label: Reduced 3-phosphoglycerate dehydrogenase activity
label_lc: reduced 3-phosphoglycerate dehydrogenase activity
description: "Diminished activity of the enzyme 3-phosphoglycerate dehydrogenase (PGDH), which catalyzes the first step in the pathway by converting D-3-phosphoglycerate (PGA), an intermediate in glycolysis, to phosphohydroxypyruvate concomitant with the reduction of NAD+."