label: Bacillus Calmette-Guerin Unresponsive Disease
label_lc: bacillus calmette-guerin unresponsive disease
description: "An indication that a neoplastic disease, usually non-muscle invasive bladder cancer (NMIBC), is unresponsive to bacillus Calmette-Guerin (BCG) induction therapy and that additional BCG therapy is unlikely to benefit the subject. Unresponsive subjects include those with recurrent disease within 12 months of the completion of adequate BCG therapy, recurrent high-grade disease within 6 months of the completion of adequate BCG therapy or high-grade disease at the first evaluation after a BCG induction course."