label: Fumarate Hydratase-Deficient Renal Cell Carcinoma
label_lc: fumarate hydratase-deficient renal cell carcinoma
description: "A rare, highly aggressive renal cell carcinoma caused by germline or (in a subset) somatic mutation of fumarate hydratase gene. It arises mostly in the setting of hereditary leiomyomatosis-renal cell carcinoma syndrome."