label: 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity
label_lc: 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity
description: "Catalysis of the reaction: a 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + ATP = a 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate + ADP + H+."