label: Ph-positive acute lymphoblastic leukemia
label_lc: ph-positive acute lymphoblastic leukemia
description: "A subset of acute lymphoblastic leukemia that results from a reciprocal translocation between the ABL-1 oncogene and a breakpoint cluster region (BCR), resulting in a fusion gene, BCR-ABL, that encodes an oncogenic protein with constitutively active tyrosine kinase activity."