label: methylmalonate-semialdehyde dehydrogenase (acylating, NAD) activity
label_lc: methylmalonate-semialdehyde dehydrogenase (acylating, nad) activity
description: "Catalysis of the reaction: 2-methyl-3-oxopropanoate + CoA + NAD+ = propanoyl-CoA + CO2 + NADH + H+. Can also use malonate (3-oxopropanoate) as a substrate. The reaction occurs in two steps with the decarboxylation process preceding CoA-binding. Bicarbonate rather than CO2 is released as a final product."