TCR-engineered T-cells HRYZ-T101
tcr-engineered t-cells hryz-t101
"A preparation of genetically engineered T-lymphocytes expressing a T-cell receptor (TCR) targeting a specific tumor-associated antigen (TAA) of the human papillomavirus (HPV) type 18 (HPV-18), with potential antineoplastic activity. Upon administration, HPV-18 expressing TCR T-cells target and bind to tumor cells expressing the HPV-18 TAA leading to selective cytotoxicity in HPV-18 TAA-expressing tumor cells. HPV18 TAAs are overexpressed in a variety of tumor cell types."