label: Topoisomerase II Inhibitor-Related Acute Myeloid Leukemia
label_lc: topoisomerase ii inhibitor-related acute myeloid leukemia
description: "Acute myeloid leukemias arising as a result of the mutagenic effect of therapeutic agents targeting DNA-topoisomerase II. The vast majority of patients present without a preceding myelodysplastic phase. The acute myeloid leukemias are usually of the monoblastic or myelomonocytic type. Clonal cytogenetic abnormalities are frequently present and usually involve chromosome 11q23 (MLL gene)."