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Pigment granule biogenesis is poorly understood, as pigment granules are derived from multiple sources including the endoplasmic reticulum, coated vesicles, lysosomes, and endosomes."], "t": []}], "preferred_name": "pigment granule", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C1325637", "l": "cytoplasmic side of endosome membrane", "d": [], "t": []}], "preferred_name": "cytoplasmic side of endosome membrane", "taxa": []} {"type": "biolink:CellularComponent", "ic": "100", "identifiers": [{"i": "GO:0005704", "l": "polytene chromosome band", "d": ["A stretch of densely packed chromatin along the polytene chromosome, visible as a morphologically distinct band."], "t": []}], "preferred_name": "polytene chromosome band", "taxa": []} {"type": "biolink:CellularComponent", "ic": "95.43028691190267", "identifiers": [{"i": "GO:1990706", "l": "MAD1 complex", "d": ["A protein complex involved in the assembly of the mitotic checkpoint complex that in turn inhibits the anaphase promoting complex/cyclosome (APC/C)."], "t": []}], "preferred_name": "MAD1 complex", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C3548372", "l": "icosahedral viral capsid, neck", "d": [], "t": []}], "preferred_name": "icosahedral viral capsid, neck", "taxa": []} {"type": "biolink:CellularComponent", "ic": "89.389454795172327", "identifiers": [{"i": "GO:0110085", "l": "mitotic actomyosin contractile ring", "d": ["A cytoskeletal structure composed of actin filaments, myosin, and myosin-associated proteins that forms beneath the plasma membrane of many cells, including animal cells and yeast cells, in a plane perpendicular to the axis of the mitotic spindle, i.e. the cell division plane. 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Various proteins components of this junction have been identified, but how they are linked to form the ultrastructure of the junction is not known."], "t": []}, {"i": "SNOMEDCT:24206002", "d": [], "t": []}], "preferred_name": "Tight Junctions", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C1325654", "l": "mitochondrial respiratory chain complex I, membrane segment", "d": [], "t": []}], "preferred_name": "mitochondrial respiratory chain complex I, membrane segment", "taxa": []} {"type": "biolink:CellularComponent", "ic": "90.860573823805353", "identifiers": [{"i": "UMLS:C1520191", "l": "Xq22.3", "d": [], "t": []}, {"i": "NCIT:C25144", "l": "Xq22.3", "d": ["A chromosome band present on Xq"], "t": []}], "preferred_name": "Xq22.3", "taxa": []} {"type": "biolink:CellularComponent", "ic": "100", "identifiers": [{"i": "GO:0044158", "l": "host cell wall", "d": ["The rigid or semi-rigid envelope lying outside the host cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. 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In budding yeast, this complex consists of Vps30p, Vps34p, Apg14p and Vps15p."], "t": []}], "preferred_name": "phosphatidylinositol 3-kinase complex, class III, type I", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C2612809", "l": "integrin alpha9-beta1 complex", "d": [], "t": []}], "preferred_name": "integrin alpha9-beta1 complex", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C3821184", "l": "Pmt4p-Pmt4p complex", "d": [], "t": []}], "preferred_name": "Pmt4p-Pmt4p complex", "taxa": []} {"type": "biolink:CellularComponent", "ic": "100", "identifiers": [{"i": "GO:0071130", "l": "alpha5-beta1 integrin-LPP3 complex", "d": ["A protein complex that consists of an alpha5-beta1 integrin complex bound to lipid phosphate phosphohydrolase-3."], "t": []}], "preferred_name": "alpha5-beta1 integrin-LPP3 complex", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C1167026", "l": "lysosomal proton-transporting V-type ATPase complex", "d": [], "t": []}], "preferred_name": "lysosomal proton-transporting V-type ATPase complex", "taxa": []} {"type": "biolink:CellularComponent", "ic": "100", "identifiers": [{"i": "UMLS:C1183337", "l": "Minus end of actin filament", "d": [], "t": []}, {"i": "NCIT:C33130", "l": "Minus End of the Actin Filament", "d": ["The end of an actin filament that is polymerizing at a slower rate."], "t": []}], "preferred_name": "Minus end of actin filament", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C4691107", "l": "pathogen-containing vacuole", "d": [], "t": []}], "preferred_name": "pathogen-containing vacuole", "taxa": []} {"type": "biolink:CellularComponent", "ic": "73.462054205446947", "identifiers": [{"i": "GO:0016469", "l": "proton-transporting two-sector ATPase complex", "d": ["A large protein complex that catalyzes the synthesis or hydrolysis of ATP by a rotational mechanism, coupled to the transport of protons across a membrane. The complex comprises a membrane sector (F0, V0, or A0) that carries out proton transport and a cytoplasmic compartment sector (F1, V1, or A1) that catalyzes ATP synthesis or hydrolysis. Two major types have been characterized: V-type ATPases couple ATP hydrolysis to the transport of protons across a concentration gradient, whereas F-type ATPases, also known as ATP synthases, normally run in the reverse direction to utilize energy from a proton concentration or electrochemical gradient to synthesize ATP. A third type, A-type ATPases have been found in archaea, and are closely related to eukaryotic V-type ATPases but are reversible."], "t": []}], "preferred_name": "proton-transporting two-sector ATPase complex", "taxa": []} {"type": "biolink:CellularComponent", "ic": "100", "identifiers": [{"i": "GO:0005786", "l": "signal recognition particle, endoplasmic reticulum targeting", "d": ["A ribonucleoprotein particle of 325 kDa composed of a 7S (300 nucleotide) RNA molecule and a complex of six different polypeptides. This binds both to the N-terminal signal peptide for proteins destined for the endoplasmic reticulum as they emerge from the large ribosomal subunit and also to the ribosome. This binding arrests further translation thereby preventing the proteins from being released into the cytosol. The SRP-ribosome complex then diffuses to the endoplasmic reticulum where it is bound to the signal recognition particle receptor, which allows resumption of protein synthesis and facilitates the passage of the growing polypeptide chain through the translocon. Through a process involving GTP hydrolysis, the SRP-SRP receptor complex dissociates and SRP returns to the cytosol. Of the six polypeptides of SRP the 54 kDa subunit (SRP54) is the central player. It contains an N-terminal GTPase domain and a C-terminal domain that binds directly to the signal peptide and the SRP RNA. Examples of this component are found in Mus musculus, Saccharomyces cerevisiae and Arabidopsis thaliana."], "t": []}], "preferred_name": "signal recognition particle, endoplasmic reticulum targeting", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C1818870", "l": "negative elongation factor complex location", "d": [], "t": []}], "preferred_name": "negative elongation factor complex location", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C1749482", "l": "80S ribosome", "d": [], "t": []}], "preferred_name": "80S ribosome", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C3157075", "l": "perinuclear endoplasmic reticulum", "d": [], "t": []}], "preferred_name": "perinuclear endoplasmic reticulum", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C3156026", "l": "BAT3 complex", "d": [], "t": []}], "preferred_name": "BAT3 complex", "taxa": []} {"type": "biolink:CellularComponent", "ic": "100", "identifiers": [{"i": "NCIT:C129881", "l": "TRAF1-C5 Locus", "d": ["An intergenic gene locus on the short arm of human chromosome 9 located between the TRAF1 and C5 genes. Polymorphism in this region may be associated with increased susceptibility for rheumatoid arthritis."], "t": []}], "preferred_name": "TRAF1-C5 Locus", "taxa": []} {"type": "biolink:CellularComponent", "ic": "95.43028691190267", "identifiers": [{"i": "UMLS:C1521044", "l": "20p12", "d": [], "t": []}, {"i": "NCIT:C14008", "l": "20p12", "d": ["A chromosome band present on 20p"], "t": []}], "preferred_name": "20p12", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C1166634", "l": "bacterial-type flagellum basal body, distal rod, P ring", "d": [], "t": []}], "preferred_name": "bacterial-type flagellum basal body, distal rod, P ring", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C4235115", "l": "cytoplasmic periphery of the nuclear pore complex", "d": [], "t": []}], "preferred_name": "cytoplasmic periphery of the nuclear pore complex", "taxa": []} {"type": "biolink:CellularComponent", "ic": "86.290860735708023", "identifiers": [{"i": "GO:0060293", "l": "germ plasm", "d": ["Differentiated cytoplasm associated with a pole of an oocyte, egg or early embryo that will be inherited by the cells that will give rise to the germ line."], "t": []}], "preferred_name": "germ plasm", "taxa": []} {"type": "biolink:CellularComponent", "ic": "100", "identifiers": [{"i": "GO:0071821", "l": "FANCM-MHF complex", "d": ["A protein complex contains the proteins FANCM and MHF, or their orthologs, plays an essential role in DNA remodeling, protects replication forks, and is conserved in eukaryotes."], "t": []}], "preferred_name": "FANCM-MHF complex", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C4327130", "l": "actin cytoskeleton-regulatory complex", "d": [], "t": []}], "preferred_name": "actin cytoskeleton-regulatory complex", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C2338262", "l": "Trunk of nerve to left psoas minor", "d": [], "t": []}], "preferred_name": "Trunk of nerve to left psoas minor", "taxa": []} {"type": "biolink:CellularComponent", "ic": "100", "identifiers": [{"i": "GO:0039622", "l": "T=16 icosahedral viral capsid", "d": ["The protein coat that surrounds the infective nucleic acid in some virus particles where the subunits (capsomeres) are arranged to form an icosahedron with T=16 symmetry. The T=16 capsid is composed of 12 pentameric and 150 hexameric capsomeres."], "t": []}], "preferred_name": "T=16 icosahedral viral capsid", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C1166683", "l": "recombination nodule", "d": [], "t": []}], "preferred_name": "recombination nodule", "taxa": []} {"type": "biolink:CellularComponent", "ic": "100", "identifiers": [{"i": "NCIT:C13716", "l": "Internal Ribosome Entry Site", "d": ["Internal ribosome entry site (IRES) is a translational cis-acting element that directs ribosomes to the start codon by a cap-independent mechanism. IRESs are usually about 450 nucleotides in length and were first identified in picornavirus RNAs. IRESs can fold into a stable secondary hairpin structure to be incompatible with efficient translation by ribosomal scanning. (NCI)"], "t": []}], "preferred_name": "Internal Ribosome Entry Site", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C2328027", "l": "Cytoplasm of goblet cell", "d": [], "t": []}], "preferred_name": "Cytoplasm of goblet cell", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C3824405", "l": "bacterial chaperonin ATPase complex", "d": [], "t": []}], "preferred_name": "bacterial chaperonin ATPase complex", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C2753841", "l": "gamma-secretase-Delta1 complex", "d": [], "t": []}], "preferred_name": "gamma-secretase-Delta1 complex", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C5450986", "l": "viral assembly site", "d": [], "t": []}], "preferred_name": "viral assembly site", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C3269017", "l": "interferon regulatory factor complex", "d": [], "t": []}], "preferred_name": "interferon regulatory factor complex", "taxa": []} {"type": "biolink:CellularComponent", "ic": "83.090052188295473", "identifiers": [{"i": "GO:0000803", "l": "sex chromosome", "d": ["A chromosome involved in sex determination."], "t": []}], "preferred_name": "sex chromosome", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C1659559", "l": "nuclear proteasome regulatory particle", "d": [], "t": []}], "preferred_name": "nuclear proteasome regulatory particle", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C4328908", "l": "spine apparatus lumen", "d": [], "t": []}], "preferred_name": "spine apparatus lumen", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C1184882", "l": "Head of internal pillar cell of cochlea", "d": [], "t": []}], "preferred_name": "Head of internal pillar cell of cochlea", "taxa": []} {"type": "biolink:CellularComponent", "ic": "100", "identifiers": [{"i": "GO:0044305", "l": "calyx of Held", "d": ["The terminal specialization of a calyciferous axon which forms large synapses in the mammalian auditory central nervous system."], "t": []}], "preferred_name": "calyx of Held", "taxa": []} {"type": "biolink:CellularComponent", "ic": "90.860573823805353", "identifiers": [{"i": "UMLS:C1520400", "l": "11q23-q24", "d": [], "t": []}, {"i": "NCIT:C24924", "l": "11q23-q24", "d": ["A chromosome band present on 11q"], "t": []}], "preferred_name": "11q23-q24", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C2327594", "l": "Set of raphe nuclei of pontine tegmentum", "d": [], "t": []}], "preferred_name": "Set of raphe nuclei of pontine tegmentum", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C3821044", "l": "cytoplasmic transcriptional repressor complex", "d": [], "t": []}], "preferred_name": "cytoplasmic transcriptional repressor complex", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C2335129", "l": "Cis Golgi cistern", "d": [], "t": []}], "preferred_name": "Cis Golgi cistern", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C1166632", "l": "bacterial-type flagellum basal body, distal rod", "d": [], "t": []}], "preferred_name": "bacterial-type flagellum basal body, distal rod", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C2331170", "l": "Set of cytoplasmic organelles of hyalocyte", "d": [], "t": []}], "preferred_name": "Set of cytoplasmic organelles of hyalocyte", "taxa": []} {"type": "biolink:CellularComponent", "ic": "92.757176116311072", "identifiers": [{"i": "GO:1902937", "l": "inward rectifier potassium channel complex", "d": ["A protein complex which is capable of inward rectifier potassium channel activity."], "t": []}], "preferred_name": "inward rectifier potassium channel complex", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C2263093", "l": "arginine-specific carbamoyl phosphate synthetase complex", "d": [], "t": []}], "preferred_name": "arginine-specific carbamoyl phosphate synthetase complex", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C1167145", "l": "insulin control element activator complex", "d": [], "t": []}], "preferred_name": "insulin control element activator complex", "taxa": []} {"type": "biolink:CellularComponent", "ic": "92.757176116311072", "identifiers": [{"i": "GO:0070701", "l": "mucus layer", "d": ["An extracellular region part that consists of a protective layer of mucus secreted by epithelial cells lining tubular organs of the body such as the colon or secreted into fluids such as saliva. Mucus is a viscous slimy secretion consisting of mucins (i.e. highly glycosylated mucin proteins) and various inorganic salts dissolved in water, with suspended epithelial cells and leukocytes."], "t": []}], "preferred_name": "mucus layer", "taxa": []} {"type": "biolink:CellularComponent", "ic": "100", "identifiers": [{"i": "GO:0140366", "l": "galectin lattice", "d": ["A non-stoichiometric protein complex formed by several galectins crosslinking glycosylated ligands to form a dynamic lattice. The galectin lattice modulates receptor kinase signaling and the functionality of membrane receptors, by regulating the diffusion, compartmentalization and endocytosis of plasma membrane glycoproteins and glycolipids."], "t": []}], "preferred_name": "galectin lattice", "taxa": []} {"type": "biolink:CellularComponent", "ic": "95.43028691190267", "identifiers": [{"i": "GO:0009706", "l": "chloroplast inner membrane", "d": ["The inner, i.e. lumen-facing, lipid bilayer of the chloroplast envelope; also faces the chloroplast stroma."], "t": []}], "preferred_name": "chloroplast inner membrane", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C1167441", "l": "DNA polymerase V complex", "d": [], "t": []}], "preferred_name": "DNA polymerase V complex", "taxa": []} {"type": "biolink:CellularComponent", "ic": "95.43028691190267", "identifiers": [{"i": "UMLS:C1520966", "l": "1p35-p32", "d": [], "t": []}, {"i": "NCIT:C14012", "l": "1p35-p32", "d": ["A chromosome band present on 1p"], "t": []}], "preferred_name": "1p35-p32", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C5137532", "l": "telodendria", "d": [], "t": []}], "preferred_name": "telodendria", "taxa": []} {"type": "biolink:CellularComponent", "ic": "100", "identifiers": [{"i": "GO:0160132", "l": "meisosome", "d": ["A cell part that is composed of multifold plasma membrane of the epidermis where it is in direct contact with apical extracellular matrix. Meisosome, or multiple eisome is named because of its superficial similarity to yeast eisosome."], "t": []}], "preferred_name": "meisosome", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "MESH:D002479", "l": "Inclusion Bodies", "d": [], "t": []}, {"i": "UMLS:C0007637", "l": "Inclusion Bodies", "d": [], "t": []}], "preferred_name": "Inclusion Bodies", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C3893327", "l": "GADD153-C/EBP-alpha complex", "d": [], "t": []}], "preferred_name": "GADD153-C/EBP-alpha complex", "taxa": []} {"type": "biolink:CellularComponent", "ic": "100", "identifiers": [{"i": "GO:0070620", "l": "EGFR-Grb2-Sos complex", "d": ["A protein complex that contains the epidermal growth factor receptor (EGFR), Grb2 and the guanine nucleotide exchange factor Sos (or an ortholog thereof, such as mSos1), and is involved in linking EGFR activation to the p21-Ras pathway."], "t": []}], "preferred_name": "EGFR-Grb2-Sos complex", "taxa": []} {"type": "biolink:CellularComponent", "ic": "100", "identifiers": [{"i": "GO:0042757", "l": "giant axon", "d": ["Extremely large, unmyelinated axon found in invertebrates. 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Composed of a catalytic histone deacetylase subunit, a chromodomain protein, a SIN3 family co-repressor, and a WD repeat protein (Clr6p, Alp13p, Pst2p, and Prw1p respectively in Schizosaccharomyces; Rpd3p, Sin3p, Ume1p, Rco1p and Eaf3 in Saccharomyces; homologs thereof in other species)."], "t": []}], "preferred_name": "Rpd3S complex", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C0598718", "l": "protoplastic membrane", "d": [], "t": []}], "preferred_name": "protoplastic membrane", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C3157097", "l": "CLF-CLC complex", "d": [], "t": []}], "preferred_name": "CLF-CLC complex", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C4235132", "l": "outer mitochondrial membrane protein complex", "d": [], "t": []}], "preferred_name": "outer mitochondrial membrane protein complex", "taxa": []} {"type": "biolink:CellularComponent", "ic": "100", "identifiers": [{"i": "GO:1990906", "l": "accessory outer segment", "d": ["A cilium-like cell projection emanating from the inner segment and running alongside the outer segment of photoreceptors."], "t": []}], "preferred_name": "accessory outer segment", "taxa": []} {"type": "biolink:CellularComponent", "ic": "100", "identifiers": [{"i": "GO:0032426", "l": "stereocilium tip", "d": ["A distinct compartment at the tip of a stereocilium, distal to the site of attachment to the apical cell surface. It consists of a dense matrix bridging the barbed ends of the stereocilium actin filaments with the overlying plasma membrane, is dynamic compared to the shaft, and is required for stereocilium elongation."], "t": []}], "preferred_name": "stereocilium tip", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C3820749", "l": "viroplasm viral factory", "d": [], "t": []}], "preferred_name": "viroplasm viral factory", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C3896481", "l": "mitochondrial inner membrane assembly complex", "d": [], "t": []}], "preferred_name": "mitochondrial inner membrane assembly complex", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C3896471", "l": "PCSK9-AnxA2 complex", "d": [], "t": []}], "preferred_name": "PCSK9-AnxA2 complex", "taxa": []} {"type": "biolink:CellularComponent", "ic": "100", "identifiers": [{"i": "GO:0140225", "l": "DNA topoisomerase III-beta-TDRD3 complex", "d": ["A protein complex that has DNA topoisomerase type I and RNA topoisomerase activities."], "t": []}], "preferred_name": "DNA topoisomerase III-beta-TDRD3 complex", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C1166824", "l": "hemoglobin complex", "d": [], "t": []}], "preferred_name": "hemoglobin complex", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C0225330", "l": "Intracellular fibril", "d": [], "t": []}, {"i": "SNOMEDCT:83098003", "d": [], "t": []}], "preferred_name": "Intracellular fibril", "taxa": []} {"type": "biolink:CellularComponent", "ic": "95.43028691190267", "identifiers": [{"i": "GO:0097516", "l": "microvillar actin bundle", "d": ["A parallel bundle of actin filaments at the core of a microvillus."], "t": []}], "preferred_name": "microvillar actin bundle", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C2263052", "l": "Mis12 complex", "d": [], "t": []}], "preferred_name": "Mis12 complex", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C3824512", "l": "Bre1-Rad6 ubiquitin ligase complex", "d": [], "t": []}], "preferred_name": "Bre1-Rad6 ubiquitin ligase complex", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C1523559", "l": "BLOC-3 complex", "d": [], "t": []}], "preferred_name": "BLOC-3 complex", "taxa": []} {"type": "biolink:CellularComponent", "ic": "95.43028691190267", "identifiers": [{"i": "GO:0070693", "l": "P-TEFb-cap methyltransferase complex", "d": ["A protein complex that is formed by the association of positive transcription elongation factor complex b (P-TEFb) with the mRNA capping methyltransferase."], "t": []}], "preferred_name": "P-TEFb-cap methyltransferase complex", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C3821355", "l": "cell adhesion complex", "d": [], "t": []}], "preferred_name": "cell adhesion complex", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C1167087", "l": "chromatin remodeling complex location", "d": [], "t": []}], "preferred_name": "chromatin remodeling complex location", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C4690691", "l": "synapsis initiation complex", "d": [], "t": []}], "preferred_name": "synapsis initiation complex", "taxa": []} {"type": "biolink:CellularComponent", "ic": "90.860573823805353", "identifiers": [{"i": "UMLS:C1520390", "l": "11q14", "d": [], "t": []}, {"i": "NCIT:C13836", "l": "11q14", "d": ["A chromosome band present on 11q"], "t": []}], "preferred_name": "11q14", "taxa": []} {"type": "biolink:CellularComponent", "ic": "100", "identifiers": [{"i": "GO:0055087", "l": "Ski complex", "d": ["A protein complex that regulates RNA degradation by the exosome complex. In Saccharomyces the complex has a heterotetrameric stoichiometry consisting of one copy each of Ski2p and Ski3 and two copies of Ski8p."], "t": []}], "preferred_name": "Ski complex", "taxa": []} {"type": "biolink:CellularComponent", "ic": "100", "identifiers": [{"i": "GO:0034469", "l": "Golgi stack lumen", "d": ["The volume enclosed by any of the membranes of the thin, flattened cisternae that form the central portion of the Golgi complex."], "t": []}], "preferred_name": "Golgi stack lumen", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C2336634", "l": "Cytoplasm of neuroglial cell", "d": [], "t": []}], "preferred_name": "Cytoplasm of neuroglial cell", "taxa": []} {"type": "biolink:CellularComponent", "ic": "100", "identifiers": [{"i": "GO:1990696", "l": "USH2 complex", "d": ["A protein complex composed of four proteins, loss of which results in Usher Syndrome type 2 (USH2 syndrome), a leading genetic cause of combined hearing and vision loss. This complex is conserved in many species; in mice, it is composed of USH2A, GPR98 (aka ADGRV1), WHRN, and PDZD7."], "t": []}], "preferred_name": "USH2 complex", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C4691125", "l": "apical distal dendrite", "d": [], "t": []}], "preferred_name": "apical distal dendrite", "taxa": []} {"type": "biolink:CellularComponent", "ic": "100", "identifiers": [{"i": "GO:0044569", "l": "[Ni-Fe] hydrogenase complex", "d": ["A microbial enzyme complex which contains nickel and iron in its active site. In Acetomicrobium flavidum it is an alpha 2 beta 2 tetramer."], "t": []}], "preferred_name": "[Ni-Fe] hydrogenase complex", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C1820217", "l": "presynaptic active zone membrane", "d": [], "t": []}], "preferred_name": "presynaptic active zone membrane", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C1624054", "l": "tRNA methyltransferase complex", "d": [], "t": []}], "preferred_name": "tRNA methyltransferase complex", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C3549240", "l": "eisosome filament", "d": [], "t": []}], "preferred_name": "eisosome filament", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C0230602", "l": "Cell membrane, apical aspect of polarized cell", "d": [], "t": []}, {"i": "SNOMEDCT:51374002", "d": [], "t": []}], "preferred_name": "Cell membrane, apical aspect of polarized cell", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C4690294", "l": "potassium/sodium hyperpolarization-activated channel 3 complex", "d": [], "t": []}], "preferred_name": "potassium/sodium hyperpolarization-activated channel 3 complex", "taxa": []} {"type": "biolink:CellularComponent", "ic": "95.43028691190267", "identifiers": [{"i": "GO:0043626", "l": "PCNA complex", "d": ["A protein complex composed of three identical PCNA monomers, each comprising two similar domains, which are joined in a head-to-tail arrangement to form a homotrimer. Forms a ring-like structure in solution, with a central hole sufficiently large to accommodate the double helix of DNA. Originally characterized as a DNA sliding clamp for replicative DNA polymerases and as an essential component of the replisome, and has also been shown to be involved in other processes including Okazaki fragment processing, DNA repair, translesion DNA synthesis, DNA methylation, chromatin remodeling and cell cycle regulation."], "t": []}], "preferred_name": "PCNA complex", "taxa": []} {"type": "biolink:CellularComponent", "ic": "92.757176116311072", "identifiers": [{"i": "GO:0160110", "l": "axonemal microtubule doublet inner sheath", "d": ["A structural network of microtubule inner proteins (MIPs) located inside the lumens of the A and B tubules of the axonemal microtuble doublet that helps stabilize the doublet microtubule."], "t": []}], "preferred_name": "axonemal microtubule doublet inner sheath", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C4318928", "l": "T-bar", "d": [], "t": []}], "preferred_name": "T-bar", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C3549084", "l": "T=3 icosahedral viral capsid", "d": [], "t": []}], "preferred_name": "T=3 icosahedral viral capsid", "taxa": []} {"type": "biolink:CellularComponent", "ic": "100", "identifiers": [{"i": "GO:0016029", "l": "subrhabdomeral cisterna", "d": ["A membrane-bounded compartment that is found at the base of the rhabdomere and contains stored calcium, InsP3 receptors and smooth endoplasmic reticulum Ca2+-ATPase."], "t": []}], "preferred_name": "subrhabdomeral cisterna", "taxa": []} {"type": "biolink:CellularComponent", "ic": "53.636001082296623", "identifiers": [{"i": "GO:1902494", "l": "catalytic complex", "d": ["A protein complex which is capable of catalytic activity."], "t": []}], "preferred_name": "catalytic complex", "taxa": []} {"type": "biolink:CellularComponent", "ic": "75.051963878740779", "identifiers": [{"i": "GO:0097525", "l": "spliceosomal snRNP complex", "d": ["A small ribonucleoprotein complex involved in formation of the spliceosome."], "t": []}], "preferred_name": "spliceosomal snRNP complex", "taxa": []} {"type": "biolink:CellularComponent", "ic": "86.290860735708023", "identifiers": [{"i": "GO:0099243", "l": "extrinsic component of synaptic membrane", "d": ["The component of the synaptic membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region."], "t": []}], "preferred_name": "extrinsic component of synaptic membrane", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C2612889", "l": "transcription factor TFIIIC2 complex", "d": [], "t": []}], "preferred_name": "transcription factor TFIIIC2 complex", "taxa": []} {"type": "biolink:CellularComponent", "ic": "100", "identifiers": [{"i": "GO:0097654", "l": "platelet SNARE complex", "d": ["A SNARE complex that is capable of fusing intracellular vesicles to the plasma membrane of platelets for exocytosis of alpha-granules or dense granules. Contains isoforms of VAMP, SNAP and syntaxin proteins. Ternary SNARE complexes interact in a circular array to form ring complexes or channels around the membrane fusion. A common composition in human is VAMP-8, SNAP-23 and syntaxin-2 or -4."], "t": []}], "preferred_name": "platelet SNARE complex", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C1179929", "l": "Wall of rough endoplasmic reticulum cistern", "d": [], "t": []}], "preferred_name": "Wall of rough endoplasmic reticulum cistern", "taxa": []} {"type": "biolink:CellularComponent", "ic": "100", "identifiers": [{"i": "GO:1990191", "l": "cobalamin transport complex", "d": ["Protein complex facilitating ATP-dependent cobalamin (vitamin B12) transport through inner cell membrane (periplasm to cytoplasm) in Gram-negative bacteria. In E. coli the system is composed of a periplasmic cobalamin-binding protein (BtuF), an integral membrane homodimer, BtuC, and a cytoplasmic ATP-binding homodimer BtuD."], "t": []}], "preferred_name": "cobalamin transport complex", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C1258077", "l": "Subnuclear Space", "d": [], "t": []}], "preferred_name": "Subnuclear Space", "taxa": []} {"type": "biolink:CellularComponent", "ic": "100", "identifiers": [{"i": "GO:0060203", "l": "clathrin-sculpted glutamate transport vesicle membrane", "d": ["The lipid bilayer surrounding a clathrin-sculpted glutamate transport vesicle."], "t": []}], "preferred_name": "clathrin-sculpted glutamate transport vesicle membrane", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C1523437", "l": "glutamyl-tRNA(Gln) amidotransferase complex location", "d": [], "t": []}], "preferred_name": "glutamyl-tRNA(Gln) amidotransferase complex location", "taxa": []} {"type": "biolink:CellularComponent", "ic": "85.51435223262213", "identifiers": [{"i": "GO:0030998", "l": "linear element", "d": ["A proteinaceous scaffold associated with fission yeast chromosomes during meiotic prophase. Linear elements consist of a protein complex, LinE, with four main structural components (Rec10, Rec25, Rec27, and Mug20 in S. pombe) associated with chromatin. The resulting structure is related to but not equivalent to the synaptonemal complex."], "t": []}], "preferred_name": "linear element", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C2253855", "l": "perinuclear region of cytoplasm", "d": [], "t": []}], "preferred_name": "perinuclear region of cytoplasm", "taxa": []} {"type": "biolink:CellularComponent", "ic": "72.581721471416046", "identifiers": [{"i": "GO:0044423", "l": "virion component", "d": ["Any constituent part of a virion, a complete fully infectious extracellular virus particle."], "t": []}], "preferred_name": "virion component", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C1623307", "l": "membrane-enclosed lumen", "d": [], "t": []}], "preferred_name": "membrane-enclosed lumen", "taxa": []} {"type": "biolink:CellularComponent", "ic": "95.43028691190267", "identifiers": [{"i": "GO:0030143", "l": "COPI-coated inter-Golgi transport vesicle", "d": ["A vesicle that mediates transport of cargo within the Golgi complex (for example, between cisternae of the Golgi stack)."], "t": []}], "preferred_name": "COPI-coated inter-Golgi transport vesicle", "taxa": []} {"type": "biolink:CellularComponent", "ic": "100", "identifiers": [{"i": "GO:0017023", "l": "myosin phosphatase complex", "d": ["An enzyme complex that catalyzes the removal of the phosphate group from phosphomyosin. Composed of a PP1 catalytic subunit (PP1c/PPP1CB) and a myosin phosphatase targeting subunit (MYPT1/PPP1R12A)."], "t": []}], "preferred_name": "myosin phosphatase complex", "taxa": []} {"type": "biolink:CellularComponent", "ic": "100", "identifiers": [{"i": "GO:0120201", "l": "cone photoreceptor disc membrane", "d": ["Stack of disc membranes located inside a cone photoreceptor outer segment, and containing densely packed molecules of opsin photoreceptor proteins that traverse the lipid bilayer. Cone disc membranes arise as evaginations of the ciliary membrane during the development of the cone outer segment and remain contiguous with the ciliary membrane."], "t": []}], "preferred_name": "cone photoreceptor disc membrane", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C1184870", "l": "Stereocilium of type 1 vestibular sensory cell", "d": [], "t": []}], "preferred_name": "Stereocilium of type 1 vestibular sensory cell", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C2923576", "l": "Hemoglobin H inclusion bodies", "d": [], "t": []}], "preferred_name": "Hemoglobin H inclusion bodies", "taxa": []} {"type": "biolink:CellularComponent", "ic": "100", "identifiers": [{"i": "GO:1990040", "l": "sub-surface cisterna", "d": ["Specialization of the hypolemmal cisterna consisting of either single profiles or closely apposed stacks of endoplasmic reticulum in which the lumen is obliterated, lying 10-20 nm beneath the plasma membrane."], "t": []}], "preferred_name": "sub-surface cisterna", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C1167439", "l": "dimethyl sulfoxide reductase complex", "d": [], "t": []}], "preferred_name": "dimethyl sulfoxide reductase complex", "taxa": []} {"type": "biolink:CellularComponent", "ic": "89.389454795172327", "identifiers": [{"i": "GO:0031519", "l": "PcG protein complex", "d": ["A chromatin-associated multiprotein complex containing Polycomb Group proteins. In Drosophila, Polycomb group proteins are involved in the long-term maintenance of gene repression, and PcG protein complexes associate with Polycomb group response elements (PREs) in target genes to regulate higher-order chromatin structure."], "t": []}], "preferred_name": "PcG protein complex", "taxa": []} {"type": "biolink:CellularComponent", "ic": "88.187463028213742", "identifiers": [{"i": "GO:0042383", "l": "sarcolemma", "d": ["The outer membrane of a muscle cell, consisting of the plasma membrane, a covering basement membrane (about 100 nm thick and sometimes common to more than one fiber), and the associated loose network of collagen fibers."], "t": []}], "preferred_name": "sarcolemma", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C1167000", "l": "plastid small ribosomal subunit", "d": [], "t": []}], "preferred_name": "plastid small ribosomal subunit", "taxa": []} {"type": "biolink:CellularComponent", "ic": "85.51435223262213", "identifiers": [{"i": "UMLS:C1520790", "l": "17q25.1", "d": [], "t": []}, {"i": "NCIT:C24979", "l": "17q25.1", "d": ["A chromosome band present on 17q"], "t": []}], "preferred_name": "17q25.1", "taxa": []} {"type": "biolink:CellularComponent", "ic": "95.43028691190267", "identifiers": [{"i": "GO:0039662", "l": "host cell outer membrane", "d": ["A lipid bilayer that forms the outermost layer of the cell envelope, occurring in a host cell."], "t": []}], "preferred_name": "host cell outer membrane", "taxa": []} {"type": "biolink:CellularComponent", "ic": "100", "identifiers": [{"i": "GO:0140091", "l": "mBAF complex", "d": ["A muscle cell-specific SWI/SNF-type complex that contains eight to fourteen proteins, including both conserved (core) and nonconserved components; contains the ATPase product of either the SMARCA4/BAF190A/BRG1 gene, the mammalian ortholog of the yeast SNF2 gene, or the SMARCA2/BAF190B/BRM gene, the mammalian ortholog of the Drosophila brm (brahma) gene, or an ortholog of either of these genes, and the muscle-specific product of the DPF3/BAF45C gene or an ortholog thereof."], "t": []}], "preferred_name": "mBAF complex", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C3549061", "l": "viral inner membrane", "d": [], "t": []}], "preferred_name": "viral inner membrane", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C3157061", "l": "MPP7-DLG1-LIN7 complex", "d": [], "t": []}], "preferred_name": "MPP7-DLG1-LIN7 complex", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C1180043", "l": "Lipid bilayer of wall of rough endoplasmic reticulum cistern", "d": [], "t": []}], "preferred_name": "Lipid bilayer of wall of rough endoplasmic reticulum cistern", "taxa": []} {"type": "biolink:CellularComponent", "ic": "100", "identifiers": [{"i": "GO:0097203", "l": "phagocytic cup lip", "d": ["The tip or margin of the progressing circular lamella that engulfs a particle during phagocytosis. 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The complex functions primarily as an activating receptor for IgG."], "t": []}], "preferred_name": "Fc-gamma receptor III complex", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C2752488", "l": "nucleoplasmic reticulum", "d": [], "t": []}], "preferred_name": "nucleoplasmic reticulum", "taxa": []} {"type": "biolink:CellularComponent", "ic": "100", "identifiers": [{"i": "GO:0030089", "l": "phycobilisome", "d": ["Any of the granules, approximately 32 nm x 48 nm and consisting of highly aggregated phycobiliproteins, that are attached in arrays to the external face of a thylakoid membrane in algae of the phyla Cyanophyta and Rhodophyta, where they function as light-harvesting devices in photosynthesis. 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This type of septin structure is observed at the bud neck of budding fungal cells, at the site of cell division in animal cells, at the junction between the mother cell and a pseudohyphal projection, and also within hyphae of filamentous fungi at sites where a septum will form."], "t": []}], "preferred_name": "septin ring", "taxa": []} {"type": "biolink:CellularComponent", "ic": "92.757176116311072", "identifiers": [{"i": "GO:0035354", "l": "Toll-like receptor 1-Toll-like receptor 2 protein complex", "d": ["A heterodimeric protein complex containing Toll-like receptor 1 (TLR1) and Toll-like receptor 2 (TLR2)."], "t": []}], "preferred_name": "Toll-like receptor 1-Toll-like receptor 2 protein complex", "taxa": []} {"type": "biolink:CellularComponent", "ic": "100", "identifiers": [{"i": "GO:0036024", "l": "protein C inhibitor-TMPRSS7 complex", "d": ["A heterodimeric protein complex that contains protein C inhibitor (SERPINA5) and transmembrane protease serine 7 (TMPRSS7); formation of the complex inhibits the serine protease activity of transmembrane protease serine 7."], "t": []}], "preferred_name": "protein C inhibitor-TMPRSS7 complex", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C3158845", "l": "Mon1-Ccz1 complex", "d": [], "t": []}], "preferred_name": "Mon1-Ccz1 complex", "taxa": []} {"type": "biolink:CellularComponent", "ic": "100", "identifiers": [{"i": "GO:0032587", "l": "ruffle membrane", "d": ["The portion of the plasma membrane surrounding a ruffle."], "t": []}], "preferred_name": "ruffle membrane", "taxa": []} {"type": "biolink:CellularComponent", "ic": "82.601480381641593", "identifiers": [{"i": "UMLS:C1520868", "l": "19q13.42", "d": [], "t": []}, {"i": "NCIT:C24988", "l": "19q13.42", "d": ["A chromosome band present on 19q"], "t": []}], "preferred_name": "19q13.42", "taxa": []} {"type": "biolink:CellularComponent", "ic": "100", "identifiers": [{"i": "GO:0032517", "l": "SOD1-calcineurin complex", "d": ["A protein complex formed by the association of superoxide dismutase 1 (SOD1) with calcineurin; 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the functional ribosome is at the AUG, with the methionyl/formyl-methionyl-tRNA positioned at the P site."], "t": []}], "preferred_name": "translation initiation complex", "taxa": []} {"type": "biolink:CellularComponent", "ic": "100", "identifiers": [{"i": "GO:1902693", "l": "superoxide dismutase complex", "d": ["A protein complex which is capable of superoxide dismutase activity."], "t": []}], "preferred_name": "superoxide dismutase complex", "taxa": []} {"type": "biolink:CellularComponent", "ic": "100", "identifiers": [{"i": "GO:0000802", "l": "transverse filament", "d": ["A structural unit of the synaptonemal complex that spans the regions between the lateral elements and connects them."], "t": []}], "preferred_name": "transverse filament", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C5380153", "l": "5-hydroxyisourate hydrolase complex", "d": [], "t": []}], "preferred_name": "5-hydroxyisourate hydrolase complex", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C0230805", "l": "Annulate lamella, diaphragm of fenestration", "d": [], "t": []}, {"i": "SNOMEDCT:33438005", "d": [], "t": []}], "preferred_name": "Annulate lamella, diaphragm of fenestration", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C3544405", "l": "tail portion", "d": [], "t": []}], "preferred_name": "tail portion", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C1523865", "l": "membrane-bounded organelle", "d": [], "t": []}], "preferred_name": "membrane-bounded organelle", "taxa": []} {"type": "biolink:CellularComponent", "ic": "100", "identifiers": [{"i": "GO:0045276", "l": "plasma membrane respiratory chain complex III", "d": ["A part of the respiratory chain located in the plasma membrane, containing about 10 polypeptide subunits including four redox centers: cytochrome b/b6, cytochrome c1 and an 2Fe-2S cluster. Catalyzes the oxidation of ubiquinol by oxidized cytochrome c1. Examples of this component are found in bacterial species."], "t": []}], "preferred_name": "plasma membrane respiratory chain complex III", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C1167427", "l": "CAAX-protein geranylgeranyltransferase complex", "d": [], "t": []}], "preferred_name": "CAAX-protein geranylgeranyltransferase complex", "taxa": []} {"type": "biolink:CellularComponent", "ic": "85.51435223262213", "identifiers": [{"i": "UMLS:C1521499", "l": "5q35", "d": [], "t": []}, {"i": "NCIT:C13952", "l": "5q35", "d": ["A chromosome band present on 5q"], "t": []}], "preferred_name": "5q35", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C1183512", "l": "Intermembranous matrix proper of mitochondrion", "d": [], "t": []}], "preferred_name": "Intermembranous matrix proper of mitochondrion", "taxa": []} {"type": "biolink:CellularComponent", "ic": "75.051963878740779", "identifiers": [{"i": "MESH:D007382", "l": "Intermediate Filaments", "d": [], "t": []}, {"i": "UMLS:C0021770", "l": "Intermediate Filaments", "d": [], "t": []}, {"i": "NCIT:C13248", "l": "Intermediate Filament", "d": ["A class of tough protein filaments (including keratin filaments, neurofilaments, desmin, and vimentin) that measure 8-10 nm in thickness and comprise part of the cytoskeleton of the cytoplasm of most eukaryotic cells; so named because they are intermediate in thickness between actin filaments and microtubules."], "t": []}], "preferred_name": "Intermediate Filaments", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C1623194", "l": "cytosolic proteasome core complex, beta-subunit complex", "d": [], "t": []}], "preferred_name": "cytosolic proteasome core complex, beta-subunit complex", "taxa": []} {"type": "biolink:CellularComponent", "ic": "92.757176116311072", "identifiers": [{"i": "UMLS:C2825981", "l": "9q33.3", "d": [], "t": []}, {"i": "NCIT:C82131", "l": "9q33.3", "d": ["A chromosome band present on 9q."], "t": []}], "preferred_name": "9q33.3", "taxa": []} {"type": "biolink:CellularComponent", "ic": "100", "identifiers": [{"i": "GO:0090653", "l": "apical recycling endosome", "d": ["Tubulo-vesicular structure located in the apical cytoplasm that participates in apical cargo recycling in polarized epithelial cells."], "t": []}], "preferred_name": "apical recycling endosome", "taxa": []} {"type": "biolink:CellularComponent", "ic": "71.028704465244275", "identifiers": [{"i": "UMLS:C0205708", "l": "Cytoplasmic inclusion (cell structure)", "d": [], "t": []}, {"i": "NCIT:C32423", "l": "Cytoplasmic Inclusion", "d": ["A stainable aggregation of protein, lipid or small molecules in the cytoplasm."], "t": []}, {"i": "SNOMEDCT:29015002", "d": [], "t": []}], "preferred_name": "Cytoplasmic inclusion (cell structure)", "taxa": []} {"type": "biolink:CellularComponent", "ic": "100", "identifiers": [{"i": "GO:0120307", "l": "Hechtian strand", "d": ["An extended membranous thread which firmly connects the plasma membrane to the cell wall during plasmolysis such that the plasma membrane does not separate from the cell wall completely."], "t": []}], "preferred_name": "Hechtian strand", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C2244322", "l": "eukaryotic ribosomal SSU", "d": [], "t": []}], "preferred_name": "eukaryotic ribosomal SSU", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C1180349", "l": "Nucleus of muscle cell", "d": [], "t": []}], "preferred_name": "Nucleus of muscle cell", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C3824404", "l": "GroEL-GroES complex", "d": [], "t": []}], "preferred_name": "GroEL-GroES complex", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C0230622", "l": "Synaptic membrane specialization, presynaptic", "d": [], "t": []}, {"i": "SNOMEDCT:24843005", "d": [], "t": []}], "preferred_name": "Synaptic membrane specialization, presynaptic", "taxa": []} {"type": "biolink:CellularComponent", "ic": "100", "identifiers": [{"i": "GO:0097585", "l": "dolichyl-phosphate-mannose-protein mannosyltransferase Pmt5p-Pmt3p dimer complex", "d": ["A protein dimer complex that possesses dolichyl-phosphate-mannose-protein mannosyltransferase activity and, in S. cerevisiae, is composed of Pmt5p-Pmt3p."], "t": []}], "preferred_name": "dolichyl-phosphate-mannose-protein mannosyltransferase Pmt5p-Pmt3p dimer complex", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C1167229", "l": "interleukin-12 receptor complex", "d": [], "t": []}], "preferred_name": "interleukin-12 receptor complex", "taxa": []} {"type": "biolink:CellularComponent", "ic": "100", "identifiers": [{"i": "GO:0090641", "l": "microsporidian-type endospore", "d": ["The middle layer in a microsporidian spore wall that lies under the exospore and outside the plasma membrane, containing chitin and proteins."], "t": []}], "preferred_name": "microsporidian-type endospore", "taxa": []} {"type": "biolink:CellularComponent", "ic": "95.43028691190267", "identifiers": [{"i": "GO:0044178", "l": "host cell Golgi membrane", "d": ["The lipid bilayer surrounding any of the compartments of the host cell Golgi apparatus."], "t": []}], "preferred_name": "host cell Golgi membrane", "taxa": []} {"type": "biolink:CellularComponent", "ic": "95.43028691190267", "identifiers": [{"i": "GO:0031040", "l": "micronucleus", "d": ["A membrane-bounded organelle of ciliated protozoan cells that contains a diploid copy of the cell's complete genome. Sections of contiguous sequence in the macronucleus are often interrupted by internal eliminated sequences (IES), and may be permuted, in micronuclei. Genic transcription is not found in micronuclei. Some ciliate species may contain multiple micronuclei per cell."], "t": []}], "preferred_name": "micronucleus", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "MESH:D000088482", "l": "Dense Core Vesicles", "d": [], "t": []}, {"i": "UMLS:C0887944", "l": "Dense Core Vesicles", "d": [], "t": []}], "preferred_name": "Dense Core Vesicles", "taxa": []} {"type": "biolink:CellularComponent", "ic": "75.051963878740779", "identifiers": [{"i": "MESH:D009685", "l": "Nuclear Envelope", "d": [], "t": []}, {"i": "UMLS:C0028584", "l": "Nuclear Envelope", "d": [], "t": []}, {"i": "NCIT:C13265", "l": "Nuclear Membrane", "d": ["The double-layer membrane structure enclosing the nucleus in eukaryotic cells. It separates the DNA of the cell from the cytosol. For exchange of material, for example, proteins and mRNA, it is punctured with numerous nuclear pores."], "t": []}, {"i": "SNOMEDCT:49842008", "d": [], "t": []}], "preferred_name": "Nuclear Envelope", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C2246686", "l": "transcription factor TFTC complex", "d": [], "t": []}], "preferred_name": "transcription factor TFTC complex", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C3893265", "l": "NF-Y transcription factor complex", "d": [], "t": []}], "preferred_name": "NF-Y transcription factor complex", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C2244324", "l": "chloroplast small ribosomal subunit", "d": [], "t": []}], "preferred_name": "chloroplast small ribosomal subunit", "taxa": []} {"type": "biolink:CellularComponent", "ic": "95.43028691190267", "identifiers": [{"i": "GO:0034098", "l": "VCP-NPL4-UFD1 AAA ATPase complex", "d": ["A multiprotein ATPase complex required for the efficient dislocation of ER-lumenal degradation substrates, and their subsequent proteolysis by the proteasome. In budding yeast, this complex includes Cdc48p, Npl4p and Ufd1p proteins. In mammals, this complex includes a hexamer of VCP/p97 (a cytosolic ATPase) and trimers of each of its cofactors UFD1L and NPL4 (NPLOC4) (e.g. a 6:3:3 stoichiometry)."], "t": []}], "preferred_name": "VCP-NPL4-UFD1 AAA ATPase complex", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C4328940", "l": "parallel fiber to Purkinje cell synapse", "d": [], "t": []}], "preferred_name": "parallel fiber to Purkinje cell synapse", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C1622559", "l": "uropod membrane", "d": [], "t": []}], "preferred_name": "uropod membrane", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C1167137", "l": "ATAC complex", "d": [], "t": []}], "preferred_name": "ATAC complex", "taxa": []} {"type": "biolink:CellularComponent", "ic": "100", "identifiers": [{"i": "GO:0036014", "l": "cyanelle intermembrane space", "d": ["The region between the inner and outer lipid bilayers of the cyanelle envelope; includes the peptidoglycan layer."], "t": []}], "preferred_name": "cyanelle intermembrane space", "taxa": []} {"type": "biolink:CellularComponent", "ic": "92.757176116311072", "identifiers": [{"i": "GO:0031105", "l": "septin complex", "d": ["A protein complex containing septins. Typically, these complexes contain multiple septins and are oligomeric."], "t": []}], "preferred_name": "septin complex", "taxa": []} {"type": "biolink:CellularComponent", "ic": "100", "identifiers": [{"i": "GO:1990528", "l": "Rvs161p-Rvs167p complex", "d": ["A protein complex that is involved in endocytosis in the yeast S. cerevisiae."], "t": []}], "preferred_name": "Rvs161p-Rvs167p complex", "taxa": []} {"type": "biolink:CellularComponent", "ic": "100", "identifiers": [{"i": "GO:0070912", "l": "Ddb1-Ckn1 complex", "d": ["A heterodimeric nucleotide-excision repair complex that is involved in transcription-coupled repair. The subunits are known as Ddb1 and Ckn1 in S. pombe; Ddb1 contains a motif called the DDB-box that interacts with adaptor proteins for DDB1/cullin 4 ubiquitin ligases."], "t": []}], "preferred_name": "Ddb1-Ckn1 complex", "taxa": []} {"type": "biolink:CellularComponent", "ic": "78.031767293544277", "identifiers": [{"i": "GO:0120111", "l": "neuron projection cytoplasm", "d": ["All of the contents of a plasma membrane bounded neuron projection, excluding the plasma membrane surrounding the projection."], "t": []}], "preferred_name": "neuron projection cytoplasm", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C2611172", "l": "Ku-DNA ligase complex", "d": [], "t": []}], "preferred_name": "Ku-DNA ligase complex", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C3821199", "l": "ventral disc dorsal microribbon", "d": [], "t": []}], "preferred_name": "ventral disc dorsal microribbon", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C3821138", "l": "axonemal central pair", "d": [], "t": []}], "preferred_name": "axonemal central pair", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C5137533", "l": "cone telodendria", "d": [], "t": []}], "preferred_name": "cone telodendria", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C3546536", "l": "sulfopyruvate decarboxylase complex", "d": [], "t": []}], "preferred_name": "sulfopyruvate decarboxylase complex", "taxa": []} {"type": "biolink:CellularComponent", "ic": "100", "identifiers": [{"i": "GO:0097546", "l": "ciliary base", "d": ["Area of the cilium (also called flagellum) where the basal body and the axoneme are anchored to the plasma membrane. The ciliary base encompasses the distal part of the basal body, transition fibers and transition zone and is structurally and functionally very distinct from the rest of the cilium. In this area proteins are sorted and filtered before entering the cilium, and many ciliary proteins localize specifically to this area."], "t": []}], "preferred_name": "ciliary base", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C3549076", "l": "viral inner capsid", "d": [], "t": []}], "preferred_name": "viral inner capsid", "taxa": []} {"type": "biolink:CellularComponent", "ic": "88.187463028213742", "identifiers": [{"i": "UMLS:C1521502", "l": "5q35.2", "d": [], "t": []}, {"i": "NCIT:C25088", "l": "5q35.2", "d": ["A chromosome band present on 5q"], "t": []}], "preferred_name": "5q35.2", "taxa": []} {"type": "biolink:CellularComponent", "ic": "100", "identifiers": [{"i": "GO:0031387", "l": "MPF complex", "d": ["A complex consisting of a Cdc2-class (also known as Cdc28) cyclin-dependent kinase and an M-phase cyclin such as S. pombe Cdc13. The MPF complex phosphorylates and activates the anaphase promoting complex (APC)."], "t": []}], "preferred_name": "MPF complex", "taxa": []} {"type": "biolink:CellularComponent", "ic": "95.43028691190267", "identifiers": [{"i": "UMLS:C1520476", "l": "12p13-p12.3", "d": [], "t": []}, {"i": "NCIT:C24928", "l": "12p13-p12.3", "d": ["A chromosome band present on 12p"], "t": []}], "preferred_name": "12p13-p12.3", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "MESH:D020130", "l": "Bacterial Chromatophores", "d": [], "t": []}, {"i": "UMLS:C0600496", "l": "Bacterial chromatophore", "d": [], "t": []}], "preferred_name": "Bacterial Chromatophores", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C3824332", "l": "IHF-DNA complex", "d": [], "t": []}], "preferred_name": "IHF-DNA complex", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C3821159", "l": "left lateral basal body pair", "d": [], "t": []}], "preferred_name": "left lateral basal body pair", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C3821268", "l": "lumenal side of Golgi membrane", "d": [], "t": []}], "preferred_name": "lumenal side of Golgi membrane", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C4326889", "l": "Q-MT bundle", "d": [], "t": []}], "preferred_name": "Q-MT bundle", "taxa": []} {"type": "biolink:CellularComponent", "ic": "79.621676966838109", "identifiers": [{"i": "UMLS:C1515532", "l": "9q34.3", "d": [], "t": []}, {"i": "NCIT:C13828", "l": "9q34.3", "d": ["A chromosome band present on 9q"], "t": []}], "preferred_name": "9q34.3", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C3546222", "l": "viral tail", "d": [], "t": []}], "preferred_name": "viral tail", "taxa": []} {"type": "biolink:CellularComponent", "ic": "100", "identifiers": [{"i": "GO:0097130", "l": "cyclin D3-CDK4 complex", "d": ["A protein complex consisting of cyclin D3 and cyclin-dependent kinase 4 (CDK4). 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One of its functions is osmoregulatory."], "t": []}], "preferred_name": "contractile vacuole", "taxa": []} {"type": "biolink:CellularComponent", "ic": "90.860573823805353", "identifiers": [{"i": "UMLS:C1520647", "l": "15q25", "d": [], "t": []}, {"i": "NCIT:C24961", "l": "15q25", "d": ["A chromosome band present on 15q"], "t": []}], "preferred_name": "15q25", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C2246723", "l": "SBF transcription complex", "d": [], "t": []}], "preferred_name": "SBF transcription complex", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C3546517", "l": "CIA complex", "d": [], "t": []}], "preferred_name": "CIA complex", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C4235010", "l": "axon shaft", "d": [], "t": []}], "preferred_name": "axon shaft", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C1166792", "l": "kinesin II complex", "d": [], "t": []}], "preferred_name": "kinesin II complex", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C4512246", "l": "Entire free nerve ending", "d": [], "t": []}, {"i": "SNOMEDCT:726997003", "d": [], "t": []}], "preferred_name": "Entire free nerve ending", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C1662585", "l": "extrinsic component of cytoplasmic side of plasma membrane", "d": [], "t": []}], "preferred_name": "extrinsic component of cytoplasmic side of plasma membrane", "taxa": []} {"type": "biolink:CellularComponent", "ic": "100", "identifiers": [{"i": "GO:0044100", "l": "sporoplasm", "d": ["The complex infective apparatus corresponding to the central mass of cytoplasm within a spore that is injected into a host cell by various parasitic microorganisms."], "t": []}], "preferred_name": "sporoplasm", "taxa": []} {"type": "biolink:CellularComponent", "ic": "100", "identifiers": [{"i": "GO:0099164", "l": "postsynaptic specialization membrane of symmetric synapse", "d": ["The membrane component of the postsynaptic specialization of a symmetric synapse. 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The highly conserved, phosphorylated CDC37-Ser13 (vertebrates) or cdc37-Ser14 (yeast) is essential for complex assembly and target protein binding. CDC37-Ser13 (Ser14) is phosphorylated by Casein kinase II (CK2), which in turn is a target of CDC37 creating a positive feedback loop. 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The structures have a characteristic shape and size (10 mm long and 0.5 mm wide) and are surrounded with ribosomes. 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The multi-subunit PA700 complex binds two sites of the 20S proteasome and is composed of at least six related ATPases and approximately fifteen non-ATPase polypeptides. Each of the ATPases, PSMC1-6, contains an AAA (ATPases associated with diverse cellular activities) domain. A protein complex containing p42 and p50 enhances PA700 activation of the proteasome."], "t": []}], "preferred_name": "PA700 Regulatory Module", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C1166716", "l": "nuclear cyclin-dependent protein kinase holoenzyme complex location", "d": [], "t": []}], "preferred_name": "nuclear cyclin-dependent protein kinase holoenzyme complex location", "taxa": []} {"type": "biolink:CellularComponent", "ic": "100", "identifiers": [{"i": "GO:0140638", "l": "small ribosomal subunit processing complex", "d": ["A small heterodimeric protein complex that is required during early maturation of nascent 40S ribosomal subunits. 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Forms dimers and multimers of amyloid beta peptide 40 and peptide 42 (proteolytic cleavage products of amyloid beta A4 protein, also known as amyloid beta precursor protein). Mostly found in the extracellular space with a proportion occurring as membrane-bound species. Influences synaptic plasticity through various receptors, mediates dendritic spine loss leading to decreased synapse density, inhibits long-term potentiation (LTP) and enhances long-term depression (LTD). 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There is no known obligatory regulatory subunit. The class II PI3K (PI3KC2) subfamily of genes has members in vertebrates, worm and fly, but none in yeast."], "t": []}], "preferred_name": "phosphatidylinositol 3-kinase complex, class II", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C1749478", "l": "maturing face", "d": [], "t": []}], "preferred_name": "maturing face", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C2610832", "l": "DRM complex", "d": [], "t": []}], "preferred_name": "DRM complex", "taxa": []} {"type": "biolink:CellularComponent", "ic": "100", "identifiers": [{"i": "GO:0009316", "l": "3-isopropylmalate dehydratase complex", "d": ["A heterodimeric enzyme complex composed of subunits leuC and leuD. Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate."], "t": []}], "preferred_name": "3-isopropylmalate dehydratase complex", "taxa": []} {"type": "biolink:CellularComponent", "ic": "86.290860735708023", "identifiers": [{"i": "GO:0009513", "l": "etioplast", "d": ["A plastid arrested in the development of chloroplasts from proplastids due to absence of light or low light conditions."], "t": []}], "preferred_name": "etioplast", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C2247834", "l": "mitochondrial DNA-directed RNA polymerase complex", "d": [], "t": []}], "preferred_name": "mitochondrial DNA-directed RNA polymerase complex", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C4329100", "l": "anterior cell cortex", "d": [], "t": []}], "preferred_name": "anterior cell cortex", "taxa": []} {"type": "biolink:CellularComponent", "ic": "100", "identifiers": [{"i": "GO:0060110", "l": "basal layer of collagen and cuticulin-based cuticle extracellular matrix", "d": ["The layer of cuticle most closely apposed to the hypodermal cells. 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Also chaperones polypeptides from the endoplasmic reticulum retrotranslocation machinery to the proteasome, maintaining the solubility of substrates to improve ER-associated protein degradation (ERAD). 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{"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C4327251", "l": "podosome core", "d": [], "t": []}], "preferred_name": "podosome core", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C5154354", "l": "Barr bodies | Cervix | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Barr bodies | Cervix | Hematology and Cell counts", "taxa": []} {"type": "biolink:CellularComponent", "ic": "100", "identifiers": [{"i": "GO:0034717", "l": "Gemin6-Gemin7-unrip complex", "d": ["A protein complex that contains Gemin6, Gemin7, and unrip (STRAP), and can bind to snRNAs; may play a role in snRNP assembly."], "t": []}], "preferred_name": "Gemin6-Gemin7-unrip complex", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C1622086", "l": "filopodium membrane", "d": [], "t": []}], "preferred_name": "filopodium membrane", "taxa": []} {"type": "biolink:CellularComponent", "ic": 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{"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C1622013", "l": "extrinsic component of external side of cell outer membrane", "d": [], "t": []}], "preferred_name": "extrinsic component of external side of cell outer membrane", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C3546538", "l": "methanophenazine reducing hydrogenase complex", "d": [], "t": []}], "preferred_name": "methanophenazine reducing hydrogenase complex", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C3893638", "l": "dinoflagellate apical horn", "d": [], "t": []}], "preferred_name": "dinoflagellate apical horn", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C5137422", "l": "symbiont cell surface", "d": [], "t": []}], "preferred_name": "symbiont cell surface", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C3824424", "l": "STING complex", "d": [], "t": []}], "preferred_name": "STING complex", "taxa": []} {"type": "biolink:CellularComponent", "ic": "95.43028691190267", "identifiers": [{"i": "GO:0097522", "l": "protein-DNA ISRE complex", "d": ["A protein-DNA complex formed through interaction of the protein(s) with an interferon-stimulated response element (ISRE) in the DNA."], "t": []}], "preferred_name": "protein-DNA ISRE complex", "taxa": []} {"type": "biolink:CellularComponent", "ic": "82.601480381641593", "identifiers": [{"i": "GO:1990720", "l": "C2 axonemal microtubule", "d": ["One of two microtubules present in the axonemal central pair. 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They range in diameter from 1-3 um and are myelinated until they enter the granule cell layer. They give off collaterals to the deep cerebellar nuclei. They synapse extensively with the dendrites of Purkinje cells in the molecular layer, where each fiber branches repeatedly to climb along the Purkinje cell dendritic tree. Each Purkinje cell is innervated by only a single climbing fiber."], "t": []}], "preferred_name": "climbing fiber", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C5185139", "l": "Viral inclusion bodies | XXX | Cytology", "d": [], "t": []}], "preferred_name": "Viral inclusion bodies | XXX | Cytology", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C1180088", "l": "Wall of rough endoplasmic reticulum tubule", "d": [], "t": []}], "preferred_name": "Wall of rough endoplasmic reticulum tubule", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C1751136", "l": "junctional membrane complex", "d": [], "t": []}], "preferred_name": "junctional membrane complex", "taxa": []} {"type": "biolink:CellularComponent", "ic": "92.757176116311072", "identifiers": [{"i": "GO:0016942", "l": "insulin-like growth factor binding protein complex", "d": ["A complex of proteins which includes the insulin-like growth factor (IGF) and a number of IGF-binding proteins. 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In mammals the complex is composed of PIKFYVE, FIG4 and VAC14. In yeast it is composed of Atg18p, Fig4p, Fab1p, Vac14p and Vac7p."], "t": []}], "preferred_name": "PAS complex", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C1186710", "l": "Fibrillar component of nucleolus", "d": [], "t": []}], "preferred_name": "Fibrillar component of nucleolus", "taxa": []} {"type": "biolink:CellularComponent", "ic": "90.860573823805353", "identifiers": [{"i": "UMLS:C1521117", "l": "22q13.3", "d": [], "t": []}, {"i": "NCIT:C13908", "l": "22q13.3", "d": ["A chromosome band present on 22q"], "t": []}], "preferred_name": "22q13.3", "taxa": []} {"type": "biolink:CellularComponent", "ic": "92.757176116311072", "identifiers": [{"i": "GO:0005925", "l": "focal adhesion", "d": ["A cell-substrate junction that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments. 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These vesicles typically contain neuropeptides. They can be found in all parts of neurons, including the soma, dendrites, axonal swellings (varicosities) and synaptic terminals."], "t": []}], "preferred_name": "neuronal dense core vesicle", "taxa": []} {"type": "biolink:CellularComponent", "ic": "100", "identifiers": [{"i": "GO:0009380", "l": "excinuclease repair complex", "d": ["Any of the protein complexes formed by the UvrABC excinuclease system, which carries out nucleotide excision repair. Three different complexes are formed by the 3 proteins as they proceed through the excision repair process. First a complex consisting of two A subunits and two B subunits bind DNA and unwind it around the damaged site. Then, the A subunits disassociate leaving behind a stable complex between B subunits and DNA. Now, subunit C binds to this B+DNA complex and causes subunit B to nick the DNA on one side of the complex while subunit C nicks the DNA on the other side of the complex. 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The complex associates with Hsp90 and is thought to have a role in assembly of large protein or protein/nucleic acid complexes. 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Early complexes initiate double-stranded DNA unwinding. The core unit consists of a replicative helicase and a primase. The helicase further unwinds the DNA and recruits the polymerase machinery. The primase synthesizes RNA primers that act as templates for complementary stand replication by the polymerase machinery. 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Examples of this component are found in Fungi."], "t": []}], "preferred_name": "ascospore wall", "taxa": []} {"type": "biolink:CellularComponent", "ic": "90.860573823805353", "identifiers": [{"i": "UMLS:C1521453", "l": "5p13", "d": [], "t": []}, {"i": "NCIT:C25072", "l": "5p13", "d": ["A chromosome band present on 5p"], "t": []}], "preferred_name": "5p13", "taxa": []} {"type": "biolink:CellularComponent", "ic": "92.757176116311072", "identifiers": [{"i": "GO:0060200", "l": "clathrin-sculpted acetylcholine transport vesicle", "d": ["A clathrin-sculpted lipid bilayer membrane-enclosed vesicle after clathrin release and containing acetylcholine."], "t": []}], "preferred_name": "clathrin-sculpted acetylcholine transport vesicle", "taxa": []} {"type": "biolink:CellularComponent", "ic": "100", "identifiers": [{"i": "GO:0044834", "l": "retroviral intasome", "d": ["A tetramer of retroviral integrase subunits tightly associated with a pair of viral DNA ends. 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During mitotic division the chromatin condenses into chromosomes."], "t": []}], "preferred_name": "Chromatin", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C1325565", "l": "DASH complex", "d": [], "t": []}], "preferred_name": "DASH complex", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C1179890", "l": "Wall of Golgi cistern", "d": [], "t": []}], "preferred_name": "Wall of Golgi cistern", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C2337989", "l": "Protoplasm of acinar cell of pancreas", "d": [], "t": []}], "preferred_name": "Protoplasm of acinar cell of pancreas", "taxa": []} {"type": "biolink:CellularComponent", "ic": "100", "identifiers": [{"i": "GO:0097454", "l": "Schwann cell microvillus", "d": ["Small finger-like extension of a Schwann cell that contacts the nodal membrane."], "t": []}], "preferred_name": "Schwann cell microvillus", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C4322721", "l": "Intranuclear microtubule", "d": [], "t": []}], "preferred_name": "Intranuclear microtubule", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C3548460", "l": "glial cell projection", "d": [], "t": []}], "preferred_name": "glial cell projection", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C3896494", "l": "HDL-containing protein-lipid-RNA complex", "d": [], "t": []}], "preferred_name": "HDL-containing protein-lipid-RNA complex", "taxa": []} {"type": "biolink:CellularComponent", "ic": "95.43028691190267", "identifiers": [{"i": "GO:0035976", "l": "transcription factor AP-1 complex", "d": ["A heterodimeric transcription factor complex composed of proteins from the c-Fos, c-Jun, activating transcription factor (ATF) or JDP families. 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Cytoplasmic dynein complexes participate in many cytoplasmic transport activities in eukaryotes, such as mRNA localization, intermediate filament transport, nuclear envelope breakdown, apoptosis, transport of centrosomal proteins, mitotic spindle assembly, virus transport, kinetochore functions, and movement of signaling and spindle checkpoint proteins. Some complexes participate in intraflagellar transport. Subunits associated with the dynein heavy chain mediate association between dynein heavy chain and cargoes, and may include light chains and light intermediate chains."], "t": []}], "preferred_name": "cytoplasmic dynein complex", "taxa": []} {"type": "biolink:CellularComponent", "ic": "100", "identifiers": [{"i": "GO:0034662", "l": "CFTR-NHERF-ezrin complex", "d": ["A protein complex that contains ezrin, Na+/H+ exchanger regulatory factor (NHERF, also called EBP50), and two copies of the cystic fibrosis transmembrane conductance regulator (CFTR). The CFTR molecules interact with NHERF via their cytoplasmic tail domains; the complex is thought to link the CFTR channel to the actin cytoskeleton and contribute to the regulation of channel activity."], "t": []}], "preferred_name": "CFTR-NHERF-ezrin complex", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C2610684", "l": "SNARE complex (Stx1a, Snap25, Vamp8)", "d": [], "t": []}], "preferred_name": "SNARE complex (Stx1a, Snap25, Vamp8)", "taxa": []} {"type": "biolink:CellularComponent", "ic": "100", "identifiers": [{"i": "GO:0070724", "l": "BMP receptor complex", "d": ["A protein complex that acts as a receptor for bone morphogenetic proteins (BMPs); a homo- or heterodimer of type I and/or type II BMP receptor subunits."], "t": []}], "preferred_name": "BMP receptor complex", "taxa": []} {"type": "biolink:CellularComponent", "ic": "95.43028691190267", "identifiers": [{"i": "UMLS:C1515512", "l": "9q21", "d": [], "t": []}, {"i": "NCIT:C38181", "l": "9q21", "d": ["A chromosome band present on 9q"], "t": []}], "preferred_name": "9q21", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C1179100", "l": "Spiral filament of axoneme of flagellum", "d": [], "t": []}], "preferred_name": "Spiral filament of axoneme of flagellum", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C2754284", "l": "alpha5-beta1 integrin-fibronectin-tissue transglutaminase complex", "d": [], "t": []}], "preferred_name": "alpha5-beta1 integrin-fibronectin-tissue transglutaminase complex", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C3893951", "l": "actomyosin contractile ring actin filament", "d": [], "t": []}], "preferred_name": "actomyosin contractile ring actin filament", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C3824379", "l": "SsuD complex", "d": [], "t": []}], "preferred_name": "SsuD complex", "taxa": []} {"type": "biolink:CellularComponent", "ic": "90.860573823805353", "identifiers": [{"i": "UMLS:C1515526", "l": "9q33", "d": [], "t": []}, {"i": "NCIT:C13931", "l": "9q33", "d": ["A chromosome band present on 9q"], "t": []}], "preferred_name": "9q33", "taxa": []} {"type": "biolink:CellularComponent", "ic": "88.187463028213742", "identifiers": [{"i": "MESH:D000067128", "l": "Extracellular Vesicles", "d": [], "t": []}, {"i": "UMLS:C3894683", "l": "Extracellular Vesicles", "d": [], "t": []}, {"i": "NCIT:C153165", "l": "Extracellular Vesicle", "d": ["Bilayer membrane fragments present in the blood plasma that are released by different cell types upon activation or death. Extracellular vesicles are usually classified as either exosomes (formed by the membranes of intracellular compartments, 50-100 nm in diameter) and ectosomes (also called microparticles or microvesicles, formed from plasma membrane, 100-1000 nm in diameter)."], "t": []}], "preferred_name": "Extracellular Vesicles", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C5137451", "l": "phagolysosome vesicle membrane", "d": [], "t": []}], "preferred_name": "phagolysosome vesicle membrane", "taxa": []} {"type": "biolink:CellularComponent", "ic": "100", "identifiers": [{"i": "GO:0070732", "l": "spindle envelope", "d": ["An organelle envelope that surrounds the chromosomes and the central part of the spindle apparatus during mitosis and meiosis; observed in many invertebrates. The spindle envelope consists of membrane layers, called parafusorial membranes, derived from endoplasmic reticulum membrane; in male meiosis it forms during prometaphase and persists until early in the ensuing interphase."], "t": []}], "preferred_name": "spindle envelope", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C1623186", "l": "Tea1 cell-end complex", "d": [], "t": []}], "preferred_name": "Tea1 cell-end complex", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C1819046", "l": "mitotic septin complex", "d": [], "t": []}], "preferred_name": "mitotic septin complex", "taxa": []} {"type": "biolink:CellularComponent", "ic": "100", "identifiers": [{"i": "GO:0016590", "l": "ACF complex", "d": ["An ISWI complex that contains an ATPase subunit of the ISWI family (SNF2H in mammals, Isw2 in S. cerevisiae), an ACF1 homolog, and generally no other subunits, though Xenopus is an exception with a third non-conserved subunit. ACF plays roles in regulation of RNA polymerase II transcription and in DNA replication and repair."], "t": []}], "preferred_name": "ACF complex", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C2246460", "l": "Rad51B-Rad51C complex", "d": [], "t": []}], "preferred_name": "Rad51B-Rad51C complex", "taxa": []} {"type": "biolink:CellularComponent", "ic": "100", "identifiers": [{"i": "UMLS:C1520637", "l": "15q22-qter", "d": [], "t": []}, {"i": "NCIT:C26521", "l": "15q22-qter", "d": ["A chromosome band present on 15q"], "t": []}], "preferred_name": "15q22-qter", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C1183338", "l": "Region of microtubule", "d": [], "t": []}], "preferred_name": "Region of microtubule", "taxa": []} {"type": "biolink:CellularComponent", "ic": "100", "identifiers": [{"i": "GO:0005951", "l": "carbamoyl-phosphate synthase complex", "d": ["A protein complex that catalyzes the formation of carbamoyl phosphate; comprises a small subunit that binds and cleaves glutamine, and a large subunit that accepts the ammonia group cleaved from glutamine, binds all of the remaining substrates and effectors, and carries out all of the other catalytic events."], "t": []}], "preferred_name": "carbamoyl-phosphate synthase complex", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C1325644", "l": "glyoxysomal membrane", "d": [], "t": []}], "preferred_name": "glyoxysomal membrane", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C5814895", "l": "NMS complex", "d": [], "t": []}], "preferred_name": "NMS complex", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C1167313", "l": "ubiquitin ligase complex", "d": [], "t": []}], "preferred_name": "ubiquitin ligase complex", "taxa": []} {"type": "biolink:CellularComponent", "ic": "100", "identifiers": [{"i": "GO:0032171", "l": "germ tube septin cap", "d": ["A faint structure formed of septins found at the leading edge of growth in germ tubes of fungal cells growing filamentously. This cap of septins colocalizes with a region of the plasma membrane that is rich in ergosterol."], "t": []}], "preferred_name": "germ tube septin cap", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C2322725", "l": "Cytoplasm of epithelial cell of collecting duct of renal tubule", "d": [], "t": []}], "preferred_name": "Cytoplasm of epithelial cell of collecting duct of renal tubule", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C3546518", "l": "TAM protein secretion complex", "d": [], "t": []}], "preferred_name": "TAM protein secretion complex", "taxa": []} {"type": "biolink:CellularComponent", "ic": "95.43028691190267", "identifiers": [{"i": "NCIT:C13540", "l": "15p", "d": ["Proximal (short) arm of chromosome 15"], "t": []}], "preferred_name": "15p", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C2754145", "l": "post-mRNA release spliceosomal complex", "d": [], "t": []}], "preferred_name": "post-mRNA release spliceosomal complex", "taxa": []} {"type": "biolink:CellularComponent", "ic": "100", "identifiers": [{"i": "GO:0061825", "l": "podosome core", "d": ["The F-actin-rich core of an adhesion structure characterized by formation upon cell substrate contact and localization at the substrate-attached part of the cell."], "t": []}], "preferred_name": "podosome core", "taxa": []} {"type": "biolink:CellularComponent", "ic": "100", "identifiers": [{"i": "GO:0097075", "l": "interferon regulatory factor 3-interferon regulatory factor 7 complex", "d": ["An interferon regulatory factor complex that consists of a heterodimer of interferon regulatory factor 3 and interferon regulatory factor 7."], "t": []}], "preferred_name": "interferon regulatory factor 3-interferon regulatory factor 7 complex", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C3544395", "l": "R2TP/prefoldin-like complex", "d": [], "t": []}], "preferred_name": "R2TP/prefoldin-like complex", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C0598269", "l": "intracellular ground substance", "d": [], "t": []}], "preferred_name": "intracellular ground substance", "taxa": []} {"type": "biolink:CellularComponent", "ic": "100", "identifiers": [{"i": "GO:0097142", "l": "PUMA-BCL-2 complex", "d": ["A heterodimeric protein complex consisting of PUMA and BCL-2, members of the Bcl-2 family of anti- and proapoptotic regulators."], "t": []}], "preferred_name": "PUMA-BCL-2 complex", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C2612816", "l": "ITGAV-ITGB1 complex", "d": [], "t": []}], "preferred_name": "ITGAV-ITGB1 complex", "taxa": []} {"type": "biolink:CellularComponent", "ic": "100", "identifiers": [{"i": "UMLS:C1819995", "l": "Host Cell", "d": [], "t": []}, {"i": "NCIT:C93037", "l": "Host Cell", "d": [], "t": []}], "preferred_name": "Host Cell", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C1817249", "l": "laminin-6 complex", "d": [], "t": []}], "preferred_name": "laminin-6 complex", "taxa": []} {"type": "biolink:CellularComponent", "ic": "92.757176116311072", "identifiers": [{"i": "GO:0097450", "l": "astrocyte end-foot", "d": ["Terminal process of astrocyte abutting non-neuronal surfaces in the brain."], "t": []}], "preferred_name": "astrocyte end-foot", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C4691111", "l": "pathogen inclusion membrane", "d": [], "t": []}], "preferred_name": "pathogen inclusion membrane", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C1819065", "l": "hyphal septin ring", "d": [], "t": []}], "preferred_name": "hyphal septin ring", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C1523548", "l": "nucleocytoplasmic shuttling complex", "d": [], "t": []}], "preferred_name": "nucleocytoplasmic shuttling complex", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C1166814", "l": "chaperonine-containing T-complex location", "d": [], "t": []}], "preferred_name": "chaperonine-containing T-complex location", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C3824473", "l": "PDGF-CC dimer", "d": [], "t": []}], "preferred_name": "PDGF-CC dimer", "taxa": []} {"type": "biolink:CellularComponent", "ic": "87.171193469738924", "identifiers": [{"i": "UMLS:C1521288", "l": "3p22", "d": [], "t": []}, {"i": "NCIT:C13620", "l": "3p22", "d": ["A chromosome band present on 3p"], "t": []}], "preferred_name": "3p22", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C3546531", "l": "DNA polymerase III, core complex", "d": [], "t": []}], "preferred_name": "DNA polymerase III, core complex", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C0333780", "l": "Sarcoplasmic bodies", "d": [], "t": []}, {"i": "SNOMEDCT:2019006", "d": [], "t": []}], "preferred_name": "Sarcoplasmic bodies", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C3269089", "l": "PUMA-BCL-2 complex", "d": [], "t": []}], "preferred_name": "PUMA-BCL-2 complex", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C2611232", "l": "alpha2-beta1 integrin-alpha3(VI) complex", "d": [], "t": []}], "preferred_name": "alpha2-beta1 integrin-alpha3(VI) complex", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C2332262", "l": "Cell nucleus of connective tissue cell", "d": [], "t": []}], "preferred_name": "Cell nucleus of connective tissue cell", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C5426684", "l": "Neuronal intermediate filament heavy chain", "d": [], "t": []}], "preferred_name": "Neuronal intermediate filament heavy chain", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C2247158", "l": "Rpd3L complex", "d": [], "t": []}], "preferred_name": "Rpd3L complex", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C3821306", "l": "host cell synaptic vesicle", "d": [], "t": []}], "preferred_name": "host cell synaptic vesicle", "taxa": []} {"type": "biolink:CellularComponent", "ic": "95.43028691190267", "identifiers": [{"i": "GO:0032299", "l": "ribonuclease H2 complex", "d": ["A protein complex that possesses ribonuclease H activity, in which the catalytic subunit is a member of the RNase H2 (or HII) class. For example, in Saccharomyces the complex contains Rnh201p, Rnh202p and Rnh203p."], "t": []}], "preferred_name": "ribonuclease H2 complex", "taxa": []} {"type": "biolink:CellularComponent", "ic": "100", "identifiers": [{"i": "GO:0097417", "l": "nematosome", "d": ["Cytoplasmic, ball-like inclusion resembling a nucleolus and consisting of a convoluted network of electron-opaque strands embedded in a less dense matrix. It measures approximately 0.9 microns and lacks a limiting membrane. Its strands (diameter = 400-600 A) appear to be made of an entanglement of tightly packed filaments and particles approximately 25-50 A thick. Cytochemical studies suggest the presence of nonhistone proteins and some RNA. Usually only one such structure is present in a cell, and it appears to occur in most ganglion cells. Although they can be seen anywhere in the cell body, nematosomes are typically located in the perinuclear cytoplasm, where they are often associated with smooth-surfaced and coated vesicles."], "t": []}], "preferred_name": "nematosome", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C2338699", "l": "Set of cytoplasmic organelles of epithelial cell of prostate", "d": [], "t": []}], "preferred_name": "Set of cytoplasmic organelles of epithelial cell of prostate", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C2611791", "l": "PA28gamma-20S proteasome", "d": [], "t": []}], "preferred_name": "PA28gamma-20S proteasome", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C1657453", "l": "extrinsic component of mitochondrial inner membrane", "d": [], "t": []}], "preferred_name": "extrinsic component of mitochondrial inner membrane", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C5451535", "l": "mitotic nuclear bridge", "d": [], "t": []}], "preferred_name": "mitotic nuclear bridge", "taxa": []} {"type": "biolink:CellularComponent", "ic": "90.860573823805353", "identifiers": [{"i": "GO:0060106", "l": "cortical layer of collagen and cuticulin-based cuticle extracellular matrix", "d": ["The cuticle layer that lies directly beneath the lipid-containing epicuticle. The cortical layer contains collagens and insoluble, non-collagenous cuticulins and is characterized by a distinct annular pattern consisting of regularly spaced annular ridges delineated by annular furrows. An example of this component is found in Caenorhabditis elegans."], "t": []}], "preferred_name": "cortical layer of collagen and cuticulin-based cuticle extracellular matrix", "taxa": []} {"type": "biolink:CellularComponent", "ic": "90.860573823805353", "identifiers": [{"i": "UMLS:C1520293", "l": "10q24.3-10qter", "d": [], "t": []}, {"i": "NCIT:C13641", "l": "10q24.3-10qter", "d": ["A chromosome band present on 10q"], "t": []}], "preferred_name": "10q24.3-10qter", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C4326881", "l": "amyloid beta oligomer", "d": [], "t": []}], "preferred_name": "amyloid beta oligomer", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C1166693", "l": "Metaphase chromosome", "d": [], "t": []}], "preferred_name": "Metaphase chromosome", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C3271479", "l": "rhabdomere microvillus", "d": [], "t": []}], "preferred_name": "rhabdomere microvillus", "taxa": []} {"type": "biolink:CellularComponent", "ic": "86.290860735708023", "identifiers": [{"i": "UMLS:C1520993", "l": "1q22-q23", "d": [], "t": []}, {"i": "NCIT:C28648", "l": "1q22-q23", "d": ["A chromosome band present on 1q"], "t": []}], "preferred_name": "1q22-q23", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C3548492", "l": "host cell endocytic vesicle membrane", "d": [], "t": []}], "preferred_name": "host cell endocytic vesicle membrane", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C5450979", "l": "EGO complex", "d": [], "t": []}], "preferred_name": "EGO complex", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C2754267", "l": "ITGA2-ITGB1-CD47 complex", "d": [], "t": []}], "preferred_name": "ITGA2-ITGB1-CD47 complex", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C2754872", "l": "gamma-catenin-TCF7L2 complex", "d": [], "t": []}], "preferred_name": "gamma-catenin-TCF7L2 complex", "taxa": []} {"type": "biolink:CellularComponent", "ic": "100", "identifiers": [{"i": "GO:0071564", "l": "npBAF complex", "d": ["A SWI/SNF-type complex that is found in neural stem or progenitor cells, and in human contains actin and proteins encoded by the ARID1A/BAF250A or ARID1B/BAF250B, SMARCD1/BAF60A, SMARCD3/BAF60C, SMARCA2/BRM/BAF190B, SMARCA4/BRG1/BAF190A, SMARCB1/BAF47, SMARCC1/BAF155, SMARCE1/BAF57, SMARCC2/BAF170, PHF10/BAF45A, ACTL6A/BAF53A genes. The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells."], "t": []}], "preferred_name": "npBAF complex", "taxa": []} {"type": "biolink:CellularComponent", "ic": "92.757176116311072", "identifiers": [{"i": "UMLS:C1520371", "l": "11p15.3-p15.1", "d": [], "t": []}, {"i": "NCIT:C41012", "l": "11p15.3-p15.1", "d": ["A chromosome band present on 11p"], "t": []}], "preferred_name": "11p15.3-p15.1", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C4690723", "l": "NAGS/NAGK complex", "d": [], "t": []}], "preferred_name": "NAGS/NAGK complex", "taxa": []} {"type": "biolink:CellularComponent", "ic": "100", "identifiers": [{"i": "GO:0009322", "l": "trimethylamine-N-oxide reductase complex", "d": ["An enzyme complex that catalyzes the reduction of trimethylamine N-oxide to trimethylamine."], "t": []}], "preferred_name": "trimethylamine-N-oxide reductase complex", "taxa": []} {"type": "biolink:CellularComponent", "ic": "100", "identifiers": [{"i": "GO:0140261", "l": "BCOR complex", "d": ["A protein-containing complex that monoubiquitinates histone H2A on K119, thus it facilitates the maintenance of the transcriptionally repressive state of some genes, such as BCL6. It consists of the corepressor BCOR or BCORL1, a Polycomb group (PcG) and a SCF ubiquitin ligase subcomplexes. In mammals, the core subunits of the complex include the PcG and PcG-associated proteins NSPC1, RING1, RNF2, and RYBP and the components of the SCF ubiquitin ligase, SKP1, and FBXL10."], "t": []}], "preferred_name": "BCOR complex", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C3896361", "l": "perinuclear endoplasmic reticulum membrane", "d": [], "t": []}], "preferred_name": "perinuclear endoplasmic reticulum membrane", "taxa": []} {"type": "biolink:CellularComponent", "ic": "95.43028691190267", "identifiers": [{"i": "GO:0031680", "l": "G-protein beta/gamma-subunit complex", "d": ["The heterodimer formed by the beta and gamma subunits of a heterotrimeric G protein, which dissociates from the alpha subunit upon guanine nuclotide exchange."], "t": []}], "preferred_name": "G-protein beta/gamma-subunit complex", "taxa": []} {"type": "biolink:CellularComponent", "ic": "100", "identifiers": [{"i": "GO:0070464", "l": "alphav-beta3 integrin-collagen alpha3(VI) complex", "d": ["A protein complex that consists of an alphav-beta3 integrin complex bound to the alpha3 chain of type VI collagen; the integrin binds most strongly to unfolded collagen."], "t": []}], "preferred_name": "alphav-beta3 integrin-collagen alpha3(VI) complex", "taxa": []} {"type": "biolink:CellularComponent", "ic": "73.825046931202166", "identifiers": [{"i": "GO:0034358", "l": "plasma lipoprotein particle", "d": ["A spherical particle with a hydrophobic core of triglycerides and/or cholesterol esters, surrounded by an amphipathic monolayer of phospholipids, cholesterol and apolipoproteins. Plasma lipoprotein particles transport lipids, which are non-covalently associated with the particles, in the blood or lymph."], "t": []}], "preferred_name": "plasma lipoprotein particle", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C2248679", "l": "telomere complex", "d": [], "t": []}], "preferred_name": "telomere complex", "taxa": []} {"type": "biolink:CellularComponent", "ic": "100", "identifiers": [{"i": "GO:0009577", "l": "elaioplast stroma", "d": ["The space enclosed by the double membrane of an elaioplast."], "t": []}], "preferred_name": "elaioplast stroma", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C2610534", "l": "fertilization envelope", "d": [], "t": []}], "preferred_name": "fertilization envelope", "taxa": []} {"type": "biolink:CellularComponent", "ic": "100", "identifiers": [{"i": "GO:0098032", "l": "icosahedral viral capsid, collar fiber", "d": ["A fiber attached to the collar structure of some icosahedral viral capsids."], "t": []}], "preferred_name": "icosahedral viral capsid, collar fiber", "taxa": []} {"type": "biolink:CellularComponent", "ic": "100", "identifiers": [{"i": "GO:0098029", "l": "icosahedral viral capsid, spike", "d": ["A short structure attached to an icosahedral virion capsid, and used for attachment to the host cell."], "t": []}], "preferred_name": "icosahedral viral capsid, spike", "taxa": []} {"type": "biolink:CellularComponent", "ic": "100", "identifiers": [{"i": "UMLS:C1520475", "l": "12p13-p12", "d": [], "t": []}, {"i": "NCIT:C28611", "l": "12p13-p12", "d": ["A chromosome band present on 12p"], "t": []}], "preferred_name": "12p13-p12", "taxa": []} {"type": "biolink:CellularComponent", "ic": "100", "identifiers": [{"i": "GO:0031381", "l": "viral RNA-directed RNA polymerase complex", "d": ["A virus-specific protein complex that possesses RNA-dependent RNA polymerase activity and replicates the genome of an RNA virus."], "t": []}], "preferred_name": "viral RNA-directed RNA polymerase complex", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C2247014", "l": "Elongator core complex", "d": [], "t": []}], "preferred_name": "Elongator core complex", "taxa": []} {"type": "biolink:CellularComponent", "ic": "95.43028691190267", "identifiers": [{"i": "GO:1990909", "l": "Wnt signalosome", "d": ["A multiprotein protein complex containing membrane-localized Wnt receptors and cytosolic protein complexes, which is capable of transmitting the Wnt signal. Contains at least a Wnt protein, LRP5 or LRP6, a member of the Frizzled (Fz) family, Axin and and a Dishevelled (DVL) protein."], "t": []}], "preferred_name": "Wnt signalosome", "taxa": []} {"type": "biolink:CellularComponent", "ic": "95.43028691190267", "identifiers": [{"i": "UMLS:C1521013", "l": "1q41-q44", "d": [], "t": []}, {"i": "NCIT:C26385", "l": "1q41-q44", "d": ["A chromosome band present on 1q"], "t": []}], "preferred_name": "1q41-q44", "taxa": []} {"type": "biolink:CellularComponent", "ic": "100", "identifiers": [{"i": "GO:0000807", "l": "Z chromosome", "d": ["The sex chromosome present in both sexes of species in which the female is the heterogametic sex. Two copies of the Z chromosome are present in each somatic cell of males and one copy is present in females."], "t": []}], "preferred_name": "Z chromosome", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C5197821", "l": "Polyhedral Occlusion Body", "d": [], "t": []}], "preferred_name": "Polyhedral Occlusion Body", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C2754268", "l": "alphaIIb-beta3 integrin-CD9 complex", "d": [], "t": []}], "preferred_name": "alphaIIb-beta3 integrin-CD9 complex", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C3896521", "l": "survivin complex", "d": [], "t": []}], "preferred_name": "survivin complex", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C2324173", "l": "Telocentric centromere", "d": [], "t": []}], "preferred_name": "Telocentric centromere", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C2335623", "l": "Set of reticular nuclei of medulla oblongata", "d": [], "t": []}], "preferred_name": "Set of reticular nuclei of medulla oblongata", "taxa": []} {"type": "biolink:CellularComponent", "ic": "100", "identifiers": [{"i": "NCIT:C13661", "l": "Cyclic AMP Response Element", "d": ["A promoter sequence which interacts with CRE binding proteins to modulate gene expression in response to the level of cAMP in the cell."], "t": []}], "preferred_name": "Cyclic AMP Response Element", "taxa": []} {"type": "biolink:CellularComponent", "ic": "71.805212968330153", "identifiers": [{"i": "GO:0042175", "l": "nuclear outer membrane-endoplasmic reticulum membrane network", "d": ["The continuous network of membranes encompassing the nuclear outer membrane and the endoplasmic reticulum membrane."], "t": []}], "preferred_name": "nuclear outer membrane-endoplasmic reticulum membrane network", "taxa": []} {"type": "biolink:CellularComponent", "ic": "100", "identifiers": [{"i": "GO:0097423", "l": "mitochondrion-associated adherens complex", "d": ["An organelle arrangement comprised of the following elements: a mitochondrion positioned near the presynaptic membrane; an electron-dense mitochondrial plaque adjacent to the outer mitochondrial membrane that faces the presynaptic membrane; filament-like elements appearing to link the mitochondrial plaque to a cell-cell junction region (sometimes termed punctum adherens); tubular or vesicular-appearing membrane (also called vesicular chain) interposed among the filaments. Mitochondrion-associated adherens complexes were initially described in the dorsal horn of the spinal cord. They are found in calyces and other large terminals of the auditory brainstem, and in a variety of mammalian species including humans."], "t": []}], "preferred_name": "mitochondrion-associated adherens complex", "taxa": []} {"type": "biolink:CellularComponent", "ic": "100", "identifiers": [{"i": "GO:0032936", "l": "SREBP-SCAP complex", "d": ["A protein complex formed by the association of sterol regulatory element binding protein (SREBP) and SREBP-cleavage-activating protein (SCAP) in the ER membrane; in the absence of sterols, the SREBP-SCAP complex is packaged into COPII vesicles and travels to the Golgi apparatus to be processed."], "t": []}], "preferred_name": "SREBP-SCAP complex", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C4236513", "l": "cell cortex region", "d": [], "t": []}], "preferred_name": "cell cortex region", "taxa": []} {"type": "biolink:CellularComponent", "ic": "57.158759609145463", "identifiers": [{"i": "GO:0097708", "l": "intracellular vesicle", "d": ["Any vesicle that is part of the intracellular region."], "t": []}], "preferred_name": "intracellular vesicle", "taxa": []} {"type": "biolink:CellularComponent", "ic": "100", "identifiers": [{"i": "GO:0110158", "l": "calpain complex", "d": ["A calcium-dependent protease complex that processes its substrate by limited proteolysis rather than degrading it. In some cases limited proteolysis is required for the activation of its substrate."], "t": []}], "preferred_name": "calpain complex", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C1179116", "l": "A-tubule of triplet microtubule of kinetosome of flagellum", "d": [], "t": []}], "preferred_name": "A-tubule of triplet microtubule of kinetosome of flagellum", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C1166952", "l": "chloroplast inner membrane", "d": [], "t": []}], "preferred_name": "chloroplast inner membrane", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C1817483", "l": "katanin complex", "d": [], "t": []}], "preferred_name": "katanin complex", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C2612401", "l": "RC complex", "d": [], "t": []}], "preferred_name": "RC complex", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C1179129", "l": "Stereocilium of vestibular sensory cell", "d": [], "t": []}], "preferred_name": "Stereocilium of vestibular sensory cell", "taxa": []} {"type": "biolink:CellularComponent", "ic": "100", "identifiers": [{"i": "GO:0000806", "l": "Y chromosome", "d": ["The sex chromosome present in males of species in which the male is the heterogametic sex; generally, the sex chromosome that pairs with the X chromosome in the heterogametic sex. The Y chromosome is absent from the cells of females and present in one copy in the somatic cells of males."], "t": []}], "preferred_name": "Y chromosome", "taxa": []} {"type": "biolink:CellularComponent", "ic": "95.43028691190267", "identifiers": [{"i": "GO:0008275", "l": "gamma-tubulin small complex", "d": ["A complex usually comprising two gamma-tubulin molecules and two conserved non-tubulin proteins. Some gamma-tubulin small complexes are thought to be the repeating unit making up the core of the gamma-tubulin ring complex."], "t": []}], "preferred_name": "gamma-tubulin small complex", "taxa": []} {"type": "biolink:CellularComponent", "ic": "100", "identifiers": [{"i": "GO:0071339", "l": "MLL1 complex", "d": ["A protein complex that can methylate lysine-4 of histone H3. MLL1/MLL is the catalytic methyltransferase subunit, and the complex also contains the core components ASH2L, HCFC1/HCF1 WDR5 and RBBP5."], "t": []}], "preferred_name": "MLL1 complex", "taxa": []} {"type": "biolink:CellularComponent", "ic": "95.43028691190267", "identifiers": [{"i": "GO:0009275", "l": "Gram-positive-bacterium-type cell wall", "d": ["A layer of peptidoglycan found outside of the cytoplasmic membrane. The peptidoglycan is relatively thick (20-80nm) and retains the primary stain of the Gram procedure, thus cells appear blue after Gram stain. The cell walls often contain teichoic acids (acidic anionic polysaccharides) bound to the peptidoglycan. Examples of this component are found in Gram-positive bacteria."], "t": []}], "preferred_name": "Gram-positive-bacterium-type cell wall", "taxa": []} {"type": "biolink:CellularComponent", "ic": "100", "identifiers": [{"i": "GO:0034657", "l": "GID complex", "d": ["A protein complex with ubiquitin ligase activity that, in Saccharomyces cerevisiae, is involved in proteasomal degradation of fructose-1,6-bisphosphatase (FBPase) and phosphoenolpyruvate carboxykinase during the transition from gluconeogenic to glycolytic growth conditions. It appears to play a broader role in cellular homeostasis and development in other species."], "t": []}], "preferred_name": "GID complex", "taxa": []} {"type": "biolink:CellularComponent", "ic": "82.601480381641593", "identifiers": [{"i": "GO:1990719", "l": "C1 axonemal microtubule", "d": ["One of two microtubules present in the axonemal central pair. It is distinguishable from the C2 axonemal microtubule (also called C2 tubule) by the presence of differing protein components of the projections."], "t": []}], "preferred_name": "C1 axonemal microtubule", "taxa": []} {"type": "biolink:CellularComponent", "ic": "100", "identifiers": [{"i": "GO:0097220", "l": "simple sieve plate", "d": ["A sieve plate that contains a single specialized sieve area."], "t": []}], "preferred_name": "simple sieve plate", "taxa": []} {"type": "biolink:CellularComponent", "ic": "100", "identifiers": [{"i": "GO:0097426", "l": "glial filament", "d": ["An intermediate filament composed of glial fibrillary acidic protein (GFAP) and found in astrocytes."], "t": []}], "preferred_name": "glial filament", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "MESH:C000719328", "l": "smoker's inclusion bodies", "d": [], "t": []}, {"i": "UMLS:C5565036", "l": "smoker's inclusion bodies", "d": [], "t": []}], "preferred_name": "smoker's inclusion bodies", "taxa": []} {"type": "biolink:CellularComponent", "ic": "100", "identifiers": [{"i": "GO:1990350", "l": "glucose transporter complex", "d": ["A protein complex facilitating glucose transport into, out of or within a cell, or between cells."], "t": []}], "preferred_name": "glucose transporter complex", "taxa": []} {"type": "biolink:CellularComponent", "ic": "95.43028691190267", "identifiers": [{"i": "GO:0044295", "l": "axonal growth cone", "d": ["The migrating motile tip of a growing nerve cell axon."], "t": []}], "preferred_name": "axonal growth cone", "taxa": []} {"type": "biolink:CellularComponent", "ic": "100", "identifiers": [{"i": "UMLS:C1521618", "l": "7p14-p12", "d": [], "t": []}, {"i": "NCIT:C28584", "l": "7p14-p12", "d": ["A chromosome band present on 7p"], "t": []}], "preferred_name": "7p14-p12", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C3824361", "l": "methionine-importing ABC transporter complex", "d": [], "t": []}], "preferred_name": "methionine-importing ABC transporter complex", "taxa": []} {"type": "biolink:CellularComponent", "ic": "100", "identifiers": [{"i": "GO:0033551", "l": "monopolin complex", "d": ["A protein complex required for clamping microtubule binding sites, ensuring orientation of sister kinetochores to the same pole (mono-orientation) during meiosis I. In the yeast S. cerevisiae this complex consists of Csm1p, Lrs4p, Hrr25p and Mam1p; in S. pombe Psc1 and Mde4 have been identified as subunits."], "t": []}], "preferred_name": "monopolin complex", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C2610683", "l": "endobrevin-SNAP-25-syntaxin-1a complex", "d": [], "t": []}], "preferred_name": "endobrevin-SNAP-25-syntaxin-1a complex", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C2338158", "l": "Condensed cytoplasmic chromosome", "d": [], "t": []}], "preferred_name": "Condensed cytoplasmic chromosome", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C2752597", "l": "tRNA thiouridylase", "d": [], "t": []}], "preferred_name": "tRNA thiouridylase", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C4327127", "l": "DNA methyltransferase complex", "d": [], "t": []}], "preferred_name": "DNA methyltransferase complex", "taxa": []} {"type": "biolink:CellularComponent", "ic": "92.757176116311072", "identifiers": [{"i": "UMLS:C1520861", "l": "19q13.2-q13.3", "d": [], "t": []}, {"i": "NCIT:C13136", "l": "19q13.2-q13.3", "d": ["A chromosome band present on 19q"], "t": []}], "preferred_name": "19q13.2-q13.3", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C1622108", "l": "cytosolic proteasome core complex", "d": [], "t": []}], "preferred_name": "cytosolic proteasome core complex", "taxa": []} {"type": "biolink:CellularComponent", "ic": "95.43028691190267", "identifiers": [{"i": "GO:0009705", "l": "plant-type vacuole membrane", "d": ["The lipid bilayer surrounding a vacuole that retains the same shape regardless of cell cycle phase. The membrane separates its contents from the cytoplasm of the cell. An example of this component is found in Arabidopsis thaliana."], "t": []}], "preferred_name": "plant-type vacuole membrane", "taxa": []} {"type": "biolink:CellularComponent", "ic": "92.757176116311072", "identifiers": [{"i": "GO:0099091", "l": "postsynaptic specialization, intracellular component", "d": ["A network of proteins adjacent to the postsynaptic membrane. Its major components include the proteins that spatially and functionally organize neurotransmitter receptors in the adjacent membrane, such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components."], "t": []}], "preferred_name": "postsynaptic specialization, intracellular component", "taxa": []} {"type": "biolink:CellularComponent", "ic": "95.43028691190267", "identifiers": [{"i": "GO:0016465", "l": "chaperonin ATPase complex", "d": ["Multisubunit protein complex with 2x7 (Type I, in most cells) or 2x8 (Type II, in Archaea) ATP-binding sites involved in maintaining an unfolded polypeptide structure before folding or to entry into mitochondria and chloroplasts."], "t": []}], "preferred_name": "chaperonin ATPase complex", "taxa": []} {"type": "biolink:CellularComponent", "ic": "100", "identifiers": [{"i": "UMLS:C1511969", "l": "Dimeric Tubulin Molecule", "d": [], "t": []}, {"i": "NCIT:C32464", "l": "Dimeric Tubulin Molecule", "d": ["A protein complex containing one alpha tubulin and one beta tubulin."], "t": []}], "preferred_name": "Dimeric Tubulin Molecule", "taxa": []} {"type": "biolink:CellularComponent", "ic": "92.757176116311072", "identifiers": [{"i": "UMLS:C1511498", "l": "Contractile System", "d": [], "t": []}, {"i": "NCIT:C13403", "l": "Contractile System", "d": ["Contractile system directs cell movement and is responsible for maintaining or changing cell shape. The system consists of many specialized cytoplasmic proteins, including actin, myosin, tubulin, kinesin, other cytoskeletal and contractile system proteins. (NCI)"], "t": []}], "preferred_name": "Contractile System", "taxa": []} {"type": "biolink:CellularComponent", "ic": "85.51435223262213", "identifiers": [{"i": "UMLS:C1521663", "l": "7q36", "d": [], "t": []}, {"i": "NCIT:C25116", "l": "7q36", "d": ["A chromosome band present on 7q"], "t": []}], "preferred_name": "7q36", "taxa": []} {"type": "biolink:CellularComponent", "ic": "95.43028691190267", "identifiers": [{"i": "GO:0033256", "l": "I-kappaB/NF-kappaB complex", "d": ["A protein complex containing an inhibitory-kappaB (I-kappaB/IKB) protein and one or more copies of an NF-kappaB protein. In the resting state, NF-kappaB dimers are bound to I-kappaB proteins, sequestering NF-kappaB in the cytoplasm."], "t": []}], "preferred_name": "I-kappaB/NF-kappaB complex", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C4236707", "l": "presynaptic active zone cytoplasmic component", "d": [], "t": []}], "preferred_name": "presynaptic active zone cytoplasmic component", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C1166844", "l": "docking protein complex", "d": [], "t": []}], "preferred_name": "docking protein complex", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C3269090", "l": "PUMA-BCL-xl complex", "d": [], "t": []}], "preferred_name": "PUMA-BCL-xl complex", "taxa": []} {"type": "biolink:CellularComponent", "ic": "100", "identifiers": [{"i": "GO:0043512", "l": "inhibin A complex", "d": ["Heterodimeric hormone composed of an inhibin alpha subunit complexed with an inhibin beta-A subunit."], "t": []}], "preferred_name": "inhibin A complex", "taxa": []} {"type": "biolink:CellularComponent", "ic": "92.757176116311072", "identifiers": [{"i": "GO:0044159", "l": "host thylakoid", "d": ["A membranous cellular structure within the host cell that bears the photosynthetic pigments in plants, algae, and cyanobacteria. In cyanobacteria thylakoids are of various shapes and are attached to, or continuous with, the host plasma membrane. In eukaryotic host cells they are flattened, membrane-bounded disk-like structures located in the chloroplasts; in the chloroplasts of higher plants the thylakoids form dense stacks called grana. Isolated thylakoid preparations can carry out photosynthetic electron transport and the associated phosphorylation."], "t": []}], "preferred_name": "host thylakoid", "taxa": []} {"type": "biolink:CellularComponent", "ic": "92.757176116311072", "identifiers": [{"i": "GO:0005834", "l": "heterotrimeric G-protein complex", "d": ["Any of a family of heterotrimeric GTP-binding and hydrolyzing proteins; they belong to a superfamily of GTPases that includes monomeric proteins such as EF-Tu and RAS. Heterotrimeric G-proteins consist of three subunits; the alpha subunit contains the guanine nucleotide binding site and possesses GTPase activity; the beta and gamma subunits are tightly associated and function as a beta-gamma heterodimer; extrinsic plasma membrane proteins (cytoplasmic face) that function as a complex to transduce signals from G protein-coupled receptors to an effector protein."], "t": []}], "preferred_name": "heterotrimeric G-protein complex", "taxa": []} {"type": "biolink:CellularComponent", "ic": "90.860573823805353", "identifiers": [{"i": "UMLS:C1520864", "l": "19q13.31", "d": [], "t": []}, {"i": "NCIT:C28650", "l": "19q13.31", "d": ["A chromosome band present on 19q"], "t": []}], "preferred_name": "19q13.31", "taxa": []} {"type": "biolink:CellularComponent", "ic": "100", "identifiers": [{"i": "GO:0106037", "l": "apicomedial cortex", "d": ["The region that lies just beneath the plasma membrane in the middle of the apical edge of a cell."], "t": []}], "preferred_name": "apicomedial cortex", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C1325818", "l": "ribozyme location", "d": [], "t": []}], "preferred_name": "ribozyme location", "taxa": []} {"type": "biolink:CellularComponent", "ic": "100", "identifiers": [{"i": "GO:0046809", "l": "replication compartment", "d": ["Globular nuclear domains where the transcription and replication of the viral genome occurs. 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This trimeric complex is responsible for recognizing and binding to cargo molecules. The complex comprises three Vps proteins in both yeast and mammalian cells: Vps35p, Vps29p, and Vps26p in yeast, and VPS35, VPS29 and VPS26A or VPS26B in mammals."], "t": []}], "preferred_name": "retromer, cargo-selective complex", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C1819697", "l": "myosin III complex", "d": [], "t": []}], "preferred_name": "myosin III complex", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C2613150", "l": "FHL3-CREB complex", "d": [], "t": []}], "preferred_name": "FHL3-CREB complex", "taxa": []} {"type": "biolink:CellularComponent", "ic": "100", "identifiers": [{"i": "GO:0071756", "l": "pentameric IgM immunoglobulin complex", "d": ["A circulating form of IgM consisting of a pentamer of IgM core units with a single J chain polypeptide."], "t": []}], "preferred_name": "pentameric IgM immunoglobulin complex", "taxa": []} {"type": "biolink:CellularComponent", "ic": "95.43028691190267", "identifiers": [{"i": "GO:0020026", "l": "merozoite dense granule", "d": ["Electron-dense organelle with a granular internal matrix found throughout the merozoite life cycle stage of apicomplexan parasites; 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"MESH:D014998", "l": "Y Chromosome", "d": [], "t": []}, {"i": "UMLS:C0043381", "l": "Y Chromosome", "d": [], "t": []}, {"i": "SNOMEDCT:5421003", "d": [], "t": []}], "preferred_name": "Y Chromosome", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C3824567", "l": "terminal web", "d": [], "t": []}], "preferred_name": "terminal web", "taxa": []} {"type": "biolink:CellularComponent", "ic": "95.43028691190267", "identifiers": [{"i": "GO:0005763", "l": "mitochondrial small ribosomal subunit", "d": ["The smaller of the two subunits of a mitochondrial ribosome."], "t": []}], "preferred_name": "mitochondrial small ribosomal subunit", "taxa": []} {"type": "biolink:CellularComponent", "ic": "100", "identifiers": [{"i": "GO:0032444", "l": "activin responsive factor complex", "d": ["A transcriptionally active complex that binds to an activin response element (ARE) in the promoter of target genes, and is composed of two SMAD2 proteins, one SMAD4 protein and 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The parts of the sphere organelle have distinct compositions, including splicing snRNAs and proteins."], "t": []}], "preferred_name": "sphere organelle", "taxa": []} {"type": "biolink:CellularComponent", "ic": "85.51435223262213", "identifiers": [{"i": "UMLS:C1520581", "l": "14q12", "d": [], "t": []}, {"i": "NCIT:C13656", "l": "14q12", "d": ["A chromosome band present on 14q"], "t": []}], "preferred_name": "14q12", "taxa": []} {"type": "biolink:CellularComponent", "ic": "83.090052188295473", "identifiers": [{"i": "GO:0045240", "l": "alpha-ketoacid dehydrogenase complex", "d": ["A multi-enzyme complex that catalyzes the oxidative decarboxylation of an alpha-ketoacid - pyruvate, a branched-chain alpha-ketoacid or alpha-ketoglutarate (also known as 2-oxoglutarate). 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Additional proteins may also be present."], "t": []}], "preferred_name": "alpha-ketoacid dehydrogenase complex", "taxa": []} {"type": "biolink:CellularComponent", "ic": "100", "identifiers": [{"i": "GO:0036025", "l": "protein C inhibitor-TMPRSS11E complex", "d": ["A heterodimeric protein complex that contains protein C inhibitor (SERPINA5) and transmembrane protease serine 11E (TMPRSS11E); formation of the complex inhibits the serine protease activity of transmembrane protease serine 11E."], "t": []}], "preferred_name": "protein C inhibitor-TMPRSS11E complex", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C4236857", "l": "bacterial outer membrane vesicle", "d": [], "t": []}], "preferred_name": "bacterial outer membrane vesicle", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "MESH:D000088462", "l": "Microneme", "d": [], "t": []}, {"i": "UMLS:C1166650", "l": "Microneme", "d": [], "t": []}], "preferred_name": "Microneme", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C4327173", "l": "chromatin lock complex", "d": [], "t": []}], "preferred_name": "chromatin lock complex", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C0333830", "l": "Döhle body", "d": [], "t": []}, {"i": "SNOMEDCT:43949008", "d": [], "t": []}], "preferred_name": "Döhle body", "taxa": []} {"type": "biolink:CellularComponent", "ic": "92.757176116311072", "identifiers": [{"i": "UMLS:C1520646", "l": "15q24-q25", "d": [], "t": []}, {"i": "NCIT:C13999", "l": "15q24-q25", "d": ["A chromosome band present on 15q"], "t": []}], "preferred_name": "15q24-q25", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "MESH:D035341", "l": "Telomeric Repeat Binding Protein 2", "d": [], "t": []}], "preferred_name": "Telomeric Repeat Binding Protein 2", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C2752596", "l": "Cut1-Cut2 complex", "d": [], "t": []}], "preferred_name": "Cut1-Cut2 complex", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C2246503", "l": "Cvt vesicle", "d": [], "t": []}], "preferred_name": "Cvt vesicle", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C1167222", "l": "glycine-gated chloride channel complex", "d": [], "t": []}], "preferred_name": "glycine-gated chloride channel complex", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C1167147", "l": "snRNA-activating protein complex", "d": [], "t": []}], "preferred_name": "snRNA-activating protein complex", "taxa": []} {"type": "biolink:CellularComponent", "ic": "79.928369586049996", "identifiers": [{"i": "GO:0005766", "l": "primary lysosome", "d": ["A lysosome before it has fused with a vesicle or vacuole."], "t": []}], "preferred_name": "primary lysosome", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C1166777", "l": "Intermediate filament cytoskeleton", "d": [], "t": []}], "preferred_name": "Intermediate filament cytoskeleton", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C0230868", "l": "Mitochondrial aggregation within cytoplasm", "d": [], "t": []}, {"i": "SNOMEDCT:46813004", "d": [], "t": []}], "preferred_name": "Mitochondrial aggregation within cytoplasm", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C1325661", "l": "costamere location", "d": [], "t": []}], "preferred_name": "costamere location", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C1325624", "l": "proteasome regulatory particle, base subcomplex", "d": [], "t": []}], "preferred_name": "proteasome regulatory particle, base subcomplex", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C1325682", "l": "43S preribosome", "d": [], "t": []}], "preferred_name": "43S preribosome", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C4690690", "l": "SUMO ligase complex", "d": [], "t": []}], "preferred_name": "SUMO ligase complex", "taxa": []} {"type": "biolink:CellularComponent", "ic": "100", "identifiers": [{"i": "GO:0120106", "l": "mitotic actomyosin contractile ring, distal actin filament layer", "d": ["The region of the mitotic actomyosin ring containing actin filaments and cross linkers, myosin motors, and connections to the plasma membrane through the intermediate layer. It is further from the plasma membrane than the intermediate layer which it is adjacent to."], "t": []}], "preferred_name": "mitotic actomyosin contractile ring, distal actin filament layer", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C1167029", "l": "lytic vacuole within protein storage vacuole", "d": [], "t": []}], "preferred_name": "lytic vacuole within protein storage vacuole", "taxa": []} {"type": "biolink:CellularComponent", "ic": "73.230707576740144", "identifiers": [{"i": "GO:0000502", "l": "proteasome complex", "d": ["A large multisubunit complex which catalyzes protein degradation, found in eukaryotes, archaea and some bacteria. In eukaryotes, this complex consists of the barrel shaped proteasome core complex and one or two associated proteins or complexes that act in regulating entry into or exit from the core."], "t": []}], "preferred_name": "proteasome complex", "taxa": []} {"type": "biolink:CellularComponent", "ic": "87.171193469738924", "identifiers": [{"i": "GO:0031977", "l": "thylakoid lumen", "d": ["The volume enclosed by a thylakoid membrane."], "t": []}], "preferred_name": "thylakoid lumen", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C3893564", "l": "hypotheca", "d": [], "t": []}], "preferred_name": "hypotheca", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C1166868", "l": "Sec34/35 complex", "d": [], "t": []}], "preferred_name": "Sec34/35 complex", "taxa": []} {"type": "biolink:CellularComponent", "ic": "100", "identifiers": [{"i": "GO:0033118", "l": "esterosome membrane", "d": ["The lipid bilayer surrounding an esterosome. 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Mossy fibers enter through all three cerebellar peduncles and send collaterals to the deep cerebellar nuclei, then branch in the white matter and terminate in the granule cell layer. Through this branching, a given mossy fiber can innervate several folia. Mossy fibers synapse on granule cells. The synaptic contacts are made at enlargements along the length of the mossy fiber called mossy fiber rosettes. The enlargements of the rosettes give the axons a mossy-looking appearance in Golgi stained preparations."], "t": []}], "preferred_name": "cerebellar mossy fiber", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C3893291", "l": "phosphatidylinositol 3-kinase complex, class III, type II", "d": [], "t": []}], "preferred_name": "phosphatidylinositol 3-kinase complex, class III, type II", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C1325824", "l": "telomerase RNA location", "d": [], "t": []}], "preferred_name": "telomerase RNA location", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C3158803", "l": "root hair (cell projection)", "d": [], "t": []}], "preferred_name": "root hair (cell projection)", "taxa": []} {"type": "biolink:CellularComponent", "ic": "88.187463028213742", "identifiers": [{"i": "GO:0036056", "l": "filtration diaphragm", "d": ["A specialized cell-cell junction found between the cells of the excretory system, which provides a barrier for filtration of blood or hemolymph."], "t": []}], "preferred_name": "filtration diaphragm", "taxa": []} {"type": "biolink:CellularComponent", "ic": "95.43028691190267", "identifiers": [{"i": "GO:0009329", "l": "acetate CoA-transferase complex", "d": ["A heterotetrameric enzyme complex made up of two alpha subunits and two beta subunits. Part of the acetyl-CoA carboxylase complex. Catalyzes the transfer of a carboxyl group to form malonyl-CoA."], "t": []}], "preferred_name": "acetate CoA-transferase complex", "taxa": []} {"type": "biolink:CellularComponent", "ic": "100", "identifiers": [{"i": "GO:0039670", "l": "viral capsid, turret", "d": ["A turret-like appendage formed at the vertices of an icosahedral capsid."], "t": []}], "preferred_name": "viral capsid, turret", "taxa": []} {"type": "biolink:CellularComponent", "ic": "100", "identifiers": [{"i": "GO:0097408", "l": "fibrillary inclusion", "d": ["Cellular inclusion consisting of circular areas filled with fine slender filaments about 10 nanometers in diameter, delimited by a wall of varying complexity (either a single continuous membrane or a tubular network consisting of a fine filamentous material giving the wall a honeycomb appearance). Fibrillary inclusions are found in the cytoplasm of giant cells of Dieters in the lateral vestibular nucleus of the rat; similar structures have been described in the ventral cochlear nucleus, spinal cord, and substantia nigra."], "t": []}], "preferred_name": "fibrillary inclusion", "taxa": []} {"type": "biolink:CellularComponent", "ic": "100", "identifiers": [{"i": "GO:1990620", "l": "ANPR-A receptor complex", "d": ["A receptor complex composed of two ANPR-A molecules and expressed in the heart atrium in mammals; it plays a major role in the regulation of blood pressure and salt-fluid volume homeostasis. Binding of the ligand AMP in response to atrial distension (high blood volume) leads to guanylate cyclase activity of the ANPR-A receptor complex, thereby elevating intracellular cGMP levels. The end result is a reduction in blood volume and, therefore, a reduction in cardiac output and systemic blood pressure."], "t": []}], "preferred_name": "ANPR-A receptor complex", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C2611072", "l": "synaptotagmin-synaptobrevin 2-SNAP-25-syntaxin-1a-syntaxin-1b-Rab3a-complexin II complex", "d": [], "t": []}], "preferred_name": "synaptotagmin-synaptobrevin 2-SNAP-25-syntaxin-1a-syntaxin-1b-Rab3a-complexin II complex", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C3156650", "l": "box H/ACA scaRNP complex", "d": [], "t": []}], "preferred_name": "box H/ACA scaRNP complex", "taxa": []} {"type": "biolink:CellularComponent", "ic": "95.43028691190267", "identifiers": [{"i": "UMLS:C1521626", "l": "7p21", "d": [], "t": []}, {"i": "NCIT:C25108", "l": "7p21", "d": ["A chromosome band present on 7p"], "t": []}], "preferred_name": "7p21", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C2612370", "l": "preribosome, large subunit precursor", "d": [], "t": []}], "preferred_name": "preribosome, large subunit precursor", "taxa": []} {"type": "biolink:CellularComponent", "ic": "92.757176116311072", "identifiers": [{"i": "GO:0009545", "l": "elaioplast", "d": ["A leucoplast in which oil is stored."], "t": []}], "preferred_name": "elaioplast", "taxa": []} {"type": "biolink:CellularComponent", "ic": "85.51435223262213", "identifiers": [{"i": "GO:0030018", "l": "Z disc", "d": ["Platelike region of a muscle sarcomere to which the plus ends of actin filaments are attached."], "t": []}], "preferred_name": "Z disc", "taxa": []} {"type": "biolink:CellularComponent", "ic": "100", "identifiers": [{"i": "GO:1990508", "l": "CKM complex", "d": ["Cyclin-dependent kinase complex which reversibly associates with the Mediator complex. In Saccharomyces cerevisiae it consists of SSN2, SSN3, SSN8 and SRB8."], "t": []}], "preferred_name": "CKM complex", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C2613149", "l": "FHL2-CREB complex", "d": [], "t": []}], "preferred_name": "FHL2-CREB complex", "taxa": []} {"type": "biolink:CellularComponent", "ic": "84.819741707074996", "identifiers": [{"i": "GO:0015030", "l": "Cajal body", "d": ["A class of nuclear body, first seen after silver staining by Ramon y Cajal in 1903, enriched in small nuclear ribonucleoproteins, and certain general RNA polymerase II transcription factors; ultrastructurally, they appear as a tangle of coiled, electron-dense threads roughly 0.5 micrometers in diameter; involved in aspects of snRNP biogenesis; the protein coilin serves as a marker for Cajal bodies. 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Facilitates the export across the plasma membrane of, amongst others, lipid A and lipopolysaccharide. 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The macropinocytic cup membrane selectively excludes certain proteins, such as H36 or PM4C4 in Dictyostelium, and the underlying cytoskeleton is enriched in F-actin and coronin."], "t": []}], "preferred_name": "macropinocytic cup", "taxa": []} {"type": "biolink:CellularComponent", "ic": "78.031767293544277", "identifiers": [{"i": "GO:0019030", "l": "icosahedral viral capsid", "d": ["The protein coat that surrounds the infective nucleic acid in some virus particles; the subunits are arranged to form an icosahedron, a solid with 20 faces and 12 vertices. Icosahedral capsids have 12 pentamers plus 10(T-1) hexamers, where T is the triangulation number. 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"identifiers": [{"i": "GO:0042564", "l": "NLS-dependent protein nuclear import complex", "d": ["A dimer consisting of an alpha and a beta-subunit that imports proteins with an NLS into the nucleus through a nuclear pore."], "t": []}], "preferred_name": "NLS-dependent protein nuclear import complex", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C3821115", "l": "UvrA(2)-UvrB(2) complex", "d": [], "t": []}], "preferred_name": "UvrA(2)-UvrB(2) complex", "taxa": []} {"type": "biolink:CellularComponent", "ic": "92.757176116311072", "identifiers": [{"i": "UMLS:C1515460", "l": "8q22-q23", "d": [], "t": []}, {"i": "NCIT:C13497", "l": "8q22-q23", "d": ["A chromosome band present on 8q"], "t": []}], "preferred_name": "8q22-q23", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C1622648", "l": "CBF3 complex", "d": [], "t": []}], "preferred_name": "CBF3 complex", "taxa": []} {"type": "biolink:CellularComponent", 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This complex, sometimes called the activated spliceosome, is the catalytically active form of the spliceosome, and includes many proteins in addition to those found in the U2, and U5 and U6 snRNPs."], "t": []}], "preferred_name": "U2-type catalytic step 1 spliceosome", "taxa": []} {"type": "biolink:CellularComponent", "ic": "88.187463028213742", "identifiers": [{"i": "GO:0032154", "l": "cleavage furrow", "d": ["The cleavage furrow is a plasma membrane invagination at the cell division site. 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Mediates the phosphorylation and activation of PKB (also called AKT). In Saccharomyces, the complex contains Avo1p, Avo2p, Tsc11p, Lst8p, Bit61p, Slm1p, Slm2p, and Tor2p."], "t": []}], "preferred_name": "TORC2 complex", "taxa": []} {"type": "biolink:CellularComponent", "ic": "92.757176116311072", "identifiers": [{"i": "GO:0048787", "l": "presynaptic active zone membrane", "d": ["The membrane portion of the presynaptic active zone; it is the site where docking and fusion of synaptic vesicles occurs for the release of neurotransmitters."], "t": []}], "preferred_name": "presynaptic active zone membrane", "taxa": []} {"type": "biolink:CellularComponent", "ic": "100", "identifiers": [{"i": "GO:0070692", "l": "CTDK-1 complex", "d": ["A positive transcription elongation factor complex that comprises the CDK kinase CTK1 (in budding yeast), Lsk1 (in fission yeast) (corresponding to the Panther PTHR24056:SF39 family), a cyclin and an additional gamma subunit (corresponding to the InterPRO entry IPR024638)."], "t": []}], "preferred_name": "CTDK-1 complex", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C1623100", "l": "DNA replication preinitiation complex", "d": [], "t": []}], "preferred_name": "DNA replication preinitiation complex", "taxa": []} {"type": "biolink:CellularComponent", "ic": "95.43028691190267", "identifiers": [{"i": "GO:0010287", "l": "plastoglobule", "d": ["A lipoprotein particle present in chloroplasts. 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The alpha chain is specific to the interleukin-9 receptor, whereas the beta chain is shared with the receptors for several other interleukins."], "t": []}], "preferred_name": "interleukin-9 receptor complex", "taxa": []} {"type": "biolink:CellularComponent", "ic": "100", "identifiers": [{"i": "GO:0097691", "l": "bacterial extracellular vesicle", "d": ["Small membrane vesicle (< 1 um) that buds off a prokaryotic cell plasma membrane, able to carry proteins, phospholipids, lipopolysaccharides, nucleic acids, viruses, and more. Important in intercellular communication and pathogenesis; can exist within host cells."], "t": []}], "preferred_name": "bacterial extracellular vesicle", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C2610709", "l": "cellubrevin-VAMP4-endobrevin-syntaxin-6 complex", "d": [], "t": []}], "preferred_name": "cellubrevin-VAMP4-endobrevin-syntaxin-6 complex", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C2612602", "l": "hydrogenosome lumen", "d": [], "t": []}], "preferred_name": "hydrogenosome lumen", "taxa": []} {"type": "biolink:CellularComponent", "ic": "100", "identifiers": [{"i": "GO:0036488", "l": "CHOP-C/EBP complex", "d": ["A heterodimeric protein complex that is composed of the transcription factor CHOP (GADD153) and a member of the C/EBP family of transcription factors."], "t": []}], "preferred_name": "CHOP-C/EBP complex", "taxa": []} {"type": "biolink:CellularComponent", "ic": "100", "identifiers": [{"i": "GO:0097504", "l": "Gemini of coiled bodies", "d": ["Nuclear bodies frequently found near or associated with Cajal bodies (also called coiled bodies or CBs). 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In addition to fibrillins, microfibrils may contain other associated proteins."], "t": []}], "preferred_name": "microfibril", "taxa": []} {"type": "biolink:CellularComponent", "ic": "89.389454795172327", "identifiers": [{"i": "GO:0033017", "l": "sarcoplasmic reticulum membrane", "d": ["The lipid bilayer surrounding the sarcoplasmic reticulum."], "t": []}], "preferred_name": "sarcoplasmic reticulum membrane", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C3271467", "l": "senescence-associated heterochromatin focus", "d": [], "t": []}], "preferred_name": "senescence-associated heterochromatin focus", "taxa": []} {"type": "biolink:CellularComponent", "ic": "92.757176116311072", "identifiers": [{"i": "GO:1902674", "l": "right posteriolateral basal body", "d": ["Any ciliary basal body that is part of a right posteriolateral flagellum found in Giardia species (trophozoite stage)."], "t": []}], "preferred_name": "right posteriolateral basal body", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C2752281", "l": "Histone Locus Bodies", "d": [], "t": []}], "preferred_name": "Histone Locus Bodies", "taxa": []} {"type": "biolink:CellularComponent", "ic": "100", "identifiers": [{"i": "GO:0043223", "l": "cytoplasmic SCF ubiquitin ligase complex", "d": ["A ubiquitin ligase complex, located in the cytoplasm, in which a cullin from the Cul1 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a Skp1 adaptor and an F-box protein. SCF complexes are involved in targeting proteins for degradation by the proteasome. The best characterized complexes are those from yeast and mammals (with core subunits named Cdc53/Cul1, Rbx1/Hrt1/Roc1)."], "t": []}], "preferred_name": "cytoplasmic SCF ubiquitin ligase complex", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C2754260", "l": "alpha3-beta1 integrin-CD63 complex", "d": [], "t": []}], "preferred_name": "alpha3-beta1 integrin-CD63 complex", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C3546551", "l": "secondary cell wall cellulose synthase complex", "d": [], "t": []}], "preferred_name": "secondary cell wall cellulose synthase complex", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C4690727", "l": "COPII vesicles tethering complex", "d": [], "t": []}], "preferred_name": "COPII vesicles tethering complex", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C1325623", "l": "proteasome regulatory particle (sensu Eukarya) location", "d": [], "t": []}], "preferred_name": "proteasome regulatory particle (sensu Eukarya) location", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C2612908", "l": "Scrib-APC-beta-catenin complex", "d": [], "t": []}], "preferred_name": "Scrib-APC-beta-catenin complex", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C1180313", "l": "Matrix of annulate lamella cistern", "d": [], "t": []}], "preferred_name": "Matrix of annulate lamella cistern", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C2610982", "l": "serum ferritin complex", "d": [], "t": []}], "preferred_name": "serum ferritin complex", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C0230572", "l": "Chromosome group", "d": [], "t": []}, {"i": "SNOMEDCT:90152004", "d": [], "t": []}], "preferred_name": "Chromosome group", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C2753897", "l": "HDA1 complex", "d": [], "t": []}], "preferred_name": "HDA1 complex", "taxa": []} {"type": "biolink:CellularComponent", "ic": "89.389454795172327", "identifiers": [{"i": "UMLS:C1883641", "l": "4p15.32", "d": [], "t": []}, {"i": "NCIT:C67354", "l": "4p15.32", "d": ["A chromosome band present on 4p"], "t": []}], "preferred_name": "4p15.32", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C2325679", "l": "Set of striate nuclei", "d": [], "t": []}], "preferred_name": "Set of striate nuclei", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C2331945", "l": "Set of cytoplasmic organelles of chondrocyte", "d": [], "t": []}], "preferred_name": "Set of cytoplasmic organelles of chondrocyte", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C5450338", "l": "Smc2-Smc4 complex", "d": [], "t": []}], "preferred_name": "Smc2-Smc4 complex", "taxa": []} {"type": "biolink:CellularComponent", "ic": "100", "identifiers": [{"i": "GO:0097453", "l": "mesaxon", "d": ["Portion of the ensheathing process (either myelin or non-myelin) where the enveloping lips of the ensheathing cell come together so that their apposed plasma membranes run parallel to each other, separated by a cleft 12 nm wide."], "t": []}], "preferred_name": "mesaxon", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C1621453", "l": "Swi1-Swi3 complex", "d": [], "t": []}], "preferred_name": "Swi1-Swi3 complex", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C4518052", "l": "Entire nerve fiber", "d": [], "t": []}, {"i": "SNOMEDCT:726785009", "d": [], "t": []}], "preferred_name": "Entire nerve fiber", "taxa": []} {"type": "biolink:CellularComponent", "ic": "100", "identifiers": [{"i": "GO:0071116", "l": "alpha6-beta1 integrin-CYR61 complex", "d": ["A protein complex that consists of an alpha6-beta1 integrin complex bound to CYR61, a cysteine-rich protein involved in angiogenesis."], "t": []}], "preferred_name": "alpha6-beta1 integrin-CYR61 complex", "taxa": []} {"type": "biolink:CellularComponent", "ic": "100", "identifiers": [{"i": "GO:0032783", "l": "super elongation complex", "d": ["A transcription elongation factor complex that increases the overall rate of RNA polymerase II transcription elongation by suppressing transient polymerase pausing. At minimum, the complex contains a transcription factor of the ELL family, an EAF protein, and an AFF family protein or distant relative and most likely also P-TEFb and AF9 or ENL. The complex is conserved from yeast to humans. In Schizosaccharomyces pombe it contains Ell1, Eaf1, and Ebp1, but it is absent from S. cerevisiae."], "t": []}], "preferred_name": "super elongation complex", "taxa": []} {"type": "biolink:CellularComponent", "ic": "100", "identifiers": [{"i": "GO:0071075", "l": "CUGBP1-eIF2 complex", "d": ["A protein complex that contains the eukaryotic translation initiation factor 2 complex (EIF2), CUG binding protein 1, and several endoplasmic reticulum proteins; the complex is involved in the regulation of translation."], "t": []}], "preferred_name": "CUGBP1-eIF2 complex", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C2754251", "l": "CUGBP1-eIF2 complex", "d": [], "t": []}], "preferred_name": "CUGBP1-eIF2 complex", "taxa": []} {"type": "biolink:CellularComponent", "ic": "100", "identifiers": [{"i": "GO:0030869", "l": "RENT complex", "d": ["A protein complex that mediates transcriptional silencing at the rDNA locus (the name derives from regulator of nucleolar silencing and telophase). In Saccharomyces the complex contains Net1p, Sir2p, Cdc14p, and at least one more subunit."], "t": []}], "preferred_name": "RENT complex", "taxa": []} {"type": "biolink:CellularComponent", "ic": "100", "identifiers": [{"i": "GO:0072517", "l": "host cell viral assembly compartment", "d": ["A membrane-bounded compartment that forms in the cytoplasm of the host cell, in which virus assembly takes place."], "t": []}], "preferred_name": "host cell viral assembly compartment", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C1325815", "l": "peripherin location", "d": [], "t": []}], "preferred_name": "peripherin location", "taxa": []} {"type": "biolink:CellularComponent", "ic": "100", "identifiers": [{"i": "GO:0106002", "l": "mCRD-mediated mRNA stability complex", "d": ["A protein complex that binds to, and promotes stabilization of, mRNA molecules containing the major coding region instability determinant (mCRD) by bridging the mCRD domain and the poly(A) tail of the mRNA. 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Ftn is found in most kindoms, while Bfr and Dps are restricted to prokaryotes."], "t": []}], "preferred_name": "ferritin complex", "taxa": []} {"type": "biolink:CellularComponent", "ic": "81.721147647610692", "identifiers": [{"i": "GO:0008076", "l": "voltage-gated potassium channel complex", "d": ["A protein complex that forms a transmembrane channel through which potassium ions may cross a cell membrane in response to changes in membrane potential."], "t": []}], "preferred_name": "voltage-gated potassium channel complex", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C3824492", "l": "receptor-ligand complex", "d": [], "t": []}], "preferred_name": "receptor-ligand complex", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C2325760", "l": "Neuronal receptor", "d": [], "t": []}], "preferred_name": "Neuronal receptor", "taxa": []} {"type": "biolink:CellularComponent", "ic": "95.43028691190267", "identifiers": [{"i": "GO:0031266", "l": "TRAIL death-inducing signaling complex", "d": ["A protein complex formed upon binding of TRAIL to its ligand. 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The host is the larger of the organisms involved in a symbiotic interaction."], "t": []}], "preferred_name": "host cell Cajal body", "taxa": []} {"type": "biolink:CellularComponent", "ic": "84.191390054935425", "identifiers": [{"i": "GO:0071144", "l": "heteromeric SMAD protein complex", "d": ["A protein complex composed of SMAD family proteins, a transcription factor complex which binds to the promoters of target genes and recruits co-activators and histone acetyltransferases, facilitating transcription. Phosphorylation of the non-SMAD4 subunit(s) enables binding of SMAD4 to form heteromeric complexes that enter the nucleus to initiate gene transcription. DNA-binding specificity is conferred by other transcription factors binding to SMAD complexes. Interactions with coactivators or corepressors modulate their transcriptional activity. 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Each AP complex contains two large (a beta and one of either an alpha, gamma, delta, or epsilon) subunits (110-130 kDa), a medium (mu) subunit (approximately 50 kDa), and a small (sigma) subunit (15-20 kDa)."], "t": []}], "preferred_name": "AP-type membrane coat adaptor complex", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C5137280", "l": "DNA topoisomerase III-beta-TDRD3 complex", "d": [], "t": []}], "preferred_name": "DNA topoisomerase III-beta-TDRD3 complex", "taxa": []} {"type": "biolink:CellularComponent", "ic": "100", "identifiers": [{"i": "GO:0120231", "l": "DNA recombinase auxiliary factor complex", "d": ["A protein complex that binds to a recombinase and incrseases its activity."], "t": []}], "preferred_name": "DNA recombinase auxiliary factor complex", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C2755381", "l": "RNA polymerase V complex", "d": [], "t": []}], "preferred_name": "RNA polymerase V complex", "taxa": []} {"type": "biolink:CellularComponent", "ic": "100", "identifiers": [{"i": "GO:0071059", "l": "alpha6-beta1 integrin-CD151 complex", "d": ["A protein complex that consists of an alpha6-beta1 integrin complex bound to the tetraspanin CD151."], "t": []}], "preferred_name": "alpha6-beta1 integrin-CD151 complex", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C3821151", "l": "left anterior flagellum", "d": [], "t": []}], "preferred_name": "left anterior flagellum", "taxa": []} {"type": "biolink:CellularComponent", "ic": "100", "identifiers": [{"i": "GO:0071093", "l": "alpha5-beta1 integrin-fibronectin-tissue transglutaminase complex", "d": ["A protein complex that consists of an alpha5-beta1 integrin complex bound to fibronectin and tissue transglutaminase."], "t": []}], "preferred_name": "alpha5-beta1 integrin-fibronectin-tissue transglutaminase complex", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C2326170", "l": "Set of cytoplasmic organelles of endosteal cell", "d": [], "t": []}], "preferred_name": "Set of cytoplasmic organelles of endosteal cell", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C1718686", "l": "Basement membrane zone BP180", "d": [], "t": []}], "preferred_name": "Basement membrane zone BP180", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C1621476", "l": "invertasome", "d": [], "t": []}], "preferred_name": "invertasome", "taxa": []} {"type": "biolink:CellularComponent", "ic": "100", "identifiers": [{"i": "GO:0000214", "l": "tRNA-intron endonuclease complex", "d": ["A protein complex that catalyzes the endonucleolytic cleavage of pre-tRNA, producing 5'-hydroxyl and 2',3'-cyclic phosphate termini, and specifically removing the intron."], "t": []}], "preferred_name": "tRNA-intron endonuclease complex", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C1527278", "l": "provirus location", "d": [], "t": []}], "preferred_name": "provirus location", "taxa": []} {"type": "biolink:CellularComponent", "ic": "100", "identifiers": [{"i": "GO:0071758", "l": "IgW immunoglobulin complex", "d": ["A protein complex composed of two identical immunoglobulin heavy chains of the IgW isotype and two identical immunoglobulin light chains, held together by disulfide bonds. An IgW immunoglobulin complex may be embedded in the plasma membrane or present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph."], "t": []}], "preferred_name": "IgW immunoglobulin complex", "taxa": []} {"type": "biolink:CellularComponent", "ic": "100", "identifiers": [{"i": "GO:1990902", "l": "new cell pole", "d": ["The cell pole proximal to the most recent cell division."], "t": []}], "preferred_name": "new cell pole", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C0230533", "l": "Anaphase nucleus", "d": [], "t": []}, {"i": "SNOMEDCT:11219001", "d": [], "t": []}], "preferred_name": "Anaphase nucleus", "taxa": []} {"type": "biolink:CellularComponent", "ic": "92.757176116311072", "identifiers": [{"i": "GO:0005802", "l": "trans-Golgi network", "d": ["The network of interconnected tubular and cisternal structures located within the Golgi apparatus on the side distal to the endoplasmic reticulum, from which secretory vesicles emerge. The trans-Golgi network is important in the later stages of protein secretion where it is thought to play a key role in the sorting and targeting of secreted proteins to the correct destination."], "t": []}], "preferred_name": "trans-Golgi network", "taxa": []} {"type": "biolink:CellularComponent", "ic": "100", "identifiers": [{"i": "GO:0110016", "l": "B-WICH complex", "d": ["A chromatin remodeling complex that positively regulates histone H3 acetylation, in particular H3K9, by recruiting histone acetyltransferases to rDNA gene regions. Located in the nucleolus where it assembles on RNA Polymerase I (Pol I) and possibly on RNA Polymerase III (Pol III) promoter and coding regions during early G1 phase and activates the post-initiation phases of Pol I transcription. May also activate RNA Polymerase II (Pol II) gene transcription. In mammals, B-WICH contains the WICH complex core of BAZ1B and SMARCA5, additional protein subunits and possibly rRNAs. Although it contains several catalytic subunits it is not clear which functions are carried out by the complex itself."], "t": []}], "preferred_name": "B-WICH complex", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C5451461", "l": "autolysosome lumen", "d": [], "t": []}], "preferred_name": "autolysosome lumen", "taxa": []} {"type": "biolink:CellularComponent", "ic": "100", "identifiers": [{"i": "GO:0106055", "l": "mannosyl-oligosaccharide 1,2-alpha-mannosidase complex", "d": ["A protein complex capable of catalysing the hydrolysis of the terminal (1->2)-linked alpha-D-mannose residues in an oligo-mannose oligosaccharide."], "t": []}], "preferred_name": "mannosyl-oligosaccharide 1,2-alpha-mannosidase complex", "taxa": []} {"type": "biolink:CellularComponent", "ic": "89.389454795172327", "identifiers": [{"i": "GO:0022627", "l": "cytosolic small ribosomal subunit", "d": ["The small subunit of a ribosome located in the cytosol."], "t": []}], "preferred_name": "cytosolic small ribosomal subunit", "taxa": []} {"type": "biolink:CellularComponent", "ic": "65.691532569937081", "identifiers": [{"i": "GO:0098687", "l": "chromosomal region", "d": ["Any subdivision of a chromosome along its length."], "t": []}], "preferred_name": "chromosomal region", "taxa": []} {"type": "biolink:CellularComponent", "ic": "95.43028691190267", "identifiers": [{"i": "GO:0036501", "l": "UFD1-NPL4 complex", "d": ["A dimeric protein complex that contains the co-factors for the ATPase VCP/p97 (Cdc48p in budding yeast). In mammals, this complex consists of UFD1L (UFD1) and NPLOC4 (NPL4). In budding yeast, the complex is a dimer of Ufd1p and Npl4p."], "t": []}], "preferred_name": "UFD1-NPL4 complex", "taxa": []} {"type": "biolink:CellularComponent", "ic": "83.617749940116425", "identifiers": [{"i": "GO:0045171", "l": "intercellular bridge", "d": ["A direct connection between the cytoplasm of two cells that is formed following the completion of cleavage furrow ingression during cell division. They are usually present only briefly prior to completion of cytokinesis. However, in some cases, such as the bridges between germ cells during their development, they become stabilised."], "t": []}], "preferred_name": "intercellular bridge", "taxa": []} {"type": "biolink:CellularComponent", "ic": "100", "identifiers": [{"i": "GO:0097221", "l": "M/G1 phase-specific MADS box-forkhead transcription factor complex", "d": ["A protein complex that contains a MADS-box protein and two forkhead domain proteins, and binds to and regulates transcription from promoters of genes transcribed during the M/G1 transition of the cell cycle. In Schizosaccharomyces pombe, the complex contains the MADS-box protein Mbx1 and two forkhead proteins, Sep1 and Fkh2."], "t": []}], "preferred_name": "M/G1 phase-specific MADS box-forkhead transcription factor complex", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C2612833", "l": "integrin alphaE-beta7 complex", "d": [], "t": []}], "preferred_name": "integrin alphaE-beta7 complex", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C1167170", "l": "U6 snRNP location", "d": [], "t": []}], "preferred_name": "U6 snRNP location", "taxa": []} {"type": "biolink:CellularComponent", "ic": "92.757176116311072", "identifiers": [{"i": "UMLS:C1521417", "l": "4q34-q35", "d": [], "t": []}, {"i": "NCIT:C13512", "l": "4q34-q35", "d": ["A chromosome band present on 4q"], "t": []}], "preferred_name": "4q34-q35", "taxa": []} {"type": "biolink:CellularComponent", "ic": "95.43028691190267", "identifiers": [{"i": "GO:0097511", "l": "dendritic cell dendrite", "d": ["A branched cellular projection (or cytoplasmic extension) that is extended from the surface of a dendritic immune cell, and which enables the cell to sample luminal pathogens and increase the surface area for antigen presentation to T cells."], "t": []}], "preferred_name": "dendritic cell dendrite", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C3271738", "l": "large latent transforming growth factor-beta complex", "d": [], "t": []}], "preferred_name": "large latent transforming growth factor-beta complex", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C3541837", "l": "pre-synaptic ribbon", "d": [], "t": []}], "preferred_name": "pre-synaptic ribbon", "taxa": []} {"type": "biolink:CellularComponent", "ic": "100", "identifiers": [{"i": "GO:0048493", "l": "plasma membrane-derived thylakoid ribulose bisphosphate carboxylase complex", "d": ["A complex, located in the plasma membrane-derived thylakoid, containing either both large and small subunits or just small subunits. It carries out the activity of producing 3-phosphoglycerate from carbon dioxide and ribulose-1,5-bisphosphate."], "t": []}], "preferred_name": "plasma membrane-derived thylakoid ribulose bisphosphate carboxylase complex", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C2754208", "l": "alpha9-beta1 integrin-ADAM1 complex", "d": [], "t": []}], "preferred_name": "alpha9-beta1 integrin-ADAM1 complex", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C5137206", "l": "shmoo tip membrane", "d": [], "t": []}], "preferred_name": "shmoo tip membrane", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C1179072", "l": "Luminal component of nuclear pore complex", "d": [], "t": []}], "preferred_name": "Luminal component of nuclear pore complex", "taxa": []} {"type": "biolink:CellularComponent", "ic": "90.860573823805353", "identifiers": [{"i": "UMLS:C1520494", "l": "12q13.1", "d": [], "t": []}, {"i": "NCIT:C13848", "l": "12q13.1", "d": ["A chromosome band present on 12q"], "t": []}], "preferred_name": "12q13.1", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C2755002", "l": "IgW immunoglobulin complex", "d": [], "t": []}], "preferred_name": "IgW immunoglobulin complex", "taxa": []} {"type": "biolink:CellularComponent", "ic": "100", "identifiers": [{"i": "GO:0030232", "l": "insulin control element activator complex", "d": ["Transcription factor complex that binds to the insulin control element (ICE), a DNA sequence element found within the 5'-flanking region of the insulin gene, and activates ICE-mediated transcription."], "t": []}], "preferred_name": "insulin control element activator complex", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C3896402", "l": "Bud14-Kel1-Kel2 complex", "d": [], "t": []}], "preferred_name": "Bud14-Kel1-Kel2 complex", "taxa": []} {"type": "biolink:CellularComponent", "ic": "95.43028691190267", "identifiers": [{"i": "GO:0008091", "l": "spectrin", "d": ["Membrane associated dimeric protein (240 and 220 kDa) of erythrocytes. Forms a complex with ankyrin, actin and probably other components of the membrane cytoskeleton, so that there is a mesh of proteins underlying the plasma membrane, potentially restricting the lateral mobility of integral proteins."], "t": []}], "preferred_name": "spectrin", "taxa": []} {"type": "biolink:CellularComponent", "ic": "95.43028691190267", "identifiers": [{"i": "GO:0098733", "l": "hemidesmosome associated protein complex", "d": ["Any protein complex that is part of or has some part in a hemidesmosome."], "t": []}], "preferred_name": "hemidesmosome associated protein complex", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C3548427", "l": "mitotic spindle pole", "d": [], "t": []}], "preferred_name": "mitotic spindle pole", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C2266172", "l": "main terminal branch", "d": [], "t": []}], "preferred_name": "main terminal branch", "taxa": []} {"type": "biolink:CellularComponent", "ic": "100", "identifiers": [{"i": "GO:0106391", "l": "bI4 intron splicing complex", "d": ["A protein complex required for the splicing of intron 4 of the cytochrome b (COB) gene. In S. cerevisiae, the complex contains the maturase bI4 (which derives from one of the products of the splicing), Leucyl-tRNA synthetase NAM2 and the intron 4 of the cytochrome b pre-mRNA. The two proteins stimulate the ribozyme activity of the pre-mRNA which autoctalyse a group I intron splicing."], "t": []}], "preferred_name": "bI4 intron splicing complex", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C1166641", "l": "bacterial-type flagellum hook-filament junction", "d": [], "t": []}], "preferred_name": "bacterial-type flagellum hook-filament junction", "taxa": []} {"type": "biolink:CellularComponent", "ic": "85.51435223262213", "identifiers": [{"i": "UMLS:C1521067", "l": "20q13.3", "d": [], "t": []}, {"i": "NCIT:C13756", "l": "20q13.3", "d": ["A chromosome band present on 20q"], "t": []}], "preferred_name": "20q13.3", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C5445059", "l": "dynein axonemal particle", "d": [], "t": []}], "preferred_name": "dynein axonemal particle", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C2754970", "l": "IgD B cell receptor complex", "d": [], "t": []}], "preferred_name": "IgD B cell receptor complex", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C1180336", "l": "Part of annulate lamella", "d": [], "t": []}], "preferred_name": "Part of annulate lamella", "taxa": []} {"type": "biolink:CellularComponent", "ic": "100", "identifiers": [{"i": "UMLS:C1711287", "l": "3q23-q24", "d": [], "t": []}, {"i": "NCIT:C45201", "l": "3q23-q24", "d": ["A chromosome band present on 3q"], "t": []}], "preferred_name": "3q23-q24", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C3893561", "l": "dinoflagellate hypocone", "d": [], "t": []}], "preferred_name": "dinoflagellate hypocone", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C3895356", "l": "sigma factor antagonist complex", "d": [], "t": []}], "preferred_name": "sigma factor antagonist complex", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C1166744", "l": "ER to Golgi transport vesicle membrane", "d": [], "t": []}], "preferred_name": "ER to Golgi transport vesicle membrane", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C3821282", "l": "methyl accepting chemotaxis protein complex", "d": [], "t": []}], "preferred_name": "methyl accepting chemotaxis protein complex", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C2612810", "l": "ITGA9-ITGB1 complex", "d": [], "t": []}], "preferred_name": "ITGA9-ITGB1 complex", "taxa": []} {"type": "biolink:CellularComponent", "ic": "90.860573823805353", "identifiers": [{"i": "GO:0016222", "l": "procollagen-proline 4-dioxygenase complex", "d": ["A protein complex that catalyzes the formation of procollagen trans-4-hydroxy-L-proline and succinate from procollagen L-proline and 2-oxoglutarate, requiring Fe2+ and ascorbate. Contains two alpha subunits that contribute to most parts of the catalytic sites, and two beta subunits that are identical to protein-disulfide isomerase."], "t": []}], "preferred_name": "procollagen-proline 4-dioxygenase complex", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C4323129", "l": "Cell body proper of photoreceptor", "d": [], "t": []}], "preferred_name": "Cell body proper of photoreceptor", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C0596119", "l": "apical membrane", "d": [], "t": []}], "preferred_name": "apical membrane", "taxa": []} {"type": "biolink:CellularComponent", "ic": "100", "identifiers": [{"i": "GO:0070913", "l": "Ddb1-Wdr21 complex", "d": ["A heterodimeric nucleotide-excision repair complex that is involved in transcription-coupled repair. The subunits are known as Ddb1 and Wdr21 in S. pombe; Ddb1 contains a motif called the DDB-box that interacts with adaptor proteins for DDB1/cullin 4 ubiquitin ligases."], "t": []}], "preferred_name": "Ddb1-Wdr21 complex", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C1179054", "l": "External fiber of cone cell", "d": [], "t": []}], "preferred_name": "External fiber of cone cell", "taxa": []} {"type": "biolink:CellularComponent", "ic": "95.43028691190267", "identifiers": [{"i": "GO:0012511", "l": "monolayer-surrounded lipid storage body", "d": ["A subcellular organelle of plant cells surrounded by 'half-unit' or a monolayer membrane instead of the more usual bilayer. The storage body has a droplet of triglyceride surrounded by a monolayer of phospholipids, interacting with the triglycerides and the hydrophilic head groups facing the cytosol, and containing major protein components called oleosins."], "t": []}], "preferred_name": "monolayer-surrounded lipid storage body", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C3156614", "l": "NLRP3 inflammasome complex", "d": [], "t": []}], "preferred_name": "NLRP3 inflammasome complex", "taxa": []} {"type": "biolink:CellularComponent", "ic": "100", "identifiers": [{"i": "GO:1990159", "l": "DnaB-DnaC-DnaT-PriA-PriC complex", "d": ["A protein-DNA complex consisting of the helicase loading complex DnaB-DnaC, replication restart proteins DnaT, PriA and PriC, and associated DNA. Involved in the restart of DNA replication after a stalled replication fork has been repaired."], "t": []}], "preferred_name": "DnaB-DnaC-DnaT-PriA-PriC complex", "taxa": []} {"type": "biolink:CellularComponent", "ic": "100", "identifiers": [{"i": "GO:0031615", "l": "cytosolic proteasome regulatory particle, lid subcomplex", "d": ["The subcomplex of the cytosolic proteasome regulatory particle that forms the peripheral lid, which is added on top of the base subcomplex."], "t": []}], "preferred_name": "cytosolic proteasome regulatory particle, lid subcomplex", "taxa": []} {"type": "biolink:CellularComponent", "ic": "100", "identifiers": [{"i": "GO:0120513", "l": "2-(3-amino-3-carboxypropyl)histidine synthase complex", "d": ["A protein complex capable of catalysing the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L-methionine (SAM) to the histidine residue of translation elongation factor 2 (EF2), which is the first step in the biosynthesis of diphthamide. The complex is a Dph2 homodimer in archaea and a Dph1-Dph2 heterodimer in eukaryotes."], "t": []}], "preferred_name": "2-(3-amino-3-carboxypropyl)histidine synthase complex", "taxa": []} {"type": "biolink:CellularComponent", "ic": "100", "identifiers": [{"i": "UMLS:C1520198", "l": "Xq26.3-q27.1", "d": [], "t": []}, {"i": "NCIT:C13582", "l": "Xq26.3-q27.1", "d": ["A chromosome band present on Xq"], "t": []}], "preferred_name": "Xq26.3-q27.1", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "MESH:D022201", "l": "Chromosomes, Artificial", "d": [], "t": []}], "preferred_name": "Chromosomes, Artificial", "taxa": []} {"type": "biolink:CellularComponent", "ic": "100", "identifiers": [{"i": "GO:1990780", "l": "cytoplasmic side of dendritic spine plasma membrane", "d": ["The leaflet of the plasma membrane that faces the cytoplasm and any proteins embedded or anchored in it or attached to its surface surrounding a dendritic spine."], "t": []}], "preferred_name": "cytoplasmic side of dendritic spine plasma membrane", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C5379848", "l": "ELL-EAF-EBP complex", "d": [], "t": []}], "preferred_name": "ELL-EAF-EBP complex", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C2754283", "l": "ITGA3-ITGB1-TGM2 complex", "d": [], "t": []}], "preferred_name": "ITGA3-ITGB1-TGM2 complex", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C2754109", "l": "mammalian U2-type spliceosomal complex A", "d": [], "t": []}], "preferred_name": "mammalian U2-type spliceosomal complex A", "taxa": []} {"type": "biolink:CellularComponent", "ic": "90.860573823805353", "identifiers": [{"i": "UMLS:C1521702", "l": "8p21.1", "d": [], "t": []}, {"i": "NCIT:C25119", "l": "8p21.1", "d": ["A chromosome band present on 8p"], "t": []}], "preferred_name": "8p21.1", "taxa": []} {"type": "biolink:CellularComponent", "ic": "100", "identifiers": [{"i": "GO:0061574", "l": "ASAP complex", "d": ["A protein complex involved in regulation of mRNA processing and apoptosis. It binds to RNA in a sequence-independent manner and is recruited to the EJC prior to or during the splicing process. In humans the core proteins are RNPS1, SAP18 and ACIN1."], "t": []}], "preferred_name": "ASAP complex", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C4235091", "l": "PET complex", "d": [], "t": []}], "preferred_name": "PET complex", "taxa": []} {"type": "biolink:CellularComponent", "ic": "79.328619724587128", "identifiers": [{"i": "UMLS:C1515472", "l": "8q24.3", "d": [], "t": []}, {"i": "NCIT:C14026", "l": "8q24.3", "d": ["A chromosome band present on 8q"], "t": []}], "preferred_name": "8q24.3", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C2755001", "l": "hexameric IgM immunoglobulin complex", "d": [], "t": []}], "preferred_name": "hexameric IgM immunoglobulin complex", "taxa": []} {"type": "biolink:CellularComponent", "ic": "92.757176116311072", "identifiers": [{"i": "GO:0043493", "l": "viral terminase complex", "d": ["A complex of a large and small subunit which catalyze the packaging of DNA into viral heads. 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The ribbon's surface is studded with small particles to which synaptic vesicles tether via fine filaments. The tethered vesicles function as a pool, several fold greater than the docked pool available for fast release, which supports sustained release of vesicles. 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Chromosome 17 spans more than 81 million base pairs and represents between 2.5 and 3% of the total DNA in normal diploid cells."], "t": []}, {"i": "SNOMEDCT:45201007", "d": [], "t": []}], "preferred_name": "Chromosomes, Human, Pair 17", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C3822522", "l": "ThiF-ThiS complex", "d": [], "t": []}], "preferred_name": "ThiF-ThiS complex", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C1166793", "l": "minus-end kinesin complex", "d": [], "t": []}], "preferred_name": "minus-end kinesin complex", "taxa": []} {"type": "biolink:CellularComponent", "ic": "100", "identifiers": [{"i": "GO:0098550", "l": "lumenal side of early endosome membrane", "d": ["The side (leaflet) of the early endosome membrane that faces the lumen."], "t": []}], "preferred_name": "lumenal side of early endosome membrane", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C1523859", "l": "lateral loop", "d": [], "t": []}], "preferred_name": "lateral loop", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C1325666", "l": "chromoplast membrane", "d": [], "t": []}], "preferred_name": "chromoplast membrane", "taxa": []} {"type": "biolink:CellularComponent", "ic": "100", "identifiers": [{"i": "GO:0070721", "l": "ISGF3 complex", "d": ["A transcription factor complex that consists of a Stat1-Stat2 heterodimer and the IRF9 protein."], "t": []}], "preferred_name": "ISGF3 complex", "taxa": []} {"type": "biolink:CellularComponent", "ic": "100", "identifiers": [{"i": "GO:0120155", "l": "MIH complex", "d": ["A trimeric complex involved in cytokinesis. Proposed to bridge actomyosin ring contraction and septum synthesis in yeast, resulting in the coordination of these processes, and leading to plasma membrane ingression and fusion. In the yeast Saccharomyces cerevisiae this complex consists of Mlc1p, Iqg1p and Hof1p proteins."], "t": []}], "preferred_name": "MIH complex", "taxa": []} {"type": "biolink:CellularComponent", "ic": "100", "identifiers": [{"i": "GO:0140472", "l": "cell cortex of non-growing cell tip", "d": ["The region directly beneath the plasma membrane at the cell tip at which no growth takes place."], "t": []}], "preferred_name": "cell cortex of non-growing cell tip", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C3823016", "l": "right ventral basal body", "d": [], "t": []}], "preferred_name": "right ventral basal body", "taxa": []} {"type": "biolink:CellularComponent", "ic": "100", "identifiers": [{"i": "GO:0036411", "l": "H-NS-Cnu complex", "d": ["A trimeric protein complex containing a H-NS homodimer and a Cnu monomer. 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In response to the arrival of action potentials, the presynaptic button releases molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane of the muscle fiber, leading to a change in post-synaptic potential that inhibits muscle contraction."], "t": []}], "preferred_name": "inhibitory neuromuscular junction", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C2754162", "l": "mammalian U12-type spliceosomal complex C", "d": [], "t": []}], "preferred_name": "mammalian U12-type spliceosomal complex C", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C4329065", "l": "growth cone leading edge", "d": [], "t": []}], "preferred_name": "growth cone leading edge", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C1167492", "l": "protein kinase CK2 complex", "d": [], "t": []}], "preferred_name": "protein kinase CK2 complex", "taxa": []} {"type": "biolink:CellularComponent", "ic": "62.828005580323079", "identifiers": [{"i": "GO:0098588", "l": "bounding membrane of organelle", "d": ["The lipid bilayer that forms the outer-most layer of an organelle."], "t": []}], "preferred_name": "bounding membrane of organelle", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C2329701", "l": "Set of nuclei of neuraxis", "d": [], "t": []}], "preferred_name": "Set of nuclei of neuraxis", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C1744674", "l": "RNA polymerase I upstream activating factor complex location", "d": [], "t": []}], "preferred_name": "RNA polymerase I upstream activating factor complex location", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C2612905", "l": "Par3-APC-KIF3A complex", "d": [], "t": []}], "preferred_name": "Par3-APC-KIF3A complex", "taxa": []} {"type": "biolink:CellularComponent", "ic": "100", "identifiers": [{"i": "GO:0034709", "l": "methylosome", "d": ["A large (20 S) protein complex that possesses protein arginine methyltransferase activity and modifies specific arginines to dimethylarginines in the arginine- and glycine-rich domains of several spliceosomal Sm proteins, thereby targeting these proteins to the survival of motor neurons (SMN) complex for assembly into small nuclear ribonucleoprotein (snRNP) core particles. Proteins found in the methylosome include the methyltransferase JBP1 (PRMT5), pICln (CLNS1A), MEP50 (WDR77), and unmethylated forms of SM proteins that have RG domains."], "t": []}], "preferred_name": "methylosome", "taxa": []} {"type": "biolink:CellularComponent", "ic": "100", "identifiers": [{"i": "GO:0140022", "l": "cnida", "d": ["A giant secretory organelle that comprises a bulb-shape capsule containing a coiled hollow tubule structure attached to it. A cnida defines the phylum Cnidaria."], "t": []}], "preferred_name": "cnida", "taxa": []} {"type": "biolink:CellularComponent", "ic": "90.860573823805353", "identifiers": [{"i": "UMLS:C2825971", "l": "7q32.2", "d": [], "t": []}, {"i": "NCIT:C82116", "l": "7q32.2", "d": ["A chromosome band present on 7q."], "t": []}], "preferred_name": "7q32.2", "taxa": []} {"type": "biolink:CellularComponent", "ic": "100", "identifiers": [{"i": "GO:0044317", "l": "rod spherule", "d": ["A specialized neuron projection which is the site of synaptic transmission produced by retinal rod cells. Rod spherules are small round enlargements of the axon (3-5 micrometers diameter) or even extensions of the cell body."], "t": []}], "preferred_name": "rod spherule", "taxa": []} {"type": "biolink:CellularComponent", "ic": "100", "identifiers": [{"i": "NCIT:C13554", "l": "22p", "d": ["Proximal (short) arm of chromosome 22"], "t": []}], "preferred_name": "22p", "taxa": []} {"type": "biolink:CellularComponent", "ic": "84.819741707074996", "identifiers": [{"i": "GO:0030666", "l": "endocytic vesicle membrane", "d": ["The lipid bilayer surrounding an endocytic vesicle."], "t": []}], "preferred_name": "endocytic vesicle membrane", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C4329069", "l": "dendritic spine cytoplasm", "d": [], "t": []}], "preferred_name": "dendritic spine cytoplasm", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C2331603", "l": "Plasma membrane of Type K enteroendocrine cell", "d": [], "t": []}], "preferred_name": "Plasma membrane of Type K enteroendocrine cell", "taxa": []} {"type": "biolink:CellularComponent", "ic": "92.757176116311072", "identifiers": [{"i": "GO:0032158", "l": "septin band", "d": ["A diffuse ring composed of a series of septin bars that run parallel to the long axis of the cell. This type of septin structure has been observed in a number of locations associated with polarized grown and/or deposition of new membrane, but not with cytokinesis, such as at the shmoo (mating projection) neck, at the junction between the mother cell and the germ tube (hypha) of a fungal cell growing filamentously."], "t": []}], "preferred_name": "septin band", "taxa": []} {"type": "biolink:CellularComponent", "ic": "90.860573823805353", "identifiers": [{"i": "UMLS:C1710907", "l": "1q24.2", "d": [], "t": []}, {"i": "NCIT:C54558", "l": "1q24.2", "d": ["A chromosome band present on 1q"], "t": []}], "preferred_name": "1q24.2", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C2752460", "l": "host cell endoplasmic reticulum membrane", "d": [], "t": []}], "preferred_name": "host cell endoplasmic reticulum membrane", "taxa": []} {"type": "biolink:CellularComponent", "ic": "95.43028691190267", "identifiers": [{"i": "GO:0016606", "l": "LYSP100-associated nuclear domain", "d": ["A nuclear body that is enriched in the lymphoid cell-specific protein LYSp100B; LANDs are globular, electron-dense structures and are morphologically distinct from the annular structures characteristic of PML bodies."], "t": []}], "preferred_name": "LYSP100-associated nuclear domain", "taxa": []} {"type": "biolink:CellularComponent", "ic": "86.290860735708023", "identifiers": [{"i": "UMLS:C1520787", "l": "17q24.2", "d": [], "t": []}, {"i": "NCIT:C30155", "l": "17q24.2", "d": ["A chromosome band present on 17q"], "t": []}], "preferred_name": "17q24.2", "taxa": []} {"type": "biolink:CellularComponent", "ic": "77.36074427942161", "identifiers": [{"i": "GO:0044306", "l": "neuron projection terminus", "d": ["The specialized, terminal region of a neuron projection such as an axon or a dendrite."], "t": []}], "preferred_name": "neuron projection terminus", "taxa": []} {"type": "biolink:CellularComponent", "ic": "70.189193548392481", "identifiers": [{"i": "GO:0005654", "l": "nucleoplasm", "d": ["That part of the nuclear content other than the chromosomes or the nucleolus."], "t": []}], "preferred_name": "nucleoplasm", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C3896460", "l": "S100A8 complex", "d": [], "t": []}], "preferred_name": "S100A8 complex", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C1752771", "l": "exospore", "d": [], "t": []}], "preferred_name": "exospore", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C1167334", "l": "mating projection", "d": [], "t": []}], "preferred_name": "mating projection", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C4328919", "l": "extrinsic component of presynaptic membrane", "d": [], "t": []}], "preferred_name": "extrinsic component of presynaptic membrane", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C2754240", "l": "alpha4-beta1 integrin-thrombospondin-1 complex", "d": [], "t": []}], "preferred_name": "alpha4-beta1 integrin-thrombospondin-1 complex", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C1622034", "l": "extrinsic component of endosome membrane", "d": [], "t": []}], "preferred_name": "extrinsic component of endosome membrane", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C1523863", "l": "nuclear SCF ubiquitin ligase complex", "d": [], "t": []}], "preferred_name": "nuclear SCF ubiquitin ligase complex", "taxa": []} {"type": "biolink:CellularComponent", "ic": "95.43028691190267", "identifiers": [{"i": "GO:1990021", "l": "Schaffer axon collateral", "d": ["Part of axon of a CA3 pyramidal neuron that projects to hippocampal area CA1."], "t": []}], "preferred_name": "Schaffer axon collateral", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C0230755", "l": "Central pair of microtubules, cilium or flagellum, not bacterial", "d": [], "t": []}, {"i": "SNOMEDCT:149003", "d": [], "t": []}], "preferred_name": "Central pair of microtubules, cilium or flagellum, not bacterial", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C4326936", "l": "CATCHR family complex", "d": [], "t": []}], "preferred_name": "CATCHR family complex", "taxa": []} {"type": "biolink:CellularComponent", "ic": "90.860573823805353", "identifiers": [{"i": "UMLS:C1520265", "l": "10p15.1", "d": [], "t": []}, {"i": "NCIT:C13789", "l": "10p15.1", "d": ["A chromosome band present on 10p"], "t": []}], "preferred_name": "10p15.1", "taxa": []} {"type": "biolink:CellularComponent", "ic": "89.389454795172327", "identifiers": [{"i": "UMLS:C1520473", "l": "12p12.3", "d": [], "t": []}, {"i": "NCIT:C13706", "l": "12p12.3", "d": ["A chromosome band present on 12p"], "t": []}], "preferred_name": "12p12.3", "taxa": []} {"type": "biolink:CellularComponent", "ic": "77.36074427942161", "identifiers": [{"i": "GO:0043197", "l": "dendritic spine", "d": ["A small, membranous protrusion from a dendrite that forms a postsynaptic compartment, typically receiving input from a single presynapse. They function as partially isolated biochemical and an electrical compartments. Spine morphology is variable:they can be thin, stubby, mushroom, or branched, with a continuum of intermediate morphologies. They typically terminate in a bulb shape, linked to the dendritic shaft by a restriction. Spine remodeling is though to be involved in synaptic plasticity."], "t": []}], "preferred_name": "dendritic spine", "taxa": []} {"type": "biolink:CellularComponent", "ic": "100", "identifiers": [{"i": "GO:0010005", "l": "cortical microtubule, transverse to long axis", "d": ["Arrays of microtubules underlying and connected to the plasma membrane, in the cortical cytosol, oriented mainly with their axes transverse to the long axis of the cell (and root in plants). In plants it influences the direction of cellulose microfibril deposition."], "t": []}], "preferred_name": "cortical microtubule, transverse to long axis", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C1167124", "l": "MCM complex", "d": [], "t": []}], "preferred_name": "MCM complex", "taxa": []} {"type": "biolink:CellularComponent", "ic": "86.290860735708023", "identifiers": [{"i": "UMLS:C1520481", "l": "12p13.3", "d": [], "t": []}, {"i": "NCIT:C28484", "l": "12p13.3", "d": ["A chromosome band present on 12p"], "t": []}], "preferred_name": "12p13.3", "taxa": []} {"type": "biolink:CellularComponent", "ic": "100", "identifiers": [{"i": "GO:1990131", "l": "Gtr1-Gtr2 GTPase complex", "d": ["A heterodimer GTPase complex. In S. cerevisiae, this complex contains Gtr1p and Gtr2p proteins."], "t": []}], "preferred_name": "Gtr1-Gtr2 GTPase complex", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C1325676", "l": "Nucleolar preribosome", "d": [], "t": []}], "preferred_name": "Nucleolar preribosome", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C3546212", "l": "bacteriophage tail tube", "d": [], "t": []}], "preferred_name": "bacteriophage tail tube", "taxa": []} {"type": "biolink:CellularComponent", "ic": "83.090052188295473", "identifiers": [{"i": "GO:0060198", "l": "clathrin-sculpted vesicle", "d": ["A clathrin-sculpted lipid bilayer membrane-enclosed vesicle after clathrin release."], "t": []}], "preferred_name": "clathrin-sculpted vesicle", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "MESH:D021961", "l": "Cell Membrane Structures", "d": [], "t": []}, {"i": "UMLS:C0887867", "l": "Cell Membrane Structures", "d": [], "t": []}, {"i": "SNOMEDCT:312241000", "d": [], "t": []}], "preferred_name": "Cell Membrane Structures", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C3821058", "l": "necrosome", "d": [], "t": []}], "preferred_name": "necrosome", "taxa": []} {"type": "biolink:CellularComponent", "ic": "100", "identifiers": [{"i": "GO:0044218", "l": "other organism cell membrane", "d": ["The cell membrane of a secondary organism with which the first organism is interacting."], "t": []}], "preferred_name": "other organism cell membrane", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C4690184", "l": "collagen-containing extracellular matrix", "d": [], "t": []}], "preferred_name": "collagen-containing extracellular matrix", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C4690289", "l": "HCN4 channel complex", "d": [], "t": []}], "preferred_name": "HCN4 channel complex", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C1656978", "l": "cell tip", "d": [], "t": []}], "preferred_name": "cell tip", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C1820105", "l": "EKC/KEOPS complex", "d": [], "t": []}], "preferred_name": "EKC/KEOPS complex", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C5379989", "l": "hyphae septin collar", "d": [], "t": []}], "preferred_name": "hyphae septin collar", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C1166932", "l": "cytosolic oxoglutarate dehydrogenase complex", "d": [], "t": []}], "preferred_name": "cytosolic oxoglutarate dehydrogenase complex", "taxa": []} {"type": "biolink:CellularComponent", "ic": "100", "identifiers": [{"i": "GO:0034692", "l": "E.F.G complex", "d": ["A protein complex that comprises three core spliceosomal proteins, designated E, F, and G. Formation of the E.F.G complex is essential but not sufficient for the formation of a stable U1 snRNP complex."], "t": []}], "preferred_name": "E.F.G complex", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C5450346", "l": "gamma-tubulin ring complex, centrosomal", "d": [], "t": []}], "preferred_name": "gamma-tubulin ring complex, centrosomal", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C3896155", "l": "Cus cation efflux complex", "d": [], "t": []}], "preferred_name": "Cus cation efflux complex", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C0230761", "l": "Fibrous sheath of spermatozoa tail", "d": [], "t": []}, {"i": "SNOMEDCT:14167003", "d": [], "t": []}], "preferred_name": "Fibrous sheath of spermatozoa tail", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C2753440", "l": "macropinocytic cup cytoskeleton", "d": [], "t": []}], "preferred_name": "macropinocytic cup cytoskeleton", "taxa": []} {"type": "biolink:CellularComponent", "ic": "80.25002861897768", "identifiers": [{"i": "UMLS:C1521285", "l": "3p21.3", "d": [], "t": []}, {"i": "NCIT:C13471", "l": "3p21.3", "d": ["A chromosome band present on 3p"], "t": []}], "preferred_name": "3p21.3", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C1167227", "l": "integrin complex", "d": [], "t": []}], "preferred_name": "integrin complex", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C4325612", "l": "p155 complex", "d": [], "t": []}], "preferred_name": "p155 complex", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C1167076", "l": "nuclear ubiquitin ligase complex", "d": [], "t": []}], "preferred_name": "nuclear ubiquitin ligase complex", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C1623087", "l": "extrinsic component of cell outer membrane", "d": [], "t": []}], "preferred_name": "extrinsic component of cell outer membrane", "taxa": []} {"type": "biolink:CellularComponent", "ic": "100", "identifiers": [{"i": "GO:0000812", "l": "Swr1 complex", "d": ["A multisubunit protein complex that is involved in chromatin remodeling. It is required for the incorporation of the histone variant H2AZ into chromatin. In S. cerevisiae, the complex contains Swr1p, a Swi2/Snf2-related ATPase, and 12 additional subunits."], "t": []}], "preferred_name": "Swr1 complex", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C3824526", "l": "Atg1/ULK1 kinase complex", "d": [], "t": []}], "preferred_name": "Atg1/ULK1 kinase complex", "taxa": []} {"type": "biolink:CellularComponent", "ic": "90.860573823805353", "identifiers": [{"i": "GO:0035449", "l": "extrinsic component of plastid thylakoid membrane", "d": ["The component of a plastid thylakoid membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region."], "t": []}], "preferred_name": "extrinsic component of plastid thylakoid membrane", "taxa": []} {"type": "biolink:CellularComponent", "ic": "100", "identifiers": [{"i": "GO:1990374", "l": "Kir2 inward rectifier potassium channel complex", "d": ["A inward rectifier potassium channel complex. Homo- or heterotetramer composed of subunits of the eukaryotic Kir2 protein family. Plays a key role in maintaining the correct resting potential in eukaryotic cells."], "t": []}], "preferred_name": "Kir2 inward rectifier potassium channel complex", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C1622630", "l": "nuclear proteasome core complex", "d": [], "t": []}], "preferred_name": "nuclear proteasome core complex", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C2244316", "l": "proteasome-activating nucleotidase complex", "d": [], "t": []}], "preferred_name": "proteasome-activating nucleotidase complex", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C3546479", "l": "sperm protein complex I", "d": [], "t": []}], "preferred_name": "sperm protein complex I", "taxa": []} {"type": "biolink:CellularComponent", "ic": "100", "identifiers": [{"i": "GO:0044841", "l": "gut granule membrane", "d": ["The membrane of a gut granule, a lysosome-related organelle contained within the intestinal cells of the nematode C. elegans."], "t": []}], "preferred_name": "gut granule membrane", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C3268864", "l": "Meiotic Spindle Apparatus", "d": [], "t": []}], "preferred_name": "Meiotic Spindle Apparatus", "taxa": []} {"type": "biolink:CellularComponent", "ic": "100", "identifiers": [{"i": "GO:1990235", "l": "diamine N-acetyltransferase complex", "d": ["A protein complex which is capable of diamine N-acetyltransferase activity."], "t": []}], "preferred_name": "diamine N-acetyltransferase complex", "taxa": []} {"type": "biolink:CellularComponent", "ic": "95.43028691190267", "identifiers": [{"i": "GO:0048494", "l": "chromatophore ribulose bisphosphate carboxylase complex", "d": ["A complex, located in the chromatophore, containing either both large and small subunits or just small subunits which carries out the activity of producing 3-phosphoglycerate from carbon dioxide and ribulose-1,5-bisphosphate."], "t": []}], "preferred_name": "chromatophore ribulose bisphosphate carboxylase complex", "taxa": []} {"type": "biolink:CellularComponent", "ic": "100", "identifiers": [{"i": "GO:0170051", "l": "box C/D methylation guide scaRNP complex", "d": ["A ribonucleoprotein complex containing a small CB-specific RNA (scaRNA), with a short sequence motif (GU/UG wobble stem) for CB localization that is capable of methylation of target RNAs."], "t": []}], "preferred_name": "box C/D methylation guide scaRNP complex", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C2754989", "l": "polymeric IgA immunoglobulin complex", "d": [], "t": []}], "preferred_name": "polymeric IgA immunoglobulin complex", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C1179434", "l": "Region of actin filament", "d": [], "t": []}], "preferred_name": "Region of actin filament", "taxa": []} {"type": "biolink:CellularComponent", "ic": "100", "identifiers": [{"i": "GO:1990836", "l": "lysosomal matrix", "d": ["A matrix composed of supramolecular assemblies of lysosomal enzymes and lipids which forms at a pH of 5.0 within the lysosome."], "t": []}], "preferred_name": "lysosomal matrix", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C1167206", "l": "auxin efflux carrier complex", "d": [], "t": []}], "preferred_name": "auxin efflux carrier complex", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C1525451", "l": "Basement membrane zone", "d": [], "t": []}], "preferred_name": "Basement membrane zone", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C1621412", "l": "contractile vacuolar membrane", "d": [], "t": []}], "preferred_name": "contractile vacuolar membrane", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C3893910", "l": "silver ion transmembrane transporter complex", "d": [], "t": []}], "preferred_name": "silver ion transmembrane transporter complex", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C1179932", "l": "Vacuoplasm", "d": [], "t": []}], "preferred_name": "Vacuoplasm", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C1183507", "l": "Subdivision of cytosol", "d": [], "t": []}], "preferred_name": "Subdivision of cytosol", "taxa": []} {"type": "biolink:CellularComponent", "ic": "100", "identifiers": [{"i": "GO:0005655", "l": "nucleolar ribonuclease P complex", "d": ["A ribonuclease P complex located in the nucleolus of a eukaryotic cell, where it catalyzes the 5' endonucleolytic cleavage of precursor tRNAs to yield mature tRNAs. 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ERBB3 has impaired kinase activity so relies on the kinase activity of its heterodimer partner for activation and signal transmission."], "t": []}], "preferred_name": "ERBB4-ERBB3 complex", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C4329005", "l": "cortical dynamic polarity patch", "d": [], "t": []}], "preferred_name": "cortical dynamic polarity patch", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C4235097", "l": "nuclear membrane complex Bqt3-Bqt4", "d": [], "t": []}], "preferred_name": "nuclear membrane complex Bqt3-Bqt4", "taxa": []} {"type": "biolink:CellularComponent", "ic": "100", "identifiers": [{"i": "GO:0062116", "l": "phenyloplast", "d": ["A chloroplast-derived plastid in which the solid form of phenol is stored."], "t": []}], "preferred_name": "phenyloplast", "taxa": []} {"type": "biolink:CellularComponent", "ic": "100", "identifiers": [{"i": "GO:1990321", "l": "collagen type XXII trimer", "d": ["A collagen homotrimer of alpha1(XXII) chains; type XXII collagen triple helices acts as a cell adhesion ligand for skin epithelial cells and fibroblasts."], "t": []}], "preferred_name": "collagen type XXII trimer", "taxa": []} {"type": "biolink:CellularComponent", "ic": "100", "identifiers": [{"i": "GO:0071015", "l": "U12-type prespliceosome", "d": ["A spliceosomal complex that is formed by the cooperative binding of the heterodimeric U11/U12 snRNP to the 5' splice site and the branch point sequence. 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"biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C1325751", "l": "porous cell septum", "d": [], "t": []}], "preferred_name": "porous cell septum", "taxa": []} {"type": "biolink:CellularComponent", "ic": "84.191390054935425", "identifiers": [{"i": "UMLS:C1521490", "l": "5q32", "d": [], "t": []}, {"i": "NCIT:C14126", "l": "5q32", "d": ["A chromosome band present on 5q"], "t": []}], "preferred_name": "5q32", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C4327168", "l": "CENP-T-W-S-X complex", "d": [], "t": []}], "preferred_name": "CENP-T-W-S-X complex", "taxa": []} {"type": "biolink:CellularComponent", "ic": "100", "identifiers": [{"i": "GO:0044538", "l": "host cell periphery", "d": ["The part of a cell encompassing the cell cortex, the plasma membrane, and any external encapsulating structures of a host cell."], "t": []}], "preferred_name": "host cell periphery", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, 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Its components include the EF-hand-containing proteins mitochondrial calcium uptake 1 (MICU1) and MICU2, the pore-forming subunit mitochondrial calcium uniporter (MCU) and its paralog MCUb, and the MCU regulator EMRE."], "t": []}], "preferred_name": "uniplex complex", "taxa": []} {"type": "biolink:CellularComponent", "ic": "100", "identifiers": [{"i": "GO:0033290", "l": "eukaryotic 48S preinitiation complex", "d": ["The protein-ribosome-tRNA complex that has just recognized the start codon of a capped mRNA. It is composed of the small ribosomal subunit, eukaryote initiation factors (eIF) eIF3 complex, eIF1, eIF1A, eIF2-GDP, eIF4 complex and initiatior-methionine-tRNA. Recognition of the start codon triggers downstream steps in the pathway, including eIF1 dissociation; Pi release from eIF2; and conversion to the closed, scanning-arrested conformation of the PIC."], "t": []}], "preferred_name": "eukaryotic 48S preinitiation complex", "taxa": []} {"type": "biolink:CellularComponent", "ic": "86.290860735708023", "identifiers": [{"i": "UMLS:C1710908", "l": "1q25.2", "d": [], "t": []}, {"i": "NCIT:C45167", "l": "1q25.2", "d": ["Part of the chromosome bands present on the long (q) arm of chromosome 1."], "t": []}], "preferred_name": "1q25.2", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C3546527", "l": "FAR/SIN/STRIPAK complex", "d": [], "t": []}], "preferred_name": "FAR/SIN/STRIPAK complex", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C1654774", "l": "SCF4 complex", "d": [], "t": []}], "preferred_name": "SCF4 complex", "taxa": []} {"type": "biolink:CellularComponent", "ic": "100", "identifiers": [{"i": "GO:0030937", "l": "collagen type XVII trimer", "d": ["A collagen homotrimer of alpha1(XVII) chains; type XVII collagen triple helices span the plasma membrane and associate with hemidesmosomes and the basal lamina where they bind laminin."], "t": []}], "preferred_name": "collagen type XVII trimer", "taxa": []} {"type": "biolink:CellularComponent", "ic": "95.43028691190267", "identifiers": [{"i": "GO:0045298", "l": "tubulin complex", "d": ["A heterodimer of tubulins alpha and beta that constitutes the protomer for microtubule assembly."], "t": []}], "preferred_name": "tubulin complex", "taxa": []} {"type": "biolink:CellularComponent", "ic": "100", "identifiers": [{"i": "GO:0000159", "l": "protein phosphatase type 2A complex", "d": ["A protein complex that has protein serine/threonine phosphatase activity that is polycation-stimulated (PCS), being directly stimulated by protamine, polylysine, or histone H1; it constitutes a subclass of several enzymes activated by different histones and polylysine, and consists of catalytic, scaffolding, and regulatory subunits. The catalytic and scaffolding subunits form the core enzyme, and the holoenzyme also includes the regulatory subunit."], "t": []}], "preferred_name": "protein phosphatase type 2A complex", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C3821365", "l": "collagen beaded filament", "d": [], "t": []}], "preferred_name": "collagen beaded filament", "taxa": []} {"type": "biolink:CellularComponent", "ic": "95.43028691190267", "identifiers": [{"i": "GO:0042644", "l": "chloroplast nucleoid", "d": ["The region of a chloroplast to which the DNA is confined."], "t": []}], "preferred_name": "chloroplast nucleoid", "taxa": []} {"type": "biolink:CellularComponent", "ic": "100", "identifiers": [{"i": "GO:0071188", "l": "protocadherin-alpha-v7-protocadherin-gamma-a1 complex", "d": ["A protein complex that contains the cell adhesion molecules protocadherin-alpha-v7 and protocadherin-gamma-a1, and is involved in the regulation of protein localization to the plasma membrane."], "t": []}], "preferred_name": "protocadherin-alpha-v7-protocadherin-gamma-a1 complex", "taxa": []} {"type": "biolink:CellularComponent", "ic": "100", "identifiers": [{"i": "GO:0042718", "l": "yolk granule", "d": ["Discrete structures that partition the water-insoluble portion of the yolk of oocytes and ova, which may or may not be membrane enclosed."], "t": []}], "preferred_name": "yolk granule", "taxa": []} {"type": "biolink:CellularComponent", "ic": "87.171193469738924", "identifiers": [{"i": "GO:0000782", "l": "telomere cap complex", "d": ["A complex of DNA and protein located at the end of a linear chromosome that protects and stabilizes a linear chromosome."], "t": []}], "preferred_name": "telomere cap complex", "taxa": []} {"type": "biolink:CellularComponent", "ic": "92.757176116311072", "identifiers": [{"i": "GO:0044191", "l": "host cell mitochondrial membrane", "d": ["Either of the lipid bilayers that surround the host cell mitochondrion and form the host cell mitochondrial envelope."], "t": []}], "preferred_name": "host cell mitochondrial membrane", "taxa": []} {"type": "biolink:CellularComponent", "ic": "79.621676966838109", "identifiers": [{"i": "NCIT:C13542", "l": "16q", "d": ["Distal (long) arm of chromosome 16"], "t": []}], "preferred_name": "16q", "taxa": []} {"type": "biolink:CellularComponent", "ic": "100", "identifiers": [{"i": "GO:0098557", "l": "cytoplasmic side of smooth endoplasmic reticulum membrane", "d": ["The side (leaflet) of the smooth endoplasmic reticulum membrane that faces the cytoplasm."], "t": []}], "preferred_name": "cytoplasmic side of smooth endoplasmic reticulum membrane", "taxa": []} {"type": "biolink:CellularComponent", "ic": "84.191390054935425", "identifiers": [{"i": "UMLS:C2825991", "l": "8p21.3", "d": [], "t": []}, {"i": "NCIT:C82141", "l": "8p21.3", "d": ["A chromosome band present on 8p."], "t": []}], "preferred_name": "8p21.3", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C1166721", "l": "SCF ubiquitin ligase complex", "d": [], "t": []}], "preferred_name": "SCF ubiquitin ligase complex", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C5137370", "l": "pollen aperture", "d": [], "t": []}], "preferred_name": "pollen aperture", "taxa": []} {"type": "biolink:CellularComponent", "ic": "67.281442243230913", "identifiers": [{"i": "GO:0099568", "l": "cytoplasmic region", "d": ["Any (proper) part of the cytoplasm of a single cell of sufficient size to still be considered cytoplasm."], "t": []}], "preferred_name": "cytoplasmic region", "taxa": []} {"type": "biolink:CellularComponent", "ic": "100", "identifiers": [{"i": "GO:0034206", "l": "enhanceosome", "d": ["A protein-DNA complex formed by the association of a distinct set of general and specific transcription factors with a region of enhancer DNA. 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In S. cerevisiae, it is composed of four subunits: Hpr1, Tho2, Thp2, and Mft1, while the human complex is composed of 7 subunits."], "t": []}], "preferred_name": "nucleoplasmic THO complex", "taxa": []} {"type": "biolink:CellularComponent", "ic": "100", "identifiers": [{"i": "GO:0033016", "l": "rhoptry membrane", "d": ["The lipid bilayer surrounding a rhoptry."], "t": []}], "preferred_name": "rhoptry membrane", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C1166916", "l": "mitochondrial proton-transporting ATP synthase complex location, catalytic sector F(1)", "d": [], "t": []}], "preferred_name": "mitochondrial proton-transporting ATP synthase complex location, catalytic sector F(1)", "taxa": []} {"type": "biolink:CellularComponent", "ic": "79.048036852019095", "identifiers": [{"i": "GO:0065010", "l": "extracellular membrane-bounded organelle", "d": ["Organized structure of distinctive morphology and function, bounded by a lipid bilayer membrane and occurring outside the cell."], "t": []}], "preferred_name": "extracellular membrane-bounded organelle", "taxa": []} {"type": "biolink:CellularComponent", "ic": "100", "identifiers": [{"i": "GO:1990733", "l": "titin-telethonin complex", "d": ["A protein complex formed between the N-terminus of the giant sarcomeric filament protein titin and the Z-disk ligand, telethonin. 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The Saccharomyces complex contains several identifiable subcomplexes: a head domain comprising Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p; and a regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins."], "t": []}], "preferred_name": "mediator complex", "taxa": []} {"type": "biolink:CellularComponent", "ic": "100", "identifiers": [{"i": "GO:0033105", "l": "chlorosome envelope", "d": ["The structure, composed of a monolayer of glycolipids with embedded proteins, that encloses the pigments and other contents of the chlorosome."], "t": []}], "preferred_name": "chlorosome envelope", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C3156649", "l": "sRNP complex", "d": [], "t": []}], "preferred_name": "sRNP complex", "taxa": []} {"type": "biolink:CellularComponent", "ic": "95.43028691190267", "identifiers": [{"i": "GO:0038104", "l": "nodal receptor complex", "d": ["A protein complex containing at least a type II activin receptor, a type I activin receptor, and a coreceptor (EGF-CFC protein) such as Cripto or Cryptic. 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In organisms with two membranes, the substrate-binding protein moves freely in the periplasmic space and joins the other subunits only when bound with substrate. In organisms with only one membrane the substrate-binding protein is tethered to the cytoplasmic membrane and associated with the other subunits. 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In S. cerevisiae the complex contains Seh1p, Sec13p, Npr2p, Npr3p, Iml1p, Mtc5p, Rtc1p, and Sea4p."], "t": []}], "preferred_name": "Seh1-associated complex", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C1167176", "l": "GT-AG spliceosome", "d": [], "t": []}], "preferred_name": "GT-AG spliceosome", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C5450542", "l": "box C/D sRNP complex", "d": [], "t": []}], "preferred_name": "box C/D sRNP complex", "taxa": []} {"type": "biolink:CellularComponent", "ic": "92.757176116311072", "identifiers": [{"i": "UMLS:C1521494", "l": "5q33.2", "d": [], "t": []}, {"i": "NCIT:C13838", "l": "5q33.2", "d": ["A chromosome band present on 5q"], "t": []}], "preferred_name": "5q33.2", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C4328950", "l": "extrinsic component of neuronal dense core vesicle membrane", "d": [], "t": []}], "preferred_name": "extrinsic component of neuronal dense core vesicle membrane", "taxa": []} {"type": "biolink:CellularComponent", "ic": null, "identifiers": [{"i": "UMLS:C0333900", "l": "Perinuclear halo", "d": [], "t": []}, {"i": "SNOMEDCT:59145000", "d": [], "t": []}], "preferred_name": "Perinuclear halo", "taxa": []} {"type": "biolink:CellularComponent", "ic": "100", "identifiers": [{"i": "GO:0035580", "l": "specific granule lumen", "d": ["The volume enclosed by the membrane of a specific granule, a granule with a membranous, tubular internal structure, found primarily in mature neutrophil cells. 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