CD3+/CD19+ Cell-depleted Autologous Hematopoietic Stem Cells
cd3+/cd19+ cell-depleted autologous hematopoietic stem cells
"A preparation of autologous hematopoietic stem cells (HSCs) that have been selectively depleted of CD3-positive (CD3+) T-cells and CD19-positive (CD19+) B-cells, with potential immune reconstituting activity. Upon administration, the CD3+/CD19+ cell-depleted autologous HSCs are used for autologous stem cell transplant (ASCT) and may allow for rapid and sustained engraftment and immune reconstitution without the autoreactive CD3+ T-cells and CD19+ B-cells. This may alleviate manifestations of autoimmune diseases such as systemic lupus erythematosus (SLE) and systemic sclerosis."