label: hereditary thrombocytopenia and hematological cancer predisposition syndrome associated with RUNX1
label_lc: hereditary thrombocytopenia and hematological cancer predisposition syndrome associated with runx1
description: "This is an autosomal dominant disorder caused by mutations in the RUNX1 gene and is characterized by mild to moderate thrombocytopenia, platelet functional and/or ultrastructural defects and a predisposition to hematologic malignancies, most often AML and MDS, and less frequently T-ALL."