label: DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) regulator activity
label_lc: dna topoisomerase type ii (double strand cut, atp-hydrolyzing) regulator activity
description: "Binds to and modulates the activity of ATP-hydrolyzing DNA topoisomerase. DNA topoisomerase (ATP-hydrolyzing) regulator activity catalyzes a DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined; product release is coupled to ATP binding and hydrolysis; changes the linking number in multiples of 2."