label: Tert-butyloxycarbonyl-Leu-Arg-7-amino-4-methylcoumarin
label_lc: tert-butyloxycarbonyl-leu-arg-7-amino-4-methylcoumarin
description: "Fluorogenic tri-peptide substrate for measuring the \"trypsin-like\" peptidase activity of the 20S proteasome. Each of the two 20S internal beta-type rings harbors three different proteolytically active sites:beta-1 (\"post-glutamyl peptide hydrolase\" site), beta-2 (\"trypsin-like\" site) and beta-5 (\"chymotrypsin-like\" site). This peptide is also substrate for the Kex2 endopeptidase from S. Cervisiae, which has substrate specificity toward the C-terminal side of LR, PR and RR sequences. In addition, the peptide can be cleaved by Kalikrein 5 with a P1 site preference for basic residues (R and K)."