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PAMP-triggered immunity PRRs bind pathogen-associated molecular pattern (PAMPs), structures conserved among microbial species."]}]} {"type": "biolink:Pathway", "identifiers": [{"i": "REACT:R-BTA-1799339", "l": "SRP-dependent cotranslational protein targeting to membrane (Bos taurus)", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0039354", "l": "De Novo Triacylglycerol Biosynthesis TG(a-25:0/i-15:0/20:0),Metabolic", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0061286", "l": "Cardiolipin Biosynthesis CL(i-14:0/a-15:0/i-13:0/a-25:0),Disease", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "REACT:R-XTR-212300", "l": "PRC2 methylates histones and DNA (Xenopus tropicalis)", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0031976", "l": "De Novo Triacylglycerol Biosynthesis TG(10:0/a-15:0/i-20:0),Metabolic", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0037830", "l": "De Novo Triacylglycerol Biosynthesis TG(8:0/i-22:0/i-18:0),Metabolic", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "REACT:R-CFA-112040", "l": "G-protein mediated events (Canis familiaris)", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0027944", "l": "Cardiolipin Biosynthesis CL(18:0/16:0/18:1(11Z)/18:1(11Z)),Metabolic", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "REACT:R-BTA-72165", "l": "mRNA Splicing - Minor Pathway (Bos taurus)", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "REACT:R-HSA-429914", "l": "Deadenylation-dependent mRNA decay (Homo sapiens)", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0059268", "l": "Cardiolipin Biosynthesis CL(i-13:0/i-19:0/a-21:0/i-24:0),Disease", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "REACT:R-SCE-76005", "l": "Response to elevated platelet cytosolic Ca2+ (Saccharomyces cerevisiae)", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0042895", "l": "De Novo Triacylglycerol Biosynthesis TG(i-24:0/a-17:0/21:0),Metabolic", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0034164", "l": "De Novo Triacylglycerol Biosynthesis TG(20:0/i-15:0/18:0),Metabolic", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "REACT:R-DME-429958", "l": "mRNA decay by 3' to 5' exoribonuclease (Drosophila melanogaster)", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "REACT:R-DDI-2142845", "l": "Hyaluronan metabolism (Dictyostelium discoideum)", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "REACT:R-CFA-5661231", "l": "Metallothioneins bind metals (Canis familiaris)", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "REACT:R-DME-1614517", "l": "Sulfide oxidation to sulfate (Drosophila melanogaster)", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0040217", "l": "De Novo Triacylglycerol Biosynthesis TG(i-20:0/a-13:0/14:0),Metabolic", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "REACT:R-GGA-9664873", "l": "Pexophagy (Gallus gallus)", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0000199", "l": "Maple Syrup Urine Disease,Disease", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "REACT:R-HSA-9013408", "l": "RHOG GTPase cycle (Homo sapiens)", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0041897", "l": "De Novo Triacylglycerol Biosynthesis TG(i-22:0/21:0/i-24:0),Metabolic", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0035957", "l": "De Novo Triacylglycerol Biosynthesis TG(21:0/i-22:0/15:0),Metabolic", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0026487", "l": "De Novo Triacylglycerol Biosynthesis TG(22:0/14:0/19:0),Metabolic", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0056369", "l": "Cardiolipin Biosynthesis CL(i-13:0/a-21:0/i-13:0/i-15:0),Disease", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0038053", "l": "De Novo Triacylglycerol Biosynthesis TG(a-21:0/17:0/a-15:0),Metabolic", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0051966", "l": "Cardiolipin Biosynthesis CL(i-12:0/i-14:0/i-20:0/a-25:0),Disease", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0031929", "l": "De Novo Triacylglycerol Biosynthesis TG(10:0/a-13:0/19:0),Metabolic", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0044797", "l": "Cardiolipin Biosynthesis CL(a-13:0/a-21:0/i-16:0/i-12:0),Disease", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "REACT:R-DME-390146", "l": "Hippo/Warts pathway (Drosophila melanogaster)", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0047833", "l": "Cardiolipin Biosynthesis CL(a-13:0/i-19:0/i-24:0/i-21:0),Disease", "d": []}]} {"type": "biolink:Pathway", 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PCNA-containing replication complex (Xenopus tropicalis)", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "REACT:R-DME-449147", "l": "Signaling by Interleukins (Drosophila melanogaster)", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0035356", "l": "De Novo Triacylglycerol Biosynthesis TG(21:0/14:0/i-15:0),Metabolic", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0043673", "l": "Cardiolipin Biosynthesis CL(a-13:0/a-13:0/a-13:0/i-17:0),Disease", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "REACT:R-DME-74751", "l": "Insulin receptor signalling cascade (Drosophila melanogaster)", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "REACT:R-CFA-187015", "l": "Activation of TRKA receptors (Canis familiaris)", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "REACT:R-CEL-381771", "l": "Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) (Caenorhabditis elegans)", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0050044", "l": "Cardiolipin Biosynthesis CL(i-12:0/a-15:0/i-21:0/i-12:0),Disease", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0060770", "l": "Cardiolipin Biosynthesis CL(i-13:0/i-24:0/i-20:0/i-18:0),Disease", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "REACT:R-PFA-556833", "l": "Metabolism of lipids (Plasmodium falciparum)", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0052328", "l": "Cardiolipin Biosynthesis CL(i-12:0/i-15:0/i-22:0/i-15:0),Disease", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "REACT:R-GGA-72662", "l": "Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S (Gallus gallus)", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "REACT:R-RNO-4090294", "l": "SUMOylation of intracellular receptors (Rattus norvegicus)", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0056477", "l": "Cardiolipin Biosynthesis CL(i-13:0/a-21:0/i-19:0/i-15:0),Disease", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0034126", "l": "De Novo Triacylglycerol Biosynthesis TG(20:0/i-13:0/i-22:0),Metabolic", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "REACT:R-RNO-1482922", "l": "Acyl chain remodelling of PI (Rattus norvegicus)", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0015895", "l": "Phosphatidylethanolamine Biosynthesis PE(24:1(15Z)/24:1(15Z)),Metabolic", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0060020", "l": "Cardiolipin Biosynthesis CL(i-13:0/i-21:0/i-15:0/i-24:0),Disease", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0063387", "l": "Cardiolipin Biosynthesis CL(i-14:0/i-17:0/i-14:0/i-21:0),Disease", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "REACT:R-BTA-2682334", "l": "EPH-Ephrin signaling (Bos taurus)", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0061440", "l": "Cardiolipin Biosynthesis CL(i-14:0/a-15:0/i-21:0/i-21:0),Disease", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0049854", "l": "Cardiolipin Biosynthesis CL(i-12:0/a-15:0/a-21:0/i-21:0),Disease", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0040796", "l": "De Novo Triacylglycerol Biosynthesis TG(i-21:0/14:0/12:0),Metabolic", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "REACT:R-CEL-450302", "l": "activated TAK1 mediates p38 MAPK activation (Caenorhabditis elegans)", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0038305", "l": "De Novo Triacylglycerol Biosynthesis TG(a-21:0/a-17:0/17:0),Metabolic", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0055444", "l": "Cardiolipin Biosynthesis CL(i-13:0/a-13:0/i-16:0/a-13:0),Disease", "d": []}]} {"type": "biolink:Pathway", 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"identifiers": [{"i": "REACT:R-DRE-110362", "l": "POLB-Dependent Long Patch Base Excision Repair (Danio rerio)", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "REACT:R-CFA-8979227", "l": "Triglyceride metabolism (Canis familiaris)", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "REACT:R-MMU-912694", "l": "Regulation of IFNA/IFNB signaling (Mus musculus)", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "REACT:R-CFA-5223345", "l": "Miscellaneous transport and binding events (Canis familiaris)", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0038915", "l": "De Novo Triacylglycerol Biosynthesis TG(a-25:0/17:0/17:0),Metabolic", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "REACT:R-HSA-9669917", "l": "Imatinib-resistant KIT mutants (Homo sapiens)", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0046254", "l": "Cardiolipin Biosynthesis CL(a-13:0/i-15:0/a-13:0/i-20:0),Disease", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0052825", "l": "Cardiolipin Biosynthesis CL(i-12:0/i-17:0/i-14:0/a-17:0),Disease", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "REACT:R-SSC-354194", "l": "GRB2:SOS provides linkage to MAPK signaling for Integrins (Sus scrofa)", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0061215", "l": "Cardiolipin Biosynthesis CL(i-14:0/a-15:0/a-17:0/a-25:0),Disease", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "REACT:R-DRE-2173793", "l": "Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer (Danio rerio)", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0053308", "l": "Cardiolipin Biosynthesis CL(i-12:0/i-18:0/i-24:0/a-15:0),Disease", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "REACT:R-SSC-77286", "l": "mitochondrial fatty acid beta-oxidation of saturated fatty acids (Sus scrofa)", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "REACT:R-DDI-983695", "l": "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers (Dictyostelium discoideum)", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "REACT:R-GGA-201451", "l": "Signaling by BMP (Gallus gallus)", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0032169", "l": "De Novo Triacylglycerol Biosynthesis TG(10:0/i-15:0/i-15:0),Metabolic", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "REACT:R-BTA-381771", "l": "Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) (Bos taurus)", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "REACT:R-GGA-5656169", "l": "Termination of translesion DNA synthesis (Gallus gallus)", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "REACT:R-SPO-8856825", "l": "Cargo recognition for clathrin-mediated endocytosis (Schizosaccharomyces pombe)", "d": []}]} {"type": "biolink:Pathway", "identifiers": 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"biolink:Pathway", "ic": "84.75972595860604", "identifiers": [{"i": "GO:0038184", "l": "cell surface bile acid receptor signaling pathway", "d": ["The series of molecular signals initiated by binding of a bile acid to a receptor on the surface of a cell, and ending with the regulation of a downstream cellular process, e.g. transcription."]}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0026739", "l": "De Novo Triacylglycerol Biosynthesis TG(8:0/19:0/15:0),Metabolic", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "REACT:R-XTR-2559582", "l": "Senescence-Associated Secretory Phenotype (SASP) (Xenopus tropicalis)", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "REACT:R-BTA-6783310", "l": "Fanconi Anemia Pathway (Bos taurus)", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "REACT:R-XTR-166665", "l": "Terminal pathway of complement (Xenopus tropicalis)", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": 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"SMPDB:SMP0040115", "l": "De Novo Triacylglycerol Biosynthesis TG(i-20:0/20:0/a-25:0),Metabolic", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "REACT:R-DRE-69620", "l": "Cell Cycle Checkpoints (Danio rerio)", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "REACT:R-CEL-418885", "l": "DCC mediated attractive signaling (Caenorhabditis elegans)", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0056183", "l": "Cardiolipin Biosynthesis CL(i-13:0/a-17:0/i-21:0/a-17:0),Disease", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0016498", "l": "De Novo Triacylglycerol Biosynthesis TG(14:0/20:1(11Z)/14:1(9Z)),Metabolic", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0062696", "l": "Cardiolipin Biosynthesis CL(i-14:0/i-15:0/a-21:0/a-21:0),Disease", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0060041", "l": "Cardiolipin Biosynthesis CL(i-13:0/i-21:0/i-17:0/a-21:0),Disease", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0028420", "l": "Cardiolipin Biosynthesis CL(18:1(11Z)/16:0/18:1(11Z)/18:1(9Z)),Metabolic", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0063008", "l": "Cardiolipin Biosynthesis CL(i-14:0/i-16:0/a-15:0/i-24:0),Disease", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0059368", "l": "Cardiolipin Biosynthesis CL(i-13:0/i-19:0/i-16:0/i-15:0),Disease", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0042259", "l": "De Novo Triacylglycerol Biosynthesis TG(i-22:0/i-17:0/a-13:0),Metabolic", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0040369", "l": "De Novo Triacylglycerol Biosynthesis TG(i-20:0/i-12:0/21:0),Metabolic", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0062218", "l": "Cardiolipin Biosynthesis CL(i-14:0/i-13:0/i-19:0/i-22:0),Disease", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0044675", "l": "Cardiolipin Biosynthesis CL(a-13:0/a-21:0/a-17:0/i-16:0),Disease", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0046604", "l": "Cardiolipin Biosynthesis CL(a-13:0/i-16:0/a-17:0/i-12:0),Disease", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0046831", "l": "Cardiolipin Biosynthesis CL(a-13:0/i-16:0/i-21:0/i-24:0),Disease", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "REACT:R-MMU-75094", "l": "Formation of the Editosome (Mus musculus)", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0026790", "l": "De Novo Triacylglycerol Biosynthesis TG(10:0/21:0/17:0),Metabolic", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "REACT:R-CFA-9609523", "l": "Insertion of tail-anchored proteins into the endoplasmic reticulum membrane (Canis familiaris)", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0062939", "l": "Cardiolipin Biosynthesis CL(i-14:0/i-15:0/i-24:0/a-15:0),Disease", "d": []}]} {"type": "biolink:Pathway", "ic": "100", "identifiers": [{"i": "GO:0034263", "l": "positive regulation of autophagy in response to ER overload", "d": ["The process in which the accumulation of misfolded proteins in the endoplasmic reticulum triggers a response that positively regulates autophagy."]}]} {"type": "biolink:Pathway", "identifiers": [{"i": "REACT:R-SCE-72662", "l": "Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S (Saccharomyces cerevisiae)", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "REACT:R-HSA-1839117", "l": "Signaling by cytosolic FGFR1 fusion mutants (Homo sapiens)", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0049975", "l": "Cardiolipin Biosynthesis CL(i-12:0/a-15:0/i-17:0/i-16:0),Disease", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0055688", "l": "Cardiolipin Biosynthesis 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conveyed from the cell surface to trigger the apoptotic death of a cell. 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In addition, eIF2alpha phosphorylation preferentially increases the translation of selective mRNAs such as ATF4 (activating transcription factor 4), which up regulates a subset of UPR genes required to restore folding capacity."]}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0054490", "l": "Cardiolipin Biosynthesis CL(i-12:0/i-22:0/i-16:0/i-24:0),Disease", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0054837", "l": "Cardiolipin Biosynthesis CL(i-12:0/i-24:0/i-18:0/i-13:0),Disease", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0000572", "l": "Fanconi-Bickel Syndrome,Disease", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0049550", "l": "Cardiolipin Biosynthesis CL(i-12:0/a-13:0/a-25:0/i-20:0),Disease", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "REACT:R-CFA-2871809", "l": "FCERI mediated Ca+2 mobilization (Canis familiaris)", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0015030", "l": "Phosphatidylcholine Biosynthesis PC(24:1(15Z)/16:0),Metabolic", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "REACT:R-SPO-141405", "l": "Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components (Schizosaccharomyces pombe)", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0055318", "l": "Cardiolipin Biosynthesis CL(i-13:0/a-13:0/a-17:0/a-15:0),Disease", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "REACT:R-HSA-1299316", "l": "TWIK-releated acid-sensitive K+ channel (TASK) (Homo sapiens)", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0045993", "l": "Cardiolipin Biosynthesis CL(a-13:0/i-14:0/a-25:0/a-25:0),Disease", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0062395", "l": "Cardiolipin Biosynthesis CL(i-14:0/i-14:0/a-25:0/i-19:0),Disease", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0042423", "l": "De Novo Triacylglycerol Biosynthesis TG(i-22:0/i-24:0/13:0),Metabolic", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0056104", "l": "Cardiolipin Biosynthesis CL(i-13:0/a-17:0/i-16:0/i-20:0),Disease", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "REACT:R-MMU-189085", "l": "Digestion of dietary carbohydrate (Mus musculus)", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "REACT:R-DME-5674499", "l": "Negative feedback regulation of MAPK pathway (Drosophila melanogaster)", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0043831", "l": "Cardiolipin Biosynthesis CL(a-13:0/a-13:0/i-16:0/i-14:0),Disease", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0053471", "l": "Cardiolipin Biosynthesis CL(i-12:0/i-19:0/i-14:0/a-17:0),Disease", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0050802", "l": "Cardiolipin Biosynthesis CL(i-12:0/a-25:0/a-17:0/i-17:0),Disease", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0049659", "l": "Cardiolipin Biosynthesis CL(i-12:0/a-13:0/i-17:0/i-24:0),Disease", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0057724", "l": "Cardiolipin Biosynthesis CL(i-13:0/i-14:0/i-16:0/a-25:0),Disease", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0000239", "l": "Saccharopinuria/Hyperlysinemia II,Disease", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "REACT:R-BTA-3134973", "l": "LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production (Bos taurus)", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "REACT:R-DDI-187687", "l": "Signalling to ERKs (Dictyostelium discoideum)", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "REACT:R-HSA-9837092", "l": "FASTK family proteins regulate processing and stability of mitochondrial RNAs (Homo sapiens)", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "REACT:R-RNO-77588", "l": "SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs (Rattus norvegicus)", "d": []}]} {"type": "biolink:Pathway", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0010018", "l": "far-red light signaling pathway", "d": ["The series of molecular signals initiated upon sensing of far red light by a photoreceptor molecule. Far red light is electromagnetic radiation of wavelength 700-800nm. An example of this response is seen at the beginning of many plant species developmental stages. These include germination, and the point when cotyledon expansion is triggered. In certain species these processes take place in response to absorption of red light by the pigment molecule phytochrome, but the signal can be reversed by exposure to far red light. During the initial phase the phytochrome molecule is only present in the red light absorbing form, but on absorption of red light it changes to a far red light absorbing form, triggering progress through development. An immediate short period of exposure to far red light entirely returns the pigment to its initial state and prevents triggering of the developmental process. A thirty minute break between red and subsequent far red light exposure renders the red light effect irreversible, and development then occurs regardless of whether far red light exposure subsequently occurs."]}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0043180", "l": "De Novo Triacylglycerol Biosynthesis TG(i-24:0/i-19:0/15:0),Metabolic", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "REACT:R-HSA-6791312", "l": "TP53 Regulates Transcription of Cell Cycle Genes (Homo sapiens)", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0058417", "l": "Cardiolipin Biosynthesis CL(i-13:0/i-16:0/i-18:0/i-22:0),Disease", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "REACT:R-MMU-1660662", "l": "Glycosphingolipid metabolism (Mus musculus)", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0061474", "l": "Cardiolipin Biosynthesis CL(i-14:0/a-15:0/i-24:0/i-19:0),Disease", "d": []}]} {"type": "biolink:Pathway", 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Triacylglycerol Biosynthesis TG(20:0/22:0/i-12:0),Metabolic", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "REACT:R-DDI-9609507", "l": "Protein localization (Dictyostelium discoideum)", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "PANTHER.PATHWAY:P02750", "l": "Lipoate_biosynthesis", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0059132", "l": "Cardiolipin Biosynthesis CL(i-13:0/i-18:0/i-21:0/i-14:0),Disease", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "REACT:R-DME-166058", "l": "MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Drosophila melanogaster)", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0045699", "l": "Cardiolipin Biosynthesis CL(a-13:0/i-13:0/i-12:0/i-20:0),Disease", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "REACT:R-RNO-9018683", "l": "Biosynthesis of DPA-derived SPMs (Rattus norvegicus)", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0054116", "l": "Cardiolipin Biosynthesis CL(i-12:0/i-21:0/i-14:0/a-13:0),Disease", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0027648", "l": "Cardiolipin Biosynthesis CL(16:1(9Z)/18:1(11Z)/18:1(11Z)/18:1(9Z)),Metabolic", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0054443", "l": "Cardiolipin Biosynthesis CL(i-12:0/i-22:0/i-14:0/i-12:0),Disease", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0058075", "l": "Cardiolipin Biosynthesis CL(i-13:0/i-15:0/i-17:0/i-20:0),Disease", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0037702", "l": "De Novo Triacylglycerol Biosynthesis TG(8:0/i-18:0/22:0),Metabolic", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0017818", "l": "De Novo Triacylglycerol Biosynthesis TG(16:0/18:1(11Z)/22:1(13Z)),Metabolic", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "REACT:R-XTR-391906", "l": "Leukotriene receptors (Xenopus tropicalis)", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0045035", "l": "Cardiolipin Biosynthesis CL(a-13:0/a-25:0/a-25:0/i-17:0),Disease", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0043875", "l": "Cardiolipin Biosynthesis CL(a-13:0/a-13:0/i-18:0/i-22:0),Disease", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0035550", "l": "De Novo Triacylglycerol Biosynthesis TG(21:0/a-15:0/14:0),Metabolic", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0056283", "l": "Cardiolipin Biosynthesis CL(i-13:0/a-21:0/a-15:0/i-19:0),Disease", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "REACT:R-HSA-77111", "l": "Synthesis of Ketone Bodies (Homo sapiens)", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "REACT:R-SSC-166166", "l": "MyD88-independent TLR4 cascade (Sus scrofa)", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0056505", "l": "Cardiolipin Biosynthesis CL(i-13:0/a-21:0/i-21:0/a-13:0),Disease", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "REACT:R-HSA-1250347", "l": "SHC1 events in ERBB4 signaling (Homo sapiens)", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0042058", "l": "De Novo Triacylglycerol Biosynthesis TG(i-22:0/a-21:0/a-17:0),Metabolic", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0000067", "l": "Aspartate Metabolism,Metabolic", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "REACT:R-HSA-2644603", "l": "Signaling by NOTCH1 in Cancer (Homo sapiens)", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0059951", "l": "Cardiolipin Biosynthesis CL(i-13:0/i-21:0/i-12:0/a-15:0),Disease", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "REACT:R-RNO-1300645", "l": "Acrosome Reaction and Sperm:Oocyte Membrane Binding (Rattus norvegicus)", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "REACT:R-XTR-5654221", "l": "Phospholipase C-mediated cascade; FGFR2 (Xenopus tropicalis)", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "REACT:R-SSC-4419969", "l": "Depolymerization of the Nuclear Lamina (Sus scrofa)", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "REACT:R-BTA-8876725", "l": "Protein methylation (Bos taurus)", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "REACT:R-CFA-2142700", "l": "Synthesis of Lipoxins (LX) (Canis familiaris)", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "REACT:R-CFA-6796648", "l": "TP53 Regulates Transcription of DNA Repair Genes (Canis familiaris)", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0041878", "l": "De Novo Triacylglycerol Biosynthesis TG(i-22:0/21:0/20:0),Metabolic", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0055668", "l": "Cardiolipin Biosynthesis CL(i-13:0/a-15:0/a-21:0/i-16:0),Disease", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0016257", "l": "De Novo Triacylglycerol Biosynthesis TG(14:0/16:0/18:1(11Z)),Metabolic", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0050608", "l": "Cardiolipin Biosynthesis CL(i-12:0/a-21:0/i-16:0/i-21:0),Disease", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "REACT:R-BTA-5358508", "l": "Mismatch Repair (Bos taurus)", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0038910", "l": "De Novo Triacylglycerol Biosynthesis TG(a-25:0/17:0/12:0),Metabolic", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "REACT:R-HSA-9734009", "l": "Defective Intrinsic Pathway for Apoptosis (Homo sapiens)", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0051182", "l": "Cardiolipin Biosynthesis CL(i-12:0/i-12:0/i-12:0/i-18:0),Disease", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0057571", "l": "Cardiolipin Biosynthesis 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"SMPDB:SMP0027705", "l": "Cardiolipin Biosynthesis CL(16:1(9Z)/18:1(9Z)/18:1(9Z)/18:1(11Z)),Metabolic", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "REACT:R-DME-69278", "l": "Cell Cycle, Mitotic (Drosophila melanogaster)", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0059397", "l": "Cardiolipin Biosynthesis CL(i-13:0/i-19:0/i-18:0/a-15:0),Disease", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "REACT:R-CEL-3065679", "l": "SUMO is proteolytically processed (Caenorhabditis elegans)", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "REACT:R-GGA-525793", "l": "Myogenesis (Gallus gallus)", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "REACT:R-RNO-912526", "l": "Interleukin receptor SHC signaling (Rattus norvegicus)", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "REACT:R-MMU-444473", "l": "Formyl peptide receptors bind formyl peptides and many other ligands (Mus musculus)", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0039664", "l": "De Novo Triacylglycerol Biosynthesis TG(i-19:0/22:0/i-13:0),Metabolic", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0050558", "l": "Cardiolipin Biosynthesis CL(i-12:0/a-21:0/i-14:0/a-13:0),Disease", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "REACT:R-RNO-1660514", "l": "Synthesis of PIPs at the Golgi membrane (Rattus norvegicus)", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0040504", "l": "De Novo Triacylglycerol Biosynthesis TG(i-20:0/i-17:0/10:0),Metabolic", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "REACT:R-SSC-8866423", "l": "VLDL assembly (Sus scrofa)", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0052488", "l": "Cardiolipin Biosynthesis CL(i-12:0/i-16:0/i-13:0/i-14:0),Disease", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "REACT:R-CFA-174184", "l": "Cdc20:Phospho-APC/C 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[{"i": "SMPDB:SMP0053273", "l": "Cardiolipin Biosynthesis CL(i-12:0/i-18:0/i-21:0/a-17:0),Disease", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "REACT:R-CFA-9762114", "l": "GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 (Canis familiaris)", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "REACT:R-MMU-8854521", "l": "Interaction between PHLDA1 and AURKA (Mus musculus)", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0026662", "l": "De Novo Triacylglycerol Biosynthesis TG(8:0/12:0/21:0),Metabolic", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0050193", "l": "Cardiolipin Biosynthesis CL(i-12:0/a-17:0/a-25:0/i-18:0),Disease", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0046093", "l": "Cardiolipin Biosynthesis CL(a-13:0/i-14:0/i-16:0/i-21:0),Disease", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0052648", "l": "Cardiolipin Biosynthesis 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In this pathway, the activated receptor signals via downstream effectors that result in the inhibition of beta-catenin phosphorylation, thereby preventing degradation of beta-catenin. 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{"type": "biolink:Pathway", "identifiers": [{"i": "REACT:R-XTR-168138", "l": "Toll Like Receptor 9 (TLR9) Cascade (Xenopus tropicalis)", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0041337", "l": "De Novo Triacylglycerol Biosynthesis TG(i-21:0/i-15:0/i-14:0),Metabolic", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "REACT:R-BTA-1632852", "l": "Macroautophagy (Bos taurus)", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0037921", "l": "De Novo Triacylglycerol Biosynthesis TG(a-21:0/12:0/i-22:0),Metabolic", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "REACT:R-DRE-948021", "l": "Transport to the Golgi and subsequent modification (Danio rerio)", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0054558", "l": "Cardiolipin Biosynthesis CL(i-12:0/i-22:0/i-20:0/i-20:0),Disease", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "REACT:R-XTR-190872", "l": "Transport of connexons 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CL(i-12:0/i-22:0/i-12:0/a-21:0),Disease", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "REACT:R-GGA-1912420", "l": "Pre-NOTCH Processing in Golgi (Gallus gallus)", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0040055", "l": "De Novo Triacylglycerol Biosynthesis TG(i-20:0/18:0/a-17:0),Metabolic", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0016575", "l": "De Novo Triacylglycerol Biosynthesis TG(14:0/24:1(15Z)/18:0),Metabolic", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "REACT:R-RNO-1489509", "l": "DAG and IP3 signaling (Rattus norvegicus)", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0033469", "l": "De Novo Triacylglycerol Biosynthesis TG(19:0/a-21:0/i-17:0),Metabolic", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "REACT:R-CFA-193775", "l": "Synthesis of bile acids and bile salts via 24-hydroxycholesterol (Canis familiaris)", "d": []}]} {"type": 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{"type": "biolink:Pathway", "identifiers": [{"i": "REACT:R-DME-168181", "l": "Toll Like Receptor 7/8 (TLR7/8) Cascade (Drosophila melanogaster)", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0047856", "l": "Cardiolipin Biosynthesis CL(a-13:0/i-20:0/a-13:0/a-15:0),Disease", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0052737", "l": "Cardiolipin Biosynthesis CL(i-12:0/i-17:0/a-17:0/a-25:0),Disease", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0054080", "l": "Cardiolipin Biosynthesis CL(i-12:0/i-21:0/i-12:0/a-13:0),Disease", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "REACT:R-RNO-196849", "l": "Metabolism of water-soluble vitamins and cofactors (Rattus norvegicus)", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0050820", "l": "Cardiolipin Biosynthesis CL(i-12:0/a-25:0/a-21:0/i-17:0),Disease", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": 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[]}]} {"type": "biolink:Pathway", "ic": "100", "identifiers": [{"i": "GO:0039585", "l": "PKR-mediated signaling", "d": ["A series of reactions in which a signal is passed on to downstream proteins within the cell via PKR (also known as EIF2AK2), an intracellular protein kinase that is activated by stress signals or upon binding to double-stranded RNA (dsRNA), followed by autophosphorylation. PKR plays a role in the antiviral response, phosphorylating proteins such as the translation initiation factor eIF2 to inhibit protein synthesis during viral infection. Begins with activation of PKR activity, and ends with regulation of a downstream cellular process, e.g. regulation of transcription or inhibition of translation."]}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0061837", "l": "Cardiolipin Biosynthesis CL(i-14:0/i-12:0/i-16:0/i-17:0),Disease", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0036524", "l": "De Novo Triacylglycerol Biosynthesis TG(22:0/i-13:0/a-25:0),Metabolic", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0044061", "l": "Cardiolipin Biosynthesis CL(a-13:0/a-15:0/a-25:0/a-21:0),Disease", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0017024", "l": "De Novo Triacylglycerol Biosynthesis TG(15:0/20:0/15:0),Metabolic", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0039961", "l": "De Novo Triacylglycerol Biosynthesis TG(i-20:0/15:0/19:0),Metabolic", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0060903", "l": "Cardiolipin Biosynthesis CL(i-14:0/a-13:0/a-21:0/a-13:0),Disease", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0047707", "l": "Cardiolipin Biosynthesis CL(a-13:0/i-19:0/i-16:0/i-21:0),Disease", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "REACT:R-SPO-5620971", "l": "Pyroptosis (Schizosaccharomyces pombe)", "d": []}]} {"type": "biolink:Pathway", "ic": "89.347505587204751", "identifiers": [{"i": "GO:0035329", "l": "hippo signaling", "d": ["The series of molecular signals mediated by the serine/threonine kinase Hippo or one of its orthologs. In Drosophila, Hippo in complex with the scaffold protein Salvador (Sav), phosphorylates and activates Warts (Wts), which in turn phosphorylates and inactivates the Yorkie (Yki) transcriptional activator. The core fly components hippo, sav, wts and mats are conserved in mammals as STK4/3 (MST1/2), SAV1/WW45, LATS1/2 and MOB1."]}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0058810", "l": "Cardiolipin Biosynthesis CL(i-13:0/i-17:0/i-22:0/i-16:0),Disease", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0044068", "l": "Cardiolipin Biosynthesis CL(a-13:0/a-15:0/a-25:0/i-17:0),Disease", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0036508", "l": "De Novo Triacylglycerol Biosynthesis TG(22:0/i-13:0/10:0),Metabolic", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "REACT:R-MMU-8847453", "l": "Synthesis of PIPs in the nucleus (Mus musculus)", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0054578", "l": "Cardiolipin Biosynthesis CL(i-12:0/i-22:0/i-21:0/i-22:0),Disease", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "REACT:R-SCE-351143", "l": "Agmatine biosynthesis (Saccharomyces cerevisiae)", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0026156", "l": "De Novo Triacylglycerol Biosynthesis TG(20:0/16:0/18:0),Metabolic", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "REACT:R-SPO-1280215", "l": "Cytokine Signaling in Immune system (Schizosaccharomyces pombe)", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0052326", "l": "Cardiolipin Biosynthesis CL(i-12:0/i-15:0/i-22:0/i-13:0),Disease", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0048784", "l": "Cardiolipin Biosynthesis CL(a-13:0/i-22:0/i-24:0/a-15:0),Disease", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "REACT:R-HSA-9669933", "l": "Signaling by kinase domain mutants of KIT (Homo sapiens)", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0054158", "l": "Cardiolipin Biosynthesis CL(i-12:0/i-21:0/i-16:0/i-13:0),Disease", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "REACT:R-CFA-450321", "l": "JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Canis familiaris)", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0015003", "l": "Phosphatidylcholine Biosynthesis PC(24:0/18:0),Metabolic", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0040919", "l": "De Novo Triacylglycerol Biosynthesis TG(i-21:0/18:0/19:0),Metabolic", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "REACT:R-DRE-453274", "l": "Mitotic G2-G2/M phases (Danio rerio)", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0046139", "l": "Cardiolipin Biosynthesis CL(a-13:0/i-14:0/i-19:0/i-13:0),Disease", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0000343", "l": "Intracellular Signalling Through PGD2 receptor and Prostaglandin D2,Signaling,PGD is the major prostanoid released from human mast cells upon immunological challenge. 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{"type": "biolink:Pathway", "identifiers": [{"i": "REACT:R-CFA-379724", "l": "tRNA Aminoacylation (Canis familiaris)", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0020646", "l": "De Novo Triacylglycerol Biosynthesis TG(14:1(9Z)/14:0/24:1(15Z)),Metabolic", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "REACT:R-XTR-157118", "l": "Signaling by NOTCH (Xenopus tropicalis)", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0062681", "l": "Cardiolipin Biosynthesis CL(i-14:0/i-15:0/a-17:0/i-13:0),Disease", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0057057", "l": "Cardiolipin Biosynthesis CL(i-13:0/i-12:0/i-15:0/i-17:0),Disease", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0038772", "l": "De Novo Triacylglycerol Biosynthesis TG(a-25:0/12:0/19:0),Metabolic", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0060156", "l": "Cardiolipin Biosynthesis 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Triacylglycerol Biosynthesis TG(21:0/13:0/i-19:0),Metabolic", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "REACT:R-CFA-8854214", "l": "TBC/RABGAPs (Canis familiaris)", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0061924", "l": "Cardiolipin Biosynthesis CL(i-14:0/i-12:0/i-21:0/i-14:0),Disease", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "REACT:R-BTA-373752", "l": "Netrin-1 signaling (Bos taurus)", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "REACT:R-CFA-180786", "l": "Extension of Telomeres (Canis familiaris)", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "REACT:R-DME-76042", "l": "RNA Polymerase II Transcription Initiation And Promoter Clearance (Drosophila melanogaster)", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "REACT:R-GGA-2028269", "l": "Signaling by Hippo (Gallus gallus)", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0052931", "l": "Cardiolipin Biosynthesis CL(i-12:0/i-17:0/i-20:0/a-15:0),Disease", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "REACT:R-XTR-2022854", "l": "Keratan sulfate biosynthesis (Xenopus tropicalis)", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0037944", "l": "De Novo Triacylglycerol Biosynthesis TG(a-21:0/13:0/i-16:0),Metabolic", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0044567", "l": "Cardiolipin Biosynthesis CL(a-13:0/a-17:0/i-21:0/i-16:0),Disease", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0035830", "l": "De Novo Triacylglycerol Biosynthesis TG(21:0/i-17:0/i-17:0),Metabolic", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0036322", "l": "De Novo Triacylglycerol Biosynthesis TG(22:0/8:0/i-12:0),Metabolic", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0057425", "l": "Cardiolipin Biosynthesis CL(i-13:0/i-13:0/i-18:0/a-17:0),Disease", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0045571", "l": "Cardiolipin Biosynthesis CL(a-13:0/i-12:0/i-24:0/i-15:0),Disease", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0026567", "l": "De Novo Triacylglycerol Biosynthesis TG(22:0/21:0/17:0),Metabolic", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "REACT:R-BTA-193639", "l": "p75NTR signals via NF-kB (Bos taurus)", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0026782", "l": "De Novo Triacylglycerol Biosynthesis TG(10:0/13:0/19:0),Metabolic", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "REACT:R-RNO-425381", "l": "Bicarbonate transporters (Rattus norvegicus)", "d": []}]} {"type": "biolink:Pathway", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0031569", "l": "mitotic G2 cell size control checkpoint signaling", "d": ["A signal transduction process that contributes to a cell size control checkpoint prior to the G2/M transition of mitosis."]}]} {"type": "biolink:Pathway", "identifiers": [{"i": "REACT:R-DME-450282", "l": "MAPK targets/ Nuclear events mediated by MAP kinases (Drosophila melanogaster)", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "REACT:R-DRE-68886", "l": "M Phase (Danio rerio)", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0014276", "l": "Phosphatidylcholine Biosynthesis PC(15:0/15:0),Metabolic", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0057184", "l": "Cardiolipin Biosynthesis CL(i-13:0/i-12:0/i-22:0/i-19:0),Disease", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "REACT:R-SSC-2871796", "l": "FCERI mediated MAPK activation (Sus scrofa)", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "REACT:R-GGA-168249", "l": "Innate Immune System (Gallus gallus)", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0041438", "l": "De Novo Triacylglycerol Biosynthesis 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"REACT:R-XTR-425397", "l": "Transport of vitamins, nucleosides, and related molecules (Xenopus tropicalis)", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0026548", "l": "De Novo Triacylglycerol Biosynthesis TG(22:0/13:0/16:0),Metabolic", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0053197", "l": "Cardiolipin Biosynthesis CL(i-12:0/i-18:0/i-16:0/i-22:0),Disease", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "REACT:R-RNO-446203", "l": "Asparagine N-linked glycosylation (Rattus norvegicus)", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0047355", "l": "Cardiolipin Biosynthesis CL(a-13:0/i-18:0/i-15:0/a-21:0),Disease", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0041469", "l": "De Novo Triacylglycerol Biosynthesis TG(i-21:0/i-20:0/18:0),Metabolic", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0062022", "l": "Cardiolipin Biosynthesis 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The pathway coordinates chromosome segregation with mitotic exit and cytokinesis."]}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0036051", "l": "De Novo Triacylglycerol Biosynthesis TG(22:0/13:0/i-13:0),Metabolic", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "REACT:R-RNO-1222556", "l": "ROS and RNS production in phagocytes (Rattus norvegicus)", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "REACT:R-XTR-1538133", "l": "G0 and Early G1 (Xenopus tropicalis)", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "REACT:R-BTA-2028269", "l": "Signaling by Hippo (Bos taurus)", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0054139", "l": "Cardiolipin Biosynthesis CL(i-12:0/i-21:0/i-15:0/i-12:0),Disease", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0046780", "l": "Cardiolipin Biosynthesis CL(a-13:0/i-16:0/i-19:0/a-15:0),Disease", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "REACT:R-XTR-8963899", "l": "Plasma lipoprotein remodeling (Xenopus tropicalis)", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0058605", "l": "Cardiolipin Biosynthesis CL(i-13:0/i-17:0/a-25:0/i-15:0),Disease", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0035765", "l": "De Novo Triacylglycerol Biosynthesis TG(21:0/i-15:0/a-21:0),Metabolic", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0060066", "l": "Cardiolipin Biosynthesis CL(i-13:0/i-21:0/i-18:0/i-16:0),Disease", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0062648", "l": "Cardiolipin Biosynthesis CL(i-14:0/i-15:0/a-13:0/i-16:0),Disease", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0057510", "l": "Cardiolipin Biosynthesis CL(i-13:0/i-13:0/i-22:0/i-22:0),Disease", "d": []}]} {"type": "biolink:Pathway", "ic": "100", "identifiers": [{"i": "GO:0071848", "l": "positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling", "d": ["Any TNFSF11-mediated signaling process that increases the rate, frequency, or extent of the ERK1 and ERK2 cascade."]}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0040695", "l": "De Novo Triacylglycerol Biosynthesis TG(i-20:0/i-24:0/a-21:0),Metabolic", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0039587", "l": "De Novo Triacylglycerol Biosynthesis TG(a-25:0/i-24:0/21:0),Metabolic", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0061490", "l": "Cardiolipin Biosynthesis CL(i-14:0/a-17:0/a-13:0/i-14:0),Disease", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "REACT:R-MMU-2022923", "l": "Dermatan sulfate biosynthesis (Mus musculus)", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0043116", "l": "De Novo Triacylglycerol Biosynthesis TG(i-24:0/i-16:0/i-21:0),Metabolic", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "REACT:R-BTA-77348", "l": "Beta oxidation of octanoyl-CoA to hexanoyl-CoA (Bos taurus)", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0033987", "l": "De Novo Triacylglycerol Biosynthesis TG(20:0/a-17:0/15:0),Metabolic", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "REACT:R-HSA-9772573", "l": "Late SARS-CoV-2 Infection Events (Homo sapiens)", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "REACT:R-HSA-111452", "l": "Activation and oligomerization of BAK protein (Homo sapiens)", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0039033", "l": "De Novo Triacylglycerol Biosynthesis TG(a-25:0/21:0/19:0),Metabolic", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0040977", "l": "De Novo Triacylglycerol Biosynthesis TG(i-21:0/20:0/19:0),Metabolic", "d": []}]} {"type": "biolink:Pathway", "ic": "100", "identifiers": [{"i": "GO:0021881", "l": "Wnt-activated signaling pathway involved in forebrain neuron fate commitment", "d": ["The series of molecular signals initiated by binding of Wnt protein to a receptor on the surface of the target cell that contributes to the commitment of a neuroblast to aneuronal fate. The neuron will reside in the forebrain."]}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0061760", "l": "Cardiolipin Biosynthesis CL(i-14:0/i-12:0/i-12:0/a-25:0),Disease", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0043296", "l": "De Novo Triacylglycerol Biosynthesis TG(i-24:0/i-24:0/15:0),Metabolic", "d": []}]} {"type": "biolink:Pathway", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0099105", "l": "ion channel modulating, G protein-coupled receptor signaling pathway", "d": ["The series of molecular signals generated as a consequence of a G protein-coupled receptor binding to its physiological ligand, where the pathway proceeds through activation or inhibition of an ion channel."]}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0058634", "l": "Cardiolipin Biosynthesis CL(i-13:0/i-17:0/i-13:0/a-15:0),Disease", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0051676", "l": "Cardiolipin 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{"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0046753", "l": "Cardiolipin Biosynthesis CL(a-13:0/i-16:0/i-17:0/i-17:0),Disease", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0062427", "l": "Cardiolipin Biosynthesis CL(i-14:0/i-14:0/i-13:0/i-15:0),Disease", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0040405", "l": "De Novo Triacylglycerol Biosynthesis TG(i-20:0/i-13:0/a-25:0),Metabolic", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "REACT:R-SSC-170984", "l": "ARMS-mediated activation (Sus scrofa)", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0045428", "l": "Cardiolipin Biosynthesis CL(a-13:0/i-12:0/i-15:0/i-16:0),Disease", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0057734", "l": "Cardiolipin Biosynthesis CL(i-13:0/i-14:0/i-16:0/i-21:0),Disease", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0039406", "l": "De Novo 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[]}]} {"type": "biolink:Pathway", "identifiers": [{"i": "REACT:R-RNO-8941855", "l": "RUNX3 regulates CDKN1A transcription (Rattus norvegicus)", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "REACT:R-CFA-5250924", "l": "B-WICH complex positively regulates rRNA expression (Canis familiaris)", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0032066", "l": "De Novo Triacylglycerol Biosynthesis TG(10:0/i-12:0/16:0),Metabolic", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "REACT:R-BTA-141333", "l": "Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB (Bos taurus)", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0038276", "l": "De Novo Triacylglycerol Biosynthesis TG(a-21:0/a-15:0/17:0),Metabolic", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "REACT:R-CEL-5654716", "l": "Downstream signaling of activated FGFR4 (Caenorhabditis elegans)", "d": []}]} {"type": "biolink:Pathway", 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Binding of acetylcholine to a G protein-coupled acetylcholine receptor (muscarinic receptor) on the surface of the signal-receiving cell results in liberation of the G-beta/gamma complex from the alpha subunit. The G-beta/gamma complex binds directly to the inward-rectifying potassium channel IKACh. Once the ion channel is activated, potassium ions (K+) flow out of the cell and cause it to hyperpolarize. 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{"type": "biolink:Pathway", "identifiers": [{"i": "REACT:R-BTA-1461957", "l": "Beta defensins (Bos taurus)", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0035448", "l": "De Novo Triacylglycerol Biosynthesis TG(21:0/19:0/i-22:0),Metabolic", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "REACT:R-DDI-5689880", "l": "Ub-specific processing proteases (Dictyostelium discoideum)", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "REACT:R-HSA-3065676", "l": "SUMO is conjugated to E1 (UBA2:SAE1) (Homo sapiens)", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0031785", "l": "De Novo Triacylglycerol Biosynthesis TG(10:0/15:0/i-24:0),Metabolic", "d": []}]} {"type": "biolink:Pathway", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0060823", "l": "canonical Wnt signaling pathway involved in neural plate anterior/posterior pattern formation", "d": ["The series of molecular signals initiated by binding of a Wnt protein 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CL(i-13:0/a-17:0/i-19:0/a-21:0),Disease", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0015858", "l": "Phosphatidylethanolamine Biosynthesis PE(24:0/22:0),Metabolic", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0035585", "l": "De Novo Triacylglycerol Biosynthesis TG(21:0/a-17:0/20:0),Metabolic", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0020926", "l": "De Novo Triacylglycerol Biosynthesis TG(14:1(9Z)/24:1(15Z)/24:1(15Z)),Metabolic", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "REACT:R-DME-159230", "l": "Transport of the SLBP Dependant Mature mRNA (Drosophila melanogaster)", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0026857", "l": "De Novo Triacylglycerol Biosynthesis TG(8:0/21:0/19:0),Metabolic", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "REACT:R-HSA-9702605", "l": "pexidartinib-resistant FLT3 mutants (Homo sapiens)", "d": []}]} {"type": 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"biolink:Pathway", "identifiers": [{"i": "REACT:R-SCE-4420097", "l": "VEGFA-VEGFR2 Pathway (Saccharomyces cerevisiae)", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0042378", "l": "De Novo Triacylglycerol Biosynthesis TG(i-22:0/i-21:0/a-21:0),Metabolic", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "REACT:R-SSC-73817", "l": "Purine ribonucleoside monophosphate biosynthesis (Sus scrofa)", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "REACT:R-CEL-139853", "l": "Elevation of cytosolic Ca2+ levels (Caenorhabditis elegans)", "d": []}]} {"type": "biolink:Pathway", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0010161", "l": "red light signaling pathway", "d": ["The series of molecular signals initiated upon sensing of red light by a photoreceptor molecule. Red light is electromagnetic radiation of wavelength of 580-700nm. An example of this response is seen at the beginning of many plant species developmental stages. These include germination, and the point when cotyledon expansion is triggered. In certain species these processes take place in response to absorption of red light by the pigment molecule phytochrome, but the signal can be reversed by exposure to far red light. During the initial phase the phytochrome molecule is only present in the red light absorbing form, but on absorption of red light it changes to a far red light absorbing form, triggering progress through development. An immediate short period of exposure to far red light entirely returns the pigment to its initial state and prevents triggering of the developmental process. 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In this pathway, the activated receptor signals via downstream effectors that result in the inhibition of beta-catenin phosphorylation, thereby preventing degradation of beta-catenin. 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{"type": "biolink:Pathway", "identifiers": [{"i": "REACT:R-RNO-1461973", "l": "Defensins (Rattus norvegicus)", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "REACT:R-XTR-141424", "l": "Amplification of signal from the kinetochores (Xenopus tropicalis)", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0054720", "l": "Cardiolipin Biosynthesis CL(i-12:0/i-24:0/a-25:0/i-22:0),Disease", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "REACT:R-DRE-442729", "l": "CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde (Danio rerio)", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0043208", "l": "De Novo Triacylglycerol Biosynthesis TG(i-24:0/i-20:0/14:0),Metabolic", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0051630", "l": "Cardiolipin Biosynthesis CL(i-12:0/i-13:0/i-19:0/i-16:0),Disease", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "REACT:R-SCE-6811442", "l": "Intra-Golgi and retrograde Golgi-to-ER traffic (Saccharomyces cerevisiae)", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "REACT:R-CFA-1234174", "l": "Cellular response to hypoxia (Canis familiaris)", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0052270", "l": "Cardiolipin Biosynthesis CL(i-12:0/i-15:0/i-19:0/a-25:0),Disease", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "REACT:R-RNO-5693616", "l": "Presynaptic phase of homologous DNA pairing and strand exchange (Rattus norvegicus)", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0062450", "l": "Cardiolipin Biosynthesis CL(i-14:0/i-14:0/i-14:0/i-20:0),Disease", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0044677", "l": "Cardiolipin Biosynthesis CL(a-13:0/a-21:0/a-17:0/i-18:0),Disease", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0061201", "l": "Cardiolipin Biosynthesis 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The AMY3 signaling pathway can also be initiated by the amyloid-beta complex. 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phosphorylation of CREB (Danio rerio)", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0046543", "l": "Cardiolipin Biosynthesis CL(a-13:0/i-15:0/i-24:0/i-22:0),Disease", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0063375", "l": "Cardiolipin Biosynthesis CL(i-14:0/i-17:0/i-14:0/a-17:0),Disease", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0014367", "l": "Phosphatidylcholine Biosynthesis PC(18:0/18:1(11Z)),Metabolic", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0036627", "l": "De Novo Triacylglycerol Biosynthesis TG(22:0/i-17:0/14:0),Metabolic", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "REACT:R-RNO-448706", "l": "Interleukin-1 processing (Rattus norvegicus)", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0055380", "l": "Cardiolipin Biosynthesis CL(i-13:0/a-13:0/i-12:0/i-15:0),Disease", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0060865", "l": "Cardiolipin Biosynthesis CL(i-14:0/a-13:0/a-13:0/i-24:0),Disease", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0016202", "l": "De Novo Triacylglycerol Biosynthesis TG(14:0/14:0/18:1(9Z)),Metabolic", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0014330", "l": "Phosphatidylcholine Biosynthesis PC(16:0/24:0),Metabolic", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "REACT:R-XTR-169911", "l": "Regulation of Apoptosis (Xenopus tropicalis)", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "REACT:R-BTA-9762114", "l": "GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 (Bos taurus)", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0037602", "l": "De Novo Triacylglycerol Biosynthesis TG(8:0/i-14:0/i-22:0),Metabolic", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0062704", "l": "Cardiolipin Biosynthesis 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"biolink:Pathway", "identifiers": [{"i": "REACT:R-DME-390696", "l": "Adrenoceptors (Drosophila melanogaster)", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0035785", "l": "De Novo Triacylglycerol Biosynthesis TG(21:0/i-16:0/17:0),Metabolic", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0039327", "l": "De Novo Triacylglycerol Biosynthesis TG(a-25:0/i-14:0/22:0),Metabolic", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "REACT:R-DRE-111471", "l": "Apoptotic factor-mediated response (Danio rerio)", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0041478", "l": "De Novo Triacylglycerol Biosynthesis TG(i-21:0/i-20:0/a-21:0),Metabolic", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "REACT:R-CEL-9639288", "l": "Amino acids regulate mTORC1 (Caenorhabditis elegans)", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0063100", "l": "Cardiolipin Biosynthesis 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{"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0047779", "l": "Cardiolipin Biosynthesis CL(a-13:0/i-19:0/i-20:0/i-21:0),Disease", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "REACT:R-HSA-389958", "l": "Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding (Homo sapiens)", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "REACT:R-DDI-597592", "l": "Post-translational protein modification (Dictyostelium discoideum)", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "REACT:R-XTR-210455", "l": "Astrocytic Glutamate-Glutamine Uptake And Metabolism (Xenopus tropicalis)", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0037284", "l": "De Novo Triacylglycerol Biosynthesis TG(8:0/18:0/i-21:0),Metabolic", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0041858", "l": "De Novo Triacylglycerol Biosynthesis TG(i-22:0/20:0/i-12:0),Metabolic", "d": []}]} {"type": "biolink:Pathway", 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"biolink:Pathway", "identifiers": [{"i": "REACT:R-HSA-5620920", "l": "Cargo trafficking to the periciliary membrane (Homo sapiens)", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0048251", "l": "Cardiolipin Biosynthesis CL(a-13:0/i-21:0/a-25:0/i-12:0),Disease", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0046350", "l": "Cardiolipin Biosynthesis CL(a-13:0/i-15:0/i-13:0/a-15:0),Disease", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0044211", "l": "Cardiolipin Biosynthesis CL(a-13:0/a-15:0/i-19:0/i-18:0),Disease", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0045312", "l": "Cardiolipin Biosynthesis CL(a-13:0/i-12:0/a-17:0/a-13:0),Disease", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "REACT:R-BTA-69002", "l": "DNA Replication Pre-Initiation (Bos taurus)", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "REACT:R-DRE-2514853", "l": "Condensation of Prometaphase Chromosomes (Danio rerio)", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0052219", "l": "Cardiolipin Biosynthesis CL(i-12:0/i-15:0/i-16:0/i-13:0),Disease", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0051488", "l": "Cardiolipin Biosynthesis CL(i-12:0/i-13:0/a-25:0/i-18:0),Disease", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0058162", "l": "Cardiolipin Biosynthesis CL(i-13:0/i-15:0/i-22:0/i-17:0),Disease", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0057407", "l": "Cardiolipin Biosynthesis CL(i-13:0/i-13:0/i-17:0/a-17:0),Disease", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "REACT:R-SCE-1169410", "l": "Antiviral mechanism by IFN-stimulated genes (Saccharomyces cerevisiae)", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0061497", "l": "Cardiolipin Biosynthesis CL(i-14:0/a-17:0/a-13:0/i-21:0),Disease", "d": []}]} {"type": 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[{"i": "SMPDB:SMP0018958", "l": "De Novo Triacylglycerol Biosynthesis TG(20:0/20:0/16:1(9Z)),Metabolic", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0051198", "l": "Cardiolipin Biosynthesis CL(i-12:0/i-12:0/i-13:0/i-16:0),Disease", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0026497", "l": "De Novo Triacylglycerol Biosynthesis TG(22:0/21:0/14:0),Metabolic", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0035609", "l": "De Novo Triacylglycerol Biosynthesis TG(21:0/a-21:0/15:0),Metabolic", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "REACT:R-RNO-445144", "l": "Signal transduction by L1 (Rattus norvegicus)", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0046041", "l": "Cardiolipin Biosynthesis CL(a-13:0/i-14:0/i-13:0/i-24:0),Disease", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "REACT:R-MMU-5693548", "l": "Sensing of DNA Double Strand Breaks (Mus musculus)", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0041566", "l": "De Novo Triacylglycerol Biosynthesis TG(i-21:0/i-24:0/a-21:0),Metabolic", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0049073", "l": "Cardiolipin Biosynthesis CL(a-13:0/i-24:0/i-21:0/a-21:0),Disease", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0038836", "l": "De Novo Triacylglycerol Biosynthesis TG(a-25:0/14:0/a-15:0),Metabolic", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "REACT:R-DRE-512988", "l": "Interleukin-3, Interleukin-5 and GM-CSF signaling (Danio rerio)", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "REACT:R-DDI-6811558", "l": "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Dictyostelium discoideum)", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0050794", "l": "Cardiolipin Biosynthesis CL(i-12:0/a-25:0/a-17:0/a-17:0),Disease", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0055951", "l": "Cardiolipin Biosynthesis CL(i-13:0/a-17:0/a-15:0/i-13:0),Disease", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0042708", "l": "De Novo Triacylglycerol Biosynthesis TG(i-24:0/19:0/i-20:0),Metabolic", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0043243", "l": "De Novo Triacylglycerol Biosynthesis TG(i-24:0/i-21:0/20:0),Metabolic", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0000259", "l": "Streptomycin Action Pathway,Drug Action", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "REACT:R-RNO-4641262", "l": "Disassembly of the destruction complex and recruitment of AXIN to the membrane (Rattus norvegicus)", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "REACT:R-HSA-1226099", "l": "Signaling by FGFR in disease (Homo sapiens)", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "REACT:R-GGA-2243919", "l": "Crosslinking of collagen fibrils (Gallus gallus)", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "REACT:R-DRE-418346", "l": "Platelet homeostasis (Danio rerio)", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "REACT:R-RNO-69278", "l": "Cell Cycle, Mitotic (Rattus norvegicus)", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "REACT:R-BTA-72731", "l": "Recycling of eIF2:GDP (Bos taurus)", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0055810", "l": "Cardiolipin Biosynthesis CL(i-13:0/a-15:0/i-18:0/i-14:0),Disease", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0061558", "l": "Cardiolipin Biosynthesis CL(i-14:0/a-17:0/i-13:0/a-21:0),Disease", "d": []}]} {"type": "biolink:Pathway", "ic": "100", "identifiers": [{"i": "GO:0034671", "l": "retinoic acid receptor signaling pathway involved in pronephros anterior/posterior pattern specification", "d": ["The series of molecular signals generated as a consequence of a retinoic acid receptor binding to one of its physiological ligands that results in the spatial identity of regions along the anterior-posterior axis of the pronephros."]}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0047467", "l": "Cardiolipin Biosynthesis CL(a-13:0/i-18:0/i-21:0/i-14:0),Disease", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0060456", "l": "Cardiolipin Biosynthesis CL(i-13:0/i-22:0/i-21:0/i-14:0),Disease", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0033624", "l": "De Novo Triacylglycerol Biosynthesis TG(20:0/12:0/i-14:0),Metabolic", "d": []}]} {"type": "biolink:Pathway", "ic": "69.58597274768276", "identifiers": [{"i": "GO:0002768", "l": "immune response-regulating cell surface receptor signaling pathway", "d": ["The series of molecular signals initiated by an extracellular ligand binding to a receptor on the surface of the target cell capable of activating, perpetuating, or inhibiting an immune response."]}]} {"type": "biolink:Pathway", "ic": "89.347505587204751", "identifiers": [{"i": "GO:0036498", "l": "IRE1-mediated unfolded protein response", "d": ["The series of molecular signals mediated by the endoplasmic reticulum stress sensor IRE1 (Inositol-requiring transmembrane kinase/endonuclease). 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(Canis familiaris)", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0059236", "l": "Cardiolipin Biosynthesis CL(i-13:0/i-19:0/a-17:0/a-17:0),Disease", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0050678", "l": "Cardiolipin Biosynthesis CL(i-12:0/a-21:0/i-20:0/i-19:0),Disease", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0002292", "l": "The Oncogenic Action of Succinate,Disease", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "REACT:R-DDI-500753", "l": "Pyrimidine biosynthesis (Dictyostelium discoideum)", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "REACT:R-MMU-913531", "l": "Interferon Signaling (Mus musculus)", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "REACT:R-DRE-77289", "l": "Mitochondrial Fatty Acid Beta-Oxidation (Danio rerio)", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0034292", "l": "De Novo Triacylglycerol Biosynthesis TG(20:0/i-19:0/i-14:0),Metabolic", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "REACT:R-DRE-8874081", "l": "MET activates PTK2 signaling (Danio rerio)", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "REACT:R-HSA-8856688", "l": "Golgi-to-ER retrograde transport (Homo sapiens)", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "REACT:R-RNO-69580", "l": "p53-Dependent G1/S DNA damage checkpoint (Rattus norvegicus)", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "REACT:R-SSC-997272", "l": "Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits (Sus scrofa)", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0017903", "l": "De Novo Triacylglycerol Biosynthesis TG(16:0/22:1(13Z)/22:0),Metabolic", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0036410", "l": "De Novo Triacylglycerol Biosynthesis TG(22:0/a-17:0/i-13:0),Metabolic", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0051902", "l": "Cardiolipin Biosynthesis CL(i-12:0/i-14:0/i-16:0/i-19:0),Disease", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0052241", "l": "Cardiolipin Biosynthesis CL(i-12:0/i-15:0/i-17:0/i-17:0),Disease", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0027500", "l": "Cardiolipin Biosynthesis CL(16:1(9Z)/16:0/18:1(11Z)/16:0),Metabolic", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0042047", "l": "De Novo Triacylglycerol Biosynthesis TG(i-22:0/a-21:0/15:0),Metabolic", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0042991", "l": "De Novo Triacylglycerol Biosynthesis TG(i-24:0/i-12:0/i-13:0),Metabolic", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "REACT:R-CFA-2142850", "l": "Hyaluronan biosynthesis and export (Canis familiaris)", "d": []}]} {"type": "biolink:Pathway", "ic": "77.488267285704651", "identifiers": [{"i": "GO:0140895", "l": "cell surface toll-like receptor signaling pathway", "d": ["The series of molecular signals initiated by a ligand binding to a cell surface pattern recognition receptor (PRR) of the toll-like family."]}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0018353", "l": "De Novo Triacylglycerol Biosynthesis TG(18:0/22:0/18:1(11Z)),Metabolic", "d": []}]} {"type": "biolink:Pathway", "ic": "100", "identifiers": [{"i": "GO:0003435", "l": "smoothened signaling pathway involved in growth plate cartilage chondrocyte development", "d": ["The series of molecular signals generated as a consequence of activation of the transmembrane protein Smoothened that contributes to the progression of a growth plate cartilage chondrocyte over time."]}]} {"type": "biolink:Pathway", "identifiers": [{"i": "REACT:R-DRE-141333", "l": "Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB (Danio rerio)", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0036050", "l": "De Novo Triacylglycerol Biosynthesis TG(22:0/13:0/i-12:0),Metabolic", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "REACT:R-CFA-9619229", "l": "Activation of RAC1 downstream of NMDARs (Canis familiaris)", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "REACT:R-DME-5654693", "l": "FRS-mediated FGFR1 signaling (Drosophila melanogaster)", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0060605", "l": "Cardiolipin Biosynthesis CL(i-13:0/i-24:0/a-25:0/i-19:0),Disease", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0000561", "l": "Fructosuria,Disease", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0057580", "l": "Dexbrompheniramine H1-Antihistamine Action,Drug Action", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0044562", "l": "Cardiolipin Biosynthesis CL(a-13:0/a-17:0/i-21:0/a-25:0),Disease", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0018397", "l": "De Novo Triacylglycerol Biosynthesis TG(18:0/14:1(9Z)/22:0),Metabolic", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "REACT:R-RNO-1483249", "l": "Inositol phosphate metabolism (Rattus norvegicus)", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0060864", "l": "Cardiolipin Biosynthesis CL(i-14:0/a-13:0/a-13:0/i-22:0),Disease", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0035661", "l": "De Novo Triacylglycerol Biosynthesis TG(21:0/a-25:0/i-22:0),Metabolic", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "REACT:R-CFA-445717", "l": "Aquaporin-mediated transport (Canis familiaris)", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0047974", "l": "Cardiolipin Biosynthesis CL(a-13:0/i-20:0/i-13:0/i-20:0),Disease", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0031861", "l": "De Novo Triacylglycerol Biosynthesis 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"REACT:R-CFA-76005", "l": "Response to elevated platelet cytosolic Ca2+ (Canis familiaris)", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "REACT:R-XTR-977347", "l": "Serine biosynthesis (Xenopus tropicalis)", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0057833", "l": "Cardiolipin Biosynthesis CL(i-13:0/i-14:0/i-22:0/i-13:0),Disease", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0048645", "l": "Cardiolipin Biosynthesis CL(a-13:0/i-22:0/i-15:0/i-12:0),Disease", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0050586", "l": "Cardiolipin Biosynthesis CL(i-12:0/a-21:0/i-15:0/i-17:0),Disease", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0032055", "l": "De Novo Triacylglycerol Biosynthesis TG(10:0/a-25:0/i-14:0),Metabolic", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0040108", "l": "De Novo Triacylglycerol Biosynthesis 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[{"i": "SMPDB:SMP0046260", "l": "Cardiolipin Biosynthesis CL(a-13:0/i-15:0/a-15:0/a-15:0),Disease", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "REACT:R-SSC-6804754", "l": "Regulation of TP53 Expression (Sus scrofa)", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "REACT:R-SSC-73887", "l": "Death Receptor Signaling (Sus scrofa)", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0051117", "l": "Cardiolipin Biosynthesis CL(i-12:0/i-12:0/a-17:0/a-13:0),Disease", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0034297", "l": "De Novo Triacylglycerol Biosynthesis TG(20:0/i-19:0/i-19:0),Metabolic", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0039270", "l": "De Novo Triacylglycerol Biosynthesis TG(a-25:0/i-12:0/8:0),Metabolic", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "REACT:R-HSA-5603027", "l": "IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR) (Homo sapiens)", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0062265", "l": "Cardiolipin Biosynthesis CL(i-14:0/i-13:0/i-22:0/i-15:0),Disease", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "REACT:R-HSA-9679504", "l": "Translation of Replicase and Assembly of the Replication Transcription Complex (Homo sapiens)", "d": []}]} {"type": "biolink:Pathway", "ic": "100", "identifiers": [{"i": "GO:0035660", "l": "MyD88-dependent toll-like receptor 4 signaling pathway", "d": ["The series of molecular signals initiated by a ligand binding to a toll-like 4 receptor, where the MyD88 adaptor molecule mediates transduction of the signal. Toll-like 4 receptors bind bacterial lipopolysaccharide (LPS) to initiate an innate immune response."]}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0036506", "l": "De Novo Triacylglycerol Biosynthesis TG(22:0/i-12:0/i-22:0),Metabolic", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0038763", "l": "De Novo Triacylglycerol Biosynthesis TG(a-25:0/10:0/i-24:0),Metabolic", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0055528", "l": "Cardiolipin Biosynthesis CL(i-13:0/a-13:0/i-20:0/i-19:0),Disease", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "REACT:R-SPO-159418", "l": "Recycling of bile acids and salts (Schizosaccharomyces pombe)", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0059317", "l": "Cardiolipin Biosynthesis CL(i-13:0/i-19:0/i-13:0/i-18:0),Disease", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "REACT:R-HSA-205017", "l": "NFG and proNGF binds to p75NTR (Homo sapiens)", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "REACT:R-DDI-69242", "l": "S Phase (Dictyostelium discoideum)", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "REACT:R-GGA-390471", "l": "Association of TriC/CCT with target proteins during biosynthesis (Gallus gallus)", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "REACT:R-MMU-8963889", "l": "Assembly of active LPL and LIPC lipase complexes (Mus musculus)", "d": []}]} {"type": "biolink:Pathway", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0003137", "l": "Notch signaling pathway involved in heart induction", "d": ["The series of molecular signals initiated by binding of an extracellular ligand to a Notch receptor on the surface of the target cell that contributes to heart induction."]}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0045635", "l": "Cardiolipin Biosynthesis CL(a-13:0/i-13:0/a-17:0/a-21:0),Disease", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0049786", "l": "Cardiolipin Biosynthesis CL(i-12:0/a-15:0/a-13:0/a-13:0),Disease", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0043230", "l": "De Novo Triacylglycerol Biosynthesis TG(i-24:0/i-20:0/i-19:0),Metabolic", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "REACT:R-MMU-9634635", "l": "Estrogen-stimulated signaling through PRKCZ (Mus musculus)", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "REACT:R-BTA-3214847", "l": "HATs acetylate histones (Bos taurus)", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0056836", "l": "Cardiolipin Biosynthesis CL(i-13:0/a-25:0/i-21:0/a-25:0),Disease", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0056122", "l": "Cardiolipin Biosynthesis CL(i-13:0/a-17:0/i-17:0/i-20:0),Disease", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0062495", "l": "Cardiolipin Biosynthesis CL(i-14:0/i-14:0/i-17:0/i-12:0),Disease", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0041075", "l": "De Novo Triacylglycerol Biosynthesis TG(i-21:0/8:0/i-13:0),Metabolic", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "REACT:R-MMU-5389840", "l": "Mitochondrial translation elongation (Mus musculus)", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0044335", "l": "Cardiolipin Biosynthesis CL(a-13:0/a-17:0/a-15:0/i-16:0),Disease", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "REACT:R-CFA-8873719", "l": "RAB geranylgeranylation (Canis familiaris)", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0060664", "l": "Cardiolipin Biosynthesis CL(i-13:0/i-24:0/i-15:0/a-13:0),Disease", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "REACT:R-HSA-5637815", "l": "Signaling by Ligand-Responsive EGFR Variants in Cancer (Homo sapiens)", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0061796", "l": "Cardiolipin Biosynthesis CL(i-14:0/i-12:0/i-14:0/a-25:0),Disease", "d": []}]} {"type": "biolink:Pathway", "ic": "85.457082654197222", "identifiers": [{"i": "GO:0002765", "l": "immune response-inhibiting signal transduction", "d": ["The cascade of processes by which a signal interacts with a receptor, causing a change in the level or activity of a second messenger or other downstream target, and ultimately leading to inhibition of an immune response."]}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0046957", "l": "Cardiolipin Biosynthesis CL(a-13:0/i-17:0/a-21:0/i-24:0),Disease", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "REACT:R-RNO-983231", "l": "Factors involved in megakaryocyte development and platelet production (Rattus norvegicus)", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "REACT:R-DRE-8941237", "l": "Invadopodia formation (Danio rerio)", "d": []}]} {"type": "biolink:Pathway", 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Beta-adrenergic receptor-induced cardiac relaxation is achieved by a GPCR-activated adenylate cyclase generating cAMP; cAMP then activates the cAMP-dependent protein kinase A (PKA), which phosphorylates the sarcoplasmic reticulum (SR) membrane protein PLB. In its non-phosphorylated state, PLB acts as an inhibitor of the ATPase Ca(2+) pump of the cardiac SR (SERCA2a); inhibition of the pump is relieved upon phosphorylation. The pump removes Ca(2+) from the cytoplasm, thereby preventing cytosolic Ca(2+)-dependent activation of contractile proteins, leading to enhanced muscle relaxation."]}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0045688", "l": "Cardiolipin Biosynthesis CL(a-13:0/i-13:0/i-12:0/a-17:0),Disease", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "REACT:R-XTR-68884", "l": "Mitotic Telophase/Cytokinesis (Xenopus tropicalis)", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "REACT:R-DME-392499", "l": "Metabolism of proteins (Drosophila melanogaster)", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0054638", "l": "Cardiolipin Biosynthesis CL(i-12:0/i-24:0/a-13:0/a-21:0),Disease", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0000530", "l": "Familial Lipoprotein Lipase Deficiency,Disease", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "REACT:R-SSC-190236", "l": "Signaling by FGFR (Sus scrofa)", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "REACT:R-DRE-111458", "l": "Formation of apoptosome (Danio rerio)", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "REACT:R-SCE-196807", "l": "Nicotinate metabolism (Saccharomyces cerevisiae)", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0038313", "l": "De Novo Triacylglycerol Biosynthesis TG(a-21:0/a-17:0/a-15:0),Metabolic", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "REACT:R-GGA-177929", "l": "Signaling by EGFR (Gallus gallus)", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "REACT:R-RNO-180292", "l": "GAB1 signalosome (Rattus norvegicus)", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0059367", "l": "Cardiolipin Biosynthesis CL(i-13:0/i-19:0/i-16:0/i-14:0),Disease", "d": []}]} {"type": "biolink:Pathway", "identifiers": [{"i": "SMPDB:SMP0036504", "l": "De Novo Triacylglycerol Biosynthesis 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