label: oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity
label_lc: oxidized pyrimidine nucleobase lesion dna n-glycosylase activity
description: "Catalysis of the removal oxidized pyrimidine bases by cleaving the N-C1' glycosidic bond between the oxidized pyrimidine and the deoxyribose sugar. The reaction involves formation of a covalent enzyme-pyrimidine base intermediate. Release of the enzyme and free base by a beta-elimination or a beta, gamma-elimination mechanism results in the cleavage of the DNA backbone 3' of the apyrimidinic (AP) site."