label: Adult-Onset Leukoencephalopathy with Axonal Spheroids and Pigmented Glia
label_lc: adult-onset leukoencephalopathy with axonal spheroids and pigmented glia
description: "A rapidly progressive neurodegenerative disorder, caused by mutations in the colony-stimulating factor 1 receptor (CSF1R) gene, that presents in adulthood with a variety of neuropsychiatric and motor disturbances. Hallmark features include diffuse myelin loss and axonal destruction, neuroaxonal spheroids, and pigmented macrophages and other glia."