label: Adrenal-Restrictive HSD3B1 Genotype
label_lc: adrenal-restrictive hsd3b1 genotype
description: "A genetic finding indicating that a subject exhibits homozygous expression of adenine at position 1100 of the coding sequence of the HSD3B1 gene. This sequence encodes asparagine at amino acid residue 367 of the 3 beta-hydroxysteroid dehydrogenase/Delta 5->4-isomerase type 1 protein (steroid Delta-isomerase) and is associated with increased proteasomal degradation of steroid Delta-isomerase and a decreased rate of conversion of dehydroepiandrosterone (DHEA) to androstenedione. Expression of this form of steroid Delta-isomerase may both affect the progression of prostate and other hormone-responsive cancers and have an impact on therapeutic efficacy."