label: Adrenal-Permissive HSD3B1 Genotype
label_lc: adrenal-permissive hsd3b1 genotype
description: "A genetic finding indicating that a subject exhibits either homozygous or heterozygous expression of cytosine at position 1100 of the coding sequence of the HSD3B1 gene. This sequence encodes threonine at amino acid residue 367 of the 3 beta-hydroxysteroid dehydrogenase/Delta 5->4-isomerase type 1 protein (steroid Delta-isomerase) and is associated with decreased proteasomal degradation of steroid Delta-isomerase and an increased rate of conversion of dehydroepiandrosterone (DHEA) to androstenedione and more potent androgens, such as testosterone and dihydrotestosterone. Expression of this form of steroid Delta-isomerase may both affect progression of prostate and other hormone-responsive cancers and have an impact on therapeutic efficacy."