label: hydroxymethylglutaryl-CoA reductase (NADPH) activity
label_lc: hydroxymethylglutaryl-coa reductase (nadph) activity
description: "Catalysis of the reaction: (R)-mevalonate + CoA + 2 NADP+ = (S)-3-hydroxy-3-methylglutaryl-CoA + 2 H+ + 2 NADPH."