label: (S)-tetrahydrocolumbamine + S-adenosyl-L-homocysteine + H(+) => (S)-scoulerine + S-adenosyl-L-methionine
label_lc: (s)-tetrahydrocolumbamine + s-adenosyl-l-homocysteine + h(+) => (s)-scoulerine + s-adenosyl-l-methionine