label: DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
label_lc: dna topoisomerase type ii (double strand cut, atp-hydrolyzing) activity
description: "Catalysis of a DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined, driven by ATP hydrolysis. The enzyme changes the linking number in multiples of 2."