Autologous GCC-targeting CAR T Cells GCC19CART
autologous gcc-targeting car t cells gcc19cart
"A preparation of autologous T-lymphocytes that are genetically engineered to express a chimeric antigen receptor (CAR) targeting the enterocyte differentiation antigen guanylyl cyclase C (GUCY2C) that are activated with CAR T-cells specific for the CD19 antigen, and coupled to as of yet not fully elucidated signaling domains, with potential immunostimulating and antineoplastic activities. Upon intravenous administration, the autologous GCC-targeting CAR T cells GCC19CART are directed to, specifically bind to, activate, proliferate and release cytokines that promote killing of GCC-expressing tumor cells. GCC is overexpressed in various tumor cell types. The activation of the GCC-targeting T-cells by activated CD19 CAR  that secrete cytokines, enhances CAR T-cell activation and proliferation,  and may increase the T-cell-mediated killing of GCC-expressing tumor cells."