label: Leukocyte Adhesion Deficiency Type 3
label_lc: leukocyte adhesion deficiency type 3
description: "An autosomal recessive condition caused by mutation(s) in the FERMT3 gene, encoding fermitin family homolog 3. It is characterized by a defect in activation of all beta integrins. It manifests clinically as severe infections with marked leukocytosis, accompanied by life-threatening bleeding episodes."