label: 6 malonyl-CoA + 2 acetyl-CoA + 2 S-adenosyl-L-methionine + 3 H(+) => 4-O-demethylbarbatate + 2 S-adenosyl-L-homocysteine + 6 CO2 + 8 CoA + H2O
label_lc: 6 malonyl-coa + 2 acetyl-coa + 2 s-adenosyl-l-methionine + 3 h(+) => 4-o-demethylbarbatate + 2 s-adenosyl-l-homocysteine + 6 co2 + 8 coa + h2o