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Glycine N-methyltransferase catalyzes the synthesis of N-methylglycine (sarcosine) from glycine using S-adenosylmethionine (AdoMet) as the methyl donor. GNMT acts as an enzyme to regulate the ratio of S-adenosylmethionine to S-adenosylhomocysteine (AdoHcy) and participates in the detoxification pathway in liver cells. A defect in this enzyme causes accumulation of methionine in the plasma and transaminases in the serum. Symptoms include hepatomegaly.", "d": [], "t": []}], "preferred_name": "Glycine N-Methyltransferase Deficiency,Disease,Glycine N-methyltransferase deficiency (GNMT deficiency) is caused by mutation in the GNMT gene (606628). Glycine N-methyltransferase catalyzes the synthesis of N-methylglycine (sarcosine) from glycine using S-adenosylmethionine (AdoMet) as the methyl donor. GNMT acts as an enzyme to regulate the ratio of S-adenosylmethionine to S-adenosylhomocysteine (AdoHcy) and participates in the detoxification pathway in liver cells. A defect in this enzyme causes accumulation of methionine in the plasma and transaminases in the serum. Symptoms include hepatomegaly.", "taxa": []} {"type": "biolink:Pathway", "ic": null, "identifiers": [{"i": "REACT:R-BTA-9707587", "l": "Regulation of HMOX1 expression and activity (Bos taurus)", "d": [], "t": []}], "preferred_name": "Regulation of HMOX1 expression and activity (Bos taurus)", "taxa": []} {"type": "biolink:Pathway", "ic": null, "identifiers": [{"i": "REACT:R-PFA-8956319", "l": "Nucleotide catabolism (Plasmodium falciparum)", "d": [], "t": []}], "preferred_name": "Nucleotide catabolism (Plasmodium falciparum)", "taxa": []} {"type": "biolink:Pathway", "ic": null, "identifiers": [{"i": "REACT:R-SSC-1483255", "l": "PI Metabolism (Sus scrofa)", "d": [], "t": []}], "preferred_name": "PI Metabolism (Sus scrofa)", "taxa": []} {"type": "biolink:Pathway", "ic": null, "identifiers": [{"i": "SMPDB:SMP0062279", "l": "Cardiolipin Biosynthesis CL(i-14:0/i-13:0/i-24:0/a-25:0),Disease", "d": [], "t": []}], "preferred_name": "Cardiolipin Biosynthesis CL(i-14:0/i-13:0/i-24:0/a-25:0),Disease", "taxa": []} {"type": "biolink:Pathway", "ic": null, "identifiers": [{"i": "SMPDB:SMP0039625", "l": "De Novo Triacylglycerol Biosynthesis TG(i-19:0/21:0/20:0),Metabolic", "d": [], "t": []}], "preferred_name": "De Novo Triacylglycerol Biosynthesis TG(i-19:0/21:0/20:0),Metabolic", "taxa": []} {"type": "biolink:Pathway", "ic": null, "identifiers": [{"i": "SMPDB:SMP0040696", "l": "De Novo Triacylglycerol Biosynthesis TG(i-20:0/i-24:0/a-25:0),Metabolic", "d": [], "t": []}], "preferred_name": "De Novo Triacylglycerol Biosynthesis TG(i-20:0/i-24:0/a-25:0),Metabolic", "taxa": []} {"type": "biolink:Pathway", "ic": null, "identifiers": [{"i": "REACT:R-CFA-111933", "l": "Calmodulin induced events (Canis familiaris)", "d": [], "t": []}], "preferred_name": "Calmodulin induced events (Canis familiaris)", "taxa": []} {"type": "biolink:Pathway", "ic": null, "identifiers": [{"i": "SMPDB:SMP0000320", "l": "Intracellular Signalling Through Adenosine Receptor A2a and Adenosine,Protein", "d": [], "t": []}], "preferred_name": "Intracellular Signalling Through Adenosine Receptor A2a and Adenosine,Protein", "taxa": []} {"type": "biolink:Pathway", "ic": null, "identifiers": [{"i": "SMPDB:SMP0058279", "l": "Cardiolipin Biosynthesis CL(i-13:0/i-16:0/a-25:0/a-15:0),Disease", "d": [], "t": []}], "preferred_name": "Cardiolipin Biosynthesis CL(i-13:0/i-16:0/a-25:0/a-15:0),Disease", "taxa": []} {"type": "biolink:Pathway", "ic": null, "identifiers": [{"i": "REACT:R-XTR-166663", "l": "Initial triggering of complement (Xenopus tropicalis)", "d": [], "t": []}], "preferred_name": "Initial triggering of complement (Xenopus tropicalis)", "taxa": []} {"type": "biolink:Pathway", "ic": null, "identifiers": [{"i": "SMPDB:SMP0042182", "l": "De Novo Triacylglycerol Biosynthesis TG(i-22:0/i-14:0/i-17:0),Metabolic", "d": [], "t": []}], "preferred_name": "De Novo Triacylglycerol Biosynthesis TG(i-22:0/i-14:0/i-17:0),Metabolic", "taxa": []} {"type": "biolink:Pathway", "ic": null, "identifiers": [{"i": "REACT:R-CEL-73886", "l": "Chromosome Maintenance (Caenorhabditis elegans)", "d": [], "t": []}], "preferred_name": "Chromosome Maintenance (Caenorhabditis elegans)", "taxa": []} {"type": "biolink:Pathway", "ic": null, "identifiers": [{"i": "SMPDB:SMP0045375", "l": "Cardiolipin Biosynthesis CL(a-13:0/i-12:0/i-12:0/i-17:0),Disease", "d": [], "t": []}], "preferred_name": "Cardiolipin Biosynthesis CL(a-13:0/i-12:0/i-12:0/i-17:0),Disease", "taxa": []} {"type": "biolink:Pathway", "ic": null, "identifiers": [{"i": "REACT:R-RNO-193368", "l": "Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol (Rattus norvegicus)", "d": [], "t": []}], "preferred_name": "Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol (Rattus norvegicus)", "taxa": []} {"type": "biolink:Pathway", "ic": null, "identifiers": [{"i": "SMPDB:SMP0031862", "l": "De Novo Triacylglycerol Biosynthesis TG(10:0/20:0/i-15:0),Metabolic", "d": [], "t": []}], "preferred_name": "De Novo Triacylglycerol Biosynthesis TG(10:0/20:0/i-15:0),Metabolic", "taxa": []} {"type": "biolink:Pathway", "ic": null, "identifiers": [{"i": "SMPDB:SMP0047730", "l": "Cardiolipin Biosynthesis CL(a-13:0/i-19:0/i-18:0/a-15:0),Disease", "d": [], "t": []}], "preferred_name": "Cardiolipin Biosynthesis CL(a-13:0/i-19:0/i-18:0/a-15:0),Disease", "taxa": []} {"type": "biolink:Pathway", "ic": null, "identifiers": [{"i": "SMPDB:SMP0022633", "l": "De Novo Triacylglycerol Biosynthesis TG(20:1(11Z)/20:0/24:1(15Z)),Metabolic", "d": [], "t": []}], "preferred_name": "De Novo Triacylglycerol Biosynthesis TG(20:1(11Z)/20:0/24:1(15Z)),Metabolic", "taxa": []} {"type": "biolink:Pathway", "ic": null, "identifiers": [{"i": "SMPDB:SMP0051449", "l": "Cardiolipin Biosynthesis CL(i-12:0/i-13:0/a-17:0/i-15:0),Disease", "d": [], "t": []}], "preferred_name": "Cardiolipin Biosynthesis CL(i-12:0/i-13:0/a-17:0/i-15:0),Disease", "taxa": []} {"type": "biolink:Pathway", "ic": null, "identifiers": [{"i": "REACT:R-DRE-373752", "l": "Netrin-1 signaling (Danio rerio)", "d": [], "t": []}], "preferred_name": "Netrin-1 signaling (Danio rerio)", "taxa": []} {"type": "biolink:Pathway", "ic": null, "identifiers": [{"i": "SMPDB:SMP0045518", "l": "Cardiolipin Biosynthesis CL(a-13:0/i-12:0/i-20:0/i-16:0),Disease", "d": [], "t": []}], "preferred_name": "Cardiolipin Biosynthesis CL(a-13:0/i-12:0/i-20:0/i-16:0),Disease", "taxa": []} {"type": "biolink:Pathway", "ic": null, "identifiers": [{"i": "REACT:R-GGA-1299503", "l": "TWIK related potassium channel (TREK) (Gallus gallus)", "d": [], "t": []}], "preferred_name": "TWIK related potassium channel (TREK) (Gallus gallus)", "taxa": []} {"type": "biolink:Pathway", "ic": null, "identifiers": [{"i": "REACT:R-HSA-5083635", "l": "Defective B3GALTL causes PpS (Homo sapiens)", "d": [], "t": []}], "preferred_name": "Defective B3GALTL causes PpS (Homo sapiens)", "taxa": []} {"type": "biolink:Pathway", "ic": null, "identifiers": [{"i": "SMPDB:SMP0052934", "l": "Cardiolipin Biosynthesis CL(i-12:0/i-17:0/i-20:0/a-25:0),Disease", "d": [], "t": []}], "preferred_name": "Cardiolipin Biosynthesis CL(i-12:0/i-17:0/i-20:0/a-25:0),Disease", "taxa": []} {"type": "biolink:Pathway", "ic": null, "identifiers": [{"i": "REACT:R-CEL-211916", "l": "Vitamins (Caenorhabditis elegans)", "d": [], "t": []}], "preferred_name": "Vitamins (Caenorhabditis elegans)", "taxa": []} {"type": "biolink:Pathway", "ic": null, "identifiers": [{"i": "REACT:R-RNO-73843", "l": "5-Phosphoribose 1-diphosphate biosynthesis (Rattus norvegicus)", "d": [], "t": []}], "preferred_name": "5-Phosphoribose 1-diphosphate biosynthesis (Rattus norvegicus)", "taxa": []} {"type": "biolink:Pathway", "ic": null, "identifiers": [{"i": "SMPDB:SMP0039693", "l": "De Novo Triacylglycerol Biosynthesis TG(i-19:0/a-21:0/i-13:0),Metabolic", "d": [], "t": []}], "preferred_name": "De Novo Triacylglycerol Biosynthesis TG(i-19:0/a-21:0/i-13:0),Metabolic", "taxa": []} {"type": "biolink:Pathway", "ic": null, "identifiers": [{"i": "REACT:R-CFA-6805567", "l": "Keratinization (Canis familiaris)", "d": [], "t": []}], "preferred_name": "Keratinization (Canis familiaris)", "taxa": []} {"type": "biolink:Pathway", "ic": null, "identifiers": [{"i": "SMPDB:SMP0000124", "l": "Glycerol Phosphate Shuttle,Metabolic,The glycerol phosphate shuttle also known as the glycerophosphate shuttle. It shuttles electrons to mitochondrial carriers in the oxidative phosphorylation pathway from cytosolic NADH. This shuttle relies on mitochondrial glycerol-3-phosphate dehydrogenase (mGPDH). This is also a common process for the cell to regenerate cytosolic NAD+ for other processes.", "d": [], "t": []}], "preferred_name": "Glycerol Phosphate Shuttle,Metabolic,The glycerol phosphate shuttle also known as the glycerophosphate shuttle. It shuttles electrons to mitochondrial carriers in the oxidative phosphorylation pathway from cytosolic NADH. This shuttle relies on mitochondrial glycerol-3-phosphate dehydrogenase (mGPDH). This is also a common process for the cell to regenerate cytosolic NAD+ for other processes.", "taxa": []} {"type": "biolink:Pathway", "ic": null, "identifiers": [{"i": "SMPDB:SMP0044838", "l": "Cardiolipin Biosynthesis CL(a-13:0/a-21:0/i-18:0/i-17:0),Disease", "d": [], "t": []}], "preferred_name": "Cardiolipin Biosynthesis CL(a-13:0/a-21:0/i-18:0/i-17:0),Disease", "taxa": []} {"type": "biolink:Pathway", "ic": null, "identifiers": [{"i": "REACT:R-DME-69186", "l": "Lagging Strand Synthesis (Drosophila melanogaster)", "d": [], "t": []}], "preferred_name": "Lagging Strand Synthesis (Drosophila melanogaster)", "taxa": []} {"type": "biolink:Pathway", "ic": null, "identifiers": [{"i": "REACT:R-HSA-442720", "l": "CREB1 phosphorylation through the activation of Adenylate Cyclase (Homo sapiens)", "d": [], "t": []}], "preferred_name": "CREB1 phosphorylation through the activation of Adenylate Cyclase (Homo sapiens)", "taxa": []} {"type": "biolink:Pathway", "ic": null, "identifiers": [{"i": "SMPDB:SMP0038606", "l": "De Novo Triacylglycerol Biosynthesis TG(a-21:0/i-19:0/a-25:0),Metabolic", "d": [], "t": []}], "preferred_name": "De Novo Triacylglycerol Biosynthesis TG(a-21:0/i-19:0/a-25:0),Metabolic", "taxa": []} {"type": "biolink:Pathway", "ic": null, "identifiers": [{"i": "SMPDB:SMP0058733", "l": "Cardiolipin Biosynthesis CL(i-13:0/i-17:0/i-18:0/i-16:0),Disease", "d": [], "t": []}], "preferred_name": "Cardiolipin Biosynthesis CL(i-13:0/i-17:0/i-18:0/i-16:0),Disease", "taxa": []} {"type": "biolink:Pathway", "ic": null, "identifiers": [{"i": "SMPDB:SMP0049716", "l": "Cardiolipin Biosynthesis CL(i-12:0/a-13:0/i-21:0/a-15:0),Disease", "d": [], "t": []}], "preferred_name": "Cardiolipin Biosynthesis CL(i-12:0/a-13:0/i-21:0/a-15:0),Disease", "taxa": []} {"type": "biolink:Pathway", "ic": null, "identifiers": [{"i": "SMPDB:SMP0060319", "l": "Cardiolipin Biosynthesis CL(i-13:0/i-22:0/i-13:0/i-20:0),Disease", "d": [], "t": []}], "preferred_name": "Cardiolipin Biosynthesis CL(i-13:0/i-22:0/i-13:0/i-20:0),Disease", "taxa": []} {"type": "biolink:Pathway", "ic": null, "identifiers": [{"i": "REACT:R-GGA-5610785", "l": "GLI3 is processed to GLI3R by the proteasome (Gallus gallus)", "d": [], "t": []}], "preferred_name": "GLI3 is processed to GLI3R by the proteasome (Gallus gallus)", "taxa": []} {"type": "biolink:Pathway", "ic": null, "identifiers": [{"i": "SMPDB:SMP0057042", "l": "Cardiolipin Biosynthesis CL(i-13:0/i-12:0/i-14:0/i-20:0),Disease", "d": [], "t": []}], "preferred_name": "Cardiolipin Biosynthesis CL(i-13:0/i-12:0/i-14:0/i-20:0),Disease", "taxa": []} {"type": "biolink:Pathway", "ic": null, "identifiers": [{"i": "REACT:R-SPO-5693532", "l": "DNA Double-Strand Break Repair (Schizosaccharomyces pombe)", "d": [], "t": []}], "preferred_name": "DNA Double-Strand Break Repair (Schizosaccharomyces pombe)", "taxa": []} {"type": "biolink:Pathway", "ic": null, "identifiers": [{"i": "REACT:R-CFA-425410", "l": "Metal ion SLC transporters (Canis familiaris)", "d": [], "t": []}], "preferred_name": "Metal ion SLC transporters (Canis familiaris)", "taxa": []} {"type": "biolink:Pathway", "ic": null, "identifiers": [{"i": "SMPDB:SMP0049618", "l": "Cardiolipin Biosynthesis CL(i-12:0/a-13:0/i-15:0/i-17:0),Disease", "d": [], "t": []}], "preferred_name": "Cardiolipin Biosynthesis CL(i-12:0/a-13:0/i-15:0/i-17:0),Disease", "taxa": []} {"type": "biolink:Pathway", "ic": null, "identifiers": [{"i": "SMPDB:SMP0058254", "l": "Cardiolipin Biosynthesis CL(i-13:0/i-16:0/a-17:0/i-19:0),Disease", "d": [], "t": []}], "preferred_name": "Cardiolipin Biosynthesis CL(i-13:0/i-16:0/a-17:0/i-19:0),Disease", "taxa": []} {"type": "biolink:Pathway", "ic": null, "identifiers": [{"i": "REACT:R-CEL-390918", "l": "Peroxisomal lipid metabolism (Caenorhabditis elegans)", "d": [], "t": []}], "preferred_name": "Peroxisomal lipid metabolism (Caenorhabditis elegans)", "taxa": []} {"type": "biolink:Pathway", "ic": null, "identifiers": [{"i": "REACT:R-BTA-9668328", "l": "Sealing of the nuclear envelope (NE) by ESCRT-III (Bos taurus)", "d": [], "t": []}], "preferred_name": "Sealing of the nuclear envelope (NE) by ESCRT-III (Bos taurus)", "taxa": []} {"type": "biolink:Pathway", "ic": null, "identifiers": [{"i": "SMPDB:SMP0052303", "l": "Cardiolipin Biosynthesis CL(i-12:0/i-15:0/i-21:0/a-15:0),Disease", "d": [], "t": []}], "preferred_name": "Cardiolipin Biosynthesis CL(i-12:0/i-15:0/i-21:0/a-15:0),Disease", "taxa": []} {"type": "biolink:Pathway", "ic": null, "identifiers": [{"i": "REACT:R-BTA-5654736", "l": "Signaling by FGFR1 (Bos taurus)", "d": [], "t": []}], "preferred_name": "Signaling by FGFR1 (Bos taurus)", "taxa": []} {"type": "biolink:Pathway", "ic": null, "identifiers": [{"i": "REACT:R-MMU-881907", "l": "Gastrin-CREB signalling pathway via PKC and MAPK (Mus musculus)", "d": [], "t": []}], "preferred_name": "Gastrin-CREB signalling pathway via PKC and MAPK (Mus musculus)", "taxa": []} {"type": "biolink:Pathway", "ic": null, "identifiers": [{"i": "REACT:R-GGA-1606322", "l": "ZBP1(DAI) mediated induction of type I IFNs (Gallus gallus)", "d": [], "t": []}], "preferred_name": "ZBP1(DAI) mediated induction of type I IFNs (Gallus gallus)", "taxa": []} {"type": "biolink:Pathway", "ic": null, "identifiers": [{"i": "REACT:R-GGA-5576893", "l": "Phase 2 - plateau phase (Gallus gallus)", "d": [], "t": []}], "preferred_name": "Phase 2 - plateau phase (Gallus gallus)", "taxa": []} {"type": "biolink:Pathway", "ic": null, "identifiers": [{"i": "SMPDB:SMP0048018", "l": "Cardiolipin Biosynthesis CL(a-13:0/i-20:0/i-16:0/a-25:0),Disease", "d": [], "t": []}], "preferred_name": "Cardiolipin Biosynthesis CL(a-13:0/i-20:0/i-16:0/a-25:0),Disease", "taxa": []} {"type": "biolink:Pathway", "ic": null, "identifiers": [{"i": "REACT:R-DRE-3000471", "l": "Scavenging by Class B Receptors (Danio rerio)", "d": [], "t": []}], "preferred_name": "Scavenging by Class B Receptors (Danio rerio)", "taxa": []} {"type": "biolink:Pathway", "ic": null, "identifiers": [{"i": "REACT:R-RNO-71240", "l": "Tryptophan catabolism (Rattus norvegicus)", "d": [], "t": []}], "preferred_name": "Tryptophan catabolism (Rattus norvegicus)", "taxa": []} {"type": "biolink:Pathway", "ic": null, "identifiers": [{"i": "SMPDB:SMP0041525", "l": "De Novo Triacylglycerol Biosynthesis TG(i-21:0/i-22:0/15:0),Metabolic", "d": [], "t": []}], "preferred_name": "De Novo Triacylglycerol Biosynthesis TG(i-21:0/i-22:0/15:0),Metabolic", "taxa": []} {"type": "biolink:Pathway", "ic": null, "identifiers": [{"i": "SMPDB:SMP0043989", "l": "Cardiolipin Biosynthesis CL(a-13:0/a-15:0/a-13:0/a-21:0),Disease", "d": [], "t": []}], "preferred_name": "Cardiolipin Biosynthesis CL(a-13:0/a-15:0/a-13:0/a-21:0),Disease", "taxa": []} {"type": "biolink:Pathway", "ic": null, "identifiers": [{"i": "SMPDB:SMP0000491", "l": "Sepiapterin Reductase Deficiency,Disease", "d": [], "t": []}], "preferred_name": "Sepiapterin Reductase Deficiency,Disease", "taxa": []} {"type": "biolink:Pathway", "ic": null, "identifiers": [{"i": "SMPDB:SMP0063402", "l": "Cardiolipin Biosynthesis CL(i-14:0/i-17:0/i-15:0/i-18:0),Disease", "d": [], "t": []}], "preferred_name": "Cardiolipin Biosynthesis CL(i-14:0/i-17:0/i-15:0/i-18:0),Disease", "taxa": []} {"type": "biolink:Pathway", "ic": null, "identifiers": [{"i": "SMPDB:SMP0063188", "l": "Cardiolipin Biosynthesis CL(i-14:0/i-16:0/i-18:0/i-24:0),Disease", "d": [], "t": []}], "preferred_name": "Cardiolipin Biosynthesis CL(i-14:0/i-16:0/i-18:0/i-24:0),Disease", "taxa": []} {"type": "biolink:Pathway", "ic": null, "identifiers": [{"i": "SMPDB:SMP0056825", "l": "Cardiolipin Biosynthesis CL(i-13:0/a-25:0/i-20:0/i-18:0),Disease", "d": [], "t": []}], "preferred_name": "Cardiolipin Biosynthesis CL(i-13:0/a-25:0/i-20:0/i-18:0),Disease", "taxa": []} {"type": "biolink:Pathway", "ic": null, "identifiers": [{"i": "SMPDB:SMP0047187", "l": "Cardiolipin Biosynthesis CL(a-13:0/i-17:0/i-24:0/i-19:0),Disease", "d": [], "t": []}], "preferred_name": "Cardiolipin Biosynthesis 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