label: Reduced tissue delta-1-pyrroline-5-carboxylate dehydrogenase activity
label_lc: reduced tissue delta-1-pyrroline-5-carboxylate dehydrogenase activity
description: "Concentration or activity of delta-1-pyrroline-5-carboxylate dehydrogenase (P5CDH; EC 1.5.1.12) below the lower limit of normal. P5CDH can be measured in multiple tissues including leukocytes and cultured fibroblasts. P5CDH is a mitochondrial matrix NAD(+)-dependent dehydrogenase which catalyzes the second step of the proline degradation pathway, converting pyrroline-5-carboxylate to glutamate."