PA700 Regulatory Module
pa700 regulatory module
"Ubiquitinated proteins are degraded by a 26S ATP-dependent protease complex, composed of a 20S catalytic proteasome and two 19S PA700 regulatory modules.  The multi-subunit PA700 complex binds two sites of the 20S proteasome and is composed of at least six related ATPases and approximately fifteen non-ATPase polypeptides.  Each of the ATPases, PSMC1-6, contains an AAA (ATPases associated with diverse cellular activities) domain.  A protein complex containing p42 and p50 enhances PA700 activation of the proteasome."