label: Increased proportion autoreactive unresponsive CD21-/low B cells
label_lc: increased proportion autoreactive unresponsive cd21-/low b cells
description: "Increased proportion relative to B-lymphocytes of a subset of B lymphocytes characterized by dim/low levels of CD21, i.e., CD21-/low, in flow cytometry, and additionally enriched in autoreactive clones as determined for instance by clonse showing rheumatoid factor (anti-IgG) reactivity and antibodies recognizing cytoplasmic and to a lesser extent nuclear structures."