label: (S)-tetrahydrocolumbamine + reduced [NADPH--hemoprotein reductase] + O2 => (S)-canadine + oxidized [NADPH--hemoprotein reductase] + 2 H2O + H(+)
label_lc: (s)-tetrahydrocolumbamine + reduced [nadph--hemoprotein reductase] + o2 => (s)-canadine + oxidized [nadph--hemoprotein reductase] + 2 h2o + h(+)