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Glycine N-methyltransferase catalyzes the synthesis of N-methylglycine (sarcosine) from glycine using S-adenosylmethionine (AdoMet) as the methyl donor. GNMT acts as an enzyme to regulate the ratio of S-adenosylmethionine to S-adenosylhomocysteine (AdoHcy) and participates in the detoxification pathway in liver cells. A defect in this enzyme causes accumulation of methionine in the plasma and transaminases in the serum. Symptoms include hepatomegaly.", "d": [], "t": []}], "preferred_name": "Glycine N-Methyltransferase Deficiency,Disease,Glycine N-methyltransferase deficiency (GNMT deficiency) is caused by mutation in the GNMT gene (606628). Glycine N-methyltransferase catalyzes the synthesis of N-methylglycine (sarcosine) from glycine using S-adenosylmethionine (AdoMet) as the methyl donor. GNMT acts as an enzyme to regulate the ratio of S-adenosylmethionine to S-adenosylhomocysteine (AdoHcy) and participates in the detoxification pathway in liver cells. A defect in this enzyme causes accumulation of methionine in the plasma and transaminases in the serum. Symptoms include hepatomegaly.", "taxa": []} {"type": "biolink:Pathway", "ic": null, "identifiers": [{"i": "SMPDB:SMP0055984", "l": "Cardiolipin Biosynthesis CL(i-13:0/a-17:0/a-21:0/a-21:0),Disease", "d": [], "t": []}], "preferred_name": "Cardiolipin Biosynthesis CL(i-13:0/a-17:0/a-21:0/a-21:0),Disease", "taxa": []} {"type": "biolink:Pathway", "ic": null, "identifiers": [{"i": "SMPDB:SMP0041632", "l": "De Novo Triacylglycerol Biosynthesis TG(i-22:0/12:0/i-18:0),Metabolic", "d": [], "t": []}], "preferred_name": "De Novo Triacylglycerol Biosynthesis TG(i-22:0/12:0/i-18:0),Metabolic", "taxa": []} {"type": "biolink:Pathway", "ic": null, "identifiers": [{"i": "REACT:R-DRE-1236977", "l": "Endosomal/Vacuolar pathway (Danio rerio)", "d": [], "t": []}], "preferred_name": "Endosomal/Vacuolar pathway (Danio rerio)", "taxa": []} {"type": "biolink:Pathway", "ic": null, "identifiers": [{"i": "SMPDB:SMP0035993", "l": "De Novo Triacylglycerol Biosynthesis TG(21:0/i-24:0/8:0),Metabolic", "d": [], "t": []}], "preferred_name": "De Novo Triacylglycerol Biosynthesis TG(21:0/i-24:0/8:0),Metabolic", "taxa": []} {"type": "biolink:Pathway", "ic": null, "identifiers": [{"i": "REACT:R-SCE-3214841", "l": "PKMTs methylate histone lysines (Saccharomyces cerevisiae)", "d": [], "t": []}], "preferred_name": "PKMTs methylate histone lysines (Saccharomyces cerevisiae)", "taxa": []} {"type": "biolink:Pathway", "ic": null, "identifiers": [{"i": "SMPDB:SMP0034177", "l": "De Novo Triacylglycerol Biosynthesis TG(20:0/i-15:0/i-15:0),Metabolic", "d": [], "t": []}], "preferred_name": "De Novo Triacylglycerol Biosynthesis TG(20:0/i-15:0/i-15:0),Metabolic", "taxa": []} {"type": "biolink:Pathway", "ic": null, "identifiers": [{"i": "REACT:R-HSA-199418", "l": "Negative regulation of the PI3K/AKT network (Homo sapiens)", "d": [], "t": []}], "preferred_name": "Negative regulation of the PI3K/AKT network (Homo sapiens)", "taxa": []} {"type": "biolink:Pathway", "ic": null, "identifiers": [{"i": "REACT:R-DDI-212436", "l": "Generic Transcription Pathway (Dictyostelium discoideum)", "d": [], "t": []}], "preferred_name": "Generic Transcription Pathway (Dictyostelium discoideum)", "taxa": []} {"type": "biolink:Pathway", "ic": null, "identifiers": [{"i": "REACT:R-HSA-202427", "l": "Phosphorylation of CD3 and TCR zeta chains (Homo sapiens)", "d": [], "t": []}], "preferred_name": "Phosphorylation of CD3 and TCR zeta chains (Homo sapiens)", "taxa": []} {"type": "biolink:Pathway", "ic": null, "identifiers": [{"i": "REACT:R-DME-168176", "l": "Toll Like Receptor 5 (TLR5) Cascade (Drosophila melanogaster)", "d": [], "t": []}], "preferred_name": "Toll Like Receptor 5 (TLR5) Cascade (Drosophila melanogaster)", "taxa": []} {"type": "biolink:Pathway", "ic": null, "identifiers": [{"i": "REACT:R-SPO-163125", "l": "Post-translational modification: synthesis of GPI-anchored proteins (Schizosaccharomyces pombe)", "d": [], "t": []}], "preferred_name": "Post-translational modification: synthesis of GPI-anchored proteins (Schizosaccharomyces pombe)", "taxa": []} {"type": "biolink:Pathway", "ic": null, "identifiers": [{"i": "SMPDB:SMP0044405", "l": "Cardiolipin Biosynthesis CL(a-13:0/a-17:0/i-12:0/i-15:0),Disease", "d": [], "t": []}], "preferred_name": "Cardiolipin Biosynthesis CL(a-13:0/a-17:0/i-12:0/i-15:0),Disease", "taxa": []} {"type": "biolink:Pathway", "ic": null, "identifiers": [{"i": "REACT:R-CEL-4090294", "l": "SUMOylation of intracellular receptors (Caenorhabditis elegans)", "d": [], "t": []}], "preferred_name": "SUMOylation of intracellular receptors (Caenorhabditis elegans)", "taxa": []} {"type": "biolink:Pathway", "ic": null, "identifiers": [{"i": "REACT:R-PFA-9609523", "l": "Insertion of tail-anchored proteins into the endoplasmic reticulum membrane (Plasmodium falciparum)", "d": [], "t": []}], "preferred_name": "Insertion of tail-anchored proteins into the endoplasmic reticulum membrane (Plasmodium falciparum)", "taxa": []} {"type": "biolink:Pathway", "ic": null, "identifiers": [{"i": "SMPDB:SMP0063023", "l": "Cardiolipin Biosynthesis CL(i-14:0/i-16:0/a-17:0/i-20:0),Disease", "d": [], "t": []}], "preferred_name": "Cardiolipin Biosynthesis CL(i-14:0/i-16:0/a-17:0/i-20:0),Disease", "taxa": []} {"type": "biolink:Pathway", "ic": null, "identifiers": [{"i": "SMPDB:SMP0033747", "l": "De Novo Triacylglycerol Biosynthesis TG(20:0/18:0/i-24:0),Metabolic", "d": [], "t": []}], "preferred_name": "De Novo Triacylglycerol Biosynthesis TG(20:0/18:0/i-24:0),Metabolic", "taxa": []} {"type": "biolink:Pathway", "ic": null, "identifiers": [{"i": "REACT:R-SCE-159418", "l": "Recycling of bile acids and salts (Saccharomyces cerevisiae)", "d": [], "t": []}], "preferred_name": "Recycling of bile acids and salts (Saccharomyces cerevisiae)", "taxa": []} {"type": "biolink:Pathway", "ic": null, "identifiers": [{"i": "SMPDB:SMP0042942", "l": "De Novo Triacylglycerol Biosynthesis TG(i-24:0/a-21:0/i-22:0),Metabolic", "d": [], "t": []}], "preferred_name": "De Novo Triacylglycerol Biosynthesis TG(i-24:0/a-21:0/i-22:0),Metabolic", "taxa": []} {"type": "biolink:Pathway", "ic": null, "identifiers": [{"i": "SMPDB:SMP0049738", "l": "Cardiolipin Biosynthesis CL(i-12:0/a-13:0/i-22:0/i-13:0),Disease", "d": [], "t": []}], "preferred_name": "Cardiolipin Biosynthesis CL(i-12:0/a-13:0/i-22:0/i-13:0),Disease", "taxa": []} {"type": "biolink:Pathway", "ic": null, "identifiers": [{"i": "SMPDB:SMP0048218", "l": "Cardiolipin Biosynthesis CL(a-13:0/i-21:0/a-17:0/i-15:0),Disease", "d": [], "t": []}], "preferred_name": "Cardiolipin Biosynthesis CL(a-13:0/i-21:0/a-17:0/i-15:0),Disease", "taxa": []} {"type": "biolink:Pathway", "ic": null, "identifiers": [{"i": "SMPDB:SMP0044874", "l": "Cardiolipin Biosynthesis CL(a-13:0/a-21:0/i-20:0/i-17:0),Disease", "d": [], "t": []}], "preferred_name": "Cardiolipin Biosynthesis CL(a-13:0/a-21:0/i-20:0/i-17:0),Disease", "taxa": []} {"type": "biolink:Pathway", "ic": null, "identifiers": [{"i": "SMPDB:SMP0036611", "l": "De Novo Triacylglycerol Biosynthesis TG(22:0/i-16:0/a-25:0),Metabolic", "d": [], "t": []}], "preferred_name": "De Novo Triacylglycerol Biosynthesis TG(22:0/i-16:0/a-25:0),Metabolic", "taxa": []} {"type": "biolink:Pathway", "ic": null, "identifiers": [{"i": "SMPDB:SMP0051549", "l": "Cardiolipin Biosynthesis CL(i-12:0/i-13:0/i-15:0/a-13:0),Disease", "d": [], "t": []}], "preferred_name": "Cardiolipin Biosynthesis CL(i-12:0/i-13:0/i-15:0/a-13:0),Disease", "taxa": []} {"type": "biolink:Pathway", "ic": null, "identifiers": [{"i": "REACT:R-PFA-975956", "l": "Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) (Plasmodium falciparum)", "d": [], "t": []}], "preferred_name": "Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) (Plasmodium falciparum)", "taxa": []} {"type": "biolink:Pathway", "ic": null, "identifiers": [{"i": "REACT:R-BTA-2022870", "l": "Chondroitin sulfate biosynthesis (Bos taurus)", "d": [], "t": []}], "preferred_name": "Chondroitin sulfate biosynthesis (Bos taurus)", "taxa": []} {"type": "biolink:Pathway", "ic": null, "identifiers": [{"i": "SMPDB:SMP0043803", "l": "Cardiolipin Biosynthesis CL(a-13:0/a-13:0/i-14:0/i-22:0),Disease", "d": [], "t": []}], "preferred_name": "Cardiolipin Biosynthesis CL(a-13:0/a-13:0/i-14:0/i-22:0),Disease", "taxa": []} {"type": "biolink:Pathway", "ic": null, "identifiers": [{"i": "SMPDB:SMP0058248", "l": "Cardiolipin Biosynthesis CL(i-13:0/i-16:0/a-17:0/i-13:0),Disease", "d": [], "t": []}], "preferred_name": "Cardiolipin Biosynthesis CL(i-13:0/i-16:0/a-17:0/i-13:0),Disease", "taxa": []} {"type": "biolink:Pathway", "ic": "100", "identifiers": [{"i": "GO:0071883", "l": "MAPK-activating adrenergic receptor signaling pathway", "d": ["The series of molecular signals generated as a consequence of an adrenergic receptor binding to its physiological ligand and leading to the activation of a MAP kinase cascade."], "t": []}], "preferred_name": "MAPK-activating adrenergic receptor signaling pathway", "taxa": []} {"type": "biolink:Pathway", "ic": null, "identifiers": [{"i": "REACT:R-DME-983170", "l": "Antigen Presentation: Folding, assembly and peptide loading of class I MHC (Drosophila melanogaster)", "d": [], "t": []}], "preferred_name": "Antigen Presentation: Folding, assembly and peptide loading of class I MHC (Drosophila melanogaster)", "taxa": []} {"type": "biolink:Pathway", "ic": null, "identifiers": [{"i": "SMPDB:SMP0060886", "l": "Cardiolipin Biosynthesis CL(i-14:0/a-13:0/a-17:0/a-15:0),Disease", "d": [], "t": []}], "preferred_name": "Cardiolipin Biosynthesis CL(i-14:0/a-13:0/a-17:0/a-15:0),Disease", "taxa": []} {"type": "biolink:Pathway", "ic": "90.864014659442475", "identifiers": [{"i": "GO:0034158", "l": "toll-like receptor 8 signaling pathway", "d": ["The series of molecular signals initiated by a ligand binding to the endolysosomal toll-like receptor 8."], "t": []}], "preferred_name": "toll-like receptor 8 signaling pathway", "taxa": []} {"type": "biolink:Pathway", "ic": null, "identifiers": [{"i": "REACT:R-SSC-8934593", "l": "Regulation of RUNX1 Expression and Activity (Sus scrofa)", "d": [], "t": []}], "preferred_name": "Regulation of RUNX1 Expression and Activity (Sus scrofa)", "taxa": []} {"type": "biolink:Pathway", "ic": null, "identifiers": [{"i": "REACT:R-PFA-174824", "l": "Plasma lipoprotein assembly, remodeling, and clearance (Plasmodium falciparum)", "d": [], "t": []}], "preferred_name": "Plasma lipoprotein assembly, remodeling, and clearance (Plasmodium falciparum)", "taxa": []} {"type": "biolink:Pathway", "ic": null, "identifiers": [{"i": "SMPDB:SMP0061057", "l": "Cardiolipin Biosynthesis CL(i-14:0/a-13:0/i-18:0/i-16:0),Disease", "d": [], "t": []}], "preferred_name": "Cardiolipin Biosynthesis CL(i-14:0/a-13:0/i-18:0/i-16:0),Disease", "taxa": []} {"type": "biolink:Pathway", "ic": null, "identifiers": [{"i": "REACT:R-SSC-69481", "l": "G2/M Checkpoints (Sus scrofa)", "d": [], "t": []}], "preferred_name": "G2/M Checkpoints (Sus scrofa)", "taxa": []} {"type": "biolink:Pathway", "ic": null, "identifiers": [{"i": "SMPDB:SMP0033875", "l": "De Novo Triacylglycerol Biosynthesis TG(20:0/22:0/a-13:0),Metabolic", "d": [], "t": []}], "preferred_name": "De Novo Triacylglycerol Biosynthesis TG(20:0/22:0/a-13:0),Metabolic", "taxa": []} {"type": "biolink:Pathway", "ic": null, "identifiers": [{"i": "REACT:R-HSA-446205", "l": "Synthesis of GDP-mannose (Homo sapiens)", "d": [], "t": []}], "preferred_name": "Synthesis of GDP-mannose (Homo sapiens)", "taxa": []} {"type": "biolink:Pathway", "ic": null, "identifiers": [{"i": "SMPDB:SMP0000354", "l": "Intracellular Signalling Through Prostacyclin Receptor and Prostacyclin,Signaling", "d": [], "t": []}], "preferred_name": "Intracellular Signalling Through Prostacyclin Receptor and Prostacyclin,Signaling", "taxa": []} {"type": "biolink:Pathway", "ic": null, "identifiers": [{"i": "REACT:R-XTR-8986944", "l": "Transcriptional Regulation by MECP2 (Xenopus tropicalis)", "d": [], "t": []}], "preferred_name": "Transcriptional Regulation by MECP2 (Xenopus tropicalis)", "taxa": []} {"type": "biolink:Pathway", "ic": null, "identifiers": [{"i": "REACT:R-GGA-975576", "l": "N-glycan antennae elongation in the medial/trans-Golgi (Gallus gallus)", "d": [], "t": []}], "preferred_name": "N-glycan antennae elongation in the medial/trans-Golgi (Gallus gallus)", "taxa": []} {"type": "biolink:Pathway", "ic": null, "identifiers": [{"i": "SMPDB:SMP0056140", "l": "Cardiolipin Biosynthesis CL(i-13:0/a-17:0/i-18:0/i-20:0),Disease", "d": [], "t": []}], "preferred_name": "Cardiolipin Biosynthesis CL(i-13:0/a-17:0/i-18:0/i-20:0),Disease", "taxa": []} {"type": "biolink:Pathway", "ic": null, "identifiers": [{"i": "REACT:R-DME-425381", "l": "Bicarbonate transporters (Drosophila melanogaster)", "d": [], "t": []}], "preferred_name": "Bicarbonate transporters (Drosophila melanogaster)", "taxa": []} {"type": "biolink:Pathway", "ic": null, "identifiers": [{"i": "SMPDB:SMP0035741", "l": "De Novo Triacylglycerol 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"l": "Cardiolipin Biosynthesis CL(a-13:0/i-13:0/i-22:0/i-18:0),Disease", "d": [], "t": []}], "preferred_name": "Cardiolipin Biosynthesis CL(a-13:0/i-13:0/i-22:0/i-18:0),Disease", "taxa": []} {"type": "biolink:Pathway", "ic": null, "identifiers": [{"i": "REACT:R-CEL-6798695", "l": "Neutrophil degranulation (Caenorhabditis elegans)", "d": [], "t": []}], "preferred_name": "Neutrophil degranulation (Caenorhabditis elegans)", "taxa": []} {"type": "biolink:Pathway", "ic": null, "identifiers": [{"i": "SMPDB:SMP0036396", "l": "De Novo Triacylglycerol Biosynthesis TG(22:0/a-17:0/15:0),Metabolic", "d": [], "t": []}], "preferred_name": "De Novo Triacylglycerol Biosynthesis TG(22:0/a-17:0/15:0),Metabolic", "taxa": []} {"type": "biolink:Pathway", "ic": null, "identifiers": [{"i": "SMPDB:SMP0061670", "l": "Cardiolipin Biosynthesis CL(i-14:0/i-12:0/a-13:0/a-25:0),Disease", "d": [], "t": []}], "preferred_name": "Cardiolipin Biosynthesis CL(i-14:0/i-12:0/a-13:0/a-25:0),Disease", "taxa": []} {"type": "biolink:Pathway", "ic": null, "identifiers": [{"i": "SMPDB:SMP0053212", "l": "Cardiolipin Biosynthesis CL(i-12:0/i-18:0/i-17:0/i-19:0),Disease", "d": [], "t": []}], "preferred_name": "Cardiolipin Biosynthesis CL(i-12:0/i-18:0/i-17:0/i-19:0),Disease", "taxa": []} {"type": "biolink:Pathway", "ic": null, "identifiers": [{"i": "REACT:R-GGA-5684264", "l": "MAP3K8 (TPL2)-dependent MAPK1/3 activation (Gallus gallus)", "d": [], "t": []}], "preferred_name": "MAP3K8 (TPL2)-dependent MAPK1/3 activation (Gallus gallus)", "taxa": []} {"type": "biolink:Pathway", "ic": "100", "identifiers": [{"i": "GO:0007232", "l": "osmosensory signaling pathway via Sho1 osmosensor", "d": ["The series of molecular signals generated in response to osmotic change, as mediated through a Sho1 osmosensor system."], "t": []}], "preferred_name": "osmosensory signaling pathway via Sho1 osmosensor", "taxa": []} {"type": "biolink:Pathway", "ic": null, "identifiers": [{"i": "REACT:R-HSA-216083", "l": "Integrin cell surface interactions (Homo sapiens)", "d": [], "t": []}], "preferred_name": "Integrin cell surface interactions (Homo sapiens)", "taxa": []} {"type": "biolink:Pathway", "ic": null, "identifiers": [{"i": "SMPDB:SMP0062318", "l": "Cardiolipin Biosynthesis CL(i-14:0/i-14:0/a-13:0/i-14:0),Disease", "d": [], "t": []}], "preferred_name": "Cardiolipin Biosynthesis CL(i-14:0/i-14:0/a-13:0/i-14:0),Disease", "taxa": []} {"type": "biolink:Pathway", "ic": null, "identifiers": [{"i": "REACT:R-DRE-8981373", "l": "Intestinal hexose absorption (Danio rerio)", "d": [], "t": []}], "preferred_name": "Intestinal hexose absorption (Danio rerio)", "taxa": []} {"type": "biolink:Pathway", "ic": null, "identifiers": [{"i": "REACT:R-BTA-141424", "l": "Amplification of signal from the kinetochores (Bos taurus)", "d": [], "t": []}], "preferred_name": "Amplification of signal from the kinetochores (Bos taurus)", "taxa": []} {"type": "biolink:Pathway", "ic": null, "identifiers": [{"i": "REACT:R-MMU-69186", "l": "Lagging Strand Synthesis (Mus musculus)", "d": [], "t": []}], "preferred_name": "Lagging Strand Synthesis (Mus musculus)", "taxa": []} {"type": "biolink:Pathway", "ic": null, "identifiers": [{"i": "SMPDB:SMP0026275", "l": "De Novo Triacylglycerol Biosynthesis TG(20:0/14:0/10:0),Metabolic", "d": [], "t": []}], "preferred_name": "De Novo Triacylglycerol Biosynthesis TG(20:0/14:0/10:0),Metabolic", "taxa": []} {"type": "biolink:Pathway", "ic": null, "identifiers": [{"i": "REACT:R-SCE-9006931", "l": "Signaling by Nuclear Receptors (Saccharomyces cerevisiae)", "d": [], "t": []}], "preferred_name": "Signaling by Nuclear Receptors (Saccharomyces cerevisiae)", "taxa": []} {"type": "biolink:Pathway", "ic": null, "identifiers": [{"i": "SMPDB:SMP0048717", "l": "Cardiolipin Biosynthesis CL(a-13:0/i-22:0/i-19:0/i-13:0),Disease", "d": [], "t": []}], "preferred_name": "Cardiolipin Biosynthesis CL(a-13:0/i-22:0/i-19:0/i-13:0),Disease", "taxa": []} {"type": "biolink:Pathway", "ic": null, "identifiers": [{"i": 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