label: Alpha-1 Antitrypsin Deficiency
label_lc: alpha-1 antitrypsin deficiency
description: "A genetic disorder characterized by decreased alpha-1 antitrypsin activity in the lungs and blood and deposition of alpha-1 antitrypsin protein in the hepatocytes. These abnormalities result from defective production of alpha-1 antitrypsin and lead to the development of emphysema, cirrhosis, and liver failure."