelocyte is denser than that of the myeloblast but lacks a definable membrane. The cell is flat and contains increasing numbers of granules as maturation progresses."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5167385", "l": "Histiocytes | Bone marrow | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1441349", "l": "Abnormal blood cells.total", "d": []}]}
{"type": "biolink:Cell", "ic": "92.728541327098611", "identifiers": [{"i": "UMLS:C1512101", "l": "Dysplastic Erythroblast", "d": []}, {"i": "NCIT:C37056", "l": "Dysplastic Erythroblast", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1179580", "l": "Endothelial cell of sinusoid", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1182779", "l": "Acinar cell of sebaceous gland", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2350246", "l": "Monocyte-Macrophage Precursor Cells", "d": []}, {"i": "MESH:D055017", "l": "Monocyte-Macrophage Precursor Cells", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:1000346", "l": "enterocyte of epithelium proper of large intestine", "d": ["An enterocyte that is part of the epithelium proper of large intestine."]}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "UMLS:C1516398", "l": "Cerebriform-Like Lymphocyte", "d": []}, {"i": "NCIT:C39708", "l": "Cerebriform-Like Lymphocyte", "d": []}]}
{"type": "biolink:Cell", "ic": "90.82444074280258", "identifiers": [{"i": "CL:0000024", "l": "oogonial cell", "d": ["An undifferentiated germ cell that proliferates rapidly and gives rise to oocytes."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1522212", "l": "Endocrine Pancreas - Islet of Langerhans - Alpha Cell (MMHCC)", "d": []}, {"i": "NCIT:C22641", "l": "Mouse Alpha Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "71.51239634443381", "identifiers": [{"i": "CL:0000809", "l": "double-positive, alpha-beta thymocyte", "d": ["A thymocyte expressing the alpha-beta T cell receptor complex as well as both the CD4 and CD8 coreceptors."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1267917", "l": "Lymphocyte positive for CD40 antigen", "d": []}, {"i": "SNOMEDCT:117585007", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1440415", "l": "Cells.t(8;21)(q22;q22.3)(RUNX1T1,RUNX1)", "d": []}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "CL:0002347", "l": "CD27-high, CD11b-high natural killer cell, mouse", "d": ["A mature natural killer cell that is CD27-high and CD11b-high. This cell type is capable of interferon-gamma secretion."]}]}
{"type": "biolink:Cell", "ic": "83.023198044254755", "identifiers": [{"i": "CL:0000799", "l": "immature gamma-delta T cell", "d": ["A gamma-delta T cell that has an immature phenotype."]}]}
{"type": "biolink:Cell", "ic": "90.82444074280258", "identifiers": [{"i": "UMLS:C1519442", "l": "Specialized epithelial cell", "d": []}, {"i": "NCIT:C13006", "l": "Specialized Epithelial Cell", "d": ["A cell that covers the surface of the body and lines its cavities that has a specific function to perform."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4510924", "l": "Blast cell positive for CD21 antigen", "d": []}, {"i": "SNOMEDCT:725173000", "d": []}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "UMLS:C1514738", "l": "Reactive Glandular Cell", "d": []}, {"i": "NCIT:C36811", "l": "Reactive Glandular Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C4329680", "l": "Colony Forming Unit-Endothelial Cells", "d": []}, {"i": "NCIT:C129679", "l": "Colony Forming Unit-Endothelial Cells", "d": ["A population of adherent cells in fibronectin-coated culture that resemble endothelial cells."]}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "CL:2000053", "l": "splenic endothelial cell", "d": ["Any endothelial cell that is part of a spleen."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5171862", "l": "Macrocytes | Blood | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C3826992", "l": "Immature Myeloid Cell", "d": []}, {"i": "NCIT:C113503", "l": "Immature Myeloid Cell", "d": ["Hematopoietic cells that express the common myeloid marker CD33 but do not express the MHC class II molecule HLA-DR or other markers of mature myeloid or lymphoid cells. An accumulation of these cells may be associated with a decreased number of dendritic cells in the peripheral blood of patients with head and neck, lung or breast cancer."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1519562", "l": "Totipotent neuroepithelial stem cell", "d": []}, {"i": "NCIT:C33796", "l": "Totipotent Neuroepithelial Stem Cell", "d": ["A relatively undifferentiated cell that retains the ability to divide into any type of nerve cell."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2325209", "l": "Melanocyte of eyelid", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1267993", "l": "Lymphocyte positive for CD107A antigen", "d": []}, {"i": "SNOMEDCT:117433008", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1148320", "l": "Cells.CD11c-CD20+", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5177616", "l": "Platelets | Blood capillary | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5554913", "l": "Autologous BAFFR-targeting CAR T Cells", "d": []}, {"i": "NCIT:C178272", "l": "Autologous BAFFR-targeting CAR T Cells", "d": ["A preparation of autologous T-lymphocytes that are genetically engineered to express a chimeric antigen receptor (CAR) specific for the tumor-associated antigen (TAA) B-cell activating factor receptor (BAFFR; tumor necrosis factor receptor superfamily member 13C; TNFRSF13C; BLyS receptor 3; BR3), with potential immunostimulating and antineoplastic activities. Upon administration, the autologous BAFFR-targeting CAR T cells are directed to and induce selective toxicity in BAFFR-expressing tumor cells. BAFFR, a protein belonging to the TNF receptor superfamily, is expressed on the surface of certain types of cancer cells, including B-cell acute lymphoblastic leukemia. It plays a key role in the regulation of peripheral B-cell survival."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5163553", "l": "Epithelial cells.renal | Urine sediment | Urinalysis", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2339961", "l": "Nonkeratinized cell of stratum corneum of esophageal epithelium", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4696692", "l": "Cells.CD19+CD27+IgD-IgM-", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5179518", "l": "Reticulocytes | Fetus | Blood | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2350244", "l": "Megakaryocyte-Erythroid Progenitor Cells", "d": []}, {"i": "MESH:D055015", "l": "Megakaryocyte-Erythroid Progenitor Cells", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0945934", "l": "Cells.CD8+CD11b+", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1440328", "l": "Cells.CD5+CD8+", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0001057", "l": "myeloid dendritic cell, human", "d": ["A myeloid dendritic cell with the phenotype HLA-DRA-positive."]}]}
{"type": "biolink:Cell", "ic": "83.023198044254755", "identifiers": [{"i": "CL:0000011", "l": "migratory trunk neural crest cell", "d": ["Cell that is part of the migratory trunk neural crest population. Migratory trunk neural crest cells develop from premigratory trunk neural crest cells and have undergone epithelial to mesenchymal transition and delamination."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C3827113", "l": "Autologous Peripheral Blood Lymphocytes Cotransduced with Retroviral Vectors Encoding Inducible IL-12 and Anti-NY-ESO-1 TCR", "d": []}, {"i": "NCIT:C113161", "l": "Autologous Peripheral Blood Lymphocytes Cotransduced with Retroviral Vectors Encoding Inducible IL-12 and Anti-NY-ESO-1 TCR", "d": ["Human autologous peripheral blood lymphocytes (PBLs) transduced with two retroviral vectors, one encoding a T-cell receptor (TCR) specific for the cancer-testis antigen NY-ESO-1 and a second that encodes an inducible single chain form of interleukin-12 (IL-12) driven by a nuclear factor of activated T-cells (NFAT)-responsive promoter, with potential immunomodulating and antineoplastic activities. Following isolation of lymphocytes, retroviral vector transduction, and expansion of the cells ex vivo, the inducible IL-12/anti-NY-ESO-1 TCR-expressing autologous PBLs are re-administered into the patient by intravenous injection. As the transduced PBLs traverse the patient's circulation, they can bind to NY-ESO-1-overexpressing tumor cells. This binding activates the TCR signaling pathway in the transduced PBLs, which promotes NFAT-dependent gene transcription and induces expression of the cotransduced IL-12. IL-12 expression activates the immune system by promoting the secretion of interferon-gamma, activating natural killer cells (NKs), and inducing cytotoxic T-cell responses, which may result in both decreased cell proliferation and increased cell death for the NY-ESO-1-overexpressing tumor cells. NY-ESO-1, a tumor associated antigen (TAA), is found in normal testis and on the surface of various tumor cell types. NFAT, a family of transcription factors involved in immune responses, is activated by calcium signaling, which can occur downstream of TCR activation. Use of a retroviral vector to express an inducible IL-12 may remove the requirement for concomitant administration of interleukin-2 (IL-2) as is the case for conventional cell transfer immunotherapies."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4241340", "l": "Set of enteroendocrine cells of epithelium of stomach", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157441", "l": "CD3+CD4+CD27+CD62L+ cells | Blood | Cell markers", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0007020", "l": "bottle cell", "d": ["Characteristic early embryonic cell with a bottle or flask shape that is first to migrate inwards at the blastopore during gastrulation in amphibians."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5155101", "l": "Bizarre platelets | Blood | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "CL:0009095", "l": "endothelial cell of uterus", "d": ["An endothelial cell that is part of a uterus."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5556515", "l": "Allogeneic Multi-virus-specific T-cells ALVR106", "d": []}, {"i": "NCIT:C180636", "l": "Allogeneic Multi-virus-specific T-cells ALVR106", "d": ["A preparation of off-the-shelf (OTS), donor-derived T-lymphocytes that are specifically reactive towards four community acquired respiratory viruses: respiratory syncytial virus (RSV), influenza, parainfluenza virus (PIV), and human metapneumovirus (hMPV), with potential antiviral activity. Upon infusion into allogeneic hematopoietic stem cell transplant (HSCT), solid organ transplant (SOT) recipients or other immunocompromised patients, allogeneic multi-virus-specific T-cells ALVR106 provides virus-specific cellular immunity and causes specific anti-viral effects against the four viruses RSV, influenza, PIV and hMPV. This may prevent RSV, influenza, PIV and hMPV infection, and inhibits viral-associated diseases."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5148822", "l": "Reticulocytes.high fluorescence", "d": []}]}
{"type": "biolink:Cell", "ic": "80.511444690059548", "identifiers": [{"i": "UMLS:C1517540", "l": "Giant Astrocyte", "d": []}, {"i": "NCIT:C36842", "l": "Giant Astrocyte", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4050542", "l": "technetium Tc-99m red blood cells", "d": []}, {"i": "SNOMEDCT:89818005", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5420174", "l": "CD44v6-specific CAR T-cells", "d": []}, {"i": "NCIT:C173368", "l": "CD44v6-specific CAR T-cells", "d": ["A preparation of genetically modified T-lymphocytes transduced with a lentiviral vector encoding a fourth-generation specific chimeric antigen receptor (4SCAR) specific for CD44 variant domain 6 (CD44v6), with potential immunomodulating and antineoplastic activities. Upon administration, CD44v6-specific CAR T-cells specifically recognize and kill CD44v6-expressing tumor cells. CD44, a transmembrane glycoprotein and hyaluronic acid receptor, is expressed in healthy tissue and overexpressed in numerous cancer cell types. CD44v6, the isoform containing the variant domain 6 of CD44 gene, plays a key role in tumor cell invasion, proliferation and metastasis."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1267873", "l": "Lymphoblast positive for CD14 antigen", "d": []}, {"i": "SNOMEDCT:117552004", "d": []}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "CL:0000863", "l": "inflammatory macrophage", "d": ["An elicited macrophage that is recruited into the tissues in response to injury and infection as part of an inflammatory response, expresses high levels of pro-inflammatory cytokines, ROS and NO, and shows potent microbicidal activity."]}]}
{"type": "biolink:Cell", "ic": "83.552982069901191", "identifiers": [{"i": "UMLS:C1522703", "l": "Leukocyte - Lymphocyte (MMHCC)", "d": []}, {"i": "NCIT:C22572", "l": "Mouse Lymphocyte", "d": []}]}
{"type": "biolink:Cell", "ic": "75.26123597683771", "identifiers": [{"i": "UMLS:C1514009", "l": "Neoplastic Leydig Cell", "d": []}, {"i": "NCIT:C36896", "l": "Neoplastic Leydig Cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5159000", "l": "Chediak-Higashi cells | Blood | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C3176905", "l": "Cells.cytoplasmic CD22", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5221031", "l": "Neutrophils|Urine/Urine sed", "d": []}]}
{"type": "biolink:Cell", "ic": "79.849015605436421", "identifiers": [{"i": "CL:4023038", "l": "L6b glutamatergic cortical neuron", "d": ["A glutamatergic neuron with a soma found in cortical layer 6b. They are transcriptomically related to corticothalamic-projecting neurons but have differential projections to the thalamus or anterior cingulate."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C4725105", "l": "CD33-specific CAR Lentiviral Vector-transduced Autologous T-lymphocytes", "d": []}, {"i": "NCIT:C148530", "l": "CD33-specific CAR Lentiviral Vector-transduced Autologous T-lymphocytes", "d": ["Autologous T-lymphocytes transduced with a lentiviral vector expressing a chimeric antigen receptor (CAR) specific for the CD33 antigen, with potential immunomodulating and antineoplastic activities. Upon transfusion, CD33-specific CAR lentiviral vector-transduced autologous T-lymphocytes target and induce selective toxicity in CD33-expressing tumor cells. CD33 is expressed on normal non-pluripotent hematopoietic stem cells and on myeloid leukemia cells."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1511470", "l": "CY92", "d": []}, {"i": "NCIT:C20244", "l": "CY92", "d": ["Provider: CyThera, Inc., San Diego, CA. No information from provider. This cell line meets the criteria for the use of human embryonic stem cells by federally funded researchers."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5216278", "l": "Mononuclear cells|NCnc|Pt|Body fld", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2360310", "l": "Reticulocytes.high light scatter", "d": []}]}
{"type": "biolink:Cell", "ic": "58.394443759980035", "identifiers": [{"i": "UMLS:C0038250", "l": "Stem cells", "d": []}, {"i": "NCIT:C12662", "l": "Stem Cell", "d": ["An unspecialized cell that has the capacity for reproduction through cell division and can be induced to differentiate into a tissue or organ specific cell."]}, {"i": "MESH:D013234", "l": "Stem Cells", "d": []}, {"i": "SNOMEDCT:419758009", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0314587", "l": "Colony-forming unit of granulocytic lineage (cell)", "d": []}, {"i": "SNOMEDCT:445400007", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2327166", "l": "Type D enteroendocrine cell", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C0205868", "l": "Perineuronal satellite cell", "d": []}, {"i": "NCIT:C12619", "l": "Perineuronal Satellite Cell", "d": ["A flattened non-neuronal cell surrounding a ganglion cell."]}, {"i": "NCIT:C33516", "l": "Satellite Cell", "d": ["An elongated cell that is closely associated with a muscle fiber; it either is flattened against the fiber or occupies shallow depressions in its surface."]}, {"i": "MESH:D027161", "l": "Satellite Cells, Perineuronal", "d": []}, {"i": "SNOMEDCT:28922004", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4733097", "l": "PG13-CD19-H3 (anti-CD19 CAR) retroviral vector-transduced peripheral blood lymphocytes", "d": []}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "CL:0000571", "l": "leucophore", "d": ["A pigment cell derived from the neural crest. Contains uric acid or other purine crystals deposited in stacks called leucosomes. The crystals reflect light and this gives a white appearance under white light."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5420484", "l": "Autologous Anti-EGFR CAR-transduced CXCR 5-modified T-lymphocytes", "d": []}, {"i": "NCIT:C173958", "l": "Autologous Anti-EGFR CAR-transduced CXCR 5-modified T-lymphocytes", "d": ["A preparation of autologous, C-X-C chemokine receptor type 5 (CXCR 5)-modified T-lymphocytes that have been genetically modified to express a chimeric antigen receptor (CAR) targeting the epidermal growth factor receptor (EGFR), with potential immunostimulating and antineoplastic activities. Upon administration, the autologous anti-EGFR CAR-transduced CXCR 5-modified T-lymphocytes target and bind to EGFR-expressing tumor cells, thereby inducing selective toxicity in EGFR-expressing tumor cells. EGFR, overexpressed by a variety of cancer cell types, plays a key role in tumor cell proliferation, tumor angiogenesis and radio- and chemoresistance. CXCR5, and its ligand C-X-C motif chemokine 13 (CXCL13), are associated with a variety of tumors. CXCR5-CXCL13 interactions may be involved in the regulation of lymphocyte infiltration within the tumor microenvironment (TME)."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0009110", "l": "lymphatic endothelial cell of medulla ceiling", "d": ["A lymphatic endothelial cell located in the ceiling part of a lymph node medulla."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5168976", "l": "Immature basophils | Blood | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "ic": "54.39940096372387", "identifiers": [{"i": "UMLS:C1514049", "l": "Neoplastic Neuroepithelial Cell and Neoplastic Perineural Cell", "d": []}, {"i": "NCIT:C41408", "l": "Neoplastic Neuroepithelial Cell and Neoplastic Perineural Cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5186934", "l": "Platelets | Fetus | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "ic": "92.728541327098611", "identifiers": [{"i": "UMLS:C0872372", "l": "Totipotent Stem Cells", "d": []}, {"i": "NCIT:C12978", "l": "Totipotent Stem Cell", "d": ["Totipotent stem cells, such as the product of fertilization of an ovum and its progeny, are stem cells that have total potency to form an entire mature organism, e.g., a human being, although only if placed in a woman's uterus."]}, {"i": "MESH:D039901", "l": "Totipotent Stem Cells", "d": []}]}
{"type": "biolink:Cell", "ic": "36.969754466217545", "identifiers": [{"i": "UMLS:C0333717", "l": "Abnormal cell", "d": []}, {"i": "NCIT:C12913", "l": "Abnormal Cell", "d": ["An abnormal human cell type which can occur in either disease states or disease models."]}, {"i": "SNOMEDCT:39266006", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5418020", "l": "Autologous NKG2D CAR T-cells CYAD-02", "d": []}, {"i": "NCIT:C173710", "l": "Autologous NKG2D CAR T-cells CYAD-02", "d": ["A preparation of autologous T-lymphocytes that have been genetically modified and transduced with a retroviral vector to co-express a chimeric antigen receptor (CAR) encoding human natural-killer group 2, member D receptor protein (NKG2D or KLRK1) with a short hairpin RNA (shRNA) targeting MHC class I chain-related protein A (MICA) and MICB, with potential immunostimulating and antineoplastic activities. Upon infusion back into the patient, autologous NKG2D CAR T-cells CYAD-02 specifically recognize and bind to tumor cells expressing NKG2D ligands, resulting in the lysis of NKG2D ligand-expressing tumor cells. In addition, CYAD-02 targets, binds to and kills NKG2D ligand expressing tumor-associated endothelial cells in the neovasculature and immunosuppressive cells, such as regulatory T-cells (Tregs) and myeloid-derived suppressor cells (MDSCs) in the tumor microenvironment (TME) that express NKG2D ligands. It also activates macrophages within the TME. Ligands for NKG2D, such as MICA, MICB, and members of the UL16-binding proteins (ULBP)/retinoic acid early transcript 1 (RAET1) family, are overexpressed on infected cells and most cancer cell types, but are not expressed on most normal, healthy cells. NKG2D, a dimeric, type II transmembrane protein expressed on human natural killer (NK) and certain T-cells, in association with the natural adaptive protein DAP10, promotes the elimination of NKG2D ligand-expressing cells. The shRNA downregulates the expression of MICA and MICB on the CAR-T cells, which increases in-vitro cell expansion. This may enhance their persistence and increase anti-tumor activity."]}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "CL:0000371", "l": "protoplast", "d": ["The cell protoplasm after removal of the cell wall."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1517735", "l": "Centroblast", "d": []}, {"i": "NCIT:C32932", "l": "Centroblast", "d": ["An activated B-lymphocyte found in the germinal centers.  It has a large nucleus without clefts, finely dispersed chromatin, and a rim of basophilic cytoplasm."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C4725073", "l": "Autologous CD5-specific CAR-28 zeta CAR T-cells", "d": []}, {"i": "NCIT:C148490", "l": "Autologous CD5-specific CAR-28 zeta CAR T-cells", "d": ["Autologous T-lymphocytes transduced with a retroviral vector expressing a chimeric antigen receptor (CAR) consisting of an anti-CD5 single chain variable fragment (scFv) coupled to the costimulatory signaling domain CD28 and the zeta chain of the T-cell receptor (TCR), with potential immunomodulating and antineoplastic activities. Upon transfusion, the autologous CD5-specific CAR-28 zeta CAR T-cells are directed to and induce selective toxicity in CD5-expressing tumor cells. The tumor-associated antigen (TAA) CD5 is a T-cell surface glycoprotein expressed on the surface of normal T-cells, and is overexpressed on various B- and T-cell malignancies; its expression is associated with poor prognosis."]}]}
{"type": "biolink:Cell", "ic": "66.70470389845471", "identifiers": [{"i": "CL:0000311", "l": "keratin accumulating cell", "d": []}]}
{"type": "biolink:Cell", "ic": "84.128890093485552", "identifiers": [{"i": "CL:0002005", "l": "CD34-positive, CD38-positive megakaryocyte erythroid progenitor cell", "d": ["A megakaryocyte erythroid progenitor cell is CD34-positive, CD38-positive and is IL3-receptor alpha-negative and CD45RA-negative."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0682538", "l": "intact cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2332530", "l": "Goblet cell of epithelium proper of ileum", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0545061", "l": "May-Hegglin cell", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:1000486", "l": "basal cell of urothelium", "d": ["A basal cell that is part of the urothelium. Compared to other urothelial cell types, a basal cell of the urothelium is positioned along the basement membrane, is the most undifferentiated and serves a progenitor role."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1511467", "l": "CY81", "d": []}, {"i": "NCIT:C20241", "l": "CY81", "d": ["Provider: CyThera, Inc., San Diego, CA. No information from provider. This cell line meets the criteria for the use of human embryonic stem cells by federally funded researchers."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C2346935", "l": "Malignant Giant Osteoblast", "d": []}, {"i": "NCIT:C67524", "l": "Malignant Giant Osteoblast", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5172552", "l": "Metamyelocytes/100 cells | Bone marrow | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "ic": "74.516770421031836", "identifiers": [{"i": "UMLS:C1514028", "l": "Neoplastic Monocytoid B-Lymphocyte", "d": []}, {"i": "NCIT:C37003", "l": "Neoplastic Monocytoid B-Lymphocyte", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1440355", "l": "CD79a+ cell", "d": []}, {"i": "SNOMEDCT:732274004", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5196052", "l": "Human Cord Blood Hematopoietic Progenitor Cell 900000000 in 25 mL INTRAVENOUS SOLUTION [HEMATOPOIETIC PROGENITOR CELLS, CORD BLOOD]", "d": []}]}
{"type": "biolink:Cell", "ic": "85.457082654197222", "identifiers": [{"i": "CL:0002316", "l": "supporting cell of vestibular epithelium", "d": ["A supporting cell of the vestibular epithelium."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157287", "l": "CD126 blasts | Bone marrow | Cell markers", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1267896", "l": "Lymphocyte positive for CD24 antigen", "d": []}, {"i": "SNOMEDCT:117569002", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1267983", "l": "Lymphocyte positive for CD96 antigen", "d": []}, {"i": "SNOMEDCT:117423000", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:4023061", "l": "hippocampal CA4 neuron", "d": ["A neuron that has its soma located in CA4 of the hippocampus."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002403", "l": "mature Vgamma2-positive fetal thymocyte", "d": ["A thymocyte that has a T cell receptor consisting of a gamma chain containing Vgamma2 segment, and a delta chain. This cell type is CD4-negative, CD8-negative and CD24-negative. This cell-type is found in the fetal thymus."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4266557", "l": "Hematopoietic progenitor cells^BPU", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1267961", "l": "Lymphocyte positive for CD66D antigen", "d": []}, {"i": "SNOMEDCT:117402006", "d": []}]}
{"type": "biolink:Cell", "ic": "60.562575753191759", "identifiers": [{"i": "CL:0000232", "l": "erythrocyte", "d": ["A red blood cell. In mammals, mature erythrocytes are biconcave disks containing hemoglobin whose function is to transport oxygen."]}]}
{"type": "biolink:Cell", "ic": "87.120474278337809", "identifiers": [{"i": "CL:0002499", "l": "spongiotrophoblast cell", "d": ["A trophoblast cell that arises in the junctional zone (basal plate) of the placenta."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0004233", "l": "DAPI-3 amacrine cell", "d": ["An amacrine cell with a medium dendritic field and post-synaptic terminals that stratify at S2, with a second stratification that occurs in S3 and S4. This cell type releases the neurotransmitter glycine."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1317185", "l": "Cells.CD10+CD20+", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2362797", "l": "Blood cell precursor - general anatomical term", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C2348928", "l": "HLA-Matched Donor Mononuclear Cell-Enriched Leukocytes Apocell", "d": []}, {"i": "NCIT:C71162", "l": "HLA-Matched Donor Mononuclear Cell-Enriched Leukocytes Apocell", "d": ["A preparation of allogeneic HLA-matched leukocytes treated with a derivative of placental protein 14 (PP14) with potential immunomodulating activity. PP14 derivative-treated HLA-matched donor mononuclear cell-enriched leukocytes contain at least fifty-five percent early-apoptotic T cells; after infusion and when processed by recipient dendritic cells, early-apoptotic T cells may help induce a decrease in the donor effector T-cell responses against the recipient of an allogeneic hematopoietic stem cell (HSC) transplant, thereby minimizing allogeneic HSC transplant-related graft-versus-host disease (GVHD). PP14, a 162 amino acid glycosylated protein secreted by the late secretory phase endometrium, binds to T cells in a carbohydrate fashion and has been shown to induce T-cell apoptosis; maternal immune tolerance to the fetus and pregnancy-related remissions of autoimmune disease may involve PP14-induced T cell apoptosis."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1517057", "l": "Extraglomerular Mesangial Cells", "d": []}, {"i": "NCIT:C32572", "l": "Extraglomerular Mesangial Cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157396", "l": "CD22 cells | Blood | Cell markers", "d": []}]}
{"type": "biolink:Cell", "ic": "71.335885432862128", "identifiers": [{"i": "UMLS:C1514006", "l": "Neoplastic Centroblast", "d": []}, {"i": "NCIT:C37014", "l": "Neoplastic Centroblast", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4740190", "l": "100 Cells.235a", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157290", "l": "CD127 blasts | Bone marrow | Cell markers", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5666853", "l": "Allogeneic iC9/CD19-CAR-CD28-zeta-2A-IL15-transduced Cord Blood-derived Natural Killer Cells TAK-007", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2952434", "l": "Interdigitating dendritic cell of splenic white pulp", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0000973", "l": "IgA memory B cell", "d": ["A class switched memory B cell that expresses IgA."]}]}
{"type": "biolink:Cell", "ic": "45.250857119211346", "identifiers": [{"i": "CL:0000099", "l": "interneuron", "d": ["Most generally any neuron which is not motor or sensory. Interneurons may also refer to neurons whose axons remain within a particular brain region as contrasted with projection neurons which have axons projecting to other brain regions."]}]}
{"type": "biolink:Cell", "ic": "73.124874125835319", "identifiers": [{"i": "UMLS:C1518629", "l": "Osteoclast-Like Giant Cell", "d": []}, {"i": "NCIT:C36827", "l": "Osteoclast-Like Giant Cell", "d": ["A large, multinucleated cell that expresses osteoclast-specific markers."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1979078", "l": "Blasts.CD117", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5178306", "l": "Promyelocytes | Blood | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1518218", "l": "Malignant Neuroendocrine Cell with Moderate Cytoplasm", "d": []}, {"i": "NCIT:C36916", "l": "Malignant Neuroendocrine Cell with Moderate Cytoplasm", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2332040", "l": "Goblet cell of epithelium of principal gastric gland", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1959571", "l": "Suppressor T-Lymphocytes, Naturally-Occurring", "d": []}]}
{"type": "biolink:Cell", "ic": "76.46797986554256", "identifiers": [{"i": "UMLS:C0229579", "l": "Structure of thyroid parafollicular cell", "d": []}, {"i": "NCIT:C33261", "l": "C-Cell", "d": ["A neuroendocrine cell found in the thyroid gland interspersed among the follicular cells or in clusters between the follicles. It produces and secretes calcitonin in response to its calcium receptor."]}, {"i": "SNOMEDCT:50552001", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1440368", "l": "Cells.CD91", "d": []}]}
{"type": "biolink:Cell", "ic": "92.728541327098611", "identifiers": [{"i": "CL:0008018", "l": "somatic muscle myoblast", "d": ["A myoblast that is commited to developing into a somatic muscle."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157370", "l": "CD2 cells | Bone marrow | Cell markers", "d": []}]}
{"type": "biolink:Cell", "ic": "92.728541327098611", "identifiers": [{"i": "CL:1000547", "l": "kidney inner medulla collecting duct epithelial cell", "d": ["An epithelial cell that is part of some inner medullary collecting duct."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1266875", "l": "Epidermal Langerhans cell", "d": []}, {"i": "SNOMEDCT:127854005", "d": []}]}
{"type": "biolink:Cell", "ic": "82.076046914303362", "identifiers": [{"i": "CL:0001063", "l": "neoplastic cell", "d": ["An abnormal cell exhibiting dysregulation of cell proliferation or programmed cell death and capable of forming a neoplasm, an aggregate of cells in the form of a tumor mass or an excess number of abnormal cells (liquid tumor) within an organism."]}]}
{"type": "biolink:Cell", "ic": "56.307996466303948", "identifiers": [{"i": "CL:0008002", "l": "skeletal muscle fiber", "d": ["A transversely striated, synctial cell of skeletal muscle. It is formed when proliferating myoblasts exit the cell cycle, differentiate and fuse."]}]}
{"type": "biolink:Cell", "ic": "77.712653754434029", "identifiers": [{"i": "UMLS:C1709193", "l": "Neoplastic Perivascular Epithelioid Cell", "d": []}, {"i": "NCIT:C53681", "l": "Neoplastic Perivascular Epithelioid Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5419828", "l": "SARS-CoV-2 Antigen-specific Cytotoxic T-lymphocytes", "d": []}, {"i": "NCIT:C172750", "l": "SARS-CoV-2 Antigen-specific Cytotoxic T-lymphocytes", "d": ["A population of cytotoxic T-lymphocytes (CTLs) that are specifically reactive to SARS-CoV-2, with potential antiviral activity. Upon administration of the SARS-CoV-2 antigen-specific CTLs, these CTLs target and lyse the SARS-CoV-2-infected cells."]}]}
{"type": "biolink:Cell", "ic": "81.247621244257502", "identifiers": [{"i": "CL:1000488", "l": "cholangiocyte", "d": ["An epithelial cell that is part of the bile duct. Cholangiocytes contribute to bile secretion via net release of bicarbonate and water. They are cuboidal epithelium in the small interlobular bile ducts, but become columnar and mucus secreting in larger bile ducts approaching the porta hepatis and the extrahepatic ducts."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0000742", "l": "periarticular chondrocyte", "d": ["A round chondrocyte that first differentiates in the late embryonic growth plate of bone."]}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "UMLS:C1708865", "l": "Malignant Chondrocyte with Clear Cytoplasm", "d": []}, {"i": "NCIT:C53492", "l": "Malignant Chondrocyte with Clear Cytoplasm", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1182612", "l": "Epithelial cell of lacrimal canaliculus", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2950978", "l": "Endothelial cell of endocardium for atrium", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0597694", "l": "Xenopus oocyte", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1721028", "l": "Blastocyst Inner Cell Mass", "d": []}, {"i": "MESH:D053624", "l": "Blastocyst Inner Cell Mass", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002318", "l": "peripheral blood mesothelial cell", "d": ["A mesothelial cell capable of circulating in the blood by first losing its squamous character. This cell can incorporate into the regenerating mesothelium."]}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "CL:0017010", "l": "hillock cell of urethral epithelium", "d": ["A hillock cell that is part of the urethra."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5380999", "l": "Cells.CD8.HLA-B35 CMV specific", "d": []}]}
{"type": "biolink:Cell", "ic": "83.023198044254755", "identifiers": [{"i": "CL:4030034", "l": "respiratory ciliated cell", "d": ["A ciliated cell of the respiratory system. Ciliated cells are present in airway epithelium."]}]}
{"type": "biolink:Cell", "ic": "87.120474278337809", "identifiers": [{"i": "UMLS:C1708900", "l": "Malignant Parathyroid Gland Clear Cell", "d": []}, {"i": "NCIT:C48270", "l": "Malignant Parathyroid Gland Clear Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "92.728541327098611", "identifiers": [{"i": "CL:4023189", "l": "parasol ganglion cell of retina", "d": ["A retinal ganglion cell located in the ganglion cell layer of the retina. This cell projects to magnocellular cells in the lateral geniculate nucleus (LGN). They have large cell bodies and extensive, branching dendritic networks that contribute to their large receptive fields."]}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "CL:1000384", "l": "type 2 vestibular sensory cell of epithelium of macula of saccule of membranous labyrinth", "d": ["A type II vestibular sensory cell that is part of the epithelium of macula of saccule of membranous labyrinth."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5426725", "l": "100 cells.CD45", "d": []}]}
{"type": "biolink:Cell", "ic": "69.58597274768276", "identifiers": [{"i": "UMLS:C1514025", "l": "Neoplastic Mesothelial Cell", "d": []}, {"i": "NCIT:C41605", "l": "Neoplastic Mesothelial Cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4253022", "l": "Set of cells of pancreatic islet", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0920441", "l": "circulating cancer cell", "d": []}]}
{"type": "biolink:Cell", "ic": "73.976162571356099", "identifiers": [{"i": "UMLS:C1708876", "l": "Malignant Fibroblast", "d": []}, {"i": "NCIT:C49028", "l": "Malignant Fibroblast", "d": []}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "CL:0002471", "l": "MHC-II-negative non-classical monocyte", "d": ["Gr1-low non-classical monocyte that lacks expression of a MHC-II complex."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1182792", "l": "Epithelial cell of proximal tubule", "d": []}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "CL:0005005", "l": "cyanoblast", "d": ["A non-terminally differentiated cell that originates from the neural crest and differentiates into a cyanophore."]}]}
{"type": "biolink:Cell", "ic": "92.728541327098611", "identifiers": [{"i": "CL:4033037", "l": "mucus secreting cell of tracheobronchial tree submucosal gland", "d": ["A mucus secreting cell of a submucosal gland of the tracheobronchial tree."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1440274", "l": "CD25+ CD19+ cells", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1179470", "l": "Epithelial cell of stomach", "d": []}]}
{"type": "biolink:Cell", "ic": "84.75972595860604", "identifiers": [{"i": "CL:0002231", "l": "epithelial cell of prostate", "d": ["An epithelial cell of the prostate."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1181530", "l": "Type I cell of adrenal medulla", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1440051", "l": "Abnormal blood cells.CD19", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "NCIT:C32734", "l": "Hepatic Stellate Cell", "d": ["A star-shaped cell in the liver associated with the development of fibrosis. When stellate cells are activated in response to an injury, they proliferate and synthesize large amounts of extracellular matrix which results in deposition of scar or fibrous tissue."]}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "CL:0005004", "l": "pigment erythroblast", "d": ["A non-terminally differentiated cell that originates from the neural crest and differentiates into an erythrophore."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5161803", "l": "Cytoplasmic CD3 blasts | XXX | Cell markers", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157371", "l": "CD2 cells | Cerebral spinal fluid | Cell markers", "d": []}]}
{"type": "biolink:Cell", "ic": "73.011730055819953", "identifiers": [{"i": "UMLS:C1510723", "l": "Abnormal Erythroid Precursor", "d": []}, {"i": "NCIT:C37053", "l": "Abnormal Erythroid Precursor", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5545271", "l": "Tissue Resident Memory T Cells", "d": []}]}
{"type": "biolink:Cell", "ic": "84.128890093485552", "identifiers": [{"i": "CL:1000405", "l": "epithelial cell of appendix", "d": ["An epithelial cell that is part of the appendix."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5572419", "l": "Acanthocytes | Urine sediment | Urinalysis", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1317625", "l": "Plasma cell precursor", "d": []}]}
{"type": "biolink:Cell", "ic": "77.061101857006449", "identifiers": [{"i": "UMLS:C1514026", "l": "Neoplastic Monoblast", "d": []}, {"i": "NCIT:C37181", "l": "Neoplastic Monoblast", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2930253", "l": "Carticel", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:2000052", "l": "umbilical artery endothelial cell", "d": ["Any endothelial cell of artery that is part of a umbilical cord."]}]}
{"type": "biolink:Cell", "ic": "73.976162571356099", "identifiers": [{"i": "UMLS:C1519000", "l": "Peripheral Epidermotropic T-Lymphocyte", "d": []}, {"i": "NCIT:C38323", "l": "Peripheral Epidermotropic T-Lymphocyte", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:1001097", "l": "kidney afferent arteriole smooth muscle cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C3494246", "l": "Sf21 Cells", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:4030047", "l": "matrix D2 medium spiny neuron", "d": ["A DRD2-expressing medium spiny neuron that is part of a matrix compartment of dorsal striatum."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0000406", "l": "CNS short range interneuron", "d": []}]}
{"type": "biolink:Cell", "ic": "92.728541327098611", "identifiers": [{"i": "CL:0000658", "l": "cuticle secreting cell", "d": ["An epithelial cell that secretes cuticle."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5575457", "l": "Autologous Anti-CD7-CAR-CD28zeta T-cells", "d": []}, {"i": "NCIT:C185169", "l": "Autologous Anti-CD7-CAR-CD28zeta T-cells", "d": ["A preparation of autologous T-lymphocytes that have been genetically engineered to express a chimeric antigen receptor (CAR) directed against the CD7 antigen and linked to the co-stimulatory domains of CD28 and the zeta chain of the TCR/CD3 complex (CD3-zeta) (CD28zeta), with potential immunostimulating and antineoplastic activities. Upon administration, the autologous anti-CD7-CAR-CD28zeta T-cells specifically recognize and bind to CD7-expressing tumor cells, resulting in specific T-cell-mediated tumor cell lysis. CD7 is a transmembrane glycoprotein expressed by T-cells and natural killer (NK) cells and their precursors. It is expressed in the majority of lymphoblastic T-cell leukemias and lymphomas and in a subset of peripheral T-cell lymphomas."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2324544", "l": "Type I enteric ganglion neuron", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5154002", "l": "B lymphocytes | Blood | Cell markers", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0598828", "l": "granule cell (connective tissue)", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002593", "l": "smooth muscle cell of the internal thoracic artery", "d": ["A smooth muscle of the internal thoracic artery."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5171660", "l": "Lymphocytes | Cerebral spinal fluid | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0333723", "l": "Folded cell", "d": []}, {"i": "SNOMEDCT:39922000", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0009036", "l": "appendix macrophage", "d": ["A macrophage located in the vermiform appendix."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002463", "l": "SIRPa-positive adipose dendritic cell", "d": ["An adipose dendritic cell that is SIRPa-positive."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:2000054", "l": "hepatic pit cell", "d": ["A large, granular, liver specific natural killer cell that adheres to the endothelial cells of the hepatic sinusoid."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4322678", "l": "Chromosome pair", "d": []}]}
{"type": "biolink:Cell", "ic": "48.888328131961593", "identifiers": [{"i": "CL:0000526", "l": "afferent neuron", "d": ["A neuron which conveys sensory information centrally from the periphery."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1440283", "l": "Cells.CD3+CD4+CD45RO-CD45RA-", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1277066", "l": "Entire Sertoli cell", "d": []}, {"i": "SNOMEDCT:367716000", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C2983758", "l": "NY-ESO-1 Reactive TCR Retroviral Vector Transduced Autologous PBL", "d": []}, {"i": "NCIT:C90559", "l": "NY-ESO-1 Reactive TCR Retroviral Vector Transduced Autologous PBL", "d": ["Human autologous peripheral blood lymphocytes (PBLs) transduced with a retroviral vector encoding a T cell receptor (TCR) specific for the cancer-testis antigen NY-ESO-1, with potential antineoplastic activity. Upon isolation, transduction, expansion ex vivo, and reintroduction into the patient, the NY-ESO-1 reactive TCR-transduced autologous PBLs bind to NY-ESO-1-overexpressing tumor cells. This may result in a specific cytotoxic T-lymphocyte (CTL) killing of NY-ESO-1-positive cancer cells. NY-ESO-1, a tumor associated antigen (TAA), is found in normal testis and on the surface of various tumor cell types; the TCR is specific for NY-ESO-1:157-165."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0483184", "l": "CD16+CD57+", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5216190", "l": "Basophils|NCnc|Pt|Bld", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0682539", "l": "cuboid cell", "d": []}]}
{"type": "biolink:Cell", "ic": "74.659114980698789", "identifiers": [{"i": "UMLS:C0333727", "l": "Signet ring cell", "d": []}, {"i": "NCIT:C12487", "l": "Signet Ring Cell", "d": ["A neoplastic cell containing cytoplasmic mucin. The presence of mucin pushes the nucleus of the cell to the periphery, assuming a configuration resembling a signet ring."]}, {"i": "SNOMEDCT:86918008", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5571708", "l": "Erythrocytes.non-dysmorphic|Urine/Urine sed", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0007007", "l": "notochordal sheath cell", "d": ["Notochordal cell that is part of the outer epithelium of the notochord and surrounds the vacuolated notochord cells."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C3496268", "l": "B5 serotonin cells", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0301863", "l": "\"U\" lymphocyte", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C3828708", "l": "Oncolytic Adenovirus ICOVIR5-infected Autologous Mesenchymal Stem Cells", "d": []}, {"i": "NCIT:C107160", "l": "Oncolytic Adenovirus ICOVIR5-infected Autologous Mesenchymal Stem Cells", "d": ["Bone marrow-derived autologous mesenchymal stem cells (MSCs) infected with the oncolytic, replication-competent adenovirus ICOVIR5, with potential antineoplastic activity. Upon infusion of the oncolytic adenovirus ICOVIR5-infected autologous MSCs, these cells target the adenovirus to tumors. The oncolytic virus then selectively transfects and replicates in the tumor cells causing a direct cytotoxic effect and lysis of the tumor cells. In addition, the viral infection may stimulate an immune response against the virally-infected tumor cells. This may lead to an inhibition of cancer cell proliferation. ICOVIR-5, a virus derived from wild-type human adenovirus serotype 5 (Had5), has been modified to selectively replicate in tumor cells that have a deregulated retinoblastoma/E2F pathway."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1522252", "l": "Ovary - Granulosa Cell (MMHCC)", "d": []}, {"i": "NCIT:C22662", "l": "Mouse Granulosa Cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1267972", "l": "Lymphocyte positive for CD80 antigen", "d": []}, {"i": "SNOMEDCT:117412004", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1640380", "l": "Bone Marrow Stromal Cells", "d": []}]}
{"type": "biolink:Cell", "ic": "88.140761698499901", "identifiers": [{"i": "CL:0000052", "l": "totipotent stem cell", "d": ["A stem cell from which all cells of the body can form."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1267914", "l": "Lymphocyte positive for CD37 antigen", "d": []}, {"i": "SNOMEDCT:117583000", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1440373", "l": "Cells.CD97", "d": []}]}
{"type": "biolink:Cell", "ic": "80.17194633000733", "identifiers": [{"i": "CL:1001319", "l": "bladder cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0229642", "l": "Eosinophilic myelocyte", "d": []}, {"i": "SNOMEDCT:90961003", "d": []}]}
{"type": "biolink:Cell", "ic": "84.75972595860604", "identifiers": [{"i": "CL:0002559", "l": "hair follicle cell", "d": ["An animal cell that is part of a hair follicle."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1181541", "l": "Type I cell of paraganglion", "d": []}]}
{"type": "biolink:Cell", "ic": "73.721563224321088", "identifiers": [{"i": "UMLS:C1510735", "l": "Abnormal Syncytiotrophoblastic Cell", "d": []}, {"i": "NCIT:C36800", "l": "Abnormal Syncytiotrophoblastic Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C0003154", "l": "Anterior Horn Cells", "d": []}, {"i": "NCIT:C12645", "l": "Anterior Horn Cell", "d": ["A motor neuron that is located in one of the ventral horns of the spinal cord and innervates skeletal muscles of the trunk or head."]}, {"i": "MESH:D000870", "l": "Anterior Horn Cells", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1507170", "l": "Cells.CD3+CD62L+", "d": []}]}
{"type": "biolink:Cell", "ic": "87.120474278337809", "identifiers": [{"i": "CL:1001431", "l": "kidney collecting duct principal cell", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002579", "l": "omentum preadipocyte", "d": []}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "CL:0000456", "l": "mineralocorticoid secreting cell", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1879553", "l": "Adenocarcinoma Cell with Abundant Finely Vacuolated Cytoplasm", "d": []}, {"i": "NCIT:C54718", "l": "Adenocarcinoma Cell with Abundant Finely Vacuolated Cytoplasm", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1510967", "l": "Atypical Transitional Cell", "d": []}, {"i": "NCIT:C36911", "l": "Atypical Transitional Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5556490", "l": "Autologous Anti-HER2 CAR-T Cells", "d": []}, {"i": "NCIT:C180598", "l": "Autologous Anti-HER2 CAR-T Cells", "d": ["A preparation of autologous T-lymphocytes that have been genetically modified to express a chimeric antigen receptor (CAR) targeting the tumor-associated antigen (TAA) human epidermal growth factor 2 (HER2; ErbB2; HER-2), with potential immunostimulating and antineoplastic activities. Upon administration, autologous anti-HER2 CAR-T cells target and bind to HER2-expressing tumor cells, thereby inducing selective toxicity in HER2-expressing tumor cells. HER2 is overexpressed in a variety of cancer cell types and is associated with increased tumor cell proliferation."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002450", "l": "tether cell", "d": ["A specialized hair cell that has an elongated kinocilium upon which an otolith accretes. The tether cell then anchors the otolith in place."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2330872", "l": "Brush cell of epithelium of bronchus", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1518114", "l": "MB02", "d": []}, {"i": "NCIT:C20276", "l": "MB02", "d": ["Provider: Maria Biotech Co. Ltd. - Maria Infertility Hospital Medical Institute, Seoul, Korea. Information from provider and not independently verified by NIH: Cells are positive for cell markers SSEA-3, SSEA-4, Oct-4, alkaline phosphatase activity and telomerase activity; Cells are negative for the cell marker SSEA-1; Cell has normal karyotype (46 XX); Differentiation in vitro into neuron; Cells were cultured in feeder-free culture condition using Matrigel coated plate. This cell line meets the criteria for the use of human embryonic stem cells by federally funded researchers."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1267968", "l": "Lymphocyte positive for CD74 antigen", "d": []}, {"i": "SNOMEDCT:117408005", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5216274", "l": "Monocytes|NCnc|Pt|CSF", "d": []}]}
{"type": "biolink:Cell", "ic": "84.128890093485552", "identifiers": [{"i": "UMLS:C1711303", "l": "Malignant Sebocyte", "d": []}, {"i": "NCIT:C43339", "l": "Malignant Sebocyte", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5221144", "l": "Mesothelial cells|NCnc|Pt|Periton fld", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4322818", "l": "CD99+ T lymphocyte", "d": []}]}
{"type": "biolink:Cell", "ic": "72.370703631459492", "identifiers": [{"i": "UMLS:C1516089", "l": "Atypical Adipocyte", "d": []}, {"i": "NCIT:C36977", "l": "Atypical Adipocyte", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5206705", "l": "Autologous LMP1/LMP2/EBNA1-specific HLA-A02:01/24:02/11:01-restricted TCR-expressing T-lymphocytes YT-E001", "d": []}, {"i": "NCIT:C162627", "l": "Autologous LMP1/LMP2/EBNA1-specific HLA-A02:01/24:02/11:01-restricted TCR-expressing T-lymphocytes YT-E001", "d": ["A preparation of autologous T-lymphocytes that have been transduced with a lentiviral vector encoding a T-cell receptor (TCR) specific for human leukocyte antigen (HLA)-A02:01/24:02/11:01-restricted Epstein-Barr virus (EBV) latent membrane proteins (LMP) 1 and 2, and EBV nuclear antigen 1 (EBNA1), with potential antineoplastic activity. Upon administration, the autologous LMP1/LMP2/EBNA1-specific, HLA-A02:01/24:02/11:01-restricted TCR-expressing T-lymphocytes YT-E001 recognize and bind to HLA-presented EBV peptides, which may promote cell death and inhibit the growth of tumor cells expressing LMP1, LMP2 or EBNA1. LMP1, LMP2, and EBNA1 are expressed in various, EBV-associated malignancies, including nasopharyngeal cancer and EBV-positive Hodgkin lymphoma."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5555556", "l": "Allogeneic CRISPR-edited Anti-CD19 CAR-T Cells CB-010", "d": []}, {"i": "NCIT:C179255", "l": "Allogeneic CRISPR-edited Anti-CD19 CAR-T Cells CB-010", "d": ["A preparation of allogeneic, off-the-shelf T-lymphocytes genetically modified to express a chimeric antigen receptor (CAR) specific for the tumor-associated antigen (TAA) CD19, and clustered regularly interspaced short palindromic repeats (CRISPR)-edited to eliminate endogenous T-cell receptor (TCR) and programmed death 1 (PD-1; PDCD1; CD279; programmed cell death-1) expression, with potential immunostimulating and antineoplastic activities. Upon administration, the allogeneic CRISPR-edited anti-CD19 CAR-T cells CB-010 recognize and bind to CD19-expressing tumor cells. This may result in a specific cytotoxic T-lymphocyte (CTL)-mediated killing of CD19-positive tumor cells. PD-1, an immune checkpoint receptor expressed on T-cells, plays a key role in tumor immune evasion by binding to its ligand programmed death ligand 1 (PD-L1; cluster of differentiation 274; CD274; programmed cell death-1 ligand 1) expressed on tumor cells. By removing PD-1 from T-cells, PD-1-mediated signaling is halted which may decrease T-cell exhaustion and may enhance T-cell activity against the CD19-expressing tumor cells. The endogenous TCR is removed to prevent graft-versus-host disease (GvHD). CD19 antigen is a B-cell specific cell surface antigen overexpressed in B-cell lineage malignancies."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C4055480", "l": "Allogeneic BK-specific Cytotoxic T-lymphocytes", "d": []}, {"i": "NCIT:C123277", "l": "Allogeneic BK-specific Cytotoxic T-lymphocytes", "d": ["Allogeneic cytotoxic T-lymphocytes (CTLs) that are specifically reactive to BK virus (BKV), with potential antiviral activity. Upon infusion of allogeneic BK-specific CTLs into immunocompromised patients who were infected with BKV after allogeneic stem cell transplantation, these cells exert a specific CTL response against BKV, thereby killing and eliminating the BKV-infected cells. BKV is a member of the polyomavirus family that may cause mild symptoms in normal, healthy people; however, BKV infection can lead to severe disease in immunocompromised patients."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5173493", "l": "Mononuclear cells | Body fluid | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5417969", "l": "AIC100", "d": []}, {"i": "NCIT:C173378", "l": "Autologous Anti-ICAM-1-CAR-CD28-4-1BB-CD3zeta-expressing T-cells AIC100", "d": ["A preparation of autologous T-lymphocytes that have been transduced with a lentiviral vector to express a chimeric antigen receptor (CAR) containing the Inserted (I) domain variant of lymphocyte function-associated antigen-1 (LFA-1) which targets intercellular adhesion molecule-1 (ICAM-1 or CD54), and the co-stimulatory signaling domains of CD28, 4-1BB (CD137) and CD3zeta, with potential immunostimulating and antineoplastic activities. Upon administration, autologous anti-ICAM-1-CAR-CD28-4-1BB-CD3zeta-expressing T-cells AIC100 recognize and kill ICAM-1-expressing tumor cells. ICAM-1, normally expressed on leukocytes and endothelial cells, may be overexpressed in a variety of cancers. CAR T-cells AIC100 are also engineered to express somatostatin receptor subtype 2 (SSTR2), allowing the imaging of the CAR T-cells in patients."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0004240", "l": "WF1 amacrine cell", "d": ["An amacrine cell with a wide dendritic field, dendrites in S1, and post-synaptic terminals in S1."]}]}
{"type": "biolink:Cell", "ic": "81.648881485605159", "identifiers": [{"i": "UMLS:C1881911", "l": "Mucinous Tall Columnar Adenocarcinoma Cell", "d": []}, {"i": "NCIT:C54690", "l": "Mucinous Tall Columnar Adenocarcinoma Cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5175603", "l": "Other cells | Blood cord | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4511887", "l": "Population of all epithelial cells in portion of fluid", "d": []}, {"i": "SNOMEDCT:726504009", "d": []}]}
{"type": "biolink:Cell", "ic": "78.185623981295834", "identifiers": [{"i": "CL:0000441", "l": "follicle stem cell (sensu Arthropoda)", "d": ["A stem cell that gives rise to the follicle cells that surround the oocyte in female arthropods."]}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "UMLS:C1519318", "l": "Signet Ring-Like Neoplastic T-Lymphocyte", "d": []}, {"i": "NCIT:C39683", "l": "Signet Ring-Like Neoplastic T-Lymphocyte", "d": []}]}
{"type": "biolink:Cell", "ic": "72.900487657105927", "identifiers": [{"i": "CL:0005014", "l": "auditory epithelial supporting cell", "d": ["A non-sensory cell that extends from the basement membrane to the apical surface of the auditory epithelium and provides support for auditory hair cells."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0001049", "l": "activated CD8-positive, alpha-beta T cell, human", "d": ["A recently activated CD8-positive, alpha-beta T cell with the phenotype HLA-DRA-positive, CD38-positive, CD69-positive, CD62L-negative, CD127-negative, CCR7-negative, and CD25-positive."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0000873", "l": "splenic metallophillic macrophage", "d": ["A splenic macrophage found in the areas surrounding the white pulp of the spleen, adjacent to the marginal sinus. Markers include F4/80-negative, Dectin2-low, sialoadhesin-positive."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5175605", "l": "Other cells | Cerebral spinal fluid | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "ic": "92.728541327098611", "identifiers": [{"i": "CL:1001145", "l": "interlobular vein cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5761403", "l": "Cell positive for estrogen receptor", "d": []}, {"i": "SNOMEDCT:1234915002", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1521882", "l": "WA07 cell line", "d": []}, {"i": "NCIT:C20309", "l": "WA07", "d": ["Provider: Wisconsin Alumni Research Foundation (WARF), Madison, WI. Information from provider and not independently verified by NIH: Cells are positive for cell markers SSEA-3, SSEA-4, TRA-1-60, TRA-1-81, and alkaline phosphatase; Cells are negative for SSEA-1; Give rise to teratomas containing derivatives of three germ layers in SCID mice; Differentiate in vitro. Cells not yet ready for distribution. Publication: Thomson et al., Science 282, 1145, 1998. This cell line meets the criteria for the use of human embryonic stem cells by federally funded researchers."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5669562", "l": "Azamidugene Autotemcel", "d": []}, {"i": "NCIT:C184823", "l": "Azamidugene Autotemcel", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1267931", "l": "Lymphocyte positive for CD45RB antigen", "d": []}, {"i": "SNOMEDCT:117374009", "d": []}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "UMLS:C2350466", "l": "Natural Killer T-Cells", "d": []}, {"i": "NCIT:C129906", "l": "Natural Killer T-Cell", "d": ["A subset of T-lymphocytes that coexpress an alpha/beta T-cell receptor, and variety of molecular markers that are typically associated with natural killer (NK) cells, which may include CD161, CD16, CD68, and granzyme. NK T-cells recognize glycolipids presented by antigen-presenting glycoprotein CD1d on antigen presenting cells; antigen recognition stimulates a rapid release of various cytokines from the NK T-cells."]}, {"i": "MESH:D055611", "l": "Natural Killer T-Cells", "d": []}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "CL:4030001", "l": "stromal cell of thymus", "d": ["A stromal cell that is part of the thymus."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2924222", "l": "Cells.CD11c-CD25+", "d": []}]}
{"type": "biolink:Cell", "ic": "73.976162571356099", "identifiers": [{"i": "UMLS:C0027883", "l": "Afferent neuron", "d": []}, {"i": "NCIT:C12628", "l": "Sensory Neuron", "d": ["An afferent neuron that converts environmental stimuli into electrical impulses that are transmitted to the central nervous system."]}, {"i": "MESH:D009475", "l": "Neurons, Afferent", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5206704", "l": "Autologous Anti-gp100CAR-CD3zeta-4-1BB-IL-15-PD1-expressing Tri-functional T-lymphocytes", "d": []}, {"i": "NCIT:C162626", "l": "Autologous Anti-gp100CAR-CD3zeta-4-1BB-IL-15-PD1-expressing Tri-functional T-lymphocytes", "d": ["A preparation of autologous T-lymphocytes that have been transduced with a lentiviral vector encoding a tri-functional chimeric antigen receptor (TriCAR) comprised of an extracellular domain consisting of an antigen binding domain specific to glycoprotein 100 (gp100) peptides 209-217 complexed with human leukocyte antigen A2 (HLA-A2), interleukin 15 (IL-15) and programmed cell death 1 (PD1; PDCD1; CD279; programmed death-1), which are linked by a transmembrane domain to the intracellular signaling domains of 4-1BB (CD137) and the zeta chain of the TCR/CD3 complex (TCRzeta; CD247; CD3zeta), with potential antineoplastic activity. Upon administration, the autologous anti-gp100CAR-CD3zeta-4-1BB-IL-15-PD1-expressing tri-functional T-lymphocytes selectively bind to gp100 peptides presented by HLA-A2. Upon binding to the gp100-HLA complex, the T-cells release cytokines and induce selective toxicity in gp100-expressing tumor cells. IL-15 is a pro-survival cytokine that promotes T-cell persistence and potentiates the immune response against tumor cells. The PD1 moiety binds to programmed cell death-1 ligand 1 (PD-L1; cluster of differentiation 274; CD274) on tumor cells, reversing T-cell inactivation caused by endogenous PD1/PD-L1 signaling and enhancing the cytotoxic T-lymphocyte (CTL)-mediated anti-tumor immune response against PD-L1-expressing tumor cells."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0882819", "l": "CD22+ cell", "d": []}, {"i": "SNOMEDCT:732269007", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157454", "l": "CD3+CD8+ (T8 suppressor) cells | Blood | Cell markers", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5216322", "l": "Unidentified cells|NCnc|Pt|Pericard fld", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0229892", "l": "Lymph lymphocyte", "d": []}, {"i": "SNOMEDCT:90385004", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2324943", "l": "Delayed type hypersensitivity-related T lymphocyte", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C4084782", "l": "4H11-28z/fIL-12/EGFRt-expressing Autologous T-lymphocytes", "d": []}, {"i": "NCIT:C123823", "l": "4H11-28z/fIL-12/EGFRt-expressing Autologous T-lymphocytes", "d": ["A preparation of genetically modified autologous T-lymphocytes transduced with a retroviral vector expressing a chimeric antigen receptor (CAR) targeting the human tumor-associated antigen (TAA) MUC16ecto and encoding the human pro-inflammatory cytokine interleukin-12 (IL-12), fused to the signaling domain of the zeta chain of the TCR/CD3 complex (28z), and a truncated form of the human epidermal growth factor receptor (EGFRt), with potential immunostimulating and antineoplastic activities. Upon intravenous administration, 4H11-28z/fIL-12/EGFRt-expressing autologous T-lymphocytes are directed to and induce selective toxicity in MUC16-expressing tumor cells. In addition, the T-cells secrete IL-12 which induces secretion of interferon-gamma, promotes the activation of natural killer cells (NKs), and induces cytotoxic T-cell responses against tumor cells, which may result in immune-mediated tumor cell death and inhibition of tumor cell proliferation. Devoid of both ligand binding domains and tyrosine kinase activity, the expressed EGFRt both facilitates in vivo detection of the administered, transduced T-cells and can promote elimination of those cells through a cetuximab-induced antibody-dependent cellular cytotoxicity (ADCC) response. MUC16, a transmembrane protein and glycosylated mucin, is overexpressed on the cell surface of the majority of ovarian cancer cells but not on healthy cells. MUC16ecto is the extracellular portion of MUC-16 and is the part that is retained by cells after cleavage of CA-125."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1517356", "l": "Geron H13 stem cell line", "d": []}, {"i": "NCIT:C20259", "l": "GE13", "d": ["Provider: Geron Corporation, Menlo Park, CA. No information from provider. This cell line meets the criteria for the use of human embryonic stem cells by federally funded researchers."]}]}
{"type": "biolink:Cell", "ic": "90.82444074280258", "identifiers": [{"i": "CL:0002345", "l": "CD27-low, CD11b-low immature natural killer cell, mouse", "d": ["An immature natural killer cell that is NK1.1-positive, DX5-positive, Ly49-positive, CD27-low and CD11b-low. This cell type is found in high numbers in the liver."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5174860", "l": "Nonhematic cells | Body fluid | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C3495621", "l": "A15 dopamine cells", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002528", "l": "mature CD14-positive dermal dendritic cell", "d": ["A mature CD14-positive dermal dendritic cell is CD80-high, CD86-high, MHCII-high and is CD83-positive."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2359895", "l": "Platelets.reticulated", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1979663", "l": "Cell positive for BCLXL protein", "d": []}, {"i": "SNOMEDCT:725314007", "d": []}]}
{"type": "biolink:Cell", "ic": "86.236661114203869", "identifiers": [{"i": "UMLS:C1514000", "l": "Neoplastic Large Cell with Abundant Pale Cytoplasm", "d": []}, {"i": "NCIT:C37163", "l": "Neoplastic Large Cell with Abundant Pale Cytoplasm", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1979639", "l": "Blasts.CD21", "d": []}]}
{"type": "biolink:Cell", "ic": "90.82444074280258", "identifiers": [{"i": "UMLS:C1517170", "l": "Fibrillary Neoplastic Astrocyte", "d": []}, {"i": "NCIT:C37129", "l": "Fibrillary Neoplastic Astrocyte", "d": ["A neoplastic astrocyte characterized by the presence of an atypical nucleus (large, irregular, or hyperchromatic), scant amount of cytoplasm, and cell processes that contribute to the formation of a fibrillary matrix."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0029045", "l": "Oocytes", "d": []}, {"i": "MESH:D009865", "l": "Oocytes", "d": []}, {"i": "SNOMEDCT:86082002", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1182709", "l": "Epithelial cell of stratum spinosum of esophagus", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5173438", "l": "Monocytes | Synovial fluid | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5708042", "l": "Anti-PSMA/Anti-CD70 4SCAR-expressing Bispecific T-cells", "d": []}, {"i": "NCIT:C188802", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5216200", "l": "Eosinophils|NCnc|Pt|Body fld", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1317194", "l": "Cells.CD235a", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2953987", "l": "Type D cell of colon", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5707291", "l": "Autologous IL-15-expanded HER2-specific CD4+ T-cells", "d": []}, {"i": "NCIT:C187685", "l": "Autologous IL-15-expanded HER2-specific CD4+ T-cells", "d": ["A preparation of autologous, interleukin-15 (IL-15)-expanded, human epidermal growth factor receptor 2 (EGFR2; HER2; ErbB2)-specific, cluster of differentiation 4 (CD4)-positive T-lymphocytes, with potential immunostimulating and antineoplastic activities. Autologous HER2-specific CD4+ T-cells are expanded ex vivo with IL-15. Upon reintroduction into the patient, the autologous IL-15-expanded HER2-specific CD4+ T-cells recognize and stimulate a T-cell-mediated immune response against HER2-expressing tumor cells. HER2, a receptor tyrosine kinase (RTK) mutated or overexpressed in many tumor cell types, plays a key role in tumor cell proliferation and tumor vascularization. IL-15 is a cytokine that enhances T-cell expansion."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4759709", "l": "Meiotic cell", "d": []}, {"i": "SNOMEDCT:55164002", "d": []}]}
{"type": "biolink:Cell", "ic": "90.82444074280258", "identifiers": [{"i": "CL:0001047", "l": "CD4-positive, CD25-positive, CCR4-positive, alpha-beta regulatory T cell", "d": ["A CD4-positive, CD25-positive, alpha-beta regulatory T cell with the additional phenotype CCR4-positive."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2329779", "l": "Enterocyte of epithelium proper of small intestine", "d": []}]}
{"type": "biolink:Cell", "ic": "77.061101857006449", "identifiers": [{"i": "CL:0000477", "l": "follicle cell of egg chamber", "d": ["A somatic epithelial cell of the insect egg chamber."]}]}
{"type": "biolink:Cell", "ic": "67.484282358461357", "identifiers": [{"i": "UMLS:C1513962", "l": "Neoplastic Epithelial Spindle Cell", "d": []}, {"i": "NCIT:C36849", "l": "Neoplastic Epithelial Spindle Cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1440407", "l": "Cells.t(15;17)(q24.1;q21.1)(PML,RARA)", "d": []}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "CL:4023045", "l": "medulla-projecting glutamatergic neuron of the primary motor cortex", "d": ["An extratelencephalic-projecting glutamatergic neuron located in layer 5b of the primary motor cortex that projects to the medulla. MY ET cells are large, big-tufted cells with the apical dendrite often bifurcating close to the soma, suggesting they are corticospinal cells. MY ET cells have bigger hyperpolarization sag, lower input resistance, and smaller AP width, compared to L5 IT neurons."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0001080", "l": "NKp44-negative group 3 innate lymphoid cell, human", "d": ["A group 3 innate lymphoid cell in the human with the phenotype IL-7Ralpha-positive, and NKp44-negative."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C4086555", "l": "M2 Macrophage", "d": []}, {"i": "NCIT:C123783", "l": "M2 Macrophage", "d": ["A macrophage that produces high levels of interleukin (IL)-10, TGF-beta and low levels of IL-12 and converts arginine to ornithine. These cells may both encourage tissue repair and inhibit inflammation."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4727630", "l": "ciltacabtagene autoleucel", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2924459", "l": "Lymphocytes.variant", "d": []}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "UMLS:C1517098", "l": "FSH Cells", "d": []}, {"i": "NCIT:C32641", "l": "FSH Cell", "d": ["A basophilic cell of the anterior pituitary gland whose granules secrete follicle-stimulating hormone"]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:4023052", "l": "Betz upper motor neuron", "d": ["A Betz cell that synapses with lower motor neurons directly."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5706543", "l": "Autologous Enhanced NY-ESO-1 TCR Engineered T-cells GSK4427296", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0003047", "l": "M14 retinal ganglion cell", "d": ["A bistratifed retinal ganglion cell that has small, symmetric dendritic fields that terminate in S1 and S4-S5."]}]}
{"type": "biolink:Cell", "ic": "90.82444074280258", "identifiers": [{"i": "UMLS:C1709171", "l": "Neoplastic Eosinophilic Precursor", "d": []}, {"i": "NCIT:C43232", "l": "Neoplastic Eosinophilic Precursor", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157273", "l": "CD11c+CD103+ cells | Blood | Cell markers", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4737460", "l": "terminal deoxyribonucleotidyl transferase cells per 100 cells", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5173443", "l": "Monocytes.immature/100 leukocytes | Blood | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4072762", "l": "Cells.CCND1 gene", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:1000469", "l": "myoepithelial cell of main lactiferous duct", "d": ["A myoepithelial cell that is part of the main lactiferous duct."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1515996", "l": "Anti-gp100 TCR Retroviral Vector-Transduced Autologous PBL", "d": []}, {"i": "NCIT:C38136", "l": "Anti-gp100 TCR Retroviral Vector-Transduced Autologous PBL", "d": ["Human peripheral blood lymphocytes (PBL) isolated from a melanoma patient and were engineered to react with the melanoma antigen glycoprotein 100 (gp100). These PBL are transduced with a retroviral pGCsam vector encoding T-cell receptors specific for gp100, grown in culture, and then transferred back to the patient. These genetically modified PBL may recognize and halt the growth of gp100-expressing melanoma cells."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157397", "l": "CD22+CD19+ | White blood cells | Cell markers", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1516096", "l": "B-Immunoblast", "d": []}, {"i": "NCIT:C34033", "l": "B-Immunoblast", "d": ["A B-lymphocyte that has been transformed (activated) in response to antigenic stimulation."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5220581", "l": "Erythrocytes|Urine/Urine sed", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C3496529", "l": "A14 dopamine cells", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4518155", "l": "Population of all spermatozoa with abnormal midpiece in portion of fluid", "d": []}, {"i": "SNOMEDCT:725226000", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0000877", "l": "splenic tingible body macrophage", "d": ["A splenic white pulp macrophage found in and around the germinal centers of the white pulp of the spleen that participates in phagocytosis of apoptotic B cells from the germinal centers. A marker for a cell of this type is Mertk-positive."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0009053", "l": "stromal cell of anorectum lamina propria", "d": ["A stromal cell found in the lamina propria of the anorectum."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4763340", "l": "Anaxonic neuron", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0882939", "l": "CD8+HLA-DR+ cell", "d": []}, {"i": "SNOMEDCT:732282004", "d": []}]}
{"type": "biolink:Cell", "ic": "64.865813367930599", "identifiers": [{"i": "CL:0001060", "l": "hematopoietic oligopotent progenitor cell, lineage-negative", "d": ["A hematopoietic oligopotent progenitor cell that has the ability to differentiate into limited cell types but lacks lineage cell markers and self renewal capabilities. Cell lacks hematopoeitic lineage markers."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1651663", "l": "Cells.CD20+CD23+", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1182647", "l": "Non-pigmented ciliary epithelial cell", "d": []}]}
{"type": "biolink:Cell", "ic": "76.857431420584163", "identifiers": [{"i": "UMLS:C1709200", "l": "Neoplastic Small to Medium-Sized B-Lymphocyte Resembling a Centrocyte", "d": []}, {"i": "NCIT:C45310", "l": "Neoplastic Small to Medium-Sized B-Lymphocyte Resembling a Centrocyte", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5212794", "l": "Chromosome 12 copy number", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1184876", "l": "Internal pillar cell of cochlea", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5669563", "l": "Firolimogene Autotemcel", "d": []}, {"i": "NCIT:C184824", "l": "Firolimogene Autotemcel", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002133", "l": "stromal cell of ovarian cortex", "d": ["A stromal cell of the ovarian cortex."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1183358", "l": "Type-2 epithelial cell of thymus", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5706377", "l": "Allogeneic Nicotinamide-expanded Natural Killer Cells GDA-201", "d": []}, {"i": "NCIT:C187130", "l": "Allogeneic Nicotinamide-expanded Natural Killer Cells GDA-201", "d": ["A preparation of allogeneic, nicotinamide (NAM)-expanded natural killer (NK) cells, with potential cytolytic and antineoplastic activities. Upon administration, the allogeneic NAM-expanded NK cells GDA-201 may lyse cancer cells. These cells also secrete pro-inflammatory cytokines, which further stimulate an anti-tumor immune response. Ex-vivo treatment with the vitamin B3 derivative NAM increases the in-vivo homing, retention and proliferation potential of the NK cells."]}]}
{"type": "biolink:Cell", "ic": "74.37742281270377", "identifiers": [{"i": "CL:1000500", "l": "kidney interstitial cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1180059", "l": "Nucleated cell", "d": []}]}
{"type": "biolink:Cell", "ic": "92.728541327098611", "identifiers": [{"i": "CL:0000388", "l": "tendon cell", "d": ["An elongated fibrocyte that is part of a tendon. The cytoplasm is stretched between the collagen fibres of the tendon. They have a central cell nucleus with a prominent nucleolus. Tendon cells have a well-developed rough endoplasmic reticulum and they are responsible for synthesis and turnover of tendon fibres and ground substance."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2330894", "l": "Retinal pigment epithelial cell", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002439", "l": "NKGA2-positive natural killer cell, mouse", "d": ["A NK1.1-positive T cell that is NKGA2-positive."]}]}
{"type": "biolink:Cell", "ic": "57.171286305718318", "identifiers": [{"i": "CL:0002076", "l": "endo-epithelial cell", "d": ["An epithelial cell derived from endoderm."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4511890", "l": "Population of all burr cells in portion of fluid", "d": []}, {"i": "SNOMEDCT:726507002", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0009000", "l": "sensory neuron of spinal nerve", "d": ["A sensory neuron of the spinal nerve that senses body position and sends information about how much the muscle is stretched to the spinal cord."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0000880", "l": "choroid-plexus macrophage", "d": ["A central nervous system macrophage found at the interface between the blood and the cerebrospinal fluid in the brain. This cell expresses scavenger receptors."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157334", "l": "CD16-CD57- | White blood cells | Cell markers", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0009079", "l": "thymic fibroblast type 2", "d": ["A fibroblast located between thymic lobules."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5235879", "l": "EBV Immortalized Lymphocytes", "d": []}, {"i": "NCIT:C163993", "l": "EBV Immortalized Lymphocytes", "d": ["A biospecimen consisting of lymphocytes that have been isolated from whole blood and are then infected in vitro by Epstein-Barr virus (EBV; HHV4). The infected cells are then cultured to select indefinitely proliferating colonies that can be maintained in tissue culture."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0043036", "l": "Warthin-Finkeldey giant cell", "d": []}, {"i": "SNOMEDCT:54943009", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5172505", "l": "Mesothelial cells | Pericardial fluid | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4684874", "l": "P-BCMA-101", "d": []}]}
{"type": "biolink:Cell", "ic": "80.511444690059548", "identifiers": [{"i": "CL:0000670", "l": "primordial germ cell", "d": ["A primordial germ cell is a diploid germ cell precursors that transiently exist in the embryo before they enter into close association with the somatic cells of the gonad and become irreversibly committed as germ cells."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5666897", "l": "Allogeneic Variable Delta 1 Gamma-delta T-lymphocytes GDX012", "d": []}, {"i": "NCIT:C182633", "l": "Allogeneic Variable Delta 1 Gamma-delta T-lymphocytes GDX012", "d": ["An off-the-shelf (OTS) preparation of allogeneic variable delta 1 (Vd1) gamma-delta (gd) T-lymphocytes, with potential immunomodulating and antineoplastic activities. Upon administration of the allogeneic Vd1 gd T-lymphocytes GDX012, these cells secrete interferon-gamma (IFN-g) and exert direct killing of tumor cells. In addition, these cells activate the immune system to exert a cytotoxic T-lymphocyte (CTL) response against tumor cells. Gamma delta T-lymphocytes play a key role in the activation of the immune system and do not require major histocompatibility complex (MHC)-mediated antigen presentation to exert their cytotoxic effect. Vd1 gd T-cells, a subset of gamma delta T-cells, recognize and are activated by cancer cells, and may therefore have a stronger association with antitumor immune responses compared with other gamma delta T-cell subtypes."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2323993", "l": "Epithelial cell of bile duct", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C0033416", "l": "Promyelocytes", "d": []}, {"i": "NCIT:C13114", "l": "Promyelocyte", "d": ["A cell of the bone marrow that is derived from myeloblasts and will give rise to myelocytes, precursors of myeloid cells and neutrophil granulocytes."]}, {"i": "SNOMEDCT:43446009", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002102", "l": "CD38-negative naive B cell", "d": ["A CD38-negative naive B cell is a mature B cell that has the phenotype CD38-negative, surface IgD-positive, surface IgM-positive, and CD27-negative, that has not yet been activated by antigen in the periphery."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0003006", "l": "G4-ON retinal ganglion cell", "d": ["A G4 retinal ganglion cell that has post sympatic terminals in sublaminar layers S3 and S4 and is depolarized by illumination of its receptive field center."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4331902", "l": "Immuncell-LC", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2332313", "l": "Type 2B muscle fiber", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0034964", "l": "Regenerating muscle fiber", "d": []}, {"i": "SNOMEDCT:56132000", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002394", "l": "CD141-positive myeloid dendritic cell", "d": ["A myeloid dendritic cell found in the blood, lymph nodes, tonsil, bone marrow, and spleen that is CD141-positive (BDCA-3), XCR1-positive, and Clec9A-positive. This cell-type can cross-present antigen to CD8-positive T cells and can produce inteferon-beta."]}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "CL:0002109", "l": "B220-positive CD38-positive naive B cell", "d": ["A B220-positive CD38-positive naive B cell is a CD38-positive naive B cell that has the phenotype B220-positive, CD38-positive, surface IgD-positive, surface IgM-positive, and CD27-negative, and that has not yet been activated by antigen in the periphery."]}]}
{"type": "biolink:Cell", "ic": "79.541110464886842", "identifiers": [{"i": "CL:0000092", "l": "osteoclast", "d": ["A specialized phagocytic cell associated with the absorption and removal of the mineralized matrix of bone tissue, which typically differentiates from monocytes. This cell has the following markers: tartrate-resistant acid phosphatase type 5-positive, PU.1-positive, c-fos-positive, nuclear factor NF-kappa-B p100 subunit-positive, tumor necrosis factor receptor superfamily member 11A-positive and macrophage colony-stimulating factor 1 receptor-positive."]}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "CL:1000383", "l": "type 2 vestibular sensory cell of epithelium of macula of utricle of membranous labyrinth", "d": ["A type II vestibular sensory cell that is part of the epithelium of macula of utricle of membranous labyrinth."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0947287", "l": "CD16 cells", "d": []}]}
{"type": "biolink:Cell", "ic": "92.728541327098611", "identifiers": [{"i": "UMLS:C1514035", "l": "Neoplastic Myeloblast with Abundant Basophilic Cytoplasm", "d": []}, {"i": "NCIT:C37176", "l": "Neoplastic Myeloblast with Abundant Basophilic Cytoplasm", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1516091", "l": "Atypical Ductal Epithelial Cell", "d": []}, {"i": "NCIT:C36883", "l": "Atypical Ductal Epithelial Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "UMLS:C1514097", "l": "Neoplastic Small to Medium-Sized T-Lymphocyte with Irregular Nucleus", "d": []}, {"i": "NCIT:C39681", "l": "Neoplastic Small to Medium-Sized T-Lymphocyte with Irregular Nucleus", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002244", "l": "squamous cell of ectocervix", "d": ["A nonstratified squamous cell located in the ectocervix."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4322669", "l": "CD56+ NK lymphocyte", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157547", "l": "CD4+CD45RA+CD45RB+CD45RC+ cells | Cerebral spinal fluid | Cell markers", "d": []}]}
{"type": "biolink:Cell", "ic": "72.473322228407739", "identifiers": [{"i": "CL:0000152", "l": "exocrine cell", "d": ["A cell of an exocrine gland; i.e. a gland that discharges its secretion via a duct."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4323726", "l": "Trunk neural crest cell group", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0022827", "l": "L Cells", "d": []}, {"i": "MESH:D007739", "l": "L Cells", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:4030005", "l": "kidney collecting duct beta-intercalated cell", "d": ["A renal beta-intercalated cell that is part of the cortical collecting duct. The medullary collecting duct does not contain the renal beta-intercalated cell type."]}]}
{"type": "biolink:Cell", "ic": "92.728541327098611", "identifiers": [{"i": "CL:1001142", "l": "arcuate vein cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2322913", "l": "Transitional myocyte of ventricular part of atrioventricular bundle", "d": []}]}
{"type": "biolink:Cell", "ic": "60.949954571375002", "identifiers": [{"i": "UMLS:C1708915", "l": "Malignant Spindle Cell", "d": []}, {"i": "NCIT:C53637", "l": "Malignant Spindle Cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5172507", "l": "Mesothelial cells | Pleural fluid | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "ic": "84.75972595860604", "identifiers": [{"i": "CL:0010008", "l": "cardiac endothelial cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5706516", "l": "Engineered Red Blood Cells Expressing 4-1BBL/IL-12 RTX-224", "d": []}, {"i": "NCIT:C188894", "d": []}]}
{"type": "biolink:Cell", "ic": "89.347505587204751", "identifiers": [{"i": "CL:0000562", "l": "nucleate erythrocyte", "d": ["An erythrocyte having a nucleus."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C4683874", "l": "Atypical Glandular Cell-Favor Neoplasia", "d": []}, {"i": "NCIT:C141517", "l": "Atypical Glandular Cell-Favor Neoplasia", "d": ["An abnormal endocervical or endometrial cell found in a cervical smear with cytologic features suggestive of a neoplastic process."]}]}
{"type": "biolink:Cell", "ic": "83.023198044254755", "identifiers": [{"i": "CL:0011108", "l": "colon epithelial cell", "d": ["Epithelial cell that is part of the colon epithelium."]}]}
{"type": "biolink:Cell", "ic": "78.695011174409487", "identifiers": [{"i": "CL:0005024", "l": "somatomotor neuron", "d": ["A motor neuron that innervates a skeletal muscle.  These motor neurons are all excitatory and cholinergic."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1441341", "l": "100 erythrocytes", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C0524983", "l": "Gastrin-Secreting Cells", "d": []}, {"i": "NCIT:C12577", "l": "G-Cell", "d": ["A gastrin-producing enteroendocrine cell that is located in the gastric antrum."]}, {"i": "MESH:D019863", "l": "Gastrin-Secreting Cells", "d": []}]}
{"type": "biolink:Cell", "ic": "83.552982069901191", "identifiers": [{"i": "UMLS:C1513944", "l": "Neoplastic Corticotroph Cell", "d": []}, {"i": "NCIT:C36920", "l": "Neoplastic Corticotroph Cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1267941", "l": "Lymphocyte positive for CD49F antigen", "d": []}, {"i": "SNOMEDCT:117384005", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C3829191", "l": "MART-1/gp100/Tyrosinase/MAGE-A3 Peptides-loaded Irradiated Allogeneic Plasmacytoid Dendritic Cells", "d": []}, {"i": "NCIT:C107159", "l": "MART-1/gp100/Tyrosinase/MAGE-A3 Peptides-loaded Irradiated Allogeneic Plasmacytoid Dendritic Cells", "d": ["Irradiated allogeneic, HLA-A*0201 positive, plasmacytoid dendritic cells (pDCs) loaded with 4 melanoma peptides derived from the tumor associated antigens (TAAs) MelA/MART-1, gp100/pmel17, tyrosinase, and MAGE-A3, with potential immunostimulating and antineoplastic activities. Upon subcutaneous administration, the irradiated allogeneic pDCs may trigger functional multi-specific T cells from peripheral blood mononuclear cells and tumor-infiltrating lymphocytes, and activate the immune system to mount a cytotoxic T-lymphocyte response against HLA-A*0201 positive melanoma cancer cells expressing the TAAs MelA/MART-1, gp100/pmel17, tyrosinase, and MAGE-A3. These TAAs are upregulated in a variety of tumor cells. The pDCs are derived from a distinct subset of dendritic cells (DCs) with a plasma cell-like morphology and express a characteristic set of surface markers and may increase the anti-tumor immune responses."]}]}
{"type": "biolink:Cell", "ic": "80.17194633000733", "identifiers": [{"i": "CL:0002633", "l": "respiratory basal cell", "d": ["A basal cell in the respiratory tract."]}]}
{"type": "biolink:Cell", "ic": "85.457082654197222", "identifiers": [{"i": "CL:1001036", "l": "vasa recta cell", "d": []}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "CL:0000430", "l": "xanthophore cell", "d": ["A pigment cell derived from the neural crest. Contains cartenoid pigments in structures called pterinosomes or xanthosomes. This gives an appearance ranging from a golden yellow to orange and red."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1267928", "l": "Lymphocyte positive for CD45 antigen", "d": []}, {"i": "SNOMEDCT:116853007", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1513814", "l": "NC01", "d": []}, {"i": "NCIT:C20281", "l": "NC01", "d": ["Provider: National Centre for Biological Sciences/ Tata Institute of Fundamental Research, Bangalore, India. No information from provider. This cell line meets the criteria for the use of human embryonic stem cells by federally funded researchers."]}]}
{"type": "biolink:Cell", "ic": "89.347505587204751", "identifiers": [{"i": "CL:0002014", "l": "Kit-negative, Ly-76 high basophilic erythroblast", "d": ["A basophilic erythroblast that is Lyg 76-high and is Kit-negative."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0427529", "l": "Smear cell", "d": []}, {"i": "SNOMEDCT:250288005", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5382941", "l": "Interferon-gamma producing HLA-B35 Cytomegalovirus specific CD8 cells | Blood | Cell markers", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1267809", "l": "Lymphocyte negative for surface membrane immunoglobulin and positive for CD79 antigen", "d": []}, {"i": "SNOMEDCT:117513006", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5708809", "l": "Dust Vitreous Seed", "d": []}, {"i": "NCIT:C189885", "d": []}]}
{"type": "biolink:Cell", "ic": "80.17194633000733", "identifiers": [{"i": "UMLS:C1707879", "l": "Eccrine Cell", "d": []}, {"i": "NCIT:C43373", "l": "Eccrine Cell", "d": ["A secretory cell that discharges its product without loss of cytoplasm."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0011032", "l": "lysosome-rich enterocyte", "d": ["An enterocyte that possesses a large supranuclear vacuolar system that preferentially internalizes dietary protein via receptor-mediated and fluid-phase endocytosis for intracellular digestion and trans-cellular transport. In zebrafish these cells are located in the posterior region of the mid intestine throughout life. In mammals they are found in the ileum pre-weaning and later are replaced by mature enterocytes."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:1000803", "l": "kidney inner medulla interstitial cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5154478", "l": "Basophils | Fetus | Blood | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5205962", "l": "Autologous Anti-SLAMF7 CAR-expressing T-cells", "d": []}, {"i": "NCIT:C161635", "l": "Autologous Anti-SLAMF7 CAR-expressing T-cells", "d": ["A preparation of autologous T-lymphocytes that have been genetically modified to express a chimeric antigen receptor (CAR) recognizing human SLAM family member 7 (SLAMF7; CD319 CRACC; CS-1) with potential antineoplastic activity. Upon intravenous administration, the autologous anti-SLAMF7 CAR-expressing T-cells target and induce selective toxicity in SLAMF7-expressing tumor cells. SLAMF7 is a member of the signaling lymphocytic activation molecule (SLAM) family of transmembrane receptors that modulate the function of immune cells through immunoreceptor tyrosine-based switch motifs (ITSMs) and intracellular adaptor proteins. SLAMF7 is highly expressed on certain malignant plasma cells and is minimally expressed on healthy immune cells."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2331959", "l": "Set of cholinergic cells of amygdaloid body [Ch4]", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5169606", "l": "Irregularly contracted cells | Blood | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:1000424", "l": "chromaffin cell of paraaortic body", "d": ["A chromaffin cell that is part of the paraaortic body."]}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "CL:0000661", "l": "distal tip cell (sensu Nematoda)", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:1000381", "l": "type 1 vestibular sensory cell of epithelium of crista of ampulla of semicircular duct of membranous labyrinth", "d": ["A type I vestibular sensory cell that is part of the epithelium of crista of ampulla of semicircular duct of membranous labyrinth."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1512505", "l": "Breast Cancer Cell", "d": []}, {"i": "NCIT:C12959", "l": "Breast Cancer Cell", "d": ["Cells found in human breast cancers or extracted from cancers as established cell lines"]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5170934", "l": "Leukocytes | Peritoneal fluid | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1440364", "l": "Cells.CD87", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1440395", "l": "Cells.SmIg", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C3179111", "l": "Feeder Layer Cells", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2338473", "l": "Transitional myocyte of atrial branch of anterior internodal tract", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1514657", "l": "RL13", "d": []}, {"i": "NCIT:C20291", "l": "RL13", "d": ["Provider: Reliance Life Sciences, Mumbai, India. No information from provider. This cell line meets the criteria for the use of human embryonic stem cells by federally funded researchers."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1267842", "l": "Lymphocyte positive for both CD4 antigen and CD69 antigen", "d": []}, {"i": "SNOMEDCT:117529003", "d": []}]}
{"type": "biolink:Cell", "ic": "69.071635092918072", "identifiers": [{"i": "CL:4023017", "l": "sst GABAergic cortical interneuron", "d": ["A GABAergic neuron located in the cerebral cortex that expresses somatostatin (sst)"]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5708221", "l": "Anti-CD19/Anti-CD79b 4SCAR-expressing Bispecific T-cells", "d": []}, {"i": "NCIT:C189059", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0028876", "l": "Odontoclasts", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5170951", "l": "Leukocytes other | Body fluid | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1258005", "l": "HCT116 Cells", "d": []}, {"i": "MESH:D045325", "l": "HCT116 Cells", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5432279", "l": "Allocetra", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C4687585", "l": "Autologous PBLs Retrovirally-transduced with TCRs Targeting Neoantigens", "d": []}, {"i": "NCIT:C146937", "l": "Autologous PBLs Retrovirally-transduced with TCRs Targeting Neoantigens", "d": ["Autologous human peripheral blood lymphocytes (PBLs) transduced with a retroviral vector encoding T-cell receptors (TCRs) specific for a patient's individual and unique mutated antigens, with potential immunostimulating and antineoplastic activities. Tumor cells are analyzed to identify and isolate specific mutated tumor-associated antigens (TAAs) that are expressed by the patient's tumor cells; then T-cell receptor coding sequences are engineered to target the patient's TAAs and inserted into retroviral vectors. After transduction, expansion in culture, and reintroduction into the patient, neoantigen-specific TCRs retroviral vector-transduced autologous PBLs recognize and bind to tumor cells expressing the patient's neoantigens, which results in a specific cytotoxic T-lymphocyte (CTL)-mediated immune response against the patient's tumor cells."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1267899", "l": "Lymphocyte positive for CD26 antigen", "d": []}, {"i": "SNOMEDCT:117570001", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5173499", "l": "Mononuclear cells | Pleural fluid | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "ic": "75.58416670140862", "identifiers": [{"i": "CL:0000239", "l": "brush border epithelial cell", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0000879", "l": "meningeal macrophage", "d": ["A central nervous system macrophage found in the meninges (the three membranes that surround the brain). This macrophage types is highly phagocytic and expresses scavenger receptors."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0333807", "l": "Macrocytic hyperchromic erythrocyte", "d": []}, {"i": "SNOMEDCT:23305007", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0682542", "l": "ciliated cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2333370", "l": "Serous cell of epithelium of terminal bronchiole", "d": []}]}
{"type": "biolink:Cell", "ic": "90.82444074280258", "identifiers": [{"i": "CL:0007005", "l": "notochordal cell", "d": ["Cell that is part of the notochord."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1955383", "l": "Spermatozoa.isolated head", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5216258", "l": "Macrophages|NCnc|Pt|Synv fld", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C3179121", "l": "Human Umbilical Vein Endothelial Cells", "d": []}, {"i": "MESH:D061307", "l": "Human Umbilical Vein Endothelial Cells", "d": []}]}
{"type": "biolink:Cell", "ic": "89.347505587204751", "identifiers": [{"i": "UMLS:C1709197", "l": "Neoplastic Schwann-Like Cell", "d": []}, {"i": "NCIT:C48594", "l": "Neoplastic Schwann-Like Cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2326151", "l": "Set of erythrocytes", "d": []}]}
{"type": "biolink:Cell", "ic": "70.441195081532641", "identifiers": [{"i": "CL:0011110", "l": "histaminergic neuron", "d": ["Neuron that secretes histamine."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1514659", "l": "RL20", "d": []}, {"i": "NCIT:C20293", "l": "RL20", "d": ["Provider: Reliance Life Sciences, Mumbai, India. No information from provider. This cell line meets the criteria for the use of human embryonic stem cells by federally funded researchers."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C3176904", "l": "Cells.CD3+CD5+", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5420769", "l": "Anti-CD4 CAR T-cells", "d": []}, {"i": "NCIT:C174420", "l": "Anti-CD4 CAR T-cells", "d": ["A preparation of T-lymphocytes that have been genetically modified and transduced with a lentiviral vector expressing a chimeric antigen receptor (CAR) targeting the tumor-associated antigen (TAA) CD4 and containing, as of yet undisclosed co-stimulatory signaling domains, with potential immunostimulating and antineoplastic activities. Upon administration, anti-CD4 CAR T-cells target and bind to CD4-expressing tumor cells, thereby inducing selective toxicity in CD4-expressing tumor cells. CD4 antigen is expressed in CD4-positive T cell lymphomas."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1179009", "l": "Retinal pigment cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C3476509", "l": "Siderophages", "d": []}]}
{"type": "biolink:Cell", "ic": "56.086908212148579", "identifiers": [{"i": "UMLS:C0229525", "l": "Endocrine Cells", "d": []}, {"i": "NCIT:C32506", "l": "Endocrine Cell", "d": []}, {"i": "MESH:D055098", "l": "Endocrine Cells", "d": []}, {"i": "SNOMEDCT:68233007", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4322825", "l": "CD8+CD57+ T Lymphocyte", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4072759", "l": "Cells.MYB gene", "d": []}]}
{"type": "biolink:Cell", "ic": "49.547364005310641", "identifiers": [{"i": "CL:0000006", "l": "neuronal receptor cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1267966", "l": "Lymphocyte positive for CD72 antigen", "d": []}, {"i": "SNOMEDCT:117406009", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1622561", "l": "lateral part of motile cell", "d": []}]}
{"type": "biolink:Cell", "ic": "88.140761698499901", "identifiers": [{"i": "CL:0000793", "l": "CD4-positive, alpha-beta intraepithelial T cell", "d": ["A CD4-positive, alpha-beta T cell that is found in the columnar epithelium of the gastrointestinal tract."]}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "CL:0000712", "l": "stratum granulosum cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0596713", "l": "horizontal cell", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C4727561", "l": "Autologous NY-ESO-1-redirected CRISPR-edited T Cells", "d": []}, {"i": "NCIT:C154288", "l": "Autologous NY-ESO-1-redirected CRISPR-edited T Cells", "d": ["A preparation of human autologous T-lymphocytes that are transduced with a lentiviral vector (LV) encoding a T-cell receptor (TCR) specific for the tumor-associated antigen (TAA) cancer-testis antigen NY-ESO-1 and gene-edited with the clustered regularly interspaced short palindromic repeats (CRISPR)-Cas9 nuclease complex to eliminate endogenous TCR and programmed cell death 1 (PD-1) expression, with potential immunostimulating and antineoplastic activities. The CRISPR guide RNA (gRNA) specifically targets and binds to complementary sites on TCRalpha, TCRbeta and PD-1. In turn, Cas9 cleaves these specific DNA sites, thereby disrupting transcription. Upon isolation, transduction, electroporation with TCRalpha, TCRbeta and PD-1 gRNAs which are complexed to Cas9 RNA to disrupt expression of endogenous TCRalpha, TCRbeta and PD-1, expansion ex vivo, and reintroduction into the patient, the anti-NY-ESO-1 TCR LV-transduced CRISPR-edited autologous T-cells recognize and bind to NY-ESO-1-overexpressing tumor cells. This may result in a specific cytotoxic T-lymphocyte (CTL)-mediated killing of NY-ESO-1-positive tumor cells. NY-ESO-1, a tumor-associated antigen (TAA), is found in normal testis and on the surface of various tumor cell types, and is not, or is minimally, expressed in normal, healthy cells. PD-1, an immune checkpoint receptor expressed on T-cells, plays a key role in tumor immune evasion by binding to its ligand programmed cell death ligand 1 (PD-L1) expressed on tumor cells. By removing PD-1 from T-cells, PD-1-mediated signaling is halted which may decrease T-cell exhaustion and may enhance T-cell activity against the NY-ESO-1-expressing tumor cells. Removal of endogenous TCR reduces TCR competition for expression, increases the persistence and function of the expressed transgenic TCR, enhances resistance to T-cell exhaustion and increases T-cell activity."]}]}
{"type": "biolink:Cell", "ic": "54.279177875818114", "identifiers": [{"i": "CL:0000031", "l": "neuroblast (sensu Vertebrata)", "d": ["A cell that will develop into a neuron often after a migration phase."]}]}
{"type": "biolink:Cell", "ic": "87.120474278337809", "identifiers": [{"i": "UMLS:C1517654", "l": "Karolinska ES Cell Line", "d": []}, {"i": "NCIT:C20267", "l": "Karolinska ES Cell Line", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5545270", "l": "Virtual Memory T Cells", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0014802", "l": "Erythroid Precursor Cells", "d": []}, {"i": "MESH:D015672", "l": "Erythroid Precursor Cells", "d": []}, {"i": "SNOMEDCT:304601009", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1518889", "l": "Paraimmunoblast", "d": []}, {"i": "NCIT:C36989", "l": "Paraimmunoblast", "d": []}]}
{"type": "biolink:Cell", "ic": "77.061101857006449", "identifiers": [{"i": "CL:0000069", "l": "branched duct epithelial cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5186221", "l": "Eosinophils | Fetus | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:4033041", "l": "CCL3-positive alveolar macrophage", "d": ["An alveolar macrophage that expresses CCL3."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1881196", "l": "Indium In 111-Labeled Autologous Polymorphonuclear Leukocytes", "d": []}, {"i": "NCIT:C67086", "l": "Indium In 111-Labeled Autologous Polymorphonuclear Leukocytes", "d": ["A preparation of autologous peripheral polymorphonuclear (PMNLs) radiolabeled with indium In 111 with radioisotopic activity. Autologous PMNLs are isolated, expanded ex vivo, radiolabeled with indium In 111, and then infused back into the patient. Gamma scintigraphy may then be used to image gamma ray-emitting indium In 111 PMNLs localized in lymphoma tissue."]}]}
{"type": "biolink:Cell", "ic": "74.240948556675605", "identifiers": [{"i": "CL:0000653", "l": "podocyte", "d": ["A specialized kidney epithelial cell, contained within a glomerulus, that contains \"feet\" that interdigitate with the \"feet\" of other podocytes."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1267964", "l": "Lymphocyte positive for CD69 antigen", "d": []}, {"i": "SNOMEDCT:117405008", "d": []}]}
{"type": "biolink:Cell", "ic": "80.511444690059548", "identifiers": [{"i": "CL:0004247", "l": "bistratified cell", "d": ["A neuron that stratifies dendrites at two and only two locations."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0487156", "l": "Lymphocyte positive for both CD5 antigen and CD19 antigen", "d": []}, {"i": "SNOMEDCT:117532000", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1267990", "l": "Lymphocyte positive for CD104 antigen", "d": []}, {"i": "SNOMEDCT:117430006", "d": []}]}
{"type": "biolink:Cell", "ic": "88.140761698499901", "identifiers": [{"i": "UMLS:C1708866", "l": "Malignant Chromaffin Cell", "d": []}, {"i": "NCIT:C48560", "l": "Malignant Chromaffin Cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5216206", "l": "Erythrocytes.nucleated|NCnc|Pt|Bld", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4038495", "l": "Cells.aneuploid.S phase population", "d": []}]}
{"type": "biolink:Cell", "ic": "51.595498831515428", "identifiers": [{"i": "CL:0002077", "l": "ecto-epithelial cell", "d": ["An epithelial cell derived from ectoderm."]}]}
{"type": "biolink:Cell", "ic": "92.728541327098611", "identifiers": [{"i": "UMLS:C1513709", "l": "Mucin-Producing Adenocarcinoma Cell", "d": []}, {"i": "NCIT:C36856", "l": "Mucin-Producing Adenocarcinoma Cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5177473", "l": "Plasma cells/100 leukocytes | Dialysis fluid | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0486825", "l": "Germ cells.immature", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1519793", "l": "Unipolar neuron", "d": []}, {"i": "NCIT:C33834", "l": "Unipolar Neuron", "d": ["A conducting cell of the nervous system that has only one process extending from the cell body. It is always a sensory neuron."]}]}
{"type": "biolink:Cell", "ic": "83.552982069901191", "identifiers": [{"i": "CL:0002438", "l": "NK1.1-positive natural killer cell, mouse", "d": ["A mature NK cell that is NK1.1-positive."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0228008", "l": "Primary spermatocyte", "d": []}, {"i": "SNOMEDCT:49904001", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5220572", "l": "Eosinophils|Urine/Urine sed", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0229643", "l": "Eosinophilic metamyelocyte", "d": []}, {"i": "SNOMEDCT:80036001", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5186736", "l": "Leukocytes other | Fetus | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1517638", "l": "KA08", "d": []}, {"i": "NCIT:C20268", "l": "KA08", "d": ["Provider: Karolinska Institute, Stockholm, Sweden. No information from provider. This cell line meets the criteria for the use of human embryonic stem cells by federally funded researchers."]}]}
{"type": "biolink:Cell", "ic": "63.977905698921965", "identifiers": [{"i": "UMLS:C1514302", "l": "Precursor Natural Killer Cell", "d": []}, {"i": "NCIT:C39300", "l": "Precursor Natural Killer Cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1317186", "l": "Cells.CD10+CD25+", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0011114", "l": "segmented neutrophil of bone marrow", "d": ["A segmented neutrophilic cell of the bone marrow reserve pool that expresses CD11b (integrin alpha-M) and high levels of CD16 (low affinity immunoglobulin gamma Fc region receptor III) on its cell surface."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:2000080", "l": "mesenchymal stem cell of abdominal adipose tissue", "d": ["Any mesenchymal stem cell of adipose tissue that is part of an abdomen."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1180270", "l": "Myoepithelial cell of sweat gland", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4518153", "l": "Population of all spermatozoa with acrosome defects in portion of fluid", "d": []}, {"i": "SNOMEDCT:725234006", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1517813", "l": "Mouse Leukoblast", "d": []}, {"i": "NCIT:C22569", "l": "Mouse Leukoblast", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2360583", "l": "Transfuse packed erythrocytes", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157234", "l": "CD10 blasts | Blood | Cell markers", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:4030054", "l": "RXFP1-positive interface island D1-medium spiny neuron", "d": ["A DRD1-expressing medium spiny neuron that is part of dense, RXFP1-positive cell islands throughout the nucleus accumbens, putamen, and near the adjacent septal nuclei."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0000523", "l": "mononuclear cytotrophoblast cell", "d": ["A cell from the inner layer of the trophoblast of the early mammalian embryo that gives rise to the outer surface and villi of the chorion. Mononuclear crytoblasts fuse to give rise to a multinuclear cytotrophoblast."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C4733675", "l": "Autologous PRAME-targeting TCR-modified T Cells MDG1011", "d": []}, {"i": "NCIT:C156136", "l": "Autologous PRAME-targeting TCR-modified T Cells MDG1011", "d": ["Human autologous T-lymphocytes transduced with a retroviral vector encoding a human leukocyte antigen (HLA)-A*02:01-restricted T-cell receptor (TCR) specific for the human tumor-associated antigen (TAA) preferentially expressed antigen in melanoma (PRAME) coupled to the CD3 signaling complex, with potential antineoplastic activity. Upon reintroduction into the patient, the autologous PRAME-targeting TCR-modified T cells MDG1011 target and bind to tumor cells expressing PRAME. This may induce cell death in and halt the growth of PRAME-expressing tumor cells. The TAA PRAME is overexpressed by a variety of cancer cell types."]}]}
{"type": "biolink:Cell", "ic": "41.294590155868569", "identifiers": [{"i": "UMLS:C0014597", "l": "Epithelial Cells", "d": []}, {"i": "NCIT:C12578", "l": "Epithelial Cell", "d": ["Any of the cells of the epithelium, which covers the body and lines its cavities and glands."]}, {"i": "MESH:D004847", "l": "Epithelial Cells", "d": []}, {"i": "SNOMEDCT:4212006", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5666839", "l": "SUPLEXA Therapeutic Cells", "d": []}]}
{"type": "biolink:Cell", "ic": "75.105493098994543", "identifiers": [{"i": "UMLS:C1517919", "l": "Lobular Carcinoma Cell", "d": []}, {"i": "NCIT:C36879", "l": "Lobular Carcinoma Cell", "d": ["A carcinoma cell that originates from the breast lobules. Lobular carcinoma cells are usually smaller than those of ductal breast carcinoma, are less pleomorphic, and have fewer mitotic figures."]}]}
{"type": "biolink:Cell", "ic": "92.728541327098611", "identifiers": [{"i": "CL:4023029", "l": "indirect pathway medium spiny neuron", "d": ["A medium spiny neuron that expresses dopamine type 2 receptors and projects to the external globus pallidus."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5238373", "l": "Allogeneic NKG2DL-targeting CAR-grafted Gamma Delta T Cells", "d": []}, {"i": "NCIT:C167220", "l": "Allogeneic NKG2DL-targeting CAR-grafted Gamma Delta T Cells", "d": ["A preparation of a subset of allogeneic T-lymphocytes that express only gamma chain and delta chain T-cell receptors (TCRs) and that are engineered to express a chimeric antigen receptor (CAR) encoding for human natural-killer group 2, member D receptor protein (NKG2D or KLRK1; natural killer cell activating receptor group 2D), with potential immunomodulating and antineoplastic activities. Upon administration of the NKG2DL-targeting CAR-grafted gamma delta T cells, these cells specifically target and bind to tumor cells expressing NKG2D ligands (NKG2DL). This induces secretion of pro-inflammatory cytokines and results in the lysis of NKG2DL-expressing tumor cells. In addition, these cells target, bind to and kill NKG2DL-expressing tumor-associated endothelial cells in the neovasculature and immunosuppressive cells, such as regulatory T-cells (Tregs) and myeloid-derived suppressor cells (MDSCs) in the tumor microenvironment (TME) that express NKG2D ligands. Gamma/delta T-lymphocytes play a key role in the activation of the immune system and do not require major histocompatibility complex (MHC)-mediated antigen presentation to exert their cytotoxic effect. Ligands for NKG2D, such as MHC class I chain-related protein A (MICA), MICB, and members of the UL16-binding proteins (ULBP)/retinoic acid early transcript 1 (RAET1) family, are overexpressed on infected cells and most cancer cell types, but are not expressed on most normal, healthy cells."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4740204", "l": "Cells.CD4+2H4", "d": []}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "CL:0000253", "l": "eurydendroid cell", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0000849", "l": "crypt olfactory receptor neuron", "d": ["An olfactory receptor cell with short cilia growing in an invagination bordered by microvilli."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5777123", "l": "CD8+ enriched young tumor infiltrating lymphocytes", "d": []}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "UMLS:C1516497", "l": "Chondrocyte-like Cell", "d": []}, {"i": "NCIT:C36982", "l": "Chondrocyte-like Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "83.023198044254755", "identifiers": [{"i": "CL:0000242", "l": "Merkel cell", "d": ["A modified epidermal cell located in the stratum basale. They are found mostly in areas where sensory perception is acute. Merkel cells are closely associated with an expanded terminal bulb of an afferent myelinated nerve fiber."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002008", "l": "CD34-positive, CD38-positive eosinophil progenitor cell", "d": ["A lineage marker-negative, CD34-positive, CD38-positive, IL3r-alpha-positive, IL5r-alpha-positive, and CD45RA-negative eosinophil progenitor cell."]}]}
{"type": "biolink:Cell", "ic": "74.953330836288131", "identifiers": [{"i": "UMLS:C1513987", "l": "Neoplastic Hobnail Cell", "d": []}, {"i": "NCIT:C36758", "l": "Neoplastic Hobnail Cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1180795", "l": "Endothelial cell of lymphatic vessel", "d": []}]}
{"type": "biolink:Cell", "ic": "89.347505587204751", "identifiers": [{"i": "UMLS:C1514002", "l": "Neoplastic Large Ganglioid Astrocyte", "d": []}, {"i": "NCIT:C41469", "l": "Neoplastic Large Ganglioid Astrocyte", "d": []}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "CL:2000092", "l": "hair follicular keratinocyte", "d": ["Any keratinocyte that is part of a hair follicle."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4510903", "l": "Blast cell positive for CD11b antigen", "d": []}, {"i": "SNOMEDCT:724243007", "d": []}]}
{"type": "biolink:Cell", "ic": "90.82444074280258", "identifiers": [{"i": "UMLS:C1710398", "l": "Thymic Epithelial Cell Capable of Differentiating Towards Cortical Cell Type", "d": []}, {"i": "NCIT:C45705", "l": "Thymic Epithelial Cell Capable of Differentiating Towards Cortical Cell Type", "d": ["A reticular epithelial cell generated in the thymus that, in optimal condition, can become a cortex type of thymus cell that mediates positive selection of developing thymocytes."]}]}
{"type": "biolink:Cell", "ic": "89.347505587204751", "identifiers": [{"i": "CL:0009115", "l": "lymph node lymphatic vessel endothelial cell", "d": ["An endothelial cell located in a lymph node lymphatic vessel."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0228074", "l": "Medium sized neuron", "d": []}, {"i": "SNOMEDCT:5802004", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0009112", "l": "centroblast", "d": ["A germinal center B cell found in a lymph node germinal center dark zone."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1180369", "l": "Type V taste bud cell", "d": []}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "CL:0002569", "l": "mesenchymal stem cell of umbilical cord", "d": ["A mesenchymal stem cell of the umbilical cord."]}]}
{"type": "biolink:Cell", "ic": "92.728541327098611", "identifiers": [{"i": "CL:0008037", "l": "gamma motor neuron", "d": ["A lower motor neuron that innervates only intrafusal muscle fibers. Unlike the alpha motor neurons, gamma motor neurons do not directly adjust the lengthening or shortening of muscles but function in adjusting the sensitivity of muscle spindles and in keeping muscle spindles taut, thereby allowing the continued firing of alpha neurons."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1182646", "l": "Pigmented ciliary epithelial cell", "d": []}]}
{"type": "biolink:Cell", "ic": "82.076046914303362", "identifiers": [{"i": "CL:0000467", "l": "adrenocorticotropic hormone secreting cell", "d": ["A peptide hormone secreting cell that produces adrenocorticotropin, or corticotropin."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157477", "l": "CD30 cells | XXX | Cell markers", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4518170", "l": "Population of all immature eosinophils in portion of fluid", "d": []}, {"i": "SNOMEDCT:725440002", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1440055", "l": "Abnormal blood cells.CD5", "d": []}]}
{"type": "biolink:Cell", "ic": "77.061101857006449", "identifiers": [{"i": "UMLS:C1514047", "l": "Neoplastic Neuroendocrine Spindle Cell", "d": []}, {"i": "NCIT:C36935", "l": "Neoplastic Neuroendocrine Spindle Cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2333855", "l": "Parasympathetic preganglionic neuron", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2326743", "l": "Glycinergic amacrine cell of retina", "d": []}]}
{"type": "biolink:Cell", "ic": "90.82444074280258", "identifiers": [{"i": "CL:2000020", "l": "inner cell mass cell", "d": ["Any native cell that is part of a inner cell mass."]}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "CL:0002533", "l": "immature CD16-positive myeloid dendritic cell", "d": ["An immature CD16-positive myeloid dendritic cell is CD80-low, CD86-low, and MHCII-low."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4322735", "l": "CD20+ B lymphocyte", "d": []}]}
{"type": "biolink:Cell", "ic": "87.120474278337809", "identifiers": [{"i": "UMLS:C1879787", "l": "Basal Cell of the Squamous Epithelium", "d": []}, {"i": "NCIT:C61604", "l": "Basal Cell of the Squamous Epithelium", "d": ["A basal cell located in the squamous epithelium."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:1000345", "l": "paneth cell of epithelium of crypt of Lieberkuhn of small intestine", "d": ["A paneth cell that is part of the epithelium of crypt of Lieberkuhn of small intestine."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C3827147", "l": "Adenovector-transduced AP1903-inducible MyD88/CD40-expressing Autologous PSMA-specific Prostate Cancer Vaccine BPX-201", "d": []}, {"i": "NCIT:C106242", "l": "Adenovector-transduced AP1903-inducible MyD88/CD40-expressing Autologous PSMA-specific Prostate Cancer Vaccine BPX-201", "d": ["A genetically-modified, dendritic cell-based (DCs) vaccine in which the autologous cells are transduced with an adenoviral vector expressing the tumor antigen prostate-specific membrane antigen (PSMA) and a fusion protein composed of synthetic ligand inducible adjuvant iMC composed of a drug-inducible costimulatory CD40 receptor (iCD40) and the adaptor protein MyD88, with potential immunomodulating and antineoplastic activities. The iCD40 contains a membrane-localized cytoplasmic CD40 domain fused to the FK506 modified drug-binding protein 12 (FKBP12). Upon intradermal administration of BPX-201, these DCs accumulate in local draining lymph nodes. Twenty-four hours after vaccination, the dimerizing agent AP1903 is administered. AP1903 binds to the drug binding domain, leading to iMC oligomerization and activation of iCD40 and MyD88-mediated signaling in iMC-expressing DCs. This signaling pathway activates the DCs and stimulates a cytotoxic T-lymphocyte (CTL) response against host tumor cells that express PSMA. PSMA, a glycoprotein secreted by prostatic epithelial and ductal cells, is overexpressed in prostate cancer cells and is used as a tumor marker for both diagnosis and treatment evaluation. MyD88 is involved in interleukin 1 receptor (IL1R) and toll-like receptor (TLR) signaling."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1267956", "l": "Lymphocyte positive for CD63 antigen", "d": []}, {"i": "SNOMEDCT:117397007", "d": []}]}
{"type": "biolink:Cell", "ic": "80.869303025598512", "identifiers": [{"i": "CL:0002327", "l": "mammary gland epithelial cell", "d": ["An epithelial cell of the mammary gland."]}]}
{"type": "biolink:Cell", "ic": "51.065714805868986", "identifiers": [{"i": "CL:0000095", "l": "neuron associated cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1717943", "l": "Immunodeficiency markers", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002594", "l": "smooth muscle cell of the umbilical artery", "d": ["A smooth muscle cell of the umbilical artery."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:4033000", "l": "endothelial cell of venule of lymph node", "d": ["A(n) endothelial cell that is part of a(n) venule of lymph node."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5702864", "l": "Anti-CD19 CAR T Cells AT101", "d": []}, {"i": "NCIT:C187300", "l": "Anti-CD19 CAR T Cells AT101", "d": ["A preparation of T-lymphocytes that have been genetically modified to express a chimeric antigen receptor (CAR) targeting the tumor-associated antigen (TAA) CD19 and containing, as of yet undisclosed co-stimulatory signaling domains, with potential immunostimulating and antineoplastic activities. Upon administration, anti-CD19 CAR T cells AT101 recognize and bind to CD19-expressing tumor cells, thereby inducing selective toxicity in CD19-expressing tumor cells. CD19 antigen is a B-cell specific cell surface antigen expressed in all B-cell lineage malignancies."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5168980", "l": "Immature granulocytes | Blood | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5165605", "l": "Germ cells.immature | Semen | Fertility testing", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C0020204", "l": "Hybridomas", "d": []}, {"i": "NCIT:C16700", "l": "Hybridoma", "d": ["A tumor of hybrid cells used in the in vitro production of specific monoclonal antibodies; produced by fusion of an established tissue culture line of lymphocyte tumor cells (e.g., mouse plasmacytoma cells) and specific antibody-producing cells (e.g., splenocytes from specifically immunized mice); fusions are accomplished by use of polyethylene glycol or other methods."]}, {"i": "MESH:D006825", "l": "Hybridomas", "d": []}, {"i": "SNOMEDCT:25326005", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5163710", "l": "Erythrocytes | Body fluid | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0009094", "l": "endothelial cell of hepatic portal vein", "d": ["An endothelial cell that is part of a hepatic portal vein."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:4033035", "l": "giant bipolar cell", "d": ["An ON bipolar cell that has large dendritic and axonal fields."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0004230", "l": "diffuse bistratified amacrine cell", "d": ["A bistratified amacrine cell with a small dendritic field that has post-synaptic terminals in S1 and the border of S1-S2, and termination of a second arbor within the border of S2-S3 and S3."]}]}
{"type": "biolink:Cell", "ic": "86.236661114203869", "identifiers": [{"i": "UMLS:C1514831", "l": "Reliance ES Cell Line", "d": []}, {"i": "NCIT:C20287", "l": "Reliance ES Cell Line", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5179533", "l": "Reticulocytes.mid | Blood | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C3495620", "l": "A11 dopamine cells", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157239", "l": "CD10+CD20+ | White blood cells | Cell markers", "d": []}]}
{"type": "biolink:Cell", "ic": "80.17194633000733", "identifiers": [{"i": "UMLS:C1711299", "l": "Malignant Epithelioid Endothelial Cell", "d": []}, {"i": "NCIT:C53404", "l": "Malignant Epithelioid Endothelial Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C3831440", "l": "Autologous CD19-28z Chimeric Antigen Receptor-expressing T-lymphocytes", "d": []}, {"i": "NCIT:C106247", "l": "Autologous CD19-28z Chimeric Antigen Receptor-expressing T-lymphocytes", "d": ["Genetically modified autologous T-lymphocytes transduced with a replication incompetent retroviral vector expressing a chimeric T cell antigen receptor (CAR) consisting of an anti-CD19 scFv (single chain variable fragment), fused to the extracellular, transmembrane and intracellular signaling domains of the T cell co-stimulatory receptor CD28 and the cytoplasmic signaling domain of the zeta chain of the TCR/CD3 complex (CD3-zeta) (CAR19-28z), with potential antineoplastic activities. Upon intravenous administration, autologous CD19-28z CAR-expressing T-lymphocytes are directed to CD19-expressing tumor cells, which induces selective toxicity in CD19-expressing tumor cells. CD19 antigen is a B-cell specific cell surface antigen expressed in all B-cell lineage malignancies. The CD28 co-stimulatory molecule signaling domain enhances activation and signaling after recognition of CD19. The inclusion of the CD28 signaling domain may increase proliferation of T-cells and antitumor activity compared to the inclusion of the CD3-zeta chain alone."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4082861", "l": "Vascular smooth muscle cell", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C4725932", "l": "Autologous FRa-4SCAR-expressing T-cells 4SCAR-FRa", "d": []}, {"i": "NCIT:C150698", "l": "Autologous FRa-4SCAR-expressing T-cells 4SCAR-FRa", "d": ["A preparation of genetically modified autologous T-cells transduced with a replication incompetent, self-inactivating lentiviral vector expressing a fourth generation chimeric antigen receptor (4SCAR) consisting of an anti-folate receptor alpha (FRa; folate receptor 1; FOLR1) single chain variable fragment (scFv) that is coupled to the costimulatory signaling domains CD28, CD137, CD27 and the zeta chain of the T-cell receptor (CD3zeta; CD3z), and is fused with the suicide gene inducible caspase 9 (iCasp9), with potential immunostimulating and antineoplastic activities. Upon administration, autologous FRa-4SCAR-expressing T-cells 4SCAR-FRa are directed to and induce selective toxicity in FRa-expressing tumor cells. iCasp9 consists of a human FK506 drug-binding domain with an F36V mutation (FKBP12-F36V) linked to human caspase 9. If the administered T-cells lead to unacceptable side effects, the chemical homodimerizer AP1903 can be administered. AP1903 binds to the drug binding FKBP12-F36V domain and induces activation of caspase 9, which results in the apoptosis of the administered T-cells and enhances safety of this agent. FRa is overexpressed in various tumor cell types, and is associated with increased leukemic cell proliferation and aggressiveness. CD28, CD137 and CD27, T-cell surface-associated co-stimulatory molecules, are required for full T-cell activation and enhance both proliferation of T-cells and antitumor activity."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5700380", "l": "Autologous TIL LN-144", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1440334", "l": "Cells.CD58", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002460", "l": "CD8alpha-negative thymic conventional dendritic cell", "d": ["A conventional thymic dendritic cell that is CD8alpha-negative."]}]}
{"type": "biolink:Cell", "ic": "89.347505587204751", "identifiers": [{"i": "CL:0000352", "l": "epiblast cell", "d": ["A cell of the outer layer of a blastula that gives rise to the ectoderm after gastrulation."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1879680", "l": "remestemcel-l", "d": []}, {"i": "MESH:C000711674", "l": "remestemcel-l", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C3496153", "l": "A9 dopamine cells", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1180368", "l": "Type III taste bud cell", "d": []}]}
{"type": "biolink:Cell", "ic": "92.728541327098611", "identifiers": [{"i": "CL:0000889", "l": "myeloid suppressor cell", "d": ["An immature myeloid leukocyte of heterogeneous phenotype found particularly in cancer and sepsis patients that is capable of suppressing activity of T cells in ex vivo assays. This cell type is CD45-positive, CD11b-positive."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157333", "l": "CD16C+CD56+ cells | Blood | Cell markers", "d": []}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "UMLS:C5392114", "l": "T Follicular Helper Cells", "d": []}, {"i": "NCIT:C176755", "l": "Follicular Helper T Cell", "d": ["A subtype of antigen-experienced CD4+ T cells that are primarily found within B cell follicles near the periphery of secondary lymphoid organs and are involved in the formation and maintenance of germinal centers. These cells express CXCR5 and CD40L and secrete IL-21 and IL-4."]}, {"i": "MESH:D000084522", "l": "T Follicular Helper Cells", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1513747", "l": "Multinucleated Reed-Sternberg Cell", "d": []}, {"i": "NCIT:C36813", "l": "Multinucleated Reed-Sternberg Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0000436", "l": "vaginal lubricant secreting cell", "d": []}]}
{"type": "biolink:Cell", "ic": "83.023198044254755", "identifiers": [{"i": "CL:0002087", "l": "nongranular leukocyte", "d": ["A leukocyte that lacks granules."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C3642265", "l": "Autologous CD19CAR-CD28-CD3zeta-EGFRt-expressing Tcm-enriched T Cells", "d": []}, {"i": "NCIT:C105614", "l": "Autologous CD19CAR-CD28-CD3zeta-EGFRt-expressing Tcm-enriched T Cells", "d": ["A preparation of genetically modified autologous central memory (Tcm) enriched T-cells transduced with a replication incompetent lentiviral vector expressing a chimeric antigen receptor (CAR), containing a CD28 signaling domain fused to both CD3 zeta, which targets the CD19 antigen, and a truncated form of the human epidermal growth factor receptor (EGFRt), with potential immunostimulating and antineoplastic activities. Upon intravenous administration, autologous CD19CAR-CD28-CD3zeta-EGFRt-expressing Tcm-enriched T cells are directed to CD19-expressing tumor cells, thereby inducing a selective toxicity in CD19-expressing tumor cells. CD19 antigen is a B-cell specific cell surface antigen expressed in all B-cell lineage malignancies.  Devoid of both ligand binding domains and tyrosine kinase activity, EGFRt both facilitates in vivo detection of the administered T-cells and can promote elimination of those cells upon a cetuximab-induced antibody dependent cellular cytotoxicity response. The costimulatory signaling domain enhances proliferation of T cells and antitumor activity."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0004241", "l": "WF2 amacrine cell", "d": ["An amacrine cell with a wide dendritic field, dendrites in S2, and post-synaptic terminals in S1."]}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "CL:0002378", "l": "immature Vgamma2-positive fetal thymocyte", "d": ["A double negative thymocyte that has a T cell receptor consisting of a gamma chain containing a Vgamma2 segment, and a delta chain. This cell type is CD4-negative, CD8-negative and CD24-positive and is found in the fetal thymus."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157386", "l": "CD20+FMC7+ cells | Tissue and Smears | Cell markers", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157446", "l": "CD3+CD5- cells | Cerebral spinal fluid | Cell markers", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1440143", "l": "Blasts.CD19", "d": []}]}
{"type": "biolink:Cell", "ic": "68.368095522595297", "identifiers": [{"i": "CL:0000818", "l": "transitional stage B cell", "d": ["An immature B cell of an intermediate stage between the pre-B cell stage and the mature naive stage with the phenotype surface IgM-positive and CD19-positive, and are subject to the process of B cell selection. A transitional B cell migrates from the bone marrow into the peripheral circulation, and then to the spleen."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157651", "l": "CD7+CD3- | White blood cells | Cell markers", "d": []}]}
{"type": "biolink:Cell", "ic": "85.457082654197222", "identifiers": [{"i": "UMLS:C1513170", "l": "Metaplastic Cell", "d": []}, {"i": "NCIT:C36786", "l": "Metaplastic Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "67.681872163386743", "identifiers": [{"i": "UMLS:C1513940", "l": "Neoplastic Clear Cell", "d": []}, {"i": "NCIT:C36757", "l": "Neoplastic Clear Cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4246840", "l": "Trunk neural crest cell", "d": []}]}
{"type": "biolink:Cell", "ic": "74.804588241401973", "identifiers": [{"i": "UMLS:C1510733", "l": "Abnormal Neutrophil", "d": []}, {"i": "NCIT:C37029", "l": "Abnormal Neutrophil", "d": []}]}
{"type": "biolink:Cell", "ic": "87.120474278337809", "identifiers": [{"i": "CL:0000162", "l": "parietal cell", "d": ["A large, oval stomach epithelial cell with a central nucleus; source of gastric acid. Secretes HCl."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1179517", "l": "Acinar cell of pancreas", "d": []}, {"i": "NCIT:C174117", "l": "Pancreatic Acinar Cell", "d": ["A cell which secretes digestive enzymes via the pancreatic duct into the duodenum to assist in digestion."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5549357", "l": "Normoblasts.total", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0001041", "l": "CD8-positive, CXCR3-positive, alpha-beta regulatory T cell", "d": ["A CD8-positive alpha-beta-positive T cell with the phenotype CXCR3-positive and having suppressor function. They are capable of producing IL-10, suppressing proliferation, and suppressing IFN-gamma production."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0546502", "l": "P.B. megakaryocyte", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0000690", "l": "R2 photoreceptor cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1268000", "l": "Lymphocyte positive for CD122 antigen", "d": []}, {"i": "SNOMEDCT:117440009", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1513174", "l": "Metaplastic Hurthle Cell", "d": []}, {"i": "NCIT:C36875", "l": "Metaplastic Hurthle Cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1317736", "l": "Progressive spermatozoa", "d": []}, {"i": "SNOMEDCT:726586008", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5427570", "l": "Cones.left", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5179530", "l": "Reticulocytes.mature | Blood | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "ic": "75.923665061460838", "identifiers": [{"i": "UMLS:C1514170", "l": "Pleomorphic Cell", "d": []}, {"i": "NCIT:C37111", "l": "Pleomorphic Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002521", "l": "subcutaneous fat cell", "d": ["A fat cell that is part of subcutaneous adipose tissue."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1440246", "l": "Cells.CD11b+CD56+", "d": []}]}
{"type": "biolink:Cell", "ic": "80.511444690059548", "identifiers": [{"i": "UMLS:C1518307", "l": "Neutrophil with Cytoplasmic Hypogranularity", "d": []}, {"i": "NCIT:C37174", "l": "Neutrophil with Cytoplasmic Hypogranularity", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2327855", "l": "Type ECL enteroendocrine cell", "d": []}]}
{"type": "biolink:Cell", "ic": "89.347505587204751", "identifiers": [{"i": "CL:0000175", "l": "luteal cell", "d": ["A progesterone secreting cell in the corpus luteum. The large luteal cells develop from the granulosa cells. The small luteal cells develop from the theca cells."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C4086505", "l": "ICT-121 Dendritic Cell Vaccine", "d": []}, {"i": "NCIT:C124652", "l": "ICT-121 Dendritic Cell Vaccine", "d": ["A cell-based cancer vaccine composed of autologous dendritic cells (DCs) pulsed with purified peptides derived from the tumor-associated antigen (TAA) CD133, with potential immunostimulatory and antineoplastic activities. Upon leukapheresis, monocytes are differentiated into DCs and are mixed with the CD133 peptides. Upon intradermal re-administration of the ICT-121 DC vaccine, the DCs present the CD133 peptides to the immune system, which stimulates the immune system to induce a specific cytotoxic T-lymphocyte (CTL) response against CD133-expressing tumor cells and leads to tumor cell lysis. CD133 is overexpressed on various types of cancer cells; its overexpression is correlated with increased resistance to chemotherapy."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1267885", "l": "Lymphoblast positive for CD19 antigen", "d": []}, {"i": "SNOMEDCT:117562006", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5171750", "l": "Lymphocytes+Monocytes | Blood | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "CL:0000935", "l": "CD4-negative, CD8-negative, alpha-beta intraepithelial T cell", "d": ["A CD4-negative, CD8-negative, alpha-beta intraepithelial T cell that is found in the columnar epithelium of the gastrointestinal tract."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157598", "l": "CD5+CD20+ cells | Blood | Cell markers", "d": []}]}
{"type": "biolink:Cell", "ic": "88.140761698499901", "identifiers": [{"i": "CL:0002173", "l": "extraglomerular mesangial cell", "d": ["A cell that is a specialized type of pericyte providing structural support for the capillary loops of kidney. A flat, elongated cell with extensive fine cytoplasmic processes found outside the kidney glomerulus near the macula densa and bound laterally by afferent and efferent arterioles. Being phagocytic, this cell participates in the continuous turnover of the basal lamina by removing its outer portion containing residues of filtration, while the lamina is renewed on its inner surface by the endothelial cells."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5380994", "l": "Cells.CD8.HLA-B8 CMV specific.CMV antigen stimulated gamma interferon producing", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C0228089", "l": "Protoplasmic astrocyte", "d": []}, {"i": "NCIT:C33415", "l": "Protoplasmic Astrocyte", "d": []}, {"i": "SNOMEDCT:4328003", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5212878", "l": "Neutrophils.CD64", "d": []}]}
{"type": "biolink:Cell", "ic": "58.709983342611608", "identifiers": [{"i": "CL:0000153", "l": "glycosaminoglycan secreting cell", "d": ["A cell that secretes glycosaminoglycans."]}]}
{"type": "biolink:Cell", "ic": "58.594648570918388", "identifiers": [{"i": "UMLS:C1706683", "l": "Abnormal Germ Cell", "d": []}, {"i": "NCIT:C54103", "l": "Abnormal Germ Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002610", "l": "raphe nuclei neuron", "d": ["A neuron of the raphe nuclei."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2326168", "l": "Oligodendroblast", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0600432", "l": "K562 Cells", "d": []}, {"i": "MESH:D020014", "l": "K562 Cells", "d": []}]}
{"type": "biolink:Cell", "ic": "65.447681560237257", "identifiers": [{"i": "CL:0002420", "l": "immature T cell", "d": ["A T cell that has not completed T cell selection."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1440309", "l": "Cells.CD42b", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5175152", "l": "Nucleated cells | Peritoneal fluid | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2919236", "l": "Colony-forming unit of granulocytic-monocytic lineage (cell)", "d": []}, {"i": "SNOMEDCT:445259001", "d": []}]}
{"type": "biolink:Cell", "ic": "59.234383192480088", "identifiers": [{"i": "CL:0000300", "l": "gamete", "d": ["A mature sexual reproductive cell having a single set of unpaired chromosomes."]}]}
{"type": "biolink:Cell", "ic": "83.552982069901191", "identifiers": [{"i": "UMLS:C1514175", "l": "Pleomorphic Medium-Sized to Large T-Lymphocyte", "d": []}, {"i": "NCIT:C39602", "l": "Pleomorphic Medium-Sized to Large T-Lymphocyte", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:1000333", "l": "serous cell of epithelium of lobular bronchiole", "d": ["A serous secreting cell that is part of the epithelium of bronchiole."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0747205", "l": "PANCYTOSIS", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:4030000", "l": "choroidal melanocyte", "d": ["A melanocyte located in the vascular uvea and involved in photoprotection, regulation of oxidative damage and immune responses."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5177783", "l": "Polymorphonuclear cells | Synovial fluid | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1180090", "l": "Non-nucleated lens fiber", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5560996", "l": "Allogeneic cultured keratinocytes and fibroblasts in bovine collagen", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5163538", "l": "Epithelial cells | Blood | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0682547", "l": "Eosinophilic cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1115673", "l": "Lymphocytes.lambda", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1708978", "l": "Melanoma Tumor-Reactive Autologous Tumor Infiltrating Lymphocyte", "d": []}, {"i": "NCIT:C48814", "l": "Melanoma Tumor-Reactive Autologous Tumor Infiltrating Lymphocyte", "d": ["Tumor infiltrating lymphocytes (TIL) harvested directly from infiltrate of a patient's melanoma and cultured with interleukin-2 to expand the TIL cell population. Tumor infiltrating lymphocytes have specific activity against the melanoma from which they are derived. Introducing these melanoma tumor-reactive autologous tumor infiltrating lymphocytes back into the same patient may enhance a cytotoxic T-cell-mediated immune response against the melanoma cancer cells."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C0949753", "l": "Nitrergic Neurons", "d": []}, {"i": "NCIT:C12647", "l": "Nitrergic Neuron", "d": ["A nerve cell that uses nitric oxide as its neurotransmitter."]}, {"i": "MESH:D026602", "l": "Nitrergic Neurons", "d": []}]}
{"type": "biolink:Cell", "ic": "86.236661114203869", "identifiers": [{"i": "CL:0004250", "l": "bistratified retinal amacrine cell", "d": ["An amicrine that stratifies dendrites at two and only two locations."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157372", "l": "CD2 cells | Tissue and Smears | Cell markers", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2332996", "l": "Thrombocytopoietic cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5454842", "l": "Cells.Not specified", "d": []}]}
{"type": "biolink:Cell", "ic": "61.11520282797931", "identifiers": [{"i": "CL:0000408", "l": "male gamete", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1180383", "l": "Specialized cardiac myocyte", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5167386", "l": "Histiocytes | Cerebral spinal fluid | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002444", "l": "Ly49H-positive natural killer cell, mouse", "d": ["A NK1.1-positive T cell that is Ly49H-positive."]}]}
{"type": "biolink:Cell", "ic": "71.975435936396124", "identifiers": [{"i": "CL:1000612", "l": "kidney corpuscule cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157653", "l": "CD71 cells | Blood | Cell markers", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5571778", "l": "Cells.CD19+CD22+", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157421", "l": "CD3 blasts | Bone marrow | Cell markers", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5163557", "l": "Epithelial cells.squamous | Urine | Urinalysis", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2324975", "l": "Enterocyte of epithelium proper of large intestine", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2936239", "l": "HEK293 Cells", "d": []}, {"i": "MESH:D057809", "l": "HEK293 Cells", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002333", "l": "neural crest derived fat cell", "d": ["A fat cell derived from a neural crest cell."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:4023074", "l": "mammillary body neuron", "d": ["A neuron that has its soma located in the mammillary body."]}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "UMLS:C1523993", "l": "Leukocyte - Monocyte - Macrophage (MMHCC)", "d": []}, {"i": "NCIT:C22587", "l": "Mouse Macrophage", "d": []}]}
{"type": "biolink:Cell", "ic": "69.78964318410506", "identifiers": [{"i": "CL:0000955", "l": "pre-B-II cell", "d": ["A pre-B-II cell is a precursor B cell that expresses immunoglobulin mu heavy chain (IgHmu+), and lack expression of CD34, TdT, immunoglobulin kappa light chain and immunoglobulin lambda light chain."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:1000290", "l": "myocyte of middle internodal tract", "d": ["A muscle cell that is part of the middle internodal tract."]}]}
{"type": "biolink:Cell", "ic": "92.728541327098611", "identifiers": [{"i": "CL:0002105", "l": "CD38-positive IgG memory B cell", "d": ["A CD38-positive IgG memory B cell is a class switched memory B cell that expresses IgG on the cell surface with the phenotype CD38-positive and IgG-positive."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002055", "l": "CD38-negative immature B cell", "d": ["An immature B cell that is CD38-negative, CD10-low, CD21-low, and CD22-high."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5174627", "l": "Neutrophils | Vitreous fluid | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5216198", "l": "Cells|NCnc|Pt|Body fld", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1512308", "l": "HL-60/MX1", "d": []}, {"i": "NCIT:C20230", "l": "HL-60/MX1", "d": ["HL-60/MX1 is a mitoxantrone resistant derivative of the HL-60 cell line. The cells were selected and subcloned in 1987 for resistance to 39 nM mitoxantrone, an anthracenedione antitumor agent. Subsequent exposure of the HL-60/MX1 cells to higher concentrations of mitoxantrone led to the emergence of cells capable of growth at 190 nM. HL-60/MX1 cells are cross resistant to etoposide, teniposide, bisantrene, actinomycin, 4'-(9-acridinylamino)methane-sulfon-m-anisidide, and the anthracyclines daunorubicin and doxorubicin but retain sensitivity to the Vinca alkaloids vincristine and vinblastine, melphalan, mitomycin C and cisplatin."]}]}
{"type": "biolink:Cell", "ic": "76.857431420584163", "identifiers": [{"i": "UMLS:C1709898", "l": "Renal Pelvis Urothelial Cell", "d": []}, {"i": "NCIT:C54557", "l": "Renal Pelvis Urothelial Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "92.728541327098611", "identifiers": [{"i": "UMLS:C1708709", "l": "Lipoblast-Like Malignant Transitional Cell", "d": []}, {"i": "NCIT:C54562", "l": "Lipoblast-Like Malignant Transitional Cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2329382", "l": "Brush cell of epithelium proper of large intestine", "d": []}]}
{"type": "biolink:Cell", "ic": "89.347505587204751", "identifiers": [{"i": "CL:0003020", "l": "retinal ganglion cell C outer", "d": ["A retinal ganglion cell C that has post-synaptic terminals in S2."]}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "UMLS:C1513936", "l": "Neoplastic Cerebriform T-Prolymphocyte", "d": []}, {"i": "NCIT:C39572", "l": "Neoplastic Cerebriform T-Prolymphocyte", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:1000305", "l": "fibroblast of connective tissue of glandular part of prostate", "d": ["A fibroblast that is part of the connective tissue of glandular part of prostate."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2708698", "l": "Cells.HLA-B27", "d": []}]}
{"type": "biolink:Cell", "ic": "78.96520244130248", "identifiers": [{"i": "CL:0000578", "l": "experimentally modified cell in vitro", "d": ["A cell in vitro that has undergone physical changes as a consequence of a deliberate and specific experimental procedure."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1440285", "l": "Cells.CD3+CD69+", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157449", "l": "CD3+CD56+ cells | Body fluid | Cell markers", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5776766", "l": "RBC^Father", "d": []}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "CL:0011022", "l": "fibroblast of skin of back", "d": ["A fibroblast that is part of skin of back."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5237046", "l": "Anti-TRBC1-CAR-CD3zeta-4-1BB-RQR8-expressing Autologous T-lymphocyte Cells AUTO4", "d": []}, {"i": "NCIT:C165274", "l": "Anti-TRBC1-CAR-CD3zeta-4-1BB-RQR8-expressing Autologous T-lymphocyte Cells AUTO4", "d": ["Autologous human T-lymphocytes that are genetically engineered to express a chimeric antigen receptor (CAR) containing an anti-T-cell receptor beta constant 1 (TRBC1; T-cell receptor beta-1 chain C region) single chain variable fragment (scFv) and the co-stimulatory domain 4-1BB (CD137) coupled to the zeta chain of the TCR/CD3 complex (CD3-zeta), with potential immunostimulating and antineoplastic activities. Upon administration, anti-TRBC1-CAR-CD3zeta-4-1BB-RQR8-expressing autologous T-lymphocyte cells AUTO4 targets and binds to the TRBC1 expressed on tumor cell surfaces. Subsequently, TRBC1-expressing tumor cells are lysed. In addition, AUTO4 carries the universal RQR8 safety \"off\" switch, which allows selective removal of the T-cells through both complement-dependent cytotoxicity (CDC) and antibody-dependent cellular cytotoxicity (ADCC) following administration of rituximab if unacceptable side-effects occur."]}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "CL:0000533", "l": "primary motor neuron (sensu Teleostei)", "d": ["A primary neuron (sensu Teleostei) that has a motor function."]}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "UMLS:C1518997", "l": "Peripheral Blood Lymphocyte", "d": []}, {"i": "NCIT:C12938", "l": "Peripheral Blood Lymphocyte", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2329360", "l": "Brush cell of epithelium of terminal bronchiole", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0229542", "l": "Pituitary amphophil cell", "d": []}, {"i": "SNOMEDCT:19992001", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0000027", "l": "smooth muscle cell neural crest derived", "d": ["A smooth muscle cell derived from the neural crest."]}]}
{"type": "biolink:Cell", "ic": "75.923665061460838", "identifiers": [{"i": "UMLS:C1707339", "l": "Neoplastic Centrocyte", "d": []}, {"i": "NCIT:C36743", "l": "Neoplastic Centrocyte", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2339635", "l": "Enterocyte of epithelium of crypt of Lieberkuhn of small intestine", "d": []}]}
{"type": "biolink:Cell", "ic": "71.786315444102826", "identifiers": [{"i": "UMLS:C1709215", "l": "Neural Crest-Derived Cell", "d": []}, {"i": "NCIT:C48431", "l": "Neural Crest-Derived Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0000987", "l": "IgA plasma cell", "d": ["A fully differentiated plasma cell that secretes IgA."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:2000070", "l": "optic choroid fibroblast", "d": ["Any fibroblast that is part of a optic choroid."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157519", "l": "CD3-CD16+CD56+ (Natural killer) cells | Blood | Cell markers", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5667000", "l": "Autologous CD34+-enriched HSPCs Transduced with LV Vector Carrying TCIRG1 Gene RP-L401", "d": []}, {"i": "NCIT:C185445", "l": "Autologous CD34+-enriched HSPCs Transduced with LV Vector Carrying TCIRG1 Gene RP-L401", "d": ["A preparation of autologous CD34+-enriched hematopoietic stem and progenitor cells (HSPCs) from mobilized peripheral blood of patients with infantile malignant osteopetrosis (IMO) that are transduced ex vivo with a lentiviral (LV) vector carrying the T cell immune regulator 1 (TCIRG1) gene, with potential to restore TCIRG1 expression and function. Upon re-infusion of autologous CD34+-enriched HSPCs transduced with LV vector carrying TCIRG1 gene RP-L401 back into the patient, these cells express functional TCIRG1 gene. Mutations in the TCIRG1 gene, found in some patients with IMO, lead to functional impairment of the proton pump of the osteoclast."]}]}
{"type": "biolink:Cell", "ic": "92.728541327098611", "identifiers": [{"i": "UMLS:C0229614", "l": "Prolymphocyte (cell)", "d": []}, {"i": "NCIT:C13119", "l": "Prolymphocyte", "d": ["A medium-sized round lymphocyte of B or T-cell lineage with prominent nucleoli.  It is an intermediate cell between the lymphoblast and the small, mature lymphocyte."]}, {"i": "SNOMEDCT:19394005", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1513175", "l": "Metaplastic Myoepithelial Cell", "d": []}, {"i": "NCIT:C37168", "l": "Metaplastic Myoepithelial Cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4304494", "l": "Population of all stomatocytes in portion of fluid", "d": []}, {"i": "SNOMEDCT:719694005", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2322638", "l": "Set of cholinergic cells of globus pallidus [Ch3]", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1517881", "l": "Light Cell", "d": []}, {"i": "NCIT:C13148", "l": "Light Cell", "d": ["A cell located in the collecting tube of the nephron.."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002447", "l": "CD94-negative natural killer cell, mouse", "d": ["A NK1.1-positive T cell that is CD94-negative."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1267959", "l": "Lymphocyte positive for CD66B antigen", "d": []}, {"i": "SNOMEDCT:117400003", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5197771", "l": "Cerebellar Golgi Cells", "d": []}, {"i": "MESH:D000080906", "l": "Cerebellar Golgi Cells", "d": []}]}
{"type": "biolink:Cell", "ic": "90.82444074280258", "identifiers": [{"i": "CL:0000577", "l": "type EC enteroendocrine cell", "d": ["A subtype of enteroendocrine cells found in the gastrointestinal mucosa, particularly in the glands of pyloric antrum; duodenum; and ileum. These cell type secretes serotonin and some neurotransmitters including enkephalins and substance P. Their secretory granules stain readily with silver (argentaffin stain)."]}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "UMLS:C1517214", "l": "Flower-Like T-Lymphocyte", "d": []}, {"i": "NCIT:C39682", "l": "Flower-Like T-Lymphocyte", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5454450", "l": "Leukocytes | Lower respiratory specimen | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0224523", "l": "Synovial fluid mononuclear cell", "d": []}, {"i": "SNOMEDCT:77589000", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2326796", "l": "Chromophil cell of pars distalis of adenohypophysis", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4697019", "l": "Cells.CD25+CD45RO+CD127Low+", "d": []}]}
{"type": "biolink:Cell", "ic": "89.347505587204751", "identifiers": [{"i": "CL:0001074", "l": "CD34-positive, CD56-positive, CD117-positive common innate lymphoid precursor, human", "d": ["An innate lymphoid cell precursor in the human with the phenotype CD34-positive, CD56-positive, CD117-positive.Thie cell type may include precusors to NK cells and ILC3 cells."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5154479", "l": "Basophils | Nose | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0333719", "l": "Anuclear squame", "d": []}, {"i": "SNOMEDCT:85313000", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5554748", "l": "Allogeneic Anti-CD70-CAR T-cells ALLO-316", "d": []}, {"i": "NCIT:C177917", "l": "Allogeneic Anti-CD70-CAR T-cells ALLO-316", "d": ["An off-the-shelf (OTS) preparation of human allogeneic T-lymphocytes obtained from healthy donors that are engineered to express a chimeric antigen receptor (CAR) specific for the tumor-associated antigen (TAA) human cluster of differentiation 70 (CD70) and gene-edited with transcription activator-like effector nuclease (TALEN) to inactivate the endogenous T-cell receptor alpha constant (TRAC) and CD52 loci, with potential immunostimulating and antineoplastic activities. Upon introduction into the patient, the allogeneic anti-CD70-CAR T-cells ALLO-316 recognize and bind to CD70-expressing tumor cells. This may result in a specific cytotoxic T-lymphocyte (CTL)-mediated killing of CD70-positive tumor cells. CD70, a type II transmembrane glycoprotein and member of the tumor necrosis factor (TNF) family, is found on the surfaces of various types of cancer cells. Deletion of the CD52 gene makes the modified donor T-cells resistant to anti-CD52 monoclonal antibodies, which can be used during lymphodepletion. The deletion of the TRAC gene abrogates the potential induction of graft-versus-host disease (GvHD) by the donor T-cells."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0312865", "l": "Sensitized red cell", "d": []}, {"i": "SNOMEDCT:57722009", "d": []}]}
{"type": "biolink:Cell", "ic": "84.75972595860604", "identifiers": [{"i": "CL:0002395", "l": "Gr1-high classical monocyte", "d": ["A resident monocyte that is Gr-1 high, CD43-negative, CX3CR1-negative, CD115-positive, and B220-negative."]}]}
{"type": "biolink:Cell", "ic": "83.023198044254755", "identifiers": [{"i": "UMLS:C1706982", "l": "Granulocyte-Monocyte Progenitor Cell", "d": []}, {"i": "NCIT:C42766", "l": "Granulocyte-Monocyte Progenitor Cell", "d": ["A primitive, undifferentiated blood cell which can undergo division and give rise to white blood cells in the neutrophil, eosinophil, basophil or monocyte lines."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0312864", "l": "Sensitized cell", "d": []}, {"i": "SNOMEDCT:52976009", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5170938", "l": "Leukocytes | Semen | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1280517", "l": "Entire exocervical epithelial cell", "d": []}, {"i": "SNOMEDCT:255268008", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1184137", "l": "Myoepithelial cell of main lactiferous duct", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5666998", "l": "Liver Cancer Neoantigens-sensitized Autoimmune Cells IPM001", "d": []}, {"i": "NCIT:C185431", "l": "Liver Cancer Neoantigens-sensitized Autoimmune Cells IPM001", "d": ["A preparation of autoimmune cells that have been sensitized to liver cancer neoantigens, with potential immunostimulating and antineoplastic activities, Upon administration of the liver cancer neoantigens-sensitized autoimmune cells IPM001, these cells may eradicate the liver cancer cells."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157240", "l": "CD10+CD20+ cells | Blood | Cell markers", "d": []}]}
{"type": "biolink:Cell", "ic": "84.75972595860604", "identifiers": [{"i": "CL:0002052", "l": "fraction D precursor B cell", "d": ["A pre-B cell that is pre-BCR-negative, and the kappa- and lambda- light immunoglobulin light chain-negative, CD43-low, and is BP-1-positive, CD45R-positive and CD25-positive. This cell type is also described as being AA4-positive, IgM-negative, CD19-positive, CD43-low/negative, and HSA-positive."]}]}
{"type": "biolink:Cell", "ic": "88.140761698499901", "identifiers": [{"i": "UMLS:C0025166", "l": "Megakaryocytes", "d": []}, {"i": "NCIT:C12553", "l": "Megakaryocyte", "d": ["Very large bone marrow cells which release mature blood platelets."]}, {"i": "MESH:D008533", "l": "Megakaryocytes", "d": []}, {"i": "SNOMEDCT:23592000", "d": []}]}
{"type": "biolink:Cell", "ic": "90.82444074280258", "identifiers": [{"i": "UMLS:C1514274", "l": "Postgerminal Center Memory B-Lymphocyte", "d": []}, {"i": "NCIT:C38339", "l": "Postgerminal Center Memory B-Lymphocyte", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1511434", "l": "CEA RNA-pulsed Autologous Human Cultured Dendritic Cells", "d": []}, {"i": "NCIT:C2710", "l": "CEA RNA-pulsed Autologous Human Cultured Dendritic Cells", "d": ["Autologous human dendritic cells pulsed with RNA encoding the carcinoembryonic antigen (CEA) are being studied for possible use in the treatment of cancer expressing CEA."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0009103", "l": "lymph node marginal reticular cell", "d": ["A fibroblastic reticular cell found in the lymph node subcapsular sinus."]}]}
{"type": "biolink:Cell", "ic": "74.659114980698789", "identifiers": [{"i": "CL:0000609", "l": "vestibular hair cell", "d": ["A mechanoreceptor located in the acoustic maculae and the semicircular canals that mediates the sense of balance, movement, and head position. The vestibular hair cells are connected to accessory structures in such a way that movements of the head displace their stereocilia. This influences the membrane potential of the cells which relay information about movements via the vestibular part of the vestibulocochlear nerve to the brain stem."]}]}
{"type": "biolink:Cell", "ic": "73.476395680690302", "identifiers": [{"i": "CL:0000170", "l": "glucagon secreting cell", "d": ["A cell that secretes glucagon."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C3488038", "l": "human breast tumor cell", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1518750", "l": "Mouse Ovarian Follicular Cell", "d": []}, {"i": "NCIT:C22661", "l": "Mouse Ovarian Follicular Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "CL:0000966", "l": "Bm4 B cell", "d": ["A germinal center B cell that has the phenotype CD77-negative, IgD-negative, and CD38-positive. These cells have undergone somatic mutation of the B cell receptor."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4277739", "l": "Tenocytes", "d": []}, {"i": "MESH:D000070916", "l": "Tenocytes", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:1000291", "l": "myocyte of posterior internodal tract", "d": ["A muscle cell that is part of the posterior internodal tract."]}]}
{"type": "biolink:Cell", "ic": "52.957607393616669", "identifiers": [{"i": "UMLS:C1517548", "l": "Glandular cell", "d": []}, {"i": "NCIT:C33923", "l": "Glandular Cell", "d": ["An epithelial cell which may release secretions to a free epithelial surface (exocrine) or to the circulatory system (endocrine)."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:1001100", "l": "kidney efferent arteriole smooth muscle cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5170953", "l": "Leukocytes other | Fetus | Blood | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "CL:1000090", "l": "pronephric nephron tubule epithelial cell", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C4055479", "l": "Allogeneic CD3- CD19- Selected Natural Killer Cells", "d": []}, {"i": "NCIT:C121445", "l": "Allogeneic CD3- CD19- Selected Natural Killer Cells", "d": ["Human leukocyte antigen (HLA)-haploidentical donor-derived natural killer (NK) cells that are activated with the cytokine interleukin-15 (IL-15), with immunomodulating and antineoplastic activities. Upon leukapheresis, the HLA-haploidentical donor peripheral blood mononuclear cells (PBMCs) are treated to remove T-lymphocytes (CD3+) and B-lymphocytes (CD19+) cells. In turn, NK cells are expanded and activated with IL-15. Upon infusion of the allogeneic CD3- CD19- selected NK cells, these cells recognize and bind to tumor cells, and secrete perforins, granzymes, and cytokines, which results in cancer cell lysis."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2338580", "l": "Otic ganglion neuron", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0009012", "l": "transit amplifying cell of small intestine", "d": ["A rapidly proliferating population of cells that differentiate from stem cells of the intestinal crypt of the small intestine. Stem cells located in the crypts of Lieberkühn give rise to proliferating progenitor or transit amplifying cells that differentiate into the four major epithelial cell types. These include columnar absorptive cells or enterocytes, mucous secreting goblet cells, enteroendocrine cells and paneth cells."]}]}
{"type": "biolink:Cell", "ic": "77.061101857006449", "identifiers": [{"i": "UMLS:C0014792", "l": "Erythrocytes", "d": []}, {"i": "NCIT:C12521", "l": "Erythrocyte", "d": ["Cell specialized for oxygen transport, having a high concentration of hemoglobin in the cytoplasm and little else; biconcave, anucleate discs, 7nm diameter in mammals."]}, {"i": "MESH:D004912", "l": "Erythrocytes", "d": []}, {"i": "SNOMEDCT:41898006", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:4030008", "l": "pronephric podocyte", "d": ["A specialized epithelial cell that contains \"feet\" that interdigitate with the \"feet\" of other glomerular epithelial cells in the pronephros."]}]}
{"type": "biolink:Cell", "ic": "92.728541327098611", "identifiers": [{"i": "CL:0000645", "l": "pituicyte", "d": ["A glial cell of astrocytic lineage with long processes running parallel to adjacent axons in the proximal infundibulum of the neurohypophysis. These processes form a three-dimensional network among the axons of the hypothalamic neurosecretory cells and are connected by gap junctions which provide for their metabolic coupling. This cell type constitutes most of the nonexcitable tissue in the neurohypophsis; function may include possibly acting as an intermediate in the modulation of oxytocin and vasopressin release. This cell type is highly variable in size and shape and commonly contain lipid droplets and deposits of lipochrome pigment."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5170472", "l": "Large unstained cells | Blood | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5167388", "l": "Histiocytes | Urine sediment | Urinalysis", "d": []}]}
{"type": "biolink:Cell", "ic": "92.728541327098611", "identifiers": [{"i": "UMLS:C1517543", "l": "Giant Cell with Myoblastic Differentiation", "d": []}, {"i": "NCIT:C36828", "l": "Giant Cell with Myoblastic Differentiation", "d": []}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "CL:0008017", "l": "adult skeletal muscle myoblast", "d": ["A skeletal muscle myoblast that is part of a skeletal mucle.  These cells are formed following acivation and division of skeletal muscle satellite cells. They form a transient population that is lost when they fuse to form skeletal muscle fibers."]}]}
{"type": "biolink:Cell", "ic": "87.120474278337809", "identifiers": [{"i": "UMLS:C1515140", "l": "T-Lymphocyte with a Post-Thymic Immunophenotype", "d": []}, {"i": "NCIT:C39573", "l": "T-Lymphocyte with a Post-Thymic Immunophenotype", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1183498", "l": "Primitive node cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4322672", "l": "CD23+ hemal cell", "d": []}]}
{"type": "biolink:Cell", "ic": "81.648881485605159", "identifiers": [{"i": "CL:0002543", "l": "vein endothelial cell", "d": ["An endothelial cell that is part of the vein."]}]}
{"type": "biolink:Cell", "ic": "74.37742281270377", "identifiers": [{"i": "UMLS:C1709082", "l": "Mucin-Producing Malignant Epithelial Cell", "d": []}, {"i": "NCIT:C54219", "l": "Mucin-Producing Malignant Epithelial Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C3829297", "l": "Lenti-D/ABCD1-transduced Autologous Hematopoietic Stem Cells", "d": []}, {"i": "NCIT:C111902", "l": "Lenti-D/ABCD1-transduced Autologous Hematopoietic Stem Cells", "d": ["Autologous CD34+ hematopoietic stem cells transduced with Lenti-D lentiviral vector encoding the human ATP-binding cassette, sub-family D, member 1 (ABCD1) cDNA, for the potential treatment of childhood cerebral adrenoleukodystrophy (CCALD). Upon administration of the lenti-D/ABCD1-transduced autologous hematopoietic stem cells, the cells proliferate, and some travel to the brain and differentiate into microglial cells. The expressed ABCD1 restores the function of ALD protein (ALDP) and aids in the treatment of CCALD.  In CCALD, the ABCD1 gene is mutated, leading to the inability of patients to metabolize very long chain fatty acids in cells of the brain."]}]}
{"type": "biolink:Cell", "ic": "92.728541327098611", "identifiers": [{"i": "CL:0002551", "l": "fibroblast of dermis", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1648298", "l": "Cells.CD7+CD8+", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C4725933", "l": "Autologous PSMA-4SCAR-expressing T-cells 4SCAR-PSMA", "d": []}, {"i": "NCIT:C150699", "l": "Autologous PSMA-4SCAR-expressing T-cells 4SCAR-PSMA", "d": ["A preparation of genetically modified autologous T-cells transduced with a replication incompetent, self-inactivating lentiviral vector expressing a fourth generation chimeric antigen receptor (4SCAR) consisting of an anti-prostate-specific membrane antigen (PSMA) single chain variable fragment (scFv) that is coupled to the costimulatory signaling domains CD28, CD137, CD27 and the zeta chain of the T-cell receptor (CD3zeta; CD3z), and is fused with the suicide gene inducible caspase 9 (iCasp9), with potential immunostimulating and antineoplastic activities. Upon administration, autologous PSMA-4SCAR-expressing T-cells 4SCAR-PSMA are directed to and induce selective toxicity in PSMA-expressing tumor cells. iCasp9 consists of a human FK506 drug-binding domain with an F36V mutation (FKBP12-F36V) linked to human caspase 9. If the administered T-cells lead to unacceptable side effects, the chemical homodimerizer AP1903 can be administered. AP1903 binds to the drug binding FKBP12-F36V domain and induces activation of caspase 9, which results in the apoptosis of the administered T-cells and enhances safety of this agent. PSMA, a tumor-associated antigen (TAA) and type II transmembrane protein, is expressed on the membrane of prostatic epithelial cells and overexpressed on prostate tumor cells. CD28, CD137 and CD27, T-cell surface-associated co-stimulatory molecules, are required for full T-cell activation and enhance both proliferation of T-cells and antitumor activity."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5401595", "l": "Allogenic Donor CD362-enriched Human Umbilical Cord-derived Mesenchymal Stem Cells", "d": []}]}
{"type": "biolink:Cell", "ic": "92.728541327098611", "identifiers": [{"i": "CL:0011002", "l": "lateral motor column neuron", "d": ["A motor neuron that is generated only on limb levels and send axons into the limb mesenchyme."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2325183", "l": "Type 1 vestibular sensory cell of stato-acoustic epithelium", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C4684830", "l": "Autologous Anti-BCMA-CAR-expressing CD4+/CD8+ T-lymphocytes FCARH143", "d": []}, {"i": "NCIT:C142807", "l": "Autologous Anti-BCMA-CAR-expressing CD4+/CD8+ T-lymphocytes FCARH143", "d": ["A preparation of ex vivo expanded autologous CD8+ and CD4+ T-cells that have been genetically modified to express a chimeric antigen receptor (CAR) specific for human B-cell maturation antigen (BCMA; tumor necrosis factor receptor superfamily member 17; TNFRSF17), with potential immunostimulating and antineoplastic activities. Upon administration, autologous anti-BCMA-CAR-expressing CD4+/CD8+ T-lymphocytes FCARH143 specifically recognize and induce selective toxicity in BCMA-expressing tumor cells. BCMA, a tumor specific antigen and a receptor for both a proliferation-inducing ligand (APRIL) and B-cell activating factor (BAFF), is a member of the tumor necrosis factor (TNF) receptor superfamily (TNFRSF) and plays a key role in plasma cell survival. BCMA is found on the surfaces of plasma cells and overexpressed on malignant plasma cells."]}]}
{"type": "biolink:Cell", "ic": "54.947183007037978", "identifiers": [{"i": "UMLS:C0229613", "l": "lymphoblast", "d": []}, {"i": "NCIT:C13013", "l": "Lymphoblast", "d": ["An immature lymphocyte that has enlarged in response to antigenic stimulation."]}, {"i": "SNOMEDCT:15433008", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5216286", "l": "Neutrophils.band form|NCnc|Pt|Body fld", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:1001606", "l": "foreskin keratinocyte", "d": ["Keratinocyte from foreskin."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5216293", "l": "Neutrophils|NCnc|Pt|Pericard fld", "d": []}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "CL:0002112", "l": "B220-positive CD38-negative unswitched memory B cell", "d": ["A B220-positive CD38-negative unswitched memory B cell is a CD38-negative unswitched memory B cell that has the phenotype B220-positive, CD38-negative, IgD-positive, CD138-negative, and IgG-negative."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5216260", "l": "Malignant cells|NCnc|Pt|CSF", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2333240", "l": "Non-nucleated solocyte", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C4053742", "l": "Anti-thyroglobulin mTCR-transduced Autologous Peripheral Blood Lymphocytes", "d": []}, {"i": "NCIT:C121552", "l": "Anti-thyroglobulin mTCR-transduced Autologous Peripheral Blood Lymphocytes", "d": ["Peripheral blood lymphocytes (PBLs) transduced with a gene encoding for a thyroglobulin (TG)-specific murine T-cell receptor (mTCR), with potential antineoplastic activity. PBLs are harvested from a thyroid cancer patient, and transfected with a retroviral vector that encodes the mTCR gene specific for the human TG antigen. The transduced PBLs are then expanded in culture. When reintroduced to the patient, these anti-TG mTCR-expressing PBLs target and bind to TG-overexpressing tumor cells, which results in both cytokine secretion and tumor cell lysis. TG is a thyroid-specific protein."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C3900029", "l": "Anti-CD22-CAR m971-BBz Lentiviral Vector-transduced Autologous T Lymphocytes", "d": []}, {"i": "NCIT:C120035", "l": "Anti-CD22-CAR m971-BBz Lentiviral Vector-transduced Autologous T Lymphocytes", "d": ["Autologous human T-lymphocytes transduced with a recombinant lentiviral vector encoding a chimeric T-cell receptor (chimeric antigen receptor or CAR) consisting of an anti-CD22 single chain variable fragment (scFv) derived from the monoclonal antibody (moAb) 971 (m971), and the co-stimulatory domain 4-1BB (CD137) coupled to the zeta chain of the TCR/CD3 complex (CD3-zeta), with potential immunostimulating and antineoplastic activities. Autologous peripheral blood lymphocytes (PBLs) from a patient with CD22-positive cancer are transduced with this lentiviral vector that encodes the CAR gene specific for CD22. After expansion in culture and reintroduction into the patient, the anti-CD22-CAR m971-BBz lentiviral vector-transduced autologous T-lymphocytes express anti-CD22-CAR on their cell surfaces and bind to the CD22 antigen on tumor cell surfaces. Subsequently, CD22-expressing tumor cells are lysed. CD22, a B-lineage-restricted, transmembrane phosphoglycoprotein, is expressed on malignant B-cells. m971 binds to a membrane proximal epitope on CD22 and has a higher binding affinity compared to other anti-CD22 moAb."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0000483", "l": "bombesin stimulating hormone secreting cell", "d": ["A peptide hormone secreting cell that secretes bombesin stimulating hormone."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1267991", "l": "CD105+ lymphocyte", "d": []}, {"i": "SNOMEDCT:117431005", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2328888", "l": "Cholinergic amacrine cell of retina", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1628974", "l": "Bone marrow derived hematopoietic stem cell", "d": []}, {"i": "SNOMEDCT:419880001", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2963403", "l": "Cells.CD79", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1440250", "l": "Cells.CD120a", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1623039", "l": "Veiled Cells", "d": []}, {"i": "SNOMEDCT:127942009", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5216264", "l": "Malignant cells|NCnc|Pt|Synv fld", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5432371", "l": "CLBS119", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002653", "l": "squamous endothelial cell", "d": ["A endothelial cell of the venule that is squamous shaped. This is in contrast to the cubodial shape of high endothelial venule cells."]}]}
{"type": "biolink:Cell", "ic": "92.728541327098611", "identifiers": [{"i": "CL:0004183", "l": "retinal ganglion cell B3", "d": ["A monostratified retinal ganglion cell with medium soma, sparse dendritic tree, and medium dendritic field."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1317332", "l": "Dysmorphic erythrocyte", "d": []}, {"i": "SNOMEDCT:725993007", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5166243", "l": "Hairy cells | Blood | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1979149", "l": "Blasts.CD135", "d": []}]}
{"type": "biolink:Cell", "ic": "69.388382942757389", "identifiers": [{"i": "UMLS:C1519468", "l": "Neoplastic Spindle-Shaped Smooth Muscle Cell", "d": []}, {"i": "NCIT:C36945", "l": "Neoplastic Spindle-Shaped Smooth Muscle Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C3896758", "l": "MAGE-A4-specific TCR Gene-transduced Autologous T Lymphocytes TBI-1201", "d": []}, {"i": "NCIT:C114978", "l": "MAGE-A4-specific TCR Gene-transduced Autologous T Lymphocytes TBI-1201", "d": ["Autologous human T-lymphocytes transduced with a retroviral vector encoding a T-cell receptor (TCR) specific for the human melanoma antigen A4 (MAGE-A4), with potential immunostimulatory and antineoplastic activities. Upon isolation, transduction, expansion ex vivo, and reintroduction into the patient, MAGE-A4-specific TCR gene-transduced T-lymphocytes TBI-1201 binds to tumor cells expressing MAGE-A4. This may result in both an inhibition of growth and increased cell death for MAGE-A4-expressing tumor cells. The tumor-associated antigen MAGE-A4 is overexpressed by a variety of cancer cell types."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0000942", "l": "thymic plasmacytoid dendritic cell", "d": ["A plasmacytoid dendritic cell developing in the thymus with phenotype CD11c-negative or low, CD45RA-positive, CD11b-negative, and CD123-positive."]}]}
{"type": "biolink:Cell", "ic": "86.236661114203869", "identifiers": [{"i": "CL:1000432", "l": "conjunctival epithelial cell", "d": ["An epithelial cell that is part of the conjunctiva."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5442136", "l": "bb2121", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:1001224", "l": "interlobulary vein smooth muscle cell", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C2827689", "l": "Natural Killer Cells ZRx101", "d": []}, {"i": "NCIT:C85466", "l": "Natural Killer Cells ZRx101", "d": ["A population of activated, immortalized, interleukin-2 (IL-2)-dependent, cytotoxic natural killer (NK) cells with potential antitumor activity. Natural killer cells ZRx101 are derived from NK-92 cells, having been modified to target tumor-associated antigens (TAAs) upregulated in certain types of cancer. The NK-92 cell line was originally isolated from a patient with large granular lymphocytic (LGL) leukemia/lymphoma."]}]}
{"type": "biolink:Cell", "ic": "88.140761698499901", "identifiers": [{"i": "CL:0002329", "l": "basal epithelial cell of tracheobronchial tree", "d": ["An epithelial cell type that lacks the columnar shape typical for other respiratory epithelial cells. This cell type is able to differentiate into other respiratory epithelial cells in response to injury."]}]}
{"type": "biolink:Cell", "ic": "79.246894609297499", "identifiers": [{"i": "CL:0002625", "l": "seminiferous tubule epithelial cell", "d": ["A cell of the seminiferous tubule epithelium."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5177621", "l": "Platelets | Fetus | Blood | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "CL:0000678", "l": "commissural neuron", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C3830333", "l": "EGFR CAR-CD3zeta-4-1BB-expressing Autologous T-Lymphocytes", "d": []}, {"i": "NCIT:C107191", "l": "EGFR CAR-CD3zeta-4-1BB-expressing Autologous T-Lymphocytes", "d": ["Autologous human T-lymphocytes transduced with a retroviral vector encoding an anti-epidermal growth factor receptor (EGFR) chimeric T cell receptor (chimeric antigen receptor or CAR) gene coupled to the signaling domains from both CD3 zeta and CD137 (4-1BB), with potential immunostimulatory and antineoplastic activities. Upon administration, the chimeric EGFR antigen receptor-modified autologous T lymphocytes bind to the EGFR antigen on tumor cell surfaces; subsequently, EGFR-expressing tumor cells may be lysed. Following binding to EGFR, the 4-1BB co-stimulatory molecule signaling domain enhances both activation and signaling. Inclusion of the 4-1BB signaling domain may also increase the antitumor activity when compared to the inclusion of the CD3-zeta chain alone. EGFR, a receptor tyrosine kinase (RTK) overexpressed by a variety of cancer cell types, plays key roles in tumor cell proliferation and tumor angiogenesis."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0009097", "l": "embryonic skeletal muscle fiber", "d": ["A skeletal muscle fiber found in an embryo. In mammalian embryos, skeletal muscle expresses myosin heavy chain-embryonic (MyHC-emb, encoded by the MYH3 gene), which regulates skeletal muscle development."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5216282", "l": "Mononuclear cells|NCnc|Pt|Synv fld", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5556788", "l": "Anti-CD7 CAR T Cells SenL-T7", "d": []}, {"i": "NCIT:C181024", "l": "Anti-CD7 CAR T Cells SenL-T7", "d": ["A preparation of T-lymphocytes that have been genetically engineered to express a chimeric antigen receptor (CAR) directed against the tumor-associated antigen (TAA) CD7, with potential immunostimulating and antineoplastic activities. Upon administration, the anti-CD7 CAR T cells SenL-T7 specifically recognize and bind to CD7-expressing tumor cells, resulting in specific T-cell-mediated tumor cell lysis. CD7 is a transmembrane glycoprotein expressed by T-cells and natural killer (NK) cells and their precursors. It is expressed in the majority of lymphoblastic T-cell leukemias and lymphomas and in a subset of peripheral T-cell lymphomas."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1370155", "l": "Lymphocytes+Monocytes", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:4033004", "l": "smooth muscle cell of taenia coli", "d": ["A(n) smooth muscle cell that is part of a(n) taenia coli."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0230517", "l": "Dividing cell", "d": []}, {"i": "SNOMEDCT:35853008", "d": []}]}
{"type": "biolink:Cell", "ic": "71.163959742754642", "identifiers": [{"i": "UMLS:C4527420", "l": "T-cell Receptor-engineered T-cells", "d": []}, {"i": "NCIT:C138180", "l": "T-cell Receptor-engineered T-cells", "d": ["T-lymphocytes that have been engineered to express a modified antigen-specific T-cell receptor (TCR). In cancer therapy, the TCR-engineered T-cell recognizes a tumor-specific protein fragment complexed with major histocompatibility complex (MHC) molecules on the surface of the tumor cells and kills the tumor cell."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1522131", "l": "Leukocyte - Lymphocyte - T-Lymphocyte (MMHCC)", "d": []}, {"i": "NCIT:C22582", "l": "Mouse T-Lymphocyte", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C4086920", "l": "Tumor Peptide-loaded Myeloid Dendritic Cells", "d": []}, {"i": "NCIT:C124055", "l": "Tumor Peptide-loaded Myeloid Dendritic Cells", "d": ["A cell-based cancer vaccine composed of myeloid dendritic cells (myDCs) pulsed with tumor peptides with potential immunostimulatory and antineoplastic activities. Upon administration, the tumor peptide-loaded myDCs stimulate a specific cytotoxic T-lymphocyte (CTL) response against the tumor cells, resulting in tumor cell lysis."]}]}
{"type": "biolink:Cell", "ic": "46.04059485507117", "identifiers": [{"i": "UMLS:C1512385", "l": "Hematopoietic and Lymphoid Cell", "d": []}, {"i": "NCIT:C32725", "l": "Hematopoietic and Lymphoid Cell", "d": ["One of the cells of the blood or bone marrow, a leukocyte or erythrocyte."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157472", "l": "CD3+TCR alpha beta+ cells | Blood | Cell markers", "d": []}]}
{"type": "biolink:Cell", "ic": "89.347505587204751", "identifiers": [{"i": "UMLS:C1709209", "l": "Neoplastic Thyroid Gland Follicular Signet Ring Cell", "d": []}, {"i": "NCIT:C47831", "l": "Neoplastic Thyroid Gland Follicular Signet Ring Cell", "d": ["A neoplastic thyroid gland follicular cell with cytoplasmic vacuole and eccentrically placed nucleus."]}]}
{"type": "biolink:Cell", "ic": "54.412894886682935", "identifiers": [{"i": "UMLS:C1514048", "l": "Neoplastic Neuroepithelial Cell", "d": []}, {"i": "NCIT:C37125", "l": "Neoplastic Neuroepithelial Cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5216211", "l": "Erythrocytes|NCnc|Pt|Body fld", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1267939", "l": "Lymphocyte positive for CD49D antigen", "d": []}, {"i": "SNOMEDCT:117382009", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0001055", "l": "CD14-positive, CD16-low monocyte", "d": ["An intermediate monocyte that is CD14-positive and with low amounts of CD16."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5173439", "l": "Monocytes | Vitreous fluid | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5382940", "l": "Interferon-gamma producing HLA-A2 Cytomegalovirus specific CD8 cells | Blood | Cell markers", "d": []}]}
{"type": "biolink:Cell", "ic": "92.728541327098611", "identifiers": [{"i": "CL:4023026", "l": "direct pathway medium spiny neuron", "d": ["A medium spiny neuron that expresses dopamine type 1 receptors and projects to the globus pallidus internus or the substantia nigra pars reticulata."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4510907", "l": "Blast cell positive for CD14 antigen", "d": []}, {"i": "SNOMEDCT:724252003", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C3890720", "l": "PC-3 cell line", "d": []}, {"i": "NCIT:C117219", "l": "PC-3", "d": ["An adenocarcinoma cell line established in 1979 from a bone metastasis from a 62 year old Caucasian male patient with stage IV prostate carcinoma."]}, {"i": "MESH:D000078722", "l": "PC-3 Cells", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5174617", "l": "Neutrophils | Fetus | Blood | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0009026", "l": "enterocyte of appendix", "d": ["An enterocyte that is a part of a vermiform appendix."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1515989", "l": "Angioblast", "d": []}, {"i": "NCIT:C33934", "l": "Angioblast", "d": ["A pluripotent cell that can develop into a vascular endothelial cell."]}]}
{"type": "biolink:Cell", "ic": "92.728541327098611", "identifiers": [{"i": "UMLS:C1514014", "l": "Neoplastic Maturing Ganglion Cell", "d": []}, {"i": "NCIT:C42093", "l": "Neoplastic Maturing Ganglion Cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C3656577", "l": "Cells.CD158a", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0038856", "l": "Suppressor T Lymphocyte", "d": []}, {"i": "SNOMEDCT:50146007", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:1000364", "l": "transitional myocyte of anterior internodal tract", "d": ["A transitional myocyte that is part of the anterior internodal tract."]}]}
{"type": "biolink:Cell", "ic": "69.010064724098413", "identifiers": [{"i": "CL:0000025", "l": "egg cell", "d": ["A female gamete where meiosis has progressed to metaphase II and is able to participate in fertilization."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:4030026", "l": "BEST4+ intestinal epithelial cell, human", "d": ["An absorptive epithelial cell of the human intestine expressing bestrophin-4 (BEST4) calcium-activated ion channels."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5776905", "l": "Megakaryocytes | Blood | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157359", "l": "CD19+IgM+ cells | Blood | Cell markers", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5171662", "l": "Lymphocytes | Fetus | Pleural fluid | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1182692", "l": "Clear cell of eccrine sweat gland", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C3176906", "l": "Cells.cytoplasmic CD3", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0229608", "l": "Histioblast", "d": []}, {"i": "SNOMEDCT:1605008", "d": []}]}
{"type": "biolink:Cell", "ic": "90.82444074280258", "identifiers": [{"i": "CL:0000494", "l": "UV sensitive photoreceptor cell", "d": ["A photoreceptor cell that detects ultraviolet light."]}]}
{"type": "biolink:Cell", "ic": "81.247621244257502", "identifiers": [{"i": "UMLS:C1514019", "l": "Neoplastic Medium-Sized to Large Lymphocyte", "d": []}, {"i": "NCIT:C36992", "l": "Neoplastic Medium-Sized to Large Lymphocyte", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1181294", "l": "Endo-epithelial cell", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5707550", "l": "Donor TCR Alpha/Beta/CD19-depleted Mononuclear Cell-enriched Activated Natural Killer Cells", "d": []}, {"i": "NCIT:C188056", "l": "Donor TCR Alpha/Beta/CD19-depleted Mononuclear Cell-enriched Activated Natural Killer Cells", "d": ["A preparation of donor-derived, haploidentical, cytokine-activated natural killer (NK) cells enriched with mononuclear cells from haploidentical donor that have been depleted of T-cell receptor (TCR) alpha and beta (TCRa/b+) as well as CD19-positive (CD19+) cells, that may potentially be used for immune reconstitution purposes. Upon administration, the donor TCR alpha/beta/CD19-depleted mononuclear cell-enriched activated NK cells may enhance immune reconstitution. The depletion of alpha/beta T-cells, which are implicated in the adaptive immune response that mediates graft-versus-host disease (GvHD), may promote rapid and sustained engraftment, immune reconstitution, and may prevent or reduce the development of GvHD. The depletion of CD19+ B-cells may reduce the risk of Epstein-Barr virus (EBV)-driven post-transplant lymphoproliferative disorders."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1956101", "l": "Cumulus Cells", "d": []}, {"i": "MESH:D054885", "l": "Cumulus Cells", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0205878", "l": "Glomus tympanicum", "d": []}, {"i": "MESH:D043485", "l": "Glomus Tympanicum", "d": []}, {"i": "SNOMEDCT:181381004", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:1001107", "l": "kidney loop of Henle thin ascending limb epithelial cell", "d": ["An epithelial cell that is part of some loop of Henle thin ascending limb."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002175", "l": "primary follicular cell of ovary", "d": ["A cell within the primary follicle of the ovary."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002660", "l": "luminal cell of acinus of lactiferous gland", "d": ["A luminal epithelial cell of mammary gland located in acinus of structure."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1267944", "l": "Lymphocyte positive for CD52 antigen", "d": []}, {"i": "SNOMEDCT:117387003", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C2346881", "l": "Autologous Ad-CD154-Transduced CLL B Cells", "d": []}, {"i": "NCIT:C68842", "l": "Autologous Ad-CD154-Transduced CLL B Cells", "d": ["An autologous tumor cell vaccine containing chronic lymphocytic leukemia (CLL) B cells transduced with an adenoviral vector carrying chimeric CD154 (ad-CD154) with potential antineoplastic activity. Administration of autologous ad-CD154 transduced CLL B cells may result in increases in the numbers of leukemia-specific CD4+ T cells and high serum-levels of IL-12 and IFN-gamma. Due to ligation of CD154 to CD40 on CLL cells, this agent may induce CLL cells to express the proapoptotic molecule BID and death receptors CD95 (Fas) and DR5, rendering CLL B cells first resistant and then sensitive to Fas-mediated apoptosis. In addition, autologous ad-CD154 transduced CLL B cells may induce MHC class I-dependent cytotoxic T lymphocyte (CTL) responses against autologous leukemia cells. CD154 is a type II membrane glycoprotein and ligand for CD40; both molecules are important in cognate co-stimulatory cell-cell interactions."]}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "CL:1000438", "l": "epithelial cell of wall of inferior part of anal canal", "d": ["An epithelial cell that is part of the wall of inferior part of anal canal."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1440314", "l": "Cells.CD45+CD14+", "d": []}]}
{"type": "biolink:Cell", "ic": "80.869303025598512", "identifiers": [{"i": "CL:4023058", "l": "mesothelial fibroblast of the leptomeninx", "d": ["A mesothelial fibroblast found in the leptomeninx."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5421258", "l": "Original Tumor Cell Sample", "d": []}, {"i": "NCIT:C172293", "l": "Original Tumor Cell Sample", "d": ["A sample comprised of cells that were isolated from a tumor and have not been cultured or expanded."]}]}
{"type": "biolink:Cell", "ic": "92.728541327098611", "identifiers": [{"i": "NCIT:C12644", "l": "Motor Neuron", "d": ["An efferent neuron that sends impulses from the central nervous system to skeletal muscles."]}]}
{"type": "biolink:Cell", "ic": "80.511444690059548", "identifiers": [{"i": "CL:0000867", "l": "secondary lymphoid organ macrophage", "d": ["A tissue-resident macrophage found in a secondary lymphoid organ."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:4032000", "l": "club-like cell of the urethral epithelium", "d": ["An epithelial cell of the urethra that has an expression profile similar to lung club cells. Club-like cells of the urethra epithelium are similar to lung club cells in their expression of SCGB1A1 and in their enrichment of immunomodulatory programs."]}]}
{"type": "biolink:Cell", "ic": "64.483855464319362", "identifiers": [{"i": "CL:0000514", "l": "smooth muscle myoblast", "d": ["A precursor cell destined to differentiate into smooth muscle myocytes."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5173444", "l": "Monocytes/100 cells | Bone marrow | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5171867", "l": "Macrophages | Pericardial fluid | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2337780", "l": "Dendritic reticular cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4323724", "l": "Diencephalic neural crest cell group", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002022", "l": "Ly-76 high positive erythrocyte", "d": ["An enucleate erythrocyte that is Lyg-76-high."]}]}
{"type": "biolink:Cell", "ic": "74.953330836288131", "identifiers": [{"i": "UMLS:C1514010", "l": "Neoplastic Lobular Epithelial Cell", "d": []}, {"i": "NCIT:C36878", "l": "Neoplastic Lobular Epithelial Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "87.120474278337809", "identifiers": [{"i": "UMLS:C1512141", "l": "ES ES Cell Line", "d": []}, {"i": "NCIT:C20248", "l": "ES ES Cell Line", "d": []}]}
{"type": "biolink:Cell", "ic": "66.08567671964029", "identifiers": [{"i": "CL:0002274", "l": "histamine secreting cell", "d": ["A cell type that secretes histamine."]}]}
{"type": "biolink:Cell", "ic": "92.728541327098611", "identifiers": [{"i": "CL:1000491", "l": "mesothelial cell of pleura", "d": ["A mesothelial cell that is part of the pleura."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5706536", "l": "Autologous MuSK-CD3z/4-1BB-expressing Chimeric Autoantibody Receptor T-cells MuSK-CAART", "d": []}, {"i": "NCIT:C189084", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1440331", "l": "Cells.CD52", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1511638", "l": "Cytotrophoblastic Cell", "d": []}, {"i": "NCIT:C38575", "l": "Cytotrophoblastic Cell", "d": ["A polygonal, mononucleate cell resembling the cells of the inner layer of the trophoblast, having prominent nucleoli and clear, eosinophilic or basophilic cytoplasm."]}]}
{"type": "biolink:Cell", "ic": "92.728541327098611", "identifiers": [{"i": "CL:0000779", "l": "multinuclear osteoclast", "d": ["A specialized multinuclear osteoclast associated with the absorption and removal of bone."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5417884", "l": "Autologous Anti-CD19 TAC-T cells TAC01-CD19", "d": []}, {"i": "NCIT:C172055", "l": "Autologous Anti-CD19 TAC-T cells TAC01-CD19", "d": ["A preparation of autologous T-lymphocytes genetically engineered with a T cell Antigen Coupler (TAC), comprising of a domain that targets the tumor-associated antigen (TAA) cluster of differentiation 19 (CD 19) and another domain that binds to the endogenous T cell receptor (TCR), anchored in the membrane via the CD4 co-receptor domain, with potential immunostimulating and antineoplastic activities. Upon administration, autologous anti-CD19 TAC-T cells TAC01-CD19 targets and binds to CD19-expressing tumor cells and activates TCR-mediated signaling pathways, leading to T cell-mediated killing of CD19-expressing tumor cells. CD19 antigen is a B-cell specific cell surface antigen overexpressed in B-cell lineage malignancies."]}]}
{"type": "biolink:Cell", "ic": "90.82444074280258", "identifiers": [{"i": "CL:2000016", "l": "lung microvascular endothelial cell", "d": ["Any lung endothelial cell that is part of a microvascular endothelium."]}]}
{"type": "biolink:Cell", "ic": "61.478227635499344", "identifiers": [{"i": "UMLS:C0025201", "l": "melanocyte", "d": []}, {"i": "NCIT:C12591", "l": "Melanocyte", "d": []}, {"i": "MESH:D008544", "l": "Melanocytes", "d": []}, {"i": "SNOMEDCT:9683001", "d": []}]}
{"type": "biolink:Cell", "ic": "82.076046914303362", "identifiers": [{"i": "CL:1000317", "l": "intestinal villus goblet cell", "d": ["A goblet cell that is part of the epithelium of intestinal villus."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157423", "l": "CD3- CD8- CD57+ Cells | Blood | Cell markers", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2326252", "l": "Monopoietic cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0684123", "l": "Late erythroblast", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1182650", "l": "Ciliary muscle cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157669", "l": "CD8+CD38+ cells | Blood | Cell markers", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:4030014", "l": "kidney loop of Henle long descending thin limb inner medulla epithelial cell", "d": ["Epithelial cell of the descending thin limb of the long loop (juxtamedullary) nephron that spans the inner medulla. It is known in some mammalian species that the long descending limb of the loop of Henle in the inner medulla selectively expresses the nuclear receptor Nr2e3, the Ig kappa chain Igkc, and the secreted protein dermokine (Dmkn). SLC14A2, which expresses a urea transporter, is also expressed in the inner medulla."]}]}
{"type": "biolink:Cell", "ic": "81.648881485605159", "identifiers": [{"i": "CL:0002041", "l": "immature NK T cell stage III", "d": ["A CD24-low, CD44-positive, DX5-low, NK1.1-negative NK T cell."]}]}
{"type": "biolink:Cell", "ic": "90.82444074280258", "identifiers": [{"i": "CL:0002387", "l": "arthroconidium", "d": ["Cylindrical spore formed by development and compartmentation of hyphae; the hyphae are often supporting blastoconidiophores."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0000977", "l": "IgG short lived plasma cell", "d": ["A short lived plasma cell that secretes IgG."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C4289582", "l": "EpCAM-specific CAR-expressing Autologous T-lymphocytes", "d": []}, {"i": "NCIT:C126801", "l": "EpCAM-specific CAR-expressing Autologous T-lymphocytes", "d": ["A preparation of autologous T-lymphocytes that have been genetically modified to express a chimeric antigen receptor (CAR) specific for the antigen epithelial cell adhesion molecule (EpCAM), with potential immunostimulating and antineoplastic activities. Upon administration, the EpCAM-specific CAR-expressing autologous T-lymphocytes specifically recognize and bind to EpCAM-expressing tumor cells, resulting in tumor cell lysis. EpCAM, a cell surface protein, is expressed by a variety of tumor cells."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1979063", "l": "Blasts.CD1", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C3850145", "l": "Commissural Interneurons", "d": []}, {"i": "MESH:D066294", "l": "Commissural Interneurons", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5155288", "l": "Blasts/100 cells | Lymph node | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5575125", "l": "JNJ-68284528", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1519120", "l": "SA01", "d": []}, {"i": "NCIT:C20264", "l": "SA01", "d": ["Provider: Goteborg University, Goteborg, Sweden. No information from provider. This cell line meets the criteria for the use of human embryonic stem cells by federally funded researchers."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C0005712", "l": "Structure of blastomere", "d": []}, {"i": "NCIT:C12518", "l": "Blastomere", "d": ["A cell formed by cleavage division during embryogenesis."]}, {"i": "MESH:D001757", "l": "Blastomeres", "d": []}, {"i": "SNOMEDCT:296383004", "d": []}, {"i": "SNOMEDCT:367618007", "d": []}]}
{"type": "biolink:Cell", "ic": "56.890448006900634", "identifiers": [{"i": "CL:0000766", "l": "myeloid leukocyte", "d": ["A cell of the monocyte, granulocyte, or mast cell lineage."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157385", "l": "CD20+FMC7+ cells | Cerebral spinal fluid | Cell markers", "d": []}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "CL:0002195", "l": "hepatic stem cell", "d": ["A stem cell that can give rise to the cells of the liver. The term usually refers to the self-renewing pool of hepatocyte precursors in the adult liver (differently from 'hepatoblast', often used for fetal precursors of hepatocytes)."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1510964", "l": "Atypical Spindle Melanocyte", "d": []}, {"i": "NCIT:C36868", "l": "Atypical Spindle Melanocyte", "d": []}]}
{"type": "biolink:Cell", "ic": "66.661584743224637", "identifiers": [{"i": "CL:0000893", "l": "thymocyte", "d": ["An immature T cell located in the thymus."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5177800", "l": "Polymorphonuclear cells/leukocytes | Synovial fluid | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "ic": "85.457082654197222", "identifiers": [{"i": "CL:0000913", "l": "effector memory CD8-positive, alpha-beta T cell", "d": ["CD8-positive, alpha-beta memory T cell with the phenotype CCR7-negative, CD127-positive, CD45RA-negative, CD45RO-positive, and CD25-negative."]}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "UMLS:C1514740", "l": "Reactive Plasma Cell", "d": []}, {"i": "NCIT:C40563", "l": "Reactive Plasma Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C4684836", "l": "Autologous Dendritic Cells Pulsed with MART-1 (26-35) Peptide", "d": []}, {"i": "NCIT:C142814", "l": "Autologous Dendritic Cells Pulsed with MART-1 (26-35) Peptide", "d": ["A cell-based vaccine consisting of autologous HLA-A2*0201-restricted dendritic cells (DC), which were derived from patient-harvested adherent peripheral blood monocytes cultured in vitro with granulocyte-macrophage colony-stimulating factor (GM-CSF) and interleukin-4 (IL-4), that were pulsed with a peptide fragment comprised of amino acid residues 26 through 35 of melanoma antigen recognized by T-cells 1 (MART-1 (26-35)), with potential immunostimulatory and antineoplastic activities. Upon intradermal vaccination, autologous DC pulsed with MART-1 (26-35) peptide may stimulate the host immune system to mount a cytotoxic T-lymphocyte immune response against tumor cells expressing MART-1. MART-1, a protein involved in melanosome biogenesis, is overexpressed by melanoma cells. The MART-1 (26-35) peptide is highly immunogenic for the HLA-A2*0201 haplotype."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C3274612", "l": "Allogeneic CD19-specific CAR-modified CD8 Plus Central Memory-derived Virus-specific T Cells", "d": []}, {"i": "NCIT:C99215", "l": "Allogeneic CD19-specific CAR-modified CD8 Plus Central Memory-derived Virus-specific T Cells", "d": ["A preparation of allogeneic Epstein-Barr virus (EBV)- and human cytomegalovirus (CMV)-specific CD8+ central memory-derived T effector-lymphocytes that have been genetically modified to express a chimeric antigen receptor (CAR) anti-CD19/CD3 zeta chain fusion protein coupled to the intracellular signal domain of CD28 antigen, with potential immunostimulating, anti-viral and antineoplastic activities. Upon infusion, allogeneic CD19-specific CAR-modified CD8+ central memory-derived virus-specific T cells directs the T-lymphocytes to CD19-expressing tumor cells, stimulating a selective toxicity to tumor cells which may eventually result in tumor cell lysis. CD19 antigen is a B-cell specific cell surface antigen expressed in all B-cell lineage malignancies. The viral specific T-cells exert antiviral immunity."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2337416", "l": "Chromophilic cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0333857", "l": "Large non-cleaved cell", "d": []}, {"i": "SNOMEDCT:55134005", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C3495541", "l": "A1 noradrenaline cells", "d": []}]}
{"type": "biolink:Cell", "ic": "78.185623981295834", "identifiers": [{"i": "CL:0000589", "l": "cochlear inner hair cell", "d": ["A bulbous cell that is medially placed in one row in the organ of Corti. In contrast to the outer hair cells, the inner hair cells are fewer in number, have fewer sensory hairs, and are less differentiated."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5446599", "l": "Autologous CD19 CAR-expressing T-cells YTB323", "d": []}, {"i": "NCIT:C175534", "l": "Autologous CD19 CAR-expressing T-cells YTB323", "d": ["A preparation of autologous T-lymphocytes that are genetically engineered to express a chimeric antigen receptor (CAR) specific for the tumor-associated antigen (TAA) CD19, with potential immunostimulating and antineoplastic activities. Upon intravenous administration, the autologous CD19 CAR-expressing T-cells YTB323 are directed to and induce selective toxicity in CD19-expressing tumor cells. CD19 antigen is a B-cell specific cell surface antigen expressed in all B-cell lineage malignancies."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:4030017", "l": "epithelial cell of late distal convoluted tubule", "d": ["An epithelial cell located in the late distal convoluted tubule."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1440278", "l": "Cells.CD29", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157349", "l": "CD19+21- cells | Blood | Cell markers", "d": []}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "UMLS:C1880955", "l": "Giant Melanoma Cell", "d": []}, {"i": "NCIT:C62346", "l": "Giant Melanoma Cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0682700", "l": "Peripheral neuron", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0010004", "l": "mononuclear cell of bone marrow", "d": ["A mononuclear cell that is part_of a bone marrow."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2338142", "l": "Non-nucleated colligocyte", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5176574", "l": "Pencil cells | Blood | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "ic": "80.511444690059548", "identifiers": [{"i": "CL:0001059", "l": "common myeloid progenitor, CD34-positive", "d": ["A progenitor cell committed to myeloid lineage, including the megakaryocyte and erythroid lineages. These cells are CD34-positive, and express Gata1, Gata2, C/EBPa, and Pu.1."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1306700", "l": "Platycyte", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002606", "l": "astrocyte of the spinal cord", "d": ["An astrocyte of the spinal cord."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002557", "l": "fibroblast of pulmonary artery", "d": ["A fibroblast of pulmonary artery."]}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "CL:0002631", "l": "epithelial cell of upper respiratory tract", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0000870", "l": "Peyer's patch macrophage", "d": ["A gut-associated lymphoid tissue macrophage found in the Peyer's patches."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5206457", "l": "Engineered Human Umbilical Vein Endothelial Cells AB-205", "d": []}, {"i": "NCIT:C162248", "l": "Engineered Human Umbilical Vein Endothelial Cells AB-205", "d": ["A population of ex vivo expanded, genetically engineered CD31 (platelet endothelial cell adhesion molecule; PECAM-1)-positive human umbilical vein endothelial cells (HUVECs) derived from human umbilical vein tissue, that can be used to enhance the hematopoietic stem and progenitor cells (HSPCs) transplantation potential and improve blood cell recovery. Following autologous stem cell transplantation (ASCT) and upon the administration of the engineered HUVEC AB-205, the endothelial cells secrete angiocrine growth factors and interact with the HSPCs, thereby forming endothelial cell network structures and improving engraftment potential. AB-205 also interacts with injured or damaged vascular niche cells, thereby promoting blood cell recovery and improving tissue regeneration. This enhances recovery from toxicities related to chemo/radiation regimens."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5164690", "l": "FLAER cells | Blood | Cell markers", "d": []}]}
{"type": "biolink:Cell", "ic": "63.561493752554874", "identifiers": [{"i": "CL:0000110", "l": "peptidergic neuron", "d": ["A neuron that uses neuropeptides as transmitters."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1268003", "l": "Lymphocyte positive for CD198 antigen", "d": []}, {"i": "SNOMEDCT:117443006", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C3534344", "l": "100 round cells", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5180537", "l": "Secondary Spermatocytes | Semen | Fertility testing", "d": []}]}
{"type": "biolink:Cell", "ic": "87.120474278337809", "identifiers": [{"i": "CL:0000858", "l": "fast muscle myoblast", "d": ["A skeletal muscle myoblast that differentiates into fast muscle fibers."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1441374", "l": "Cells.C4", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4518173", "l": "Population of all pitted erythrocytes in portion of fluid", "d": []}, {"i": "SNOMEDCT:725388003", "d": []}]}
{"type": "biolink:Cell", "ic": "78.695011174409487", "identifiers": [{"i": "CL:0000970", "l": "unswitched memory B cell", "d": ["An unswitched memory B cell is a memory B cell that has the phenotype IgM-positive, IgD-positive, CD27-positive, CD138-negative, IgG-negative, IgE-negative, and IgA-negative."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2339101", "l": "Serous cell of epithelium of trachea", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5186974", "l": "Reticulocytes | Fetus | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5171964", "l": "Malignant cells | Pleural fluid | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "ic": "83.023198044254755", "identifiers": [{"i": "UMLS:C1706983", "l": "Bone Marrow Stem Cell with Some Commitment to Monocytic Differentiation", "d": []}, {"i": "NCIT:C42780", "l": "Bone Marrow Stem Cell with Some Commitment to Monocytic Differentiation", "d": ["A primitive, undifferentiated blood cell which can undergo division and tends to give rise to a blood cell of the monocyte lineage."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:1000839", "l": "kidney proximal straight tubule epithelial cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2325342", "l": "Set of cholinergic cells of substantia innominata [Ch4]", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5556428", "l": "Allogeneic AdV/CMV/EBV-specific T-lymphocytes", "d": []}, {"i": "NCIT:C180509", "l": "Allogeneic AdV/CMV/EBV-specific T-lymphocytes", "d": ["A preparation of human leukocyte antigen (HLA)-matched or HLA-mismatched, allogeneic CD4+ and CD8+ T-lymphocytes, ex vivo incubated with synthetic peptides of the viral antigens of the three human viruses adenovirus (AdV), cytomegalovirus (CMV) and Epstein-Barr virus (EBV), with potential antiviral activity. Upon administration of the allogeneic AdV/CMV/EBV-specific T-lymphocytes after allogeneic hematopoietic stem cell transplantation (HSCT), these T-lymphocytes may kill AdV, CMV, and/or EBV-infected cells, and may prevent or reduce the severity of viral infections by these pathogens."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5216280", "l": "Mononuclear cells|NCnc|Pt|Periton fld", "d": []}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "UMLS:C1518368", "l": "Non-Keratinizing Malignant Small Squamous Cell", "d": []}, {"i": "NCIT:C36790", "l": "Non-Keratinizing Malignant Small Squamous Cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C3827096", "l": "Anti-CD19-CAR-CD3zeta-4-1BB-Expressing Allogenic Natural Killer Cells", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:4023039", "l": "amygdala excitatory neuron", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1704617", "l": "Perivascular Epithelioid Cell", "d": []}, {"i": "NCIT:C45634", "l": "Perivascular Epithelioid Cell", "d": ["A perivascular cell with abundant clear or eosinophilic cytoplasm that contains glycogen. -- 2005"]}]}
{"type": "biolink:Cell", "ic": "84.128890093485552", "identifiers": [{"i": "CL:0000745", "l": "retina horizontal cell", "d": ["A neuron that laterally connects other neurons in the inner nuclear layer of the retina."]}]}
{"type": "biolink:Cell", "ic": "70.071335352100078", "identifiers": [{"i": "CL:0000017", "l": "spermatocyte", "d": ["A male germ cell that develops from spermatogonia. The euploid primary spermatocytes undergo meiosis and give rise to the haploid secondary spermatocytes which in turn give rise to spermatids."]}]}
{"type": "biolink:Cell", "ic": "84.128890093485552", "identifiers": [{"i": "UMLS:C1517714", "l": "Lactotrophs", "d": []}, {"i": "NCIT:C32911", "l": "Lactotroph Cell", "d": []}, {"i": "MESH:D052682", "l": "Lactotrophs", "d": []}, {"i": "SNOMEDCT:65357006", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0545589", "l": "Blood monocytic cell", "d": []}]}
{"type": "biolink:Cell", "ic": "90.82444074280258", "identifiers": [{"i": "UMLS:C1882061", "l": "Neoplastic Small Sex Cord-Stromal Cell", "d": []}, {"i": "NCIT:C61425", "l": "Neoplastic Small Sex Cord-Stromal Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1708895", "l": "Malignant Neuroendocrine Small to Intermediate Size Cell", "d": []}, {"i": "NCIT:C45982", "l": "Malignant Neuroendocrine Small to Intermediate Size Cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2362002", "l": "CD41-Bf", "d": []}]}
{"type": "biolink:Cell", "ic": "86.236661114203869", "identifiers": [{"i": "UMLS:C1882961", "l": "Round Adenocarcinoma Cell", "d": []}, {"i": "NCIT:C54417", "l": "Round Adenocarcinoma Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0008020", "l": "skeletal muscle satellite myogenic cell", "d": ["A skeletal muscle satellite cell that undergoes symmetric division to produce two adult skeleltal muscle myoblasts."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1440937", "l": "Lymphocytes.activated T cells", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C3832086", "l": "Human Cord Blood Hematopoietic Progenitor Cell 500000000 in 35 mL INTRAVENOUS INJECTION, SOLUTION [ALLOCORD]", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0333860", "l": "ABNORMAL MEGAKARYOCYTES AND PLATELETS", "d": []}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "CL:2000097", "l": "midbrain dopaminergic neuron", "d": ["Any dopaminergic neuron that is part of a midbrain."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:4030035", "l": "dental pulp stem cell", "d": ["A dental pulp cell that possesses stem-cell-like qualities, including self-renewal capability and multi-lineage differentiation."]}]}
{"type": "biolink:Cell", "ic": "88.140761698499901", "identifiers": [{"i": "CL:0000830", "l": "basophilic promyelocyte", "d": ["A promyelocyte committed to the basophil lineage."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0000688", "l": "perijunctional fibroblast", "d": ["A fibroblast-like cell that provides support at neuromuscular junctions in vertebrates and are localized outside the synaptic basal lamina."]}]}
{"type": "biolink:Cell", "ic": "86.236661114203869", "identifiers": [{"i": "CL:0000227", "l": "binucleate cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0682552", "l": "Parenchymal cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5163721", "l": "Erythrocytes | Peritoneal fluid | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0003002", "l": "G1 retinal ganglion cell", "d": ["A retinal ganglion cell that has a small dendritic field and a medium dendritic arbor with post sympatic terminals in sublaminar layer S3."]}]}
{"type": "biolink:Cell", "ic": "71.163959742754642", "identifiers": [{"i": "UMLS:C1514224", "l": "Poorly Differentiated Neoplastic Astrocyte", "d": []}, {"i": "NCIT:C37137", "l": "Poorly Differentiated Neoplastic Astrocyte", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5172509", "l": "Mesothelial cells | Vitreous fluid | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4697023", "l": "Cells.CD27+CD62L+", "d": []}]}
{"type": "biolink:Cell", "ic": "85.457082654197222", "identifiers": [{"i": "CL:0000443", "l": "calcitonin secreting cell", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0009072", "l": "medullary thymic epithelial cell type 2", "d": ["A thymic medullary epithelial cell that expresses AIRE or other canonical markers of mature mTECs like Fezf2."]}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "UMLS:C1517732", "l": "Large Keratinocyte", "d": []}, {"i": "NCIT:C36750", "l": "Large Keratinocyte", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0333800", "l": "Blister cell", "d": []}, {"i": "SNOMEDCT:81140002", "d": []}]}
{"type": "biolink:Cell", "ic": "80.869303025598512", "identifiers": [{"i": "CL:0000218", "l": "myelinating Schwann cell", "d": ["A neuroglial cell of the peripheral nervous system which forms the insulating myelin sheaths of peripheral axons."]}]}
{"type": "biolink:Cell", "ic": "89.347505587204751", "identifiers": [{"i": "CL:4040003", "l": "fetal pre-type II pneumocyte", "d": ["Precursor of type II pneumocyte. These cells do not have lamellar bodies, which are a marker of type II pneumocyte maturity."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5181132", "l": "Smudge cells | Blood | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002089", "l": "group 2 innate lymphoid cell, mouse", "d": ["A group 2 innate lymphoid cell in the mouse capable of secreting IL-13 in response to a helminth infection. This cell is lineage-negative, ICOS-positive, IL1RL1-positive, IL7Ralpha-positive, and IL17Br-positive."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2736933", "l": "Cells.CD3+CD8+CD45+", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5182506", "l": "Synovial cells | Body fluid | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5180817", "l": "Sezary cells | Blood | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "ic": "75.26123597683771", "identifiers": [{"i": "UMLS:C1514018", "l": "Neoplastic Medium-Sized T-Lymphocyte", "d": []}, {"i": "NCIT:C39600", "l": "Neoplastic Medium-Sized T-Lymphocyte", "d": []}]}
{"type": "biolink:Cell", "ic": "88.140761698499901", "identifiers": [{"i": "UMLS:C1708887", "l": "Malignant Large Squamous Cell", "d": []}, {"i": "NCIT:C54235", "l": "Malignant Large Squamous Cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5177615", "l": "Platelets | Blood | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "ic": "66.748105804263417", "identifiers": [{"i": "CL:0002681", "l": "kidney cortical cell", "d": []}]}
{"type": "biolink:Cell", "ic": "75.58416670140862", "identifiers": [{"i": "UMLS:C1706725", "l": "Adrenal Cortical Cell", "d": []}, {"i": "NCIT:C48358", "l": "Adrenal Cortical Cell", "d": ["An endocrine glandular cell located on the surface of the adrenal gland (adrenal cortex). It is responsible for the synthesis of glucocorticoids, aldosterone, and androgens."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5167383", "l": "Histiocytes | Blood | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0314584", "l": "Blast colony-forming unit", "d": []}, {"i": "SNOMEDCT:445113006", "d": []}]}
{"type": "biolink:Cell", "ic": "90.82444074280258", "identifiers": [{"i": "CL:0002182", "l": "surface mucosal cell of stomach", "d": ["A simple columnar cell that populates the entire luminal surface including the gastric pits. This cell types secrete mucus to form a thick protective, lubricant layer over the gastric wall."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1183931", "l": "Basal cell of prostatic acinus", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5163713", "l": "Erythrocytes | Cerebral spinal fluid | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "ic": "92.728541327098611", "identifiers": [{"i": "UMLS:C1708692", "l": "Leukemic Mast Cell", "d": []}, {"i": "NCIT:C43274", "l": "Leukemic Mast Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C4331503", "l": "Virus-specific Cytotoxic T-lymphocytes", "d": []}, {"i": "NCIT:C131870", "l": "Virus-specific Cytotoxic T-lymphocytes", "d": ["A population of cytotoxic T-lymphocytes (CTLs) specifically reactive to one or more pre-selected viruses, with potential antiviral activity. Upon infusion, after an allogeneic hematopoietic cell transplant (HCT) or in other immunodeficient states, these CTLs help reconstitute viral-specific CTL responses and kill virally infected cells, thereby inhibiting viral infection in immunocompromised patients."]}]}
{"type": "biolink:Cell", "ic": "68.203304431560539", "identifiers": [{"i": "CL:2000019", "l": "compound eye photoreceptor cell", "d": ["Any photoreceptor cell that is part of a compound eye."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:4028006", "l": "alveolar type 2 fibroblast cell", "d": ["A pulmonary interstitial fibroblast that is part of the alveolus and localizes to vascular adventitia."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C3496151", "l": "A6 noradrenaline cells", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0009063", "l": "enteroendocrine cell of anorectum", "d": ["An enteroendocrine cell that is located in the anorectum."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1441140", "l": "Reticulocytes.aggregate", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1440249", "l": "Cells.CD12", "d": []}]}
{"type": "biolink:Cell", "ic": "70.595126831462238", "identifiers": [{"i": "UMLS:C0225338", "l": "Columnar epithelial cell", "d": []}, {"i": "NCIT:C13158", "l": "Columnar Cell", "d": ["An epithelial cell that is taller than it is wide. The nucleus is oval, usually situated at the base of the cell. These cells line large glands and ducts."]}, {"i": "SNOMEDCT:6032003", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0229543", "l": "Pituitary hypertrophic amphophil cell", "d": []}, {"i": "SNOMEDCT:63926000", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:4030030", "l": "peripheral blood lymphocyte", "d": ["A blood lymphocyte located in the flowing, circulating blood of the body."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5171723", "l": "Lymphocytes/100 cells | Bone marrow | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1441343", "l": "100 lymphocytes", "d": []}]}
{"type": "biolink:Cell", "ic": "92.728541327098611", "identifiers": [{"i": "UMLS:C0206511", "l": "Hair Cells, Vestibular", "d": []}, {"i": "NCIT:C12632", "l": "Vestibular Hair Cell", "d": ["A sensory receptor cell, located within the vestibular system, that detects and transduces head movements into neural impulses that are transmitted by vestibular afferent nerves to the brain."]}, {"i": "MESH:D018069", "l": "Hair Cells, Vestibular", "d": []}]}
{"type": "biolink:Cell", "ic": "92.728541327098611", "identifiers": [{"i": "CL:1000490", "l": "mesothelial cell of peritoneum", "d": ["A mesothelial cell that is part of the peritoneum."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0001073", "l": "CD34-negative, CD56-positive, CD117-positive innate lymphoid cell, human", "d": ["An innate lymphoid cell in the human with the phenotype CD34-negative, CD56-positive, CD117-positive.Thie cell type may include precusors to NK cells and ILC3 cells."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5171866", "l": "Macrophages | Fetus | Pleural fluid | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "ic": "92.728541327098611", "identifiers": [{"i": "CL:0000373", "l": "histoblast", "d": ["A progenitor cell found in the larval epidermis of insects and that gives rise to the adult abdominal epidermis."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C4764288", "l": "Anti-EGFR CAR-transduced IL-12-expressing T-lymphocytes", "d": []}, {"i": "NCIT:C158602", "l": "Anti-EGFR CAR-transduced IL-12-expressing T-lymphocytes", "d": ["A preparation of human T-lymphocytes transduced with a retroviral vector encoding an anti-epidermal growth factor receptor (EGFR) chimeric antigen receptor (CAR) gene coupled to the signaling domains from CD28, 4-1BB (CD137) and CD3 zeta, and modified to express the cytokine interleukin-12 (IL-12), with potential immunostimulatory and antineoplastic activities. Upon administration, the anti-EGFR CAR-transduced IL-12-expressing T-lymphocytes target and bind to the EGFR antigen on tumor cell surfaces; subsequently, EGFR-expressing tumor cells may be lysed. IL-12 expression activates the immune system by promoting the secretion of interferon-gamma (IFNg), activating natural killer cells (NKs), and inducing cytotoxic T-cell responses, which may result in both decreased cell proliferation and increased cell death for the EGFR-overexpressing tumor cells. EGFR, overexpressed by a variety of cancer cell types, plays a key role in tumor cell proliferation, tumor angiogenesis and radio- and chemoresistance."]}]}
{"type": "biolink:Cell", "ic": "77.712653754434029", "identifiers": [{"i": "CL:4023013", "l": "corticothalamic-projecting glutamatergic cortical neuron", "d": ["A glutamatergic neuron located in the cerebral cortex that projects to the thalamus."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1955875", "l": "F9 Teratocarcinoma Stem Cells", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2324104", "l": "Diffuse cone bipolar cell", "d": []}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "UMLS:C1519373", "l": "Goblet cell of small intestine", "d": []}, {"i": "NCIT:C33567", "l": "Small Intestinal Goblet Cell", "d": ["A unicellular mucous cell found in the epithelium of the small intestine. Droplets of mucigen collect in the upper part of the cell and distend it, while the basal end remains slender, and the cell assumes the shape of a goblet."]}]}
{"type": "biolink:Cell", "ic": "88.140761698499901", "identifiers": [{"i": "UMLS:C1520156", "l": "Wisconsin ES Cell Line", "d": []}, {"i": "NCIT:C20307", "l": "Wisconsin ES Cell Line", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1182617", "l": "External epithelial cell of tympanic membrane", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5398046", "l": "brexucabtagene autoleucel", "d": []}, {"i": "MESH:C000705347", "l": "brexucabtagene autoleucel", "d": []}, {"i": "SNOMEDCT:895363000", "d": []}, {"i": "SNOMEDCT:895369001", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C3496353", "l": "C1 adrenaline cells", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0009046", "l": "T cell of medullary sinus of lymph node", "d": ["A T cell found in the lymph node medullary sinus."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5154476", "l": "Basophils | Body fluid | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1183361", "l": "Type-5 epithelial cell of thymus", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1317735", "l": "Agglutinated spermatozoa", "d": []}, {"i": "SNOMEDCT:726593007", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "MESH:D052940", "l": "Merozoites", "d": []}]}
{"type": "biolink:Cell", "ic": "53.464393125787396", "identifiers": [{"i": "CL:0002139", "l": "endothelial cell of vascular tree", "d": ["An endothelial cell of the vascular tree, which includes blood vessels and lymphatic vessels."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0598090", "l": "permanent cell line", "d": []}]}
{"type": "biolink:Cell", "ic": "92.728541327098611", "identifiers": [{"i": "CL:0009016", "l": "intestinal crypt stem cell of large intestine", "d": ["An intestinal stem cell that is located in the large intestine crypt of Liberkuhn. These stem cells reside at the bottom of crypts in the large intestine and are highly proliferative. They either differentiate into transit amplifying cells or self-renew to form new stem cells."]}]}
{"type": "biolink:Cell", "ic": "68.949061832187297", "identifiers": [{"i": "UMLS:C1514994", "l": "Striated muscle cell", "d": []}, {"i": "NCIT:C33637", "l": "Striated Muscle Cell", "d": ["A cylindrical multinucleated cell containing contracting myofibrils, across which run transverse light and dark areas, enclosed in a delicate plasma membrane."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:4030041", "l": "luminal endometrial ciliated epithelial cell", "d": ["A ciliated cell of the endometrial luminal epithelium."]}]}
{"type": "biolink:Cell", "ic": "83.023198044254755", "identifiers": [{"i": "UMLS:C1519090", "l": "Pinealocyte", "d": []}, {"i": "NCIT:C33323", "l": "Pineocyte", "d": ["A cell of the pineal body with long processes ending in bulbous expansions. Pineocytes receive a direct innervation from sympathetic neurons that form recognizable synapses. The club-shaped endings of pineocyte processes terminate in perivascular spaces surrounding capillaries."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1440393", "l": "Myeloperoxidase cells", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:4033027", "l": "diffuse bipolar 1 cell", "d": ["An OFF diffuse bipolar cell that makes synaptic contact with both L/M and S-cone photoreceptors and only minimal contact with rod photoreceptors."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5707881", "l": "Donislecel", "d": []}, {"i": "NCIT:C188575", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C4733622", "l": "Plasmodium vivax-infected Red Blood Cell", "d": []}, {"i": "NCIT:C155655", "l": "Plasmodium vivax-infected Red Blood Cell", "d": ["A preparation of red blood cells (RBCs) that have been infected with the malaria parasite Plasmodium vivax (P. vivax), with potential immunomodulating and antineoplastic activities. Upon administration of the P. vivax-infected RBCs, the P. vivax infection stimulates host immune responses against the P. vivax-infected RBCs. This also stimulates both innate and adaptive anti-tumor immune responses. This leads to the production of cytokines, including interferon-gamma (IFN-g) and tumor-necrosis factor alpha (TNF-a), the proliferation and activation of natural killer (NK) cells, dendritic cells (DCs), CD4-positive T-lymphocytes, and cytotoxic T-lymphocytes (CTLs). This results in the inhibition of tumor cell proliferation, induction of tumor cell apoptosis, and prevents angiogenesis."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0000984", "l": "IgA plasmablast", "d": ["A plasmablast that secretes IgA."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157673", "l": "CD8+HLA-DR+ cells | Blood | Cell markers", "d": []}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "CL:0000247", "l": "Rohon-Beard neuron", "d": ["Type of neuron that is a primary mechanosensory cell, with peripheral neurites innervating the skin with free nerve endings."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4304488", "l": "Population of all hypersegmented neutrophils in portion of fluid", "d": []}, {"i": "SNOMEDCT:719700004", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0524455", "l": "Structure of exocervical epithelial cell", "d": []}, {"i": "SNOMEDCT:91687006", "d": []}]}
{"type": "biolink:Cell", "ic": "26.93366367610999", "identifiers": [{"i": "CL:0000000", "l": "cell", "d": ["A material entity of anatomical origin (part of or deriving from an organism) that has as its parts a maximally connected cell compartment surrounded by a plasma membrane."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157356", "l": "CD19+CD38+ cells | Blood | Cell markers", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5706400", "l": "Autologous HBV-specific TCR-expressing T-lymphocytes SCG101", "d": []}, {"i": "NCIT:C187331", "l": "Autologous HBV-specific TCR-expressing T-lymphocytes SCG101", "d": ["A preparation of human autologous T-lymphocytes transduced with a retroviral vector encoding for a T-cell receptor (TCR) specific for HLA-A*02-restricted human hepatitis B virus (HBV) surface antigen (HBsAg) peptide, with potential antineoplastic activity. Upon administration, the autologous HBV-specific TCR-expressing T-lymphocytes SCG101 recognize and bind to HBV antigen-positive cells, which induces cytotoxic T-lymphocyte (CTL)-mediated elimination of HBV antigen-positive cells, including those in HBV-related hepatocellular carcinoma (HCC)."]}]}
{"type": "biolink:Cell", "ic": "78.96520244130248", "identifiers": [{"i": "CL:0002672", "l": "retinal progenitor cell", "d": ["A multi-fate stem cell that can give rise to different retinal cell types including rod and cone cells."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0003050", "l": "S cone cell", "d": ["A cone cell that detects short wavelength light. Exact peak of spectra detected differs between species. In humans, spectra peaks at 420-440 nm."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0000073", "l": "barrier epithelial cell", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0003023", "l": "retinal ganglion cell C6", "d": ["A retinal ganglion cell C outer that has dense dendritic diversity."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C3828683", "l": "Ovapuldencel-T", "d": []}, {"i": "NCIT:C113651", "l": "Ovapuldencel-T", "d": ["A cancer vaccine consisting of autologous dendritic cells (DCs) loaded with autologous, lethally irradiated cancer cells and mixed with the cytokine granulocyte-macrophage colony stimulating factor (GM-CSF), with potential immunostimulatory and antineoplastic activities. Upon vaccination, ovapuldencel-T may stimulate the immune system to exert a cytotoxic T-lymphocyte (CTL) immune response against the repertoire of tumor associated antigens (TAAs) found in the irradiated cancer cells. GM-CSF enhances the activation of dendritic cells (DCs) and promotes antigen presentation to both B- and T-lymphocytes."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C3826391", "l": "Erythrocyte disorders", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1511119", "l": "Binucleated Reed-Sternberg Cell", "d": []}, {"i": "NCIT:C37022", "l": "Binucleated Reed-Sternberg Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "90.82444074280258", "identifiers": [{"i": "CL:0002326", "l": "luminal epithelial cell of mammary gland", "d": ["A mammary epithelial cell that occurs in the lumen of the ductal and alveoli structure in the breast."]}]}
{"type": "biolink:Cell", "ic": "66.367368887635308", "identifiers": [{"i": "UMLS:C0007600", "l": "Cultured Cell Line", "d": []}, {"i": "NCIT:C16403", "l": "Cell Line", "d": ["A permanently established cell culture that will proliferate indefinitely given appropriate fresh medium and space."]}, {"i": "MESH:D002460", "l": "Cell Line", "d": []}]}
{"type": "biolink:Cell", "ic": "76.281523396999802", "identifiers": [{"i": "CL:0002174", "l": "follicular cell of ovary", "d": ["A cell within the follicle of an ovary."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5216302", "l": "Nucleated cells|NCnc|Pt|Periton fld", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157466", "l": "CD3+HLA-DR+ cells | Body fluid | Cell markers", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5163543", "l": "Epithelial cells | Urine sediment | Urinalysis", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5177457", "l": "Plasma cells immature | Blood | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "CL:0001018", "l": "immature CD8_alpha-low Langerhans cell", "d": ["Immature CD8_alpha-low Langerhans cell is a CD8_alpha-low Langerhans cell that is CD80-low, CD86-low, and MHCII-low."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5237220", "l": "Allogeneic CRISPR-Cas9 Engineered Anti-CD19 CAR T Cells CTX110", "d": []}, {"i": "NCIT:C165492", "l": "Allogeneic CRISPR-Cas9 Engineered Anti-CD19 CAR T Cells CTX110", "d": ["A preparation of human allogeneic T-lymphocytes transduced with a chimeric antigen receptor (CAR) specific for the tumor-associated antigen (TAA) CD19 and gene-edited with the clustered regularly interspaced short palindromic repeats (CRISPR)-Cas9 nuclease complex to eliminate endogenous TCR, with potential immunostimulating and antineoplastic activities. Upon introduction into the patient, the allogeneic CRISPR-Cas9 engineered anti-CD19 CAR T-cells CTX110 recognize and bind to CD19-overexpressing tumor cells. This may result in a specific cytotoxic T-lymphocyte (CTL)-mediated killing of CD19-positive tumor cells. Removal of endogenous TCR reduces the risk of graft-versus-host disease (GvHD). CD19 antigen is a B-cell specific cell surface antigen expressed in all B-cell lineage malignancies."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5706376", "l": "Anti-CD19/Anti-CD20/Anti-CD22 CAR-T Cells LCAR-AIO", "d": []}, {"i": "NCIT:C187129", "l": "Anti-CD19/Anti-CD20/Anti-CD22 CAR-T Cells LCAR-AIO", "d": ["A preparation of human T-lymphocytes that have been genetically modified and transduced with a lentiviral vector expressing a chimeric antigen receptor (CAR) targeting the tumor-associated antigens (TAAs) cluster of differentiation 19 (CD19), CD20 and CD22, with potential immunostimulating and antineoplastic activities. Upon administration, the anti-CD19/anti-CD20/anti-CD22 CAR-T cells LCAR-AIO target and bind to CD19, CD20 and CD22 expressed on the surface of certain tumor cells. This induces selective toxicity in tumor cells expressing these TAAs. The TAAs are overexpressed in certain hematologic malignancies."]}]}
{"type": "biolink:Cell", "ic": "88.140761698499901", "identifiers": [{"i": "CL:0002004", "l": "CD34-negative, GlyA-negative proerythroblast", "d": ["A proerythoblast that is CD34-negative and GlyA-negative."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1182614", "l": "Epithelial cell of external acoustic meatus", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5203928", "l": "Autologous HER2-CAR-modified Adenovirus-specific Cytotoxic T-lymphocytes", "d": []}, {"i": "NCIT:C158744", "l": "Autologous HER2-CAR-modified Adenovirus-specific Cytotoxic T-lymphocytes", "d": ["A population of autologous cytotoxic T-lymphocytes (CTLs) specifically reactive to human adenovirus (Ad) that have been transduced with a retroviral vector expressing a second-generation human epidermal growth factor receptor type 2 (HER2; EGFR2; ErbB2)-specific chimeric antigen receptor (CAR) comprised of an exodomain based on a anti-CD22 single chain variable fragment (scFv) from the anti-HER2 monoclonal antibody FRP5 that is linked to the costimulatory domains of CD28 and the zeta chain of the TCR/CD3 complex (CD3zeta), with potential immunostimulating and antineoplastic activities. Upon intravenous administration, the autologous HER2-CAR-modified Ad-specific CTLs are directed to and induce selective toxicity in HER2-expressing tumor cells. Additionally, these cells may help reconstitute Ad-specific CTL responses in immunocompromised individuals and others at risk of developing Ad-infection. HER2, a receptor tyrosine kinase (RTK) overexpressed by a variety of tumor cell types, belongs to the EGFR superfamily and plays a key role in tumor cell proliferation."]}]}
{"type": "biolink:Cell", "ic": "88.140761698499901", "identifiers": [{"i": "CL:0002224", "l": "lens epithelial cell", "d": ["A cell of the cuboidal epithelium that covers the lens. The cells of the lens epithelium regulate most of the homeostatic functions of the lens. As ions, nutrients, and liquid enter the lens from the aqueous humor, Na+/K+ ATPase pumps in the lens epithelial cells pump ions out of the lens to maintain appropriate lens osmolarity and volume, with equatorially positioned lens epithelium cells contributing most to this current. The activity of the Na+/K+ ATPases keeps water and current flowing through the lens from the poles and exiting through the equatorial regions. The cells of the lens epithelium also serve as the progenitors for new lens fibers. It constantly lays down fibers in the embryo, fetus, infant, and adult, and continues to lay down fibers for lifelong growth."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2334994", "l": "Brush cell of epithelium of trachea", "d": []}]}
{"type": "biolink:Cell", "ic": "84.75972595860604", "identifiers": [{"i": "CL:0000437", "l": "gonadtroph", "d": ["A rounded cell that is usually situated next to sinusoids; secretes follicular stimulating hormone (FSH) and luteinizing hormone (LH)."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5556517", "l": "atidarsagene autotemcel", "d": []}, {"i": "NCIT:C180638", "l": "Atidarsagene Autotemcel", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2333134", "l": "Neuron of cerebral cortex", "d": []}]}
{"type": "biolink:Cell", "ic": "81.247621244257502", "identifiers": [{"i": "CL:0002148", "l": "dental pulp cell", "d": ["A cell found within the dental pulp."]}]}
{"type": "biolink:Cell", "ic": "81.247621244257502", "identifiers": [{"i": "CL:0001204", "l": "CD4-positive, alpha-beta memory T cell, CD45RO-positive", "d": ["CD4-positive, alpha-beta long-lived T cell with the phenotype CD45RO-positive and CD127-positive. This cell type is also described as being CD25-negative, CD44-high, and CD122-high."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0000102", "l": "polymodal neuron", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1267915", "l": "Lymphocyte positive for CD38 antigen", "d": []}, {"i": "SNOMEDCT:116845004", "d": []}]}
{"type": "biolink:Cell", "ic": "92.728541327098611", "identifiers": [{"i": "UMLS:C0949666", "l": "Oxyphil Cells", "d": []}, {"i": "NCIT:C12654", "l": "Oxyphil Cell", "d": ["A glandular cell with acidophilic cytoplasm that contains tightly packed mitochondria. Oxyphil cells are found in the thyroid gland (Hurthle cells) and parathyroid gland."]}, {"i": "MESH:D024862", "l": "Oxyphil Cells", "d": []}]}
{"type": "biolink:Cell", "ic": "80.869303025598512", "identifiers": [{"i": "CL:0002430", "l": "CD4-intermediate, CD8-positive double-positive thymocyte", "d": ["A double-positive thymocyte that is undergoing positive selection, has high expression of the alpha-beta T cell receptor, is CD69-positive, and is in the process of down regulating the CD4 co-receptor."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5172364", "l": "Megaloblasts | Blood | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "ic": "71.693743768401106", "identifiers": [{"i": "CL:0000424", "l": "excretory cell", "d": ["A cell involved in the elimination of metabolic and foreign toxins, and in maintaining the ionic, acid-base and water balance of biological fluids."]}]}
{"type": "biolink:Cell", "ic": "78.96520244130248", "identifiers": [{"i": "CL:0000639", "l": "basophil cell of pars distalis of adenohypophysis", "d": ["A basophilic chromophil cell that of the anterior pituitary gland."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4267786", "l": "Cells.CD27-CD45RA+", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5400079", "l": "Adult human mesenchymal stem cells", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5421200", "l": "Prademagene Zamikeracel", "d": []}, {"i": "NCIT:C175196", "l": "Prademagene Zamikeracel", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:1001592", "l": "gallbladder glandular cell", "d": ["Glandular cell of gallbladder epithelium."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1512134", "l": "ES05", "d": []}, {"i": "NCIT:C20253", "l": "ES05", "d": ["Provider: ES Cell International Pte Ltd., Melbourne, Australia. Information from provider and not independently verified by NIH: Undergoing characterization. This cell line meets the criteria for the use of human embryonic stem cells by federally funded researchers."]}]}
{"type": "biolink:Cell", "ic": "80.511444690059548", "identifiers": [{"i": "UMLS:C1710037", "l": "Sebocyte", "d": []}, {"i": "NCIT:C43337", "l": "Sebocyte", "d": ["An epithelial cell that produces sebum, a thick, semi-fluid substance composed of fat and epithelial debris from the cells of innermost layer of the epithelium."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5154299", "l": "Band form neutrophils | Cerebral spinal fluid | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0000659", "l": "eggshell secreting cell", "d": ["An extracellular matrix secreting cell that secretes eggshell."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157683", "l": "CD8-CD57+ cells | Blood | Cell markers", "d": []}]}
{"type": "biolink:Cell", "ic": "62.270092653552254", "identifiers": [{"i": "UMLS:C0596981", "l": "Muscle Cells", "d": []}, {"i": "NCIT:C12612", "l": "Muscle Cell", "d": ["A connective tissue cell with the ability to convert chemical energy into mechanical energy via a contractile apparatus. As part of the contractile apparatus, the proteins actin and myosin form parallel myofilaments. The interaction of actin and myosin mediates muscle cell contraction in response to stimulation of the excitable cell membrane."]}, {"i": "MESH:D032342", "l": "Muscle Cells", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1545485", "l": "Parabasal epithelial cell", "d": []}, {"i": "SNOMEDCT:725265002", "d": []}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "UMLS:C0015161", "l": "Eukaryotic Cells", "d": []}, {"i": "NCIT:C12596", "l": "Eukaryotic Cell", "d": ["A cell with a membrane-bound nucleus."]}, {"i": "MESH:D005057", "l": "Eukaryotic Cells", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C4725690", "l": "Autologous Anti-CD19 CAR-T Cells TBI-1501", "d": []}, {"i": "NCIT:C150377", "l": "Autologous Anti-CD19 CAR-T Cells TBI-1501", "d": ["Autologous T-lymphocytes that have been transduced, via a proprietary technology involving a recombinant human fibronectin fragment to enhance transduction efficiency, with a retroviral vector to express a chimeric antigen receptor (CAR) consisting of a single chain variable fragment (scFv) of anti-CD19 coupled to co-stimulatory molecules, with potential immunostimulating and antineoplastic activities. Upon transfusion, anti-CD19-CAR-expressing autologous T-lymphocytes TBI-1501 target and bind to CD19-expressing neoplastic B-cells. This results in a cytotoxic T-lymphocyte (CTL) response against CD19-expressing tumor cells, the release of cytotoxic molecules and the induction of tumor cell lysis. CD19, cluster of differentiation 19, is a B-cell-specific cell surface antigen overexpressed in B-cell lineage tumors. Incorporation of the costimulatory signaling domains increase proliferation and activation of T-cells."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5177455", "l": "Plasma cells | Bone marrow | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "ic": "88.140761698499901", "identifiers": [{"i": "CL:0000301", "l": "pole cell", "d": ["A primordial germ cell of insects. Such cells form at the posterior pole of the early embryo."]}]}
{"type": "biolink:Cell", "ic": "85.457082654197222", "identifiers": [{"i": "CL:0000735", "l": "lymph gland hemocyte", "d": ["A hemocyte that derives from the larval lymph gland."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1440253", "l": "Cells.CD126", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5687320", "l": "Population of all neutrophilic metamyelocytes in portion of fluid", "d": []}, {"i": "SNOMEDCT:1208766005", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002143", "l": "dark chief cell of parathyroid gland", "d": ["A chief cell that is smaller than light chief cells and has a smaller and darker nucleus and a finely granular cytoplasm with many granules."]}]}
{"type": "biolink:Cell", "ic": "50.582780042159627", "identifiers": [{"i": "UMLS:C1513997", "l": "Neoplastic Large Cell", "d": []}, {"i": "NCIT:C37162", "l": "Neoplastic Large Cell", "d": ["A neoplastic cell with abundant amount of cytoplasm and/or large nucleus."]}]}
{"type": "biolink:Cell", "ic": "73.239986017158159", "identifiers": [{"i": "UMLS:C1881538", "l": "Malignant Basaloid Cell", "d": []}, {"i": "NCIT:C62227", "l": "Malignant Basaloid Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0000383", "l": "nephrogenic mesenchyme stem cell", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C2986999", "l": "Allogeneic Renal Cell Carcinoma Vaccine MGN1601", "d": []}, {"i": "NCIT:C95213", "l": "Allogeneic Renal Cell Carcinoma Vaccine MGN1601", "d": ["A whole cell vaccine comprised of irradiated allogeneic renal cell carcinoma (RCC) with potential immunostimulating and antineoplastic activities. Allogeneic renal cell carcinoma vaccine MGN1601 contains two active ingredients: 1) genetically modified allogeneic RCC cells that are transiently transfected with four different MIDGE (Minimalistic Immunogenically Defined Gene Expression) vectors encoding IL-7, GM-CSF, CD80 and CD154 and 2) the synthetic DNA-based immunomodulator dSLIM-30L1, a TLR9 agonist.. Vaccination results in expression of IL-7, GM-CSF, CD80 and CD154, which all contribute to the activation or enhancement of immune responses. Furthermore, administration of this RCC vaccine may elicit a cytotoxic T lymphocyte (CTL) response against similar host tumor cells, resulting in decreased tumor growth. TLR9 is a member of the TLR family, which plays a fundamental role in pathogen recognition and activation of innate immunity."]}]}
{"type": "biolink:Cell", "ic": "71.602448984170266", "identifiers": [{"i": "UMLS:C3161470", "l": "Cartilage Cell", "d": []}, {"i": "NCIT:C48695", "l": "Cartilage Cell", "d": []}, {"i": "SNOMEDCT:86024004", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:2000007", "l": "articular chondrocyte of knee joint", "d": ["Chondrocyte forming the hyaline cartilage found in the knee joint."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1519122", "l": "SA03", "d": []}, {"i": "NCIT:C20266", "l": "SA03", "d": ["Provider: Goteborg University, Goteborg, Sweden. No information from provider. This cell line meets the criteria for the use of human embryonic stem cells by federally funded researchers."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157664", "l": "CD8 cells | Blood | Cell markers", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1180269", "l": "Myoepithelial cell of lactiferous gland", "d": []}]}
{"type": "biolink:Cell", "ic": "92.728541327098611", "identifiers": [{"i": "CL:1001131", "l": "vasa recta ascending limb cell", "d": ["A cell that is part of some vasa recta ascending limb."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5419877", "l": "Anti-CD7 CAR T-cells", "d": []}, {"i": "NCIT:C172817", "l": "Anti-CD7 CAR T-cells", "d": ["A preparation of T-lymphocytes that have been genetically engineered to express a chimeric antigen receptor (CAR) directed against the tumor-associated antigen (TAA) CD7, with potential immunostimulating and antineoplastic activities. Upon administration, the anti-CD7 CAR T-cells specifically recognize and bind to CD7-expressing tumor cells, resulting in specific T-cell-mediated tumor cell lysis. CD7 is a transmembrane glycoprotein expressed by T-cells and natural killer (NK) cells and their precursors. It is expressed in the majority of lymphoblastic T-cell leukemias and lymphomas and in a subset of peripheral T-cell lymphomas."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:1000418", "l": "myoepithelial cell of lactiferous alveolus", "d": ["A myoepithelial cell that is part of the mammary gland alveolus."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0004222", "l": "flag B amacrine cell", "d": ["A flag amacrine cell with post-synaptic terminals in S3, S4, and S5. This cell type releases the neurotransmitter glycine."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0003010", "l": "G7 retinal ganglion cell", "d": ["A bistratified retinal ganglion cell that has a dendrite field that terminates in sublaminar layer S2 and a second dendrite field that terminates in sublaminar layer S4."]}]}
{"type": "biolink:Cell", "ic": "54.292428664866257", "identifiers": [{"i": "UMLS:C0085133", "l": "Reed-Sternberg Cells", "d": []}, {"i": "NCIT:C12660", "l": "Reed-Sternberg Cell", "d": []}, {"i": "MESH:D016539", "l": "Reed-Sternberg Cells", "d": []}, {"i": "SNOMEDCT:32915009", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4322737", "l": "CD1+ T lymphocyte", "d": []}]}
{"type": "biolink:Cell", "ic": "67.06015934163878", "identifiers": [{"i": "CL:0002563", "l": "intestinal epithelial cell", "d": ["An epithelial cell of the intestine."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5557201", "l": "NY-ESO-1-expressing Artificial Adjuvant Vector Cells ASP0739", "d": []}, {"i": "NCIT:C181663", "l": "NY-ESO-1-expressing Artificial Adjuvant Vector Cells ASP0739", "d": ["A preparation of artificial adjuvant vector cells (aAVCs) composed of modified human cells engineered to express the tumor-associated antigen (TAA) New York esophageal squamous cell carcinoma 1 (NY-ESO-1) and loaded with loaded with the cluster of differentiation 1d (CD1d) ligand alpha-galactosylceramide (alpha-GalCer; a-GalCer), with potential immunostimulating and antineoplastic activities. Upon administration of the NY-ESO-1-expressing aAVCs ASP0739, the presentation of α-GalCer by CD1d molecules on the cell surface activates invariant NKT (iNKT) cells\" activates invariant NKT (iNKT) cells, thereby eliciting NY-ESO-1-specific NKT cell responses against ASP0739. This in turn activates a natural killer (NK) cell response against NY-ESO-1-expressing tumor cells. In turn, the NY-ESO-1 released from destroyed ASP0739 is taken up by antigen-presenting cells (APCs), mainly by dendritic cells (DCs), which in turn activates NY-ESO-1-specific cytotoxic T-lymphocytes (CTL) and results in a CTL-mediated immune response against NY-ESO-1-expressing tumor cells, thereby further destroying NY-ESO-1-expressing tumor cells. In addition, the activation of antigen-specific memory T cells provides long-lasting anti-tumor effects against the NY-ESO-1-expressing tumor cells."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5761822", "l": "Allogeneic anti-CD20 CAR T cells", "d": []}]}
{"type": "biolink:Cell", "ic": "81.648881485605159", "identifiers": [{"i": "CL:0002074", "l": "myocardial endocrine cell", "d": ["The myoendocrine cellis a specialized myocyte localized mainly in the right and left atrial appendages, and also scattered within other areas of the atria and along the conductive system in the ventricular septum. The most conspicuous feature distinguishing myoendocrine cells from other atrial myoctyes is the presence of membane-bounded secretory granules (these granules contain precursor of cardiodilatins or atrial natriuretic polypeptides)."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:4033044", "l": "deuterosomal cell", "d": ["An epithelial cell part of respiratory tract epithelium that is a precursor of a multi-ciliated cell. This cell actively amplifies centrioles, a required step for multiciliogenesis."]}]}
{"type": "biolink:Cell", "ic": "88.140761698499901", "identifiers": [{"i": "CL:0001030", "l": "CD117-positive common myeloid progenitor OR CD217-positive common lymphoid progenitor", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C3899817", "l": "CD19CAR-CD3zeta-4-1BB-CD28-expressing Autologous T-Lymphocytes", "d": []}, {"i": "NCIT:C116069", "l": "CD19CAR-CD3zeta-4-1BB-CD28-expressing Autologous T-Lymphocytes", "d": ["Autologous T-lymphocytes transduced with a retroviral vector expressing a chimeric antigen receptor (CAR) consisting of an anti-CD19 scFv (single chain variable fragment) coupled to three co-stimulatory signaling domains derived from CD28, 4-1BB (CD137), and the zeta chain of the T-cell receptor (TCR)/CD3 complex (CD3-zeta), with potential immunomodulating and antineoplastic activities. Upon transfusion, the CD19CAR-CD3zeta-4-1BB-CD28-expressing autologous T-lymphocytes direct the T-lymphocytes to CD19-expressing tumor cells and induce their selective toxicity. CD28, a T-cell surface-associated co-stimulatory molecule, is required for T-cell activation, proliferation, and survival. The 4-1BB co-stimulatory molecule signaling domain enhances activation and signaling after recognition of CD19. CD3-zeta is a transmembrane signaling adaptor polypeptide that regulates the assembly of TCR complexes, modulates the expression of the complex on the cell surface and plays a key role in antigen recognition. CD19 antigen, a B-cell specific cell surface antigen, is expressed in all B-cell lineage malignancies."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C4316814", "l": "Pelger Huet cell -- cell", "d": []}, {"i": "NCIT:C36721", "l": "Pelger-Huet Cell", "d": []}, {"i": "SNOMEDCT:726587004", "d": []}]}
{"type": "biolink:Cell", "ic": "75.751739371353352", "identifiers": [{"i": "UMLS:C0018183", "l": "granulocyte", "d": []}, {"i": "NCIT:C12530", "l": "Granulocyte", "d": ["A type of leukocyte with a multilobed nucleus and cytoplasmic granules. The unique morphology of the nucleus has led to their also being known as polymorphonuclear leukocytes (PMLs or PMNs). Granulocytes are subdivided according to the staining properties of their granules into eosinophils (red with acidic dye), basophils (blue with basic dye), and neutrophils (not amenable to staining with either acidic or basic dyes)."]}, {"i": "MESH:D006098", "l": "Granulocytes", "d": []}, {"i": "SNOMEDCT:48791004", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4267783", "l": "Cells.CD4-CD8-", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157504", "l": "CD36 blasts | Blood | Cell markers", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0545579", "l": "Marrow proplasmacyte", "d": []}]}
{"type": "biolink:Cell", "ic": "58.531431596370737", "identifiers": [{"i": "CL:0000413", "l": "haploid cell", "d": ["A cell whose nucleus contains a single haploid genome."]}]}
{"type": "biolink:Cell", "ic": "57.67125409686885", "identifiers": [{"i": "UMLS:C1512631", "l": "Immature B-Lymphocyte", "d": []}, {"i": "NCIT:C32766", "l": "Immature B-Lymphocyte", "d": ["A B-lymphocyte derived from a Pre B lymphocyte. It develops in bone marrow then exit via the central sinus. It goes through the vascular system to the spleen. It does not proliferate and differentiate in response to antigen, but instead responds to antigen by negative selection resulting in subsequent immune system tolerance to that antigen."]}, {"i": "MESH:D054448", "l": "Precursor Cells, B-Lymphoid", "d": []}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "CL:0000615", "l": "basidiospore", "d": ["A thick walled spore containing one or more haploid nuclei produced by sexual reproduction in an Basidiomycete; formed externally on extrusions of the basidium."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1441345", "l": "100 spermatozoa", "d": []}]}
{"type": "biolink:Cell", "ic": "92.728541327098611", "identifiers": [{"i": "CL:1001068", "l": "kidney venous system smooth muscle cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5148041", "l": "CD55 Monocytes", "d": []}]}
{"type": "biolink:Cell", "ic": "57.749057458637679", "identifiers": [{"i": "CL:0000327", "l": "extracellular matrix secreting cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C3849994", "l": "Ia Inhibitory Interneurons", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002426", "l": "CD11b-positive, CD27-positive natural killer cell, mouse", "d": ["A mature natural killer cell that is CD11b-positive and CD27-positive."]}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "CL:0002410", "l": "pancreatic stellate cell", "d": ["A cell that is found in the periacinar space of the exocrine pancreas and in perivascular and periductal regions of the pancreas, and has long cytoplasmic processes that encircle the base of the acinus. Expresses several intermediate filament proteins including vimentin and nestin. Shares many of the characteristics of hepatatic stellate cells, but not stellate cells of the central nervous system. Upon activation, this cell type undergoes morphological and gene expression changes that make the cell suggestive of being a type of myofibroblast."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157525", "l": "CD3-CD56+ cells | Blood | Cell markers", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C4744702", "l": "Autologous Anti-CD19 CAR TCR-zeta/4-1BB-transduced T-lymphocytes huCART19", "d": []}, {"i": "NCIT:C156271", "l": "Autologous Anti-CD19 CAR TCR-zeta/4-1BB-transduced T-lymphocytes huCART19", "d": ["Autologous T-lymphocytes that have been transduced with a lentiviral vector to express a chimeric antigen receptor (CAR) consisting of a humanized single chain variable fragment (scFv) of anti-CD19 coupled to the cytoplasmic portion of the zeta chain of the human T-cell receptor (CD3zeta) and the co-stimulatory molecule 4-1BB (CD137), with potential immunostimulating and antineoplastic activities. Upon re-introduction into the patient, the autologous anti-CD19 CAR TCR-zeta/4-1BB-transduced T-lymphocytes huCART19 target and bind to CD19-expressing neoplastic B-cells. This results in a cytotoxic T-lymphocyte (CTL) response against CD19-expressing tumor cells, resulting in tumor cell lysis. CD19 (cluster of differentiation 19) is a B-cell-specific cell surface antigen overexpressed in B-cell lineage tumors. Incorporation of the co-stimulatory signaling domains increases human T-cell function, expansion, and survival."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1182606", "l": "Granular cell of epidermis", "d": []}]}
{"type": "biolink:Cell", "ic": "78.695011174409487", "identifiers": [{"i": "CL:0000354", "l": "blastemal cell", "d": []}]}
{"type": "biolink:Cell", "ic": "92.728541327098611", "identifiers": [{"i": "CL:0002532", "l": "CD16-positive myeloid dendritic cell", "d": ["A myeloid dendritic cell found in the blood that is CD16-positive."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:2000069", "l": "gallbladder fibroblast", "d": ["Any fibroblast that is part of a gallbladder."]}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "CL:0000575", "l": "corneal epithelial cell", "d": ["An epithelial cell of the cornea."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5177776", "l": "Polyclonal plasma cells/Plasma cells.total | Bone marrow | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C4682857", "l": "BB 21217", "d": []}, {"i": "NCIT:C140310", "l": "Autologous Anti-BCMA-CAR-4-1BB-CD3zeta-expressing Memory T-lymphocytes bb21217", "d": ["A preparation of autologous memory T-lymphocytes transduced, ex vivo, with a lentiviral vector expressing a chimeric antigen receptor (CAR) containing an anti-B-cell maturation antigen (BCMA) single chain variable fragment (scFv) fused to the signaling domain of 4-1BB (CD137) and a CD3-zeta T-cell activation domain, with potential immunostimulating and antineoplastic activities. Upon intravenous administration back into the patient, the autologous anti-BCMA-CAR-4-1BB-CD3zeta-expressing memory T-lymphocytes bb21217 are directed to, and induce selective toxicity in, BCMA-expressing tumor cells. BCMA, a tumor specific antigen and a receptor for both a proliferation-inducing ligand (APRIL) and B-cell activating factor (BAFF), is a member of the tumor necrosis factor receptor superfamily (TNFRSF) and plays a key role in plasma survival. BCMA is overexpressed on malignant plasma cells."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1440231", "l": "Cell positive for BCL2 protein", "d": []}, {"i": "SNOMEDCT:725310003", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157442", "l": "CD3+CD4+CD27-CD45RO+CD62L- cells | Blood | Cell markers", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C4329371", "l": "Autologous Monocytes", "d": []}, {"i": "NCIT:C129877", "l": "Autologous Monocytes", "d": ["A preparation of autologous monocytes, with potential immunomodulating activity. Following isolation and administration, the autologous monocytes may differentiate into classic M1 macrophages, which are able to directly attack and kill tumor cells. The stimulated monocytes also promote natural killer (NK) cell differentiation, which further enhances tumor cell killing through NK-mediated cytotoxicity."]}]}
{"type": "biolink:Cell", "ic": "86.236661114203869", "identifiers": [{"i": "UMLS:C1710683", "l": "Wreath-Like Multinucleated Giant Cell", "d": []}, {"i": "NCIT:C53640", "l": "Wreath-Like Multinucleated Giant Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1517631", "l": "K-562", "d": []}, {"i": "NCIT:C19437", "l": "K-562", "d": ["The continuous cell line K-562 was established by Lozzio and Lozzio from the pleural effusion of a 53-year-old female with chronic myelogenous leukemia in terminal blast crises. The K562 line is composed of undifferentiated blast cells that are rich in glycophorin and may be induced to produce fetal and embryonic hemoglobin in the presence of hemin."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5163545", "l": "Epithelial cells | XXX | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1520131", "l": "Well Differentiated Adenocarcinoma Cell", "d": []}, {"i": "NCIT:C36796", "l": "Well Differentiated Adenocarcinoma Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1514024", "l": "Neoplastic Merkel Cell", "d": []}, {"i": "NCIT:C37098", "l": "Neoplastic Merkel Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0004001", "l": "local interneuron", "d": ["An interneuron whose axon stays entirely within the gray matter region where the cell body resides."]}]}
{"type": "biolink:Cell", "ic": "77.944915021140389", "identifiers": [{"i": "CL:1001598", "l": "small intestine glandular cell", "d": ["A glandular cell found in the epithelium of the small intestine. Example: Enterocytes, Goblet cells, enteroendocrine cells; Paneth cells; M cells; Somatostatin-secreting Cells (D-cells) ."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C2987399", "l": "Anti-CD3 x Anti-CD20 Bispecific Antibody-Armed Activated T Cells", "d": []}, {"i": "NCIT:C95751", "l": "Anti-CD3 x Anti-CD20 Bispecific Antibody-Armed Activated T Cells", "d": ["Autologous activated T cells that have been coated with bispecific antibodies (BiAb), with potential antineoplastic and immunomodulating activities. In vitro, T cells are activated through exposure to the anti-CD3 murine monoclonal antibody OKT3 and low-dose interleukin 2 (Il-2) for 6-14 days and then armed with anti-CD3 x anti-CD20 bispecific antibody (CD20Bi). Upon administration, anti-CD3 x anti-CD20 bispecific antibody-armed activated T cells (AATC) attach to CD3-expressing T cells and CD20-expressing tumor cells, selectively cross-linking T cells and tumor cells. This may result in the recruitment and activation of cytotoxic T lymphocyte (CTLs), CTL-mediated specific tumor cell lysis, and the secretion of antitumor cytokines and chemokines. CD20, a cell surface phosphoprotein, is found on normal B cells and most B-cell tumors."]}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "UMLS:C4055262", "l": "Central Memory Immune Cell", "d": []}, {"i": "NCIT:C122730", "l": "Central Memory Immune Cell", "d": ["A population of long-lived antigen-specific immune cells, usually T-lymphocytes expressing CD45RO, L-selectin and CCR7, that are maintained by the immune system. Upon subsequent exposure to their target antigen, these cells rapidly proliferate and differentiate into effector cells."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C3899843", "l": "C46/CCR5/P140K Lentiviral Vector-transduced Autologous HSPCs", "d": []}, {"i": "NCIT:C119735", "l": "C46/CCR5/P140K Lentiviral Vector-transduced Autologous HSPCs", "d": ["Autologous CD34-positive, hematopoietic stem progenitor cells (HSPCs) genetically modified with a lentiviral vector expressing short hairpin RNA that targets human chemokine receptor 5 (CCR5) mRNA (shCCR5), the HIV entry inhibitor C46, a membrane-anchored 46-amino acid sequence found in HIV-1 gp41, and the drug resistance gene P140K, a mutant form of the DNA repair protein O6-methylguanine-DNA methyltransferase (MGMT), used to potentially provide resistance against human immunodeficiency virus (HIV) infection. Human autologous CD34+ HSPCs are isolated and transduced ex vivo with the pRSC-H1.shCCR5.Ubic.C46.EF1alpha.P140K.wpre lentiviral vector. shCCR5 binds to CCR5 mRNA and inhibits the expression of CCR5, a HIV-1 co-receptor that mediates HIV attachment and cell entry. Additionally, the expression of C46 blocks HIV-1 fusion to the cellular membrane. Upon re-infusion into the HIV-infected lymphoma patient, the C46/shCCR5/P140K lentiviral vector-transduced autologous HSPCs are resistant to HIV entry, which protects these cells against HIV infection and replication, and increases the amount of HIV-resistant CD4+ T-cells. HIV-resistant HSPCs could provide long-term protection against latent HIV infection and against HIV-associated cancers. In addition, the formation of immune cells resistant to HIV may result in the destruction of HIV-infected cells. P140K expression facilitates the in vivo chemoselection of gene-modified HSPCs, using O6-benzylguanine (O6BG)/bis-chloroethylnitrosourea (BCNU/carmustine), which increases the proportion of these HIV resistant CD34+ cells. P140K also protects these stem cells from future destruction by certain chemotherapeutic agents; if cancer were to develop, P140K is not inactivated by the MGMT inhibitor O6BG."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1179503", "l": "Cementocyte", "d": []}, {"i": "NCIT:C32275", "l": "Cementocyte", "d": ["A cell in a hollow cavity of cellular cementum, ranging in shape from round to oval or flattened, and exhibiting numerous protoplasmic processes extending from its free surface."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0003003", "l": "G2 retinal ganglion cell", "d": ["A mono-stratified retinal ganglion cell that has a small dendritic field and a sparse dendritic arbor with post sympatic terminals in sublaminar layer S3."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C0206436", "l": "Photoreceptor Cells, Invertebrate", "d": []}, {"i": "NCIT:C12635", "l": "Photoreceptors, Invertebrate", "d": ["Specialized cells in invertebrate animals that convert light signals into nerve impulses."]}, {"i": "MESH:D017956", "l": "Photoreceptor Cells, Invertebrate", "d": []}]}
{"type": "biolink:Cell", "ic": "80.869303025598512", "identifiers": [{"i": "UMLS:C1513487", "l": "Monovacuolated Lipoblast", "d": []}, {"i": "NCIT:C36972", "l": "Monovacuolated Lipoblast", "d": []}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "CL:0002136", "l": "type II cell of adrenal cortex", "d": ["A cell in the zona fasciculata that produce glucocorticoids, e.g cortisol."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0005015", "l": "inner phalangeal cell", "d": ["An auditory epithelial support cell that surrounds the nerve fibers and synapses of the auditory inner hair cells."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0011011", "l": "intermediate mesodermal cell", "d": ["A cell derived from the mesoderm that is located between the paraxial mesoderm and the lateral plate."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0333833", "l": "Ragocyte", "d": []}, {"i": "SNOMEDCT:45417004", "d": []}]}
{"type": "biolink:Cell", "ic": "88.140761698499901", "identifiers": [{"i": "UMLS:C1512103", "l": "Dysplastic Ganglion Cell", "d": []}, {"i": "NCIT:C42085", "l": "Dysplastic Ganglion Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:1000342", "l": "enterocyte of epithelium proper of ileum", "d": ["An enterocyte that is part of the epithelium proper of ileum."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157384", "l": "CD20+FMC7+ cells | Bone marrow | Cell markers", "d": []}]}
{"type": "biolink:Cell", "ic": "87.120474278337809", "identifiers": [{"i": "CL:0000644", "l": "Bergmann glial cell", "d": ["Type of radial astrocyte in the cerebellar cortex that have their cell bodies in the Purkinje cell layer and processes that extend into the molecular layer, terminating with bulbous endfeet at the pial surface. Bergmann glia express high densities of glutamate transporters that limit diffusion of the neurotransmitter glutamate during its release from synaptic terminals. Besides their role in early development of the cerebellum, Bergmann glia are also required for the pruning or addition of synapses."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5219210", "l": "Neutrophils|NCnc|Urine", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:1000417", "l": "myoepithelial cell of sweat gland", "d": ["A myoepithelial cell that is part of the sweat gland."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1954324", "l": "Leukocytes+Platelets", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157410", "l": "CD25 cells | Blood | Cell markers", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:1000467", "l": "chromaffin cell of left ovary", "d": ["A chromaffin cell that is part of the left ovary."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157615", "l": "CD55+CD59 deficient RBC+Granulocytes | Blood | Cell markers", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002568", "l": "mesenchymal stem cell of Wharton's jelly", "d": ["A mesenchymal stem cell that is part of Wharton's jelly."]}]}
{"type": "biolink:Cell", "ic": "77.944915021140389", "identifiers": [{"i": "UMLS:C1518309", "l": "Neutrophil with Abnormal Cytoplasmic Granulation", "d": []}, {"i": "NCIT:C37173", "l": "Neutrophil with Abnormal Cytoplasmic Granulation", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1182636", "l": "Primary follicular cell of ovary", "d": []}]}
{"type": "biolink:Cell", "ic": "75.58416670140862", "identifiers": [{"i": "UMLS:C0228071", "l": "Ganglion cell", "d": []}, {"i": "NCIT:C13155", "l": "Ganglion Cell", "d": ["A type of interneuron that conveys information to the brain."]}, {"i": "SNOMEDCT:53102003", "d": []}]}
{"type": "biolink:Cell", "ic": "80.511444690059548", "identifiers": [{"i": "CL:0000545", "l": "T-helper 1 cell", "d": ["A CD4-positive, alpha-beta T cell that has the phenotype T-bet-positive, CXCR3-positive, CCR6-negative, and is capable of producing interferon-gamma."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1978611", "l": "Cells.CD3+CD8+CD57+", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5163539", "l": "Epithelial cells | Nose | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5160254", "l": "Clue cells | Vaginal | Microbiology", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0553711", "l": "Blood band cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1148324", "l": "Cells.CD20+CD25+", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:1000363", "l": "transitional myocyte of atrial branch of anterior internodal tract", "d": ["A transitional myocyte that is part of the atrial branch of anterior internodal tract."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4704951", "l": "Multipotent Mesenchymal Stromal Cells", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1440832", "l": "Islet cell 512", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002264", "l": "type A cell of stomach", "d": ["A type of enteroendocrine cell found in the stomach that secretes glucagon."]}]}
{"type": "biolink:Cell", "ic": "84.128890093485552", "identifiers": [{"i": "UMLS:C1513742", "l": "Multilobated Neoplastic B-Lymphocyte", "d": []}, {"i": "NCIT:C37169", "l": "Multilobated Neoplastic B-Lymphocyte", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5700397", "l": "Anti-CD19/CD28/zeta Modified CAR CD3+ T Lymphocytes JCAR015", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5148040", "l": "Monocytes.CD14", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0004231", "l": "recurving diffuse amacrine cell", "d": ["A broadly stratifying amacrine cell with a small dendritic field and a complex dendritic arbor. Recurving diffuse amacrine cells have post-synaptic terminals in S2, S3, and S4."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C3827836", "l": "TGFbDNRII-transduced Autologous Tumor Infiltrating Lymphocytes", "d": []}, {"i": "NCIT:C111992", "l": "TGFbDNRII-transduced Autologous Tumor Infiltrating Lymphocytes", "d": ["A preparation of tumor infiltrating lymphocytes (TILs) that are transduced with a retroviral vector encoding a gene for a dominant-negative form of the transforming growth factor beta (TGFb) receptor, TGFbDNRII, with potential immunomodulating activity. Upon administration, the TGFbDNRII-transduced autologous TILs recognize and kill tumor cells. The expression of TGFbDNRII allows for the TILs to be resistant to TGF-b-mediated inhibition of T cell proliferation and activation, which allows optimal TIL activity. The immunosuppressant TGF-b is produced by tumor cells and plays a key role in the repression of the immune system."]}]}
{"type": "biolink:Cell", "ic": "73.239986017158159", "identifiers": [{"i": "UMLS:C1882991", "l": "Secretory Adenocarcinoma Cell", "d": []}, {"i": "NCIT:C60313", "l": "Secretory Adenocarcinoma Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "UMLS:C1513975", "l": "Neoplastic Glandular Cell with Enlarged Nucleus", "d": []}, {"i": "NCIT:C37122", "l": "Neoplastic Glandular Cell with Enlarged Nucleus", "d": []}]}
{"type": "biolink:Cell", "ic": "70.290762085176738", "identifiers": [{"i": "UMLS:C1708904", "l": "Malignant Rhabdomyoblast", "d": []}, {"i": "NCIT:C49198", "l": "Malignant Rhabdomyoblast", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C3831510", "l": "Anti-VEGFR2-CAR Retroviral Vector-transduced Autologous T-lymphocytes", "d": []}, {"i": "NCIT:C111038", "l": "Anti-VEGFR2-CAR Retroviral Vector-transduced Autologous T-lymphocytes", "d": ["Autologous human CD8-positive T-lymphocytes transduced with a recombinant retroviral vector encoding a chimeric T cell receptor (chimeric antigen receptor or CAR) consisting of an anti-vascular endothelial growth factor receptor type 2 (VEGFR2) scFv (single chain variable fragment), linked to the transmembrane domain of human CD8alpha and coupled to the costimulatory signaling domains of both CD28 and 4-1BB (CD137), and the CD3 zeta chain of the T-cell receptor (TCR), with potential immunostimulating and antineoplastic activities. Autologous peripheral blood lymphocytes (PBLs) from a patient with VEGFR2-positive cancer are pulsed with a retroviral vector that encodes the CAR gene specific for VEGFR2. After expansion in culture and reintroduction into the patient, the anti-VEGFR2 CAR-gene engineered CD8+ lymphocytes express anti-VEGFR2-CAR on their cell surfaces and bind to the VEGFR2 antigen on tumor cell surfaces. Subsequently, VEGFR2-expressing tumor cells are lysed. VEGFR2, a receptor tyrosine kinase (RTK) overexpressed by a variety of cancer cell types, belongs to the VEGFR superfamily and plays key roles in tumor cell proliferation, survival, invasion and tumor angiogenesis. The co-stimulatory molecules are required for optimal T-cell activation."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5170935", "l": "Leukocytes | Pleural fluid | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5417959", "l": "Allogeneic CRISPR-Cas9 Engineered Anti-CD70 CAR-T Cells CTX130", "d": []}, {"i": "NCIT:C173153", "l": "Allogeneic CRISPR-Cas9 Engineered Anti-CD70 CAR-T Cells CTX130", "d": ["A preparation of human allogeneic T-lymphocytes gene-edited with the clustered regularly interspaced short palindromic repeats (CRISPR)-Cas9 nuclease complex to disrupt expression of endogenous TCR and major histocompatibility complex (MHC) class I molecules and modified to express a chimeric antigen receptor (CAR) specific for the tumor-associated antigen (TAA) human cluster of differentiation 70 (CD70), with potential immunostimulating and antineoplastic activities. Upon introduction into the patient, the allogeneic CRISPR-Cas9 engineered anti-CD70 CAR T-cells CTX130 recognize and bind to CD70-overexpressing tumor cells. This may result in a specific cytotoxic T-lymphocyte (CTL)-mediated killing of CD70-positive tumor cells. CD70, the ligand for the costimulatory receptor CD27 and a member of the tumor necrosis factor (TNF) family, is found on the surfaces of various types of cancer cells. Disruption of endogenous TCR prevents graft-versus-host disease (GvHD); the disruption of MHC class I molecules increases the persistence of the CAR T-cells."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002506", "l": "liver CD103-positive dendritic cell", "d": ["A CD11b-positive dendritic cell that is CD11b-low, CD45-positive, MHC-II-high and CD103-positive that is located in the liver."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5183793", "l": "Transitional cells | Urine sediment | Urinalysis", "d": []}]}
{"type": "biolink:Cell", "ic": "76.857431420584163", "identifiers": [{"i": "CL:0000541", "l": "melanoblast", "d": ["A cell that originates from the neural crest and differentiates into a pigment cell."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C3494452", "l": "Central Pattern Generator Neurons", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1512641", "l": "Immature Mesenchymal Spindle Cell", "d": []}, {"i": "NCIT:C37120", "l": "Immature Mesenchymal Spindle Cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0552337", "l": "bladder cells", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5216307", "l": "Platelets|NCnc|Pt|Bld", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0945930", "l": "Cells.CD4+CD45RA+", "d": []}]}
{"type": "biolink:Cell", "ic": "74.240948556675605", "identifiers": [{"i": "UMLS:C0596155", "l": "Basal Cell", "d": []}, {"i": "NCIT:C12475", "l": "Skin Basal Cell", "d": ["A cuboidal or low columnar cell in the deepest epidermal layer, stratum basale (stratum germinativum), adjacent to the basal lamina."]}]}
{"type": "biolink:Cell", "ic": "57.222714434846154", "identifiers": [{"i": "UMLS:C1514100", "l": "Neoplastic Spindle Cell", "d": []}, {"i": "NCIT:C36823", "l": "Neoplastic Spindle Cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4697018", "l": "Cells.CD21+", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5163750", "l": "Erythrocytes.fresh/100 erythrocytes | Cerebral spinal fluid | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0000915", "l": "CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell", "d": ["An alpha-beta intraepithelial T cell with the phenotype CD8-alpha-alpha-positive located in the columnar epithelium of the gastrointestinal tract. These cells have a memory phenotype of CD2-negative and CD5-negative."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C3178785", "l": "Adrenergic Neurons", "d": []}, {"i": "MESH:D059331", "l": "Adrenergic Neurons", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5401498", "l": "Human Umbilical Cord Mesenchymal Stem Cells", "d": []}]}
{"type": "biolink:Cell", "ic": "82.076046914303362", "identifiers": [{"i": "CL:0002042", "l": "immature NK T cell stage IV", "d": ["A CD24-low, CD44-positive, DX5-high, NK1.1-negative NK T cell."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157297", "l": "CD13 blasts | XXX | Cell markers", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4707434", "l": "Technetium (99m-Tc) exametazime labeled leukocytes", "d": []}, {"i": "SNOMEDCT:765339002", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5446902", "l": "Allogeneic Anti-CD30 CAR-Epstein-Barr Virus-specific T-lymphocytes", "d": []}, {"i": "NCIT:C175980", "l": "Allogeneic Anti-CD30 CAR-Epstein-Barr Virus-specific T-lymphocytes", "d": ["A preparation of allogeneic human Epstein-Barr virus (EBV)-specific T-lymphocytes (EBVSTs) that have been genetically modified to express a chimeric antigen receptor (CAR) recognizing the tumor-associated antigen (TAA) cluster of differentiation 30 (CD30), with potential immunostimulating and antineoplastic activities. Upon administration, allogeneic anti-CD30 CAR-EBVSTs specifically recognize and bind to CD30-expressing EBV-infected tumor cells, resulting in tumor cell lysis. CD30, a cell surface receptor and a member of the tumor necrosis factor (TNF) receptor superfamily, is transiently expressed on activated lymphocytes and is constitutively expressed in hematologic malignancies. EBV, a ubiquitous human herpes virus, is associated with various malignancies, including nasopharyngeal carcinoma, Hodgkin disease, non-Hodgkin lymphoma, and other lymphomas."]}]}
{"type": "biolink:Cell", "ic": "76.281523396999802", "identifiers": [{"i": "UMLS:C1513753", "l": "Multipotent Bone Marrow Stem Cell", "d": []}, {"i": "NCIT:C41058", "l": "Multipotent Bone Marrow Stem Cell", "d": ["A bone marrow myeloid stem cell that can differentiate into all the blood lineages."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:4033047", "l": "OFF midget ganglion cell", "d": ["A midget ganglion cell that depolarizes in response to decreased light intensity in the center of its receptive field. The majority of input that this cell receives comes from flat midget bipolar cells."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5216301", "l": "Nucleated cells|NCnc|Pt|Pericard fld", "d": []}]}
{"type": "biolink:Cell", "ic": "70.595126831462238", "identifiers": [{"i": "CL:0000669", "l": "pericyte", "d": ["An elongated, contractile cell found wrapped about precapillary arterioles outside the basement membrane. Pericytes are present in capillaries where proper adventitia and muscle layer are missing (thus distingushing this cell type from adventitial cells). They are relatively undifferentiated and may become fibroblasts, macrophages, or smooth muscle cells."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0682519", "l": "rodent cell line", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157614", "l": "CD55+CD59 cells | Blood | Cell markers", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5419240", "l": "Cenplacel-L", "d": []}, {"i": "NCIT:C171653", "l": "Cenplacel-L", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5707721", "l": "Anti-CEA CAR T Cells", "d": []}, {"i": "NCIT:C188356", "d": []}]}
{"type": "biolink:Cell", "ic": "31.934791552705786", "identifiers": [{"i": "CL:0000255", "l": "eukaryotic cell", "d": []}]}
{"type": "biolink:Cell", "ic": "73.357135392541679", "identifiers": [{"i": "CL:0000622", "l": "acinar cell", "d": ["A secretory cell that is grouped together with other cells of the same type to form grape shaped clusters known as acini (singular acinus)."]}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "UMLS:C0596508", "l": "Embryonic Stem Cells", "d": []}, {"i": "NCIT:C12935", "l": "Embryonic Stem Cell", "d": ["Embryonic stem (ES) cells are cells derived from the inner cell mass of the early embryo that can be propagated indefinitely in the primitive undifferentiated state while remaining pluripotent."]}, {"i": "MESH:D053595", "l": "Embryonic Stem Cells", "d": []}, {"i": "SNOMEDCT:419965008", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5216240", "l": "Leukocytes|NCnc|Pt|Stool", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5417758", "l": "Zynteglo", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0333806", "l": "Macrocytic normochromic erythrocyte", "d": []}, {"i": "SNOMEDCT:7841003", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C2830065", "l": "Romyelocel-L", "d": []}, {"i": "NCIT:C82381", "l": "Romyelocel-L", "d": ["Early-to late-stage myeloid progenitor cells derived from adult human stem cells with potential hematopoietic activity. Upon infusion, human myeloid progenitor cells CLT-008 proliferate into mature myeloid cells, including granulocytes, macrophages, platelets, and erythrocytes.  These myeloid progenitor cells die within forty-five days after a burst of hematopoiesis. This agent cannot create lymphoid cells, including T cells associated with graft-versus-host disease (GVHD)."]}]}
{"type": "biolink:Cell", "ic": "64.898660913853604", "identifiers": [{"i": "CL:0000700", "l": "dopaminergic neuron", "d": ["A neuron that releases dopamine as a neurotransmitter."]}]}
{"type": "biolink:Cell", "ic": "87.120474278337809", "identifiers": [{"i": "CL:0008025", "l": "noradrenergic neuron", "d": ["A neuron that release noradrenaline (noriphinephrine) as a neurotransmitter."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:1000420", "l": "myoepithelial cell of terminal lactiferous duct", "d": ["A myoepithelial cell that is part of the terminal lactiferous duct."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0000043", "l": "mature basophil", "d": ["A fully differentiated basophil, a granular leukocyte with an irregularly shaped, pale-staining nucleus that is partially constricted into two lobes, and with cytoplasm that contains coarse granules of variable size. Basophils contain vasoactive amines such as histamine and serotonin, which are released on appropriate stimulation."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C4726557", "l": "Autologous CISH-inactivated TILs", "d": []}, {"i": "NCIT:C151926", "l": "Autologous CISH-inactivated TILs", "d": ["A preparation of autologous tumor-infiltrating lymphocytes (TILs) where the cytokine-inducible SH2-containing protein gene (CISH) has been inactivated using the clustered regularly interspaced short palindromic repeat (CRISPR)/CRISPR associated protein 9 (Cas9) editing system, containing guide RNA (gRNA) coupled to a recombinant form of the DNA endonuclease Cas9, with potential immunomodulating and antineoplastic activities. Using the CRISPR/Cas9 system, the autologous TILs are transfected, ex vivo, with a plasmid encoding for a gRNA that site-specifically targets and binds to the human CISH gene. Cas9 cleaves these specific DNA sites, which causes double strand breaks, disrupts the gene encoding CISH and prevents transcription. Upon intravenous administration, the autologous CISH-inactivated TILs are able to induce a T-cell-mediated immune response against tumor cells. CISH, a member of the suppressor of cytokine signaling family (SOCS; cytokine-induced STAT inhibitor; STAT-induced STAT inhibitor; SSI), is induced by T-cell receptor (TCR) stimulation. CISH plays a key role in the negative regulation of both T-cell signaling and CTL-mediated tumor cell eradication. The knockout of the CISH gene enhances the expansion and anti-tumor activities of effector T-cells."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:4033001", "l": "endothelial cell of arteriole of lymph node", "d": ["A(n) endothelial cell that is part of a(n) arteriole of lymph node."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:1000341", "l": "enterocyte of epithelium proper of jejunum", "d": ["An enterocyte that is part of the epithelium proper of jejunum."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5171963", "l": "Malignant cells | Peritoneal fluid | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:1001578", "l": "vagina squamous cell", "d": ["Squamous cell of vaginal epithelium."]}]}
{"type": "biolink:Cell", "ic": "75.58416670140862", "identifiers": [{"i": "UMLS:C1709168", "l": "Neoplastic Chromaffin Cell", "d": []}, {"i": "NCIT:C48559", "l": "Neoplastic Chromaffin Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "76.659841615658792", "identifiers": [{"i": "UMLS:C0596030", "l": "Acinar Cell", "d": []}, {"i": "NCIT:C13077", "l": "Acinar Cell", "d": ["A secreting cell that lines an acinus (i.e. a small sac or sac-like structure).  A representative example is the acinar cell located in the pancreas that produces pancreatic enzymes and juices."]}, {"i": "MESH:D061354", "l": "Acinar Cells", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0000200", "l": "touch receptor cell", "d": []}]}
{"type": "biolink:Cell", "ic": "76.281523396999802", "identifiers": [{"i": "CL:0001029", "l": "common dendritic progenitor", "d": ["Common dendritic precursor is a hematopoietic progenitor cell that is CD117-low, CD135-positive, CD115-positive and lacks plasma membrane parts for hematopoietic lineage markers."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002152", "l": "columnar cell of endocervix", "d": ["A columnar cell of the cervix uteri."]}]}
{"type": "biolink:Cell", "ic": "88.140761698499901", "identifiers": [{"i": "CL:0002398", "l": "Gr1-positive, CD43-positive monocyte", "d": ["An intermediate monocyte that is Gr1-positive, CD43-positive."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157492", "l": "CD34 blasts | XXX | Cell markers", "d": []}]}
{"type": "biolink:Cell", "ic": "54.083535053380338", "identifiers": [{"i": "CL:0000037", "l": "hematopoietic stem cell", "d": ["A stem cell from which all cells of the lymphoid and myeloid lineages develop, including blood cells and cells of the immune system. Hematopoietic stem cells lack cell markers of effector cells (lin-negative). Lin-negative is defined by lacking one or more of the following cell surface markers: CD2, CD3 epsilon, CD4, CD5 ,CD8 alpha chain, CD11b, CD14, CD19, CD20, CD56, ly6G, ter119."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0883472", "l": "CD3-CD16+CD56+ cell", "d": []}, {"i": "SNOMEDCT:732281006", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2325537", "l": "Epithelial cell of lactiferous gland", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1267924", "l": "Lymphocyte positive for CD42D antigen", "d": []}, {"i": "SNOMEDCT:117368009", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4038490", "l": "Cells.diploid.S phase", "d": []}]}
{"type": "biolink:Cell", "ic": "55.536416517142456", "identifiers": [{"i": "CL:0000945", "l": "lymphocyte of B lineage", "d": ["A lymphocyte of B lineage with the commitment to express an immunoglobulin complex."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5178304", "l": "Promonocytes/100 leukocytes | Body fluid | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5670695", "l": "Anti-5T4 CAR-NK Cells", "d": []}, {"i": "NCIT:C186665", "l": "Anti-5T4 CAR-NK Cells", "d": ["A preparation of allogeneic natural killer cells (NKs) expressing a chimeric antigen receptor (CAR) specific for the tumor-associated antigen (TAA) oncofetal trophoblast glycoprotein (5T4; TPBG; Wnt-activated inhibitory factor 1 or WAIF1), with potential immunomodulating and antineoplastic activities. Upon transfusion, the anti-5T4 CAR-NK cells recognize, bind to and induce selective cytotoxicity in 5T4-expressing tumor cells. 5T4, a transmembrane glycoprotein, is overexpressed by a variety of cancer cell types; its expression is correlated with increased invasiveness."]}]}
{"type": "biolink:Cell", "ic": "86.236661114203869", "identifiers": [{"i": "CL:0000377", "l": "tracheoblast", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5216254", "l": "Lymphocytes|NCnc|Pt|Plr fld", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0000882", "l": "thymic medullary macrophage", "d": ["A thymic macrophage found in the thymic medulla."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C4682464", "l": "Autologous ACTR-CD16-CD28-expressing T-lymphocytes ACTR707", "d": []}, {"i": "NCIT:C139730", "l": "Autologous ACTR-CD16-CD28-expressing T-lymphocytes ACTR707", "d": ["A preparation of autologous T-lymphocytes that have been genetically modified, using proprietary Antibody-Coupled T-cell Receptor (ACTR) technology, to express a chimeric protein containing, at least, the extracellular Fc receptor domain of CD16, normally found on certain immune cells, such as natural killer (NK) cells, coupled to the co-stimulatory signaling domain of CD28, with potential immunostimulating and antineoplastic activities. Upon reintroduction into the patient with co-administration of a cancer-specific antibody, the co-administered antibody targets and binds to the tumor-associated antigen (TAA) expressed on the tumor cell. In turn, the autologous ACTR-CD16-CD28-expressing T-lymphocytes ACTR707 bind to the antibody, become activated and induce the destruction of the tumor cells by a) releasing cytotoxins that directly kill cancer cells; b) releasing cytokines that trigger an immune response and recruit other immune-mediated killer cells to kill the tumor cells; c) targeting and killing adjacent tumor cells that are not bound to the antibody; d) inducing T-cell proliferation and thereby further enhancing the T-cell mediated tumor cell attack. Compared to other T-cell products, ACTR-based products do not target a specific TAA and can potentially be used in a variety of tumors because targeting is based on the specificity of the co-administered antibody."]}]}
{"type": "biolink:Cell", "ic": "90.82444074280258", "identifiers": [{"i": "CL:0000703", "l": "sustentacular cell", "d": ["Cell that provides some or all mechanical, nutritional and phagocytic support to their neighbors."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1522153", "l": "Leukocyte - Monoblast (MMHCC)", "d": []}, {"i": "NCIT:C22584", "l": "Mouse Monoblast", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C4287777", "l": "PRAME-targeting T-cell Receptor/Inducible Caspase 9 BPX-701", "d": []}, {"i": "NCIT:C128029", "l": "PRAME-targeting T-cell Receptor/Inducible Caspase 9 BPX-701", "d": ["Human allogeneic T-lymphocytes transduced with a retroviral vector encoding a high-affinity T-cell receptor (TCR) specific for human leukocyte antigen (HLA)-A2-01-restricted, preferentially-expressed antigen in melanoma (PRAME) and containing the chemical induction of dimerization (CID) suicide/safety switch, composed of a drug binding domain coupled to the signaling domain of the suicide enzyme caspase-9, with potential antineoplastic activity. Peripheral blood mononuclear cells (PBMCs) are isolated from a patient, transduced with an anti-PRAME-HLA-A2 restricted TCR, expanded ex vivo, and reintroduced into the HLA-A2-positive patient. Upon reintroduction, PRAME-targeting T-cell receptor-based therapy BPX-701 binds to tumor cells expressing PRAME, which may induce cell death in and halt the growth of PRAME-expressing cancer cells. The tumor-associated antigen PRAME is overexpressed by a variety of cancer cell types. If potential T-cell toxicity due to graft-versus-host disease (GvHD) occurs, the chemical dimerizer rimiducid (AP1903) can be adminstered. Rimiducid binds to the drug binding domain expressed by the BPX-701 T-cells, and triggers activation of the caspase-9 domain, which leads to caspase 9-mediated signaling, the induction of apoptosis and to selective and complete elimination of BPX-701 cells."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002161", "l": "superficial external epithelial cell of tympanic membrane", "d": ["A cell type found on the superficial layer of the external side of the tympanic membrane. This cell-type lacks a nucleus."]}]}
{"type": "biolink:Cell", "ic": "74.804588241401973", "identifiers": [{"i": "UMLS:C1708877", "l": "Malignant Fibrohistiocytic Cell", "d": []}, {"i": "NCIT:C49062", "l": "Malignant Fibrohistiocytic Cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5177475", "l": "Plasma cells/100 leukocytes | Peritoneal fluid | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0945932", "l": "Cells.CD42", "d": []}]}
{"type": "biolink:Cell", "ic": "86.236661114203869", "identifiers": [{"i": "UMLS:C1513933", "l": "Neoplastic Myeloblast with Basophilic Cytoplasm", "d": []}, {"i": "NCIT:C37066", "l": "Neoplastic Myeloblast with Basophilic Cytoplasm", "d": []}]}
{"type": "biolink:Cell", "ic": "44.060205959844325", "identifiers": [{"i": "CL:0000133", "l": "neurectodermal cell", "d": ["Ectoderm destined to be nervous tissue."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:2000066", "l": "cardiac ventricle fibroblast", "d": ["Any fibroblast that is part of a cardiac ventricle."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5552872", "l": "Autologous NKG2D CAR T Cells KD-025", "d": []}, {"i": "NCIT:C179622", "l": "Autologous NKG2D CAR T Cells KD-025", "d": ["A preparation of autologous T-lymphocytes that have been genetically modified to express a chimeric antigen receptor (CAR) encoding human natural-killer group 2, member D receptor protein (NKG2D or KLRK1) coupled to the co-immunostimulatory signaling domain 4-1BB, normally expressed on T-cells, and linked to the intracellular CD3 zeta domain (CD3z), which is needed for TCR signaling, with potential immunostimulating and antineoplastic activities. Upon infusion back into the patient, autologous NKG2D CAR T cells KD-025 specifically recognize and bind to tumor cells expressing NKG2D ligands (NKG2DLs), resulting in cytokine secretion and lysis of NKG2D ligand-expressing tumor cells. NKG2DLs, such as MICA, MICB, and members of the UL16-binding proteins (ULBP)/retinoic acid early transcript 1 (RAET1) family, are overexpressed on a variety of cancer cell types, but are not expressed on most normal, healthy cells."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5205632", "l": "Adipose-derived Expanded Mesenchymal Stem Cells SCM-010", "d": []}, {"i": "NCIT:C160891", "l": "Adipose-derived Expanded Mesenchymal Stem Cells SCM-010", "d": ["A preparation of human adipose-derived mesenchymal stem cells (MSCs), that can potentially be used for engraftment purposes in certain autoimmune disorders. Upon intrathecal administration, adipose-derived expanded mesenchymal stem cells SCM-010 migrate to the bone marrow. These MSCs are pluripotent and capable of differentiating along specific lineages and may activate the immune system and repair damage to the nervous system."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4696696", "l": "Cells.CD19+CD27+IgD+IgM+", "d": []}]}
{"type": "biolink:Cell", "ic": "88.140761698499901", "identifiers": [{"i": "CL:0000122", "l": "stellate neuron", "d": ["A neuron that has dendritic processes radiating from the cell body forming a star-like shape."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1180243", "l": "Endothelial cell of venule", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5161703", "l": "Cytokeratin cells | Blood | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2335177", "l": "Mesothelial cell of visceral pleura", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C4724730", "l": "Autologous Mesothelin-specific CAR-T-Cells Expressing Anti-PD-1/CTLA-4 Antibodies", "d": []}, {"i": "NCIT:C150682", "l": "Autologous Mesothelin-specific CAR-T-Cells Expressing Anti-PD-1/CTLA-4 Antibodies", "d": ["A preparation of autologous, engineered T-lymphocytes that express both a second-generation chimeric antigen receptor (CAR) specific for the human gastric carcinoma-associated antigen MG7, and the co-stimulatory molecule 4-1BB (CD137), with potential antineoplastic activity. Upon intratumoral injection, the autologous anti-MG7-CAR T-lymphocytes target and attach to cancer cells expressing MG7. This induces selective toxicity in and causes lysis of MG7-expressing tumor cells. MG7, a glycosylated protein sequence from the tumor-associated antigen (TAA) carcinoembryonic antigen (CEA), plays a key role in the development of certain tumor cell types. 4-1BB enhances T-cell activation and signaling after recognition of MG7."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1257741", "l": "BALB 3T3 Cells", "d": []}, {"i": "MESH:D041702", "l": "BALB 3T3 Cells", "d": []}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "UMLS:C2936411", "l": "Th17 Cells", "d": []}, {"i": "NCIT:C113815", "l": "T Helper 17 Cell", "d": ["A subset of helper T-lymphocytes which synthesize and secrete the interleukins (IL), IL-17A, -21 and -22. These cytokines mediate inflammation by increasing chemokine production, which leads to the recruitment of both monocytes and neutrophils to sites of infection or inflammation. Th17 cells modulate both host immunity against extracellular bacteria and fungi and inflammation. Overexpression of these cells is associated with tissue injury caused by autoimmune diseases."]}, {"i": "MESH:D058504", "l": "Th17 Cells", "d": []}]}
{"type": "biolink:Cell", "ic": "87.120474278337809", "identifiers": [{"i": "UMLS:C4745256", "l": "Adenocarcinoma Cell with Abundant Pale Cytoplasm", "d": []}, {"i": "NCIT:C54724", "l": "Adenocarcinoma Cell with Abundant Pale Cytoplasm", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002538", "l": "intrahepatic cholangiocyte", "d": ["An epithelial cell of the intrahepatic portion of the bile duct. These cells are flattened or cuboidal in shape, and have a small nuclear-to-cytoplasmic ratio relative to large/extrahepatic cholangiocytes."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157660", "l": "CD79a cells | Blood | Cell markers", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1267798", "l": "CV+ lymphocyte", "d": []}, {"i": "SNOMEDCT:117502008", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:1000340", "l": "enterocyte of epithelium proper of duodenum", "d": ["An enterocyte that is part of the epithelium proper of duodenum."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:4030038", "l": "CD24-positive, CD-133-positive, vimentin-positive proximal tubular cell", "d": ["A CD24-positive, CD-133-positive, vimentin-positive cell found scattered throughout a renal proximal tubule and that may participate in tubular regeneration. Compared to other proximal tubular cell types, this cell contains less cytoplasm, fewer mitochondria and no brush border."]}]}
{"type": "biolink:Cell", "ic": "92.728541327098611", "identifiers": [{"i": "UMLS:C1514105", "l": "Neoplastic Subependymal Glial Cell", "d": []}, {"i": "NCIT:C41451", "l": "Neoplastic Subependymal Glial Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "78.185623981295834", "identifiers": [{"i": "UMLS:C1518994", "l": "Peripheral B-Lymphocyte", "d": []}, {"i": "NCIT:C38330", "l": "Peripheral B-Lymphocyte", "d": ["A mature B-lymphocyte outside the bone marrow. It may be in the general circulation or in lymphatic tissue."]}]}
{"type": "biolink:Cell", "ic": "89.347505587204751", "identifiers": [{"i": "UMLS:C0027884", "l": "Neurons, Efferent", "d": []}, {"i": "NCIT:C12643", "l": "Efferent Neuron", "d": ["A neuron that sends impulses from the central nervous system to skeletal muscles, glands, and visceral organs."]}, {"i": "MESH:D009476", "l": "Neurons, Efferent", "d": []}]}
{"type": "biolink:Cell", "ic": "83.552982069901191", "identifiers": [{"i": "UMLS:C0014793", "l": "Abnormal Red Blood Cell", "d": []}, {"i": "NCIT:C12522", "l": "Abnormal Red Blood Cell", "d": []}, {"i": "MESH:D004913", "l": "Erythrocytes, Abnormal", "d": []}, {"i": "SNOMEDCT:397019006", "d": []}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "CL:0009028", "l": "intestinal crypt stem cell of appendix", "d": ["An intestinal crypt stem cell that is located in the vermiform appendix. These stem cells reside at the bottom of crypts in the appendix and are highly proliferative. They either differentiate into transit amplifying cells or self-renew to form new stem cells."]}]}
{"type": "biolink:Cell", "ic": "69.78964318410506", "identifiers": [{"i": "UMLS:C1708909", "l": "Malignant Smooth Muscle Cell", "d": []}, {"i": "NCIT:C49124", "l": "Malignant Smooth Muscle Cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0205869", "l": "Perivascular Oligodendroglia", "d": []}]}
{"type": "biolink:Cell", "ic": "83.023198044254755", "identifiers": [{"i": "CL:0002001", "l": "CD34-positive, CD38-positive granulocyte monocyte progenitor", "d": ["A granulocyte monocyte progenitor is CD34-positive, CD38-positive, IL-3receptor-alpha-positive and is CD45RA-negative."]}]}
{"type": "biolink:Cell", "ic": "90.82444074280258", "identifiers": [{"i": "CL:0002292", "l": "type I cell of carotid body", "d": ["A round or oval neuroepithelial cell that contacts other type I cells or capillaries. They occur in clusters that are surrounded by sheath cells (type-II cells) in the carotid body. This cell type is capable of secreting a number of neurotransmitters."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0000939", "l": "CD16-positive, CD56-dim natural killer cell, human", "d": ["A mature natural killer cell that has the phenotype CD56-low, CD16-positive and which is capable of cytotoxicity and cytokine production."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4533461", "l": "Cells.CD4-CD8-CD45R+TCR alpha beta+", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C0229628", "l": "Basophilic normoblast", "d": []}, {"i": "NCIT:C13130", "l": "Basophilic Erythroblast", "d": ["A nucleated red blood cell that stains readily with basic dye."]}, {"i": "SNOMEDCT:464005", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002511", "l": "CD11b-low, CD103-negative, langerin-negative lymph node dendritic cell", "d": ["A langerin-negative lymph node dendritic cell that is CD103-negative and CD11b-low."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5220574", "l": "Epithelial cells.non-squamous|Urine/Urine sed", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5206711", "l": "Chimeric Costimulatory Converting Receptor-modified NK-92 Cells", "d": []}, {"i": "NCIT:C162637", "l": "Chimeric Costimulatory Converting Receptor-modified NK-92 Cells", "d": ["A preparation of genetically-modified natural killer (NK) cells derived from the allogeneic NK-92 cell line that are transduced with an as of yet unspecified chimeric costimulatory converting receptor (CCCR) for cancer retargeting purposes, with potential cytolytic, immunomodulating and antineoplastic activities. Upon infusion of the CCCR-modified NK-92 cells, the redirected NK cells recognize and bind to tumor cells. This leads to the secretion and release of perforins, granzymes, cytokines and chemokines, which results in selective tumor cell lysis. The NK-92 cells are derived from a human cytotoxic cell line composed of allogeneic, activated, interleukin-2-(IL-2) dependent-NK cells from a 50-year old male patient with rapidly progressive non-Hodgkin's lymphoma. As NK-92 cells are devoid of killer inhibitory receptors (KIRs; also called killer cell immunoglobulin-like receptors), which are negative regulators of NK cell activity, cancer cells are unable to suppress the cancer cell killing ability of the NK-92 cells."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5177477", "l": "Plasma cells/100 leukocytes | Synovial fluid | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C3871181", "l": "Erythrocytes.hyperchromic", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C4289953", "l": "Autologous CD34-positive Hematopoietic Progenitor Cells", "d": []}, {"i": "NCIT:C128249", "l": "Autologous CD34-positive Hematopoietic Progenitor Cells", "d": ["A population of autologous CD34-positive hematopoietic progenitor cells (HPCs) that can be used for autotransplantation. CD34+ HPCs are isolated from human blood stem cells upon apheresis. Upon transplantation with the CD34+ HPCs, these cells can differentiate into a variety of cell types including fibroblasts, osteoblasts, chondrocytes, myocytes, adipocytes, and endothelial cells."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002416", "l": "mature Vgamma1.1-positive, Vdelta6.3-positive thymocyte", "d": ["A Vgamma1.1-positive, Vdelta6.3-positive thymocyte that is CD24-negative."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157350", "l": "CD19+CD103+ cells | Blood | Cell markers", "d": []}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "CL:0002020", "l": "GlyA-positive reticulocytes", "d": ["A reticulocyte that is GlyA-positive."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0022539", "l": "KB Cells", "d": []}, {"i": "MESH:D007624", "l": "KB Cells", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0004224", "l": "AB diffuse-2 amacrine cell", "d": ["A broadly stratifying amacrine cell that has a small dendritic field and post-synaptic terminals in S2 and S3. This cell type releases the neurotransmitter glycine."]}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "UMLS:C1516671", "l": "Clonal Hematopoietic Stem Cell", "d": []}, {"i": "NCIT:C37061", "l": "Clonal Hematopoietic Stem Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "63.323668158560849", "identifiers": [{"i": "CL:0000233", "l": "platelet", "d": ["A non-nucleated disk-shaped cell formed by extrusion from megakaryocytes, found in the blood of all mammals, and mainly involved in blood coagulation."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0483182", "l": "CD16+CD56+CD3-", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002291", "l": "X chromosome-bearing sperm cell", "d": ["A sperm bearing an X chromosome. Chromosomal and genetic sex is established at fertilization in mammals and depends upon whether an X-bearing sperm or a Y-bearing sperm fertilizes the X-bearing ovum."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C4086501", "l": "Human Umbilical Cord Perivascular Cell", "d": []}, {"i": "NCIT:C124146", "l": "Human Umbilical Cord Perivascular Cell", "d": ["Mesenchymal stem cells isolated from umbilical cord blood capable of high proliferation potential and colony formation capacity in vitro and the ability to proliferate and differentiate to an osteogenic phenotype in culture."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2328697", "l": "Hemal cell", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1706985", "l": "Bone Marrow Stem Cell with Potential for Megakaryocytic and Erythroid Differentiation", "d": []}, {"i": "NCIT:C43225", "l": "Bone Marrow Stem Cell with Potential for Megakaryocytic and Erythroid Differentiation", "d": ["An undifferentiated cell which can undergo division and can give rise to either a megakaryocyte or a cell in the erythrocytic series."]}]}
{"type": "biolink:Cell", "ic": "88.140761698499901", "identifiers": [{"i": "UMLS:C1707939", "l": "Neoplastic Epithelioid Smooth Muscle Cell", "d": []}, {"i": "NCIT:C49117", "l": "Neoplastic Epithelioid Smooth Muscle Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "71.51239634443381", "identifiers": [{"i": "CL:0000492", "l": "CD4-positive helper T cell", "d": ["A CD4-positive, alpha-beta T cell that cooperates with other lymphocytes via direct contact or cytokine release to initiate a variety of immune functions."]}]}
{"type": "biolink:Cell", "ic": "92.728541327098611", "identifiers": [{"i": "CL:0008049", "l": "Betz cell", "d": ["A giant pyramidal neuron with a soma in layer Vb of the primary motor cortex that sends its axons down the spinal cord via the corticospinal tract, either synapsing directly with alpha motor neurons, or targeting interneurons in the spinal cord. In humans, Betz cells are the largest known in the central nervous system."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002574", "l": "stromal cell of pancreas", "d": ["A stromal cell of the pancreas."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2717940", "l": "Hep G2 Cells", "d": []}, {"i": "MESH:D056945", "l": "Hep G2 Cells", "d": []}]}
{"type": "biolink:Cell", "ic": "84.75972595860604", "identifiers": [{"i": "CL:0002357", "l": "fetal derived definitive erythrocyte", "d": ["A fetal liver derived enucleated erythrocyte. This erythrocyte resembles adult erythrocytes in that they are small (3- to 6- times smaller than primitive erythrocytes) and produce adult hemaglobins."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C3896582", "l": "Ex Vivo-activated Autologous Lymph Node Lymphocytes", "d": []}, {"i": "NCIT:C114985", "l": "Ex Vivo-activated Autologous Lymph Node Lymphocytes", "d": ["Autologous human lymph node T-lymphocytes, with potential immunostimulatory and antineoplastic activity. Upon collection of immune cells from the tumor-draining lymph node, the human lymph node lymphocytes are activated with anti-CD3/anti-CD28 microbeads, cultured with recombinant, human interleukin-2 (IL-2), expanded and isolated ex vivo. Upon reintroduction into the patient, the ex vivo-activated autologous lymph node lymphocytes recognize and lyse the tumor cells."]}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "CL:0000747", "l": "cyanophore", "d": ["A pigment cell derived from the neural crest. Contains blue pigment of unknown chemical composition in fibrous organelles termed cyanosomes. This gives a blue appearance."]}]}
{"type": "biolink:Cell", "ic": "55.496520272662487", "identifiers": [{"i": "CL:0000188", "l": "cell of skeletal muscle", "d": ["A somatic cell located in skeletal muscle."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5177799", "l": "Polymorphonuclear cells/leukocytes | Pleural fluid | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C4527256", "l": "Allogeneic CD3- CD19- CD57+ NKG2C+ NK Cells FATE-NK100", "d": []}, {"i": "NCIT:C137863", "l": "Allogeneic CD3- CD19- CD57+ NKG2C+ NK Cells FATE-NK100", "d": ["A preparation of pharmacologically-enriched, allogeneic natural killer (NK) cells derived from a related but not completely matched human leukocyte antigen (HLA)-haploidentical donor that is seropositive for cytomegalovirus (CMV+), with potential cytolytic and antineoplastic activities. Upon leukapheresis, the donor peripheral blood mononuclear cells (PBMCs) are treated to remove T-lymphocytes (CD3+) and B-lymphocytes (CD19+). The remaining leukocytes are cultured for 7 days with the cytokine interleukin-15 (IL-15) and a small molecule inhibitor of glycogen synthase kinase 3-beta (GSK3beta) to generate the adaptive, CD3- CD19- CD57+ NKG2C+ NK cells FATE-NK100 ex vivo. Upon infusion of the allogeneic CD3- CD19- CD57+ NKG2C+ NK cells FATE-NK100, these cells selectively recognize and bind to tumor cells, and secrete perforins, granzymes, and cytokines, which results in cancer cell lysis. Exposure to CMV induces the expression of the memory-like activating receptor NKG2C and the maturation marker CD57 in the isolated NK cells, making them more potent than those not pre-exposed to CMV. CD57 both enhances the effector function of NK cells and stimulates CD16-dependent signaling. Treatment with IL-15 enhances NK cell proliferation and survival. The GSK3beta inhibitor induces preferential expansion of CD57+ NK cells that exhibit enhanced interferon (IFN)-gamma production."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C4733647", "l": "Autologous Anti-CD19CAR-HER2t/CD22CAR-EGFRt-expressing T-cells", "d": []}, {"i": "NCIT:C155897", "l": "Autologous Anti-CD19CAR-HER2t/CD22CAR-EGFRt-expressing T-cells", "d": ["A preparation of autologous human T-lymphocytes engineered to express dual chimeric antigen receptors (CARs) consisting of both anti-CD19 and anti-CD22 binding domains, fused to an as of yet undisclosed co-stimulatory domain, and linked to truncated forms of the human epidermal growth factor receptor 2 (HER2t) and the human epidermal growth factor receptor (EGFRt), respectively with potential immunostimulating and antineoplastic activities. Upon administration, the autologous anti-CD19CAR-HER2t/CD22CAR-EGFRt-expressing T-cells bind to CD19 and CD22 on the surface of, and induce selective toxicity against tumor cells expressing CD19 and CD22. Devoid of both ligand binding domains and tyrosine kinase activity, the expressed EGFRt and HER2t facilitate both in vivo detection of the administered, transduced T-cells and can promote elimination of those cells through an antibody-dependent cellular cytotoxicity (ADCC) response. CD19 and CD22, both transmembrane phosphoglycoproteins expressed on the surface of cells in the B lineage, are often overexpressed on malignant B-cells."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0229537", "l": "Pituitary beta cell", "d": []}, {"i": "SNOMEDCT:37514005", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157269", "l": "CD11b cells | Blood | Cell markers", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002565", "l": "iris pigment epithelial cell", "d": ["A pigment cell located in the epithelium of the iris."]}]}
{"type": "biolink:Cell", "ic": "58.607364745663354", "identifiers": [{"i": "UMLS:C1513971", "l": "Neoplastic Germ Cell", "d": []}, {"i": "NCIT:C36903", "l": "Neoplastic Germ Cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0933803", "l": "Type A synoviocyte", "d": []}]}
{"type": "biolink:Cell", "ic": "92.728541327098611", "identifiers": [{"i": "CL:0011025", "l": "exhausted T cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157923", "l": "Cells | Peritoneal fluid | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C3827871", "l": "T1E28z CAR-expressing Autologous CD4-positive T Lymphocytes", "d": []}, {"i": "NCIT:C106117", "l": "T1E28z CAR-expressing Autologous CD4-positive T Lymphocytes", "d": ["Autologous CD4 positive T-lymphocytes engineered to express the chimeric antigen receptor (CAR) T1E28z containing the ErbB ligand, T1E, fused to the hinge region, transmembrane domain and endodomain of CD28 and the CD3zeta endodomain, with potential immunomodulating and antineoplastic activities. T1E, a chimeric polypeptide containing the N-terminus of human transforming growth factor (TGF)-alpha fused to the C-terminus of epidermal growth factor (EGF), binds to ErbB1 homodimers and heterodimers as well as ErbB2/3 heterodimers, but not to ErbB2 or erbB3 alone. Upon intratumoral administration, the promiscuous ErbB ligand T1E of the T1E28z CAR-expressing autologous CD4-positive T lymphocytes binds to the specific ErbB homo- and heterodimers on tumor cells. This induces selective toxicity in ErbB-expressing tumor cells resulting in tumor cell lysis. ErbB1, ErbB2 and ErbB3, members of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases, are frequently overexpressed in solid tumors and play key roles in tumor cell proliferation and tumor angiogenesis."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157627", "l": "CD59 Monocytes | Blood | Cell markers", "d": []}]}
{"type": "biolink:Cell", "ic": "92.728541327098611", "identifiers": [{"i": "UMLS:C1514733", "l": "Rat Cell Line", "d": []}, {"i": "NCIT:C20222", "l": "Rat Cell Line", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4322819", "l": "CD198+ T lymphocyte", "d": []}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "UMLS:C0027625", "l": "Circulating Neoplastic Cells", "d": []}, {"i": "NCIT:C63797", "l": "Circulating Tumor Cell", "d": ["A metastatic cancer cell found in the peripheral blood."]}, {"i": "MESH:D009360", "l": "Neoplastic Cells, Circulating", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5154487", "l": "Basophils.immature/100 leukocytes | Blood | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5426635", "l": "Cells.CD3-CD14-CD45+CD56+DOCK8+", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:1000493", "l": "mesothelial cell of visceral pleura", "d": ["A mesothelial cell that is part of the visceral pleura."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C4764237", "l": "EDTA Blood Cell Fraction", "d": []}, {"i": "NCIT:C158462", "l": "EDTA Blood Cell Fraction", "d": ["The blood cells that are harvested from a cell collection tube containing EDTA."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0229616", "l": "Small lymphocyte", "d": []}, {"i": "SNOMEDCT:91233007", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5557362", "l": "Autologous Anti-KK-LC-1 TCR-expressing T-cells", "d": []}, {"i": "NCIT:C181918", "l": "Autologous Anti-KK-LC-1 TCR-expressing T-cells", "d": ["A preparation of autologous T-lymphocytes that have been genetically engineered to express a T-cell receptor (TCR) specific for the tumor-associated antigen (TAA) Kita-Kyushu lung cancer antigen-1 (KK-LC-1), with potential immunomodulating and antineoplastic activities. Upon administration, the autologous anti-KK-LC-1 TCR-expressing T-cells specifically target and bind to KK-LC-1-expressing tumor cells. This leads to T-cell activation and T-cell mediated lysis of KK-LC-1-expressing tumor cells. KK-LC-1, a cancer germline (CG) antigen, is expressed in a variety of epithelial cancers and has restricted expression in normal tissues."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4518175", "l": "Population of all immature granulocytes in portion of fluid", "d": []}, {"i": "SNOMEDCT:726595000", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1440233", "l": "Cell positive for CD100 antigen", "d": []}, {"i": "SNOMEDCT:725325003", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1267953", "l": "Lymphocyte positive for CD62E antigen", "d": []}, {"i": "SNOMEDCT:117394000", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C4085999", "l": "Autologous Anti-CD123 CAR TCR/4-1BB-expressing T-lymphocytes", "d": []}, {"i": "NCIT:C125101", "l": "Autologous Anti-CD123 CAR TCR/4-1BB-expressing T-lymphocytes", "d": ["Autologous, genetically engineered T-lymphocytes that have been electroporated with a messenger RNA (mRNA) encoding a chimeric antigen receptor (CAR) consisting of an anti-human interleukin-3 receptor alpha chain (IL3RA; CD123) single chain variable fragment (scFv) coupled to the co-stimulatory signaling domains of 4-1BB (CD137) and the zeta chain of the T-cell receptor (TCR) CD3 complex (CD3-zeta), with potential immunomodulating and antineoplastic activities.  Upon transfusion, the mRNA-electroporated autologous anti-CD123 CAR TCR/4-1BB expressing T-lymphocytes attach to cancer cells expressing CD123. This induces selective toxicity in and causes lysis of CD123-expressing tumor cells. The 4-1BB co-stimulatory molecule signaling domain enhances T-cell activation and signaling after recognition of CD123. CD123 is normally expressed on committed blood progenitor cells in the bone marrow; its overexpression is associated with both increased leukemic cell proliferation and aggressiveness."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5171724", "l": "Lymphocytes/100 cells | Lymph node | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "ic": "90.82444074280258", "identifiers": [{"i": "CL:0002228", "l": "primary lens fiber", "d": ["An elongating cell that rapidly obliterates the lumen of the lens vesicle. Subsequently, differentiation of this cell type at the lens equator leads to the formation of secondary fiber cells that come to overlie the primary fibers."]}]}
{"type": "biolink:Cell", "ic": "85.457082654197222", "identifiers": [{"i": "CL:0002250", "l": "intestinal crypt stem cell", "d": ["A cell that is found in a zone occupying the bottom region of the crypt; provide the source of most of the cell types of the intestinal epithelium; proliferate by mitotic division; differentiates into columnar or goblet cells."]}]}
{"type": "biolink:Cell", "ic": "88.140761698499901", "identifiers": [{"i": "CL:0002377", "l": "immature Schwann cell", "d": ["A glial cell that develops from a Schwann cell precursor. The immature Schwann cell is embedded among neurons (axons) with minimal extracellular spaces separating them from nerve cell membranes and has a basal lamina. Cells can survive without an axon present. Immature Schwann cell can be found communally ensheathing large groups of axons."]}]}
{"type": "biolink:Cell", "ic": "90.82444074280258", "identifiers": [{"i": "CL:0002341", "l": "basal cell of prostate epithelium", "d": ["An undifferentiated cell of the prostate epithelium that lacks secretory activity."]}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "UMLS:C0229473", "l": "Cell of Claudius", "d": []}, {"i": "NCIT:C12478", "l": "Clear Cell", "d": ["A cell with empty-appearing cytoplasm when viewed with a light microscope."]}, {"i": "SNOMEDCT:40489007", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2951025", "l": "Endothelial cell of endocardium for right atrium", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:1000372", "l": "transitional myocyte of atrial part of atrioventricular bundle", "d": ["A transitional myocyte that is part of the atrial part of atrioventricular bundle."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002358", "l": "pyrenocyte", "d": ["Derived from the Greek word pyren (the pit of a stone fruit), this is a transient nucleated cell type that results from exclusion of the nucleus from the primitive erythrocyte."]}]}
{"type": "biolink:Cell", "ic": "70.441195081532641", "identifiers": [{"i": "CL:0000068", "l": "duct epithelial cell", "d": ["An epithelial cell that is part of a duct."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C4289951", "l": "Autologous HBV-specific TCR-redirected T-Lymphocytes", "d": []}, {"i": "NCIT:C126270", "l": "Autologous HBV-specific TCR-redirected T-Lymphocytes", "d": ["A preparation of human autologous T-lymphocytes transduced with a viral vector encoding for a T-cell receptor (TCR) specific for a human hepatitis B virus (HBV) surface antigen (HBsAg), with potential antineoplastic activity. Following administration, the autologous HBV antigen specific TCR-redirected autologous T-lymphocytes recognize and bind to the HBV antigen-positive cells, which induces cytotoxic T-lymphocyte (CTL)-mediated elimination of HBV antigen-positive cancer cells. HBV antigens are found on HBV-positive cells and HPV-induced hepatocellular carcinoma (HCC)."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5216303", "l": "Nucleated cells|NCnc|Pt|Plr fld", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4072766", "l": "Cells.9q34 chromosome region", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C4086002", "l": "Autologous CD19CAR-CD28-CD3zeta-EGFRt-expressing Tn/mem-enriched T-lymphocytes", "d": []}, {"i": "NCIT:C124795", "l": "Autologous CD19CAR-CD28-CD3zeta-EGFRt-expressing Tn/mem-enriched T-lymphocytes", "d": ["A preparation of genetically modified autologous lymphocytes comprised of CD62L-positive naïve and memory T-cells (Tn/mem), that are transduced ex vivo with a self-inactivating (SIN) lentiviral vector expressing a hinge-optimized chimeric antigen receptor (CAR) specific for the CD19 antigen and containing CD28 and CD3 zeta signaling domains, and a truncated form of the human epidermal growth factor receptor (EGFRt), with potential immunostimulating and antineoplastic activities. Upon isolation of peripheral blood lymphocytes (PBLs), transduction of the CD62L-positive T-lymphocytes, expansion ex vivo and reintroduction of the cells into the patient, the autologous CD19R(EQ)-CD28-CD3zeta-EGFRt-expressing Tn/mem-enriched T-cells target CD19-expressing tumor cells, thereby inducing selective toxicity in CD19-expressing tumor cells. CD19 antigen is a B-cell specific cell surface antigen expressed in all B-cell lineage malignancies.  Devoid of both ligand binding domains and tyrosine kinase activity, EGFRt both facilitates in vivo detection of the administered T-cells and can promote elimination of those cells upon a cetuximab-induced antibody dependent cellular cytotoxicity response. Tn/mem T-cells include naïve T-cells, central memory T-cells (Tcm) and stem cell memory T-cells (Tscm). CD19R(EQ) contains two point mutations in the immunoglobulin (Ig) G4 spacer region, thereby preventing recognition of the CAR by Fc receptors (FcRs)."]}]}
{"type": "biolink:Cell", "ic": "89.347505587204751", "identifiers": [{"i": "CL:0002486", "l": "strial intermediate cell", "d": ["A melanocyte located between the epithelial marginal cell layer and the mesodermal basal cell layer within the intrastrial space; the predominant cellular component of the electrogenic machinery that generates an endocochlear potential (80-100 mV) ."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1183712", "l": "Luminal cell of lactiferous gland", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1440354", "l": "Cells.CD77", "d": []}]}
{"type": "biolink:Cell", "ic": "61.171215294157818", "identifiers": [{"i": "UMLS:C1513095", "l": "Melanoma Cell", "d": []}, {"i": "NCIT:C36873", "l": "Melanoma Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "CL:0002421", "l": "nucleated reticulocyte", "d": ["A reticulocyte that retains the nucleus and other organelles. Found in birds, fish, amphibians and reptiles."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C3166352", "l": "Spermatozoa.abnormal head shape", "d": []}]}
{"type": "biolink:Cell", "ic": "89.347505587204751", "identifiers": [{"i": "UMLS:C0018496", "l": "Auditory Hair Cell", "d": []}, {"i": "NCIT:C12629", "l": "Cochlear Hair Cell", "d": ["A type of sensory epithelial cell, located in the inner ear, that use hair-like projections called stereocilia to detect sound waves and transform them into neural signals that can be interpreted by the brain."]}, {"i": "MESH:D006198", "l": "Hair Cells, Auditory", "d": []}, {"i": "SNOMEDCT:52148002", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5666883", "l": "Autologous Tumor Infiltrating Lymphocytes ITIL-168", "d": []}, {"i": "NCIT:C182132", "l": "Autologous Tumor Infiltrating Lymphocytes ITIL-168", "d": ["A preparation of autologous tumor infiltrating lymphocytes (TILs) derived from each patient's digested and cryopreserved tumor, with potential immunomodulating and antineoplastic activities. Upon administration back into the patient, the autologous TILs ITIL-168 specifically recognize and kill the patient's tumor cells."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1979510", "l": "Cells.CD11c+20c+", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1267800", "l": "CYCD79+ lymphocyte", "d": []}, {"i": "SNOMEDCT:117504009", "d": []}]}
{"type": "biolink:Cell", "ic": "78.185623981295834", "identifiers": [{"i": "UMLS:C1708861", "l": "Malignant Adrenal Cortical Cell", "d": []}, {"i": "NCIT:C48363", "l": "Malignant Adrenal Cortical Cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1267934", "l": "Lymphocyte positive for CD47 antigen", "d": []}, {"i": "SNOMEDCT:117377002", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0546492", "l": "P.B. neutrophilic myelocyte", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1519220", "l": "Secretory-Stage Ameloblast", "d": []}, {"i": "NCIT:C33524", "l": "Secretory-Stage Ameloblast", "d": ["A cylindrical cell in the innermost layer of the enamel organ which deposits the organic matrix of enamel to create tooth enamel on the surface of the developing tooth."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002247", "l": "pleural macrophage", "d": ["A tissue macrophage that is in the pleural space."]}]}
{"type": "biolink:Cell", "ic": "77.271239091128209", "identifiers": [{"i": "UMLS:C1709675", "l": "Primitive Skeletal Muscle Cell", "d": []}, {"i": "NCIT:C49200", "l": "Primitive Skeletal Muscle Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C4761464", "l": "Autologous CD4+/CD8+ 4-1BB-CD3zeta-EGFR806-CAR-EGFRt/4-1BB-CD3zeta-CD19-CAR-HER2tG-expressing CARs T Cells", "d": []}, {"i": "NCIT:C157090", "l": "Autologous CD4+/CD8+ 4-1BB-CD3zeta-EGFR806-CAR-EGFRt/4-1BB-CD3zeta-CD19-CAR-HER2tG-expressing CARs T Cells", "d": ["A preparation of CD4+ and CD8+ autologous T-lymphocytes transduced with a lentiviral vector that co-expresses two different second generation chimeric antigen receptors (CARs), one composed of a short chain variable fragment (scFv) binding domain derived from depatuxizumab, a human anti-epidermal growth factor receptor (EGFR) monoclonal antibody (MAb806; ABT-806), coupled to the zeta chain of the TCR/CD3 complex (CD3-zeta) and the signaling domain of 4-1BB (CD137), and linked to a truncated form of the human epidermal growth factor receptor (EGFRt), and one composed of a short chain variable fragment (scFv) binding domain derived from an anti-CD19 monoclonal antibody, coupled to CD3-zeta) and 4-1BB,  and linked to a truncated form of the human epidermal growth factor receptor 2 (HER2tG), with potential immunostimulating and antineoplastic activities. Upon intravenous administration, the autologous CD4+/CD8+ 4-1BB-CD3zeta-EGFR806-CAR-EGFRt/4-1BB-CD3zeta- CD19-CAR-HER2tG-expressing CARs T-cells are directed to, bind to, and induce selective toxicity in EGFR deletion mutation variant III (EGFRvIII)-expressing tumor cells. The binding of these T-cells to CD19 expressed on B-cells enhances their expansion and prolongs their persistence in vivo, thereby increasing the efficacy of these CAR T-cells. Devoid of both ligand binding domains and tyrosine kinase activity, the expressed EGFRt and HER2tG facilitate in vivo detection of the administered, transduced T-cells and can promote elimination of these cells through an antibody-dependent cellular cytotoxicity (ADCC) response. HER2tG allows for enhanced binding by trastuzumab. EGFRvIII, an in-frame deletion of exons 2-7 in the EGFR gene, is overexpressed by a variety of cancer cell types but absent in normal, healthy cells. It plays a key role in tumor cell proliferation, tumor angiogenesis and resistance to both radio- and chemotherapy. Depatuxizumab specifically targets abnormal conformational states of EGFR, including EGFRvIII, and activating mutations, with lower affinity for wild-type EGFR. CD19, a transmembrane phosphoglycoprotein is expressed on the surface of cells in the B-lineage."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5575850", "l": "Autologous CD19/CD22 Chimeric Antigen Receptor T-cells CT120", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002141", "l": "active chief cell of parathyroid gland", "d": ["A parathyroid chief cell that is actively secreting hormone. Have large Golgi complexes with numerous vesicles and small membrane-bound granules; secretory granules are rare, cytoplasmic glycogen sparse, much of the cytoplasm being occupied by flat sacs of granular endoplasmic reticulum in parallel arrays; in normal humans, inactive chief cells outnumber active chief cells in a ratio of 3-5:1"]}]}
{"type": "biolink:Cell", "ic": "92.728541327098611", "identifiers": [{"i": "CL:4033017", "l": "bronchiolar smooth muscle cell", "d": ["A smooth muscle cell that is part of a bronchiole."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1267895", "l": "Lymphocyte positive for CD23 antigen", "d": []}, {"i": "SNOMEDCT:117568005", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5181218", "l": "Somatic cells | Milk | Microbiology", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C4725789", "l": "Autologous BCMA/TACI-targeted CAR T Cells AUTO2", "d": []}, {"i": "NCIT:C150509", "l": "Autologous BCMA/TACI-targeted CAR T Cells AUTO2", "d": ["A preparation of autologous T-lymphocytes that are genetically engineered to contain a dual-targeted chimeric antigen receptor (CAR), which includes the natural protein a proliferation-inducing ligand (APRIL; TNFSF13), that targets the tumor-associated antigens (TAAs) B-cell maturation antigen (BCMA; TNFRSF17) and transmembrane activator and calcium modulator and cyclophilin ligand interactor (TACI; TNFRSF13B), with potential immunomodulating and antineoplastic activities. Upon administration, the autologous BCMA/TACI-targeted CAR T-cells AUTO2 bind to BCMA and TACI expressed on tumor cells and induce selective cytotoxicity in those cells. In addition, AUTO2 carries the universal RQR8 safety \"off\" switch, which allows selective removal of the T-cells through both complement-dependent cytotoxicity (CDC) and antibody-dependent cellular cytotoxicity (ADCC) following administration of rituximab if unacceptable side-effects occur."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0333718", "l": "Anuclear cell", "d": []}, {"i": "SNOMEDCT:54656004", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2324226", "l": "Nonkeratinized cell of epithelium of inferior part of anal canal", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0000544", "l": "slowly adapting mechanoreceptor cell", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C4727554", "l": "Autologous Anti-HER2-CAR-4-1BB-CD3zeta-CD19t+-expressing Tcm-enriched T-lymphocytes", "d": []}, {"i": "NCIT:C154281", "l": "Autologous Anti-HER2-CAR-4-1BB-CD3zeta-CD19t+-expressing Tcm-enriched T-lymphocytes", "d": ["A preparation of genetically modified autologous central memory (Tcm) enriched T-cells transduced with a lentiviral vector expressing a chimeric antigen receptor (CAR) consisting of an anti-human epidermal growth factor 2 (HER2) single chain variable fragment (scFv) derived from trastuzumab, with a 4-1BB (CD137) costimulatory domain that is linked to the signaling domain of the T-cell antigen receptor complex zeta chain (CD3-zeta) (BBz), and truncated CD19 (CD19t), with potential immunostimulatory and antineoplastic activities. Upon intravenous infusion, Anti-HER2-CAR-4-1BB-CD19t+-expressing Tcm-enriched T-lymphocytes are directed against HER2-expressing cells, thereby inducing selective toxicity in HER2-expressing tumor cells. HER2, a receptor tyrosine kinase, is mutated or overexpressed in many tumor cell types, plays a significant role in tumor cell proliferation and tumor vascularization. The BBz costimulatory signaling domain enhances proliferation of T-cells and antitumor activity, while CD19t, a marker for transduction, is utilized to calculate CAR T-cell dosing and for CAR-expressing cell tracking. Tcm cells have the capacity for long-lived persistence and retain their ability to proliferate upon antigen re-encounter. The immunoglobulin G4 (IgG4) extracellular spacer contains a double mutation, (L235E;N297Q) (EQ) within the CH2 region to reduce Fc receptor recognition."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1267975", "l": "Lymphocyte positive for CD85 antigen", "d": []}, {"i": "SNOMEDCT:117415002", "d": []}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "CL:2000035", "l": "anterior lateral line neuromast mantle cell", "d": ["Any neuromast mantle cell that is part of an anterior lateral line."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2335679", "l": "Diploid germ cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5182725", "l": "Target cells | Blood | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C4053532", "l": "Circulating Epithelial Cell", "d": []}, {"i": "NCIT:C122733", "l": "Circulating Epithelial Cell", "d": ["A cell derived from an epithelial membrane that is found in the blood. These cells are associated with epithelial-mesenchymal transition and may be markers for neoplastic diseases."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1524102", "l": "Leukocyte - Myelocyte (Granulocyte) - Neutrophil (MMHCC)", "d": []}, {"i": "NCIT:C22593", "l": "Mouse Neutrophil", "d": []}]}
{"type": "biolink:Cell", "ic": "81.247621244257502", "identifiers": [{"i": "CL:0000797", "l": "alpha-beta intraepithelial T cell", "d": ["A mature alpha-beta T cell of the columnar epithelium of the gastrointestinal tract. Intraepithelial T cells often have distinct developmental pathways and activation requirements."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5163754", "l": "Erythrocytes.lytic resistant | Blood | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "ic": "90.82444074280258", "identifiers": [{"i": "CL:1000147", "l": "cardiac valve cell", "d": ["A cell that is part of a cardiac valve."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1182627", "l": "Epithelial cell of gingival part of viscerocranial mucosa", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5175005", "l": "Normoblasts | Blood cord | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1440144", "l": "Blasts.CD2", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0017473", "l": "Germ Line", "d": []}]}
{"type": "biolink:Cell", "ic": "84.75972595860604", "identifiers": [{"i": "CL:0004116", "l": "retinal ganglion cell C", "d": ["A retinal ganglion with cell medium cell bodies and medium to large dendritic fields."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0009106", "l": "medullary reticular cell", "d": ["A specialized fibroblast found in the medulla of lymph node."]}]}
{"type": "biolink:Cell", "ic": "87.120474278337809", "identifiers": [{"i": "CL:2000084", "l": "conjunctiva goblet cell", "d": ["Any goblet cell that is part of a conjunctiva."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0524817", "l": "Mossy Fibers, Hippocampal", "d": []}, {"i": "MESH:D019599", "l": "Mossy Fibers, Hippocampal", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5186011", "l": "Band form neutrophils | Fetus | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5667076", "l": "Autologous IL-7/CCL19-expressing Anti-GM2 CAR T Cells NIB-101", "d": []}, {"i": "NCIT:C186667", "l": "Autologous IL-7/CCL19-expressing Anti-GM2 CAR T Cells NIB-101", "d": ["A preparation of autologous T-lymphocytes that have been genetically modified to express a chimeric antigen receptor (CAR) targeting the tumor-associated antigen (TAA) ganglioside GM2 (GM2) and producing the immune regulators interleukin-7 (IL-7) and C-C motif chemokine 19 (CCL19) using PRIME (proliferation-inducing and migration-enhancing) technology, with potential immunostimulating and antineoplastic activities. Upon administration, autologous IL-7/CCL19-expressing anti-GM2 CAR T-cells NIB-101 target and bind to GM2-expressing tumor cells, thereby inducing selective toxicity in GM2-expressing tumor cells. In addition, as IL-7 promotes the proliferation and survival of T-cells and CCL19 enhances the migration of host T-cells and dendritic cells (DCs), the production of IL-7 and CCL19 by NIB-101 allows for enhanced trafficking and accumulation of the PRIME CAR-T cells and other endogenous immune cells, including T-cells and DCs in tumor tissues. This further activates the host immune system to induce anti-tumor immune responses to various cancer antigens and against tumor cells lacking the CAR target antigen. GM2, a type of glycosphingolipid, is overexpressed on the surface of many cancer cells, such as multiple myeloma (MM) cells and neuroblastoma cells."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1267819", "l": "Lymphocyte positive for both CD3 antigen and CD26 antigen", "d": []}, {"i": "SNOMEDCT:117520004", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C2826385", "l": "Umbilical Cord Blood-Derived Mesenchymal Stem Cells", "d": []}, {"i": "NCIT:C82688", "l": "Umbilical Cord Blood-Derived Mesenchymal Stem Cells", "d": ["Multipotent stem cells of mesenchymal origin isolated from umbilical cord blood. Umbilical cord blood-derived mesenchymal stem cells can differentiate into a variety of cell types including fibroblasts, osteoblasts, chondrocytes, myocytes, adipocytes, and endothelial cells."]}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "CL:0002211", "l": "type I muscle cell", "d": ["A slow muscle cell that has large amounts of myoglobin, stores energy as triglycerides, generates ATP by the oxidative method and is resistant to fatigue."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C4289974", "l": "Anti-CD22 CAR-expressing T Lymphocytes", "d": []}, {"i": "NCIT:C128556", "l": "Anti-CD22 CAR-expressing T Lymphocytes", "d": ["A preparation of human T-lymphocytes transduced with a recombinant viral vector encoding a chimeric T-cell receptor (chimeric antigen receptor or CAR) consisting of one or more binding domains targeting the tumor-associated antigen (TAA) CD22 and fused to one or more co-stimulatory, TCR-signaling domains, with potential immunostimulating and antineoplastic activities. Upon administration, the anti-CD22 CAR-expressing T-lymphocytes, express anti-CD22-CAR on their cell surfaces and bind to the CD22 antigen on tumor cell surfaces. Subsequently, CD22-expressing B-cells are lysed. CD22, a B-lineage-restricted, transmembrane phosphoglycoprotein, is expressed on malignant B-cells."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0597661", "l": "visual photoreceptor", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5170954", "l": "Leukocytes other | Fetus | Pleural fluid | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "UMLS:C2985477", "l": "Exocrine Pancreas Cell", "d": []}, {"i": "NCIT:C93173", "l": "Exocrine Pancreas Cell", "d": ["A pancreatic cell which either secretes digestive enzymes (acinar cell) or bicarbonate-rich fluid (ductal cell) via the pancreatic duct into the duodenum to assist in digestion."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1181542", "l": "Type II cell of paraganglion", "d": []}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "UMLS:C1513168", "l": "Metaplastic Apocrine Cell", "d": []}, {"i": "NCIT:C36882", "l": "Metaplastic Apocrine Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "80.869303025598512", "identifiers": [{"i": "CL:0010005", "l": "atrioventricular bundle cell", "d": ["A specialized cardiomyocyte that transmit signals from the AV node to the cardiac Purkinje fibers."]}]}
{"type": "biolink:Cell", "ic": "89.347505587204751", "identifiers": [{"i": "UMLS:C1880539", "l": "Epithelioid Osteoblast", "d": []}, {"i": "NCIT:C67121", "l": "Epithelioid Osteoblast", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1267986", "l": "Lymphocyte positive for CD99 antigen", "d": []}, {"i": "SNOMEDCT:117426008", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C4086978", "l": "iAPA-based Dendritic Cells/Cytotoxic T Lymphocytes", "d": []}, {"i": "NCIT:C123922", "l": "iAPA-based Dendritic Cells/Cytotoxic T Lymphocytes", "d": ["A cell-based product composed of dendritic cells (DCs) pulsed with tumor-associated antigens (TAAs) and devoid of the inhibitory effect of antigen presentation attenuators (iAPA) combined with cytotoxic T-lymphocytes (CTLs) (iAPA-DC/CTL), with potential immunostimulating and antineoplastic activities.  DCs are transduced with a viral vector containing small interfering RNAs (siRNAs) against APAs, which prevents the expression of APA genes and inhibits attenuation of antigen presentation. Upon administration of iAPA-DC/CTL, the DCs are able to efficiently present antigens to the immune system, stimulate the immune system against tumor-associated antigens (TAAs) and hyperactivate TAA-specific CTLs and T-helper cells. Also, the iAPA-based DCs inhibit the activity of the T-regulatory cells (Tregs), thereby abrogating their negative effect on CTL activation and preventing their immunosuppressive activity against TAAs. Altogether, this inhibits tumor cell proliferation. Additionally, the administered CTLs induce direct cancer cell lysis. APAs negatively regulate antigen presentation, activate Tregs and their immunosuppressive activity, affect inflammatory cytokine production by DCs, and negatively regulate the immunostimulatory activity of DCs; they have an overall inhibitory effect on the stimulation of the immune system."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002536", "l": "epithelial cell of amnion", "d": ["An epithelial cell that is part of the amnion."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1267886", "l": "Lymphocyte positive for CD19 antigen", "d": []}, {"i": "SNOMEDCT:116851009", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4267792", "l": "Cells.CD25+CD127-", "d": []}]}
{"type": "biolink:Cell", "ic": "65.20186355550635", "identifiers": [{"i": "CL:0000148", "l": "melanocyte", "d": ["A pigment cell derived from the neural crest. Contains melanin-filled pigment granules, which gives a brown to black appearance."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0683191", "l": "Ooblast", "d": []}]}
{"type": "biolink:Cell", "ic": "80.511444690059548", "identifiers": [{"i": "CL:0002665", "l": "otic fibrocyte", "d": ["A fibrocyte of the cochlea that has specialized structural and molecular adaptions."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0003045", "l": "M12 retinal ganglion cell", "d": ["A bistratified ganglion cell with larger, asymetric dendritic fields that terminate in S2 and S4."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C4724886", "l": "Autologous Mesenchymal Stem Cells-Poly Lactic-co-glycolic Acid", "d": []}, {"i": "NCIT:C148189", "l": "Autologous Mesenchymal Stem Cells-Poly Lactic-co-glycolic Acid", "d": ["A preparation of autologous bone marrow derived mesenchymal stem cells (MSC) that are seeded on biodegradable poly lactic-co-glycolic acid (PLGA)-containing polymer scaffolds, that can potentially be used for bone marrow engraftment. When administered into the bone lesion of the patient, the autologous MSC-PLGA can be used for bone marrow engraftment."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5216297", "l": "Nucleated cells|NCnc|Pt|Body fld", "d": []}]}
{"type": "biolink:Cell", "ic": "41.958733813699972", "identifiers": [{"i": "UMLS:C1513959", "l": "Neoplastic Epithelial Cell", "d": []}, {"i": "NCIT:C36753", "l": "Neoplastic Epithelial Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5418112", "l": "Haploidentical Natural Killer Cells K-NK002", "d": []}, {"i": "NCIT:C175232", "l": "Haploidentical Natural Killer Cells K-NK002", "d": ["A population of ex-vivo expanded and activated haploidentical donor-derived natural killer (NK) cells, with potential immunomodulating and antineoplastic activities. Upon administration prior to and following haploidentical hematopoietic cell transplantation, the haploidentical NK cells K-NK002 may induce an anti-tumor immune response and may exert cytotoxicity against tumor cells."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157312", "l": "CD14+CD16+CD59+ cells | Serum | Cell markers", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:1000445", "l": "myoepithelial cell of dilator pupillae", "d": ["A myoepithelial cell that is part of the dilatator pupillae."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1979677", "l": "Cells.CD81", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C4744782", "l": "Autologous MCPyV-specific HLA-A02-restricted TCR-transduced CD4+ and CD8+ T-cells FH-MCVA2TCR", "d": []}, {"i": "NCIT:C156382", "l": "Autologous MCPyV-specific HLA-A02-restricted TCR-transduced CD4+ and CD8+ T-cells FH-MCVA2TCR", "d": ["A preparation of autologous CD4+ and CD62L-expressing CD8+ T-cells transduced with a third generation lentiviral vector (LV) to express the high affinity T-cell receptor (TCR) A2 -MCC1, specific for the human leukocyte antigen (HLA)-A02-restricted Merkel cell polyomavirus (MCPyV; MCV) viral oncoprotein, with potential immunomodulating and antineoplastic activities. Upon reintroduction into the patient, the autologous MCPyV-specific HLA-A02-restricted TCR-transduced CD8+ and CD4+ T-cells FH-MCVA2TCR selectively bind to the KLLEIAPNC epitope (KLL epitope) within the MCPyV viral oncoprotein. This results in cytotoxic T-lymphocyte (CTL)-mediated elimination of tumor cells expressing the MCPyV viral oncoprotein. Additionally, tumor-specific HLA-A02-restricted CD4+ cells promote class I-restricted CD8+ proliferation, survival and effector functions by producing interleukin (IL)-2 and facilitating the activation of dendritic cells (DCs). MCPyV viral oncoprotein is highly expressed in Merkel cell carcinoma (MCC) caused by MCPyV."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5187200", "l": "RBC^Fetus", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:1000300", "l": "fibroblast of outer membrane of prostatic capsule", "d": ["A fibroblast that is part of the outer membrane of prostatic capsule."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5776716", "l": "Monocytes.CD14+CD16-", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002679", "l": "natural helper lymphocyte", "d": ["A lymphocyte found in adipose tissue that lacks lineage markers of other lymphocytes but is capable of mediating TH2 cytokine responses. This cell type is found in fat associated lymphoid clusters, proliferates in response to IL2 and produce large amounts of TH2 cytokines such as IL5, IL6 and IL13"]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2329995", "l": "Stratified amacrine cell of retina", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5173432", "l": "Monocytes | Body fluid | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "ic": "89.347505587204751", "identifiers": [{"i": "UMLS:C1519454", "l": "Spider Cell", "d": []}, {"i": "NCIT:C36742", "l": "Spider Cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4267785", "l": "Cells.CD27-IgD+", "d": []}]}
{"type": "biolink:Cell", "ic": "92.728541327098611", "identifiers": [{"i": "CL:0002208", "l": "brush cell of bronchus", "d": ["A brush cell found in the epithelium of bronchus."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1507335", "l": "Ciliated columnar lining cells", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1517530", "l": "Mouse Germ Cell", "d": []}, {"i": "NCIT:C24193", "l": "Mouse Germ Cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1254876", "l": "Polychromic Normoblast", "d": []}]}
{"type": "biolink:Cell", "ic": "78.96520244130248", "identifiers": [{"i": "UMLS:C1514013", "l": "Neoplastic Mature Ganglion Cell", "d": []}, {"i": "NCIT:C42084", "l": "Neoplastic Mature Ganglion Cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5221180", "l": "CTX001", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4267707", "l": "100 cells.CD3+TCR alpha beta+", "d": []}]}
{"type": "biolink:Cell", "ic": "78.96520244130248", "identifiers": [{"i": "CL:1000409", "l": "myocyte of sinoatrial node", "d": ["A muscle cell that is part of the sinoatrial node."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1267905", "l": "Lymphocyte positive for CD32 antigen", "d": []}, {"i": "SNOMEDCT:117576007", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5186014", "l": "Basophils | Fetus | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0945924", "l": "Cell positive for CD23 antigen", "d": []}, {"i": "SNOMEDCT:116755006", "d": []}]}
{"type": "biolink:Cell", "ic": "83.552982069901191", "identifiers": [{"i": "UMLS:C1709676", "l": "Primitive Skeletal Spindle Cell", "d": []}, {"i": "NCIT:C49171", "l": "Primitive Skeletal Spindle Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C4329333", "l": "Anti-LeY-CAR-transduced Autologous T-Lymphocytes", "d": []}, {"i": "NCIT:C132683", "l": "Anti-LeY-CAR-transduced Autologous T-Lymphocytes", "d": ["Genetically modified, autologous T-lymphocytes transduced with a retroviral vector encoding a chimeric antigen receptor (CAR) specific for the tumor-associated antigen (TAA) Lewis-Y (LeY), with potential immunomodulating and antineoplastic activities. Upon intravenous administration, anti-LeY-CAR-transduced autologous T-lymphocytes specifically target and induce selective toxicity in LeY-expressing tumor cells. LeY, a difucosylated carbohydrate antigen, is overexpressed by a variety of cancer cell types."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0682522", "l": "AGMK cell", "d": []}]}
{"type": "biolink:Cell", "ic": "70.673456348239", "identifiers": [{"i": "UMLS:C1515966", "l": "Anaplastic Large Lymphocyte", "d": []}, {"i": "NCIT:C37018", "l": "Anaplastic Large Lymphocyte", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2350623", "l": "Retinal Rod Cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2333515", "l": "Adipocyte of epicardial fat of right ventricle", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5178308", "l": "Promyelocytes | Cerebral spinal fluid | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5172503", "l": "Mesothelial cells | Body fluid | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C3847488", "l": "Cells.CD3-CD4+", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1184809", "l": "Primitive cardiac myocyte", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5235893", "l": "Bone Marrow-Derived Mononuclear Cells", "d": []}, {"i": "NCIT:C164011", "l": "Bone Marrow-Derived Mononuclear Cells", "d": ["A biological sample containing mononuclear cells isolated from the bone marrow of an experimental subject."]}]}
{"type": "biolink:Cell", "ic": "90.82444074280258", "identifiers": [{"i": "CL:0002269", "l": "vasoactive intestinal peptide secreting cell", "d": ["An endocrine cell that secretes vasoactive intestinal peptide."]}]}
{"type": "biolink:Cell", "ic": "86.236661114203869", "identifiers": [{"i": "CL:0002066", "l": "Feyrter cell", "d": ["A neuroendocrine cell found in the epithelium of the lungs and respiratory tract. This cell type is rounded or elliptical in shape, situated mainly in the basal part of the epithelium; regulates bronchial secretion, smooth muscle contraction, lobular growth, ciliary activity and chemoreception. Cell has an electron-lucent cytoplasm, contains numerous dense-cored vesicles with a clear halo between the core and the limiting membrane."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C0017527", "l": "Giant Cells, Foreign-Body", "d": []}, {"i": "NCIT:C12561", "l": "Foreign Body Giant Cell", "d": ["An assemblage of macrophages that become fused in an inflammatory response to the presence of exogenous material."]}, {"i": "MESH:D015743", "l": "Giant Cells, Foreign-Body", "d": []}, {"i": "SNOMEDCT:21386001", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4511891", "l": "Population of all plasma cells in portion of fluid", "d": []}, {"i": "SNOMEDCT:726508007", "d": []}]}
{"type": "biolink:Cell", "ic": "75.42073205405498", "identifiers": [{"i": "CL:0000120", "l": "granule cell", "d": ["A neuron of the vertebrate central nervous system that is small in size. This general class includes small neurons in the granular layer of the cerebellar cortex, cerebral cortex neurons that are not pyramidal cells and small neurons without axons found in the olfactory bulb."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5154482", "l": "Basophils | Pleural fluid | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:4023187", "l": "koniocellular cell", "d": ["A neuron with a small cell body that is located in a koniocellular layer of the lateral geniculate nucleus (LGN)."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1441375", "l": "Cells.total", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0229425", "l": "Primary sclerotic mastoid cell", "d": []}, {"i": "SNOMEDCT:57003005", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0011111", "l": "gonadotropin-releasing hormone neuron", "d": ["A neuroendocrine cell that secretes gonadotropin-releasing hormone (GnRH). A GnRH neuron is born in the nasal placode during embryonic development and migrates through the nose and forebrain to the hypothalamus. This cell regulates reproduction by secreting GnRH into the pituitary portal vessels to induce the release of gonadotropins into the general circulation."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157344", "l": "CD19 blasts | XXX | Cell markers", "d": []}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "CL:0002406", "l": "immature Vgamma2-positive thymocyte", "d": ["A double negative post-natal thymocyte that has a T cell receptor consisting of a gamma chain containing a Vgamma2 segment, and a delta chain. This cell type is CD4-negative, CD8-negative and CD24-positive."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C3652653", "l": "indium (111In) oxinate labelled cells", "d": []}]}
{"type": "biolink:Cell", "ic": "80.511444690059548", "identifiers": [{"i": "CL:0007003", "l": "preodontoblast", "d": ["Skeletogenic cell that has the potential to form an odontoblast, deposits predentine, and arises from a cranial neural crest cell."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002379", "l": "meningothelial cell", "d": ["A neurecto-epithelial cell found in the arachnoid villi of dura mater. This cell type facilitates flow of cerebrospinal fluid into the blood."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1518019", "l": "Low Grade Malignant Transitional Cell", "d": []}, {"i": "NCIT:C36839", "l": "Low Grade Malignant Transitional Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002110", "l": "B220-low CD38-positive naive B cell", "d": ["A B220-low CD38-positive naive B cell is a CD38-positive naive B cell that has the phenotype B220-low, CD38-positive, surface IgD-positive, surface IgM-positive, and CD27-negative, that has not yet been activated by antigen in the periphery."]}]}
{"type": "biolink:Cell", "ic": "84.128890093485552", "identifiers": [{"i": "CL:0002365", "l": "medullary thymic epithelial cell", "d": ["An epithelial cell of the medullary thymus. This cell type expresses a diverse range of tissue-specific antigens. This promiscuous gene expression is a cell-autonomous property of medullary epithelial cells and is maintained during the entire period of thymic T cell output."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5572421", "l": "Deep transitional cells | Urine sediment | Urinalysis", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1267837", "l": "B lymphocyte positive for CD19 antigen", "d": []}, {"i": "SNOMEDCT:115417009", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C3273206", "l": "Anti-mesothelin CIR mRNA-electroporated Autologous T Cells", "d": []}, {"i": "NCIT:C97038", "l": "Anti-mesothelin CIR mRNA-electroporated Autologous T Cells", "d": ["Autologous chimeric immune receptor (CIR) T cells transfected with anti-mesothelin chimeric T cell receptor mRNA, with potential antineoplastic activity. The anti-mesothelin mRNA encodes a single chain antibody variable fragment (ScFv), the intracellular CD 3 zeta T cell receptor domain and the 4-1BB (cd137) costimulatory domain. Upon intravenous administration, the anti-mesothelin CIR mRNA-electroporated autologous T cells may attach to cancer cells expressing mesothelin. This may stimulate the secretion of multiple cytokines and may result in cell lysis of mesothelin-expressing cancer cells. Mesothelin is a cell surface glycoprotein involved in cell adhesion and is overexpressed in many epithelial-derived cancers."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157299", "l": "CD13+CD33+ cells | Blood | Cell markers", "d": []}]}
{"type": "biolink:Cell", "ic": "87.120474278337809", "identifiers": [{"i": "UMLS:C1883046", "l": "Small Cuboidal Cell Resembling Fetal Hepatocyte", "d": []}, {"i": "NCIT:C60804", "l": "Small Cuboidal Cell Resembling Fetal Hepatocyte", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0806987", "l": "Mononuclear cells", "d": []}]}
{"type": "biolink:Cell", "ic": "90.82444074280258", "identifiers": [{"i": "CL:0000386", "l": "attachment cell", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0008010", "l": "cranial somatomotor neuron", "d": ["A cranial motor neuron whose soma is located in the midbrain andor hindbrain and which innervates the skeletal muscles of the eye or tongue."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0000706", "l": "choroid plexus epithelial cell", "d": ["Specialized ependymal cell that produces the cerebrospinal fluid from the blood and secretes it into the lumen of the brain and spinal chord."]}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "UMLS:C1708946", "l": "Activated Mature Gamma/Delta T-Lymphocyte with a Cytotoxic Phenotype", "d": []}, {"i": "NCIT:C45341", "l": "Activated Mature Gamma/Delta T-Lymphocyte with a Cytotoxic Phenotype", "d": ["A mature lymphocyte whose T cell receptor, a gamma polypeptide chain linked by a disulfide bridge to a delta polypeptide chain, has recognized specific foreign antigens and self MHC antigens.  This type of cell is most often found in the gut and epidermis."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0882793", "l": "Cells.CD14+CD16+CD59+", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157322", "l": "CD158 cells | XXX | Cell markers", "d": []}]}
{"type": "biolink:Cell", "ic": "50.164613618136443", "identifiers": [{"i": "UMLS:C4551752", "l": "Abnormal Lymphocyte cell", "d": []}, {"i": "NCIT:C36725", "l": "Abnormal Lymphocyte", "d": ["A lymphocyte characterized by a structural or functional abnormality."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:1001430", "l": "urethra urothelial cell", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002597", "l": "smooth muscle cell of bladder", "d": ["A smooth muscle cell of the bladder."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0009109", "l": "lymphatic endothelial cell of trabecula", "d": ["A lymphatic endothelial cell located in a lymph node trabecula."]}]}
{"type": "biolink:Cell", "ic": "69.721054312086878", "identifiers": [{"i": "UMLS:C0596993", "l": "Myeloid Progenitor Cells", "d": []}, {"i": "NCIT:C12552", "l": "Bone Marrow Myeloid Stem Cell", "d": ["A hematopoietic stem cell found in the bone marrow that is committed to form erythrocytes, megakaryocytes, and all leukocytes except lymphocytes."]}, {"i": "MESH:D023461", "l": "Myeloid Progenitor Cells", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0004237", "l": "fountain amacrine cell", "d": ["A retinal amacrine cell with a medium dendritic field and post-synaptic terminals in S1, S2, S3, and S4. This cell type releases the neurotransmitter gamma-aminobutyric acid (GABA)."]}]}
{"type": "biolink:Cell", "ic": "84.128890093485552", "identifiers": [{"i": "CL:1001432", "l": "kidney collecting duct intercalated cell", "d": []}]}
{"type": "biolink:Cell", "ic": "92.728541327098611", "identifiers": [{"i": "CL:1001135", "l": "arcuate artery cell", "d": []}]}
{"type": "biolink:Cell", "ic": "57.52914464125729", "identifiers": [{"i": "CL:0000163", "l": "endocrine cell", "d": ["A cell of an endocrine gland, ductless glands that secrete substances which are released directly into the circulation and which influence metabolism and other body functions."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:2000083", "l": "hair follicle dermal papilla cell of scalp", "d": ["Any hair follicle dermal papilla cell that is part of a scalp."]}]}
{"type": "biolink:Cell", "ic": "89.347505587204751", "identifiers": [{"i": "CL:0009116", "l": "progenitor cell of mammary luminal epithelium", "d": ["A progenitor cell with the potential to differentiate into luminal epithelial cells of mammary glands. In mouse, CD61 and c-kit were found to be coexpressed by the majority of, but not all, committed luminal progenitor cells."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1440268", "l": "CD19+Lambda+ cell", "d": []}, {"i": "SNOMEDCT:732278001", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002189", "l": "granular cell of epidermis", "d": ["A keratinocyte of the epidermis that is characterized by containing granules of keratohyalin and lamellar granules."]}]}
{"type": "biolink:Cell", "ic": "83.552982069901191", "identifiers": [{"i": "CL:0002375", "l": "Schwann cell precursor", "d": ["A giioblast cell that develops from a migratory neural crest cell. The SCP is embedded among neurons (axons) with minimal extracellular spaces separating them from nerve cell membranes and has no basal lamina. In rodents SCPs are the only cells in the Schwann cell linage that expresses Cdh19."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157252", "l": "CD11+CD18+ cells | White blood cells | Cell markers", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1507324", "l": "Cells.CD11b+HLA-DR+", "d": []}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "CL:0002539", "l": "aortic smooth muscle cell", "d": ["A smooth muscle cell of the aorta."]}]}
{"type": "biolink:Cell", "ic": "90.82444074280258", "identifiers": [{"i": "UMLS:C0231044", "l": "Structure of primordial sex cell", "d": []}, {"i": "NCIT:C33401", "l": "Primordial Germ Cell", "d": ["A mesodermal precursor of germ cells, detectable at four weeks of fetal development. It originates in the allantois and then migrates through the hindgut and into the genital ridge, where it proliferates and differentiates into an oogonia or spermatogonia cell."]}, {"i": "SNOMEDCT:23430009", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1440370", "l": "Cells.CD94", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5555562", "l": "Anti-GUCY2C CAR-T Cells", "d": []}, {"i": "NCIT:C179261", "l": "Anti-GUCY2C CAR-T Cells", "d": ["A preparation of T-lymphocytes that have been genetically modified to express a chimeric antigen receptor (CAR) targeting human guanylate cyclase 2C (GUCY2C; GCC; guanylyl cyclase C; heat-stable enterotoxin receptor; hSTAR), with potential immunostimulating and antineoplastic activities. Upon administration, anti-GUCY2C CAR-T cells target and bind to GUCY2C-expressing tumor cells, thereby inducing selective toxicity in GUCY2C-expressing tumor cells. GUCY2C, a transmembrane receptor expressed on intestinal epithelial cells, is overexpressed on certain tumors of the gastrointestinal (GI) tract."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5171770", "l": "Lymphoma cells | Blood | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5205406", "l": "Allogeneic CD34+-enriched and CD45RA-depleted PBSCs", "d": []}, {"i": "NCIT:C160621", "l": "Allogeneic CD34+-enriched and CD45RA-depleted PBSCs", "d": ["A preparation of donor-derived peripheral blood stem cells (PBSCs) that have been enriched with CD34-positive stem cells and have been depleted of CD45RA-positive cells, that can potentially be used for immune reconstitution purposes. CD45RA depletion results in a cellular product that contains a high amount of memory T-cells (Tm). Upon infusion of the allogeneic CD34+-enriched and CD45RA-depleted PBSCs after a hematopoietic cell transplantation (HCT), these cells provide Tm recovery and are able to prevent viral infections. The depletion of the CD45RA-positive cells reduces the risk of graft-versus-host disease (GvHD) upon infusion. CD45RA is expressed on naive T-cells (Tn), whereas Tm cells are CD45RA-negative. Tn cells have the potential to induce more severe GvHD than Tm cells."]}]}
{"type": "biolink:Cell", "ic": "79.246894609297499", "identifiers": [{"i": "UMLS:C1513755", "l": "Multivacuolated Lipoblast", "d": []}, {"i": "NCIT:C36973", "l": "Multivacuolated Lipoblast", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157443", "l": "CD3+CD4+CD28+HLA DR+ cells | Blood | Cell markers", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0000888", "l": "lymph node tingible body macrophage", "d": ["A lymph node macrophage found in the cortex of lymph nodes, in particular in and around the germinal centers, and that participates in phagocytosis of apoptotic B cells from the germinal centers."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5401610", "l": "CAP-1002", "d": []}]}
{"type": "biolink:Cell", "ic": "84.75972595860604", "identifiers": [{"i": "UMLS:C1707673", "l": "Dendritic Melanoma Cell", "d": []}, {"i": "NCIT:C53275", "l": "Dendritic Melanoma Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:1001286", "l": "inner medulla vasa recta descending limb cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1178808", "l": "Purkinje myocyte", "d": []}]}
{"type": "biolink:Cell", "ic": "71.88020023694385", "identifiers": [{"i": "UMLS:C1709177", "l": "Neoplastic Granulocyte", "d": []}, {"i": "NCIT:C43230", "l": "Neoplastic Granulocyte", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1440272", "l": "Cells.CD22+CD11c+", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:1000457", "l": "mesothelial cell of visceral peritoneum", "d": ["A mesothelial cell that is part of the visceral peritoneum."]}]}
{"type": "biolink:Cell", "ic": "69.25985915845861", "identifiers": [{"i": "UMLS:C1514934", "l": "Rhabdomyoblast", "d": []}, {"i": "NCIT:C36744", "l": "Rhabdomyoblast", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0427568", "l": "Platelet satellite", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1979086", "l": "Blasts.CD11a", "d": []}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "CL:0002215", "l": "type IIb muscle cell", "d": ["A type II muscle cell that contains a low content of myoglobin, relatively few mitochondria, relatively few blood capillaries and large amounts of glycogen. Type II B fibres are white, geared to generate ATP by anaerobic metabolic processes, not able to supply skeletal muscle fibres continuously with sufficient ATP, fatigue easily, split ATP at a fast rate and have a fast contraction velocity."]}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "CL:0002654", "l": "epithelial cell of stratum corneum of esophageal epithelium", "d": ["An epithelial cell of stratum corneum of esophageal epithelium."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4288077", "l": "Omidubicel", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0946056", "l": "Epithelial cells.extrarenal", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1516958", "l": "Mouse Erythroblast", "d": []}, {"i": "NCIT:C22565", "l": "Mouse Erythroblast", "d": []}]}
{"type": "biolink:Cell", "ic": "92.728541327098611", "identifiers": [{"i": "CL:0011013", "l": "motile sperm cell", "d": ["A sperm cell that is cabaple of motion (motility)."]}]}
{"type": "biolink:Cell", "ic": "77.488267285704651", "identifiers": [{"i": "CL:0002138", "l": "endothelial cell of lymphatic vessel", "d": ["A endothelial cell of a lymphatic vessel. The border of the oak leaf-shaped endothelial cell of initial lymphatics are joined by specialized buttons. The discontinuous feature of buttons distinguishes them from zippers in collecting lymphatics, but both types of junctions are composed of proteins typical of adherens junctions and tight junctions found in the endothelium of blood vessels. Buttons seal the sides of flaps of the oak leaf-shaped endothelial cell, leaving open the tips of flaps as routes for fluid entry without disassembly and reformation of intercellular junctions."]}]}
{"type": "biolink:Cell", "ic": "60.327366391955856", "identifiers": [{"i": "CL:0000458", "l": "serotonin secreting cell", "d": ["A cell type that secretes 5-Hydroxytryptamine (serotonin)."]}]}
{"type": "biolink:Cell", "ic": "81.648881485605159", "identifiers": [{"i": "CL:0000442", "l": "follicular dendritic cell", "d": ["A cell with extensive dendritic processes found in the B cell areas (primary follicles and germinal centers) of lymphoid tissue. They are unrelated to the dendritic cell associated with T cells. Follicular dendritic cells have Fc receptors and C3b receptors, but unlike other dendritic cells, they do not process or present antigen in a way that allows recognition by T cells. Instead, they hold antigen in the form of immune complexes on their surfaces for long periods and can present antigen to B cells during an immune response."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5187678", "l": "HUMAN CORD BLOOD HEMATOPOIETIC PROGENITOR CELL 500000000 in 25 mL INTRAVENOUS INJECTION", "d": []}]}
{"type": "biolink:Cell", "ic": "89.347505587204751", "identifiers": [{"i": "UMLS:C1882049", "l": "Neoplastic Epithelial Large Polygonal Cell", "d": []}, {"i": "NCIT:C61000", "l": "Neoplastic Epithelial Large Polygonal Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "62.009648551699165", "identifiers": [{"i": "UMLS:C1513932", "l": "Neoplastic Blast", "d": []}, {"i": "NCIT:C37064", "l": "Neoplastic Blast", "d": []}]}
{"type": "biolink:Cell", "ic": "80.511444690059548", "identifiers": [{"i": "CL:0000811", "l": "CD8-positive, alpha-beta thymocyte", "d": ["An immature alpha-beta T cell that is located in the thymus and is CD8-positive and CD4-negative."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5691292", "l": "Colonic M Cells", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5205974", "l": "Gene-edited Autologous Neoantigen-targeted NeoTCR-P1 T-cells", "d": []}, {"i": "NCIT:C161651", "l": "Gene-edited Autologous Neoantigen-targeted NeoTCR-P1 T-cells", "d": ["A preparation of autologous CD4- and CD8-positive T-lymphocytes that have been engineered with site-specific nucleases to suppress the expression of most endogenous forms of the T-cell receptor (TCR) and promote expression of a single, native TCR targeting a neoepitope that is presented on the surface of a patient's tumor cells, with potential immunostimulating and antineoplastic activities. Upon reintroduction into the patient, the gene-edited autologous neoantigen-targeted NeoTCR-P1 T-cells recognize and bind to tumor cells expressing the targeted neoantigen, resulting in a cytotoxic T-lymphocyte (CTL)-mediated immune response against the patient's tumor cells."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4316898", "l": "Segmented basophil", "d": []}, {"i": "SNOMEDCT:30061004", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C0333805", "l": "Macrocytic erythrocyte", "d": []}, {"i": "NCIT:C13112", "l": "Macrocytic Red Blood Cell", "d": ["An abnormally large red blood cell occurring mainly in anemias (as pernicious anemia), also called megalocyte.  Lack of vitamin B12 and folic acid could also cause macrocytes. (NCI)"]}, {"i": "SNOMEDCT:259681001", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5555088", "l": "Allogeneic Invariant Natural Killer T-cells agenT-797", "d": []}, {"i": "NCIT:C178501", "l": "Allogeneic Invariant Natural Killer T-cells agenT-797", "d": ["A preparation of allogeneic, off-the shelf, natural killer T-cells (NKTs) expressing an invariant (alpha, beta) T-cell receptor (iNKTs), with potential immunomodulating and antineoplastic activities. Upon administration of allogeneic iNKT agenT-797, the invariant T-cell receptor (TCR) and natural-killer group 2, member D receptor (NKG2D; KLRK1; natural killer cell activating receptor group 2D) expressed by these cells recognize CD1d-restricted lipid ligands and stress ligands, which are expressed on certain tumor cells. These receptor-ligand interactions may induce the secretion of large amounts of various pro-inflammatory cytokines, including interferon gamma (IFN-g), and activate the immune system against tumor cells. Additionally, iNKTs directly target and lyse tumor cells."]}]}
{"type": "biolink:Cell", "ic": "67.782924002860781", "identifiers": [{"i": "CL:0000319", "l": "mucus secreting cell", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C0333854", "l": "Large cleaved cell", "d": []}, {"i": "NCIT:C32923", "l": "Large Cleaved Cell", "d": ["An activated lymphocyte with a diameter of about 12 micrometers, a nucleus with deep folds or clefts and clumped chromatin."]}, {"i": "SNOMEDCT:72549000", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5170930", "l": "Leukocytes | Fetus | Pleural fluid | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1881195", "l": "Indium In 111-Labeled Autologous Peripheral Blood Mononuclear Cells", "d": []}, {"i": "NCIT:C67085", "l": "Indium In 111-Labeled Autologous Peripheral Blood Mononuclear Cells", "d": ["A preparation of autologous peripheral blood mononuclear cells (PBMCs) radiolabeled with indium In 111 with radioisotopic activity. Autologous PBMCs are isolated, expanded ex vivo, radiolabeled with indium In 111, and then infused back into the patient. Gamma scintigraphy may then be used to image gamma ray-emitting indium In 111 PBMCs localized in lymphoma tissue."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5700403", "l": "Allogeneic EBV-specific CTLs ATA129", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5669194", "l": "Anti-BCMA CAR-NK Cells", "d": []}, {"i": "NCIT:C184309", "l": "Anti-BCMA CAR-NK Cells", "d": ["A preparation of umbilical cord blood (CB)-derived natural killer cells (NKs) expressing a chimeric antigen receptor (CAR) specific for the tumor-associated antigen (TAA) B-cell maturation antigen (BCMA; tumor necrosis factor receptor superfamily member 17; TNFRSF17), with potential immunomodulating and antineoplastic activities. Upon transfusion, the anti-BCMA CAR-NK cells recognize, bind to and induce selective cytotoxicity in BCMA-expressing tumor cells. BCMA, a receptor for both a proliferation-inducing ligand (APRIL) and B-cell activating factor (BAFF), is a member of the tumor necrosis factor receptor superfamily (TNFRSF). BCMA is found on the surfaces of plasma cells, is overexpressed on malignant plasma cells and plays a key role in plasma cell proliferation and survival."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2330822", "l": "Goblet cell of epithelium of crypt of Lieberkuhn of large intestine", "d": []}]}
{"type": "biolink:Cell", "ic": "72.370703631459492", "identifiers": [{"i": "UMLS:C1516965", "l": "Keratinized squamous cell of esophagus", "d": []}, {"i": "NCIT:C32542", "l": "Esophageal Squamous Cell", "d": ["A flat, scale-like epithelial cell that lines the upper and middle third of the esophageal lumen."]}]}
{"type": "biolink:Cell", "ic": "69.653168928076894", "identifiers": [{"i": "CL:0000082", "l": "epithelial cell of lung", "d": ["An epithelial cell of the lung."]}]}
{"type": "biolink:Cell", "ic": "51.976932497122434", "identifiers": [{"i": "CL:0000213", "l": "lining cell", "d": ["A cell within an epithelial cell sheet whose main function is to act as an internal or external covering for a tissue or an organism."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2331294", "l": "Interdental cell of cochlea", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:4028003", "l": "alveolar capillary type 2 endothelial cell", "d": ["An alveolar capillary endothelial cell that is located proximally to alveolar capillary type 1 endothelial cells and in close apposition to alveolar type 1 epithelial cells (also known as type I pneumocytes)."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4740238", "l": "Spermatozoa.excess residual cytoplasm", "d": []}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "CL:0000582", "l": "neutrophilic metamyelocyte", "d": ["A neutrophil precursor in the granulocytic series, being a cell intermediate in development between a myelocyte and the band form neutrophil. The protein synthesis seen in earlier stages decreases or stops; the nucleus becomes indented where the indentation is smaller than half the distance to the farthest nuclear margin; chromatin becomes coarse and clumped; specific granules predominate while primary granules are rare; and the cytoplasm becomes amphophilic like that of a mature granulocyte. This cell type is integrin alpha-M-positive, CD13-negative, CD15-positive, CD16-positive, CD33-positive, CD24-positive, fMLP receptor-negative and has expression of C/EBP-a, C/EBP-e, PU.1 transcription factor, lactotransferrin, myeloperoxidase and neutrophil gelatinase associated lipocalin."]}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "CL:1001580", "l": "hippocampal glial cell", "d": ["A glial cell that is part of the hippocampus."]}]}
{"type": "biolink:Cell", "ic": "71.423552501508112", "identifiers": [{"i": "CL:0000808", "l": "DN4 thymocyte", "d": ["A thymocyte that has the phenotype CD4-negative, CD8-negative, CD44-negative, CD25-negative, and pre-TCR-positive."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C0225668", "l": "Clara cell", "d": []}, {"i": "NCIT:C13143", "l": "Club Cell", "d": ["A rounded, club-shaped, nonciliated cell found in between ciliated cells in the epithelium of respiratory and terminal bronchioles. It has a secretory function."]}, {"i": "SNOMEDCT:77810002", "d": []}]}
{"type": "biolink:Cell", "ic": "84.128890093485552", "identifiers": [{"i": "CL:0002405", "l": "gamma-delta thymocyte", "d": ["A post-natal thymocyte expressing components of the gamma-delta T cell receptor. This cell type is always double-negative (i.e. CD4-negative, CD8-negative)."]}]}
{"type": "biolink:Cell", "ic": "55.362644158735939", "identifiers": [{"i": "CL:0000108", "l": "cholinergic neuron", "d": ["A neuron that uses acetylcholine as a vesicular neurotransmitter."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0000078", "l": "peridermal cell", "d": []}]}
{"type": "biolink:Cell", "ic": "59.390126070323255", "identifiers": [{"i": "CL:0007009", "l": "prechondroblast", "d": ["Skeletogenic cell that has the potential to develop into a chondroblast; and arises from neural crest, meseosdermal and notochordal and connective tissue cells."]}]}
{"type": "biolink:Cell", "ic": "75.751739371353352", "identifiers": [{"i": "UMLS:C0035316", "l": "Retinal Ganglion Cells", "d": []}, {"i": "NCIT:C12642", "l": "Retinal Ganglion Cell", "d": ["An output neuron in the retina that receives visual signals from photoreceptors via interneurons, and transmits the information to the thalamus, hypothalamus, and superior colliculus of the brain through the optic nerve."]}, {"i": "MESH:D012165", "l": "Retinal Ganglion Cells", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2924225", "l": "Cells.CD45+CD103+", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2333121", "l": "Enterocyte of epithelium of intestinal villus", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1179445", "l": "Nonkeratinized cell of epidermis", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5706663", "l": "Exagamglogene Autotemcel", "d": []}]}
{"type": "biolink:Cell", "ic": "75.105493098994543", "identifiers": [{"i": "CL:0000008", "l": "migratory cranial neural crest cell", "d": ["Cell that is part of the migratory cranial neural crest population. Migratory cranial neural crest cells develop from premigratory cranial neural crest cells and have undergone epithelial to mesenchymal transition and delamination."]}]}
{"type": "biolink:Cell", "ic": "81.648881485605159", "identifiers": [{"i": "CL:0000439", "l": "prolactin secreting cell", "d": ["A peptide hormone cell that secretes prolactin."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4300404", "l": "Cells.chromosome region 17p13.1 deletion", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2326176", "l": "Set of serotoninergic cells", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5177784", "l": "Polymorphonuclear cells | XXX | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C3178845", "l": "Wharton Jelly Cells", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C3172534", "l": "Cells.CD3+CD5-", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C4055455", "l": "Anti-mesothelin iCasp9M28z CAR-transduced Autologous T Lymphocytes", "d": []}, {"i": "NCIT:C121782", "l": "Anti-mesothelin iCasp9M28z CAR-transduced Autologous T Lymphocytes", "d": ["Genetically modified, autologous T-lymphocytes transduced with a retroviral vector encoding a chimeric antigen receptor (CAR) specific for mesothelin linked to the signaling domains for the co-stimulatory molecules CD28 and CD3 zeta, as well as the suicide gene inducible caspase 9 (iCasp9 or iC9), with potential immunomodulating and antineoplastic activities. Upon intravenous administration, anti-mesothelin iCasp9M28z CAR-transduced autologous T lymphocytes specifically target and kill mesothelin-expressing tumor cells. iCasp9 consists of a human FK506 drug-binding domain with an F36V mutation (FKBP12-F36V) linked to human caspase 9. If the administered T-cells lead to unacceptable side effects, a dimerizing agent can be administered, which binds to the FKBP12-F36V drug-binding domain and activates caspase 9, resulting in the apoptosis of the administered T-cells. Mesothelin, a tumor-associated antigen, is overexpressed in a variety of cancer cell types."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4072767", "l": "Cells.4q12 chromosome region rearrangements", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C4725828", "l": "Allogeneic Most Closely HLA-matched Adenovirus-specific Cytotoxic T Lymphocytes", "d": []}, {"i": "NCIT:C150553", "l": "Allogeneic Most Closely HLA-matched Adenovirus-specific Cytotoxic T Lymphocytes", "d": ["A population of off the shelf, closely human leukocyte antigen (HLA)-matched allogeneic, ex vivo-expanded cytotoxic T-lymphocytes (CTLs) specifically reactive to human adenovirus (Ad), with potential immunomodulating and anti-adenoviral activities. Upon administration, the allogeneic most closely HLA-matched Ad-specific CTLs may reconstitute Ad-specific CTL responses in patients at risk of developing Ad infections either following allogeneic stem cell transplantation or in Ad-infected immunocompromised hosts. The anti-adenoviral CTLs are provided by a third party donor and not by the allogeneic stem cell transplant donor."]}]}
{"type": "biolink:Cell", "ic": "83.552982069901191", "identifiers": [{"i": "CL:0000593", "l": "androgen secreting cell", "d": ["A steroid hormone secreting cell that secretes androgen."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5446539", "l": "Autologous CLL1-CAR-CD28-expressing T-lymphocytes", "d": []}, {"i": "NCIT:C175458", "l": "Autologous CLL1-CAR-CD28-expressing T-lymphocytes", "d": ["A preparation of autologous T-lymphocytes expressing a chimeric antigen receptor (CAR) specific for the tumor-associated antigen (TAA) C-type-lectin-like molecule-1 (CLL1; C-type lectin domain family 12 member A; CLEC12A) linked to the CD28 co-stimulatory signaling domain, with potential immunomodulating and antineoplastic activities. Upon administration, the autologous CLL1-CAR-CD28-expressing T-lymphocytes specifically target and bind to CLL1-expressing tumor cells. This induces selective toxicity in tumor cells that express the CLL1 antigen. CLL1, a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily, is overexpressed in leukemic stem cells (LSCs) and plays an important role in disease progression and relapse for myeloid malignancies."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157262", "l": "CD117 blasts | XXX | Cell markers", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2325536", "l": "H III cell of retina", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C3640224", "l": "Allogeneic Adenovirus-specific Cytotoxic T Lymphocytes", "d": []}, {"i": "NCIT:C101796", "l": "Allogeneic Adenovirus-specific Cytotoxic T Lymphocytes", "d": ["A population of allogeneic cytotoxic T-lymphocytes (CTLs) specifically reactive to human adenovirus (Ad) with potential immunomodulating and anti-adenoviral activities. Upon immunoprophylactic adoptive cell therapy, infusion of allogeneic Ad-specific CTLs may help reconstitute Ad-specific CTL responses in patients at risk of developing Ad infections after allogeneic stem cell transplant or in Ad-infected immunocompromised hosts. These allogeneic Ad-specific CTLs are prepared by multiple rounds of stimulation with donor peripheral blood mononuclear cells and lymphoblastoid cell lines that have been transduced with Ad5f35, a recombinant adenoviral vector carrying no transgene."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1257793", "l": "Lymphatic Endothelial Cells", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002284", "l": "type X enteroendocrine cell", "d": ["An enteroendocrine cell found in the fundus and pylorus; this cell type has dense round secretory granules that contain ghrelin."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002583", "l": "subcutaneous preadipocyte", "d": ["A preadipocyte that is part of subcutaneous tissue."]}]}
{"type": "biolink:Cell", "ic": "90.82444074280258", "identifiers": [{"i": "UMLS:C1709173", "l": "Neoplastic Epithelioid Neuroendocrine Cell", "d": []}, {"i": "NCIT:C48593", "l": "Neoplastic Epithelioid Neuroendocrine Cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5220616", "l": "Transitional cells|Urine/Urine sed", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0005008", "l": "macular hair cell", "d": ["An auditory hair cell located in the macula that is sensitive to auditory stimuli."]}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "UMLS:C1708906", "l": "Malignant Small Osteoblast", "d": []}, {"i": "NCIT:C53956", "l": "Malignant Small Osteoblast", "d": []}]}
{"type": "biolink:Cell", "ic": "87.120474278337809", "identifiers": [{"i": "CL:0000307", "l": "tracheal epithelial cell", "d": ["An epithelial cell found in the trachea."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5171960", "l": "Malignant cells | Body fluid | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5216275", "l": "Monocytes|NCnc|Pt|Periton fld", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1440273", "l": "Cells.CD22+CD19+", "d": []}]}
{"type": "biolink:Cell", "ic": "71.423552501508112", "identifiers": [{"i": "CL:0000656", "l": "primary spermatocyte", "d": ["A diploid cell that has derived from a spermatogonium and can subsequently begin meiosis and divide into two haploid secondary spermatocytes."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5549477", "l": "Spermatozoa Motile | Urine | Fertility testing", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0003038", "l": "M7-OFF retinal ganglion cell", "d": ["An M7 retinal ganglion cells with synaptic terminals in S2 and is depolarized by decreased illumination of their receptive field center"]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0229615", "l": "Pyroninophilic lymphoid cell", "d": []}, {"i": "SNOMEDCT:20472006", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5416854", "l": "DB-001", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2323033", "l": "Type EC1 enteroendocrine cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5382943", "l": "Interferon-gamma producing HLA-B8 Cytomegalovirus specific CD8 cells | Blood | Cell markers", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2325187", "l": "Lens epithelial cell", "d": []}]}
{"type": "biolink:Cell", "ic": "82.532694649739099", "identifiers": [{"i": "UMLS:C1512330", "l": "Hallmark Cell", "d": []}, {"i": "NCIT:C39679", "l": "Hallmark Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "90.82444074280258", "identifiers": [{"i": "CL:0000715", "l": "embryonic crystal cell", "d": ["A crystal cell that derives from the embryonic head mesoderm."]}]}
{"type": "biolink:Cell", "ic": "85.457082654197222", "identifiers": [{"i": "UMLS:C1510783", "l": "Adenocarcinoma Spindle Cell", "d": []}, {"i": "NCIT:C37108", "l": "Adenocarcinoma Spindle Cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0882836", "l": "CD3+CD8+ cell", "d": []}, {"i": "SNOMEDCT:732280007", "d": []}]}
{"type": "biolink:Cell", "ic": "66.791794193372041", "identifiers": [{"i": "CL:0000826", "l": "pro-B cell", "d": ["A progenitor cell of the B cell lineage, with some lineage specific activity such as early stages of recombination of B cell receptor genes, but not yet fully committed to the B cell lineage until the expression of PAX5 occurs."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C3900001", "l": "Autologous Cytomegalovirus-specific Cytotoxic T-lymphocytes", "d": []}, {"i": "NCIT:C116732", "l": "Autologous Cytomegalovirus-specific Cytotoxic T-lymphocytes", "d": ["A population of autologous cytotoxic-T lymphocytes (CTLs) specifically reactive to the herpes virus cytomegalovirus (CMV) with potential immunomodulating and antiviral activities. Upon administration with the autologous CMV-specific CTLs, these CTLs lyse CMV-infected cells, thereby preventing or decreasing the occurrence of CMV viral disease, or reducing the amount of antiviral drug therapy needed to eradicate CMV."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5417851", "l": "Autologous Anti-B7-H3/CD19 CAR T-cells SCRI-CARB7H3(s)x19", "d": []}, {"i": "NCIT:C171318", "l": "Autologous Anti-B7-H3/CD19 CAR T-cells SCRI-CARB7H3(s)x19", "d": ["A preparation of autologous CD4+ and CD8+ T-lymphocytes lentivirally transduced to express a chimeric antigen receptor (CAR) targeting the immunoregulatory protein B7-homologue 3 (B7-H3, CD276) and the tumor-associated antigen (TAA) CD19, and containing, as of yet undisclosed co-stimulatory signaling domains, and a truncated form of the human epidermal growth factor receptor (EGFRt), with potential immunostimulating and antineoplastic activities. Upon administration, anti-B7-H3/CD19 CAR T-cells target and bind to both B7-H3 on T-cells and CD19 on tumor cells. This crosslinks T-cells and tumor cells, and induces selective toxicity in B7-H3/CD19-expressing tumor cells. B7-H3, a type I transmembrane protein and a member of the B7 co-stimulatory protein superfamily, is overexpressed on certain tumor cell types and on various immune cells. It promotes the activation of T cells. CD19, a transmembrane phosphoglycoprotein expressed on the surface of cells in the B lineage, are often overexpressed on malignant B-cells. Devoid of both ligand binding domains and tyrosine kinase activity, the expressed EGFRt both facilitates in vivo detection of the administered, transduced T-cells and can promote elimination of those cells through a cetuximab-induced antibody dependent cellular cytotoxicity (ADCC) response."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5173495", "l": "Mononuclear cells | Cerebral spinal fluid | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "ic": "90.82444074280258", "identifiers": [{"i": "CL:4023050", "l": "L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex", "d": ["An intratelencephalic-projecting glutamatergic neuron with a soma found in L6 of the primary motor cortex. These cells are short untufted pyramidal cells, which could be stellate or inverted."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C2349140", "l": "WT1-Sensitized Allogeneic T-Lymphocytes", "d": []}, {"i": "NCIT:C74091", "l": "WT1-Sensitized Allogeneic T-Lymphocytes", "d": ["A population of allogeneic T-cells sensitized with Wilms tumor 1 (WT1) antigen with potential immunostimulatory and antineoplastic activities. Upon administration, WT1-sensitized T cells may bind to and lyse WT1-expressing tumor cells. WT1 antigen, a zinc finger DNA-binding protein acting as a transcriptional activator or repressor depending on the cellular or chromosomal context, is overexpressed in leukemic cells and in a vast number of nonhematological solid tumors."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1181298", "l": "Dark chief cell of parathyroid gland", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5216324", "l": "Unidentified cells|NCnc|Pt|Plr fld", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2327049", "l": "Non-keratinized squamous cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5184395", "l": "Unidentified cells | Blood | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5219007", "l": "Erythrocytes|PrThr|Urine", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5669566", "l": "Tenvumestrocel", "d": []}, {"i": "NCIT:C184827", "l": "Tenvumestrocel", "d": []}]}
{"type": "biolink:Cell", "ic": "92.728541327098611", "identifiers": [{"i": "CL:0000762", "l": "nucleated thrombocyte", "d": ["A nucleated blood cell involved in coagulation, typically seen in birds and other non-mammalian vertebrates."]}]}
{"type": "biolink:Cell", "ic": "78.185623981295834", "identifiers": [{"i": "CL:0000205", "l": "thermoreceptor cell", "d": ["A cellular receptor which mediates the sense of temperature. Thermoreceptor cells in vertebrates are mostly located under the skin. In mammals there are separate types of thermoreceptors for cold and for warmth and pain receptor cells which detect cold or heat extreme enough to cause pain."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5170943", "l": "Leukocytes | Urine | Urinalysis", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5156214", "l": "Burr cells | Cerebral spinal fluid | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1254948", "l": "C5 Lymphocyte", "d": []}]}
{"type": "biolink:Cell", "ic": "83.552982069901191", "identifiers": [{"i": "CL:0002049", "l": "fraction C precursor B cell", "d": ["A precursor B cell that is CD45R-positive, CD43-positive, CD24-positive, and BP-positive. Intracellularly expression of surrogate light chain, Rag1 and Rag2, TdT, occurs while there is no expression of mu heavy chain."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002142", "l": "dark cell of eccrine sweat gland", "d": ["A cell pyramidal in shape, with their broad ends facing and forming the greater extent of the lining of the main lumen. Secretes glycoproteins associated with mucus."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0009085", "l": "colony forming unit – Hill cell", "d": ["An adult endothelial progenitor cell characterised in vivo by homing to ischemic sites and paracrine support of angiogenesis. They may form discrete colonies."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5212874", "l": "Monocytes.HLA-DR", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002600", "l": "smooth muscle cell of trachea", "d": ["A smooth muscle cell of the trachea."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1183980", "l": "Chromaffin cell of ovary", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157491", "l": "CD34 blasts | Bone marrow | Cell markers", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:4033008", "l": "vein endothelial cell of respiratory system", "d": ["A(n) vein endothelial cell that is part of a(n) respiratory system."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C4055459", "l": "Anti-GPC3-CAR Autologous T Lymphocytes", "d": []}, {"i": "NCIT:C121638", "l": "Anti-GPC3-CAR Autologous T Lymphocytes", "d": ["A preparation of autologous T-lymphocytes that have been genetically modified to express a chimeric antigen receptor (CAR) specific for glypican-3 (GPC3), with potential immunostimulating and antineoplastic activities. Upon administration, anti-GPC3-CAR autologous T-lymphocytes specifically target and bind to GPC3-expressing tumor cells, resulting in tumor cell lysis. GPC3, a heparan sulfate proteoglycan and a member of the glypican family, is overexpressed on certain tumor cell types while minimally expressed in normal, healthy cells; GPC3 plays an important role in cellular proliferation and differentiation."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5446871", "l": "Welgenaleucel", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002517", "l": "interrenal epinephrin secreting cell", "d": ["An interrenal chromaffin cell found in teleosts that contain small, homogeneous electron-lucent granules that are separated from the vesicular membrane by a visible halo."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5174613", "l": "Neutrophils | Blood cord | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5691289", "l": "Tonsillar M Cells", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002402", "l": "Peyer's patch B cell", "d": ["A resting mature B cell within the Peyer's patch that is CD19-positive, B220-positive, IgM-positive, AA4-negative, CD23-positive, CD43-negative, and CD5-negative."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C3824982", "l": "Pancreatic acinar cells--Cancer", "d": []}]}
{"type": "biolink:Cell", "ic": "90.82444074280258", "identifiers": [{"i": "CL:1001589", "l": "duodenum glandular cell", "d": ["Glandular cell of duodenal epithelium. Example: Enterocytes, Goblet cells, enteroendocrine cells; Paneth cells; M cells; Brunner's gland cell."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1979182", "l": "Blasts.CD179a", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157529", "l": "CD3-CD57+ cells | Tissue and Smears | Cell markers", "d": []}]}
{"type": "biolink:Cell", "ic": "81.247621244257502", "identifiers": [{"i": "UMLS:C1514073", "l": "Neoplastic Prolymphocyte", "d": []}, {"i": "NCIT:C37182", "l": "Neoplastic Prolymphocyte", "d": []}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "UMLS:C1709162", "l": "Neoplastic Adrenal Cortical Clear Cell", "d": []}, {"i": "NCIT:C48362", "l": "Neoplastic Adrenal Cortical Clear Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5666915", "l": "Anti-KLK2 CAR-T Cells JNJ-75229414", "d": []}, {"i": "NCIT:C183544", "l": "Anti-KLK2 CAR-T Cells JNJ-75229414", "d": ["A preparation of T-lymphocytes that have been genetically modified to express a chimeric antigen receptor (CAR) targeting human kallikrein-2 (hK2; KLK2) expressed on tumor cells, with potential immunostimulating and antineoplastic activities. Upon administration, anti-KLK2 CAR-T cells JNJ-75229414 target and bind to KLK2-expressing tumor cells, thereby inducing selective toxicity in KLK2-expressing tumor cells. KLK2 is overexpressed in certain tumors, including prostate adenocarcinoma."]}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "UMLS:C1709192", "l": "Neoplastic Parathyroid Gland Water-Clear Cell", "d": []}, {"i": "NCIT:C48625", "l": "Neoplastic Parathyroid Gland Water-Clear Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "UMLS:C1883048", "l": "Small Melanoma Cell", "d": []}, {"i": "NCIT:C62401", "l": "Small Melanoma Cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4510900", "l": "Blast cell positive for CD1 antigen", "d": []}, {"i": "SNOMEDCT:724246004", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1440390", "l": "Cells.hyperdiploid", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:4029003", "l": "somatic nurse-like cell", "d": ["A gamete-nursing cell that derives from the somatic tissues of the gonad (del Pino, 2021)."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C2698062", "l": "Alpha-Galactosylceramide-Pulsed Autologous Dendritic Cells", "d": []}, {"i": "NCIT:C78489", "l": "Alpha-Galactosylceramide-Pulsed Autologous Dendritic Cells", "d": ["A cancer vaccine comprised of autologous dendritic cells (DCs) pulsed with the marine sponge glycolipid alpha-galactosylceramide (alpha-GalCer) with potential immunostimulatory and antimetastatic activities. Upon administration, alpha-galactosylceramide-pulsed autologous dendritic cells may result in the activation and proliferation of a subset of endogenous natural killer T (NKT) cells, B cells, and CD4+ and CD8+ T cells, and the production of interferon-gamma and interleukin-12; these cascade events may result in a T helper-1 cell-biased proinflammatory antitumor immune response. The NKT cell ligand alpha-GalCer was originally isolated from the marine sponge Agelas mauritianusis."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157557", "l": "CD4+CD95+ cells | Blood | Cell markers", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5161798", "l": "Cytoplasmic CD22 blasts | Blood | Cell markers", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1181299", "l": "Clear chief cell of parathyroid cell", "d": []}, {"i": "NCIT:C33267", "l": "Parathyroid Gland Clear Cell", "d": ["A large cell of the parathyroid gland. It has abundant clear cytoplasm packed with glycogen and a basal nucleus."]}]}
{"type": "biolink:Cell", "ic": "64.45299868619928", "identifiers": [{"i": "CL:0000117", "l": "CNS neuron (sensu Vertebrata)", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157360", "l": "CD19+Kappa+ cells | Blood | Cell markers", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C3272995", "l": "Lymphoma TAA-specific Cytotoxic T Lymphocytes", "d": []}, {"i": "NCIT:C96736", "l": "Lymphoma TAA-specific Cytotoxic T Lymphocytes", "d": ["A population of autologous cytotoxic T lymphocytes (CTLs) with potential immunomodulating and antitumor activities. White blood cells are grown ex-vivo and are exposed to dendritic cells (DCs) loaded with lymphoma tumor associated antigens (TAAs); the TAA-specific CTLs are further expanded ex-vivo before being introduced into the patient. Upon infusion with TAA-specific CTLs, these CTLs may help activate tumor-specific CTL responses in the patient, thereby specifically killing TAA-expressing cancer cells and eventually inhibiting tumor cell proliferation."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0486534", "l": "Cells other than spermatozoa", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1545228", "l": "Cells.CD3-CD57+", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C4085971", "l": "Anti-Epidermal Growth Factor Receptor 2 Antibody Expressing Pluripotent Killer T-Lymphocytes", "d": []}, {"i": "NCIT:C125633", "l": "Anti-Epidermal Growth Factor Receptor 2 Antibody Expressing Pluripotent Killer T-Lymphocytes", "d": ["A specific population of pluripotent killer (PIK) T-cells that have been induced to express high levels of antibodies against human epidermal growth factor receptor 2 (ERBB2; HER2), with potential antitumor activity. Although the exact mechanism(s) of action through which PIK-HER2 cells exert their effects has yet to be elucidated, upon infusion, these cells secrete antibodies targeting HER2 expressed on the surface of tumor cells. This may inhibit HER2-dependent signaling, which may lead to inhibition of cellular proliferation and differentiation. Additionally, these cells may stimulate the host immune system to mount both a highly-specific cytotoxic T-lymphocyte (CTL) response and antibody-dependent cell cytotoxicity (ADCC) directed against HER2-overexpressing tumors, which leads to tumor cell lysis. HER2 is a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases and is frequently overexpressed in solid tumors."]}]}
{"type": "biolink:Cell", "ic": "76.10017597303252", "identifiers": [{"i": "CL:0000878", "l": "central nervous system macrophage", "d": ["A tissue-resident macrophage found in the central nervous system."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:4030043", "l": "matrix D1 medium spiny neuron", "d": ["A DRD1-expressing medium spiny neuron that is part of a matrix compartment of dorsal striatum."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1184931", "l": "External limiting cell of vestibular epithelium", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1979669", "l": "Cells.CD19+IgG+", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5178319", "l": "Pronormoblasts | Blood | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1267897", "l": "Lymphocyte positive for CD25 antigen", "d": []}, {"i": "SNOMEDCT:116844000", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1522254", "l": "Ovary - Theca Cell (MMHCC)", "d": []}, {"i": "NCIT:C22666", "l": "Mouse Theca Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "86.236661114203869", "identifiers": [{"i": "CL:0011003", "l": "magnocellular neurosecretory cell", "d": ["A neurosecretory neuron residing mainly in the hypothalamic supraoptic and paraventricular nuclei and in a number of smaller accessory cell groups between these two nuclei, that is capable of secreting the hormones oxytocin or vasopressin, and sometimes both, into the systemic circulation."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5555034", "l": "Anti-MSLN CAR-T Cells LCAR-M23", "d": []}, {"i": "NCIT:C178439", "l": "Anti-MSLN CAR-T Cells LCAR-M23", "d": ["A preparation of T-lymphocytes that have been genetically modified to express a chimeric antigen receptor (CAR) specific for the human tumor-associated antigen (TAA) mesothelin (MSLN), with potential immunomodulating and antineoplastic activities. Upon administration, the anti-MSLN CAR-T cells LCAR-M23 specifically target and kill MSLN-expressing tumor cells. Mesothelin, a cell surface glycoprotein involved in cell adhesion, is overexpressed in a variety of cancer cell types."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1511740", "l": "Decidual cell", "d": []}, {"i": "NCIT:C32429", "l": "Decidual Cell", "d": ["An endometrial fibroblast that differentiates during pregnancy in response to the implanting embryo by accumulating lipid and glycogen. It is polygonal, possesses a large, vesicular nucleus and is believed to secrete placental prolactin. The decidual cells form a tightly adherent, massive cellular matrix that first surrounds the implanting embryo and later occupies most of the endometrium."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5442137", "l": "BCMA-specific CAR-expressing T lymphocytes", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C4522300", "l": "CD19CAR-CD28-CD3zeta-EGFRt-expressing Tn/mem-enriched T-lymphocytes", "d": []}, {"i": "NCIT:C133073", "l": "CD19CAR-CD28-CD3zeta-EGFRt-expressing Tn/mem-enriched T-lymphocytes", "d": ["A preparation of genetically modified lymphocytes comprised of CD62L-positive naïve and memory T-cells (Tn/mem), that are transduced ex vivo with a self-inactivating (SIN) lentiviral vector expressing a hinge-optimized chimeric antigen receptor (CAR) specific for the CD19 antigen and containing CD28 and CD3 zeta signaling domains, and a truncated form of the human epidermal growth factor receptor (EGFRt), with potential immunostimulating and antineoplastic activities. Upon isolation of peripheral blood lymphocytes (PBLs), transduction of the CD62L-positive T-lymphocytes, expansion ex vivo and administration, the CD19R(EQ)-CD28-CD3zeta-EGFRt-expressing Tn/mem-enriched T-cells target CD19-expressing tumor cells, thereby inducing selective toxicity in CD19-expressing tumor cells. CD19 antigen is a B-cell specific cell surface antigen expressed in all B-cell lineage malignancies.  Devoid of both ligand binding domains and tyrosine kinase activity, EGFRt both facilitates in vivo detection of the administered T-cells and can promote elimination of those cells upon a cetuximab-induced antibody dependent cellular cytotoxicity response. Tn/mem T-cells include naïve T-cells, central memory T-cells (Tcm) and stem cell memory T-cells (Tscm). CD19R(EQ) contains two point mutations in the immunoglobulin (Ig) G4 spacer region, thereby preventing recognition of the CAR by Fc receptors (FcRs)."]}]}
{"type": "biolink:Cell", "ic": "80.869303025598512", "identifiers": [{"i": "CL:1000495", "l": "small intestine goblet cell", "d": ["A goblet cell that is part of the small intestine."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1267833", "l": "Lymphocyte positive for both CD3 antigen and CD8 antigen", "d": []}, {"i": "SNOMEDCT:116725004", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4510884", "l": "Blast cell positive for CD11c antigen", "d": []}, {"i": "SNOMEDCT:724308009", "d": []}]}
{"type": "biolink:Cell", "ic": "72.577556932535018", "identifiers": [{"i": "CL:4023120", "l": "cochlea auditory hair cell", "d": ["An auditory hair cell found in the cochlea."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1541584", "l": "Autologous Expanded Mesenchymal Stem Cells OTI-010", "d": []}, {"i": "NCIT:C2534", "l": "Autologous Expanded Mesenchymal Stem Cells OTI-010", "d": ["Multipotent self-renewing adherent non-hematopoietic stromal cells harvested from a patient's bone marrow and grown in vitro. When injected back into the patient, autologous expanded mesenchymal stem cells OTI-010 may differentiate into various mesenchyme-derived cell types and, in some instances, may augment bone marrow engraftment after whole-body irradiation."]}]}
{"type": "biolink:Cell", "ic": "89.347505587204751", "identifiers": [{"i": "UMLS:C1522160", "l": "Leukocyte - Myelocyte (Granulocyte) (MMHCC)", "d": []}, {"i": "NCIT:C22590", "l": "Mouse Granulocyte", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4518162", "l": "Population of all immature spermatozoa in portion of fluid", "d": []}, {"i": "SNOMEDCT:725438007", "d": []}]}
{"type": "biolink:Cell", "ic": "90.82444074280258", "identifiers": [{"i": "CL:0002670", "l": "type 1 otic fibrocyte", "d": ["An otic fibrocyte that underlies the stria vascularis and is part of a mesenchymal gap junction network that regulates ionic homeostasis of the endolymph."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1512099", "l": "Dyskeratotic Keratinocyte", "d": []}, {"i": "NCIT:C36746", "l": "Dyskeratotic Keratinocyte", "d": []}]}
{"type": "biolink:Cell", "ic": "81.247621244257502", "identifiers": [{"i": "UMLS:C1709468", "l": "Parathyroid Gland Parenchymal Cell", "d": []}, {"i": "NCIT:C48257", "l": "Parathyroid Gland Parenchymal Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "73.124874125835319", "identifiers": [{"i": "UMLS:C0028944", "l": "Oligodendroglia", "d": []}, {"i": "NCIT:C12618", "l": "Oligodendrocyte", "d": ["A type of large glial cell located in the central nervous system that produces myelin as its main function."]}, {"i": "MESH:D009836", "l": "Oligodendroglia", "d": []}, {"i": "SNOMEDCT:66254009", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5177470", "l": "Plasma cells/100 leukocytes | Body fluid | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "ic": "90.82444074280258", "identifiers": [{"i": "UMLS:C1512549", "l": "Hyperchromatic Megakaryocyte", "d": []}, {"i": "NCIT:C37049", "l": "Hyperchromatic Megakaryocyte", "d": []}]}
{"type": "biolink:Cell", "ic": "74.516770421031836", "identifiers": [{"i": "UMLS:C1516393", "l": "Centrocyte-Like Cell", "d": []}, {"i": "NCIT:C37001", "l": "Centrocyte-Like Cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4510886", "l": "Blast cell positive for CD127 antigen", "d": []}, {"i": "SNOMEDCT:724302005", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002501", "l": "type D1 enteroendocrine cell", "d": ["A P/D1 enteroendocrine cell that is argyrophilic and stores vasoactive intestinal polypeptide."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5449009", "l": "Abecma", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157523", "l": "CD3-CD19+ cells | Blood | Cell markers", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002348", "l": "CD27-low, CD11b-high natural killer cell, mouse", "d": ["A CD27-low, CD11b-high natural killer cell that has a higher threshold of activation due to higher expression of inhibitory receptors."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5177460", "l": "Plasma cells with abnormal marker pattern | Bone marrow | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C4524911", "l": "3D-expanded Placenta-derived Cells PLX-R18", "d": []}, {"i": "NCIT:C133823", "l": "3D-expanded Placenta-derived Cells PLX-R18", "d": ["A population of proprietary, off-the-shelf, three-dimensional (3D)-expanded, allogeneic placenta-derived stromal cells that can potentially be used to increase hematopoietic recovery from hematological disorders or after a hematopoietic stem cell transplant (HSCT). Upon intramuscular (IM) injection of placental expanded (PLX)-R18, these cells secrete a range of specific hematopoietic, regenerative proteins depending on their in vivo environment. The secreted proteins are involved in maintenance, renewal, proliferation, differentiation, and mobilization of hematopoietic progenitor cells (HPCs), and include, but are not limited to, granulocyte colony-stimulating factor (GCSF), monocyte chemoattractant protein-1 (MCP-1/CCL2), MCP-3 (CCL7), interleukin-6 (IL-6), and IL-8. This increases the number of colony-forming hematopoietic progenitors in the bone marrow, regenerates the bone marrow hematopoietic cells, and elevates and restores blood cell production."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5667170", "l": "Sizavaleucel", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0684115", "l": "macroblast of Naegeli", "d": []}]}
{"type": "biolink:Cell", "ic": "84.128890093485552", "identifiers": [{"i": "CL:0000454", "l": "epinephrine secreting cell", "d": ["A cell capable of producing epinephrine. Epiniphrine is synthesized from norepiniphrine by the actions of the phenylethanolamine N-methyltransferase enzyme, which is expressed in the adrenal glands, androgenic neurons, and in other cell types."]}]}
{"type": "biolink:Cell", "ic": "87.120474278337809", "identifiers": [{"i": "CL:0000530", "l": "primary neuron (sensu Teleostei)", "d": ["A neuron that develops during the early segmentation stages in teleosts, before the neural tube is formed."]}]}
{"type": "biolink:Cell", "ic": "76.46797986554256", "identifiers": [{"i": "CL:0000650", "l": "mesangial cell", "d": ["A cell type that encapsulates the capillaries and venules in the kidney. This cell secretes mesangial matrix that provides the structural support for the capillaries."]}]}
{"type": "biolink:Cell", "ic": "67.782924002860781", "identifiers": [{"i": "CL:0000083", "l": "epithelial cell of pancreas", "d": ["An epithelial cell of the pancreas."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0010014", "l": "type II pinealocyte", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5691155", "l": "LTF-303", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5171962", "l": "Malignant cells | Pericardial fluid | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0444242", "l": "Amniotic cell specimen", "d": []}, {"i": "SNOMEDCT:258563002", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4696700", "l": "Cells.CD19+CD27+", "d": []}]}
{"type": "biolink:Cell", "ic": "92.728541327098611", "identifiers": [{"i": "UMLS:C1514188", "l": "Pochon ES Cell Line", "d": []}, {"i": "NCIT:C20284", "l": "Pochon ES Cell Line", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1440053", "l": "Abnormal blood cells.CD20", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5216191", "l": "Basophils|NCnc|Pt|Body fld", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5180576", "l": "Segmented neutrophils | Cerebral spinal fluid | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:1000302", "l": "fibroblast of papillary layer of dermis", "d": ["A fibroblast that is part of the papillary layer of dermis."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2323406", "l": "Mononuclear cytotrophoblast cell", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C0026610", "l": "Motor Neurons, Gamma", "d": []}, {"i": "NCIT:C12646", "l": "Gamma Motor Neuron", "d": ["A type of motor neuron, found in the ventral horn of the spinal cord, that innervates intrafusal muscle fibers of neuromuscular spindles to help regulate skeletal muscle tone."]}, {"i": "MESH:D009047", "l": "Motor Neurons, Gamma", "d": []}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "UMLS:C1518999", "l": "Peripheral Blood Stem Cells", "d": []}, {"i": "NCIT:C12946", "l": "Peripheral Blood Stem Cell", "d": ["An immature (progenitor) cell circulating in the peripheral blood.  It has the capacity for replication and differentiation to mature blood cells."]}, {"i": "MESH:D000072916", "l": "Peripheral Blood Stem Cells", "d": []}, {"i": "SNOMEDCT:419583006", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1444184", "l": "Entire cleidoic ovum", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C3830403", "l": "Donor Regulatory T-lymphocytes", "d": []}, {"i": "NCIT:C111894", "l": "Donor Regulatory T-lymphocytes", "d": ["Donor-derived regulatory T-cells (Tregs), with potential immunomodulating activity.  Tregs are a subset of CD4+ T cells that express high levels of CD25 (interleukin 2 receptor) and the transcription factor Foxp3. The donor CD4+CD25+ Tregs modulate immune responses and may induce tolerance to allogeneic organ transplants, such as hematopoietic stem cell transplants (HSCTs), thereby preventing graft-versus-host disease (GVHD)."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1441143", "l": "Reticulocytes.mid", "d": []}]}
{"type": "biolink:Cell", "ic": "73.239986017158159", "identifiers": [{"i": "UMLS:C1512478", "l": "Hodgkin Cell", "d": []}, {"i": "NCIT:C37021", "l": "Hodgkin Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "81.247621244257502", "identifiers": [{"i": "UMLS:C1514174", "l": "Pleomorphic Lymphocyte", "d": []}, {"i": "NCIT:C36995", "l": "Pleomorphic Lymphocyte", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0000324", "l": "metanephric mesenchyme stem cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1267831", "l": "Lymphocyte positive for both CD3 antigen and CD56 antigen", "d": []}, {"i": "SNOMEDCT:117522007", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5222946", "l": "CD3- CD16+ cells/100 cells in bone marrow", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5173063", "l": "Micromegakaryocytes | Blood | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "ic": "70.99638707280991", "identifiers": [{"i": "CL:0002086", "l": "specialized cardiac myocyte", "d": ["A cardiac myocyte that is an excitable cells in the myocardium, specifically in the conducting system of heart."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157231", "l": "CD1 cells | Blood | Cell markers", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4329369", "l": "Autologous Cytokine-induced Killer Cells", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5216238", "l": "Leukocytes|NCnc|Pt|Periton fld", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0013485", "l": "Embryonal Carcinoma Stem Cells", "d": []}, {"i": "MESH:D054278", "l": "Embryonal Carcinoma Stem Cells", "d": []}]}
{"type": "biolink:Cell", "ic": "92.728541327098611", "identifiers": [{"i": "CL:1001285", "l": "vasa recta descending limb cell", "d": ["A cell that is part of some vasa recta descending limb."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002283", "l": "ecto-epithelial cell of viscerocranial mucosa", "d": ["An epithelial cell of the mucosa associated with facial skeleton."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1180240", "l": "Endothelial cell of postcapillary venule of lymph node", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C4745321", "l": "Young Autologous Tumor-infiltrating Lymphocytes", "d": []}, {"i": "NCIT:C156481", "l": "Young Autologous Tumor-infiltrating Lymphocytes", "d": ["A preparation of autologous young tumor infiltrating lymphocytes (TILs), that are isolated from the patient's tumor tissue and minimally cultured ex vivo, with potential antineoplastic and immunomodulating activities. Upon re-administration of the young TILs, the TILs re-infiltrate the tumor, recognize the tumor cells and initiate tumor cell lysis. This inhibits tumor cell growth."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C4727012", "l": "Autologous CD8+ SLC45A2-specific T Lymphocytes", "d": []}, {"i": "NCIT:C153083", "l": "Autologous CD8+ SLC45A2-specific T Lymphocytes", "d": ["A preparation of autologous CD8+ T lymphocytes targeting SLC45A2, a melanoma-associated antigen, with potential immunomodulating and antineoplastic activities. Following peripheral blood mononuclear cell (PBMC) collection and ex vivo expansion of SLC45A2-specific cytotoxic T-lymphocytes (CTLs), the autologous CD8+ SLC45A2-specific CTLs are re-infused into the patient, where they target and lyse SLC45A2-expressing tumor cells. While SLC45A2 is expressed by approximately 80% of cutaneous melanomas, its expression is limited in mature normal melanocytes, allowing high tumor selectivity and reduced potential for autoimmune toxicity."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1523992", "l": "Leukocyte - Monocyte - Macrophage - Histiocyte (MMHCC)", "d": []}, {"i": "NCIT:C22588", "l": "Mouse Histiocyte", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1656735", "l": "Cells.CD9+CD41+", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157540", "l": "CD4+CD25-CD127+ cells | Blood | Cell markers", "d": []}]}
{"type": "biolink:Cell", "ic": "70.99638707280991", "identifiers": [{"i": "UMLS:C1515971", "l": "Anaplastic T-Lymphocyte", "d": []}, {"i": "NCIT:C39678", "l": "Anaplastic T-Lymphocyte", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1267958", "l": "Lymphocyte positive for CD66A antigen", "d": []}, {"i": "SNOMEDCT:117399005", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1978609", "l": "Cells.CD3+CD57+", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0333821", "l": "Micromyeloblast", "d": []}, {"i": "SNOMEDCT:19651007", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1441142", "l": "Reticulocytes.mature", "d": []}]}
{"type": "biolink:Cell", "ic": "81.247621244257502", "identifiers": [{"i": "CL:1001593", "l": "parathyroid glandular cell", "d": ["Glandular cell of parathyroid epithelium. Example: Parathyroid chief cell and parathyroid oxyphil cells."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1525453", "l": "Cells.CD19+CD33+", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5555592", "l": "Personalized Neoantigen-specific T-lymphocytes NEO-PTC-01", "d": []}, {"i": "NCIT:C179294", "l": "Personalized Neoantigen-specific T-lymphocytes NEO-PTC-01", "d": ["A preparation of autologous, personalized tumor neoantigen-specific T-lymphocytes, with potential immunostimulating and antineoplastic activities. The T-cells are derived from the patients' peripheral blood mononuclear cells (PBMCs) and are primed and activated against tumor-specific neoantigens that are expressed on the patient's tumor cells or in the tumor microenvironment (TME), and expanded ex vivo. Upon administration, the autologous neoantigen-specific T-lymphocytes NEO-PTC-01 recognize and bind to tumor cells expressing the targeted neoantigens, resulting in a cytotoxic T-lymphocyte (CTL)-mediated immune response against the patient's tumor cells."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5554950", "l": "Autologous Anti-BCMA CAR T-cells spCART-269", "d": []}, {"i": "NCIT:C178325", "l": "Autologous Anti-BCMA CAR T-cells spCART-269", "d": ["A preparation of autologous T-lymphocytes that have been genetically engineered to express a chimeric antigen receptor (CAR) targeting the human tumor-associated antigen (TAA) B-cell maturation antigen (BCMA; tumor necrosis factor receptor superfamily member 17; TNFRSF17; CD269), with potential immunostimulating and antineoplastic activities. Upon administration, the autologous anti-BCMA CAR T-cells spCART-269 recognize and induce selective toxicity against BCMA-expressing tumor cells. BCMA, a tumor-specific antigen and a receptor for both a proliferation-inducing ligand (APRIL) and B-cell activating factor (BAFF), is a member of the tumor necrosis factor receptor superfamily (TNFRSF) and plays a key role in plasma cell survival. BCMA is found on the surfaces of plasma cells and is overexpressed on malignant plasma cells."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5556555", "l": "Autologous Anti-GFRa4 CAR-TCR-zeta-4-1BB-expressing T-cells", "d": []}, {"i": "NCIT:C180681", "l": "Autologous Anti-GFRa4 CAR-TCR-zeta-4-1BB-expressing T-cells", "d": ["A preparation of autologous T-lymphocytes that have been transduced with a lentiviral vector to express a chimeric antigen receptor (CAR) consisting of an anti-glial-derived neurotrophic factor (GDNF) family receptor alpha 4 (GFRa4) single chain variable fragment (scFv), coupled to the zeta chain of the human T-cell receptor (TCR/CD3zeta) and the co-stimulatory molecule 4-1BB (CD137), with potential immunostimulating and antineoplastic activities. Upon re-introduction into the patient, the autologous anti-GFRa4 CAR-TCR-zeta-4-1BB-expressing T-cells target and bind to GFRa4-expressing tumor cells. This results in a cytotoxic T-lymphocyte (CTL) response against GFRa4-expressing tumor cells, resulting in tumor cell lysis. GFRa4 is highly expressed in metastatic medullary thyroid cancer (MTC) and also normally expressed in parafollicular cells within the thyroid and thymus."]}]}
{"type": "biolink:Cell", "ic": "63.561493752554874", "identifiers": [{"i": "CL:0000094", "l": "granulocyte", "d": ["A leukocyte with abundant granules in the cytoplasm."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1440424", "l": "Cells.XXX", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2736926", "l": "Cells.CD10+FMC7+", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2736932", "l": "Cells.CD3+CD45+", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C3652916", "l": "chondrocytes, autologous", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1370091", "l": "Cells.CD11+CD18+", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1515141", "l": "T-Prolymphocyte", "d": []}, {"i": "NCIT:C33927", "l": "T-Prolymphocyte", "d": ["A medium sized round lymphocyte in the T-lymphocyte series, intermediate between the T-lymphoblast and the mature T-cell."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1440366", "l": "Cells.CD9", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0282542", "l": "Cells, Immobilized", "d": []}, {"i": "MESH:D018914", "l": "Cells, Immobilized", "d": []}]}
{"type": "biolink:Cell", "ic": "73.476395680690302", "identifiers": [{"i": "UMLS:C1514099", "l": "Neoplastic Spindle-Shaped to Round Cell", "d": []}, {"i": "NCIT:C37123", "l": "Neoplastic Spindle-Shaped to Round Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "UMLS:C4085194", "l": "Conventional Dendritic Cell", "d": []}, {"i": "NCIT:C123782", "l": "Conventional Dendritic Cell", "d": ["A subset of dendritic cells that are derived from myeloid precursors. They express toll-like receptors 2 and 4 and secrete interleukin-12."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2328107", "l": "Nephrocyte", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0683194", "l": "Male gonocyte", "d": []}]}
{"type": "biolink:Cell", "ic": "88.140761698499901", "identifiers": [{"i": "CL:4023023", "l": "L5,6 neurogliaform lamp5 GABAergic interneuron (Mmus)", "d": ["A lamp 5 GABAergic cortical interneuron with neurogliaform morphology with a soma found in L5,6. L5,6 NGC lamp5 have deep afterhyperpolarization (AHP) but narrow action potentials (APs). Unlike other deep neurogliaform cells (which are caudal ganglionic eminence (CGE) derived), L5,6 NGC lamp5 cells are medial ganglionic eminence (MGE)-derived"]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C0018497", "l": "Inner Auditory Hair Cells", "d": []}, {"i": "NCIT:C32805", "l": "Inner Hair Cell of the Organ of the Corti", "d": ["A cell situated on the inner most layer of the basilar membrane of the cochlea. Each cell has multiple, sensitive strands called stereocilia. In the resting state the stereocilia are leaning on each other in a conical bundle and touch the tectorial membrane. When the cochlea moves in response to sound, a slight shearing force occurs between the basilar and tectorial membranes, the stereocilia bend and send electrical impulses to the brain via the eighth cranial nerve."]}, {"i": "MESH:D006199", "l": "Hair Cells, Auditory, Inner", "d": []}, {"i": "SNOMEDCT:11520008", "d": []}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "UMLS:C1709172", "l": "Neoplastic Epithelioid Fibrohistiocytic Cell", "d": []}, {"i": "NCIT:C49080", "l": "Neoplastic Epithelioid Fibrohistiocytic Cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4263667", "l": "T-cell naive & memory & effector (CD27 and CD45RA) subsets", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5172358", "l": "Megakaryocytes | Bone marrow | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C4727680", "l": "Expanded Cord Blood Stem Cells Mixed with Engineered Human Endothelial Cells AB-110", "d": []}, {"i": "NCIT:C150135", "l": "Expanded Cord Blood Stem Cells Mixed with Engineered Human Endothelial Cells AB-110", "d": ["A population of ex vivo expanded, CD34-positive-enriched hematopoietic progenitor cells (HPCs), which are derived from allogeneic human umbilical cord blood (UCB), and are co-cultured and expanded with a proprietary preparation of human endothelial cells (ECs), which are genetically modified with an adenovirus (Ad) vector that includes the Ad E4 region that encodes the ORF1 (E4ORF1) gene, that can be used for transplantation. Upon transplantation of the expanded cord blood stem cells mixed with engineered human ECs AB-110, the UCB-derived cells can differentiate into a variety of cell types and promote blood cell recovery. Compared to bone marrow transplants, these HPCs demonstrate a decreased risk of causing graft-versus-host disease (GvHD), increase survival and enhance the potential for transplant and engraftment in any given patient as there is no need for a matched donor. Compared to HPCs alone, inclusion of the ECs increases blood stem cell count, enhances engraftment potential and increases the chances for blood cell recovery, thereby further increasing the potential for a successful cord blood transplantation. Insertion of the Ad E4ORF1 gene enhances survival and replication of the ECs ex vivo, preserves the ECs' vascular functions and improves the ability of the ECs to secrete angiocrines, which promotes stem cell proliferation and increases engraftment."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5184401", "l": "Unidentified cells | Synovial fluid | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:2000058", "l": "calvarial osteoblast", "d": ["Any osteoblast that is part of a skull."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4696638", "l": "Cells.CD4+CD25+CD45RO+CD127Low+", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C4744501", "l": "M1 Macrophage", "d": []}, {"i": "NCIT:C156004", "l": "M1 Macrophage", "d": ["A macrophage that expresses CD80 and CD86 on the cell surface, produces high levels of interleukin (IL)-8 and IL-12 and converts arginine to nitric oxide. These cells promote inflammation."]}]}
{"type": "biolink:Cell", "ic": "90.82444074280258", "identifiers": [{"i": "CL:0001062", "l": "effector memory CD8-positive, alpha-beta T cell, terminally differentiated", "d": ["A CD8-positive, alpha beta memory T cell with the phenotype CD45RA-positive, CD45RO-negative, and CCR7-negative."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5163442", "l": "Eosinophils | Pericardial fluid | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1507326", "l": "Cells.CD158", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5238462", "l": "Fas Ligand-treated Allogeneic Mobilized Peripheral Blood Cells", "d": []}, {"i": "NCIT:C167326", "l": "Fas Ligand-treated Allogeneic Mobilized Peripheral Blood Cells", "d": ["A donor graft derived from allogeneic filgrastim (granulocyte-colony stimulating factor; G-CSF)-mobilized peripheral blood cells (MPBC) that have been incubated with the recombinant human Fas ligand (FasL) APO010 ex vivo, and that can potentially be used for immune reconstitution purposes. The incubation of the hematopoietic stem cell graft with the apoptotic mediator Fas ligand (FasL) selectively induces apoptosis of mature T-cells which express high levels of Fas receptor, such as T stem cell memory (TSCM), T central memory (TCM), and T effector memory (TEM) cells and the pro-inflammatory T-helper cells (Th) Th1 and Th17 subsets while sparing CD34-positive stem and progenitor cells. Upon washing and further ex vivo preparations, and upon allogeneic hematopoietic stem cell transplantation (HSCT) with the FasL-treated allogeneic MPBCs, these cells provide hematopoietic cell recovery, preserve the graft-versus-leukemia (GvL) effects, and may prevent graft-versus-host disease (GvHD)."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0545063", "l": "P.B. osteoclast", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1440371", "l": "Cells.CD95", "d": []}]}
{"type": "biolink:Cell", "ic": "81.247621244257502", "identifiers": [{"i": "CL:4023076", "l": "Martinotti neuron", "d": ["An interneuron that has Martinotti morphology. These interneurons are scattered throughout various layers of the cerebral cortex, sending their axons up to the cortical layer I where they form axonal arborization."]}]}
{"type": "biolink:Cell", "ic": "84.75972595860604", "identifiers": [{"i": "CL:0002305", "l": "epithelial cell of distal tubule", "d": ["An epithelial cell of the distal convoluted tubule of the kidney that helps regulate systemic levels of potassium, sodium, calcium, and pH."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:4023128", "l": "rostral periventricular region of the third ventricle KNDy neuron", "d": ["a KNDy neuron that is located in the rostral periventricular region of the third ventricle."]}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "UMLS:C2986568", "l": "Neoplastic Eosinophilic Spindle Cell", "d": []}, {"i": "NCIT:C94551", "l": "Neoplastic Eosinophilic Spindle Cell", "d": ["A spindle-shaped neoplastic cell with eosinophilic and granular, often abundant cytoplasm."]}]}
{"type": "biolink:Cell", "ic": "90.82444074280258", "identifiers": [{"i": "CL:0001044", "l": "effector CD4-positive, alpha-beta T cell", "d": ["A CD4-positive, alpha-beta T cell with the phenotype CCR7-negative, CD45RA-positive."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5382747", "l": "CD107a+b expressing HLA-A2 Cytomegalovirus specific CD8 cells | Blood | Cell markers", "d": []}]}
{"type": "biolink:Cell", "ic": "68.888616052091592", "identifiers": [{"i": "UMLS:C1514084", "l": "Neoplastic Small B-Lymphocyte", "d": []}, {"i": "NCIT:C38702", "l": "Neoplastic Small B-Lymphocyte", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5770492", "l": "SynKIR-110", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0000886", "l": "nasal and broncial associated lymphoid tissue macrophage", "d": ["A mucosa-associated lymphoid tissue macrophage found in the nasal and bronchial mucosa-associated lymphoid tissues."]}]}
{"type": "biolink:Cell", "ic": "70.290762085176738", "identifiers": [{"i": "CL:0000568", "l": "amine precursor uptake and decarboxylation cell", "d": ["A cell that originates in the neural crest, that has certain cytochemical and ultrastructural characteristics and is found scattered throughout the body; types include melanocytes, the cells of the chromaffin system, and cells in the hypothalamus, hypophysis, thyroid, parathyroids, lungs, gastrointestinal tract, and pancreas. This cell type concentrates the amino acid precursors of certain amines and decarboxylate them, forming amines that function as regulators and neurotransmitters. This cell type produces substances such as epinephrine, norepinephrine, dopamine, serotonin, enkephalin, somatostatin, neurotensin, and substance P, the actions of which may affect contiguous cells, nearby groups of cells, or distant cells, thus functioning as local or systemic hormones. The name is an acronym for amine precursor uptake and decarboxylation cell."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:1000085", "l": "stratified non keratinized epithelial stem cell", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0009011", "l": "transit amplifying cell of colon", "d": ["A rapidly proliferating population of cells that differentiate from stem cells of the intestinal crypt of the colon. Stem cells located in the crypts of Lieberkühn give rise to proliferating progenitor or transit amplifying cells that differentiate into the four major epithelial cell types. These include columnar absorptive cells or enterocytes, mucous secreting goblet cells, enteroendocrine cells and paneth cells."]}]}
{"type": "biolink:Cell", "ic": "83.552982069901191", "identifiers": [{"i": "CL:0000476", "l": "thyrotroph", "d": ["A basophil cell of the anterior pituitary that produces thyroid stimulating hormone, thyrotrophin. This cell type is elongated, polygonal and lie in clusters towards the adenohypophyseal center."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0000953", "l": "preBCR-negative large pre-B-II cell", "d": ["A pre-BCR-negative large pre-B-II cell is a large pre-B-II cell that is pre-B cell receptor-negative, composed of surrogate light chain protein (SL), which is composed of VpreB and Lambda 5/14.1, in complex with immunoglobulin mu heavy chain (IgHmu), on the cell surface, and lack a DNA rearrangement of immunoglobulin light chain genes."]}]}
{"type": "biolink:Cell", "ic": "78.695011174409487", "identifiers": [{"i": "CL:0000553", "l": "megakaryocyte progenitor cell", "d": ["The earliest cytologically identifiable precursor in the thrombocytic series. This cell is capable of endomitosis and lacks expression of hematopoieitic lineage markers (lin-negative)."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:4033055", "l": "airway submucosal gland duct ciliated cell", "d": ["A ciliated cell that is part of a ciliated duct of an airway submucosal gland."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C4085964", "l": "Anti-CD3 OKT3/Anti-EGFR Bispecific Antibody Armed Activated T Lymphocytes", "d": []}, {"i": "NCIT:C124232", "l": "Anti-CD3 OKT3/Anti-EGFR Bispecific Antibody Armed Activated T Lymphocytes", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5555808", "l": "Autologous Anti-CD19 CAR-IL-18-expressing T-lymphocytes", "d": []}, {"i": "NCIT:C179603", "l": "Autologous Anti-CD19 CAR-IL-18-expressing T-lymphocytes", "d": ["A preparation of autologous T-lymphocytes engineered to express a chimeric antigen receptor (CAR) specific for the tumor-associated antigen (TAA) cluster of differentiation 19 (CD19), and expressing the pro-inflammatory cytokine interleukin 18 (IL-18), with potential antineoplastic activity. Upon intravenous administration, autologous anti-CD19 CAR-IL-18-expressing T-lymphocytes target, bind to, and induce selective toxicity in CD19-expressing tumor cells. IL-18 promotes T-cell persistence and potentiates the immune response against tumor cells. CD19 is a B-cell-specific cell surface antigen overexpressed in B-cell lineage tumors. Incorporation of costimulatory signaling domains increases human T-cell function, expansion, and survival."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0229541", "l": "Pituitary chromophobe cell", "d": []}, {"i": "SNOMEDCT:27186004", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157342", "l": "CD19 blasts | Blood | Cell markers", "d": []}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "UMLS:C1513729", "l": "Mucus-Secreting Cell", "d": []}, {"i": "NCIT:C13142", "l": "Mucus-Secreting Cell", "d": ["It is the epithelium cell that produces mucin gel adherent to the mucosal surface. Mucus-secreting cells are widely distributed through the body. (NCI)"]}]}
{"type": "biolink:Cell", "ic": "89.347505587204751", "identifiers": [{"i": "CL:2000030", "l": "hypothalamus cell", "d": ["Any native cell that is part of a hypothalamus."]}]}
{"type": "biolink:Cell", "ic": "90.82444074280258", "identifiers": [{"i": "CL:1001502", "l": "mitral cell", "d": ["The large glutaminergic nerve cells whose dendrites synapse with axons of the olfactory receptor neurons in the glomerular layer of the olfactory bulb, and whose axons pass centrally in the olfactory tract to the olfactory cortex."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C3640939", "l": "tisagenlecleucel", "d": []}, {"i": "MESH:C000626284", "l": "tisagenlecleucel", "d": []}, {"i": "SNOMEDCT:764085003", "d": []}, {"i": "SNOMEDCT:764086002", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5553343", "l": "allogeneic cultured keratinocytes and dermal fibroblasts in murine collagen-dsat", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0000496", "l": "green sensitive photoreceptor cell", "d": ["A photoreceptor cell that is sensitive to green light."]}]}
{"type": "biolink:Cell", "ic": "86.236661114203869", "identifiers": [{"i": "UMLS:C1879717", "l": "Apocrine Carcinoma Cell", "d": []}, {"i": "NCIT:C36908", "l": "Apocrine Carcinoma Cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157460", "l": "CD3+CD8+CD27-CD45RO+CD62L- cells | Blood | Cell markers", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4321645", "l": "Set of embryonic stem cells", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5777106", "l": "LuLym-T", "d": []}]}
{"type": "biolink:Cell", "ic": "86.236661114203869", "identifiers": [{"i": "CL:0000506", "l": "enkephalin secreting cell", "d": ["An endorphine cell that secretes enkephalin."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0333827", "l": "Monocytoid cell", "d": []}, {"i": "SNOMEDCT:35907002", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2717771", "l": "Generative Cells, Plant", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157402", "l": "CD23 cells | Blood | Cell markers", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157302", "l": "CD135 blasts | XXX | Cell markers", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0010016", "l": "collar cell", "d": ["A cell with a flagellum surrounded by a collar of microvilli. The motion of the flagellum draws water past the microvilli, serving either a feeding or sensory function. Collar cells are found in multiple animals, including sponges, echinoderms, and cnidarians. They are also found outside animals in the choanoflagellates. Although collar cells are superficially similar, their cytoskeletal structure and functional biology are different in different groups of organisms."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1689938", "l": "Erythrocyte component of blood", "d": []}, {"i": "SNOMEDCT:418525009", "d": []}]}
{"type": "biolink:Cell", "ic": "86.236661114203869", "identifiers": [{"i": "CL:0000635", "l": "Deiter's cell", "d": ["The outer phalangeal cells of the organ of Corti. This cell holds the base of the hair cell in a cup-shaped depression."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:4023159", "l": "double bouquet cell", "d": ["An interneuron that has double bouquet morphology."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5666817", "l": "Allogeneic Virus-specific T-lymphocytes R-MVST", "d": []}, {"i": "NCIT:C186371", "l": "Allogeneic Virus-specific T-lymphocytes R-MVST", "d": ["A preparation of allogeneic T-lymphocytes generated from partially human leukocyte antigen (HLA)-matched healthy donors or from the original allogeneic hematopoietic stem cell transplantation (HSCT) donor, ex-vivo expanded, and specifically reactive to viruses that may include adenovirus (AdV), cytomegalovirus (CMV), Epstein-Barr virus (EBV) and human polyomavirus type I (BKV), with potential antiviral activity. Upon administration, the allogeneic virus-specific T-lymphocytes R-MVST may kill AdV, CMV, EBV and/or BKV-infected cells, and may prevent or reduce the severity of viral infections by these pathogens."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4239859", "l": "Vascular smooth muscle cell of arch of aorta", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1275629", "l": "Keratocyte", "d": []}, {"i": "SNOMEDCT:397052000", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:4030039", "l": "von Economo neuron", "d": ["An extratelencephalic-projecting glutamatergic cortical neuron that is morphologically-defined with a large, spindle-shaped cell body, thick bipolar dendrites with limited branching and a moderate density of spines, and often an axon initial segment that emanates from the side of the cell body. This cell type is associated with markers POU3F, BMP3 and ITGA4."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0003037", "l": "M7-ON retinal ganglion cell", "d": ["An M7 retinal ganglion cells with synaptic terminals in S4 and is depolarized by illumination of its receptive field center."]}]}
{"type": "biolink:Cell", "ic": "86.236661114203869", "identifiers": [{"i": "UMLS:C1514173", "l": "Pleomorphic Lipoblast", "d": []}, {"i": "NCIT:C36974", "l": "Pleomorphic Lipoblast", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002314", "l": "external supporting cell of vestibular epithelium", "d": ["An auditory epithelial support cell located in the vestibular epithelium that has many hallmarks of glial cells. This cell type express glial markers such as vimentin, S100, glutamate-aspartate transporter, low affinity neurotrophin receptor p75, glial fibrillary acidic protein, and proteolipid protein."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1979665", "l": "Cells.CD19+CD43+", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C4744619", "l": "Autologous Anti-CD38 A2 CAR2-expressing T-cells", "d": []}, {"i": "NCIT:C156170", "l": "Autologous Anti-CD38 A2 CAR2-expressing T-cells", "d": ["A preparation of genetically modified autologous T-cells expressing a chimeric antigen receptor recognizing the tumor-associated antigen (TAA) cluster of differentiation 38 (CD38), with potential immunostimulating and antineoplastic activities. Upon intravenous administration, autologous anti-CD38 A2 CAR2-expressing T-cells are directed to and induce selective toxicity in CD38-expressing tumor cells. CD38, a type II transmembrane glycoprotein, is present on various immune cells and hematologic malignancies, and its expression has been correlated with poor prognosis."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0000940", "l": "mucosal invariant T cell", "d": ["An alpha-beta T cell that is found in the lamina propria of mucosal tissues and is restricted by the MR-1 molecule."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5216271", "l": "Monocytes.immature|NCnc|Pt|Bld", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2334588", "l": "Pyramidal cell of cerebral cortex", "d": []}]}
{"type": "biolink:Cell", "ic": "79.849015605436421", "identifiers": [{"i": "CL:1000692", "l": "kidney interstitial fibroblast", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:2000057", "l": "femural osteoblast", "d": ["Any osteoblast that is part of a femur."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C2984029", "l": "Autologous IL-21-Modulated CD8+ MART1-Specific T Cells", "d": []}, {"i": "NCIT:C91088", "l": "Autologous IL-21-Modulated CD8+ MART1-Specific T Cells", "d": ["A preparation of interleukin 21 (IL-21) stimulated, CD8+ T-lymphocytes sensitized to MART-1 (melanoma antigen recognized by T-cells) antigen with potential immunostimulating and antineoplastic activities. CD8+ T-lymphocytes are exposed ex vivo to autologous dendritic cells (DCs) pulsed with MART-1 antigen peptide and grown in the presence of IL-21. These tumor-reactive T-cells may stimulate a host immune response against tumor cells expressing the MART-1 antigen, resulting in tumor cell lysis. MART-1 is expressed by certain types of melanoma cells. IL-21, a cytokine involved in the regulation of cellular immune responses, may play a key role during priming of antigen-specific CD8+ T cells and may enhance proliferation of the CTLs."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5540530", "l": "keratinocytes, fibroblasts, collagen-dsat", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1179892", "l": "Transitional myocyte", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5161797", "l": "Cytoplasmic CD179a blasts | XXX | Cell markers", "d": []}]}
{"type": "biolink:Cell", "ic": "90.82444074280258", "identifiers": [{"i": "CL:0002225", "l": "secondary lens fiber", "d": ["A lens fiber cell that develops from primary lens fiber; located towards the center of lens; cell organelles are normally degraded or in the process of being degraded."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5170958", "l": "Leukocytes other | Synovial fluid | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5417706", "l": "Allogeneic Glial Progenitor Cells", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002541", "l": "chorionic membrane mesenchymal stem cell", "d": ["A mesenchymal stem cell of the chorionic membrane."]}]}
{"type": "biolink:Cell", "ic": "74.953330836288131", "identifiers": [{"i": "CL:0000765", "l": "erythroblast", "d": ["A nucleated precursor of an erythrocyte that lacks hematopoietic lineage markers."]}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "CL:0002635", "l": "nonkeratinized epithelial cell of anal column", "d": ["A nonkeratinized epithelial cell of the anal canal."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5401608", "l": "Multipotent Adult Progenitor Cells (MAPCs)", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2325384", "l": "Epithelial cell of urethra", "d": []}]}
{"type": "biolink:Cell", "ic": "89.347505587204751", "identifiers": [{"i": "UMLS:C1708913", "l": "Malignant Spindle-Shaped Osteoblast", "d": []}, {"i": "NCIT:C53957", "l": "Malignant Spindle-Shaped Osteoblast", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5421028", "l": "Tebrocabtagene Autoleucel", "d": []}, {"i": "NCIT:C174931", "l": "Tebrocabtagene Autoleucel", "d": []}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "UMLS:C1519459", "l": "Spindle-Shaped Meningothelial Cell", "d": []}, {"i": "NCIT:C37156", "l": "Spindle-Shaped Meningothelial Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5418966", "l": "Anti-CD37-CAR-expressing T-lymphocytes", "d": []}, {"i": "NCIT:C171034", "l": "Anti-CD37-CAR-expressing T-lymphocytes", "d": ["A preparation of T-lymphocytes that have been genetically modified to express a chimeric antigen receptor (CAR) targeting the tumor-associated antigen (TAA) CD37 (cluster of differentiation 37), with potential immunostimulating and antineoplastic activities. Upon administration, anti-CD37-CAR T-cells specifically recognize and kill CD37-expressing tumor cells. CD37, a member of the tetraspanin superfamily of cell surface antigens, is expressed in B-cell non-Hodgkin lymphomas (NHL), in chronic lymphocytic leukemia (CLL), and in some cases of cutaneous and peripheral T-cell lymphomas. It plays a key role in tumor cell proliferation."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2327156", "l": "Enterocyte of epithelium proper of duodenum", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1440255", "l": "Cells.CD138", "d": []}]}
{"type": "biolink:Cell", "ic": "92.728541327098611", "identifiers": [{"i": "UMLS:C1709165", "l": "Neoplastic C-Cell", "d": []}, {"i": "NCIT:C47802", "l": "Neoplastic C-Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "85.457082654197222", "identifiers": [{"i": "CL:0000096", "l": "mature neutrophil", "d": ["A fully differentiated neutrophil, a granular leukocyte having a nucleus with three to five lobes connected by slender threads, and cytoplasm containing fine inconspicuous granules and stainable by neutral dyes. They are produced in bone marrow at a rate of 5e10-10e10/day and have a half-life of 6-8 hours. Neutrophils are CD15-positive, CD16-positive, CD32-positive, CD43-positive, CD181-positive, and CD182-positive."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4324118", "l": "CD28+ T lymphocyte", "d": []}]}
{"type": "biolink:Cell", "ic": "87.120474278337809", "identifiers": [{"i": "UMLS:C1514051", "l": "Neoplastic Non-Cutaneous Basaloid Cell", "d": []}, {"i": "NCIT:C36782", "l": "Neoplastic Non-Cutaneous Basaloid Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "77.488267285704651", "identifiers": [{"i": "CL:0000135", "l": "fibrocyte", "d": ["An inactive fibroblast; cytoplasm is sparse, endoplasmic reticulum is scanty with flattened nucleus. Term used by some histologists; when fibroblasts become relatively inactive in fiber formation. However, this cell has the potential for fibrogenesis in quiescent connective tissue of the adult, as well as during development, other histologists prefer to use the term fibroblast in all circumstances. These cells represent ~0.5% of peripheral blood leukocytes."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002618", "l": "endothelial cell of umbilical vein", "d": ["An endothelial cell of the umbilical vein."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0000309", "l": "copper accumulating cell", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5706444", "l": "Allogeneic Anti-CD19 CAR-NK Cells QN-019a", "d": []}, {"i": "NCIT:C188046", "l": "Allogeneic Anti-CD19 CAR-NK Cells QN-019a", "d": ["A preparation of allogeneic natural killer (NK) cells engineered to express a chimeric antigen receptor (CAR) specific for the tumor-associated antigen (TAA) cluster of differentiation 19 (CD19), with potential immunomodulating and antineoplastic activities. Upon administration, the allogeneic anti-CD19 CAR-NK cells QN-019a recognize, bind to and induce selective cytotoxicity in CD19-expressing tumor cells. CD19 is a B-cell specific cell surface antigen overexpressed in B-cell lineage malignancies."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5761823", "l": "Attenuated autologous cancer cells and granulocyte macrophage colony stimulating factor in combination with activated autologous blood derived T-cells", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1517818", "l": "Mouse Pre-T-Lymphocyte", "d": []}, {"i": "NCIT:C22580", "l": "Mouse Pre-T-Lymphocyte", "d": []}]}
{"type": "biolink:Cell", "ic": "86.236661114203869", "identifiers": [{"i": "CL:0002129", "l": "regular atrial cardiac myocyte", "d": ["Regular cardiac myocyte of a cardiac atrium."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C2981181", "l": "Autologous PBTL CD19CAR-28 zeta", "d": []}, {"i": "NCIT:C78823", "l": "Autologous PBTL CD19CAR-28 zeta", "d": ["A preparation of autologous peripheral blood T-lymphocytes (PBTL) that have been genetically modified to express the chimeric antigen receptor (CAR) anti-CD19/CD3 zeta chain fusion protein coupled to the intracellular signal domain of CD28 antigen, with potential immunostimulating and antineoplastic activities. Upon administration, autologous PBTL CD19CAR-28 zeta may stimulate host cytotoxic T lymphocyte (CTL) and antibody responses against CD19-expressing tumor cells, resulting in tumor cell lysis. CD19 antigen is a B-cell specific cell surface antigen expressed in all B-cell lineage malignancies. CD3 zeta is one of several membrane-bound polypeptides found in the T-cell receptor (TCR)/CD3 complex and regulates the assembly of complete TCR complexes and their expression on the cell surface. CD28 is essential for CD4+ T-cell proliferation, interleukin-2 production, and T-helper type-2 (Th2) development."]}]}
{"type": "biolink:Cell", "ic": "88.140761698499901", "identifiers": [{"i": "CL:0000179", "l": "progesterone secreting cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5220576", "l": "Epithelial cells.squamous|Urine/Urine sed", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0085820", "l": "Antibody-Secreting Cells", "d": []}]}
{"type": "biolink:Cell", "ic": "92.728541327098611", "identifiers": [{"i": "CL:1000236", "l": "posterior lateral line nerve glial cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157435", "l": "CD3+CD4+ (T4 helper) cells | Blood | Cell markers", "d": []}]}
{"type": "biolink:Cell", "ic": "66.007347202863528", "identifiers": [{"i": "UMLS:C1514003", "l": "Neoplastic Large Germ Cell", "d": []}, {"i": "NCIT:C36904", "l": "Neoplastic Large Germ Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5666969", "l": "CBL-B Inhibitor-treated Autologous Tumor-infiltrating Lymphocytes DeTIL-0255", "d": []}, {"i": "NCIT:C185289", "l": "CBL-B Inhibitor-treated Autologous Tumor-infiltrating Lymphocytes DeTIL-0255", "d": ["A preparation of autologous tumor-infiltrating lymphocytes (TILs) derived from a patient's tumor that have been treated ex vivo during cell expansion with NX-0255, an inhibitor of Casitas B-lineage lymphoma proto-oncogene-b (CBL-B), with potential immunomodulating and antineoplastic activities. Upon administration, the CBL-B inhibitor-treated autologous TILs DeTIL-0255 specifically recognize and kill the patient's tumor cells. NX-0255 enhances TIL expansion and the tumor-killing ability of the TILs when returned to the patient."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5401603", "l": "CYNK-001", "d": []}, {"i": "NCIT:C173877", "l": "Taniraleucel", "d": ["A population of cryopreserved, off-the-shelf (OTS) allogeneic natural killer (NK) cells derived from human placental hematopoietic stem cells (HSCs) and expressing the CD56 surface antigen and exhibiting a lack of CD3, with potential immunomodulating, antineoplastic and antiviral activities. Upon infusion of taniraleucel, these cells are able to recognize tumor cells as well as virally-infected cells, secrete perforins, granzymes and cytokines, and induce apoptosis in tumor and virally-infected cells."]}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "CL:0000346", "l": "hair follicle dermal papilla cell", "d": ["A specialized mesenchymal cell that resides in the dermal papilla located at the bottom of hair follicles. This cell plays a pivotal roles in hair formation, growth, and cycling."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5420310", "l": "Autologous Anti-CD19 CAR T-cells 19(T2)28z1xx", "d": []}, {"i": "NCIT:C173622", "l": "Autologous Anti-CD19 CAR T-cells 19(T2)28z1xx", "d": ["A preparation of autologous T-lymphocytes that have been genetically modified to express a chimeric antigen receptor (CAR) targeting the tumor-associated antigen (TAA) CD19, and linked to the co-stimulatory intracellular signaling domains of CD28 and the zeta chain of the TCR/CD3 complex (CD3-zeta) (CD28zeta; CD28z), with potential immunostimulating and antineoplastic activities. Upon administration, the autologous anti-CD19 CAR T-cells 19(T2)28z1xx specifically recognize and bind to CD19-expressing tumor cells, resulting in specific T-cell-mediated tumor cell lysis. CD19 antigen is a B-cell specific cell surface antigen, which is expressed in all B-cell lineage malignancies and normal B-cells. CD28 and CD3zeta provide co-stimulatory activity and may enhance the cytotoxic effect and anti-tumor activity of the CAR T-cells. The 19(T2)28z1xx CAR T-cells include a 1928zeta mutant, 1xx, which contains one instead of all three immunoreceptor tyrosine-based activation motifs (iTAMs). This may help prevent counterproductive T-cell differentiation and exhaustion."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5174614", "l": "Neutrophils | Body fluid | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "ic": "79.849015605436421", "identifiers": [{"i": "UMLS:C0002449", "l": "Ameloblasts", "d": []}, {"i": "NCIT:C12579", "l": "Ameloblast", "d": ["A columnar epithelial cell located in the inner layer of the enamel organ of a developing tooth that plays a role in calcium transport and the synthesis and resorption of enamel matrix proteins."]}, {"i": "MESH:D000565", "l": "Ameloblasts", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4518176", "l": "Population of all promyelocytes in portion of fluid", "d": []}, {"i": "SNOMEDCT:726509004", "d": []}]}
{"type": "biolink:Cell", "ic": "48.638099452297539", "identifiers": [{"i": "CL:0011026", "l": "progenitor cell", "d": ["A precursor cell that has a tendency to differentiate into a specific type of cell. They are descendants of stem cells, only they are more constrained in their differentiation potential or capacity for self-renewal, and are often more limited in both senses."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1182625", "l": "Epithelial cell of buccal part of viscerocranial mucosa", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1511439", "l": "CH01", "d": []}, {"i": "NCIT:C20285", "l": "CH01", "d": ["Provider: Pochon CHA University, Seoul, Korea. No information from provider. This cell line meets the criteria for the use of human embryonic stem cells by federally funded researchers."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5382745", "l": "CD107a+b expressing Cytomegalovirus-specific CD8 cells | Blood | Cell markers", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2349679", "l": "Atypical cervical glandular cells NOS", "d": []}]}
{"type": "biolink:Cell", "ic": "92.728541327098611", "identifiers": [{"i": "CL:0000925", "l": "activated CD4-positive type I NK T cell", "d": ["A type I NK T cell that has been recently activated, secretes interferon-gamma and IL-4, and has the phenotype CD4-positive, CD69-positive, and downregulated NK markers."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5557247", "l": "Anti-CAIX CAR T Cells", "d": []}, {"i": "NCIT:C181752", "l": "Anti-CAIX CAR T Cells", "d": ["A preparation of T-lymphocytes that have been genetically modified to express a chimeric antigen receptor (CAR) targeting the tumor-associated antigen (TAA) carbonic anhydrase IX (CAIX; carbonic anhydrase 9; CA9; G250), with potential immunostimulating and antineoplastic activities. Upon administration, anti-CAIX CAR T-cells target and bind to CAIX-expressing tumor cells, thereby inducing selective toxicity in CAIX-expressing tumor cells. CAIX is a member of the carbonic anhydrase family that is found in a majority of renal cell carcinomas while absent in most normal tissues."]}]}
{"type": "biolink:Cell", "ic": "76.281523396999802", "identifiers": [{"i": "UMLS:C1513981", "l": "Neoplastic Granulosa Cell", "d": []}, {"i": "NCIT:C36894", "l": "Neoplastic Granulosa Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "55.940678693798461", "identifiers": [{"i": "CL:0000498", "l": "inhibitory interneuron", "d": ["An interneuron (also called relay neuron, association neuron or local circuit neuron) is a multipolar neuron which connects afferent neurons and efferent neurons in neural pathways. Like motor neurons, interneuron cell bodies are always located in the central nervous system (CNS)."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5166079", "l": "Granulocytes | Blood | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1440396", "l": "Cells.SmIg-CD79", "d": []}]}
{"type": "biolink:Cell", "ic": "85.457082654197222", "identifiers": [{"i": "CL:0001658", "l": "visual pigment cell (sensu Nematoda and Protostomia)", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0000479", "l": "vasopressin stimulating hormone secreting cell", "d": ["A peptide hormone secreting cell that secretes vasopressin stimulating hormone"]}]}
{"type": "biolink:Cell", "ic": "55.949191578468927", "identifiers": [{"i": "CL:0011005", "l": "GABAergic interneuron", "d": ["An interneuron that uses GABA as a vesicular neurotransmitter.  These interneurons are inhibitory"]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0684116", "l": "megaloblast of Sabin", "d": []}]}
{"type": "biolink:Cell", "ic": "64.998193119084064", "identifiers": [{"i": "CL:0000673", "l": "Kenyon cell", "d": ["An intrinsic neuron of the mushroom body of arthropods and annelids. They have tightly packed, cytoplasm-poor cell bodies."]}]}
{"type": "biolink:Cell", "ic": "80.17194633000733", "identifiers": [{"i": "UMLS:C1517440", "l": "Ganglion-Like Cell", "d": []}, {"i": "NCIT:C36981", "l": "Ganglion-Like Cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5216205", "l": "Eosinophils|NCnc|Pt|Synv fld", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0000927", "l": "CD4-positive type I NK T cell secreting interleukin-4", "d": ["A mature NK T cell that predominantly secretes type 2 cytokines such as interleukin-4 and interleukin-13 and enhances type 2 immune responses."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C4086008", "l": "Autologous Interferon-producing Killer Dendritic Cells", "d": []}, {"i": "NCIT:C125667", "l": "Autologous Interferon-producing Killer Dendritic Cells", "d": ["A preparation of autologous dendritic cells (DC) with a molecular expression profile similar to both natural killer (NK) cells and DCs, with potential antineoplastic activity. Autologous interferon-producing killer dendritic cells (IKDCs) are characterized by double-negative expression of CD3 and CD19; these cells also express low levels of CD11 and are positive for B220. They are distinguished from plasmacytoid DCs (pDCs) by the absence of lymphocyte antigen 6C (Ly6C, Gr-1) expression. IKDCs produce interferon gamma (IFN-gamma) and interleukin (IL) -12, and are able to kill typical NK target cells using NK receptors while retaining DC-like antigen-presenting activity. Upon administration of the autologous IKDCs, these cells secrete high levels of IFN-gamma and, when in contact with tumor cells, mediate TNF-related apoptosis-inducing ligand (TRAIL)-dependent direct lysis of tumor cells. The resulting apoptotic tumor antigens may be presented by the IKDCs, thus activating the immune system to exert a cytotoxic T-lymphocyte (CTL) response to further eliminate tumor cells."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0009065", "l": "tuft cell of anorectum", "d": ["An intestinal tuft cell that is located in the anorectum."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157263", "l": "CD117 cells | Blood | Cell markers", "d": []}]}
{"type": "biolink:Cell", "ic": "89.347505587204751", "identifiers": [{"i": "UMLS:C1709201", "l": "Neoplastic Somatotroph Cell with Abundant Secretory Granules", "d": []}, {"i": "NCIT:C45939", "l": "Neoplastic Somatotroph Cell with Abundant Secretory Granules", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0000744", "l": "columnar chondrocyte", "d": ["A columnar chondrocyte that differentiates in the late embryonic growth plate of bone. Columnar chondrocytes vigorously proliferate and form columns in the growth plate."]}]}
{"type": "biolink:Cell", "ic": "90.82444074280258", "identifiers": [{"i": "UMLS:C0004827", "l": "Basophils", "d": []}, {"i": "NCIT:C12531", "l": "Basophil", "d": []}, {"i": "MESH:D001491", "l": "Basophils", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002325", "l": "mammary alveolar cell", "d": ["The milk-producing cell of the alveolar unit that emerges during pregnancy."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1510963", "l": "Atypical Reparative Cell", "d": []}, {"i": "NCIT:C36785", "l": "Atypical Reparative Cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5174622", "l": "Neutrophils | Pleural fluid | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5667674", "l": "Autologous MGMTP140K Lentiviral Vector-transduced HSCs", "d": []}, {"i": "NCIT:C182624", "l": "Autologous MGMTP140K Lentiviral Vector-transduced HSCs", "d": ["A preparation of autologous CD34+ hematopoietic stem cells (HSCs) transduced with a lentiviral-based proviral vector encoding for MGMTP140K, a mutant version of the human DNA repair protein O6-alkylguanine-DNA methyltransferase (MGMT), with potential protective activity against myelosuppression. MGMTP140K is resistant to the MGMT inhibitor O6-benzylguanine (O6BG; BG). Upon administration of the autologous MGMTP140K lentiviral vector-transduced HSCs back into the patient, the HSCs expressing the BG-resistant mutant MGMT protein could, when used in combination with BG, protect the hematopoietic system against the hematopoietic toxicity of BG by enabling normal methyltransferase activity. This protects hematopoiesis and allows for temozolomide (TMZ) and BG chemotherapy without myelosuppression. MGMT repairs TMZ-induced DNA methylation. The MGMT inhibitor BG depletes MGMT and thereby maximizes TMZ-mediated anti-tumor response. The depletion of MGMT in hematopoietic cells leads to unacceptable bone marrow toxicity."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4706843", "l": "Indium (111-In) labeled granulocyte", "d": []}, {"i": "SNOMEDCT:763410001", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5454449", "l": "Nucleated erythrocytes | Blood cord | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4322675", "l": "CD8+CD38+ T lymphocyte", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0009098", "l": "fetal and neonatal skeletal muscle fiber", "d": ["A skeletal muscle fiber found at the fetal and neonatal stages. In mammalian fetuses and neonates, skeletal muscle expresses myosin heavy chain-neonatal (MyHC-neo, encoded by the MYH8 gene). This expression disappears shortly after birth and is replaced by expression of adult heavy chain myosins."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2336790", "l": "Macroglial cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0222619", "l": "Structure of granular polyhedral cells of breast", "d": []}, {"i": "SNOMEDCT:15192008", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1182654", "l": "Corneal endothelial cell", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5555820", "l": "T-regulatory Cell-enriched Donor Cells", "d": []}, {"i": "NCIT:C179619", "l": "T-regulatory Cell-enriched Donor Cells", "d": ["A preparation of donor-derived T-cells that have been enriched with donor T-regulatory (Treg) cells, with potential immunomodulating activity. Upon administration of the Treg cell-enriched donor cells prior to hematopoietic stem cell transplantation (HSCT), the donor cells may induce tolerance to HSCT and may reduce risk of relapse and graft-versus-host-disease (GVHD) in hematologic malignancies."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5216204", "l": "Eosinophils|NCnc|Pt|Plr fld", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1441342", "l": "100 leukocytes", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157432", "l": "CD3+CD25+ cells | Tissue and Smears | Cell markers", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5216245", "l": "Lymphocytes.immunoblastic|NCnc|Pt|Bld", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0882818", "l": "Cell positive for CD20 antigen", "d": []}, {"i": "SNOMEDCT:116754005", "d": []}]}
{"type": "biolink:Cell", "ic": "90.82444074280258", "identifiers": [{"i": "UMLS:C1883692", "l": "Small to Medium Size Adenocarcinoma Cell with Oval Nucleus", "d": []}, {"i": "NCIT:C62176", "l": "Small to Medium Size Adenocarcinoma Cell with Oval Nucleus", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0682521", "l": "primate cell line", "d": []}]}
{"type": "biolink:Cell", "ic": "85.457082654197222", "identifiers": [{"i": "CL:0000116", "l": "pioneer neuron", "d": ["Pioneer neurons establish a pathway in the developing central nervous system and then undergo programmed cell death once the adult axons, which follow them, have made connections with the target site. Thus, they are a transient cell type involved in axon guidance."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5667017", "l": "Anti-Claudin18.2 CAR T Cells IBI345", "d": []}, {"i": "NCIT:C185607", "l": "Anti-Claudin18.2 CAR T Cells IBI345", "d": ["A preparation of T-lymphocytes engineered to express a chimeric antigen receptor (CAR) specific for the tumor-associated antigen (TAA) Claudin18.2 (CLDN18.2; A2 isoform of claudin-18), with potential immunostimulating and antineoplastic activities. Upon administration, anti-CLDN18.2 CAR T cells IBI345 specifically recognize and induce selective toxicity in CLDN18.2-expressing tumor cells. CLDN18.2, a tight junction protein, is expressed on a variety of tumor cells, but its expression in healthy tissues is strictly confined to short-lived differentiated epithelial cells of the gastric mucosa."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0524458", "l": "Upper motor neuron", "d": []}, {"i": "SNOMEDCT:91769000", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2328288", "l": "Set of Ch4 cholinergic cells", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5180577", "l": "Segmented neutrophils | Peritoneal fluid | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1515147", "l": "TE04 Cell Line", "d": []}, {"i": "NCIT:C20299", "l": "TE04", "d": ["Provider: Technion University, Haifa, Israel. No information from provider. This cell line meets the criteria for the use of human embryonic stem cells by federally funded researchers."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5163717", "l": "Erythrocytes | Fetus | Blood | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157241", "l": "CD10+CD25+ cells | Blood | Cell markers", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002168", "l": "border cell of cochlea", "d": ["A border cell is a slender columnar cell on the medial portion of the basilar membrane."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C3827013", "l": "AdGMCAIX-transduced Autologous Dendritic Cells", "d": []}, {"i": "NCIT:C105809", "l": "AdGMCAIX-transduced Autologous Dendritic Cells", "d": ["Autologous dendritic cells (DCs) transduced with a recombinant, replication-defective adenoviral vector expressing the fusion gene granulocyte-macrophage colony-stimulating factor (GM-CSF) and carbonic anhydrase IX (CA-IX or CA9) (GMCA-9), with potential immunomodulating activity. The autologous DCs are transduced ex vivo and express the GMCA-9 fusion protein on the cell surface. Upon intradermal administration of the AdGMCAIX-transduced autologous DCs back into the patient, the DCs activate the immune system to both mount a cytotoxic T lymphocyte-mediated response against tumor cells positive for the CA9 antigen, and generate memory T cells. This may result in decreased tumor growth. CA9, also known as G250, is a renal cell carcinoma (RCC)-associated antigen and a member of the carbonic anhydrase family that contains a human leukocyte antigen (HLA)-A2.1-restricted epitope; it is found in a majority of renal cell carcinomas while absent in most normal tissues. The cytokine GM-CSF enhances the immunogenicity of CA9-based DC vaccines."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5549474", "l": "Spermatozoa | Urine | Fertility testing", "d": []}]}
{"type": "biolink:Cell", "ic": "92.728541327098611", "identifiers": [{"i": "CL:0002384", "l": "uninucleate macroconidium", "d": ["A macroconidium that has only one nucleus."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0019022", "l": "endothelial cell of pericentral hepatic sinusoid", "d": ["An endothelial cell found in the centrilobular region hepatic sinusoid, near the central vein. The fenestrae of these cells are smaller but more numerous compared with those of endothelial cells near the periportal region of the hepatic sinusoid."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1440423", "l": "Terminal deoxyribonucleotidyl transferase cells", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5448063", "l": "Autologous Anti-CD22 CAR-expressing T-cells SCRI-CAR22v2", "d": []}, {"i": "NCIT:C176568", "l": "Autologous Anti-CD22 CAR-expressing T-cells SCRI-CAR22v2", "d": ["A preparation of autologous human T-lymphocytes that are genetically engineered to express a chimeric antigen receptor (CAR) targeting the tumor-associated antigen (TAA) CD22, with potential immunostimulating and antineoplastic activities. Upon administration, the autologous anti-CD22 CAR-expressing T-cells SCRI-CAR22v2 express anti-CD22-CAR on their cell surfaces and bind to the CD22 antigen on tumor cell surfaces leading to lysis of CD22-expressing B-cells. CD22, a B-lineage-restricted, transmembrane phosphoglycoprotein, is expressed on malignant B-cells."]}]}
{"type": "biolink:Cell", "ic": "90.82444074280258", "identifiers": [{"i": "UMLS:C0079722", "l": "Lymphocytes, Tumor-Infiltrating", "d": []}, {"i": "NCIT:C12546", "l": "Tumor Infiltrating Lymphocyte", "d": ["Lymphocytes that show specificity for autologous tumor cells and can infiltrate a tumor."]}, {"i": "MESH:D016246", "l": "Lymphocytes, Tumor-Infiltrating", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5380998", "l": "Cells.CD8.CMV specific", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157242", "l": "CD10+HLA-DR+ cells | Blood | Cell markers", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0230522", "l": "Mitotic cell in telophase", "d": []}, {"i": "SNOMEDCT:31443005", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5174621", "l": "Neutrophils | Peritoneal fluid | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "ic": "64.330990311268877", "identifiers": [{"i": "UMLS:C0016030", "l": "Fibroblasts", "d": []}, {"i": "NCIT:C12482", "l": "Fibroblast", "d": []}, {"i": "MESH:D005347", "l": "Fibroblasts", "d": []}, {"i": "SNOMEDCT:52547004", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5178309", "l": "Promyelocytes | Fetus | Blood | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C4725001", "l": "MDS Neoantigen-specific Autologous T-lymphocytes", "d": []}, {"i": "NCIT:C148393", "l": "MDS Neoantigen-specific Autologous T-lymphocytes", "d": ["A preparation of autologous T-lymphocytes that are exposed, ex vivo, to multiple, patient-specific myelodysplastic syndrome (MDS) stem cell neoantigens, with potential immunostimulating and antineoplastic activities. Upon infusion of the MDS neoantigen-specific autologous T-lymphocytes, the immunized T-cells specifically target and lyse cells expressing the MDS neoantigens."]}]}
{"type": "biolink:Cell", "ic": "85.457082654197222", "identifiers": [{"i": "CL:0002343", "l": "decidual natural killer cell, human", "d": ["A natural killer cell subset that is found in the decidual of the uterus and is CD56-high, Galectin-1-positive and CD16-negative. This cell type represents the most abundant immune cell type in the decidual during the first trimester of pregnancy."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1522374", "l": "Dendritic Cell - Langerhans Cell (MMHCC)", "d": []}, {"i": "NCIT:C24191", "l": "Mouse Langerhans Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1514161", "l": "Mouse Platelet", "d": []}, {"i": "NCIT:C22568", "l": "Mouse Platelet", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1276853", "l": "Entire parathyroid oxyphil cell", "d": []}, {"i": "SNOMEDCT:177826000", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0000376", "l": "humidity receptor cell", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002558", "l": "fibroblast of villous mesenchyme", "d": ["A fibroblast that is part of villous mesenchyme."]}]}
{"type": "biolink:Cell", "ic": "88.140761698499901", "identifiers": [{"i": "CL:0004115", "l": "retinal ganglion cell B", "d": ["A monostratified retinal ganglion cell with small to medium soma and small to medium dendritic field."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:4023079", "l": "midbrain-derived inhibitory neuron", "d": ["A GABAergic inhibitory neuron that is derived from the midbrain."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:1001608", "l": "foreskin fibroblast", "d": ["Fibroblast from foreskin."]}]}
{"type": "biolink:Cell", "ic": "59.068559899291635", "identifiers": [{"i": "CL:0002419", "l": "mature T cell", "d": ["A T cell that expresses a T cell receptor complex and has completed T cell selection."]}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "UMLS:C1514221", "l": "Poorly Differentiated Adenocarcinoma Cell", "d": []}, {"i": "NCIT:C36798", "l": "Poorly Differentiated Adenocarcinoma Cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1440322", "l": "Cells.CD49b", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:1000329", "l": "tracheal goblet cell", "d": ["A goblet cell that is part of the epithelium of trachea."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:2000093", "l": "bronchus fibroblast of lung", "d": ["Any fibroblast of lung that is part of a bronchus."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5419025", "l": "Autologous Anti-CD123 CAR-T Cells", "d": []}, {"i": "NCIT:C171167", "l": "Autologous Anti-CD123 CAR-T Cells", "d": ["A preparation of autologous T-cells engineered to express a chimeric antigen receptor (CAR) specific for the tumor-associated antigen (TAA) CD123 (interleukin-3 receptor alpha chain or IL3RA), with potential immunostimulating and antineoplastic activities. Upon administration, the autologous anti-CD123 CAR-T cells target and bind to CD123 expressed on the surface of tumor cells. This induces selective toxicity in CD123-expressing tumor cells. CD123, the alpha subunit of the IL-3 receptor, regulates the proliferation, survival and differentiation of hematopoietic cells. It is overexpressed on a variety of cancers, including myeloid leukemia, and the increased expression of CD123 on leukemic stem cells (LSCs) is associated with poor prognosis."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:2000013", "l": "fibroblast of skin of abdomen", "d": ["Any skin fibroblast that is part of a skin of abdomen."]}]}
{"type": "biolink:Cell", "ic": "92.728541327098611", "identifiers": [{"i": "CL:0000931", "l": "activated type II NK T cell", "d": ["A type II NK T cell that has been recently activated, secretes interferon-gamma and interleukin-4, and has the phenotype CD69-positive and downregulated NK markers."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5216262", "l": "Malignant cells|NCnc|Pt|Periton fld", "d": []}]}
{"type": "biolink:Cell", "ic": "92.728541327098611", "identifiers": [{"i": "CL:0002272", "l": "motilin secreting cell", "d": ["A cell that secretes motilin, a gastric hormone that at low pH inhibits gastric motor activity, whereas at high pH has a stimulating effect."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1522171", "l": "Lung - Clara Cell (MMHCC)", "d": []}, {"i": "NCIT:C22603", "l": "Mouse Club Cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0229617", "l": "Medium sized lymphocyte", "d": []}, {"i": "SNOMEDCT:52180000", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5163683", "l": "Erythrocyte clumps | Urine sediment | Urinalysis", "d": []}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "CL:0000314", "l": "milk secreting cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1267922", "l": "Lymphocyte positive for CD42B antigen", "d": []}, {"i": "SNOMEDCT:117366008", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C4726578", "l": "Autologous Anti-Muc1/CD33/CD38/CD56/CD123 Gene-engineered CAR-T Cells", "d": []}, {"i": "NCIT:C151954", "l": "Autologous Anti-Muc1/CD33/CD38/CD56/CD123 Gene-engineered CAR-T Cells", "d": ["A preparation of genetically modified autologous T-cells transduced with lentiviral vectors expressing chimeric antigen receptors (CARs) specific for the tumor-associated antigens (TAAs) mucin 1 (Muc1; MUC1), cluster of differentiation 33 (CD33), CD38, CD56 and CD123 (interleukin-3 receptor alpha chain or IL3RA), with potential immunostimulating and antineoplastic activities. Upon intravenous administration, autologous anti-Muc1/CD33/CD38/CD56/CD123 gene-engineered CAR-T cells are directed to and induce selective toxicity in Muc1/CD33/CD38/CD56/CD123-expressing tumor cells. Muc1/CD33/CD38/CD56/CD123 are present on certain tumor cell types and are minimally expressed on normal, healthy cells. Expression of these TAAs are correlated with poor prognosis. CD28, CD137 and CD27, T-cell surface-associated co-stimulatory molecules included in the CARs, are required for full T-cell activation and enhance both proliferation of T-cells and antitumor activity."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:1000471", "l": "myoepithelial cell of secondary lactiferous duct", "d": ["A myoepithelial cell that is part of the secondary lactiferous duct."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5216202", "l": "Eosinophils|NCnc|Pt|Pericard fld", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5571714", "l": "Transitional cells.superficial|Urine/Urine sed", "d": []}]}
{"type": "biolink:Cell", "ic": "60.443926305975602", "identifiers": [{"i": "CL:0000789", "l": "alpha-beta T cell", "d": ["A T cell that expresses an alpha-beta T cell receptor complex."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5175608", "l": "Other cells | Synovial fluid | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5148824", "l": "Reticulocytes.low fluorescence", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1317197", "l": "Cells.CD4+CD45RO+", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002497", "l": "primary trophoblast giant cell", "d": ["A trophoblast giant cell derived from the mural trophectoderm."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0001043", "l": "activated CD4-positive, alpha-beta T cell, human", "d": ["A recently activated CD4-positive, alpha-beta T cell with the phenotype HLA-DRA-positive, CD38-positive, CD69-positive, CD62L-negative, CD127-negative, and CD25-positive."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:4023171", "l": "trigeminal motor neuron", "d": ["A trigeminal neuron that is responsible for motor functions such as biting and chewing."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:4030037", "l": "late spermatid", "d": ["A spermatid in a late stage of maturation that has an elongated morphology and is transcriptionally inert when the acrosome is fully developed."]}]}
{"type": "biolink:Cell", "ic": "73.124874125835319", "identifiers": [{"i": "CL:0000518", "l": "phagocyte (sensu Vertebrata)", "d": ["A phagocyte in vertebrates that is able to phagocytosis."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0229663", "l": "Marrow fibroblast", "d": []}, {"i": "SNOMEDCT:24151005", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C4724406", "l": "Anti-minor Histocompatibility Complex Donor T-Lymphocytes", "d": []}, {"i": "NCIT:C148500", "l": "Anti-minor Histocompatibility Complex Donor T-Lymphocytes", "d": ["A preparation of allogeneic, donor-derived T-lymphocytes that are specific for a unique set of minor histocompatibility complex antigens (MiHA) exclusively found on the surface of malignant cells, with potential immunomodulating and antineoplastic activities. T-lymphocytes are derived from an allogeneic hematopoietic cell transplant (AHCT) donor. Ex vivo, these T-cells are exposed to and primed against a select set of host-specific hematopoietic tissue-restricted MiHAs that are expressed on leukemic cells. Then the cells are subsequently expanded. After AHCT and infusion of the anti-MiHA T-lymphocytes, these cells target and bind to MiHA antigens expressed on the host's leukemia cells, thereby killing these cancer cells. MiHA are small, cell-surface peptides that are associated with graft-versus-host disease (GvHD). The selected set of MiHAs is expressed mainly, or only, by hematopoietic cells, and overexpressed on leukemic cells."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1267940", "l": "Lymphocyte positive for CD49E antigen", "d": []}, {"i": "SNOMEDCT:117383004", "d": []}]}
{"type": "biolink:Cell", "ic": "92.728541327098611", "identifiers": [{"i": "UMLS:C1882058", "l": "Neoplastic Sertoli Cell with Clear Cytoplasm", "d": []}, {"i": "NCIT:C61418", "l": "Neoplastic Sertoli Cell with Clear Cytoplasm", "d": []}]}
{"type": "biolink:Cell", "ic": "80.17194633000733", "identifiers": [{"i": "UMLS:C0005821", "l": "Blood Platelets", "d": []}, {"i": "NCIT:C12520", "l": "Platelet", "d": ["An irregular, disc-shaped element in the blood that assists in blood clotting. Platelets are not blood cells, they are fragments of large bone marrow cells called megakaryocytes."]}, {"i": "MESH:D001792", "l": "Blood Platelets", "d": []}, {"i": "SNOMEDCT:16378004", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5555575", "l": "Autologous MAGE-C2-specific HLA-A2-restricted TCR T-lymphocytes", "d": []}, {"i": "NCIT:C179275", "l": "Autologous MAGE-C2-specific HLA-A2-restricted TCR T-lymphocytes", "d": ["A preparation of autologous T-lymphocytes genetically modified to express a T-cell receptor (TCR) specific for human leukocyte antigen (HLA)-A2-restricted, melanoma-associated antigen C2 (MAGE-C2; MC2), ALK epitope, with potential antineoplastic activity. Peripheral blood mononuclear cells (PBMCs) are isolated from a patient, transduced with an anti-MAGE-C2-HLA-A2 restricted TCR, expanded ex vivo, and reintroduced into the HLA-A2-positive patient. Upon reintroduction, the autologous MAGE-C2-specific HLA-A2-restricted TCR T-lymphocytes bind to tumor cells expressing the MAGE-C2 antigen, which may induce cell death in and halt the growth of MAGE-C2-expressing cancer cells. MAGE-C2, a cancer/testis tumor-associated antigen (CT-TAA), is overexpressed by a variety of cancer cell types."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1947989", "l": "Colony (cells or organisms)", "d": []}, {"i": "NCIT:C61515", "l": "Colony", "d": ["A group of cells or organisms grown from a single progenitor."]}]}
{"type": "biolink:Cell", "ic": "92.728541327098611", "identifiers": [{"i": "CL:0002060", "l": "melanophage", "d": ["A melanin-containing macrophage that obtains the pigment by phagocytosis of melanosomes."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5420597", "l": "Mixed Adherent Cells in Suspension", "d": []}, {"i": "NCIT:C174118", "l": "Mixed Adherent Cells in Suspension", "d": ["A sample comprised of a mixture of cells or clumps of cells, which may have been isolated from normal or tumor tissues, that are maintained in a suspension culture."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1267971", "l": "Lymphocyte positive for CD79B antigen", "d": []}, {"i": "SNOMEDCT:117411006", "d": []}]}
{"type": "biolink:Cell", "ic": "64.964849134614497", "identifiers": [{"i": "CL:0000028", "l": "CNS neuron (sensu Nematoda and Protostomia)", "d": []}]}
{"type": "biolink:Cell", "ic": "89.347505587204751", "identifiers": [{"i": "UMLS:C1513124", "l": "Meningothelial Cell with Clear Cytoplasm", "d": []}, {"i": "NCIT:C37160", "l": "Meningothelial Cell with Clear Cytoplasm", "d": []}]}
{"type": "biolink:Cell", "ic": "89.347505587204751", "identifiers": [{"i": "CL:0000964", "l": "Bm2' B cell", "d": ["A germinal center B cell that founds a germinal center, and has the phenotype IgD-positive, CD38-positive, and CD23-negative."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2608015", "l": "Platelets.large", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5417935", "l": "Obecabtagene autoleucel", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0483192", "l": "CD5+CD2-", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5180578", "l": "Segmented neutrophils | Pleural fluid | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4704950", "l": "Adipose-Derived Mesenchymal Stem Cells", "d": []}]}
{"type": "biolink:Cell", "ic": "60.735851798688778", "identifiers": [{"i": "CL:0001201", "l": "B cell, CD19-positive", "d": ["A B cell that is CD19-positive."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0483187", "l": "CD19+SmIg lambda+", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002534", "l": "mature CD16-positive myeloid dendritic cell", "d": ["A mature CD16-positive myeloid dendritic cell is CD80-high, CD83-positive, CD86-high, and MHCII-high."]}]}
{"type": "biolink:Cell", "ic": "78.435418415656045", "identifiers": [{"i": "UMLS:C2699839", "l": "EBV-Transformed Mature B-Lymphocyte", "d": []}, {"i": "NCIT:C80283", "l": "EBV-Transformed Mature B-Lymphocyte", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0009061", "l": "intestinal crypt stem cell of anorectum", "d": ["An intestinal crypt stem cell that is located in the anorectum."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5557524", "l": "BCMA-specific Universal CAR-expressing T-lymphocytes LCAR-BCX", "d": []}, {"i": "NCIT:C178575", "l": "BCMA-specific Universal CAR-expressing T-lymphocytes LCAR-BCX", "d": ["A preparation of universal T-lymphocytes that have been genetically modified to express a chimeric antigen receptor (CAR) targeting the tumor-associated antigen (TAA) B-cell maturation antigen (BCMA), with potential immunostimulating and antineoplastic activities. Upon intravenous administration, BCMA-specific universal CAR-expressing T-lymphocytes LCAR-BCX are directed to cells expressing BCMA and induce selective toxicity in BCMA-expressing tumor cells. BCMA, a receptor for both a proliferation-inducing ligand (APRIL) and B-cell activating factor (BAFF), is a member of the tumor necrosis factor receptor superfamily (TNFRSF) and plays a key role in plasma cell survival. BCMA is overexpressed on malignant plasma cells."]}]}
{"type": "biolink:Cell", "ic": "92.728541327098611", "identifiers": [{"i": "CL:0005011", "l": "renal alpha-intercalated cell", "d": ["A cuboidal epithelial cell of the kidney which secretes acid and reabsorbs base to regulate acid/base balance."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:4023068", "l": "thalamic excitatory neuron", "d": ["An excitatory neuron that has its soma located in the thalamic complex."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5220579", "l": "Erythrocyte clumps|Urine/Urine sed", "d": []}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "CL:1000715", "l": "kidney cortex collecting duct intercalated cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4740249", "l": "100 cells.CD33", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5237177", "l": "Autologous gamma-globinG16D/sh RNA734 Gene-transduced CD34-positive Cells CSL200", "d": []}, {"i": "NCIT:C165434", "l": "Autologous gamma-globinG16D/sh RNA734 Gene-transduced CD34-positive Cells CSL200", "d": ["A preparation of autologous, CD34-positive hematopoietic stem cells (HSCs) transduced ex vivo with a lentiviral vector encoding for an engineered form of human gamma-globin (hemoglobin-gamma) gene, gamma-globin G16D, and a short-hairpin (sh) RNA734, with potential to restore gamma-globin expression and function. Autologous CD34-positive stem cells are isolated from the patient's own bone marrow and the cells are transduced with the lentiviral vector. Upon re-infusion of the CD34-positive cells back into the patient, these cells express gamma-globinG16D, thereby replacing defective beta globin chains with gamma globin chains allowing the body to make fetal hemoglobin (HbF) and thus healthy red blood cells with a greater oxygen-carrying capacity. Gamma-globin comprises the gamma-chain of HbF; reactivation of HbF in disorders where beta-globin is defective in adult hemoglobin (HbA), such as sickle cell disease and beta thalassemia, may ameliorate these conditions. The G16D form of gamma-globin has increased anti-sickling activity compared to the wild type protein. The shRNA734 is used for positive gene selection."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C3652652", "l": "indium (111In) tropolonate labelled cells", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C3900002", "l": "Autologous CD8+ Melanoma Specific T Cells", "d": []}, {"i": "NCIT:C116072", "l": "Autologous CD8+ Melanoma Specific T Cells", "d": ["Autologous CD8 T-lymphocytes against melanoma-associated antigens, with potential immunomodulating and antineoplastic activities. Following leukapheresis and the ex vivo expansion of cytotoxic T-lymphocytes, the autologous CD8+ melanoma specific T-cells are re-introduced into the melanoma patient. These cytotoxic T-cells recognize and kill the patient's own melanoma cells."]}]}
{"type": "biolink:Cell", "ic": "80.17194633000733", "identifiers": [{"i": "UMLS:C1514091", "l": "Neoplastic Small Neuroepithelial Cell", "d": []}, {"i": "NCIT:C41835", "l": "Neoplastic Small Neuroepithelial Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1516687", "l": "Coactivated T Cell", "d": []}, {"i": "NCIT:C12941", "l": "Coactivated T Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "UMLS:C0007658", "l": "Cementoblasts", "d": []}, {"i": "NCIT:C32274", "l": "Cementoblast", "d": ["A large cell ranging in shape from cuboidal to squamous with a large central nucleus. The nucleus usually has a single nucleolus, which is active in the formation of cementum."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002281", "l": "type S enteroendocrine cell", "d": ["Scattered in duodenojejunal mucosa, this enteroendocrine cell secretes secretin and serotonin."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5180939", "l": "Sickle cells | Blood | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002237", "l": "luminal epithelial cell of prostatic duct", "d": ["A cell that constitutes the luminal layer of epithelium of prostatic duct."]}]}
{"type": "biolink:Cell", "ic": "76.857431420584163", "identifiers": [{"i": "CL:0000677", "l": "gut absorptive cell", "d": ["Cell of the intestinal epithelium with a brush border made up of many parallel packed microvilli; associated with absorption, particularly of macromolecules."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5163548", "l": "Epithelial cells.extrarenal | Urine sediment | Urinalysis", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1267827", "l": "T lymphocyte positive for both CD8 antigen and CD11a antigen", "d": []}, {"i": "SNOMEDCT:115413008", "d": []}]}
{"type": "biolink:Cell", "ic": "78.435418415656045", "identifiers": [{"i": "CL:0001034", "l": "cell in vitro", "d": ["A cell that is maintained or propagated in a controlled artificial environment for use in an investigation."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0882840", "l": "CD3- CD16+ cells", "d": []}]}
{"type": "biolink:Cell", "ic": "82.076046914303362", "identifiers": [{"i": "UMLS:C1708897", "l": "Malignant Ovoid to Spindle-Shaped Fibrohistiocytic Cell", "d": []}, {"i": "NCIT:C49067", "l": "Malignant Ovoid to Spindle-Shaped Fibrohistiocytic Cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4518172", "l": "Population of all fetal erythrocytes in portion of fluid", "d": []}, {"i": "SNOMEDCT:725441003", "d": []}]}
{"type": "biolink:Cell", "ic": "72.79108406015925", "identifiers": [{"i": "CL:0000462", "l": "adepithelial cell", "d": ["A cell of mesodermal origin that is closely associated with the epithelium of an imaginal disc. It is a precursor of some of the insect's adult muscles."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5171872", "l": "Macrophages | Vitreous fluid | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:4023094", "l": "tufted pyramidal neuron", "d": ["A pyramidal neuron which has a distinctive tuft formation, distal from the soma."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5707014", "l": "STING-dependent Activators-loaded Autologous Leukemic Cells", "d": []}, {"i": "NCIT:C187299", "l": "STING-dependent Activators-loaded Autologous Leukemic Cells", "d": ["A preparation of autologous ultraviolet (UV)-irradiated leukemic cells loaded with STING-dependent activators (STAVs), with potential immunomodulating and antineoplastic activities. Upon intravenous administration of STAVs-loaded autologous leukemic cells, the STAVs activates STING-mediated signaling pathways. This activates the immune response through the activation of certain immune cells, including dendritic cells (DCs), which induces the expression of cytokines and chemokines, and leads to an antigen-specific T-cell mediated immune response against the patient's own leukemic cells. STING, a transmembrane protein that activates immune cells in the tumor microenvironment (TME), plays a key role in the activation of the innate immune system. By using the patient's own irradiated cancer cells as antigens, the patient's immune system is exposed to the entire repertoire of this individual's tumor-associated antigens (TAAs)."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C3640216", "l": "TIL 1383I T Cell Receptor-Transduced Autologous T Cells", "d": []}, {"i": "NCIT:C101787", "l": "TIL 1383I T Cell Receptor-Transduced Autologous T Cells", "d": ["Autologous peripheral blood lymphocytes-derived T cells transduced with a retroviral encoding TIL 1383I, a T cell receptor (TCR) specific for melanoma antigen tyrosinase, with potential immunostimulating and antineoplastic activity. After transduction, expansion in culture, and reintroduction into the patient, TIL 1383I TCR-transduced autologous T cells bind to tumor cells expressing tyrosinase, which may induce cytokine expression, activation and proliferation of T-cells, and a specific cytotoxic T-lymphocyte (CTL) response against tyrosinase-expressing tumor cells. TIL 1383I TCR originated from a melanoma patient's CD4+ tumor-infiltrating lymphocytes and is reactive against a class I MHC (HLA-A2)-restricted epitope (368-376) of tyrosinase."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5400052", "l": "Anti-CD19-CAR Genetically Engineered Autologous T Lymphocytes JCAR017", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5181345", "l": "Spermatozoa Agglutinated | Semen | Fertility testing", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1513017", "l": "Maturation-Stage Ameloblast", "d": []}, {"i": "NCIT:C33057", "l": "Maturation-Stage Ameloblast", "d": ["A short columnar epithelial cell that has deposited enamel and has lost organic material and water. It deposits calcium and phosphorus into the enamel matrix. The maturation-stage ameloblast produces and secretes small amounts of proteins."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1524111", "l": "Erythrocyte (RBC) (MMHCC)", "d": []}, {"i": "NCIT:C22566", "l": "Mouse Erythrocyte", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1440361", "l": "Cells.CD83", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5557411", "l": "CRISPR-Cas9 Engineered TGFbRII-deleted Anti-EGFR CAR T-cells", "d": []}, {"i": "NCIT:C182002", "l": "CRISPR-Cas9 Engineered TGFbRII-deleted Anti-EGFR CAR T-cells", "d": ["A preparation of human T-lymphocytes genetically engineered to express an anti-epidermal growth factor receptor (EGFR) chimeric antigen receptor (CAR) gene and gene-edited with the clustered regularly interspaced short palindromic repeats (CRISPR)-Cas9 nuclease complex to disrupt expression of transforming growth factor-beta receptor II (TGFbRII), with potential immunostimulatory and antineoplastic activities. Upon administration, the CRISPR-Cas9 engineered TGFbRII-deleted anti-EGFR CAR T-cells target and bind to the EGFR antigen on tumor cell surfaces; subsequently, EGFR-expressing tumor cells may be lysed. EGFR, overexpressed by a variety of cancer cell types, plays a key role in tumor cell proliferation, tumor angiogenesis and radio- and chemoresistance. By knocking out the expression of TGFbRII, the immunosuppressive cytokine TGF-beta is unable to bind to the T-cells and prevent the activation of the T-cells. TGF-beta contributes to the immunosuppressive nature of the tumor microenvironment (TME), and plays a key role in promoting tumor initiation, metastasis, and suppressing anti-tumor immunity."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0333767", "l": "Lobulated fibers", "d": []}, {"i": "SNOMEDCT:62655004", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C4744618", "l": "Autologous Anti-CD19CAR-CD3zeta-4-1BB-IL-15-PD1-expressing Tri-functional T-lymphocytes", "d": []}, {"i": "NCIT:C156169", "l": "Autologous Anti-CD19CAR-CD3zeta-4-1BB-IL-15-PD1-expressing Tri-functional T-lymphocytes", "d": ["A preparation of autologous T-lymphocytes engineered to express a tri-functional chimeric antigen receptor (CAR) specific for the tumor-associated antigen (TAA) cluster of differentiation 19 (CD19), and an extracellular domain consisting of interleukin 15 (IL-15) and programmed cell death 1 (PD1; PDCD1; CD279; programmed death-1), linked to the intracellular signaling domains of 4-1BB (CD137) and the zeta chain of the TCR/CD3 complex (TCRzeta; CD247; CD3zeta), with potential antineoplastic activity. Upon intravenous administration, autologous anti-CD19CAR-CD3zeta-4-1BB-IL-15-PD1-expressing tri-functional T-lymphocytes target, bind to, and induce selective toxicity in CD19-expressing tumor cells. IL-15 is a pro-survival cytokine that promotes T-cell persistence and potentiates the immune response against tumor cells. The PD1 moiety binds to programmed cell death-1 ligand 1 (PD-L1; cluster of differentiation 274; CD274) on tumor cells, reversing T-cell inactivation caused by endogenous PD1/PD-L1 signaling and enhancing the cytotoxic T-lymphocyte (CTL)-mediated anti-tumor immune response against PD-L1-expressing tumor cells. CD19 is a B-cell-specific cell surface antigen overexpressed in B-cell lineage tumors. Incorporation of the costimulatory signaling domains increases human T-cell function, expansion, and survival."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0682697", "l": "Golgi type II neuron", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5155165", "l": "Blasts | Blood | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0314585", "l": "Diffusion chamber colony-forming unit", "d": []}, {"i": "SNOMEDCT:445324003", "d": []}]}
{"type": "biolink:Cell", "ic": "62.116924269856", "identifiers": [{"i": "UMLS:C1513943", "l": "Neoplastic Connective and Soft Tissue Spindle Cell", "d": []}, {"i": "NCIT:C36954", "l": "Neoplastic Connective and Soft Tissue Spindle Cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157420", "l": "CD3 blasts | Blood | Cell markers", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C3178786", "l": "Noradrenergic Neurons", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C4287718", "l": "Cord Blood-derived Expanded Natural Killer Cells PNK-007", "d": []}, {"i": "NCIT:C128560", "l": "Cord Blood-derived Expanded Natural Killer Cells PNK-007", "d": ["A population of allogeneic lytic natural killer (NK) cells derived from human umbilical cord blood (UCB), with potential cytotoxic activity. Hematopoietic stem cells (HSC) are isolated from human UCB; this is followed by ex vivo differentiation into mature, highly lytic, NK cells, and expansion. Upon administration, the CB-derived expanded NK cells PNK-007 may lyse cancer cells."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5446453", "l": "Autologous BCL11A-disrupted Human Hematopoietic Stem and Progenitor Cells HIX763", "d": []}, {"i": "NCIT:C175343", "l": "Autologous BCL11A-disrupted Human Hematopoietic Stem and Progenitor Cells HIX763", "d": ["A population of autologous human hematopoietic stem and progenitor cells (HSPCs) that are genetically modified to disrupt the activity of B-cell lymphoma/leukemia 11A (BCL11A), with potential usage for transplantation in patients with sickle cell disease (SCD). Upon infusion into the patient, the autologous BCL11A-disrupted HSPCs HIX763 can populate the bone marrow and differentiate into a variety of blood cell types including lymphoid cells, myeloid cells and erythroblasts. As BCL11A is a suppressor of fetal hemoglobin (HbF; hemoglobin F) expression, disruption of the expression of BCL11A stimulates the expression of HbF in erythrocytes that differentiate from HIX763. HbF may compensate for reduced or absent expression of adult hemoglobin (Hb) in patients with SCD. HbF is a form of the oxygen carrying Hb that is naturally present at birth and is then replaced by the adult form of hemoglobin."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2329553", "l": "Enterocyte of epithelium proper of ileum", "d": []}]}
{"type": "biolink:Cell", "ic": "84.75972595860604", "identifiers": [{"i": "CL:0002048", "l": "late pro-B cell", "d": ["A pre-B cell precursor is CD19-low, CD22-positive , CD34-positive, CD38-positive."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1267932", "l": "Lymphocyte positive for CD45RO antigen", "d": []}, {"i": "SNOMEDCT:117375005", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1267879", "l": "Lymphocyte positive for CD16B antigen", "d": []}, {"i": "SNOMEDCT:117556001", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5557245", "l": "Allogeneic Human T Cell Progenitors SMART 101", "d": []}, {"i": "NCIT:C181750", "l": "Allogeneic Human T Cell Progenitors SMART 101", "d": ["A preparation of allogeneic human T cell progenitor cells, that can potentially be used for immune reconstitution purposes. Upon administration, the allogeneic human T cell progenitors SMART 101 may accelerate immune reconstitution after T cell depleted allogeneic hematopoietic stem cell transplantation (HSCT) in patients with relapsed/refractory acute leukemia."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5222947", "l": "CD3- CD16+ cells/100 cells in tissue", "d": []}]}
{"type": "biolink:Cell", "ic": "80.869303025598512", "identifiers": [{"i": "CL:2000021", "l": "sebaceous gland cell", "d": ["Any native cell that is part of a sebaceous gland."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1267867", "l": "Lymphocyte positive for CD11B antigen", "d": []}, {"i": "SNOMEDCT:117548004", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1267812", "l": "Lymphoblast positive for CD2 antigen", "d": []}, {"i": "SNOMEDCT:117515004", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1545227", "l": "Cells.CD3+CD56+/100 cells", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157927", "l": "Cells | Urine sediment | Urinalysis", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1515968", "l": "Anaplastic Melanocyte", "d": []}, {"i": "NCIT:C37110", "l": "Anaplastic Melanocyte", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5160676", "l": "Columnar cells/100 cells | Bronchial | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "UMLS:C1513941", "l": "Neoplastic Clear Cell Oncocyte", "d": []}, {"i": "NCIT:C36939", "l": "Neoplastic Clear Cell Oncocyte", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002061", "l": "T-helper 9 cell", "d": ["A T-helper cell that is characterized by secreting interleukin 9 and responding to helminth infections. This cell-type can derives from Th2 cells in the presence of TGF-beta and IL-4. Th2 cytokine production is surpressed."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5572242", "l": "Leukocytes | Bronchoalveolar lavage | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1267832", "l": "Lymphocyte positive for both CD3 antigen and CD69 antigen", "d": []}, {"i": "SNOMEDCT:117523002", "d": []}]}
{"type": "biolink:Cell", "ic": "89.347505587204751", "identifiers": [{"i": "CL:0002212", "l": "type II muscle cell", "d": ["A fast muscle fiber cell that stores energy in the form of glycogen and creatine phosphate."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1267925", "l": "Lymphocyte positive for CD43 antigen", "d": []}, {"i": "SNOMEDCT:117369001", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5216227", "l": "Leukocytes other|NCnc|Pt|Periton fld", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1440375", "l": "Cells.CD99", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C3641721", "l": "Naive T-Lymphocyte", "d": []}, {"i": "NCIT:C104081", "l": "Naive T-Lymphocyte", "d": ["A mature T-lymphocyte that has differentiated in the bone marrow and undergone central tolerance selection in the thymus but has not interacted with its cognate antigen. These cells are characterized by the presence of the T-cell receptor, L-selectin and the IL-7 receptor and the absence of CD25, CD44, CD69 and CD45R0."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0000246", "l": "Mauthner neuron", "d": []}]}
{"type": "biolink:Cell", "ic": "92.728541327098611", "identifiers": [{"i": "UMLS:C1317511", "l": "Lymphocytes.immunoblastic", "d": []}, {"i": "NCIT:C34032", "l": "Immunoblast", "d": ["An antigenically stimulated lymphocyte. It is a large cell with well-defined cytoplasm, a large nucleus with prominent nuclear membrane, distinct nucleoli, and clumped chromatin."]}, {"i": "SNOMEDCT:725672006", "d": []}]}
{"type": "biolink:Cell", "ic": "46.326930142806837", "identifiers": [{"i": "CL:0000187", "l": "muscle cell", "d": ["A mature contractile cell, commonly known as a myocyte. This cell has as part of its cytoplasm myofibrils organized in various patterns."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2331938", "l": "Diploid nucleated cell", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5555822", "l": "HER-2/PD-L1-targeting CAR-T Cells", "d": []}, {"i": "NCIT:C179621", "l": "HER-2/PD-L1-targeting CAR-T Cells", "d": ["A preparation of T-lymphocytes that have been genetically modified to express chimeric antigen receptors (CARs) targeting the tumor-associated antigens (TAAs) human epidermal growth factor 2 (HER2; ErbB2; HER-2) and the immunosuppressive ligand programmed cell death-1 ligand 1 (PD-L1; cluster of differentiation 274; CD274), with potential immunostimulating and antineoplastic activities. Upon administration, anti-HER2/anti-PD-L1 CAR T-cells target and bind to HER2- and PD-L1-expressing tumor cells, thereby inducing selective toxicity in HER2- and PD-L1-expressing tumor cells. HER2 is overexpressed in a variety of cancer cell types and is associated with increased tumor cell proliferation. PD-L1 is overexpressed by many human cancer cell types and plays a key role in the downregulation of the immune system and tumor evasion from host immunity."]}]}
{"type": "biolink:Cell", "ic": "89.347505587204751", "identifiers": [{"i": "CL:1000217", "l": "growth plate cartilage chondrocyte", "d": []}]}
{"type": "biolink:Cell", "ic": "88.140761698499901", "identifiers": [{"i": "UMLS:C0229545", "l": "Pituicyte", "d": []}, {"i": "NCIT:C45919", "l": "Pituicyte", "d": ["A cell of the neural lobe of the hypophysis. It has long branching processes and resembles neuroglia. It secretes antidiuretic hormone."]}, {"i": "SNOMEDCT:29708002", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157546", "l": "CD4+CD45RA+CD45RB+CD45RC+ cells | Bone marrow | Cell markers", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5171664", "l": "Lymphocytes | Peritoneal fluid | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157667", "l": "CD8+CD25+ cells | Blood | Cell markers", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C4763556", "l": "Autologous CT-RCC-1 HERV-E-TCR-transduced-HLA-A11-restricted CD8+/CD34t+ T-cells", "d": []}, {"i": "NCIT:C157344", "l": "Autologous CT-RCC-1 HERV-E-TCR-transduced-HLA-A11-restricted CD8+/CD34t+ T-cells", "d": ["A preparation of autologous T-lymphocytes transduced with a retroviral vector encoding a T-cell receptor (TCR) sequence specific for CT-RCC-1, a tumor-associated antigen (TAA) and HLA-A11-restricted peptide encoded by human endogenous retrovirus (HERV) type E as well as a truncated CD34 chain (CD34t), with potential antineoplastic activity. Upon isolation, transduction, expansion ex vivo and re-introduction into the patient, the autologous CT-RCC-1 HERV-E-TCR-transduced-HLA-A11-restricted CD8+/CD34t+ T-cells bind to and induce selective toxicity in tumor cells expressing both the HLA-A11 allele and the CT-RCC-1 HERV-E antigen. The CD34t protein allows the transduced cells to be identified with an anti-CD34 antibody, and facilitates monitoring of the genetically modified T-cells following adoptive transfer. CT-RCC-1 HERV-E is a TAA found in a high percentage of clear cell renal cell carcinoma (ccRCC) cells."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5571672", "l": "Leukocytes|NCnc|Pt|BAL", "d": []}]}
{"type": "biolink:Cell", "ic": "58.973714123956164", "identifiers": [{"i": "UMLS:C1518275", "l": "Neuroendocrine Cells", "d": []}, {"i": "NCIT:C12485", "l": "Neuroendocrine Cell", "d": ["An endocrine cell that produces and releases hormones and regulatory proteins such as neurotransmitters and neuropeptide hormones. This type of cell enables autocrine communication with paracrine and endocrine cells throughout the body."]}, {"i": "MESH:D055099", "l": "Neuroendocrine Cells", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1510808", "l": "Adipocyte with Nuclear Atypia", "d": []}, {"i": "NCIT:C36978", "l": "Adipocyte with Nuclear Atypia", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0019028", "l": "midzonal region hepatocyte", "d": ["Any hepatocyte that is part of the liver lobule midzonal region. These cells have mixed functionality in comparison with those in the other two regions of the liver lobule."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C4050617", "l": "Autologous HPV-16/18 E6/E7-specific TGF-beta-resistant T Lymphocytes", "d": []}, {"i": "NCIT:C121537", "l": "Autologous HPV-16/18 E6/E7-specific TGF-beta-resistant T Lymphocytes", "d": ["A preparation of autologous transforming growth factor-beta (TGF-beta)-resistant cytotoxic T-lymphocytes (CTL) reactive to human papilloma virus (HPV) types 16 and 18 E6/E7 antigens, with potential antineoplastic activity. Autologous T-lymphocytes from a HPV-positive cancer patient are exposed to and stimulated with dendritic cells (DCs) loaded with the HPV-16/18 proteins E6 and E7. In turn, the HPV-16/18 E6/E7-specific T-lymphocytes are transduced with a retroviral vector expressing a dominant-negative mutant of type II transforming growth factor (TGF)-beta receptor, which blocks signaling mediated by all three TGF-beta isoforms. Following re-administration to patients with HPV-positive tumors, the HPV-16/18 E6/E7-specific TGF-beta-resistant T lymphocytes target HPV16/18 E6/E7-positive cells, which may result in a specific cytotoxic T-lymphocyte (CTL) response, followed by cell lysis and the inhibition of tumor cell proliferation. Tumors expressing TGF-beta inhibit T-lymphocyte activation and expansion."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4245839", "l": "Set of specialized cardiac muscle cells", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:4033007", "l": "brush cell of epithelium of lobar bronchus", "d": ["A(n) brush cell that is part of a(n) epithelium of lobar bronchus."]}]}
{"type": "biolink:Cell", "ic": "48.734767010472297", "identifiers": [{"i": "UMLS:C1510725", "l": "Abnormal Hematopoietic and Lymphoid Cell", "d": []}, {"i": "NCIT:C36987", "l": "Abnormal Hematopoietic and Lymphoid Cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2337234", "l": "Suppressor enhancer T lymphocyte", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:1000470", "l": "myoepithelial cell of primary lactiferous duct", "d": ["A myoepithelial cell that is part of the primary lactiferous duct."]}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "CL:0002023", "l": "CD34-positive, CD41-positive, CD42-positive megakaryocyte progenitor cell", "d": ["A megakaroycotye progenitor cell that is CD34-positive, CD41-positive and CD42-positive on the cell surface."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157320", "l": "CD15 cells | Blood | Cell markers", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5160255", "l": "Clue cells | XXX | Microbiology", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0009045", "l": "B cell of medullary sinus of lymph node", "d": ["A B cell found in the lymph node medullary sinus."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5556468", "l": "Short Hairpin RNA-IL-6 Gene Silencing Anti-CD19 CAR T Cells", "d": []}, {"i": "NCIT:C180570", "l": "Short Hairpin RNA-IL-6 Gene Silencing Anti-CD19 CAR T Cells", "d": ["A preparation of T-lymphocytes that have been genetically modified to express a chimeric antigen receptor (CAR) targeting the tumor-associated antigen (TAA) CD19 and containing a short hairpin RNA (shRNA) against the pro-inflammatory cytokine interleukin-6 (IL-6), and linked to the intracellular signaling domains of 4-1BB (CD137) and the zeta chain of the TCR/CD3 complex (TCRzeta; CD247; CD3zeta), with potential immunostimulating and antineoplastic activities. Upon administration, short hairpin RNA-IL-6 gene silencing anti-CD19 CAR T cells target and bind to CD19-expressing tumor cells, thereby inducing selective toxicity in CD19-expressing tumor cells. CD19 antigen is a B-cell specific cell surface antigen expressed in all B-cell lineage malignancies. IL-6 gene silencing reduces IL-6 gene expression and release. This may inhibit IL-6-mediated toxicity due to high IL-6 levels and may prevent severe cytokine release syndrome (CRS) and CAR-T-related encephalopathy (CRES)."]}]}
{"type": "biolink:Cell", "ic": "51.32742590898966", "identifiers": [{"i": "CL:0000763", "l": "myeloid cell", "d": ["A cell of the monocyte, granulocyte, mast cell, megakaryocyte, or erythroid lineage."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1979641", "l": "Blast cell positive for CD24 antigen", "d": []}, {"i": "SNOMEDCT:724264006", "d": []}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "UMLS:C1511449", "l": "Mouse Spinal Cord Neuron", "d": []}, {"i": "NCIT:C22626", "l": "Mouse Spinal Cord Neuron", "d": []}]}
{"type": "biolink:Cell", "ic": "92.728541327098611", "identifiers": [{"i": "CL:0002340", "l": "luminal cell of prostate epithelium", "d": ["The exocrine cell of the prostate, this epithelial cell secretes prostatic acid phosphotase and PSA, and is dependent on androgen hormones for survival."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2964631", "l": "100 cells.CD34", "d": []}]}
{"type": "biolink:Cell", "ic": "82.076046914303362", "identifiers": [{"i": "CL:4023046", "l": "L6b glutamatergic neuron of the primary motor cortex", "d": ["An excitatory glutamatergic neuron transcriptomically related to the CT subclass, with a soma preferentially located in the bottom of L6 of the primary motor cortex."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5163722", "l": "Erythrocytes | Pleural fluid | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0333863", "l": "Dysplastic platelet", "d": []}, {"i": "SNOMEDCT:25624002", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C0427528", "l": "Atypical mononuclear cell", "d": []}, {"i": "NCIT:C12979", "l": "Atypical Mononuclear Cell", "d": []}, {"i": "SNOMEDCT:250287000", "d": []}]}
{"type": "biolink:Cell", "ic": "92.728541327098611", "identifiers": [{"i": "CL:0002166", "l": "epithelial cell of Malassez", "d": ["An epithelial cell that remains from the disintegration of the epithelial root sheath involved in the development of teeth."]}]}
{"type": "biolink:Cell", "ic": "89.347505587204751", "identifiers": [{"i": "CL:1001016", "l": "kidney loop of Henle ascending limb epithelial cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157465", "l": "CD3+HLA-DR+ cells | Blood | Cell markers", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C4687729", "l": "Anti-NY-ESO-1 TCR LV-transduced Autologous T-Cells TAEST16001", "d": []}, {"i": "NCIT:C147135", "l": "Anti-NY-ESO-1 TCR LV-transduced Autologous T-Cells TAEST16001", "d": ["A preparation of human autologous T-lymphocytes that are transduced with a lentiviral vector (LV) encoding an affinity-enhanced T-cell receptor (TCR) specific for the cancer-testis antigen NY-ESO-1, with potential immunostimulating and antineoplastic activities. Upon isolation, transduction, expansion ex vivo, and reintroduction into the patient, the anti-NY-ESO-1 TCR LV-transduced autologous T-cells TAEST16001 recognize and bind to NY-ESO-1-overexpressing tumor cells. This may result in a specific cytotoxic T-lymphocyte (CTL)-mediated killing of NY-ESO-1-positive tumor cells. NY-ESO-1, a tumor-associated antigen (TAA), is found in normal testis and on the surface of various tumor cell types, and is not, or is minimally, expressed in normal, healthy cells."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2332713", "l": "Type I enteroendocrine cell", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0004245", "l": "indoleamine-accumulating amacrine cell", "d": ["An amacrine cell with a wide dendritic field and post-synaptic terminals in S5. This cell type releases the neurotransmitters gamma-aminobutyric acid (GABA) and serotonin."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C2346937", "l": "Malignant Ovoid Osteoblast", "d": []}, {"i": "NCIT:C67522", "l": "Malignant Ovoid Osteoblast", "d": []}]}
{"type": "biolink:Cell", "ic": "88.140761698499901", "identifiers": [{"i": "UMLS:C1517809", "l": "Leukemic Medium-Sized B-Lymphocyte with Basophilic Cytoplasm", "d": []}, {"i": "NCIT:C41068", "l": "Leukemic Medium-Sized B-Lymphocyte with Basophilic Cytoplasm", "d": []}]}
{"type": "biolink:Cell", "ic": "70.216808612803263", "identifiers": [{"i": "UMLS:C1881580", "l": "Malignant Neuroendocrine Small Round Cell", "d": []}, {"i": "NCIT:C47805", "l": "Malignant Neuroendocrine Small Round Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5206130", "l": "Autologous PRAME-targeting TCR-engineered T-cells IMA203", "d": []}, {"i": "NCIT:C161831", "l": "Autologous TCR-engineered T-cells IMA203", "d": ["A preparation of autologous T-lymphocytes that are genetically modified with a viral vector encoding a T-cell receptor (TCR) targeting an as of yet undisclosed patient-specific tumor associated antigen (TAA), with potential antineoplastic activity. Upon intravenous administration back into the patient, the autologous TCR-engineered T-cells IMA203 specifically recognize and bind to the TAA on cancer cells, which induces a cytotoxic T-lymphocyte (CTL)-mediated immune response against the TAA-positive cancer cells."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4318752", "l": "CD5+ T lymphocyte", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1171346", "l": "Human Embryonic Stem Cells", "d": []}, {"i": "MESH:D000066449", "l": "Human Embryonic Stem Cells", "d": []}]}
{"type": "biolink:Cell", "ic": "87.120474278337809", "identifiers": [{"i": "UMLS:C1517107", "l": "Faggot Cell", "d": []}, {"i": "NCIT:C37052", "l": "Faggot Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "89.347505587204751", "identifiers": [{"i": "UMLS:C1514042", "l": "Neoplastic Natural Killer Cell", "d": []}, {"i": "NCIT:C36994", "l": "Neoplastic Natural Killer Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C4684970", "l": "Anti-CD19-CD20-CAR-CD3zeta-4-1BB-expressing Autologous T-lymphocytes", "d": []}, {"i": "NCIT:C143156", "l": "Anti-CD19-CD20-CAR-CD3zeta-4-1BB-expressing Autologous T-lymphocytes", "d": ["Autologous T-lymphocytes that have been transduced with a lentiviral vector to express a chimeric antigen receptor (CAR) consisting of a single chain variable fragment (scFv) of anti-CD19 in tandem with an anti-CD20 scFv, and coupled to the cytoplasmic portion of the zeta chain of the human T-cell receptor (CD3zeta), and the co-stimulatory molecule 4-1BB (CD137), with potential immunostimulating and antineoplastic activities. Upon transfusion, anti-CD19-CD20-CAR-CD3zeta-4-1BB-expressing autologous T-lymphocytes recognize and direct T-cells to CD19- or CD20-expressing tumor B-cells. This results in a cytotoxic T-lymphocyte (CTL) response against CD19- or CD20-expressing tumor cells, and causes tumor cell lysis. Both CD19 and CD20 are B-cell-specific cell surface antigens overexpressed in B-cell lineage malignancies."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:1000284", "l": "smooth muscle fiber of descending colon", "d": ["A smooth muscle cell that is part of the descending colon."]}]}
{"type": "biolink:Cell", "ic": "88.140761698499901", "identifiers": [{"i": "CL:0002144", "l": "capillary endothelial cell", "d": ["An endothelial cell found in capillaries."]}]}
{"type": "biolink:Cell", "ic": "73.847638787057321", "identifiers": [{"i": "UMLS:C4745055", "l": "Malignant Basal Cell", "d": []}, {"i": "NCIT:C156768", "l": "Malignant Basal Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C2985194", "l": "E. coli CD-expressing Genetically Modified Neural Stem Cells", "d": []}, {"i": "NCIT:C92585", "l": "E. coli CD-expressing Genetically Modified Neural Stem Cells", "d": ["Genetically-modified neural stem cells (NSCs) transfected with the Escherichia coli (E. coli) suicidal gene cytosine deaminase (CD), with potential antineoplastic adjuvant activity. Upon intracerebral injection, E. coli CD-expressing genetically modified NSCs express the E. coli cytosine deaminase, an enzyme that catalyzes the intracellular conversion of the nontoxic prodrug 5-fluorocytosine (5-FC) into the cytotoxic 5-fluorouracil (5-FU). Co-administration of this agent with 5-FC and upon local activation of 5-FU in the brain tumor, 5-FU disrupts DNA synthesis in tumor cells thereby impeding cellular proliferation with minimal systemic exposure and toxicity."]}]}
{"type": "biolink:Cell", "ic": "84.75972595860604", "identifiers": [{"i": "UMLS:C1709674", "l": "Primitive Mesenchymal Round to Oval Cell", "d": []}, {"i": "NCIT:C48916", "l": "Primitive Mesenchymal Round to Oval Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "92.728541327098611", "identifiers": [{"i": "CL:0000580", "l": "neutrophilic myelocyte", "d": ["A neutrophil precursor in the granulocytic series, being a cell intermediate in development between a promyelocyte and a metamyelocyte; in this stage, production of primary granules is complete and neutrophil-specific granules has started. No nucleolus is present. This cell type is CD13-positive, CD16-negative, integrin alpha-M-positive, CD15-positive, CD33-positive, CD24-positive, C/EBP-a-positive, C/EBPe-positive, PU.1-positive, lactotransferrin-positive, myeloperoxidase-positive and NGAL-positive."]}]}
{"type": "biolink:Cell", "ic": "76.857431420584163", "identifiers": [{"i": "CL:0000549", "l": "basophilic erythroblast", "d": ["A nucleated immature erythrocyte, having cytoplasm generally similar to that of the earlier proerythroblast but sometimes even more basophilic, and usually regular in outline. The nucleus is still relatively large, but the chromatin strands are thicker and more deeply staining, giving a coarser appearance; the nucleoli have disappeared. This cell is CD71-positive and lacks hematopoeitic lineage markers."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0682702", "l": "Cerebellar neuron", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5556527", "l": "Marnetegragene Autotemcel", "d": []}, {"i": "NCIT:C180650", "l": "Marnetegragene Autotemcel", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5206698", "l": "AUTO3", "d": []}, {"i": "NCIT:C162620", "l": "Autologous Anti-CD19/CD22 CAR T-cells AUTO3", "d": ["A preparation of autologous T-lymphocytes that have been transduced with a bicistronic retroviral vector encoding both an anti-CD19 chimeric antigen receptor (CAR) fused to OX40 co-stimulatory domain and an anti-CD22 CAR linked to the intracellular signaling domains of 4-1BB (CD137) and the zeta chain of the TCR/CD3 complex (TCRzeta; CD247; CD3zeta), optimized with a novel pentameric spacer derived from the collagen oligomeric matrix protein (COMP), with potential antineoplastic activity. Upon administration, the autologous anti-CD19/CD22 CAR T-cells AUTO3 bind to and induce selective toxicity in tumor cells expressing CD19 and CD22. CD19 and CD22, both transmembrane phosphoglycoproteins expressed on the surface of cells in the B lineage, are often overexpressed on malignant B-cells. By simultaneously targeting two B-cell antigens, this preparation may minimize relapse due to single antigen loss in patients with B-cell malignancies."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2599885", "l": "Immature neutrophils", "d": []}]}
{"type": "biolink:Cell", "ic": "92.728541327098611", "identifiers": [{"i": "UMLS:C1512551", "l": "Hyperchromatic Stromal Cell", "d": []}, {"i": "NCIT:C36980", "l": "Hyperchromatic Stromal Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "74.953330836288131", "identifiers": [{"i": "CL:0000696", "l": "PP cell", "d": ["A cell that stores and secretes pancreatic polypeptide hormone."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2322965", "l": "Set of all cells", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5186823", "l": "Monocytes | Fetus | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "ic": "90.82444074280258", "identifiers": [{"i": "UMLS:C0506994", "l": "Goblet Cells", "d": []}, {"i": "NCIT:C12586", "l": "Goblet Cell", "d": ["A mucin-producing and -secreting epithelial cell found mainly in the intestinal and respiratory tracts."]}, {"i": "MESH:D020397", "l": "Goblet Cells", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1522165", "l": "Leukocyte - Myelocyte (Granulocyte) - Basophil - Mast Cell (MMHCC)", "d": []}, {"i": "NCIT:C22594", "l": "Mouse Mast Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "86.236661114203869", "identifiers": [{"i": "CL:4023032", "l": "ON retinal ganglion cell", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1512639", "l": "Immature Platelet", "d": []}, {"i": "NCIT:C13126", "l": "Immature Platelet", "d": ["A young platelet that contains residual mRNA and rRNA when released from the bone marrow into the peripheral circulation as a result of thrombopoiesis. Immature platelets normally make up a small percentage of the total circulating platelets (1.1-6.1%, with a mean of 3.4%.). An increased proportion of immature platelets in blood indicates increased thrombopoiesis. The relationship between the percent of immature platelets and the platelet count can be used to determine the rate of platelet turnover."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5216251", "l": "Lymphocytes|NCnc|Pt|CSF", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5554942", "l": "Autologous PD-1 Nanobody-expressing Anti-MSLN CAR T-cells", "d": []}, {"i": "NCIT:C178316", "l": "Autologous PD-1 Nanobody-expressing Anti-MSLN CAR T-cells", "d": ["A preparation of autologous T-lymphocytes that have been genetically modified to express a nanobody that targets the negative immunoregulatory human cell surface receptor programmed cell death protein 1 (PD-1; PDCD1; CD279) and transduced with a gene encoding a chimeric antigen receptor (CAR) specific for the human tumor-associated antigen (TAA) mesothelin (MSLN), with potential immunomodulating and antineoplastic activities. After isolation, transduction, expansion in culture, and reintroduction into the patient, the autologous PD-1 nanobody-expressing anti-MSLN CAR T-cells specifically target and kill MSLN-expressing tumor cells. The anti-PD-1 expressed on the CAR T-cells binds to PD-1 expressed on T-cells and prevents the interaction of PD-1 with its ligand programmed cell death 1 ligand 1 (PD-L1, PD-1L1; CD274) expressed on tumor cells. This prevents PD-1-mediated signaling and T-cell exhaustion, enhances T-cell activation, and results in enhanced toxicity in MSLN-expressing tumor cells. PD-1, an immunoglobulin (Ig) superfamily transmembrane protein and inhibitory receptor, negatively regulates T-cell activation and overexpression within the tumor microenvironment (TME) and inhibits T-cell function. MSLN, a cell surface glycoprotein involved in cell adhesion, is overexpressed in a variety of cancer cell types."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4323727", "l": "Cardiac neural crest cell", "d": []}]}
{"type": "biolink:Cell", "ic": "89.347505587204751", "identifiers": [{"i": "UMLS:C1180350", "l": "Taste bud cell", "d": []}, {"i": "NCIT:C13147", "l": "Taste Bud Cell", "d": ["Any of the three types of the cells that constitute the taste bud. They are classified as neuroepithelial (sensory) cells, supporting cells, and basal cells."]}]}
{"type": "biolink:Cell", "ic": "92.728541327098611", "identifiers": [{"i": "UMLS:C1708919", "l": "Malignant Stellate Cell", "d": []}, {"i": "NCIT:C53989", "l": "Malignant Stellate Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "89.347505587204751", "identifiers": [{"i": "CL:0000768", "l": "immature basophil", "d": ["Any of the immature forms of a basophil, in which basophilic specific granules are present but other phenotypic features of the mature form may be lacking."]}]}
{"type": "biolink:Cell", "ic": "85.457082654197222", "identifiers": [{"i": "UMLS:C1514112", "l": "Neoplastic T-Prolymphocyte", "d": []}, {"i": "NCIT:C37184", "l": "Neoplastic T-Prolymphocyte", "d": []}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "CL:0000618", "l": "sheath cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1267859", "l": "Lymphocyte positive for both CD8 antigen and HLA-DR antigen", "d": []}, {"i": "SNOMEDCT:116815002", "d": []}]}
{"type": "biolink:Cell", "ic": "83.023198044254755", "identifiers": [{"i": "CL:0001064", "l": "malignant cell", "d": ["A neoplastic cell that is capable of entering a surrounding tissue"]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C4724879", "l": "PD-1 knockout EBV-specific Cytotoxic T Lymphocytes", "d": []}, {"i": "NCIT:C148180", "l": "PD-1 knockout EBV-specific Cytotoxic T Lymphocytes", "d": ["A preparation of Epstein-Barr virus (EBV) reactive cytotoxic T-lymphocytes (CTLs) in which the programmed cell death 1 (PD-1; PDCD1; CD279; programmed death-1) gene is deleted, with potential immunomodulating activity. Upon administration of the PD-1 knockout EBV-specific CTLs, these CTLs target and induce selective toxicity in EBV-positive cancer cells. This results in cell lysis and inhibition of cancer cell proliferation. Expression of PD-1, an inhibitory receptor expressed on activated T-cells, plays a key role in CTL suppression, T-cell exhaustion and CTL apoptosis. PD-1 knockout abrogates T-cell exhaustion and increases T-cell activity and cytotoxicity. EBV, a ubiquitous human herpesvirus, is associated with various cancer cell types."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002289", "l": "type I taste bud cell", "d": ["A densely staining taste receptor cell that contains many dense vacuoles in their apical regions which project into the apical space and bear microvilli. This cell type serves as a supporting cell by surrounding and isolating the other cell types from each other; secrete a dense amorphous material that surrounds the microvilli in the taste pore. This cell type expresses a glial glutumate transporter, GLAST."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5216194", "l": "Basophils|NCnc|Pt|Synv fld", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:4023092", "l": "inverted pyramidal neuron", "d": ["A pyramidal neuron which has an apical tree which is oriented towards the white matter."]}]}
{"type": "biolink:Cell", "ic": "87.120474278337809", "identifiers": [{"i": "CL:0004253", "l": "wide field retinal amacrine cell", "d": ["An amicrine that has a wide dendritic field."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C4687465", "l": "Allogeneic CD123-specific Universal CAR123-expressing T-lymphocytes", "d": []}, {"i": "NCIT:C146806", "l": "Allogeneic CD123-specific Universal CAR123-expressing T-lymphocytes", "d": ["Allogeneic, off-the-shelf, universal transcription activator-like effector nuclease (TALEN)-engineered T-lymphocytes that have been genetically modified to express a chimeric antigen receptor (CAR) targeting the tumor-associated antigen (TAA) human interleukin-3 receptor alpha chain (IL3RA; cluster of differentiation 123; CD123), with potential immunomodulating and antineoplastic activities.  Upon transfusion of allogeneic CD123-specific universal CAR123-expressing T-lymphocytes (UCART123), these cells target and bind to cancer cells expressing CD123. This induces selective toxicity in and causes lysis of CD123-expressing tumor cells. CD123 is normally expressed on committed blood progenitor cells in the bone marrow; its overexpression is associated with both increased leukemic cell proliferation and aggressiveness. Using TALEN technology, the UCART123 cells no longer express the endogenous T-cell receptor (TCR) thereby abrogating the potential induction of graft-versus-host disease (GvHD) by the donor T-cells."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2334042", "l": "Microfold cell of epithelium proper of ileum", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0000926", "l": "CD4-positive type I NK T cell secreting interferon-gamma", "d": ["A mature NK T cell that secretes interferon-gamma and enhances type 1 immune responses."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0933800", "l": "Microvillus columnar cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2326946", "l": "Goblet cell of epithelium of duodenal gland", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1182790", "l": "Epithelial cell of parietal layer of glomerular capsule", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:3000002", "l": "sympathetic noradrenergic neuron", "d": ["Sympathetic noradrenergic neuron."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4322827", "l": "CD22+CD19+ B lymphocyte", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157354", "l": "CD19+CD27+IgD-IgM- cells | Blood | Cell markers", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2328384", "l": "Peripheral blood mesothelial cell", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5206131", "l": "Autologous Anti-CD7 CAR/28zeta CRISPR-edited T-lymphocytes", "d": []}, {"i": "NCIT:C161832", "l": "Autologous Anti-CD7 CAR/28zeta CRISPR-edited T-lymphocytes", "d": ["A preparation of autologous T-lymphocytes (ATL) that have been gene-edited with the clustered regularly interspaced short palindromic repeats (CRISPR)-caspase 9 (Casp9) to remove the CD7 antigen and genetically engineered to express a chimeric antigen receptor (CAR) composed of a single-chain variable fragment (scFv) directed against the CD7 antigen and linked to the co-stimulatory domains of CD28 and the zeta chain of the TCR/CD3 complex (CD3-zeta) (CD28zeta), with potential immunostimulating and antineoplastic activities. Upon administration, the autologous anti-CD7 CAR/28zeta CRISPR-edited T-lymphocytes specifically recognize and bind to CD7-expressing tumor cells, resulting in specific T-cell-mediated tumor cell lysis. CD7 is a transmembrane glycoprotein expressed by T-cells and natural killer (NK) cells and their precursors. It is expressed in the majority of lymphoblastic T-cell leukemias and lymphomas and in a subset of peripheral T-cell lymphomas. Removal of the endogenous CD7 antigen from the T-cell surface increases expansion and viability of the CAR-T cells and increases T-cell cytotoxic activity."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C3869774", "l": "Siderocytes.HPF", "d": []}]}
{"type": "biolink:Cell", "ic": "84.128890093485552", "identifiers": [{"i": "CL:1000320", "l": "large intestine goblet cell", "d": ["A goblet cell that is part of the epithelium of large intestine."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0229215", "l": "Horizontal cells of retina", "d": []}, {"i": "SNOMEDCT:29729006", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5557242", "l": "Allogeneic Anti-BCMA CAR T Cells P-BCMA-ALLO1", "d": []}, {"i": "NCIT:C181747", "l": "Allogeneic Anti-BCMA CAR T Cells P-BCMA-ALLO1", "d": ["An off-the-shelf (OTS) preparation composed of human allogeneic T-cells and containing primarily stem cell memory T-cells (Tscm) that are transfected by electroporation with a proprietary transposon-based DNA plasmid vector (PiggyBac; PB) encoding for an undisclosed drug selection gene encoding for a selectable marker to generate close to 100% CAR-based product, a caspase-based safety switch to reduce or eliminate the product in vivo if needed, and a B-cell maturation antigen (BCMA; tumor necrosis factor receptor superfamily member 17; TNFRSF17)-specific single domain variable heavy chain (VH) chimeric antigen receptor (CAR) (VCAR), with potential immunostimulating and antineoplastic activities. The CAR T-cells are also site specifically gene-edited with Cas-CLOVER (CC) to eliminate surface expression of both T-cell receptor (TCR) and beta-2 microglobulin (beta 2M) to decrease major histocompatibility complex (MHC) class I expression and further selected, by depletion of residual CD3-positive/TCR-positive cells, and expanded to yield Tscm enriched allogeneic transposed CAR-T cells. Upon administration, allogeneic anti-BCMA CAR T cells P-BCMA-ALLO1 specifically recognize and induce selective toxicity in BCMA-expressing tumor cells. BCMA, a tumor-specific antigen and a member of the tumor necrosis factor receptor superfamily (TNFRSF) that binds to both a proliferation-inducing ligand (APRIL; TNFSF13) and B-cell activating factor (BAFF; TNFSF13B), plays a key role in plasma cell survival. BCMA is found on the surfaces of plasma cells and is overexpressed on malignant plasma cells."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5161801", "l": "Cytoplasmic CD3 blasts | Blood | Cell markers", "d": []}]}
{"type": "biolink:Cell", "ic": "71.602448984170266", "identifiers": [{"i": "CL:0002491", "l": "auditory epithelial cell", "d": ["A specialized cell involved in auditory sensory perception."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0000421", "l": "coelomocyte", "d": ["A free floating cell, including amebocytes and eleocytes, in the coelom of certain animals, especially annelids."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157274", "l": "CD11c+CD25+ cells | Blood | Cell markers", "d": []}]}
{"type": "biolink:Cell", "ic": "81.247621244257502", "identifiers": [{"i": "CL:0005010", "l": "renal intercalated cell", "d": ["A cuboidal epithelial cell of the kidney that regulates acid/base balance."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4038446", "l": "Reticulocytes.hypochromic", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1440301", "l": "Cells.CD37", "d": []}]}
{"type": "biolink:Cell", "ic": "53.511376584254855", "identifiers": [{"i": "UMLS:C1515139", "l": "T-Lymphocyte and Natural Killer Cell", "d": []}, {"i": "NCIT:C39567", "l": "T-Lymphocyte and Natural Killer Cell", "d": ["Group of lymphocytes. A T-lymphocyte is a white blood cell differentiated in the thymus that possesses highly specific cell-surface antigen receptors. A natural killer cell resembles a T-lymphocyte, but it does not express markers of either T or B cell lineage. Its cytotoxic activity is not antibody dependent."]}]}
{"type": "biolink:Cell", "ic": "92.728541327098611", "identifiers": [{"i": "CL:0002017", "l": "Kit-negative, Ly-76 high orthochromatophilic erythroblasts", "d": ["An orthochromatophilic erythroblast that is ter119-high, CD71-low, and Kit-negative."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1514276", "l": "Postradiation Dysplastic Glandular Cell", "d": []}, {"i": "NCIT:C36805", "l": "Postradiation Dysplastic Glandular Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1511469", "l": "CY91", "d": []}, {"i": "NCIT:C20243", "l": "CY91", "d": ["Provider: CyThera, Inc., San Diego, CA. No information from provider. This cell line meets the criteria for the use of human embryonic stem cells by federally funded researchers."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4038491", "l": "Cells.diploid.G2 phase", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5216267", "l": "Metamyelocytes|NCnc|Pt|Bld", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5174861", "l": "Nonhematic cells | Cerebral spinal fluid | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1636199", "l": "Adipose derived adult stem cell", "d": []}, {"i": "SNOMEDCT:419288001", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0229662", "l": "Marrow fibrocyte", "d": []}, {"i": "SNOMEDCT:42901005", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1514760", "l": "Receptor Cell", "d": []}, {"i": "NCIT:C13156", "l": "Receptor Cell", "d": ["Specialized cells located in sense organs that respond to physical and chemical stimuli by sending information to the central nervous system."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4322823", "l": "CD24+ B lymphocyte", "d": []}]}
{"type": "biolink:Cell", "ic": "81.247621244257502", "identifiers": [{"i": "CL:0000718", "l": "compound eye cone cell", "d": ["A cell of an ommatidium that secretes lens materials."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5706365", "l": "Autologous Anti-ROR1 CAR T-cells LYL797", "d": []}, {"i": "NCIT:C187118", "l": "Autologous Anti-ROR1 CAR T-cells LYL797", "d": ["A preparation of genetically and epigenetically reprogrammed autologous T-lymphocytes transduced with a lentiviral vector to express a chimeric antigen receptor (CAR) targeting the receptor tyrosine kinase-like orphan receptor 1 (ROR1), with potential immunomodulatory and antineoplastic activities. After isolation, transduction, and expansion in culture, the autologous anti-ROR1 CAR T-cells LYL797 are reintroduced into the patient and are directed to tumor cells expressing ROR1, which may result in a selective toxicity against, and lysis of ROR1-expressing tumor cells. ROR1 is expressed during embryogenesis and upregulated in certain tumor types. High levels of ROR1 expression often correlate with poor prognosis. Due to the genetically and epigenetically modifications, LYL797 may overcome T-cell exhaustion and inability to self-renew. The T-cells are genetically modified to overexpress the protein c-Jun and thereby resist exhaustion and restore their anti-tumor activity. Also, the T-cells are reprogrammed to give them durable stemness and effector function."]}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "CL:0001016", "l": "immature CD1a-positive Langerhans cell", "d": ["Immature CD1a-positive Langerhans cell is a CD1a-positive Langerhans cell that is CD80-low, CD86-low, and MHCII-low."]}]}
{"type": "biolink:Cell", "ic": "72.683459462529498", "identifiers": [{"i": "UMLS:C0225369", "l": "Chondrocyte", "d": []}, {"i": "NCIT:C12557", "l": "Chondrocyte", "d": ["A cell arising from mesenchymal stem cells that produces and is surrounded by the extracellular matrix of cartilage."]}, {"i": "MESH:D019902", "l": "Chondrocytes", "d": []}, {"i": "SNOMEDCT:433180002", "d": []}, {"i": "SNOMEDCT:81272008", "d": []}]}
{"type": "biolink:Cell", "ic": "87.120474278337809", "identifiers": [{"i": "UMLS:C1711264", "l": "Polyhedral Melanocyte", "d": []}, {"i": "NCIT:C54079", "l": "Polyhedral Melanocyte", "d": []}]}
{"type": "biolink:Cell", "ic": "92.728541327098611", "identifiers": [{"i": "CL:1000239", "l": "anterior lateral line nerve glial cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157468", "l": "CD3+HLA-DR+ cells | Cerebral spinal fluid | Cell markers", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5555146", "l": "Autologous Anti-CD19 CAR-T Cells GC019F", "d": []}, {"i": "NCIT:C178588", "l": "Autologous Anti-CD19 CAR-T Cells GC019F", "d": ["A preparation of autologous T-lymphocytes that have been genetically modified to express a chimeric antigen receptor (CAR) specific for the tumor-associated antigen (TAA) CD19, with potential immunostimulating and antineoplastic activities. Upon administration, autologous anti-CD19 CAR-T cells GC019F target and bind to CD19-expressing tumor cells. This results in a cytotoxic T-lymphocyte (CTL) response against CD19-expressing tumor cells, the release of cytotoxic molecules and the induction of tumor cell lysis. CD19, cluster of differentiation 19, is a B-cell-specific cell surface antigen overexpressed in B-cell lineage tumors. The processing platform used, FasTCAR, shortens the manufacturing time to produce the CAR-T cells."]}]}
{"type": "biolink:Cell", "ic": "89.347505587204751", "identifiers": [{"i": "CL:0001071", "l": "group 3 innate lymphoid cell", "d": ["An innate lymphoid cell that constituitively expresses RORgt and is capable of expressing IL17A and/or IL-22."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1440140", "l": "Blasts.CD10", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1440332", "l": "Cells.CD53", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002309", "l": "corticotroph", "d": ["A basophil chromphil cell of the anterior pitiutary gland that produce adrenocorticotropic hormone, melanocyte-stimulating hormone and lipotropin. This cell type is irregular in shape and has short dendritic processes which are inserted among other neighboring cells;"]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C3282340", "l": "Cells, Cultured, Autologous", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5186228", "l": "Erythrocytes | Fetus | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5216218", "l": "Erythrocytes|NCnc|Pt|Plr fld", "d": []}]}
{"type": "biolink:Cell", "ic": "80.869303025598512", "identifiers": [{"i": "UMLS:C1516093", "l": "Atypical Epithelial Cell", "d": []}, {"i": "NCIT:C36914", "l": "Atypical Epithelial Cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0230518", "l": "Mitotic cell", "d": []}, {"i": "SNOMEDCT:75167008", "d": []}]}
{"type": "biolink:Cell", "ic": "77.944915021140389", "identifiers": [{"i": "CL:0002453", "l": "oligodendrocyte precursor cell", "d": ["A progenitor cell of the central nervous system that can differentiate into oligodendrocytes or type-2 astrocytes. This cell originates from multiple structures within the developing brain including the medial ganglion eminence and the lateral ganglionic eminence. These cells migrate throughout the central nervous system and persist into adulthood where they play an important role in remyelination of injured neurons."]}]}
{"type": "biolink:Cell", "ic": "67.387656307797414", "identifiers": [{"i": "UMLS:C1514089", "l": "Neoplastic Small Lymphocyte", "d": []}, {"i": "NCIT:C36998", "l": "Neoplastic Small Lymphocyte", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0000481", "l": "cholecystokin stimulating hormone secreting cell", "d": ["A peptide hormone secreting cell that secretes cholecystokin stimulating hormone."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C0017528", "l": "Giant Cells, Langhans", "d": []}, {"i": "NCIT:C12562", "l": "Langhans Cell", "d": []}, {"i": "MESH:D015744", "l": "Giant Cells, Langhans", "d": []}, {"i": "SNOMEDCT:30938003", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5203919", "l": "Autologous iC9-GD2CAR-CD28-CD3zeta-IL-15-expressing T-lymphocytes", "d": []}, {"i": "NCIT:C158732", "l": "Autologous iC9-GD2CAR-CD28-CD3zeta-IL-15-expressing T-lymphocytes", "d": ["A preparation of autologous T-lymphocytes that have been transduced with the retroviral vector SFG, a Moloney murine leukemia (Mo-MuLV) virus-based vector, expressing both an extracellular domain consisting of interleukin 15 (IL-15) and a GD2-specific chimeric antigen receptor (CAR) derived from the monoclonal antibody 14G2a, linked to the CD28 and CD3zeta (TCRzeta; CD247) costimulatory signaling domains and containing the suicide gene, inducible caspase 9 (iCasp9 or iC9), with potential immunomodulating and antineoplastic activities. Upon administration, the autologous iC9-GD2CAR-CD28-CD3zeta-IL-15-expressing T-lymphocytes recognize, bind to and induce selective cytotoxicity in GD2-expressing tumor cells. IL-15 is a pro-survival cytokine that promotes T-cell persistence and potentiates the immune response against tumor cells. Incorporation of the costimulatory signaling domains increases T-cell function, expansion, and survival. The iCasp9 safety switch consists of a full-length caspase 9, including its caspase recruitment domain, linked to a human FK506 drug-binding domain with an F36V mutation (FKBP12-F36V). If the administered CAR T-cells lead to unacceptable side effects, the chemical homodimerizer AP1903, which binds to the FKBP12-F36V drug-binding domain, activates caspase 9 and results in apoptosis of the administered CAR T-cells, can be administered. GD2, a disialoganglioside and tumor-associated antigen (TAA), is overexpressed on the surface of neuroblastoma cells and other neuroectoderm-derived neoplasms and is minimally expressed on normal, healthy cells."]}]}
{"type": "biolink:Cell", "ic": "74.107231545810777", "identifiers": [{"i": "CL:0000771", "l": "eosinophil", "d": ["Any of the immature or mature forms of a granular leukocyte with a nucleus that usually has two lobes connected by one or more slender threads of chromatin, and cytoplasm containing coarse, round granules that are uniform in size and which can be stained by the dye eosin. Eosinophils are CD9-positive, CD191-positive, and CD193-positive."]}]}
{"type": "biolink:Cell", "ic": "84.75972595860604", "identifiers": [{"i": "CL:0000802", "l": "CD8-alpha alpha positive, gamma-delta intraepithelial T cell", "d": ["A gamma-delta intraepithelial T cell that has the phenotype CD8-alpha alpha-positive."]}]}
{"type": "biolink:Cell", "ic": "92.728541327098611", "identifiers": [{"i": "CL:2000037", "l": "posterior lateral line neuromast hair cell", "d": ["Any neuromast hair cell that is part of a posterior lateral line."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:4030025", "l": "renal cortical fibroblast", "d": ["A fibroblast that is located in the renal cortical interstitium."]}]}
{"type": "biolink:Cell", "ic": "67.339867169364453", "identifiers": [{"i": "UMLS:C1518981", "l": "Perineural Cell", "d": []}, {"i": "NCIT:C41416", "l": "Perineural Cell", "d": ["A cell surrounding a neuron."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5177780", "l": "Polymorphonuclear cells | Pericardial fluid | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "ic": "71.975435936396124", "identifiers": [{"i": "UMLS:C1518229", "l": "Malignant Osteoblast", "d": []}, {"i": "NCIT:C36901", "l": "Malignant Osteoblast", "d": []}]}
{"type": "biolink:Cell", "ic": "90.82444074280258", "identifiers": [{"i": "CL:0002353", "l": "fetal liver hematopoietic progenitor cell", "d": ["A hematopoietic stem cell that resides in the fetal liver. In mice, this cell type is first observed at E10.5. This cell type is MHC-positive, HSA-positive, AA4.1-positive, CD45-positive, Sca-1 positive, CD150-positive, CD48-negative and CD244-negative."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5179521", "l": "Reticulocytes.high fluorescence/100 erythrocytes | Blood | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "ic": "71.975435936396124", "identifiers": [{"i": "CL:0000160", "l": "goblet cell", "d": ["A cell of the epithelial lining that produce and secrete mucins."]}]}
{"type": "biolink:Cell", "ic": "67.245311748130447", "identifiers": [{"i": "UMLS:C1517532", "l": "Germinal Center B-Lymphocyte", "d": []}, {"i": "NCIT:C38335", "l": "Germinal Center B-Lymphocyte", "d": ["A mature B-lymphocyte that is present in the geminal center of a lymphoid follicle."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5216215", "l": "Erythrocytes|NCnc|Pt|Gast fld", "d": []}]}
{"type": "biolink:Cell", "ic": "60.931845758659136", "identifiers": [{"i": "CL:0000838", "l": "lymphoid lineage restricted progenitor cell", "d": ["A progenitor cell restricted to the lymphoid lineage."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1513797", "l": "Mouse Myoepitheliocyte", "d": []}, {"i": "NCIT:C22697", "l": "Mouse Myoepitheliocyte", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2333949", "l": "Cholinergic Neurons", "d": []}, {"i": "MESH:D059329", "l": "Cholinergic Neurons", "d": []}]}
{"type": "biolink:Cell", "ic": "70.99638707280991", "identifiers": [{"i": "CL:3000004", "l": "peripheral sensory neuron", "d": ["Peripheral sensory neuron."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1516101", "l": "B-Prolymphocyte", "d": []}, {"i": "NCIT:C33926", "l": "B-Prolymphocyte", "d": ["A developmental form in the B-lymphocyte series, intermediate between the B-lymphoblast and the mature B-cell."]}]}
{"type": "biolink:Cell", "ic": "78.695011174409487", "identifiers": [{"i": "UMLS:C1882047", "l": "Neoplastic Epithelial Cell with Eosinophilic Cytoplasm", "d": []}, {"i": "NCIT:C61295", "l": "Neoplastic Epithelial Cell with Eosinophilic Cytoplasm", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5174104", "l": "Myelocytes/100 cells | Bone marrow | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5155168", "l": "Blasts | Cerebral spinal fluid | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1180237", "l": "Cuboidal endothelial cell of vascular tree", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C4725099", "l": "Autologous CD38-4SCAR-expressing T-cells 4SCAR38", "d": []}, {"i": "NCIT:C148523", "l": "Autologous CD38-4SCAR-expressing T-cells 4SCAR38", "d": ["A preparation of genetically modified autologous T-cells transduced with a replication incompetent, self-inactivating lentiviral vector expressing a fourth generation chimeric antigen receptor (4SCAR) consisting of an anti-CD38 single chain variable fragment (scFv) that is coupled to the costimulatory signaling domains CD28, CD137, CD27 and the zeta chain of the T-cell receptor (TCR), and is fused with the suicide gene inducible caspase 9 (iCasp9), with potential immunostimulating and antineoplastic activities. Upon intravenous administration, autologous CD38-4SCAR-expressing T-cells 4SCAR38 are directed to and induce selective toxicity in CD38-expressing tumor cells. iCasp9 consists of a human FK506 drug-binding domain with an F36V mutation (FKBP12-F36V) linked to human caspase 9. If the administered T-cells lead to unacceptable side effects, the chemical homodimerizer AP1903 can be administered. AP1903 binds to the drug binding FKBP12-F36V domain and induces activation of caspase 9, which results in the apoptosis of the administered T-cells and enhances safety of this agent. CD38, a type II transmembrane glycoprotein, is present on various immune cells and hematologic malignancies, and its expression has been correlated with poor prognosis. CD28, CD137 and CD27, T-cell surface-associated co-stimulatory molecules, are required for full T-cell activation and enhance both proliferation of T-cells and antitumor activity."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1181531", "l": "Type II cell of adrenal medulla", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0000415", "l": "diploid cell", "d": ["A cell whose nucleus has two haploid genomes."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5151350", "l": "Abnormal lymphocytes | Cerebral spinal fluid | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0001028", "l": "CD7-positive lymphoid progenitor cell", "d": ["CD7-positive lymphoid progenitor cell is a lymphoid progenitor cell that is CD34-positive, CD7-positive and is CD45RA-negative."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5163707", "l": "Erythrocytes | Amniotic fluid | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "ic": "83.023198044254755", "identifiers": [{"i": "CL:1000909", "l": "kidney loop of Henle epithelial cell", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:1000596", "l": "inner renal cortex cell", "d": []}]}
{"type": "biolink:Cell", "ic": "89.347505587204751", "identifiers": [{"i": "CL:0000579", "l": "border follicle cell", "d": ["A follicle cell that migrates from the anterior pole of the insect egg chamber to the anterior of the oocyte where they participate in the formation of the micropyle."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1179871", "l": "Myocyte of sinuatrial node", "d": []}]}
{"type": "biolink:Cell", "ic": "80.17194633000733", "identifiers": [{"i": "CL:0000595", "l": "enucleate erythrocyte", "d": ["An erythrocyte lacking a nucleus."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1182637", "l": "Secondary follicular cell of ovary", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C2985181", "l": "PSA-PAP/KLH-pulsed Autologous Dendritic Cell Vaccine", "d": []}, {"i": "NCIT:C92573", "l": "PSA-PAP/KLH-pulsed Autologous Dendritic Cell Vaccine", "d": ["A cell-based cancer vaccine composed of autologous dendritic cells (DCs) pulsed with the prostate-specific tumor associated antigens (TAAs) prostate specific antigen (PSA) and prostate acid phosphatase (PAP), and conjugated to the immunostimulant Keyhole limpet hemocyanin (KLH), with potential immunostimulatory and antineoplastic activities. Upon administration, prostate cancer antigen/KLH-pulsed autologous dendritic cell vaccine may stimulate the immune system to mount anti-tumoral cytotoxic T lymphocyte (CTL) and antibody responses against prostate cancer cells expressing PSA and PAP, which may result in prostate cancer cell lysis. KLH is an immunogenic carrier and serves as an immunostimulant to improve antigenic immune recognition and T-cell responses and can be used to evaluate vaccine efficacy."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5172548", "l": "Metamyelocytes | Cerebral spinal fluid | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "UMLS:C5707268", "l": "Malignant Thyroid Gland Follicular Signet Ring Cell", "d": []}, {"i": "NCIT:C187642", "l": "Malignant Thyroid Gland Follicular Signet Ring Cell", "d": ["A malignant thyroid gland follicular cell with cytoplasmic vacuole and eccentrically placed nucleus."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4322820", "l": "CD103+ T lymphocyte", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002464", "l": "SIRPa-negative adipose dendritic cell", "d": ["An adipose dendritic cell that is SIRPa-negative."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0882833", "l": "CD3+CD4+ cell", "d": []}, {"i": "SNOMEDCT:732279009", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0019021", "l": "endothelial cell of periportal hepatic sinusoid", "d": ["An endothelial cell found in the periportal region hepatic sinusoid, near the portal triad. The fenestrae of these cells are larger but fewer in number compared with those of endothelial cells near the centrilobular region of the hepatic sinusoid."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5186089", "l": "CD34 cells | Blood product unit | Cell markers", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:4033009", "l": "goblet cell of epithelium of lobar bronchus", "d": ["A(n) goblet cell that is part of a(n) epithelium of lobar bronchus."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:1000447", "l": "epithelial cell of stratum germinativum of esophagus", "d": ["A basal cell that is part of the epithelium of esophagus."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1517917", "l": "Hepatic stem cell", "d": []}, {"i": "NCIT:C12960", "l": "Liver Stem Cell", "d": ["An undifferentiated cell found in the liver."]}]}
{"type": "biolink:Cell", "ic": "83.552982069901191", "identifiers": [{"i": "UMLS:C0224522", "l": "Synoviocytes", "d": []}, {"i": "NCIT:C13059", "l": "Synovial Cell", "d": ["A fibroblast that lies between the cartilaginous fibers in the synovial membrane of joints."]}, {"i": "MESH:D000070918", "l": "Synoviocytes", "d": []}, {"i": "SNOMEDCT:76323008", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5173434", "l": "Monocytes | Fetus | Blood | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2324490", "l": "Set of B4 serotoninergic cells", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C4725853", "l": "AMG-119", "d": []}, {"i": "NCIT:C150586", "l": "CAR T-Cells AMG 119", "d": ["A preparation of T-lymphocytes that are genetically engineered to express a chimeric antigen receptor (CAR) that targets an as of yet unidentified tumor-associated antigen (TAA), with potential immunomodulatory and antineoplastic activities. Upon administration of the CAR T-cells AMG 119, the T-cells target, bind to and induce selective cytotoxicity in tumor cells expressing the TAA."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2350827", "l": "Ciliary Photoreceptor Cells", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157318", "l": "CD15 blasts | Bone marrow | Cell markers", "d": []}]}
{"type": "biolink:Cell", "ic": "66.70470389845471", "identifiers": [{"i": "UMLS:C1518272", "l": "Neuroectodermal Cell", "d": []}, {"i": "NCIT:C42050", "l": "Neuroectodermal Cell", "d": ["An embryonic cell on the dorsal surface of the early vertebrate embryo that gives rise to the cells of the nervous system"]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:4033036", "l": "OFFx cell", "d": ["An OFF bipolar cell that is fovea-specific and expresses FEZF1, NXPH1 and NXPH2."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0682699", "l": "neuron type by location", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4510908", "l": "Blast cell positive for CD135 antigen", "d": []}, {"i": "SNOMEDCT:724253008", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1182459", "l": "Differentiated muscle cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2339528", "l": "Retinal astrocyte", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1519129", "l": "SBIL-2 Transduced Autologous Tumor-Infiltrating Lymphocyte", "d": []}, {"i": "NCIT:C38118", "l": "SBIL-2 Transduced Autologous Tumor-Infiltrating Lymphocyte", "d": ["A population of tumor-infiltrating lymphocytes (TILs) harvested from a patient and transduced with a retroviral vector encoding the gene for interleukin-2 (IL-2).  TILs require IL-2 to sustain them when they are transferred back to the patient.  By inserting the IL-2 gene into TILs in vitro so that TILs express IL-2 continuously it is possible to provide TIL-sustaining IL-2 in vivo specifically at the site of lymphocyte infiltration, thereby avoiding the toxicity associated with the systemic administration of IL-2. (NCI04)"]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002282", "l": "type TG enteroendocrine cell", "d": ["An enteroendocrine cell which produces a gastrin- and cholecystokinin-like peptide. The apical microvilli-rich plasma membrane is in open contact with the small intestine mucosa. This cell type is devoid of gastrin-17 but contains other fragments of the gastrin polypeptide."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0333838", "l": "Gaucher-like cell", "d": []}, {"i": "SNOMEDCT:59870003", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5418038", "l": "Allogeneic Anti-CD19 Universal CAR-T Cells CTA101", "d": []}, {"i": "NCIT:C173959", "l": "Allogeneic Anti-CD19 Universal CAR-T Cells CTA101", "d": ["A preparation of allogeneic, off-the-shelf (OTS), universal, gene-edited T-lymphocytes expressing a chimeric antigen receptor (CAR) targeting the tumor-associated antigen (TAA) CD19, with potential immunomodulating and antineoplastic activities. Upon administration, allogeneic anti-CD19 universal CAR-T cells CTA101 specifically target and bind to CD19-expressing tumor cells, thereby selectively lysing CD19-expressing tumor cells. CD19 antigen is a B-cell specific cell surface antigen overexpressed in B-cell lineage malignancies. CTA101 is genetically engineered to prevent graft-versus-host disease (GvHD) by the donor T-cells. OTS CAR-T cells require reduced production times when compared to autologous CAR-T cells."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5216189", "l": "Basophils.immature|NCnc|Pt|Bld", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C0815004", "l": "Neural Crest Cells", "d": []}, {"i": "NCIT:C33937", "l": "Neural Crest Cell", "d": ["An embryonic cell that separates from the neural plate during formation of the neural tube and migrates to give several different lineages of adult cells: the spinal and autonomic ganglia, the glial cells of the peripheral nervous system, and nonneuronal cells, such as chromaffin cells, melanocytes and some haemopoietic cells."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0000753", "l": "type 1 cone bipolar cell (sensu Mus)", "d": ["An OFF-bipolar neuron found in the retina and having connections with cone photoreceptors cells and neurons in the outer half of the inner plexiform layer. The cell body of these cells is in the middle of the inner plexiform layer. The dendritic tree is stout and the axon terminates in sublamina 1. The axonal terminal is wide and has only a few varicosities."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C3900005", "l": "Autologous Anti-HPV-16 E6 T-cell Receptor Gene-engineered Peripheral Blood Lymphocytes", "d": []}, {"i": "NCIT:C118850", "l": "Autologous Anti-HPV-16 E6 T-cell Receptor Gene-engineered Peripheral Blood Lymphocytes", "d": ["Human autologous peripheral blood lymphocytes (PBLs) transduced with a retroviral vector encoding a T cell receptor (TCR) that is specifically directed against the viral oncoprotein human papillomavirus type 16 (HPV-16) E6, with potential antineoplastic activity. Upon isolation, transduction, expansion ex vivo, and reintroduction into the patient, the autologous anti-HPV-16 E6 TCR gene-engineered PBLs bind to HPV-16 E6-expressing tumor cells. This may result in a specific cytotoxic T-lymphocyte (CTL)-mediated killing of HPV-16 E6-positive cancer cells. HPV-16 E6, a cell surface glycoprotein, is overexpressed by a variety of HPV-associated cancers and is absent from healthy human tissues."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5426962", "l": "Erythrocytes | Lower respiratory specimen | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "ic": "68.594400196502249", "identifiers": [{"i": "CL:0000817", "l": "precursor B cell", "d": ["A precursor B cell is a B cell with the phenotype CD10-positive."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C3178783", "l": "Serotonergic Neurons", "d": []}, {"i": "MESH:D059326", "l": "Serotonergic Neurons", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0009052", "l": "smooth muscle cell of anorectum", "d": ["A smooth muscle cell that is located in the anorectum."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0545586", "l": "Blood medium lymphocyte", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0677646", "l": "crypt cell", "d": []}]}
{"type": "biolink:Cell", "ic": "71.975435936396124", "identifiers": [{"i": "UMLS:C1706715", "l": "Adenohypophysial Cell", "d": []}, {"i": "NCIT:C45920", "l": "Adenohypophysial Cell", "d": ["One of five types of secreting cells (somatotrophs, lactotrophs, corticotrophs, thyrotrophs, and gonadotrophs) found in the anterior lobe of the pituitary gland."]}]}
{"type": "biolink:Cell", "ic": "84.75972595860604", "identifiers": [{"i": "CL:0003001", "l": "bistratified retinal ganglion cell", "d": ["A retinal ganglion cell that has dendrites stratified in two layers of the inner-plexiform layer."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C0225699", "l": "Type-I Pneumocytes", "d": []}, {"i": "NCIT:C13144", "l": "Alveolar Cell Type I", "d": ["A squamous cell that forms the inner lining of the alveoli and is distinguished by its greatly attenuated cytoplasm and paucity of organelles."]}, {"i": "SNOMEDCT:34826000", "d": []}]}
{"type": "biolink:Cell", "ic": "76.857431420584163", "identifiers": [{"i": "UMLS:C1513993", "l": "Neoplastic Keratinocyte", "d": []}, {"i": "NCIT:C36749", "l": "Neoplastic Keratinocyte", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0009015", "l": "Peyer's patch follicular dendritic cell", "d": ["A follicular dendritic cell located in the Peyer's patch. These cells from a meshwork in which Peyer's patch B cells reside."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:4033032", "l": "diffuse bipolar 6 cell", "d": ["An ON diffuse bipolar cell that has a large dendritic field and large axon terminals, which show little or no overlap. This cell predominantly connects to narrow thorny ganglion cells."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0312739", "l": "Granular null cell", "d": []}, {"i": "SNOMEDCT:67124000", "d": []}]}
{"type": "biolink:Cell", "ic": "92.728541327098611", "identifiers": [{"i": "UMLS:C1522109", "l": "Leukocyte - Lymphocyte - B-Lymphocyte (MMHCC)", "d": []}, {"i": "NCIT:C22576", "l": "Mouse B-Lymphocyte", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002550", "l": "fibroblast of the conjunctiva", "d": ["A fibroblast that is part of the conjuctiva of the eye."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0333737", "l": "Muciphage", "d": []}, {"i": "SNOMEDCT:57068003", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0000478", "l": "oxytocin stimulating hormone secreting cell", "d": ["A peptide hormone secreting cell that secretes oxytocin stimulating hormone"]}]}
{"type": "biolink:Cell", "ic": "69.999780418226806", "identifiers": [{"i": "UMLS:C1514008", "l": "Neoplastic Large T-Lymphocyte", "d": []}, {"i": "NCIT:C37016", "l": "Neoplastic Large T-Lymphocyte", "d": []}]}
{"type": "biolink:Cell", "ic": "84.75972595860604", "identifiers": [{"i": "UMLS:C1708898", "l": "Malignant Parathyroid Gland Cell", "d": []}, {"i": "NCIT:C48266", "l": "Malignant Parathyroid Gland Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "81.648881485605159", "identifiers": [{"i": "CL:0000546", "l": "T-helper 2 cell", "d": ["A CD4-positive, alpha-beta T cell that has the phenotype GATA-3-positive, CXCR3-negative, CCR6-negative, and is capable of producing interleukin-4."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:1000366", "l": "transitional myocyte of middle internodal tract", "d": ["A transitional myocyte that is part of the middle internodal tract."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5706372", "l": "Anti-BCMA/Anti-GPRC5D CAR-T Cells OriC321", "d": []}, {"i": "NCIT:C187125", "l": "Anti-BCMA/Anti-GPRC5D CAR-T Cells OriC321", "d": ["A preparation of T-lymphocytes engineered to express chimeric antigen receptor(s) (CAR) targeting the human tumor-associated antigens (TAAs) B-cell maturation antigen (BCMA; tumor necrosis factor receptor superfamily member 17; TNFRSF17) and G-protein coupled receptor family C group 5 member D (GPRC5D) and fused to as of yet not fully elucidated co-stimulatory domains, with potential immunostimulating and antineoplastic activities. Upon administration, the anti-BCMA/anti-GPRC5D CAR-T cells OriC321 specifically and simultaneously target and bind to tumor cells expressing BCMA and/or GPRC5D. This induces selective toxicity in tumor cells that express BCMA and/or GPRC5D. BCMA, a receptor for both a proliferation-inducing ligand (APRIL) and B-cell activating factor (BAFF), is a member of the tumor necrosis factor receptor superfamily (TNFRSF). BCMA is found on the surfaces of plasma cells, is overexpressed on malignant plasma cells and plays a key role in plasma cell proliferation and survival. GPRC5D is overexpressed in certain malignancies, such as multiple myeloma, while minimally expressed in normal, healthy cells. It plays a key role in tumor cell proliferation."]}]}
{"type": "biolink:Cell", "ic": "39.639890282049777", "identifiers": [{"i": "CL:0000521", "l": "fungal cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5216256", "l": "Lymphoma cells|NCnc|Pt|Bld", "d": []}]}
{"type": "biolink:Cell", "ic": "69.25985915845861", "identifiers": [{"i": "CL:0000625", "l": "CD8-positive, alpha-beta T cell", "d": ["A T cell expressing an alpha-beta T cell receptor and the CD8 coreceptor."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5382750", "l": "CD107a+b expressing HLA-B8 Cytomegalovirus specific CD8 cells | Blood | Cell markers", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0427567", "l": "Microthrombocyte", "d": []}, {"i": "SNOMEDCT:250316002", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1831954", "l": "Allogeneic Epstein-Barr Virus-Specific Cytotoxic T-Lymphocytes", "d": []}, {"i": "NCIT:C62769", "l": "Allogeneic Epstein-Barr Virus-Specific Cytotoxic T-Lymphocytes", "d": ["A preparation of allogeneic Epstein-Barr virus (EBV) specific cytotoxic T-lymphocytes (CTL) with potential antineoplastic activity. Upon administration, the allogeneic EBV-specific CTLs are either harvested from a donor with an EBV-positive tumor or are donor CTLs activated against EBV-specific antigens ex vivo. Administration into a patient exerts a CTL response against EBV-positive tumor cells or EBV-infected cells. This results in cell lysis and inhibition of cancer cell proliferation. EBV, a ubiquitous human herpes virus, is associated with various malignancies, including nasopharyngeal carcinoma, Hodgkin disease, non-Hodgkin lymphoma, and other lymphomas."]}]}
{"type": "biolink:Cell", "ic": "92.728541327098611", "identifiers": [{"i": "CL:0000005", "l": "fibroblast neural crest derived", "d": ["Any fibroblast that is deriived from the neural crest."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0000743", "l": "hypertrophic chondrocyte", "d": ["Chondrocyte that is terminally differentiated, produces type X collagen, is large in size, and often associated with the replacement of cartilage by bone (endochondral ossification)."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1267862", "l": "Lymphocyte positive for CD10 antigen", "d": []}, {"i": "SNOMEDCT:116848002", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157295", "l": "CD13 blasts | Blood | Cell markers", "d": []}]}
{"type": "biolink:Cell", "ic": "79.849015605436421", "identifiers": [{"i": "CL:0000121", "l": "Purkinje cell", "d": ["The output neuron of the cerebellar cortex."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0000993", "l": "mature CD11c-low plasmacytoid dendritic cell", "d": ["Mature CD11c-low plasmacytoid dendritic cell is a CD11c-low plasmacytoid dendritic cell that is CD83-high and is CD80-positive, CD86-positive, and MHCII-positive."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5181363", "l": "Spermatozoa Motile | Semen | Fertility testing", "d": []}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "CL:0000862", "l": "suppressor macrophage", "d": ["A macrophage that suppresses immune responses."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:1000356", "l": "microfold cell of epithelium proper of duodenum", "d": ["A M cell that is part of the epithelium proper of duodenum."]}]}
{"type": "biolink:Cell", "ic": "74.659114980698789", "identifiers": [{"i": "UMLS:C1711387", "l": "Neoplastic Adrenal Cortical Cell", "d": []}, {"i": "NCIT:C48361", "l": "Neoplastic Adrenal Cortical Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "83.552982069901191", "identifiers": [{"i": "UMLS:C1709191", "l": "Neoplastic Parathyroid Gland Clear Cell", "d": []}, {"i": "NCIT:C48279", "l": "Neoplastic Parathyroid Gland Clear Cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2326430", "l": "Bronchial goblet cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5177453", "l": "Plasma cells | Blood | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "ic": "78.96520244130248", "identifiers": [{"i": "UMLS:C1514107", "l": "Neoplastic T-Immunoblast", "d": []}, {"i": "NCIT:C37012", "l": "Neoplastic T-Immunoblast", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5239343", "l": "Autologous Anti-B7-H3 CAR Retroviral Vector-transduced T Cells", "d": []}, {"i": "NCIT:C169051", "l": "Autologous Anti-B7-H3 CAR Retroviral Vector-transduced T Cells", "d": ["A preparation of autologous T-lymphocytes that have been transduced with a retroviral vector expressing a chimeric antigen receptor (CAR) targeting the immunoregulatory protein B7-homologue 3 (B7-H3, CD276) and containing, as of yet undisclosed co-stimulatory signaling domains, with potential immunostimulating and antineoplastic activities. Upon infusion back into the patient, autologous anti-B7-H3 CAR retroviral vector-transduced T cells target and bind to B7-H3-expressing tumor cells, thereby inducing selective toxicity in B7-H3-expressing tumor cells. B7-H3, a type I transmembrane protein and a member of the B7 co-stimulatory protein superfamily, is overexpressed on certain tumor cell types and on various immune cells. It is a negative regulator of the T-cell activation and its overexpression plays a key role in tumor cell invasion and metastasis."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C3176908", "l": "Cells.cytoplasmic Ig", "d": []}]}
{"type": "biolink:Cell", "ic": "72.170119586754993", "identifiers": [{"i": "UMLS:C1512992", "l": "Marginal Zone B-Lymphocyte", "d": []}, {"i": "NCIT:C38729", "l": "Marginal Zone B-Lymphocyte", "d": ["A lymphocyte found in the marginal zones of lymphoid tissues. It has a naive B lymphoid lineage and plays an important role in the early phases of immune response with its ability to rapidly differentiate into an antibody secreting cell. These cells can directly activate T cells, interact with other antigen presenting cells, transporting and concentrating antigen during the course of T-dependent and T-independent immune responses."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002599", "l": "smooth muscle cell of the esophagus", "d": ["A smooth muscle cell of the esophagus."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0225466", "l": "Structure of anterior cells of ethmoid sinus", "d": []}, {"i": "SNOMEDCT:26357003", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0333771", "l": "Coil/whorled fibers", "d": []}, {"i": "SNOMEDCT:487002", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1956422", "l": "Cancer Stem Cells", "d": []}, {"i": "NCIT:C68706", "l": "Cancer Stem Cell", "d": ["A malignant cell which may derive from mutations in normal stem cells. Cancer stem cells proliferate and give rise to other malignant cells. They may be present in very small numbers in the tumor and may not be present in all tumors. Many investigators believe that cancer stem cells cause relapse of the tumor and that novel cancer therapies should specifically target those cells."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4322812", "l": "CD43+ T lymphocyte", "d": []}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "CL:0008005", "l": "obliquely striated somatic muscle cell", "d": ["A somatic muscle cell that is oblquely striated.  Examples include the somatic muscles of nematodes."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5690233", "l": "Polymorphonuclear cells | Dialysis fluid peritoneal | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1181535", "l": "Chromaffin cell of paraaortic body", "d": []}]}
{"type": "biolink:Cell", "ic": "79.541110464886842", "identifiers": [{"i": "CL:0000840", "l": "immature conventional dendritic cell", "d": ["An immature cell of the conventional dendritic cell lineage, characterized by high levels of antigen uptake via endocytosis, macropinocytosis, and phagocytosis, and typically found resident in the tissues. Markers for this cell are CD80-low, CD86-low, and MHC-II-low."]}]}
{"type": "biolink:Cell", "ic": "65.702982456578013", "identifiers": [{"i": "CL:0000335", "l": "mesenchyme condensation cell", "d": ["A mesenchymal cell in embryonic development found in a contracting mass and that gives rise to osteoprogenitors."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:1000391", "l": "melanocyte of eyelid", "d": ["A melanocyte that is part of the eyelid."]}]}
{"type": "biolink:Cell", "ic": "73.721563224321088", "identifiers": [{"i": "UMLS:C2346938", "l": "Malignant Trophoblastic Cell", "d": []}, {"i": "NCIT:C68658", "l": "Malignant Trophoblastic Cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1280428", "l": "Entire delta Cell of islet", "d": []}, {"i": "SNOMEDCT:247952004", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2335910", "l": "Set of cholinergic cells of dorsal tegmental area [Ch6]", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5177629", "l": "Platelets reticulated | Blood | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C0227882", "l": "Secondary oocyte", "d": []}, {"i": "NCIT:C33523", "l": "Secondary Oocyte", "d": ["A female germ cell in which the first meiotic division is completed. The second meiotic division usually stops short of completion unless fertilization occurs."]}, {"i": "SNOMEDCT:46886002", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0376351", "l": "Photoreceptor Cells, Vertebrate", "d": []}, {"i": "MESH:D020419", "l": "Photoreceptor Cells, Vertebrate", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2340471", "l": "Late promyelocyte", "d": []}]}
{"type": "biolink:Cell", "ic": "92.728541327098611", "identifiers": [{"i": "CL:0002101", "l": "CD38-positive naive B cell", "d": ["A CD38-positive naive B cell is a mature B cell that has the phenotype CD38-positive, surface IgD-positive, surface IgM-positive, and CD27-negative, and that has not yet been activated by antigen in the periphery."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5154488", "l": "Basophils/100 cells | Bone marrow | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1517807", "l": "Leukemic Hematopoietic Stem Cell", "d": []}, {"i": "NCIT:C41069", "l": "Leukemic Hematopoietic Stem Cell", "d": ["A malignant hematopoietic cell which may derive from mutations in normal hematopoietic stem cells. Leukemic hematopoietic stem cells can initiate or sustain neoplastic hematopoietic diseases because they are able to both proliferate and give rise to other malignant cells."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5401599", "l": "Allogenic Pooled Olfactory Mucosa-derived Mesenchymal Stem Cells", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:2000077", "l": "skeletal muscle tissue of pectoralis major striated muscle cell", "d": ["Any striated muscle cell that is part of a skeletal muscle tissue of pectoralis major."]}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "CL:0000535", "l": "secondary neuron (sensu Teleostei)", "d": ["A neuron of teleosts that develops later than a primary neuron, typically during the larval stages."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157490", "l": "CD34 blasts | Blood | Cell markers", "d": []}]}
{"type": "biolink:Cell", "ic": "86.236661114203869", "identifiers": [{"i": "UMLS:C0242245", "l": "Dendritic Cells, Follicular", "d": []}, {"i": "NCIT:C12622", "l": "Follicular Dendritic Cell", "d": ["Antigen Presenting Cells (APCs) located in the follicles of secondary lymphoid organs.  These dendritic cells are unique because of their location, primarily in lymphoid follicles, and because of their function in retaining antigen molecules for extended periods of time and serving as APCs for B cells."]}, {"i": "MESH:D020566", "l": "Dendritic Cells, Follicular", "d": []}, {"i": "SNOMEDCT:56685008", "d": []}]}
{"type": "biolink:Cell", "ic": "43.00066299783748", "identifiers": [{"i": "UMLS:C1512100", "l": "Dysplastic Epithelial Cell", "d": []}, {"i": "NCIT:C36807", "l": "Dysplastic Epithelial Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "61.059660402022018", "identifiers": [{"i": "CL:0011012", "l": "neural crest cell", "d": ["A cell of the neural crest. Neural crest cells are multipotent. Premigratory neural crest cells are found at the neural plate boarder, some of which will undergo ectomesynchymal transition and delamination to form migratory neural crest cells."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1284809", "l": "Entire supporting cell of organ of Corti", "d": []}, {"i": "SNOMEDCT:362573009", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5417981", "l": "Autologous Anti-BCMA CD8+ CAR T-cells Descartes-11", "d": []}, {"i": "NCIT:C173434", "l": "Autologous Anti-BCMA CD8+ CAR T-cells Descartes-11", "d": ["A preparation of autologous CD8-positive T-lymphocytes that have been genetically modified to express a chimeric antigen receptor (CAR) specific for the tumor-associated antigen (TAA) human B-cell maturation antigen (BCMA; tumor necrosis factor receptor superfamily member 17; TNFRSF17), with potential immunostimulating and antineoplastic activities. Upon administration, autologous anti-BCMA CD8+ CAR T-cells Descartes-11 specifically recognize and induce selective toxicity in BCMA-expressing tumor cells. BCMA, a tumor-specific antigen and a receptor for both a proliferation-inducing ligand (APRIL) and B-cell activating factor (BAFF), is a member of the tumor necrosis factor receptor superfamily (TNFRSF) and plays a key role in plasma cell survival. BCMA is found on the surfaces of plasma cells and is overexpressed on malignant plasma cells."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1181293", "l": "Ecto-epithelial cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5216248", "l": "Lymphocytes.variant|NCnc|Pt|Body fld", "d": []}]}
{"type": "biolink:Cell", "ic": "66.24517279685756", "identifiers": [{"i": "CL:0002191", "l": "granulocytopoietic cell", "d": ["A cell involved in the formation of a granulocyte."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C4684971", "l": "Allogeneic Nicotinamide-expanded Natural Killer Cells", "d": []}, {"i": "NCIT:C143157", "l": "Allogeneic Nicotinamide-expanded Natural Killer Cells", "d": ["Allogeneic, nicotinamide (NAM)-expanded natural killer (NK) cells, with potential cytolytic and antineoplastic activities. Upon administration, the allogeneic NAM-expanded NK cells may lyse cancer cells. These cells also secrete pro-inflammatory cytokines, which further stimulate an anti-tumor immune response. Ex-vivo treatment with the vitamin B3 derivative NAM increases the in-vivo homing, retention and proliferation potential of the NK cells."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1514203", "l": "Polygonal or Elongated Mononuclear Mesenchymal Cell", "d": []}, {"i": "NCIT:C36932", "l": "Polygonal or Elongated Mononuclear Mesenchymal Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "75.58416670140862", "identifiers": [{"i": "UMLS:C5446930", "l": "Anti-BCMA-targeting CAR-T Cells", "d": []}, {"i": "NCIT:C176023", "l": "Anti-BCMA-targeting CAR-T Cells", "d": ["A preparation of CAR-T cells that targets BCMA."]}]}
{"type": "biolink:Cell", "ic": "90.82444074280258", "identifiers": [{"i": "CL:0002361", "l": "primitive erythroid progenitor", "d": ["A progenitor cell that is capable of forming colonies of primitive erythrocytes in the blood island of the yolk sac. First arrive at E7.5 in mouse and expresses CD41."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5175147", "l": "Nucleated cells | Bone marrow | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1507325", "l": "Cells.CD13+CD16+", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5666943", "l": "Autologous WT1-directed CRISPR/Cas9-engineered TCR-T Cells NTLA-5001", "d": []}, {"i": "NCIT:C185126", "l": "Autologous WT1-directed CRISPR/Cas9-engineered TCR-T Cells NTLA-5001", "d": ["A preparation of human autologous T-lymphocytes gene-edited with the clustered regularly interspaced short palindromic repeats (CRISPR)-Cas9 nuclease complex to disrupt expression of endogenous T-cell receptor (TCR) and modified to express a TCR specific for the tumor-associated antigen (TAA) Wilms tumor 1 (WT1) epitope, WT1 37-45, and human leukocyte antigen (HLA)-A*02:01, with potential immunostimulating and antineoplastic activities. Upon isolation, transduction, expansion ex vivo, and reintroduction into the patient, the autologous WT1-directed CRISPR/Cas9-engineered TCR-T cells NTLA-5001 recognize and bind to WT1-expressing tumor cells. This may result in a specific cytotoxic T-lymphocyte (CTL)-mediated killing of WT1-expressing tumor cells. WT1 protein, a zinc finger DNA-binding transcriptional regulator, is overexpressed in various leukemias and solid tumors, while expression in normal, healthy tissues is very limited; its expression is correlated with aggressiveness and poor prognosis. The removal of endogenous TCR reduces TCR competition for expression, increases the persistence and function of the expressed transgenic TCR, enhances resistance to T-cell exhaustion and increases T-cell activity."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0333804", "l": "Stomatocyte (cell)", "d": []}, {"i": "SNOMEDCT:10636005", "d": []}]}
{"type": "biolink:Cell", "ic": "83.552982069901191", "identifiers": [{"i": "UMLS:C1512566", "l": "Hypolobated Neutrophil", "d": []}, {"i": "NCIT:C37172", "l": "Hypolobated Neutrophil", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157310", "l": "CD14 cells | Blood | Cell markers", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002442", "l": "CD94-negative, Ly49CI-negative natural killer cell, mouse", "d": ["A NK1.1-positive T cell that is CD94-negative and Ly49Cl-negative."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157411", "l": "CD25 cells | XXX | Cell markers", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2952444", "l": "Mononuclear phagocyte", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:4033019", "l": "ON-blue cone bipolar cell", "d": ["An ON bipolar cell type with dendrites selectively contacting S-cones."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:4033049", "l": "taste receptor cell of tongue", "d": ["A taste receptor cell that is part of a taste bud of a tongue."]}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "CL:0002095", "l": "hilus cell of ovary", "d": ["A cell in the hilum of the ovary that produces androgens."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:4040000", "l": "glial restricted tripotential precursor cell", "d": ["A glial precursor cell that generates oligodendrocytes and type-1 and type-2 astrocytes. It has been shown in some mammals that this cell type may express A2B5, nestin, FGFR-1, FGFR-2, FGFR-3, PLP, and DM-20 antigens. Unlike oligodendrocyte precursor cell, it does not initially express PDGFR-alpha and can differentiate into both type-1 and type-2 astrocytes."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1182605", "l": "Ciliated columnar cell of tracheobronchial tree", "d": []}, {"i": "NCIT:C32317", "l": "Ciliated Bronchial Epithelial Cell", "d": ["A columnar-shaped cell found in the epithelium of the lobular bronchiole. Each cell contains 200-300 cilia 5-8 mm long. The cilia are part of the mucociliary system, which extends through the tracheobronchial tree and into the respiratory bronchioles. This system protects the respiratory surface from dirt and airborne infection and represents the principal mechanism of defense in the respiratory tract. The cilia beat in unison (about 1,000 strokes per minute) and in a wave-like fashion, thereby propelling mucus and entrapped foreign material toward the oropharynx for expectoration or swallowing."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002451", "l": "mammary stem cell", "d": ["A multi-fate stem cell that is the source of cells for growth of the mammary gland during puberty and gestation. This cell type gives rise to both the luminal and myoepithelial cell types of the gland, and have been shown to have the ability to regenerate the entire organ in mice. This cell type also plays an important role in carcinogenesis of the breast. This cell type is Lin-, CD24-positive, CD29-hi."]}]}
{"type": "biolink:Cell", "ic": "90.82444074280258", "identifiers": [{"i": "CL:0002382", "l": "multinucleate conidium", "d": ["A conidium that has more than one nucleus."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5186830", "l": "Myelocytes | Fetus | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002515", "l": "interrenal norepinephrine type cell", "d": ["An interrenal chromaffin cell found in teleosts that contain heterogeneous vesicles with electron-dense granules located asymmetrically within the vesicular membrane."]}]}
{"type": "biolink:Cell", "ic": "56.959548363731535", "identifiers": [{"i": "CL:0000515", "l": "skeletal muscle myoblast", "d": ["A myoblast that differentiates into skeletal muscle fibers."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:1000376", "l": "Purkinje myocyte of interventricular septum", "d": ["A Purkinje myocyte that is part of the interventricular septum."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002125", "l": "CD27-negative gamma-delta T cell", "d": ["A circulating gamma-delta T cell that expresses RORgamma(t), is CD27-negative and is capable of IL-17 secretion."]}]}
{"type": "biolink:Cell", "ic": "78.185623981295834", "identifiers": [{"i": "UMLS:C1519460", "l": "Neoplastic Spindle-Shaped Myofibroblast", "d": []}, {"i": "NCIT:C36957", "l": "Neoplastic Spindle-Shaped Myofibroblast", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1956120", "l": "Dermal Dendritic Cells", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157539", "l": "CD4+CD25+CD45RO+CD127Low+ cells | Blood | Cell markers", "d": []}]}
{"type": "biolink:Cell", "ic": "79.541110464886842", "identifiers": [{"i": "CL:0010007", "l": "His-Purkinje system cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1440296", "l": "Cells.CD33+CD44+", "d": []}]}
{"type": "biolink:Cell", "ic": "92.728541327098611", "identifiers": [{"i": "CL:0002516", "l": "interrenal chromaffin cell", "d": ["A chromaffin cell interspersed among the interrenal epithelial layer of the anterior kidney of teloest fish."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1545484", "l": "Non-squamous epithelial cell", "d": []}, {"i": "SNOMEDCT:725264003", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5216222", "l": "Hairy cells|NCnc|Pt|Bld", "d": []}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "CL:0002678", "l": "memory regulatory T cell", "d": ["A CD4-positive, CD25-positive alpha-beta regulatory T cell that has encountered antigen."]}]}
{"type": "biolink:Cell", "ic": "65.968527344256771", "identifiers": [{"i": "CL:4023070", "l": "caudal ganglionic eminence derived GABAergic cortical interneuron", "d": ["A GABAergic cortical interneuron that develops from the caudal ganglionic eminence and has migrated to the cerebral cortex."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5158327", "l": "Cells.CD3+CD4+CD8+ (Double positive) | Blood | Cell markers", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1979779", "l": "Other cells", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:4023024", "l": "neurogliaform lamp5 GABAergic cortical interneuron (Mmus)", "d": ["A lamp5 GABAergic cortical interneuron with layer-adapting morphology. NGC lamp5 cells have a small round soma, short dendrites, and a wide dense axonal arbor that tends to establish a dense axonal mesh with high connection probability both to themselves and L2 pyramidal cells. NGC lamp5 cells have unique synaptic properties that distinguish them from other GABAergic interneurons, including the release of GABA to the extracellular space via volume transmission, and the ability to produce GABA-B responses in connected postsynaptic targets."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0581780", "l": "Stem cell colony-forming unit", "d": []}, {"i": "SNOMEDCT:259731003", "d": []}]}
{"type": "biolink:Cell", "ic": "79.849015605436421", "identifiers": [{"i": "CL:0000010", "l": "cultured cell", "d": ["A cell in vitro that is or has been maintained or propagated as part of a cell culture."]}]}
{"type": "biolink:Cell", "ic": "80.511444690059548", "identifiers": [{"i": "CL:0002436", "l": "mature CD4 single-positive thymocyte", "d": ["A mature CD4-positive, CD8-negative alpha-beta T cell found in the thymus that is CD24-low and has high expression of the T cell receptor."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5216212", "l": "Erythrocytes|NCnc|Pt|CSF", "d": []}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "CL:2000000", "l": "epidermal melanocyte", "d": ["Any melanocyte that is part of a epidermis."]}]}
{"type": "biolink:Cell", "ic": "67.631918968397358", "identifiers": [{"i": "CL:0000035", "l": "single fate stem cell", "d": ["A stem cell that self-renews as well as give rise to a single mature cell type."]}]}
{"type": "biolink:Cell", "ic": "75.923665061460838", "identifiers": [{"i": "CL:0002072", "l": "nodal myocyte", "d": ["A specialized cardiac myocyte in the sinoatrial and atrioventricular nodes. The cell is slender and fusiform confined to the nodal center, circumferentially arranged around the nodal artery."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0242598", "l": "LLC-PK1 Cells", "d": []}, {"i": "MESH:D018374", "l": "LLC-PK1 Cells", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C3273372", "l": "CD4 Positive Naive T-Lymphocyte", "d": []}, {"i": "NCIT:C97350", "l": "CD4 Positive Naive T-Lymphocyte", "d": ["A T lymphocyte that has differentiated in the bone marrow, undergone central selection in the thymus, but has not encountered its cognate antigen in the peripheral circulation. These cells can be identified by presence of both the CD4 and CD45RA molecules on their surface."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1440389", "l": "Cells.HLA-DR+", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5203880", "l": "Autologous Anti-GD2CAR-CD28-CD3zeta-IL-15-expressing Natural Killer T-cells", "d": []}, {"i": "NCIT:C158682", "l": "Autologous Anti-GD2CAR-CD28-CD3zeta-IL-15-expressing Natural Killer T-cells", "d": ["A preparation of autologous natural killer T-lymphocytes (NKTs) that have been transduced with a retroviral vector to express both an extracellular domain consisting of interleukin 15 (IL-15) and a chimeric antigen receptor (CAR) specific for the human tumor associated antigen (TAA) GD2, linked to the CD28 and CD3zeta (TCRzeta; CD247) costimulatory signaling domains, with potential antineoplastic activity. Upon intravenous administration, autologous anti-GD2CAR-CD28-CD3zeta-IL-15-expressing NKTs target, bind to, and induce selective toxicity in GD2-expressing tumor cells. IL-15 is a pro-survival cytokine that promotes T-cell persistence and potentiates the immune response against tumor cells. Incorporation of the costimulatory signaling domains increases T-cell function, expansion, and survival. The CD28 costimulatory molecule signaling domain enhances activation and signaling after recognition of GD2. Additionally, inclusion of the CD28 signaling domain may increase proliferation of T-cells and antitumor activity compared to the inclusion of the CD3zeta chain alone. GD2, a disialoganglioside and tumor-associated antigen (TAA), is overexpressed in a variety of tumor cell types."]}]}
{"type": "biolink:Cell", "ic": "82.076046914303362", "identifiers": [{"i": "CL:1000050", "l": "lateral line nerve glial cell", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:1000362", "l": "transitional myocyte of interventricular septum", "d": ["A transitional myocyte that is part of the interventricular septum."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0009075", "l": "myo-medullary thymic epithelial cell", "d": ["A thymic medullary epithelial cell that expresses muscle-specific biomarkers."]}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "CL:0002677", "l": "naive regulatory T cell", "d": ["A regulatory T cell that has not encountered antigen."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2330221", "l": "Goblet cell of epithelium of intestinal villus", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C0003649", "l": "APUD Cells", "d": []}, {"i": "NCIT:C12655", "l": "APUD Cell", "d": ["An endocrine cell that has the capabilities of amine precursor uptake and decarboxylation, and low molecular weight polypeptide hormone secretion."]}, {"i": "MESH:D001078", "l": "APUD Cells", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2717773", "l": "Gametophytes", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5173061", "l": "Microcytes | Urine | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1257857", "l": "COS-1 Cells", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5555831", "l": "TBX-4000-treated Hematopoietic Stem Cells TBX-2400", "d": []}, {"i": "NCIT:C179636", "l": "TBX-4000-treated Hematopoietic Stem Cells TBX-2400", "d": ["An allogeneic cell preparation in which donor-derived hematopoietic stem cells (HSCs) are treated ex vivo with TBX-4000, a recombinant TAT-MYC fusion protein, with potential immunoreconstitutive activity. Upon administration, the TBX-4000-treated HSCs TBX-2400 may enhance the engraftment of the bone marrow upon allogeneic hematopoietic stem cells transplant (HSCT). The TBX-4000 recombinant fusion protein consists of the N-terminal 9 amino acid segment of the HIV TAT protein transduction domain (PTD) fused to the MYC protein. TBX-4000 TAT-MYC rapidly localizes to the nucleus and transiently provides signals to drive proliferation and survival of the HSCs."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002259", "l": "neuroepithelial stem cell", "d": ["The stem cell from which glial precursor cell arises from."]}]}
{"type": "biolink:Cell", "ic": "64.6720795298599", "identifiers": [{"i": "CL:0000362", "l": "epidermal cell", "d": ["An epithelial cell of the integument (the outer layer of an organism)."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157429", "l": "CD3+CD16+CD56+ cells | Bone marrow | Cell markers", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:1000716", "l": "kidney outer medulla collecting duct principal cell", "d": ["Principal cell that is part of some outer medullary collecting duct. It is known in some mammalian species that this cell may express the epithelial sodium channel (ENaC)."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2336931", "l": "Goblet cell of epithelium proper of large intestine", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4072756", "l": "Cells.RARA gene rearrangements", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2350151", "l": "Normoblasts", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4697022", "l": "Cells.CD27+CD45RO+CD62L+CCR7+", "d": []}]}
{"type": "biolink:Cell", "ic": "86.236661114203869", "identifiers": [{"i": "UMLS:C1882045", "l": "Neoplastic Columnar Epithelial Cell", "d": []}, {"i": "NCIT:C62202", "l": "Neoplastic Columnar Epithelial Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "65.236426385580998", "identifiers": [{"i": "UMLS:C0225340", "l": "Transitional Epithelial Cells", "d": []}, {"i": "NCIT:C12866", "l": "Transitional Cell", "d": []}, {"i": "SNOMEDCT:3028004", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0004234", "l": "diffuse multistratified amacrine cell", "d": ["An amacrine cell with a medium dendritic field and post-synaptic terminals in S2, and in S3-S4."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1183428", "l": "Solocyte", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1254573", "l": "Mature Erythrocytes", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0000528", "l": "nitrergic neuron", "d": ["A nerve cell where transmission is mediated by nitric oxide."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4072755", "l": "Cells.TRA+TRD gene rearrangements", "d": []}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "CL:0000892", "l": "smooth muscle cell derived foam cell", "d": ["A type of foam cell derived from a smooth muscle cell containing lipids in small vacuoles and typically seen in atherolosclerotic lesions, as well as other conditions."]}]}
{"type": "biolink:Cell", "ic": "78.185623981295834", "identifiers": [{"i": "CL:0000792", "l": "CD4-positive, CD25-positive, alpha-beta regulatory T cell", "d": ["A CD4-positive, CD25-positive, alpha-beta T cell that regulates overall immune responses as well as the responses of other T cell subsets through direct cell-cell contact and cytokine release."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1179114", "l": "Basal cell of olfactory epithelium", "d": []}, {"i": "NCIT:C13153", "l": "Olfactory Basal Cell", "d": ["A cell found in the pseudostratified epithelium lining the olfactory region of the nasal cavity. It gives rise to olfactory receptor cells and sustentacular cells."]}]}
{"type": "biolink:Cell", "ic": "76.46797986554256", "identifiers": [{"i": "UMLS:C1711388", "l": "Neoplastic Dendritic Cell", "d": []}, {"i": "NCIT:C43271", "l": "Neoplastic Dendritic Cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C3176807", "l": "Blasts.cytoplasmic CD3", "d": []}]}
{"type": "biolink:Cell", "ic": "92.728541327098611", "identifiers": [{"i": "CL:0002111", "l": "CD38-negative unswitched memory B cell", "d": ["An CD38-negative unswitched memory B cell is an unswitched memory B cell that has the phenotype CD38-negative, IgD-positive, CD138-negative, and IgG-negative."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4484193", "l": "Neutrophil.PMA stimulated.DHR", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C3258047", "l": "Pincer cell", "d": []}, {"i": "SNOMEDCT:725267005", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4322679", "l": "Chromosome sex pair", "d": []}]}
{"type": "biolink:Cell", "ic": "54.604756636799166", "identifiers": [{"i": "CL:0002546", "l": "embryonic blood vessel endothelial progenitor cell", "d": ["An endothelial progenitor cell that participates in angiogenesis during development."]}]}
{"type": "biolink:Cell", "ic": "80.511444690059548", "identifiers": [{"i": "CL:0000501", "l": "granulosa cell", "d": ["A supporting cell for the developing female gamete in the ovary of mammals. They develop from the coelomic epithelial cells of the gonadal ridge. Granulosa cells form a single layer around the mammalian oocyte in the primordial ovarian follicle and advance to form a multilayered cumulus oophorus surrounding the ovum in the Graafian follicle. The major functions of granulosa cells include the production of steroids and LH receptors."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1182613", "l": "Epithelial cell of nasal part of viscerocranial mucosa", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5419440", "l": "Autologous Anti-CD20 CAR Transduced CD4/CD8 Enriched T-cells MB-CART20.1", "d": []}, {"i": "NCIT:C172063", "l": "Autologous Anti-CD20 CAR Transduced CD4/CD8 Enriched T-cells MB-CART20.1", "d": ["A preparation of autologous T-lymphocytes that have been genetically modified to express a chimeric antigen receptor (CAR) targeting the tumor-associated antigen (TAA) CD20 (cluster of differentiation 20), and CD4/CD8 enriched, with potential immunostimulating and antineoplastic activities. Upon administration, MB-CART20.1 specifically recognize and kill CD20-expressing tumor cells. The CD20 antigen, a non-glycosylated cell surface phosphoprotein, is a B-cell specific cell surface antigen expressed in B-cell lineage malignancies and certain melanoma cell subpopulations."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002458", "l": "langerin-positive dermal dendritic cell", "d": ["A dermal dendritic cell that is langerin-positive and CD103-positive."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5401677", "l": "CYP-001", "d": []}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "CL:1000073", "l": "spinal cord radial glial cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157393", "l": "CD22 blasts | Blood | Cell markers", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0598613", "l": "HTC cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5216287", "l": "Neutrophils.hypersegmented|NCnc|Pt|Bld", "d": []}]}
{"type": "biolink:Cell", "ic": "61.246643653717491", "identifiers": [{"i": "CL:0000839", "l": "myeloid lineage restricted progenitor cell", "d": ["A progenitor cell restricted to the myeloid lineage."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0682693", "l": "Autonomic ganglion neuron", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1512199", "l": "Glomerular Mesangial Cells", "d": []}, {"i": "NCIT:C32685", "l": "Glomerular Mesangial Cell", "d": ["Cells found within the glomerular lobules of mammalian kidney, where they serve as structural supports, may regulate blood flow, are phagocytic and may act as accessory cells, presenting antigen in immune responses."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5554962", "l": "LMP2-specific IL-12 Secreting T Cell Receptor-transduced T-lymphocytes", "d": []}, {"i": "NCIT:C178337", "l": "LMP2-specific IL-12 Secreting T Cell Receptor-transduced T-lymphocytes", "d": ["A preparation of T-lymphocytes that have been genetically modified to encode a T-cell receptor (TCR) specific for Epstein-Barr virus (EBV) latent membrane protein (LMP) 2, with potential antineoplastic activity. Upon administration, the LMP2-specific IL-12 secreting TCR-transduced T-lymphocytes (TCR-T) recognize and bind to EBV LMP2, which may promote cell death and inhibit the growth of tumor cells expressing LMP2. In addition, IL-12 expression activates the immune system by promoting the secretion of interferon-gamma, activating natural killer cells (NKs), and inducing cytotoxic T-cell responses, which may result in both decreased cell proliferation and increased cell death in LMP2-expressing tumor cells. As a tumor associated antigen (TAA), LMP2 is expressed in various EBV-associated malignancies including nasopharyngeal cancer and EBV-positive Hodgkin lymphoma."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C4726996", "l": "Related Donor Adenovirus-specific Cytotoxic T Cells", "d": []}, {"i": "NCIT:C152980", "l": "Related Donor Adenovirus-specific Cytotoxic T Cells", "d": ["A population of allogeneic related donor cytotoxic T-lymphocytes (CTLs) specifically reactive to human adenovirus (Ad) with potential immunomodulating and anti-adenoviral activities. Upon infusion of related donor Ad-specific CTLs, these cells help reconstitute Ad-specific CTL responses in patients at risk of developing Ad infections after allogeneic stem cell transplant or in Ad-infected immunocompromised hosts. These related donor Ad-specific CTLs are manufactured with the CliniMACS Prodigy Cytokine Capture System which facilitates production of the Ad-specific CTLs."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5575124", "l": "LCAR-B38M", "d": []}]}
{"type": "biolink:Cell", "ic": "84.75972595860604", "identifiers": [{"i": "CL:1000303", "l": "fibroblast of areolar connective tissue", "d": ["A fibroblast that is part of the areolar connective tissue."]}]}
{"type": "biolink:Cell", "ic": "87.120474278337809", "identifiers": [{"i": "UMLS:C1517734", "l": "Large Multinucleated Erythroid Cell", "d": []}, {"i": "NCIT:C37055", "l": "Large Multinucleated Erythroid Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C4727553", "l": "Therapeutic Ex-vivo-treated Autologous Central Memory T Cells", "d": []}, {"i": "NCIT:C154280", "l": "Therapeutic Ex-vivo-treated Autologous Central Memory T Cells", "d": ["A preparation of autologous ex-vivo treated central memory T (Tcm) cells with potential immunostimulatory activity. Upon isolation and ex-vivo treatment through as an of yet not elucidated method, the therapeutic ex-vivo-treated autologous Tcm cells, upon reintroduction into the patient, can activate an antitumor immune response which may eradicate tumor cells."]}]}
{"type": "biolink:Cell", "ic": "84.128890093485552", "identifiers": [{"i": "CL:2000046", "l": "ventricular cardiac muscle cell", "d": ["Any cardiac muscle cell that is part of a cardiac ventricle."]}]}
{"type": "biolink:Cell", "ic": "58.506312906189315", "identifiers": [{"i": "CL:0000206", "l": "chemoreceptor cell", "d": ["A cell specialized to detect chemical substances and relay that information centrally in the nervous system. Chemoreceptors may monitor external stimuli, as in taste and olfaction, or internal stimuli, such as the concentrations of oxygen and carbon dioxide in the blood."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1515152", "l": "TE62", "d": []}, {"i": "NCIT:C20301", "l": "TE62", "d": ["Provider: Technion University, Haifa, Israel. No information from provider. This cell line meets the criteria for the use of human embryonic stem cells by federally funded researchers."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2338777", "l": "Midget ganglion cell of retina", "d": []}]}
{"type": "biolink:Cell", "ic": "84.75972595860604", "identifiers": [{"i": "UMLS:C1709190", "l": "Neoplastic Parathyroid Gland Chief Cell", "d": []}, {"i": "NCIT:C48268", "l": "Neoplastic Parathyroid Gland Chief Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:4030010", "l": "epithelial cell of proximal tubule segment 2", "d": ["Epithelial cell that is part of segment 2 (S2) of the proximal tubule epithelium."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2332053", "l": "Type Mo enteroendocrine cell", "d": []}]}
{"type": "biolink:Cell", "ic": "59.668081988194295", "identifiers": [{"i": "UMLS:C1514029", "l": "Neoplastic Epithelial Cell with Intracytoplasmic Mucin", "d": []}, {"i": "NCIT:C37116", "l": "Neoplastic Epithelial Cell with Intracytoplasmic Mucin", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0009027", "l": "transit amplifying cell of appendix", "d": ["A transit amplifying cell that is part of a crypt of Lieberkuhn of large intestine."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0229638", "l": "Neutrophilic metamyelocyte", "d": []}, {"i": "SNOMEDCT:50134008", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5216239", "l": "Leukocytes|NCnc|Pt|Plr fld", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1515889", "l": "Mouse Adrenal Subcapsular Cell", "d": []}, {"i": "NCIT:C22638", "l": "Mouse Adrenal Subcapsular Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "77.944915021140389", "identifiers": [{"i": "CL:4023042", "l": "L6 corticothalamic-projecting glutamatergic cortical neuron", "d": ["A corticothalamic-projecting neuron with a soma found in cortical layer 6."]}]}
{"type": "biolink:Cell", "ic": "85.457082654197222", "identifiers": [{"i": "CL:0000190", "l": "fast muscle cell", "d": ["A muscle cell that can develop high tension rapidly. It is usually innervated by a single alpha neuron."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:4023019", "l": "L5/6 cck, vip GABAergic interneuron (Mmus)", "d": ["A vip GABAergic cortical interneuron that expresses cck. L5/6 cck cells have soma found mainly in L5 and L6 and have large axonal arborization."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1440148", "l": "Blasts.CD5", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2324195", "l": "Cone bipolar cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5170900", "l": "Leukemia markers | Cerebral spinal fluid | Cell markers", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0000702", "l": "R5 photoreceptor cell", "d": []}]}
{"type": "biolink:Cell", "ic": "86.236661114203869", "identifiers": [{"i": "CL:0002312", "l": "somatotroph", "d": ["An acidophilic cell of the anterior pituitary that produces growth hormone, somatotropin."]}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "CL:0002441", "l": "CD94-positive natural killer cell, mouse", "d": ["A NK1.1-positive T cell that is CD94-positive."]}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "UMLS:C1881553", "l": "Malignant Epithelial Small Polygonal Cell", "d": []}, {"i": "NCIT:C60996", "l": "Malignant Epithelial Small Polygonal Cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1717809", "l": "Erythrocytes.CD55 & CD59", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5237380", "l": "UCART22", "d": []}, {"i": "NCIT:C165696", "l": "Allogeneic CD22-specific Universal CAR-expressing T-lymphocytes UCART22", "d": ["A preparation of allogeneic, off-the-shelf (OTS), universal transcription activator-like effector nuclease (TALEN)-engineered T-lymphocytes that have been genetically modified to express a chimeric antigen receptor (CAR) targeting the tumor-associated antigen (TAA) human CD22 with potential immunomodulating and antineoplastic activities. Upon transfusion, allogeneic CD22-specific universal CAR-expressing T-lymphocytes UCART22 express anti-CD22-CAR on their cell surfaces and bind to the CD22 antigen on tumor cell surfaces, resulting in lysis of CD22-expressing tumor cells. CD22, a cell surface glycoprotein, is expressed on mature B-cells and on most malignant B-cells."]}]}
{"type": "biolink:Cell", "ic": "85.457082654197222", "identifiers": [{"i": "UMLS:C0333738", "l": "Fat-laden macrophage", "d": []}, {"i": "NCIT:C36833", "l": "Lipid-Laden Macrophage", "d": []}, {"i": "SNOMEDCT:13901007", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:4023072", "l": "brain vascular cell", "d": ["A cell that is part of the brain vasculature."]}]}
{"type": "biolink:Cell", "ic": "82.076046914303362", "identifiers": [{"i": "CL:0001066", "l": "erythroid progenitor cell, mammalian", "d": ["A progenitor cell committed to the erythroid lineage. This cell is ter119-positive but lacks expression of other hematopoietic lineage markers (lin-negative)."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0000054", "l": "bone matrix secreting cell", "d": []}]}
{"type": "biolink:Cell", "ic": "82.076046914303362", "identifiers": [{"i": "CL:0000060", "l": "odontoblast", "d": ["Skeletogenic cell that secretes dentine matrix, is derived from the odontogenic papilla, and develops from a preodontoblast cell."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5382748", "l": "CD107a+b expressing HLA-B35 Cytomegalovirus specific CD8 cells | Blood | Cell markers", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5178301", "l": "Promonocytes | Body fluid | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5666888", "l": "Allogeneic Anti-CD38 DAR-T Cells STI-1492", "d": []}, {"i": "NCIT:C182613", "l": "Allogeneic Anti-CD38 DAR-T Cells STI-1492", "d": ["A preparation of human allogeneic T-lymphocytes that are gene-edited with the clustered regularly interspaced short palindromic repeats (CRISPR)-Cas9 nuclease complex to disrupt the expression of endogenous T-cell receptor (TCR) alpha and to express a dimeric antigen receptor (DAR) composed of a fragment antigen-binding variable region (Fab) recognizing the tumor-associated antigen (TAA) cluster of differentiation 38 (CD38), linked to the intracellular signaling domains of 4-1BB (CD137) and the zeta chain of the TCR/CD3 complex (TCRzeta; CD247; CD3zeta), with potential immunomodulating and antineoplastic activities. Upon intravenous administration, allogeneic anti-CD38 DAR-T cells STI-1492 are directed to and induce selective toxicity in CD38-expressing tumor cells. CD38, a type II transmembrane glycoprotein, is present on various immune cells and hematologic malignancies, and its expression has been correlated with poor prognosis. The disruption of endogenous TCR alpha prevents graft-versus-host disease (GvHD)."]}]}
{"type": "biolink:Cell", "ic": "90.82444074280258", "identifiers": [{"i": "CL:0000555", "l": "neuronal brush cell", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002181", "l": "mucous neck cell of gastric gland", "d": ["A neck cell that secretes mucus within the stomach. Its products are distinct histochemically from those of the surface mucous cells of stomach."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1525452", "l": "Cells.CD11b+CD11c+", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5554856", "l": "Donor Derived HIV-Specific T-cells with Non-escaped Epitope Targets", "d": []}, {"i": "NCIT:C178128", "l": "Donor Derived HIV-Specific T-cells with Non-escaped Epitope Targets", "d": ["A preparation of ex vivo expanded donor-derived (DD) human immunodeficiency virus (HIV)-specific T-cells (HSTs) with non-escaped epitope targets (NEETs), that can potentially be used to eliminate HIV-infected cells and eradicate HIV. Upon administration, DD HST-NEETs target and kill HIV-infected cells, thereby eradicating HIV. HST-NEETs recognize multiple conserved, non-escaped HIV epitopes and their common variants, which is important in killing latently infected cells and could reduce viral escape."]}]}
{"type": "biolink:Cell", "ic": "90.82444074280258", "identifiers": [{"i": "CL:0000924", "l": "CD4-negative, CD8-negative type I NK T cell", "d": ["A type I NK T cell that has the phenotype CD4-negative and CD8-negative."]}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "UMLS:C1257975", "l": "Mesenchymal Stem Cells", "d": []}, {"i": "NCIT:C43423", "l": "Mesenchymal Stem Cell", "d": ["An undifferentiated stromal cell with the ability to develop into the cells that form distinct mesenchymal tissues; such as bone, muscle, connective tissue, blood vessels, and lymphatic tissue."]}, {"i": "MESH:D059630", "l": "Mesenchymal Stem Cells", "d": []}, {"i": "SNOMEDCT:418124002", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157374", "l": "CD2+CD26+ cells | Blood | Cell markers", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C3496530", "l": "telencephalic dopamine cells", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C3640949", "l": "Inducible CD4+CD25+ Regulatory T Cells", "d": []}, {"i": "NCIT:C102789", "l": "Inducible CD4+CD25+ Regulatory T Cells", "d": ["Inducible regulatory T-lymphocytes that express CD4, CD25 (the alpha chain of the interleukin 2 receptor) and forkhead box P3 (FOXP3), with potential immunomodulating activity. Inducible CD4+CD25+ T regulatory cells (iTregs) are a subset of CD4+ T lymphocytes that are induced from CD25- precursors in peripheral lymphoid organs with interleukin-2 and transforming growth factor-beta. These regulatory T cells are essential in maintaining immunologic homeostasis. They may also prevent autoimmunity by suppressing self-reactive T cells, and may induce tolerance to allogeneic organ transplants such as in hematopoietic stem cell transplants."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157556", "l": "CD4+CD8+ | White blood cells | Cell markers", "d": []}]}
{"type": "biolink:Cell", "ic": "64.45299868619928", "identifiers": [{"i": "CL:0000209", "l": "taste receptor cell", "d": ["A specialized cell involved in gustatory sensory perception."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5446938", "l": "Autologous Anti-NY-ESO-1 TCR/dnTGF-BRII-expressing T-cells GSK3845097", "d": []}, {"i": "NCIT:C176041", "l": "Autologous Anti-NY-ESO-1 TCR/dnTGF-BRII-expressing T-cells GSK3845097", "d": ["A preparation of human autologous T-lymphocytes that are genetically modified to express a T-cell receptor (TCR) specific for the human cancer-testis antigen NY-ESO-1 and a dominant negative (dn) form of transforming growth factor-beta (TGF-beta; TGFb) receptor (dnTGF-BRII), with potential immunostimulating and antineoplastic activities. Upon leukapheresis, isolation, transduction, expansion ex vivo, and reintroduction into the patient, the autologous anti-NY-ESO-1 TCR/dnTGF-BRII-expressing T-cells GSK3845097 recognize and bind to NY-ESO-1-overexpressing tumor cells. This may result in a specific cytotoxic T-lymphocyte (CTL)-mediated killing of NY-ESO-1-positive tumor cells. NY-ESO-1, a tumor-associated antigen (TAA), is found in normal testis and on the surface of various tumor cell types. The inclusion of dnTGF-BRII blocks the signaling of the immunosuppressive cytokine TGFb in the tumor microenvironment (TME) and makes the GSK3845097 T-cells resistant to TGFb. TGFb negatively regulates T-cell proliferation and activation and plays a key role in tumor immune suppression."]}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "UMLS:C1709102", "l": "Myopericyte", "d": []}, {"i": "NCIT:C51141", "l": "Myopericyte", "d": []}]}
{"type": "biolink:Cell", "ic": "90.82444074280258", "identifiers": [{"i": "CL:0000651", "l": "mucous neck cell", "d": ["A mucus-secreting cell, with numerous apical secretory vesicles containing mucins; nucleus are basally displaced; numerous at the neck of mucus secreting glands"]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5167384", "l": "Histiocytes | Body fluid | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:4033006", "l": "endothelial cell of efferent lymphatic vessel", "d": ["A(n) endothelial cell that is part of a(n) efferent lymphatic vessel."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157375", "l": "CD2+CD3+ cells | XXX | Cell markers", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1514741", "l": "Reactive Squamous Cell", "d": []}, {"i": "NCIT:C36810", "l": "Reactive Squamous Cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5416843", "l": "CK0802", "d": []}]}
{"type": "biolink:Cell", "ic": "71.88020023694385", "identifiers": [{"i": "CL:0000805", "l": "immature single positive thymocyte", "d": ["A thymocyte that has the phenotype CD4-negative, CD8-positive, CD44-negative, CD25-negative, and pre-TCR-positive."]}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "CL:2000051", "l": "splenic fibroblast", "d": ["Any fibroblast that is part of a spleen."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2919941", "l": "Colony-forming unit of monocytic lineage", "d": []}, {"i": "SNOMEDCT:445094003", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157496", "l": "CD34 cells | XXX | Cell markers", "d": []}]}
{"type": "biolink:Cell", "ic": "90.82444074280258", "identifiers": [{"i": "UMLS:C1709206", "l": "Neoplastic Stellate Chondrocyte", "d": []}, {"i": "NCIT:C53472", "l": "Neoplastic Stellate Chondrocyte", "d": []}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "CL:1001596", "l": "salivary gland glandular cell", "d": ["Glandular cell of salivary gland. Example: Serous cells, mucous cells, cuboidal epithelial cells of the intercalated ducts, simple cuboidal epithelium of the striated ducts, epithelial cells of excretory ducts."]}]}
{"type": "biolink:Cell", "ic": "85.457082654197222", "identifiers": [{"i": "UMLS:C1518184", "l": "Malignant Thyroid Gland Oncocyte", "d": []}, {"i": "NCIT:C37097", "l": "Malignant Thyroid Gland Oncocyte", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0009087", "l": "fused extravillous trophoblast", "d": ["An extravillous trophoblast that is polynuclear."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1709187", "l": "Neoplastic Osteoclast-Like Giant Cell", "d": []}, {"i": "NCIT:C47815", "l": "Neoplastic Osteoclast-Like Giant Cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1440313", "l": "Cells.CD44R", "d": []}]}
{"type": "biolink:Cell", "ic": "68.25778018697109", "identifiers": [{"i": "CL:0000816", "l": "immature B cell", "d": ["An immature B cell is a B cell that has the phenotype surface IgM-positive and surface IgD-negative, and have not undergone class immunoglobulin class switching or peripheral encounter with antigen and activation."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5708969", "l": "CytoTIL15", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4518171", "l": "Population of all squamous epithelial cells in portion of fluid", "d": []}, {"i": "SNOMEDCT:726505005", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2350831", "l": "Retinal Photoreceptor Cells", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002235", "l": "luminal cell of prostatic acinus", "d": ["A cell of the luminal layer of the epithelium in the prostatic acinus."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002007", "l": "Kit-low, CD34-positive eosinophil progenitor cell", "d": ["A lineage marker-negative, CD34-positive, IL5r-alpha-positive, and Sca1-negative eosinophil progenitor cell."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5170916", "l": "Leukocytes | Bile fluid | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5148515", "l": "Plasma cells.abnormal", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5177469", "l": "Plasma cells/100 leukocytes | Blood cord | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4763339", "l": "Axonic neuron", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5670749", "l": "MC-38", "d": []}, {"i": "NCIT:C186782", "l": "MC-38", "d": ["A cell line derived from C57BL/6 murine colon adenocarcinoma cells. The cells are adherent and have a fibroblast morphology. MC38 cells will form tumors and metastases post-implantation into syngeneic C57BL/6 mice or immunocompromised mice."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0806036", "l": "Renal epithelial cell", "d": []}, {"i": "SNOMEDCT:115593006", "d": []}]}
{"type": "biolink:Cell", "ic": "92.728541327098611", "identifiers": [{"i": "UMLS:C1514031", "l": "Neoplastic Multinucleated Stromal Cell", "d": []}, {"i": "NCIT:C37124", "l": "Neoplastic Multinucleated Stromal Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "74.659114980698789", "identifiers": [{"i": "CL:0000547", "l": "proerythroblast", "d": ["An immature, nucleated erythrocyte occupying the stage of erythropoeisis that follows formation of erythroid progenitor cells. This cell is CD71-positive, has both a nucleus and a nucleolus, and lacks hematopoeitic lineage markers."]}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "UMLS:C1519464", "l": "Spindle Cell Myoblast", "d": []}, {"i": "NCIT:C36952", "l": "Spindle Cell Myoblast", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5177782", "l": "Polymorphonuclear cells | Pleural fluid | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1183202", "l": "Set of cholinergic cells", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2328210", "l": "Basal cell of epithelium of bronchus", "d": []}]}
{"type": "biolink:Cell", "ic": "82.076046914303362", "identifiers": [{"i": "CL:0002209", "l": "intermediate epitheliocyte", "d": ["An epithelial cell present in the trachea and bronchi; columnar in shape; generally lack cilia; immature forms of ciliated or secretory cells which have been formed from stem cells."]}]}
{"type": "biolink:Cell", "ic": "80.511444690059548", "identifiers": [{"i": "CL:0019002", "l": "tracheobronchial chondrocyte", "d": ["Any chondrocyte that is part of the tracheobronchial tree."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0427889", "l": "Vaginal epithelial cell", "d": []}, {"i": "SNOMEDCT:91766007", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1440352", "l": "Cells.CD73", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1511463", "l": "CY12", "d": []}, {"i": "NCIT:C20237", "l": "CY12", "d": ["Provider: CyThera, Inc., San Diego, CA. No information from provider. This cell line meets the criteria for the use of human embryonic stem cells by federally funded researchers."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1440229", "l": "Cells.aneuploid.population 1", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C3172555", "l": "Ciliated epithelial cell", "d": []}, {"i": "SNOMEDCT:725724001", "d": []}]}
{"type": "biolink:Cell", "ic": "40.966874972451535", "identifiers": [{"i": "UMLS:C1510716", "l": "Abnormal Connective and Soft Tissue Cell", "d": []}, {"i": "NCIT:C36843", "l": "Abnormal Connective and Soft Tissue Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:1000323", "l": "pyloric gastric gland goblet cell", "d": ["A goblet cell that is part of the epithelium of pyloric gland."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2339863", "l": "Transitional myocyte of atrioventricular node", "d": []}]}
{"type": "biolink:Cell", "ic": "92.728541327098611", "identifiers": [{"i": "CL:1001066", "l": "kidney arteriole smooth muscle cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0229637", "l": "Neutrophilic myelocyte", "d": []}, {"i": "SNOMEDCT:4717004", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4253021", "l": "Set of type A cells of pancreatic islet", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1181285", "l": "Prickle cell of epidermis", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0282501", "l": "Spheroids, Cellular", "d": []}, {"i": "MESH:D018874", "l": "Spheroids, Cellular", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157458", "l": "CD3+CD8+ (T8 suppressor) cells | XXX | Cell markers", "d": []}]}
{"type": "biolink:Cell", "ic": "81.648881485605159", "identifiers": [{"i": "CL:2000008", "l": "microvascular endothelial cell", "d": ["Any blood vessel endothelial cell that is part of a microvascular endothelium."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1513976", "l": "Neoplastic Glandular Cell with Enlarged Nucleus and Prominent Nucleolus", "d": []}, {"i": "NCIT:C37128", "l": "Neoplastic Glandular Cell with Enlarged Nucleus and Prominent Nucleolus", "d": []}]}
{"type": "biolink:Cell", "ic": "80.869303025598512", "identifiers": [{"i": "UMLS:C1711389", "l": "Neoplastic Erythroblast", "d": []}, {"i": "NCIT:C43217", "l": "Neoplastic Erythroblast", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:4030016", "l": "epithelial cell of early distal convoluted tubule", "d": ["An epithelial cell located in the early distal convoluted tubule."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1545529", "l": "Invasive trophoblast", "d": []}]}
{"type": "biolink:Cell", "ic": "90.82444074280258", "identifiers": [{"i": "UMLS:C1882052", "l": "Neoplastic Epithelial Small Polygonal Cell", "d": []}, {"i": "NCIT:C60993", "l": "Neoplastic Epithelial Small Polygonal Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "52.491931192834926", "identifiers": [{"i": "CL:0010017", "l": "zygote", "d": ["A zygote in a plant or an animal."]}]}
{"type": "biolink:Cell", "ic": "71.975435936396124", "identifiers": [{"i": "CL:0000244", "l": "transitional epithelial cell", "d": ["A cell characteristically found lining hollow organs that are subject to great mechanical change due to contraction and distention; originally thought to represent a transition between stratified squamous and columnar epithelium."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C3251824", "l": "Cell positive for CD4 antigen", "d": []}, {"i": "SNOMEDCT:116745007", "d": []}]}
{"type": "biolink:Cell", "ic": "85.457082654197222", "identifiers": [{"i": "UMLS:C1513996", "l": "Neoplastic Large B-Lymphocyte with Pale Cytoplasm", "d": []}, {"i": "NCIT:C38660", "l": "Neoplastic Large B-Lymphocyte with Pale Cytoplasm", "d": []}]}
{"type": "biolink:Cell", "ic": "92.728541327098611", "identifiers": [{"i": "CL:1000414", "l": "endothelial cell of venule", "d": ["An endothelial cell that is part of the venule."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5174612", "l": "Neutrophils | Blood | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157495", "l": "CD34 cells | Body fluid | Cell markers", "d": []}]}
{"type": "biolink:Cell", "ic": "82.532694649739099", "identifiers": [{"i": "CL:1001601", "l": "adrenal gland glandular cell", "d": ["Hormone secreting cell located in the cortex of adrenal gland. Glandular cells in the adrenal cortex secrete mineralocorticoids, glucocorticoids and androgens."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:4023001", "l": "static beta motor neuron", "d": ["A beta motor neuron that innervates nuclear chain fibers."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C3496533", "l": "A13 dopamine cells", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5706465", "l": "Autologous Anti-CD7 CAR T-cells SENL101", "d": []}, {"i": "NCIT:C188233", "l": "Autologous Anti-CD7 CAR T-cells SENL101", "d": ["A preparation of autologous T-lymphocytes that have been genetically engineered to express a chimeric antigen receptor (CAR) directed against the tumor-associated antigen (TAA) CD7, with potential immunostimulating and antineoplastic activities. Upon intravenous administration, the autologous anti-CD7 CAR T-cells SENL101 specifically recognize and bind to CD7-expressing tumor cells, resulting in specific T-cell-mediated tumor cell lysis. CD7 is a transmembrane glycoprotein expressed by T-cells and natural killer (NK) cells and their precursors. It is expressed in the majority of lymphoblastic T-cell leukemias and lymphomas and in a subset of peripheral T-cell lymphomas."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1517915", "l": "Mouse Ito Cell", "d": []}, {"i": "NCIT:C22519", "l": "Mouse Ito Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "87.120474278337809", "identifiers": [{"i": "CL:0000395", "l": "procrystal cell", "d": ["A precursor of mature crystal cells."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4484160", "l": "Cells.FMRP", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:1000377", "l": "dense-core granulated cell of epithelium of trachea", "d": ["A Feyrter cell that is part of the epithelium of trachea."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0008021", "l": "anterior lateral line ganglion neuron", "d": []}]}
{"type": "biolink:Cell", "ic": "72.79108406015925", "identifiers": [{"i": "CL:1000507", "l": "kidney tubule cell", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0009084", "l": "epithelial cell of endometrial gland", "d": ["An epithelial cell that is part of an endometrial gland."]}]}
{"type": "biolink:Cell", "ic": "56.307996466303948", "identifiers": [{"i": "CL:0002031", "l": "hematopoietic lineage restricted progenitor cell", "d": ["A hematopoietic progenitor cell that is capable of developing into only one lineage of hematopoietic cells."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4518164", "l": "Population of all spermatozoa with abnormal head in portion of fluid", "d": []}, {"i": "SNOMEDCT:725222003", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4080738", "l": "human cord blood hematopoietic progenitor cell 500000000 in 25 mL INTRAVENOUS INJECTION, SUSPENSION [CORDCYTE]", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5163446", "l": "Eosinophils | Stool | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:1001575", "l": "uterine cervix squamous cell", "d": ["Squamous cell of uterine cervix epithelium."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0009105", "l": "T cell zone reticular cell", "d": ["A fibroblastic reticular cell found in the lymph node T cell domain."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5163724", "l": "Erythrocytes | Semen | Fertility testing", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0882920", "l": "Cell positive for CD7 antigen", "d": []}, {"i": "SNOMEDCT:116747004", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5690234", "l": "Other cells | Amniotic fluid | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5221143", "l": "Leukocytes|NCnc|Pt|Dial fld", "d": []}]}
{"type": "biolink:Cell", "ic": "79.246894609297499", "identifiers": [{"i": "UMLS:C1518995", "l": "Peripheral B-Lymphocyte of Inner Mantle Zone", "d": []}, {"i": "NCIT:C38332", "l": "Peripheral B-Lymphocyte of Inner Mantle Zone", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2825117", "l": "AlloStim", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C0314589", "l": "Granulocyte-Macrophage Colony Forming Units", "d": []}, {"i": "NCIT:C121475", "l": "Granulocyte-Macrophage Colony Forming Unit", "d": ["A unit of viable cell concentration defined as the minimum number of hematopoietic stem cells able to produce a detectable colony of granulocyte-macrophage lineage cells."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:4030057", "l": "eccentric medium spiny neuron", "d": ["A medium spiny neuron that exhibits transcriptional divergence from direct and indirect spiny projection neurons, for example, enrichment in Casz1, Otof, Cacng5 and Pcdh8 noted in mice. Whilst in general medium spiny neurons have been found to be differentially distributed across the basal ganglia, the eccentric medium spiny neuron cell type has been found to be more evenly distributed throughout cerebral nuclei."]}]}
{"type": "biolink:Cell", "ic": "74.659114980698789", "identifiers": [{"i": "UMLS:C1516090", "l": "Atypical Chondrocyte", "d": []}, {"i": "NCIT:C36984", "l": "Atypical Chondrocyte", "d": []}]}
{"type": "biolink:Cell", "ic": "83.552982069901191", "identifiers": [{"i": "CL:0002418", "l": "hemangioblast", "d": ["A pluripotent cell in the yolk sac that can give rise to mesenchymal cells including erythrocytes and endothelial cells."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1512138", "l": "ESO-1 Reactive Autologous Tumor Infiltrating Lymphocyte", "d": []}, {"i": "NCIT:C38120", "l": "ESO-1 Reactive Autologous Tumor Infiltrating Lymphocyte", "d": ["Tumor infiltrating lymphocytes (TIL) isolated from a patient, exposed to the tumor-associated protein ESO-1 in vitro, and then transferred back to the same patient to target tumor cells expressing ESO-1. ESO-1 is a human self-antigen expressed by melanomas. The ESO-1 gene encodes several MHC class I- and MHC class II-restricted epitopes which may activate cytotoxic T-cell-mediated tumor destruction. (NCI04)"]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5555028", "l": "Allogeneic CD19CAR-CD28-CD3-zeta-expressing T-lymphocytes", "d": []}, {"i": "NCIT:C178433", "l": "Allogeneic CD19CAR-CD28-CD3-zeta-expressing T-lymphocytes", "d": ["A preparation of allogeneic, donor-derived T-lymphocytes that have been genetically modified to express a chimeric antigen receptor (CAR) consisting of an anti-CD19 scFv (single chain variable fragment), fused to the extracellular, transmembrane and intracellular signaling domains of the T-cell co-stimulatory receptor CD28 and the cytoplasmic signaling domain of the zeta chain of the TCR/CD3 complex (CD3-zeta) (19-28z), with potential immunostimulating and antineoplastic activities. Upon administration, allogeneic CD19CAR-CD28-CD3-zeta-expressing T-lymphocytes are directed to CD19-expressing tumor cells, which induces selective toxicity in CD19-expressing tumor cells. CD19 antigen is a B-cell specific cell surface antigen expressed in all B-cell lineage malignancies. The CD28 co-stimulatory molecule signaling domain enhances activation and signaling after recognition of CD19. The inclusion of the CD28 signaling domain may increase proliferation of T-cells and antitumor activity compared to the inclusion of the CD3-zeta chain alone."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0003026", "l": "retinal ganglion cell D1", "d": ["A bistratified retinal ganglion cell that has a small dendrite fields with a sparse dendrite arbor terminating in S2 and S3."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1254945", "l": "Okt3 Lymphocyte", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1267880", "l": "Lymphocyte positive for both CD16C antigen and CD56 antigen", "d": []}, {"i": "SNOMEDCT:117557005", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5691293", "l": "Intestinal Villous M Cells", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157261", "l": "CD117 blasts | Bone marrow | Cell markers", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4521533", "l": "Donor lymphocytes for infusion (specimen)", "d": []}, {"i": "SNOMEDCT:456891000124106", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0000976", "l": "IgA short lived plasma cell", "d": ["A short lived plasma cell that secretes IgA. These cells may be found in the bone marrow as well as in the mucosal immune system."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1317119", "l": "Immature basophils", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2327375", "l": "Fibroblast of subepithelial connective tissue of prostatic gland", "d": []}]}
{"type": "biolink:Cell", "ic": "68.368095522595297", "identifiers": [{"i": "UMLS:C0227525", "l": "Hepatocyte", "d": []}, {"i": "NCIT:C12588", "l": "Hepatocyte", "d": ["A parenchymal liver cell."]}, {"i": "MESH:D022781", "l": "Hepatocytes", "d": []}, {"i": "SNOMEDCT:30396005", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1979102", "l": "Blasts.CD123", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5419628", "l": "Autologous CD19/PD-1 Bispecific CAR-T Cells", "d": []}, {"i": "NCIT:C172387", "l": "Autologous CD19/PD-1 Bispecific CAR-T Cells", "d": ["A preparation of autologous T-lymphocytes that are transduced with a lentiviral vector encoding a chimeric antigen receptor (CAR) specific for the tumor-associated antigen (TAA) cluster of differentiation 19 (CD19) and a programmed cell death protein 1 (PD1)/CD28 chimera, with potential immunomodulating and antineoplastic activities. Upon reintroduction into the patient, the autologous CD19/PD-1 bispecific CAR-T cells target and bind to CD19 and the PD-1 ligands, programmed cell death ligand 1 (PD-L1) and 2 (PD-L2), expressed on tumor cells. The binding to CD19 leads to a cytotoxic T-lymphocyte (CTL) response against CD19-expressing tumor cells and cell lysis of these cells. The binding of the PD1/CD28 chimera to PD-L1 prevents the normal PD1/PD-L1-mediated T-cell suppression and, instead, promotes signaling through the CD28 domain, which results in the stimulation of T-lymphocytes. This enhances T-lymphocyte proliferation and anti-tumor activity. CD19 antigen is a B-cell specific cell surface antigen overexpressed in B-cell lineage malignancies. PD-1 protein, found on activated T-cells, negatively regulates T-cell activity. It plays a key role in immune evasion and prevents tumor cell lysis. The construct of the PD1/CD28 chimera converts PD-L1 into a co-stimulation ligand of primary human CD8+ cytotoxic T-lymphocytes (CTLs). CD28 is a costimulatory molecule expressed by T-cells that enhances T-lymphocyte proliferation and activity."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5174093", "l": "Myeloblasts/100 cells | Bone marrow | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5170941", "l": "Leukocytes | Synovial fluid | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5216193", "l": "Basophils|NCnc|Pt|Plr fld", "d": []}]}
{"type": "biolink:Cell", "ic": "78.695011174409487", "identifiers": [{"i": "CL:0012000", "l": "astrocyte of the forebrain", "d": ["An astrocyte of the forebrain."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:4023053", "l": "spinal interneuron synapsing Betz cell", "d": ["A Betz cell that syanpses with spinal interneurons."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5216277", "l": "Monocytes|NCnc|Pt|Synv fld", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5170008", "l": "Kappa lymphocytes | Blood | Cell markers", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0001046", "l": "memory CCR4-positive regulatory T cell", "d": ["A memory regulatory T cell with phenotype CD4-positive, CD25-positive, CD127lo, CCR4-positive, and CD45RO-positive."]}]}
{"type": "biolink:Cell", "ic": "80.869303025598512", "identifiers": [{"i": "CL:0000788", "l": "naive B cell", "d": ["A naive B cell is a mature B cell that has the phenotype surface IgD-positive, surface IgM-positive, CD20-positive, CD27-negative and that has not yet been activated by antigen in the periphery."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157513", "l": "CD38+CD138+ cells | Blood | Cell markers", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5401598", "l": "Mesenchymoangioblast-derived mesenchymal stem cells", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0227693", "l": "Umbrella cell", "d": []}, {"i": "SNOMEDCT:16023000", "d": []}]}
{"type": "biolink:Cell", "ic": "84.75972595860604", "identifiers": [{"i": "CL:0002006", "l": "Kit-positive, CD34-negative megakaryocyte erythroid progenitor cell", "d": ["A megakaryocyte erythroid progenitor cell that is Kit-positive and is Sca1-negative, CD34-negative, CD90-negative, IL7r-alpha-negative and Fcgr II/III-low."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:1000368", "l": "transitional myocyte of anterior division of left branch of atrioventricular bundle", "d": ["A transitional myocyte that is part of the anterior division of left branch of atrioventricular bundle."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:1000466", "l": "chromaffin cell of right ovary", "d": ["A chromaffin cell that is part of the right ovary."]}]}
{"type": "biolink:Cell", "ic": "71.88020023694385", "identifiers": [{"i": "CL:0000050", "l": "megakaryocyte-erythroid progenitor cell", "d": ["A progenitor cell committed to the megakaryocyte and erythroid lineages."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5163439", "l": "Eosinophils | Fetus | Blood | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C3495561", "l": "A7 noradrenaline cells", "d": []}]}
{"type": "biolink:Cell", "ic": "86.236661114203869", "identifiers": [{"i": "CL:0000908", "l": "CD8-positive, alpha-beta cytokine secreting effector T cell", "d": ["A CD8-positive, alpha-beta T cell with the phenotype CD69-positive, CD62L-negative, CD127-negative, and CD25-positive, that secretes cytokines."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5421409", "l": "Anti-HER2 oNK Cells", "d": []}]}
{"type": "biolink:Cell", "ic": "87.120474278337809", "identifiers": [{"i": "CL:0000503", "l": "theca cell", "d": ["A flattened stroma cell forming a sheath or theca outside the basal lamina lining the mature ovarian follicle. Thecal interstitial or stromal cells are steroidogenic, and produce primarily androgens which serve as precusors of estrogens in the granulosa cells."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C3640055", "l": "IGF-1R antisense oligodeoxynucleotide-treated autologous glioma cells", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1267903", "l": "Lymphocyte positive for CD30 antigen", "d": []}, {"i": "SNOMEDCT:117574005", "d": []}]}
{"type": "biolink:Cell", "ic": "75.923665061460838", "identifiers": [{"i": "UMLS:C1265916", "l": "Abnormal macrophage", "d": []}, {"i": "NCIT:C36832", "l": "Abnormal Macrophage", "d": []}, {"i": "SNOMEDCT:127565009", "d": []}]}
{"type": "biolink:Cell", "ic": "87.120474278337809", "identifiers": [{"i": "CL:1000334", "l": "enterocyte of epithelium of small intestine", "d": ["An enterocyte that is part of the epithelium of small intestine."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1113654", "l": "Neural Stem Cells", "d": []}, {"i": "NCIT:C12985", "l": "Neural Stem Cell", "d": ["A stem cell derived from embryonic sources or found in adult neural tissue. It has the capacity to generate all the multiple cell types found in the brain and spinal cord."]}, {"i": "MESH:D058953", "l": "Neural Stem Cells", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5687321", "l": "Population of all eosinophilic myelocytes in portion of fluid", "d": []}, {"i": "SNOMEDCT:1208767001", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0314595", "l": "Colony-forming unit of neutrophilic-monocytic lineage", "d": []}, {"i": "SNOMEDCT:445287005", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1180273", "l": "Myoepithelial cell of terminal lactiferous duct", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4038423", "l": "cervical cells", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0009056", "l": "transit amplifying cell of anorectum", "d": ["A transit amplifying cell that is located in the anorectum."]}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "UMLS:C0206116", "l": "Microglia", "d": []}, {"i": "NCIT:C12616", "l": "Microglia", "d": ["A type of glial cell that mediates immune responses by clearing cellular debris and dead neurons from nervous tissue through phagocytosis."]}, {"i": "MESH:D017628", "l": "Microglia", "d": []}, {"i": "SNOMEDCT:63483002", "d": []}]}
{"type": "biolink:Cell", "ic": "92.728541327098611", "identifiers": [{"i": "UMLS:C1514179", "l": "Pleomorphic Small T-Lymphocyte", "d": []}, {"i": "NCIT:C39601", "l": "Pleomorphic Small T-Lymphocyte", "d": []}]}
{"type": "biolink:Cell", "ic": "85.457082654197222", "identifiers": [{"i": "CL:0002417", "l": "primitive erythroid lineage cell", "d": ["An immature or mature cell of the first erythroid lineage to arise during embryonic development."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157505", "l": "CD36 blasts | Bone marrow | Cell markers", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157917", "l": "Cell type | XXX | Cell markers", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1267816", "l": "Lymphocyte positive for CD3 antigen", "d": []}, {"i": "SNOMEDCT:116852002", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0598536", "l": "follicular epithelial cell", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1511006", "l": "BG01", "d": []}, {"i": "NCIT:C20233", "l": "BG01", "d": ["Provider: BresaGen, Inc., Athens, GA. Information from provider and not independently verified by NIH: Cells are positive for cell markers SSEA-3, SSEA-4, TRA 1-60, TRA 1-81, Oct-4, and alkaline phosphatase; Cells are negative for the cell marker SSEA1. This cell line meets the criteria for the use of human embryonic stem cells by federally funded researchers."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C2328961", "l": "Type 1 vestibular sensory cell", "d": []}, {"i": "NCIT:C12630", "l": "Type I Hair Cell", "d": ["A flask-shaped mechanoreceptor cell that detects and transduces head movements into neural impulses and is located within the vestibular systems of mammals, birds, and reptiles."]}, {"i": "SNOMEDCT:2246008", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C2697996", "l": "Allogeneic LMP1/LMP2-Specific Cytotoxic T-Lymphocytes", "d": []}, {"i": "NCIT:C78201", "l": "Allogeneic LMP1/LMP2-Specific Cytotoxic T-Lymphocytes", "d": ["A preparation of cytotoxic T-lymphocytes (CTL), specifically reactive to the Epstein-Barr virus (EBV) latent membrane proteins (LMP) 1 and 2, with potential antineoplastic activity. Peripheral blood mononuclear cells (PBMC) are collected from a donor and are exposed ex vivo to dendritic cells (DCs) transfected with a replication-deficient adenovirus encoding EBV LMP1/2 to generate LMP1/2-specific CTL which are subsequently expanded. Administration of allogeneic LMP1-/LMP2- specific CTL to patients with LMP1/2-positive tumors may result in a specific CTL response against tumor cells expressing LMP1 and LMP2, resulting in cell lysis and inhibition of tumor cell proliferation. As tumor associated antigens (TAAs), LMP1 and LMP2 are expressed in various malignancies including nasopharyngeal cancer and EBV-positive Hodgkin lymphoma."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0541681", "l": "Marrow Monocytes and Plasma Cells", "d": []}]}
{"type": "biolink:Cell", "ic": "89.347505587204751", "identifiers": [{"i": "CL:1001561", "l": "vomeronasal sensory neuron", "d": ["Chemosensitive cells that innervate the vomernasal organ epithelium and are responsible for receiving and transmitting pheromone signals."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4518157", "l": "Population of all normal spermatozoa in portion of fluid", "d": []}, {"i": "SNOMEDCT:726441008", "d": []}]}
{"type": "biolink:Cell", "ic": "90.82444074280258", "identifiers": [{"i": "CL:4023030", "l": "L2/3/5 fan Martinotti sst GABAergic interneuron (Mmus)", "d": ["A sst GABAergic cortical interneuron that has \"fanning-out' Martinotti morphology that is found in layer 2/3/5 of the cerebral cortex. They have local axon arbor and long ascending axons that spreads horizontally and arborizes significantly in L1."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1182642", "l": "Urothelial cell of trigone of urinary bladder", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2336716", "l": "Stromal cell of ovarian medulla", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5154297", "l": "Band form neutrophils | Blood | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1516095", "l": "Atypical Fibroblastic Spindle Cell", "d": []}, {"i": "NCIT:C36956", "l": "Atypical Fibroblastic Spindle Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C4287750", "l": "JCAR014", "d": []}, {"i": "NCIT:C126639", "l": "Autologous Anti-CD19CAR-4-1BB-CD3zeta-EGFRt-expressing CD4+/CD8+ Central Memory T-lymphocytes JCAR014", "d": ["A defined preparation of CD4+ and CD8+ central memory (CM) autologous T-lymphocytes transduced with a lentiviral vector expressing a chimeric antigen receptor (CAR) containing an anti-CD19 single chain variable fragment (scFv) fused to the signaling domains of CD28, 4-1BB (CD137), the zeta chain of the TCR/CD3 complex (CD3-zeta), and a truncated form of the human epidermal growth factor receptor (EGFRt), with potential immunostimulating and antineoplastic activities. Upon intravenous administration, autologous anti-CD19CAR-4-1BB-CD3zeta-EGFRt-expressing CD4+/CD8+CM T-lymphocytes JCAR014 are directed to and induce selective toxicity in CD19-expressing tumor cells. CD19 antigen is a B-cell specific cell surface antigen expressed in all B-cell lineage malignancies. Devoid of both ligand binding domains and tyrosine kinase activity, the expressed EGFRt both facilitates in vivo detection of the administered, transduced T-cells and can promote elimination of those cells through a cetuximab-induced antibody dependent cellular cytotoxicity (ADCC) response. The 4-1BB costimulatory signaling domain enhances both proliferation of T-cells and antitumor activity."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0871657", "l": "Auditory Neurons", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1956157", "l": "Suppressor T-Lymphocytes, CD8-Positive", "d": []}]}
{"type": "biolink:Cell", "ic": "89.347505587204751", "identifiers": [{"i": "CL:1001503", "l": "olfactory bulb tufted cell", "d": ["The principal glutaminergic neuron located in the outer third of the external plexiform layer of the olfactory bulb; a single short primary dendrite traverses the outer external plexiform layer and terminates within an olfactory glomerulus in a tuft of branches, where it receives the input from olfactory receptor neuron axon terminals; axons of the tufted cells transfer information to a number of areas in the brain, including the piriform cortex, entorhinal cortex, olfactory tubercle, and amygdala."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5667010", "l": "Autologous Anti-mesothelin CAR-IL-7-CCL19-expressing T-lymphocytes TAK-103", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C3831168", "l": "CD33CAR-CD3zeta-4-1BB-expressing Autologous T-Lymphocytes", "d": []}, {"i": "NCIT:C107190", "l": "CD33CAR-CD3zeta-4-1BB-expressing Autologous T-Lymphocytes", "d": ["Autologous T-lymphocytes transduced with a retroviral vector expressing a chimeric antigen receptor (CAR) consisting of an anti-CD33 scFv (single chain variable fragment) coupled to the signaling domain of 4-1BB (CD137) and the zeta chain of the T-cell receptor (TCRzeta), with potential immunomodulating and antineoplastic activities. Upon transfusion, CD33-specific CAR retroviral vector-transduced autologous T lymphocytes target CD33-expressing tumor cells and induce selective toxicity in CD33-expressing tumor cells. Following binding to CD33, the 4-1BB co-stimulatory molecule signaling domain enhances both activation and signaling. Inclusion of the 4-1BB signaling domain may also increase the antitumor activity when compared to the inclusion of the CD3-zeta chain alone. CD33 is expressed on normal non-pluripotent hematopoietic stem cells as well as on myeloid leukemia cells."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0009047", "l": "macrophage of medullary sinus of lymph node", "d": ["A macrophage found in the medullary sinus of the lymph node."]}]}
{"type": "biolink:Cell", "ic": "89.347505587204751", "identifiers": [{"i": "UMLS:C1882044", "l": "Neoplastic Apocrine Cell with Eosinophilic Granular Cytoplasm", "d": []}, {"i": "NCIT:C62207", "l": "Neoplastic Apocrine Cell with Eosinophilic Granular Cytoplasm", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2919569", "l": "Colony-forming unit of granulocytic-macrophagocytic lineage (cell)", "d": []}, {"i": "SNOMEDCT:444994007", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5221011", "l": "Myeloblasts|NCnc|Pt|Bld", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C3641120", "l": "Plasmacytoid Dendritic Cell Vaccine", "d": []}, {"i": "NCIT:C103192", "l": "Plasmacytoid Dendritic Cell Vaccine", "d": ["A whole cell vaccine derived from a distinct subset of dendritic cells (DCs) with a plasma cell-like morphology that exhibits immunomodulating activity. Plasmacytoid dendritic cells (pDCs) express a characteristic set of surface markers, such as CD123 (interleukin-3 receptor alpha chain), BDCA-2 (blood dendritic cell antigen 2; CD303) and BDCA-4 (CD304), as well as intracellular toll-like receptors 7 and 9. Upon stimulation, the activated pDCs produce substantial amounts of interferon (IFN) alpha, and to a lesser degree IFN-beta, as well as other cytokines and chemokines, such as tumor necrosis factor alpha and interleukins 1, 6 and 8. In addition, these pDCs, directly or indirectly stimulate T-cells, B-cells and natural killer cells. This may potentially lead to increased immunity against tumor cells."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5186735", "l": "Leukocytes | Fetus | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002588", "l": "smooth muscle cell of the umbilical vein", "d": ["A smooth muscle cell of the umbilical vein."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5172549", "l": "Metamyelocytes | Fetus | Blood | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5174638", "l": "Neutrophils.dysplastic | Blood | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5181335", "l": "Spermatozoa | Urine | Urinalysis", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4298893", "l": "Cells.CD3+CD4+CD45RO+", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157365", "l": "CD2 blasts | Blood | Cell markers", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1440142", "l": "Blasts.CD14", "d": []}]}
{"type": "biolink:Cell", "ic": "92.728541327098611", "identifiers": [{"i": "CL:1001517", "l": "stomach enteroendocrine cell", "d": ["The various hormone- or neurotransmitter-secreting cells present throughout the mucosa of the stomach."]}]}
{"type": "biolink:Cell", "ic": "89.347505587204751", "identifiers": [{"i": "UMLS:C1514088", "l": "Neoplastic Small Immature Neuroepithelial Cell", "d": []}, {"i": "NCIT:C41836", "l": "Neoplastic Small Immature Neuroepithelial Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1511008", "l": "BG03", "d": []}, {"i": "NCIT:C20235", "l": "BG03", "d": ["Provider: BresaGen, Inc., Athens, GA. Information from provider and not independently verified by NIH: Cells are positive for cell markers SSEA-3, SSEA-4, TRA 1-60, TRA 1-81, Oct-4, and alkaline phosphatase; Cells are negative for the cell marker SSEA1. This cell line meets the criteria for the use of human embryonic stem cells by federally funded researchers."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2323503", "l": "Set of leukocytes", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157319", "l": "CD15 blasts | XXX | Cell markers", "d": []}]}
{"type": "biolink:Cell", "ic": "86.236661114203869", "identifiers": [{"i": "CL:0002484", "l": "epithelial melanocyte", "d": ["A melanocyte that produces pigment in the epithelium."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5176526", "l": "Pelger Huet cells | Blood | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5700402", "l": "Autologous Anti-BCMA Centyrin-based Chimeric Antigen Receptor-expressing Tscm", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0882934", "l": "Cells.CD8+CD38+", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C4764035", "l": "Umbilical Cord Blood-derived CD4+/CD25+ T-regulatory Cells CK0801", "d": []}, {"i": "NCIT:C158084", "l": "Umbilical Cord Blood-derived CD4+/CD25+ T-regulatory Cells CK0801", "d": ["A preparation composed of allogeneic umbilical cord blood (UCB)-derived, ex vivo expanded and enhanced CD4+/CD25+ T-regulatory cells (Tregs) with potential immunomodulatory activity. Upon administration, the UCB-derived CD4+/CD25+ Tregs CK0801 may promote immunologic homeostasis and prevent autoimmunity by suppressing self-reactive T-cells. This may induce tolerance to allogeneic organ transplants, prevent graft-versus-host disease (GvHD), and suppress autoimmune pathology."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4267708", "l": "100 cells.CD3+CD8+", "d": []}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "CL:1000042", "l": "forebrain neuroblast", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1267673", "l": "Ovum of parasite (cell)", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5571734", "l": "Acanthocytes|Urine/Urine sed", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1179549", "l": "Epithelial cell of esophagus", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1267884", "l": "Lymphocyte positive for CD18 antigen", "d": []}, {"i": "SNOMEDCT:117561004", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2736934", "l": "Cells.CD5+FMC7+", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1512636", "l": "Immature Myxoid Mesenchymal Cell", "d": []}, {"i": "NCIT:C37119", "l": "Immature Myxoid Mesenchymal Cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1292097", "l": "IgA B lymphocyte", "d": []}, {"i": "SNOMEDCT:115603005", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2323784", "l": "Fibroblast of connective tissue of glandular part of prostate", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5177461", "l": "Plasma cells.abnormal marker pattern/Cells counted | Bone marrow | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2363032", "l": "Epithelial cell of viscerocranial mucosa", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1440374", "l": "Cells.CD98", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5168982", "l": "Immature monocytes | Blood | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5181333", "l": "Spermatogonia | Semen | Fertility testing", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5540451", "l": "allogeneic cultured keratinocytes and dermal fibroblasts in murine collagen", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0000631", "l": "labyrinth supporting cell", "d": ["Cells forming a framework supporting the organ of Corti. Specific cells are those of Claudius, Deiters and Hensen."]}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "UMLS:C2828335", "l": "Balloon Melanoma Cell", "d": []}, {"i": "NCIT:C62403", "l": "Balloon Melanoma Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "UMLS:C1518056", "l": "Lymphoblast-Like Neoplastic B-Lymphocyte", "d": []}, {"i": "NCIT:C39748", "l": "Lymphoblast-Like Neoplastic B-Lymphocyte", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:2000094", "l": "nasal cavity respiratory epithelium epithelial cell of viscerocranial mucosa", "d": ["Any epithelial cell of viscerocranial mucosa that is part of a nasal cavity respiratory epithelium."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "MESH:D034101", "l": "Sporozoites", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1441340", "l": "100 cells", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1520164", "l": "Xanthoma Cell", "d": []}, {"i": "NCIT:C36845", "l": "Xanthoma Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C0242277", "l": "Proerythroblasts", "d": []}, {"i": "NCIT:C13129", "l": "Proerythroblast", "d": ["The earliest of four stages in development of the normoblast."]}, {"i": "SNOMEDCT:16671004", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4277534", "l": "Oogonial Stem Cells", "d": []}, {"i": "MESH:D000072977", "l": "Oogonial Stem Cells", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1267863", "l": "Lymphocyte positive for both CD10 antigen and CD20 antigen", "d": []}, {"i": "SNOMEDCT:117544002", "d": []}]}
{"type": "biolink:Cell", "ic": "92.728541327098611", "identifiers": [{"i": "CL:0002149", "l": "epithelial cell of uterus", "d": ["An epithelial cell of the uterus."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0546496", "l": "P.B. monoblast", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:4033014", "l": "peg cell", "d": ["A small, narrow, peg-shaped epithelial cell with little cytoplasm that is part of oviduct epithelium. This cell is rarer than the ciliated and secretory epithelial cells of the fallopian tube epithelium and is often found intercalated between them. Peg cells are generally distributed basally along the epithelium and have been found in high concentrations at the fimbriated, distal end of the fallopian tube in humans. It may have a regenerative/stem-cell function. In humans, markers include EPCAM, CD44, and ITGA6."]}]}
{"type": "biolink:Cell", "ic": "72.370703631459492", "identifiers": [{"i": "UMLS:C0039215", "l": "CD4 Positive T Lymphocytes", "d": []}, {"i": "NCIT:C12537", "l": "CD4-Positive T-Lymphocyte", "d": []}, {"i": "MESH:D015496", "l": "CD4-Positive T-Lymphocytes", "d": []}, {"i": "SNOMEDCT:115412003", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002099", "l": "type I cell of adrenal cortex", "d": ["A small, polyhedral, cell found in rounded groups or curved columns with deeply staining nuclei, scanty basophilic cytoplasm and a few lipid droplets. This cell in the zona glomerulosa produces mineralocorticoids."]}]}
{"type": "biolink:Cell", "ic": "80.869303025598512", "identifiers": [{"i": "UMLS:C1512944", "l": "Intraepithelial Lymphocytes", "d": []}, {"i": "NCIT:C38331", "l": "Intraepithelial T-Lymphocyte", "d": ["A mature T lymphocyte that migrates into epithelial tissue and contributes to the local and the systemic immune response."]}, {"i": "MESH:D000075942", "l": "Intraepithelial Lymphocytes", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C4725930", "l": "Autologous Ovarian Cancer Immunogene-modified T Lymphocytes", "d": []}, {"i": "NCIT:C150696", "l": "Autologous Ovarian Cancer Immunogene-modified T Lymphocytes", "d": ["A preparation of autologous immunogene modified T-lymphocytes (IgT) that have been genetically engineered to be specifically reactive to ovarian cancer (OC) cells, with potential antineoplastic and immunostimulating activities. Upon administration of the autologous OC-IgT cells, the T-cells recognize and induce specific toxicity in the OC cells."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2334101", "l": "Regular atrial cardiac myocyte", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0229538", "l": "Pituitary thyrotropic cell", "d": []}, {"i": "SNOMEDCT:33608007", "d": []}]}
{"type": "biolink:Cell", "ic": "89.347505587204751", "identifiers": [{"i": "CL:0002257", "l": "epithelial cell of thyroid gland", "d": ["An epithelial cell of thyroid gland."]}]}
{"type": "biolink:Cell", "ic": "87.120474278337809", "identifiers": [{"i": "UMLS:C1514202", "l": "Polygonal Brown Fat Cell", "d": []}, {"i": "NCIT:C36967", "l": "Polygonal Brown Fat Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C4725911", "l": "Autologous Anti-CD19 CAR-CD3zeta-4-1BB-expressing T-cells", "d": []}, {"i": "NCIT:C150671", "l": "Autologous Anti-CD19 CAR-CD3zeta-4-1BB-expressing T-cells", "d": ["A preparation of autologous T-lymphocytes that are engineered to express a chimeric antigen receptor (CAR) composed of an anti-cluster of differentiation 19 (CD19) single chain variable fragment (scFv) linked to the intracellular signaling domains of 4-1BB (CD137) and the zeta chain of the TCR/CD3 complex (TCRzeta; CD247; CD3zeta), with potential immunomodulating and antineoplastic activities. Upon administration of the autologous anti-CD19 CAR-CD3zeta-4-1BB-expressing T-cells, these cells target, bind to and induce selective toxicity in CD19-expressing tumor cells. CD19 antigen is a B-cell specific cell surface antigen expressed in all B-cell lineage malignancies."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0228009", "l": "Secondary spermatocyte", "d": []}, {"i": "SNOMEDCT:3374006", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5174098", "l": "Myelocytes | Cerebral spinal fluid | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1440276", "l": "Cells.CD27", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4253015", "l": "Set of type D cells of pancreatic islet", "d": []}]}
{"type": "biolink:Cell", "ic": "75.105493098994543", "identifiers": [{"i": "CL:0000912", "l": "helper T cell", "d": ["A effector T cell that provides help in the form of secreted cytokines to other immune cells."]}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "CL:0002544", "l": "aortic endothelial cell", "d": ["An arterial endothelial cell that is part of the aorta endothelium."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0003028", "l": "M1 retinal ganglion cell", "d": ["A monostratified retinal ganglion cell that has a small dendrite field with a dense dendrite arbor with post synaptic terminals in sublaminer layer S4."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1440388", "l": "Cells.G2+M phase", "d": []}]}
{"type": "biolink:Cell", "ic": "75.26123597683771", "identifiers": [{"i": "UMLS:C1708869", "l": "Malignant Cuboidal Mucous Cell", "d": []}, {"i": "NCIT:C47811", "l": "Malignant Cuboidal Mucous Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C3273204", "l": "MAGE-A3 Reactive T Cell Receptor-transduced Autologous T Cells", "d": []}, {"i": "NCIT:C97035", "l": "MAGE-A3 Reactive T Cell Receptor-transduced Autologous T Cells", "d": ["Human autologous T-lymphocytes transduced with a retroviral vector encoding a T cell receptor (TCR) specific for the human melanoma antigen A3 (MAGE-A3), with potential antineoplastic activity. Upon isolation, transduction, expansion ex vivo, and reintroduction into the patient, the MAGE-A3 reactive TCR-transduced autologous T cells bind to tumor cells expressing MAGE-A3, which may halt the growth of MAGE-A3-expressing cancer cells; the TCR is specific for MAGE-A3:168-176."]}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "CL:0008036", "l": "extravillous trophoblast", "d": ["A trophoblast cell that is not part of a placental villous."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "MESH:D065309", "l": "Atypical Squamous Cells of the Cervix", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0017004", "l": "telocyte", "d": ["A supportive cell with a small, oval-shaped body and one to five telopodes. Telopodes are cytoplasmic protrusions from tens to hundreds of micrometers long and mostly below 0.2 microns of caliber."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0011021", "l": "fibroblast of upper back skin", "d": ["A fibroblast that is part of upper back skin."]}]}
{"type": "biolink:Cell", "ic": "77.271239091128209", "identifiers": [{"i": "UMLS:C1518224", "l": "Malignant Neuroendocrine Spindle Cell", "d": []}, {"i": "NCIT:C36854", "l": "Malignant Neuroendocrine Spindle Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "90.82444074280258", "identifiers": [{"i": "UMLS:C1513068", "l": "Medium-Sized Neoplastic Myeloblast with Coarse Cytoplasmic Basophilic Granules", "d": []}, {"i": "NCIT:C37180", "l": "Medium-Sized Neoplastic Myeloblast with Coarse Cytoplasmic Basophilic Granules", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1277042", "l": "Parathyroid cell", "d": []}, {"i": "SNOMEDCT:360553006", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0000591", "l": "warmth sensing thermoreceptor cell", "d": ["A thermoreceptor cell that detects increased temperatures."]}]}
{"type": "biolink:Cell", "ic": "83.552982069901191", "identifiers": [{"i": "CL:0002038", "l": "T follicular helper cell", "d": ["A CD4-positive, CXCR5-positive, CCR7-negative alpha-beta T cell located in follicles of secondary lymph nodes that is BCL6-high, ICOS-high and PD1-high, and stimulates follicular B cells to undergo class-switching and antibody production."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2599947", "l": "Purkinje cell cytoplasmic type 1", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5382812", "l": "Cytomegalovirus-specific CD8 cells | Blood | Cell markers", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0003015", "l": "G11-ON retinal ganglion cell", "d": ["A G11 retinal ganglion cell that has post synaptic terminals in sublaminar layer S4 and is depolarized by illumination of its receptive field center."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0013921", "l": "Tumor Cells, Embolic", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1708270", "l": "Ex Vivo-Expanded HER2-Specific T Cells", "d": []}, {"i": "NCIT:C52192", "l": "Ex Vivo-Expanded HER2-Specific T Cells", "d": ["T cells specific for the human epidermal growth factor receptor 2 (HER2) with potential immunopotentiating activity. T cells directed against HER2, overexpressed on many tumor cells, are collected from HER2-expressing tumor tissue, expanded ex vivo and, then re-introduced in the patient. Re-introduction of ex vivo-expanded HER2-specific T cells may enhance the cytotoxic T cell response against tumor cells overexpressing HER2, resulting in inhibition of tumor growth."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157493", "l": "CD34 cells | Blood | Cell markers", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0017009", "l": "Axl+ dendritic cell, human", "d": ["A human dendritic cell that expresses the AXL and SIGLEC6 genes."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157463", "l": "CD3+CD8+CD57+ cells | Blood | Cell markers", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2340500", "l": "Microfold cell of epithelium of intestinal villus", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5381001", "l": "Cells.CD8.HLA-B7 CMV specific", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1518630", "l": "Mouse Osteoclast", "d": []}, {"i": "NCIT:C22681", "l": "Mouse Osteoclast", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2339402", "l": "Supporting cell of cochlea", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0483186", "l": "CD19+SmIg kappa+", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5706216", "l": "Antigen-Presenting Cancer-Associated Fibroblast", "d": []}, {"i": "NCIT:C187401", "l": "Antigen-Presenting Cancer-Associated Fibroblast", "d": ["A cancer-associated fibroblast characterized by novel expression of major histocompatibility complex class II molecules, which are capable of antigen presentation. These cells may mediate immune evasion."]}]}
{"type": "biolink:Cell", "ic": "87.120474278337809", "identifiers": [{"i": "CL:4023121", "l": "sst chodl GABAergic cortical interneuron", "d": ["A sst GABAergic cortical interneuron that also expresses Chodl. These neurons are rare and correspond to the only known cortical interneurons with long-range projection."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1441344", "l": "100 lymphocytes.small", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C0312738", "l": "Pre-B Lymphocytes", "d": []}, {"i": "NCIT:C33391", "l": "Pre-B Lymphocyte", "d": []}, {"i": "SNOMEDCT:25841003", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157235", "l": "CD10 blasts | Bone marrow | Cell markers", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2325162", "l": "Primary afferent neuron", "d": []}]}
{"type": "biolink:Cell", "ic": "79.849015605436421", "identifiers": [{"i": "CL:0019018", "l": "blood vessel smooth muscle cell", "d": ["A smooth muscle cell that is part of any blood vessel."]}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "CL:2000045", "l": "foreskin melanocyte", "d": ["Any melanocyte that is part of a prepuce of penis."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0000597", "l": "microconidium", "d": ["The smaller of two types of asexual spores formed by some fungi. An ovoid to pear-shaped asexual spore that contains very little cytoplasm and organelles, is uninucleate, and forms in vegetative hypae within a mycelium. Micronidia are extruded from the hyphal cell wall."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0009078", "l": "thymic fibroblast type 1", "d": ["A fibroblast located in the thymic capsule."]}]}
{"type": "biolink:Cell", "ic": "74.659114980698789", "identifiers": [{"i": "CL:2000005", "l": "brain macroglial cell", "d": ["Any macroglial cell that is part of a brain."]}]}
{"type": "biolink:Cell", "ic": "79.541110464886842", "identifiers": [{"i": "CL:0000843", "l": "follicular B cell", "d": ["A resting mature B cell that has the phenotype IgM-positive, IgD-positive, CD23-positive and CD21-positive, and found in the B cell follicles of the white pulp of the spleen or the corticol areas of the peripheral lymph nodes. This cell type is also described as being CD19-positive, B220-positive, AA4-negative, CD43-negative, and CD5-negative."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4263663", "l": "B-cell CD27 & IgD subsets", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5205410", "l": "Allogeneic CD34-positive Enriched Peripheral Blood Stem Cells", "d": []}, {"i": "NCIT:C160626", "l": "Allogeneic CD34-positive Enriched Peripheral Blood Stem Cells", "d": ["A preparation of allogeneic CD34+ selected peripheral blood stem cells (PBSCs) that can potentially be used for immune reconstitution purposes. Upon administration of the allogeneic CD34-positive enriched PBSCs after a hematopoietic cell transplantation (HCT), these cells may provide memory T-cell (Tm) recovery and potentially prevent viral infections. They potentially reduce the occurrence of graft-versus-host disease (GvHD) without increasing the risk of graft failure or poor graft function."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1267962", "l": "Lymphocyte positive for CD66E antigen", "d": []}, {"i": "SNOMEDCT:117403001", "d": []}]}
{"type": "biolink:Cell", "ic": "90.82444074280258", "identifiers": [{"i": "CL:0000952", "l": "preBCR-positive large pre-B-II cell", "d": ["An preBRC-positive large pre-B-II cell is a large pre-B-II cell that is pre-B cell receptor-positive, composed of surrogate light chain protein (SL), which is composed of VpreB , Lambda 5/14.1, in complex with immunoglobulin mu heavy chain (IgHmu) on the cell surface."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5440683", "l": "Breyanzi", "d": []}]}
{"type": "biolink:Cell", "ic": "88.140761698499901", "identifiers": [{"i": "UMLS:C1514165", "l": "Pleomorphic Adenocarcinoma Cell", "d": []}, {"i": "NCIT:C37171", "l": "Pleomorphic Adenocarcinoma Cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4722512", "l": "BPX-501", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5171666", "l": "Lymphocytes | Semen | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "CL:4023048", "l": "L4/5 intratelencephalic projecting glutamatergic neuron of the primary motor cortex", "d": ["An intratelencephalic-projecting glutamatergic with a soma located in upper L5 of the primary motor cortex. These cells have thin untufted apical dendrites."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5216236", "l": "Leukocytes|NCnc|Pt|Gast fld", "d": []}]}
{"type": "biolink:Cell", "ic": "90.82444074280258", "identifiers": [{"i": "CL:0002481", "l": "peritubular myoid cell", "d": ["The flattened smooth myoepithelial cells of mesodermal origin that lie just outside the basal lamina of the seminiferous tubule."]}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "CL:0000936", "l": "early lymphoid progenitor", "d": ["A lymphoid progenitor cell that is found in bone marrow, gives rise to B cells, T cells, natural killer cells and dendritic cells, and has the phenotype Lin-negative, Kit-positive, Sca-1-positive, FLT3-positive, CD34-positive, CD150 negative, and GlyA-negative."]}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "CL:0003049", "l": "M cone cell", "d": ["A cone cell that detects medium wavelength light. Exact peak of spectra detected differs between species. In humans, spectra peaks at 534-545 nm."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4324222", "l": "CD16+CD57+NK lymphocyte", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5216295", "l": "Neutrophils|NCnc|Pt|Plr fld", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C0598170", "l": "Melanoblast", "d": []}, {"i": "NCIT:C85503", "l": "Melanoblast", "d": ["An immature precursor cell that gives rise to a melanocyte."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C2981832", "l": "HER2Bi-Armed Activated T Cells", "d": []}, {"i": "NCIT:C88317", "l": "HER2Bi-Armed Activated T Cells", "d": ["Activated T cells (ATC) that have been coated with bispecific antibodies (BiAb), with potential antineoplastic and immunomodulating activities. In vitro, T cells are activated through exposure to the anti-CD3 murine monoclonal antibody OKT3 and interleukin 2 for 14 days and then armed with anti-CD3 x anti-Her2 bispecific antibody (Her2Bi). Upon administration, HER2Bi-armed activated T cells attach to CD3-expressing T cells and HER2/neu-expressing tumor cells, selectively cross-linking T cells and tumor cells; this may result in the recruitment and activation of cytotoxic T lymphocyte (CTLs), CTL perforin-mediated tumor cell cytolysis, and the secretion of antitumor cytokines and chemokines."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0596568", "l": "fiber cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157348", "l": "CD19 cells | XXX | Cell markers", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C3900007", "l": "Autologous 4-1BB Selected Tumor Infiltrating Lymphocytes", "d": []}, {"i": "NCIT:C119703", "l": "Autologous 4-1BB Selected Tumor Infiltrating Lymphocytes", "d": ["A preparation of autologous tumor infiltrating lymphocytes (TILs) expressing the co-stimulatory signaling domain 4-1BB (CD137), with potential antineoplastic activity. TILs are isolated from a patient's tumor and those expressing 4-1BB are selected for expansion in vitro. Upon re-infusion into the patient, the 4-1BB-expressing TILs re-infiltrate the tumor to initiate tumor cell lysis. 4-1BB, a member of the tumor necrosis factor (TNF) receptor superfamily, enhances TIL survival and antitumor cytolytic activity."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2333471", "l": "Set of adrenergic cells", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1182628", "l": "Epithelial cell of anterior palatal part of viscerocranial mucosa", "d": []}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "UMLS:C1883044", "l": "Small Adenocarcinoma Cell with Scant Amount of Cytoplasm", "d": []}, {"i": "NCIT:C61144", "l": "Small Adenocarcinoma Cell with Scant Amount of Cytoplasm", "d": []}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "CL:0002199", "l": "oxyphil cell of parathyroid gland", "d": ["An oncocyte located in the parathyroid gland."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4724904", "l": "Allogeneic iC9/CAR19/IL15-transduced CB-NK Cells", "d": []}]}
{"type": "biolink:Cell", "ic": "77.944915021140389", "identifiers": [{"i": "CL:0000784", "l": "plasmacytoid dendritic cell", "d": ["A dendritic cell type of distinct morphology, localization, and surface marker expression (CD123-positive) from other dendritic cell types and associated with early stage immune responses, particularly the release of physiologically abundant amounts of type I interferons in response to infection."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5178285", "l": "Prolymphocytes | Body fluid | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0000360", "l": "morula cell", "d": ["A cell of the early embryo at the developmental stage in which the blastomeres, resulting from repeated mitotic divisions of the fertilized ovum (zygote), form a compact cell mass."]}]}
{"type": "biolink:Cell", "ic": "55.830996171171918", "identifiers": [{"i": "CL:0008019", "l": "mesenchymal cell", "d": ["A non-polarised cell precursor cell that is part of some mesenchyme, is associated with the cell matrix but is not connected to other cells and is capable of migration."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5175645", "l": "Oval macrocytes | Blood | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "UMLS:C1512945", "l": "Intraepithelial T-Lymphocyte of the Intestine", "d": []}, {"i": "NCIT:C39613", "l": "Intraepithelial T-Lymphocyte of the Intestine", "d": ["A mature T lymphocyte, found in the intestinal lining that differentiates from its precursor outside the thymus, most likely in an area of the gut identified as cryptopatch aggregates. This cell plays a key role in cell-mediated mucosal defense, the down-regulation of immune responses to harmless luminal antigens and in epithelial cell growth and repair."]}]}
{"type": "biolink:Cell", "ic": "71.079643100360357", "identifiers": [{"i": "CL:4030031", "l": "interstitial cell", "d": ["Any cell that is located within the interstitium between the cells most prominent in defining a given tissue. \"Interstitial cell\" is a morphological term and refers to a variety of cells with differing origins and phenotypes."]}]}
{"type": "biolink:Cell", "ic": "90.82444074280258", "identifiers": [{"i": "UMLS:C1511184", "l": "Bizarre Cell with Evidence of Skeletal Muscle Differentiation", "d": []}, {"i": "NCIT:C36953", "l": "Bizarre Cell with Evidence of Skeletal Muscle Differentiation", "d": []}]}
{"type": "biolink:Cell", "ic": "68.042516761614237", "identifiers": [{"i": "CL:0000036", "l": "epithelial fate stem cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1182658", "l": "Myoepithelial cell of dilator pupillae", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2709135", "l": "Frozen erythrocytes pediatric units", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002396", "l": "CD14-low, CD16-positive monocyte", "d": ["A patrolling monocyte that is CD14-low and CD16-positive."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0229648", "l": "Nonsegmented basophil", "d": []}, {"i": "SNOMEDCT:3383001", "d": []}]}
{"type": "biolink:Cell", "ic": "90.82444074280258", "identifiers": [{"i": "UMLS:C1513754", "l": "Multivacuolated Brown Fat Cell", "d": []}, {"i": "NCIT:C36968", "l": "Multivacuolated Brown Fat Cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5213934", "l": "Plasma cells monotypic population | Bone marrow | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1267904", "l": "Lymphocyte positive for CD31 antigen", "d": []}, {"i": "SNOMEDCT:117575006", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1267864", "l": "Lymphocyte positive for CD11 antigen", "d": []}, {"i": "SNOMEDCT:117545001", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2332129", "l": "Internodal tract myocyte", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1979643", "l": "Blasts.CD3+CD16+CD56+", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1267868", "l": "Lymphocyte positive for CD11C antigen", "d": []}, {"i": "SNOMEDCT:116849005", "d": []}]}
{"type": "biolink:Cell", "ic": "73.597844352697123", "identifiers": [{"i": "CL:0000038", "l": "erythroid progenitor cell", "d": ["A progenitor cell committed to the erythroid lineage."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4700206", "l": "Cells.CD25+CD45RA+CD127Low+", "d": []}]}
{"type": "biolink:Cell", "ic": "92.728541327098611", "identifiers": [{"i": "UMLS:C1708890", "l": "Malignant Neuroectodermal Cell with Hyperchromatic Nucleus and Scanty Cytoplasm", "d": []}, {"i": "NCIT:C54040", "l": "Malignant Neuroectodermal Cell with Hyperchromatic Nucleus and Scanty Cytoplasm", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0034083", "l": "Pulmonary Stretch Receptors", "d": []}, {"i": "MESH:D011661", "l": "Pulmonary Stretch Receptors", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0882903", "l": "Cell positive for CD56 antigen", "d": []}, {"i": "SNOMEDCT:116828009", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1440275", "l": "Cells.CD26", "d": []}]}
{"type": "biolink:Cell", "ic": "90.82444074280258", "identifiers": [{"i": "CL:0001070", "l": "beige adipocyte", "d": ["A fat cell that is beige in color, thermogenic, and which differentiates in white fat tissue from a Myf5-negative progenitor."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:4030055", "l": "intermediate cell of urothelium", "d": ["A urothelial cell that is part of the regenerative layer(s) of cells directly superficial to basal cells in urothelium. The layer of intermediate cells in the urothelium ranges from one to several layers thick depending on the species with intermediate cells attached to adjacent cell layers and one another via desmosomes."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1184140", "l": "Myoepithelial cell of tertiary lactiferous duct", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157532", "l": "CD4 cells | Blood | Cell markers", "d": []}]}
{"type": "biolink:Cell", "ic": "71.786315444102826", "identifiers": [{"i": "CL:0002522", "l": "renal filtration cell", "d": ["A renal filtration cell is a specialized cell of the renal system that filter fluids by charge, size or both."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5418087", "l": "Autologous Rapamycin-resistant Th1/Tc1 Cells RAPA-201", "d": []}, {"i": "NCIT:C174405", "l": "Autologous Rapamycin-resistant Th1/Tc1 Cells RAPA-201", "d": ["A preparation of autologous rapamycin-resistant Th1/Tc1 cells, with potential immunomodulating activity. Upon administration, autologous rapamycin-resistant Th1/Tc1 cells RAPA-201 may recognize and kill tumor cells. Ex-vivo induction of rapamycin-resistance may increase the persistence of T-cells after adoptive transfer."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1253961", "l": "Colligocyte", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5417957", "l": "Anti-HER2 Antibody Conjugated Natural Killer Cells ACE1702", "d": []}]}
{"type": "biolink:Cell", "ic": "87.120474278337809", "identifiers": [{"i": "UMLS:C1514057", "l": "Neoplastic Perineurial Cell", "d": []}, {"i": "NCIT:C37154", "l": "Neoplastic Perineurial Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "61.537412234791987", "identifiers": [{"i": "CL:0008000", "l": "non-striated muscle cell", "d": ["Any muscle cell in which the fibers are not organised into sarcomeres."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0599819", "l": "PBL (peripheral blood lymphocyte)", "d": []}]}
{"type": "biolink:Cell", "ic": "78.185623981295834", "identifiers": [{"i": "CL:0000129", "l": "microglial cell", "d": ["A central nervous system macrophage found in the parenchyma of the central nervous system. Marker include CD11b-positive, F4/80-positive, and CD68-positive."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C3898190", "l": "NY-ESO-1-specific CD4-positive T Lymphocytes", "d": []}, {"i": "NCIT:C117724", "l": "NY-ESO-1-specific CD4-positive T Lymphocytes", "d": ["A preparation of autologous CD4+ T-lymphocytes sensitized to cancer-testis antigen NY-ESO-1, with potential immunostimulating and antineoplastic activities. CD4-positive T-lymphocytes are exposed to a NY-ESO-1 peptide ex vivo, expanded, and introduced into the patient. The NY-ESO-1-specific CD4-positive T-lymphocytes may stimulate the host immune system to produce a cytotoxic T-lymphocyte (CTL) response against tumor cells expressing the NY-ESO-1 antigen, which results in tumor cell lysis. NY-ESO-1, an antigen found in normal testis, may be upregulated in various cancers."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C3641687", "l": "MCPyV TAg-specific Polyclonal Autologous CD8-positive T Cells", "d": []}, {"i": "NCIT:C104009", "l": "MCPyV TAg-specific Polyclonal Autologous CD8-positive T Cells", "d": ["A preparation of polyclonal autologous CD8 positive T-lymphocytes specific for the Merkel cell polyomavirus (MCPyV) T antigen (TAg) with potential antineoplastic activity. Peripheral blood lymphocytes from a Merkel cell carcinoma (MCC) patient were obtained and antigen-specific CD8+ T cells targeting a specific MCPyV TAg epitope were derived and expanded ex vivo. Upon infusion of the MCPyV TAg-specific polyclonal autologous CD8-positive T cell vaccine, the T cells recognize the MCPyV antigen and exert a cytotoxic T-lymphocyte response against the MCPyV TAg-expressing MCC cells. MCPyV is expressed in about 80% of MCC and is not expressed in normal, human tissue; the MCPyVTag oncoprotein plays a key role in MCC survival and tumor cell proliferation."]}]}
{"type": "biolink:Cell", "ic": "64.998193119084064", "identifiers": [{"i": "UMLS:C1513925", "l": "Neoplastic Astrocyte", "d": []}, {"i": "NCIT:C37127", "l": "Neoplastic Astrocyte", "d": []}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "CL:1001586", "l": "mammary gland glandular cell", "d": ["Glandular cell of mammary epithelium. Example: glandular cells of large and intermediate ducts, glandular cells in terminal ducts."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0008048", "l": "upper motor neuron", "d": ["A glutamatergic motor neuron with a soma in the brainstem or cerebral cortex.  They do not synapse directly to muscles but rather to lower motor neurons, which do.  They are the main controllers of voluntary movement."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1277065", "l": "Entire interstitial cell of Leydig", "d": []}, {"i": "SNOMEDCT:367715001", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C4763553", "l": "Allogeneic CMV Antigen-specific CD4+/CD8+ T-lymphocytes", "d": []}, {"i": "NCIT:C157340", "l": "Allogeneic CMV Antigen-specific CD4+/CD8+ T-lymphocytes", "d": ["A population of allogeneic T-lymphocytes specifically reactive to cytomegalovirus (CMV) with potential antiviral activity. Allogeneic CMV antigen-specific T-cells are prepared via ex vivo stimulation of donor-derived peripheral blood mononuclear cells (PBMCs) with major cytomegalovirus structural protein, pp65 (ppUL83). T-cells that secrete interferon (IFN)-gamma in response to pp65 antigen exposure are selected and expanded for administration. Administration of the CMV antigen-specific CD4+ and CD8+T-lymphocytes into hematopoietic stem cell transplant (HSCT) or immunocompromised patients infected with CMV may potentially reconstitute virus-specific responses, thereby controlling CMV infections."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:4030050", "l": "D1/D2-hybrid medium spiny neuron", "d": ["A medium spiny neuron that expresses both DRD1 and DRD2 and is part of an extra-striosomal part of dorsal striatum."]}]}
{"type": "biolink:Cell", "ic": "74.804588241401973", "identifiers": [{"i": "CL:0000387", "l": "hemocyte (sensu Arthropoda)", "d": ["A blood cell of the circulatory system of arthropods."]}]}
{"type": "biolink:Cell", "ic": "59.505740659167984", "identifiers": [{"i": "CL:0000015", "l": "male germ cell", "d": ["A germ cell that supports male gamete production. In some species, non-germ cells known as Sertoli cells also play a role in spermatogenesis."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5556648", "l": "Autologous Anti-CD19 CAR Vector-transduced T Cells pCAR-19B", "d": []}, {"i": "NCIT:C180824", "l": "Autologous Anti-CD19 CAR Vector-transduced T Cells pCAR-19B", "d": ["A preparation of autologous T-lymphocytes that have been genetically modified and transduced with a vector encoding a chimeric antigen receptor (CAR) specific for the tumor-associated antigen (TAA) cluster of differentiation (CD) 19, with potential immunostimulating and antineoplastic activities. Upon administration, autologous anti-CD19 CAR vector-transduced T-cells pCAR-19B specifically recognize and kill CD19-expressing tumor cells. CD19 antigen is a B-cell specific cell surface antigen expressed in all B-cell lineage malignancies."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5447428", "l": "Autologous Anti-CD20 CAR T-cells C-CAR066", "d": []}, {"i": "NCIT:C176772", "l": "Autologous Anti-CD20 CAR T-cells C-CAR066", "d": ["A preparation of autologous T-lymphocytes that have been genetically modified to express a chimeric antigen receptor (CAR) targeting the tumor-associated antigen (TAA) cluster of differentiation 20 (CD20), with potential immunostimulating and antineoplastic activities. Upon administration, C-CAR066 specifically recognize and kill CD20-expressing tumor cells. The CD20 antigen, a non-glycosylated cell surface phosphoprotein, is a B-cell specific cell surface antigen expressed in B-cell lineage malignancies and certain melanoma cell subpopulations."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2328733", "l": "Pseudo-unipolar neuron", "d": []}]}
{"type": "biolink:Cell", "ic": "38.588613167111681", "identifiers": [{"i": "UMLS:C0334227", "l": "Tumor cells, malignant", "d": []}, {"i": "NCIT:C12917", "l": "Malignant Cell", "d": ["Cells of, or derived from, a malignant tumor."]}, {"i": "SNOMEDCT:88400008", "d": []}]}
{"type": "biolink:Cell", "ic": "81.648881485605159", "identifiers": [{"i": "CL:0001061", "l": "abnormal cell", "d": ["A cell found in an organism or derived from an organism exhibiting a phenotype that deviates from the expected phenotype of any native cell type of that organism. Abnormal cells are typically found in disease states or disease models."]}]}
{"type": "biolink:Cell", "ic": "60.360460295495969", "identifiers": [{"i": "CL:0000473", "l": "defensive cell", "d": ["A cell whose primary function is to protect the organism."]}]}
{"type": "biolink:Cell", "ic": "87.120474278337809", "identifiers": [{"i": "CL:0000871", "l": "splenic macrophage", "d": ["A secondary lymphoid organ macrophage found in the spleen."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:2000085", "l": "mononuclear cell of umbilical cord", "d": ["Any mononuclear cell that is part of a umbilical cord."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1524046", "l": "CNS - Brain - Neuron (MMHCC)", "d": []}, {"i": "NCIT:C22618", "l": "Mouse Brain Neuron", "d": []}]}
{"type": "biolink:Cell", "ic": "77.271239091128209", "identifiers": [{"i": "UMLS:C1518221", "l": "Malignant Neuroendocrine Polygonal Cell", "d": []}, {"i": "NCIT:C36855", "l": "Malignant Neuroendocrine Polygonal Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:1000365", "l": "transitional myocyte of atrial septal branch of anterior internodal tract", "d": ["A transitional myocyte that is part of the atrial septal branch of anterior internodal tract."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:1001209", "l": "inner medulla vasa recta ascending limb cell", "d": []}]}
{"type": "biolink:Cell", "ic": "54.874368555193477", "identifiers": [{"i": "UMLS:C0017526", "l": "Giant Cells", "d": []}, {"i": "NCIT:C12607", "l": "Giant Cell", "d": ["An abnormally large cell that contains multiple nuclei and an abundant amount of cytoplasm."]}, {"i": "MESH:D015726", "l": "Giant Cells", "d": []}, {"i": "SNOMEDCT:60401004", "d": []}, {"i": "SNOMEDCT:81480003", "d": []}]}
{"type": "biolink:Cell", "ic": "81.247621244257502", "identifiers": [{"i": "CL:0002040", "l": "immature NK T cell stage II", "d": ["A CD24-low, CD44-negative, NK1.1-negative NK T cell."]}]}
{"type": "biolink:Cell", "ic": "79.849015605436421", "identifiers": [{"i": "UMLS:C5706882", "l": "PIT1-Lineage Adenohypophysial Cell", "d": []}, {"i": "NCIT:C187077", "l": "PIT1-Lineage Adenohypophysial Cell", "d": ["An adenohypophysial cell determined by the expression of pituitary specific transcription factor 1."]}]}
{"type": "biolink:Cell", "ic": "80.511444690059548", "identifiers": [{"i": "CL:0000511", "l": "androgen binding protein secreting cell", "d": ["A peptide hormone secreting cell that secretes androgen binding protein."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4745265", "l": "Allogeneic UCB-derived HSPCs MGTA 456", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:4028004", "l": "alveolar type 1 fibroblast cell", "d": ["A pulmonary interstitial fibroblast that is part of the alveolus and contains lipid droplets."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157238", "l": "CD10+CD19+ cells | Blood | Cell markers", "d": []}]}
{"type": "biolink:Cell", "ic": "84.75972595860604", "identifiers": [{"i": "UMLS:C1520165", "l": "Xanthomatous Astrocyte", "d": []}, {"i": "NCIT:C37139", "l": "Xanthomatous Astrocyte", "d": []}]}
{"type": "biolink:Cell", "ic": "80.511444690059548", "identifiers": [{"i": "CL:0002308", "l": "epithelial cell of skin gland", "d": ["An epithelial cell of a skin gland."]}]}
{"type": "biolink:Cell", "ic": "92.728541327098611", "identifiers": [{"i": "UMLS:C1513528", "l": "Mouse Cell Line", "d": []}, {"i": "NCIT:C20220", "l": "Mouse Cell Line", "d": []}]}
{"type": "biolink:Cell", "ic": "69.453592996529309", "identifiers": [{"i": "CL:0000513", "l": "cardiac muscle myoblast", "d": ["A precursor cell destined to differentiate into cardiac muscle cell."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2951083", "l": "Set of interneurons of gray matter of spinal cord", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1267923", "l": "Lymphocyte positive for CD42C antigen", "d": []}, {"i": "SNOMEDCT:117367004", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1267890", "l": "Lymphocyte positive for CD20 antigen", "d": []}, {"i": "SNOMEDCT:116842001", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002155", "l": "echinocyte", "d": ["A crenated erythrocyte with 30+ crenations, bumps or spurs that are the result of damage due to age or disease."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5554927", "l": "Autologous Anti-HER2 TAC T Cells TAC01-HER2", "d": []}, {"i": "NCIT:C178298", "l": "Autologous Anti-HER2 TAC T Cells TAC01-HER2", "d": ["A preparation of autologous T-lymphocytes that are genetically engineered with a T cell Antigen Coupler (TAC), comprising of a domain that targets the tumor-associated antigen (TAA) human epidermal growth factor receptor 2 (HER2) and another domain that binds to the endogenous T cell receptor (TCR), with potential immunostimulating and antineoplastic activities. Upon administration, autologous anti-HER2 TAC  T cells TAC01-HER2 targets and binds to HER2-expressing tumor cells and activates TCR-mediated signaling pathways, leading to T cell-mediated killing of HER2-expressing tumor cells. HER-2, a tyrosine kinase receptor for epidermal growth factor (EGF) (also known as neu and ErbB2), is overexpressed by a variety of cancers."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5170921", "l": "Leukocytes | Bone marrow | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "ic": "70.441195081532641", "identifiers": [{"i": "CL:0000798", "l": "gamma-delta T cell", "d": ["A T cell that expresses a gamma-delta T cell receptor complex."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5571781", "l": "Siderocytes.Type 3", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C3496569", "l": "A12 dopamine cells", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5206608", "l": "Autologous BCMA-targeted CAR T Cells LCAR-B4822M", "d": []}, {"i": "NCIT:C162506", "l": "Autologous BCMA-targeted CAR T Cells LCAR-B4822M", "d": ["A preparation of autologous peripheral blood T-lymphocytes (PBTLs) that have been genetically modified to express a chimeric antigen receptor (CAR) specific for the B-cell maturation antigen (BCMA; tumor necrosis factor receptor superfamily member 17; TNFRSF17), with potential immunostimulating and antineoplastic activities. Upon administration, autologous BCMA-targeted CAR T-cells LCAR-B4822M specifically recognize and kill BCMA-expressing tumor cells. BCMA, a tumor specific antigen and a receptor for both a proliferation-inducing ligand (APRIL) and B-cell activating factor (BAFF), is a member of the tumor necrosis factor (TNF) receptor superfamily and plays a key role in plasma cell survival; it is found on the surfaces of plasma cells and overexpressed on malignant plasma cells."]}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "CL:0002408", "l": "immature Vgamma2-negative thymocyte", "d": ["A double negative post-natal thymocyte that has a T cell receptor consisting of a gamma chain that does not contain a Vgamma2 segment, and a delta chain. This cell type is CD4-negative, CD8-negative and CD24-positive."]}]}
{"type": "biolink:Cell", "ic": "88.140761698499901", "identifiers": [{"i": "CL:0000776", "l": "immature neutrophil", "d": ["Any of the immature forms of a neutrophil in which neutrophilic specific granules are present but other phenotypic features of the mature form may be lacking."]}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "UMLS:C1513991", "l": "Neoplastic Interdigitating Dendritic Cell", "d": []}, {"i": "NCIT:C36892", "l": "Neoplastic Interdigitating Dendritic Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5555352", "l": "Peripheral Blood Mononuclear Cell Sample", "d": []}, {"i": "NCIT:C178965", "l": "Peripheral Blood Mononuclear Cell Sample", "d": ["A sample of peripheral blood mononuclear cells."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002103", "l": "IgG-positive double negative memory B cell", "d": ["An IgG-positive double negative memory B cell is a double negative memory B cell with the phenotype IgG-positive, IgD-negative, and CD27-negative."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2936408", "l": "Mesophyll Cells", "d": []}, {"i": "MESH:D058503", "l": "Mesophyll Cells", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1181540", "l": "Chromaffin cell of paraganglion", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5216233", "l": "Leukocytes|NCnc|Pt|Bronchial", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5419630", "l": "LMP2-specific T Cell Receptor-transduced Autologous T-lymphocytes", "d": []}, {"i": "NCIT:C172395", "l": "LMP2-specific T Cell Receptor-transduced Autologous T-lymphocytes", "d": ["A preparation of autologous T-lymphocytes that have been transduced with a lentiviral vector encoding a T-cell receptor (TCR) specific for human leukocyte antigen (HLA)-A02:01/24:02/11:01-restricted Epstein-Barr virus (EBV) latent membrane proteins (LMP) 1 and 2, and EBV nuclear antigen 1 (EBNA1), with potential antineoplastic activity. Upon administration, the autologous LMP1/LMP2/EBNA1-specific, HLA-A02:01/24:02/11:01-restricted TCR-expressing T-lymphocytes YT-E001 recognize and bind to HLA-presented EBV peptides, which may promote cell death and inhibit the growth of tumor cells expressing LMP1, LMP2 or EBNA1. LMP1, LMP2, and EBNA1 are expressed in various, EBV-associated malignancies, including nasopharyngeal cancer and EBV-positive Hodgkin lymphoma."]}]}
{"type": "biolink:Cell", "ic": "90.82444074280258", "identifiers": [{"i": "CL:0000965", "l": "Bm3 B cell", "d": ["A germinal center B cell that is rapidly dividing and has the phenotype IgD-negative, CD38-positive, and CD77-positive. Somatic hypermutation of the immunoglobulin V gene region can occur during proliferation of this cell type."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C2346933", "l": "Malignant Epithelioid Osteoblast", "d": []}, {"i": "NCIT:C67523", "l": "Malignant Epithelioid Osteoblast", "d": []}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "UMLS:C5204267", "l": "Renomedullary Interstitial Cell", "d": []}, {"i": "NCIT:C159218", "l": "Renomedullary Interstitial Cell", "d": ["A cell located in the inner renal medulla. It expresses receptors for vasoactive peptides."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1956121", "l": "Skin Dendritic Cells", "d": []}]}
{"type": "biolink:Cell", "ic": "90.82444074280258", "identifiers": [{"i": "CL:0000636", "l": "Mueller cell", "d": ["Astrocyte-like radial glial cell that extends vertically throughout the retina, with the nucleus are usually in the middle of the inner nuclear layer."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0546495", "l": "P.B. basophilic metamyelocyte", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C3498290", "l": "A6sc cell group", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5707292", "l": "Autologous IL-7-expanded HER2-specific CD4+ T-cells", "d": []}, {"i": "NCIT:C187686", "l": "Autologous IL-7-expanded HER2-specific CD4+ T-cells", "d": ["A preparation of autologous, interleukin-7 (IL-7)-expanded, human epidermal growth factor receptor 2 (EGFR2; HER2; ErbB2)-specific, cluster of differentiation 4 (CD4)-positive T-lymphocytes, with potential immunostimulating and antineoplastic activities. Autologous HER2-specific CD4+ T-cells are expanded ex vivo with IL-7. Upon reintroduction into the patient, the autologous IL-7-expanded HER2-specific CD4+ T-cells recognize and stimulate a T-cell-mediated immune response against HER2-expressing tumor cells. HER2, a receptor tyrosine kinase (RTK) mutated or overexpressed in many tumor cell types, plays a key role in tumor cell proliferation and tumor vascularization. IL-7 is a cytokine that promotes the proliferation and survival of T-cells."]}]}
{"type": "biolink:Cell", "ic": "92.728541327098611", "identifiers": [{"i": "CL:0000666", "l": "fenestrated cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1183209", "l": "Set of tympanic cells", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4697027", "l": "Cells.CD27-CD45RO+CD62L-CCR7-", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C3826997", "l": "Carboxylesterase-expressing Allogeneic Neural Stem Cells", "d": []}, {"i": "NCIT:C113657", "l": "Carboxylesterase-expressing Allogeneic Neural Stem Cells", "d": ["A preparation of allogeneic neural stem cells (NSC), derived from a human fetal cell line, that are adenovirally-transduced to express a modified form of the human enzyme carboxylesterase (CE) hCE1m6, with potential adjuvant activity. Upon intracranial administration, NSCs localize to tumor sites, due to their tumor-trophic nature, and transiently express hCE1m6. Intravenous co-administration of the prodrug irinotecan allows for the selective conversion by hCE1m6 to its active metabolite and topoisomerase I inhibitor, SN-38, in the vicinity of tumor sites. This leads to a local anti-neoplastic effect and causes reduced toxicity and increased therapeutic efficacy of irinotecan. Since NSCs freely cross the blood-brain barrier, these cells can also be intravenously administered to target brain tumor cells. hCE1m6 shows increased activity as compared to unmodified human CE."]}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "CL:1000245", "l": "posterior lateral line ganglion neuron", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5216323", "l": "Unidentified cells|NCnc|Pt|Periton fld", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5206827", "l": "Autologous Genetically-modified MAGE-A4 C1032 CD8alpha T Cells", "d": []}, {"i": "NCIT:C162804", "l": "Autologous Genetically-modified MAGE-A4 C1032 CD8alpha T Cells", "d": ["Autologous human T-lymphocytes transduced with a retroviral vector encoding a T-cell receptor (TCR) specific for the human melanoma antigen A4 (MAGE-A4) and the CD8alpha co-receptor, with potential immunostimulatory and antineoplastic activities. Upon leukapheresis, isolation, transduction, expansion ex vivo, and reintroduction into the patient, the autologous genetically-modified MAGE-A4 C1032 CD8alpha T-cells bind to tumor cells expressing MAGE-A4. This may result in both inhibition of growth and increased cell death of MAGE-A4-expressing tumor cells. The tumor-associated antigen MAGE-A4, a member of the MAGE-A family of cancer testis antigens, is overexpressed by a variety of cancer cell types. Co-expression of CD8alpha may broaden the immune response against tumors and increase antitumor activity by converting CD4+ helper T-cells into CD8+ cytotoxic T-cells."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157424", "l": "CD3 cells | Blood | Cell markers", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0933802", "l": "Smooth columnar cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157267", "l": "CD11a blasts | XXX | Cell markers", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5171670", "l": "Lymphocytes | Vitreous fluid | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5216196", "l": "Blasts|NCnc|Pt|Bld", "d": []}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "UMLS:C1513954", "l": "Neoplastic Adrenal Cortical Compact Cell", "d": []}, {"i": "NCIT:C36931", "l": "Neoplastic Adrenal Cortical Compact Cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1317333", "l": "Erythrocytes.lytic resistant", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4696702", "l": "Cells.CD19+CD21-", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0010002", "l": "epithelial cell of umbilical artery", "d": ["An epithelial cell that is part_of a umbilical artery."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1514655", "l": "RL07", "d": []}, {"i": "NCIT:C20289", "l": "RL07", "d": ["Provider: Reliance Life Sciences, Mumbai, India. No information from provider. This cell line meets the criteria for the use of human embryonic stem cells by federally funded researchers."]}]}
{"type": "biolink:Cell", "ic": "75.751739371353352", "identifiers": [{"i": "CL:0000149", "l": "visual pigment cell", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C4086350", "l": "GD2-CAR-expressing Autologous T-lymphocytes", "d": []}, {"i": "NCIT:C123820", "l": "GD2-CAR-expressing Autologous T-lymphocytes", "d": ["Genetically modified, autologous T-lymphocytes transduced with a retroviral vector encoding a 14g2a.zeta chimeric antigen receptor (CAR) directed against the disialoganglioside GD2, with potential immunomodulating and antineoplastic activities. Upon intravenous administration, the activated T-lymphocytes target the GD2 antigen on tumor cells and selectively kill those cells. The tumor-associated antigen GD2 is overexpressed on the surface of almost all tumors of neuroectodermal origin."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1979671", "l": "Cells.CD3-CD16+CD56+CD244+", "d": []}]}
{"type": "biolink:Cell", "ic": "71.88020023694385", "identifiers": [{"i": "CL:0000500", "l": "follicular epithelial cell", "d": ["An epithelial somatic cell associated with a maturing oocyte."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157450", "l": "CD3+CD56+ cells | Bone marrow | Cell markers", "d": []}]}
{"type": "biolink:Cell", "ic": "92.728541327098611", "identifiers": [{"i": "CL:0000353", "l": "blastoderm cell", "d": ["An undifferentiated cell produced by early cleavages of the fertilized egg (zygote)."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157550", "l": "CD4+CD45RO+ cells | Blood | Cell markers", "d": []}]}
{"type": "biolink:Cell", "ic": "86.236661114203869", "identifiers": [{"i": "UMLS:C1519317", "l": "Signet Ring Lipoblast", "d": []}, {"i": "NCIT:C36975", "l": "Signet Ring Lipoblast", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5177798", "l": "Polymorphonuclear cells/leukocytes | Peritoneal fluid | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "ic": "79.246894609297499", "identifiers": [{"i": "UMLS:C1708902", "l": "Malignant Polygonal Cell with Eosinophilic Cytoplasm", "d": []}, {"i": "NCIT:C53641", "l": "Malignant Polygonal Cell with Eosinophilic Cytoplasm", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1267866", "l": "Lymphocyte positive for CD11A antigen", "d": []}, {"i": "SNOMEDCT:117547009", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C3495544", "l": "A10 dopamine cells", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1518751", "l": "Mouse Ovarian Germ Cell", "d": []}, {"i": "NCIT:C22659", "l": "Mouse Ovarian Germ Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5237260", "l": "Anti-CD19 CAR T-cells XLCART001", "d": []}, {"i": "NCIT:C165551", "l": "Anti-CD19 CAR T-cells XLCART001", "d": ["A preparation of T-lymphocytes that have been genetically modified to express a chimeric antigen receptor (CAR) targeting the tumor-associated antigen (TAA) CD19 and containing, as of yet undisclosed co-stimulatory signaling domains, with potential immunostimulating and antineoplastic activities. Upon administration, anti-CD19 CAR T-cells XLCART001 targets and binds to CD19-expressing tumor cells, thereby inducing selective toxicity in CD19-expressing tumor cells. CD19 antigen is a B-cell specific cell surface antigen expressed in all B-cell lineage malignancies."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5173433", "l": "Monocytes | Cerebral spinal fluid | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:4033013", "l": "suprabasal keratinocyte", "d": ["A keratinocyte of the epidermis suprabasal layer. This cell may express the differentiation markers keratin 10 and keratin 1."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1267921", "l": "Lymphocyte positive for CD42A antigen", "d": []}, {"i": "SNOMEDCT:117589001", "d": []}]}
{"type": "biolink:Cell", "ic": "85.457082654197222", "identifiers": [{"i": "UMLS:C1519070", "l": "Physaliphorous Cell", "d": []}, {"i": "NCIT:C36739", "l": "Physaliphorous Cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157327", "l": "CD16+CD56+ cells | XXX | Cell markers", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2334089", "l": "Epithelial cell of thyroid gland", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5447406", "l": "Interferon Gamma-primed Human Bone Marrow-derived Mesenchymal Stromal Cells", "d": []}, {"i": "NCIT:C176740", "l": "Interferon Gamma-primed Human Bone Marrow-derived Mesenchymal Stromal Cells", "d": ["Human bone marrow-derived mesenchymal stromal cells (MSCs) primed with interferon gamma (IFN-g), with potential immunomodulatory activity. Upon priming with IFN-g and the administration of IFN-g-primed human bone marrow-derived MSCs, IFN-g activates the IFN-g-Janus kinase (JAK)-signal transducer and activator of transcription 1 (STAT1) signaling pathway and induces indoleamine 2,3-dioxygenase (IDO) expression in MSCs. This promotes IDO activity and enhances the inhibition of T-cell proliferation mediated by MSCs. This may enhance MSC-mediated immunosuppression and prevent graft-versus-host disease (GvHD)."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C4086004", "l": "Autologous Colorectal Tumor Antigen-pulsed Dendritic Cell Vaccine", "d": []}, {"i": "NCIT:C123918", "l": "Autologous Colorectal Tumor Antigen-pulsed Dendritic Cell Vaccine", "d": ["A dendritic cell (DC)-based cancer vaccine composed of autologous DCs pulsed with tumor cell lysates from a colorectal cancer patient containing tumor-associated antigens (TAAs), with potential immunostimulatory and antineoplastic activities. Upon administration, autologous colorectal tumor antigen-pulsed DC vaccine exposes the immune system to colorectal tumor cell antigens, which may result in cytotoxic T-lymphocyte (CTL)-mediated immune responses against the colorectal cancer cells. This leads to cancer cell lysis. The tumor cell lysate contains a range of antigens that are essential for the neoplastic growth and survival of the cancer cells."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0004232", "l": "starburst amacrine cell", "d": ["An amacrine cell with a flat dendritic arbor and a medium dendritic field. Starburst amacrine cells have post-synaptic terminals in S2. This cell type releases the neurotransmitters gamma-aminobutyric acid (GABA) and acetylcholine."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002162", "l": "internal epithelial cell of tympanic membrane", "d": ["An extremely flattened cell type found on the inner side of the tympanic membrane. The surface of this cell type carries sparse pleomorphic microvilli that are more common near the junctional zones."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5446933", "l": "Allogeneic NKG2D-OX40-CD3zeta-CAR-mbIL-15-expressing Natural Killer Cells NKX101", "d": []}, {"i": "NCIT:C176027", "l": "Allogeneic NKG2D-OX40-CD3zeta-CAR-mbIL-15-expressing Natural Killer Cells NKX101", "d": ["A preparation of off-the-shelf (OTS), allogeneic and ex vivo expanded natural killer cells (NKs) that are engineered to express membrane-bound IL-15 (mbIL15) and a chimeric antigen receptor (CAR) encoding for human natural-killer group 2, member D receptor protein (NKG2D; KLRK1; natural killer cell activating receptor group 2D) that is coupled to the co-stimulatory domain of OX40 (CD134), and to the zeta chain of the TCR/CD3 complex (CD3-zeta; CD3zeta), with potential immunomodulating and antineoplastic activities. Upon transfusion of the allogeneic NKG2D-OX40-CD3zeta-CAR-mbIL-15-expressing NKs NKX101, these cells specifically target and bind to tumor cells expressing NKG2D ligands (NKG2DL). This induces secretion of pro-inflammatory cytokines and results in the lysis of NKG2DL-expressing tumor cells. In addition, these cells target, bind to and kill NKG2DL-expressing tumor-associated endothelial cells in the neovasculature and immunosuppressive cells, such as regulatory T-cells (Tregs) and myeloid-derived suppressor cells (MDSCs) in the tumor microenvironment (TME) that express NKG2D ligands. IL-15 is a pro-survival cytokine that potentiates the immune response against tumor cells. NKG2D ligands are overexpressed in a variety of cancer cells."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1979649", "l": "Blasts.cytoplasmic CD2", "d": []}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "UMLS:C3896693", "l": "Bone Marrow-Derived Cell", "d": []}, {"i": "NCIT:C116388", "l": "Bone Marrow-Derived Cell", "d": ["A cell that is isolated from bone marrow."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0001081", "l": "group 2 innate lymphoid cell, human", "d": ["A group 2 innate lymphoid cell in the human with the phenotype CD25-positive, CD127-positive, CD161-positive, and GATA-3-positive."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5382749", "l": "CD107a+b expressing HLA-B7 Cytomegalovirus specific CD8 cells | Blood | Cell markers", "d": []}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "CL:0001011", "l": "immature interstitial dendritic cell", "d": ["Immature interstitial dendritic cell is a interstitial dendritic cell that is CD80-low, CD86-low, and MHCII-low."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1511062", "l": "Basaloid cell", "d": []}, {"i": "NCIT:C32190", "l": "Basaloid Cell", "d": ["A cell usually of the epidermis that resembles a basal cell."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4518158", "l": "Population of all motile spermatozoa in portion of fluid", "d": []}, {"i": "SNOMEDCT:726584006", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1511466", "l": "CY51", "d": []}, {"i": "NCIT:C20240", "l": "CY51", "d": ["Provider: CyThera, Inc., San Diego, CA. No information from provider. This cell line meets the criteria for the use of human embryonic stem cells by federally funded researchers."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002113", "l": "B220-low CD38-negative unswitched memory B cell", "d": ["A B220-low CD38-negative unswitched memory B cell is a CD38-negative unswitched memory B cell that has the phenotype B220-low, CD38-negative, IgD-positive, CD138-negative, and IgG-negative."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1955343", "l": "Other markers", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0001087", "l": "effector memory CD4-positive, alpha-beta T cell, terminally differentiated", "d": ["A CD4-positive, alpha beta memory T cell with the phenotype CD45RA-positive, CD45RO-negative, and CCR7-negative."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1516313", "l": "Castration Cell", "d": []}, {"i": "NCIT:C36752", "l": "Castration Cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4323049", "l": "Oocyte in dictyate arrest", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002629", "l": "mature microglial cell", "d": ["A mature microglial cell that has changed shape to an amoeboid morphology and is capable of cytokine production and antigen presentation."]}]}
{"type": "biolink:Cell", "ic": "86.236661114203869", "identifiers": [{"i": "CL:0001053", "l": "IgD-negative memory B cell", "d": ["A memory B cell that lacks expression of surface IgD."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5392346", "l": "KTE-X19", "d": []}]}
{"type": "biolink:Cell", "ic": "86.236661114203869", "identifiers": [{"i": "CL:0000632", "l": "hepatic stellate cell", "d": ["A cell that is found in the perisinusoidal space of the liver that is capable of multiple roles including storage of retinol, presentation of antigen to T cells (including CD1d-restricted NKT cells), and upon activation, production of extracellular matrix components that can contribute to liver fibrosis. This activated state has a myofibroblast-like phenotype, though it's not clear in the literature if this is terminally differentiated. This cell type comprises approximately 8-15% of total cells in the liver."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:2000061", "l": "placental amniotic mesenchymal stromal cell", "d": ["Any mesenchymal stem cell that is part of a placenta."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5690100", "l": "Cells.CD4+CD154+", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5420764", "l": "BCMA-CD19 Compound CAR T Cells", "d": []}, {"i": "NCIT:C174412", "l": "BCMA-CD19 Compound CAR T Cells", "d": ["A preparation of T-lymphocytes transduced with a lentiviral vector expressing a compound chimeric antigen receptor (cCAR) containing two distinct units of CARs, one specific for the tumor-associated antigen (TAA) B-cell maturation antigen (BCMA; tumor necrosis factor receptor superfamily member 17; TNFRSF17) and one specific for the TAA CD19, with potential immunomodulating and antineoplastic activities. Upon administration, the BCMA-CD19 cCAR T cells specifically and simultaneously target and bind to tumor cells expressing BCMA and/or CD19. This induces selective toxicity in tumor cells that express BCMA and/or CD19. BCMA, a tumor-specific antigen and a receptor for both a proliferation-inducing ligand (APRIL) and B-cell activating factor (BAFF), is a member of the tumor necrosis factor receptor superfamily (TNFRSF) and plays a key role in the survival of B-lymphocytes and plasma cells. BCMA is found on the surfaces of B-cells and is overexpressed on malignant plasma cells. CD19 is a B-cell-specific cell surface antigen overexpressed in B-cell lineage malignancies. Targeting two different antigens may improve coverage and protect against antigen escape and relapse as it is less likely for tumor cells to lose both antigens."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0946500", "l": "Cells.CD4+CD45+", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2333057", "l": "Myocyte of middle internodal tract", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5416853", "l": "Allogeneic Umbilical Cord Blood Derived Regulatory T-Cells", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002127", "l": "innate effector T cell", "d": ["A T cell with a receptor of limited diversity that is capable of immediate effector functions upon stimulation."]}]}
{"type": "biolink:Cell", "ic": "75.923665061460838", "identifiers": [{"i": "CL:0000359", "l": "vascular associated smooth muscle cell", "d": ["A smooth muscle cell associated with the vasculature."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:4023109", "l": "vasopressin-secreting magnocellular cell", "d": ["A magnocellular neurosecretory cell that is capable of producing and secreting vasopressin."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5238954", "l": "PBCAR20A", "d": []}, {"i": "NCIT:C168570", "l": "Allogeneic Anti-CD20-CAR T-cells PBCAR20A", "d": ["A preparation of allogeneic, off-the-shelf (OTS), T-lymphocytes, derived from healthy donors, that have been genetically modified using a proprietary synthetic endonuclease-based system to express a chimeric antigen receptor (CAR) targeting the tumor-associated antigen (TAA) CD20 (cluster of differentiation 20), with potential immunostimulating and antineoplastic activities. Upon administration, allogeneic anti-CD20-CAR T-cells PBCAR20A specifically recognize and kill CD20-expressing tumor cells. The CD20 antigen, a non-glycosylated cell surface phosphoprotein, is a B-cell specific cell surface antigen expressed in B-cell lineage malignancies."]}]}
{"type": "biolink:Cell", "ic": "38.935796485041756", "identifiers": [{"i": "CL:0002321", "l": "embryonic cell (metazoa)", "d": ["A cell of the embryo."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0011000", "l": "dorsal horn interneuron", "d": ["A CNS interneuron located in the dorsal horn of the spinal cord."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5177471", "l": "Plasma cells/100 leukocytes | Bronchial | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "UMLS:C1881552", "l": "Malignant Epithelial Small Oval Cell", "d": []}, {"i": "NCIT:C60999", "l": "Malignant Epithelial Small Oval Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0005013", "l": "single ciliated epithelial cell", "d": ["A ciliated epithelial cell with a single cilium."]}]}
{"type": "biolink:Cell", "ic": "89.347505587204751", "identifiers": [{"i": "UMLS:C1518170", "l": "Malignant Clear Squamous Cell", "d": []}, {"i": "NCIT:C36814", "l": "Malignant Clear Squamous Cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1267970", "l": "Lymphocyte positive for CD79A antigen", "d": []}, {"i": "SNOMEDCT:117410007", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2362006", "l": "Cells.CD3+CD4-CD8-CD45+", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2736930", "l": "Cells.CD19+CD34+", "d": []}]}
{"type": "biolink:Cell", "ic": "89.347505587204751", "identifiers": [{"i": "CL:0002261", "l": "endothelial cell of viscerocranial mucosa", "d": ["An endothelial cell found in the mucosa associated with the facial skeleton."]}]}
{"type": "biolink:Cell", "ic": "64.6720795298599", "identifiers": [{"i": "CL:0000021", "l": "female germ cell", "d": ["Female germ cell is a germ cell that supports female gamete production."]}]}
{"type": "biolink:Cell", "ic": "92.728541327098611", "identifiers": [{"i": "UMLS:C1881549", "l": "Malignant Epithelial Large Polygonal Cell", "d": []}, {"i": "NCIT:C61001", "l": "Malignant Epithelial Large Polygonal Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "57.861816010586786", "identifiers": [{"i": "CL:0002494", "l": "cardiocyte", "d": ["A cell located in the heart, including both muscle and non muscle cells."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5161802", "l": "Cytoplasmic CD3 blasts | Bone marrow | Cell markers", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4510923", "l": "Blast cell positive for CD2 antigen", "d": []}, {"i": "SNOMEDCT:725175007", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0000112", "l": "columnar neuron", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5667077", "l": "Anti-B7-H3 CAR T Cells TAA06", "d": []}, {"i": "NCIT:C186668", "l": "Anti-B7-H3 CAR T Cells TAA06", "d": ["A preparation of T-lymphocytes that have been genetically modified to express a chimeric antigen receptor (CAR) targeting the immunoregulatory protein B7-homologue 3 (B7-H3, CD276), with potential immunostimulating and antineoplastic activities. Upon administration, anti-B7-H3 CAR T-cells TAA06 target and bind to B7-H3-expressing tumor cells, thereby inducing selective toxicity in B7-H3-expressing tumor cells. B7-H3, a type I transmembrane protein and a member of the B7 co-stimulatory protein superfamily, is overexpressed on certain tumor cell types and on various immune cells. It is a negative regulator of T-cell activation and its overexpression plays a key role in tumor cell invasion and metastasis."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1565000", "l": "Retinal Horizontal Cells", "d": []}, {"i": "MESH:D051248", "l": "Retinal Horizontal Cells", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002147", "l": "clear chief cell of parathyroid gland", "d": ["A chief cell of parathyroid glands that does not stain with hematoxylin or eosin. This cell is larger, has a larger nucleus and fewer secretory granules than dark chief cells."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0000193", "l": "cardiac muscle cell (sensu Arthopoda)", "d": ["A striated muscle cell of an arthropod heart that participates in heart contraction."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0003011", "l": "G8 retinal ganglion cell", "d": ["A mono-stratified retinal ganglion cell that has a large dendritic field and a sparse dendritic arbor with post synaptic terminals in sublaminar layer S4."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0312867", "l": "Sensitized platelet", "d": []}, {"i": "SNOMEDCT:65533007", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1440307", "l": "Cells.CD41a", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2336440", "l": "Secondary motor neuron", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1522151", "l": "Leukocyte - Lymphocyte - Thymocyte (MMHCC)", "d": []}, {"i": "NCIT:C22583", "l": "Mouse Thymocyte", "d": []}]}
{"type": "biolink:Cell", "ic": "88.140761698499901", "identifiers": [{"i": "CL:2000060", "l": "placental villous trophoblast", "d": ["A trophoblast of placental villi.  These cells fuse to form synctial  trophoplast - the placental side of the interface between the placenta and maternal blood sinusoids in the decidua."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C3494180", "l": "Bone Marrow Stromal Cells, Multipotent", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1182609", "l": "Epithelial cell of choroid plexus", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5180575", "l": "Segmented neutrophils | Body fluid | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2327311", "l": "Stromal cell of ovarian cortex", "d": []}]}
{"type": "biolink:Cell", "ic": "51.884101144824598", "identifiers": [{"i": "CL:0000215", "l": "barrier cell", "d": ["A cell whose primary function is to prevent the transport of stuff across compartments."]}]}
{"type": "biolink:Cell", "ic": "89.347505587204751", "identifiers": [{"i": "CL:0002198", "l": "oncocyte", "d": ["A large epithelial cell with an extremely acidophilic and granular cytoplasm, containing vast numbers of mitochondria; such cells may undergo neoplastic transformation. From the Greek word onkos meaning swelling, this cell type is found in parathyroid, salivary and thyroid glands."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0333839", "l": "Lipid histiocyte", "d": []}, {"i": "SNOMEDCT:76237002", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5420429", "l": "Autologous Anti-GD2-CAR-BBz-iCasp9 Retroviral Vector-transduced T Lymphocytes", "d": []}, {"i": "NCIT:C173886", "l": "Autologous Anti-GD2-CAR-BBz-iCasp9 Retroviral Vector-transduced T Lymphocytes", "d": ["A preparation of genetically modified autologous T-lymphocytes transduced with a retroviral vector encoding a chimeric antigen receptor (CAR) consisting of a single chain variable fragment (scFv) derived from the monoclonal antibody 14g2a that is specific for the disialoganglioside GD2 and the co-stimulatory domain 4-1BB (CD137) coupled to the zeta chain of the TCR/CD3 complex (CD3-zeta), and fused with the suicide gene inducible caspase 9 (iCasp9), with potential immunomodulating and antineoplastic activities. Upon intravenous administration of the autologous anti-GD2-CAR-BBz-iCasp9 retroviral vector-transduced T lymphocytes, these cells target the GD2 antigen on tumor cells, thereby providing selective toxicity towards GD2-expressing tumor cells. The tumor-associated antigen (TAA) GD2 is overexpressed on the surface of neuroblastoma cells and by other neuroectoderm-derived neoplasms, while it is minimally expressed on normal cells. iCasp9 consists of a human FK506 drug-binding domain with an F36V mutation (FKBP12-F36V) linked to human caspase 9. If the administered T-cells lead to unacceptable side effects, the chemical homodimerizer AP1903 can be administered; this binds to the drug binding FKBP12-F36V domain and activates caspase 9, which results in the apoptosis of the administered T-cells and enhances safety of this agent."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002470", "l": "MHC-II-positive classical monocyte", "d": ["Gr1-high monocyte that has a MHC-II receptor complex."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1440292", "l": "Cells.CD3+TCR", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C4725081", "l": "Allogeneic interleukin-17-producing CD8-positive T-cells", "d": []}, {"i": "NCIT:C148499", "l": "Allogeneic interleukin-17-producing CD8-positive T-cells", "d": ["A preparation of allogeneic human cytotoxic T-lymphocytes that express the pro-inflammatory cytokine interleukin-17 (IL-17; IL17), with potential immunomodulating and anti-tumor activities. Upon ex vivo stimulation, the IL-17-producing CD8-positive T-cells (Tc17) convert to interferon-gamma (IFNg; IFN-g)-producing CD8-positive T-cells (Tc1). Tc1 cells exert enhanced anti-tumor cytotoxicity. Human Tc17 cells may contribute to a number of human inflammatory and malignant diseases."]}]}
{"type": "biolink:Cell", "ic": "78.435418415656045", "identifiers": [{"i": "CL:0000295", "l": "somatotropin secreting cell", "d": ["A peptide hormone secreting cell that produces growth hormone, somatotropin."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1517771", "l": "Lepra Cell", "d": []}, {"i": "NCIT:C36737", "l": "Lepra Cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5555864", "l": "Oncolytic Adenovirus ICOVIR5-infected Allogeneic Mesenchymal Stem Cells", "d": []}]}
{"type": "biolink:Cell", "ic": "88.140761698499901", "identifiers": [{"i": "CL:0009101", "l": "fibroblastic reticular cell", "d": ["A reticular cell involved in directing B cells and T cells to specific regions within a tissue."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:1000289", "l": "myocyte of atrial septal branch of anterior internodal tract", "d": ["A muscle cell that is part of the atrial septal branch of anterior internodal tract."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4322185", "l": "Epithelial cell of exocervix", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0682524", "l": "fibroblast cell line", "d": []}]}
{"type": "biolink:Cell", "ic": "72.072061987060081", "identifiers": [{"i": "UMLS:C1708862", "l": "Malignant Cell with Eosinophilic Cytoplasm", "d": []}, {"i": "NCIT:C53644", "l": "Malignant Cell with Eosinophilic Cytoplasm", "d": []}]}
{"type": "biolink:Cell", "ic": "76.10017597303252", "identifiers": [{"i": "UMLS:C1708873", "l": "Malignant Epithelial Large Cell with Vesicular Nucleus and Distinct Nucleolus", "d": []}, {"i": "NCIT:C54387", "l": "Malignant Epithelial Large Cell with Vesicular Nucleus and Distinct Nucleolus", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0545060", "l": "Peripheral blood (P.B.), abnormal cell", "d": []}]}
{"type": "biolink:Cell", "ic": "89.347505587204751", "identifiers": [{"i": "UMLS:C1514079", "l": "Neoplastic Round Neuroepithelial Cell", "d": []}, {"i": "NCIT:C42092", "l": "Neoplastic Round Neuroepithelial Cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2326742", "l": "Goblet cell of epithelium proper of small intestine", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0228129", "l": "Outer mesothelial cell", "d": []}, {"i": "SNOMEDCT:90459004", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5154475", "l": "Basophils | Blood cord | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5770493", "l": "MB-102 CD123 CAR", "d": []}]}
{"type": "biolink:Cell", "ic": "92.728541327098611", "identifiers": [{"i": "UMLS:C3273605", "l": "Disseminated Tumor Cell", "d": []}, {"i": "NCIT:C97750", "l": "Disseminated Tumor Cell", "d": ["Metastatic tumor cells found singly or in small clusters in the tissues."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002279", "l": "type L enteroendocrine cell", "d": ["A enteroendocrine cell type that is numerous in ileum, present in jejunum and large intestine, few in duodenum. This cell type produces glucagon-like immunoreactants (glicentin, glucagon-37, glucagon-29, GLP-1 and -2) and PYY."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C0162556", "l": "Suppressor inducer T lymphocyte", "d": []}, {"i": "NCIT:C12541", "l": "Suppressor-Inducer T-Lymphocyte", "d": ["A subtype of CD4+ T lymphocyte that triggers CD8+ T lymphocytes to inhibit the production of antibodies."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002366", "l": "myometrial cell", "d": ["A smooth muscle cell of the myometrium that enlarges and stretches during pregnancy, and contracts in response to oxytocin."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5163440", "l": "Eosinophils | Fetus | Pleural fluid | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C4726059", "l": "Autologous CD19-CD8-CD28-CD3zeta-CAR-mbIL15-HER1t T Cells", "d": []}, {"i": "NCIT:C150906", "l": "Autologous CD19-CD8-CD28-CD3zeta-CAR-mbIL15-HER1t T Cells", "d": ["A preparation of autologous, genetically modified T-lymphocytes, that have been electroporated ex vivo with sleeping beauty (SB)-derived DNA plasmids, expressing a second-generation chimeric antigen receptor (CAR) composed of a mouse single-chain variable fragment (scFv) specific for the tumor-associated antigen (TAA) cluster of differentiation 19 (CD19) that is linked to the co-stimulatory molecules T-cell surface glycoproteins CD8 and CD28 and the zeta chain of the T-cell receptor (TCR)/CD3 complex (CD3-zeta) and co-expressed with a chimeric membrane-bound fusion protein comprised of interleukin-15 (IL-15) fused to IL-15 receptor (mbIL15) and a safety/kill switch composed of a truncated form of the human epidermal growth factor receptor (ErbB1t; EGFR) (HER1t), with potential immunostimulating and antineoplastic activities. Upon reintroduction of the autologous CD19-CD8-CD28-CD3zeta-CAR-mbIL15-HER1t T cells into the patient, the T-cells target and bind to CD19-expressing tumor cells, thereby inducing selective toxicity in CD19-expressing tumor cells. CD19 is a B-cell specific cell surface antigen expressed in all B-cell lineage malignancies.  HER1t can promote selective elimination of the CAR-T cells through cetuximab-induced antibody-dependent cellular cytotoxicity (ADCC) and complement-dependent cytotoxicity (CDC). IL-15 is a pro-survival cytokine that is required for the maintenance of long-lived CD8+ memory T-cells and use of mbIL15 preserves T stem-cell memory (TSCM) through sustained IL-15 signaling, improves T-cell persistence and potentiates the immune response against tumor cells. The SB system permits electroporation of the CAR, the IL-15 fusion variant and safety switch transgenes into T-cells without the need for viral vectors and accelerates the manufacturing process."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5182775", "l": "TCR alpha beta cells | Blood | Cell markers", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0004216", "l": "type 5b cone bipolar cell", "d": ["A type 5 cone bipolar cell with diffuse axonal branches."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0314590", "l": "Colony-forming unit, granulocyte-monocyte", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0945925", "l": "Cells.CD3+CD25+", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:1000352", "l": "basal cell of epithelium of lobular bronchiole", "d": ["A basal cell that is part of the epithelium of bronchiole."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0004217", "l": "H1 horizontal cell", "d": ["A horizontal cell with a large cell body, thick dendrites, and a large dendritic arbor."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:4023122", "l": "oxytocin receptor sst GABAergic cortical interneuron", "d": ["An interneuron located in the cerebral cortex that expresses the oxytocin receptor. These interneurons also express somatostatin."]}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "CL:4006000", "l": "fibroblast of breast", "d": ["A fibroblast that is part of the breast."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C4684891", "l": "Anti-K-RAS G12V mTCR-transduced Autologous Peripheral Blood Lymphocytes", "d": []}, {"i": "NCIT:C142888", "l": "Anti-K-RAS G12V mTCR-transduced Autologous Peripheral Blood Lymphocytes", "d": ["Autologous peripheral blood lymphocytes (PBLs) transduced with an HLA class I histocompatibility antigen A*11:01 (HLA-A1101)-restricted murine T-cell receptor (mTCR) that recognizes the glycine to valine point mutation at position 12 (G12V) variant of K-RAS, with potential antineoplastic activity. HLA-A1101 positive PBLs are harvested from a K-RAS G12V-expressing cancer patient and transfected with a retroviral vector that encodes anti-K-RAS G12V mTCR. The transduced PBLs are then expanded in culture. When reintroduced to the patient, these anti-K-RAS G12V mTCR-expressing PBLs target and bind to K-RAS G12V-overexpressing tumor cells, which results in both cytokine secretion and tumor cell lysis. K-RAS, a member of the RAS family of oncogenes, serves an important role in cell signaling, division and differentiation. Mutation of K-RAS may induce constitutive signal transduction leading to tumor cell growth, proliferation, invasion, and metastasis."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C3849991", "l": "Glandular Epithelial Cells", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0598089", "l": "established cell line", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0333840", "l": "Non-lipid histiocyte", "d": []}, {"i": "SNOMEDCT:42766006", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:1000378", "l": "type 1 vestibular sensory cell of stato-acoustic epithelium", "d": ["A type I vestibular sensory cell that is part of the stato-acoustic epithelium."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1513923", "l": "Neoplastic Acidophilic Stem Cell", "d": []}, {"i": "NCIT:C36924", "l": "Neoplastic Acidophilic Stem Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C4764048", "l": "Anti-FL(FITC-E2) CAR T Cells", "d": []}, {"i": "NCIT:C158099", "l": "Anti-FL(FITC-E2) CAR T Cells", "d": ["A preparation of genetically modified T-cells transduced with a replication incompetent, self-inactivating (SIN) lentiviral vector expressing a second generation chimeric antigen receptor (CAR) consisting of an anti-fluorescein (anti-FL) fluorescein isothiocyanate (FITC)-E2 single chain variable fragment (scFv), that is coupled, via an immunoglobulin G4 (IgG4) hinge-CH2(L295D)-CH3 spacer, to the costimulatory signaling molecules CD28, CD137 (4-1BB), and CD3 zeta, and linked to a truncated form of the human epidermal growth factor receptor (EGFRt), with potential immunostimulating and antineoplastic activities. Prior to the administration of anti-FL(FITC-E2) CAR T-cells, the CAR-T adaptor molecule (CAM) EC17 is administered. EC17 is a bispecific molecule that is composed of folic acid conjugated to FITC (folate-FITC). EC17 targets and binds with its folate moiety with high affinity to folate receptor (FR)-expressing tumor cells. Upon administration of the anti-FL(FITC-E2) CAR T-cells, these cells are attracted by and bind to the FITC antigen moiety of EC17. Upon binding to EC17, the T-cells induce specific tumor cell lysis, cytokine secretion, and proliferation, and activate a robust immune response against the EC17-bound, FR-expressing tumor cells. FR is overexpressed in various tumor cell types and is associated with increased leukemic cell proliferation and aggressiveness. The co-stimulatory molecules are required for full T-cell activation and enhance both proliferation of T-cells and antitumor activity. EGFRt both facilitates detection of the administered T-cells in vivo and can promote elimination of those cells following a cetuximab-induced antibody-dependent cellular cytotoxicity (ADCC) response. The reactivity of the anti-FL(FITC-E2) CAR T-cells is dependent on dosing of EC17, and therefore allows CAR T-cell activity to be controlled by dosing of EC17."]}]}
{"type": "biolink:Cell", "ic": "85.457082654197222", "identifiers": [{"i": "CL:0000820", "l": "B-1a B cell", "d": ["A B-1 B cell that has the phenotype CD5-positive."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C0007635", "l": "Cultured Cells", "d": []}, {"i": "NCIT:C45382", "l": "Cell Strain", "d": ["Cells adapted to culture, but with finite division potential."]}, {"i": "MESH:D002478", "l": "Cells, Cultured", "d": []}, {"i": "SNOMEDCT:702451000", "d": []}]}
{"type": "biolink:Cell", "ic": "92.728541327098611", "identifiers": [{"i": "CL:4030040", "l": "endometrial ciliated epithelial cell", "d": ["A ciliated cell of the endometrial epithelium. The cilia of this cell type help move mucus from glandular tissue of the endometrium."]}]}
{"type": "biolink:Cell", "ic": "88.140761698499901", "identifiers": [{"i": "CL:1000480", "l": "transitional myocyte of internodal tract", "d": ["A transitional myocyte that is part of the internodal tract."]}]}
{"type": "biolink:Cell", "ic": "92.728541327098611", "identifiers": [{"i": "UMLS:C0242632", "l": "T-helper cell type 1", "d": []}, {"i": "NCIT:C12539", "l": "Type 1 Helper Cell", "d": ["Type 1 Helper Cells are a subset of helper-inducer T-lymphocytes which synthesize and secrete interleukin-2, gamma-interferon, and interleukin-12. Due to their ability to kill antigen-presenting cells and their lymphokine-mediated effector activity, these cells are associated with delayed-type hypersensitivity reactions."]}, {"i": "MESH:D018417", "l": "Th1 Cells", "d": []}, {"i": "SNOMEDCT:418698006", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2338967", "l": "Interleukin 12-activated natural killer cell", "d": []}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "UMLS:C1518185", "l": "Malignant Langerhans Cell", "d": []}, {"i": "NCIT:C36890", "l": "Malignant Langerhans Cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "MESH:D013172", "l": "Spores, Fungal", "d": []}]}
{"type": "biolink:Cell", "ic": "75.923665061460838", "identifiers": [{"i": "UMLS:C0031760", "l": "Photoreceptors", "d": []}, {"i": "NCIT:C12634", "l": "Photoreceptor Cell", "d": ["A sensory neuron, located in the retina of the eye, that converts light signals into nerve impulses."]}, {"i": "MESH:D010786", "l": "Photoreceptor Cells", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C3899033", "l": "Genetically Engineered Hematopoietic Stem Progenitor Cells", "d": []}, {"i": "NCIT:C119988", "l": "Genetically Engineered Hematopoietic Stem Progenitor Cells", "d": ["Gene modified hematopoietic stem progenitor cells (HSPCs)."]}]}
{"type": "biolink:Cell", "ic": "87.120474278337809", "identifiers": [{"i": "UMLS:C1514004", "l": "Neoplastic T-Cell Large Granular Lymphocyte", "d": []}, {"i": "NCIT:C37019", "l": "Neoplastic T-Cell Large Granular Lymphocyte", "d": []}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "CL:4030036", "l": "early spermatid", "d": ["A spermatid in an early stage of maturation that has a round morphology and is transcriptionally active."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5216313", "l": "Polymorphonuclear cells|NCnc|Pt|Synv fld", "d": []}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "UMLS:C0879357", "l": "Vaccine-Sensitized Draining Lymph Node Cells", "d": []}, {"i": "NCIT:C2542", "l": "Vaccine-Sensitized Draining Lymph Node Cells", "d": ["Cells isolated from lymph nodes from patients, and activated in vitro to generate tumor-specific effector T cells.  Lymph nodes in the lymphatics draining tumors often contain T cells that are immunologically sensitized but functionally deficient. Vaccine-sensitized draining lymph node cells are prepared by isolating these lymphocytes in vitro and stimulating them with cytokines to differentiate into mature effector cells.  Vaccine-draining lymph node cells may also be produced by pharmacological activation of lymph node-derived lymphocytes with drugs such as ionomycin or with bacterial toxin; these activated lymphocytes may be expanded in culture with cytokines such as interleukin-2 prior to infusion into the patient. (NCI04)"]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1183324", "l": "Endothelial cell of venous sinusoid of spleen", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:2000091", "l": "endometrial microvascular endothelial cell", "d": ["Any microvascular endothelial cell that is part of a endometrial blood vessel."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5161799", "l": "Cytoplasmic CD22 blasts | Bone marrow | Cell markers", "d": []}]}
{"type": "biolink:Cell", "ic": "73.721563224321088", "identifiers": [{"i": "CL:0000815", "l": "regulatory T cell", "d": ["A T cell which regulates overall immune responses as well as the responses of other T cell subsets through direct cell-cell contact and cytokine release."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157628", "l": "CD59 RBC | Blood | Cell markers", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2951309", "l": "Endothelial cell of endocardium for left atrium", "d": []}]}
{"type": "biolink:Cell", "ic": "90.82444074280258", "identifiers": [{"i": "CL:0008035", "l": "microcirculation associated smooth muscle cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4511892", "l": "Population of all schistocytes in portion of fluid", "d": []}, {"i": "SNOMEDCT:726510009", "d": []}]}
{"type": "biolink:Cell", "ic": "92.728541327098611", "identifiers": [{"i": "UMLS:C0024156", "l": "Luteal Cells", "d": []}, {"i": "NCIT:C12610", "l": "Lutein Cell", "d": ["A cell located in the corpus luteum of the ovary that is derived from theca or granulosa cells and secretes progesterone and estrogen or androgens."]}, {"i": "MESH:D008184", "l": "Luteal Cells", "d": []}]}
{"type": "biolink:Cell", "ic": "88.140761698499901", "identifiers": [{"i": "UMLS:C1881595", "l": "Malignant Small Round Cell with Scant Amount of Dark Granular Cytoplasm", "d": []}, {"i": "NCIT:C60805", "l": "Malignant Small Round Cell with Scant Amount of Dark Granular Cytoplasm", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2336699", "l": "Fibroblast of areolar connective tissue", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:4023124", "l": "dentate gyrus kisspeptin neuron", "d": ["A kisspeptin neuron that is located in the dentate gyrus of the hippocampus."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C4763523", "l": "Autologous CLL1-CD33 Compound CAR T Cells", "d": []}, {"i": "NCIT:C157281", "l": "Autologous CLL1-CD33 Compound CAR T Cells", "d": ["Autologous T-lymphocytes transduced with a lentiviral vector expressing a compound chimeric antigen receptor (cCAR) containing two CARs, one specific for the CD33 antigen and one specific for the C-type-lectin-like molecule-1 (CLL1; C-type lectin domain family 12 member A; CLEC12A), with potential immunomodulating and antineoplastic activities. Upon administration, the CD33/CLL1-specific CARs lentiviral vector-transduced autologous T-lymphocytes, expressing both the anti-CD33 CAR and the anti-CLL1 CAR on their surfaces, specifically and simultaneously target and bind to CD33- and CLL1-expressing tumor cells, with their anti-CD33 CAR and their anti-CLL1 CAR, respectively. This induces selective toxicity in tumor cells that express the CD33 antigen and the CLL1 antigen. CD33 is expressed on normal non-pluripotent hematopoietic stem cells and is overexpressed on myeloid leukemia cells. CLL1, a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily, is overexpressed in leukemic stem cells (LSCs) and plays an important role in disease progression and relapse for myeloid malignancies."]}]}
{"type": "biolink:Cell", "ic": "90.82444074280258", "identifiers": [{"i": "CL:0002666", "l": "type 2 otic fibrocyte", "d": ["An otic fibrocyte that underlies the spiral prominence and is part of a mesenchymal gap junction network that regulates ionic homeostasis of the endolymph."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1979668", "l": "CD19+IgD+ cell", "d": []}, {"i": "SNOMEDCT:732276002", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1267977", "l": "Lymphocyte positive for CD87 antigen", "d": []}, {"i": "SNOMEDCT:117417005", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1563926", "l": "Th3 Cells", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002123", "l": "B220-low CD38-positive IgG-negative class switched memory B cell", "d": ["A B220-low CD38-positive IgG-negative memory B cell is a CD38-positive IgG-negative class switched memory B cell that lacks IgG on the cell surface with the phenotype B220-low, CD38-positive, and IgG-positive."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1184107", "l": "Myoepithelial cell of acinus of lactiferous gland", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0314588", "l": "Colony-Forming Units, Granulocyte-Erythroid-Macrophage-Megakaryocyte", "d": []}, {"i": "SNOMEDCT:444993001", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1181723", "l": "Cortical cell of adrenal gland", "d": []}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "CL:1000312", "l": "bronchial goblet cell", "d": ["A goblet cell that is part of the epithelium of bronchus."]}]}
{"type": "biolink:Cell", "ic": "57.140620149305498", "identifiers": [{"i": "CL:0000051", "l": "common lymphoid progenitor", "d": ["A oligopotent progenitor cell committed to the lymphoid lineage."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C4763664", "l": "CD56-enriched CD3-positive Donor Lymphocytes", "d": []}, {"i": "NCIT:C157500", "l": "CD56-enriched CD3-positive Donor Lymphocytes", "d": ["A population of CD3-positive lymphocytes expressing the CD56 surface antigen, with potential immunomodulating activity. Upon infusion of the CD56-enriched CD3-positive donor lymphocytes, these cells may facilitate the reconstitution of CD4-positive T-cells, regulatory T-cells (Tregs) and natural killer (NK) cells, which may reduce the incidence of post-transplant graft-versus-host disease (GvHD) following haploidentical stem cell transplant (SCT). CD56 is a transmembrane glycoprotein also known as neural cell adhesion molecule 1 (NCAM-1)."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4696006", "l": "Cells.CD3+CD4+CD27+CD62L+", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5761773", "l": "PBCAR269A", "d": []}]}
{"type": "biolink:Cell", "ic": "92.728541327098611", "identifiers": [{"i": "UMLS:C0206427", "l": "Rod Photoreceptors", "d": []}, {"i": "NCIT:C12638", "l": "Retinal Rod", "d": ["A photoreceptor cell located in the retina of the eye that allows low light vision."]}, {"i": "MESH:D017948", "l": "Retinal Rod Photoreceptor Cells", "d": []}, {"i": "SNOMEDCT:17139002", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4304489", "l": "Population of all macrophages in portion of fluid", "d": []}, {"i": "SNOMEDCT:719699000", "d": []}]}
{"type": "biolink:Cell", "ic": "89.347505587204751", "identifiers": [{"i": "UMLS:C0682638", "l": "Memory B Cells", "d": []}, {"i": "NCIT:C13123", "l": "Memory B-Lymphocyte", "d": ["A subset of mature B-lymphocytes that are formed during primary antigen exposure, survive for many years after the infection has resolved and maintain specificity toward the primary antigen. These cells can quickly produce a large amount of antigen-specific antibodies in response to a subsequent exposure."]}, {"i": "MESH:D000091245", "l": "Memory B Cells", "d": []}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "UMLS:C1512640", "l": "Immature Spindle Cell", "d": []}, {"i": "NCIT:C36958", "l": "Immature Spindle Cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1955257", "l": "Erythrocytes.fresh", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C4055475", "l": "Alzheimer Type II Astrocyte", "d": []}, {"i": "NCIT:C120911", "l": "Alzheimer Type II Astrocyte", "d": ["An abnormal and pathological astrocyte which appears enlarged and metabolically hyperactive. It is characterized by the presence of vesicular and basophilic nuclei. This cell type is not associated with Alzheimer's Disease."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5175157", "l": "Nucleated erythrocytes | Blood | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1267938", "l": "Lymphocyte positive for CD49C antigen", "d": []}, {"i": "SNOMEDCT:117381002", "d": []}]}
{"type": "biolink:Cell", "ic": "89.347505587204751", "identifiers": [{"i": "UMLS:C1710537", "l": "Undifferentiated Neoplastic Blast", "d": []}, {"i": "NCIT:C42873", "l": "Undifferentiated Neoplastic Blast", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1657751", "l": "Cells.CD4+CD7+", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1267900", "l": "Lymphocyte positive for CD27 antigen", "d": []}, {"i": "SNOMEDCT:117571002", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C3496269", "l": "B6 serotonin cells", "d": []}]}
{"type": "biolink:Cell", "ic": "81.648881485605159", "identifiers": [{"i": "CL:0002260", "l": "epithelial cell of parathyroid gland", "d": ["An epithelial cell of the parathyroid gland."]}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "UMLS:C1513410", "l": "Monkey Cell Line", "d": []}, {"i": "NCIT:C20219", "l": "Monkey Cell Line", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0427533", "l": "Hypogranular white blood cell", "d": []}, {"i": "SNOMEDCT:250292003", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0314586", "l": "Colony-forming unit of eosinophilic lineage", "d": []}, {"i": "SNOMEDCT:445115004", "d": []}]}
{"type": "biolink:Cell", "ic": "74.240948556675605", "identifiers": [{"i": "CL:0000157", "l": "surfactant secreting cell", "d": ["A cell that specializes in secretion of surfactant in the alveoli of the lung."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0000389", "l": "socket cell (sensu Nematoda)", "d": []}]}
{"type": "biolink:Cell", "ic": "77.488267285704651", "identifiers": [{"i": "UMLS:C1514012", "l": "Neoplastic Mast Cell", "d": []}, {"i": "NCIT:C37062", "l": "Neoplastic Mast Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5555502", "l": "Human Embryonic Stem Cell-derived Midbrain Dopamine Neuron Cells MSK-DA01", "d": []}, {"i": "NCIT:C179167", "l": "Human Embryonic Stem Cell-derived Midbrain Dopamine Neuron Cells MSK-DA01", "d": ["A preparation of midbrain dopamine neurons derived from human embryonic stem cells that could potentially be used for the treatment of Parkinson's disease (PD). Upon administration and transplantation of the human embryonic stem cell-derived midbrain dopamine neuron cells MSK-DA01 into the putamen, these nerve cells may replenish the dopaminergic cells that are lost in PD patients and produce dopamine, thereby alleviating PD symptoms."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C3178741", "l": "Be2 Cells", "d": []}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "UMLS:C1882048", "l": "Neoplastic Epithelial Cell with Granular Cytoplasm", "d": []}, {"i": "NCIT:C62102", "l": "Neoplastic Epithelial Cell with Granular Cytoplasm", "d": []}]}
{"type": "biolink:Cell", "ic": "81.247621244257502", "identifiers": [{"i": "CL:0002132", "l": "stromal cell of ovary", "d": ["A stomal cell of the ovary"]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1515127", "l": "T-Cell Large Granular Lymphocyte", "d": []}, {"i": "NCIT:C38673", "l": "T-Cell Large Granular Lymphocyte", "d": ["A thymus-dependent white blood cell that has been activated by contact with antigen and has enlarged by macromolecular synthesis with presence of large granules visible by light microscopy."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C4086900", "l": "Therapeutic Dendritic Cells/Cytokine-induced Killer Cells", "d": []}, {"i": "NCIT:C123819", "l": "Therapeutic Dendritic Cells/Cytokine-induced Killer Cells", "d": ["A preparation of autologous dendritic cells (DC) mixed with cytokine-induced killer (CIK) cells (DC-CIK), with potential immunopotentiating and antineoplastic activities. DCs were obtained ex vivo by incubation of peripheral blood lymphocytes (PBLs) with granulocyte-macrophage colony-stimulating factor stimulating factor (GM-CSF or CSF2), tumor necrosis factor (TNF), and interleukin (IL)-24 and were sensitized with tumor-associated antigens (TAAs). Cytokine-induced killer (CIK) cells are immune effector cells with both T-cell and natural killer (NK) cell like phenotype. CIKs are non-major histocompatibility complex (MHC)-restricted, NK-like T-lymphocytes, which express both CD3, a T-cell surface marker, and CD56, a natural killer cell surface marker, and have been generated ex vivo by incubation of peripheral blood lymphocytes (PBLs) with anti-CD3 monoclonal antibody, IL-2, IL-1 alpha, and interferon gamma (IFN-gamma) and then expanded. Upon co-culture of DCs and CIKs, and administration of DC-CIK cells into the patient, the DCs are able to stimulate the immune response to exert a specific anti-tumor immune response, while the CIK cells exert direct oncolytic activity."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0229651", "l": "Promegakaryocytes", "d": []}, {"i": "SNOMEDCT:50284009", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1267930", "l": "Lymphocyte positive for CD45RA antigen", "d": []}, {"i": "SNOMEDCT:117373003", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1517817", "l": "Leukocyte - Lymphocyte - Immature T-Lymphocyte (MMHCC)", "d": []}, {"i": "NCIT:C22579", "l": "Mouse Immature T-Lymphocyte", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:1001223", "l": "interlobulary vein endothelial cell", "d": []}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "CL:0005003", "l": "leucoblast", "d": ["A non-terminally differentiated cell that originates from the neural crest and differentiates into a leucophore."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1268010", "l": "Megakaryocytic cell", "d": []}, {"i": "SNOMEDCT:127918005", "d": []}]}
{"type": "biolink:Cell", "ic": "72.370703631459492", "identifiers": [{"i": "CL:1000504", "l": "kidney medulla cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5216288", "l": "Neutrophils.segmented|NCnc|Pt|Bld", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5425000", "l": "Cells.CD3+CD8+CD27+CD45RO+CD62L+", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C4733644", "l": "Autologous Anti-CD19 CAR T-cells IM19", "d": []}, {"i": "NCIT:C155888", "l": "Autologous Anti-CD19 CAR T-cells IM19", "d": ["A preparation of autologous T-lymphocytes that have been genetically modified and transduced with a lentiviral vector expressing a chimeric antigen receptor (CAR) targeting the tumor-associated antigen (TAA) CD19 and containing, as of yet undisclosed co-stimulatory signaling domains, with potential immunostimulating and antineoplastic activities. Upon administration, autologous anti-CD19 CAR T-cells IM19 target and bind to CD19-expressing tumor cells, thereby inducing selective toxicity in CD19-expressing tumor cells. CD19 antigen is a B-cell specific cell surface antigen expressed in all B-cell lineage malignancies."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157369", "l": "CD2 cells | Body fluid | Cell markers", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5700414", "l": "Allogeneic Anti-CD19-CAR T-cells PBCAR0191", "d": []}, {"i": "NCIT:C158558", "l": "Azercabtagene Zapreleucel", "d": ["A preparation of allogeneic, off-the-shelf, T-lymphocytes that have been genetically modified using a proprietary synthetic nuclease-based system to express a chimeric antigen receptor (CAR) targeting the tumor-associated antigen (TAA) CD19 (cluster of differentiation 19) with potential immunostimulating and antineoplastic activities. Upon administration, azercabtagene zapreleucel specifically recognize and kill CD19-expressing tumor cells. CD19 antigen is a B-cell specific cell surface antigen, which is expressed in all B-cell lineage malignancies and normal B-cells."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1183360", "l": "Type-4 epithelial cell of thymus", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0004226", "l": "monostratified amacrine cell", "d": ["An amacrine cell with a small dendritic field with post-synaptic terminals in S3 and S4."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157494", "l": "CD34 cells | Blood product unit | Blood | Cell markers", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2335952", "l": "Type 2 vestibular sensory cell of epithelium of crista of ampulla of semicircular duct of membranous labyrinth", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2334370", "l": "Stellate cell of cerebral cortex", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002302", "l": "type A synovial cell", "d": ["A synovial cell that is macrophage-like, characterized by surface ruffles or lamellipodia, plasma membrane invaginations and associated micropinocytotic vesicles, Golgi apparatus and little granular endoplasmic reticulum."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5666877", "l": "Allogeneic Anti-CD7 CAR-T Cells WU-CART-007", "d": []}, {"i": "NCIT:C182072", "l": "Allogeneic Anti-CD7 CAR-T Cells WU-CART-007", "d": ["A preparation of off-the-shelf (OTS) donor-derived T-lymphocytes that have been genetically engineered to express a chimeric antigen receptor (CAR) directed against the tumor-associated antigen (TAA) CD7, with potential immunostimulating and antineoplastic activities. Upon intravenous administration, the allogeneic anti-CD7 CAR-T cells WU-CART-007 specifically recognize and bind to CD7-expressing tumor cells, resulting in specific T-cell-mediated tumor cell lysis. CD7 is a transmembrane glycoprotein expressed by T-cells and natural killer (NK) cells and their precursors. It is expressed in the majority of lymphoblastic T-cell leukemias and lymphomas and in a subset of peripheral T-cell lymphomas."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002652", "l": "endothelial cell of high endothelial venule", "d": ["A venule endothelial cell that is cubodial, expresses leukocyte-specific receptors, and allows for passage of lymphocytes into bloodstream."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1514591", "l": "Pseudoxanthoma Cell", "d": []}, {"i": "NCIT:C36740", "l": "Pseudoxanthoma Cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1440145", "l": "Blasts.CD20", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1180238", "l": "Capillary Endothelial Cells", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5446460", "l": "Donor-Derived Multi-Tumor-Associated Antigen-specific T Cells", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1135969", "l": "Large Luteal Cells", "d": []}, {"i": "NCIT:C32693", "l": "Granulosa Lutein Cell", "d": ["A cell of the corpus luteum of the ovary that is derived from the granulosa cells of the preovulatory follicle; it secretes progesterone and estrogen."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2334115", "l": "Set of Ch2 cholinergic cells", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C4287655", "l": "Autologous MAGE-A10-specific HLA-A2-restricted TCR c796 Gene-engineered Lymphocytes", "d": []}, {"i": "NCIT:C126686", "l": "Autologous MAGE-A10-specific HLA-A2-restricted TCR c796 Gene-engineered Lymphocytes", "d": ["Human autologous T-lymphocytes transduced with a retroviral vector encoding a high-affinity T-cell receptor (TCR) specific for human leukocyte antigen (HLA)-A2-restricted, human melanoma-associated antigen A10 (MAGE-A10), clone 796 (c796), with potential antineoplastic activity. Peripheral blood mononuclear cells (PBMCs) are isolated from a patient, transduced with an anti-MAGE-A10(c796)-HLA-A2 restricted TCR, expanded ex vivo, and reintroduced into the HLA-A2-positive patient. Upon reintroduction, the autologous MAGE-A10-specific, HLA-A2-restricted TCR c796 gene-engineered lymphocytes bind to tumor cells expressing the MAGE-A10 antigen, which may induce cell death in and halt the growth of MAGE-A10-expressing cancer cells. The tumor-associated antigen MAGE-A10, a member of the MAGE-A family of cancer/testis tumor-associated antigens (CT-TAAs), is overexpressed by a variety of cancer cell types."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1955381", "l": "Spermatozoa.angled midpiece", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002216", "l": "intermediate muscle cell", "d": ["An intermediate muscle cell that has characteristics of both fast and slow muscle cells."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157473", "l": "CD3+TCR gamma delta+ cells | Blood | Cell markers", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5666980", "l": "Anti-HPV16 TCR-engineered T-cells CRTE7A2-01", "d": []}, {"i": "NCIT:C185397", "l": "Anti-HPV16 TCR-engineered T-cells CRTE7A2-01", "d": ["A preparation of T-lymphocytes that has been genetically modified to express a T-cell receptor (TCR) specific for an as of yet not identified viral oncoprotein(s) of human papillomavirus type 16 (HPV16), with potential antineoplastic activity. Upon intravenous administration, the anti-HPV16 TCR-engineered T-cells CRTE7A2-01 specifically recognize and bind to the HPV16 oncoprotein(s) expressed on tumor cells. This may lead to cytotoxic T-lymphocyte (CTL)-mediated elimination of tumor cells expressing the HPV16 oncoprotein(s)."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1440310", "l": "Cells.CD42c", "d": []}]}
{"type": "biolink:Cell", "ic": "63.836170798622533", "identifiers": [{"i": "CL:0007004", "l": "premigratory neural crest cell", "d": ["Cell that is part of the neural crest region of the neuroepithelium, prior to migration. Note that not all premigratory neural crest cells may become migratory neural crest cells."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C4725101", "l": "Autologous CD20-4SCAR-expressing T-cells 4SCAR20", "d": []}, {"i": "NCIT:C148525", "l": "Autologous CD20-4SCAR-expressing T-cells 4SCAR20", "d": ["A preparation of genetically modified autologous T-cells transduced with a replication incompetent, self-inactivating lentiviral vector expressing a  fourth generation chimeric antigen receptor (4SCAR) consisting of an anti-CD20 single chain variable fragment (scFv) that is coupled to the costimulatory signaling domains CD28, CD137, CD27 and the zeta chain of the T-cell receptor (TCR), and is fused with the suicide gene inducible caspase 9 (iCasp9), with potential immunostimulating and antineoplastic activities. Upon intravenous administration, autologous CD20-4SCAR-expressing T-cells 4SCAR20 are directed to and induce selective toxicity in CD20-expressing tumor cells. iCasp9 consists of a human FK506 drug-binding domain with an F36V mutation (FKBP12-F36V) linked to human caspase 9. If the administered T-cells lead to unacceptable side effects, the chemical homodimerizer AP1903 can be administered. AP1903 binds to the drug binding FKBP12-F36V domain and induces activation of caspase 9, which results in the apoptosis of the administered T-cells and enhances safety of this agent. CD20 is a non-glycosylated cell surface phosphoprotein that is exclusively expressed on B-cells during most stages of B-cell development and is often overexpressed in B-cell malignancies. CD28, CD137 and CD27, T-cell surface-associated co-stimulatory molecules, are required for full T-cell activation and enhance both proliferation of T-cells and antitumor activity."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2323609", "l": "Type 1 vestibular sensory cell of epithelium of macula of saccule of membranous labyrinth", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0000256", "l": "uric acid accumulating cell", "d": []}]}
{"type": "biolink:Cell", "ic": "44.724197364059002", "identifiers": [{"i": "CL:0000219", "l": "motile cell", "d": ["A cell that moves by its own activities."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5420412", "l": "Allogeneic SARS-CoV-2 Specific T Cells", "d": []}, {"i": "NCIT:C173856", "l": "Allogeneic SARS-CoV-2 Specific T Cells", "d": ["A preparation of allogeneic T-lymphocytes specific for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), obtained from convalescent donors who have recovered from Coronavirus disease 2019 (COVID-19), with immunomodulating activity against COVID-19. Upon administration of the SARS-CoV-2 specific T cells, these cells may recognize and kill SARS-CoV-2-infected cells."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5380992", "l": "Cells.CD8.CMV specific.CMV antigen stimulated gamma interferon producing", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1718726", "l": "Cells.ZAP70", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4322829", "l": "Primitive neuroblast", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5418990", "l": "Allogeneic Anti-BCMA-CAR T-cells PBCAR269A", "d": []}, {"i": "NCIT:C171066", "l": "Allogeneic Anti-BCMA-CAR T-cells PBCAR269A", "d": ["A preparation of allogeneic, off-the-shelf, T-lymphocytes that have been genetically modified using a proprietary synthetic nuclease-based system to express a chimeric antigen receptor (CAR) targeting the tumor-associated antigen (TAA) B-cell maturation antigen (BCMA; tumor necrosis factor receptor superfamily member 17; TNFRSF17), with potential immunostimulating and antineoplastic activities. Upon administration, allogeneic anti-BCMA-CAR T-cells PBCAR269A specifically recognize and kill BCMA-expressing tumor cells. BCMA, a receptor for both a proliferation-inducing ligand (APRIL) and B-cell activating factor (BAFF), is a member of the tumor necrosis factor receptor superfamily (TNFRSF). BCMA is found on the surfaces of plasma cells, is overexpressed on malignant plasma cells and plays a key role in plasma cell proliferation and survival."]}]}
{"type": "biolink:Cell", "ic": "92.728541327098611", "identifiers": [{"i": "CL:1000360", "l": "microfold cell of epithelium proper of large intestine", "d": ["A M cell that is part of the epithelium proper of large intestine."]}]}
{"type": "biolink:Cell", "ic": "76.46797986554256", "identifiers": [{"i": "UMLS:C0879593", "l": "therapeutic autologous dendritic cells", "d": []}, {"i": "NCIT:C2594", "l": "Therapeutic Autologous Dendritic Cells", "d": ["A population of a type of antigen-presenting cell (APC), the dendritic cell (DC), harvested from a patient and grown in vitro in the presence of tumor-associated antigens (TAAs) derived from the patient's tumor (a technique known as 'pulsing') and then injected back into the patient; autologous DCs so manipulated may stimulate a specific cell-mediated antitumoral cytotoxicity. DCs derived from a patient may also be fused with the patient's tumor cells in vitro to combine sustained tumor antigen expression with the antigen-presenting and immunostimulatory capacities of DCs; when injected back into the patient, these autologous DC-tumor cell hybrids (fusion cells) may stimulate an active antitumoral immune response."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4287818", "l": "NiCord", "d": []}]}
{"type": "biolink:Cell", "ic": "72.072061987060081", "identifiers": [{"i": "UMLS:C1514080", "l": "Neoplastic Schwann Cell", "d": []}, {"i": "NCIT:C37151", "l": "Neoplastic Schwann Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "CL:0002601", "l": "uterine smooth muscle cell", "d": ["A smooth muscle cell of the uterus."]}]}
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{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5571777", "l": "Cells.CD19+CD79b+", "d": []}]}
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{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:2000068", "l": "pericardium fibroblast", "d": ["Any fibroblast that is part of a pericardium."]}]}
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{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1955255", "l": "Erythrocyte clumps", "d": []}]}
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{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0000874", "l": "splenic red pulp macrophage", "d": ["A splenic macrophage found in the red-pulp of the spleen, and involved in immune responses to blood-borne pathogens and in the clearance of senescent erythrocytes. Markers include F4/80-positive, CD68-positive, MR-positive, Dectin2-positive, macrosialin-positive, and sialoadhesin-low."]}]}
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{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5417765", "l": "Q-Cells", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C3828741", "l": "NY-ESO-1(157-165) Peptide-pulsed Autologous Dendritic Cell Vaccine", "d": []}, {"i": "NCIT:C114380", "l": "NY-ESO-1(157-165) Peptide-pulsed Autologous Dendritic Cell Vaccine", "d": ["A cell-based cancer vaccine composed of autologous dendritic cells (DCs) pulsed with a peptide derived from the tumor associated antigen human cancer-testis antigen NY-ESO-1 (NY-ESO-1(157-165)), with potential immunostimulatory and antineoplastic activities. Upon administration, the NY-ESO-1(157-165) peptide-pulsed autologous dendritic cell vaccine may stimulate the immune system to mount both an anti-tumoral cytotoxic T-lymphocyte (CTL)- and an antibody-mediated immune response against NY-ESO-1-expressing tumor cells, which may result in tumor cell lysis. NY-ESO-1 is expressed both in normal testes and on the surfaces of various tumor cells, and plays a key role in tumor cell proliferation and survival."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5216209", "l": "Erythrocytes.nucleated|NCnc|Pt|Synv fld", "d": []}]}
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{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5700419", "l": "Anti-BCMA-CAR-41BB-CD3zeta-expressing T-cells CT053", "d": []}]}
{"type": "biolink:Cell", "ic": "60.294437135382942", "identifiers": [{"i": "CL:0002092", "l": "bone marrow cell", "d": ["A cell found in the bone marrow. This can include fibroblasts, macrophages, adipocytes, osteoblasts, osteoclasts, endothelial cells and hematopoietic cells."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5166508", "l": "Hematopoietic progenitor cells | Blood | Hematology and Cell counts", "d": []}]}
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{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5554878", "l": "Single Cell Specimen", "d": []}, {"i": "NCIT:C178226", "l": "Single Cell Specimen", "d": ["A biospecimen that contains the contents of a single cell."]}]}
{"type": "biolink:Cell", "ic": "57.693390461713108", "identifiers": [{"i": "UMLS:C1516097", "l": "B lymphoblast", "d": []}, {"i": "NCIT:C33931", "l": "Precursor B-Lymphoblast", "d": ["A morphologically immature B-lymphocyte, once thought to represent an early stage in lymphocyte development but now known to be an activated lymphocyte that has been transformed in response to antigenic stimulation."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5216252", "l": "Lymphocytes|NCnc|Pt|Pericard fld", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5555029", "l": "Allogeneic CRISPR-edited Anti-CD19 CAR T Cells PBLTT52CAR19", "d": []}, {"i": "NCIT:C178434", "l": "Allogeneic CRISPR-edited Anti-CD19 CAR T Cells PBLTT52CAR19", "d": ["A preparation of allogeneic T-lymphocytes transduced with a lentiviral vector encoding a chimeric antigen receptor (CAR) specific for the tumor-associated antigen (TAA) CD19, with genetic modification of CD52 and T-cell receptor alpha constant (TRAC) loci via clustered regularly interspaced short palindromic repeats (CRISPR), with potential immunostimulating and antineoplastic activities. Upon administration, the allogeneic CRISPR-edited anti-CD19 CAR T cells PBLTT52CAR19 recognize and bind to CD19-overexpressing tumor cells. This may result in a specific cytotoxic T-lymphocyte (CTL)-mediated killing of CD19-positive tumor cells. CD19 antigen is a B-cell specific cell surface antigen expressed in all B-cell lineage malignancies. The editing of the CD52 gene may make the modified donor T-cells resistant to the anti-CD52 monoclonal antibody alemtuzumab, which is used during lymphodepletion. The editing of the TRAC may eliminate TCR expression, which may abrogate the potential induction of graft-versus-host disease (GvHD) by the donor T-cells, and may also result in uniform CAR expression and enhanced T-cell potency."]}]}
{"type": "biolink:Cell", "ic": "88.140761698499901", "identifiers": [{"i": "UMLS:C1510956", "l": "Atypical Histiocyte", "d": []}, {"i": "NCIT:C40999", "l": "Atypical Histiocyte", "d": []}]}
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{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5555045", "l": "Autologous Anti-CD19/Anti-CD20 CAR T Cells EXP039", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5184398", "l": "Unidentified cells | Pericardial fluid | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "ic": "89.347505587204751", "identifiers": [{"i": "UMLS:C1519986", "l": "Villous Lymphocyte", "d": []}, {"i": "NCIT:C38727", "l": "Villous Lymphocyte", "d": []}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "UMLS:C4284002", "l": "Type 1 Regulatory T-Cell", "d": []}, {"i": "NCIT:C126755", "l": "Type 1 Regulatory T-Cell", "d": ["A population of CD4+, CD25-, and FoxP3- T-lymphocytes that are involved in immunotolerance. These cells secrete the immunosuppressive cytokines, tumor growth factor-beta (TGF-B) and interleukin-10, and may induce cell cycle arrest or apoptosis in effector T-cells."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1440336", "l": "Cells.CD6", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1268001", "l": "Lymphocyte positive for CD126 antigen", "d": []}, {"i": "SNOMEDCT:117441008", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5555595", "l": "Allogeneic Anti-CD19 CAR T-cells PBCAR19B", "d": []}, {"i": "NCIT:C179301", "l": "Allogeneic Anti-CD19 CAR T-cells PBCAR19B", "d": ["A preparation of allogeneic T-lymphocytes that have been genetically modified to express a chimeric antigen receptor (CAR) targeting the tumor-associated antigen (TAA) CD19 (cluster of differentiation 19), a single short hairpin RNA (shRNA) that disrupts the expression of beta-2 microglobulin (B2M) component of the class 1 major histocompatibility complex (MHC) molecules, and a HLA-E gene, with potential immunostimulating and antineoplastic activities. Upon administration, the allogeneic anti-CD19 CAR T-cells PBCAR19B specifically recognize and bind to CD19-expressing tumor cells. This may result in a specific cytotoxic T-lymphocyte (CTL)-mediated killing of CD19-expressing tumor cells. The downregulation of the expression of the class 1 MHC molecule component B2M by shRNA and the HLA-E gene decrease the number of CAR T-cells that are rejected and killed by natural killer (NK) and cytotoxic T-cells. CD19 antigen is a B-cell specific cell surface antigen overexpressed in B-cell lineage malignancies."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C4727621", "l": "Autologous NY-ESO-1 TCR-targeted T Lymphocytes", "d": []}, {"i": "NCIT:C148150", "l": "Autologous NY-ESO-1 TCR-targeted T Lymphocytes", "d": ["A preparation of human autologous T-lymphocytes that are transduced with a gene encoding a T-cell receptor (TCR) specific for the cancer-testis antigen NY-ESO-1, with potential immunostimulating and antineoplastic activities. Upon isolation, transduction, expansion ex vivo, and reintroduction into the patient, the anti-NY-ESO-1 TCR-transduced autologous T-cells recognize and bind to NY-ESO-1-overexpressing tumor cells. This may result in a specific cytotoxic T-lymphocyte (CTL)-mediated killing of NY-ESO-1-positive tumor cells. NY-ESO-1, a tumor-associated antigen (TAA), is found in normal testis and on the surface of various tumor cell types, and is not, or is minimally, expressed in normal, healthy cells."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2362084", "l": "Washed packed erythrocytes", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1440410", "l": "Cells.t(21;22)(q22.3;q12.2)(ERG,EWSR1)", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1180242", "l": "Endothelial cell of artery", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002286", "l": "type II taste cell", "d": ["A taste receptor cell that has a short microvilli, a projecting apical region, a large rounded nucleus, and expresses taste chemoreceptors thus making them the transducing cell for taste qualities."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5667062", "l": "iPSC-derived Anti-BCMA CAR/CD16/IL-15RF-expressing CD38-eliminated NK Cells FT576", "d": []}, {"i": "NCIT:C186430", "l": "iPSC-derived Anti-BCMA CAR/CD16/IL-15RF-expressing CD38-eliminated NK Cells FT576", "d": ["An allogeneic, off-the-shelf, natural killer (NK) cell product derived from a clonal master induced pluripotent stem cell (iPSC) line, and engineered and multiplex-edited to express a chimeric antigen receptor (CAR) specific for the tumor-associated antigen (TAA) B-cell maturation antigen (BCMA; tumor necrosis factor receptor superfamily member 17; TNFRSF17), a high-affinity, non-cleavable CD16 (hnCD16) Fc receptor and a recombinant fusion of IL-15 and IL-15 receptor alpha (IL-15RF), and to eliminate CD38 expression, with potential immunostimulatory and antineoplastic activities. Upon administration, iPSC-derived anti-BCMA CAR/CD16/IL-15RF-expressing CD38-eliminated NK cells FT576 recognize, bind to and induce selective cytotoxicity in BCMA-expressing tumor cells, leading to tumor cell lysis and the release of tumor neoantigens. Additionally, FT576 NK cells secrete inflammatory cytokines and chemokines, thereby enhancing T-cell activity and recruitment to the tumor site. BCMA, a receptor for both a proliferation-inducing ligand (APRIL) and B-cell activating factor (BAFF), is a member of the tumor necrosis factor receptor superfamily (TNFRSF). BCMA is found on the surfaces of plasma cells, is overexpressed on malignant plasma cells and plays a key role in plasma cell proliferation and survival. IL-15RF promotes the survival of NK cells and enhances the cytotoxic effect of the NK cells and the activated anti-tumor T-cells. When used in combination with monoclonal antibodies, the hnCD16 Fc receptor of FT576 binds to the Fc portion of tumor cell-bound monoclonal antibodies, leading to NK cell activation, cytokine secretion and enhanced antibody-dependent cellular cytotoxicity (ADCC). CD16, also known as Fc-gamma receptor III, is normally expressed on the surface of NK cells, neutrophils, monocytes and macrophages, and plays a key role in initiating ADCC. It is often downregulated in certain cancers, thereby inhibiting the anti-tumor immune response. The lack of CD38 in FT576 NK cells prevents NK cell fratricide upon co-administration with a CD38-targeting monoclonal antibody as CD38 is normally expressed on the surface of activated NK cells. This enhances ADCC mediated by CD38-targeting monoclonal antibodies."]}]}
{"type": "biolink:Cell", "ic": "87.120474278337809", "identifiers": [{"i": "UMLS:C1708112", "l": "Fusiform Melanocyte", "d": []}, {"i": "NCIT:C54078", "l": "Fusiform Melanocyte", "d": []}]}
{"type": "biolink:Cell", "ic": "92.728541327098611", "identifiers": [{"i": "CL:0002480", "l": "nasal mucosa goblet cell", "d": ["A goblet cell located in the nasal epithelium."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5206851", "l": "Autologous Active IL-7 Receptor Co-expressing GD2-specific CAR T-cells", "d": []}, {"i": "NCIT:C162873", "l": "Autologous Active IL-7 Receptor Co-expressing GD2-specific CAR T-cells", "d": ["A preparation of autologous T-lymphocytes that have been genetically modified to express a chimeric antigen receptor (CAR) specific for the human tumor-associated antigen (TAA) GD2, and the constitutively active interleukin 7 (IL-7) receptor (C7R), with potential antineoplastic activity. Upon intravenous administration, autologous active IL-7 receptor co-expressing GD2-specific CAR T-cells target, bind to, and induce selective toxicity in GD2-expressing tumor cells. C7R triggers IL-7-mediated signaling that promotes T-cell proliferation, survival, and anti-tumor activity. GD2, a disialoganglioside and TAA, is overexpressed in a variety of tumor cell types."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0483191", "l": "cd4 and cd8+", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0000286", "l": "hyphal cell", "d": ["A cell of a filament of a fungal mycelium."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0000967", "l": "Bm5 B cell", "d": ["A memory B cell arising in the germinal center that is IgD-negative and has undergone somatic mutation of the variable region of the immunoglobulin heavy and light chain genes."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C0033731", "l": "Protoplasts", "d": []}, {"i": "NCIT:C12659", "l": "Protoplast", "d": ["A bacterial cell deprived of its cell wall, for example by growth in an isotonic medium in the presence of antibiotics that block synthesis of the wall peptidoglycan. Alternatively, a plant cell similarly deprived by enzymic treatment."]}, {"i": "MESH:D011523", "l": "Protoplasts", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5380747", "l": "Cells.CD21lowCD38-", "d": []}]}
{"type": "biolink:Cell", "ic": "63.169736408631259", "identifiers": [{"i": "CL:0000340", "l": "glioblast (sensu Nematoda and Protostomia)", "d": ["A precursor of the central nervous system that gives rise to glial cells only."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5216213", "l": "Erythrocytes|NCnc|Pt|Dial fld", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5669564", "l": "Nivadstrocel", "d": []}, {"i": "NCIT:C184825", "l": "Nivadstrocel", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5175150", "l": "Nucleated cells | Dialysis fluid | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "ic": "87.120474278337809", "identifiers": [{"i": "CL:0002090", "l": "polar body", "d": ["One of two small cells formed by the first and second meiotic division of oocytes."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4253013", "l": "Set of type F cells of pancreatic islet", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:2000033", "l": "limb basal cell of epidermis", "d": ["Any basal cell of epidermis that is part of a limb."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5175153", "l": "Nucleated cells | Pleural fluid | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157380", "l": "CD20 cells | XXX | Cell markers", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5175159", "l": "Nucleated erythrocytes | Cerebral spinal fluid | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "ic": "83.552982069901191", "identifiers": [{"i": "UMLS:C1883703", "l": "Large Melanoma Cell", "d": []}, {"i": "NCIT:C62400", "l": "Large Melanoma Cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0333799", "l": "Basket cell erythrocyte", "d": []}, {"i": "SNOMEDCT:54244009", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002108", "l": "CD38-negative IgG memory B cell", "d": ["A CD38-negative IgG memory B cell is a IgG-positive class switched memory B cell that has class switched and expresses IgG on the cell surface with the phenotype CD38-negative, IgD-negative, and IgG-positive."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:4023002", "l": "dynamic beta motor neuron", "d": ["A beta motor neuron that innervates the nuclear bag fibers of muscle spindles."]}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "UMLS:C1183500", "l": "Endodermal cell", "d": []}, {"i": "NCIT:C33932", "l": "Endoderm Cell", "d": ["An embryonic cell of the inner layer of three germ layers that forms the yolk sac and gives rise to the epithelium of the alimentary and respiratory tracts and the parenchyma of associated glands."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0086574", "l": "Lymphoid Cells", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C0028875", "l": "Odontoblasts", "d": []}, {"i": "NCIT:C12567", "l": "Odontoblast", "d": ["A cell derived from a preodontoblast that secretes predentin. Each odontoblast has a cytoplasmic extension, an odontoblastic process that traverses the thickness of the dentin and helps to maintain the dentin."]}, {"i": "MESH:D009804", "l": "Odontoblasts", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4484161", "l": "Cells.Ki-67 nuclear", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002037", "l": "CD2-positive, CD5-positive, CD44-positive alpha-beta intraepithelial T cell", "d": ["Intraepithelial T cells with a memory phenotype of CD2-positive, CD5-positive, and CD44-positive."]}]}
{"type": "biolink:Cell", "ic": "84.75972595860604", "identifiers": [{"i": "UMLS:C0018894", "l": "Helper-Inducer T-Lymphocyte", "d": []}, {"i": "NCIT:C12538", "l": "Helper-Inducer T-Lymphocyte", "d": ["A subtype of CD4+ T lymphocyte that triggers differentiation of nearby immune cells, and initiates a variety of other immune functions, including the induction of humoral and cellular inflammatory immune responses by B and other T lymphocytes, respectively."]}, {"i": "MESH:D006377", "l": "T-Lymphocytes, Helper-Inducer", "d": []}, {"i": "SNOMEDCT:29594005", "d": []}, {"i": "SNOMEDCT:7944005", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4697058", "l": "Predominant leukocyte", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C4733660", "l": "Total Tumor mRNA-pulsed Tumor-specific Ex vivo-expanded Autologous Lymphocyte Transfer Cells", "d": []}, {"i": "NCIT:C155969", "l": "Total Tumor mRNA-pulsed Tumor-specific Ex vivo-expanded Autologous Lymphocyte Transfer Cells", "d": ["A preparation of ex vivo expanded, autologous lymphocyte transfer cells (xALTs) that are loaded with total tumor RNA (TTRNA) derived from autologous tumor cells, with potential immunostimulatory and antineoplastic activities. Upon re-infusion of the TTRNA-loaded ALTs into the patient, these ALTs may elicit a highly specific cytotoxic T-lymphocyte (CTL) response against the tumor-associated antigens (TAAs) encoded by the TTRNA."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0945928", "l": "Cell positive for CD38 antigen", "d": []}, {"i": "SNOMEDCT:116827004", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2329053", "l": "Goblet cell of epithelium proper of jejunum", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0000918", "l": "Tc2 cell", "d": ["A CD8-positive, alpha-beta positive T cell expressing GATA-3 and secreting IL-4."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5216281", "l": "Mononuclear cells|NCnc|Pt|Plr fld", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0010013", "l": "type I pinealocyte", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0018043", "l": "Golgi-Mazzoni Corpuscles", "d": []}, {"i": "MESH:D006057", "l": "Golgi-Mazzoni Corpuscles", "d": []}, {"i": "SNOMEDCT:37419002", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0882904", "l": "Cells.CD57", "d": []}]}
{"type": "biolink:Cell", "ic": "92.728541327098611", "identifiers": [{"i": "CL:0002051", "l": "CD38-high pre-BCR positive cell", "d": ["A pre-BCR positive B cell that is CD38-high."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0009067", "l": "vacuolated fetal-type enterocyte", "d": ["An enterocyte found in the small intestine of newborn mammals and characterized by the presence of an apical canalicular system (ACS) leading to production of large vacuoles, important for colostral macromolecule uptake. After birth, the vacuolated fetal-type enterocytes are replaced with enterocytes lacking an ACS."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5417933", "l": "Allogeneic Anti-CD19 CAR T-cells ALLO-501A", "d": []}, {"i": "NCIT:C172708", "l": "Allogeneic Anti-CD19 CAR T-cells ALLO-501A", "d": ["A preparation of allogeneic, frozen, 'off-the-shelf', universal transcription activator-like effector nuclease (TALEN)-engineered, gene-edited T-lymphocytes expressing a chimeric antigen receptor (CAR) targeting the tumor-associated antigen (TAA) CD19, with potential immunostimulating and antineoplastic activities. Using TALEN technology, the T-cell receptor (TCR) alpha chain and CD52 genes are deleted from the CAR19 T-cells. Upon administration, allogeneic anti-CD19 CAR T-cells ALLO-501A specifically target and bind to CD19-expressing tumor cells, thereby selectively lysing CD19-expressing tumor cells. CD19 antigen is a B-cell specific cell surface antigen expressed in all B-cell lineage malignancies. Deletion of the CD52 gene makes the modified donor T-cells resistant to the anti-CD52 monoclonal antibody alemtuzumab, which is used during lymphodepletion. The knockout of the TCR alpha gene eliminates TCR expression and is intended to abrogate the potential induction of graft-versus-host disease (GvHD) by the donor T-cells. ALLO-501A lacks the rituximab recognition domains of ALLO-501."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1180239", "l": "Endothelial cell of Peyer's patch", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4319573", "l": "Clue cell", "d": []}, {"i": "SNOMEDCT:726573004", "d": []}]}
{"type": "biolink:Cell", "ic": "61.577164708155649", "identifiers": [{"i": "CL:0000210", "l": "photoreceptor cell", "d": ["A cell specialized to detect and transduce light."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4517923", "l": "Population of all round cells in portion of fluid", "d": []}, {"i": "SNOMEDCT:732289008", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C3176885", "l": "Blasts.cytoplasmic CD13", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1514078", "l": "Neoplastic Round Cell with Neuronal Differentiation", "d": []}, {"i": "NCIT:C37101", "l": "Neoplastic Round Cell with Neuronal Differentiation", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1979132", "l": "Blasts.CD127", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5179532", "l": "Reticulocytes.medium fluorescence/100 erythrocytes | Blood | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "ic": "52.537560559509892", "identifiers": [{"i": "UMLS:C1513019", "l": "Mature B-Lymphocyte", "d": []}, {"i": "NCIT:C33058", "l": "Mature B-Lymphocyte", "d": ["A descendant of a lymphoid stem cell that differentiates into either a plasma cell or a memory B cell in response to a specific antigen. The mature B lymphocyte develops and differentiates in the bone marrow."]}]}
{"type": "biolink:Cell", "ic": "77.712653754434029", "identifiers": [{"i": "CL:4023011", "l": "lamp5 GABAergic cortical interneuron", "d": ["A GABAergic neuron located in the cerebral cortex that expresses Lamp5"]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0004223", "l": "AB diffuse-1 amacrine cell", "d": ["A amacrine cell with a small dendritic field and post-synaptic terminals in S1, S2, S3, and S4. AB diffuse-1 amacrine cells have a tent-shaped dendritic arbor and undulate dendrites."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157427", "l": "CD3 cells | XXX | Cell markers", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5555826", "l": "Allogeneic Anti-CD7 CAR T Cells", "d": []}, {"i": "NCIT:C179630", "l": "Allogeneic Anti-CD7 CAR T Cells", "d": ["A preparation of donor-derived T-lymphocytes that have been genetically engineered to express a chimeric antigen receptor (CAR) directed against the tumor-associated antigen (TAA) CD7, with potential immunostimulating and antineoplastic activities. Upon intravenous administration, the allogeneic anti-CD7 CAR T cells specifically recognize and bind to CD7-expressing tumor cells, resulting in specific T-cell-mediated tumor cell lysis. CD7 is a transmembrane glycoprotein expressed by T-cells and natural killer (NK) cells and their precursors. It is expressed in the majority of lymphoblastic T-cell leukemias and lymphomas and in a subset of peripheral T-cell lymphomas."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1513964", "l": "Neoplastic Fasciculata Cell", "d": []}, {"i": "NCIT:C36926", "l": "Neoplastic Fasciculata Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "92.728541327098611", "identifiers": [{"i": "UMLS:C1514090", "l": "Neoplastic Small Mature Neuroepithelial Cell", "d": []}, {"i": "NCIT:C41837", "l": "Neoplastic Small Mature Neuroepithelial Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "92.728541327098611", "identifiers": [{"i": "CL:0000866", "l": "thymic macrophage", "d": ["A tissue-resident macrophage resident found in the thymus, involved in the clearance of apoptotic thymocytes."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5703312", "l": "Anti-Immunoglobulin-beta CAR T Cells", "d": []}, {"i": "NCIT:C187298", "l": "Anti-Immunoglobulin-beta CAR T Cells", "d": ["A preparation of T-lymphocytes that are genetically engineered to express a chimeric antigen receptor (CAR) targeting immunoglobulin-beta (Igb), with potential immunostimulating and antineoplastic activities. Upon administration, the anti-Igb CAR T cells are directed to, specifically bind to, and induce selective toxicity in Igb antigen-expressing tumor cells."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1267997", "l": "Lymphocyte positive for CD118 antigen", "d": []}, {"i": "SNOMEDCT:117437009", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4740237", "l": "Spermatozoa.abnormal principal pieces", "d": []}]}
{"type": "biolink:Cell", "ic": "88.140761698499901", "identifiers": [{"i": "CL:0000962", "l": "Bm2 B cell", "d": ["A follicular B cell that is IgD-positive and CD23-positive and CD38-positive. This naive cell type is activated in the extrafollicular areas via interaction with dendritic cells and antigen specific T cells."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0000713", "l": "corona radiata cell", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0004227", "l": "flat bistratified amacrine cell", "d": ["A bistratified amacrine cell with a small dendritic field. Flat bistratified amacrine cells have post-synaptic terminals both on the border of S1 and S2, and on the border of S3 and S4. This cell type releases the neurotransmitter glycine."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5706462", "l": "Autologous Anti-BCMA CAR T-cells MCARH125", "d": []}, {"i": "NCIT:C188226", "l": "Autologous Anti-BCMA CAR T-cells MCARH125", "d": ["A preparation of autologous T-lymphocytes that have been genetically engineered to express a chimeric antigen receptor (CAR) targeting the human tumor-associated antigen (TAA) B-cell maturation antigen (BCMA; tumor necrosis factor receptor superfamily member 17; TNFRSF17), with potential antineoplastic activity. Upon administration, the autologous anti-BCMA CAR T-cells MCARH125 recognize and induce selective toxicity against BCMA-expressing tumor cells. BCMA, a tumor-specific antigen and a receptor for both a proliferation-inducing ligand (APRIL) and B-cell activating factor (BAFF), is a member of the tumor necrosis factor receptor superfamily (TNFRSF) and plays a key role in plasma cell survival. BCMA is found on the surfaces of plasma cells and is overexpressed on malignant plasma cells."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C3831434", "l": "Autologous Mesenchymal Stem Cells Apceth_101", "d": []}, {"i": "NCIT:C113803", "l": "Autologous Mesenchymal Stem Cells Apceth_101", "d": ["Human autologous mesenchymal stem cells (MSCs) harvested from the bone marrow of a patient and genetically modified with a self-inactivating retroviral vector expressing the suicide gene herpes simplex virus thymidine kinase (HSV-TK), that can be used to activate synthetic acyclic guanosine analogues when co-administered. Upon intravenous administration of autologous mesenchymal stem cells apceth_101, the cells are actively recruited to the tumor stroma, differentiate into more mature mesenchymal cells, and become part of the tumor microenvironment. When a synthetic acyclic guanosine analogue, such as ganciclovir, is co-administered, the HSV-TK within the HSV-TK-transduced MSCs will monophosphorylate this prodrug. Subsequently the monophosphate form is further converted to the diphosphate form and then to its active triphosphate form by cellular kinases. The active form of ganciclovir kills the HSV-TK-transduced MSCs and leads to a bystander effect, which eliminates neighboring cancer cells. Therefore, synthetic acyclic guanosine analogues are activated only at the tumor site, which increases their local efficacy and reduces systemic toxicity."]}]}
{"type": "biolink:Cell", "ic": "88.140761698499901", "identifiers": [{"i": "UMLS:C1513985", "l": "Neoplastic Histiocyte-Like Cell", "d": []}, {"i": "NCIT:C36961", "l": "Neoplastic Histiocyte-Like Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C4329671", "l": "Circulating Tumor-Reactive T-Cell", "d": []}, {"i": "NCIT:C131128", "l": "Circulating Tumor-Reactive T-Cell", "d": ["A population of T-lymphocytes that can mount an immune response against circulating tumor cells. These cells may spontaneously arise as a response to the presence of either endogenous tumor antigens or exogenous tumor antigens administered as a cancer vaccine."]}]}
{"type": "biolink:Cell", "ic": "58.960274998691524", "identifiers": [{"i": "UMLS:C3496194", "l": "Epidermal cells", "d": []}, {"i": "NCIT:C32271", "l": "Cell of the Epidermis", "d": ["An epithelial cell of the outer most layer of the skin."]}, {"i": "MESH:D000078404", "l": "Epidermal Cells", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2335377", "l": "Set of cholinergic cells of accumbens nucleus [Ch3]", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:1000479", "l": "Purkinje myocyte of atrioventricular node", "d": ["A Purkinje myocyte that is part of the atrioventricular node."]}]}
{"type": "biolink:Cell", "ic": "90.82444074280258", "identifiers": [{"i": "CL:0000452", "l": "thyroid hormone secreting cell", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002409", "l": "mature Vgamma2-negative thymocyte", "d": ["A thymocyte that has a T cell receptor consisting of a gamma chain that does not contain the Vgamma2 segment, and a delta chain. This cell type is CD4-negative, CD8-negative and CD24-negative."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002390", "l": "uninucleate blastconidium", "d": ["A blastoconidium that has only one nucleus."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4038497", "l": "Cells.aneuploid.G2 phase population", "d": []}]}
{"type": "biolink:Cell", "ic": "80.511444690059548", "identifiers": [{"i": "CL:0000313", "l": "serous secreting cell", "d": ["Columnar glandular cell with irregular nucleus, copious granular endoplasmic reticulum and supranuclear granules. Secretes a watery fluid containing proteins known as serous fluid."]}]}
{"type": "biolink:Cell", "ic": "81.648881485605159", "identifiers": [{"i": "UMLS:C1514178", "l": "Pleomorphic Reed-Sternberg Cell", "d": []}, {"i": "NCIT:C38423", "l": "Pleomorphic Reed-Sternberg Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C0229216", "l": "Amacrine Cells", "d": []}, {"i": "NCIT:C12626", "l": "Amacrine Cell", "d": ["A retinal neuron that lacks large axons, having only processes that resemble dendrites."]}, {"i": "MESH:D025042", "l": "Amacrine Cells", "d": []}, {"i": "SNOMEDCT:9475001", "d": []}]}
{"type": "biolink:Cell", "ic": "92.728541327098611", "identifiers": [{"i": "CL:0002018", "l": "CD71-negative, GlyA-positive orthochromatic erythroblast", "d": ["An erythroblast that is GlyA-positive and CD71-negative."]}]}
{"type": "biolink:Cell", "ic": "84.128890093485552", "identifiers": [{"i": "CL:0002050", "l": "fraction C' precursor B cell", "d": ["A pre-BCR-positive precursor B cell that is CD24-high, CD25-positive, CD43-positive, CD45R-positive and BP-positive."]}]}
{"type": "biolink:Cell", "ic": "80.17194633000733", "identifiers": [{"i": "CL:0002432", "l": "CD24-positive, CD4 single-positive thymocyte", "d": ["A CD4-positive, CD8-negative thymocyte that is CD24-positive and expresses high levels of the alpha-beta T cell receptor."]}]}
{"type": "biolink:Cell", "ic": "75.26123597683771", "identifiers": [{"i": "UMLS:C1513992", "l": "Neoplastic Intermediate Type Trophoblastic Cell", "d": []}, {"i": "NCIT:C37142", "l": "Neoplastic Intermediate Type Trophoblastic Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "82.532694649739099", "identifiers": [{"i": "UMLS:C1881543", "l": "Malignant Eccrine Cell", "d": []}, {"i": "NCIT:C62499", "l": "Malignant Eccrine Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002120", "l": "CD24-positive CD38-negative IgG-negative class switched memory B cell", "d": ["An CD24-positive CD38-negative IgG-negative memory B cell is a CD38-negative IgG-negative class switched memory B cell that lacks IgG on the cell surface with the phenotype CD24-positive, CD38-negative, and IgG-negative."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002554", "l": "fibroblast of lymphatic vessel", "d": ["A fibroblast of the lymphatic system."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5216308", "l": "Platelets|NCnc|Pt|BldCo", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1514739", "l": "Reactive mesothelial cells", "d": []}, {"i": "NCIT:C36830", "l": "Reactive Mesothelial Cell", "d": []}, {"i": "SNOMEDCT:447003004", "d": []}]}
{"type": "biolink:Cell", "ic": "72.683459462529498", "identifiers": [{"i": "CL:0000103", "l": "bipolar neuron", "d": ["A type of interneuron that has two neurites, usually an axon and a dendrite, extending from opposite poles of an ovoid cell body."]}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "CL:0000890", "l": "alternatively activated macrophage", "d": ["An elicited macrophage characterized by low production of pro-inflammatory and Th1 polarizing cytokines and high expression of arginase-1, and associated with tissue remodelling."]}]}
{"type": "biolink:Cell", "ic": "83.552982069901191", "identifiers": [{"i": "CL:4023062", "l": "dentate gyrus neuron", "d": ["A neuron with its soma located in the dentate gyrus of the hippocampus."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5221012", "l": "Platelets.reticulated|NCnc|Pt|Bld", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1517738", "l": "Large Round Epithelioid Endothelial Cell", "d": []}, {"i": "NCIT:C37094", "l": "Large Round Epithelioid Endothelial Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:1000371", "l": "transitional myocyte of right branch of atrioventricular bundle", "d": ["A transitional myocyte that is part of the right branch of atrioventricular bundle."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5427571", "l": "Cones.right", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5180941", "l": "Siderocytes | Blood | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0004121", "l": "retinal ganglion cell B2", "d": ["A retinal ganglion cell B that has a very small but very dense dendritic field, and has post synaptic terminals in S2."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4246476", "l": "Ectomesenchymal cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4304497", "l": "Population of all dacryocytes in portion of fluid", "d": []}, {"i": "SNOMEDCT:719691002", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4277646", "l": "Place Cells", "d": []}, {"i": "MESH:D000071037", "l": "Place Cells", "d": []}]}
{"type": "biolink:Cell", "ic": "90.82444074280258", "identifiers": [{"i": "CL:1001436", "l": "hair-tylotrich neuron", "d": ["The subcutaneous mechanoreceptors that innervate tylotrich hair follicles."]}]}
{"type": "biolink:Cell", "ic": "75.751739371353352", "identifiers": [{"i": "CL:0000385", "l": "prohemocyte (sensu Nematoda and Protostomia)", "d": ["A precursor of mature hemocytes."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1440141", "l": "Blasts.CD13", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0009082", "l": "committed double negative thymocyte (Homo sapiens)", "d": ["The human equivalent of a DN3 thymocyte; these thymocytes finish the process of beta selection."]}]}
{"type": "biolink:Cell", "ic": "84.75972595860604", "identifiers": [{"i": "UMLS:C1512993", "l": "Marginal Zone B-Lymphocyte of Nodal Type", "d": []}, {"i": "NCIT:C38322", "l": "Marginal Zone B-Lymphocyte of Nodal Type", "d": ["A lymphocyte found in the marginal zones of lymph nodes. It has a naive B lymphoid lineage and plays an important role in the early phases of immune response with its ability to rapidly differentiate into an antibody secreting cell. These cells can directly activate T cells, interact with other antigen presenting cells, transporting and concentrating antigen during the course of T-dependent and T-independent immune responses."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157394", "l": "CD22 blasts | Bone marrow | Cell markers", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002566", "l": "dark melanocyte", "d": ["A melanocyte that appears darker due to content or amount of melanin granules."]}]}
{"type": "biolink:Cell", "ic": "86.236661114203869", "identifiers": [{"i": "CL:1000458", "l": "melanocyte of skin", "d": ["A melanocyte that is part of the skin of body."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C4727036", "l": "Autologous Anti-CD19 CAR-CD3zeta-4-1BB-expressing T-cells PZ01", "d": []}, {"i": "NCIT:C153118", "l": "Autologous Anti-CD19 CAR-CD3zeta-4-1BB-expressing T-cells PZ01", "d": ["A preparation of autologous T-lymphocytes that have been transduced with a lentiviral vector to express a chimeric antigen receptor (CAR) consisting of a single chain variable fragment (scFv) of anti-CD19, coupled to the costimulatory domains of 4-1BB (CD137) and the zeta chain of the human T-cell receptor (CD3zeta), with potential immunostimulating and antineoplastic activities. Upon transfusion, the autologous anti-CD19 CAR-CD3zeta-4-1BB-expressing T-cells PZ01 target, bind to, and induce selective toxicity in CD19-expressing B cells. The CD19 antigen is a B-cell-specific cell surface antigen expressed in all B-cell lineage malignancies."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2331711", "l": "Blue cone bipolar cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5571776", "l": "Cells.CD19+FMC7+", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C3273000", "l": "Allogeneic CD56-positive CD3-negative Natural Killer Cells", "d": []}, {"i": "NCIT:C96741", "l": "Allogeneic CD56-positive CD3-negative Natural Killer Cells", "d": ["A population of allogeneic lymphocytes expressing the CD56 surface antigen and exhibiting a lack of CD3, with immunomodulating activity. Upon infusion of allogeneic CD56-positive CD3-negative natural killer (NK) cells, these cells are able to secrete cytokines and recognize and kill tumor cells as well as virally-infected cells. CD56 is a transmembrane glycoprotein also known as NCAM (Neural Cell Adhesion Molecule)."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5216255", "l": "Lymphocytes|NCnc|Pt|Synv fld", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5238118", "l": "Adimlecleucel", "d": []}, {"i": "NCIT:C166763", "l": "Adimlecleucel", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5171865", "l": "Macrophages | Cerebral spinal fluid | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1510962", "l": "Atypical Parabasal Cell", "d": []}, {"i": "NCIT:C36787", "l": "Atypical Parabasal Cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C3656573", "l": "Cells.CD3-CD8-CD57+", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5172506", "l": "Mesothelial cells | Peritoneal fluid | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "ic": "92.728541327098611", "identifiers": [{"i": "CL:0010022", "l": "cardiac neuron", "d": ["A neuron that has its soma in the heart."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4511515", "l": "Reticulocyte specimen", "d": []}, {"i": "SNOMEDCT:725946000", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1979675", "l": "Cells.CD56+CD57+", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002510", "l": "CD103-negative, langerin-positive lymph node dendritic cell", "d": ["A langerin-positive lymph node dendritic cell that is CD103-negative and CD11b-high."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002424", "l": "DN2b thymocyte", "d": ["A DN2 thymocyte that is Kit-low."]}]}
{"type": "biolink:Cell", "ic": "65.929933841797123", "identifiers": [{"i": "UMLS:C0004112", "l": "Astrocytes", "d": []}, {"i": "NCIT:C12477", "l": "Astrocyte", "d": ["A heterogeneous group of specialized neuroglial cells with many diverse supporting roles in the structure, function, and homeostasis of the central nervous system."]}, {"i": "MESH:D001253", "l": "Astrocytes", "d": []}, {"i": "SNOMEDCT:78399007", "d": []}]}
{"type": "biolink:Cell", "ic": "76.46797986554256", "identifiers": [{"i": "UMLS:C1510722", "l": "Abnormal Erythroblast", "d": []}, {"i": "NCIT:C37057", "l": "Abnormal Erythroblast", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0011027", "l": "skeletal muscle fibroblast", "d": ["Any fibroblast that is part of skeletal muscle tissue."]}]}
{"type": "biolink:Cell", "ic": "89.347505587204751", "identifiers": [{"i": "CL:0000989", "l": "CD11c-low plasmacytoid dendritic cell", "d": ["CD11c-low plasmacytoid dendritic cell is a leukocyte that is CD11c-low, CD45R-positive, GR1-positive and CD11b-negative."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0000691", "l": "stellate interneuron", "d": []}]}
{"type": "biolink:Cell", "ic": "90.82444074280258", "identifiers": [{"i": "CL:1000505", "l": "kidney pelvis cell", "d": []}]}
{"type": "biolink:Cell", "ic": "77.061101857006449", "identifiers": [{"i": "CL:0005026", "l": "hepatoblast", "d": ["Multi fate stem cell that gives rise to both hepatocytes and cholangiocytes as descendants. The term often refers to fetal precursors of hepatocytes (differently from 'hepatic stem cell', usually applied to the self-renewing pool of hepatocyte precursors in the adult liver). Hepatoblasts may also be endogenous, as some stem cells found in the liver come from the bone marrow via blood circulation."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2336252", "l": "Type 2A muscle fiber", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0000944", "l": "Be2 cell", "d": ["A Be cell that facilitates development of T-helper 2 (Th2) phenotype T cells, and secretes high levels of interleukin-2, interleukin-10, interleukin-4, and interleukin-6."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4086001", "l": "lisocabtagene maraleucel", "d": []}, {"i": "SNOMEDCT:1148744000", "d": []}, {"i": "SNOMEDCT:1148950000", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:4023080", "l": "stellate L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (Mmus)", "d": ["a L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex that has stellate pyramidal morphology."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0882814", "l": "Cell positive for CD2 antigen", "d": []}, {"i": "SNOMEDCT:732268004", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5420488", "l": "Allogeneic Anti-BCMA/CS1 Bispecific CAR-T Cells", "d": []}, {"i": "NCIT:C173967", "l": "Allogeneic Anti-BCMA/CS1 Bispecific CAR-T Cells", "d": ["A preparation of allogeneic T-lymphocytes that have been genetically modified to express a chimeric antigen receptor (CAR) targeting both the tumor-associated antigens (TAAs) B-cell maturation antigen (BCMA; TNFRSF17) and human CS1 (CD2 subset 1; SLAM family member 7; SLAMF7; CD319; CRACC), with potential immunomodulating and antineoplastic activities. Upon administration, the allogeneic anti-BCMA/CS1 bispecific CAR-T cells target and bind to tumor cells expressing BCMA and/or CS1 and induce selective cytotoxicity in those cells. BCMA, a receptor for both a proliferation-inducing ligand (APRIL) and B-cell activating factor (BAFF), is a member of the tumor necrosis factor receptor superfamily (TNFRSF). BCMA is found on the surfaces of plasma cells, is overexpressed on malignant plasma cells and plays a key role in plasma cell proliferation and survival. SLAMF7 is a member of the signaling lymphocytic activation molecule (SLAM) family of transmembrane receptors that modulate the function of immune cells through immunoreceptor tyrosine-based switch motifs (ITSMs) and intracellular adaptor proteins. SLAMF7 is highly expressed on certain malignant plasma cells and is minimally expressed on healthy immune cells. Targeting the two different TAAs highly expressed on malignant plasma cells may improve coverage and protect against antigen escape and resistance as tumor cells would need to lose both antigens."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5417845", "l": "Autologous Clonal Neoantigen T Cells ATL001", "d": []}, {"i": "NCIT:C171097", "l": "Autologous Clonal Neoantigen T Cells ATL001", "d": ["A preparation of personalized tumor-derived T-lymphocytes composed of tumor infiltrating lymphocytes (TILs) that are reactive to clonal cancer neoantigens, with potential immunostimulating and antineoplastic activities. The TILs are removed from the suppressive tumor microenvironment (TME) and re-activated. Upon reintroduction into the patient, the clonal neoantigen T (cNeT) cells recognize and bind to tumor cells expressing the targeted neoantigen, resulting in a cytotoxic T-lymphocyte (CTL)-mediated immune response against the patient's tumor cells."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0003007", "l": "G4-OFF retinal ganglion cell", "d": ["A G4 retinal ganglion cell that has post sympatic terminals in sublaminar layers S2 and S3 and is depolarized by decreased illumination of their receptive field center"]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4266481", "l": "Tc-99m tagged RBC", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1182619", "l": "Epithelial cell of lacrimal sac", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157358", "l": "CD19+CD38+IgM+ cells | Blood | Cell markers", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1440359", "l": "Cells.CD80", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5380995", "l": "Cells.CD8.HLA-B7 CMV specific.CMV antigen stimulated gamma interferon producing", "d": []}]}
{"type": "biolink:Cell", "ic": "67.152088137740293", "identifiers": [{"i": "CL:0000835", "l": "myeloblast", "d": ["The most primitive precursor in the granulocytic series, having fine, evenly distributed chromatin, several nucleoli, a high nuclear-to-cytoplasmic ration (5:1-7:1), and a nongranular basophilic cytoplasm. They reside in the bone marrow."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5446774", "l": "Nalotimagene Carmaleucel", "d": []}, {"i": "NCIT:C175827", "l": "Nalotimagene Carmaleucel", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:1000718", "l": "kidney inner medulla collecting duct principal cell", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C4725100", "l": "Autologous CD22-4SCAR-expressing T-cells 4SCAR22", "d": []}, {"i": "NCIT:C148524", "l": "Autologous CD22-4SCAR-expressing T-cells 4SCAR22", "d": ["A preparation of genetically modified autologous T-cells transduced with a replication incompetent, self-inactivating lentiviral vector expressing a  fourth generation chimeric antigen receptor (4SCAR) consisting of an anti-CD22 single chain variable fragment (scFv) that is coupled to the costimulatory signaling domains CD28, CD137, CD27 and the zeta chain of the T-cell receptor (TCR), and is fused with the suicide gene inducible caspase 9 (iCasp9), with potential immunostimulating and antineoplastic activities. Upon intravenous administration, autologous CD22-4SCAR-expressing T-cells 4SCAR22 are directed to and induce selective toxicity in CD22-expressing tumor cells. iCasp9 consists of a human FK506 drug-binding domain with an F36V mutation (FKBP12-F36V) linked to human caspase 9. If the administered T-cells lead to unacceptable side effects, the chemical homodimerizer AP1903 can be administered. AP1903 binds to the drug binding FKBP12-F36V domain and induces activation of caspase 9, which results in the apoptosis of the administered T-cells and enhances safety of this agent. CD22, a B-lineage-restricted, transmembrane phosphoglycoprotein, is expressed on malignant B cells. CD28, CD137 and CD27, T-cell surface-associated co-stimulatory molecules, are required for full T-cell activation and enhance both proliferation of T-cells and antitumor activity."]}]}
{"type": "biolink:Cell", "ic": "82.532694649739099", "identifiers": [{"i": "CL:0000899", "l": "T-helper 17 cell", "d": ["CD4-positive, alpha-beta T cell with the phenotype RORgamma-t-positive, CXCR3-negative, CCR6-positive, and capable of producing IL-17."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5216318", "l": "Reticulocytes|NCnc|Pt|Bld", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0432610", "l": "Giant metamyelocyte", "d": []}, {"i": "SNOMEDCT:259711002", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C3900004", "l": "Autologous CD171-specific CAR-CD28 zeta-4-1-BB-EGFRt-expressing T Lymphocytes", "d": []}, {"i": "NCIT:C119746", "l": "Autologous CD171-specific CAR-CD28 zeta-4-1-BB-EGFRt-expressing T Lymphocytes", "d": ["A preparation of genetically modified autologous human T-lymphocytes transduced with a lentiviral vector expressing a chimeric antigen receptor (CAR) specific for the L1 cell adhesion molecule (L1-CAM/CD171) antigen, and the co-stimulatory signaling domains CD28, 4-1BB (CD137) and CD3 zeta, and a truncated form of the human epidermal growth factor receptor (EGFRt), with potential immunostimulating and antineoplastic activities. Upon re-infusion into the patient, the autologous L1-CAM-specific CAR-CD28 zeta-4-1-BB-EGFRt-expressing T-lymphocytes are directed to and induce selective toxicity in L1-CAM-expressing tumor cells. L1-CAM, a neuronal cell adhesion molecule and member of the L1 protein family, plays a key role in the development of the nervous system; it is overexpressed in various tumor cell types and is associated with increased chemoresistance, tumor progression, migration and metastasis. Devoid of both ligand-binding domains and tyrosine kinase activity, EGFRt facilitates both the detection of the administered T-cells in vivo and the elimination of the modified T-cells following a cetuximab-induced antibody-dependent cellular cytotoxicity (ADCC) response. The co-stimulatory signaling domains enhance both proliferation of T-cells and antitumor activity."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0010001", "l": "stromal cell of bone marrow", "d": ["A stromal cell that is part_of a bone marrow."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1267929", "l": "Lymphocyte positive for both CD45 antigen and CD14 antigen", "d": []}, {"i": "SNOMEDCT:117372008", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0000321", "l": "seminal fluid secreting cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1182645", "l": "Ciliary epithelial cell", "d": []}]}
{"type": "biolink:Cell", "ic": "86.236661114203869", "identifiers": [{"i": "UMLS:C1709204", "l": "Neoplastic Spindle-Shaped Adipocyte", "d": []}, {"i": "NCIT:C48907", "l": "Neoplastic Spindle-Shaped Adipocyte", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5173496", "l": "Mononuclear cells | Dialysis fluid peritoneal | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5163445", "l": "Eosinophils | Sputum | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "ic": "63.588454143880355", "identifiers": [{"i": "CL:0000287", "l": "eye photoreceptor cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5180436", "l": "Schistocytes | Blood | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1267839", "l": "Lymphocyte negative for CD3 antigen and positive for both CD16 antigen and CD56 antigen", "d": []}, {"i": "SNOMEDCT:116730000", "d": []}]}
{"type": "biolink:Cell", "ic": "84.128890093485552", "identifiers": [{"i": "CL:0008047", "l": "intrafusal muscle fiber", "d": ["A skeletal muscle fiber that is part of a muscle spindle. These are specialized muscle fibers that serve as proprioceptors, detecting the amount and rate of change in length of a muscle. They are innervated by both sensory neurons and motor neurons (gamma and beta motorneurons, collectively referred to as fusimotor neurons)."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002615", "l": "adipocyte of omentum tissue", "d": ["A fat cell that is part of omentum tissue."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2329620", "l": "Regular interatrial cardiac myocyte", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002567", "l": "light melanocyte", "d": ["A melanocyte that appears lighter in color."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5557367", "l": "Allogeneic Human Stem Cell-derived Pancreatic Islet Cells VX-880", "d": []}, {"i": "NCIT:C181923", "l": "Allogeneic Human Stem Cell-derived Pancreatic Islet Cells VX-880", "d": ["A preparation of allogeneic human stem cell-derived, fully differentiated functional pancreatic islet cells, that can be used for islet cell transplantation for the treatment of type 1 diabetes mellitus. Upon infusion into the hepatic portal vein, allogeneic human stem cell-derived pancreatic islet cells VX-880 may replace and restore pancreatic islet cells, which are destroyed in patients with type 1 diabetes. These cells may restore pancreatic islet cell function, produce insulin and may regulate blood glucose levels."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5417771", "l": "Viralym-M", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5154514", "l": "Basophils+Eosinophils+Monocytes | Blood | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157383", "l": "CD20+FMC7+ cells | Body fluid | Cell markers", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157612", "l": "CD55 Monocytes | Blood | Cell markers", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157668", "l": "CD8+CD28+ cells | Blood | Cell markers", "d": []}]}
{"type": "biolink:Cell", "ic": "64.931672288613356", "identifiers": [{"i": "CL:0000855", "l": "sensory hair cell", "d": ["Hair cell is a mechanoreceptor cell that is sensitive to movement of the hair-like projections (stereocilia and kinocilia) which relay the information centrally in the nervous system."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1317193", "l": "Cells.CD23+CD38+", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1441322", "l": "Viable cells", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157924", "l": "Cells | Pleural fluid | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0483193", "l": "CD7+CD3-", "d": []}]}
{"type": "biolink:Cell", "ic": "83.023198044254755", "identifiers": [{"i": "UMLS:C1710150", "l": "Spindle A Melanoma Cell", "d": []}, {"i": "NCIT:C54158", "l": "Spindle A Melanoma Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "90.82444074280258", "identifiers": [{"i": "CL:0008016", "l": "activated skeletal muscle satellite cell", "d": ["A skeletal muscle satellite cell that has become mitotically active - typically following muscle damage."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1267872", "l": "Lymphocyte positive for CD13 antigen", "d": []}, {"i": "SNOMEDCT:117551006", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002297", "l": "type-3 epithelial cell of thymus", "d": ["A thymic epithelial cell with moderate nuclear and cytoplasmic electron-density. Scattered in the cortex, this cell type is predominant in the mid and deep cortex."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2336894", "l": "Goblet cell of epithelium proper of appendix", "d": []}]}
{"type": "biolink:Cell", "ic": "86.236661114203869", "identifiers": [{"i": "CL:1000481", "l": "transitional myocyte of atrioventricular bundle", "d": ["A transitional myocyte that is part of the atrioventricular bundle."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1267947", "l": "Lymphocyte positive for CD55 antigen", "d": []}, {"i": "SNOMEDCT:117390009", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002100", "l": "regular interventricular cardiac myocyte", "d": ["A regular cardiac myocyte of the interventricular region of the heart."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4267791", "l": "Cells.CD27+CD45RA-", "d": []}]}
{"type": "biolink:Cell", "ic": "89.347505587204751", "identifiers": [{"i": "CL:0002128", "l": "Tc17 cell", "d": ["A CD8-positive, alpha-beta T cell that has the phenotype CXCR3-negative, CCR6-positive, CCR5-high, CD45RA-negative, and capable of producing IL-17 and some IFNg."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C4086612", "l": "Multi-glioblastoma-peptide-targeting Autologous Dendritic Cell Vaccine ICT-107", "d": []}, {"i": "NCIT:C124054", "l": "Multi-glioblastoma-peptide-targeting Autologous Dendritic Cell Vaccine ICT-107", "d": ["A cell-based cancer vaccine composed of autologous dendritic cells (DCs) pulsed with six synthetic glioblastoma (GBM) peptides: absent in melanoma 2 (AIM-2), melanoma-associated antigen 1 (MAGE-1), tyrosinase-related protein 2 (TRP-2), glycoprotein 100 (gp100), epidermal growth factor receptor 2 (HER-2), interleukin-13 receptor subunit alpha-2 (IL-13Ra2), with potential immunostimulatory and antineoplastic activities. Mononuclear cells obtained via leukapheresis are differentiated into DCs, and pulsed with the GBM-associated peptides. Upon administration, multi-glioblastoma-peptide-targeting autologous DC vaccine ICT-107 exposes the immune system to GBM-associated antigens, which activates a specific cytotoxic T-lymphocyte (CTL) response against GBM cells. This leads to GBM cell lysis. The six peptides are derived from tumor associated antigens (TAA) expressed on GBM cells and cancer stem cells (CSCs). GBM stem-like cells contain a specific range of antigens that are essential for the neoplastic growth and survival of GBM cells."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0041362", "l": "Tumor Cells, Cultured", "d": []}, {"i": "MESH:D014407", "l": "Tumor Cells, Cultured", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:1000331", "l": "serous cell of epithelium of bronchus", "d": ["A serous secreting cell that is part of the epithelium of bronchus."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5669570", "l": "Etuvetidigene Autotemcel", "d": []}, {"i": "NCIT:C184832", "l": "Etuvetidigene Autotemcel", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1515168", "l": "TNF Transduced TIL", "d": []}, {"i": "NCIT:C29482", "l": "TNF Transduced TIL", "d": ["A preparation of autologous tumor-infiltrating lymphocytes (TILs) that have been transduced with a retroviral vector encoding the gene for tumor necrosis factor (TNF), a cytokine with anti-angiogenic and cytotoxic activity.  Following genetic modification, the lymphocytes are returned to the patient, infiltrate the tumor site, and deliver TNF directly to the tumor site, thereby exerting a specific antitumor effect, and avoiding TNF-related systemic toxicity. (NCI04)"]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0229423", "l": "Mastoid cells", "d": []}, {"i": "SNOMEDCT:57222008", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4324113", "l": "CD38+ T lymphocyte", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5447312", "l": "Autologous Tolerogenic Proinsulin Peptide-loaded Dendritic Cells PIpepTolDC", "d": []}, {"i": "NCIT:C176573", "l": "Autologous Tolerogenic Proinsulin Peptide-loaded Dendritic Cells PIpepTolDC", "d": ["A vaccine composed of autologous tolerogenic dendritic cells (DCs) loaded with the beta cell protein proinsulin peptide (PIpep), C19-A3, with potential immunosuppressive and immune-regulating activities. Upon intradermal administration, the autologous tolerogenic PIpep-loaded DCs may induce proinsulin-specific regulatory T-cells (Tregs). This may suppress the autoimmune destruction of the insulin-producing beta cells, thereby protecting the beta cells."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2332614", "l": "Transitional myocyte of left branch of atrioventricular bundle", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4038488", "l": "Cervical cells.overexpressing HPV E6+E7 mRNA", "d": []}]}
{"type": "biolink:Cell", "ic": "78.96520244130248", "identifiers": [{"i": "CL:0000845", "l": "marginal zone B cell of spleen", "d": ["A mature B cell that is located in the marginal zone of the spleen with the phenotype CD23-negative and CD21-positive and expressing a B cell receptor usually reactive to bacterial cell wall components or senescent self components such as oxidized-LDL. This cell type is also described as being CD19-positive, B220-positive, IgM-high, AA4-negative, CD35-high."]}]}
{"type": "biolink:Cell", "ic": "88.140761698499901", "identifiers": [{"i": "UMLS:C1518985", "l": "Perineurial Cell", "d": []}, {"i": "NCIT:C41442", "l": "Perineurial Cell", "d": ["A cell that belongs to the supporting tissue surrounding a nerve fiber bundle. It has thin long bipolar cytoplasmic processes, pinocytotic vesicles, fragments of external lamina and/or external lamina-like material, attachment plaques, and desmosome-like junctions."]}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "UMLS:C1514094", "l": "Neoplastic Small T-Prolymphocyte", "d": []}, {"i": "NCIT:C39571", "l": "Neoplastic Small T-Prolymphocyte", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1267803", "l": "FMC7+ lymphocyte", "d": []}, {"i": "SNOMEDCT:117507002", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5556488", "l": "Zamtocabtagene Autoleucel", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157922", "l": "Cells | Left anterior chamber | NEI eyeGENE slit lamp biomicroscopy", "d": []}]}
{"type": "biolink:Cell", "ic": "90.82444074280258", "identifiers": [{"i": "CL:0000407", "l": "scolopidial ligament cell", "d": ["A cell that anchors the cell body of a scolopidial neuron to the integument."]}]}
{"type": "biolink:Cell", "ic": "43.016337286963591", "identifiers": [{"i": "CL:0000221", "l": "ectodermal cell", "d": ["A cell of the outer of the three germ layers of the embryo."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5690231", "l": "Neutrophils | Amniotic fluid | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1301171", "l": "Eccentrocyte (cell)", "d": []}, {"i": "SNOMEDCT:397051007", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1182615", "l": "General ecto-epithelial cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1180382", "l": "Regular cardiac myocyte", "d": []}]}
{"type": "biolink:Cell", "ic": "78.435418415656045", "identifiers": [{"i": "UMLS:C0023005", "l": "Langerhans cell", "d": []}, {"i": "NCIT:C12584", "l": "Langerhans Cell", "d": ["Dendritic clear cells in the epidermis, containing distinctive granules that appear rod- or racket-shaped in section, but lacking tonofilaments, melanosomes, and desmosomes; they carry surface receptors for immunoglobulin (Fc) and complement (C3), and are believed to be antigen fixing and processing cells of monocytic origin; active participants in cutaneous delayed hypersensitivity."]}, {"i": "MESH:D007801", "l": "Langerhans Cells", "d": []}, {"i": "SNOMEDCT:76322003", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2332975", "l": "Folliculostellate cell of pars distalis of adenohypophysis", "d": []}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "UMLS:C1512553", "l": "Hypergranular Promyelocyte", "d": []}, {"i": "NCIT:C37073", "l": "Hypergranular Promyelocyte", "d": []}]}
{"type": "biolink:Cell", "ic": "73.239986017158159", "identifiers": [{"i": "CL:0000782", "l": "myeloid dendritic cell", "d": ["A dendritic cell of the myeloid lineage."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5171527", "l": "Lupus erythematosus cells | Blood | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:4033042", "l": "metallothionein-positive alveolar macrophage", "d": ["An alveolar macrophage that expresses metallothionein."]}]}
{"type": "biolink:Cell", "ic": "49.664975988901155", "identifiers": [{"i": "UMLS:C1512104", "l": "Dysplastic Glandular Cell", "d": []}, {"i": "NCIT:C36794", "l": "Dysplastic Glandular Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C0018873", "l": "HeLa Cells", "d": []}, {"i": "NCIT:C20226", "l": "HeLa", "d": ["HeLa cells were developed from cervix adenocarcinoma of a 31-year-old Black female. The cells are positive for keratin by immunoperoxidase staining. HeLa cells have been reported to contain human papilloma virus 18 (HPV-18) sequences.  P53 expression was reported to be low, and normal levels of pRB (retinoblastoma suppressor) were found. Four typical HeLa marker chromosomes have been reported.  M1 is a rearranged long arm and centromere of chromosome 1 and the long arm of chromosome 3. M2 is a combination of short arm of chromosome 3 and long arm of chromosome 5.  M3 is an isochromosome of the short arm of chromosome 5. M4 consists of the long arm of chromosome 11 and an arm of chromosome 19. HeLa Marker Chromosomes: One copy of Ml, one copy of M2, four-five copies of M3, and two copies of M4 as revealed by G-banding patterns."]}, {"i": "MESH:D006367", "l": "HeLa Cells", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0009009", "l": "paneth cell of colon", "d": ["A paneth cell that is located in the epithelium of the colon."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0242697", "l": "Muscle Fibers", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0949376", "l": "Perineuronal Oligodendroglia", "d": []}]}
{"type": "biolink:Cell", "ic": "84.75972595860604", "identifiers": [{"i": "UMLS:C1709210", "l": "Neoplastic Vacuolated Stromal Cell", "d": []}, {"i": "NCIT:C54090", "l": "Neoplastic Vacuolated Stromal Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "58.671314681979048", "identifiers": [{"i": "CL:0008007", "l": "visceral muscle cell", "d": ["A muscle cell that is part of some visceral muscle."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:2000065", "l": "ovarian microvascular endothelial cell", "d": ["Any microvascular endothelial cell that is part of a female urethra."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1179606", "l": "Anterior lens cell", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0001058", "l": "plasmacytoid dendritic cell, human", "d": ["A plasmacytoid dendritic cell with the phenotype HLA-DRA-positive, CD123-positive, and CD11c-negative."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0376448", "l": "Jurkat Cells", "d": []}, {"i": "MESH:D019169", "l": "Jurkat Cells", "d": []}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "CL:1000435", "l": "epithelial cell of lacrimal duct", "d": ["An epithelial cell that is part of the lacrimal duct."]}]}
{"type": "biolink:Cell", "ic": "62.292266097803903", "identifiers": [{"i": "CL:0000785", "l": "mature B cell", "d": ["A B cell that is mature, having left the bone marrow. Initially, these cells are IgM-positive and IgD-positive, and they can be activated by antigen."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1440342", "l": "Cells.CD64", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5172360", "l": "Megakaryocytes/100 leukocytes | Blood | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:1000546", "l": "kidney medulla collecting duct epithelial cell", "d": []}]}
{"type": "biolink:Cell", "ic": "79.849015605436421", "identifiers": [{"i": "CL:0000605", "l": "fungal asexual spore", "d": ["A spore formed following mitosis or mitoses."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5571780", "l": "Siderocytes.Type 2", "d": []}]}
{"type": "biolink:Cell", "ic": "82.076046914303362", "identifiers": [{"i": "UMLS:C1708911", "l": "Malignant Spindle-Shaped Fibroblast", "d": []}, {"i": "NCIT:C49021", "l": "Malignant Spindle-Shaped Fibroblast", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5163718", "l": "Erythrocytes | Fetus | Pleural fluid | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:4030013", "l": "kidney loop of Henle long descending thin limb outer medulla epithelial cell", "d": ["Epithelial cell of the descending thin limb of the long loop (juxtamedullary) nephron that spans the outer medulla (inner stripe). It is known in some mammalian species that the long descending limb of the loop of Henle in the outer medulla selectively expresses the secreted activin-antagonist protein follistatin (Fst), the GPI-linked adhesion protein Cdh13, and the protein kinase Stk32a."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1184144", "l": "Luminal cell of alveolus of lactiferous gland", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5761866", "l": "ET 1402L1-CART", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1180392", "l": "Brush cell", "d": []}, {"i": "NCIT:C32236", "l": "Brush Cell", "d": ["A cell characterized by the presence of a tuft of blunt, squat microvilli (120-140/cell) on the cell surface. The microvilli contain filaments that stretch into the underlying cytoplasm. It has a distinctive pear shape with a wide base and a narrow microvillus apex. This cell is distinct from the unipolar brush cell found in the cerebellar cortex."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1440282", "l": "Cells.CD3+CD4+CD45RO+CD45RA+", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002572", "l": "vertebral mesenchymal stem cell", "d": ["A mesenchymal stem cell of the vertebrae."]}]}
{"type": "biolink:Cell", "ic": "64.608741564042447", "identifiers": [{"i": "UMLS:C1518222", "l": "Malignant Neuroendocrine Small Cell", "d": []}, {"i": "NCIT:C36820", "l": "Malignant Neuroendocrine Small Cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157326", "l": "CD16+CD56+ cells | Blood | Cell markers", "d": []}]}
{"type": "biolink:Cell", "ic": "80.511444690059548", "identifiers": [{"i": "CL:0002605", "l": "astrocyte of the cerebral cortex", "d": ["An astrocyte of the cerebral cortex."]}]}
{"type": "biolink:Cell", "ic": "92.728541327098611", "identifiers": [{"i": "CL:4023162", "l": "bushy cell", "d": ["A neuron found in the anterior part of the ventral cochlear nucleus that has the appearance of bushes, having short dendrites. Bushy cells give outputs to different parts of the superior olivary complex."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4696657", "l": "Cells.CD3+CD4+CD28+HLA DR+", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C0003273", "l": "Antibody-Producing Cells", "d": []}, {"i": "NCIT:C12611", "l": "Antibody-Producing Cell", "d": ["A type of B lymphocyte that reacts with antigens to produce immune proteins called antibodies."]}, {"i": "MESH:D000921", "l": "Antibody-Producing Cells", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1267980", "l": "Lymphocyte positive for CD93 antigen", "d": []}, {"i": "SNOMEDCT:117420002", "d": []}]}
{"type": "biolink:Cell", "ic": "78.695011174409487", "identifiers": [{"i": "UMLS:C4317010", "l": "Reactive Lymphocyte", "d": []}, {"i": "NCIT:C12847", "l": "Reactive Lymphocyte", "d": ["A type of white blood cell that enlarges in response to antigenic stimulation."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0011019", "l": "mesothelial cell of epicardium", "d": ["A mesothelial cell that is part of the epicardium."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4253033", "l": "Epithelial cell of intraprostatic part of ejaculatory duct", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0546506", "l": "P.B. reticulum cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1441122", "l": "Purkinje cell cytoplasmic type Tr", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1267907", "l": "Lymphocyte positive for CD33 antigen", "d": []}, {"i": "SNOMEDCT:117578008", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C4086009", "l": "Autologous T-lymphocytes-expressing NY-ESO-1-C259-specific Enhanced T-cell Receptors", "d": []}, {"i": "NCIT:C124655", "l": "Autologous T-lymphocytes-expressing NY-ESO-1-C259-specific Enhanced T-cell Receptors", "d": ["Human autologous lymphocytes transduced with a retroviral vector encoding a T-cell receptor (TCR) specific for the cancer/testis antigen NY-ESO-1, with potential antineoplastic activity. Upon isolation, transduction, expansion ex vivo, and reintroduction into the patient, the autologous T-lymphocytes expressing NY-ESO-1-C259-specific enhanced T-cell receptors bind to NY-ESO-1-overexpressing tumor cells. This may result in the specific cytotoxic T-lymphocyte (CTL) killing of NY-ESO-1-positive cancer cells. NY-ESO-1, a tumor-associated antigen (TAA), is found in normal testis and on the surface of various tumor cell types; the TCR is specific for SLLMWITQC, an NY-ESO-1-derived peptide, in a complex with human leukocyte antigen (HLA) A2 peptide."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1267805", "l": "HLE+ lymphocyte", "d": []}, {"i": "SNOMEDCT:117509004", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C3178739", "l": "Effector B Cells", "d": []}]}
{"type": "biolink:Cell", "ic": "84.75972595860604", "identifiers": [{"i": "UMLS:C1516949", "l": "Epithelioid Melanocyte", "d": []}, {"i": "NCIT:C36870", "l": "Epithelioid Melanocyte", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002656", "l": "glandular cell of endometrium", "d": ["A glandular epithelial cell of the endometrium."]}]}
{"type": "biolink:Cell", "ic": "90.82444074280258", "identifiers": [{"i": "UMLS:C1517810", "l": "Leukemic Natural Killer Cell", "d": []}, {"i": "NCIT:C41070", "l": "Leukemic Natural Killer Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "75.42073205405498", "identifiers": [{"i": "CL:1000428", "l": "stem cell of epidermis", "d": ["A somatic stem cell that is part of the epidermis."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1513032", "l": "Mature Thymocyte", "d": []}, {"i": "NCIT:C33062", "l": "Mature Thymocyte", "d": ["A cell derived in the thymus from a T cell progenitor and then differentiates into a T-Lymphocyte."]}]}
{"type": "biolink:Cell", "ic": "46.074997994768367", "identifiers": [{"i": "CL:0000183", "l": "contractile cell", "d": ["A cell whose primary function is to shorten."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157347", "l": "CD19 cells | Cerebral spinal fluid | Cell markers", "d": []}]}
{"type": "biolink:Cell", "ic": "90.82444074280258", "identifiers": [{"i": "UMLS:C1708891", "l": "Malignant Neuroectodermal Large Cell", "d": []}, {"i": "NCIT:C54043", "l": "Malignant Neuroectodermal Large Cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5216225", "l": "Leukocytes other|NCnc|Pt|CSF", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002604", "l": "hippocampal astrocyte", "d": ["An astrocyte that is part of the hippocampus."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C4733678", "l": "Autologous Anti-mesothelin CAR-CD3zeta-4-1-BB-expressing T-cells", "d": []}, {"i": "NCIT:C155909", "l": "Autologous Anti-mesothelin CAR-CD3zeta-4-1-BB-expressing T-cells", "d": ["A preparation of autologous T-lymphocytes transduced with a lentiviral vector expressing a chimeric antigen receptor (CAR) consisting of an anti-mesothelin M5 single chain variable fragment (scFv) fused to the costimulatory domains of 4-1BB (CD137) and the zeta chain of the TCR/CD3 complex (TCRzeta; CD247; CD3zeta), with potential immunomodulating and antineoplastic activities. After isolation, transduction, expansion in culture and reintroduction into the patient, the autologous anti-mesothelin CAR-CD3zeta-4-1BB-expressing T-cells specifically target and induce selective toxicity in mesothelin-expressing tumor cells. Mesothelin, a cell surface glycoprotein involved in cell adhesion, is overexpressed in a variety of cancer cell types."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1257743", "l": "3T3-L1 Cells", "d": []}, {"i": "MESH:D041721", "l": "3T3-L1 Cells", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1956421", "l": "Neoplastic Stem Cells", "d": []}, {"i": "MESH:D014411", "l": "Neoplastic Stem Cells", "d": []}]}
{"type": "biolink:Cell", "ic": "76.281523396999802", "identifiers": [{"i": "CL:0000909", "l": "CD8-positive, alpha-beta memory T cell", "d": ["A CD8-positive, alpha-beta T cell that has differentiated into a memory T cell."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1267802", "l": "CYIG+ lymphocyte", "d": []}, {"i": "SNOMEDCT:117506006", "d": []}]}
{"type": "biolink:Cell", "ic": "90.82444074280258", "identifiers": [{"i": "CL:0000614", "l": "basophilic myelocyte", "d": ["A basophil precursor in the granulocytic series, being a cell intermediate in development between a promyelocyte and a metamyelocyte; in this stage, production of primary granules is complete and basophil-specific granules has started. No nucleolus is present. Markers are being integrin alpha-M-positive, fucosyltransferase FUT4-positive, CD33-positive, CD24-positive, aminopeptidase N-positive."]}]}
{"type": "biolink:Cell", "ic": "84.128890093485552", "identifiers": [{"i": "CL:0001006", "l": "dermal dendritic cell", "d": ["Dermal dendritic cell is a conventional dendritic cell that is CD11b-positive, CD205-positive and CD8 alpha-negative."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5171870", "l": "Macrophages | Synovial fluid | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "ic": "79.849015605436421", "identifiers": [{"i": "UMLS:C1515962", "l": "Anaplastic Astrocyte", "d": []}, {"i": "NCIT:C37136", "l": "Anaplastic Astrocyte", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0009002", "l": "inflammatory cell", "d": ["Any cell participating in the inflammatory response to a foreign substance, e.g. neutrophil, macrophage."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C2985406", "l": "DU 145", "d": []}, {"i": "NCIT:C93036", "l": "DU 145", "d": ["A carcinoma cell line established from a brain metastasis from a 69 year old male patient with prostate carcinoma.  The carcinoma cells do not express PSA and are not sensitive to hormones."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4267710", "l": "100 cells.CD19+CD20+", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0000933", "l": "type II NK T cell secreting interleukin-4", "d": ["A type II NK T cell that has been recently activated, secretes interleukin-4, and has the phenotype CD69-positive and downregulated NK markers."]}]}
{"type": "biolink:Cell", "ic": "74.953330836288131", "identifiers": [{"i": "CL:0000800", "l": "mature gamma-delta T cell", "d": ["A gamma-delta T cell that has a mature phenotype. These cells can be found in tissues and circulation where they express unique TCR repertoire depending on their location."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0011029", "l": "cnidocyte", "d": ["An explosive cell containing one giant secretory organelle called a cnidocyst (also known as a cnida (plural cnidae) or nematocyst) that contains a toxin responsible for the stings delivered by a cnidarian to other organisms. Cnidae are used to capture prey and as a defense against predators. The presence of cnidocytes defines the phylum Cnidaria (corals, sea anemones, hydrae, jellyfish, etc.)."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5667075", "l": "Autologous Anti-CD7 CAR T Cells PA3-17", "d": []}, {"i": "NCIT:C186666", "l": "Autologous Anti-CD7 CAR T Cells PA3-17", "d": ["A preparation of autologous T-lymphocytes that have been genetically engineered to express a chimeric antigen receptor (CAR) directed against the tumor-associated antigen (TAA) CD7, with potential immunostimulating and antineoplastic activities. Upon intravenous administration, the autologous anti-CD7 CAR T-cells PA3-17 specifically recognize and bind to CD7-expressing tumor cells, resulting in specific T-cell-mediated tumor cell lysis. CD7 is a transmembrane glycoprotein expressed by T-cells and natural killer (NK) cells and their precursors. It is expressed in the majority of lymphoblastic T-cell leukemias and lymphomas and in a subset of peripheral T-cell lymphomas."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5382939", "l": "Interferon-gamma producing HLA-A1 Cytomegalovirus specific CD8 cells | Blood | Cell markers", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C3896657", "l": "Anti-CD3 OKT3/Humanized Anti-GD2 3F8 Bispecific Antibody-activated T Lymphocytes", "d": []}, {"i": "NCIT:C116330", "l": "Anti-CD3 OKT3/Humanized Anti-GD2 3F8 Bispecific Antibody-activated T Lymphocytes", "d": ["Autologous activated T cells that have been coated with bispecific antibodies (BiAb) comprised of anti-CD3 murine monoclonal antibody OKT3 heteroconjugated to anti-GD2 humanized monoclonal antibody 3F8 (hu3F8), with potential antineoplastic and immunomodulating activities. In vitro, T cells are exposed to OKT3, which binds to the T cell receptor-CD3 complex on the T cell surface, crosslinks the CD3 receptors and leads to T cell activation. In turn, the hu3F8 monoclonal antibody is heteroconjugated to OKT3. Upon administration, anti-CD3 x anti-GD2 bispecific antibody-armed activated T cells attach to GD2-expressing tumor cells, thereby selectively cross-linking T cells and tumor cells. This results in selective cytotoxicity towards the GD2-expressing tumor cells. In addition, cytokine and chemokine secretion by the T cells further activates the immune system, which leads to the recruitment and activation of cytotoxic T lymphocytes (CTLs), and additional CTL-mediated tumor-specific cell lysis. GD2, a disialoganglioside and tumor-associated antigen, is overexpressed in a variety of tumor cell types. CD3 is part of the functional T cell receptor (TCR) complex, which is necessary for antigen recognition by T cells, and is required for signal transduction."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5163549", "l": "Epithelial cells.non-squamous | Urine | Urinalysis", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0553257", "l": "Epithelial cell of renal tubule", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4722695", "l": "ACTolog IMA101", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1507172", "l": "Cells.CD3+TCR gamma delta+", "d": []}]}
{"type": "biolink:Cell", "ic": "68.095679833930788", "identifiers": [{"i": "CL:0002489", "l": "double negative thymocyte", "d": ["A thymocyte that lacks expression of CD4 and CD8."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157665", "l": "CD8 cells | XXX | Cell markers", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157622", "l": "CD57 cells | Blood | Cell markers", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4322814", "l": "CD45RB+ T lymphocyte", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5177618", "l": "Platelets | Body fluid | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5571673", "l": "Nucleated cells|NCnc|Pt|Synv fld", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0945921", "l": "Cells.CD2+CD26+", "d": []}]}
{"type": "biolink:Cell", "ic": "89.347505587204751", "identifiers": [{"i": "CL:0000293", "l": "structural cell", "d": ["A cell whose primary function is to provide structural support, to provide strength and physical integrity to the organism."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4241119", "l": "Mesencephalic neural crest cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157549", "l": "CD4+CD45RA+CD45RB+CD45RC+ cells | XXX | Cell markers", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2334745", "l": "Astroblast", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2326171", "l": "Pancreatic goblet cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5157552", "l": "CD4+CD45RO+ cells | Bone marrow | Cell markers", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:4023163", "l": "spherical bushy cell", "d": ["A bushy cell that receives only few large excitatory endbulb synapses from auditory nerves. Spherical bush cells give excitatory input to the lateral and medial parts of the superior olive."]}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "UMLS:C1708892", "l": "Malignant Neuroectodermal Round Cell", "d": []}, {"i": "NCIT:C54042", "l": "Malignant Neuroectodermal Round Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5205117", "l": "Cord Blood-derived CMV/AdV/EBV/BKV-specific Cytotoxic T-lymphocytes", "d": []}, {"i": "NCIT:C160294", "l": "Cord Blood-derived CMV/AdV/EBV/BKV-specific Cytotoxic T-lymphocytes", "d": ["A population of allogeneic expanded cord blood (CB)-derived cytotoxic T-lymphocytes (CTLs) that are specifically reactive to cytomegalovirus (CMV), Epstein-Barr virus (EBV), adenovirus (AdV), and human polyomavirus type I (BKV), with potential antiviral activity. Infusion of the CB-derived CMV/AdV /EBV/BKV-specific CTLs into CB hematopoietic stem cell transplant (HSCT) recipients may provide virus-specific cellular immunity, thereby preventing the infection or reactivation of certain viral-associated diseases."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4240446", "l": "Vascular smooth muscle cell of thoracic aorta", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0487470", "l": "Round Cells", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1440338", "l": "CD62E Cells", "d": []}]}
{"type": "biolink:Cell", "ic": "84.75972595860604", "identifiers": [{"i": "UMLS:C1511569", "l": "CyThera ES Cell Line", "d": []}, {"i": "NCIT:C20246", "l": "CyThera ES Cell Line", "d": []}]}
{"type": "biolink:Cell", "ic": "87.120474278337809", "identifiers": [{"i": "CL:0000960", "l": "T3 B cell", "d": ["A transitional stage B cell that expresses surface IgM and IgD, and CD62L. This cell type appears to be an anergic B cell that does not proliferate upon BCR signaling, is found in the spleen and lymph nodes, and has the phenotype surface IgM-positive, surface IgD-positive, CD21-positive, CD23-positive, CD62L-positive, and CD93-positive. This cell type has also been described as IgM-low, CD19-positive, B220-positive, AA4-positive, and CD23-positive (i.e. this cell-type is distinguished from T2 cells by surface expression of IgM)."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4267787", "l": "Cells.CD27-CD45RA-", "d": []}]}
{"type": "biolink:Cell", "ic": "78.695011174409487", "identifiers": [{"i": "CL:0000856", "l": "neuromast hair cell", "d": ["Neuromast hair cell is a hair cell that acts as a sensory receptor of the neuromast; it is morphologically polarized as a result of the relative position of the single kinocilium and the clusters of stereocilia on its apical surface."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0807107", "l": "Vacuolated neutrophil", "d": []}, {"i": "SNOMEDCT:726746002", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0000628", "l": "photosynthetic cell", "d": ["A cell that can perform photosynthesis, in which carbohydrates are synthesized from carbon dioxide and water, using light as the energy source."]}]}
{"type": "biolink:Cell", "ic": "60.545495054889464", "identifiers": [{"i": "UMLS:C1514022", "l": "Neoplastic Melanocyte", "d": []}, {"i": "NCIT:C36862", "l": "Neoplastic Melanocyte", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4322730", "l": "CD5+CD25+ B lymphocyte", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5419437", "l": "Cord Blood Derived CAR T-Cells", "d": []}, {"i": "NCIT:C172058", "l": "Cord Blood Derived CAR T-Cells", "d": ["A preparation of umbilical cord blood (CB)-derived T-lymphocytes that are genetically engineered to express a chimeric antigen receptor (CAR) that targets an as of yet unidentified tumor-associated antigen (TAA), with potential immunomodulatory and antineoplastic activities. Upon administration of the cord blood derived CAR T-cells, the T-cells target, bind to and induce selective cytotoxicity in tumor cells expressing the TAA."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5417842", "l": "Autologous Bispecific CD19/CD22-targeted CAR-T Cells GC022", "d": []}, {"i": "NCIT:C171093", "l": "Autologous Bispecific CD19/CD22-targeted CAR-T Cells GC022", "d": ["A preparation of autologous human T-lymphocytes engineered to express chimeric T-cell receptors (chimeric antigen receptors or CARs) targeting the tumor-associated antigens (TAAs) CD19 and CD22 and fused to as of yet not fully elucidated co-stimulatory domains, with potential immunostimulating and antineoplastic activities. Upon administration, the autologous bispecific CD19/CD22-targeted CAR-T cells GC022 bind to CD19 and CD22 on the surface of, and induce selective toxicity against, tumor cells expressing CD19 and CD22. CD19 and CD22, both transmembrane phosphoglycoproteins expressed on the surface of cells in the B lineage, are overexpressed on malignant B-cells."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5171584", "l": "Lymphoblasts | Blood | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C0085236", "l": "Macrophages, Alveolar", "d": []}, {"i": "NCIT:C12565", "l": "Alveolar Macrophage", "d": ["Phagocytic macrophages on the surface of the pulmonary alveoli.  They ingest foreign substances inhaled into the alveoli."]}, {"i": "MESH:D016676", "l": "Macrophages, Alveolar", "d": []}, {"i": "SNOMEDCT:33956004", "d": []}]}
{"type": "biolink:Cell", "ic": "75.923665061460838", "identifiers": [{"i": "UMLS:C1514273", "l": "Postgerminal Center Marginal Zone B-Lymphocyte", "d": []}, {"i": "NCIT:C38334", "l": "Postgerminal Center Marginal Zone B-Lymphocyte", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1183900", "l": "Basal cell of prostatic duct", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1278781", "l": "Entire thyroid parafollicular cell", "d": []}, {"i": "SNOMEDCT:176770005", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1440380", "l": "Cells.cyclin D1", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5690883", "l": "Tumor-Infiltrating B Cells", "d": []}]}
{"type": "biolink:Cell", "ic": "88.140761698499901", "identifiers": [{"i": "CL:0007011", "l": "enteric neuron", "d": ["Neuron that is part of the enteric nervous system."]}]}
{"type": "biolink:Cell", "ic": "56.583435665559108", "identifiers": [{"i": "CL:0000199", "l": "mechanoreceptor cell", "d": ["A cell specialized to transduce mechanical stimuli and relay that information centrally in the nervous system."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C4763825", "l": "Autologous Anti-PSCA-CAR-4-1BB/TCRzeta-CD19t-expressing T-lymphocytes", "d": []}, {"i": "NCIT:C157746", "l": "Autologous Anti-PSCA-CAR-4-1BB/TCRzeta-CD19t-expressing T-lymphocytes", "d": ["A preparation of autologous T-lymphocytes that have been immunomagnetically depleted of CD14+ myeloid cells and CD25+ regulatory T-cells (Tregs), activated with anti-CD3 and anti-CD28 beads, and transduced with a self-inactivating (SIN) lentiviral vector (LV) encoding a chimeric antigen receptor (CAR) containing a prostate stem cell antigen (PSCA)-specific, humanized and affinity matured A11 single chain variable fragment (scFv), a human immunoglobulin G4 (IgG4) Fc spacer lacking the CH2 domain, a human CD4 transmembrane domain, a costimulatory human 4-1BB (CD137) cytoplasmic signaling domain linked to the zeta chain of the human T-cell receptor (TCR)/CD3 complex (CD3zeta), and a truncated human CD19 sequence (CD19t), with potential immunostimulating and antineoplastic activities. Upon intravenous infusion, the autologous anti-PSCA-CAR-4-1BB/TCRzeta-CD19t-expressing T-lymphocytes recognize and induce selective toxicity in PSCA-expressing tumor cells. PSCA, a glycosyl-phosphatidylinositol (GPI)-linked cell surface antigen, is uniquely and highly expressed in certain cancers including bladder, pancreatic, and prostate cancers. Co-expression of CD19t provides an inert, non-immunogenic surface marker that allows for measurement of genetically modified cells and tracking of T-cells following adoptive transfer. The costimulatory signaling domains improve T-cell function, selectivity, expansion and survival."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1317395", "l": "Immature granulocyte", "d": []}, {"i": "NCIT:C13113", "l": "Immature Granulocyte", "d": ["A not-yet-mature white blood cell with staining granules in its cytoplasm. The staining granules may be neutrophilic, acidophilic, or basophilic in character. There are indications that an immature granulocyte count is a better measure of infection and sepsis than a total white blood cell count and comparable to absolute neutrophil count."]}, {"i": "SNOMEDCT:726594001", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5175154", "l": "Nucleated cells | Synovial fluid | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1440243", "l": "CD117 Cells", "d": []}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "UMLS:C1516515", "l": "Chromophobe cell", "d": []}, {"i": "NCIT:C32313", "l": "Chromophobe Cell", "d": ["A small, faintly staining cell with scanty cytoplasm and rounded or polygonal contours. It is found in clusters in the anterior lobe of the pituitary gland."]}]}
{"type": "biolink:Cell", "ic": "89.347505587204751", "identifiers": [{"i": "CL:0017000", "l": "pulmonary ionocyte", "d": ["An ionocyte that is part of the lung epithelium. The cells from this type are major sources of the CFTR protein in human and mice."]}]}
{"type": "biolink:Cell", "ic": "92.728541327098611", "identifiers": [{"i": "UMLS:C0227651", "l": "Mesangial Cells, Kidney", "d": []}, {"i": "NCIT:C13159", "l": "Mesangial Cell", "d": ["Cell found within the glomerular lobules of mammalian kidney. Mesangial cells serve as structural supports, may regulate blood flow, are phagocytic and may act as accessory cells, presenting antigen in immune responses."]}, {"i": "MESH:D050527", "l": "Mesangial Cells", "d": []}, {"i": "SNOMEDCT:24259000", "d": []}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "CL:1000441", "l": "epithelial cell of viscerocranial mucosa", "d": ["An epithelial cell that is part of the viscerocranial mucosa."]}]}
{"type": "biolink:Cell", "ic": "80.869303025598512", "identifiers": [{"i": "CL:1000448", "l": "epithelial cell of sweat gland", "d": ["An epithelial cell that is part of the sweat gland."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C0034143", "l": "Purkinje Cells", "d": []}, {"i": "NCIT:C12651", "l": "Purkinje Cell", "d": ["A large neuron that transmits signals from the cerebellar cortex and play a major role in controlling motor movement."]}, {"i": "MESH:D011689", "l": "Purkinje Cells", "d": []}, {"i": "SNOMEDCT:83626009", "d": []}]}
{"type": "biolink:Cell", "ic": "85.457082654197222", "identifiers": [{"i": "CL:0000921", "l": "type I NK T cell", "d": ["An alpha-beta T cell expressing NK cell markers that is CD1d restricted and expresses specific V-alpha chains. NK T cells of this type recognize the glycolipid alpha-galactosylceramide in the context of CD1d."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5154298", "l": "Band form neutrophils | Body fluid | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2736935", "l": "Cells.CD56+CD138+", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0003009", "l": "G6 retinal ganglion cell", "d": ["A mono-stratified retinal ganglion cell that has a medium dendritic field and a sparse dendritic arbor with post sympatic terminals in sublaminar layer S4 and S5."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0001017", "l": "mature CD1a-positive Langerhans cell", "d": ["Mature CD1a-positive Langerhans cell is a CD1a-positive Langerhans cell that is CD80-high, CD86-high, MHCII-high and is CD83-positive."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0000917", "l": "Tc1 cell", "d": ["A CD8-positive, alpha-beta positive T cell that has the phenotype T-bet-positive, eomesodermin-positive, CXCR3-positive, CCR6-negative, and is capable of producing interferon-gamma."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1115672", "l": "Lymphocytes.kappa", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1512310", "l": "HL60", "d": []}, {"i": "NCIT:C19433", "l": "HL60", "d": ["HL-60 is a promyelocytic cell line derived by S.J. Collins, et al. Peripheral blood leukocytes were obtained by leukopheresis from a 36-year-old Caucasian female with acute promyelocytic leukemia. The cells resemble promyelocytes. In vitro the cells can be induced to differentiate terminally into granulocyte-like cells or monocyte/macrophage-like cells, depending on the inducing agent. This cell line has been used as a model for human myeloid cell differentiation."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1282866", "l": "Entire blastomere", "d": []}, {"i": "SNOMEDCT:343113005", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0000869", "l": "tonsillar macrophage", "d": ["A gut-associated lymphoid tissue macrophage found in tonsils."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0521182", "l": "Opalski cell", "d": []}, {"i": "SNOMEDCT:83687003", "d": []}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "UMLS:C1514437", "l": "Primitive Mesenchymal Round Cell", "d": []}, {"i": "NCIT:C36910", "l": "Primitive Mesenchymal Round Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5419316", "l": "Simoladagene Autotemcel", "d": []}, {"i": "NCIT:C171810", "l": "Simoladagene Autotemcel", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5167928", "l": "HLA-DR+ cells | Blood | Cell markers", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0683198", "l": "spermatosome", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0001079", "l": "NKp44-positive group 3 innate lymphoid cell, human", "d": ["A group 3 innate lymphoid cell in the human with the phenotype IL-7Ralpha-positive, and NKp44-positive."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1522237", "l": "Thyroid Gland - Parafollicular Cell (MMHCC)", "d": []}, {"i": "NCIT:C22651", "l": "Mouse Thyroid Gland Parafollicular Cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1267797", "l": "Lymphocyte positive for CDA antigen", "d": []}, {"i": "SNOMEDCT:117501001", "d": []}]}
{"type": "biolink:Cell", "ic": "87.120474278337809", "identifiers": [{"i": "UMLS:C1710401", "l": "Thymic Medullary Epithelial Cell", "d": []}, {"i": "NCIT:C45702", "l": "Thymic Medullary Epithelial Cell", "d": ["An epithelial cell located in the inner portion of the thymus where the T lymphocytes become mature and are released into the circulation."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5705653", "l": "Allogeneic human retinal pigment epithelial cells on gelatin microcarriers", "d": []}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "CL:0002227", "l": "nucleated secondary lens fiber", "d": ["A secondary fiber cell that contains a nucleus."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4697026", "l": "Cells.CD27+IgD-IgM+", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1440412", "l": "Cells.t(5;12)(q33.1;p13)(PDGFRB,ETV6)", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5447474", "l": "Lovotibeglogene Autotemcel", "d": []}]}
{"type": "biolink:Cell", "ic": "83.552982069901191", "identifiers": [{"i": "UMLS:C1515965", "l": "Anaplastic Large B-Lymphocyte", "d": []}, {"i": "NCIT:C37015", "l": "Anaplastic Large B-Lymphocyte", "d": []}]}
{"type": "biolink:Cell", "ic": "61.059660402022018", "identifiers": [{"i": "CL:0008031", "l": "cortical interneuron", "d": ["An interneuron that has its soma located in the cerebral cortex."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:1000369", "l": "transitional myocyte of septal division of left branch of atrioventricular bundle", "d": ["A transitional myocyte that is part of the septal division of left branch of atrioventricular bundle."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C4289937", "l": "Baltaleucel-T", "d": []}, {"i": "NCIT:C129374", "l": "Baltaleucel-T", "d": ["A preparation of autologous Epstein-Barr virus (EBV)-specific cytotoxic T-lymphocytes (CTLs), which have specific reactivity to the EBV antigens, latent membrane proteins (LMP) 1 (LMP1) and 2 (LMP2), EBV nuclear antigen (EBNA) and BamHI-A rightward frame-1 (BARF1), with potential immunomodulating and antineoplastic activities. Upon administration, baltaleucel-T targets and binds to EBV-expressing cancer cells specifically expressing the targeted antigens. This may kill LMP1/LMP2/EBNA/BARF1-expressing EBV-associated cancer cells. LMP1, LMP2, EBNA and BARF1 are tumor-associated antigens (TAAs) that are specifically associated with EBV infection, and play key roles in the proliferation of a variety of tumors."]}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "UMLS:C1879716", "l": "Apocrine Carcinoma Cell with Eosinophilic Granular Cytoplasm", "d": []}, {"i": "NCIT:C62206", "l": "Apocrine Carcinoma Cell with Eosinophilic Granular Cytoplasm", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002628", "l": "immature microglial cell", "d": ["An immature microglial cell with a ramified morphology."]}]}
{"type": "biolink:Cell", "ic": "81.247621244257502", "identifiers": [{"i": "UMLS:C1881560", "l": "Malignant Hyperchromatic Small Epithelial Cell", "d": []}, {"i": "NCIT:C61588", "l": "Malignant Hyperchromatic Small Epithelial Cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5171712", "l": "Lymphocytes.vacuolated | Blood | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "ic": "88.140761698499901", "identifiers": [{"i": "CL:0011008", "l": "embryonic hemocyte", "d": ["A hemocyte derived from the embryonic head mesoderm, which enters the hemolymph as a circulating cell."]}]}
{"type": "biolink:Cell", "ic": "62.095329578860287", "identifiers": [{"i": "CL:0000333", "l": "migratory neural crest cell", "d": ["A cell derived from the specialized ectoderm flanking each side of the embryonic neural plate, which after the closure of the neural tube, forms masses of cells that migrate out from the dorsal aspect of the neural tube to spread throughout the body."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5669551", "l": "Donor-derived Haploidentical IL-21-Expanded Natural Killer Cells", "d": []}, {"i": "NCIT:C184812", "l": "Donor-derived Haploidentical IL-21-Expanded Natural Killer Cells", "d": ["A population of ex-vivo human interleukin-21 (IL-21) expanded donor-derived human leukocyte antigen (HLA) haploidentical natural killer (haploNK) cells, with potential immunomodulating and antineoplastic activities. Upon administration in patients undergoing HLA-haploidentical hematopoietic cell transplantation, the donor-derived haploidentical IL-21-expanded NK cells target, lyse and destroy tumor cells. IL-21 promotes sustained ex vivo proliferation of human NK cells and enhances its cytotoxic activity."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4518174", "l": "Population of all hyperchromic erythrocytes in portion of fluid", "d": []}, {"i": "SNOMEDCT:725442005", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0002637", "l": "keratinized epithelial cell of the anal canal", "d": ["An epithelial cell of the anal canal that is keratinized. This cell type is found towards the lower, rectal end of the anal canal."]}]}
{"type": "biolink:Cell", "ic": "95.41222037140129", "identifiers": [{"i": "CL:0002540", "l": "mesenchymal stem cell of the bone marrow", "d": ["A mesenchymal stem cell that is part of the bone marrow."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:3000000", "l": "ciliated epithelial cell of esophagus", "d": ["A ciliated epithelial cell of the esophagus."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5427250", "l": "Macrophages | Prostatic fluid | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1440237", "l": "Cell positive for CD105 antigen", "d": []}, {"i": "SNOMEDCT:725330004", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4696655", "l": "Cells.CD3+CD8+CD28+HLA DR+", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2324839", "l": "Set of cholinergic cells of diagonal gyrus [Ch3]", "d": []}]}
{"type": "biolink:Cell", "ic": "80.869303025598512", "identifiers": [{"i": "UMLS:C1519602", "l": "Activated Skin-Homing T-Lymphocyte", "d": []}, {"i": "NCIT:C39686", "l": "Activated Skin-Homing T-Lymphocyte", "d": ["A white blood cell, differentiated in the thymus, activated by an antigen that causes the cell to preferentially migrate to the skin."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5171675", "l": "Lymphocytes Immunoblastic | Blood | Hematology and Cell counts", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4695998", "l": "Cells.CD3+CD8+CD27-CD45RO+CD62L-", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4505192", "l": "THP-1 Cells", "d": []}, {"i": "MESH:D000074084", "l": "THP-1 Cells", "d": []}]}
{"type": "biolink:Cell", "ic": "60.84203750265889", "identifiers": [{"i": "CL:0000234", "l": "phagocyte", "d": ["Any cell capable of ingesting particulate matter via phagocytosis."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5380996", "l": "Cells.CD8.HLA-A2 CMV specific.CMV antigen stimulated gamma interferon producing", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2951827", "l": "Endothelial cell of endocardium of ventricle", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4527227", "l": "Allogeneic CD19-specific Universal CAR19-expressing T-lymphocytes", "d": []}]}
{"type": "biolink:Cell", "ic": "88.140761698499901", "identifiers": [{"i": "UMLS:C1882051", "l": "Neoplastic Epithelial Small Oval Cell", "d": []}, {"i": "NCIT:C60998", "l": "Neoplastic Epithelial Small Oval Cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1183167", "l": "Set of aminergic cells", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0230520", "l": "Mitotic cell in metaphase", "d": []}, {"i": "SNOMEDCT:38980003", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C5556445", "l": "Autologous Anti-MART-1 F5 TCR Tumor Infiltrating Lymphocytes", "d": []}, {"i": "NCIT:C180529", "l": "Autologous Anti-MART-1 F5 TCR Tumor Infiltrating Lymphocytes", "d": ["A preparation of human tumor infiltrating lymphocytes (TILs) isolated from a melanoma patient and engineered to encode a T-cell receptor (TCR) specific for an epitope of MART-1 (F5 TCR), with potential immunomodulating and antineoplastic activities. Upon administration, the autologous anti-MART-1 F5 TCR TILs may recognize and halt the growth of MART-1-expressing melanoma cells."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4267788", "l": "Cells.CD27+IgD+", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1267937", "l": "Lymphocyte positive for CD49B antigen", "d": []}, {"i": "SNOMEDCT:117380001", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:1000335", "l": "enterocyte of epithelium of intestinal villus", "d": ["An enterocyte that is part of the epithelium of intestinal villus."]}]}
{"type": "biolink:Cell", "ic": "83.023198044254755", "identifiers": [{"i": "UMLS:C1514186", "l": "Pluripotent Bone Marrow Stem Cell", "d": []}, {"i": "NCIT:C33331", "l": "Pluripotent Bone Marrow Stem Cell", "d": ["A bone marrow stem cell able to differentiate into any given cell type."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1267918", "l": "Lymphocyte positive for CD41 antigen", "d": []}, {"i": "SNOMEDCT:117586008", "d": []}]}
{"type": "biolink:Cell", "ic": "74.37742281270377", "identifiers": [{"i": "CL:0002254", "l": "epithelial cell of small intestine", "d": ["An epithelial cell of the small intestine."]}]}
{"type": "biolink:Cell", "ic": "66.835772872909402", "identifiers": [{"i": "CL:0000077", "l": "mesothelial cell", "d": ["A flattened epithelial cell of mesenchymal origin that lines the serous cavity."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:0000315", "l": "tear secreting cell", "d": ["A cell secreting tears, the fluid secreted by the lacrimal glands. This fluid moistens the conjunctiva and cornea."]}]}
{"type": "biolink:Cell", "ic": "49.072607457159044", "identifiers": [{"i": "UMLS:C1513983", "l": "Neoplastic Hematopoietic and Lymphoid Cell", "d": []}, {"i": "NCIT:C37060", "l": "Neoplastic Hematopoietic and Lymphoid Cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5155146", "l": "Bladder cells | Urine sediment | Urinalysis", "d": []}]}
{"type": "biolink:Cell", "ic": "92.728541327098611", "identifiers": [{"i": "CL:0000711", "l": "cumulus cell", "d": ["Cumulus cell is a specialized granulosa cell that surrounds and nourishes the oocyte. This cell-type surrounds the fully-grown oocyte to form a cumulus-oocyte complex (abbr. COC). The terms cumulus oophorus cells, cumulus granulosa cells, cumulus oophorous granulosa cells, granulosa-cumulus cells are used to make a distinction between this cell and the other functionally different subpopulation of granulosa cells at the wall of the Graafian follicle."]}]}
{"type": "biolink:Cell", "ic": "84.128890093485552", "identifiers": [{"i": "CL:0000611", "l": "eosinophil progenitor cell", "d": []}]}
{"type": "biolink:Cell", "ic": "73.011730055819953", "identifiers": [{"i": "UMLS:C1709179", "l": "Neoplastic Histiocytic and Dendritic Cell", "d": []}, {"i": "NCIT:C43253", "l": "Neoplastic Histiocytic and Dendritic Cell", "d": []}]}
{"type": "biolink:Cell", "ic": "92.728541327098611", "identifiers": [{"i": "UMLS:C1518353", "l": "Malignant Non-Cutaneous Basaloid Cell", "d": []}, {"i": "NCIT:C36783", "l": "Malignant Non-Cutaneous Basaloid Cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C5187201", "l": "RBC^Patient", "d": []}]}
{"type": "biolink:Cell", "ic": "69.653168928076894", "identifiers": [{"i": "UMLS:C1514045", "l": "Neoplastic Neuroendocrine Polygonal Cell", "d": []}, {"i": "NCIT:C36933", "l": "Neoplastic Neuroendocrine Polygonal Cell", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C3871166", "l": "2000 erythrocytes", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C2826112", "l": "Autologous NY-ESO-1-Melanoma-Specific CD8+ T-lymphocytes", "d": []}, {"i": "NCIT:C82350", "l": "Autologous NY-ESO-1-Melanoma-Specific CD8+ T-lymphocytes", "d": ["A preparation of autologous CD8+ (cytotoxic) T-lymphocytes sensitized to cancer-testis antigen NY-ESO-1 antigen with potential immunostimulating and antineoplastic activities. Autologous CD8+ T-lymphocytes, isolated from a melanoma patient, are exposed to an NY-ESO-1 peptide ex vivo, expanded, and reintroduced into the patient; these tumor-reactive T-cells may stimulate a host immune response against tumor cells expressing the NY-ESO-1 antigen, resulting in tumor cell lysis. NY-ESO-1, an antigen found in normal testis, may be upregulated in various cancers, including bladder, breast, hepatocellular, melanoma, and prostate cancers."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0440740", "l": "Granulocyte-specific", "d": []}, {"i": "SNOMEDCT:256910006", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:4033046", "l": "ON midget ganglion cell", "d": ["A midget ganglion cell that depolarizes in response to increased light intensity in the center of its receptive field. The majority of input that this cell receives comes from invaginating midget bipolar cells."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2339291", "l": "Syncytial giant cell", "d": []}]}
{"type": "biolink:Cell", "ic": "90.82444074280258", "identifiers": [{"i": "CL:0001023", "l": "Kit-positive, CD34-positive common myeloid progenitor", "d": ["A common myeloid progenitor that is Kit-positive and CD34-positive, Il7ra-negative, and is SCA1-low and Fcgr2-low and Fcgr3-low."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C4304495", "l": "Population of all spherocytes in portion of fluid", "d": []}, {"i": "SNOMEDCT:719693004", "d": []}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1440341", "l": "Cells.CD63", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "CL:4023129", "l": "retinoblast", "d": ["A retinal cell that is immature or undifferentiated."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C0682520", "l": "canine cell line", "d": []}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C2347433", "l": "Adipose-Derived Regenerative Cells", "d": []}, {"i": "NCIT:C73997", "l": "Adipose-Derived Regenerative Cells", "d": ["A population of cells derived from adipose tissue with stem cell and wound repair activities. Adipose-derived regenerative cells (ADRC) consists of several cell types, such as adult stem cells, vascular endothelial cells, and vascular smooth muscle cells, among others. These cells contribute to wound repair through a variety of mechanisms by promoting blood vessel growth and blocking apoptosis. In addition, ADRC can differentiate into several tissue types, such as bone, cartilage, fat, skeletal muscle, smooth muscle and cardiac muscle."]}]}
{"type": "biolink:Cell", "ic": "100", "identifiers": [{"i": "UMLS:C1512132", "l": "ES03", "d": []}, {"i": "NCIT:C20251", "l": "ES03", "d": ["Provider: ES Cell International Pte Ltd., Melbourne, Australia. Information from provider and not independently verified by NIH: Cells are positive for cell markers Oct-4, SSEA-4, TRA-1-60, GCTM-2, and alkaline phosphatase activity; Cells are negative for cell marker SSEA-1; Give rise to teratomas containing derivatives of three germ layers in SCID mice; Differentiate in vitro into extraembryonic and somatic cell lineages; Neural progenitor cells may be isolated from differentiating ES cell cultures and induced to form mature neurons; Available for distribution. This cell line meets the criteria for the use of human embryonic stem cells by federally funded researchers."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C1183362", "l": "Type-6 epithelial cell of thymus", "d": []}]}
{"type": "biolink:Cell", "ic": "53.48197286233431", "identifiers": [{"i": "CL:0000737", "l": "striated muscle cell", "d": ["Muscle cell which has as its direct parts myofilaments organized into sarcomeres."]}]}
{"type": "biolink:Cell", "identifiers": [{"i": "UMLS:C2350247", "l": "Monocyte-Macrophage Progenitor Cells", "d": []}]}