label: Reduced circulating alpha-1-antitrypsin concentration
label_lc: reduced circulating alpha-1-antitrypsin concentration
description: "A reduced concentration or activity of circulating alpha-1 antitrypsin, which is a 52-kDa glycoprotein mainly synthesized and secreted by hepatocytes into the bloodstream. Alpha-1 antitrypsin is a serine-proteinase inhibitor that it is crucial in maintaining protease-antiprotease homeostasis in the lungs."