label: Primary Cutaneous NUT Adnexal Carcinoma
label_lc: primary cutaneous nut adnexal carcinoma
description: "A very rare carcinoma that arises from adnexal structures in the skin. It is characterized by mutations and rearrangement of the NUT gene. It presents as a papular or nodular lesion and has been described in the hand, shoulder, trunk, and lower limb. Histologically, there is a proliferation of malignant epithelial cells in the dermis and/or subcutaneous tissue. The tumor cells display round nuclei with prominent single nucleoli. Features include the presence of small round ducts and foci of abrupt keratinization."