label: GLI1-Altered Soft Tissue Tumor
label_lc: gli1-altered soft tissue tumor
description: "A rare mesenchymal neoplasm of uncertain histogenesis that arises from soft tissue and viscera. It is characterized by the presence of nests and sheets of neoplastic epithelioid cells separated by a rich delicate arborizing vascular network, and GLI1 gene rearrangement. It presents as a slow-growing painless mass. The majority of cases have an indolent clinical course following complete excision. Distant metastases have been reported in a minority of cases."