Autologous Polyclonal Tumor Infiltrating Lymphocytes LYL845
autologous polyclonal tumor infiltrating lymphocytes lyl845
"A preparation of autologous, epigenetically reprogrammed, polyclonal tumor infiltrating lymphocytes (TILs), with potential immunomodulating and antineoplastic activities. The autologous TILs LYL845 are prepared and expanded ex vivo by co-culturing autologous tumor cells with specific Epi-R cell culture media containing optimized cytokine composition and cell activation which creates TILs enriched with CD8-positive T-cells with diverse tumor-reactive clones and an enhanced proportion of stem-like T-cells. Upon administration, the autologous TILs LYL845 may target and kill tumor cells and secrete pro-inflammatory cytokines. LYL845 shows increased durability of expanded TILs, enhanced polyclonality and increased tumor-reactive cytolytic T-cells compared to TILs derived from the standard process."