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{"type": "biolink:Cell", "ic": 87.18682603146104, "identifiers": [{"i": "UMLS:C1519600", "l": "Transformed Peripheral B-Lymphocyte", "d": [], "t": []}, {"i": "NCIT:C38658", "l": "Transformed Peripheral B-Lymphocyte", "d": ["A mature lymphocyte that has entered the peripheral blood system and has been activated into one of several mature B-cell subtypes."], "t": []}], "preferred_name": "Transformed Peripheral B-Lymphocyte", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C2333349", "l": "Retinal microglial cell", "d": [], "t": []}], "preferred_name": "Retinal microglial cell", "taxa": []}
{"type": "biolink:Cell", "ic": 87.18682603146104, "identifiers": [{"i": "CL:0002364", "l": "cortical thymic epithelial cell", "d": ["An epithelial cell of the cortical portion of the thymus. Epithelial cells in this region are required for positive selection of CD8-positive T cells."], "t": []}], "preferred_name": "cortical thymic epithelial cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4047043", "l": "type 1 submucosal plexus glia", "d": ["An enteric glial cell that is associated with neuron cell bodies within submucosal ganglia of the gastrointestinal tract. This cell is located in the submucosa, a layer of connective tissue beneath the intestinal mucosa. This cell plays a role in modulating secretomotor neuron activity and contributes to the regulation of digestive fluid secretion and absorption."], "t": []}], "preferred_name": "type 1 submucosal plexus glia", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5157326", "l": "CD16+CD56+ cells | Blood | Cell markers", "d": [], "t": []}], "preferred_name": "CD16+CD56+ cells | Blood | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5691292", "l": "Colonic M Cells", "d": [], "t": []}], "preferred_name": "Colonic M Cells", "taxa": []}
{"type": "biolink:Cell", "ic": 89.40238429118027, "identifiers": [{"i": "UMLS:C1513173", "l": "Metaplastic Glandular Cell", "d": [], "t": []}, {"i": "NCIT:C36837", "l": "Metaplastic Glandular Cell", "d": [], "t": []}], "preferred_name": "Metaplastic Glandular Cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4697025", "l": "CD27+IgD-IgM- cell", "d": [], "t": []}, {"i": "SNOMEDCT:1373241002", "l": "", "d": [], "t": []}], "preferred_name": "CD27+IgD-IgM- cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5454558", "l": "CD45 (Lymphs) cells | Lower respiratory specimen | Cell markers", "d": [], "t": []}], "preferred_name": "CD45 (Lymphs) cells | Lower respiratory specimen | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5163440", "l": "Eosinophils | Fetus | Pleural fluid | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Eosinophils | Fetus | Pleural fluid | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4322817", "l": "CD79B+ B lymphocyte", "d": [], "t": []}], "preferred_name": "CD79B+ B lymphocyte", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5170923", "l": "Leukocytes | Buffy Coat | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Leukocytes | Buffy Coat | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": 70.66959805369461, "identifiers": [{"i": "UMLS:C1709167", "l": "Neoplastic Cartilage Cell", "d": [], "t": []}, {"i": "NCIT:C48696", "l": "Neoplastic Cartilage Cell", "d": [], "t": []}], "preferred_name": "Neoplastic Cartilage Cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1267926", "l": "Lymphocyte positive for CD44 antigen", "d": [], "t": []}, {"i": "SNOMEDCT:117370000", "l": "", "d": [], "t": []}], "preferred_name": "Lymphocyte positive for CD44 antigen", "taxa": []}
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{"type": "biolink:Cell", "ic": 82.62268137420203, "identifiers": [{"i": "CL:0002149", "l": "epithelial cell of uterus", "d": ["An epithelial cell of the uterus. This cell has a mesodermal origin."], "t": []}, {"i": "UMLS:C2339921", "l": "Epithelial cell of uterus", "d": [], "t": []}], "preferred_name": "epithelial cell of uterus", "taxa": []}
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{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5216252", "l": "Lymphocytes|NCnc|Pt|Pericard fld", "d": [], "t": []}], "preferred_name": "Lymphocytes|NCnc|Pt|Pericard fld", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4323726", "l": "Trunk neural crest cell group", "d": [], "t": []}], "preferred_name": "Trunk neural crest cell group", "taxa": []}
{"type": "biolink:Cell", "ic": 74.50942324134168, "identifiers": [{"i": "CL:0001019", "l": "CD115-positive monocyte OR common dendritic progenitor", "d": [], "t": []}], "preferred_name": "CD115-positive monocyte OR common dendritic progenitor", "taxa": []}
{"type": "biolink:Cell", "ic": 70.82453858732072, "identifiers": [{"i": "CL:0000412", "l": "polyploid cell", "d": ["A cell that contains more than two haploid sets of chromosomes."], "t": []}], "preferred_name": "polyploid cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1517631", "l": "K-562", "d": [], "t": []}, {"i": "NCIT:C19437", "l": "K-562", "d": ["The continuous cell line K-562 was established by Lozzio and Lozzio from the pleural effusion of a 53-year-old female with chronic myelogenous leukemia in terminal blast crises. The K562 line is composed of undifferentiated blast cells that are rich in glycophorin and may be induced to produce fetal and embryonic hemoglobin in the presence of hemin."], "t": []}], "preferred_name": "K-562", "taxa": []}
{"type": "biolink:Cell", "ic": 76.9766555310214, "identifiers": [{"i": "UMLS:C1514440", "l": "Primitive Striated Muscle Cell", "d": [], "t": []}, {"i": "NCIT:C36949", "l": "Primitive Striated Muscle Cell", "d": [], "t": []}], "preferred_name": "Primitive Striated Muscle Cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5977368", "l": "Viable tumor cells", "d": [], "t": []}], "preferred_name": "Viable tumor cells", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5157457", "l": "CD3+CD8+ (T8 suppressor) cells | Tissue and Smears | Cell markers", "d": [], "t": []}], "preferred_name": "CD3+CD8+ (T8 suppressor) cells | Tissue and Smears | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": 77.82747199602274, "identifiers": [{"i": "CL:4023042", "l": "L6 corticothalamic-projecting glutamatergic cortical neuron", "d": ["A transcriptomically distinct corticothalamic-projecting neuron with a soma found in cortical layer 6."], "t": []}], "preferred_name": "L6 corticothalamic-projecting glutamatergic cortical neuron", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4042007", "l": "protoplasmic astrocyte", "d": ["An astrocyte with highly branched protrusions, found in neocortex layers 2-6. It is involved with the formation and elimination of synapses, glutamate clearance, modulation of synaptic functions and regulation of blood flow in response to synaptic activity."], "t": []}], "preferred_name": "protoplasmic astrocyte", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1267925", "l": "Lymphocyte positive for CD43 antigen", "d": [], "t": []}, {"i": "SNOMEDCT:117369001", "l": "", "d": [], "t": []}], "preferred_name": "Lymphocyte positive for CD43 antigen", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5170938", "l": "Leukocytes | Semen | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Leukocytes | Semen | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0002558", "l": "fibroblast of villous mesenchyme", "d": ["A fibroblast that is part of villous mesenchyme."], "t": []}], "preferred_name": "fibroblast of villous mesenchyme", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C3830333", "l": "EGFR CAR-CD3zeta-4-1BB-expressing Autologous T-Lymphocytes", "d": [], "t": []}, {"i": "NCIT:C107191", "l": "EGFR CAR-CD3zeta-4-1BB-expressing Autologous T-Lymphocytes", "d": ["Autologous human T-lymphocytes transduced with a retroviral vector encoding an anti-epidermal growth factor receptor (EGFR) chimeric T cell receptor (chimeric antigen receptor or CAR) gene coupled to the signaling domains from both CD3 zeta and CD137 (4-1BB), with potential immunostimulatory and antineoplastic activities. Upon administration, the chimeric EGFR antigen receptor-modified autologous T lymphocytes bind to the EGFR antigen on tumor cell surfaces; subsequently, EGFR-expressing tumor cells may be lysed. Following binding to EGFR, the 4-1BB co-stimulatory molecule signaling domain enhances both activation and signaling. Inclusion of the 4-1BB signaling domain may also increase the antitumor activity when compared to the inclusion of the CD3-zeta chain alone. EGFR, a receptor tyrosine kinase (RTK) overexpressed by a variety of cancer cell types, plays key roles in tumor cell proliferation and tumor angiogenesis."], "t": []}], "preferred_name": "EGFR CAR-CD3zeta-4-1BB-expressing Autologous T-Lymphocytes", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5833284", "l": "CD15 cells | Donor | Cell markers", "d": [], "t": []}], "preferred_name": "CD15 cells | Donor | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0000360", "l": "morula cell", "d": ["A cell of the early embryo at the developmental stage in which the blastomeres, resulting from repeated mitotic divisions of the fertilized ovum (zygote), form a compact cell mass."], "t": []}], "preferred_name": "morula cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0000689", "l": "myoendocrine cell", "d": ["A cell with both myofibrils and secretory granules."], "t": []}], "preferred_name": "myoendocrine cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5569915", "l": "Transitional cells.superficial", "d": [], "t": []}], "preferred_name": "Transitional cells.superficial", "taxa": []}
{"type": "biolink:Cell", "ic": 70.01422862627324, "identifiers": [{"i": "CL:0000954", "l": "small pre-B-II cell", "d": ["A small pre-B-II cell is a pre-B-II cell that is Rag1-positive, Rag2-positive, pre-BCR-negative, and BCR-negative, is not proliferating, and carries a DNA rearrangement of one or more immunoglobulin light chain genes."], "t": []}], "preferred_name": "small pre-B-II cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C4725933", "l": "Autologous PSMA-4SCAR-expressing T-cells 4SCAR-PSMA", "d": [], "t": []}, {"i": "NCIT:C150699", "l": "Autologous PSMA-4SCAR-expressing T-cells 4SCAR-PSMA", "d": ["A preparation of genetically modified autologous T-cells transduced with a replication incompetent, self-inactivating lentiviral vector expressing a fourth generation chimeric antigen receptor (4SCAR) consisting of an anti-prostate-specific membrane antigen (PSMA) single chain variable fragment (scFv) that is coupled to the costimulatory signaling domains CD28, CD137, CD27 and the zeta chain of the T-cell receptor (CD3zeta; CD3z), and is fused with the suicide gene inducible caspase 9 (iCasp9), with potential immunostimulating and antineoplastic activities. Upon administration, autologous PSMA-4SCAR-expressing T-cells 4SCAR-PSMA are directed to and induce selective toxicity in PSMA-expressing tumor cells. iCasp9 consists of a human FK506 drug-binding domain with an F36V mutation (FKBP12-F36V) linked to human caspase 9. If the administered T-cells lead to unacceptable side effects, the chemical homodimerizer AP1903 can be administered. AP1903 binds to the drug binding FKBP12-F36V domain and induces activation of caspase 9, which results in the apoptosis of the administered T-cells and enhances safety of this agent. PSMA, a tumor-associated antigen (TAA) and type II transmembrane protein, is expressed on the membrane of prostatic epithelial cells and overexpressed on prostate tumor cells. CD28, CD137 and CD27, T-cell surface-associated co-stimulatory molecules, are required for full T-cell activation and enhance both proliferation of T-cells and antitumor activity."], "t": []}], "preferred_name": "Autologous PSMA-4SCAR-expressing T-cells 4SCAR-PSMA", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1522157", "l": "Mouse Promonocyte", "d": [], "t": []}, {"i": "NCIT:C22585", "l": "Mouse Promonocyte", "d": [], "t": []}], "preferred_name": "Mouse Promonocyte", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5970201", "l": "Transplant pancreatic islet cells", "d": [], "t": []}, {"i": "SNOMEDCT:1304080003", "l": "", "d": [], "t": []}], "preferred_name": "Transplant pancreatic islet cells", "taxa": []}
{"type": "biolink:Cell", "ic": 88.20185721311867, "identifiers": [{"i": "CL:4301571", "l": "DCO Il22 Gly-Gaba_1 cerebellar neuron (Mmus)", "d": ["A cerebellar neuron of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Il22 (Mmus), Rftn1 (Mmus). Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Supertype:1141 DCO Il22 Gly-Gaba_1."], "t": []}], "preferred_name": "DCO Il22 Gly-Gaba_1 cerebellar neuron (Mmus)", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5555020", "l": "Universal Anti-CD7 CAR T Cells RD13-01", "d": [], "t": []}, {"i": "NCIT:C178419", "l": "Universal Anti-CD7 CAR T Cells RD13-01", "d": ["A preparation of universal T-lymphocytes that have been genetically engineered to express a chimeric antigen receptor (CAR) directed against the tumor-associated antigen (TAA) CD7, with potential immunostimulating and antineoplastic activities. Upon administration, universal anti-CD7 CAR T cells RD13-01 specifically recognize and bind to CD7-expressing tumor cells, resulting in specific T-cell-mediated tumor cell lysis. CD7 is a transmembrane glycoprotein expressed by T-cells and natural killer (NK) cells and their precursors. It is expressed in the majority of lymphoblastic T-cell leukemias and lymphomas and in a subset of peripheral T-cell lymphomas."], "t": []}], "preferred_name": "Universal Anti-CD7 CAR T Cells RD13-01", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4023077", "l": "bitufted neuron", "d": ["A type of interneuron that has two clusters of dendritic branches that originate directly from the soma and extend in opposite directions and axons that form a plexus which spreads widely. Compared to bipolar neurons, bitufted neurons have branching that occur close to the soma."], "t": []}], "preferred_name": "bitufted neuron", "taxa": []}
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{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:1001217", "l": "interlobulary artery smooth muscle cell", "d": ["Any smooth muscle cell that is part of some interlobular artery."], "t": []}], "preferred_name": "interlobulary artery smooth muscle cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5168979", "l": "Immature eosinophils | Blood | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Immature eosinophils | Blood | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": 89.40238429118027, "identifiers": [{"i": "CL:4042025", "l": "substantia nigra dopaminergic neuron", "d": ["A midbrain dopaminergic neuron that has its soma located in a substantia nigra. This dopaminergic neuron type is highly metabolically active and it is involved in the regulation of movement, cognition, motivation and reward. Neurodegeneration of this dopaminergic neuronal type causes loss in fine motor control in Parkinson's Disease."], "t": []}], "preferred_name": "substantia nigra dopaminergic neuron", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C6051116", "l": "iPSC-derived Natural Killer Cells NCR300", "d": [], "t": []}, {"i": "NCIT:C217326", "l": "iPSC-derived Natural Killer Cells NCR300", "d": ["A preparation of off-the-shelf (OTS), natural killer (NK) cells derived from a clonal master induced pluripotent stem cell (iPSC) line, with potential cytolytic and antineoplastic activities. Upon administration, iPSC-derived NK cells NCR300 recognize and lyse cancer cells. These cells also secrete pro-inflammatory cytokines, which further stimulate an anti-tumor immune response."], "t": []}], "preferred_name": "iPSC-derived Natural Killer Cells NCR300", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C4329680", "l": "Colony Forming Unit-Endothelial Cells", "d": [], "t": []}, {"i": "NCIT:C129679", "l": "Colony Forming Unit-Endothelial Cells", "d": ["A population of adherent cells in fibronectin-coated culture that resemble endothelial cells."], "t": []}], "preferred_name": "Colony Forming Unit-Endothelial Cells", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0011100", "l": "galanergic neuron", "d": ["Neuron that secretes the neurotransmitter galanin."], "t": []}], "preferred_name": "galanergic neuron", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0205867", "l": "Interfascicular Oligodendroglia", "d": [], "t": []}], "preferred_name": "Interfascicular Oligodendroglia", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C3176795", "l": "Blasts.cytoplasmic CD179a", "d": [], "t": []}], "preferred_name": "Blasts.cytoplasmic CD179a", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4266481", "l": "Tc-99m tagged RBC", "d": [], "t": []}], "preferred_name": "Tc-99m tagged RBC", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0002299", "l": "type-2 epithelial cell of thymus", "d": ["An epithelial cell scattered in the cortex, predominant in the outer cortex with a large pale nucleus and a prominent nucleolus."], "t": []}, {"i": "UMLS:C1183358", "l": "Type-2 epithelial cell of thymus", "d": [], "t": []}], "preferred_name": "type-2 epithelial cell of thymus", "taxa": []}
{"type": "biolink:Cell", "ic": 70.82453858732072, "identifiers": [{"i": "CL:0000103", "l": "bipolar neuron", "d": ["A type of interneuron that has two neurites, usually an axon and a dendrite, extending from opposite poles of an ovoid cell body."], "t": []}, {"i": "UMLS:C1511178", "l": "Bipolar neuron", "d": [], "t": []}, {"i": "NCIT:C13154", "l": "Bipolar Neuron", "d": ["A nerve cell with two processes."], "t": []}], "preferred_name": "bipolar neuron", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5157427", "l": "CD3 cells | XXX | Cell markers", "d": [], "t": []}], "preferred_name": "CD3 cells | XXX | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": 66.22131566187467, "identifiers": [{"i": "CL:0000077", "l": "mesothelial cell", "d": ["A flat, squamous-like epithelial cell of mesodermal origin. It forms the mesothelium, which lines the body's serous cavities including the pleural, peritoneal, and pericardial spaces. This cell plays a crucial role in synthesizing and secreting lubricants, such as glycosaminoglycans and surfactants, which minimize friction between adjacent tissues during movement."], "t": []}, {"i": "UMLS:C0225335", "l": "Mesothelial cell", "d": [], "t": []}, {"i": "NCIT:C33104", "l": "Mesothelial Cell", "d": ["A flat cell of mesenchymal origin that forms the superficial layer of the serosal membranes lining the body cavities of the abdomen and thorax."], "t": []}, {"i": "SNOMEDCT:58966000", "l": "", "d": [], "t": []}], "preferred_name": "mesothelial cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4322736", "l": "CD25+ T lymphocyte", "d": [], "t": []}], "preferred_name": "CD25+ T lymphocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 89.40238429118027, "identifiers": [{"i": "CL:0002492", "l": "strial marginal cell", "d": ["A polarized columnar cell that covesr the lateral surface of the cochlear duct, secretes potassium ions and forms a continuous sheet in contact with the endolymph; marginal cells form extensive interdigitations with the basal and intermediate cells in the normal adult stria."], "t": []}], "preferred_name": "strial marginal cell", "taxa": []}
{"type": "biolink:Cell", "ic": 78.54651317367835, "identifiers": [{"i": "CL:4030060", "l": "L2 intratelencephalic projecting glutamatergic neuron", "d": ["An intratelencephalic-projecting glutamatergic neuron with a soma found in cortical layer 2."], "t": []}], "preferred_name": "L2 intratelencephalic projecting glutamatergic neuron", "taxa": []}
{"type": "biolink:Cell", "ic": 31.1103288687742, "identifiers": [{"i": "CL:0000393", "l": "electrically responsive cell", "d": ["A cell whose function is determined by its response to an electric signal."], "t": []}], "preferred_name": "electrically responsive cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5447599", "l": "Umbilical Cord Blood-derived CD16-expressing Natural Killer Cells AB-101", "d": [], "t": []}, {"i": "NCIT:C177152", "l": "Umbilical Cord Blood-derived CD16-expressing Natural Killer Cells AB-101", "d": ["A preparation of allogeneic, off-the-shelf natural killer (NK) cells, derived from umbilical cord blood (UCB) and ex vivo-expanded, that expresses a high-affinity variant of CD16, with potential immunostimulatory and antineoplastic activities. Upon administration, UCB-derived CD16-expressing NK cells AB-101 lyse tumor cells. NK cells AB-101 also secrete pro-inflammatory cytokines, which further stimulate an anti-tumor immune response. Upon coadministration with tumor-targeting monoclonal antibodies, the Fab moiety of the antibodies bind to the tumor-associated antigens (TAAs) expressed on tumor cells and the Fc moiety of the antibodies bind to CD16 expressed on NK cells AB-101. This leads to NK cell activation, cytokine secretion and antibody-dependent cellular cytotoxicity (ADCC). CD16, also known as Fc-gamma receptor III, is normally expressed on the surface of NK cells, neutrophils, monocytes and macrophages, and plays a key role in initiating ADCC. It is often downregulated in certain cancers, thereby inhibiting the anti-tumor immune response."], "t": []}], "preferred_name": "Umbilical Cord Blood-derived CD16-expressing Natural Killer Cells AB-101", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5175149", "l": "Nucleated cells | Cerebral spinal fluid | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Nucleated cells | Cerebral spinal fluid | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0002298", "l": "type-5 epithelial cell of thymus", "d": ["A thymic epithelial cell type with low nuclear and cytoplasmic electrondensity; has a round, euchromatic nucleus and occurs in small groups at the corticomedullary junction or scattered singly in the medulla."], "t": []}, {"i": "UMLS:C1183361", "l": "Type-5 epithelial cell of thymus", "d": [], "t": []}], "preferred_name": "type-5 epithelial cell of thymus", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:2000068", "l": "pericardium fibroblast", "d": ["Any fibroblast that is part of a pericardium."], "t": []}], "preferred_name": "pericardium fibroblast", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0000251", "l": "extramedullary cell", "d": [], "t": []}], "preferred_name": "extramedullary cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1277066", "l": "Entire Sertoli cell", "d": [], "t": []}, {"i": "SNOMEDCT:367716000", "l": "", "d": [], "t": []}], "preferred_name": "Entire Sertoli cell", "taxa": []}
{"type": "biolink:Cell", "ic": 62.50865927177675, "identifiers": [{"i": "UMLS:C5985806", "l": "Malignant Muscle Cell", "d": [], "t": []}, {"i": "NCIT:C214806", "l": "Malignant Muscle Cell", "d": ["A malignant mesenchymal cell that originates from a myocyte."], "t": []}], "preferred_name": "Malignant Muscle Cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5186854", "l": "Normoblasts | Fetus | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Normoblasts | Fetus | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": 77.82747199602274, "identifiers": [{"i": "UMLS:C1514074", "l": "Neoplastic Promonocyte", "d": [], "t": []}, {"i": "NCIT:C37075", "l": "Neoplastic Promonocyte", "d": [], "t": []}], "preferred_name": "Neoplastic Promonocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 80.61184433509295, "identifiers": [{"i": "UMLS:C0682546", "l": "Acidophil cell", "d": [], "t": []}, {"i": "NCIT:C32044", "l": "Acidophilic Cell", "d": ["A cell whose cytoplasm or its granules stain with acid dyes."], "t": []}], "preferred_name": "Acidophil cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C0228090", "l": "Fibrillary astrocyte", "d": [], "t": []}, {"i": "NCIT:C32600", "l": "Fibrous Astrocyte", "d": ["A neuroglial cell of ectodermic origin having long, thin, infrequently branched cytoplasmic processes containing numerous fibrillar structures. It is found mainly in the white matter of the brain."], "t": []}, {"i": "SNOMEDCT:70357005", "l": "", "d": [], "t": []}], "preferred_name": "Fibrillary astrocyte", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4733226", "l": "CAR.CD30-expressing autologous Epstein-Barr virus-specific cytotoxic T-lymphocytes", "d": [], "t": []}], "preferred_name": "CAR.CD30-expressing autologous Epstein-Barr virus-specific cytotoxic T-lymphocytes", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C2348359", "l": "EGFRBi-Armed Autologous T Cells", "d": [], "t": []}, {"i": "NCIT:C71536", "l": "EGFRBi-Armed Autologous T Cells", "d": ["Autologous activated T cells, loaded with a bispecific antibody produced by heteroconjugation of anti-CD3 and anti-epidermal growth factor receptor (EGFR) monoclonal antibodies, with potential antineoplastic activity. Binding of EGFRBi-armed autologous activated T cells to EGFR-positive tumor cells may result in increased T cell-mediated cytotoxicity towards tumor cells expressing EGFR.  Arming activated T cells with this bispecific antibody may significantly increase T cell secretion of anti-tumor associated cytokines such as IL2, RANTES, IFN-gamma, and TNF-alpha."], "t": []}], "preferred_name": "EGFRBi-Armed Autologous T Cells", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C4764048", "l": "Anti-FL(FITC-E2) CAR T Cells", "d": [], "t": []}, {"i": "NCIT:C158099", "l": "Anti-FL(FITC-E2) CAR T Cells", "d": ["A preparation of genetically modified T-cells transduced with a replication incompetent, self-inactivating (SIN) lentiviral vector expressing a second generation chimeric antigen receptor (CAR) consisting of an anti-fluorescein (anti-FL) fluorescein isothiocyanate (FITC)-E2 single chain variable fragment (scFv), that is coupled, via an immunoglobulin G4 (IgG4) hinge-CH2(L295D)-CH3 spacer, to the costimulatory signaling molecules CD28, CD137 (4-1BB), and CD3 zeta, and linked to a truncated form of the human epidermal growth factor receptor (EGFRt), with potential immunostimulating and antineoplastic activities. Prior to the administration of anti-FL(FITC-E2) CAR T-cells, the CAR-T adaptor molecule (CAM) EC17 is administered. EC17 is a bispecific molecule that is composed of folic acid conjugated to FITC (folate-FITC). EC17 targets and binds with its folate moiety with high affinity to folate receptor (FR)-expressing tumor cells. Upon administration of the anti-FL(FITC-E2) CAR T-cells, these cells are attracted by and bind to the FITC antigen moiety of EC17. Upon binding to EC17, the T-cells induce specific tumor cell lysis, cytokine secretion, and proliferation, and activate a robust immune response against the EC17-bound, FR-expressing tumor cells. FR is overexpressed in various tumor cell types and is associated with increased leukemic cell proliferation and aggressiveness. The co-stimulatory molecules are required for full T-cell activation and enhance both proliferation of T-cells and antitumor activity. EGFRt both facilitates detection of the administered T-cells in vivo and can promote elimination of those cells following a cetuximab-induced antibody-dependent cellular cytotoxicity (ADCC) response. The reactivity of the anti-FL(FITC-E2) CAR T-cells is dependent on dosing of EC17, and therefore allows CAR T-cell activity to be controlled by dosing of EC17."], "t": []}], "preferred_name": "Anti-FL(FITC-E2) CAR T Cells", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5157439", "l": "CD3+CD4+ (T4 helper) cells | XXX | Cell markers", "d": [], "t": []}], "preferred_name": "CD3+CD4+ (T4 helper) cells | XXX | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1440053", "l": "Abnormal blood cells.CD20", "d": [], "t": []}], "preferred_name": "Abnormal blood cells.CD20", "taxa": []}
{"type": "biolink:Cell", "ic": 85.53200374075534, "identifiers": [{"i": "CL:0002082", "l": "type II cell of adrenal medulla", "d": ["A chromaffin cell of the adrenal medulla that produces epinephrine."], "t": []}, {"i": "UMLS:C1181531", "l": "Type II cell of adrenal medulla", "d": [], "t": []}], "preferred_name": "type II cell of adrenal medulla", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5216257", "l": "Macrophages|NCnc|Pt|Pericard fld", "d": [], "t": []}], "preferred_name": "Macrophages|NCnc|Pt|Pericard fld", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1440267", "l": "CD19+kappa+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:732277006", "l": "", "d": [], "t": []}], "preferred_name": "CD19+kappa+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0007008", "l": "notochordal vacuole cell", "d": ["Notochordal cell that is inner portion of the notochord and becomes vacuolated as development proceeds."], "t": []}], "preferred_name": "notochordal vacuole cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1979674", "l": "CD4+CD7-CD49d- cell", "d": [], "t": []}, {"i": "SNOMEDCT:1373216009", "l": "", "d": [], "t": []}], "preferred_name": "CD4+CD7-CD49d- cell", "taxa": []}
{"type": "biolink:Cell", "ic": 84.21065366064373, "identifiers": [{"i": "UMLS:C1514021", "l": "Neoplastic Megakaryoblast", "d": [], "t": []}, {"i": "NCIT:C37068", "l": "Neoplastic Megakaryoblast", "d": [], "t": []}], "preferred_name": "Neoplastic Megakaryoblast", "taxa": []}
{"type": "biolink:Cell", "ic": 80.27409497666227, "identifiers": [{"i": "UMLS:C1711303", "l": "Malignant Sebocyte", "d": [], "t": []}, {"i": "NCIT:C43339", "l": "Malignant Sebocyte", "d": [], "t": []}], "preferred_name": "Malignant Sebocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C3899739", "l": "CXCL12-Abundant Reticular Cell", "d": [], "t": []}, {"i": "NCIT:C114786", "l": "CXCL12-Abundant Reticular Cell", "d": ["A fibroblast that expresses high levels of stromal cell-derived factor 1 (CXCL12), secretes type III collagen and forms processes that contact those of other similar cells to form a network of reticular fibers. These cells may play a role in hematopoietic stem cell maintenance."], "t": []}], "preferred_name": "CXCL12-Abundant Reticular Cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1267844", "l": "Lymphoblast positive for CD5 antigen", "d": [], "t": []}, {"i": "SNOMEDCT:117531007", "l": "", "d": [], "t": []}], "preferred_name": "Lymphoblast positive for CD5 antigen", "taxa": []}
{"type": "biolink:Cell", "ic": 88.20185721311867, "identifiers": [{"i": "UMLS:C1709202", "l": "Neoplastic Spindle-Shaped Chondrocyte", "d": [], "t": []}, {"i": "NCIT:C53473", "l": "Neoplastic Spindle-Shaped Chondrocyte", "d": [], "t": []}], "preferred_name": "Neoplastic Spindle-Shaped Chondrocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4033002", "l": "neuroendocrine cell of epithelium of crypt of Lieberkuhn", "d": ["A(n) neuroendocrine cell that is part of a(n) epithelium of crypt of Lieberkuhn."], "t": []}], "preferred_name": "neuroendocrine cell of epithelium of crypt of Lieberkuhn", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C2924433", "l": "Intestinal goblet cell", "d": [], "t": []}], "preferred_name": "Intestinal goblet cell", "taxa": []}
{"type": "biolink:Cell", "ic": 75.2337427109536, "identifiers": [{"i": "CL:0000385", "l": "prohemocyte (sensu Nematoda and Protostomia)", "d": ["A precursor of mature hemocytes."], "t": []}], "preferred_name": "prohemocyte (sensu Nematoda and Protostomia)", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0000943", "l": "Be1 Cell", "d": ["A Be cell that facilitates development of T-helper 1 (Th1) phenotype in CD4-positive T cells, and secretes high levels of interleukin-2, tumor necrosis factor-alpha and interferon-gamma."], "t": []}], "preferred_name": "Be1 Cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4511892", "l": "Population of all schistocytes in portion of fluid", "d": [], "t": []}, {"i": "SNOMEDCT:726510009", "l": "", "d": [], "t": []}], "preferred_name": "Population of all schistocytes in portion of fluid", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5706216", "l": "Antigen-Presenting Cancer-Associated Fibroblast", "d": [], "t": []}, {"i": "NCIT:C187401", "l": "Antigen-Presenting Cancer-Associated Fibroblast", "d": ["A cancer-associated fibroblast characterized by novel expression of major histocompatibility complex class II molecules, which are capable of antigen presentation. These cells may mediate immune evasion."], "t": []}], "preferred_name": "Antigen-Presenting Cancer-Associated Fibroblast", "taxa": []}
{"type": "biolink:Cell", "ic": 66.22131566187467, "identifiers": [{"i": "CL:0002009", "l": "macrophage dendritic cell progenitor", "d": ["A progenitor cell that can give rise to plasmacytoid and myeloid dendritic cells, and to monocytes and macrophages."], "t": []}], "preferred_name": "macrophage dendritic cell progenitor", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4246839", "l": "Sacral/lumbosacral neural crest cell", "d": [], "t": []}], "preferred_name": "Sacral/lumbosacral neural crest cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5785355", "l": "Autologous UV-oHSV2-activated Peripheral Blood Mononuclear Cells", "d": [], "t": []}, {"i": "NCIT:C192652", "l": "Autologous UV-oHSV2-activated Peripheral Blood Mononuclear Cells", "d": ["A preparation of autologous peripheral blood mononuclear cells (PBMCs) activated ex vivo by ultraviolet-inactivated oncolytic herpes simplex virus type 2 (UV-oHSV2), with potential immunomodulating and antineoplastic activities. Upon reintroduction of the autologous UV-oHSV2-activated PBMCs into the patient, the activated immune cells kill tumor cells. Ex vivo UV-oHSV2 treatment induces natural killer (NK) cell proliferation and the secretion of interferon-gamma (IFNg). This leads to immune-mediated tumor cell death and the inhibition of tumor cell proliferation."], "t": []}], "preferred_name": "Autologous UV-oHSV2-activated Peripheral Blood Mononuclear Cells", "taxa": []}
{"type": "biolink:Cell", "ic": 88.20185721311867, "identifiers": [{"i": "CL:4301614", "l": "mature myelinating oligodendrocyte (Mmus)", "d": ["A mature myelinating oligodendrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Cldn11 (Mmus), Anln (Mmus). Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Supertype:1184 MOL NN_4."], "t": []}], "preferred_name": "mature myelinating oligodendrocyte (Mmus)", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C2362006", "l": "CD3+CD4-CD8-CD45+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:1373214007", "l": "", "d": [], "t": []}], "preferred_name": "CD3+CD4-CD8-CD45+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5419456", "l": "Allogeneic Adipose-derived Mesenchymal Stem Cells", "d": [], "t": []}, {"i": "NCIT:C172113", "l": "Allogeneic Adipose-derived Mesenchymal Stem Cells", "d": ["A preparation of culture expanded human allogeneic adipose-derived mesenchymal stem cells (MSCs), that can potentially be used to restore the function of the salivary gland tissue. Upon intra-glandular administration of the allogeneic adipose-derived MSCs, these MSCs are pluripotent and capable of differentiating into functional cells of salivary tissues. This may help heal and restore the function of these glands that are damaged by chemo- and/or radio-therapy. This may reduce symptoms of hyposalivation and xerostomia."], "t": []}], "preferred_name": "Allogeneic Adipose-derived Mesenchymal Stem Cells", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4687977", "l": "Orvacabtagene autoleucel", "d": [], "t": []}], "preferred_name": "Orvacabtagene autoleucel", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C4724864", "l": "Autologous mRNA-modified Anti-cMET CAR-T Cells", "d": [], "t": []}, {"i": "NCIT:C148164", "l": "Autologous mRNA-modified Anti-cMET CAR-T Cells", "d": ["A preparation of autologous, genetically-engineered T-lymphocytes that have been electroporated with an mRNA encoding a chimeric antigen receptor (CAR) consisting of an anti-human hepatocyte growth factor receptor (HGFR or cMET) single chain variable fragment (scFv), with potential antineoplastic activities. Upon administration, autologous mRNA-modified anti-cMET CAR-T cells direct T-cells to cMET-expressing tumor cells, which induces selective toxicity against cMET-expressing tumor cells and causes tumor cell lysis. cMET, a receptor tyrosine kinase overexpressed or mutated in many tumor cell types, plays a key role in cancer cell growth, survival, angiogenesis, invasion, and metastasis."], "t": []}], "preferred_name": "Autologous mRNA-modified Anti-cMET CAR-T Cells", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0000628", "l": "photosynthetic cell", "d": ["A cell that can perform photosynthesis, in which carbohydrates are synthesized from carbon dioxide and water, using light as the energy source."], "t": []}], "preferred_name": "photosynthetic cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4028002", "l": "alveolar capillary type 1 endothelial cell", "d": ["An alveolar capillary endothelial cell that is located distally to alveolar capillary type 2 endothelial cells."], "t": []}], "preferred_name": "alveolar capillary type 1 endothelial cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5171870", "l": "Macrophages | Synovial fluid | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Macrophages | Synovial fluid | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1516101", "l": "B-Prolymphocyte", "d": [], "t": []}, {"i": "NCIT:C33926", "l": "B-Prolymphocyte", "d": ["A developmental form in the B-lymphocyte series, intermediate between the B-lymphoblast and the mature B-cell."], "t": []}], "preferred_name": "B-Prolymphocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 73.37784620547062, "identifiers": [{"i": "CL:0008061", "l": "GABA-Chol neuron", "d": ["A neuron that releases both gamma-aminobutyric acid and acetylcholine as vesicular neurotransmitters.  Examples include some types of striatal interneuron."], "t": []}], "preferred_name": "GABA-Chol neuron", "taxa": []}
{"type": "biolink:Cell", "ic": 68.81370154821163, "identifiers": [{"i": "UMLS:C1519372", "l": "Glandular cell of small intestine", "d": [], "t": []}, {"i": "NCIT:C33566", "l": "Small Intestinal Glandular Cell", "d": ["A glandular cell found in the epithelium of the small intestine."], "t": []}], "preferred_name": "Glandular cell of small intestine", "taxa": []}
{"type": "biolink:Cell", "ic": 84.83823963392128, "identifiers": [{"i": "CL:0002395", "l": "Gr1-high classical monocyte", "d": ["A resident monocyte that is Gr-1 high, CD43-negative, CX3CR1-negative, CD115-positive, and B220-negative."], "t": []}], "preferred_name": "Gr1-high classical monocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "UMLS:C1514097", "l": "Neoplastic Small to Medium-Sized T-Lymphocyte with Irregular Nucleus", "d": [], "t": []}, {"i": "NCIT:C39681", "l": "Neoplastic Small to Medium-Sized T-Lymphocyte with Irregular Nucleus", "d": [], "t": []}], "preferred_name": "Neoplastic Small to Medium-Sized T-Lymphocyte with Irregular Nucleus", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0002197", "l": "inactive chief cell of parathyoid gland", "d": ["A parathyroid chief cell that is not actively secreting hormone. Contains small Golgi complexes with only a few grouped vesicles and membrane-bound secretory granules; glycogen and many lipofuscin granules abound but sacs of granular endoplasmic reticulum are rare and dispersed. In normal humans, inactive chief cells out number active chief cells in a ratio of 3-5:1."], "t": []}], "preferred_name": "inactive chief cell of parathyoid gland", "taxa": []}
{"type": "biolink:Cell", "ic": 74.93438803193563, "identifiers": [{"i": "UMLS:C1708863", "l": "Malignant Cell with Large Nucleus and Abundant Eosinophilic Cytoplasm", "d": [], "t": []}, {"i": "NCIT:C53666", "l": "Malignant Cell with Large Nucleus and Abundant Eosinophilic Cytoplasm", "d": [], "t": []}], "preferred_name": "Malignant Cell with Large Nucleus and Abundant Eosinophilic Cytoplasm", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5886266", "l": "Cells.CD34 recipient derived", "d": [], "t": []}], "preferred_name": "Cells.CD34 recipient derived", "taxa": []}
{"type": "biolink:Cell", "ic": 72.0250656653823, "identifiers": [{"i": "UMLS:C1513924", "l": "Neoplastic Acinar Cell", "d": [], "t": []}, {"i": "NCIT:C36943", "l": "Neoplastic Acinar Cell", "d": [], "t": []}], "preferred_name": "Neoplastic Acinar Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4052037", "l": "tuft cell of olfactory epithelium", "d": ["A tuft cell that is part of the olfactory epithelium, characterized by a globular body and the expression of neurogranin (Nrgn) in mice. This cell plays a crucial role in allergen recognition and regulating olfactory stem cell proliferation via TRPM5-dependent ATP sensing and cysteinyl leukotriene production. Unlike nasal respiratory tuft cells, it has low to absent expression of taste receptors, including the G protein Gα gustducin, and rarely contacts olfactory sensory neurons directly."], "t": []}], "preferred_name": "tuft cell of olfactory epithelium", "taxa": []}
{"type": "biolink:Cell", "ic": 88.20185721311867, "identifiers": [{"i": "CL:0002173", "l": "extraglomerular mesangial cell", "d": ["A cell that is a specialized type of pericyte providing structural support for the capillary loops of kidney. A flat, elongated cell with extensive fine cytoplasmic processes found outside the kidney glomerulus near the macula densa and bound laterally by afferent and efferent arterioles. Being phagocytic, this cell participates in the continuous turnover of the basal lamina by removing its outer portion containing residues of filtration, while the lamina is renewed on its inner surface by the endothelial cells."], "t": []}, {"i": "UMLS:C1517057", "l": "Extraglomerular Mesangial Cells", "d": [], "t": []}, {"i": "NCIT:C32572", "l": "Extraglomerular Mesangial Cell", "d": [], "t": []}], "preferred_name": "extraglomerular mesangial cell", "taxa": []}
{"type": "biolink:Cell", "ic": 68.42130732128746, "identifiers": [{"i": "UMLS:C1514015", "l": "Neoplastic Medium-Sized Lymphocyte", "d": [], "t": []}, {"i": "NCIT:C37004", "l": "Neoplastic Medium-Sized Lymphocyte", "d": [], "t": []}], "preferred_name": "Neoplastic Medium-Sized Lymphocyte", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5173498", "l": "Mononuclear cells | Peritoneal fluid | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Mononuclear cells | Peritoneal fluid | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0432613", "l": "Eosinophilic myeloblast", "d": [], "t": []}, {"i": "SNOMEDCT:259719000", "l": "", "d": [], "t": []}], "preferred_name": "Eosinophilic myeloblast", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1563925", "l": "Tr1 Cells", "d": [], "t": []}], "preferred_name": "Tr1 Cells", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C3495989", "l": "A3 cell group", "d": [], "t": []}], "preferred_name": "A3 cell group", "taxa": []}
{"type": "biolink:Cell", "ic": 82.62268137420203, "identifiers": [{"i": "UMLS:C1882050", "l": "Neoplastic Epithelial Oval Cell", "d": [], "t": []}, {"i": "NCIT:C60990", "l": "Neoplastic Epithelial Oval Cell", "d": [], "t": []}], "preferred_name": "Neoplastic Epithelial Oval Cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C2327597", "l": "Central neuroglial cell", "d": [], "t": []}], "preferred_name": "Central neuroglial cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1440274", "l": "CD19+CD25+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:1372978004", "l": "", "d": [], "t": []}], "preferred_name": "CD19+CD25+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4307055", "l": "Astro-OLF NN_3 Ecrg4 astrocyte (Mmus)", "d": ["A astrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of C230072F16Rik (Mmus), Dipk1c (Mmus), Ecrg4 (Mmus). It is distinguished from other Astro-OLF NN_3 cells by expression of Ecrg4. These cells are located in the Olfactory areas , in or close to the regions: Main olfactory bulb, granule layer . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5235 Astro-OLF NN_3."], "t": []}], "preferred_name": "Astro-OLF NN_3 Ecrg4 astrocyte (Mmus)", "taxa": []}
{"type": "biolink:Cell", "ic": 85.53200374075534, "identifiers": [{"i": "CL:2000097", "l": "midbrain dopaminergic neuron", "d": ["Any dopaminergic neuron that is part of a midbrain."], "t": []}], "preferred_name": "midbrain dopaminergic neuron", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1514203", "l": "Polygonal or Elongated Mononuclear Mesenchymal Cell", "d": [], "t": []}, {"i": "NCIT:C36932", "l": "Polygonal or Elongated Mononuclear Mesenchymal Cell", "d": [], "t": []}], "preferred_name": "Polygonal or Elongated Mononuclear Mesenchymal Cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0333856", "l": "Non-cleaved cell", "d": [], "t": []}, {"i": "SNOMEDCT:63584005", "l": "", "d": [], "t": []}], "preferred_name": "Non-cleaved cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0229638", "l": "Neutrophilic metamyelocyte", "d": [], "t": []}, {"i": "SNOMEDCT:50134008", "l": "", "d": [], "t": []}], "preferred_name": "Neutrophilic metamyelocyte", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0546506", "l": "P.B. reticulum cell", "d": [], "t": []}], "preferred_name": "P.B. reticulum cell", "taxa": []}
{"type": "biolink:Cell", "ic": 61.541308739176614, "identifiers": [{"i": "CL:0008000", "l": "non-striated muscle cell", "d": ["Any muscle cell in which the fibers are not organised into sarcomeres."], "t": []}], "preferred_name": "non-striated muscle cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0001025", "l": "Kit-positive, Sca1-positive common lymphoid progenitor", "d": ["A common lymphoid progenitor that is Kit-low, FLT3-positive, IL7ralpha-positive, and SCA1-low."], "t": []}], "preferred_name": "Kit-positive, Sca1-positive common lymphoid progenitor", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1440319", "l": "CD47+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:1372895008", "l": "", "d": [], "t": []}], "preferred_name": "CD47+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5706365", "l": "Autologous Anti-ROR1 CAR T-cells LYL797", "d": [], "t": []}, {"i": "NCIT:C187118", "l": "Autologous Anti-ROR1 CAR T-cells LYL797", "d": ["A preparation of genetically and epigenetically reprogrammed autologous T-lymphocytes transduced with a lentiviral vector to express a chimeric antigen receptor (CAR) targeting the receptor tyrosine kinase-like orphan receptor 1 (ROR1), with potential immunomodulatory and antineoplastic activities. After isolation, transduction, and expansion in culture, the autologous anti-ROR1 CAR T-cells LYL797 are reintroduced into the patient and are directed to tumor cells expressing ROR1, which may result in a selective toxicity against, and lysis of ROR1-expressing tumor cells. ROR1 is expressed during embryogenesis and upregulated in certain tumor types. High levels of ROR1 expression often correlate with poor prognosis. Due to the genetically and epigenetically modifications, LYL797 may overcome T-cell exhaustion and inability to self-renew. The T-cells are genetically modified to overexpress the protein c-Jun and thereby resist exhaustion and restore their anti-tumor activity. Also, the T-cells are reprogrammed to give them durable stemness and effector function."], "t": []}], "preferred_name": "Autologous Anti-ROR1 CAR T-cells LYL797", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5666969", "l": "CBL-B Inhibitor-treated Autologous Tumor-infiltrating Lymphocytes DeTIL-0255", "d": [], "t": []}, {"i": "NCIT:C185289", "l": "CBL-B Inhibitor-treated Autologous Tumor-infiltrating Lymphocytes DeTIL-0255", "d": ["A preparation of autologous tumor-infiltrating lymphocytes (TILs) derived from a patient's tumor that have been treated ex vivo during cell expansion with NX-0255, an inhibitor of Casitas B-lineage lymphoma proto-oncogene-b (CBL-B), with potential immunomodulating and antineoplastic activities. Upon administration, the CBL-B inhibitor-treated autologous TILs DeTIL-0255 specifically recognize and kill the patient's tumor cells. NX-0255 enhances TIL expansion and the tumor-killing ability of the TILs when returned to the patient."], "t": []}], "preferred_name": "CBL-B Inhibitor-treated Autologous Tumor-infiltrating Lymphocytes DeTIL-0255", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5855285", "l": "Anitocabtagene autoleucel", "d": [], "t": []}, {"i": "NCIT:C199003", "l": "Anitocabtagene Autoleucel", "d": ["A preparation of autologous T-lymphocytes that are genetically modified ex vivo and transduced with a lentiviral vector to express a D-binding domain based chimeric antigen receptor (CAR) that specifically recognizes the tumor-associated antigen (TAA) B-cell maturation antigen (BCMA; tumor necrosis factor receptor superfamily member 17; TNFRSF17) that is fused to the intracellular signaling domains of 4-1BB (CD137) and the T-cell receptor signaling domain of CD3zeta (CD3z), with potential immunostimulating and antineoplastic activities. Upon administration, anitocabtagene autoleucel specifically recognizes and induces selective toxicity in BCMA-expressing tumor cells. BCMA, a receptor for both a proliferation-inducing ligand (APRIL) and B-cell activating factor (BAFF), is a member of the tumor necrosis factor receptor superfamily (TNFRSF) and plays a key role in the survival of B-lymphocytes and plasma cells. BCMA is found on the surfaces of B-cells and is overexpressed on malignant plasma cells. The use of a synthetic D-domain protein as the antigen binding domain may allow for increased CAR density on the T-cell surface, may reduce immunogenicity, may increase CAR cell surface stability, may improve CAR T-cell function and persistence, and may increase tumor cell killing."], "t": []}], "preferred_name": "Anitocabtagene autoleucel", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0020034", "l": "stem cell memory CD8-positive, alpha-beta T cell", "d": ["A CD8-positive memory alpha-beta T cell with stem-like properties that is long-lived, retains a naïve-like phenotype, and exhibits self-renewal and multipotent differentiation capacity. This cell acts as a stem-like reservoir capable of regenerating central and effector memory T cell subsets."], "t": []}], "preferred_name": "stem cell memory CD8-positive, alpha-beta T cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5206704", "l": "Autologous Anti-gp100CAR-CD3zeta-4-1BB-IL-15-PD1-expressing Tri-functional T-lymphocytes", "d": [], "t": []}, {"i": "NCIT:C162626", "l": "Autologous Anti-gp100CAR-CD3zeta-4-1BB-IL-15-PD1-expressing Tri-functional T-lymphocytes", "d": ["A preparation of autologous T-lymphocytes that have been transduced with a lentiviral vector encoding a tri-functional chimeric antigen receptor (TriCAR) comprised of an extracellular domain consisting of an antigen binding domain specific to glycoprotein 100 (gp100) peptides 209-217 complexed with human leukocyte antigen A2 (HLA-A2), interleukin 15 (IL-15) and programmed cell death 1 (PD1; PDCD1; CD279; programmed death-1), which are linked by a transmembrane domain to the intracellular signaling domains of 4-1BB (CD137) and the zeta chain of the TCR/CD3 complex (TCRzeta; CD247; CD3zeta), with potential antineoplastic activity. Upon administration, the autologous anti-gp100CAR-CD3zeta-4-1BB-IL-15-PD1-expressing tri-functional T-lymphocytes selectively bind to gp100 peptides presented by HLA-A2. Upon binding to the gp100-HLA complex, the T-cells release cytokines and induce selective toxicity in gp100-expressing tumor cells. IL-15 is a pro-survival cytokine that promotes T-cell persistence and potentiates the immune response against tumor cells. The PD1 moiety binds to programmed cell death-1 ligand 1 (PD-L1; cluster of differentiation 274; CD274) on tumor cells, reversing T-cell inactivation caused by endogenous PD1/PD-L1 signaling and enhancing the cytotoxic T-lymphocyte (CTL)-mediated anti-tumor immune response against PD-L1-expressing tumor cells."], "t": []}], "preferred_name": "Autologous Anti-gp100CAR-CD3zeta-4-1BB-IL-15-PD1-expressing Tri-functional T-lymphocytes", "taxa": []}
{"type": "biolink:Cell", "ic": 68.20715287354084, "identifiers": [{"i": "CL:0000023", "l": "oocyte", "d": ["A female germ cell that has entered meiosis."], "t": []}, {"i": "UMLS:C0029045", "l": "Oocytes", "d": [], "t": []}, {"i": "MESH:D009865", "l": "Oocytes", "d": [], "t": []}, {"i": "SNOMEDCT:86082002", "l": "", "d": [], "t": []}], "preferred_name": "oocyte", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5780038", "l": "Autologous CD34+-enriched HSPCs Transduced with Lentiviral Vector Carrying FANCA Gene RP-L102", "d": [], "t": []}], "preferred_name": "Autologous CD34+-enriched HSPCs Transduced with Lentiviral Vector Carrying FANCA Gene RP-L102", "taxa": []}
{"type": "biolink:Cell", "ic": 25.44331356393215, "identifiers": [{"i": "CL:0000000", "l": "cell", "d": ["A material entity of anatomical origin (part of or deriving from an organism) that has as its parts a maximally connected cell compartment surrounded by a plasma membrane."], "t": []}], "preferred_name": "cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5237449", "l": "Anti-CD19-CAR-CD28/CD20-CAR-4-1BB-expressing Autologous T-lymphocytes Hu1928-Hu20BB", "d": [], "t": []}, {"i": "NCIT:C165774", "l": "Anti-CD19-CAR-CD28/CD20-CAR-4-1BB-expressing Autologous T-lymphocytes Hu1928-Hu20BB", "d": ["A preparation of autologous human T-lymphocytes that have been genetically modified to express the CAR construct Hu1928-Hu20BB that consists of two chimeric antigen receptor (CAR) constructs: one encoding a fully-human anti-CD19 CAR with a co-stimulatory domain of CD28, Hu19-CD828, and one encoding a human anti-CD20 CAR with a co-stimulatory domain of 4-1BB (CD137), Hu20BB, with potential immunostimulating and antineoplastic activities. Upon re-infusion, the anti-CD19-CAR-CD28/CD20-CAR-4-1BB-expressing autologous T-lymphocytes Hu1928-Hu20BB recognize and kill CD19- and/or CD20-expressing tumor B-cells. This results in a cytotoxic T-lymphocyte (CTL) response against CD19- and/or CD20-expressing tumor cells, thereby causing tumor cell lysis. Both the tumor-associated antigens (TAAs) CD19 and CD20 are B-cell-specific cell surface antigens overexpressed in B-cell lineage malignancies."], "t": []}], "preferred_name": "Anti-CD19-CAR-CD28/CD20-CAR-4-1BB-expressing Autologous T-lymphocytes Hu1928-Hu20BB", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1441322", "l": "Viable cells", "d": [], "t": []}], "preferred_name": "Viable cells", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4298893", "l": "Cells.CD3+CD4+CD45RO+", "d": [], "t": []}], "preferred_name": "Cells.CD3+CD4+CD45RO+", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0004119", "l": "retinal ganglion cell B1", "d": ["A retinal ganglion cell B that has medium body size, medium dendritic field and dense dendritic arbor, and has post synaptic terminals in S2."], "t": []}], "preferred_name": "retinal ganglion cell B1", "taxa": []}
{"type": "biolink:Cell", "ic": 80.96785908349635, "identifiers": [{"i": "UMLS:C1709468", "l": "Parathyroid Gland Parenchymal Cell", "d": [], "t": []}, {"i": "NCIT:C48257", "l": "Parathyroid Gland Parenchymal Cell", "d": [], "t": []}], "preferred_name": "Parathyroid Gland Parenchymal Cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C3495541", "l": "A1 noradrenaline cells", "d": [], "t": []}], "preferred_name": "A1 noradrenaline cells", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0002100", "l": "regular interventricular cardiac myocyte", "d": ["A regular cardiac myocyte of the interventricular region of the heart."], "t": []}, {"i": "UMLS:C2331714", "l": "Regular interventricular cardiac myocyte", "d": [], "t": []}], "preferred_name": "regular interventricular cardiac myocyte", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5157446", "l": "CD3+CD5- cells | Cerebral spinal fluid | Cell markers", "d": [], "t": []}], "preferred_name": "CD3+CD5- cells | Cerebral spinal fluid | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5155095", "l": "Bite cells | Blood | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Bite cells | Blood | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0000753", "l": "type 1 cone bipolar cell (sensu Mus)", "d": ["An OFF-bipolar neuron found in the retina and having connections with cone photoreceptors cells and neurons in the outer half of the inner plexiform layer. The cell body of these cells is in the middle of the inner plexiform layer. The dendritic tree is stout and the axon terminates in sublamina 1. The axonal terminal is wide and has only a few varicosities."], "t": []}], "preferred_name": "type 1 cone bipolar cell (sensu Mus)", "taxa": []}
{"type": "biolink:Cell", "ic": 73.613037951824, "identifiers": [{"i": "CL:0000878", "l": "central nervous system macrophage", "d": ["A tissue-resident macrophage found in the central nervous system."], "t": []}], "preferred_name": "central nervous system macrophage", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5669986", "l": "Autologous Anti-EGFR/Anti-IL13Ralpha2 CAR T-cells", "d": [], "t": []}, {"i": "NCIT:C185590", "l": "Autologous Anti-EGFR/Anti-IL13Ralpha2 CAR T-cells", "d": ["A preparation of autologous T-lymphocytes engineered to co-express two chimeric antigen receptors (CARs) specific for epidermal growth factor receptor (EGFR) epitope 806 and interleukin-13 receptor alpha 2 (IL13Ra2), with potential immunostimulating and antineoplastic activities. After isolation, transduction, expansion and reintroduction into the patient, the autologous anti-EGFR/anti-IL13Ra2 CAR T-cells are directed to, bind to, and induce selective toxicity in EGFR deletion mutation variant III (EGFRvIII)-expressing and IL13Ra2-expressing tumor cells. EGFRvIII, an in-frame deletion of exons 2-7 in the EGFR gene, is overexpressed by a variety of cancer cell types but absent in normal, healthy cells. It plays a key role in tumor cell proliferation, tumor angiogenesis and resistance to both radio- and chemotherapy. IL13Ra2, a cancer-associated receptor, is overexpressed by a variety of tumor cell types including glioblastoma multiforme (GBM); it is associated with increased invasiveness of tumor cells. The binding of IL13Ra2 to EGFRvIII upregulates the tyrosine kinase activity of EGFRvIII and promotes tumor cell proliferation."], "t": []}], "preferred_name": "Autologous Anti-EGFR/Anti-IL13Ralpha2 CAR T-cells", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1267833", "l": "Lymphocyte positive for both CD3 antigen and CD8 antigen", "d": [], "t": []}, {"i": "SNOMEDCT:116725004", "l": "", "d": [], "t": []}], "preferred_name": "Lymphocyte positive for both CD3 antigen and CD8 antigen", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C3826992", "l": "Immature Myeloid Cell", "d": [], "t": []}, {"i": "NCIT:C113503", "l": "Immature Myeloid Cell", "d": ["Hematopoietic cells that express the common myeloid marker CD33 but do not express the MHC class II molecule HLA-DR or other markers of mature myeloid or lymphoid cells. An accumulation of these cells may be associated with a decreased number of dendritic cells in the peripheral blood of patients with head and neck, lung or breast cancer."], "t": []}], "preferred_name": "Immature Myeloid Cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1979644", "l": "Blasts.CD30", "d": [], "t": []}], "preferred_name": "Blasts.CD30", "taxa": []}
{"type": "biolink:Cell", "ic": 72.31349143091559, "identifiers": [{"i": "UMLS:C1514146", "l": "Plasmablastic Immunoblast", "d": [], "t": []}, {"i": "NCIT:C37011", "l": "Plasmablastic Immunoblast", "d": [], "t": []}], "preferred_name": "Plasmablastic Immunoblast", "taxa": []}
{"type": "biolink:Cell", "ic": 83.11065783093733, "identifiers": [{"i": "UMLS:C1881408", "l": "Lipid-Rich Neoplastic Spindle Cell", "d": [], "t": []}, {"i": "NCIT:C61424", "l": "Lipid-Rich Neoplastic Spindle Cell", "d": [], "t": []}], "preferred_name": "Lipid-Rich Neoplastic Spindle Cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1440339", "l": "CD62L+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:1372916009", "l": "", "d": [], "t": []}], "preferred_name": "CD62L+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C2826155", "l": "2G-1 TCR Retroviral Vector-Transduced Lymphocytes", "d": [], "t": []}, {"i": "NCIT:C82408", "l": "2G-1 TCR Retroviral Vector-Transduced Lymphocytes", "d": ["A preparation of autologous human T-lymphocytes isolated from renal cell cancer (RCC) patient and transduced with 2G-1 TCR, a retroviral vector encoding the alpha and beta chains of a T-cell receptor that recognizes TNF-related apoptosis inducing ligand (TRAIL) bound to death receptor 4 (DR4), with potential immunostimulating and antineoplastic activities. After transduction, expansion in culture, and introduction into the RCC patient, 2G-1 TCR retroviral vector-transduced lymphocytes may stimulate a cytotoxic T lymphocyte (CTL) response against RCC cells with TRAIL bound to DR4 on their surfaces. TRAIL, a member of the TNF superfamily, is a homotrimeric type II membrane protein that rapidly induces oligomerization of receptor intracellular death domains and apoptosis in a variety of tumor cells when bound to its receptors; DR4 (TRAIL receptor 1), a member of the TNF receptor family, is overexpressed by a variety of malignant cell types."], "t": []}], "preferred_name": "2G-1 TCR Retroviral Vector-Transduced Lymphocytes", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1517820", "l": "Mouse Pro-T-Lymphocyte", "d": [], "t": []}, {"i": "NCIT:C22581", "l": "Mouse Pro-T-Lymphocyte", "d": [], "t": []}], "preferred_name": "Mouse Pro-T-Lymphocyte", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C6063339", "l": "CD20+CD25- cell", "d": [], "t": []}, {"i": "SNOMEDCT:1373170004", "l": "", "d": [], "t": []}], "preferred_name": "CD20+CD25- cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1522153", "l": "Mouse Monoblast", "d": [], "t": []}, {"i": "NCIT:C22584", "l": "Mouse Monoblast", "d": [], "t": []}], "preferred_name": "Mouse Monoblast", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4727630", "l": "ciltacabtagene autoleucel", "d": [], "t": []}, {"i": "SNOMEDCT:1370976008", "l": "", "d": [], "t": []}], "preferred_name": "ciltacabtagene autoleucel", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C2608015", "l": "Platelets.large", "d": [], "t": []}], "preferred_name": "Platelets.large", "taxa": []}
{"type": "biolink:Cell", "ic": 82.62268137420203, "identifiers": [{"i": "CL:4300029", "l": "cerebellar glutamatergic neuron (Mmus)", "d": ["A cerebellum glutamatergic neuron of the Mus musculus brain. Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Class:29 CB Glut."], "t": []}], "preferred_name": "cerebellar glutamatergic neuron (Mmus)", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1440281", "l": "CD3+CD4+CD45RA-CD45RO+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:1373251001", "l": "", "d": [], "t": []}], "preferred_name": "CD3+CD4+CD45RA-CD45RO+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1253961", "l": "Colligocyte", "d": [], "t": []}], "preferred_name": "Colligocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "CL:0020007", "l": "dorso-striatal cholinergic-GABAergic neuron", "d": ["A transcriptomically defined GABAergic neuron in the dorsal striatum. In mice and primates, it is defined by the coexpression of choline acetyltransferase (ChAT) together with the GABAergic markers glutamate decarboxylase 65 (GAD65/Gad2) and vesicular GABA transporter (VGAT/Slc32a1) (Lozovaya et al., 2018)."], "t": []}], "preferred_name": "dorso-striatal cholinergic-GABAergic neuron", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5185096", "l": "Viable CD34 cells | Body fluid | Cell markers", "d": [], "t": []}], "preferred_name": "Viable CD34 cells | Body fluid | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1370100", "l": "CD3+TCR alpha beta+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:1376048008", "l": "", "d": [], "t": []}], "preferred_name": "CD3+TCR alpha beta+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": 82.62268137420203, "identifiers": [{"i": "CL:0002422", "l": "enucleated reticulocyte", "d": ["A reticulocyte lacking a nucleus and showing a basophilic reticulum under vital staining due to the presence of ribosomes."], "t": []}], "preferred_name": "enucleated reticulocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:1000286", "l": "smooth muscle cell of rectum", "d": ["A smooth muscle cell that is part of the rectum."], "t": []}, {"i": "UMLS:C0736252", "l": "Smooth muscle fiber of rectum", "d": [], "t": []}], "preferred_name": "smooth muscle cell of rectum", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0003043", "l": "M10 retinal ganglion cell", "d": ["A monostratified retinal ganglion cell with large soma and large dendritic field, with dense dendritic arbor."], "t": []}], "preferred_name": "M10 retinal ganglion cell", "taxa": []}
{"type": "biolink:Cell", "ic": 80.61184433509295, "identifiers": [{"i": "CL:0011102", "l": "parasympathetic neuron", "d": ["Parasympathetic neurons are part of the parasympathetic nervous sysem and the cell bodies lie in the brain and sacral region of the spinal cord. The neurons are mainly cholinergic."], "t": []}, {"i": "UMLS:C2322797", "l": "Parasympathetic ganglion neuron", "d": [], "t": []}], "preferred_name": "parasympathetic neuron", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1517813", "l": "Mouse Leukoblast", "d": [], "t": []}, {"i": "NCIT:C22569", "l": "Mouse Leukoblast", "d": [], "t": []}], "preferred_name": "Mouse Leukoblast", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "CL:0003049", "l": "M cone cell", "d": ["A cone cell that detects medium wavelength light. Exact peak of spectra detected differs between species. In humans, spectra peaks at 534-545 nm."], "t": []}], "preferred_name": "M cone cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0017002", "l": "prostate neuroendocrine cell", "d": ["A neuroendocrine cell that is part of the prostate epithelium."], "t": []}], "preferred_name": "prostate neuroendocrine cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5170934", "l": "Leukocytes | Peritoneal fluid | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Leukocytes | Peritoneal fluid | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5170950", "l": "Leukocytes other | Blood | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Leukocytes other | Blood | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4033051", "l": "OFF parasol ganglion cell", "d": ["A parasol ganglion cell that depolarizes in response to decreased light intensity in the center of its receptive field. The majority of input that this cell receives comes from DB3a bipolar cells."], "t": []}], "preferred_name": "OFF parasol ganglion cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5783872", "l": "CD19R(EQ)-CD28-CD3zeta-EGFRt-expressing T-lymphocytes", "d": [], "t": []}, {"i": "NCIT:C190707", "l": "CD19R(EQ)-CD28-CD3zeta-EGFRt-expressing T-lymphocytes", "d": ["A preparation of genetically modified T-cells transduced expressing a chimeric antigen receptor (CAR) targeting the tumor-associated antigen (TAA) CD19 and containing the CD28 signaling domain fused to CD3 zeta, and a truncated form of the human epidermal growth factor receptor (EGFRt), with potential immunostimulating and antineoplastic activities. Upon intravenous administration, CD19R(EQ)-CD28-CD3zeta-EGFRt-expressing T-lymphocytes are directed to CD19-expressing tumor cells, thereby inducing a selective toxicity in CD19-expressing tumor cells. CD19 antigen is a B-cell specific cell surface antigen expressed in all B-cell lineage malignancies. Devoid of both ligand binding domains and tyrosine kinase activity, EGFRt both facilitates in vivo detection of the administered T-cells and can promote elimination of those cells upon a cetuximab-induced antibody dependent cellular cytotoxicity (ADCC) response. The costimulatory signaling domain enhances proliferation of T-cells and antitumor activity. CD19R(EQ) contains two-point mutations in the immunoglobulin (Ig) G4 Fc spacer region, thereby preventing recognition of the CAR by Fc gamma receptors (FcgammaRs)."], "t": []}], "preferred_name": "CD19R(EQ)-CD28-CD3zeta-EGFRt-expressing T-lymphocytes", "taxa": []}
{"type": "biolink:Cell", "ic": 92.76600187037766, "identifiers": [{"i": "CL:0002477", "l": "adipose macrophage", "d": ["A macrophage located in adipose tissue that is CD45-positive, CD11c-positive, and SIRPa-positive."], "t": []}], "preferred_name": "adipose macrophage", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C3827013", "l": "AdGMCAIX-transduced Autologous Dendritic Cells", "d": [], "t": []}, {"i": "NCIT:C105809", "l": "AdGMCAIX-transduced Autologous Dendritic Cells", "d": ["Autologous dendritic cells (DCs) transduced with a recombinant, replication-defective adenoviral vector expressing the fusion gene granulocyte-macrophage colony-stimulating factor (GM-CSF) and carbonic anhydrase IX (CA-IX or CA9) (GMCA-9), with potential immunomodulating activity. The autologous DCs are transduced ex vivo and express the GMCA-9 fusion protein on the cell surface. Upon intradermal administration of the AdGMCAIX-transduced autologous DCs back into the patient, the DCs activate the immune system to both mount a cytotoxic T lymphocyte-mediated response against tumor cells positive for the CA9 antigen, and generate memory T cells. This may result in decreased tumor growth. CA9, also known as G250, is a renal cell carcinoma (RCC)-associated antigen and a member of the carbonic anhydrase family that contains a human leukocyte antigen (HLA)-A2.1-restricted epitope; it is found in a majority of renal cell carcinomas while absent in most normal tissues. The cytokine GM-CSF enhances the immunogenicity of CA9-based DC vaccines."], "t": []}], "preferred_name": "AdGMCAIX-transduced Autologous Dendritic Cells", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0011009", "l": "embryonic plasmatocyte", "d": ["A plasmatocyte derived from the embryonic head mesoderm."], "t": []}], "preferred_name": "embryonic plasmatocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C3831562", "l": "Allogeneic Glioblastoma Stem-like Cell Line Lysate-pulsed Autologous Dendritic Cell Vaccine", "d": [], "t": []}, {"i": "NCIT:C113296", "l": "Allogeneic Glioblastoma Stem-like Cell Line Lysate-pulsed Autologous Dendritic Cell Vaccine", "d": ["A cell-based cancer vaccine composed of autologous dendritic cells (DCs) pulsed with lysates from an allogeneic glioblastoma (GBM) stem-like cell line, with potential immunostimulatory and antineoplastic activities. Upon administration allogeneic glioblastoma stem-like cell line lysate-pulsed autologous dendritic cell vaccine exposes the immune system to GBM stem cell antigens, which may result in cytotoxic T lymphocyte (CTL) and antibody responses against GBM cells. This leads to GBM cell lysis. GBM stem-like cells contain a specific range of antigens that are essential for the neoplastic growth and survival of GBM cells."], "t": []}], "preferred_name": "Allogeneic Glioblastoma Stem-like Cell Line Lysate-pulsed Autologous Dendritic Cell Vaccine", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C0229655", "l": "monoblast", "d": [], "t": []}, {"i": "NCIT:C13014", "l": "Monoblast", "d": ["A cell derived from a myeloid progenitor cell. It differentiates into a promonocyte. It is about 12 to 20 micrometer in diameter, has a round to oval nucleus with fine, lightly dispersed chromatin and one to four nucleoli. The cytoplasm is agranular, stains moderately to lightly basophilic, and often has an intensely stained periphery and a prominent perinuclear zone. Monoblasts are found in bone marrow and never appear in the normal peripheral blood."], "t": []}, {"i": "SNOMEDCT:53945006", "l": "", "d": [], "t": []}], "preferred_name": "monoblast", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C3829574", "l": "iC9-GD2-CD28-OX40-expressing T Lymphocytes", "d": [], "t": []}, {"i": "NCIT:C106123", "l": "iC9-GD2-CD28-OX40-expressing T Lymphocytes", "d": ["Modified T-lymphocytes expressing a 3rd generation chimeric antigen receptor (CAR) specific for the disialoganglioside GD2, which contains the CD3zeta chain, the signaling domains of the co-stimulatory molecules CD28 and CD134 (OX-40) and the suicide gene inducible caspase 9 (iCasp9), with potential immunomodulating and antineoplastic activities. Upon administration, iC9-GD2-CD28-OX40-expressing T lymphocytes target the GD2 antigen on tumor cells, thereby providing selective toxicity towards GD2-expressing tumor cells. iCasp9 consists of a human FK506 drug-binding domain with an F36V mutation (FKBP12-F36V) linked to human caspase 9. If the administered T cells lead to unacceptable side effects, the chemical homodimerizer AP1903 can be administered, which binds to the drug binding FKBP12-F36V domain and activates caspase 9, resulting in the apoptosis of the administered T-cells. The tumor associated antigen GD2 is overexpressed on the surface of almost all tumors of neuroectodermal origin. OX40 and CD28, both T-cell surface-associated co-stimulatory molecules, are required for full T-cell activation."], "t": []}], "preferred_name": "iC9-GD2-CD28-OX40-expressing T Lymphocytes", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4033121", "l": "lumbar ganglion VIP neuron", "d": ["A sympathetic neuron that has the soma located in the lumbar ganglion and expresses the marker vasoactive intestinal peptide (VIP)."], "t": []}], "preferred_name": "lumbar ganglion VIP neuron", "taxa": []}
{"type": "biolink:Cell", "ic": 92.76600187037766, "identifiers": [{"i": "CL:0004183", "l": "retinal ganglion cell B3", "d": ["A monostratified retinal ganglion cell with medium soma, sparse dendritic tree, and medium dendritic field."], "t": []}], "preferred_name": "retinal ganglion cell B3", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4033058", "l": "luminal hormone-sensing cell of mammary gland", "d": ["A luminal epithelial cell of the mammary gland that transduces endocrine cues to orchestrate proliferation, architectural remodeling, and differentiation of other cells in the mammary gland via paracrine signaling. This cell expresses high levels of estrogen receptors. In humans, a luminal hormone-sensing cell can be identified by high levels of EpCAM and low levels of CD49f, and in mice it can be identified by low levels of CD29 and high levels of Foxa1, CD133, and Sca1 (Ly6a)."], "t": []}], "preferred_name": "luminal hormone-sensing cell of mammary gland", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1280425", "l": "Entire alpha Cell of islet", "d": [], "t": []}, {"i": "SNOMEDCT:247770008", "l": "", "d": [], "t": []}], "preferred_name": "Entire alpha Cell of islet", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4318752", "l": "CD5+ T lymphocyte", "d": [], "t": []}], "preferred_name": "CD5+ T lymphocyte", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5184401", "l": "Unidentified cells | Synovial fluid | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Unidentified cells | Synovial fluid | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": 83.11065783093733, "identifiers": [{"i": "CL:0000507", "l": "endorphin secreting cell", "d": ["A peptide hormone secreting cell that secretes endorphin."], "t": []}], "preferred_name": "endorphin secreting cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C6064960", "l": "", "d": [], "t": []}], "preferred_name": "", "taxa": []}
{"type": "biolink:Cell", "ic": 92.76600187037766, "identifiers": [{"i": "CL:0002111", "l": "CD38-negative unswitched memory B cell", "d": ["An CD38-negative unswitched memory B cell is an unswitched memory B cell that has the phenotype CD38-negative, IgD-positive, CD138-negative, and IgG-negative."], "t": []}], "preferred_name": "CD38-negative unswitched memory B cell", "taxa": []}
{"type": "biolink:Cell", "ic": 77.38833137893549, "identifiers": [{"i": "CL:4072029", "l": "pvalb GABAergic interneuron (Homo sapiens)", "d": ["A transcriptomically distinct GABAergic interneuron with a soma located in a cerebral cortex and it expresses Parvalbumin. The standard transcriptomic reference data for this cell type can be found on the CellxGene census under the collection: 'Transcriptomic cytoarchitecture reveals principles of human neocortex organization', dataset: 'Supercluster: MGE-derived interneurons', Author Categories: 'CrossArea_subclass', cluster Pvalb."], "t": []}], "preferred_name": "pvalb GABAergic interneuron (Homo sapiens)", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4296892", "l": "Enterochromaffin cell (EC), serotonin-producing", "d": [], "t": []}], "preferred_name": "Enterochromaffin cell (EC), serotonin-producing", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "CL:0002199", "l": "oxyphil cell of parathyroid gland", "d": ["An oncocyte located in the parathyroid gland."], "t": []}, {"i": "UMLS:C0229589", "l": "Structure of parathyroid oxyphil cell", "d": [], "t": []}, {"i": "NCIT:C33269", "l": "Parathyroid Gland Oxyphil Cell", "d": ["A cell of the parathyroid gland that has condensed chromatin in a small round nucleus. Its cytoplasm is composed of tightly packed mitochondria and glycogen granules, with rare secretory granules, stains pink, and the margin is usually observed."], "t": []}, {"i": "SNOMEDCT:12701006", "l": "", "d": [], "t": []}], "preferred_name": "oxyphil cell of parathyroid gland", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1518750", "l": "Mouse Ovarian Follicular Cell", "d": [], "t": []}, {"i": "NCIT:C22661", "l": "Mouse Ovarian Follicular Cell", "d": [], "t": []}], "preferred_name": "Mouse Ovarian Follicular Cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5814406", "l": "GSK 2696273", "d": [], "t": []}], "preferred_name": "GSK 2696273", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0814996", "l": "Stomach cell", "d": [], "t": []}], "preferred_name": "Stomach cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1507178", "l": "CD8+CD95+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:1373070001", "l": "", "d": [], "t": []}], "preferred_name": "CD8+CD95+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5205974", "l": "Gene-edited Autologous Neoantigen-targeted NeoTCR-P1 T-cells", "d": [], "t": []}, {"i": "NCIT:C161651", "l": "Gene-edited Autologous Neoantigen-targeted NeoTCR-P1 T-cells", "d": ["A preparation of autologous CD4- and CD8-positive T-lymphocytes that have been engineered with site-specific nucleases to suppress the expression of most endogenous forms of the T-cell receptor (TCR) and promote expression of a single, native TCR targeting a neoepitope that is presented on the surface of a patient's tumor cells, with potential immunostimulating and antineoplastic activities. Upon reintroduction into the patient, the gene-edited autologous neoantigen-targeted NeoTCR-P1 T-cells recognize and bind to tumor cells expressing the targeted neoantigen, resulting in a cytotoxic T-lymphocyte (CTL)-mediated immune response against the patient's tumor cells."], "t": []}], "preferred_name": "Gene-edited Autologous Neoantigen-targeted NeoTCR-P1 T-cells", "taxa": []}
{"type": "biolink:Cell", "ic": 92.76600187037766, "identifiers": [{"i": "CL:0000645", "l": "pituicyte", "d": ["A glial cell of astrocytic lineage with long processes running parallel to adjacent axons in the proximal infundibulum of the neurohypophysis. These processes form a three-dimensional network among the axons of the hypothalamic neurosecretory cells and are connected by gap junctions which provide for their metabolic coupling. This cell type constitutes most of the nonexcitable tissue in the neurohypophsis; function may include possibly acting as an intermediate in the modulation of oxytocin and vasopressin release. This cell type is highly variable in size and shape and commonly contain lipid droplets and deposits of lipochrome pigment."], "t": []}], "preferred_name": "pituicyte", "taxa": []}
{"type": "biolink:Cell", "ic": 61.40866344207035, "identifiers": [{"i": "UMLS:C5856406", "l": "Autologous CAR-T Cells", "d": [], "t": []}, {"i": "NCIT:C200766", "l": "Autologous CAR-T Cells", "d": ["Autologous T-lymphocytes engineered to contain one or more chimeric antigen receptors (CARs) that specifically target one or more specific antigen(s)."], "t": []}], "preferred_name": "Autologous CAR-T Cells", "taxa": []}
{"type": "biolink:Cell", "ic": 85.53200374075534, "identifiers": [{"i": "UMLS:C5856855", "l": "Anti-HER2 CAR T Cells Preparation", "d": [], "t": []}, {"i": "NCIT:C201497", "l": "Anti-HER2 CAR T Cells Preparation", "d": ["A preparation of T-lymphocytes that express a chimeric antigen receptor (CAR) specific for the tumor-associated antigen human epidermal growth factor receptor 2 (HER2; ErbB2; HER-2)."], "t": []}], "preferred_name": "Anti-HER2 CAR T Cells Preparation", "taxa": []}
{"type": "biolink:Cell", "ic": 79.64650900338474, "identifiers": [{"i": "CL:0002431", "l": "CD4-positive, CD8-intermediate double-positive thymocyte", "d": ["A double-positive thymocyte that is undergoing positive selection, has high expression of the alpha-beta T cell receptor, is CD69-positive, and is in the process of down regulating the CD8 co-receptor."], "t": []}], "preferred_name": "CD4-positive, CD8-intermediate double-positive thymocyte", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5170958", "l": "Leukocytes other | Synovial fluid | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Leukocytes other | Synovial fluid | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0682634", "l": "Leukocyte precursor", "d": [], "t": []}], "preferred_name": "Leukocyte precursor", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "CL:0000890", "l": "M2 macrophage", "d": ["An elicited macrophage characterized by low production of pro-inflammatory and Th1 polarizing cytokines and high expression of arginase-1, and associated with tissue remodelling."], "t": []}], "preferred_name": "M2 macrophage", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4033061", "l": "endothelial cell of central vein of liver", "d": ["An endothelial cell that is part of a central vein of liver."], "t": []}], "preferred_name": "endothelial cell of central vein of liver", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0000480", "l": "secretin stimulating hormone secreting cell", "d": ["A peptide hormone secreting cell that secretes secretin stimulating hormone"], "t": []}], "preferred_name": "secretin stimulating hormone secreting cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4322668", "l": "CD3-CD16+CD56+ NK lymphocyte", "d": [], "t": []}], "preferred_name": "CD3-CD16+CD56+ NK lymphocyte", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5177777", "l": "Polymorphonuclear cells | Blood | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Polymorphonuclear cells | Blood | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": 75.70995031940328, "identifiers": [{"i": "UMLS:C1514070", "l": "Neoplastic Polygonal Cell with Eosinophilic Cytoplasm", "d": [], "t": []}, {"i": "NCIT:C37164", "l": "Neoplastic Polygonal Cell with Eosinophilic Cytoplasm", "d": [], "t": []}], "preferred_name": "Neoplastic Polygonal Cell with Eosinophilic Cytoplasm", "taxa": []}
{"type": "biolink:Cell", "ic": 72.11981073685999, "identifiers": [{"i": "UMLS:C1514271", "l": "Postgerminal Center B-Lymphocyte", "d": [], "t": []}, {"i": "NCIT:C38340", "l": "Postgerminal Center B-Lymphocyte", "d": [], "t": []}], "preferred_name": "Postgerminal Center B-Lymphocyte", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4743545", "l": "Spanlecortemlocel", "d": [], "t": []}], "preferred_name": "Spanlecortemlocel", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5157345", "l": "CD19 cells | Blood | Cell markers", "d": [], "t": []}], "preferred_name": "CD19 cells | Blood | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0333736", "l": "Alzheimer type II glial cell", "d": [], "t": []}, {"i": "SNOMEDCT:29209006", "l": "", "d": [], "t": []}], "preferred_name": "Alzheimer type II glial cell", "taxa": []}
{"type": "biolink:Cell", "ic": 64.36610274516603, "identifiers": [{"i": "UMLS:C1513940", "l": "Neoplastic Clear Cell", "d": [], "t": []}, {"i": "NCIT:C36757", "l": "Neoplastic Clear Cell", "d": [], "t": []}], "preferred_name": "Neoplastic Clear Cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5216231", "l": "Leukocytes|NCnc|Pt|Bld", "d": [], "t": []}], "preferred_name": "Leukocytes|NCnc|Pt|Bld", "taxa": []}
{"type": "biolink:Cell", "ic": 92.76600187037766, "identifiers": [{"i": "CL:4301592", "l": "Astro-TE NN_2 astrocyte (Mmus)", "d": ["A astrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Hepacam (Mmus), E330013P04Rik (Mmus). Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Supertype:1162 Astro-TE NN_2."], "t": []}], "preferred_name": "Astro-TE NN_2 astrocyte (Mmus)", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:2000077", "l": "skeletal muscle tissue of pectoralis major striated muscle cell", "d": ["Any striated muscle cell that is part of a skeletal muscle tissue of pectoralis major."], "t": []}], "preferred_name": "skeletal muscle tissue of pectoralis major striated muscle cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4323725", "l": "Cranial neural crest cell group", "d": [], "t": []}], "preferred_name": "Cranial neural crest cell group", "taxa": []}
{"type": "biolink:Cell", "ic": 72.8241867216765, "identifiers": [{"i": "UMLS:C1881560", "l": "Malignant Hyperchromatic Small Epithelial Cell", "d": [], "t": []}, {"i": "NCIT:C61588", "l": "Malignant Hyperchromatic Small Epithelial Cell", "d": [], "t": []}], "preferred_name": "Malignant Hyperchromatic Small Epithelial Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 87.18682603146104, "identifiers": [{"i": "CL:1001045", "l": "kidney cortex artery cell", "d": ["Any kidney arterial blood vessel cell that is part of some renal cortex artery."], "t": []}], "preferred_name": "kidney cortex artery cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C4524525", "l": "Derived Placental Blood Cell", "d": [], "t": []}, {"i": "NCIT:C133262", "l": "Derived Placental Blood Cell", "d": ["Cells collected from placental blood."], "t": []}], "preferred_name": "Derived Placental Blood Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 74.24062392510156, "identifiers": [{"i": "CL:0000022", "l": "female germ line stem cell", "d": ["A stem cell that is the precursor of female gametes."], "t": []}], "preferred_name": "female germ line stem cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1648297", "l": "CD38+lambda+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:1376045006", "l": "", "d": [], "t": []}], "preferred_name": "CD38+lambda+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1440317", "l": "CD45RO+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:1372893001", "l": "", "d": [], "t": []}], "preferred_name": "CD45RO+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C6056210", "l": "Unexpanded umbilical cord-derived allogeneic CD34- hematopoietic stem cells", "d": [], "t": []}], "preferred_name": "Unexpanded umbilical cord-derived allogeneic CD34- hematopoietic stem cells", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0229214", "l": "Cone cells of inner nuclear layer", "d": [], "t": []}], "preferred_name": "Cone cells of inner nuclear layer", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5908056", "l": "Autologous HLA-A*11:01 KRASG12V-specific TCR-expressing CD8- and CD4-positive T-lymphocytes AFNT-211", "d": [], "t": []}, {"i": "NCIT:C204799", "l": "Autologous HLA-A*11:01 KRASG12V-specific TCR-expressing CD8- and CD4-positive T-lymphocytes AFNT-211", "d": ["A preparation of autologous HLA class I histocompatibility antigen A*11:01 (HLA-A1101)-positive CD8- and CD4-positive T-lymphocytes that have been transduced with a lentiviral vector expressing a HLA-A*11:01-restricted T-cell receptor (TCR) that recognizes the glycine to valine point mutation at position 12 (G12V) variant of Kirsten rat sarcoma (K-RAS; KRAS), and enhanced with the wildtype CD8alpha/beta (CD8a/b) coreceptor, and a FAS-41BB switch receptor, and subsequently expanded ex vivo, with potential immunomodulating and antineoplastic activities. When reintroduced into the patient, the autologous HLA-A*11:01 KRASG12V-specific TCR-expressing CD8- and CD4-positive T-lymphocytes AFNT-211 specifically recognize and bind to KRASG12V expressed on tumor cells, which results in both cytokine secretion and cell lysis in tumor cells overexpressing KRASG12V. K-RAS, a member of the RAS family of oncogenes, serves an important role in cell signaling, division and differentiation. The KRASG12V mutation is overexpressed in a variety of cancer cell types. Mutation of K-RAS may induce constitutive signal transduction leading to tumor cell growth, proliferation, invasion, and metastasis. CD8a/b coreceptor and a FAS-41BB switch receptor improve T-cell persistence. The introduction of the CD8a/b coreceptor enables a coordinated CD4+/CD8+ T-cell response and enables CD4+ T-cell recognition of KRASG12V and enhances cytotoxicity. FAS-41BB converts the FAS ligand (FASL) tumor microenvironment (TME) death signal into a costimulatory signal through 41BB activation, thereby enhancing the durability of the anti-tumor immune response against FASL-expressing tumor cells."], "t": []}], "preferred_name": "Autologous HLA-A*11:01 KRASG12V-specific TCR-expressing CD8- and CD4-positive T-lymphocytes AFNT-211", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5690104", "l": "Cells.CD4.Tumor necrosis factor alfa-expressing", "d": [], "t": []}], "preferred_name": "Cells.CD4.Tumor necrosis factor alfa-expressing", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5170930", "l": "Leukocytes | Fetus | Pleural fluid | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Leukocytes | Fetus | Pleural fluid | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5156214", "l": "Burr cells | Cerebral spinal fluid | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Burr cells | Cerebral spinal fluid | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4033167", "l": "pelvic ganglion TH neuron", "d": ["A sympathetic neuron that has the soma located in the pelvic ganglion and expresses the marker tyrosine hydroxylase (TH)."], "t": []}], "preferred_name": "pelvic ganglion TH neuron", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0005015", "l": "inner phalangeal cell", "d": ["An auditory epithelial support cell that surrounds the nerve fibers and synapses of the auditory inner hair cells."], "t": []}, {"i": "UMLS:C1512788", "l": "Inner phalangeal cell of cochlea", "d": [], "t": []}, {"i": "NCIT:C32812", "l": "Inner Supporting Cell", "d": ["A tall, slender cell extending from the basilar membrane to the free surface of the organ of Corti. Each cell surrounds an inner hair cell."], "t": []}], "preferred_name": "inner phalangeal cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1440299", "l": "CD35+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:1372873009", "l": "", "d": [], "t": []}], "preferred_name": "CD35+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0002124", "l": "CD27-positive gamma-delta T cell", "d": ["A circulating gamma-delta T cell that is CD27-positive and capable of producing IFN-gamma."], "t": []}], "preferred_name": "CD27-positive gamma-delta T cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5170941", "l": "Leukocytes | Synovial fluid | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Leukocytes | Synovial fluid | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5554875", "l": "Bulk Cell Specimen", "d": [], "t": []}, {"i": "NCIT:C178223", "l": "Bulk Cell Specimen", "d": ["A biospecimen consisting of multiple cells intended to be analyzed as a pool."], "t": []}], "preferred_name": "Bulk Cell Specimen", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5555575", "l": "Autologous MAGE-C2-specific HLA-A2-restricted TCR T-lymphocytes", "d": [], "t": []}, {"i": "NCIT:C179275", "l": "Autologous MAGE-C2-specific HLA-A2-restricted TCR T-lymphocytes", "d": ["A preparation of autologous T-lymphocytes genetically modified to express a T-cell receptor (TCR) specific for human leukocyte antigen (HLA)-A2-restricted, melanoma-associated antigen C2 (MAGE-C2; MC2), ALK epitope, with potential antineoplastic activity. Peripheral blood mononuclear cells (PBMCs) are isolated from a patient, transduced with an anti-MAGE-C2-HLA-A2 restricted TCR, expanded ex vivo, and reintroduced into the HLA-A2-positive patient. Upon reintroduction, the autologous MAGE-C2-specific HLA-A2-restricted TCR T-lymphocytes bind to tumor cells expressing the MAGE-C2 antigen, which may induce cell death in and halt the growth of MAGE-C2-expressing cancer cells. MAGE-C2, a cancer/testis tumor-associated antigen (CT-TAA), is overexpressed by a variety of cancer cell types."], "t": []}], "preferred_name": "Autologous MAGE-C2-specific HLA-A2-restricted TCR T-lymphocytes", "taxa": []}
{"type": "biolink:Cell", "ic": 89.40238429118027, "identifiers": [{"i": "CL:0000508", "l": "type G enteroendocrine cell", "d": ["An endocrine cell found in the stomach and duodenum and is responsible for the secretion of gastrin and enkephalin. Most abundant in pyloric antrum, pyramidal in form with a narrow apex bearing long microvilli."], "t": []}], "preferred_name": "type G enteroendocrine cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:1000282", "l": "smooth muscle fiber of ascending colon", "d": ["A smooth muscle cell that is part of the ascending colon."], "t": []}, {"i": "UMLS:C0736248", "l": "Smooth muscle fiber of ascending colon", "d": [], "t": []}], "preferred_name": "smooth muscle fiber of ascending colon", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C4086612", "l": "Multi-glioblastoma-peptide-targeting Autologous Dendritic Cell Vaccine ICT-107", "d": [], "t": []}, {"i": "NCIT:C124054", "l": "Multi-glioblastoma-peptide-targeting Autologous Dendritic Cell Vaccine ICT-107", "d": ["A cell-based cancer vaccine composed of autologous dendritic cells (DCs) pulsed with six synthetic glioblastoma (GBM) peptides: absent in melanoma 2 (AIM-2), melanoma-associated antigen 1 (MAGE-1), tyrosinase-related protein 2 (TRP-2), glycoprotein 100 (gp100), epidermal growth factor receptor 2 (HER-2), interleukin-13 receptor subunit alpha-2 (IL-13Ra2), with potential immunostimulatory and antineoplastic activities. Mononuclear cells obtained via leukapheresis are differentiated into DCs, and pulsed with the GBM-associated peptides. Upon administration, multi-glioblastoma-peptide-targeting autologous DC vaccine ICT-107 exposes the immune system to GBM-associated antigens, which activates a specific cytotoxic T-lymphocyte (CTL) response against GBM cells. This leads to GBM cell lysis. The six peptides are derived from tumor associated antigens (TAA) expressed on GBM cells and cancer stem cells (CSCs). GBM stem-like cells contain a specific range of antigens that are essential for the neoplastic growth and survival of GBM cells."], "t": []}], "preferred_name": "Multi-glioblastoma-peptide-targeting Autologous Dendritic Cell Vaccine ICT-107", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5555728", "l": "Allogeneic CD19-CAR CD45RA-negative T-cells", "d": [], "t": []}, {"i": "NCIT:C179501", "l": "Allogeneic CD19-CAR CD45RA-negative T-cells", "d": ["A preparation of allogeneic T-lymphocytes, depleted of CD45RA-positive cells, that have been genetically modified to express a chimeric antigen receptor (CAR) targeting the tumor-associated antigen (TAA) CD19 (cluster of differentiation 19) fused to the co-stimulatory domain of 4-1BB (CD137) and the CD3-zeta (CD3z) T-cell signaling domain (4-1BBz), with potential immunostimulating and antineoplastic activities. CD45RA depletion results in a cellular product that contains a high amount of memory T-cells (Tm). Upon administration, the allogeneic CD19-CAR CD45RA-negative T-cells specifically recognize and bind to CD19-expressing tumor cells. This may result in a specific cytotoxic T-lymphocyte (CTL)-mediated killing of CD19-expressing tumor cells. CD19 antigen is a B-cell specific cell surface antigen overexpressed in B-cell lineage malignancies. CD45RA is expressed on naive T-cells (Tn), whereas Tm cells are CD45RA-negative. The depletion of the CD45RA-positive cells reduces the risk of graft-versus-host disease (GvHD) upon infusion. Tn cells have the potential to induce more severe graft-versus-host disease (GvHD) than Tm cells."], "t": []}], "preferred_name": "Allogeneic CD19-CAR CD45RA-negative T-cells", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5157647", "l": "CD69 cells | Blood | Cell markers", "d": [], "t": []}], "preferred_name": "CD69 cells | Blood | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": 92.76600187037766, "identifiers": [{"i": "CL:4301597", "l": "Astro-OLF NN_2 astrocyte (Mmus)", "d": ["A astrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Gja1 (Mmus), Hs3st3a1 (Mmus), Slco1c1 (Mmus). Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Supertype:1167 Astro-OLF NN_2."], "t": []}], "preferred_name": "Astro-OLF NN_2 astrocyte (Mmus)", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4085944", "l": "ATIR101", "d": [], "t": []}], "preferred_name": "ATIR101", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0229661", "l": "Myelomonoblast", "d": [], "t": []}, {"i": "SNOMEDCT:88978008", "l": "", "d": [], "t": []}], "preferred_name": "Myelomonoblast", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0546502", "l": "P.B. megakaryocyte", "d": [], "t": []}], "preferred_name": "P.B. megakaryocyte", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5157301", "l": "CD135 blasts | Bone marrow | Cell markers", "d": [], "t": []}], "preferred_name": "CD135 blasts | Bone marrow | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0001058", "l": "plasmacytoid dendritic cell, human", "d": ["A plasmacytoid dendritic cell with the phenotype HLA-DRA-positive, CD123-positive, CD11c-negative, and CD14-negative."], "t": []}], "preferred_name": "plasmacytoid dendritic cell, human", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5181479", "l": "Spherocytes | Blood cord | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Spherocytes | Blood cord | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": 85.53200374075534, "identifiers": [{"i": "UMLS:C0039748", "l": "theca cell", "d": [], "t": []}, {"i": "NCIT:C12572", "l": "Theca Cell", "d": ["An endocrine cell located in the ovary that functions to produce androgens for estrogen biosynthesis and provide structural support during oocyte maturation."], "t": []}, {"i": "MESH:D013799", "l": "Theca Cells", "d": [], "t": []}], "preferred_name": "theca cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0376448", "l": "Jurkat Cells", "d": [], "t": []}, {"i": "MESH:D019169", "l": "Jurkat Cells", "d": [], "t": []}], "preferred_name": "Jurkat Cells", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C3896582", "l": "Ex Vivo-activated Autologous Lymph Node Lymphocytes", "d": [], "t": []}, {"i": "NCIT:C114985", "l": "Ex Vivo-activated Autologous Lymph Node Lymphocytes", "d": ["Autologous human lymph node T-lymphocytes, with potential immunostimulatory and antineoplastic activity. Upon collection of immune cells from the tumor-draining lymph node, the human lymph node lymphocytes are activated with anti-CD3/anti-CD28 microbeads, cultured with recombinant, human interleukin-2 (IL-2), expanded and isolated ex vivo. Upon reintroduction into the patient, the ex vivo-activated autologous lymph node lymphocytes recognize and lyse the tumor cells."], "t": []}], "preferred_name": "Ex Vivo-activated Autologous Lymph Node Lymphocytes", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1440400", "l": "Cells.t(11;19)(q23;p13.3)(MLL,MLLT1)", "d": [], "t": []}], "preferred_name": "Cells.t(11;19)(q23;p13.3)(MLL,MLLT1)", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5418966", "l": "Anti-CD37-CAR-expressing T-lymphocytes", "d": [], "t": []}, {"i": "NCIT:C171034", "l": "Anti-CD37-CAR-expressing T-lymphocytes", "d": ["A preparation of T-lymphocytes that have been genetically modified to express a chimeric antigen receptor (CAR) targeting the tumor-associated antigen (TAA) CD37 (cluster of differentiation 37), with potential immunostimulating and antineoplastic activities. Upon administration, anti-CD37-CAR T-cells specifically recognize and kill CD37-expressing tumor cells. CD37, a member of the tetraspanin superfamily of cell surface antigens, is expressed in B-cell non-Hodgkin lymphomas (NHL), in chronic lymphocytic leukemia (CLL), and in some cases of cutaneous and peripheral T-cell lymphomas. It plays a key role in tumor cell proliferation."], "t": []}], "preferred_name": "Anti-CD37-CAR-expressing T-lymphocytes", "taxa": []}
{"type": "biolink:Cell", "ic": 79.07356789860069, "identifiers": [{"i": "CL:1000426", "l": "chromaffin cell of adrenal gland", "d": ["A chromaffin cell that is part of the adrenal gland."], "t": []}, {"i": "UMLS:C1181966", "l": "Chromaffin cell of adrenal gland", "d": [], "t": []}], "preferred_name": "chromaffin cell of adrenal gland", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1440403", "l": "Cells.t(12;16)(q13;p11.2)(DDIT3,FUS)", "d": [], "t": []}], "preferred_name": "Cells.t(12;16)(q13;p11.2)(DDIT3,FUS)", "taxa": []}
{"type": "biolink:Cell", "ic": 73.85694246010084, "identifiers": [{"i": "UMLS:C1514106", "l": "Neoplastic Syncytiotrophoblastic Cell", "d": [], "t": []}, {"i": "NCIT:C36906", "l": "Neoplastic Syncytiotrophoblastic Cell", "d": [], "t": []}], "preferred_name": "Neoplastic Syncytiotrophoblastic Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0000888", "l": "lymph node tingible body macrophage", "d": ["A lymph node macrophage found in the cortex of lymph nodes, in particular in and around the germinal centers, and that participates in phagocytosis of apoptotic B cells from the germinal centers."], "t": []}], "preferred_name": "lymph node tingible body macrophage", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4033088", "l": "decidual resident macrophage", "d": ["A resident macrophage that is part of the decidua. Some decidual macrophages are derived from maternal blood monocytes that are recruited to the uterus shortly after conception. The main functions of a decidual macrophage are implantation, placental development, immune regulation and vascular remodeling."], "t": []}], "preferred_name": "decidual resident macrophage", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1183327", "l": "Mesothelial cell of visceral peritoneum", "d": [], "t": []}], "preferred_name": "Mesothelial cell of visceral peritoneum", "taxa": []}
{"type": "biolink:Cell", "ic": 87.18682603146104, "identifiers": [{"i": "CL:0000974", "l": "long lived plasma cell", "d": ["A fully differentiated plasma cell that lives for years, as opposed to months, secretes immunoglobulin, and has the phenotype weakly CD19-positive, CD20-negative, CD38-negative, strongly CD138-positive, MHC Class II-negative, surface immunoglobulin-negative, IgD-negative, and strongly CXCR4-positive. The majority of these cells of this type reside in the bone marrow."], "t": []}], "preferred_name": "long lived plasma cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5978258", "l": "Tubular cells|Urine/Urine sed", "d": [], "t": []}], "preferred_name": "Tubular cells|Urine/Urine sed", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5549475", "l": "Spermatozoa Agglutinated | Urine | Fertility testing", "d": [], "t": []}], "preferred_name": "Spermatozoa Agglutinated | Urine | Fertility testing", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0333844", "l": "Flaming plasma cell", "d": [], "t": []}, {"i": "SNOMEDCT:81739009", "l": "", "d": [], "t": []}], "preferred_name": "Flaming plasma cell", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "CL:0002091", "l": "primary polar body", "d": ["A small cell formed by the first meiotic division of oocytes."], "t": []}, {"i": "UMLS:C0227883", "l": "First polar body", "d": [], "t": []}, {"i": "SNOMEDCT:17863007", "l": "", "d": [], "t": []}], "preferred_name": "primary polar body", "taxa": []}
{"type": "biolink:Cell", "ic": 90.871710685482, "identifiers": [{"i": "CL:0002050", "l": "fraction C' precursor B cell", "d": ["A pre-BCR-positive precursor B cell that is CD24-high, CD25-positive, CD43-positive, CD45R-positive and BP-positive."], "t": []}], "preferred_name": "fraction C' precursor B cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4722512", "l": "Allogeneic T-Lymphocytes BPX-501", "d": [], "t": []}], "preferred_name": "Allogeneic T-Lymphocytes BPX-501", "taxa": []}
{"type": "biolink:Cell", "ic": 70.74661260254285, "identifiers": [{"i": "UMLS:C1513967", "l": "Neoplastic Fibrohistiocytic Cell", "d": [], "t": []}, {"i": "NCIT:C36962", "l": "Neoplastic Fibrohistiocytic Cell", "d": [], "t": []}], "preferred_name": "Neoplastic Fibrohistiocytic Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5985944", "l": "Autologous Anti-FGFR4 CAR T-cells", "d": [], "t": []}, {"i": "NCIT:C215004", "l": "Autologous Anti-FGFR4 CAR T-cells", "d": ["A preparation of autologous T-lymphocytes that have been genetically engineered to express a chimeric antigen receptor (CAR) targeting human fibroblast growth factor receptor 4 (FGFR4), with potential immunostimulating and antineoplastic activities. Upon administration, autologous anti-FGFR4 CAR T-cells recognize and induce selective toxicity in FGFR4-expressing tumor cells. FGFR4, a receptor tyrosine kinase, is involved in angiogenesis and in the proliferation, differentiation, and survival of tumor cells."], "t": []}], "preferred_name": "Autologous Anti-FGFR4 CAR T-cells", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0002270", "l": "type EC2 enteroendocrine cell", "d": ["A type EC enteroendocrine cell in the duodenum and jejunum that stores and secretes motilin and 5-hydroxytryptamine."], "t": []}, {"i": "UMLS:C2337445", "l": "Type EC2 enteroendocrine cell", "d": [], "t": []}], "preferred_name": "type EC2 enteroendocrine cell", "taxa": []}
{"type": "biolink:Cell", "ic": 84.21065366064373, "identifiers": [{"i": "CL:0000745", "l": "retina horizontal cell", "d": ["A neuron that laterally connects other neurons in the inner nuclear layer of the retina."], "t": []}], "preferred_name": "retina horizontal cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4033046", "l": "ON midget ganglion cell", "d": ["A midget ganglion cell that depolarizes in response to increased light intensity in the center of its receptive field. The majority of input that this cell receives comes from invaginating midget bipolar cells."], "t": []}], "preferred_name": "ON midget ganglion cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1440148", "l": "Blasts.CD5", "d": [], "t": []}], "preferred_name": "Blasts.CD5", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5170920", "l": "Leukocytes | Body fluid | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Leukocytes | Body fluid | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5908865", "l": "Allogeneic NKG2D CAR Memory T-cells", "d": [], "t": []}, {"i": "NCIT:C202937", "l": "Allogeneic NKG2D CAR Memory T-cells", "d": ["A preparation of donor-derived memory T-lymphocytes that have been genetically modified to express a chimeric antigen receptor (CAR) encoding human natural-killer group 2, member D receptor protein (NKG2D or KLRK1), with potential antineoplastic activity. Upon administration, the allogeneic NKG2D CAR memory T-cells specifically recognize and bind to tumor cells expressing NKG2D ligands (NKG2DLs), resulting in cytokine secretion and lysis of NKG2D ligand-expressing tumor cells. NKG2DLs, such as MICA, MICB, and members of the UL16-binding proteins (ULBP)/retinoic acid early transcript 1 (RAET1) family, are overexpressed on a variety of cancer cell types, but are not expressed on most normal, healthy cells."], "t": []}], "preferred_name": "Allogeneic NKG2D CAR Memory T-cells", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1267834", "l": "Lymphocyte positive for both CD3 antigen and DR antigen", "d": [], "t": []}, {"i": "SNOMEDCT:117524008", "l": "", "d": [], "t": []}], "preferred_name": "Lymphocyte positive for both CD3 antigen and DR antigen", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0596108", "l": "antibody dependent killer cell", "d": [], "t": []}], "preferred_name": "antibody dependent killer cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0002330", "l": "undifferentiated cell of bronchus epithelium", "d": ["An undifferentiated columnar cell of the bronchus epithelium"], "t": []}], "preferred_name": "undifferentiated cell of bronchus epithelium", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0000428", "l": "yolk cell", "d": [], "t": []}], "preferred_name": "yolk cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5426957", "l": "Epithelial cells.ciliated | Lower respiratory specimen | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Epithelial cells.ciliated | Lower respiratory specimen | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5420484", "l": "Autologous Anti-EGFR CAR-transduced CXCR 5-modified T-lymphocytes", "d": [], "t": []}, {"i": "NCIT:C173958", "l": "Autologous Anti-EGFR CAR-transduced CXCR 5-modified T-lymphocytes", "d": ["A preparation of autologous, C-X-C chemokine receptor type 5 (CXCR 5)-modified T-lymphocytes that have been genetically modified to express a chimeric antigen receptor (CAR) targeting the epidermal growth factor receptor (EGFR), with potential immunostimulating and antineoplastic activities. Upon administration, the autologous anti-EGFR CAR-transduced CXCR 5-modified T-lymphocytes target and bind to EGFR-expressing tumor cells, thereby inducing selective toxicity in EGFR-expressing tumor cells. EGFR, overexpressed by a variety of cancer cell types, plays a key role in tumor cell proliferation, tumor angiogenesis and radio- and chemoresistance. CXCR5, and its ligand C-X-C motif chemokine 13 (CXCL13), are associated with a variety of tumors. CXCR5-CXCL13 interactions may be involved in the regulation of lymphocyte infiltration within the tumor microenvironment (TME)."], "t": []}], "preferred_name": "Autologous Anti-EGFR CAR-transduced CXCR 5-modified T-lymphocytes", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "CL:0000661", "l": "distal tip cell (sensu Nematoda)", "d": [], "t": []}], "preferred_name": "distal tip cell (sensu Nematoda)", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5157560", "l": "CD40 cells | Blood | Cell markers", "d": [], "t": []}], "preferred_name": "CD40 cells | Blood | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": 80.61184433509295, "identifiers": [{"i": "CL:0002328", "l": "bronchial epithelial cell", "d": ["An epithelial cell of the bronchus."], "t": []}], "preferred_name": "bronchial epithelial cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4322734", "l": "FMC-7+ B lymphocyte", "d": [], "t": []}], "preferred_name": "FMC-7+ B lymphocyte", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5213149", "l": "Cells with cytogenetic abnormality | Blood or Tissue | Molecular pathology", "d": [], "t": []}], "preferred_name": "Cells with cytogenetic abnormality | Blood or Tissue | Molecular pathology", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1519010", "l": "Mesothelial cell of peritoneum", "d": [], "t": []}, {"i": "NCIT:C33310", "l": "Peritoneal Mesothelial Cell", "d": [], "t": []}], "preferred_name": "Mesothelial cell of peritoneum", "taxa": []}
{"type": "biolink:Cell", "ic": 52.62701568026207, "identifiers": [{"i": "CL:0000786", "l": "plasma cell", "d": ["A terminally differentiated, post-mitotic, antibody secreting cell of the B cell lineage with the phenotype CD138-positive, surface immunonoglobulin-negative, and MHC Class II-negative. Plasma cells are oval or round with extensive rough endoplasmic reticulum, a well-developed Golgi apparatus, and a round nucleus having a characteristic cartwheel heterochromatin pattern and are devoted to producing large amounts of immunoglobulin."], "t": []}, {"i": "UMLS:C0032112", "l": "Plasma Cells", "d": [], "t": []}, {"i": "NCIT:C12486", "l": "Plasma Cell", "d": ["A fully mature B-Cell that produces a specific antibody."], "t": []}, {"i": "MESH:D010950", "l": "Plasma Cells", "d": [], "t": []}, {"i": "SNOMEDCT:113335003", "l": "", "d": [], "t": []}], "preferred_name": "plasma cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5187118", "l": "Variant lymphocytes | Fetus | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Variant lymphocytes | Fetus | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0002120", "l": "CD24-positive CD38-negative IgG-negative class switched memory B cell", "d": ["An CD24-positive CD38-negative IgG-negative memory B cell is a CD38-negative IgG-negative class switched memory B cell that lacks IgG on the cell surface with the phenotype CD24-positive, CD38-negative, and IgG-negative."], "t": []}], "preferred_name": "CD24-positive CD38-negative IgG-negative class switched memory B cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4033091", "l": "glycinergic-GABAergic amacrine cell", "d": ["An amacrine cell that uses both GABA and glycine as neurotransmitters."], "t": []}], "preferred_name": "glycinergic-GABAergic amacrine cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C3852949", "l": "V1-Derived Interneurons", "d": [], "t": []}], "preferred_name": "V1-Derived Interneurons", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C6063909", "l": "CD4-CD8-CD45+TCR alpha beta+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:1376053003", "l": "", "d": [], "t": []}], "preferred_name": "CD4-CD8-CD45+TCR alpha beta+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": 64.22073991339282, "identifiers": [{"i": "UMLS:C1514038", "l": "Neoplastic Myeloid Blast", "d": [], "t": []}, {"i": "NCIT:C37067", "l": "Neoplastic Myeloid Blast", "d": ["A neoplastic immature cell of myeloid lineage that gives rise to acute myeloid leukemias."], "t": []}], "preferred_name": "Neoplastic Myeloid Blast", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1440229", "l": "Cells.aneuploid.population 1", "d": [], "t": []}], "preferred_name": "Cells.aneuploid.population 1", "taxa": []}
{"type": "biolink:Cell", "ic": 88.20185721311867, "identifiers": [{"i": "CL:0000793", "l": "CD4-positive, alpha-beta intraepithelial T cell", "d": ["A CD4-positive, alpha-beta T cell that is found in the columnar epithelium of the gastrointestinal tract."], "t": []}], "preferred_name": "CD4-positive, alpha-beta intraepithelial T cell", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "UMLS:C1709181", "l": "Neoplastic Lactotroph Cell with Small Secretory Granules", "d": [], "t": []}, {"i": "NCIT:C45953", "l": "Neoplastic Lactotroph Cell with Small Secretory Granules", "d": [], "t": []}], "preferred_name": "Neoplastic Lactotroph Cell with Small Secretory Granules", "taxa": []}
{"type": "biolink:Cell", "ic": 88.20185721311867, "identifiers": [{"i": "CL:0000577", "l": "type EC enteroendocrine cell", "d": ["A subtype of enteroendocrine cells found in the gastrointestinal mucosa, particularly in the glands of pyloric antrum; duodenum; and ileum. These cell type secretes serotonin and some neurotransmitters including enkephalins and substance P. Their secretory granules stain readily with silver (argentaffin stain)."], "t": []}], "preferred_name": "type EC enteroendocrine cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1979240", "l": "Blasts.CD36", "d": [], "t": []}], "preferred_name": "Blasts.CD36", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C2953664", "l": "Type D enteroendocrine cell of epithelium proper of ileum", "d": [], "t": []}], "preferred_name": "Type D enteroendocrine cell of epithelium proper of ileum", "taxa": []}
{"type": "biolink:Cell", "ic": 73.85694246010084, "identifiers": [{"i": "UMLS:C1516399", "l": "Cerebriform Lymphocyte", "d": [], "t": []}, {"i": "NCIT:C39621", "l": "Cerebriform Lymphocyte", "d": [], "t": []}], "preferred_name": "Cerebriform Lymphocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C4684890", "l": "Autologous Anti-CD19 Chimeric Antigen Receptor T-cells SJCAR19", "d": [], "t": []}, {"i": "NCIT:C142887", "l": "Autologous Anti-CD19 Chimeric Antigen Receptor T-cells SJCAR19", "d": ["A proprietary preparation of autologous T-lymphocytes that have been genetically modified to express a chimeric antigen receptor (CAR) targeting the tumor-associated antigen (TAA) CD19 and containing, as of yet undisclosed, costimulatory signaling domains, with potential immunostimulating and antineoplastic activities. Upon administration, autologous anti-CD19 CAR T-cells SJCAR19 target and bind to CD19-expressing tumor cells, thereby inducing selective toxicity in CD19-expressing tumor cells. CD19 antigen is a B-cell specific cell surface antigen expressed in all B-cell lineage malignancies."], "t": []}], "preferred_name": "Autologous Anti-CD19 Chimeric Antigen Receptor T-cells SJCAR19", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5163741", "l": "Erythrocytes.dysmorphic | Urine | Urinalysis", "d": [], "t": []}], "preferred_name": "Erythrocytes.dysmorphic | Urine | Urinalysis", "taxa": []}
{"type": "biolink:Cell", "ic": 85.53200374075534, "identifiers": [{"i": "CL:0000116", "l": "pioneer neuron", "d": ["Pioneer neurons establish a pathway in the developing central nervous system and then undergo programmed cell death once the adult axons, which follow them, have made connections with the target site. Thus, they are a transient cell type involved in axon guidance."], "t": []}], "preferred_name": "pioneer neuron", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0945932", "l": "CD42+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:1372885001", "l": "", "d": [], "t": []}], "preferred_name": "CD42+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4047051", "l": "small intestine BEST4+ enterocyte", "d": ["An enterocyte of the human small intestine expressing bestrophin-4 (BEST4) calcium-activated ion channels.  These enterocytes have a disinctive transcriptomic profile and are scattered through the small intestine epithelium."], "t": []}], "preferred_name": "small intestine BEST4+ enterocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 83.63771255585968, "identifiers": [{"i": "CL:0002045", "l": "fraction A pre-pro B cell", "d": ["A pro-B cell that is CD45R/B220-positive, CD43-positive, HSA-low, BP-1-negative and Ly6c-negative. This cell type is also described as being lin-negative, AA4-positive, Kit-positive, IL7Ra-positive and CD45R-positive."], "t": []}], "preferred_name": "fraction A pre-pro B cell", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "UMLS:C3896693", "l": "Bone Marrow-Derived Cell", "d": [], "t": []}, {"i": "NCIT:C116388", "l": "Bone Marrow-Derived Cell", "d": ["A cell that is isolated from bone marrow."], "t": []}], "preferred_name": "Bone Marrow-Derived Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 59.65659525613382, "identifiers": [{"i": "UMLS:C1513932", "l": "Neoplastic Blast", "d": [], "t": []}, {"i": "NCIT:C37064", "l": "Neoplastic Blast", "d": ["A neoplastic immature myeloid or lymphoid cell that gives rise to acute myeloid leukemias or acute lymphoblastic leukemias, respectively."], "t": []}], "preferred_name": "Neoplastic Blast", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1440048", "l": "Abnormal blood cells.CD10", "d": [], "t": []}], "preferred_name": "Abnormal blood cells.CD10", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "CL:0001050", "l": "effector CD8-positive, alpha-beta T cell", "d": ["A CD8-positive, alpha-beta T cell with the phenotype CCR7-negative, CD45RA-positive."], "t": []}], "preferred_name": "effector CD8-positive, alpha-beta T cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0002333", "l": "neural crest derived adipocyte", "d": ["An adipocyte derived from a neural crest cell."], "t": []}], "preferred_name": "neural crest derived adipocyte", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1267952", "l": "Lymphocyte positive for CD61 antigen", "d": [], "t": []}, {"i": "SNOMEDCT:117393006", "l": "", "d": [], "t": []}], "preferred_name": "Lymphocyte positive for CD61 antigen", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0038856", "l": "Suppressor T Lymphocyte", "d": [], "t": []}, {"i": "SNOMEDCT:50146007", "l": "", "d": [], "t": []}], "preferred_name": "Suppressor T Lymphocyte", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5157611", "l": "CD55 Granulocytes | Blood | Cell markers", "d": [], "t": []}], "preferred_name": "CD55 Granulocytes | Blood | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4033178", "l": "dorsal root ganglion Nav1.7 neuron", "d": ["A sensory neuron that has the soma located in the dorsal root ganglion and expresses the marker sodium channel protein type 9 subunit alpha (Nav1.7/SCN9A). Nav1.7 accounts for approximately 50% of total sodium channel expression in human DRG and is present in 54-57% of TrkA-positive nociceptors."], "t": []}], "preferred_name": "dorsal root ganglion Nav1.7 neuron", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0003002", "l": "G1 retinal ganglion cell", "d": ["A retinal ganglion cell that has a small dendritic field and a medium dendritic arbor with post sympatic terminals in sublaminar layer S3."], "t": []}], "preferred_name": "G1 retinal ganglion cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C6064628", "l": "CyIg+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:1376050000", "l": "", "d": [], "t": []}], "preferred_name": "CyIg+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": 84.83823963392128, "identifiers": [{"i": "CL:1000334", "l": "enterocyte of epithelium of small intestine", "d": ["An enterocyte that is part of the epithelium of small intestine."], "t": []}, {"i": "UMLS:C2332843", "l": "Enterocyte of epithelium of small intestine", "d": [], "t": []}], "preferred_name": "enterocyte of epithelium of small intestine", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0002244", "l": "squamous cell of ectocervix", "d": ["A stratified squamous epithelial cell located in the ectocervix."], "t": []}, {"i": "UMLS:C1512166", "l": "Squamous cell of ectocervix", "d": [], "t": []}, {"i": "NCIT:C33915", "l": "Ectocervical Squamous Cell", "d": ["A flat, scale-like epithelial cell that lines the vaginal portion of cervix."], "t": []}], "preferred_name": "squamous cell of ectocervix", "taxa": []}
{"type": "biolink:Cell", "ic": 77.60424150429895, "identifiers": [{"i": "CL:0000596", "l": "sexual spore", "d": ["A spore formed following meiosis. Sometimes following meiosis, prospores may undergo one or more rounds of mitosis before they are fully mature."], "t": []}, {"i": "UMLS:C2247894", "l": "sexual sporulation", "d": [], "t": []}], "preferred_name": "sexual spore", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0444641", "l": "Synovial fluid cells", "d": [], "t": []}, {"i": "SNOMEDCT:264380007", "l": "", "d": [], "t": []}], "preferred_name": "Synovial fluid cells", "taxa": []}
{"type": "biolink:Cell", "ic": 73.26332733876373, "identifiers": [{"i": "CL:0000172", "l": "somatostatin secreting cell", "d": ["Any secretory cell that is capable of some somatostatin secretion."], "t": []}], "preferred_name": "somatostatin secreting cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1440363", "l": "CD86+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:1372939003", "l": "", "d": [], "t": []}], "preferred_name": "CD86+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0000504", "l": "enterochromaffin-like cell", "d": ["A enteroendocrine cell part of the glands of the gastric mucosa. They produce histamine and peptides such as chromogranins. This cell type respond to gastrin by releasing histamine which acts as a paracrine stimulator of the release of hydrochloric acid from the gastric parietal cells."], "t": []}, {"i": "UMLS:C0524980", "l": "Enterochromaffin-like Cells", "d": [], "t": []}, {"i": "NCIT:C12576", "l": "Enterochromaffin-Like Cell", "d": ["A type of enteroendocrine cell located in the oxyntic glands of the stomach that releases histamine in regulation of acid secretion. It is morphologically similar to enterochromaffin cells, but lacks an affinity to binding silver salts."], "t": []}, {"i": "MESH:D019861", "l": "Enterochromaffin-like Cells", "d": [], "t": []}, {"i": "SNOMEDCT:14099006", "l": "", "d": [], "t": []}], "preferred_name": "enterochromaffin-like cell", "taxa": []}
{"type": "biolink:Cell", "ic": 65.01429802748376, "identifiers": [{"i": "CL:0000164", "l": "enteroendocrine cell", "d": ["An endocrine cell that is located in the epithelium of the gastrointestinal tract or in the pancreas."], "t": []}, {"i": "UMLS:C0524979", "l": "Enteroendocrine Cell", "d": [], "t": []}, {"i": "NCIT:C45968", "l": "Enteroendocrine Cell", "d": ["A hormone-secreting cell present in the epithelium of the intestine."], "t": []}, {"i": "MESH:D019858", "l": "Enteroendocrine Cells", "d": [], "t": []}], "preferred_name": "enteroendocrine cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5157322", "l": "CD158 cells | XXX | Cell markers", "d": [], "t": []}], "preferred_name": "CD158 cells | XXX | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0229543", "l": "Pituitary hypertrophic amphophil cell", "d": [], "t": []}, {"i": "SNOMEDCT:63926000", "l": "", "d": [], "t": []}], "preferred_name": "Pituitary hypertrophic amphophil cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:1000721", "l": "kidney papillary duct principal cell", "d": ["Any renal principal cell that is part of some papillary duct."], "t": []}], "preferred_name": "kidney papillary duct principal cell", "taxa": []}
{"type": "biolink:Cell", "ic": 74.64805296934512, "identifiers": [{"i": "UMLS:C1512106", "l": "Dysplastic Megakaryocyte", "d": [], "t": []}, {"i": "NCIT:C37046", "l": "Dysplastic Megakaryocyte", "d": [], "t": []}], "preferred_name": "Dysplastic Megakaryocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 77.82747199602274, "identifiers": [{"i": "CL:0019019", "l": "tracheobronchial smooth muscle cell", "d": ["A smooth muscle cell that is part of the tracheobronchial tree."], "t": []}], "preferred_name": "tracheobronchial smooth muscle cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1513017", "l": "Maturation-Stage Ameloblast", "d": [], "t": []}, {"i": "NCIT:C33057", "l": "Maturation-Stage Ameloblast", "d": ["A short columnar epithelial cell that has deposited enamel and has lost organic material and water. It deposits calcium and phosphorus into the enamel matrix. The maturation-stage ameloblast produces and secretes small amounts of proteins."], "t": []}], "preferred_name": "Maturation-Stage Ameloblast", "taxa": []}
{"type": "biolink:Cell", "ic": 87.18682603146104, "identifiers": [{"i": "CL:0002355", "l": "primitive red blood cell", "d": ["A large nucleated basophilic erythrocyte found in mammalian embryos. This cell type arises from the blood islands of yolk sacs and expresses different types of hemoglobins (beta-H1, gamma-1 and zeta) than adult erythrocytes. Considered a type of erythroblast as this cell type can enucleate in circulation."], "t": []}], "preferred_name": "primitive red blood cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4072021", "l": "corticotropin-releasing neuron", "d": ["A specialised type of interneuron defined by the secretion of corticotropin-releasing hormone (CRH), a key peptide in activating the hypothalamic–pituitary–adrenal (HPA) axis during stress. It is primarily located in the paraventricular nucleus (PVN) of the hypothalamus, with additional presence in the hippocampus, piriform area, central amygdalar nucleus, Barrington’s nucleus, and inferior olivary complex (Peng et al., 2017)."], "t": []}], "preferred_name": "corticotropin-releasing neuron", "taxa": []}
{"type": "biolink:Cell", "ic": 79.64650900338474, "identifiers": [{"i": "CL:0001024", "l": "CD34-positive, CD38-negative hematopoietic stem cell", "d": ["CD133-positive hematopoietic stem cell is a hematopoietic stem cell that is CD34-positive, CD90-positive, and CD133-positive."], "t": []}], "preferred_name": "CD34-positive, CD38-negative hematopoietic stem cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0020038", "l": "middle zone articular chondrocyte", "d": ["An articular chondrocyte located in the middle (transitional) zone of articular cartilage, characterized by round morphology and relatively random spatial organization, and residing in a matrix enriched in proteoglycans and thicker collagen fibrils oriented obliquely to the articular surface. This cell contributes to the largest volume fraction of articular cartilage and functions primarily in distributing and absorbing compressive loads between the superficial and deep zones."], "t": []}], "preferred_name": "middle zone articular chondrocyte", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0545588", "l": "Blood plasmacytic cell", "d": [], "t": []}], "preferred_name": "Blood plasmacytic cell", "taxa": []}
{"type": "biolink:Cell", "ic": 86.30756602822301, "identifiers": [{"i": "CL:0000908", "l": "CD8-positive, alpha-beta cytokine secreting effector T cell", "d": ["A CD8-positive, alpha-beta T cell with the phenotype CD69-positive, CD62L-negative, CD127-negative, and CD25-positive, that secretes cytokines."], "t": []}], "preferred_name": "CD8-positive, alpha-beta cytokine secreting effector T cell", "taxa": []}
{"type": "biolink:Cell", "ic": 57.588499866114354, "identifiers": [{"i": "CL:0000165", "l": "neuroendocrine cell", "d": ["A neuron that is capable of some hormone secretion in response to neuronal signals."], "t": []}, {"i": "UMLS:C1518275", "l": "Neuroendocrine Cells", "d": [], "t": []}, {"i": "NCIT:C12485", "l": "Neuroendocrine Cell", "d": ["An endocrine cell that produces and releases hormones and regulatory proteins such as neurotransmitters and neuropeptide hormones. This type of cell enables autocrine communication with paracrine and endocrine cells throughout the body."], "t": []}, {"i": "MESH:D055099", "l": "Neuroendocrine Cells", "d": [], "t": []}], "preferred_name": "neuroendocrine cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5856685", "l": "Allogeneic Anti-CD6 CAR T-regulatory Cells", "d": [], "t": []}, {"i": "NCIT:C201288", "l": "Allogeneic Anti-CD6 CAR T-regulatory Cells", "d": ["A preparation of allogeneic T-regulatory cells (Tregs) that have been genetically modified to express a chimeric antigen receptor (CAR) targeting the T-cell differentiation antigen CD6, with potential immunmodulating activity. Upon administration, the allogeneic anti-CD6 CAR Tregs may promote immunologic homeostasis and prevent autoimmunity. This may induce tolerance to allogeneic hematopoietic stem cell transplants, prevent graft-versus-host disease (GvHD), and suppress autoimmune pathology. The allogeneic anti-CD6 CAR Tregs also targets and binds to CD6, which may prevent CD6-mediated activation pathways, downregulate the activation and differentiation of T-cells, and reduce the synthesis of pro-inflammatory cytokines. CD6, a co-stimulatory molecule predominantly expressed on lymphocytes, is involved in the adhesion and maturation of T-cells."], "t": []}], "preferred_name": "Allogeneic Anti-CD6 CAR T-regulatory Cells", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1517356", "l": "Geron H13 stem cell line", "d": [], "t": []}, {"i": "NCIT:C20259", "l": "GE13", "d": ["Provider: Geron Corporation, Menlo Park, CA. No information from provider. This cell line meets the criteria for the use of human embryonic stem cells by federally funded researchers."], "t": []}], "preferred_name": "Geron H13 stem cell line", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4052065", "l": "serous acinar cell of salivary gland", "d": ["An acinar cell of the salivary gland, characterized by a pyramidal or triangular shape with a spherical nucleus and abundant eosinophilic zymogen granules. This cell secretes watery, enzyme‐rich fluid containing α-amylase, proline-rich proteins, and secretory immunoglobulins for starch digestion and antimicrobial defence. In humans and mice, serous acinar cell predominates in the parotid gland and to a lesser extent in the submandibular gland, where it exists alongside mucous acinar cells (Maruyama et al., 2019)."], "t": []}], "preferred_name": "serous acinar cell of salivary gland", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5173495", "l": "Mononuclear cells | Cerebral spinal fluid | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Mononuclear cells | Cerebral spinal fluid | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": 55.25989730443806, "identifiers": [{"i": "UMLS:C0039195", "l": "Cytotoxic T-Lymphocytes", "d": [], "t": []}, {"i": "NCIT:C12543", "l": "Cytotoxic T-Lymphocyte", "d": ["Immunized T-lymphocytes which can directly destroy appropriate target cells. These cytotoxic lymphocytes may be generated in vitro in mixed lymphocyte cultures (MLC), in vivo during a graft-versus-host (GVH) reaction, or after immunization with an allograft, tumor cell or virally transformed or chemically modified target cell. These cells are distinct from natural killer cells and from killer cells mediating antibody-dependent cell cytotoxicity."], "t": []}, {"i": "MESH:D013602", "l": "T-Lymphocytes, Cytotoxic", "d": [], "t": []}, {"i": "SNOMEDCT:420638008", "l": "", "d": [], "t": []}], "preferred_name": "Cytotoxic T-Lymphocytes", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0010000", "l": "keratinized cell of hair follicle", "d": ["A differentiating matrix keratinocyte that has initiated terminal differentiation and keratin synthesis. This cell undergoes a characteristic change while migrating upward from the hair follicle bulb, representing a committed progenitor cell destined to form the hair medulla, cortex and hair root sheath."], "t": []}], "preferred_name": "keratinized cell of hair follicle", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5417933", "l": "Allogeneic Anti-CD19 CAR T-cells ALLO-501A", "d": [], "t": []}], "preferred_name": "Allogeneic Anti-CD19 CAR T-cells ALLO-501A", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "CL:0002556", "l": "fibroblast of periodontium", "d": ["A fibroblast of the periodontium."], "t": []}], "preferred_name": "fibroblast of periodontium", "taxa": []}
{"type": "biolink:Cell", "ic": 71.57077045273823, "identifiers": [{"i": "CL:1000746", "l": "glomerular cell", "d": ["Any kidney corpuscule cell that is part of some renal glomerulus."], "t": []}], "preferred_name": "glomerular cell", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "CL:2000039", "l": "posterior lateral line neuromast supporting cell", "d": ["Any neuromast support cell that is part of a posterior lateral line."], "t": []}], "preferred_name": "posterior lateral line neuromast supporting cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0600531", "l": "U937 Cells", "d": [], "t": []}, {"i": "MESH:D020298", "l": "U937 Cells", "d": [], "t": []}], "preferred_name": "U937 Cells", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5163714", "l": "Erythrocytes | Dialysis fluid | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Erythrocytes | Dialysis fluid | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0545063", "l": "P.B. osteoclast", "d": [], "t": []}], "preferred_name": "P.B. osteoclast", "taxa": []}
{"type": "biolink:Cell", "ic": 80.61184433509295, "identifiers": [{"i": "CL:0000811", "l": "CD8-positive, alpha-beta thymocyte", "d": ["An immature alpha-beta T cell that is located in the thymus and is CD8-positive and CD4-negative."], "t": []}], "preferred_name": "CD8-positive, alpha-beta thymocyte", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1267969", "l": "Lymphocyte positive for CD77 antigen", "d": [], "t": []}, {"i": "SNOMEDCT:117409002", "l": "", "d": [], "t": []}], "preferred_name": "Lymphocyte positive for CD77 antigen", "taxa": []}
{"type": "biolink:Cell", "ic": 82.62268137420203, "identifiers": [{"i": "CL:1001571", "l": "hippocampal pyramidal neuron", "d": ["A pyramidal neuron with a soma found in the hippocampus."], "t": []}], "preferred_name": "hippocampal pyramidal neuron", "taxa": []}
{"type": "biolink:Cell", "ic": 90.871710685482, "identifiers": [{"i": "CL:0000614", "l": "basophilic myelocyte", "d": ["A basophil precursor in the granulocytic series, being a cell intermediate in development between a promyelocyte and a metamyelocyte; in this stage, production of primary granules is complete and basophil-specific granules has started. No nucleolus is present. Markers are being integrin alpha-M-positive, fucosyltransferase FUT4-positive, CD33-positive, CD24-positive, aminopeptidase N-positive."], "t": []}], "preferred_name": "basophilic myelocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 90.871710685482, "identifiers": [{"i": "CL:0002385", "l": "blastoconidium", "d": ["An oblong or round asexual spore formed from conidial chains."], "t": []}], "preferred_name": "blastoconidium", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1517642", "l": "KA42", "d": [], "t": []}, {"i": "NCIT:C20272", "l": "KA42", "d": ["Provider: Karolinska Institute, Stockholm, Sweden. No information from provider. This cell line meets the criteria for the use of human embryonic stem cells by federally funded researchers."], "t": []}], "preferred_name": "KA42", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1979696", "l": "Ependymal+Choroid plexus cells", "d": [], "t": []}], "preferred_name": "Ependymal+Choroid plexus cells", "taxa": []}
{"type": "biolink:Cell", "ic": 92.76600187037766, "identifiers": [{"i": "CL:1001588", "l": "colon glandular cell", "d": ["Glandular cell of colon epithelium. Example: Goblet cells; enterocytes or absorptive cells; enteroendocrine and M cells."], "t": []}], "preferred_name": "colon glandular cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1267867", "l": "Lymphocyte positive for CD11B antigen", "d": [], "t": []}, {"i": "SNOMEDCT:117548004", "l": "", "d": [], "t": []}], "preferred_name": "Lymphocyte positive for CD11B antigen", "taxa": []}
{"type": "biolink:Cell", "ic": 85.53200374075534, "identifiers": [{"i": "CL:0009006", "l": "enteroendocrine cell of small intestine", "d": ["An enteroendocrine cell that is located in the small intestine."], "t": []}], "preferred_name": "enteroendocrine cell of small intestine", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5700380", "l": "LN-144", "d": [], "t": []}], "preferred_name": "LN-144", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C4725081", "l": "Allogeneic interleukin-17-producing CD8-positive T-cells", "d": [], "t": []}, {"i": "NCIT:C148499", "l": "Allogeneic interleukin-17-producing CD8-positive T-cells", "d": ["A preparation of allogeneic human cytotoxic T-lymphocytes that express the pro-inflammatory cytokine interleukin-17 (IL-17; IL17), with potential immunomodulating and anti-tumor activities. Upon ex vivo stimulation, the IL-17-producing CD8-positive T-cells (Tc17) convert to interferon-gamma (IFNg; IFN-g)-producing CD8-positive T-cells (Tc1). Tc1 cells exert enhanced anti-tumor cytotoxicity. Human Tc17 cells may contribute to a number of human inflammatory and malignant diseases."], "t": []}], "preferred_name": "Allogeneic interleukin-17-producing CD8-positive T-cells", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5219170", "l": "Leukocytes|NCnc|Urine", "d": [], "t": []}], "preferred_name": "Leukocytes|NCnc|Urine", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C2919941", "l": "Colony-forming unit of monocytic lineage", "d": [], "t": []}, {"i": "SNOMEDCT:445094003", "l": "", "d": [], "t": []}], "preferred_name": "Colony-forming unit of monocytic lineage", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1519121", "l": "SA02", "d": [], "t": []}, {"i": "NCIT:C20265", "l": "SA02", "d": ["Provider: Goteborg University, Goteborg, Sweden. No information from provider. This cell line meets the criteria for the use of human embryonic stem cells by federally funded researchers."], "t": []}], "preferred_name": "SA02", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1514436", "l": "Primitive Mesenchymal Plump Cell", "d": [], "t": []}, {"i": "NCIT:C37090", "l": "Primitive Mesenchymal Plump Cell", "d": [], "t": []}], "preferred_name": "Primitive Mesenchymal Plump Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 92.76600187037766, "identifiers": [{"i": "CL:1000550", "l": "kidney papillary duct principal epithelial cell", "d": ["Any kidney cell that is part of some papillary duct."], "t": []}], "preferred_name": "kidney papillary duct principal epithelial cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C3496151", "l": "A6 cell group", "d": [], "t": []}], "preferred_name": "A6 cell group", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5853442", "l": "fibrinogen-depleted human platelet lysate", "d": [], "t": []}], "preferred_name": "fibrinogen-depleted human platelet lysate", "taxa": []}
{"type": "biolink:Cell", "ic": 80.96785908349635, "identifiers": [{"i": "UMLS:C1512566", "l": "Hypolobated Neutrophil", "d": [], "t": []}, {"i": "NCIT:C37172", "l": "Hypolobated Neutrophil", "d": [], "t": []}], "preferred_name": "Hypolobated Neutrophil", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4696702", "l": "CD19+CD21- cell", "d": [], "t": []}, {"i": "SNOMEDCT:1373169000", "l": "", "d": [], "t": []}], "preferred_name": "CD19+CD21- cell", "taxa": []}
{"type": "biolink:Cell", "ic": 90.871710685482, "identifiers": [{"i": "UMLS:C1512637", "l": "Immature Peripheral Alpha/Beta Cell of Cytotoxic Type", "d": [], "t": []}, {"i": "NCIT:C38327", "l": "Immature Peripheral Alpha/Beta Cell of Cytotoxic Type", "d": ["A cell derived from stem cells in the bone marrow. It is a maturing T lymphocyte that expresses an alpha-beta antigen specific surface receptor (TCR) and the CD8 surface marker. These cells mature in the thymus."], "t": []}], "preferred_name": "Immature Peripheral Alpha/Beta Cell of Cytotoxic Type", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0882814", "l": "Cell positive for CD2 antigen", "d": [], "t": []}, {"i": "SNOMEDCT:732268004", "l": "", "d": [], "t": []}], "preferred_name": "Cell positive for CD2 antigen", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C6070750", "l": "Ideal erythrocyte | Patient | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Ideal erythrocyte | Patient | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "CL:0000876", "l": "splenic white pulp macrophage", "d": ["A splenic macrophage found in the white pulp of the spleen. Markers include F4/80-negative, CD68-positive, and macrosialin-positive."], "t": []}], "preferred_name": "splenic white pulp macrophage", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4042005", "l": "stromal choroid plexus macrophage", "d": ["A choroid plexus macrophage that is part of a choroid plexus stroma."], "t": []}], "preferred_name": "stromal choroid plexus macrophage", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1522238", "l": "Mouse Thyroid Gland Follicular Cell", "d": [], "t": []}, {"i": "NCIT:C22652", "l": "Mouse Thyroid Gland Follicular Cell", "d": [], "t": []}], "preferred_name": "Mouse Thyroid Gland Follicular Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1517359", "l": "GE92", "d": [], "t": []}, {"i": "NCIT:C20262", "l": "GE92", "d": ["Provider: Geron Corporation, Menlo Park, CA. No information from provider. This cell line meets the criteria for the use of human embryonic stem cells by federally funded researchers."], "t": []}], "preferred_name": "GE92", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0882842", "l": "CD3-CD19+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:1373178006", "l": "", "d": [], "t": []}], "preferred_name": "CD3-CD19+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5446938", "l": "Autologous Anti-NY-ESO-1 TCR/dnTGF-BRII-expressing T-cells GSK3845097", "d": [], "t": []}, {"i": "NCIT:C176041", "l": "Autologous Anti-NY-ESO-1 TCR/dnTGF-BRII-expressing T-cells GSK3845097", "d": ["A preparation of human autologous T-lymphocytes that are genetically modified to express a T-cell receptor (TCR) specific for the human cancer-testis antigen NY-ESO-1 and a dominant negative (dn) form of transforming growth factor-beta (TGF-beta; TGFb) receptor (dnTGF-BRII), with potential immunostimulating and antineoplastic activities. Upon leukapheresis, isolation, transduction, expansion ex vivo, and reintroduction into the patient, the autologous anti-NY-ESO-1 TCR/dnTGF-BRII-expressing T-cells GSK3845097 recognize and bind to NY-ESO-1-overexpressing tumor cells. This may result in a specific cytotoxic T-lymphocyte (CTL)-mediated killing of NY-ESO-1-positive tumor cells. NY-ESO-1, a tumor-associated antigen (TAA), is found in normal testis and on the surface of various tumor cell types. The inclusion of dnTGF-BRII blocks the signaling of the immunosuppressive cytokine TGFb in the tumor microenvironment (TME) and makes the GSK3845097 T-cells resistant to TGFb. TGFb negatively regulates T-cell proliferation and activation and plays a key role in tumor immune suppression."], "t": []}], "preferred_name": "Autologous Anti-NY-ESO-1 TCR/dnTGF-BRII-expressing T-cells GSK3845097", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5666935", "l": "Dimerizing Agent Regulated Immunoreceptor Complex-expressing CD33-specific Autologous CAR T Cells SC-DARIC33", "d": [], "t": []}, {"i": "NCIT:C184954", "l": "Dimerizing Agent Regulated Immunoreceptor Complex-expressing CD33-specific Autologous CAR T Cells SC-DARIC33", "d": ["A preparation of equal amounts of autologous CD4-positive and CD8-positive T-lymphocytes transduced with a lentiviral vector expressing a chimeric antigen receptor (CAR) specific for the tumor-associated antigen (TAA) CD33 and genetically modified to express a Dimerizing Agent Regulated Immunoreceptor Complex (DARIC), with potential immunomodulating and antineoplastic activities. Upon transfusion of the DARIC-expressing CD33-specific autologous CAR T-cells SC-DARIC33 and followed by intermittent low dose rapamycin administration, rapamycin binds to DARIC and activates the T-cells when binding to CD33-expressing tumor cells, thereby inducing selective toxicity in CD33-expressing tumor cells. CD33 is expressed on normal non-pluripotent hematopoietic stem cells and on myeloid leukemia cells. The ability of rapamycin to control the activity of the DARIC cells may help control the toxicity of the CAR T-cells, prevent T-cell exhaustion and may help them last longer in vivo. Using the DARIC platform, the antigen recognition and signaling functions of a CAR are separated into two distinct polypeptides and engineered to contain the two interacting and dimerization domains, FK506-binding protein (FKPB12) and FKBP12-rapamycin-binding (FRB) protein. In the absence of the dimerizing drug rapamycin, the CAR T-cells lack signaling activity upon antigen recognition and binding. The administration of the dimerizing agent enables the two DARIC subunits to interact and thereby allows for the CAR T-cells to fully function and activate their signaling abilities upon antigen recognition."], "t": []}], "preferred_name": "Dimerizing Agent Regulated Immunoreceptor Complex-expressing CD33-specific Autologous CAR T Cells SC-DARIC33", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0599409", "l": "sensory transducer cell", "d": [], "t": []}], "preferred_name": "sensory transducer cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5421182", "l": "Mocemestrocel", "d": [], "t": []}, {"i": "NCIT:C175146", "l": "Mocemestrocel", "d": [], "t": []}], "preferred_name": "Mocemestrocel", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1510958", "l": "Atypical Lobular Epithelial Cell", "d": [], "t": []}, {"i": "NCIT:C36885", "l": "Atypical Lobular Epithelial Cell", "d": [], "t": []}], "preferred_name": "Atypical Lobular Epithelial Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C4744687", "l": "Autologous Anti-CD22 CAR-4-1BB-TCRz-transduced T-lymphocytes CART22-65s", "d": [], "t": []}, {"i": "NCIT:C156251", "l": "Autologous Anti-CD22 CAR-4-1BB-TCRz-transduced T-lymphocytes CART22-65s", "d": ["Autologous human T-lymphocytes transduced with a recombinant lentiviral vector encoding a chimeric antigen receptor (CAR) consisting of an anti-CD22 human single chain variable fragment (scFv) and linked to the co-stimulatory domain 4-1BB (CD137) coupled to the zeta chain of the TCR/CD3 complex (CD3-zeta), with potential immunostimulating and antineoplastic activities. Upon reintroduction into the patient, the autologous anti-CD22 CAR-4-1BB-TCRz -transduced T-lymphocytes CART22-65s express anti-CD22-CAR on their cell surfaces and bind to the CD22 antigen on tumor cell surfaces, resulting in lysis of CD22-expressing tumor cells. CD22, a B-lineage-restricted, transmembrane phosphoglycoprotein, is expressed on malignant B-cells."], "t": []}], "preferred_name": "Autologous Anti-CD22 CAR-4-1BB-TCRz-transduced T-lymphocytes CART22-65s", "taxa": []}
{"type": "biolink:Cell", "ic": 73.49439205968403, "identifiers": [{"i": "UMLS:C1707913", "l": "Endometrioid Stromal Cell", "d": [], "t": []}, {"i": "NCIT:C53995", "l": "Endometrioid Stromal Cell", "d": [], "t": []}], "preferred_name": "Endometrioid Stromal Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 59.57089336698674, "identifiers": [{"i": "UMLS:C1510731", "l": "Abnormal Myeloid Cell", "d": [], "t": []}, {"i": "NCIT:C37042", "l": "Abnormal Myeloid Cell", "d": [], "t": []}], "preferred_name": "Abnormal Myeloid Cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C2950760", "l": "Interdigitating dendritic cell of mucosa-associated lymphoid tissue", "d": [], "t": []}], "preferred_name": "Interdigitating dendritic cell of mucosa-associated lymphoid tissue", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5163689", "l": "Erythrocyte inclusion bodies | Blood | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Erythrocyte inclusion bodies | Blood | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1517915", "l": "Mouse Ito Cell", "d": [], "t": []}, {"i": "NCIT:C22519", "l": "Mouse Ito Cell", "d": [], "t": []}], "preferred_name": "Mouse Ito Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 92.76600187037766, "identifiers": [{"i": "CL:0002060", "l": "melanophage", "d": ["A melanin-containing macrophage that obtains the pigment by phagocytosis of melanosomes."], "t": []}], "preferred_name": "melanophage", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C4733634", "l": "Autologous CCR4-CD30CAR-CD28-CD3zeta-expressing T-Lymphocytes", "d": [], "t": []}, {"i": "NCIT:C155293", "l": "Autologous CCR4-CD30CAR-CD28-CD3zeta-expressing T-Lymphocytes", "d": ["A preparation of autologous T-lymphocytes (ATL) that have been transduced with the retroviral vector SFG, a Moloney murine leukemia (Mo-MuLV) virus-based vector, encoding human C-C chemokine receptor 4 (CCR4), linked via an internal ribosome entry site (IRES), to a chimeric antigen receptor (CAR) composed of a single chain single-chain variable fragment (scFv) directed against the CD30 antigen (CAR.CD30) and linked, via the spacer human IgG1 immunoglobulin heavy constant region (hinge-CH2CH3 region), to the co-stimulatory domains of CD28 and the zeta chain of the TCR/CD3 complex (CD3-zeta) (CD28zeta), with potential immunostimulating and antineoplastic activities. Upon administration of the autologous CCR4-CD30CAR-CD28-CD3zeta-expressing T-lymphocytes, the expressed CCR4 on the T-cells allows for enhanced migration of the cells to chemokine-secreting tumor cells. The expressed CAR.CD30 moiety specifically recognizes and binds to CD30-expressing tumor cells, resulting in specific T-cell-mediated tumor cell lysis. CD30, a cell surface receptor and a member of the tumor necrosis factor (TNF) receptor superfamily, is transiently expressed on activated lymphocytes and is constitutively expressed in hematologic malignancies. CCR4, a G-coupled-protein receptor for C-C chemokines normally expressed on regulatory T-cells (Tregs) but not on cytotoxic T-lymphocytes (CTLs), is involved in chemokine-mediated cellular migration. The co-expression of CCR4 on these CTLs may enhance their anti-tumor activity compared to T-lymphocytes expressing the same CAR-CD30 receptor but without CCR4 expression."], "t": []}], "preferred_name": "Autologous CCR4-CD30CAR-CD28-CD3zeta-expressing T-Lymphocytes", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5173439", "l": "Monocytes | Vitreous fluid | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Monocytes | Vitreous fluid | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0000873", "l": "splenic metallophillic macrophage", "d": ["A splenic macrophage found in the areas surrounding the white pulp of the spleen, adjacent to the marginal sinus. Markers include F4/80-negative, Dectin2-low, sialoadhesin-positive."], "t": []}], "preferred_name": "splenic metallophillic macrophage", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5575123", "l": "Autologous Anti-BCMA CAR-T Cells JNJ-68284528", "d": [], "t": []}], "preferred_name": "Autologous Anti-BCMA CAR-T Cells JNJ-68284528", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1515153", "l": "TE72", "d": [], "t": []}, {"i": "NCIT:C20303", "l": "TE72", "d": ["Provider: Technion University, Haifa, Israel. No information from provider. This cell line meets the criteria for the use of human embryonic stem cells by federally funded researchers."], "t": []}], "preferred_name": "TE72", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0009106", "l": "medullary reticular cell", "d": ["A specialized fibroblast found in the medulla of lymph node."], "t": []}], "preferred_name": "medullary reticular cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5667075", "l": "PA3-17", "d": [], "t": []}, {"i": "NCIT:C186666", "l": "Autologous Anti-CD7 CAR T Cells PA3-17", "d": ["A preparation of autologous T-lymphocytes that have been genetically engineered to express a chimeric antigen receptor (CAR) directed against the tumor-associated antigen (TAA) CD7, with potential immunostimulating and antineoplastic activities. Upon intravenous administration, the autologous anti-CD7 CAR T-cells PA3-17 specifically recognize and bind to CD7-expressing tumor cells, resulting in specific T-cell-mediated tumor cell lysis. CD7 is a transmembrane glycoprotein expressed by T-cells and natural killer (NK) cells and their precursors. It is expressed in the majority of lymphoblastic T-cell leukemias and lymphomas and in a subset of peripheral T-cell lymphomas."], "t": []}], "preferred_name": "PA3-17", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5554927", "l": "Autologous Anti-HER2 T-cell Antigen Coupler-expressing T Cells TAC01-HER2", "d": [], "t": []}], "preferred_name": "Autologous Anti-HER2 T-cell Antigen Coupler-expressing T Cells TAC01-HER2", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0009094", "l": "endothelial cell of hepatic portal vein", "d": ["An endothelial cell that is part of a hepatic portal vein."], "t": []}], "preferred_name": "endothelial cell of hepatic portal vein", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5163542", "l": "Epithelial cells | Urine | Urinalysis", "d": [], "t": []}], "preferred_name": "Epithelial cells | Urine | Urinalysis", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0017009", "l": "Axl+ dendritic cell, human", "d": ["A human dendritic cell that expresses the AXL and SIGLEC6 genes."], "t": []}], "preferred_name": "Axl+ dendritic cell, human", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0004224", "l": "AB diffuse-2 amacrine cell", "d": ["A broadly stratifying amacrine cell that has a small dendritic field and post-synaptic terminals in S2 and S3. This cell type releases the neurotransmitter glycine."], "t": []}], "preferred_name": "AB diffuse-2 amacrine cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C2953656", "l": "Set of glioblasts", "d": [], "t": []}], "preferred_name": "Set of glioblasts", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C2950600", "l": "Type D cell of jejunum", "d": [], "t": []}], "preferred_name": "Type D cell of jejunum", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5555871", "l": "NK Cells KDS-1001", "d": [], "t": []}], "preferred_name": "NK Cells KDS-1001", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5555592", "l": "Personalized Neoantigen-specific T-lymphocytes NEO-PTC-01", "d": [], "t": []}, {"i": "NCIT:C179294", "l": "Personalized Neoantigen-specific T-lymphocytes NEO-PTC-01", "d": ["A preparation of autologous, personalized tumor neoantigen-specific T-lymphocytes, with potential immunostimulating and antineoplastic activities. The T-cells are derived from the patients' peripheral blood mononuclear cells (PBMCs) and are primed and activated against tumor-specific neoantigens that are expressed on the patient's tumor cells or in the tumor microenvironment (TME), and expanded ex vivo. Upon administration, the autologous neoantigen-specific T-lymphocytes NEO-PTC-01 recognize and bind to tumor cells expressing the targeted neoantigens, resulting in a cytotoxic T-lymphocyte (CTL)-mediated immune response against the patient's tumor cells."], "t": []}], "preferred_name": "Personalized Neoantigen-specific T-lymphocytes NEO-PTC-01", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1516469", "l": "Chicken Cells", "d": [], "t": []}, {"i": "NCIT:C18695", "l": "Chicken Cells", "d": ["Cells derived from the chicken used as a biological model for research."], "t": []}], "preferred_name": "Chicken Cells", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1515628", "l": "gp100-Pulsed Peripheral Blood Mononuclear Cell", "d": [], "t": []}, {"i": "NCIT:C2762", "l": "gp100-Pulsed Peripheral Blood Mononuclear Cell", "d": ["Peripheral blood lymphocytes (PBL) harvested from host blood and stimulated in vitro with tumor-specific gp 100 antigen. 'Pulsing' PBL with gp100, a tumor associated antigen (TAA) commonly expressed by melanoma cells, may increase melanoma-reactive cytotoxic lymphocytes (CTL) in the PBL cell population. Autologous gp100-pulsed PBL have been administered to melanoma patients in order to augment cytotoxic immune responses to melanoma.  (NCI04)"], "t": []}], "preferred_name": "gp100-Pulsed Peripheral Blood Mononuclear Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C4086901", "l": "Therapeutic gamma delta T-lymphocytes", "d": [], "t": []}, {"i": "NCIT:C124644", "l": "Therapeutic gamma delta T-lymphocytes", "d": ["A subset of therapeutic autologous T-lymphocytes that express a T-cell receptor (TCR) composed of one gamma chain and one delta chain, with potential immunomodulating and antineoplastic activities. Upon administration of the therapeutic gamma delta T-lymphocytes, these cells secrete interferon-gamma (IFN-g), and exert direct killing of tumor cells. In addition, these cells activate the immune system to exert a cytotoxic T-lymphocyte (CTL) response against tumor cells. Gamma delta T-lymphocytes play a key role in the activation of the immune system and do not require major histocompatibility complex (MHC)-mediated antigen presentation to exert their cytotoxic effect."], "t": []}], "preferred_name": "Therapeutic gamma delta T-lymphocytes", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C4744501", "l": "M1 Macrophage", "d": [], "t": []}, {"i": "NCIT:C156004", "l": "M1 Macrophage", "d": ["A macrophage that expresses CD80 and CD86 on the cell surface, produces high levels of interleukin (IL)-8 and IL-12 and converts arginine to nitric oxide. These cells promote inflammation."], "t": []}], "preferred_name": "M1 Macrophage", "taxa": []}
{"type": "biolink:Cell", "ic": 62.62045599569923, "identifiers": [{"i": "CL:0009004", "l": "retinal cell", "d": ["Any cell in the retina, the innermost layer or coating at the back of the eyeball, which is sensitive to light and in which the optic nerve terminates."], "t": []}], "preferred_name": "retinal cell", "taxa": []}
{"type": "biolink:Cell", "ic": 90.871710685482, "identifiers": [{"i": "CL:0002666", "l": "type II spiral ligament fibrocyte", "d": ["A spiral ligament fibrocyte that is located near the spiral prominence between the basilar crest and the stria and plays an important role in potassium recycling by actively pumping K+ from the extracellular space and facilitating transcellular K+ transport through gap junctions toward Type I fibrocytes. In mice, Type II fibrocytes express connexin 26 (Gjb2) and connexin 30 (Gjb6) as part of the mesenchymal gap junction system, as well as the Na‑K‑2Cl cotransporter NKCC1."], "t": []}], "preferred_name": "type II spiral ligament fibrocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:2000095", "l": "cord blood hematopoietic stem cell", "d": ["Any hematopoietic stem cell that is part of a umbilical cord blood."], "t": []}], "preferred_name": "cord blood hematopoietic stem cell", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "CL:4023092", "l": "inverted pyramidal neuron", "d": ["A pyramidal neuron which has an apical tree which is oriented towards the white matter."], "t": []}], "preferred_name": "inverted pyramidal neuron", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4033131", "l": "celiac ganglion SP neuron", "d": ["A sympathetic neuron that has the soma located in the celiac ganglion and expresses the marker substance P (SP)."], "t": []}], "preferred_name": "celiac ganglion SP neuron", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5556490", "l": "Autologous Anti-HER2 CAR-T Cells", "d": [], "t": []}, {"i": "NCIT:C180598", "l": "Autologous Anti-HER2 CAR-T Cells", "d": ["A preparation of autologous T-lymphocytes that have been genetically modified to express a chimeric antigen receptor (CAR) targeting the tumor-associated antigen (TAA) human epidermal growth factor receptor 2 (HER2; ErbB2; HER-2), with potential immunostimulating and antineoplastic activities. Upon administration, autologous anti-HER2 CAR-T cells target and bind to HER2-expressing tumor cells, thereby inducing selective toxicity in HER2-expressing tumor cells. HER2 is overexpressed in a variety of cancer cell types and is associated with increased tumor cell proliferation."], "t": []}], "preferred_name": "Autologous Anti-HER2 CAR-T Cells", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5221144", "l": "Mesothelial cells|NCnc|Pt|Periton fld", "d": [], "t": []}], "preferred_name": "Mesothelial cells|NCnc|Pt|Periton fld", "taxa": []}
{"type": "biolink:Cell", "ic": 80.96785908349635, "identifiers": [{"i": "CL:0002659", "l": "glandular epithelial cell of stomach", "d": ["A glandular epithelial cell that is part of the stomach."], "t": []}, {"i": "UMLS:C1517451", "l": "Glandular cell of stomach", "d": [], "t": []}, {"i": "NCIT:C32655", "l": "Gastric Glandular Cell", "d": ["A cell found in the gastric mucosa that produces and secretes digestive enzymes and acid."], "t": []}], "preferred_name": "glandular epithelial cell of stomach", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5761866", "l": "ET 1402L1-CART", "d": [], "t": []}], "preferred_name": "ET 1402L1-CART", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0009026", "l": "enterocyte of appendix", "d": ["An enterocyte that is a part of a vermiform appendix."], "t": []}], "preferred_name": "enterocyte of appendix", "taxa": []}
{"type": "biolink:Cell", "ic": 73.85694246010084, "identifiers": [{"i": "CL:0002573", "l": "Schwann cell", "d": ["A glial cell that myelinates or ensheathes axons in the peripheral nervous system."], "t": []}, {"i": "UMLS:C0036387", "l": "Schwann Cells", "d": [], "t": []}, {"i": "NCIT:C12620", "l": "Schwann Cell", "d": ["A supporting cell of the peripheral nervous system that aids the growth, development, function, maintenance and repair of peripheral nerves. Myelinating Schwann cells form the myelin sheath around large diameter axons while non-myelinating Schwann cells bundle together portions of several unmyelinated smaller diameter axons and may also play a role in the formation and maintenance of synaptic connections in the neuromuscular junction."], "t": []}, {"i": "MESH:D012583", "l": "Schwann Cells", "d": [], "t": []}, {"i": "SNOMEDCT:44591005", "l": "", "d": [], "t": []}], "preferred_name": "Schwann cell", "taxa": []}
{"type": "biolink:Cell", "ic": 53.37482963815787, "identifiers": [{"i": "CL:0000737", "l": "striated muscle cell", "d": ["Muscle cell which has as its direct parts myofilaments organized into sarcomeres."], "t": []}, {"i": "UMLS:C1514994", "l": "Striated muscle cell", "d": [], "t": []}, {"i": "NCIT:C33637", "l": "Striated Muscle Cell", "d": ["A cylindrical multinucleated cell containing contracting myofibrils, across which run transverse light and dark areas, enclosed in a delicate plasma membrane."], "t": []}], "preferred_name": "striated muscle cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0009082", "l": "committed double negative thymocyte (Homo sapiens)", "d": ["The human equivalent of a DN3 thymocyte; these thymocytes finish the process of beta selection."], "t": []}], "preferred_name": "committed double negative thymocyte (Homo sapiens)", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4518161", "l": "Population of all isolated head spermatozoa in portion of fluid", "d": [], "t": []}, {"i": "SNOMEDCT:725385000", "l": "", "d": [], "t": []}], "preferred_name": "Population of all isolated head spermatozoa in portion of fluid", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:1000716", "l": "kidney outer medulla collecting duct principal cell", "d": ["Principal cell that is part of some outer medullary collecting duct. It is known in some mammalian species that this cell may express the epithelial sodium channel (ENaC)."], "t": []}], "preferred_name": "kidney outer medulla collecting duct principal cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5706539", "l": "Membrane-bound IL-15-expressing Tumor-infiltrating Lymphocytes OBX-115", "d": [], "t": []}], "preferred_name": "Membrane-bound IL-15-expressing Tumor-infiltrating Lymphocytes OBX-115", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "CL:4030039", "l": "von Economo neuron", "d": ["An extratelencephalic-projecting glutamatergic cortical neuron that is morphologically-defined with a large, spindle-shaped cell body, thick bipolar dendrites with limited branching and a moderate density of spines, and often an axon initial segment that emanates from the side of the cell body. This cell type is associated with markers POU3F, BMP3 and ITGA4."], "t": []}], "preferred_name": "von Economo neuron", "taxa": []}
{"type": "biolink:Cell", "ic": 55.869810257409455, "identifiers": [{"i": "UMLS:C0027836", "l": "Neuroglia", "d": [], "t": []}, {"i": "NCIT:C12615", "l": "Glial Cell", "d": ["A non-neuronal cell of the nervous system. Glial cells have diverse roles, including in regulation of neuronal survival and differentiation, maintenance of ion and neurotransmitter concentrations in the neuronal environment, synapse formation, and support of synaptic interactions and electrical signal propagation."], "t": []}, {"i": "MESH:D009457", "l": "Neuroglia", "d": [], "t": []}, {"i": "SNOMEDCT:2156000", "l": "", "d": [], "t": []}, {"i": "SNOMEDCT:58861006", "l": "", "d": [], "t": []}], "preferred_name": "Neuroglia", "taxa": []}
{"type": "biolink:Cell", "ic": 64.63612700213389, "identifiers": [{"i": "CL:0000209", "l": "taste receptor cell", "d": ["A specialized cell involved in gustatory sensory perception."], "t": []}], "preferred_name": "taste receptor cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5707292", "l": "Autologous IL-7-expanded HER2-specific CD4+ T-cells", "d": [], "t": []}, {"i": "NCIT:C187686", "l": "Autologous IL-7-expanded HER2-specific CD4+ T-cells", "d": ["A preparation of autologous, interleukin-7 (IL-7)-expanded, human epidermal growth factor receptor 2 (EGFR2; HER2; ErbB2)-specific, cluster of differentiation 4 (CD4)-positive T-lymphocytes, with potential immunostimulating and antineoplastic activities. Autologous HER2-specific CD4+ T-cells are expanded ex vivo with IL-7. Upon reintroduction into the patient, the autologous IL-7-expanded HER2-specific CD4+ T-cells recognize and stimulate a T-cell-mediated immune response against HER2-expressing tumor cells. HER2, a receptor tyrosine kinase (RTK) mutated or overexpressed in many tumor cell types, plays a key role in tumor cell proliferation and tumor vascularization. IL-7 is a cytokine that promotes the proliferation and survival of T-cells."], "t": []}], "preferred_name": "Autologous IL-7-expanded HER2-specific CD4+ T-cells", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4033115", "l": "cervicothoracic ganglion TH/NPY neuron", "d": ["A sympathetic neuron that has the soma located in the cervicothoracic ganglion and expresses the marker tyrosine hydroxylase (TH) and neuropeptide Y (NPY)."], "t": []}], "preferred_name": "cervicothoracic ganglion TH/NPY neuron", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C4727550", "l": "Autologous ROR2-targeted CAR T-cells CCT301-59", "d": [], "t": []}, {"i": "NCIT:C154277", "l": "Autologous ROR2-targeted CAR T-cells CCT301-59", "d": ["A preparation of genetically modified autologous T-lymphocytes transduced with a lentiviral vector to express a chimeric antigen receptor (CAR) targeting the receptor tyrosine kinase-like orphan receptor 2 (ROR2), with potential immunomodulatory and antineoplastic activities. After isolation, transduction, and expansion in culture, CCT301-59 cells are reintroduced into the patient and are activated within the tumor microenvironment (TME) using proprietary Conditionally Active Biologic (CAB) technology. Upon activation, CAB antibodies bind to a proprietary T-cell signaling domain, promoting T-cell recognition and killing of ROR2-expressing tumor cells. ROR2 is involved in Wnt signal transduction and is involved in tumorigenesis and progression. ROR2 expression is upregulated in certain tumor types and high levels of ROR2 expression often correlates with poor prognosis."], "t": []}], "preferred_name": "Autologous ROR2-targeted CAR T-cells CCT301-59", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:1000378", "l": "type 1 vestibular sensory cell of stato-acoustic epithelium", "d": ["A type I vestibular sensory cell that is part of the stato-acoustic epithelium."], "t": []}, {"i": "UMLS:C2325183", "l": "Type 1 vestibular sensory cell of stato-acoustic epithelium", "d": [], "t": []}], "preferred_name": "type 1 vestibular sensory cell of stato-acoustic epithelium", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0229652", "l": "Basophilic megakaryocyte", "d": [], "t": []}, {"i": "SNOMEDCT:75790005", "l": "", "d": [], "t": []}], "preferred_name": "Basophilic megakaryocyte", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1440233", "l": "CD100+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:725325003", "l": "", "d": [], "t": []}], "preferred_name": "CD100+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1516696", "l": "Collecting Cell", "d": [], "t": []}, {"i": "NCIT:C32343", "l": "Collecting Cell", "d": ["A simple cuboidal epithelial cell lining the collecting duct of the kidney. Its function is dependent upon its location on the collecting duct."], "t": []}], "preferred_name": "Collecting Cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C2737142", "l": "Monocytes.CD59", "d": [], "t": []}], "preferred_name": "Monocytes.CD59", "taxa": []}
{"type": "biolink:Cell", "ic": 89.40238429118027, "identifiers": [{"i": "CL:4301586", "l": "unipolar brush cell (Mmus)", "d": ["A unipolar brush cell of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Sln (Mmus), Lmx1a (Mmus). Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Supertype:1156 DCO UBC Glut_1."], "t": []}], "preferred_name": "unipolar brush cell (Mmus)", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1267840", "l": "Lymphocyte negative for CD3 antigen and positive for CD19 antigen", "d": [], "t": []}, {"i": "SNOMEDCT:116734009", "l": "", "d": [], "t": []}], "preferred_name": "Lymphocyte negative for CD3 antigen and positive for CD19 antigen", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0002243", "l": "smooth muscle cell of sphincter of pupil", "d": ["A circular smooth muscle cell of the iris, innervated by the ciliary nerves (parasympathetic), and acting to contract the pupil. This muscle cell derives from neuroectoderm. This smooth muscle cell results from transformation of epithelial cells to smooth muscle cells."], "t": []}, {"i": "UMLS:C1182651", "l": "Smooth muscle fiber of sphincter of pupil", "d": [], "t": []}], "preferred_name": "smooth muscle cell of sphincter of pupil", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0546508", "l": "P.B. lymphoblast", "d": [], "t": []}], "preferred_name": "P.B. lymphoblast", "taxa": []}
{"type": "biolink:Cell", "ic": 89.40238429118027, "identifiers": [{"i": "CL:4301591", "l": "Astro-TE NN_1 astrocyte (Mmus)", "d": ["A astrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Myoc (Mmus), Camk2a (Mmus). Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Supertype:1161 Astro-TE NN_1."], "t": []}], "preferred_name": "Astro-TE NN_1 astrocyte (Mmus)", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1978414", "l": "Blast cell positive for CD22 antigen", "d": [], "t": []}, {"i": "SNOMEDCT:724266008", "l": "", "d": [], "t": []}], "preferred_name": "Blast cell positive for CD22 antigen", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4316924", "l": "Cell positive for CD8 antigen", "d": [], "t": []}, {"i": "SNOMEDCT:732271007", "l": "", "d": [], "t": []}], "preferred_name": "Cell positive for CD8 antigen", "taxa": []}
{"type": "biolink:Cell", "ic": 86.30756602822301, "identifiers": [{"i": "UMLS:C1328818", "l": "Podocytes", "d": [], "t": []}, {"i": "NCIT:C33334", "l": "Podocyte", "d": ["A modified epithelial cell of the capsular epithelium of the renal glomerulus. It has a small perikaryon and a number of primary and secondary foot-like radiating processes (pedicels) that interdigitate with those of other podocytes and embrace the basal lamina of glomerular capillaries."], "t": []}, {"i": "MESH:D050199", "l": "Podocytes", "d": [], "t": []}], "preferred_name": "Podocytes", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4033169", "l": "pelvic ganglion VAChT neuron", "d": ["A parasympathetic neuron that has the soma located in the pelvic ganglion and expresses the marker vesicular acetylcholine transporter (VAChT)."], "t": []}], "preferred_name": "pelvic ganglion VAChT neuron", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0301867", "l": "Forbidden clone", "d": [], "t": []}, {"i": "SNOMEDCT:24309006", "l": "", "d": [], "t": []}], "preferred_name": "Forbidden clone", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0009081", "l": "specified double negative thymocyte (Homo sapiens)", "d": ["The human equivalent of a DN2 thymocyte; typically contains two phases, in the latter of which these thymocytes begin the process of beta selection."], "t": []}], "preferred_name": "specified double negative thymocyte (Homo sapiens)", "taxa": []}
{"type": "biolink:Cell", "ic": 85.53200374075534, "identifiers": [{"i": "CL:0000697", "l": "R4 photoreceptor cell", "d": [], "t": []}], "preferred_name": "R4 photoreceptor cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1267979", "l": "Lymphocyte positive for CD91 antigen", "d": [], "t": []}, {"i": "SNOMEDCT:117419008", "l": "", "d": [], "t": []}], "preferred_name": "Lymphocyte positive for CD91 antigen", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5454450", "l": "Leukocytes | Lower respiratory specimen | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Leukocytes | Lower respiratory specimen | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4079000", "l": "cervical dorsal root ganglion CGRP neuron", "d": ["A peptidergic nociceptor whose soma is located in the cervical dorsal root ganglion, characterized by expression of calcitonin gene-related peptide (CGRP, encoded by CALCA). This small- to medium-diameter neuron belongs to the TrkA-positive peptidergic subpopulation and typically co-expresses substance P. It innervates peripheral tissues including skin and viscera, where it mediates neurogenic inflammation and nociceptive signalling through release of CGRP from peripheral terminals during tissue injury (Haberberger et al. 2019, PMID:31293388). In human DRG, CGRP-immunoreactive neurons represent a substantial proportion of nociceptors, comparable to the pattern observed in rodents (Rostock et al. 2018, PMID:29229553)."], "t": []}], "preferred_name": "cervical dorsal root ganglion CGRP neuron", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5157355", "l": "CD19+CD27+IgD-IgM+ cells | Blood | Cell markers", "d": [], "t": []}], "preferred_name": "CD19+CD27+IgD-IgM+ cells | Blood | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5834509", "l": "Human major histocompatibility complex (MHC) non-restricted T-cell line 104", "d": [], "t": []}], "preferred_name": "Human major histocompatibility complex (MHC) non-restricted T-cell line 104", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:1001216", "l": "interlobulary artery endothelial cell", "d": ["Any endothelial cell that is part of some interlobular artery."], "t": []}], "preferred_name": "interlobulary artery endothelial cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4322821", "l": "CD13+ T lymphocyte", "d": [], "t": []}], "preferred_name": "CD13+ T lymphocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 67.8984399852903, "identifiers": [{"i": "CL:0000740", "l": "retinal ganglion cell", "d": ["The set of neurons that receives neural inputs via bipolar, horizontal and amacrine cells. The axons of these cells make up the optic nerve."], "t": []}, {"i": "UMLS:C0035316", "l": "Retinal Ganglion Cells", "d": [], "t": []}, {"i": "NCIT:C12642", "l": "Retinal Ganglion Cell", "d": ["An output neuron in the retina that receives visual signals from photoreceptors via interneurons, and transmits the information to the thalamus, hypothalamus, and superior colliculus of the brain through the optic nerve."], "t": []}, {"i": "MESH:D012165", "l": "Retinal Ganglion Cells", "d": [], "t": []}], "preferred_name": "retinal ganglion cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5171676", "l": "Lymphocytes Plasmacytoid | Blood | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Lymphocytes Plasmacytoid | Blood | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4697027", "l": "CD27-CD45RO+CD62L-CCR7- cell", "d": [], "t": []}, {"i": "SNOMEDCT:1373239003", "l": "", "d": [], "t": []}], "preferred_name": "CD27-CD45RO+CD62L-CCR7- cell", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "CL:1001580", "l": "hippocampal glial cell", "d": ["A glial cell that is part of the hippocampus."], "t": []}], "preferred_name": "hippocampal glial cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0000933", "l": "type II NK T cell secreting interleukin-4", "d": ["A type II NK T cell that has been recently activated, secretes interleukin-4, and has the phenotype CD69-positive and downregulated NK markers."], "t": []}], "preferred_name": "type II NK T cell secreting interleukin-4", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4324222", "l": "CD16+CD57+NK lymphocyte", "d": [], "t": []}], "preferred_name": "CD16+CD57+NK lymphocyte", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0333723", "l": "Folded cell", "d": [], "t": []}, {"i": "SNOMEDCT:39922000", "l": "", "d": [], "t": []}], "preferred_name": "Folded cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4033126", "l": "sacral ganglion TH neuron", "d": ["A sympathetic neuron that has the soma located in the sacral ganglion and expresses the marker tyrosine hydroxylase (TH)."], "t": []}], "preferred_name": "sacral ganglion TH neuron", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4033144", "l": "pterygopalatine ganglion VIP/PHI neuron", "d": ["A parasympathetic neuron that has the soma located in the pterygopalatine ganglion and expresses the marker vasoactive intestinal peptide (VIP) and peptide histidine isoleucine (PHI)."], "t": []}], "preferred_name": "pterygopalatine ganglion VIP/PHI neuron", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5163771", "l": "Erythroid cells | Blood or Marrow | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Erythroid cells | Blood or Marrow | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": 92.76600187037766, "identifiers": [{"i": "CL:1001138", "l": "interlobular artery cell", "d": ["Any kidney cortex artery cell that is part of some interlobular artery."], "t": []}], "preferred_name": "interlobular artery cell", "taxa": []}
{"type": "biolink:Cell", "ic": 72.11981073685999, "identifiers": [{"i": "CL:4023011", "l": "lamp5 GABAergic interneuron", "d": ["A transcriptomically distinct GABAergic neuron located in the cerebral cortex that expresses Lamp5.", "A transcriptomically distinct GABAergic neuron located in the cerebral cortex that expresses Lamp5. The standard transcriptomic reference data for this cell type can be found on the CellxGene census under the collection: 'Transcriptomic cytoarchitecture reveals principles of human neocortex organization', dataset: 'Supercluster: CGE-derived interneurons', Author Categories: 'CrossArea_subclass', clusters Lamp5."], "t": []}], "preferred_name": "lamp5 GABAergic interneuron", "taxa": []}
{"type": "biolink:Cell", "ic": 75.2337427109536, "identifiers": [{"i": "UMLS:C1514170", "l": "Pleomorphic Cell", "d": [], "t": []}, {"i": "NCIT:C37111", "l": "Pleomorphic Cell", "d": [], "t": []}], "preferred_name": "Pleomorphic Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 85.53200374075534, "identifiers": [{"i": "CL:0002169", "l": "basal cell of olfactory epithelium", "d": ["An epithelial cell located on the basal lamina of the olfactory epithelium."], "t": []}, {"i": "UMLS:C1179114", "l": "Basal cell of olfactory epithelium", "d": [], "t": []}, {"i": "NCIT:C13153", "l": "Olfactory Basal Cell", "d": ["A cell found in the pseudostratified epithelium lining the olfactory region of the nasal cavity. It gives rise to olfactory receptor cells and sustentacular cells."], "t": []}], "preferred_name": "basal cell of olfactory epithelium", "taxa": []}
{"type": "biolink:Cell", "ic": 46.88876190961718, "identifiers": [{"i": "CL:0000738", "l": "leukocyte", "d": ["An achromatic cell of the myeloid or lymphoid lineages capable of ameboid movement, found in blood or other tissue."], "t": []}, {"i": "UMLS:C0023516", "l": "Leukocytes", "d": [], "t": []}, {"i": "NCIT:C12529", "l": "Leukocyte", "d": ["Blood cells that are devoid of hemoglobin, capable of ameboid motion and phagocytosis, and act as the principal components of the immune system."], "t": []}, {"i": "MESH:D007962", "l": "Leukocytes", "d": [], "t": []}, {"i": "SNOMEDCT:52501007", "l": "", "d": [], "t": []}], "preferred_name": "leukocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 81.34422831136257, "identifiers": [{"i": "CL:0000553", "l": "megakaryocyte progenitor cell", "d": ["The earliest cytologically identifiable precursor in the thrombocytic series. This cell is capable of endomitosis and lacks expression of hematopoieitic lineage markers (lin-negative)."], "t": []}], "preferred_name": "megakaryocyte progenitor cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5216308", "l": "Platelets|NCnc|Pt|BldCo", "d": [], "t": []}], "preferred_name": "Platelets|NCnc|Pt|BldCo", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C2350247", "l": "Monocyte-Macrophage Progenitor Cells", "d": [], "t": []}], "preferred_name": "Monocyte-Macrophage Progenitor Cells", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0020056", "l": "calretinin-negative intrinsic primary afferent neuron of myenteric plexus", "d": ["An intrinsic primary afferent neuron of the myenteric plexus that lacks calretinin expression. This neuron shares the Dogiel type II morphology and AH-type electrophysiology of all myenteric IPANs, and is immunopositive for choline acetyltransferase (ChAT) and immunonegative for neuronal nitric oxide synthase (NOS1)."], "t": []}], "preferred_name": "calretinin-negative intrinsic primary afferent neuron of myenteric plexus", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C0333837", "l": "Gaucher cell", "d": [], "t": []}, {"i": "NCIT:C36731", "l": "Gaucher Cell", "d": [], "t": []}, {"i": "SNOMEDCT:16216007", "l": "", "d": [], "t": []}], "preferred_name": "Gaucher cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0008022", "l": "endocardial cushion cell", "d": ["A mesenchymal cell of the endocardial cushion.   These cells develop via an epithelial to mesenchymal transition when endocardial cells break cell-to-cell contacts and migrate into the cardiac jelly. Cells from this population form the heart septa and valves."], "t": []}], "preferred_name": "endocardial cushion cell", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "CL:4030049", "l": "striosomal D2 medium spiny neuron", "d": ["A DRD2-expressing medium spiny neuron that is part of a striosome of dorsal striatum."], "t": []}], "preferred_name": "striosomal D2 medium spiny neuron", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "CL:4030023", "l": "respiratory tract hillock cell", "d": ["A hillock cell that is located in respiratory epithelium. In some mammalian species, this cell type has been noted to express KRT13 and KRT4 and is postulated to play a role in squamous barrier function and immunomodulation."], "t": []}], "preferred_name": "respiratory tract hillock cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5707274", "l": "Autologous Anti-B7-H3 CAR T Cells CAR.B7-H3T", "d": [], "t": []}, {"i": "NCIT:C187657", "l": "Autologous Anti-B7-H3 CAR T Cells CAR.B7-H3T", "d": ["A preparation of autologous T-lymphocytes that have been genetically engineered to express a chimeric antigen receptor (CAR) targeting the immunoregulatory protein B7-homologue 3 (B7-H3, CD276) and containing, as of yet undisclosed co-stimulatory signaling domains, with potential immunostimulating and antineoplastic activities. Upon infusion back into the patient, autologous anti-B7-H3 CAR T cells CAR.B7-H3T target and bind to B7-H3-expressing tumor cells, thereby inducing selective toxicity in B7-H3-expressing tumor cells. B7-H3, a type I transmembrane protein and a member of the B7 co-stimulatory protein superfamily, is overexpressed on certain tumor cell types and on various immune cells. It is a negative regulator of the T-cell activation and its overexpression plays a key role in tumor cell invasion and metastasis."], "t": []}], "preferred_name": "Autologous Anti-B7-H3 CAR T Cells CAR.B7-H3T", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0682526", "l": "lymphoblastoid cell line", "d": [], "t": []}], "preferred_name": "lymphoblastoid cell line", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1523992", "l": "Mouse Histiocyte", "d": [], "t": []}, {"i": "NCIT:C22588", "l": "Mouse Histiocyte", "d": [], "t": []}], "preferred_name": "Mouse Histiocyte", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C3899973", "l": "idecabtagene vicleucel", "d": [], "t": []}, {"i": "MESH:C000715380", "l": "idecabtagene vicleucel", "d": [], "t": []}, {"i": "SNOMEDCT:1156047000", "l": "", "d": [], "t": []}, {"i": "SNOMEDCT:1156050002", "l": "", "d": [], "t": []}], "preferred_name": "idecabtagene vicleucel", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5966207", "l": "CTL 019", "d": [], "t": []}], "preferred_name": "CTL 019", "taxa": []}
{"type": "biolink:Cell", "ic": 90.871710685482, "identifiers": [{"i": "UMLS:C0333851", "l": "Sezary cell", "d": [], "t": []}, {"i": "NCIT:C36722", "l": "Sezary Cell", "d": ["A large, neoplastic T-lymphocyte with an irregularly shaped nuclei and scant cytoplasm that is associated with Sezary Syndrome."], "t": []}, {"i": "SNOMEDCT:45614000", "l": "", "d": [], "t": []}], "preferred_name": "Sezary cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C3869774", "l": "Siderocytes.HPF", "d": [], "t": []}], "preferred_name": "Siderocytes.HPF", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5157476", "l": "CD30 cells | Blood | Cell markers", "d": [], "t": []}], "preferred_name": "CD30 cells | Blood | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5761403", "l": "Cell positive for estrogen receptor", "d": [], "t": []}, {"i": "SNOMEDCT:1234915002", "l": "", "d": [], "t": []}], "preferred_name": "Cell positive for estrogen receptor", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1518217", "l": "Malignant Neuroendocrine Cell with Abundant Cytoplasm", "d": [], "t": []}, {"i": "NCIT:C36917", "l": "Malignant Neuroendocrine Cell with Abundant Cytoplasm", "d": [], "t": []}], "preferred_name": "Malignant Neuroendocrine Cell with Abundant Cytoplasm", "taxa": []}
{"type": "biolink:Cell", "ic": 84.83823963392128, "identifiers": [{"i": "CL:0002488", "l": "trophoblast giant cell", "d": ["A trophoblast cell that has a large volume of cytoplasm, is polyploid and is usually mononuclear but is also occasionally multi-nucleate. This cell type is important in establishing maternal physiology and remodeling of the vasculature of the placenta."], "t": []}], "preferred_name": "trophoblast giant cell", "taxa": []}
{"type": "biolink:Cell", "ic": 73.26332733876373, "identifiers": [{"i": "CL:0000782", "l": "myeloid dendritic cell", "d": ["A dendritic cell of the myeloid lineage."], "t": []}], "preferred_name": "myeloid dendritic cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5157434", "l": "CD3+CD26+ cells | Blood | Cell markers", "d": [], "t": []}], "preferred_name": "CD3+CD26+ cells | Blood | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0002510", "l": "CD103-negative, langerin-positive lymph node dendritic cell", "d": ["A langerin-positive lymph node dendritic cell that is CD103-negative and CD11b-high."], "t": []}], "preferred_name": "CD103-negative, langerin-positive lymph node dendritic cell", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "CL:0000253", "l": "eurydendroid cell", "d": [], "t": []}], "preferred_name": "eurydendroid cell", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "CL:0017010", "l": "hillock cell of urethral epithelium", "d": ["A hillock cell that is part of the urethra."], "t": []}], "preferred_name": "hillock cell of urethral epithelium", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1440374", "l": "CD98+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:1372948008", "l": "", "d": [], "t": []}], "preferred_name": "CD98+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C6021829", "l": "Blasts.HLA-DR+", "d": [], "t": []}], "preferred_name": "Blasts.HLA-DR+", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0009051", "l": "T cell of anorectum", "d": ["A T cell that is located in the anorectum."], "t": []}], "preferred_name": "T cell of anorectum", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5667076", "l": "Autologous IL-7/CCL19-expressing Anti-GM2 CAR T Cells NIB-101", "d": [], "t": []}, {"i": "NCIT:C186667", "l": "Autologous IL-7/CCL19-expressing Anti-GM2 CAR T Cells NIB-101", "d": ["A preparation of autologous T-lymphocytes that have been genetically modified to express a chimeric antigen receptor (CAR) targeting the tumor-associated antigen (TAA) ganglioside GM2 (GM2) and producing the immune regulators interleukin-7 (IL-7) and C-C motif chemokine 19 (CCL19) using PRIME (proliferation-inducing and migration-enhancing) technology, with potential immunostimulating and antineoplastic activities. Upon administration, autologous IL-7/CCL19-expressing anti-GM2 CAR T-cells NIB-101 target and bind to GM2-expressing tumor cells, thereby inducing selective toxicity in GM2-expressing tumor cells. In addition, as IL-7 promotes the proliferation and survival of T-cells and CCL19 enhances the migration of host T-cells and dendritic cells (DCs), the production of IL-7 and CCL19 by NIB-101 allows for enhanced trafficking and accumulation of the PRIME CAR-T cells and other endogenous immune cells, including T-cells and DCs in tumor tissues. This further activates the host immune system to induce anti-tumor immune responses to various cancer antigens and against tumor cells lacking the CAR target antigen. GM2, a type of glycosphingolipid, is overexpressed on the surface of many cancer cells, such as multiple myeloma (MM) cells and neuroblastoma cells."], "t": []}], "preferred_name": "Autologous IL-7/CCL19-expressing Anti-GM2 CAR T Cells NIB-101", "taxa": []}
{"type": "biolink:Cell", "ic": 92.76600187037766, "identifiers": [{"i": "CL:4033037", "l": "mucus secreting cell of tracheobronchial tree submucosal gland", "d": ["A mucus secreting cell of a submucosal gland of the tracheobronchial tree."], "t": []}], "preferred_name": "mucus secreting cell of tracheobronchial tree submucosal gland", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C4086900", "l": "Therapeutic Dendritic Cells/Cytokine-induced Killer Cells", "d": [], "t": []}, {"i": "NCIT:C123819", "l": "Therapeutic Dendritic Cells/Cytokine-induced Killer Cells", "d": ["A preparation of autologous dendritic cells (DC) mixed with cytokine-induced killer (CIK) cells (DC-CIK), with potential immunopotentiating and antineoplastic activities. DCs were obtained ex vivo by incubation of peripheral blood lymphocytes (PBLs) with granulocyte-macrophage colony-stimulating factor stimulating factor (GM-CSF or CSF2), tumor necrosis factor (TNF), and interleukin (IL)-24 and were sensitized with tumor-associated antigens (TAAs). Cytokine-induced killer (CIK) cells are immune effector cells with both T-cell and natural killer (NK) cell like phenotype. CIKs are non-major histocompatibility complex (MHC)-restricted, NK-like T-lymphocytes, which express both CD3, a T-cell surface marker, and CD56, a natural killer cell surface marker, and have been generated ex vivo by incubation of peripheral blood lymphocytes (PBLs) with anti-CD3 monoclonal antibody, IL-2, IL-1 alpha, and interferon gamma (IFN-gamma) and then expanded. Upon co-culture of DCs and CIKs, and administration of DC-CIK cells into the patient, the DCs are able to stimulate the immune response to exert a specific anti-tumor immune response, while the CIK cells exert direct oncolytic activity."], "t": []}], "preferred_name": "Therapeutic Dendritic Cells/Cytokine-induced Killer Cells", "taxa": []}
{"type": "biolink:Cell", "ic": 77.82747199602274, "identifiers": [{"i": "CL:1000274", "l": "trophectodermal cell", "d": ["An extraembryonic cell that is part of the trophectoderm, representing the first lineage to differentiate in the embryo. This cell is crucial for implantation into the uterine wall and differentiates into trophoblast cells, which contribute to placenta formation and facilitate maternal-fetal nutrient and signal exchange."], "t": []}], "preferred_name": "trophectodermal cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1522260", "l": "Mouse Fibroblast", "d": [], "t": []}, {"i": "NCIT:C22700", "l": "Mouse Fibroblast", "d": [], "t": []}], "preferred_name": "Mouse Fibroblast", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0945933", "l": "CD45+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:732272000", "l": "", "d": [], "t": []}], "preferred_name": "CD45+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C2334089", "l": "Epithelial cell of thyroid gland", "d": [], "t": []}], "preferred_name": "Epithelial cell of thyroid gland", "taxa": []}
{"type": "biolink:Cell", "ic": 82.16838616155795, "identifiers": [{"i": "UMLS:C1706983", "l": "Bone Marrow Stem Cell with Some Commitment to Monocytic Differentiation", "d": [], "t": []}, {"i": "NCIT:C42780", "l": "Bone Marrow Stem Cell with Some Commitment to Monocytic Differentiation", "d": ["A primitive, undifferentiated blood cell which can undergo division and tends to give rise to a blood cell of the monocyte lineage."], "t": []}], "preferred_name": "Bone Marrow Stem Cell with Some Commitment to Monocytic Differentiation", "taxa": []}
{"type": "biolink:Cell", "ic": 84.21065366064373, "identifiers": [{"i": "CL:0002005", "l": "CD34-positive, CD38-positive megakaryocyte erythroid progenitor cell", "d": ["A megakaryocyte erythroid progenitor cell is CD34-positive, CD38-positive and is IL3-receptor alpha-negative and CD45RA-negative."], "t": []}], "preferred_name": "CD34-positive, CD38-positive megakaryocyte erythroid progenitor cell", "taxa": []}
{"type": "biolink:Cell", "ic": 59.758011302778854, "identifiers": [{"i": "CL:1001509", "l": "glycinergic neuron", "d": ["The neurons that utilize glycine as a neurotransmitter."], "t": []}], "preferred_name": "glycinergic neuron", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4696655", "l": "CD3+CD8+CD28+HLA-DR+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:1373271005", "l": "", "d": [], "t": []}], "preferred_name": "CD3+CD8+CD28+HLA-DR+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5157239", "l": "CD10+CD20+ | White blood cells | Cell markers", "d": [], "t": []}], "preferred_name": "CD10+CD20+ | White blood cells | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4518156", "l": "Population of all spermatozoa with abnormal head size in portion of fluid", "d": [], "t": []}, {"i": "SNOMEDCT:725225001", "l": "", "d": [], "t": []}], "preferred_name": "Population of all spermatozoa with abnormal head size in portion of fluid", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5154299", "l": "Band form neutrophils | Cerebral spinal fluid | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Band form neutrophils | Cerebral spinal fluid | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5853935", "l": "Chimeric Antigen Receptor T Cells targeting CD7", "d": [], "t": []}], "preferred_name": "Chimeric Antigen Receptor T Cells targeting CD7", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1440393", "l": "Myeloperoxidase cells", "d": [], "t": []}], "preferred_name": "Myeloperoxidase cells", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4047023", "l": "intestinal lamina propria fibroblast", "d": ["A fibroblast located in the lamina propria of the intestinal mucosa. This cell expresses PDGFRα and CD81 and is negative for α-smooth muscle actin (α-SMA). This cell is predominantly located in the small intestine adjacent to myofibroblasts surrounding the crypts. It is capable of synthesizing extracellular matrix components and structural proteins such as collagen and elastin."], "t": []}], "preferred_name": "intestinal lamina propria fibroblast", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C6056204", "l": "Epidermal Growth Factor Receptor variant III (EGFRvIII) chimeric antigen receptor T cells", "d": [], "t": []}], "preferred_name": "Epidermal Growth Factor Receptor variant III (EGFRvIII) chimeric antigen receptor T cells", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0333804", "l": "Stomatocyte (cell)", "d": [], "t": []}, {"i": "SNOMEDCT:10636005", "l": "", "d": [], "t": []}], "preferred_name": "Stomatocyte (cell)", "taxa": []}
{"type": "biolink:Cell", "ic": 71.06400748151069, "identifiers": [{"i": "UMLS:C1512992", "l": "Marginal Zone B-Lymphocyte", "d": [], "t": []}, {"i": "NCIT:C38729", "l": "Marginal Zone B-Lymphocyte", "d": ["A lymphocyte found in the marginal zones of lymphoid tissues. It has a naive B lymphoid lineage and plays an important role in the early phases of immune response with its ability to rapidly differentiate into an antibody secreting cell. These cells can directly activate T cells, interact with other antigen presenting cells, transporting and concentrating antigen during the course of T-dependent and T-independent immune responses."], "t": []}], "preferred_name": "Marginal Zone B-Lymphocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C0314593", "l": "Colony-forming unit of megakarocytic lineage", "d": [], "t": []}, {"i": "NCIT:C121478", "l": "Megakaryocyte Colony Forming Unit", "d": ["A unit of viable cell concentration defined as the minimum number of hematopoietic stem cells able to produce a detectable colony of megakaryocyte lineage cells."], "t": []}, {"i": "SNOMEDCT:445093009", "l": "", "d": [], "t": []}], "preferred_name": "Colony-forming unit of megakarocytic lineage", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0009067", "l": "vacuolated fetal-type enterocyte", "d": ["An enterocyte found in the small intestine of newborn mammals and characterized by the presence of an apical canalicular system (ACS) leading to production of large vacuoles, important for colostral macromolecule uptake. After birth, the vacuolated fetal-type enterocytes are replaced with enterocytes lacking an ACS."], "t": []}], "preferred_name": "vacuolated fetal-type enterocyte", "taxa": []}
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{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5833285", "l": "CD15 cells | Donor | Blood | Cell markers", "d": [], "t": []}], "preferred_name": "CD15 cells | Donor | Blood | Cell markers", "taxa": []}
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{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5690736", "l": "Gut-Associated Lymphoid Tissue M Cells", "d": [], "t": []}], "preferred_name": "Gut-Associated Lymphoid Tissue M Cells", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C4050617", "l": "Autologous HPV-16/18 E6/E7-specific TGF-beta-resistant T Lymphocytes", "d": [], "t": []}, {"i": "NCIT:C121537", "l": "Autologous HPV-16/18 E6/E7-specific TGF-beta-resistant T Lymphocytes", "d": ["A preparation of autologous transforming growth factor-beta (TGF-beta)-resistant cytotoxic T-lymphocytes (CTL) reactive to human papilloma virus (HPV) types 16 and 18 E6/E7 antigens, with potential antineoplastic activity. Autologous T-lymphocytes from a HPV-positive cancer patient are exposed to and stimulated with dendritic cells (DCs) loaded with the HPV-16/18 proteins E6 and E7. In turn, the HPV-16/18 E6/E7-specific T-lymphocytes are transduced with a retroviral vector expressing a dominant-negative mutant of type II transforming growth factor (TGF)-beta receptor, which blocks signaling mediated by all three TGF-beta isoforms. Following re-administration to patients with HPV-positive tumors, the HPV-16/18 E6/E7-specific TGF-beta-resistant T lymphocytes target HPV16/18 E6/E7-positive cells, which may result in a specific cytotoxic T-lymphocyte (CTL) response, followed by cell lysis and the inhibition of tumor cell proliferation. Tumors expressing TGF-beta inhibit T-lymphocyte activation and expansion."], "t": []}], "preferred_name": "Autologous HPV-16/18 E6/E7-specific TGF-beta-resistant T Lymphocytes", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C2329214", "l": "Neurogliaform cell of cerebral cortex", "d": [], "t": []}], "preferred_name": "Neurogliaform cell of cerebral cortex", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0333809", "l": "Microcytic hypochromic erythrocyte", "d": [], "t": []}, {"i": "SNOMEDCT:62570005", "l": "", "d": [], "t": []}], "preferred_name": "Microcytic hypochromic erythrocyte", "taxa": []}
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{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5421165", "l": "Lenzumestrocel", "d": [], "t": []}, {"i": "NCIT:C175108", "l": "Lenzumestrocel", "d": [], "t": []}], "preferred_name": "Lenzumestrocel", "taxa": []}
{"type": "biolink:Cell", "ic": 67.555666079601, "identifiers": [{"i": "CL:0000673", "l": "Kenyon cell", "d": ["An intrinsic neuron of the mushroom body of arthropods and annelids. They have tightly packed, cytoplasm-poor cell bodies."], "t": []}], "preferred_name": "Kenyon cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4322731", "l": "CD22+ B lymphocyte", "d": [], "t": []}], "preferred_name": "CD22+ B lymphocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 86.30756602822301, "identifiers": [{"i": "CL:0000179", "l": "progesterone secreting cell", "d": ["Any secretory cell that is capable of some progesterone secretion."], "t": []}], "preferred_name": "progesterone secreting cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0001202", "l": "CD86-positive plasmablast", "d": ["A plasmablast that is CD86-positive."], "t": []}], "preferred_name": "CD86-positive plasmablast", "taxa": []}
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{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0003029", "l": "M2 retinal ganglion cell", "d": ["A monostratified retinal ganglion cell that has a small soma, a small dendrite field with a dense dendrite arbor, and post synaptic terminals in sublaminer layer S2 and S3."], "t": []}], "preferred_name": "M2 retinal ganglion cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4033162", "l": "myenteric ganglion of small intestine VIP neuron", "d": ["An enteric neuron that has the soma located in the myenteric ganglion of the small intestine and expresses the marker vasoactive intestinal peptide (VIP)."], "t": []}], "preferred_name": "myenteric ganglion of small intestine VIP neuron", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "UMLS:C1511762", "l": "Mouse Dendritic Cell", "d": [], "t": []}, {"i": "NCIT:C22596", "l": "Mouse Dendritic Cell", "d": [], "t": []}], "preferred_name": "Mouse Dendritic Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1512336", "l": "HeLa S3", "d": [], "t": []}, {"i": "NCIT:C20227", "l": "HeLa S3", "d": ["HeLa S3 is a clonal derivative of the parent HeLa line. S3 was cloned in 1955 by T.T. Puck, P.I. Marcus, and S.J. Cieciura. This line can be adapted to grow in suspension."], "t": []}], "preferred_name": "HeLa S3", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5983501", "l": "Macitegtagene Autoleucel", "d": [], "t": []}, {"i": "NCIT:C211716", "l": "Macitegtagene Autoleucel", "d": [], "t": []}], "preferred_name": "Macitegtagene Autoleucel", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5419828", "l": "SARS-CoV-2 Antigen-specific Cytotoxic T-lymphocytes", "d": [], "t": []}, {"i": "NCIT:C172750", "l": "SARS-CoV-2 Antigen-specific Cytotoxic T-lymphocytes", "d": ["A population of cytotoxic T-lymphocytes (CTLs) that are specifically reactive to SARS-CoV-2, with potential antiviral activity. Upon administration of the SARS-CoV-2 antigen-specific CTLs, these CTLs target and lyse the SARS-CoV-2-infected cells."], "t": []}], "preferred_name": "SARS-CoV-2 Antigen-specific Cytotoxic T-lymphocytes", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0009108", "l": "lymphatic endothelial cell of subcapsular sinus floor", "d": ["A lymphatic endothelial cell located in the subcapsular sinus floor of a lymph node. In human, it's characterized by a unique marker expression (TNFRSF9+)."], "t": []}], "preferred_name": "lymphatic endothelial cell of subcapsular sinus floor", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:1000377", "l": "dense-core granulated cell of epithelium of trachea", "d": ["A Feyrter cell that is part of the epithelium of trachea."], "t": []}, {"i": "UMLS:C2323694", "l": "Dense-core granulated cell of epithelium of trachea", "d": [], "t": []}], "preferred_name": "dense-core granulated cell of epithelium of trachea", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5395463", "l": "Autologous cultured chondrocyte 30 million unit/mL conventional release intraarticular implant", "d": [], "t": []}, {"i": "SNOMEDCT:840613000", "l": "", "d": [], "t": []}], "preferred_name": "Autologous cultured chondrocyte 30 million unit/mL conventional release intraarticular implant", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4079026", "l": "sacral dorsal root ganglion RET neuron", "d": ["A non-peptidergic nociceptor whose soma is located in the sacral dorsal root ganglion and that expresses the receptor tyrosine kinase RET (encoded by RET). This neuron is distinguished from peptidergic nociceptors by its dependence on glial cell-derived neurotrophic factor family ligands rather than nerve growth factor, and in rodents it characteristically binds isolectin B4. In human DRG, RET-immunoreactive neurons constitute approximately 46% of TrkA-positive neurons, a significantly higher proportion than the 23% observed in mouse (Rostock et al. 2018, PMID:29229553), indicating an expanded non-peptidergic nociceptor compartment in humans."], "t": []}], "preferred_name": "sacral dorsal root ganglion RET neuron", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1717525", "l": "Acute leukemia markers", "d": [], "t": []}], "preferred_name": "Acute leukemia markers", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:3000003", "l": "sympathetic cholinergic neuron", "d": ["A type of autonomic neuron that releases acetylcholine."], "t": []}], "preferred_name": "sympathetic cholinergic neuron", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5157321", "l": "CD158 cells | Blood | Cell markers", "d": [], "t": []}], "preferred_name": "CD158 cells | Blood | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "CL:4052021", "l": "granzyme K-associated CD8 T cell", "d": ["A CD8 T cell characterized by high expression of Granzyme K (GZMK). This cell is enriched in both inflamed tissues, such as synovial tissue in rheumatoid arthritis and respiratory tissues during COVID-19, as well as non-inflamed tissues like the gut and kidneys. Unlike highly cytotoxic GZMB+ CD8+ T cell, GZMK+ CD8+ T cell exhibits lower direct cytotoxic potential, and is involved in producing pro-inflammatory cytokines such as IFN-γ and TNF-α."], "t": []}], "preferred_name": "granzyme K-associated CD8 T cell", "taxa": []}
{"type": "biolink:Cell", "ic": 84.21065366064373, "identifiers": [{"i": "CL:0001006", "l": "dermal dendritic cell", "d": ["Dermal dendritic cell is a conventional dendritic cell that is CD11b-positive, CD205-positive and CD8 alpha-negative."], "t": []}], "preferred_name": "dermal dendritic cell", "taxa": []}
{"type": "biolink:Cell", "ic": 84.21065366064373, "identifiers": [{"i": "CL:0002062", "l": "pulmonary alveolar type 1 cell", "d": ["A squamous pulmonary alveolar epithelial cell that is flattened and branched. A pulmonary alveolar type 1 cell covers more than 98% of the alveolar surface. This large cell has thin (50-100 nm) cytoplasmic extensions to form the air-blood barrier essential for normal gas exchange."], "t": []}], "preferred_name": "pulmonary alveolar type 1 cell", "taxa": []}
{"type": "biolink:Cell", "ic": 80.61184433509295, "identifiers": [{"i": "CL:0000788", "l": "naive B cell", "d": ["A naive B cell is a mature B cell that has the phenotype surface IgD-positive, surface IgM-positive, CD20-positive, CD27-negative and that has not yet been activated by antigen in the periphery."], "t": []}], "preferred_name": "naive B cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5219171", "l": "Leukocytes|PrThr|Urine", "d": [], "t": []}], "preferred_name": "Leukocytes|PrThr|Urine", "taxa": []}
{"type": "biolink:Cell", "ic": 90.871710685482, "identifiers": [{"i": "CL:0001062", "l": "effector memory CD8-positive, alpha-beta T cell, terminally differentiated", "d": ["A CD8-positive, alpha beta memory T cell with the phenotype CD45RA-positive, CD45RO-negative, and CCR7-negative."], "t": []}], "preferred_name": "effector memory CD8-positive, alpha-beta T cell, terminally differentiated", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0333719", "l": "Anuclear squame", "d": [], "t": []}, {"i": "SNOMEDCT:85313000", "l": "", "d": [], "t": []}], "preferred_name": "Anuclear squame", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5196052", "l": "Human Cord Blood Hematopoietic Progenitor Cell 900000000 in 25 mL INTRAVENOUS SOLUTION [HEMATOPOIETIC PROGENITOR CELLS, CORD BLOOD]", "d": [], "t": []}], "preferred_name": "Human Cord Blood Hematopoietic Progenitor Cell 900000000 in 25 mL INTRAVENOUS SOLUTION [HEMATOPOIETIC PROGENITOR CELLS, CORD BLOOD]", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5163708", "l": "Erythrocytes | Blood | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Erythrocytes | Blood | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C2326176", "l": "Set of serotoninergic cells", "d": [], "t": []}], "preferred_name": "Set of serotoninergic cells", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5157357", "l": "CD19+CD38+IgM- cells | Blood | Cell markers", "d": [], "t": []}], "preferred_name": "CD19+CD38+IgM- cells | Blood | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C6063348", "l": "CD7+CD7-CD26- cell", "d": [], "t": []}, {"i": "SNOMEDCT:1373217000", "l": "", "d": [], "t": []}], "preferred_name": "CD7+CD7-CD26- cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4518159", "l": "Population of all progressive spermatozoa in portion of fluid", "d": [], "t": []}, {"i": "SNOMEDCT:726585007", "l": "", "d": [], "t": []}], "preferred_name": "Population of all progressive spermatozoa in portion of fluid", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5417706", "l": "Allogeneic Glial Progenitor Cells", "d": [], "t": []}], "preferred_name": "Allogeneic Glial Progenitor Cells", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C6050244", "l": "Ristoglogene Autogetemcel", "d": [], "t": []}, {"i": "NCIT:C216053", "l": "Ristoglogene Autogetemcel", "d": [], "t": []}], "preferred_name": "Ristoglogene Autogetemcel", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0546493", "l": "P.B. eosinophilic myelocyte", "d": [], "t": []}], "preferred_name": "P.B. eosinophilic myelocyte", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5157520", "l": "CD3-CD16+CD56+ (Natural killer) cells | Bone marrow | Cell markers", "d": [], "t": []}], "preferred_name": "CD3-CD16+CD56+ (Natural killer) cells | Bone marrow | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4033151", "l": "nodose ganglion PVALB neuron", "d": ["A sensory neuron that has the soma located in the nodose ganglion and expresses the marker parvalbumin (PVALB)."], "t": []}], "preferred_name": "nodose ganglion PVALB neuron", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C3658291", "l": "Adult Germline Stem Cells", "d": [], "t": []}, {"i": "MESH:D000072956", "l": "Adult Germline Stem Cells", "d": [], "t": []}], "preferred_name": "Adult Germline Stem Cells", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0002555", "l": "fibroblast of mammary gland", "d": ["A fibroblast that is part of the mammary gland."], "t": []}], "preferred_name": "fibroblast of mammary gland", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5382746", "l": "CD107a+b expressing HLA-A1 Cytomegalovirus specific CD8 cells | Blood | Cell markers", "d": [], "t": []}], "preferred_name": "CD107a+b expressing HLA-A1 Cytomegalovirus specific CD8 cells | Blood | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1267825", "l": "T lymphocyte positive for both CD4 antigen and HLA-DR antigen", "d": [], "t": []}, {"i": "SNOMEDCT:115405007", "l": "", "d": [], "t": []}], "preferred_name": "T lymphocyte positive for both CD4 antigen and HLA-DR antigen", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5173438", "l": "Monocytes | Synovial fluid | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Monocytes | Synovial fluid | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1511009", "l": "BG04", "d": [], "t": []}, {"i": "NCIT:C20236", "l": "BG04", "d": ["Provider: BresaGen, Inc., Athens, GA. Information from provider and not independently verified by NIH: Cells are positive for cell markers SSEA-3, SSEA-4, TRA 1-60, TRA 1-81, Oct-4, and alkaline phosphatase; Cells are negative for the cell marker SSEA1. This cell line meets the criteria for the use of human embryonic stem cells by federally funded researchers."], "t": []}], "preferred_name": "BG04", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4304630", "l": "Population of all acanthocytes in portion of fluid", "d": [], "t": []}, {"i": "SNOMEDCT:719690001", "l": "", "d": [], "t": []}], "preferred_name": "Population of all acanthocytes in portion of fluid", "taxa": []}
{"type": "biolink:Cell", "ic": 92.76600187037766, "identifiers": [{"i": "UMLS:C1881594", "l": "Malignant Small Germ Cell", "d": [], "t": []}, {"i": "NCIT:C61386", "l": "Malignant Small Germ Cell", "d": [], "t": []}], "preferred_name": "Malignant Small Germ Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 84.83823963392128, "identifiers": [{"i": "CL:0002192", "l": "metamyelocyte", "d": ["A eosinophil precursor in the granulocytic series, being a cell intermediate in development between a myelocyte and a band form cell. The nucleus becomes indented where the indentation is smaller than half the distance to the farthest nuclear margin; chromatin becomes coarse and clumped; specific granules predominate while primary granules are rare."], "t": []}], "preferred_name": "metamyelocyte", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5157618", "l": "CD56 cells | Blood | Cell markers", "d": [], "t": []}], "preferred_name": "CD56 cells | Blood | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4072036", "l": "PAX6 GABAergic interneuron (Homo sapiens)", "d": ["A transcriptomically distinct GABAergic neuron located in the cerebral cortex that expresses the transcript PAX6. The standard transcriptomic reference data for this cell type can be found on the CellxGene census under the collection: 'Transcriptomic cytoarchitecture reveals principles of human neocortex organization', dataset: 'Supercluster: CGE-derived interneurons', Author Categories: 'CrossArea_subclass', clusters PAX"], "t": []}], "preferred_name": "PAX6 GABAergic interneuron (Homo sapiens)", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0682689", "l": "neuron type", "d": [], "t": []}], "preferred_name": "neuron type", "taxa": []}
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{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0009036", "l": "appendix macrophage", "d": ["A macrophage located in the vermiform appendix."], "t": []}], "preferred_name": "appendix macrophage", "taxa": []}
{"type": "biolink:Cell", "ic": 61.69624927280271, "identifiers": [{"i": "UMLS:C1513943", "l": "Neoplastic Connective and Soft Tissue Spindle Cell", "d": [], "t": []}, {"i": "NCIT:C36954", "l": "Neoplastic Connective and Soft Tissue Spindle Cell", "d": [], "t": []}], "preferred_name": "Neoplastic Connective and Soft Tissue Spindle Cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5977363", "l": "Cells.235a", "d": [], "t": []}], "preferred_name": "Cells.235a", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C3826624", "l": "Cancer cells--Motility", "d": [], "t": []}], "preferred_name": "Cancer cells--Motility", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4307108", "l": "MOL NN_4 Sspo mature myelinating oligodendrocyte (Mmus)", "d": ["A mature myelinating oligodendrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Mog (Mmus), Anln (Mmus), Gm32633 (Mmus). It is distinguished from other MOL NN_4 cells by expression of Sspo, Selenop. These cells are located in the Isocortex, brain . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5288 MOL NN_4."], "t": []}], "preferred_name": "MOL NN_4 Sspo mature myelinating oligodendrocyte (Mmus)", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C3656689", "l": "B cell+T cell", "d": [], "t": []}], "preferred_name": "B cell+T cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4323914", "l": "Set of cranial neural crest cells", "d": [], "t": []}], "preferred_name": "Set of cranial neural crest cells", "taxa": []}
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{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1440314", "l": "CD14+CD45+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:1373147007", "l": "", "d": [], "t": []}], "preferred_name": "CD14+CD45+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C6021824", "l": "Cells.CD123+CD19+", "d": [], "t": []}], "preferred_name": "Cells.CD123+CD19+", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5216286", "l": "Neutrophils.band form|NCnc|Pt|Body fld", "d": [], "t": []}], "preferred_name": "Neutrophils.band form|NCnc|Pt|Body fld", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0009002", "l": "inflammatory cell", "d": ["Any cell participating in the inflammatory response to a foreign substance, e.g. neutrophil, macrophage."], "t": []}], "preferred_name": "inflammatory cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1978609", "l": "Cells.CD3+CD57+", "d": [], "t": []}, {"i": "SNOMEDCT:1373013006", "l": "", "d": [], "t": []}], "preferred_name": "Cells.CD3+CD57+", "taxa": []}
{"type": "biolink:Cell", "ic": 79.64650900338474, "identifiers": [{"i": "CL:4300367", "l": "oligodendrocyte (Mmus)", "d": ["A oligodendrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Cldn11 (Mmus), Gjc3 (Mmus). Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Subclass:327 Oligo NN."], "t": []}], "preferred_name": "oligodendrocyte (Mmus)", "taxa": []}
{"type": "biolink:Cell", "ic": 90.871710685482, "identifiers": [{"i": "UMLS:C3642320", "l": "Immature Malignant Mast Cell", "d": [], "t": []}, {"i": "NCIT:C37063", "l": "Immature Malignant Mast Cell", "d": [], "t": []}], "preferred_name": "Immature Malignant Mast Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5666877", "l": "WU-CART-007", "d": [], "t": []}, {"i": "NCIT:C182072", "l": "Allogeneic Anti-CD7 CAR-T Cells WU-CART-007", "d": ["A preparation of off-the-shelf (OTS) donor-derived T-lymphocytes that have been genetically engineered to express a chimeric antigen receptor (CAR) directed against the tumor-associated antigen (TAA) CD7, with potential immunostimulating and antineoplastic activities. Upon intravenous administration, the allogeneic anti-CD7 CAR-T cells WU-CART-007 specifically recognize and bind to CD7-expressing tumor cells, resulting in specific T-cell-mediated tumor cell lysis. CD7 is a transmembrane glycoprotein expressed by T-cells and natural killer (NK) cells and their precursors. It is expressed in the majority of lymphoblastic T-cell leukemias and lymphomas and in a subset of peripheral T-cell lymphomas."], "t": []}], "preferred_name": "WU-CART-007", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4300406", "l": "Cells.chromosome region 11q22.3", "d": [], "t": []}], "preferred_name": "Cells.chromosome region 11q22.3", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5163751", "l": "Erythrocytes.ghost cells | Blood | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Erythrocytes.ghost cells | Blood | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5960084", "l": "Litgenprostucel-L", "d": [], "t": []}, {"i": "NCIT:C206934", "l": "Litgenprostucel-L", "d": [], "t": []}], "preferred_name": "Litgenprostucel-L", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1182645", "l": "Ciliary epithelial cell", "d": [], "t": []}], "preferred_name": "Ciliary epithelial cell", "taxa": []}
{"type": "biolink:Cell", "ic": 68.93024740242504, "identifiers": [{"i": "CL:0000625", "l": "CD8-positive, alpha-beta T cell", "d": ["A T cell expressing an alpha-beta T cell receptor and the CD8 coreceptor."], "t": []}], "preferred_name": "CD8-positive, alpha-beta T cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5184818", "l": "Variant lymphocytes | Blood | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Variant lymphocytes | Blood | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4310132", "l": "STRd D2 Matrix medium spiny neuron (Primate)", "d": ["A matrix D2 medium spiny neuron of the Primates brain. These cells are located in the striatum . Reference transcriptomic data for this type can be found in the dataset/taxonomy - HMBA Basal Ganglia Consensus Taxonomy in cell set Group:STRd D2 Matrix MSN."], "t": []}], "preferred_name": "STRd D2 Matrix medium spiny neuron (Primate)", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0001057", "l": "myeloid dendritic cell, human", "d": ["A myeloid dendritic cell with the phenotype HLA-DRA-positive and CD14-negative."], "t": []}], "preferred_name": "myeloid dendritic cell, human", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5556555", "l": "Autologous Anti-GFRa4 CAR-TCR-zeta-4-1BB-expressing T-cells", "d": [], "t": []}, {"i": "NCIT:C180681", "l": "Autologous Anti-GFRa4 CAR-TCR-zeta-4-1BB-expressing T-cells", "d": ["A preparation of autologous T-lymphocytes that have been transduced with a lentiviral vector to express a chimeric antigen receptor (CAR) consisting of an anti-glial-derived neurotrophic factor (GDNF) family receptor alpha 4 (GFRa4) single chain variable fragment (scFv), coupled to the zeta chain of the human T-cell receptor (TCR/CD3zeta) and the co-stimulatory molecule 4-1BB (CD137), with potential immunostimulating and antineoplastic activities. Upon re-introduction into the patient, the autologous anti-GFRa4 CAR-TCR-zeta-4-1BB-expressing T-cells target and bind to GFRa4-expressing tumor cells. This results in a cytotoxic T-lymphocyte (CTL) response against GFRa4-expressing tumor cells, resulting in tumor cell lysis. GFRa4 is highly expressed in metastatic medullary thyroid cancer (MTC) and also normally expressed in parafollicular cells within the thyroid and thymus."], "t": []}], "preferred_name": "Autologous Anti-GFRa4 CAR-TCR-zeta-4-1BB-expressing T-cells", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "CL:1001576", "l": "oral mucosa squamous cell", "d": ["Squamous cell of oral epithelium."], "t": []}], "preferred_name": "oral mucosa squamous cell", "taxa": []}
{"type": "biolink:Cell", "ic": 79.35380886648232, "identifiers": [{"i": "CL:0008039", "l": "lower motor neuron", "d": ["The motor neurons of vertebrates that directly innervate skeletal muscles. They receive input from upper motor neurons."], "t": []}], "preferred_name": "lower motor neuron", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5184400", "l": "Unidentified cells | Pleural fluid | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Unidentified cells | Pleural fluid | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C6065113", "l": "Autologous CD34+ hematopoietic stem and progenitor cells edited by CRISPR/CAS12a at the HBG1 and HBG2 promoters", "d": [], "t": []}], "preferred_name": "Autologous CD34+ hematopoietic stem and progenitor cells edited by CRISPR/CAS12a at the HBG1 and HBG2 promoters", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1718726", "l": "ZAP70+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:1373083000", "l": "", "d": [], "t": []}], "preferred_name": "ZAP70+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1276865", "l": "Entire hilar cell of ovary", "d": [], "t": []}, {"i": "SNOMEDCT:259185009", "l": "", "d": [], "t": []}], "preferred_name": "Entire hilar cell of ovary", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C2924225", "l": "CD45+CD103+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:1373146003", "l": "", "d": [], "t": []}], "preferred_name": "CD45+CD103+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C2323865", "l": "Non-spiny stellate cell of cerebral cortex", "d": [], "t": []}], "preferred_name": "Non-spiny stellate cell of cerebral cortex", "taxa": []}
{"type": "biolink:Cell", "ic": 92.76600187037766, "identifiers": [{"i": "CL:0002208", "l": "brush cell of bronchus", "d": ["A brush cell found in the epithelium of bronchus."], "t": []}, {"i": "UMLS:C2330872", "l": "Brush cell of epithelium of bronchus", "d": [], "t": []}], "preferred_name": "brush cell of bronchus", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0002578", "l": "mesenteric preadipocyte", "d": ["A preadipocyte found in mesenteric tissue."], "t": []}], "preferred_name": "mesenteric preadipocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1518314", "l": "Nevus Cell C-Type", "d": [], "t": []}, {"i": "NCIT:C36866", "l": "Nevus Cell C-Type", "d": [], "t": []}], "preferred_name": "Nevus Cell C-Type", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4033114", "l": "cervicothoracic ganglion TH neuron", "d": ["A sympathetic neuron that has the soma located in the cervicothoracic ganglion and expresses the marker tyrosine hydroxylase (TH)."], "t": []}], "preferred_name": "cervicothoracic ganglion TH neuron", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C6021987", "l": "Epithelial cells | Aspirate | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Epithelial cells | Aspirate | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": 83.63771255585968, "identifiers": [{"i": "CL:0002365", "l": "medullary thymic epithelial cell", "d": ["An epithelial cell of the medullary thymus. This cell type expresses a diverse range of tissue-specific antigens. This promiscuous gene expression is a cell-autonomous property of medullary epithelial cells and is maintained during the entire period of thymic T cell output."], "t": []}], "preferred_name": "medullary thymic epithelial cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0002641", "l": "epithelial cell of esophageal gland proper", "d": ["An epithelial cell of the esophageal gland proper."], "t": []}, {"i": "UMLS:C2327051", "l": "Epithelial cell of esophageal gland proper", "d": [], "t": []}], "preferred_name": "epithelial cell of esophageal gland proper", "taxa": []}
{"type": "biolink:Cell", "ic": 35.62569241894553, "identifiers": [{"i": "UMLS:C0007634", "l": "Cells", "d": [], "t": []}, {"i": "NCIT:C12508", "l": "Cell", "d": ["The smallest units of living structure capable of independent existence, composed of a membrane-enclosed mass of protoplasm and containing a nucleus or nucleoid."], "t": []}, {"i": "MESH:D002477", "l": "Cells", "d": [], "t": []}, {"i": "SNOMEDCT:4421005", "l": "", "d": [], "t": []}], "preferred_name": "Cells", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1440279", "l": "CD3+CD16+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:1373003003", "l": "", "d": [], "t": []}], "preferred_name": "CD3+CD16+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0002283", "l": "ecto-epithelial cell of viscerocranial mucosa", "d": ["An epithelial cell of the mucosa associated with facial skeleton."], "t": []}, {"i": "UMLS:C1182629", "l": "Ecto-epithelial cell of viscerocranial mucosa", "d": [], "t": []}], "preferred_name": "ecto-epithelial cell of viscerocranial mucosa", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5170951", "l": "Leukocytes other | Body fluid | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Leukocytes other | Body fluid | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5170935", "l": "Leukocytes | Pleural fluid | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Leukocytes | Pleural fluid | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0333737", "l": "Muciphage", "d": [], "t": []}, {"i": "SNOMEDCT:57068003", "l": "", "d": [], "t": []}], "preferred_name": "Muciphage", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C4744852", "l": "Autologous iC9-deltaNGFR-CD19CAR-CD3zeta-4-1BB-expressing T-lymphocytes", "d": [], "t": []}, {"i": "NCIT:C156479", "l": "Autologous iC9-deltaNGFR-CD19CAR-CD3zeta-4-1BB-expressing T-lymphocytes", "d": ["A preparation of autologous T-lymphocytes that have been transduced with a retroviral vector to express a chimeric antigen receptor (CAR) consisting of an anti-CD19 single chain variable fragment (scFv) fused to a human immunoglobulin G1 (IgG1) hinge and a CD8alpha transmembrane domain, linked to the co-stimulatory molecule 4-1BB (CD137) and the cytoplasmic portion of the zeta chain of the human T-cell receptor (CD3zeta), containing the apoptosis-inducible suicide gene human caspase 9 (iCASP9 or iC9), linked to a drug binding domain, and a truncated low-affinity nerve growth factor receptor (deltaNGFR), with potential immunostimulating and antineoplastic activities. The iC9 construct consists of the sequence of the human FK506-binding protein (FKBP12) with an F36V mutation, connected through a Ser-Gly-Gly-Gly-Ser linker to the gene-encoding human caspase 9, which is deleted of its endogenous caspase activation and recruitment domain. Upon transfusion, the iCasp9-deltaNGFR-CD19CAR-CD3zeta-4-1BB-expressing autologous T-lymphocytes target and bind to CD19-expressing neoplastic B-cells. Prior to administration, deltaNGFR is used to select the CAR19-transduced T-cells for further enrichment by flow cytometry using an anti-NGFR antibody."], "t": []}], "preferred_name": "Autologous iC9-deltaNGFR-CD19CAR-CD3zeta-4-1BB-expressing T-lymphocytes", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0949376", "l": "Perineuronal Oligodendroglia", "d": [], "t": []}], "preferred_name": "Perineuronal Oligodendroglia", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4307132", "l": "microglial cell (Mmus)", "d": ["A microglial cell of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of C1qa (Mmus), Tmem119 (Mmus). It is distinguished from other Immune cells by expression of C1qa, Tmem119. These cells are located in the Isocortex, brain . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5312 Microglia NN_1."], "t": []}], "preferred_name": "microglial cell (Mmus)", "taxa": []}
{"type": "biolink:Cell", "ic": 87.18682603146104, "identifiers": [{"i": "CL:0000509", "l": "gastrin secreting cell", "d": ["A peptide hormone secreting cell that secretes gastrin."], "t": []}, {"i": "UMLS:C0524983", "l": "Gastrin-Secreting Cells", "d": [], "t": []}, {"i": "NCIT:C12577", "l": "G-Cell", "d": ["A gastrin-producing enteroendocrine cell that is located in the gastric antrum."], "t": []}, {"i": "MESH:D019863", "l": "Gastrin-Secreting Cells", "d": [], "t": []}], "preferred_name": "gastrin secreting cell", "taxa": []}
{"type": "biolink:Cell", "ic": 67.94889746485862, "identifiers": [{"i": "CL:0000559", "l": "promonocyte", "d": ["A precursor in the monocytic series, being a cell intermediate in development between the monoblast and monocyte. This cell is CD11b-positive and has fine azurophil granules."], "t": []}], "preferred_name": "promonocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5555808", "l": "Anti-CD19 CAR-IL-18-expressing Autologous T-lymphocytes", "d": [], "t": []}, {"i": "NCIT:C179603", "l": "Autologous Anti-CD19 CAR-IL-18-expressing T-lymphocytes", "d": ["A preparation of autologous T-lymphocytes engineered to express a chimeric antigen receptor (CAR) specific for the tumor-associated antigen (TAA) cluster of differentiation 19 (CD19), and expressing the pro-inflammatory cytokine interleukin 18 (IL-18), with potential antineoplastic activity. Upon intravenous administration, autologous anti-CD19 CAR-IL-18-expressing T-lymphocytes target, bind to, and induce selective toxicity in CD19-expressing tumor cells. IL-18 promotes T-cell persistence and potentiates the immune response against tumor cells. CD19 is a B-cell-specific cell surface antigen overexpressed in B-cell lineage tumors. Incorporation of costimulatory signaling domains increases human T-cell function, expansion, and survival."], "t": []}, {"i": "NCIT:C203666", "l": "Anti-CD19 CAR-IL-18-expressing Autologous T-lymphocytes", "d": ["A preparation of autologous T-lymphocytes engineered to express a chimeric antigen receptor (CAR) specific for the tumor-associated antigen (TAA) cluster of differentiation 19 (CD19), and expressing the pro-inflammatory cytokine interleukin 18 (IL-18), with potential antineoplastic activity. Upon intravenous administration, anti-CD19 CAR-IL-18-expressing autologous T-lymphocytes target, bind to, and induce selective toxicity in CD19-expressing tumor cells. IL-18 promotes T-cell persistence and potentiates the immune response against tumor cells. CD19 is a B-cell-specific cell surface antigen overexpressed in B-cell lineage tumors. Incorporation of costimulatory signaling domains increases human T-cell function, expansion, and survival."], "t": []}], "preferred_name": "Anti-CD19 CAR-IL-18-expressing Autologous T-lymphocytes", "taxa": []}
{"type": "biolink:Cell", "ic": 74.24062392510156, "identifiers": [{"i": "CL:0000322", "l": "pulmonary alveolar epithelial cell", "d": ["An epithelial cell that lines the peripheral gas exchange region of the lungs of air-breathing vertebrates."], "t": []}], "preferred_name": "pulmonary alveolar epithelial cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5175153", "l": "Nucleated cells | Pleural fluid | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Nucleated cells | Pleural fluid | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5853464", "l": "Human autologous bone marrow derived osteoblastic cells", "d": [], "t": []}], "preferred_name": "Human autologous bone marrow derived osteoblastic cells", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C4724879", "l": "PD-1 knockout EBV-specific Cytotoxic T Lymphocytes", "d": [], "t": []}, {"i": "NCIT:C148180", "l": "PD-1 knockout EBV-specific Cytotoxic T Lymphocytes", "d": ["A preparation of Epstein-Barr virus (EBV) reactive cytotoxic T-lymphocytes (CTLs) in which the programmed cell death 1 (PD-1; PDCD1; CD279; programmed death-1) gene is deleted, with potential immunomodulating activity. Upon administration of the PD-1 knockout EBV-specific CTLs, these CTLs target and induce selective toxicity in EBV-positive cancer cells. This results in cell lysis and inhibition of cancer cell proliferation. Expression of PD-1, an inhibitory receptor expressed on activated T-cells, plays a key role in CTL suppression, T-cell exhaustion and CTL apoptosis. PD-1 knockout abrogates T-cell exhaustion and increases T-cell activity and cytotoxicity. EBV, a ubiquitous human herpesvirus, is associated with various cancer cell types."], "t": []}], "preferred_name": "PD-1 knockout EBV-specific Cytotoxic T Lymphocytes", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1317186", "l": "CD10+CD25+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:1372957002", "l": "", "d": [], "t": []}], "preferred_name": "CD10+CD25+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0009109", "l": "lymphatic endothelial cell of trabecula", "d": ["A lymphatic endothelial cell located in a lymph node trabecula."], "t": []}], "preferred_name": "lymphatic endothelial cell of trabecula", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1512138", "l": "ESO-1 Reactive Autologous Tumor Infiltrating Lymphocyte", "d": [], "t": []}, {"i": "NCIT:C38120", "l": "ESO-1 Reactive Autologous Tumor Infiltrating Lymphocyte", "d": ["Tumor infiltrating lymphocytes (TIL) isolated from a patient, exposed to the tumor-associated protein ESO-1 in vitro, and then transferred back to the same patient to target tumor cells expressing ESO-1. ESO-1 is a human self-antigen expressed by melanomas. The ESO-1 gene encodes several MHC class I- and MHC class II-restricted epitopes which may activate cytotoxic T-cell-mediated tumor destruction. (NCI04)"], "t": []}], "preferred_name": "ESO-1 Reactive Autologous Tumor Infiltrating Lymphocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 67.70038990231329, "identifiers": [{"i": "CL:0000469", "l": "ganglion mother cell", "d": ["A neural progenitor cell that is the daughter of a neuroblast (sensu arthopoda).  The progeny of ganglion mother cells develop into neurons, glia and (occasionally) epithelial cells."], "t": []}], "preferred_name": "ganglion mother cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:1001223", "l": "interlobulary vein endothelial cell", "d": ["Any endothelial cell that is part of some renal interlobular vein."], "t": []}], "preferred_name": "interlobulary vein endothelial cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0597032", "l": "Neoplastic Cell", "d": [], "t": []}], "preferred_name": "Neoplastic Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5909015", "l": "Latovetcel", "d": [], "t": []}, {"i": "NCIT:C203132", "l": "Latovetcel", "d": [], "t": []}], "preferred_name": "Latovetcel", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5886265", "l": "Cells.chromosome region 20q12 deletion", "d": [], "t": []}], "preferred_name": "Cells.chromosome region 20q12 deletion", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5556478", "l": "Dual-target CAR T Cells C-4-29", "d": [], "t": []}, {"i": "NCIT:C180586", "l": "Dual-target CAR T Cells C-4-29", "d": ["A preparation of human T-lymphocytes that have been genetically modified to express a dual-target CAR, with potential immunostimulating and antineoplastic activities. Upon administration, the dual-target CAR T cells C-4-29 recognize and kill tumor cells expressing the two as of yet undisclosed targets. This results in a cytotoxic T-lymphocyte (CTL) response against these tumor cells, thereby causing tumor cell lysis."], "t": []}], "preferred_name": "Dual-target CAR T Cells C-4-29", "taxa": []}
{"type": "biolink:Cell", "ic": 88.20185721311867, "identifiers": [{"i": "UMLS:C0229598", "l": "Structure of delta Cell of islet", "d": [], "t": []}, {"i": "NCIT:C38639", "l": "Delta Cell of the Pancreas", "d": ["A type of cell in the pancreatic islets that secretes somatostatin."], "t": []}, {"i": "SNOMEDCT:11815004", "l": "", "d": [], "t": []}], "preferred_name": "Structure of delta Cell of islet", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1440312", "l": "CD44+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:1372890003", "l": "", "d": [], "t": []}], "preferred_name": "CD44+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1522212", "l": "Mouse Alpha Cell", "d": [], "t": []}, {"i": "NCIT:C22641", "l": "Mouse Alpha Cell", "d": [], "t": []}], "preferred_name": "Mouse Alpha Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 92.76600187037766, "identifiers": [{"i": "UMLS:C0229614", "l": "Prolymphocyte (cell)", "d": [], "t": []}, {"i": "NCIT:C13119", "l": "Prolymphocyte", "d": ["A medium-sized round lymphocyte of B or T-cell lineage with prominent nucleoli.  It is an intermediate cell between the lymphoblast and the small, mature lymphocyte."], "t": []}, {"i": "SNOMEDCT:19394005", "l": "", "d": [], "t": []}], "preferred_name": "Prolymphocyte (cell)", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5167385", "l": "Histiocytes | Bone marrow | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Histiocytes | Bone marrow | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1267853", "l": "Lymphocyte positive for CD7 antigen and negative for CD3 antigen", "d": [], "t": []}, {"i": "SNOMEDCT:116840009", "l": "", "d": [], "t": []}], "preferred_name": "Lymphocyte positive for CD7 antigen and negative for CD3 antigen", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1257909", "l": "Diploid Cell", "d": [], "t": []}, {"i": "NCIT:C12949", "l": "Somatic Cell", "d": [], "t": []}], "preferred_name": "Diploid Cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5181335", "l": "Spermatozoa | Urine | Urinalysis", "d": [], "t": []}], "preferred_name": "Spermatozoa | Urine | Urinalysis", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1280543", "l": "Entire syncytial trophoblast", "d": [], "t": []}, {"i": "SNOMEDCT:256965005", "l": "", "d": [], "t": []}], "preferred_name": "Entire syncytial trophoblast", "taxa": []}
{"type": "biolink:Cell", "ic": 75.2337427109536, "identifiers": [{"i": "CL:0002427", "l": "resting double-positive thymocyte", "d": ["A double-positive, alpha-beta thymocyte that is small and not proliferating."], "t": []}], "preferred_name": "resting double-positive thymocyte", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1267976", "l": "Lymphocyte positive for CD86 antigen", "d": [], "t": []}, {"i": "SNOMEDCT:117416001", "l": "", "d": [], "t": []}], "preferred_name": "Lymphocyte positive for CD86 antigen", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5420764", "l": "BCMA-CD19 Compound CAR T Cells", "d": [], "t": []}, {"i": "NCIT:C174412", "l": "BCMA-CD19 Compound CAR T Cells", "d": ["A preparation of T-lymphocytes transduced with a lentiviral vector expressing a compound chimeric antigen receptor (cCAR) containing two distinct units of CARs, one specific for the tumor-associated antigen (TAA) B-cell maturation antigen (BCMA; tumor necrosis factor receptor superfamily member 17; TNFRSF17) and one specific for the TAA CD19, with potential immunomodulating and antineoplastic activities. Upon administration, the BCMA-CD19 cCAR T cells specifically and simultaneously target and bind to tumor cells expressing BCMA and/or CD19. This induces selective toxicity in tumor cells that express BCMA and/or CD19. BCMA, a tumor-specific antigen and a receptor for both a proliferation-inducing ligand (APRIL) and B-cell activating factor (BAFF), is a member of the tumor necrosis factor receptor superfamily (TNFRSF) and plays a key role in the survival of B-lymphocytes and plasma cells. BCMA is found on the surfaces of B-cells and is overexpressed on malignant plasma cells. CD19 is a B-cell-specific cell surface antigen overexpressed in B-cell lineage malignancies. Targeting two different antigens may improve coverage and protect against antigen escape and relapse as it is less likely for tumor cells to lose both antigens."], "t": []}], "preferred_name": "BCMA-CD19 Compound CAR T Cells", "taxa": []}
{"type": "biolink:Cell", "ic": 76.78008365410358, "identifiers": [{"i": "CL:0000500", "l": "follicular epithelial cell", "d": ["An epithelial somatic cell associated with a maturing oocyte."], "t": []}], "preferred_name": "follicular epithelial cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5171770", "l": "Lymphoma cells | Blood | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Lymphoma cells | Blood | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4030013", "l": "kidney loop of Henle long descending thin limb outer medulla epithelial cell", "d": ["Epithelial cell of the descending thin limb of the long loop (juxtamedullary) nephron that spans the outer medulla (inner stripe). It is known in some mammalian species that the long descending limb of the loop of Henle in the outer medulla selectively expresses the secreted activin-antagonist protein follistatin (Fst), the GPI-linked adhesion protein Cdh13, and the protein kinase Stk32a."], "t": []}], "preferred_name": "kidney loop of Henle long descending thin limb outer medulla epithelial cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0229618", "l": "Large lymphocyte", "d": [], "t": []}, {"i": "SNOMEDCT:54969003", "l": "", "d": [], "t": []}], "preferred_name": "Large lymphocyte", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0806036", "l": "Renal epithelial cell", "d": [], "t": []}, {"i": "SNOMEDCT:115593006", "l": "", "d": [], "t": []}], "preferred_name": "Renal epithelial cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1441375", "l": "Cells.total", "d": [], "t": []}], "preferred_name": "Cells.total", "taxa": []}
{"type": "biolink:Cell", "ic": 72.11981073685999, "identifiers": [{"i": "CL:0000488", "l": "visible light photoreceptor cell", "d": ["A photoreceptor cell that detects visible light."], "t": []}], "preferred_name": "visible light photoreceptor cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5815552", "l": "Skin-derived ABCB5-positive Mesenchymal Stem cells", "d": [], "t": []}, {"i": "NCIT:C199466", "l": "Allogeneic Skin-derived ABCB5-positive MSCs allo-APZ2-OTS", "d": ["A preparation of off-the-shelf (OTS) allogeneic human dermal ex-vivo expanded mesenchymal stromal cells (MSCs) expressing the ATP-binding cassette (ABC) efflux transporter, subfamily B, member 5 (ABCB5) that can potentially be used in the treatment of various skin-related and systemic inflammatory and degenerative conditions, such as recessive dystrophic epidermolysis bullosa (RDEB). Upon administration of the allo-APZ2-OTS, the MSCs are able to differentiate into several lineages, provide immunomodulatory activity, interact with various immune cells, such as macrophages, neutrophils and regulatory T-cells (Tregs), and are able to secrete various anti-inflammatory mediators and pro-angiogenic molecules. Altogether, allo-APZ2-OTS may contribute to inflammation control and tissue repair."], "t": []}], "preferred_name": "Skin-derived ABCB5-positive Mesenchymal Stem cells", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5908093", "l": "Fencabtagene Autoleucel", "d": [], "t": []}], "preferred_name": "Fencabtagene Autoleucel", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5667170", "l": "Sizavaleucel", "d": [], "t": []}], "preferred_name": "Sizavaleucel", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4052069", "l": "excretory duct cell of salivary gland", "d": ["A duct epithelial cell that is part of the excretory duct of the salivary gland, which transports saliva from the intralobular ductal system to the oral cavity. While primarily serving as a conduit, this cell may play a role in the saliva modification, contributing to its hypotonicity. In humans, this cell has a pseudostratified columnar shape."], "t": []}], "preferred_name": "excretory duct cell of salivary gland", "taxa": []}
{"type": "biolink:Cell", "ic": 83.63771255585968, "identifiers": [{"i": "NCIT:C12598", "l": "Oocyte", "d": ["The female gamete, germ cells in stages between the prophase of the first maturation division and the completion of the second maturation division."], "t": []}], "preferred_name": "Oocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 78.54651317367835, "identifiers": [{"i": "UMLS:C5856891", "l": "Therapeutic Mesenchymal Stem Cells", "d": [], "t": []}, {"i": "NCIT:C201556", "l": "Therapeutic Mesenchymal Stem Cells", "d": ["Any preparation of mesenchymal stem cells (MSCs)."], "t": []}], "preferred_name": "Therapeutic Mesenchymal Stem Cells", "taxa": []}
{"type": "biolink:Cell", "ic": 92.76600187037766, "identifiers": [{"i": "CL:0000308", "l": "metal ion accumulating cell", "d": [], "t": []}], "preferred_name": "metal ion accumulating cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0000379", "l": "sensory processing neuron", "d": [], "t": []}], "preferred_name": "sensory processing neuron", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1710678", "l": "Wolffian Duct Cell", "d": [], "t": []}, {"i": "NCIT:C43425", "l": "Wolffian Duct Cell", "d": ["A cell of the embryonic mesonephric duct. This duct connects the primitive kidney and urogenital sinus. In the presence of testosterone, it develops into the sperm collecting apparatus - epididymis, the vas deferens, and seminal vesicles. Without testosterone, it becomes vestigial."], "t": []}], "preferred_name": "Wolffian Duct Cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5173501", "l": "Mononuclear cells atypical | Blood | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Mononuclear cells atypical | Blood | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": 88.20185721311867, "identifiers": [{"i": "CL:0002212", "l": "type II muscle cell", "d": ["A fast muscle fiber cell that stores energy in the form of glycogen and creatine phosphate."], "t": []}], "preferred_name": "type II muscle cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C3272725", "l": "Mini-Gemistocyte", "d": [], "t": []}, {"i": "NCIT:C96345", "l": "Mini-Gemistocyte", "d": ["A neoplastic gemistocytic astrocyte characterized by a diminutive size, a single, eccentric nucleus, and a cytoplasmic droplet of eosinophilic material."], "t": []}], "preferred_name": "Mini-Gemistocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 92.76600187037766, "identifiers": [{"i": "CL:0002349", "l": "CD27-high, CD11b-low natural killer cell, mouse", "d": ["A natural killer cell that is CD27-high and CD11b-low."], "t": []}], "preferred_name": "CD27-high, CD11b-low natural killer cell, mouse", "taxa": []}
{"type": "biolink:Cell", "ic": 69.23096947192928, "identifiers": [{"i": "CL:0000568", "l": "amine precursor uptake and decarboxylation cell", "d": ["A cell that originates in the neural crest, that has certain cytochemical and ultrastructural characteristics and is found scattered throughout the body; types include melanocytes, the cells of the chromaffin system, and cells in the hypothalamus, hypophysis, thyroid, parathyroids, lungs, gastrointestinal tract, and pancreas. This cell type concentrates the amino acid precursors of certain amines and decarboxylate them, forming amines that function as regulators and neurotransmitters. This cell type produces substances such as epinephrine, norepinephrine, dopamine, serotonin, enkephalin, somatostatin, neurotensin, and substance P, the actions of which may affect contiguous cells, nearby groups of cells, or distant cells, thus functioning as local or systemic hormones. The name is an acronym for amine precursor uptake and decarboxylation cell."], "t": []}, {"i": "UMLS:C0003649", "l": "APUD Cells", "d": [], "t": []}, {"i": "NCIT:C12655", "l": "APUD Cell", "d": ["An endocrine cell that has the capabilities of amine precursor uptake and decarboxylation, and low molecular weight polypeptide hormone secretion."], "t": []}, {"i": "MESH:D001078", "l": "APUD Cells", "d": [], "t": []}], "preferred_name": "amine precursor uptake and decarboxylation cell", "taxa": []}
{"type": "biolink:Cell", "ic": 90.871710685482, "identifiers": [{"i": "UMLS:C1709102", "l": "Myopericyte", "d": [], "t": []}, {"i": "NCIT:C51141", "l": "Myopericyte", "d": [], "t": []}], "preferred_name": "Myopericyte", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C4688385", "l": "Rocapuldencel-T", "d": [], "t": []}, {"i": "NCIT:C77907", "l": "Rocapuldencel-T", "d": ["A cancer vaccine in which autologous dendritic cells are transfected with patient-specific renal cell carcinoma (RCC) RNA and a synthetic, truncated human CD40 ligand (CD40L) RNA with potential immunostimulatory and antineoplastic activities. Individual RCC-specific RNA, encoding a unique repertoire of tumor-associated antigens (TAAs) (including telomerase reverse transcriptase, G250, and oncofetal antigen) is electroporated into autologous dendritic cells (DCs), transfected with synthetic RNA that encodes a truncated version of the T-cell protein CD40L; the transfected autologous DCs express and process both patient-specific RCC TAAs and the truncated CD40L protein. When reintroduced back to the patient, rocapuldencel-T may elicit a highly specific cytotoxic T-cell (CTL) response against RCC cells expressing the patient-specific RCC TAA repertoire. The signal cascade initiated by stimulation of the truncated, ectopically expressed co-stimulatory molecule CD40L results in the secretion of the inflammatory cytokine IL-12 downstream."], "t": []}], "preferred_name": "Rocapuldencel-T", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5427571", "l": "Cones.right", "d": [], "t": []}], "preferred_name": "Cones.right", "taxa": []}
{"type": "biolink:Cell", "ic": 78.05853671694304, "identifiers": [{"i": "CL:0000541", "l": "melanoblast", "d": ["A cell that originates from the neural crest and differentiates into a pigment cell."], "t": []}, {"i": "UMLS:C0598170", "l": "Melanoblast", "d": [], "t": []}, {"i": "NCIT:C85503", "l": "Melanoblast", "d": ["An immature precursor cell that gives rise to a melanocyte."], "t": []}], "preferred_name": "melanoblast", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0882894", "l": "CD5+CD20+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:1373038001", "l": "", "d": [], "t": []}], "preferred_name": "CD5+CD20+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": 89.40238429118027, "identifiers": [{"i": "CL:1001503", "l": "olfactory bulb tufted cell", "d": ["The principal glutaminergic neuron located in the outer third of the external plexiform layer of the olfactory bulb; a single short primary dendrite traverses the outer external plexiform layer and terminates within an olfactory glomerulus in a tuft of branches, where it receives the input from olfactory receptor neuron axon terminals; axons of the tufted cells transfer information to a number of areas in the brain, including the piriform cortex, entorhinal cortex, olfactory tubercle, and amygdala."], "t": []}], "preferred_name": "olfactory bulb tufted cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4707434", "l": "Technetium (99m-Tc) exametazime labeled leukocytes", "d": [], "t": []}, {"i": "SNOMEDCT:765339002", "l": "", "d": [], "t": []}], "preferred_name": "Technetium (99m-Tc) exametazime labeled leukocytes", "taxa": []}
{"type": "biolink:Cell", "ic": 81.743421370964, "identifiers": [{"i": "CL:0010017", "l": "zygote", "d": ["A zygote in a plant or an animal."], "t": []}], "preferred_name": "zygote", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1440261", "l": "Cell negative for CD16 antigen and positive for CD34 antigen", "d": [], "t": []}, {"i": "SNOMEDCT:1373166007", "l": "", "d": [], "t": []}], "preferred_name": "Cell negative for CD16 antigen and positive for CD34 antigen", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5418067", "l": "PHE885", "d": [], "t": []}, {"i": "NCIT:C174124", "l": "Autologous Anti-BCMA CAR T-cells PHE885", "d": ["A preparation of autologous T-lymphocytes that have been genetically engineered to express a chimeric antigen receptor (CAR) targeting the human tumor-associated antigen (TAA) B-cell maturation antigen (BCMA; tumor necrosis factor receptor superfamily member 17; TNFRSF17), with potential antineoplastic activity. Upon administration, the autologous anti-BCMA CAR T-cells PHE885 recognize and induce selective toxicity against BCMA-expressing tumor cells. BCMA, a tumor-specific antigen and a receptor for both a proliferation-inducing ligand (APRIL) and B-cell activating factor (BAFF), is a member of the tumor necrosis factor receptor superfamily (TNFRSF) and plays a key role in plasma cell survival. BCMA is found on the surfaces of plasma cells and is overexpressed on malignant plasma cells."], "t": []}], "preferred_name": "PHE885", "taxa": []}
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{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0333766", "l": "Moth-eaten fibers", "d": [], "t": []}, {"i": "SNOMEDCT:53408006", "l": "", "d": [], "t": []}], "preferred_name": "Moth-eaten fibers", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1257739", "l": "NIH 3T3 Cells", "d": [], "t": []}, {"i": "NCIT:C17422", "l": "NIH/3T3", "d": ["An immortalized fibroblast cell line derived from a mouse embryo in 1962 by George Todaro and Howard Green. These cells retain contact inhibition."], "t": []}, {"i": "MESH:D041681", "l": "NIH 3T3 Cells", "d": [], "t": []}], "preferred_name": "NIH 3T3 Cells", "taxa": []}
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{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5555589", "l": "Autologous Anti-ALPP CAR Retroviral Vector-transduced T Cells", "d": [], "t": []}, {"i": "NCIT:C179291", "l": "Autologous Anti-ALPP CAR Retroviral Vector-transduced T Cells", "d": ["A preparation of autologous T lymphocytes that have been transduced with a retroviral vector expressing a chimeric antigen receptor (CAR) targeting alkaline phosphatase, placental type (ALPP; placental alkaline phosphatase; PLAP), with potential immunostimulating and antineoplastic activities. Upon infusion back into the patient, autologous anti-ALPP CAR retroviral vector-transduced T cells target and bind to ALPP-expressing tumor cells, thereby inducing selective toxicity in ALPP-expressing tumor cells. ALPP, mainly expressed in placenta and testis, is overexpressed on certain tumor cell types, such as on a proportion of colorectal cancers while not expressed in any other normal tissues. It plays a key role in tumor cell proliferation."], "t": []}], "preferred_name": "Autologous Anti-ALPP CAR Retroviral Vector-transduced T Cells", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5220616", "l": "Transitional cells|Urine/Urine sed", "d": [], "t": []}], "preferred_name": "Transitional cells|Urine/Urine sed", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1879680", "l": "remestemcel-L", "d": [], "t": []}, {"i": "MESH:C000711674", "l": "remestemcel-l", "d": [], "t": []}], "preferred_name": "remestemcel-L", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5172509", "l": "Mesothelial cells | Vitreous fluid | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Mesothelial cells | Vitreous fluid | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5853524", "l": "Allogeneic Vδ1+ γδ T cells", "d": [], "t": []}], "preferred_name": "Allogeneic Vδ1+ γδ T cells", "taxa": []}
{"type": "biolink:Cell", "ic": 89.40238429118027, "identifiers": [{"i": "CL:4052060", "l": "spinous cell", "d": ["A differentiating keratinocyte found in the epidermis and oral epithelium, located in the stratum spinosum, characterized by a spiny appearance due to abundant intercellular desmosomal junctions."], "t": []}], "preferred_name": "spinous cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5706499", "l": "Trained Immunity Natural Killer Cells IBR900", "d": [], "t": []}, {"i": "NCIT:C188374", "l": "Trained Immunity Natural Killer Cells IBR900", "d": ["A preparation of trained immunity natural killer (tiNK) cells, with potential cytolytic and antineoplastic activities. Upon administration, tiNK cells IBR900 recognize and lyse cancer cells. These cells also secrete pro-inflammatory cytokines, which further stimulate an anti-tumor immune response."], "t": []}], "preferred_name": "Trained Immunity Natural Killer Cells IBR900", "taxa": []}
{"type": "biolink:Cell", "ic": 86.30756602822301, "identifiers": [{"i": "UMLS:C1514831", "l": "Reliance ES Cell Line", "d": [], "t": []}, {"i": "NCIT:C20287", "l": "Reliance ES Cell Line", "d": [], "t": []}], "preferred_name": "Reliance ES Cell Line", "taxa": []}
{"type": "biolink:Cell", "ic": 82.16838616155795, "identifiers": [{"i": "CL:0002437", "l": "mature CD8 single-positive thymocyte", "d": ["A mature CD8-positive, CD4-negative alpha-beta T cell found in the thymus that is CD24-low and has high expression of the T cell receptor."], "t": []}], "preferred_name": "mature CD8 single-positive thymocyte", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0524977", "l": "Intestinal L Cells", "d": [], "t": []}], "preferred_name": "Intestinal L Cells", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5551406", "l": "relmacabtagene autoleucel", "d": [], "t": []}, {"i": "MESH:C000718412", "l": "relmacabtagene autoleucel", "d": [], "t": []}], "preferred_name": "relmacabtagene autoleucel", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5667089", "l": "Allogeneic MUC1-C-specific CAR-T Cells P-MUC1C-ALLO1", "d": [], "t": []}, {"i": "NCIT:C187029", "l": "Allogeneic MUC1-C-specific CAR-T Cells P-MUC1C-ALLO1", "d": ["An off-the-shelf (OTS) preparation of human allogeneic T-lymphocytes containing primarily stem cell memory T-cells (Tscm) that have been genetically modified to express a chimeric antigen receptor (CAR) specific for the C-terminal subunit of the tumor-associated antigen (TAA) mucin-1 (MUC1-C) and gene-edited to knockout both the T-cell receptor (TCR) and major histocompatibility complex (MHC) class I proteins, with potential immunostimulating and antineoplastic activities. Upon administration, allogeneic MUC1-C-specific CAR-T cells P-MUC1C-ALLO1 specifically recognize and induce selective toxicity in MUC1-C-expressing tumor cells. MUC1, a glycoprotein normally expressed on epithelial cells and overexpressed on the surface of a variety of cancer cells, plays a key role in tumor cell survival and proliferation. The proteolytic cleavage of MUC1 in the tumor microenvironment (TME) leads to the overexpression of MUC1-C in the TME."], "t": []}], "preferred_name": "Allogeneic MUC1-C-specific CAR-T Cells P-MUC1C-ALLO1", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:1000457", "l": "mesothelial cell of visceral peritoneum", "d": ["A mesothelial cell that is part of the visceral peritoneum."], "t": []}], "preferred_name": "mesothelial cell of visceral peritoneum", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:1001430", "l": "urethra urothelial cell", "d": ["A urothelial cell that is part of the urethra urothelium. This cell plays a crucial role in maintaining the urethral barrier function, protecting against toxic substances in urine, sensing environmental changes, and defending against pathogen entry."], "t": []}], "preferred_name": "urethra urothelial cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0003012", "l": "G9 retinal ganglion cell", "d": ["A mono-stratified retinal ganglion cell that has a large dendritic field and a medium dendritic arbor with post synaptic terminals in sublaminar layer S1 and S2."], "t": []}], "preferred_name": "G9 retinal ganglion cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5157344", "l": "CD19 blasts | XXX | Cell markers", "d": [], "t": []}], "preferred_name": "CD19 blasts | XXX | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "CL:0011030", "l": "dermal microvascular endothelial cell", "d": ["Any microvascular endothelial cell that is part of the dermis."], "t": []}], "preferred_name": "dermal microvascular endothelial cell", "taxa": []}
{"type": "biolink:Cell", "ic": 89.40238429118027, "identifiers": [{"i": "UMLS:C1709209", "l": "Neoplastic Thyroid Gland Follicular Signet Ring Cell", "d": [], "t": []}, {"i": "NCIT:C47831", "l": "Neoplastic Thyroid Gland Follicular Signet Ring Cell", "d": ["A neoplastic thyroid gland follicular cell with cytoplasmic vacuole and eccentrically placed nucleus."], "t": []}], "preferred_name": "Neoplastic Thyroid Gland Follicular Signet Ring Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5785777", "l": "Allogeneic Anti-CD20/CD22 Universal CAR-expressing T-lymphocytes UCART20x22", "d": [], "t": []}, {"i": "NCIT:C193468", "l": "Allogeneic Anti-CD20/CD22 Universal CAR-expressing T-lymphocytes UCART20x22", "d": ["A preparation of allogeneic, off-the-shelf (OTS), universal transcription activator-like effector nuclease (TALEN)-engineered T-lymphocytes that have been genetically modified to express chimeric antigen receptors (CARs) specific for the tumor-associated antigens (TAAs) cluster of differentiation 20 (CD20) and CD22, with potential immunostimulating and antineoplastic activities. Using TALEN technology, the T-cell receptor (TCR) alpha chain (TRAC) and CD52 genes are inactivated. Upon administration, the allogeneic anti-CD20/CD22 universal CAR-expressing T-lymphocytes UCART20x22 specifically recognize and induce selective toxicity in CD20- and CD22-expressing tumor cells. CD20 and CD22 are overexpressed in certain hematologic malignancies. Inactivation of the CD52 gene makes the CAR-T cells UCART20x22 resistant to anti-CD52 monoclonal antibody treatment that is used during preconditioning regimen to enhance the expansion and persistence of the CAR-T cells. The knockout of TRAC eliminates TCR expression and is intended to abrogate the potential induction of graft-versus-host disease (GvHD) by the CAR-T cells."], "t": []}], "preferred_name": "Allogeneic Anti-CD20/CD22 Universal CAR-expressing T-lymphocytes UCART20x22", "taxa": []}
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{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C0162556", "l": "Suppressor inducer T lymphocyte", "d": [], "t": []}, {"i": "NCIT:C12541", "l": "Suppressor-Inducer T-Lymphocyte", "d": ["A subtype of CD4+ T lymphocyte that triggers CD8+ T lymphocytes to inhibit the production of antibodies."], "t": []}], "preferred_name": "Suppressor inducer T lymphocyte", "taxa": []}
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{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0003047", "l": "M14 retinal ganglion cell", "d": ["A bistratifed retinal ganglion cell that has small, symmetric dendritic fields that terminate in S1 and S4-S5."], "t": []}], "preferred_name": "M14 retinal ganglion cell", "taxa": []}
{"type": "biolink:Cell", "ic": 52.24762615096506, "identifiers": [{"i": "CL:0000150", "l": "glandular secretory epithelial cell", "d": ["An epithelial cell, located in a gland, that is specialised for the synthesis and secretion of specific biomolecules, such as hormones, or mucous."], "t": []}, {"i": "UMLS:C1517548", "l": "Glandular cell", "d": [], "t": []}, {"i": "NCIT:C33923", "l": "Glandular Cell", "d": ["An epithelial cell which may release secretions to a free epithelial surface (exocrine) or to the circulatory system (endocrine)."], "t": []}], "preferred_name": "glandular secretory epithelial cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4033062", "l": "interstitial extravillous trophoblast cell", "d": ["A trophoblast cell that invades the uterine wall to anchor the placenta to the uterus. An interstitial extravillous trophoblast cell differentiates from an extravillous trophoblast cell, becoming hyperchromatic and changing its morphology to a fibroblast-like spindle-shaped cell. In humans, this cell can be distinguished by the expression of placental-specific protein 8, which stimulates migration."], "t": []}], "preferred_name": "interstitial extravillous trophoblast cell", "taxa": []}
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{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1267982", "l": "Lymphocyte positive for CD95 antigen", "d": [], "t": []}, {"i": "SNOMEDCT:117422005", "l": "", "d": [], "t": []}], "preferred_name": "Lymphocyte positive for CD95 antigen", "taxa": []}
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{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0004245", "l": "indoleamine-accumulating amacrine cell", "d": ["An amacrine cell with a wide dendritic field and post-synaptic terminals in S5. This cell type releases the neurotransmitters gamma-aminobutyric acid (GABA) and serotonin."], "t": []}], "preferred_name": "indoleamine-accumulating amacrine cell", "taxa": []}
{"type": "biolink:Cell", "ic": 88.20185721311867, "identifiers": [{"i": "UMLS:C1514165", "l": "Pleomorphic Adenocarcinoma Cell", "d": [], "t": []}, {"i": "NCIT:C37171", "l": "Pleomorphic Adenocarcinoma Cell", "d": [], "t": []}], "preferred_name": "Pleomorphic Adenocarcinoma Cell", "taxa": []}
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{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0483190", "l": "CD34+DR+", "d": [], "t": []}], "preferred_name": "CD34+DR+", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1520211", "l": "Yolk Cell", "d": [], "t": []}, {"i": "NCIT:C33933", "l": "Yolk Cell", "d": ["A cell that splits off from the inner cell mass of the blastocyst and becomes part of the primitive yolk sac, which in non-mammals nourishes the embryo during development."], "t": []}], "preferred_name": "Yolk Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5854512", "l": "Autologous Anti-mesothelin CAR-T Cells UCLM802", "d": [], "t": []}, {"i": "NCIT:C200297", "l": "Autologous Anti-mesothelin CAR-T Cells UCLM802", "d": ["A preparation of autologous T-lymphocytes that have been genetically modified to express a chimeric antigen receptor (CAR) specific for the human tumor-associated antigen (TAA) mesothelin (MSLN), with potential immunomodulating and antineoplastic activities. Upon administration, the autologous anti-MSLN CAR-T cells UCLM802 specifically target and kill MSLN-expressing tumor cells. Mesothelin, a cell surface glycoprotein involved in cell adhesion, is overexpressed in a variety of cancer cell types."], "t": []}], "preferred_name": "Autologous Anti-mesothelin CAR-T Cells UCLM802", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4307083", "l": "hypendemal cell (Mmus)", "d": ["A hypendymal cell of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Sspo (Mmus), Wfdc2 (Mmus). It is distinguished from other Astro-Epen cells by expression of Sspo, Wfdc2. These cells are located in the Midbrain, brain , in or close to the regions: third ventricle, posterior commissure, Subcommissural organ . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5263 Hypendymal NN_1."], "t": []}], "preferred_name": "hypendemal cell (Mmus)", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0000683", "l": "ependymoglial cell", "d": ["A cell that transports hormones from neurosecretory cells. This nerve cell is characterized by bipolar shape and endfeet that contact a basal lamina around blood vessels, and/or the pia mater or vitreous body of the eye and additionally contact the ventricular surface or sub-retinal space."], "t": []}, {"i": "UMLS:C0596979", "l": "Muller Cells", "d": [], "t": []}], "preferred_name": "ependymoglial cell", "taxa": []}
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{"type": "biolink:Cell", "ic": 75.08236434612573, "identifiers": [{"i": "UMLS:C1522104", "l": "Spindle Melanoma Cell", "d": [], "t": []}, {"i": "NCIT:C36874", "l": "Spindle Melanoma Cell", "d": [], "t": []}], "preferred_name": "Spindle Melanoma Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 90.871710685482, "identifiers": [{"i": "UMLS:C1519442", "l": "Specialized epithelial cell", "d": [], "t": []}, {"i": "NCIT:C13006", "l": "Specialized Epithelial Cell", "d": ["A cell that covers the surface of the body and lines its cavities that has a specific function to perform."], "t": []}], "preferred_name": "Specialized epithelial cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C2323503", "l": "Set of leukocytes", "d": [], "t": []}], "preferred_name": "Set of leukocytes", "taxa": []}
{"type": "biolink:Cell", "ic": 92.76600187037766, "identifiers": [{"i": "UMLS:C1518243", "l": "Malignant Small Undifferentiated Cell", "d": [], "t": []}, {"i": "NCIT:C36944", "l": "Malignant Small Undifferentiated Cell", "d": [], "t": []}], "preferred_name": "Malignant Small Undifferentiated Cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5833061", "l": "CD65+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:1372920008", "l": "", "d": [], "t": []}], "preferred_name": "CD65+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0229643", "l": "Eosinophilic metamyelocyte", "d": [], "t": []}, {"i": "SNOMEDCT:80036001", "l": "", "d": [], "t": []}], "preferred_name": "Eosinophilic metamyelocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 90.871710685482, "identifiers": [{"i": "CL:0007006", "l": "chordamesodermal cell", "d": ["Mesodermal cell that is axially located and gives rise to the cells of the notochord."], "t": []}], "preferred_name": "chordamesodermal cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1254550", "l": "Toxicopathic Erythrocyte", "d": [], "t": []}], "preferred_name": "Toxicopathic Erythrocyte", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C2350245", "l": "Megakaryocyte Progenitor Cells", "d": [], "t": []}, {"i": "MESH:D055016", "l": "Megakaryocyte Progenitor Cells", "d": [], "t": []}], "preferred_name": "Megakaryocyte Progenitor Cells", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5960014", "l": "Allogeneic Hypoimmune Anti-CD22 CAR T-cells SC262", "d": [], "t": []}, {"i": "NCIT:C206707", "l": "Allogeneic Hypoimmune Anti-CD22 CAR T-cells SC262", "d": ["A preparation of human allogeneic CD4+ and CD8+ T-lymphocytes transduced with a chimeric antigen receptor (CAR) specific for the tumor-associated antigen (TAA) CD22, and ex vivo modified to disrupt the expression of major histocompatibility (MHC) class I and MHC class II molecules and to express CD47, with potential immunomodulating and antineoplastic activities. Upon introduction into the patient, the allogeneic hypoimmune anti-CD22 CAR T-cells SC262 recognize and bind to CD22-expressing tumor cells. This may result in a specific cytotoxic T-lymphocyte (CTL)-mediated killing of CD22-positive tumor cells. CD22, a B-lineage-restricted, transmembrane phosphoglycoprotein, is expressed on malignant B-cells. The disruption of MHC class I and MHC class II molecules and the expression of CD47 prevent both innate and adaptive immune responses against the allogeneic CAR T-cells, thereby increasing the persistence of the CAR T-cells."], "t": []}], "preferred_name": "Allogeneic Hypoimmune Anti-CD22 CAR T-cells SC262", "taxa": []}
{"type": "biolink:Cell", "ic": 85.53200374075534, "identifiers": [{"i": "CL:0000820", "l": "B-1a B cell", "d": ["A B-1 B cell that has the phenotype CD5-positive."], "t": []}], "preferred_name": "B-1a B cell", "taxa": []}
{"type": "biolink:Cell", "ic": 79.07356789860069, "identifiers": [{"i": "UMLS:C1882046", "l": "Neoplastic Eccrine Cell", "d": [], "t": []}, {"i": "NCIT:C62495", "l": "Neoplastic Eccrine Cell", "d": [], "t": []}], "preferred_name": "Neoplastic Eccrine Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "UMLS:C1518368", "l": "Non-Keratinizing Malignant Small Squamous Cell", "d": [], "t": []}, {"i": "NCIT:C36790", "l": "Non-Keratinizing Malignant Small Squamous Cell", "d": [], "t": []}], "preferred_name": "Non-Keratinizing Malignant Small Squamous Cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0684128", "l": "lymphoid megakaryocyte", "d": [], "t": []}], "preferred_name": "lymphoid megakaryocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0003004", "l": "G3 retinal ganglion cell", "d": ["A bistratified retinal ganglion cell that has a small dendritic field with sparse density that terminates at the intersection of the S4-S5 sublaminar level, and a second dendrite field that is medium in size and degree of arborization that terminates in sublaminar layer S2."], "t": []}], "preferred_name": "G3 retinal ganglion cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1511119", "l": "Binucleated Reed-Sternberg Cell", "d": [], "t": []}, {"i": "NCIT:C37022", "l": "Binucleated Reed-Sternberg Cell", "d": [], "t": []}], "preferred_name": "Binucleated Reed-Sternberg Cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1979666", "l": "CD19+CD58+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:1372985000", "l": "", "d": [], "t": []}], "preferred_name": "CD19+CD58+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:1000417", "l": "myoepithelial cell of sweat gland", "d": ["A myoepithelial cell that is part of the sweat gland."], "t": []}, {"i": "UMLS:C1180270", "l": "Myoepithelial cell of sweat gland", "d": [], "t": []}], "preferred_name": "myoepithelial cell of sweat gland", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4700206", "l": "CD25+CD45RA+CD127low cell", "d": [], "t": []}, {"i": "SNOMEDCT:1373301008", "l": "", "d": [], "t": []}], "preferred_name": "CD25+CD45RA+CD127low cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C2334601", "l": "Intermediate cell of urothelium", "d": [], "t": []}], "preferred_name": "Intermediate cell of urothelium", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5157614", "l": "CD55+CD59 cells | Blood | Cell markers", "d": [], "t": []}], "preferred_name": "CD55+CD59 cells | Blood | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1514046", "l": "Neoplastic Neuroendocrine Polygonal Cell with Cytoplasmic Eosinophilic Globules", "d": [], "t": []}, {"i": "NCIT:C36934", "l": "Neoplastic Neuroendocrine Polygonal Cell with Cytoplasmic Eosinophilic Globules", "d": [], "t": []}], "preferred_name": "Neoplastic Neuroendocrine Polygonal Cell with Cytoplasmic Eosinophilic Globules", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1518990", "l": "Periosteal cell", "d": [], "t": []}, {"i": "NCIT:C33305", "l": "Periosteal Cell", "d": ["A cell of the loose cellular inner layer of the periosteal tissue in the intramembranous ossification of bone"], "t": []}], "preferred_name": "Periosteal cell", "taxa": []}
{"type": "biolink:Cell", "ic": 84.83823963392128, "identifiers": [{"i": "CL:0003001", "l": "bistratified retinal ganglion cell", "d": ["A retinal ganglion cell that has dendrites stratified in two layers of the inner-plexiform layer."], "t": []}], "preferred_name": "bistratified retinal ganglion cell", "taxa": []}
{"type": "biolink:Cell", "ic": 92.76600187037766, "identifiers": [{"i": "CL:0020011", "l": "hair follicle associated fibroblast", "d": ["A specialized dermal fibroblast within the hair follicle mesenchymal compartment that participates in epithelial-mesenchymal signaling to regulate hair morphogenesis, cycling, and homeostasis through production of inductive signals and extracellular matrix maintenance."], "t": []}], "preferred_name": "hair follicle associated fibroblast", "taxa": []}
{"type": "biolink:Cell", "ic": 88.20185721311867, "identifiers": [{"i": "CL:0019032", "l": "intestinal tuft cell", "d": ["A tuft cell that is part of the intestinal epithelium, characterized by a distinctive apical tuft and lateral cytospinules connecting to neighbouring cells. This cell senses luminal stimuli via taste receptors and succinate signalling, initiating type 2 immune responses through the secretion of interleukin-25 while modulating epithelial regeneration through prostaglandin synthesis. It expresses key molecular markers such as doublecortin-like kinase 1 (DCLK1) in mice (Hendel et al., 2022), and KIT proto-oncogene in humans (Huang et al., 2024). Developed from intestinal crypt stem cells, this cell requires transcription factor POU2F3 for its development."], "t": []}], "preferred_name": "intestinal tuft cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5216287", "l": "Neutrophils.hypersegmented|NCnc|Pt|Bld", "d": [], "t": []}], "preferred_name": "Neutrophils.hypersegmented|NCnc|Pt|Bld", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C2324943", "l": "Delayed type hypersensitivity-related T lymphocyte", "d": [], "t": []}], "preferred_name": "Delayed type hypersensitivity-related T lymphocyte", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5171675", "l": "Lymphocytes Immunoblastic | Blood | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Lymphocytes Immunoblastic | Blood | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:2000083", "l": "hair follicle dermal papilla cell of scalp", "d": ["Any hair follicle dermal papilla cell that is part of a scalp."], "t": []}], "preferred_name": "hair follicle dermal papilla cell of scalp", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C3652653", "l": "indium (111In) oxinate labelled cells", "d": [], "t": []}], "preferred_name": "indium (111In) oxinate labelled cells", "taxa": []}
{"type": "biolink:Cell", "ic": 92.76600187037766, "identifiers": [{"i": "CL:2000034", "l": "anterior lateral line neuromast hair cell", "d": ["Any neuromast hair cell that is part of a anterior lateral line."], "t": []}], "preferred_name": "anterior lateral line neuromast hair cell", "taxa": []}
{"type": "biolink:Cell", "ic": 92.76600187037766, "identifiers": [{"i": "CL:0002350", "l": "endocardial cell", "d": ["An endothelial cell that lines the intracavitary lumen of the heart, separating the circulating blood from the underlying myocardium. This cell type releases a number of vasoactive substances including prostacyclin, nitrous oxide and endothelin."], "t": []}, {"i": "UMLS:C1184810", "l": "Endocardial cell", "d": [], "t": []}], "preferred_name": "endocardial cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:2000018", "l": "endothelial cell of coronary artery", "d": ["Any endothelial cell of artery that is part of a coronary artery."], "t": []}], "preferred_name": "endothelial cell of coronary artery", "taxa": []}
{"type": "biolink:Cell", "ic": 76.9766555310214, "identifiers": [{"i": "UMLS:C1518221", "l": "Malignant Neuroendocrine Polygonal Cell", "d": [], "t": []}, {"i": "NCIT:C36855", "l": "Malignant Neuroendocrine Polygonal Cell", "d": [], "t": []}], "preferred_name": "Malignant Neuroendocrine Polygonal Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0004243", "l": "WF3-2 amacrine cell", "d": ["An amacrine cell with a wild dendritic field, dendrites in S3, and post-synaptic terminals in S3. Dendrites have spikes, cross over each other, and cover a larger volume than dendrties of W3-1 retinal amacrine cells."], "t": []}], "preferred_name": "WF3-2 amacrine cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5667077", "l": "Anti-B7-H3 CAR T Cells TAA06", "d": [], "t": []}, {"i": "NCIT:C186668", "l": "Anti-B7-H3 CAR T Cells TAA06", "d": ["A preparation of T-lymphocytes that have been genetically modified to express a chimeric antigen receptor (CAR) targeting the immunoregulatory protein B7-homologue 3 (B7-H3, CD276), with potential immunostimulating and antineoplastic activities. Upon administration, anti-B7-H3 CAR T-cells TAA06 target and bind to B7-H3-expressing tumor cells, thereby inducing selective toxicity in B7-H3-expressing tumor cells. B7-H3, a type I transmembrane protein and a member of the B7 co-stimulatory protein superfamily, is overexpressed on certain tumor cell types and on various immune cells. It is a negative regulator of T-cell activation and its overexpression plays a key role in tumor cell invasion and metastasis."], "t": []}], "preferred_name": "Anti-B7-H3 CAR T Cells TAA06", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0002660", "l": "luminal cell of acinus of lactiferous gland", "d": ["A luminal epithelial cell of mammary gland located in acinus of structure."], "t": []}, {"i": "UMLS:C1184143", "l": "Luminal cell of acinus of lactiferous gland", "d": [], "t": []}], "preferred_name": "luminal cell of acinus of lactiferous gland", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1440263", "l": "CD17+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:1372857003", "l": "", "d": [], "t": []}], "preferred_name": "CD17+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C2328196", "l": "Sympathetic preganglionic neuron", "d": [], "t": []}], "preferred_name": "Sympathetic preganglionic neuron", "taxa": []}
{"type": "biolink:Cell", "ic": 76.22330125402472, "identifiers": [{"i": "CL:0002490", "l": "organ of Corti supporting cell", "d": ["A supporting cell of the organ of Corti."], "t": []}], "preferred_name": "organ of Corti supporting cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5166081", "l": "Granulocytes | Cerebral spinal fluid | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Granulocytes | Cerebral spinal fluid | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5447312", "l": "Autologous Tolerogenic Proinsulin Peptide-loaded Dendritic Cells PIpepTolDC", "d": [], "t": []}, {"i": "NCIT:C176573", "l": "Autologous Tolerogenic Proinsulin Peptide-loaded Dendritic Cells PIpepTolDC", "d": ["A vaccine composed of autologous tolerogenic dendritic cells (DCs) loaded with the beta cell protein proinsulin peptide (PIpep), C19-A3, with potential immunosuppressive and immune-regulating activities. Upon intradermal administration, the autologous tolerogenic PIpep-loaded DCs may induce proinsulin-specific regulatory T-cells (Tregs). This may suppress the autoimmune destruction of the insulin-producing beta cells, thereby protecting the beta cells."], "t": []}], "preferred_name": "Autologous Tolerogenic Proinsulin Peptide-loaded Dendritic Cells PIpepTolDC", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5962155", "l": "Anti-FOLR1 CAR T-cells", "d": [], "t": []}, {"i": "NCIT:C209362", "l": "Anti-FOLR1 CAR T-cells", "d": ["A preparation of T-lymphocytes that have been engineered to express a chimeric antigen receptor (CAR) specific for folate receptor alpha (FolRa; FOLR1), with potential immunostimulating and antineoplastic activities. Upon administration, anti-FOLR1 CAR T-cells specifically recognize and bind to FOLR1-expressing tumor cells, resulting in specific T-cell-mediated tumor cell lysis. FOLR1 is a glycosylphosphatidylinositol linked cell surface glycoprotein that is widely expressed in certain cancers while its expression is limited in normal tissues."], "t": []}], "preferred_name": "Anti-FOLR1 CAR T-cells", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1522374", "l": "Mouse Langerhans Cell", "d": [], "t": []}, {"i": "NCIT:C24191", "l": "Mouse Langerhans Cell", "d": [], "t": []}], "preferred_name": "Mouse Langerhans Cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5157551", "l": "CD4+CD45RO+ cells | Body fluid | Cell markers", "d": [], "t": []}], "preferred_name": "CD4+CD45RO+ cells | Body fluid | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5206468", "l": "Autologous Anti-HLA-A*02/AFP TCRm-expressing T-cells ET140202", "d": [], "t": []}, {"i": "NCIT:C162260", "l": "Autologous Anti-HLA-A*02/AFP TCRm-expressing T-cells ET140202", "d": ["A preparation of autologous T-lymphocytes that have been transduced with a lentiviral vector to express a T-cell receptor mimetic (TCRm) antibody synthesized by a proprietary phage display platform, targeting the immunogenetic human tumor-associated antigen (TAA) alpha-fetoprotein (AFP) complexed with human leukocyte antigen (HLA)-A*02 (HLA-A*02/AFP), with potential antineoplastic and immunomodulatory activities. Upon administration, the autologous anti-HLA-A*02/AFP TCRm-expressing T-cells ET140202 specifically recognize and selectively bind to AFP peptides presented by HLA-A*02. This results in cytotoxic T-lymphocyte (CTL)-mediated elimination of AFP-expressing tumor cells. AFP, an intracellularly expressed fetal glycoprotein rarely expressed in adult tissues, is overexpressed in certain tumors of endodermal origin and plays a key role in tumor cell proliferation and survival. AFP is processed into peptides and presented by class I major histocompatibility complexes (MHCs) on the surface of tumor cells."], "t": []}], "preferred_name": "Autologous Anti-HLA-A*02/AFP TCRm-expressing T-cells ET140202", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0002226", "l": "non-nucleated secondary lens fiber", "d": ["A secondary lens fiber cell that lacks a nucleus."], "t": []}, {"i": "UMLS:C1180090", "l": "Non-nucleated lens fiber", "d": [], "t": []}], "preferred_name": "non-nucleated secondary lens fiber", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "UMLS:C1514740", "l": "Reactive Plasma Cell", "d": [], "t": []}, {"i": "NCIT:C40563", "l": "Reactive Plasma Cell", "d": [], "t": []}], "preferred_name": "Reactive Plasma Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 65.73333920513937, "identifiers": [{"i": "UMLS:C1514003", "l": "Neoplastic Large Germ Cell", "d": [], "t": []}, {"i": "NCIT:C36904", "l": "Neoplastic Large Germ Cell", "d": [], "t": []}], "preferred_name": "Neoplastic Large Germ Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5909648", "l": "Autologous KRAS Mutant-specific TCRs Gene Engineered PBLs", "d": [], "t": []}, {"i": "NCIT:C204252", "l": "Autologous KRAS Mutant-specific TCRs Gene Engineered PBLs", "d": ["A preparation of autologous peripheral blood lymphocytes (PBLs) that have been genetically modified to express T-cell receptors (TCRs) specific for K-RAS (KRAS) mutations, with potential immunomodulating and antineoplastic activities. Upon isolation, transduction, expansion ex vivo and re-introduction into the patient, the autologous KRAS mutant-specific TCRs gene engineered PBLs target and bind to KRAS mutants-expressing tumor cells, resulting in a cytotoxic T-lymphocyte (CTL)-mediated killing of KRAS mutants-expressing tumor cells. KRAS, a member of the RAS family of oncogenes, serves an important role in cell signaling, division and differentiation. Mutations of KRAS may induce constitutive signal transduction leading to tumor cell proliferation, invasion, and metastasis."], "t": []}], "preferred_name": "Autologous KRAS Mutant-specific TCRs Gene Engineered PBLs", "taxa": []}
{"type": "biolink:Cell", "ic": 92.76600187037766, "identifiers": [{"i": "CL:4301596", "l": "Astro-OLF NN_1 astrocyte (Mmus)", "d": ["A astrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Aqp4 (Mmus), Prss23 (Mmus), Igfbp2 (Mmus). Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Supertype:1166 Astro-OLF NN_1."], "t": []}], "preferred_name": "Astro-OLF NN_1 astrocyte (Mmus)", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4518146", "l": "Population of all spermatozoa with double forms in portion of fluid", "d": [], "t": []}, {"i": "SNOMEDCT:725251004", "l": "", "d": [], "t": []}], "preferred_name": "Population of all spermatozoa with double forms in portion of fluid", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5163725", "l": "Erythrocytes | Seminal plasma | Fertility testing", "d": [], "t": []}], "preferred_name": "Erythrocytes | Seminal plasma | Fertility testing", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5454454", "l": "Epithelial cells | Cervix or Vagina | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Epithelial cells | Cervix or Vagina | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4052055", "l": "mature NK T cell, human", "d": ["A mature NK T cell that can be identified by the expression of CD56 in humans."], "t": []}], "preferred_name": "mature NK T cell, human", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4033036", "l": "OFFx cell", "d": ["An OFF bipolar cell that is fovea-specific and expresses FEZF1, NXPH1 and NXPH2."], "t": []}], "preferred_name": "OFFx cell", "taxa": []}
{"type": "biolink:Cell", "ic": 90.871710685482, "identifiers": [{"i": "CL:0002493", "l": "strial basal cell", "d": ["A polarized cell that is juxtaposed to fibrocytes in the underlying spiral ligament. This cell type secretes potassium ions derived from fibrocytes through gap junctions."], "t": []}], "preferred_name": "strial basal cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C3829297", "l": "Lenti-D/ABCD1-transduced Autologous Hematopoietic Stem Cells", "d": [], "t": []}, {"i": "NCIT:C111902", "l": "Lenti-D/ABCD1-transduced Autologous Hematopoietic Stem Cells", "d": ["Autologous CD34+ hematopoietic stem cells transduced with Lenti-D lentiviral vector encoding the human ATP-binding cassette, sub-family D, member 1 (ABCD1) cDNA, for the potential treatment of childhood cerebral adrenoleukodystrophy (CCALD). Upon administration of the lenti-D/ABCD1-transduced autologous hematopoietic stem cells, the cells proliferate, and some travel to the brain and differentiate into microglial cells. The expressed ABCD1 restores the function of ALD protein (ALDP) and aids in the treatment of CCALD.  In CCALD, the ABCD1 gene is mutated, leading to the inability of patients to metabolize very long chain fatty acids in cells of the brain."], "t": []}], "preferred_name": "Lenti-D/ABCD1-transduced Autologous Hematopoietic Stem Cells", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1953382", "l": "Forward primer", "d": [], "t": []}], "preferred_name": "Forward primer", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5157241", "l": "CD10+CD25+ cells | Blood | Cell markers", "d": [], "t": []}], "preferred_name": "CD10+CD25+ cells | Blood | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": 75.38868324457971, "identifiers": [{"i": "UMLS:C1708916", "l": "Malignant Spindle Endothelial Cell", "d": [], "t": []}, {"i": "NCIT:C53405", "l": "Malignant Spindle Endothelial Cell", "d": [], "t": []}], "preferred_name": "Malignant Spindle Endothelial Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C4763651", "l": "Allogeneic Tri-functional Anti-CD19 CAR-NK Cells", "d": [], "t": []}, {"i": "NCIT:C157484", "l": "Allogeneic Tri-functional Anti-CD19 CAR-NK Cells", "d": ["A preparation of allogeneic natural killer (NK) cells transduced with a retroviral vector expressing the immunostimulatory cytokine interleukin-15 (IL-15) and encoding a chimeric antigen receptor (CAR) specific for the tumor-associated antigen (TAA) cluster of differentiation 19 (CD19) that is coupled to the co-stimulatory domains cluster of differentiation 28 (CD28, T-cell-specific surface glycoprotein CD28), cluster of differentiation 137 (CD137; 4-1BB), and the zeta chain of the T-cell receptor (TCR)/CD3 complex (TCRzeta; CD247; CD3zeta); and a blocker for the inhibitory T-cell receptor programmed cell death protein 1 (PD-1; PDCD1; CD279), with potential immunomodulating and antineoplastic activities. Upon transfusion, the allogeneic tri-functional anti-CD19 CAR-NK cells recognize, bind to and induce selective cytotoxicity in CD19-expressing tumor cells. IL-15 enhances the cytotoxic effect of the NK cells and the activated anti-tumor T-cells. The PD-1 inhibitory domain targets and binds to programmed cell death-1 ligand 1 (PD-L1) expressed on tumor cells, thereby preventing the binding of the PD-1 on T-lymphocytes to its ligand, PD-L1 on tumor cells. This prevents PD-1/PD-L1-mediated inhibition of T-lymphocytes and leads to the activation and expansion of T-cells resulting in a cytotoxic T-lymphocyte (CTL) response against tumor cells, thereby enhancing the elimination of tumor cells. CD19 antigen is a B-cell specific cell surface antigen expressed in all B-cell lineage malignancies. The co-stimulatory signaling domains enhance both proliferation of T-cells and anti-tumor activity."], "t": []}], "preferred_name": "Allogeneic Tri-functional Anti-CD19 CAR-NK Cells", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1182791", "l": "Glomerular endothelial cell", "d": [], "t": []}], "preferred_name": "Glomerular endothelial cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4307104", "l": "MOL NN_4 Plin3 mature myelinating oligodendrocyte (Mmus)", "d": ["A mature myelinating oligodendrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Prr5l (Mmus), Hapln2 (Mmus), Enpp6 (Mmus), Grm7 (Mmus). It is distinguished from other MOL NN_4 cells by expression of Plin3, Grm7. These cells are located in the Medulla, brain . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5284 MOL NN_4."], "t": []}], "preferred_name": "MOL NN_4 Plin3 mature myelinating oligodendrocyte (Mmus)", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0000976", "l": "IgA short lived plasma cell", "d": ["A short lived plasma cell that secretes IgA. These cells may be found in the bone marrow as well as in the mucosal immune system."], "t": []}], "preferred_name": "IgA short lived plasma cell", "taxa": []}
{"type": "biolink:Cell", "ic": 59.98073836020729, "identifiers": [{"i": "CL:0000458", "l": "serotonin secreting cell", "d": ["A cell type that secretes 5-Hydroxytryptamine (serotonin)."], "t": []}], "preferred_name": "serotonin secreting cell", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "UMLS:C1513969", "l": "Neoplastic Fusiform Cell", "d": [], "t": []}, {"i": "NCIT:C36963", "l": "Neoplastic Fusiform Cell", "d": [], "t": []}], "preferred_name": "Neoplastic Fusiform Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 92.76600187037766, "identifiers": [{"i": "UMLS:C0206511", "l": "Hair Cells, Vestibular", "d": [], "t": []}, {"i": "NCIT:C12632", "l": "Vestibular Hair Cell", "d": ["A sensory receptor cell, located within the vestibular system, that detects and transduces head movements into neural impulses that are transmitted by vestibular afferent nerves to the brain."], "t": []}, {"i": "MESH:D018069", "l": "Hair Cells, Vestibular", "d": [], "t": []}], "preferred_name": "Hair Cells, Vestibular", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5400722", "l": "Natural Killer Cell", "d": [], "t": []}], "preferred_name": "Natural Killer Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 87.18682603146104, "identifiers": [{"i": "CL:1001602", "l": "cerebral cortex endothelial cell", "d": ["A distinct endothelial cell forming the walls of the capillaries within the cerebral cortex."], "t": []}], "preferred_name": "cerebral cortex endothelial cell", "taxa": []}
{"type": "biolink:Cell", "ic": 85.53200374075534, "identifiers": [{"i": "UMLS:C1519070", "l": "Physaliphorous Cell", "d": [], "t": []}, {"i": "NCIT:C36739", "l": "Physaliphorous Cell", "d": [], "t": []}], "preferred_name": "Physaliphorous Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:1000083", "l": "stratified keratinized epithelial stem cell", "d": [], "t": []}], "preferred_name": "stratified keratinized epithelial stem cell", "taxa": []}
{"type": "biolink:Cell", "ic": 84.21065366064373, "identifiers": [{"i": "CL:0000503", "l": "theca cell", "d": ["A specialized stromal cell that forms the theca layer outside the basal lamina lining the ovarian follicle, appearing during the secondary follicle stage."], "t": []}], "preferred_name": "theca cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5854582", "l": "RD13-02", "d": [], "t": []}, {"i": "NCIT:C200796", "l": "Anti-CD7 CAR-T Cells RD13-02", "d": ["A preparation of T-lymphocytes that have been genetically engineered to express a chimeric antigen receptor (CAR) directed against the tumor-associated antigen (TAA) CD7, with potential immunostimulating and antineoplastic activities. Upon administration, anti-CD7 CAR-T cells RD13-02 specifically target and kill CD7-expressing tumor cells. CD7 is a transmembrane glycoprotein expressed by T-cells and natural killer (NK) cells and their precursors. It is expressed in the majority of lymphoblastic T-cell leukemias and lymphomas and in a subset of peripheral T-cell lymphomas."], "t": []}], "preferred_name": "RD13-02", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5978065", "l": "Colony forming unit granulocyte macrophage | Blood product unit | Cell markers", "d": [], "t": []}], "preferred_name": "Colony forming unit granulocyte macrophage | Blood product unit | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1267884", "l": "Lymphocyte positive for CD18 antigen", "d": [], "t": []}, {"i": "SNOMEDCT:117561004", "l": "", "d": [], "t": []}], "preferred_name": "Lymphocyte positive for CD18 antigen", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4033048", "l": "respiratory tract suprabasal cell", "d": ["A respiratory epithelial cell derived from a basal cell, with a topographic nuclear position between the basal and luminal cells of the airway epithelium. This non-basal, intermediate progenitor cell has limited proliferative capacity and can differentiate into multiciliated, secretory, or rare airway cells (ionocytes, tuft cells, neuroendocrine cells). It shares some ultrastructural features with basal cells but lacks the defined characteristics of fully differentiated cellular phenotypes."], "t": []}], "preferred_name": "respiratory tract suprabasal cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5157330", "l": "CD16+CD57+ | White blood cells | Cell markers", "d": [], "t": []}], "preferred_name": "CD16+CD57+ | White blood cells | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4307106", "l": "MOL NN_4 Art3 mature myelinating oligodendrocyte (Mmus)", "d": ["A mature myelinating oligodendrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Apod (Mmus), Klk6 (Mmus), Dlc1 (Mmus). It is distinguished from other MOL NN_4 cells by expression of Art3. These cells are located in the Medulla, Pons, brain . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5286 MOL NN_4."], "t": []}], "preferred_name": "MOL NN_4 Art3 mature myelinating oligodendrocyte (Mmus)", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5853363", "l": "Allogeneic umbilical cord mesenchymal stem cells", "d": [], "t": []}], "preferred_name": "Allogeneic umbilical cord mesenchymal stem cells", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C4764285", "l": "Autologous Cytoplasmic Activated PD-1 CAR T-cells", "d": [], "t": []}, {"i": "NCIT:C158599", "l": "Autologous Cytoplasmic Activated PD-1 CAR T-cells", "d": ["A preparation of autologous T-lymphocytes engineered to express a chimeric antigen receptor (CAR) specific for the tumor-associated antigen (TAA) cluster of differentiation 19 (CD19), carrying cytoplasmic activated programmed cell death 1 (PD1; PDCD1; CD279; programmed death-1), with potential antineoplastic activity. Upon intravenous administration, autologous cytoplasmic activated PD-1 CAR T-cells target, bind to, and induce selective toxicity in CD19-expressing tumor cells. The cytoplasmic activated PD1, a negative immunoregulatory human cell surface receptor, normally binds to programmed cell death-1 ligand 1 (PD-L1; cluster of differentiation 274; CD274) on tumor cells, causing T-cell inactivation. By preventing PD1/PD-L1 signaling, T-cell exhaustion is abrogated, and T-cell activation is enhanced leading to an increased cytotoxic T-lymphocyte (CTL)-mediated anti-tumor immune response against PD-L1-expressing tumor cells. CD19 is a B-cell-specific cell surface antigen overexpressed in B-cell lineage tumors."], "t": []}], "preferred_name": "Autologous Cytoplasmic Activated PD-1 CAR T-cells", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5418871", "l": "Autologous Multi-lineage Potential Cells", "d": [], "t": []}, {"i": "NCIT:C170908", "l": "Autologous Multi-lineage Potential Cells", "d": ["A preparation of autologous multi-lineage potential cells (AMPC) which were induced to de-differentiate from somatic leukocytes from peripheral blood, with potential immunomodulating and antineoplastic activities. Upon introduction into the patient, the AMPC may help replace the abnormal cells in the body to create healthy bone marrow in the treatment of acute myeloid leukemia (AML)."], "t": []}], "preferred_name": "Autologous Multi-lineage Potential Cells", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0001073", "l": "CD34-negative, CD56-positive, CD117-positive innate lymphoid cell, human", "d": ["An innate lymphoid cell in the human with the phenotype CD34-negative, CD56-positive, CD117-positive.Thie cell type may include precusors to NK cells and ILC3 cells."], "t": []}], "preferred_name": "CD34-negative, CD56-positive, CD117-positive innate lymphoid cell, human", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1267919", "l": "Lymphocyte positive for CD41A antigen", "d": [], "t": []}, {"i": "SNOMEDCT:117587004", "l": "", "d": [], "t": []}], "preferred_name": "Lymphocyte positive for CD41A antigen", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0002501", "l": "type D1 enteroendocrine cell", "d": ["A P/D1 enteroendocrine cell that is argyrophilic and stores vasoactive intestinal polypeptide."], "t": []}, {"i": "UMLS:C2333726", "l": "Type D1 enteroendocrine cell", "d": [], "t": []}], "preferred_name": "type D1 enteroendocrine cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1267992", "l": "Lymphocyte positive for CD106 antigen", "d": [], "t": []}, {"i": "SNOMEDCT:117432003", "l": "", "d": [], "t": []}], "preferred_name": "Lymphocyte positive for CD106 antigen", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4323724", "l": "Diencephalic neural crest cell group", "d": [], "t": []}], "preferred_name": "Diencephalic neural crest cell group", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1183328", "l": "Cell body of bipolar cell of retina", "d": [], "t": []}], "preferred_name": "Cell body of bipolar cell of retina", "taxa": []}
{"type": "biolink:Cell", "ic": 78.80476858236055, "identifiers": [{"i": "CL:0000937", "l": "pre-natural killer cell", "d": ["Cell committed to natural killer cell lineage that has the phenotype CD122-positive, CD34-positive, and CD117-positive. This cell type lacks expression of natural killer receptor proteins."], "t": []}], "preferred_name": "pre-natural killer cell", "taxa": []}
{"type": "biolink:Cell", "ic": 78.29800561113302, "identifiers": [{"i": "UMLS:C1881357", "l": "Large Adenocarcinoma Cell with Eosinophilic Cytoplasm", "d": [], "t": []}, {"i": "NCIT:C61110", "l": "Large Adenocarcinoma Cell with Eosinophilic Cytoplasm", "d": [], "t": []}], "preferred_name": "Large Adenocarcinoma Cell with Eosinophilic Cytoplasm", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5853900", "l": "ACT hESC-RPE", "d": [], "t": []}], "preferred_name": "ACT hESC-RPE", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5421258", "l": "Original Tumor Cell Sample", "d": [], "t": []}, {"i": "NCIT:C172293", "l": "Original Tumor Cell Sample", "d": ["A sample comprised of cells that were isolated from a tumor and have not been cultured or expanded."], "t": []}], "preferred_name": "Original Tumor Cell Sample", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1257913", "l": "Polyploid Cell", "d": [], "t": []}], "preferred_name": "Polyploid Cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5157522", "l": "CD3-CD16+CD56+ (Natural killer) cells | XXX | Cell markers", "d": [], "t": []}], "preferred_name": "CD3-CD16+CD56+ (Natural killer) cells | XXX | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C3652916", "l": "chondrocytes, autologous", "d": [], "t": []}], "preferred_name": "chondrocytes, autologous", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5401677", "l": "CYP-001", "d": [], "t": []}, {"i": "NCIT:C201558", "l": "iPSC-derived MSCs CYP-001", "d": ["A preparation of allogeneic mesenchymal stem cells (MSCs) derived from induced pluripotent stem cells (iPSCs), with potential immunomodulating activity. iPSCs are derived from one healthy adult donor and are expanded and differentiated into mesenchymoangioblasts (MCAs), which are further expanded and cultured, upon which MSCs are formed and further expanded. Upon intravenous administration and following allogeneic hematopoietic stem cell transplantation (HSCT), the iPSC-derived MSCs CYP-001 may attenuate and prevent acute graft versus host disease (aGvHD)."], "t": []}], "preferred_name": "CYP-001", "taxa": []}
{"type": "biolink:Cell", "ic": 74.24062392510156, "identifiers": [{"i": "UMLS:C1514435", "l": "Primitive Mesenchymal Cell", "d": [], "t": []}, {"i": "NCIT:C36907", "l": "Primitive Mesenchymal Cell", "d": [], "t": []}], "preferred_name": "Primitive Mesenchymal Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0002478", "l": "F4/80-negative adipose macrophage", "d": ["An adipose macrophage that does not express F4/80but is MHC-II-positive. This cell type exhibits autofluorescence under typical flow cyometry conditions."], "t": []}], "preferred_name": "F4/80-negative adipose macrophage", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4033120", "l": "thoracic ganglion TH/NPY neuron", "d": ["A sympathetic neuron that has the soma located in the thoracic ganglion and expresses the marker tyrosine hydroxylase (TH) and neuropeptide Y (NPY)."], "t": []}], "preferred_name": "thoracic ganglion TH/NPY neuron", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C4521448", "l": "Derived Peripheral Blood Mononuclear Cell", "d": [], "t": []}, {"i": "NCIT:C138972", "l": "Derived Peripheral Blood Mononuclear Cell", "d": ["Mononuclear cells collected from peripheral blood."], "t": []}], "preferred_name": "Derived Peripheral Blood Mononuclear Cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5237228", "l": "Zevorcabtagene autoleucel", "d": [], "t": []}], "preferred_name": "Zevorcabtagene autoleucel", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1517819", "l": "Mouse Pro-B-Lymphocyte", "d": [], "t": []}, {"i": "NCIT:C22575", "l": "Mouse Pro-B-Lymphocyte", "d": [], "t": []}], "preferred_name": "Mouse Pro-B-Lymphocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 59.627903843144594, "identifiers": [{"i": "CL:4023063", "l": "medial ganglionic eminence derived interneuron", "d": ["An interneuron that is derived from the medial ganglionic eminence.", "An interneuron that is derived from the medial ganglionic eminence. In mice and humans, it expresses LHX6 and SOX6."], "t": []}], "preferred_name": "medial ganglionic eminence derived interneuron", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5216282", "l": "Mononuclear cells|NCnc|Pt|Synv fld", "d": [], "t": []}], "preferred_name": "Mononuclear cells|NCnc|Pt|Synv fld", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "UMLS:C1517678", "l": "Koilocytotic Squamous Cell", "d": [], "t": []}, {"i": "NCIT:C36808", "l": "Koilocytotic Squamous Cell", "d": [], "t": []}], "preferred_name": "Koilocytotic Squamous Cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C2338973", "l": "Goblet cell of epithelium of pyloric gland", "d": [], "t": []}], "preferred_name": "Goblet cell of epithelium of pyloric gland", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0000939", "l": "CD16-positive, CD56-dim natural killer cell, human", "d": ["A mature natural killer cell that has the phenotype CD56-low, CD16-positive and which is capable of cytotoxicity and cytokine production."], "t": []}], "preferred_name": "CD16-positive, CD56-dim natural killer cell, human", "taxa": []}
{"type": "biolink:Cell", "ic": 88.20185721311867, "identifiers": [{"i": "UMLS:C1510959", "l": "Atypical Melanocyte", "d": [], "t": []}, {"i": "NCIT:C36867", "l": "Atypical Melanocyte", "d": [], "t": []}], "preferred_name": "Atypical Melanocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:1001595", "l": "rectum glandular cell", "d": ["Glandular cell of rectal epithelium. Example: Goblet cell; enterocytes or absorptive cells; enteroendocrine and M cells."], "t": []}], "preferred_name": "rectum glandular cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C4055455", "l": "Anti-mesothelin iCasp9M28z CAR-transduced Autologous T Lymphocytes", "d": [], "t": []}, {"i": "NCIT:C121782", "l": "Anti-mesothelin iCasp9M28z CAR-transduced Autologous T Lymphocytes", "d": ["Genetically modified, autologous T-lymphocytes transduced with a retroviral vector encoding a chimeric antigen receptor (CAR) specific for mesothelin linked to the signaling domains for the co-stimulatory molecules CD28 and CD3 zeta, as well as the suicide gene inducible caspase 9 (iCasp9 or iC9), with potential immunomodulating and antineoplastic activities. Upon intravenous administration, anti-mesothelin iCasp9M28z CAR-transduced autologous T lymphocytes specifically target and kill mesothelin-expressing tumor cells. iCasp9 consists of a human FK506 drug-binding domain with an F36V mutation (FKBP12-F36V) linked to human caspase 9. If the administered T-cells lead to unacceptable side effects, a dimerizing agent can be administered, which binds to the FKBP12-F36V drug-binding domain and activates caspase 9, resulting in the apoptosis of the administered T-cells. Mesothelin, a tumor-associated antigen, is overexpressed in a variety of cancer cell types."], "t": []}], "preferred_name": "Anti-mesothelin iCasp9M28z CAR-transduced Autologous T Lymphocytes", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C3898205", "l": "NGFR-transduced Autologous T Lymphocytes", "d": [], "t": []}, {"i": "NCIT:C118576", "l": "NGFR-transduced Autologous T Lymphocytes", "d": ["A preparation of autologous, genetically modified T-lymphocytes that are expressing the tumor-associated antigen (TAA) nerve growth factor receptor (NGFR; p75 neurotrophin receptor; p75(NTR); CD271), with potential antineoplastic activity. Upon isolation, transduction, expansion ex vivo, and reintroduction into the patient, the NGFR-transduced autologous T-lymphocytes may induce an immune response and may kill NGF-expressing tumor cells. Dysregulated NGF signaling may promote proliferation and invasion in certain tumor cell types."], "t": []}], "preferred_name": "NGFR-transduced Autologous T Lymphocytes", "taxa": []}
{"type": "biolink:Cell", "ic": 90.871710685482, "identifiers": [{"i": "UMLS:C1513068", "l": "Medium-Sized Neoplastic Myeloblast with Coarse Cytoplasmic Basophilic Granules", "d": [], "t": []}, {"i": "NCIT:C37180", "l": "Medium-Sized Neoplastic Myeloblast with Coarse Cytoplasmic Basophilic Granules", "d": [], "t": []}], "preferred_name": "Medium-Sized Neoplastic Myeloblast with Coarse Cytoplasmic Basophilic Granules", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C2333240", "l": "Non-nucleated solocyte", "d": [], "t": []}], "preferred_name": "Non-nucleated solocyte", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4518153", "l": "Population of all spermatozoa with acrosome defects in portion of fluid", "d": [], "t": []}, {"i": "SNOMEDCT:725234006", "l": "", "d": [], "t": []}], "preferred_name": "Population of all spermatozoa with acrosome defects in portion of fluid", "taxa": []}
{"type": "biolink:Cell", "ic": 27.21684690506909, "identifiers": [{"i": "CL:0000255", "l": "eukaryotic cell", "d": ["Any cell that in taxon some Eukaryota."], "t": []}, {"i": "UMLS:C0015161", "l": "Eukaryotic Cells", "d": [], "t": []}, {"i": "NCIT:C12596", "l": "Eukaryotic Cell", "d": ["A cell with a membrane-bound nucleus."], "t": []}, {"i": "MESH:D005057", "l": "Eukaryotic Cells", "d": [], "t": []}], "preferred_name": "eukaryotic cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C2324490", "l": "Set of B4 serotoninergic cells", "d": [], "t": []}], "preferred_name": "Set of B4 serotoninergic cells", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:1000468", "l": "myoepithelial cell of acinus of lactiferous gland", "d": ["A myoepithelial cell that is part of the acinus of lactiferous gland."], "t": []}, {"i": "UMLS:C1184107", "l": "Myoepithelial cell of acinus of lactiferous gland", "d": [], "t": []}], "preferred_name": "myoepithelial cell of acinus of lactiferous gland", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5170916", "l": "Leukocytes | Bile fluid | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Leukocytes | Bile fluid | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": 84.21065366064373, "identifiers": [{"i": "CL:1001432", "l": "kidney collecting duct intercalated cell", "d": ["Any renal intercalated cell that is part of some collecting duct of renal tubule."], "t": []}, {"i": "UMLS:C1519718", "l": "Intercalated cell of collecting duct of renal tubule", "d": [], "t": []}, {"i": "NCIT:C13146", "l": "Intercalated Cell", "d": ["The intercalated cell is an epithelial cell of the renal collecting tubule that is specialized for H+ and HCO3 transport. These cells exist in two types, [alpha] and [beta]. The [alpha] cell secretes H+ into the lumen by an apical H+ ATPase and a basolateral Cl:HCO3. The [beta] cell secretes HCO3- into the lumen by an apical Cl:HCO3 and a basolateral H+ ATPase."], "t": []}], "preferred_name": "kidney collecting duct intercalated cell", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "CL:0000569", "l": "cardiac mesenchymal cell", "d": ["A mesenchymal cell found in the developing heart and that develops into some part of the heart.  These cells derive from intra- and extra-cardiac sources, including the endocardium, epicardium, neural crest, and second heart field."], "t": []}], "preferred_name": "cardiac mesenchymal cell", "taxa": []}
{"type": "biolink:Cell", "ic": 90.871710685482, "identifiers": [{"i": "CL:0000923", "l": "CD4-positive type I NK T cell", "d": ["A type I NK T cell that has the phenotype CD4-positive."], "t": []}], "preferred_name": "CD4-positive type I NK T cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4042022", "l": "astrocyte-restricted precursor", "d": ["A progenitor cell of the central nervous system that differentiates exclusively onto astrocytes. This progenitor cell expresses CD44 and S100 calcium-binding protein B."], "t": []}], "preferred_name": "astrocyte-restricted precursor", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C3827031", "l": "Activated Marrow Infiltrating Lymphocytes", "d": [], "t": []}, {"i": "NCIT:C111759", "l": "Activated Marrow Infiltrating Lymphocytes", "d": ["A preparation of cells, which consists of autologous marrow infiltrating lymphocytes (MILs), that are manipulated in vitro, with potential antitumor and immune stimulating activities. MILs are harvested from autologous bone marrow from multiple myeloma patients and, in vitro, are exposed to and activated by anti-CD3/anti-CD28 monoclonal antibodies covalently attached to super-paramagnetic microbeads. After removal of the beads and expansion of the cells in culture, the activated MILs (aMILs) are re-introduced into the patient. The aMILs possess enhanced myeloma specificity, and are able to infiltrate the tumor microenvironment and initiate tumor cell lysis. CD3 and CD28, co-stimulatory molecules expressed on the surface of T-lymphocytes, play a key role in the activation of T-cells."], "t": []}], "preferred_name": "Activated Marrow Infiltrating Lymphocytes", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0002624", "l": "paneth cell of the appendix", "d": ["A paneth cell of the appendix."], "t": []}], "preferred_name": "paneth cell of the appendix", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5216237", "l": "Leukocytes|NCnc|Pt|Pericard fld", "d": [], "t": []}], "preferred_name": "Leukocytes|NCnc|Pt|Pericard fld", "taxa": []}
{"type": "biolink:Cell", "ic": 92.76600187037766, "identifiers": [{"i": "UMLS:C1512101", "l": "Dysplastic Erythroblast", "d": [], "t": []}, {"i": "NCIT:C37056", "l": "Dysplastic Erythroblast", "d": [], "t": []}], "preferred_name": "Dysplastic Erythroblast", "taxa": []}
{"type": "biolink:Cell", "ic": 87.18682603146104, "identifiers": [{"i": "CL:0000395", "l": "procrystal cell", "d": ["A precursor of mature crystal cells."], "t": []}], "preferred_name": "procrystal cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:2000055", "l": "liver dendritic cell", "d": ["Any dendritic cell that is part of a liver."], "t": []}], "preferred_name": "liver dendritic cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0002317", "l": "external limiting cell of vestibular epithelium", "d": ["An external limiting cell found in the vestibular epithelium."], "t": []}, {"i": "UMLS:C1184931", "l": "External limiting cell of vestibular epithelium", "d": [], "t": []}], "preferred_name": "external limiting cell of vestibular epithelium", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "MESH:D016131", "l": "Lymphocyte Subsets", "d": [], "t": []}], "preferred_name": "Lymphocyte Subsets", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0333828", "l": "Myeloid cell containing Auer rod(s)", "d": [], "t": []}, {"i": "SNOMEDCT:74787005", "l": "", "d": [], "t": []}], "preferred_name": "Myeloid cell containing Auer rod(s)", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5163541", "l": "Epithelial cells | Stool | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Epithelial cells | Stool | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": 92.76600187037766, "identifiers": [{"i": "CL:0002526", "l": "CD14-positive dermal dendritic cell", "d": ["A dermal dendritic cell that is CD1a-negative and CD14-positive."], "t": []}], "preferred_name": "CD14-positive dermal dendritic cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4267787", "l": "CD27+CD45RA- cell", "d": [], "t": []}, {"i": "SNOMEDCT:1373176005", "l": "", "d": [], "t": []}], "preferred_name": "CD27+CD45RA- cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1440290", "l": "CD3+CD8+CD45RA+CD45RO- cell", "d": [], "t": []}, {"i": "SNOMEDCT:1373268002", "l": "", "d": [], "t": []}], "preferred_name": "CD3+CD8+CD45RA+CD45RO- cell", "taxa": []}
{"type": "biolink:Cell", "ic": 90.871710685482, "identifiers": [{"i": "UMLS:C1515214", "l": "Tara ES Cell Line", "d": [], "t": []}, {"i": "NCIT:C20280", "l": "Tara ES Cell Line", "d": [], "t": []}], "preferred_name": "Tara ES Cell Line", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "MESH:D052940", "l": "Merozoites", "d": [], "t": []}], "preferred_name": "Merozoites", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5171661", "l": "Lymphocytes | Fetus | Blood | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Lymphocytes | Fetus | Blood | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5557411", "l": "CRISPR-Cas9 Engineered TGFbRII-deleted Anti-EGFR CAR T-cells", "d": [], "t": []}, {"i": "NCIT:C182002", "l": "CRISPR-Cas9 Engineered TGFbRII-deleted Anti-EGFR CAR T-cells", "d": ["A preparation of human T-lymphocytes genetically engineered to express an anti-epidermal growth factor receptor (EGFR) chimeric antigen receptor (CAR) gene and gene-edited with the clustered regularly interspaced short palindromic repeats (CRISPR)-Cas9 nuclease complex to disrupt expression of transforming growth factor-beta receptor II (TGFbRII), with potential immunostimulatory and antineoplastic activities. Upon administration, the CRISPR-Cas9 engineered TGFbRII-deleted anti-EGFR CAR T-cells target and bind to the EGFR antigen on tumor cell surfaces; subsequently, EGFR-expressing tumor cells may be lysed. EGFR, overexpressed by a variety of cancer cell types, plays a key role in tumor cell proliferation, tumor angiogenesis and radio- and chemoresistance. By knocking out the expression of TGFbRII, the immunosuppressive cytokine TGF-beta is unable to bind to the T-cells and prevent the activation of the T-cells. TGF-beta contributes to the immunosuppressive nature of the tumor microenvironment (TME), and plays a key role in promoting tumor initiation, metastasis, and suppressing anti-tumor immunity."], "t": []}], "preferred_name": "CRISPR-Cas9 Engineered TGFbRII-deleted Anti-EGFR CAR T-cells", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4245839", "l": "Set of specialized cardiac muscle cells", "d": [], "t": []}], "preferred_name": "Set of specialized cardiac muscle cells", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C2987368", "l": "Autologous CD8 Positive PBL Sensitized to Drosophila Cell-Presented Melanoma Peptides", "d": [], "t": []}, {"i": "NCIT:C95715", "l": "Autologous CD8 Positive PBL Sensitized to Drosophila Cell-Presented Melanoma Peptides", "d": ["A preparation of autologous CD8+ (cytotoxic) human peripheral blood lymphocytes (PBLs) sensitized to Drosophila cell-presented melanoma peptides, with potential immunostimulating and antineoplastic activities. Autologous CD8+ T-lymphocytes, isolated from a melanoma patient, are exposed in vitro to melanoma peptide-pulsed HLA-A2-expressing Drosophila cells, expanded, and reintroduced into the patient; these tumor-reactive T-cells may stimulate a host immune response against tumor cells expressing the melanoma antigens, resulting in tumor cell lysis. Drosophila cells, which do not express any native MHC molecules, have been shown to potently stimulate tumor-reactivity in vitro from human peripheral blood lymphocytes (PBL) when stably transfected with human MHC molecules and appropriate adhesion and costimulatory molecules."], "t": []}], "preferred_name": "Autologous CD8 Positive PBL Sensitized to Drosophila Cell-Presented Melanoma Peptides", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5216238", "l": "Leukocytes|NCnc|Pt|Periton fld", "d": [], "t": []}], "preferred_name": "Leukocytes|NCnc|Pt|Periton fld", "taxa": []}
{"type": "biolink:Cell", "ic": 77.82747199602274, "identifiers": [{"i": "CL:0000589", "l": "cochlear inner hair cell", "d": ["A bulbous cell that is medially placed in one row in the organ of Corti. In contrast to the outer hair cells, the inner hair cells are fewer in number, have fewer sensory hairs, and are less differentiated."], "t": []}], "preferred_name": "cochlear inner hair cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1524008", "l": "Mouse Natural Killer Cell", "d": [], "t": []}, {"i": "NCIT:C22595", "l": "Mouse Natural Killer Cell", "d": [], "t": []}], "preferred_name": "Mouse Natural Killer Cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0229617", "l": "Medium sized lymphocyte", "d": [], "t": []}, {"i": "SNOMEDCT:52180000", "l": "", "d": [], "t": []}], "preferred_name": "Medium sized lymphocyte", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5219005", "l": "Epithelial cells|NCnc|Urine", "d": [], "t": []}], "preferred_name": "Epithelial cells|NCnc|Urine", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0225466", "l": "Structure of anterior cells of ethmoid sinus", "d": [], "t": []}, {"i": "SNOMEDCT:26357003", "l": "", "d": [], "t": []}], "preferred_name": "Structure of anterior cells of ethmoid sinus", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0002236", "l": "basal epithelial cell of prostatic duct", "d": ["A cell that constitutes the basal layer of epithelium in the prostatic duct."], "t": []}, {"i": "UMLS:C1183900", "l": "Basal cell of prostatic duct", "d": [], "t": []}], "preferred_name": "basal epithelial cell of prostatic duct", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0000930", "l": "CD4-negative, CD8-negative type I NK T cell secreting interleukin-4", "d": ["A mature NK T cell that secretes interleukin-4 and enhances Th2 immune responses."], "t": []}], "preferred_name": "CD4-negative, CD8-negative type I NK T cell secreting interleukin-4", "taxa": []}
{"type": "biolink:Cell", "ic": 62.37696150447555, "identifiers": [{"i": "CL:0000408", "l": "male gamete", "d": ["Any male germ cell that has characteristic some haploid and is capable of some fertilization."], "t": []}], "preferred_name": "male gamete", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1955875", "l": "F9 Teratocarcinoma Stem Cells", "d": [], "t": []}], "preferred_name": "F9 Teratocarcinoma Stem Cells", "taxa": []}
{"type": "biolink:Cell", "ic": 76.9766555310214, "identifiers": [{"i": "CL:0000823", "l": "immature natural killer cell", "d": ["A natural killer cell that is developmentally immature and expresses natural killer cell receptors (NKR)."], "t": []}], "preferred_name": "immature natural killer cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5555562", "l": "Anti-GUCY2C CAR-T Cells", "d": [], "t": []}, {"i": "NCIT:C179261", "l": "Anti-GUCY2C CAR-T Cells", "d": ["A preparation of T-lymphocytes that have been genetically modified to express a chimeric antigen receptor (CAR) targeting human guanylate cyclase 2C (GUCY2C; GCC; guanylyl cyclase C; heat-stable enterotoxin receptor; hSTAR), with potential immunostimulating and antineoplastic activities. Upon administration, anti-GUCY2C CAR-T cells target and bind to GUCY2C-expressing tumor cells, thereby inducing selective toxicity in GUCY2C-expressing tumor cells. GUCY2C, a transmembrane receptor expressed on intestinal epithelial cells, is overexpressed on certain tumors of the gastrointestinal (GI) tract."], "t": []}], "preferred_name": "Anti-GUCY2C CAR-T Cells", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5148515", "l": "Plasma cells.abnormal", "d": [], "t": []}], "preferred_name": "Plasma cells.abnormal", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1520104", "l": "WA09 Cell Line", "d": [], "t": []}, {"i": "NCIT:C20310", "l": "WA09", "d": ["Provider: Wisconsin Alumni Research Foundation (WARF), Madison, WI. Information from provider and not independently verified by NIH: Cells are positive for cell markers SSEA-3, SSEA-4, TRA-1-60, TRA-1-81, and alkaline phosphatase; Cells are negative for SSEA-1; Give rise to teratomas containing derivatives of three germ layers in SCID mice; Differentiate in vitro; Cells not yet ready for distribution. Publications: Thomson et al., Science 282, 1145, 1998; Amit et al., Developmental Biology 227, 271, 2000. This cell line meets the criteria for the use of human embryonic stem cells by federally funded researchers."], "t": []}], "preferred_name": "WA09 Cell Line", "taxa": []}
{"type": "biolink:Cell", "ic": 48.85235144894993, "identifiers": [{"i": "CL:0000100", "l": "motor neuron", "d": ["An efferent neuron that passes from the central nervous system or a ganglion toward or to a muscle and conducts an impulse that causes or inhibits movement."], "t": []}, {"i": "UMLS:C0026609", "l": "Motor Neurons", "d": [], "t": []}, {"i": "MESH:D009046", "l": "Motor Neurons", "d": [], "t": []}, {"i": "SNOMEDCT:31513005", "l": "", "d": [], "t": []}], "preferred_name": "motor neuron", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0013485", "l": "Embryonal Carcinoma Stem Cells", "d": [], "t": []}, {"i": "MESH:D054278", "l": "Embryonal Carcinoma Stem Cells", "d": [], "t": []}], "preferred_name": "Embryonal Carcinoma Stem Cells", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0002141", "l": "active chief cell of parathyroid gland", "d": ["A parathyroid chief cell that is actively secreting hormone. Have large Golgi complexes with numerous vesicles and small membrane-bound granules; secretory granules are rare, cytoplasmic glycogen sparse, much of the cytoplasm being occupied by flat sacs of granular endoplasmic reticulum in parallel arrays; in normal humans, inactive chief cells outnumber active chief cells in a ratio of 3-5:1"], "t": []}, {"i": "UMLS:C1181300", "l": "Active chief cell of parathyroid gland", "d": [], "t": []}], "preferred_name": "active chief cell of parathyroid gland", "taxa": []}
{"type": "biolink:Cell", "ic": 75.70995031940328, "identifiers": [{"i": "CL:1001598", "l": "small intestine secretory cell", "d": ["A glandular cell found in the epithelium of the small intestine. Example: Enterocytes, Goblet cells, enteroendocrine cells; Paneth cells; M cells; Somatostatin-secreting Cells (D-cells) ."], "t": []}], "preferred_name": "small intestine secretory cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4510907", "l": "Blast cell positive for CD14 antigen", "d": [], "t": []}, {"i": "SNOMEDCT:724252003", "l": "", "d": [], "t": []}], "preferred_name": "Blast cell positive for CD14 antigen", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5167383", "l": "Histiocytes | Blood | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Histiocytes | Blood | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": 86.30756602822301, "identifiers": [{"i": "CL:0002036", "l": "Slamf1-positive multipotent progenitor cell", "d": ["A hematopoietic progenitor that has some limited self-renewal capability. Cells are lin-negative, Kit-positive, CD34-positive, and Slamf1-positive."], "t": []}], "preferred_name": "Slamf1-positive multipotent progenitor cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5157610", "l": "CD55 cells | Blood | Cell markers", "d": [], "t": []}], "preferred_name": "CD55 cells | Blood | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": 83.11065783093733, "identifiers": [{"i": "CL:4033044", "l": "deuterosomal cell", "d": ["An epithelial cell part of respiratory tract epithelium that is a precursor of a multi-ciliated cell. This cell actively amplifies centrioles, a required step for multiciliogenesis."], "t": []}], "preferred_name": "deuterosomal cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C3496268", "l": "B5 cell group", "d": [], "t": []}], "preferred_name": "B5 cell group", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0553257", "l": "Epithelial cell of renal tubule", "d": [], "t": []}], "preferred_name": "Epithelial cell of renal tubule", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5157283", "l": "CD123 blasts | Bone marrow | Cell markers", "d": [], "t": []}], "preferred_name": "CD123 blasts | Bone marrow | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0334140", "l": "Rod shaped microglia", "d": [], "t": []}, {"i": "SNOMEDCT:42723004", "l": "", "d": [], "t": []}], "preferred_name": "Rod shaped microglia", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5982799", "l": "Encelto", "d": [], "t": []}], "preferred_name": "Encelto", "taxa": []}
{"type": "biolink:Cell", "ic": 84.83823963392128, "identifiers": [{"i": "UMLS:C1708859", "l": "Malignant Acantholytic Squamous Cell", "d": [], "t": []}, {"i": "NCIT:C54236", "l": "Malignant Acantholytic Squamous Cell", "d": [], "t": []}], "preferred_name": "Malignant Acantholytic Squamous Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 61.618323288024854, "identifiers": [{"i": "CL:4023069", "l": "medial ganglionic eminence derived GABAergic cortical interneuron", "d": ["A GABAergic interneuron that develops from the medial ganglionic eminence and has migrated to the cerebral cortex.", "A GABAergic cortical interneuron that develops from the medial ganglionic eminence and has migrated to the cerebral cortex."], "t": []}], "preferred_name": "medial ganglionic eminence derived GABAergic cortical interneuron", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5380985", "l": "Cells.CD8.HLA-A1 CMV specific", "d": [], "t": []}], "preferred_name": "Cells.CD8.HLA-A1 CMV specific", "taxa": []}
{"type": "biolink:Cell", "ic": 86.30756602822301, "identifiers": [{"i": "CL:0002129", "l": "regular atrial cardiac myocyte", "d": ["Regular cardiac myocyte of a cardiac atrium."], "t": []}, {"i": "UMLS:C2334101", "l": "Regular atrial cardiac myocyte", "d": [], "t": []}], "preferred_name": "regular atrial cardiac myocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0000942", "l": "thymic plasmacytoid dendritic cell", "d": ["A plasmacytoid dendritic cell developing in the thymus with phenotype CD11c-negative or low, CD45RA-positive, CD11b-negative, and CD123-positive."], "t": []}], "preferred_name": "thymic plasmacytoid dendritic cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:1001096", "l": "kidney afferent arteriole endothelial cell", "d": ["An endothelial cell that lines the interior surface of the afferent arteriole and maintains vascular tone. This cell responds to changing ion concentrations and blood pressure by releasing vasoactive substances, in order to regulate blood flow into the glomeruli, which is essential for glomerular filtration."], "t": []}], "preferred_name": "kidney afferent arteriole endothelial cell", "taxa": []}
{"type": "biolink:Cell", "ic": 82.62268137420203, "identifiers": [{"i": "UMLS:C1514050", "l": "Neoplastic Neutrophilic Precursor", "d": [], "t": []}, {"i": "NCIT:C37076", "l": "Neoplastic Neutrophilic Precursor", "d": [], "t": []}], "preferred_name": "Neoplastic Neutrophilic Precursor", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5184399", "l": "Unidentified cells | Peritoneal fluid | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Unidentified cells | Peritoneal fluid | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C3640055", "l": "IGF-1R antisense oligodeoxynucleotide-treated autologous glioma cells", "d": [], "t": []}], "preferred_name": "IGF-1R antisense oligodeoxynucleotide-treated autologous glioma cells", "taxa": []}
{"type": "biolink:Cell", "ic": 77.60424150429895, "identifiers": [{"i": "UMLS:C1710037", "l": "Sebocyte", "d": [], "t": []}, {"i": "NCIT:C43337", "l": "Sebocyte", "d": ["An epithelial cell that produces sebum, a thick, semi-fluid substance composed of fat and epithelial debris from the cells of innermost layer of the epithelium."], "t": []}], "preferred_name": "Sebocyte", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1267880", "l": "Lymphocyte positive for both CD16C antigen and CD56 antigen", "d": [], "t": []}, {"i": "SNOMEDCT:117557005", "l": "", "d": [], "t": []}], "preferred_name": "Lymphocyte positive for both CD16C antigen and CD56 antigen", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C2325623", "l": "Pyramidal cell of precentral gyrus of cerebral hemisphere", "d": [], "t": []}, {"i": "SNOMEDCT:89416001", "l": "", "d": [], "t": []}], "preferred_name": "Pyramidal cell of precentral gyrus of cerebral hemisphere", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "CL:0000371", "l": "protoplast", "d": ["The cell protoplasm after removal of the cell wall."], "t": []}, {"i": "UMLS:C0033731", "l": "Protoplasts", "d": [], "t": []}, {"i": "NCIT:C12659", "l": "Protoplast", "d": ["A bacterial cell deprived of its cell wall, for example by growth in an isotonic medium in the presence of antibiotics that block synthesis of the wall peptidoglycan. Alternatively, a plant cell similarly deprived by enzymic treatment."], "t": []}, {"i": "MESH:D011523", "l": "Protoplasts", "d": [], "t": []}], "preferred_name": "protoplast", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5669551", "l": "Donor-derived Haploidentical IL-21-Expanded Natural Killer Cells", "d": [], "t": []}, {"i": "NCIT:C184812", "l": "Donor-derived Haploidentical IL-21-Expanded Natural Killer Cells", "d": ["A population of ex-vivo human interleukin-21 (IL-21) expanded donor-derived human leukocyte antigen (HLA) haploidentical natural killer (haploNK) cells, with potential immunomodulating and antineoplastic activities. Upon administration in patients undergoing HLA-haploidentical hematopoietic cell transplantation, the donor-derived haploidentical IL-21-expanded NK cells target, lyse and destroy tumor cells. IL-21 promotes sustained ex vivo proliferation of human NK cells and enhances its cytotoxic activity."], "t": []}], "preferred_name": "Donor-derived Haploidentical IL-21-Expanded Natural Killer Cells", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C6063391", "l": "CD25+CD127low cell", "d": [], "t": []}, {"i": "SNOMEDCT:1373300009", "l": "", "d": [], "t": []}], "preferred_name": "CD25+CD127low cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5401595", "l": "Allogenic Donor CD362-enriched Human Umbilical Cord-derived Mesenchymal Stem Cells", "d": [], "t": []}], "preferred_name": "Allogenic Donor CD362-enriched Human Umbilical Cord-derived Mesenchymal Stem Cells", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5977926", "l": "Granulocytes | Pericardial fluid | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Granulocytes | Pericardial fluid | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": 92.76600187037766, "identifiers": [{"i": "CL:0000725", "l": "nitrogen fixing cell", "d": ["Any cell that is capable of some nitrogen fixation."], "t": []}], "preferred_name": "nitrogen fixing cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4042038", "l": "rostral primary motorneuron", "d": ["A type of primary motor neuron situated in the rostral region of the spinal cord. RoP neurons extend their axons to innervate the ventral trunk musculature."], "t": []}], "preferred_name": "rostral primary motorneuron", "taxa": []}
{"type": "biolink:Cell", "ic": 83.63771255585968, "identifiers": [{"i": "CL:1000050", "l": "lateral line nerve glial cell", "d": ["Any glial cell that is part of some lateral line nerve."], "t": []}], "preferred_name": "lateral line nerve glial cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1513174", "l": "Metaplastic Hurthle Cell", "d": [], "t": []}, {"i": "NCIT:C36875", "l": "Metaplastic Hurthle Cell", "d": [], "t": []}], "preferred_name": "Metaplastic Hurthle Cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1267955", "l": "Lymphocyte positive for CD62P antigen", "d": [], "t": []}, {"i": "SNOMEDCT:117396003", "l": "", "d": [], "t": []}], "preferred_name": "Lymphocyte positive for CD62P antigen", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0002541", "l": "chorionic membrane mesenchymal stem cell", "d": ["A mesenchymal stem cell of the chorionic membrane."], "t": []}], "preferred_name": "chorionic membrane mesenchymal stem cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C3641685", "l": "Anti-CD20-CAR-CD3zeta-4-1BB-expressing Autologous T-lymphocyte Cells", "d": [], "t": []}, {"i": "NCIT:C104006", "l": "Anti-CD20-CAR-CD3zeta-4-1BB-expressing Autologous T-lymphocyte Cells", "d": ["A preparation of autologous blood T-lymphocytes that have been genetically modified to express a chimeric antigen receptor (CAR) consisting of an anti-CD20 scFv (single chain variable fragment); the cytoplasmic portion of the human TCR-[zeta] molecule; and the co-stimulatory molecule 4-1BB (CD137), with potential immunostimulating and antineoplastic activities. Upon transfusion, anti-CD20-CAR-CD3zeta-4-1BB-expressing autologous T-lymphocyte cells direct T-cells to CD20-expressing tumor cells. This results in cytotoxic T lymphocyte (CTL) and antibody responses against CD20-expressing tumor cells, causing tumor cell lysis. The CD20 antigen, a non-glycosylated cell surface phosphoprotein, is a B-cell specific cell surface antigen expressed in B-cell lineage malignancies. CD3 zeta is one of several membrane-bound polypeptides found in the T-cell receptor (TCR)/CD3 complex and regulates the assembly of complete TCR complexes and their expression on the cell surface. The 4-1BB co-stimulatory molecule signaling domain enhances activation and signaling after recognition of CD20; the inclusion of this signaling domain may increase the antitumor activity compared to the inclusion of the CD3-zeta chain alone."], "t": []}], "preferred_name": "Anti-CD20-CAR-CD3zeta-4-1BB-expressing Autologous T-lymphocyte Cells", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C3828683", "l": "Ovapuldencel-T", "d": [], "t": []}, {"i": "NCIT:C113651", "l": "Ovapuldencel-T", "d": ["A cancer vaccine consisting of autologous dendritic cells (DCs) loaded with autologous, lethally irradiated cancer cells and mixed with the cytokine granulocyte-macrophage colony stimulating factor (GM-CSF), with potential immunostimulatory and antineoplastic activities. Upon vaccination, ovapuldencel-T may stimulate the immune system to exert a cytotoxic T-lymphocyte (CTL) immune response against the repertoire of tumor associated antigens (TAAs) found in the irradiated cancer cells. GM-CSF enhances the activation of dendritic cells (DCs) and promotes antigen presentation to both B- and T-lymphocytes."], "t": []}], "preferred_name": "Ovapuldencel-T", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4042029", "l": "cortical immature neuron", "d": ["An immature neuron of a cerebral cortex. This neuron develops prenatally and remains in an immature state throughout the lifespan of the organism."], "t": []}], "preferred_name": "cortical immature neuron", "taxa": []}
{"type": "biolink:Cell", "ic": 45.660375186563805, "identifiers": [{"i": "CL:0000183", "l": "contractile cell", "d": ["A cell whose primary function is to shorten."], "t": []}], "preferred_name": "contractile cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4307054", "l": "Astro-OLF NN_2 Alk astrocyte (Mmus)", "d": ["A astrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of S1pr1 (Mmus), Chrdl1 (Mmus), Sfrp1 (Mmus), Atp13a4 (Mmus). It is distinguished from other Astro-OLF NN_2 cells by expression of Alk, Atp13a4. These cells are located in the Olfactory areas , in or close to the regions: Anterior olfactory nucleus, Main olfactory bulb, granule layer, Main olfactory bulb, mitral layer . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5234 Astro-OLF NN_2."], "t": []}], "preferred_name": "Astro-OLF NN_2 Alk astrocyte (Mmus)", "taxa": []}
{"type": "biolink:Cell", "ic": 49.32298827122729, "identifiers": [{"i": "CL:0000542", "l": "lymphocyte", "d": ["A lymphocyte is a leukocyte commonly found in the blood and lymph that has the characteristics of a large nucleus, a neutral staining cytoplasm, and prominent heterochromatin."], "t": []}], "preferred_name": "lymphocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 92.76600187037766, "identifiers": [{"i": "CL:1000838", "l": "kidney proximal convoluted tubule epithelial cell", "d": ["Any epithelial cell of proximal tubule that is part of some proximal convoluted tubule and has part some brush border."], "t": []}], "preferred_name": "kidney proximal convoluted tubule epithelial cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5175606", "l": "Other cells | Peritoneal fluid | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Other cells | Peritoneal fluid | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4030033", "l": "valve endothelial cell", "d": ["An endothelial cell that lines a surface of a cardiac valve leaflet. Along with valve interstitial cells, a valve endothelial cell maintains tissue homeostasis for the function of cardiac valves through secreting biochemical signals, matrix proteins and matrix remodeling enzymes."], "t": []}], "preferred_name": "valve endothelial cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0002597", "l": "smooth muscle cell of bladder", "d": ["A smooth muscle cell of the bladder."], "t": []}], "preferred_name": "smooth muscle cell of bladder", "taxa": []}
{"type": "biolink:Cell", "ic": 57.161566270344146, "identifiers": [{"i": "CL:0000457", "l": "biogenic amine secreting cell", "d": [], "t": []}], "preferred_name": "biogenic amine secreting cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5216264", "l": "Malignant cells|NCnc|Pt|Synv fld", "d": [], "t": []}], "preferred_name": "Malignant cells|NCnc|Pt|Synv fld", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4052016", "l": "pituitary gland capillary endothelial cell", "d": ["A capillary endothelial cell that is part of the pituitary gland. This cell is characterized by its fenestrated structure which facilitates the efficient transport of hormones and other signaling molecules, essential for endocrine signalling."], "t": []}], "preferred_name": "pituitary gland capillary endothelial cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5155146", "l": "Bladder cells | Urine sediment | Urinalysis", "d": [], "t": []}], "preferred_name": "Bladder cells | Urine sediment | Urinalysis", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5170928", "l": "Leukocytes | Ear | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Leukocytes | Ear | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4510890", "l": "Blast cell positive for CD5 antigen", "d": [], "t": []}, {"i": "SNOMEDCT:724316000", "l": "", "d": [], "t": []}], "preferred_name": "Blast cell positive for CD5 antigen", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:2000052", "l": "umbilical artery endothelial cell", "d": ["Any endothelial cell of artery that is part of a umbilical cord."], "t": []}], "preferred_name": "umbilical artery endothelial cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0002216", "l": "intermediate muscle cell", "d": ["An intermediate muscle cell that has characteristics of both fast and slow muscle cells."], "t": []}, {"i": "UMLS:C2333350", "l": "Muscle Fibers, Intermediate", "d": [], "t": []}], "preferred_name": "intermediate muscle cell", "taxa": []}
{"type": "biolink:Cell", "ic": 64.75978638969531, "identifiers": [{"i": "UMLS:C1518220", "l": "Malignant Neuroendocrine Large Cell", "d": [], "t": []}, {"i": "NCIT:C36821", "l": "Malignant Neuroendocrine Large Cell", "d": [], "t": []}], "preferred_name": "Malignant Neuroendocrine Large Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 75.2337427109536, "identifiers": [{"i": "CL:4052061", "l": "epidermal keratinocyte", "d": ["A keratinocyte of the skin epidermis that synthesizes keratin and undergoes successive stages of differentiation as it migrates from the basal layer to the cornified (stratum corneum) layer. These differentiation stages include the basal, spinous (prickle), and granular cell layers. This cell is central to epidermal homeostasis, mediating wound healing, immune modulation, including the secretion of cytokines and chemokines that recruit neutrophils (Simmons and Gallo, 2024), and intercellular communication with adjacent melanocytes (Marrapodi and Bellei, 2024)."], "t": []}], "preferred_name": "epidermal keratinocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "CL:0002654", "l": "epithelial cell of stratum corneum of esophageal epithelium", "d": ["An epithelial cell of stratum corneum of esophageal epithelium."], "t": []}, {"i": "UMLS:C1182710", "l": "Epithelial cell of stratum corneum of esophagus", "d": [], "t": []}], "preferred_name": "epithelial cell of stratum corneum of esophageal epithelium", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5854422", "l": "Autologous Base Edited CD34+ HSPCs BEAM-101", "d": [], "t": []}, {"i": "NCIT:C199468", "l": "Autologous Base Edited CD34+ HSPCs BEAM-101", "d": ["A population of autologous cluster of differentiation 34 (CD34)-positive human hematopoietic stem and progenitor cells (HSPCs) ex-vivo base-edited with fusions of a deaminase and clustered regularly interspaced short palindromic repeats (CRISPR)-Cas ribonucleoprotein, with potential usage for transplantation in patients with sickle cell disease (SCD). CD34-positive HSPCs are isolated from human blood upon apheresis and are genetically modified and base-edited ex vivo to disrupt the HBG1/HBG2 gene promoter motif bound by the transcriptional repressor B-cell lymphoma/leukemia 11A (BCL11A) gene. This increases the expression of fetal hemoglobin (HbF) and inhibits hemoglobin S (HbS) polymerization in erythrocytes that differentiate from BEAM-101. Upon infusion back into the patient following myeloablative, conditioning chemotherapy, BEAM-101 can populate the bone marrow and differentiate into a variety of blood cell types including lymphoid cells, myeloid cells and erythroblasts. The increased production of high levels of HbF in red blood cells (RBCs) compensates for the defective or reduced adult hemoglobin (Hb) in patients with SCD. HbF is a form of the oxygen carrying Hb that is naturally present at birth and is then replaced by the adult form of hemoglobin."], "t": []}], "preferred_name": "Autologous Base Edited CD34+ HSPCs BEAM-101", "taxa": []}
{"type": "biolink:Cell", "ic": 46.55608122223953, "identifiers": [{"i": "UMLS:C1510734", "l": "Abnormal Squamous Cell", "d": [], "t": []}, {"i": "NCIT:C36772", "l": "Abnormal Squamous Cell", "d": [], "t": []}], "preferred_name": "Abnormal Squamous Cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0682699", "l": "neuron type by location", "d": [], "t": []}], "preferred_name": "neuron type by location", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4023089", "l": "nest basket cell", "d": ["A basket cell which has simpler dendritic arbors (compared to small or large basket cells), and an axonal plexus of intermediate density, composed of a few long, smooth axonal branches."], "t": []}], "preferred_name": "nest basket cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4086010", "l": "betibeglogene autotemcel", "d": [], "t": []}, {"i": "MESH:C000721148", "l": "betibeglogene autotemcel", "d": [], "t": []}], "preferred_name": "betibeglogene autotemcel", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1440247", "l": "CD11c+CD20+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:1372964000", "l": "", "d": [], "t": []}], "preferred_name": "CD11c+CD20+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": 87.18682603146104, "identifiers": [{"i": "UMLS:C1518170", "l": "Malignant Clear Squamous Cell", "d": [], "t": []}, {"i": "NCIT:C36814", "l": "Malignant Clear Squamous Cell", "d": [], "t": []}], "preferred_name": "Malignant Clear Squamous Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4033086", "l": "lipid-associated macrophage", "d": ["A tissue-resident macrophage that is associated with lipids. This cell responsible of anti-inflammatory functions, lipid accumulation and enhancing phagocytosis (Wculek et al., 2022, Liu et al., 2022). In mice and humans, a lipid-associated macrophage is characterized by the marker Trem2 (Jaitlin et al., 2019)."], "t": []}], "preferred_name": "lipid-associated macrophage", "taxa": []}
{"type": "biolink:Cell", "ic": 88.20185721311867, "identifiers": [{"i": "CL:4033083", "l": "squamous granulosa cell", "d": ["A granulosa cell that has a squamous morphology and form a single layer around the oocyte in primordial follicles. This cell develops directly into a cuboidal granulosa cell during the primordial-to-primary follicle transition."], "t": []}], "preferred_name": "squamous granulosa cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5157673", "l": "CD8+HLA-DR+ cells | Blood | Cell markers", "d": [], "t": []}], "preferred_name": "CD8+HLA-DR+ cells | Blood | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1267989", "l": "Lymphocyte positive for CD103 antigen", "d": [], "t": []}, {"i": "SNOMEDCT:117429001", "l": "", "d": [], "t": []}], "preferred_name": "Lymphocyte positive for CD103 antigen", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C4727680", "l": "Expanded Cord Blood Stem Cells Mixed with Engineered Human Endothelial Cells AB-110", "d": [], "t": []}, {"i": "NCIT:C150135", "l": "Expanded Cord Blood Stem Cells Mixed with Engineered Human Endothelial Cells AB-110", "d": ["A population of ex vivo expanded, CD34-positive-enriched hematopoietic progenitor cells (HPCs), which are derived from allogeneic human umbilical cord blood (UCB), and are co-cultured and expanded with a proprietary preparation of human endothelial cells (ECs), which are genetically modified with an adenovirus (Ad) vector that includes the Ad E4 region that encodes the ORF1 (E4ORF1) gene, that can be used for transplantation. Upon transplantation of the expanded cord blood stem cells mixed with engineered human ECs AB-110, the UCB-derived cells can differentiate into a variety of cell types and promote blood cell recovery. Compared to bone marrow transplants, these HPCs demonstrate a decreased risk of causing graft-versus-host disease (GvHD), increase survival and enhance the potential for transplant and engraftment in any given patient as there is no need for a matched donor. Compared to HPCs alone, inclusion of the ECs increases blood stem cell count, enhances engraftment potential and increases the chances for blood cell recovery, thereby further increasing the potential for a successful cord blood transplantation. Insertion of the Ad E4ORF1 gene enhances survival and replication of the ECs ex vivo, preserves the ECs' vascular functions and improves the ability of the ECs to secrete angiocrines, which promotes stem cell proliferation and increases engraftment."], "t": []}], "preferred_name": "Expanded Cord Blood Stem Cells Mixed with Engineered Human Endothelial Cells AB-110", "taxa": []}
{"type": "biolink:Cell", "ic": 88.20185721311867, "identifiers": [{"i": "UMLS:C1882051", "l": "Neoplastic Epithelial Small Oval Cell", "d": [], "t": []}, {"i": "NCIT:C60998", "l": "Neoplastic Epithelial Small Oval Cell", "d": [], "t": []}], "preferred_name": "Neoplastic Epithelial Small Oval Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 92.76600187037766, "identifiers": [{"i": "UMLS:C1519515", "l": "Tingible Body Macrophage", "d": [], "t": []}, {"i": "NCIT:C36834", "l": "Tingible Body Macrophage", "d": [], "t": []}], "preferred_name": "Tingible Body Macrophage", "taxa": []}
{"type": "biolink:Cell", "ic": 90.871710685482, "identifiers": [{"i": "CL:4301584", "l": "CB Granule Glut_1 cerebellar granule cell (Mmus)", "d": ["A cerebellar granule cell of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Gabra6 (Mmus), Lmx1a (Mmus). Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Supertype:1154 CB Granule Glut_1."], "t": []}], "preferred_name": "CB Granule Glut_1 cerebellar granule cell (Mmus)", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C3831168", "l": "CD33CAR-CD3zeta-4-1BB-expressing Autologous T-Lymphocytes", "d": [], "t": []}, {"i": "NCIT:C107190", "l": "CD33CAR-CD3zeta-4-1BB-expressing Autologous T-Lymphocytes", "d": ["Autologous T-lymphocytes transduced with a retroviral vector expressing a chimeric antigen receptor (CAR) consisting of an anti-CD33 scFv (single chain variable fragment) coupled to the signaling domain of 4-1BB (CD137) and the zeta chain of the T-cell receptor (TCRzeta), with potential immunomodulating and antineoplastic activities. Upon transfusion, CD33-specific CAR retroviral vector-transduced autologous T lymphocytes target CD33-expressing tumor cells and induce selective toxicity in CD33-expressing tumor cells. Following binding to CD33, the 4-1BB co-stimulatory molecule signaling domain enhances both activation and signaling. Inclusion of the 4-1BB signaling domain may also increase the antitumor activity when compared to the inclusion of the CD3-zeta chain alone. CD33 is expressed on normal non-pluripotent hematopoietic stem cells as well as on myeloid leukemia cells."], "t": []}], "preferred_name": "CD33CAR-CD3zeta-4-1BB-expressing Autologous T-Lymphocytes", "taxa": []}
{"type": "biolink:Cell", "ic": 85.53200374075534, "identifiers": [{"i": "CL:0000795", "l": "CD8-positive, alpha-beta regulatory T cell", "d": ["A CD8-positive, alpha-beta T cell that regulates overall immune responses as well as the responses of other T cell subsets through direct cell-cell contact and cytokine release."], "t": []}], "preferred_name": "CD8-positive, alpha-beta regulatory T cell", "taxa": []}
{"type": "biolink:Cell", "ic": 52.716604393713574, "identifiers": [{"i": "CL:0008001", "l": "hematopoietic precursor cell", "d": ["Any hematopoietic cell that is a precursor of some other hematopoietic cell type."], "t": []}], "preferred_name": "hematopoietic precursor cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5157430", "l": "CD3+CD25+ cells | Blood | Cell markers", "d": [], "t": []}], "preferred_name": "CD3+CD25+ cells | Blood | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5761797", "l": "OriCar-017", "d": [], "t": []}, {"i": "NCIT:C206250", "l": "Autologous Anti-GPRC5D CAR-T Cells OriCAR-017", "d": ["A preparation of autologous T-lymphocytes engineered to express a chimeric antigen receptor (CAR) specific for the tumor-associated antigen (TAA) human G-protein coupled receptor family C group 5 member D (GPRC5D), with potential immunostimulating and antineoplastic activities. Upon leukapheresis, isolation, transduction, expansion ex vivo, and reintroduction into the patient, the autologous anti-GPRC5D CAR-T cells OriCAR-017 specifically recognize and induce selective toxicity in GPRC5D-expressing tumor cells. GPRC5D is overexpressed in certain malignancies, such as multiple myeloma, while minimally expressed in normal, healthy cells. It plays a key role in tumor cell proliferation. OriCAR-017 contains a signal activation domain element that may improve CAR-T cells expansion and durability."], "t": []}], "preferred_name": "OriCar-017", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0541681", "l": "Marrow Monocytes and Plasma Cells", "d": [], "t": []}], "preferred_name": "Marrow Monocytes and Plasma Cells", "taxa": []}
{"type": "biolink:Cell", "ic": 82.62268137420203, "identifiers": [{"i": "CL:0000899", "l": "T-helper 17 cell", "d": ["CD4-positive, alpha-beta T cell with the phenotype RORgamma-t-positive, CXCR3-negative, CCR6-positive, and capable of producing IL-17."], "t": []}, {"i": "UMLS:C2936411", "l": "Th17 Cells", "d": [], "t": []}, {"i": "NCIT:C113815", "l": "T Helper 17 Cell", "d": ["A subset of helper T-lymphocytes which synthesize and secrete the interleukins (IL), IL-17A, -21 and -22. These cytokines mediate inflammation by increasing chemokine production, which leads to the recruitment of both monocytes and neutrophils to sites of infection or inflammation. Th17 cells modulate both host immunity against extracellular bacteria and fungi and inflammation. Overexpression of these cells is associated with tissue injury caused by autoimmune diseases."], "t": []}, {"i": "MESH:D058504", "l": "Th17 Cells", "d": [], "t": []}], "preferred_name": "T-helper 17 cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4300404", "l": "Cells.chromosome region 17p13.1 deletion", "d": [], "t": []}], "preferred_name": "Cells.chromosome region 17p13.1 deletion", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1512049", "l": "Downey Cell", "d": [], "t": []}, {"i": "NCIT:C36736", "l": "Downey Cell", "d": [], "t": []}], "preferred_name": "Downey Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 76.22330125402472, "identifiers": [{"i": "CL:0002072", "l": "nodal myocyte", "d": ["A specialized cardiac myocyte in the sinoatrial and atrioventricular nodes. The cell is slender and fusiform confined to the nodal center, circumferentially arranged around the nodal artery."], "t": []}, {"i": "UMLS:C1179870", "l": "Nodal myocyte", "d": [], "t": []}], "preferred_name": "nodal myocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "CL:0005001", "l": "iridoblast", "d": ["A non-terminally differentiated cell that originates from the neural crest and differentiates into an iridophore."], "t": []}], "preferred_name": "iridoblast", "taxa": []}
{"type": "biolink:Cell", "ic": 73.613037951824, "identifiers": [{"i": "UMLS:C4745055", "l": "Malignant Basal Cell", "d": [], "t": []}, {"i": "NCIT:C156768", "l": "Malignant Basal Cell", "d": [], "t": []}], "preferred_name": "Malignant Basal Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 62.59794428535213, "identifiers": [{"i": "UMLS:C1515138", "l": "Precursor T-Lymphoblast", "d": [], "t": []}, {"i": "NCIT:C33930", "l": "Precursor T-Lymphoblast", "d": ["An immature T-lymphocyte, that has enlarged following stimulation by an antigen, has the capacity to recognize the stimulating antigen and is undergoing proliferation and differentiation either to eliminate the antigen or to a memory state in order to recognize the future appearance of the antigen."], "t": []}], "preferred_name": "Precursor T-Lymphoblast", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C3831561", "l": "Allogeneic HLA-A2/4-1BB ligand-expressing Melanoma Vaccine", "d": [], "t": []}, {"i": "NCIT:C107169", "l": "Allogeneic HLA-A2/4-1BB ligand-expressing Melanoma Vaccine", "d": ["An allogeneic melanoma cell vaccine derived from a cell line with high expression of melanoma associated antigens and genetically modified to express both HLA-A2 and 4-1BB ligand, with potential immunostimulating and antineoplastic activities. Upon administration, the 4-1BB ligand of the allogeneic HLA-A2/4-1BB ligand-expressing melanoma vaccine binds to 4-1BB on activated T-lymphocytes, which induces a strong immune response against HLA-A2 positive melanoma cells."], "t": []}], "preferred_name": "Allogeneic HLA-A2/4-1BB ligand-expressing Melanoma Vaccine", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C2736933", "l": "CD3+CD8+CD45+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:1373090005", "l": "", "d": [], "t": []}], "preferred_name": "CD3+CD8+CD45+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C2339342", "l": "Set of A14 dopaminergic cells", "d": [], "t": []}], "preferred_name": "Set of A14 dopaminergic cells", "taxa": []}
{"type": "biolink:Cell", "ic": 84.83823963392128, "identifiers": [{"i": "UMLS:C1518985", "l": "Perineurial Cell", "d": [], "t": []}, {"i": "NCIT:C41442", "l": "Perineurial Cell", "d": ["A cell that belongs to the supporting tissue surrounding a nerve fiber bundle. It has thin long bipolar cytoplasmic processes, pinocytotic vesicles, fragments of external lamina and/or external lamina-like material, attachment plaques, and desmosome-like junctions."], "t": []}], "preferred_name": "Perineurial Cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1267830", "l": "T lymphocyte positive for CD16 antigen and CD57 antigen", "d": [], "t": []}, {"i": "SNOMEDCT:115416000", "l": "", "d": [], "t": []}], "preferred_name": "T lymphocyte positive for CD16 antigen and CD57 antigen", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C4725911", "l": "CAR.CD19-Redirected T cells", "d": [], "t": []}, {"i": "NCIT:C150671", "l": "Autologous Anti-CD19 CAR-CD3zeta-4-1BB-expressing T-cells", "d": ["A preparation of autologous T-lymphocytes that are engineered to express a chimeric antigen receptor (CAR) composed of an anti-cluster of differentiation 19 (CD19) single chain variable fragment (scFv) linked to the intracellular signaling domains of 4-1BB (CD137) and the zeta chain of the TCR/CD3 complex (TCRzeta; CD247; CD3zeta), with potential immunomodulating and antineoplastic activities. Upon administration of the autologous anti-CD19 CAR-CD3zeta-4-1BB-expressing T-cells, these cells target, bind to and induce selective toxicity in CD19-expressing tumor cells. CD19 antigen is a B-cell specific cell surface antigen expressed in all B-cell lineage malignancies."], "t": []}], "preferred_name": "CAR.CD19-Redirected T cells", "taxa": []}
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{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4052005", "l": "intestinal subserosal fibroblast", "d": ["A fibroblast that is part of the subserosa of intestine. This cell interacts with immune cells and play roles in inflammation and fibrosis. In certain conditions, such as Crohn's disease, subserosal fibroblast may differentiate into myofibroblasts."], "t": []}], "preferred_name": "intestinal subserosal fibroblast", "taxa": []}
{"type": "biolink:Cell", "ic": 89.40238429118027, "identifiers": [{"i": "UMLS:C1512640", "l": "Immature Spindle Cell", "d": [], "t": []}, {"i": "NCIT:C36958", "l": "Immature Spindle Cell", "d": [], "t": []}], "preferred_name": "Immature Spindle Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1522193", "l": "Mouse Schwann Cell", "d": [], "t": []}, {"i": "NCIT:C22632", "l": "Mouse Schwann Cell", "d": [], "t": []}], "preferred_name": "Mouse Schwann Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C2826156", "l": "CD34/TK75 Retroviral Vector-Transduced Donor Lymphocytes", "d": [], "t": []}, {"i": "NCIT:C82409", "l": "CD34/TK75 Retroviral Vector-Transduced Donor Lymphocytes", "d": ["A preparation of donor T-lymphocytes that are transfected with a retroviral vector encoding a chimeric suicide gene consisting of the extracellular and transmembrane domains of human CD34 and mutant 75 of the herpes simplex virus thymidine kinase (HSV-TK75) with potential controllable immunomodulating activity.  Donor T cell therapy following allogeneic hematopoietic stem cell (HSC) transplantation may result in a graft-versus-leukemia (GVL) and help control transplant-related viral infections. In the event that graft-versus-host disease (GVHD) develops due to donor lymphocyte infusion, CD34/TK75-transduced donor lymphocytes may be selectively eliminated by administration of the prodrug antiviral agent ganciclovir GCV.  In CD34/T75-transduced donor lymphocytes, GCV is phosphorylated by expressed HSV-TK75 to its monophosphate form and, subsequently, converted into its active triphosphate form, which specifically kills the donor lymphocytes.  The expressed CD34 moiety of the chimeric suicide gene serves as a selection marker; mutant 75 of HSV-TK confers increased GCV sensitivity."], "t": []}], "preferred_name": "CD34/TK75 Retroviral Vector-Transduced Donor Lymphocytes", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1267849", "l": "Lymphocyte positive for both CD5 antigen and CD8 antigen", "d": [], "t": []}, {"i": "SNOMEDCT:117535003", "l": "", "d": [], "t": []}], "preferred_name": "Lymphocyte positive for both CD5 antigen and CD8 antigen", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5418990", "l": "Allogeneic Anti-BCMA-CAR T-cells PBCAR269A", "d": [], "t": []}, {"i": "NCIT:C171066", "l": "Allogeneic Anti-BCMA-CAR T-cells PBCAR269A", "d": ["A preparation of allogeneic, off-the-shelf, T-lymphocytes that have been genetically modified using a proprietary synthetic nuclease-based system to express a chimeric antigen receptor (CAR) targeting the tumor-associated antigen (TAA) B-cell maturation antigen (BCMA; tumor necrosis factor receptor superfamily member 17; TNFRSF17), with potential immunostimulating and antineoplastic activities. Upon administration, allogeneic anti-BCMA-CAR T-cells PBCAR269A specifically recognize and kill BCMA-expressing tumor cells. BCMA, a receptor for both a proliferation-inducing ligand (APRIL) and B-cell activating factor (BAFF), is a member of the tumor necrosis factor receptor superfamily (TNFRSF). BCMA is found on the surfaces of plasma cells, is overexpressed on malignant plasma cells and plays a key role in plasma cell proliferation and survival."], "t": []}], "preferred_name": "Allogeneic Anti-BCMA-CAR T-cells PBCAR269A", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0000489", "l": "scotopic photoreceptor cell", "d": [], "t": []}], "preferred_name": "scotopic photoreceptor cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5959214", "l": "Autologous Anti-HER2 CAR Monocytes CT-0525", "d": [], "t": []}, {"i": "NCIT:C205637", "l": "Autologous Anti-HER2 CAR Monocytes CT-0525", "d": ["A preparation of autologous monocytes genetically modified to express a chimeric antigen receptor (CAR) specific for the tumor-associated antigen (TAA) human epidermal growth factor receptor 2 (HER2; ErbB2; HER-2), with potential immunostimulating and antineoplastic activities. Upon administration, autologous anti-HER2 CAR monocytes CT-0525 specifically recognize and bind to HER2-expressing tumor cells, and expose the immune system to the HER2 antigen. This may elicit a cytotoxic T-lymphocyte (CTL) response against HER2-expressing tumor cells. HER2 is overexpressed in a variety of cancer cell types and is associated with increased tumor cell proliferation."], "t": []}], "preferred_name": "Autologous Anti-HER2 CAR Monocytes CT-0525", "taxa": []}
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{"type": "biolink:Cell", "ic": 74.50942324134168, "identifiers": [{"i": "UMLS:C1519599", "l": "Transformed Neoplastic Lymphocyte", "d": [], "t": []}, {"i": "NCIT:C40562", "l": "Transformed Neoplastic Lymphocyte", "d": [], "t": []}], "preferred_name": "Transformed Neoplastic Lymphocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 51.37069989535484, "identifiers": [{"i": "CL:3000004", "l": "peripheral sensory neuron", "d": ["A neuron type that is located in a peripheral nervous system and it transmits sensory information from the peripheral (PNS) to the central nervous system (CNS). A sensory neuron converts physical (light, sound, touch) or chemical (such as taste and smell) stimuli into an electrical signal through a process known as sensory transduction. The function of a sensory neuron is to carry informations from the external environment and internal body conditions to the central nervous system for further processing."], "t": []}], "preferred_name": "peripheral sensory neuron", "taxa": []}
{"type": "biolink:Cell", "ic": 59.89074148504091, "identifiers": [{"i": "UMLS:C1514039", "l": "Neoplastic Myeloid Cell", "d": [], "t": []}, {"i": "NCIT:C41063", "l": "Neoplastic Myeloid Cell", "d": [], "t": []}], "preferred_name": "Neoplastic Myeloid Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0000701", "l": "paraganglia type 2 cell", "d": ["Supports paraganglial type 1 cell."], "t": []}], "preferred_name": "paraganglia type 2 cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1624741", "l": "CD3+CD16+CD56+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:1373087004", "l": "", "d": [], "t": []}], "preferred_name": "CD3+CD16+CD56+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:1001124", "l": "kidney cortex peritubular capillary cell", "d": ["An endothelial cell that is part of the peritubular capillary of the renal cortex."], "t": []}], "preferred_name": "kidney cortex peritubular capillary cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1515152", "l": "TE62", "d": [], "t": []}, {"i": "NCIT:C20301", "l": "TE62", "d": ["Provider: Technion University, Haifa, Israel. No information from provider. This cell line meets the criteria for the use of human embryonic stem cells by federally funded researchers."], "t": []}], "preferred_name": "TE62", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C4287750", "l": "JCAR014", "d": [], "t": []}, {"i": "NCIT:C126639", "l": "Autologous Anti-CD19CAR-4-1BB-CD3zeta-EGFRt-expressing CD4+/CD8+ Central Memory T-lymphocytes JCAR014", "d": ["A defined preparation of CD4+ and CD8+ central memory (CM) autologous T-lymphocytes transduced with a lentiviral vector expressing a chimeric antigen receptor (CAR) containing an anti-CD19 single chain variable fragment (scFv) fused to the signaling domains of CD28, 4-1BB (CD137), the zeta chain of the TCR/CD3 complex (CD3-zeta), and a truncated form of the human epidermal growth factor receptor (EGFRt), with potential immunostimulating and antineoplastic activities. Upon intravenous administration, autologous anti-CD19CAR-4-1BB-CD3zeta-EGFRt-expressing CD4+/CD8+CM T-lymphocytes JCAR014 are directed to and induce selective toxicity in CD19-expressing tumor cells. CD19 antigen is a B-cell specific cell surface antigen expressed in all B-cell lineage malignancies. Devoid of both ligand binding domains and tyrosine kinase activity, the expressed EGFRt both facilitates in vivo detection of the administered, transduced T-cells and can promote elimination of those cells through a cetuximab-induced antibody dependent cellular cytotoxicity (ADCC) response. The 4-1BB costimulatory signaling domain enhances both proliferation of T-cells and antitumor activity."], "t": []}], "preferred_name": "JCAR014", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5416839", "l": "Amniotic Epithelial Cells", "d": [], "t": []}], "preferred_name": "Amniotic Epithelial Cells", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5157467", "l": "CD3+HLA-DR+ cells | Bone marrow | Cell markers", "d": [], "t": []}], "preferred_name": "CD3+HLA-DR+ cells | Bone marrow | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": 60.95561899756811, "identifiers": [{"i": "UMLS:C1514058", "l": "Neoplastic Plasma Cell", "d": [], "t": []}, {"i": "NCIT:C37077", "l": "Neoplastic Plasma Cell", "d": ["A term that refers to a population of abnormal, clonal cells that originate from B-cells in the bone marrow and proliferate uncontrollably, leading to the formation of plasma cell neoplasms (multiple myeloma, plasmacytoma, and plasma cell leukemia)."], "t": []}], "preferred_name": "Neoplastic Plasma Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 85.53200374075534, "identifiers": [{"i": "CL:0011013", "l": "motile sperm cell", "d": ["A sperm cell that is cabaple of motion (motility)."], "t": []}, {"i": "UMLS:C0037868", "l": "sperm cell", "d": [], "t": []}, {"i": "NCIT:C12602", "l": "Spermatozoon", "d": ["The male reproductive cell that is formed in the testicle. A sperm consists of a head, a body, and a tail that provides propulsion."], "t": []}, {"i": "MESH:D013094", "l": "Spermatozoa", "d": [], "t": []}, {"i": "SNOMEDCT:6789008", "l": "", "d": [], "t": []}], "preferred_name": "motile sperm cell", "taxa": []}
{"type": "biolink:Cell", "ic": 73.85694246010084, "identifiers": [{"i": "CL:0002202", "l": "epithelial cell of tracheobronchial tree", "d": ["An epithelial cell of the tracheobronchial tree."], "t": []}, {"i": "UMLS:C1179829", "l": "Epithelial cell of tracheobronchial tree", "d": [], "t": []}], "preferred_name": "epithelial cell of tracheobronchial tree", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "UMLS:C1883044", "l": "Small Adenocarcinoma Cell with Scant Amount of Cytoplasm", "d": [], "t": []}, {"i": "NCIT:C61144", "l": "Small Adenocarcinoma Cell with Scant Amount of Cytoplasm", "d": [], "t": []}], "preferred_name": "Small Adenocarcinoma Cell with Scant Amount of Cytoplasm", "taxa": []}
{"type": "biolink:Cell", "ic": 67.8984399852903, "identifiers": [{"i": "CL:0000990", "l": "conventional dendritic cell", "d": ["Conventional dendritic cell is a dendritic cell that is CD11c-high."], "t": []}], "preferred_name": "conventional dendritic cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0011031", "l": "monocyte-derived dendritic cell", "d": ["A dendritic cell that develops from a monocyte."], "t": []}], "preferred_name": "monocyte-derived dendritic cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0000721", "l": "equatorial cone cell (sensu Endopterygota)", "d": [], "t": []}], "preferred_name": "equatorial cone cell (sensu Endopterygota)", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5707907", "l": "Firzotemcel", "d": [], "t": []}, {"i": "NCIT:C188605", "l": "Firzotemcel", "d": [], "t": []}], "preferred_name": "Firzotemcel", "taxa": []}
{"type": "biolink:Cell", "ic": 78.05853671694304, "identifiers": [{"i": "CL:0002465", "l": "CD11b-positive dendritic cell", "d": ["A conventional dendritic cell that expresses CD11b (ITGAM)."], "t": []}], "preferred_name": "CD11b-positive dendritic cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4505192", "l": "THP-1 Cells", "d": [], "t": []}, {"i": "MESH:D000074084", "l": "THP-1 Cells", "d": [], "t": []}], "preferred_name": "THP-1 Cells", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5815493", "l": "Allogeneic Cardiosphere-Derived Cells", "d": [], "t": []}], "preferred_name": "Allogeneic Cardiosphere-Derived Cells", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1317561", "l": "Neutrophils.vacuolated+Segmented", "d": [], "t": []}], "preferred_name": "Neutrophils.vacuolated+Segmented", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5447112", "l": "Autologous Anti-GPRC5D-CAR-4-1BB-expressing T-cells MCARH109", "d": [], "t": []}, {"i": "NCIT:C176222", "l": "Autologous Anti-GPRC5D-CAR-4-1BB-expressing T-cells MCARH109", "d": ["A preparation of autologous T-lymphocytes that have been transduced with a retroviral vector expressing a chimeric antigen receptor (CAR) containing a single chain variable fragment (scFv) specific for the tumor-associated antigen (TAA) human G-protein coupled receptor family C group 5 member D (GPRC5D) and the co-stimulatory domain 4-1BB (CD137), with potential immunostimulating and antineoplastic activities. Upon leukapheresis, isolation, transduction, expansion ex vivo, and reintroduction into the patient, the autologous anti-GPRC5D-CAR-4-1BB-expressing T-cells MCARH109 specifically recognize and induce selective toxicity in GPRC5D-expressing tumor cells. GPRC5D is overexpressed in certain malignancies, such as multiple myeloma, while minimally expressed in normal, healthy cells. It plays a key role in tumor cell proliferation."], "t": []}], "preferred_name": "Autologous Anti-GPRC5D-CAR-4-1BB-expressing T-cells MCARH109", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C3830410", "l": "DNR-expressing Nasopharyngeal Carcinoma-specific Cytotoxic T-Lymphocytes", "d": [], "t": []}, {"i": "NCIT:C114378", "l": "DNR-expressing Nasopharyngeal Carcinoma-specific Cytotoxic T-Lymphocytes", "d": ["A preparation of autologous, dominant-negative receptor (DNR)-expressing nasopharyngeal carcinoma (NPC)-specific cytotoxic T-lymphocytes (CTLs), with potential antineoplastic activity. The DNR-expressing NPC-specific CTLs specifically target Epstein-Barr virus (EBV) nuclear antigen 1 (EBNA1), latent membrane proteins (LMP) and BamHIA rightward frame 1 (BARF1), and are transduced with a retroviral vector expressing DNR, a dominant-negative form of the transforming growth factor beta (TGFb) receptor, which blocks TGF-beta-mediated signaling. Upon administration, the CTLs recognize and target NPC cells, which may result in both CTL-mediated cell lysis and the inhibition of tumor cell proliferation. Tumor-expressed TGF-beta inhibits T-lymphocyte activation and expansion; resistance to TGF-beta allows for optimal CTL activity. EBV infection plays a key role in NPC tumorigenesis."], "t": []}], "preferred_name": "DNR-expressing Nasopharyngeal Carcinoma-specific Cytotoxic T-Lymphocytes", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5157558", "l": "CD4+HLA-DR+ cells | Blood | Cell markers", "d": [], "t": []}], "preferred_name": "CD4+HLA-DR+ cells | Blood | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1510963", "l": "Atypical Reparative Cell", "d": [], "t": []}, {"i": "NCIT:C36785", "l": "Atypical Reparative Cell", "d": [], "t": []}], "preferred_name": "Atypical Reparative Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0002588", "l": "smooth muscle cell of the umbilical vein", "d": ["A smooth muscle cell of the umbilical vein."], "t": []}], "preferred_name": "smooth muscle cell of the umbilical vein", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C2340402", "l": "Intrafascicular oligodendrocyte", "d": [], "t": []}], "preferred_name": "Intrafascicular oligodendrocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 92.76600187037766, "identifiers": [{"i": "UMLS:C1512551", "l": "Hyperchromatic Stromal Cell", "d": [], "t": []}, {"i": "NCIT:C36980", "l": "Hyperchromatic Stromal Cell", "d": [], "t": []}], "preferred_name": "Hyperchromatic Stromal Cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5426956", "l": "Epithelial cells | Prostatic fluid | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Epithelial cells | Prostatic fluid | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": 92.76600187037766, "identifiers": [{"i": "CL:0000588", "l": "odontoclast", "d": ["A specialized osteoclast associated with the absorption and removal of cementum."], "t": []}], "preferred_name": "odontoclast", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5177616", "l": "Platelets | Blood capillary | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Platelets | Blood capillary | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": 70.90339783960249, "identifiers": [{"i": "CL:0000160", "l": "goblet cell", "d": ["A specialized, columnar, mucus secreting epithelial cell shaped like a flask or goblet. A narrow basal end contains the nucleus while the apical end is swollen by the accumulation of mucus laden secretory granules.  Short microvilli project from the apical plasma membrane."], "t": []}, {"i": "UMLS:C0506994", "l": "Goblet Cells", "d": [], "t": []}, {"i": "NCIT:C12586", "l": "Goblet Cell", "d": ["A mucin-producing and -secreting epithelial cell found mainly in the intestinal and respiratory tracts."], "t": []}, {"i": "MESH:D020397", "l": "Goblet Cells", "d": [], "t": []}], "preferred_name": "goblet cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4079013", "l": "lumbar dorsal root ganglion Nav1.7 neuron", "d": ["A nociceptor whose soma is located in the lumbar dorsal root ganglion and that expresses the voltage-gated sodium channel Nav1.7 (encoded by SCN9A). This neuron is characterized by Nav1.7-dependent action potential initiation and amplification, which is essential for normal pain sensation in humans. Nav1.7 contributes approximately 50% of total sodium channel current in human DRG nociceptors (Chang et al. 2018, PMID:28424991). In human DRG, Nav1.7 immunoreactivity is detected in 54-57% of TrkA-positive neurons (Rostock et al. 2018, PMID:29229553). Human genetic evidence confirms Nav1.7 as necessary and sufficient for nociceptive function in these neurons."], "t": []}], "preferred_name": "lumbar dorsal root ganglion Nav1.7 neuron", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5157273", "l": "CD11c+CD103+ cells | Blood | Cell markers", "d": [], "t": []}], "preferred_name": "CD11c+CD103+ cells | Blood | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": 72.615132056446, "identifiers": [{"i": "CL:0000653", "l": "podocyte", "d": ["A specialized kidney epithelial cell, contained within a glomerulus, that contains \"feet\" that interdigitate with the \"feet\" of other podocytes."], "t": []}], "preferred_name": "podocyte", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1257792", "l": "Vascular Endothelial Cells", "d": [], "t": []}], "preferred_name": "Vascular Endothelial Cells", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5977366", "l": "CD3-CD14-CD19+CD45+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:1373220008", "l": "", "d": [], "t": []}], "preferred_name": "CD3-CD14-CD19+CD45+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": 78.29800561113302, "identifiers": [{"i": "CL:0000441", "l": "follicle stem cell (sensu Arthropoda)", "d": ["A stem cell that gives rise to the follicle cells that surround the oocyte in female arthropods."], "t": []}], "preferred_name": "follicle stem cell (sensu Arthropoda)", "taxa": []}
{"type": "biolink:Cell", "ic": 88.20185721311867, "identifiers": [{"i": "UMLS:C1517539", "l": "Giant Adenocarcinoma Cell", "d": [], "t": []}, {"i": "NCIT:C36857", "l": "Giant Adenocarcinoma Cell", "d": [], "t": []}], "preferred_name": "Giant Adenocarcinoma Cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C2350246", "l": "Monocyte-Macrophage Precursor Cells", "d": [], "t": []}, {"i": "MESH:D055017", "l": "Monocyte-Macrophage Precursor Cells", "d": [], "t": []}], "preferred_name": "Monocyte-Macrophage Precursor Cells", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1651663", "l": "CD20+CD23+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:1372993000", "l": "", "d": [], "t": []}], "preferred_name": "CD20+CD23+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C2331711", "l": "Blue cone bipolar cell", "d": [], "t": []}], "preferred_name": "Blue cone bipolar cell", "taxa": []}
{"type": "biolink:Cell", "ic": 88.20185721311867, "identifiers": [{"i": "CL:0002083", "l": "type I cell of adrenal medulla", "d": ["A chromaffin cell of the adrenal medulla that produces norepinephrine."], "t": []}, {"i": "UMLS:C1181530", "l": "Type I cell of adrenal medulla", "d": [], "t": []}], "preferred_name": "type I cell of adrenal medulla", "taxa": []}
{"type": "biolink:Cell", "ic": 89.40238429118027, "identifiers": [{"i": "CL:0002210", "l": "red muscle cell", "d": ["A slow muscle cell that contains high levels of myoglobin and oxygen storing proteins giving the cell a red appearance."], "t": []}], "preferred_name": "red muscle cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:1000691", "l": "kidney interstitial myofibroblast", "d": [], "t": []}], "preferred_name": "kidney interstitial myofibroblast", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1267899", "l": "Lymphocyte positive for CD26 antigen", "d": [], "t": []}, {"i": "SNOMEDCT:117570001", "l": "", "d": [], "t": []}], "preferred_name": "Lymphocyte positive for CD26 antigen", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "CL:0005025", "l": "visceromotor neuron", "d": ["A motor neuron that synapses to parasympathetic neurons that innervate tear glands, sweat glands, and the smooth muscles and glands of the pulmonary, cardiovascular, and gastrointestinal systems."], "t": []}], "preferred_name": "visceromotor neuron", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0002029", "l": "Fc-epsilon RIalpha-low mast cell progenitor", "d": ["A lineage-negative, Kit-positive, CD45-positive mast cell progenitor that is Fc-epsilon RIalpha-low."], "t": []}], "preferred_name": "Fc-epsilon RIalpha-low mast cell progenitor", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5163711", "l": "Erythrocytes | Bone marrow | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Erythrocytes | Bone marrow | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C2347293", "l": "Mononucleated Blood Cell", "d": [], "t": []}, {"i": "NCIT:C73123", "l": "Mononucleated Blood Cell", "d": ["A mixture of cells possessing a single nucleus, including monocytes and lymphocytes; blood leukocytes from which granulocytes have been separated and removed."], "t": []}], "preferred_name": "Mononucleated Blood Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C0333842", "l": "Niemann-Pick cell", "d": [], "t": []}, {"i": "NCIT:C36844", "l": "Niemann-Pick Cell", "d": [], "t": []}, {"i": "SNOMEDCT:9240003", "l": "", "d": [], "t": []}], "preferred_name": "Niemann-Pick cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4510924", "l": "Blast cell positive for CD21 antigen", "d": [], "t": []}, {"i": "SNOMEDCT:725173000", "l": "", "d": [], "t": []}], "preferred_name": "Blast cell positive for CD21 antigen", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C4745325", "l": "ECT-001 expanded cord blood", "d": [], "t": []}, {"i": "NCIT:C156693", "l": "ECT-001 Expanded Cord Blood", "d": ["A preparation of umbilical cord blood (UCB) co-cultured and expanded in an optimized culture system with a small molecule agonist of hematopoietic stem cell (HSC) renewal, with potential use in hematopoietic cell transplantation (HCT). Upon administration, the ECT-001 expanded cord blood cells increase and restore the number of hematopoietic stem and progenitor cells (HSPCs) that can differentiate into a variety of cell types and promote blood cell recovery. Compared to untreated UBCs, ECT-001 expanded UCB cells may exhibit enhanced stem cell proliferation and engraftment."], "t": []}], "preferred_name": "ECT-001 expanded cord blood", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5908024", "l": "Autologous CRISPR-Cas9 Engineered Tumor Infiltrating Lymphocytes KSQ-001EX", "d": [], "t": []}, {"i": "NCIT:C204100", "l": "Autologous CRISPR-Cas9 Engineered Tumor Infiltrating Lymphocytes KSQ-001EX", "d": ["A preparation of autologous tumor infiltrating lymphocytes (TILs) gene-edited with the clustered regularly interspaced short palindromic repeats (CRISPR)-Cas9 nuclease complex to inactivate the endogenous gene suppressor of cytokine signaling 1 (SOCS1), with potential immunomodulating and antineoplastic activities. Upon infusion of the autologous CRISPR-Cas9 engineered TILs KSQ-001EX back into the patient, the cells specifically recognize, target and kill the patient's tumor cells. SOCS1 serves as a negative regulator of cytokine signaling in T-cells and negatively influences the survival, differentiation, and function of T-cells. Inactivation of endogenous SOCS1 in TILs increases responsiveness to cytokine signals, and enhances anti-tumor potency, persistence and memory formation of TILs."], "t": []}], "preferred_name": "Autologous CRISPR-Cas9 Engineered Tumor Infiltrating Lymphocytes KSQ-001EX", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0443611", "l": "Fat globule", "d": [], "t": []}, {"i": "SNOMEDCT:259580005", "l": "", "d": [], "t": []}], "preferred_name": "Fat globule", "taxa": []}
{"type": "biolink:Cell", "ic": 65.87967120196224, "identifiers": [{"i": "CL:0000335", "l": "mesenchyme condensation cell", "d": ["A mesenchymal cell in embryonic development found in a contracting mass and that gives rise to osteoprogenitors."], "t": []}], "preferred_name": "mesenchyme condensation cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5177629", "l": "Platelets reticulated | Blood | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Platelets reticulated | Blood | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1267803", "l": "FMC7+ lymphocyte", "d": [], "t": []}, {"i": "SNOMEDCT:117507002", "l": "", "d": [], "t": []}], "preferred_name": "FMC7+ lymphocyte", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0945924", "l": "CD23+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:116755006", "l": "", "d": [], "t": []}], "preferred_name": "CD23+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "UMLS:C1709223", "l": "Nevoid Polygonal Cell", "d": [], "t": []}, {"i": "NCIT:C54077", "l": "Nevoid Polygonal Cell", "d": [], "t": []}], "preferred_name": "Nevoid Polygonal Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 68.36711220989689, "identifiers": [{"i": "UMLS:C1514076", "l": "Neoplastic Round Cell", "d": [], "t": []}, {"i": "NCIT:C37099", "l": "Neoplastic Round Cell", "d": [], "t": []}], "preferred_name": "Neoplastic Round Cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1440301", "l": "CD37+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:1372875002", "l": "", "d": [], "t": []}], "preferred_name": "CD37+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0000854", "l": "interneuromast cell", "d": ["Interneuromast cell is a neuroectodermal cell deposited by the migrating lateral line primordium between the neuromasts. Interneuromast cells proliferate and migrate to form additional neuromasts."], "t": []}], "preferred_name": "interneuromast cell", "taxa": []}
{"type": "biolink:Cell", "ic": 92.76600187037766, "identifiers": [{"i": "CL:0009091", "l": "Leydig stem cell", "d": ["A stem cell found in the interstitial compartment of the neonatal testis; it is capable of self-renewal as well as differentiation into steroidogenic cells (adult Leydig cells). Intermediate stages of development include progenitor Leydig cells and immature Leydig cells."], "t": []}], "preferred_name": "Leydig stem cell", "taxa": []}
{"type": "biolink:Cell", "ic": 90.871710685482, "identifiers": [{"i": "CL:0000482", "l": "juvenile hormone secreting cell", "d": ["An endocrine cell that secretes juvenile hormone."], "t": []}], "preferred_name": "juvenile hormone secreting cell", "taxa": []}
{"type": "biolink:Cell", "ic": 62.31208739485893, "identifiers": [{"i": "CL:0011012", "l": "neural crest cell", "d": ["A cell of the neural crest. Neural crest cells are multipotent. Premigratory neural crest cells are found at the neural plate boarder, some of which will undergo ectomesynchymal transition and delamination to form migratory neural crest cells."], "t": []}], "preferred_name": "neural crest cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1115673", "l": "Lymphocytes.lambda", "d": [], "t": []}], "preferred_name": "Lymphocytes.lambda", "taxa": []}
{"type": "biolink:Cell", "ic": 86.30756602822301, "identifiers": [{"i": "UMLS:C5706883", "l": "SF1-Lineage Adenohypophysial Cell", "d": [], "t": []}, {"i": "NCIT:C187078", "l": "SF1-Lineage Adenohypophysial Cell", "d": ["An adenohypophysial cell determined by the expression of the transcription factor SF1."], "t": []}], "preferred_name": "SF1-Lineage Adenohypophysial Cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C2717773", "l": "Gametophytes", "d": [], "t": []}], "preferred_name": "Gametophytes", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5909013", "l": "Dorocubicel", "d": [], "t": []}, {"i": "NCIT:C203130", "l": "Dorocubicel", "d": [], "t": []}], "preferred_name": "Dorocubicel", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5216292", "l": "Neutrophils|NCnc|Pt|CSF", "d": [], "t": []}], "preferred_name": "Neutrophils|NCnc|Pt|CSF", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0002021", "l": "GlyA-positive erythrocyte", "d": ["An enucleate erythrocyte that is GlyA-positive."], "t": []}], "preferred_name": "GlyA-positive erythrocyte", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0301868", "l": "Committed cell", "d": [], "t": []}, {"i": "SNOMEDCT:55484008", "l": "", "d": [], "t": []}], "preferred_name": "Committed cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5184272", "l": "Tubular cells | Urine sediment | Urinalysis", "d": [], "t": []}], "preferred_name": "Tubular cells | Urine sediment | Urinalysis", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5168976", "l": "Immature basophils | Blood | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Immature basophils | Blood | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": 90.871710685482, "identifiers": [{"i": "CL:0002619", "l": "adult endothelial progenitor cell", "d": ["An adult angioblastic cell released from the bone marrow, or from the kidney in some teleost species, capable of blood circulation and participation in angiogenesis by differentiating into blood vessel endothelial cells."], "t": []}], "preferred_name": "adult endothelial progenitor cell", "taxa": []}
{"type": "biolink:Cell", "ic": 87.18682603146104, "identifiers": [{"i": "CL:0002075", "l": "brush cell of tracheobronchial tree", "d": ["A rare type of columnar epithelial cell that is part of the tracheobronchial epithelium. This cell is characterized by a distinctive tuft of apical microvilli, which extends into the cytoplasm, and a pear-shaped morphology, broad at the base and tapering to a narrow apex. It plays vital roles in chemosensation, producing cytokines like IL-25, and enhancing mucociliary clearance through acetylcholine release to support mucus movement and airway defense."], "t": []}], "preferred_name": "brush cell of tracheobronchial tree", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5155170", "l": "Blasts | Peritoneal fluid | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Blasts | Peritoneal fluid | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5157260", "l": "CD117 blasts | Blood | Cell markers", "d": [], "t": []}], "preferred_name": "CD117 blasts | Blood | Cell markers", "taxa": []}
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{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1955314", "l": "Leukemia markers", "d": [], "t": []}], "preferred_name": "Leukemia markers", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5172503", "l": "Mesothelial cells | Body fluid | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Mesothelial cells | Body fluid | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": 72.4125108737624, "identifiers": [{"i": "CL:1000504", "l": "kidney medulla cell", "d": ["A cell that is part of a renal medulla."], "t": []}], "preferred_name": "kidney medulla cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5174120", "l": "Myeloperoxidase cells | Body fluid | Cell markers", "d": [], "t": []}], "preferred_name": "Myeloperoxidase cells | Body fluid | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C2964437", "l": "Pseudo Pelger Huet cells", "d": [], "t": []}], "preferred_name": "Pseudo Pelger Huet cells", "taxa": []}
{"type": "biolink:Cell", "ic": 39.93860233790366, "identifiers": [{"i": "UMLS:C1513942", "l": "Neoplastic Connective and Soft Tissue Cell", "d": [], "t": []}, {"i": "NCIT:C36887", "l": "Neoplastic Connective and Soft Tissue Cell", "d": [], "t": []}], "preferred_name": "Neoplastic Connective and Soft Tissue Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 86.30756602822301, "identifiers": [{"i": "CL:0002069", "l": "type II vestibular sensory cell", "d": ["Mostly cylindrical, resemble Type 1 in their contents and the presence of a kinocilium and stereocilium apically; much greater variation in size, some almost span the entire thickness of the sensory epithelium, while others are smaller than Type 1; receive multiple efferent nerve boutons around their bases as well as afferent endings, which are small expansions rather than chalices."], "t": []}, {"i": "UMLS:C0206513", "l": "Type 2 vestibular sensory cell", "d": [], "t": []}, {"i": "NCIT:C12631", "l": "Type II Hair Cell", "d": ["A cylinder-shaped mechanoreceptor cell that detects and transduces head movements into neural impulses and is located within the vestibular systems of all vertebrates."], "t": []}, {"i": "SNOMEDCT:17012008", "l": "", "d": [], "t": []}], "preferred_name": "type II vestibular sensory cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1517530", "l": "Mouse Germ Cell", "d": [], "t": []}, {"i": "NCIT:C24193", "l": "Mouse Germ Cell", "d": [], "t": []}], "preferred_name": "Mouse Germ Cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0682551", "l": "Argyrophilic cell", "d": [], "t": []}], "preferred_name": "Argyrophilic cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5171866", "l": "Macrophages | Fetus | Pleural fluid | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Macrophages | Fetus | Pleural fluid | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": 81.743421370964, "identifiers": [{"i": "CL:0000317", "l": "sebocyte", "d": ["An epithelial cell that is part of a sebaceous gland. This cell produces and secretes sebum, an oily, lipid-rich substance, through holocrine secretion where the entire cell ruptures to release its contents."], "t": []}], "preferred_name": "sebocyte", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1440242", "l": "CD115+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:1372823006", "l": "", "d": [], "t": []}], "preferred_name": "CD115+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0009031", "l": "T cell of appendix", "d": ["A T cell that is located in a vermiform appendix."], "t": []}], "preferred_name": "T cell of appendix", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1267861", "l": "Lymphoblast positive for CD10 antigen", "d": [], "t": []}, {"i": "SNOMEDCT:117543008", "l": "", "d": [], "t": []}], "preferred_name": "Lymphoblast positive for CD10 antigen", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4484160", "l": "FMR1+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:1373149005", "l": "", "d": [], "t": []}], "preferred_name": "FMR1+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:1001123", "l": "kidney outer medulla peritubular capillary cell", "d": ["An endothelial cell that is part of the peritubular capillary of the outer renal medulla."], "t": []}], "preferred_name": "kidney outer medulla peritubular capillary cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5216318", "l": "Reticulocytes|NCnc|Pt|Bld", "d": [], "t": []}], "preferred_name": "Reticulocytes|NCnc|Pt|Bld", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C3495990", "l": "Acg cell group", "d": [], "t": []}], "preferred_name": "Acg cell group", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5172358", "l": "Megakaryocytes | Bone marrow | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Megakaryocytes | Bone marrow | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C4684971", "l": "Allogeneic Nicotinamide-expanded Natural Killer Cells", "d": [], "t": []}, {"i": "NCIT:C143157", "l": "Allogeneic Nicotinamide-expanded Natural Killer Cells", "d": ["Allogeneic, nicotinamide (NAM)-expanded natural killer (NK) cells, with potential cytolytic and antineoplastic activities. Upon administration, the allogeneic NAM-expanded NK cells may lyse cancer cells. These cells also secrete pro-inflammatory cytokines, which further stimulate an anti-tumor immune response. Ex-vivo treatment with the vitamin B3 derivative NAM increases the in-vivo homing, retention and proliferation potential of the NK cells."], "t": []}], "preferred_name": "Allogeneic Nicotinamide-expanded Natural Killer Cells", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0314585", "l": "Diffusion chamber colony-forming unit", "d": [], "t": []}, {"i": "SNOMEDCT:445324003", "l": "", "d": [], "t": []}], "preferred_name": "Diffusion chamber colony-forming unit", "taxa": []}
{"type": "biolink:Cell", "ic": 62.66571162994402, "identifiers": [{"i": "UMLS:C1514109", "l": "Neoplastic T-Lymphocyte", "d": [], "t": []}, {"i": "NCIT:C38641", "l": "Neoplastic T-Lymphocyte", "d": [], "t": []}], "preferred_name": "Neoplastic T-Lymphocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "CL:4052015", "l": "endocrine gland capillary endothelial cell", "d": ["Any capillary endothelial cell that is part of an endocrine gland."], "t": []}], "preferred_name": "endocrine gland capillary endothelial cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C3495992", "l": "C3 adrenaline cells", "d": [], "t": []}], "preferred_name": "C3 adrenaline cells", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C3899624", "l": "Circulating Adipose Stromal Cell", "d": [], "t": []}, {"i": "NCIT:C116009", "l": "Circulating Adipose Stromal Cell", "d": ["A precursor of fat-storing cells, which is located in the blood circulation. Detection of these cells is associated with obesity and elevated risk for obesity-related neoplastic diseases such as breast, colon and prostate carcinomas."], "t": []}], "preferred_name": "Circulating Adipose Stromal Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1517738", "l": "Large Round Epithelioid Endothelial Cell", "d": [], "t": []}, {"i": "NCIT:C37094", "l": "Large Round Epithelioid Endothelial Cell", "d": [], "t": []}], "preferred_name": "Large Round Epithelioid Endothelial Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 80.27409497666227, "identifiers": [{"i": "CL:0002633", "l": "respiratory basal cell", "d": ["A basal cell in the respiratory tract."], "t": []}], "preferred_name": "respiratory basal cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0882860", "l": "CD4+CD25+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:1373106009", "l": "", "d": [], "t": []}], "preferred_name": "CD4+CD25+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5174624", "l": "Neutrophils | Stool | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Neutrophils | Stool | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C2325342", "l": "Set of cholinergic cells of substantia innominata [Ch4]", "d": [], "t": []}], "preferred_name": "Set of cholinergic cells of substantia innominata [Ch4]", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "UMLS:C1711304", "l": "Malignant Somatotroph Cell", "d": [], "t": []}, {"i": "NCIT:C45941", "l": "Malignant Somatotroph Cell", "d": [], "t": []}], "preferred_name": "Malignant Somatotroph Cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1267947", "l": "Lymphocyte positive for CD55 antigen", "d": [], "t": []}, {"i": "SNOMEDCT:117390009", "l": "", "d": [], "t": []}], "preferred_name": "Lymphocyte positive for CD55 antigen", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4033157", "l": "geniculate ganglion TRPV1 neuron", "d": ["A sensory neuron that has the soma located in the geniculate ganglion and expresses the marker transient receptor potential vanilloid 1 (TRPV1)."], "t": []}], "preferred_name": "geniculate ganglion TRPV1 neuron", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4322669", "l": "CD56+ NK lymphocyte", "d": [], "t": []}], "preferred_name": "CD56+ NK lymphocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 57.320960894191025, "identifiers": [{"i": "CL:0000362", "l": "epidermal cell", "d": ["An epithelial cell of the integument (the outer layer of an organism)."], "t": []}, {"i": "UMLS:C3496194", "l": "Epidermal cells", "d": [], "t": []}, {"i": "NCIT:C32271", "l": "Cell of the Epidermis", "d": ["An epithelial cell of the outer most layer of the skin."], "t": []}, {"i": "MESH:D000078404", "l": "Epidermal Cells", "d": [], "t": []}], "preferred_name": "epidermal cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:2000013", "l": "fibroblast of skin of abdomen", "d": ["Any skin fibroblast that is part of a skin of abdomen."], "t": []}], "preferred_name": "fibroblast of skin of abdomen", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C6024421", "l": "Helmet cell (cell)", "d": [], "t": []}, {"i": "SNOMEDCT:1382200006", "l": "", "d": [], "t": []}], "preferred_name": "Helmet cell (cell)", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C6008029", "l": "Oocyte of secondary follicle", "d": [], "t": []}, {"i": "SNOMEDCT:1351748003", "l": "", "d": [], "t": []}], "preferred_name": "Oocyte of secondary follicle", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5173468", "l": "Monocytes+Macrophages | Cerebral spinal fluid | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Monocytes+Macrophages | Cerebral spinal fluid | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": 80.96785908349635, "identifiers": [{"i": "CL:0001053", "l": "IgD-negative memory B cell", "d": ["A memory B cell that lacks expression of surface IgD."], "t": []}], "preferred_name": "IgD-negative memory B cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C4733678", "l": "Autologous Anti-mesothelin CAR-CD3zeta-4-1-BB-expressing T-cells", "d": [], "t": []}, {"i": "NCIT:C155909", "l": "Autologous Anti-mesothelin CAR-CD3zeta-4-1-BB-expressing T-cells", "d": ["A preparation of autologous T-lymphocytes transduced with a lentiviral vector expressing a chimeric antigen receptor (CAR) consisting of an anti-mesothelin M5 single chain variable fragment (scFv) fused to the costimulatory domains of 4-1BB (CD137) and the zeta chain of the TCR/CD3 complex (TCRzeta; CD247; CD3zeta), with potential immunomodulating and antineoplastic activities. After isolation, transduction, expansion in culture and reintroduction into the patient, the autologous anti-mesothelin CAR-CD3zeta-4-1BB-expressing T-cells specifically target and induce selective toxicity in mesothelin-expressing tumor cells. Mesothelin, a cell surface glycoprotein involved in cell adhesion, is overexpressed in a variety of cancer cell types."], "t": []}], "preferred_name": "Autologous Anti-mesothelin CAR-CD3zeta-4-1-BB-expressing T-cells", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5984662", "l": "Autologous NY-ESO-1/LAGE-1a-specific HLA-A*02:01-restricted TCR-expressing T-lymphocytes MDG1015", "d": [], "t": []}, {"i": "NCIT:C213073", "l": "Autologous NY-ESO-1/LAGE-1a-specific HLA-A*02:01-restricted TCR-expressing T-lymphocytes MDG1015", "d": ["A preparation of autologous T-lymphocytes that have been genetically engineered to express a T-cell receptor (TCR) specific for the human leukocyte antigen (HLA)-A*02:01-restricted cancer-testis antigens (CTAs) NY-ESO-1 and L antigen family member 1 isoform A (LAGE-1A; LAGE-A1; CT6.2a), and a programmed cell death protein 1 (PD-1; PDCD1; CD279)-4-1BB (CD137; tumor necrosis factor receptor superfamily member 9; TNFRSF9) costimulatory switch protein (CSP), with potential immunomodulating and antineoplastic activities. Upon reintroduction into the patient, autologous NY-ESO-1/LAGE-1a-specific HLA-A*02:01-restricted TCR-expressing T-lymphocytes MDG1015 specifically targets and binds to NY-ESO-1 and/or LAGE-1A expressed on tumor cells. This may lead to cytotoxic T-lymphocyte (CTL)-mediated elimination of tumor cells expressing NY-ESO-1 and/or LAGE-1A. In addition, upon binding of the TCR-T cells MDG1015 to NY-ESO-1 and/or LAGE-1A expressed on tumor cells, the PD-1-4-1BB CSP is activated. This abrogates PD-1-mediated signaling in T-cells and PD-1-mediated T-cell inhibition, and activates 4-1BB signaling locally in the tumor microenvironment (TME), which enhances the activity and persistence of the TCR-T cells MDG1015. NY-ESO-1 and LAGE-1A, members of the CTA family, are overexpressed on the surface of various tumor cell types; they share a specific HLA-A*02:01 epitope, 157-165, which is expressed on certain tumor cell types while its expression is not found on normal, healthy cells."], "t": []}], "preferred_name": "Autologous NY-ESO-1/LAGE-1a-specific HLA-A*02:01-restricted TCR-expressing T-lymphocytes MDG1015", "taxa": []}
{"type": "biolink:Cell", "ic": 72.11981073685999, "identifiers": [{"i": "CL:0000244", "l": "transitional epithelial cell", "d": ["A cell characteristically found lining hollow organs that are subject to great mechanical change due to contraction and distention; originally thought to represent a transition between stratified squamous and columnar epithelium."], "t": []}], "preferred_name": "transitional epithelial cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5853593", "l": "Autologous pancreatic islets", "d": [], "t": []}], "preferred_name": "Autologous pancreatic islets", "taxa": []}
{"type": "biolink:Cell", "ic": 68.47595218978095, "identifiers": [{"i": "CL:0000817", "l": "precursor B cell", "d": ["A precursor B cell is a B cell with the phenotype CD10-positive."], "t": []}], "preferred_name": "precursor B cell", "taxa": []}
{"type": "biolink:Cell", "ic": 90.871710685482, "identifiers": [{"i": "CL:0000922", "l": "type II NK T cell", "d": ["An alpha-beta T cell expressing NK call markers that is CD1d restricted and expresses a diverse TCR repertoire. Type II NKT cells do not become activated by alpha-galactosylceramide when presented by CD1d."], "t": []}], "preferred_name": "type II NK T cell", "taxa": []}
{"type": "biolink:Cell", "ic": 84.83823963392128, "identifiers": [{"i": "UMLS:C1711279", "l": "Neoplastic Parathyroid Gland Oncocyte", "d": [], "t": []}, {"i": "NCIT:C48272", "l": "Neoplastic Parathyroid Gland Oncocyte", "d": [], "t": []}], "preferred_name": "Neoplastic Parathyroid Gland Oncocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 85.53200374075534, "identifiers": [{"i": "CL:0000959", "l": "T2 B cell", "d": ["A transitional stage B cell that has the phenotype surface IgM-positive, surface IgD-postive, CD21-positive, CD23-positive, CD62L-negative, CD93-positive and is located in the splenic B follicles. This cell type has also been described as IgM-high, CD19-positive, B220-positive, AA4-positive, and CD23-positive."], "t": []}], "preferred_name": "T2 B cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0682550", "l": "silver-staining cell", "d": [], "t": []}], "preferred_name": "silver-staining cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1441143", "l": "Reticulocytes.mid", "d": [], "t": []}], "preferred_name": "Reticulocytes.mid", "taxa": []}
{"type": "biolink:Cell", "ic": 79.64650900338474, "identifiers": [{"i": "UMLS:C1707879", "l": "Eccrine Cell", "d": [], "t": []}, {"i": "NCIT:C43373", "l": "Eccrine Cell", "d": ["A secretory cell that discharges its product without loss of cytoplasm."], "t": []}], "preferred_name": "Eccrine Cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0747205", "l": "PANCYTOSIS", "d": [], "t": []}], "preferred_name": "PANCYTOSIS", "taxa": []}
{"type": "biolink:Cell", "ic": 88.20185721311867, "identifiers": [{"i": "UMLS:C1709182", "l": "Neoplastic Large Striated Muscle Cell with Clear Cytoplasm", "d": [], "t": []}, {"i": "NCIT:C49169", "l": "Neoplastic Large Striated Muscle Cell with Clear Cytoplasm", "d": [], "t": []}], "preferred_name": "Neoplastic Large Striated Muscle Cell with Clear Cytoplasm", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1518043", "l": "Lutzner Cell", "d": [], "t": []}, {"i": "NCIT:C39648", "l": "Lutzner Cell", "d": [], "t": []}], "preferred_name": "Lutzner Cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C3496266", "l": "B3 cell group", "d": [], "t": []}], "preferred_name": "B3 cell group", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0000591", "l": "warmth sensing thermoreceptor cell", "d": ["A thermoreceptor cell that detects increased temperatures."], "t": []}], "preferred_name": "warmth sensing thermoreceptor cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C2697995", "l": "MultiStem", "d": [], "t": []}], "preferred_name": "MultiStem", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5216297", "l": "Nucleated cells|NCnc|Pt|Body fld", "d": [], "t": []}], "preferred_name": "Nucleated cells|NCnc|Pt|Body fld", "taxa": []}
{"type": "biolink:Cell", "ic": 92.76600187037766, "identifiers": [{"i": "CL:4042017", "l": "alpha1-tanycyte", "d": ["The dorsal-most tanycyte type of the third venticle.  These cells projects into the ventromedial or dorsomedial nucleus of the hypothalamus. This type of tanycyte extends its protrusions close to parenchymal neurons without contacting blood vessels. It expresses the glial marker S-100β."], "t": []}], "preferred_name": "alpha1-tanycyte", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0002217", "l": "intermediate trophoblast cell", "d": ["A trophoblast that leaves the placenta and invades the endometrium and myometrium. This cell type is crucial in increasing blood flow to the fetus."], "t": []}, {"i": "UMLS:C1512865", "l": "Intermediate Type Trophoblastic Cell", "d": [], "t": []}, {"i": "NCIT:C33920", "l": "Intermediate Type Trophoblastic Cell", "d": ["A trophoblast that travels into the junctional zone of the decidua, reacting with maternal tissue leukocytes, mainly NK cells, macrophages and T cells, and invades maternal blood vessels feeding the placenta, softening the walls and replacing the lining with fetal tissue.  This junctional zone extends at the edge of the placenta to the amino-chorionic membranes where the chorionic laeve trophoblast has intimate contact with decidua tissue.  One of the primary functions of this cell is in implantation and in the establishment of the uteroplacental circulation since it extensively invades the spiral arteries at the placental site."], "t": []}], "preferred_name": "intermediate trophoblast cell", "taxa": []}
{"type": "biolink:Cell", "ic": 84.21065366064373, "identifiers": [{"i": "CL:0002405", "l": "gamma-delta thymocyte", "d": ["A post-natal thymocyte expressing components of the gamma-delta T cell receptor. This cell type is always double-negative (i.e. CD4-negative, CD8-negative)."], "t": []}], "preferred_name": "gamma-delta thymocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "CL:0000372", "l": "tormogen cell", "d": ["An epidermal cell that is part of a cell cluster organ of the insect integument (such as a sensillum) and that secretes a cuticular specialization that forms a socket around the base of a cuticular specialization produced by a trichogen cell."], "t": []}], "preferred_name": "tormogen cell", "taxa": []}
{"type": "biolink:Cell", "ic": 71.65915659676573, "identifiers": [{"i": "UMLS:C1512084", "l": "Ductal Carcinoma Cell", "d": [], "t": []}, {"i": "NCIT:C36858", "l": "Ductal Carcinoma Cell", "d": [], "t": []}], "preferred_name": "Ductal Carcinoma Cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5572242", "l": "Leukocytes | Bronchoalveolar lavage | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Leukocytes | Bronchoalveolar lavage | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1522158", "l": "Mouse Myeloblast", "d": [], "t": []}, {"i": "NCIT:C22589", "l": "Mouse Myeloblast", "d": [], "t": []}], "preferred_name": "Mouse Myeloblast", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5401387", "l": "Autologous Blinatumomab-expanded T-Cells", "d": [], "t": []}, {"i": "NCIT:C170899", "l": "Autologous Blinatumomab-expanded T-Cells", "d": ["A preparation of autologous, peripheral blood-derived polyclonal activated T-cells that have been expanded and activated ex-vivo using blinatumomab and recombinant human IL2 (rhIL-2) and depleted of contaminating CD19+ tumor cells, with potential immunomodulating activity. Upon administration, these blinatumomab-expanded T-cells (BET), composed of functional polyclonal CD4+ and CD8+ T-cells and mostly effector and central memory cells, may induce immunological recovery. BET cell expansion leads to the lysis and elimination of contaminating CD19+ tumor cells. The elimination of contaminating tumor cells is important in the treatment of non-Hodgkin CD20 + indolent lymphoma (iNHL) and chronic lymphatic leukemia (CLL)."], "t": []}], "preferred_name": "Autologous Blinatumomab-expanded T-Cells", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0599415", "l": "Spodoptera frugiperda cell line", "d": [], "t": []}], "preferred_name": "Spodoptera frugiperda cell line", "taxa": []}
{"type": "biolink:Cell", "ic": 63.88442841256432, "identifiers": [{"i": "CL:0000094", "l": "granulocyte", "d": ["A leukocyte with abundant granules in the cytoplasm."], "t": []}, {"i": "UMLS:C0018183", "l": "granulocyte", "d": [], "t": []}, {"i": "NCIT:C12530", "l": "Granulocyte", "d": ["A type of leukocyte with a multilobed nucleus and cytoplasmic granules. The unique morphology of the nucleus has led to their also being known as polymorphonuclear leukocytes (PMLs or PMNs). Granulocytes are subdivided according to the staining properties of their granules into eosinophils (red with acidic dye), basophils (blue with basic dye), and neutrophils (not amenable to staining with either acidic or basic dyes)."], "t": []}, {"i": "MESH:D006098", "l": "Granulocytes", "d": [], "t": []}, {"i": "SNOMEDCT:48791004", "l": "", "d": [], "t": []}], "preferred_name": "granulocyte", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1979637", "l": "Blasts.CD16", "d": [], "t": []}], "preferred_name": "Blasts.CD16", "taxa": []}
{"type": "biolink:Cell", "ic": 74.24062392510156, "identifiers": [{"i": "CL:0002315", "l": "supporting cell of cochlea", "d": ["An epithelial supporting cell located in the cochlea."], "t": []}, {"i": "UMLS:C2339402", "l": "Supporting cell of cochlea", "d": [], "t": []}], "preferred_name": "supporting cell of cochlea", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C3831170", "l": "CD138CAR-CD137/TCRzeta-expressing T Lymphocytes", "d": [], "t": []}, {"i": "NCIT:C107505", "l": "CD138CAR-CD137/TCRzeta-expressing T Lymphocytes", "d": ["T-lymphocytes transduced with a retroviral vector expressing a chimeric antigen receptor (CAR) specific for syndecan-1 (CD138) (CART-138 T cells) coupled to the signaling domain of 4-1BB (CD137), and the zeta chain of the T-cell receptor (TCRzeta), with potential immunomodulating and antineoplastic activities. Upon transfusion, CD138CAR- CD137/TCRzeta -expressing T lymphocytes directs the T-lymphocytes to syndecan-1-expressing tumor cells and induces selective toxicity in those tumor cells. The 4-1BB co-stimulatory molecule signaling domain enhances activation and signaling after recognition of syndecan-1. Syndecan-1, a type 1 transmembrane proteoglycan and tumor associated antigen, is overexpressed in a variety of cancer cells. It plays a key role in the regulation of cell growth, differentiation, and adhesion, and its expression is correlated with poor prognosis."], "t": []}], "preferred_name": "CD138CAR-CD137/TCRzeta-expressing T Lymphocytes", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4042004", "l": "choroid epiplexus macrophage", "d": ["A choroid plexus macrophage that is part of the apical surface of some choroid plexus epithelium. This macrophage has a star-like shaped body."], "t": []}], "preferred_name": "choroid epiplexus macrophage", "taxa": []}
{"type": "biolink:Cell", "ic": 69.67647926784257, "identifiers": [{"i": "UMLS:C1514092", "l": "Neoplastic Small Round Cell", "d": [], "t": []}, {"i": "NCIT:C37100", "l": "Neoplastic Small Round Cell", "d": [], "t": []}], "preferred_name": "Neoplastic Small Round Cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0018043", "l": "Golgi-Mazzoni Corpuscles", "d": [], "t": []}, {"i": "MESH:D006057", "l": "Golgi-Mazzoni Corpuscles", "d": [], "t": []}, {"i": "SNOMEDCT:37419002", "l": "", "d": [], "t": []}], "preferred_name": "Golgi-Mazzoni Corpuscles", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1440392", "l": "Cells.multiple drug resistance", "d": [], "t": []}], "preferred_name": "Cells.multiple drug resistance", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1449623", "l": "Neuroepithelial Bodies", "d": [], "t": []}, {"i": "MESH:D046568", "l": "Neuroepithelial Bodies", "d": [], "t": []}], "preferred_name": "Neuroepithelial Bodies", "taxa": []}
{"type": "biolink:Cell", "ic": 76.22330125402472, "identifiers": [{"i": "CL:0000657", "l": "secondary spermatocyte", "d": ["One of the two haploid cells into which a primary spermatocyte divides, and which in turn gives origin to spermatids."], "t": []}], "preferred_name": "secondary spermatocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C4764314", "l": "Ilixadencel", "d": [], "t": []}, {"i": "NCIT:C99902", "l": "Ilixadencel", "d": ["An off-the-shelf immune primer consisting of allogeneic monocyte-derived dendritic cells (MoDCs) that have been stimulated with a combination of activating factors to produce pro-inflammatory factors including tumor necrosis factor-alpha (TNF-alpha), interleukin-1 beta (IL-1 beta), interleukin-12, p70 (IL-12 p70), C-C motif chemokine 4 (CCL4; macrophage inflammatory protein 1-beta; MIP-1-beta), C-C motif chemokine 5 (CCL5; RANTES), and C-X-C motif chemokine 10 (CXCL10), with potential immunostimulating and antineoplastic activities. Upon intratumoral injection of ilixadencel, the dendritic cells (DCs) release type 1 T-helper cell (Th1)-associated chemokines, including CCL4, CCL5 and CXCL10, that may recruit natural killer (NK)-cells and pre-DCs into the tumor microenvironment (TME). The interaction between NK cells and ilixadencel DCs may induce NK-cell-mediated killing of tumor cells, resulting in release of tumor-associated-antigens (TAAs). The production of interferon-gamma (IFN-gamma) by activated NK-cells and TNF-alpha/beta released by ilixadencel DCs will induce maturation and promote cross-presentation of TAAs by recruited endogenous \"bystander\" DCs. Migration of these antigen-loaded and matured \"bystander\" DCs to the tumor-draining lymph node will lead to a Th1-polarized activation of tumor-specific T-cells."], "t": []}], "preferred_name": "Ilixadencel", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5216274", "l": "Monocytes|NCnc|Pt|CSF", "d": [], "t": []}], "preferred_name": "Monocytes|NCnc|Pt|CSF", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1513067", "l": "Neoplastic Medium-Sized Lymphocyte with Pale Cytoplasm", "d": [], "t": []}, {"i": "NCIT:C37007", "l": "Neoplastic Medium-Sized Lymphocyte with Pale Cytoplasm", "d": [], "t": []}], "preferred_name": "Neoplastic Medium-Sized Lymphocyte with Pale Cytoplasm", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4079029", "l": "thoracic dorsal root ganglion CGRP neuron", "d": ["A peptidergic nociceptor whose soma is located in the thoracic dorsal root ganglion, characterized by expression of calcitonin gene-related peptide (CGRP, encoded by CALCA). This small- to medium-diameter neuron belongs to the TrkA-positive peptidergic subpopulation and typically co-expresses substance P. It innervates peripheral tissues including skin and viscera, where it mediates neurogenic inflammation and nociceptive signalling through release of CGRP from peripheral terminals during tissue injury (Haberberger et al. 2019, PMID:31293388). In human DRG, CGRP-immunoreactive neurons represent a substantial proportion of nociceptors, comparable to the pattern observed in rodents (Rostock et al. 2018, PMID:29229553)."], "t": []}], "preferred_name": "thoracic dorsal root ganglion CGRP neuron", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5417890", "l": "Autologous CD19 CAR-expressing CD4+/CD8+ T-cells MB-CART19.1", "d": [], "t": []}, {"i": "NCIT:C172103", "l": "Autologous CD19 CAR-expressing CD4+/CD8+ T-cells MB-CART19.1", "d": ["A preparation of CD4+ and CD8+ autologous T-lymphocytes transduced with the lentiviral vector pLTG1563 expressing a chimeric antigen receptor (CAR) specific for the tumor-associated antigen (TAA) CD19, with potential immunostimulating and antineoplastic activities. Upon intravenous administration, the autologous CD19 CAR-expressing CD4+/CD8+ T-cells MB-CART19.1 are directed to and induce selective toxicity in CD19-expressing tumor cells. CD19 antigen is a B-cell specific cell surface antigen expressed in all B-cell lineage malignancies."], "t": []}], "preferred_name": "Autologous CD19 CAR-expressing CD4+/CD8+ T-cells MB-CART19.1", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5154300", "l": "Band form neutrophils | Fetus | Blood | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Band form neutrophils | Fetus | Blood | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4033132", "l": "celiac ganglion SOM neuron", "d": ["A sympathetic neuron that has the soma located in the celiac ganglion and expresses the marker somatostatin (SOM)."], "t": []}], "preferred_name": "celiac ganglion SOM neuron", "taxa": []}
{"type": "biolink:Cell", "ic": 90.871710685482, "identifiers": [{"i": "CL:0009021", "l": "stromal cell of lamina propria of large intestine", "d": ["A stromal cell found in the lamina propria of the large intestine."], "t": []}], "preferred_name": "stromal cell of lamina propria of large intestine", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1563926", "l": "Th3 Cells", "d": [], "t": []}], "preferred_name": "Th3 Cells", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C4687588", "l": "NY-ESO-1 TCR/sr39TK Lentiviral Vector-transduced Autologous PBSCs", "d": [], "t": []}, {"i": "NCIT:C146940", "l": "NY-ESO-1 TCR/sr39TK Lentiviral Vector-transduced Autologous PBSCs", "d": ["Human autologous peripheral blood stem cells (PBSCs) transduced with a lentiviral vector (LV) encoding a T-cell receptor (TCR) specific for the cancer-testis antigen NY-ESO-1, and carrying the positron emission tomography (PET) reporter/suicide gene sr39TK, a mutant form of the herpes simplex virus type 1 thymidine kinase gene (HSV-1 TK), with potential immunostimulating and antineoplastic activities. Upon isolation, transduction, expansion ex vivo, and reintroduction into the patient, the NY-ESO-1 TCR/sr39TK LV-transduced autologous PBSCs recognize and bind to NY-ESO-1-overexpressing tumor cells. This may result in a specific cytotoxic T-lymphocyte (CTL)-mediated killing of NY-ESO-1-positive tumor cells. NY-ESO-1, a tumor-associated antigen (TAA), is found in normal testis and on the surface of various tumor cell types. The incorporation of sr39TK allows for the ganciclovir (GCV)-mediated cell killing of the gene-modified PBSCs if serious adverse effects occur. sr39TK converts the nucleoside prodrug GCV into GCV monophosphate (GCV-MP), which is in turn phosphorylated by cellular kinases to the cytotoxic nucleotide GCV-triphosphate (GCV-TP); the TP form competitively inhibits deoxyguanosine triphosphate (dGTP) incorporation into DNA and inhibits DNA synthesis, causing DNA damage and cell death in the sr39TK-expressing PBSCs. In addition, sr39TK allows for PET imaging of the gene-modified PBSCs upon subsequent administration of radio-labeled substrates, such as 9-(4-[18F]-fluoro-3-[hydroxymethyl]butyl)guanine ([18F]-FHBG). The monophosphorylation of [18 F]-FHBG is catalyzed by sr39TK; this promotes triphosphorylation and accumulation of [18F]-FHBG in the PBSCs, which allows in vivo imaging and tracking of the PBSCs upon PET. Compared to wild-type HSV-TK, the mutant form has increased prodrug phosphorylating capacity and enhances the cell killing by GCV."], "t": []}], "preferred_name": "NY-ESO-1 TCR/sr39TK Lentiviral Vector-transduced Autologous PBSCs", "taxa": []}
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{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5151403", "l": "Acanthocytes | Blood | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Acanthocytes | Blood | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": 71.06400748151069, "identifiers": [{"i": "UMLS:C1516089", "l": "Atypical Adipocyte", "d": [], "t": []}, {"i": "NCIT:C36977", "l": "Atypical Adipocyte", "d": [], "t": []}], "preferred_name": "Atypical Adipocyte", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5157554", "l": "CD4+CD45RO+ cells | Tissue and Smears | Cell markers", "d": [], "t": []}], "preferred_name": "CD4+CD45RO+ cells | Tissue and Smears | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5667010", "l": "Autologous Anti-mesothelin CAR-IL-7-CCL19-expressing T-lymphocytes TAK-103", "d": [], "t": []}], "preferred_name": "Autologous Anti-mesothelin CAR-IL-7-CCL19-expressing T-lymphocytes TAK-103", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0002356", "l": "primitive reticulocyte", "d": ["A primitive erythrocyte that has undergone enucleation. This cell type is 3-6 fold bigger than the fetal derived erythrocytes that they co-circulate with during fetal development. Expresses epsilon-gamma hemoglobin chains."], "t": []}], "preferred_name": "primitive reticulocyte", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C3494180", "l": "Bone Marrow Stromal Cells, Multipotent", "d": [], "t": []}], "preferred_name": "Bone Marrow Stromal Cells, Multipotent", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5157660", "l": "CD79a cells | Blood | Cell markers", "d": [], "t": []}], "preferred_name": "CD79a cells | Blood | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C6021832", "l": "T-helper 1", "d": [], "t": []}], "preferred_name": "T-helper 1", "taxa": []}
{"type": "biolink:Cell", "ic": 84.83823963392128, "identifiers": [{"i": "CL:0000394", "l": "plasmatocyte", "d": ["A phagocytic hemocyte, responsible for the engulfment of small particles, microbes, and apoptotic tissue debris. It may also secretes antimicrobial peptides and contribute to the production and secretion of proteins of the hemolymph."], "t": []}], "preferred_name": "plasmatocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0003039", "l": "M8 retinal ganglion cell", "d": ["A monostratified retinal ganglion cell with large soma and medium dendritic field, with dense dendritic arbor."], "t": []}], "preferred_name": "M8 retinal ganglion cell", "taxa": []}
{"type": "biolink:Cell", "ic": 71.31251504405601, "identifiers": [{"i": "UMLS:C1515275", "l": "Terminal Ductal Lobular Unit Cell", "d": [], "t": []}, {"i": "NCIT:C33756", "l": "Terminal Ductal Lobular Unit Cell", "d": ["An epithelial cell found in the small lobes at the end of the milk ducts inside the breast where the milk-producing cells are."], "t": []}], "preferred_name": "Terminal Ductal Lobular Unit Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4033028", "l": "diffuse bipolar 2 cell", "d": ["An OFF diffuse bipolar cell that predominantly connects to ON parasol cells and lateral amacrine cells. This cell contains a large number of synaptic ribbons and a small axon arbor area."], "t": []}], "preferred_name": "diffuse bipolar 2 cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1267894", "l": "Lymphocyte positive for both CD22 antigen and CD19 antigen", "d": [], "t": []}, {"i": "SNOMEDCT:117567000", "l": "", "d": [], "t": []}], "preferred_name": "Lymphocyte positive for both CD22 antigen and CD19 antigen", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0020052", "l": "stubby Dogiel type I neuron of myenteric plexus", "d": ["A Dogiel type I neuron of the myenteric plexus characterised by stubby (lamellar) dendrite morphology with broad, flattened dendritic expansions. This neuron is immunopositive for choline acetyltransferase (ChAT) and immunonegative for neuronal nitric oxide synthase (NOS1), corresponding to excitatory motor neurons of the enteric nervous system."], "t": []}], "preferred_name": "stubby Dogiel type I neuron of myenteric plexus", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C4727557", "l": "Allogeneic CD19CAR-transfected Cytokine-induced Killer Cells", "d": [], "t": []}, {"i": "NCIT:C154284", "l": "Allogeneic CD19CAR-transfected Cytokine-induced Killer Cells", "d": ["A preparation of allogeneic cytokine-induced killer (CIK) cells derived from peripheral blood mononuclear cells (PBMCs) transfected with the Sleeping Beauty (SB) transposon, CD19CAR (CARCIK-CD19), with potential immunomodulatory and antineoplastic activities. CIK cells are CD3- and CD56-positive, non-major histocompatibility complex (MHC)-restricted, natural killer (NK)-like T-lymphocytes. Upon infusion following an allogeneic stem cell transplantation, the CARCIK-CD19 cells bind to CD19-expressing tumor cells, thereby inducing selective toxicity in CD19-expressing tumor cells. CIK cells may have enhanced cytotoxic activity compared to lymphokine-activated killer (LAK) cells. CD19 is a B-cell specific cell surface antigen expressed in all B-cell lineage malignancies."], "t": []}], "preferred_name": "Allogeneic CD19CAR-transfected Cytokine-induced Killer Cells", "taxa": []}
{"type": "biolink:Cell", "ic": 42.92619722760468, "identifiers": [{"i": "CL:0000679", "l": "glutamatergic neuron", "d": ["A neuron that is capable of some neurotansmission by glutamate secretion."], "t": []}], "preferred_name": "glutamatergic neuron", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5173494", "l": "Mononuclear cells | Bone marrow | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Mononuclear cells | Bone marrow | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0598829", "l": "Madin Darby Canine Kidney Cells", "d": [], "t": []}, {"i": "MESH:D061985", "l": "Madin Darby Canine Kidney Cells", "d": [], "t": []}], "preferred_name": "Madin Darby Canine Kidney Cells", "taxa": []}
{"type": "biolink:Cell", "ic": 92.76600187037766, "identifiers": [{"i": "CL:0002272", "l": "motilin secreting cell", "d": ["A cell that secretes motilin, a gastric hormone that at low pH inhibits gastric motor activity, whereas at high pH has a stimulating effect."], "t": []}], "preferred_name": "motilin secreting cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0682690", "l": "primary sensory neuron", "d": [], "t": []}], "preferred_name": "primary sensory neuron", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1979510", "l": "Cells.CD11c+20c+", "d": [], "t": []}], "preferred_name": "Cells.CD11c+20c+", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4300402", "l": "Cells.chromosome region 5q31 deletion", "d": [], "t": []}], "preferred_name": "Cells.chromosome region 5q31 deletion", "taxa": []}
{"type": "biolink:Cell", "ic": 70.66959805369461, "identifiers": [{"i": "CL:0002453", "l": "oligodendrocyte precursor cell", "d": ["A proliferative and migratory glial progenitor cell that derives from a neural stem cell and resides within the central nervous system. It possesses the capacity to differentiate into a committed oligodendrocyte progenitor (COP) through a well-defined series of maturation steps, ultimately giving rise to a myelinating oligodendrocyte (MOL). In mice and humans, it is characterized by the expression of specific molecular markers, including Pdgfra, Cspg4 (also known as NG2) and Olig2."], "t": []}, {"i": "UMLS:C4505105", "l": "Oligodendrocyte Precursor Cells", "d": [], "t": []}, {"i": "MESH:D000073637", "l": "Oligodendrocyte Precursor Cells", "d": [], "t": []}], "preferred_name": "oligodendrocyte precursor cell", "taxa": []}
{"type": "biolink:Cell", "ic": 83.63771255585968, "identifiers": [{"i": "CL:0000186", "l": "myofibroblast cell", "d": ["An animal cell that has characteristics of both a fibroblast cell and a smooth muscle cell."], "t": []}, {"i": "UMLS:C0225360", "l": "Myofibroblasts", "d": [], "t": []}, {"i": "NCIT:C33153", "l": "Myofibroblast", "d": ["A spindle-shaped cell that exhibits characteristics of both fibroblasts and smooth muscle cells. It has an elongated nucleus and does not have basal lamina. The cytoplasm can be distinguished from the surrounding matrix because of actin filaments, myosin and other muscle proteins arranged to suggest a contractile ability."], "t": []}, {"i": "MESH:D058628", "l": "Myofibroblasts", "d": [], "t": []}, {"i": "SNOMEDCT:56790003", "l": "", "d": [], "t": []}], "preferred_name": "myofibroblast cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C2328179", "l": "Enteric ganglion neuron", "d": [], "t": []}], "preferred_name": "Enteric ganglion neuron", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:1000477", "l": "cardiac pacemaker cell of sinoatrial node", "d": ["A nodal myocyte that is part of the sinoatrial node."], "t": []}, {"i": "UMLS:C2328498", "l": "Pacemaker cell of sinuatrial node", "d": [], "t": []}], "preferred_name": "cardiac pacemaker cell of sinoatrial node", "taxa": []}
{"type": "biolink:Cell", "ic": 45.82017979457059, "identifiers": [{"i": "UMLS:C1513973", "l": "Neoplastic Glandular Cell", "d": [], "t": []}, {"i": "NCIT:C36763", "l": "Neoplastic Glandular Cell", "d": [], "t": []}], "preferred_name": "Neoplastic Glandular Cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4240446", "l": "Vascular smooth muscle cell of thoracic aorta", "d": [], "t": []}], "preferred_name": "Vascular smooth muscle cell of thoracic aorta", "taxa": []}
{"type": "biolink:Cell", "ic": 89.40238429118027, "identifiers": [{"i": "CL:4023087", "l": "fan Martinotti neuron", "d": ["A Martinotti neuron that has axons that form a fan-like plexus."], "t": []}], "preferred_name": "fan Martinotti neuron", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5157461", "l": "CD3+CD8+CD28+HLA DR+ cells | Blood | Cell markers", "d": [], "t": []}], "preferred_name": "CD3+CD8+CD28+HLA DR+ cells | Blood | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5854620", "l": "Autologous Anti-MAGE-A1 TCR-engineered T-cells TSC-204-A0201", "d": [], "t": []}, {"i": "NCIT:C201067", "l": "Autologous Anti-MAGE-A1 TCR-engineered T-cells TSC-204-A0201", "d": ["A preparation of autologous T-lymphocytes that are engineered to express a T-cell receptor (TCR) specific for melanoma-associated antigen A1 (MAGE-A1) presented on human leukocyte antigen (HLA)-A*02:01, with potential immunomodulating and antineoplastic activities. Upon administration, the autologous anti-MAGE-A1 TCR-engineered T-cells TSC-204-A0201 specifically recognize and bind to MAGE-A1 expressed on tumor cells. This may lead to cytotoxic T-lymphocyte (CTL)-mediated elimination of tumor cells expressing MAGE-A1. MAGE-A1 is a tumor-associated antigen (TAA) overexpressed by a variety of cancer cell types."], "t": []}], "preferred_name": "Autologous Anti-MAGE-A1 TCR-engineered T-cells TSC-204-A0201", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4033136", "l": "inferior mesenteric ganglion SP neuron", "d": ["A sympathetic neuron that has the soma located in the inferior mesenteric ganglion and expresses the marker substance P (SP)."], "t": []}], "preferred_name": "inferior mesenteric ganglion SP neuron", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C4085965", "l": "Anti-CD3/Anti-EGFR-bispecific Monoclonal Antibody-armed Activated Autologous T-lymphocytes", "d": [], "t": []}, {"i": "NCIT:C125185", "l": "Anti-CD3/Anti-EGFR-bispecific Monoclonal Antibody-armed Activated Autologous T-lymphocytes", "d": ["Autologous activated T-cells that have been coated with bispecific antibodies (BiAb) comprised of an anti-CD3 monoclonal antibody heteroconjugated to an anti-epidermal growth factor receptor (EGFR) monoclonal antibody, with potential antineoplastic and immunomodulating activities. Upon administration, anti-CD3 x anti-EGFR bispecific antibody-armed activated T-cells (AATC) attach to and selectively cross-link CD3-expressing T-cells and EGFR-expressing tumor cells. This results in the activation of cytotoxic T-lymphocytes (CTLs) and selective cytotoxicity towards the EGFR-expressing tumor cells. In addition, cytokine and chemokine secretion by the T-cells further activates the immune system, which leads to the recruitment and activation of CTLs, and additional CTL-mediated tumor-specific cell lysis. CD3 is part of the functional T-cell receptor (TCR) complex, which is necessary for antigen recognition by T-cells, and is required for signal transduction. EGFR, a receptor tyrosine kinase, is overexpressed on the surfaces of various tumor cell types."], "t": []}], "preferred_name": "Anti-CD3/Anti-EGFR-bispecific Monoclonal Antibody-armed Activated Autologous T-lymphocytes", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4068113", "l": "CD3+CD4+CD8+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:1373089001", "l": "", "d": [], "t": []}], "preferred_name": "CD3+CD4+CD8+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5939005", "l": "AGC", "d": [], "t": []}], "preferred_name": "AGC", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5157922", "l": "Cells | Left anterior chamber | NEI eyeGENE slit lamp biomicroscopy", "d": [], "t": []}], "preferred_name": "Cells | Left anterior chamber | NEI eyeGENE slit lamp biomicroscopy", "taxa": []}
{"type": "biolink:Cell", "ic": 71.74874531021723, "identifiers": [{"i": "CL:0000492", "l": "CD4-positive helper T cell", "d": ["A CD4-positive, alpha-beta T cell that cooperates with other lymphocytes via direct contact or cytokine release to initiate a variety of immune functions."], "t": []}], "preferred_name": "CD4-positive helper T cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0024265", "l": "Null cell", "d": [], "t": []}, {"i": "MESH:D008215", "l": "Lymphocytes, Null", "d": [], "t": []}, {"i": "SNOMEDCT:54991005", "l": "", "d": [], "t": []}], "preferred_name": "Null cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1267920", "l": "Lymphocyte positive for CD42 antigen", "d": [], "t": []}, {"i": "SNOMEDCT:117588009", "l": "", "d": [], "t": []}], "preferred_name": "Lymphocyte positive for CD42 antigen", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5977414", "l": "RBC^BldCo", "d": [], "t": []}], "preferred_name": "RBC^BldCo", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5909014", "l": "Tesrivetcel", "d": [], "t": []}, {"i": "NCIT:C203131", "l": "Tesrivetcel", "d": [], "t": []}], "preferred_name": "Tesrivetcel", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0009020", "l": "tuft cell of appendix", "d": ["An intestinal tuft cell that is a part of a vermiform appendix."], "t": []}], "preferred_name": "tuft cell of appendix", "taxa": []}
{"type": "biolink:Cell", "ic": 48.518225630527226, "identifiers": [{"i": "UMLS:C1518293", "l": "Neuron, Neuroepithelial Cell, and Supporting Cell of the Nervous System", "d": [], "t": []}, {"i": "NCIT:C41405", "l": "Neuron, Neuroepithelial Cell, and Supporting Cell of the Nervous System", "d": ["A grouping for all the different types of cells of the nervous system."], "t": []}], "preferred_name": "Neuron, Neuroepithelial Cell, and Supporting Cell of the Nervous System", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1440424", "l": "Cells.XXX", "d": [], "t": []}], "preferred_name": "Cells.XXX", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5925637", "l": "Eque-cel", "d": [], "t": []}], "preferred_name": "Eque-cel", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5174616", "l": "Neutrophils | Control | Blood | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Neutrophils | Control | Blood | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "CL:4033025", "l": "perichondrial fibroblast", "d": ["A fibroblast that is part of the fibrous layer of the perichondrium. This cell is responsible for collagen fiber production."], "t": []}], "preferred_name": "perichondrial fibroblast", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5170955", "l": "Leukocytes other | Pericardial fluid | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Leukocytes other | Pericardial fluid | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4072755", "l": "Cells.TRA+TRD gene rearrangements", "d": [], "t": []}], "preferred_name": "Cells.TRA+TRD gene rearrangements", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0807107", "l": "Vacuolated neutrophil", "d": [], "t": []}, {"i": "SNOMEDCT:726746002", "l": "", "d": [], "t": []}], "preferred_name": "Vacuolated neutrophil", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1440292", "l": "CD3+TCR+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:1376047003", "l": "", "d": [], "t": []}], "preferred_name": "CD3+TCR+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0003027", "l": "retinal ganglion cell D2", "d": ["A bistratified retinal ganglion cell D cell that has medium dendritic arbor and a large dendritic field that terminates in S2 and S4."], "t": []}], "preferred_name": "retinal ganglion cell D2", "taxa": []}
{"type": "biolink:Cell", "ic": 71.39747969210477, "identifiers": [{"i": "CL:0000809", "l": "double-positive, alpha-beta thymocyte", "d": ["A thymocyte expressing the alpha-beta T cell receptor complex as well as both the CD4 and CD8 coreceptors."], "t": []}], "preferred_name": "double-positive, alpha-beta thymocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0009050", "l": "B cell of anorectum", "d": ["A B cell that is located in the anorectum."], "t": []}], "preferred_name": "B cell of anorectum", "taxa": []}
{"type": "biolink:Cell", "ic": 92.76600187037766, "identifiers": [{"i": "UMLS:C1516470", "l": "Chief cell", "d": [], "t": []}, {"i": "NCIT:C12580", "l": "Chief Cell", "d": ["One of three cell types that are found in the gastric or parathyroid glands, or in the carotid body. Gastric chief cells secrete pepsinogen and chymosin. Parathyroid chief cells secrete parathyroid hormone. Type 1 (chief) cells in the carotid body contain neurosecretory vesicles that may play a role in chemoreception."], "t": []}], "preferred_name": "Chief cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C4725099", "l": "Autologous CD38-4SCAR-expressing T-cells 4SCAR38", "d": [], "t": []}, {"i": "NCIT:C148523", "l": "Autologous CD38-4SCAR-expressing T-cells 4SCAR38", "d": ["A preparation of genetically modified autologous T-cells transduced with a replication incompetent, self-inactivating lentiviral vector expressing a fourth generation chimeric antigen receptor (4SCAR) consisting of an anti-CD38 single chain variable fragment (scFv) that is coupled to the costimulatory signaling domains CD28, CD137, CD27 and the zeta chain of the T-cell receptor (TCR), and is fused with the suicide gene inducible caspase 9 (iCasp9), with potential immunostimulating and antineoplastic activities. Upon intravenous administration, autologous CD38-4SCAR-expressing T-cells 4SCAR38 are directed to and induce selective toxicity in CD38-expressing tumor cells. iCasp9 consists of a human FK506 drug-binding domain with an F36V mutation (FKBP12-F36V) linked to human caspase 9. If the administered T-cells lead to unacceptable side effects, the chemical homodimerizer AP1903 can be administered. AP1903 binds to the drug binding FKBP12-F36V domain and induces activation of caspase 9, which results in the apoptosis of the administered T-cells and enhances safety of this agent. CD38, a type II transmembrane glycoprotein, is present on various immune cells and hematologic malignancies, and its expression has been correlated with poor prognosis. CD28, CD137 and CD27, T-cell surface-associated co-stimulatory molecules, are required for full T-cell activation and enhance both proliferation of T-cells and antitumor activity."], "t": []}], "preferred_name": "Autologous CD38-4SCAR-expressing T-cells 4SCAR38", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0000948", "l": "IgE memory B cell", "d": ["A class switched memory B cell that expresses IgE on the cell surface."], "t": []}], "preferred_name": "IgE memory B cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:1000466", "l": "chromaffin cell of right ovary", "d": ["A chromaffin cell that is part of the right ovary."], "t": []}, {"i": "UMLS:C1183981", "l": "Chromaffin cell of right ovary", "d": [], "t": []}], "preferred_name": "chromaffin cell of right ovary", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C2963403", "l": "CD79+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:1372932007", "l": "", "d": [], "t": []}], "preferred_name": "CD79+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4072759", "l": "Cells.MYB gene", "d": [], "t": []}], "preferred_name": "Cells.MYB gene", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C2697996", "l": "Allogeneic LMP1/LMP2-Specific Cytotoxic T-Lymphocytes", "d": [], "t": []}, {"i": "NCIT:C78201", "l": "Allogeneic LMP1/LMP2-Specific Cytotoxic T-Lymphocytes", "d": ["A preparation of cytotoxic T-lymphocytes (CTL), specifically reactive to the Epstein-Barr virus (EBV) latent membrane proteins (LMP) 1 and 2, with potential antineoplastic activity. Peripheral blood mononuclear cells (PBMC) are collected from a donor and are exposed ex vivo to dendritic cells (DCs) transfected with a replication-deficient adenovirus encoding EBV LMP1/2 to generate LMP1/2-specific CTL which are subsequently expanded. Administration of allogeneic LMP1-/LMP2- specific CTL to patients with LMP1/2-positive tumors may result in a specific CTL response against tumor cells expressing LMP1 and LMP2, resulting in cell lysis and inhibition of tumor cell proliferation. As tumor associated antigens (TAAs), LMP1 and LMP2 are expressed in various malignancies including nasopharyngeal cancer and EBV-positive Hodgkin lymphoma."], "t": []}], "preferred_name": "Allogeneic LMP1/LMP2-Specific Cytotoxic T-Lymphocytes", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5556441", "l": "VOR33", "d": [], "t": []}], "preferred_name": "VOR33", "taxa": []}
{"type": "biolink:Cell", "ic": 90.871710685482, "identifiers": [{"i": "CL:1000549", "l": "kidney cortex collecting duct epithelial cell", "d": ["An epithelial cell that is part of a cortical collecting duct."], "t": []}], "preferred_name": "kidney cortex collecting duct epithelial cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1514591", "l": "Pseudoxanthoma Cell", "d": [], "t": []}, {"i": "NCIT:C36740", "l": "Pseudoxanthoma Cell", "d": [], "t": []}], "preferred_name": "Pseudoxanthoma Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 66.49986282425168, "identifiers": [{"i": "CL:4023016", "l": "VIP GABAergic interneuron", "d": ["A transcriptomically distinct GABAergic neuron derived from the CGE and that expresses the vasoactive intestinal polypeptide. Its soma is located in the forebrain.", "A transcriptomically distinct cortical GABAergic neuron that expresses the vasocactive intestinal polypeptide and that has its soma located in the cerebral cortex. The standard transcriptomic reference data for this cell type can be found on the CellxGene census under the collection: 'Transcriptomic cytoarchitecture reveals principles of human neocortex organization', dataset: 'Supercluster: CGE-derived interneurons', Author Categories: 'CrossArea_subclass', cluster Vip."], "t": []}], "preferred_name": "VIP GABAergic interneuron", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C2599785", "l": "Granulocytes.CD59 deficient", "d": [], "t": []}], "preferred_name": "Granulocytes.CD59 deficient", "taxa": []}
{"type": "biolink:Cell", "ic": 92.76600187037766, "identifiers": [{"i": "CL:2000037", "l": "posterior lateral line neuromast hair cell", "d": ["Any neuromast hair cell that is part of a posterior lateral line."], "t": []}], "preferred_name": "posterior lateral line neuromast hair cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0009022", "l": "stromal cell of lamina propria of small intestine", "d": ["A stromal cell found in the lamina propria of the small intestine."], "t": []}], "preferred_name": "stromal cell of lamina propria of small intestine", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C3496269", "l": "B6 cell group", "d": [], "t": []}], "preferred_name": "B6 cell group", "taxa": []}
{"type": "biolink:Cell", "ic": 92.76600187037766, "identifiers": [{"i": "CL:0002482", "l": "dermal melanocyte", "d": ["A melanocyte that produces pigment in the dermis."], "t": []}], "preferred_name": "dermal melanocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 72.0250656653823, "identifiers": [{"i": "CL:1000500", "l": "kidney interstitial cell", "d": ["A cell that is part of kidney interstitium."], "t": []}], "preferred_name": "kidney interstitial cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C6051797", "l": "Allogeneic Anti-EGFR Antibody-conjugated Gamma Delta 2 T-cells ACE2016", "d": [], "t": []}, {"i": "NCIT:C218467", "l": "Allogeneic Anti-EGFR Antibody-conjugated Gamma Delta 2 T-cells ACE2016", "d": ["An off-the-shelf preparation of a subset of allogeneic T-lymphocytes, derived from healthy donors, that express only gamma and delta 2 T-cell receptors (TCRs) conjugated, through antibody cell conjugation (ACC), to an antibody targeting the tumor-associated antigen (TAA) epidermal growth factor receptor (EGFR), with potential immunomodulating and antineoplastic activities. The gamma delta 2 T-cells (gd2 T-cells) and the anti-EGFR antibody were covalently conjugated to selected DNA aptamers that enable DNA hybridization to generate EGFR-targeting gd2 T-cells. Upon administration of the allogeneic anti-EGFR antibody-conjugated gd2 T-cells ACE2016, the anti-EGFR antibody targets and binds to EGFR expressed on tumor cells. The gd2 T-cells secrete interferon-gamma (IFN-g) and exert direct killing of the EGFR-expressing tumor cells. In addition, these cells activate the immune system to exert a cytotoxic T-lymphocyte (CTL) response against EGFR-expressing tumor cells. gd2 T-cells play a key role in the activation of the immune system and do not require major histocompatibility complex (MHC)-mediated antigen presentation to exert their cytotoxic effect. EGFR, a receptor tyrosine kinase overexpressed and/or mutated in many tumor cell types, plays a key role in tumor cell proliferation and tumor vascularization."], "t": []}], "preferred_name": "Allogeneic Anti-EGFR Antibody-conjugated Gamma Delta 2 T-cells ACE2016", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0009098", "l": "fetal and neonatal skeletal muscle fiber", "d": ["A skeletal muscle fiber found at the fetal and neonatal stages. In mammalian fetuses and neonates, skeletal muscle expresses myosin heavy chain-neonatal (MyHC-neo, encoded by the MYH8 gene). This expression disappears shortly after birth and is replaced by expression of adult heavy chain myosins."], "t": []}], "preferred_name": "fetal and neonatal skeletal muscle fiber", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1282866", "l": "Entire blastomere", "d": [], "t": []}, {"i": "SNOMEDCT:343113005", "l": "", "d": [], "t": []}], "preferred_name": "Entire blastomere", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0000950", "l": "IgE plasmablast", "d": ["A plasmablast that secretes IgE."], "t": []}], "preferred_name": "IgE plasmablast", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C3827167", "l": "Autologous ex vivo expanded cd4+-enriched leukocytes treated with the de-methylating agent 5-aza-deoxycytidine", "d": [], "t": []}, {"i": "NCIT:C112495", "l": "Autologous Lymphoid Effector Cells Specific Against Tumor Cells", "d": ["A preparation of cytotoxic, autologous lymphoid effector cells specifically targeted towards tumor cells, with potential immunomodulating and antineoplastic activities. The autologous lymphoid effector cells are prepared by drawing a blood sample containing the required precursors for CD4+ helper T-cells, CD8+ cytotoxic T-cells, and natural killer (NK) cells from a cancer patient. The precursor cells are activated, selected and expanded to generate mature autologous lymphoid effector cells with the potential for enhanced tumor recognition. Upon readministration into the patient, the autologous lymphoid effector cells may induce both humoral and cellular immune responses against tumor cells. This may result in the immune-mediated inhibition of tumor cell proliferation, which leads to tumor cell death."], "t": []}], "preferred_name": "Autologous ex vivo expanded cd4+-enriched leukocytes treated with the de-methylating agent 5-aza-deoxycytidine", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0814995", "l": "Skin cell", "d": [], "t": []}, {"i": "SNOMEDCT:314819008", "l": "", "d": [], "t": []}], "preferred_name": "Skin cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:1000322", "l": "pancreatic goblet cell", "d": ["A goblet cell that is part of the epithelium of pancreatic duct."], "t": []}, {"i": "UMLS:C2326171", "l": "Pancreatic goblet cell", "d": [], "t": []}], "preferred_name": "pancreatic goblet cell", "taxa": []}
{"type": "biolink:Cell", "ic": 90.871710685482, "identifiers": [{"i": "CL:4033081", "l": "cycling myeloid cell", "d": ["A(n) myeloid cell that is cycling."], "t": []}], "preferred_name": "cycling myeloid cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0483189", "l": "CD3+DR+", "d": [], "t": []}], "preferred_name": "CD3+DR+", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "CL:0020045", "l": "Dogiel type II neuron", "d": ["A neuron characterised by Dogiel type II morphology: a large, smooth, oval soma bearing multiple long axon-like processes (multiaxonal) that extend without branching until they reach their targets. The soma lacks the short lamellar or spiny dendrites characteristic of Dogiel type I neurons. Dogiel type II neurons were first described by Alexander Dogiel in 1899 based on methylene blue staining in gastrointestinal ganglia. In the enteric nervous system, Dogiel type II neurons correspond to intrinsic primary afferent neurons (IPANs) and exhibit AH-type electrophysiology (prolonged afterhyperpolarization following an action potential)."], "t": []}], "preferred_name": "Dogiel type II neuron", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1979670", "l": "CD19+IgM+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:1373099006", "l": "", "d": [], "t": []}], "preferred_name": "CD19+IgM+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C2981832", "l": "HER2Bi-Armed Activated T Cells", "d": [], "t": []}, {"i": "NCIT:C88317", "l": "HER2Bi-Armed Activated T Cells", "d": ["Activated T cells (ATC) that have been coated with bispecific antibodies (BiAb), with potential antineoplastic and immunomodulating activities. In vitro, T cells are activated through exposure to the anti-CD3 murine monoclonal antibody OKT3 and interleukin 2 for 14 days and then armed with anti-CD3 x anti-Her2 bispecific antibody (Her2Bi). Upon administration, HER2Bi-armed activated T cells attach to CD3-expressing T cells and HER2/neu-expressing tumor cells, selectively cross-linking T cells and tumor cells; this may result in the recruitment and activation of cytotoxic T lymphocyte (CTLs), CTL perforin-mediated tumor cell cytolysis, and the secretion of antitumor cytokines and chemokines."], "t": []}], "preferred_name": "HER2Bi-Armed Activated T Cells", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C3178867", "l": "Plant Cells", "d": [], "t": []}, {"i": "MESH:D059828", "l": "Plant Cells", "d": [], "t": []}], "preferred_name": "Plant Cells", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:2000091", "l": "endometrial microvascular endothelial cell", "d": ["Any microvascular endothelial cell that is part of a endometrial blood vessel."], "t": []}], "preferred_name": "endometrial microvascular endothelial cell", "taxa": []}
{"type": "biolink:Cell", "ic": 85.53200374075534, "identifiers": [{"i": "CL:0000227", "l": "binucleate cell", "d": ["Any cell that has characteristic some binucleate."], "t": []}, {"i": "UMLS:C0333909", "l": "Binucleate cell", "d": [], "t": []}], "preferred_name": "binucleate cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C0391864", "l": "Cytomegaly", "d": [], "t": []}, {"i": "NCIT:C36735", "l": "Cytomegalic Cell", "d": ["An abnormal cell that contains intranuclear and intracytoplasmic cytomegalovirus inclusion bodies."], "t": []}, {"i": "SNOMEDCT:125392001", "l": "", "d": [], "t": []}], "preferred_name": "Cytomegaly", "taxa": []}
{"type": "biolink:Cell", "ic": 76.40371442623734, "identifiers": [{"i": "CL:0000601", "l": "cochlear outer hair cell", "d": ["A mechanoreceptor in the organ of Corti. In mammals the outer hair cells are arranged in three rows which are further from the modiolus than the single row of inner hair cells. The motile properties of the outer hair cells may contribute actively to tuning the sensitivity and frequency selectivity of the cochlea."], "t": []}], "preferred_name": "cochlear outer hair cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5205502", "l": "Allogeneic CD25/Treg-depleted Donor Lymphocytes", "d": [], "t": []}, {"i": "NCIT:C160729", "l": "Allogeneic CD25/Treg-depleted Donor Lymphocytes", "d": ["A preparation of allogeneic peripheral blood mononuclear cells (PBMCs) derived from an 8/8 HLA-matched donor that have been selectively depleted of CD4+CD25hiFoxp3+ regulatory T-cells (Tregs; CD25hi Tregs) with potential to enhance graft-versus-tumor (GVT) immune responses in patients with myeloid relapse following a hematopoietic stem cell transplant (HSCT) from a matched donor. Following collection and ex-vivo depletion of CD25hi Tregs from PBMCs derived from the original donor, the CD25/Treg-depleted donor lymphocytes are infused into the patient. Upon administration, the CD25/Treg-depleted donor lymphocyte infusion (DLI) may enhance the proliferation of CD4+ and CD8+ effector T-cells (Teffs) and potentially induce curative GVT immune responses in patients with myeloid relapse following HSCT."], "t": []}], "preferred_name": "Allogeneic CD25/Treg-depleted Donor Lymphocytes", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "CL:2000078", "l": "placental pericyte", "d": ["Any pericyte cell that is part of a placenta."], "t": []}], "preferred_name": "placental pericyte", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C2336898", "l": "Hemal stem cell", "d": [], "t": []}], "preferred_name": "Hemal stem cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0004216", "l": "type 5b cone bipolar cell", "d": ["A type 5 cone bipolar cell with diffuse axonal branches."], "t": []}], "preferred_name": "type 5b cone bipolar cell", "taxa": []}
{"type": "biolink:Cell", "ic": 82.62268137420203, "identifiers": [{"i": "CL:0002559", "l": "hair follicle cell", "d": ["An animal cell that is part of a hair follicle."], "t": []}], "preferred_name": "hair follicle cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0002531", "l": "mature CD1a-positive dermal dendritic cell", "d": ["A mature CD1a-positive dermal dendritic cell is CD80-high, CD83-positive, CD86-high, and MHCII-high."], "t": []}], "preferred_name": "mature CD1a-positive dermal dendritic cell", "taxa": []}
{"type": "biolink:Cell", "ic": 72.21593899684457, "identifiers": [{"i": "CL:0002221", "l": "keratinized squamous cell of esophagus", "d": ["A squamous cell that has keratin in the esophagus."], "t": []}, {"i": "UMLS:C1516965", "l": "Keratinized squamous cell of esophagus", "d": [], "t": []}, {"i": "NCIT:C32542", "l": "Esophageal Squamous Cell", "d": ["A flat, scale-like epithelial cell that lines the upper and middle third of the esophageal lumen."], "t": []}], "preferred_name": "keratinized squamous cell of esophagus", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5669732", "l": "Autologous Anti-HER2 CAR-CD28 T Cells", "d": [], "t": []}, {"i": "NCIT:C185166", "l": "Autologous Anti-HER2 CAR-CD28 T Cells", "d": ["A preparation of autologous T-lymphocytes that have been genetically modified to express a chimeric antigen receptor (CAR) targeting the tumor-associated antigen (TAA) human epidermal growth factor receptor 2 (HER2; ErbB2; HER-2) and coupled to the costimulatory domain of CD28, with potential immunostimulating and antineoplastic activities. Upon administration, autologous anti-HER2 CAR-CD28 T cells target and bind to HER2-expressing tumor cells, thereby inducing selective toxicity in HER2-expressing tumor cells. HER2 is overexpressed in a variety of cancer cell types and is associated with increased tumor cell proliferation."], "t": []}], "preferred_name": "Autologous Anti-HER2 CAR-CD28 T Cells", "taxa": []}
{"type": "biolink:Cell", "ic": 87.18682603146104, "identifiers": [{"i": "CL:0009101", "l": "fibroblastic reticular cell", "d": ["A reticular cell involved in directing B cells and T cells to specific regions within a tissue."], "t": []}], "preferred_name": "fibroblastic reticular cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5577049", "l": "Carvykti", "d": [], "t": []}], "preferred_name": "Carvykti", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0002439", "l": "NKGA2-positive natural killer cell, mouse", "d": ["A NK1.1-positive T cell that is NKGA2-positive."], "t": []}], "preferred_name": "NKGA2-positive natural killer cell, mouse", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0229892", "l": "Lymph lymphocyte", "d": [], "t": []}, {"i": "SNOMEDCT:90385004", "l": "", "d": [], "t": []}], "preferred_name": "Lymph lymphocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1518247", "l": "Malignant Tadpole Squamous Cell", "d": [], "t": []}, {"i": "NCIT:C36776", "l": "Malignant Tadpole Squamous Cell", "d": [], "t": []}], "preferred_name": "Malignant Tadpole Squamous Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C4086237", "l": "Dendritic Cell-Precision Multiple Antigen T-Lymphocytes", "d": [], "t": []}, {"i": "NCIT:C125634", "l": "Dendritic Cell-Precision Multiple Antigen T-Lymphocytes", "d": ["A preparation of dendritic cell-precision multiple antigen T-cells (DC-PMAT) that have been induced to specifically target multiple undisclosed tumor-associated antigens (TAAs), with potential antitumor activity. Although the exact mechanism(s) of action through which DC-PMAT cells exert their effects has yet to be elucidated, upon infusion, these cells may stimulate the host immune system to mount a highly-specific cytotoxic T-lymphocyte (CTL) response against tumors expressing common TAAs, which leads to tumor cell lysis."], "t": []}], "preferred_name": "Dendritic Cell-Precision Multiple Antigen T-Lymphocytes", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C0596890", "l": "MCF-7 Cells", "d": [], "t": []}, {"i": "NCIT:C18096", "l": "MCF7", "d": ["An adenocarcinoma cell line established in 1970 from the pleural effusion of a 69 year old Caucasian female patient with breast carcinoma."], "t": []}, {"i": "MESH:D061986", "l": "MCF-7 Cells", "d": [], "t": []}], "preferred_name": "MCF-7 Cells", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5418021", "l": "Anti-GPC3-CAR T-lymphocytes TAK-102", "d": [], "t": []}, {"i": "NCIT:C173713", "l": "Anti-GPC3-CAR T-lymphocytes TAK-102", "d": ["A preparation of T-lymphocytes that have been genetically modified to express a chimeric antigen receptor (CAR) specific for glypican-3 (GPC3), with potential immunostimulating and antineoplastic activities. Upon administration, anti-GPC3-CAR T-lymphocytes TAK-102 specifically targets and binds to GPC3-expressing tumor cells, resulting in tumor cell lysis. GPC3, a heparan sulfate proteoglycan and a member of the glypican family, is overexpressed on certain tumor cell types while minimally expressed on normal, healthy cells; GPC3 plays an important role in cellular proliferation and differentiation."], "t": []}], "preferred_name": "Anti-GPC3-CAR T-lymphocytes TAK-102", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0009037", "l": "lymph node mantle zone B cell", "d": ["A B lymphocyte that resides in the mantle zone of the lymph node germinal center. These are generally IgM and IgD positive activated B cells that form a 'corona' around the germinal center and are part of the establishment of a secondary lymphatic follicule."], "t": []}], "preferred_name": "lymph node mantle zone B cell", "taxa": []}
{"type": "biolink:Cell", "ic": 74.93438803193563, "identifiers": [{"i": "CL:0020035", "l": "intestinal intraepithelial lymphocyte", "d": ["A T cell that is located in the intestinal epithelium and is capable of a mucosal immune response."], "t": []}], "preferred_name": "intestinal intraepithelial lymphocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0009024", "l": "mesothelial cell of small intestine", "d": ["A mesothelial cell that is part of the small intestine."], "t": []}], "preferred_name": "mesothelial cell of small intestine", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1512899", "l": "Interphase Cell", "d": [], "t": []}, {"i": "NCIT:C32869", "l": "Interphase Cell", "d": ["A cell in a resting state. Individual chromosomes are not visible. The cell performs all biochemical and physiologic functions and replication of chromatin occurs."], "t": []}], "preferred_name": "Interphase Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "UMLS:C1883031", "l": "Signet Ring Melanoma Cell", "d": [], "t": []}, {"i": "NCIT:C62402", "l": "Signet Ring Melanoma Cell", "d": [], "t": []}], "preferred_name": "Signet Ring Melanoma Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5418874", "l": "Autologous Anti-CD147 CAR T-cells", "d": [], "t": []}, {"i": "NCIT:C170913", "l": "Autologous Anti-CD147 CAR T-cells", "d": ["A preparation of autologous activated T cells that have been engineered to express chimeric antigen receptors (CARs) specific for the tumor-associated antigen (TAA) CD147 (Basigin; EMMPRIN; extracellular matrix metalloproteinase inducer; OX47; 5A11), with potential antineoplastic activity. Upon administration back into the patient, the anti-CD147 CAR T-cells target and induce selective cytotoxicity in CD147-expressing tumor cells. CD147, a cell-surface glycoprotein of the immunoglobulin G (IgG) superfamily, is overexpressed in certain human tumors and plays an important role in tumor cell proliferation, migration, progression, and metastasis."], "t": []}], "preferred_name": "Autologous Anti-CD147 CAR T-cells", "taxa": []}
{"type": "biolink:Cell", "ic": 89.40238429118027, "identifiers": [{"i": "CL:0009102", "l": "lymph node fibroblastic reticular cell", "d": ["A specialized, fibroblastic reticular cell of mesenchymal origin found in lymph nodes. In human, it expresses several markers common to myofibroblasts (desmin, vimentin, CD73, CD90, α-smooth muscle actin (αSMA)), and can be differentiated from endothelial cells by its lack of CD31 expression. These cells are critical for the overall organization and function of the lymph node. Lymph node fibroblastic reticular cells (FRCs) can be further classified based on their location, function, and unique marker expression."], "t": []}], "preferred_name": "lymph node fibroblastic reticular cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5157337", "l": "CD179a blasts | Bone marrow | Cell markers", "d": [], "t": []}], "preferred_name": "CD179a blasts | Bone marrow | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5427574", "l": "Ganglion cells.left", "d": [], "t": []}], "preferred_name": "Ganglion cells.left", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5172507", "l": "Mesothelial cells | Pleural fluid | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Mesothelial cells | Pleural fluid | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": 86.30756602822301, "identifiers": [{"i": "CL:0000635", "l": "Deiter's cell", "d": ["The outer phalangeal cells of the organ of Corti. This cell holds the base of the hair cell in a cup-shaped depression."], "t": []}], "preferred_name": "Deiter's cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5964750", "l": "Neldaleucel", "d": [], "t": []}], "preferred_name": "Neldaleucel", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1440252", "l": "CD122+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:1372831001", "l": "", "d": [], "t": []}], "preferred_name": "CD122+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4047012", "l": "angiogenic pericyte", "d": ["A specialized pericyte that actively participates in the formation of new blood vessels during angiogenesis by undergoing phenotypic changes, increasing proliferation, and interacting closely with endothelial cells."], "t": []}], "preferred_name": "angiogenic pericyte", "taxa": []}
{"type": "biolink:Cell", "ic": 90.871710685482, "identifiers": [{"i": "UMLS:C1518056", "l": "Lymphoblast-Like Neoplastic B-Lymphocyte", "d": [], "t": []}, {"i": "NCIT:C39748", "l": "Lymphoblast-Like Neoplastic B-Lymphocyte", "d": [], "t": []}], "preferred_name": "Lymphoblast-Like Neoplastic B-Lymphocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0000708", "l": "leptomeningeal cell", "d": ["Stromal cell that forms the internal covering of the vertebrate brain and produces ECM for this and the choroid plexus."], "t": []}], "preferred_name": "leptomeningeal cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5157464", "l": "CD3+DR+ | White blood cells | Cell markers", "d": [], "t": []}], "preferred_name": "CD3+DR+ | White blood cells | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5963646", "l": "SIRPant-M", "d": [], "t": []}], "preferred_name": "SIRPant-M", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5549474", "l": "Spermatozoa | Urine | Fertility testing", "d": [], "t": []}], "preferred_name": "Spermatozoa | Urine | Fertility testing", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0007020", "l": "bottle cell", "d": ["Characteristic early embryonic cell with a bottle or flask shape that is first to migrate inwards at the blastopore during gastrulation in amphibians."], "t": []}], "preferred_name": "bottle cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1977405", "l": "Granulocytes.CD59", "d": [], "t": []}], "preferred_name": "Granulocytes.CD59", "taxa": []}
{"type": "biolink:Cell", "ic": 64.79106753575998, "identifiers": [{"i": "UMLS:C1514034", "l": "Neoplastic Myeloblast", "d": [], "t": []}, {"i": "NCIT:C37065", "l": "Neoplastic Myeloblast", "d": [], "t": []}], "preferred_name": "Neoplastic Myeloblast", "taxa": []}
{"type": "biolink:Cell", "ic": 83.63771255585968, "identifiers": [{"i": "CL:0011108", "l": "colon epithelial cell", "d": ["Epithelial cell that is part of the colon epithelium."], "t": []}], "preferred_name": "colon epithelial cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5235892", "l": "Bone Marrow-Derived Fibroblasts", "d": [], "t": []}, {"i": "NCIT:C164010", "l": "Bone Marrow-Derived Fibroblasts", "d": ["A biological sample containing fibroblasts isolated from the bone marrow of an experimental subject."], "t": []}], "preferred_name": "Bone Marrow-Derived Fibroblasts", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4033024", "l": "airway submucosal gland duct basal cell", "d": ["A basal cell that is part of a duct of an airway submucosal gland."], "t": []}], "preferred_name": "airway submucosal gland duct basal cell", "taxa": []}
{"type": "biolink:Cell", "ic": 37.59556007613422, "identifiers": [{"i": "CL:0011026", "l": "progenitor cell", "d": ["A precursor cell that has a tendency to differentiate into a specific type of cell. They are descendants of stem cells, only they are more constrained in their differentiation potential or capacity for self-renewal, and are often more limited in both senses."], "t": []}], "preferred_name": "progenitor cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:2000033", "l": "limb basal cell of epidermis", "d": ["Any basal cell of epidermis that is part of a limb."], "t": []}], "preferred_name": "limb basal cell of epidermis", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1267813", "l": "Lymphocyte positive for CD2 antigen", "d": [], "t": []}, {"i": "SNOMEDCT:117516003", "l": "", "d": [], "t": []}], "preferred_name": "Lymphocyte positive for CD2 antigen", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C2328888", "l": "Cholinergic amacrine cell of retina", "d": [], "t": []}], "preferred_name": "Cholinergic amacrine cell of retina", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5187201", "l": "RBC^Patient", "d": [], "t": []}], "preferred_name": "RBC^Patient", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4047047", "l": "type I enteric glial cell", "d": ["An enteric glial cell located within the ganglia of the enteric nervous system. This cell is characterized by it’s small somata and short, irregularly branched processes that surround neuronal cell bodies in the myenteric and submucosal ganglia. This cell plays important roles in modulating neuronal activity and neurogenesis in the gastrointestinal tract."], "t": []}], "preferred_name": "type I enteric glial cell", "taxa": []}
{"type": "biolink:Cell", "ic": 89.40238429118027, "identifiers": [{"i": "CL:4030024", "l": "hillock cell", "d": ["An epithelial, transitional cell type between basal and secretory; located in stratified, non-ciliated structures (called hillocks) with high cell turnover in epithelium. In some mammalian species, this cell type has been noted to express KRT13 and is postulated to play a role in squamous barrier function and immunomodulation."], "t": []}], "preferred_name": "hillock cell", "taxa": []}
{"type": "biolink:Cell", "ic": 82.62268137420203, "identifiers": [{"i": "CL:1000320", "l": "large intestine goblet cell", "d": ["A goblet cell that is part of the epithelium of large intestine."], "t": []}, {"i": "UMLS:C2330671", "l": "Goblet cell of epithelium of large intestine", "d": [], "t": []}], "preferred_name": "large intestine goblet cell", "taxa": []}
{"type": "biolink:Cell", "ic": 88.20185721311867, "identifiers": [{"i": "CL:0002047", "l": "fraction B precursor B cell", "d": ["A precursor B cell that is CD45RA-positive, CD43-positive, CD24-positive and BP-1-negative."], "t": []}], "preferred_name": "fraction B precursor B cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C2736931", "l": "CD19+CD56+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:1372984001", "l": "", "d": [], "t": []}], "preferred_name": "CD19+CD56+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": 92.76600187037766, "identifiers": [{"i": "CL:1000343", "l": "paneth cell of epithelium of small intestine", "d": ["A paneth cell that is part of the epithelium of small intestine."], "t": []}], "preferred_name": "paneth cell of epithelium of small intestine", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0815002", "l": "GABAergic Neurons", "d": [], "t": []}, {"i": "MESH:D059330", "l": "GABAergic Neurons", "d": [], "t": []}], "preferred_name": "GABAergic Neurons", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1640380", "l": "Bone Marrow Stromal Cells", "d": [], "t": []}], "preferred_name": "Bone Marrow Stromal Cells", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1440356", "l": "CD79b+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:1372933002", "l": "", "d": [], "t": []}], "preferred_name": "CD79b+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1517638", "l": "KA08", "d": [], "t": []}, {"i": "NCIT:C20268", "l": "KA08", "d": ["Provider: Karolinska Institute, Stockholm, Sweden. No information from provider. This cell line meets the criteria for the use of human embryonic stem cells by federally funded researchers."], "t": []}], "preferred_name": "KA08", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5216239", "l": "Leukocytes|NCnc|Pt|Plr fld", "d": [], "t": []}], "preferred_name": "Leukocytes|NCnc|Pt|Plr fld", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5706469", "l": "Autologous Anti-CD19 CAR-expressing T-lymphocytes UF-KURE19", "d": [], "t": []}, {"i": "NCIT:C188238", "l": "Autologous Anti-CD19 CAR-expressing T-lymphocytes UF-KURE19", "d": ["A preparation of autologous T-lymphocytes that have been genetically modified and transduced with a lentiviral vector to express a chimeric antigen receptor (CAR) that targets the human tumor-associated antigen (TAA) CD19, with potential immunostimulating and antineoplastic activities. Upon administration, autologous anti-CD19 CAR-expressing T-lymphocytes UF-KURE19 bind to and induce selective toxicity against CD19-expressing tumor cells. The CD19 antigen is a B-cell-specific cell surface antigen expressed in all B-cell lineage malignancies."], "t": []}], "preferred_name": "Autologous Anti-CD19 CAR-expressing T-lymphocytes UF-KURE19", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1440288", "l": "CD3+CD8+CD45RA+CD45RO+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:1373274002", "l": "", "d": [], "t": []}], "preferred_name": "CD3+CD8+CD45RA+CD45RO+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0000849", "l": "crypt olfactory receptor neuron", "d": ["An olfactory receptor cell with short cilia growing in an invagination bordered by microvilli."], "t": []}], "preferred_name": "crypt olfactory receptor neuron", "taxa": []}
{"type": "biolink:Cell", "ic": 92.76600187037766, "identifiers": [{"i": "CL:0000779", "l": "multinuclear osteoclast", "d": ["A specialized multinuclear osteoclast, forming a syncytium through the fusion of mononuclear precursor cells, associated with the absorption and removal of bone."], "t": []}], "preferred_name": "multinuclear osteoclast", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5555574", "l": "Autologous Anti-CD30 CAR T Cells HSP-CAR30", "d": [], "t": []}, {"i": "NCIT:C179274", "l": "Autologous Anti-CD30 CAR T Cells HSP-CAR30", "d": ["A preparation of autologous T-lymphocytes that have been genetically modified to express a chimeric antigen receptor (CAR) specific for the CD30 antigen, with potential immunostimulating and antineoplastic activities. Upon administration, autologous anti-CD30 CAR T cells HSP-CAR30 specifically recognize and bind to CD30-expressing tumor cells, resulting in tumor cell lysis. CD30, a cell surface receptor and a member of the tumor necrosis factor (TNF) receptor superfamily, is transiently expressed on activated lymphocytes and is constitutively expressed in hematologic malignancies."], "t": []}], "preferred_name": "Autologous Anti-CD30 CAR T Cells HSP-CAR30", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C6049814", "l": "Anzutresgene Autoleucel", "d": [], "t": []}, {"i": "NCIT:C215289", "l": "Anzutresgene Autoleucel", "d": ["A preparation of autologous T-lymphocytes that are genetically modified with a lentiviral vector encoding a T-cell receptor (TCR) specific for the tumor-associated antigen (TAA) preferentially expressed antigen in melanoma (PRAME), with potential antineoplastic activity. Upon intravenous administration back into the patient, anzutresgene autoleucel specifically recognize and bind to PRAME expressed on cancer cells, which induces a cytotoxic T-lymphocyte (CTL)-mediated immune response against the PRAME-expressing cancer cells. PRAME is overexpressed by a variety of cancer cell types."], "t": []}], "preferred_name": "Anzutresgene Autoleucel", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0314586", "l": "Colony-forming unit of eosinophilic lineage", "d": [], "t": []}, {"i": "SNOMEDCT:445115004", "l": "", "d": [], "t": []}], "preferred_name": "Colony-forming unit of eosinophilic lineage", "taxa": []}
{"type": "biolink:Cell", "ic": 61.83487900080614, "identifiers": [{"i": "UMLS:C1518177", "l": "Malignant Epithelial Large Cell", "d": [], "t": []}, {"i": "NCIT:C36822", "l": "Malignant Epithelial Large Cell", "d": [], "t": []}], "preferred_name": "Malignant Epithelial Large Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 89.40238429118027, "identifiers": [{"i": "CL:1000324", "l": "duodenal goblet cell", "d": ["A goblet cell that is part of the epithelium proper of duodenum."], "t": []}, {"i": "UMLS:C2330431", "l": "Goblet cell of epithelium proper of duodenum", "d": [], "t": []}], "preferred_name": "duodenal goblet cell", "taxa": []}
{"type": "biolink:Cell", "ic": 71.48355502057495, "identifiers": [{"i": "UMLS:C1513939", "l": "Neoplastic Chondrocyte", "d": [], "t": []}, {"i": "NCIT:C36983", "l": "Neoplastic Chondrocyte", "d": [], "t": []}], "preferred_name": "Neoplastic Chondrocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 90.871710685482, "identifiers": [{"i": "UMLS:C1512246", "l": "Goteborg ES Cell Line", "d": [], "t": []}, {"i": "NCIT:C20263", "l": "Goteborg ES Cell Line", "d": [], "t": []}], "preferred_name": "Goteborg ES Cell Line", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1565000", "l": "Retinal Horizontal Cells", "d": [], "t": []}, {"i": "MESH:D051248", "l": "Retinal Horizontal Cells", "d": [], "t": []}], "preferred_name": "Retinal Horizontal Cells", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5157348", "l": "CD19 cells | XXX | Cell markers", "d": [], "t": []}], "preferred_name": "CD19 cells | XXX | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0004226", "l": "monostratified amacrine cell", "d": ["An amacrine cell with a small dendritic field with post-synaptic terminals in S3 and S4."], "t": []}], "preferred_name": "monostratified amacrine cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4517379", "l": "Population of all large unstained cells in portion of fluid", "d": [], "t": []}, {"i": "SNOMEDCT:732290004", "l": "", "d": [], "t": []}], "preferred_name": "Population of all large unstained cells in portion of fluid", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5163547", "l": "Epithelial cells.ciliated | Bronchoalveolar lavage | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Epithelial cells.ciliated | Bronchoalveolar lavage | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": 87.18682603146104, "identifiers": [{"i": "CL:1000405", "l": "epithelial cell of appendix", "d": ["An epithelial cell that is part of the appendix."], "t": []}, {"i": "UMLS:C1179760", "l": "Epithelial cell of appendix", "d": [], "t": []}], "preferred_name": "epithelial cell of appendix", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0002565", "l": "iris pigment epithelial cell", "d": ["A pigment cell located in the epithelium of the iris."], "t": []}], "preferred_name": "iris pigment epithelial cell", "taxa": []}
{"type": "biolink:Cell", "ic": 75.876659701315, "identifiers": [{"i": "CL:0000677", "l": "gut absorptive cell", "d": ["Cell of the intestinal epithelium with a brush border made up of many parallel packed microvilli; associated with absorption, particularly of macromolecules."], "t": []}], "preferred_name": "gut absorptive cell", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "UMLS:C1711280", "l": "Neoplastic Somatotroph Cell with Scarce Secretory Granules", "d": [], "t": []}, {"i": "NCIT:C45940", "l": "Neoplastic Somatotroph Cell with Scarce Secretory Granules", "d": [], "t": []}], "preferred_name": "Neoplastic Somatotroph Cell with Scarce Secretory Granules", "taxa": []}
{"type": "biolink:Cell", "ic": 70.82453858732072, "identifiers": [{"i": "UMLS:C1514095", "l": "Neoplastic Small to Medium-Sized Lymphocyte", "d": [], "t": []}, {"i": "NCIT:C36990", "l": "Neoplastic Small to Medium-Sized Lymphocyte", "d": [], "t": []}], "preferred_name": "Neoplastic Small to Medium-Sized Lymphocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 92.76600187037766, "identifiers": [{"i": "CL:4042009", "l": "interlaminar astrocyte", "d": ["An astrocyte type that presents radial protrusions across the layers of a cortex. The soma of this astrocyte is part of the first layer of a neocortex. This astrocyte extents its protrusions transversally to the deeper layers of a cortex and it creates contact with neurons, the pia matter and capillaries. This astrocyte is involved in facilitating the communication across neurons, astrocytes, capillaries, meninges and the cerebrospinal fluid."], "t": []}], "preferred_name": "interlaminar astrocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4307112", "l": "OEC NN_1 Rasgef1c olfactory ensheathing cell (Mmus)", "d": ["A olfactory ensheathing cell of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Apod (Mmus), Mybpc1 (Mmus), Rasgef1c (Mmus). It is distinguished from other OEC cells by expression of Rasgef1c. It is glutamatergic. These cells are located in the brain . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5292 OEC NN_1.", "A olfactory ensheathing cell of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Apod (Mmus), Mybpc1 (Mmus), Rasgef1c (Mmus). It is distinguished from other OEC cells by expression of Rasgef1c. It is glutamatergic (inferred from expression of Slc17a7). These cells are located in the brain . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5292 OEC NN_1."], "t": []}], "preferred_name": "OEC NN_1 Rasgef1c olfactory ensheathing cell (Mmus)", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0002455", "l": "CD8-alpha-negative plasmacytoid dendritic cell", "d": ["A CD11c-low plasmacytoid dendritic cell that is CD8-alpha-negative and CD4-positive."], "t": []}], "preferred_name": "CD8-alpha-negative plasmacytoid dendritic cell", "taxa": []}
{"type": "biolink:Cell", "ic": 42.72206562654929, "identifiers": [{"i": "CL:0000108", "l": "cholinergic neuron", "d": ["A neuron that uses acetylcholine as a vesicular neurotransmitter."], "t": []}, {"i": "UMLS:C2333949", "l": "Cholinergic Neurons", "d": [], "t": []}, {"i": "MESH:D059329", "l": "Cholinergic Neurons", "d": [], "t": []}], "preferred_name": "cholinergic neuron", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C4289951", "l": "Autologous HBV-specific TCR-redirected T-Lymphocytes", "d": [], "t": []}, {"i": "NCIT:C126270", "l": "Autologous HBV-specific TCR-redirected T-Lymphocytes", "d": ["A preparation of human autologous T-lymphocytes transduced with a viral vector encoding for a T-cell receptor (TCR) specific for a human hepatitis B virus (HBV) surface antigen (HBsAg), with potential antineoplastic activity. Following administration, the autologous HBV antigen specific TCR-redirected autologous T-lymphocytes recognize and bind to the HBV antigen-positive cells, which induces cytotoxic T-lymphocyte (CTL)-mediated elimination of HBV antigen-positive cancer cells. HBV antigens are found on HBV-positive cells and HPV-induced hepatocellular carcinoma (HCC)."], "t": []}], "preferred_name": "Autologous HBV-specific TCR-redirected T-Lymphocytes", "taxa": []}
{"type": "biolink:Cell", "ic": 73.15076615569336, "identifiers": [{"i": "UMLS:C1709183", "l": "Neoplastic Lipoblast", "d": [], "t": []}, {"i": "NCIT:C48878", "l": "Neoplastic Lipoblast", "d": [], "t": []}], "preferred_name": "Neoplastic Lipoblast", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5983491", "l": "Resecabtagene Autoleucel", "d": [], "t": []}, {"i": "NCIT:C211706", "l": "Resecabtagene Autoleucel", "d": [], "t": []}], "preferred_name": "Resecabtagene Autoleucel", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1441345", "l": "100 spermatozoa", "d": [], "t": []}], "preferred_name": "100 spermatozoa", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0001013", "l": "mature interstitial dendritic cell", "d": ["Mature interstitial dendritic cell is a interstitial dendritic cell that is CD80-high, CD86-high, MHCII-high and is CD83-positive."], "t": []}], "preferred_name": "mature interstitial dendritic cell", "taxa": []}
{"type": "biolink:Cell", "ic": 90.871710685482, "identifiers": [{"i": "UMLS:C1514114", "l": "Neoplastic Thyrotroph Cell", "d": [], "t": []}, {"i": "NCIT:C36922", "l": "Neoplastic Thyrotroph Cell", "d": [], "t": []}], "preferred_name": "Neoplastic Thyrotroph Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5706516", "l": "Engineered Red Blood Cells Expressing 4-1BBL/IL-12 RTX-224", "d": [], "t": []}, {"i": "NCIT:C188894", "l": "Engineered Red Blood Cells Expressing 4-1BBL/IL-12 RTX-224", "d": ["An off-the-shelf (OTS) preparation of allogeneic red blood cells (RBCs) genetically engineered with a lentiviral vector to express on the cell surface the co-stimulatory molecule tumor necrosis factor ligand superfamily (TNFSF) member 9 (TNFSF9; 4-1BBL) and the immunostimulatory cytokine interleukin-12 (IL-12), with potential immunomodulating and antineoplastic activities. Upon administration of the engineered RBCs expressing 4-1BBL/IL-12 RTX-224, 4-1BBL and IL-12 expressed on these cells bind to 4-1BB and IL-12 receptors. This induces the proliferation and activation of CD4- and CD8-positive T-cells and natural killer (NK) cells, which induces the production of inflammatory cytokines and chemokines, and leads to the activation of antigen-presenting cells (APCs) and enhanced antigen presentation. Altogether, this activates both the adaptive and innate immune system and leads to the induction of anti-tumor immune responses, thereby killing the tumor cells. 4-1BB, a surface glycoprotein of the tumor necrosis factor receptor superfamily (TNFRSF), is an inducible costimulatory receptor that plays a key role in T-cell proliferation, survival and cytolytic activity. IL-12 promotes the activation of NK cells."], "t": []}], "preferred_name": "Engineered Red Blood Cells Expressing 4-1BBL/IL-12 RTX-224", "taxa": []}
{"type": "biolink:Cell", "ic": 80.96785908349635, "identifiers": [{"i": "CL:0000900", "l": "naive thymus-derived CD8-positive, alpha-beta T cell", "d": ["A CD8-positive, alpha-beta T cell that has not experienced activation via antigen contact and has the phenotype CD45RA-positive, CCR7-positive and CD127-positive. This cell type is also described as being CD25-negative, CD62L-high and CD44-low."], "t": []}], "preferred_name": "naive thymus-derived CD8-positive, alpha-beta T cell", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "CL:0002109", "l": "B220-positive CD38-positive naive B cell", "d": ["A B220-positive CD38-positive naive B cell is a CD38-positive naive B cell that has the phenotype B220-positive, CD38-positive, surface IgD-positive, surface IgM-positive, and CD27-negative, and that has not yet been activated by antigen in the periphery."], "t": []}], "preferred_name": "B220-positive CD38-positive naive B cell", "taxa": []}
{"type": "biolink:Cell", "ic": 58.82060815034062, "identifiers": [{"i": "CL:0000153", "l": "glycosaminoglycan secreting cell", "d": ["A cell that secretes glycosaminoglycans."], "t": []}], "preferred_name": "glycosaminoglycan secreting cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5420525", "l": "Allogeneic PD-L1 Tumor-targeted High-affinity Natural Killer Cells", "d": [], "t": []}, {"i": "NCIT:C174011", "l": "Allogeneic PD-L1 Tumor-targeted High-affinity Natural Killer Cells", "d": ["A preparation of natural killer (NK) cells that are derived from NK-92 cells, a human cytotoxic cell line composed of allogeneic NK cells derived from a 50-year old male patient with rapidly progressive non-Hodgkin's lymphoma (NHL), that are genetically engineered to express the high-affinity CD16/FcgammaRIIIa (158V) allele, endoplasmic reticulum (ER)-retained interleukin (IL)-2 and a chimeric antigen receptor (CAR) specific for programmed death-ligand 1 (PD-L1), with potential immunomodulating, cytolytic and antineoplastic activities. Upon infusion of the PD-L1 tumor-targeted high-affinity (ha) NK cells, the NK cells recognize and bind to tumor cells, preferentially to PD-L1-expressing tumor cells and human peripheral myeloid-derived suppressor cells (MDSCs). This leads to the secretion and release of perforins, granzymes, cytokines and chemokines, and results in cancer cell lysis and apoptosis. In addition, the incorporation of the high-affinity CD16 allele allows the NK cells to lyse tumor cells via antibody-dependent cell-mediated cytotoxicity (ADCC) mediated by tumor-antigen-specific immunoglobulin G1 (IgG1) antibodies through binding of CD16 with the Fc region of human IgG1 antibodies. IL-2 replenishes the granular stock of NK cells, leading to enhanced perforin- and granzyme-mediated lysis of tumor cells."], "t": []}], "preferred_name": "Allogeneic PD-L1 Tumor-targeted High-affinity Natural Killer Cells", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5421200", "l": "prademagene zamikeracel", "d": [], "t": []}, {"i": "NCIT:C175196", "l": "Prademagene Zamikeracel", "d": [], "t": []}], "preferred_name": "prademagene zamikeracel", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4310126", "l": "STR-BF TAC3-PLPP4-LHX8 GABA TAC3-positive striatal interneuron (Primate)", "d": ["A TAC3-positive striatal interneuron of the Primates brain. These cells are located in the striatum . Reference transcriptomic data for this type can be found in the dataset/taxonomy - HMBA Basal Ganglia Consensus Taxonomy in cell set Group:STR-BF TAC3-PLPP4-LHX8 GABA."], "t": []}], "preferred_name": "STR-BF TAC3-PLPP4-LHX8 GABA TAC3-positive striatal interneuron (Primate)", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0333858", "l": "Small non-cleaved cell", "d": [], "t": []}, {"i": "SNOMEDCT:33872006", "l": "", "d": [], "t": []}], "preferred_name": "Small non-cleaved cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C4086897", "l": "Tergenpumatucel-L", "d": [], "t": []}, {"i": "NCIT:C66985", "l": "Tergenpumatucel-L", "d": ["An allogeneic lung cancer vaccine with potential immunostimulating and antineoplastic activities. Derived from allogeneic lung tumor cells, tergenpumatucel-L is engineered to express the murine alpha-1,3-galactosyltransferase (GalT), an enzyme humans lack. GalT catalyzes the expression of foreign alpha-1,3-galactosyl (alpha-gal) carbohydrate epitopes in glycoproteins and in glycolipids on the cell membranes of the allogeneic lung tumor cells present in the vaccine, essentially producing a 'xenograft'. The hyperacute rejection involves pre-existing human anti-alpha-gal antibodies that bind the foreign alpha-gal epitopes expressed by the vaccine tumor cell xenograft, resulting in complement-mediated cytotoxicity (CMC) and antibody-dependent cell-mediated cytotoxicity (ADCC) towards endogenous lung tumor cells with unmodified carbohydrate epitopes."], "t": []}], "preferred_name": "Tergenpumatucel-L", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5854469", "l": "Allogeneic Hypoimmune Anti-CD19 CAR T-cells SC291", "d": [], "t": []}, {"i": "NCIT:C200072", "l": "Allogeneic Hypoimmune Anti-CD19 CAR T-cells SC291", "d": ["A preparation of human allogeneic T-lymphocytes transduced with a chimeric antigen receptor (CAR) specific for the tumor-associated antigen (TAA) CD19, and modified ex vivo to disrupt the expression of major histocompatibility (MHC) class I and MHC class II molecules and to express CD47, with potential immunomodulating and antineoplastic activities. Upon introduction into the patient, the allogeneic hypoimmune anti-CD19 CAR T-cells SC291 recognize and bind to CD19-expressing tumor cells. This may result in a specific cytotoxic T-lymphocyte (CTL)-mediated killing of CD19-positive tumor cells. CD19 antigen is a B-cell specific cell surface antigen expressed in all B-cell lineage malignancies. The disruption of MHC class I and MHC class II molecules and the expression of CD47 prevent immune response against the allogeneic CAR T-cells, thereby increasing the persistence of the CAR T-cells."], "t": []}], "preferred_name": "Allogeneic Hypoimmune Anti-CD19 CAR T-cells SC291", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1511439", "l": "CH01", "d": [], "t": []}, {"i": "NCIT:C20285", "l": "CH01", "d": ["Provider: Pochon CHA University, Seoul, Korea. No information from provider. This cell line meets the criteria for the use of human embryonic stem cells by federally funded researchers."], "t": []}], "preferred_name": "CH01", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1520164", "l": "Xanthoma Cell", "d": [], "t": []}, {"i": "NCIT:C36845", "l": "Xanthoma Cell", "d": [], "t": []}], "preferred_name": "Xanthoma Cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4304492", "l": "Population of all granulocytes in portion of fluid", "d": [], "t": []}, {"i": "SNOMEDCT:719696007", "l": "", "d": [], "t": []}], "preferred_name": "Population of all granulocytes in portion of fluid", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5157920", "l": "Cells | Body fluid | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Cells | Body fluid | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4037921", "l": "Cell negative for CD3 antigen and positive for CD8 antigen", "d": [], "t": []}, {"i": "SNOMEDCT:1373190008", "l": "", "d": [], "t": []}], "preferred_name": "Cell negative for CD3 antigen and positive for CD8 antigen", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1440264", "l": "CD18+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:1372858008", "l": "", "d": [], "t": []}], "preferred_name": "CD18+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5939433", "l": "Lymphocytes|NCnc|Pt|XXX", "d": [], "t": []}], "preferred_name": "Lymphocytes|NCnc|Pt|XXX", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:1000371", "l": "transitional myocyte of right branch of atrioventricular bundle", "d": ["A transitional myocyte that is part of the right branch of atrioventricular bundle."], "t": []}, {"i": "UMLS:C2330686", "l": "Transitional myocyte of right branch of atrioventricular bundle", "d": [], "t": []}], "preferred_name": "transitional myocyte of right branch of atrioventricular bundle", "taxa": []}
{"type": "biolink:Cell", "ic": 87.18682603146104, "identifiers": [{"i": "CL:4023027", "l": "L5 sst T-Martinotti interneuron (Mmus)", "d": ["A sst GABAergic cortical interneuron with a soma found in L5 and possesses 'T-shaped' Martinotti morphologies with local axonal plexus in L5a and translaminar axons restricted to the uppermost part of L1. They show low-threshold spiking patterns with strong rebound firing, and inhibit the L1 apical tuft of nearby pyramidal cells."], "t": []}], "preferred_name": "L5 sst T-Martinotti interneuron (Mmus)", "taxa": []}
{"type": "biolink:Cell", "ic": 83.63771255585968, "identifiers": [{"i": "UMLS:C1513982", "l": "Neoplastic Somatotroph Cell", "d": [], "t": []}, {"i": "NCIT:C36919", "l": "Neoplastic Somatotroph Cell", "d": [], "t": []}], "preferred_name": "Neoplastic Somatotroph Cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5426635", "l": "CD3-CD14-CD45+CD56+DOCK8+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:1373225003", "l": "", "d": [], "t": []}], "preferred_name": "CD3-CD14-CD45+CD56+DOCK8+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0333765", "l": "Target fibers", "d": [], "t": []}, {"i": "SNOMEDCT:39037003", "l": "", "d": [], "t": []}], "preferred_name": "Target fibers", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5961162", "l": "Autologous CAR-engineered Regulatory T-cells SBT777101", "d": [], "t": []}, {"i": "NCIT:C208345", "l": "Autologous CAR-engineered Regulatory T-cells SBT777101", "d": ["A preparation of autologous T-regulatory cells (Tregs) that have been genetically modified to express a chimeric antigen receptor (CAR) targeting citrullinated proteins, with potential immunmodulating activity. Upon administration, the autologous CAR-engineered regulatory T-cells SBT777101 target and bind to citrullinated proteins and may decrease inflammation and promote immunologic homeostasis. Citrullinated proteins are found in inflamed disease-associated tissues in many autoimmune and inflammatory diseases."], "t": []}], "preferred_name": "Autologous CAR-engineered Regulatory T-cells SBT777101", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1513469", "l": "Monocytoid B-Lymphocyte", "d": [], "t": []}, {"i": "NCIT:C33138", "l": "Monocytoid B-Lymphocyte", "d": ["A lymphocyte derived most often from a pre-germinal center B cell, less often from a post-germinal center B cell. It is characterized by an abundant pale cytoplasm, indented nuclei with inconspicuous nucleoli, and open chromatin. It is found in the marginal zones of lymph nodes adjacent to the subcapsular and intermediary sinuses."], "t": []}], "preferred_name": "Monocytoid B-Lymphocyte", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5181334", "l": "Spermatozoa | Semen | Fertility testing", "d": [], "t": []}], "preferred_name": "Spermatozoa | Semen | Fertility testing", "taxa": []}
{"type": "biolink:Cell", "ic": 89.40238429118027, "identifiers": [{"i": "UMLS:C1514017", "l": "CD4+/CD56+ Neoplastic Medium-Sized Cell", "d": [], "t": []}, {"i": "NCIT:C39301", "l": "CD4+/CD56+ Neoplastic Medium-Sized Cell", "d": [], "t": []}], "preferred_name": "CD4+/CD56+ Neoplastic Medium-Sized Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 78.29800561113302, "identifiers": [{"i": "UMLS:C1708908", "l": "Malignant Small Squamous Cell", "d": [], "t": []}, {"i": "NCIT:C54207", "l": "Malignant Small Squamous Cell", "d": [], "t": []}], "preferred_name": "Malignant Small Squamous Cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5853784", "l": "CLZ-2002", "d": [], "t": []}], "preferred_name": "CLZ-2002", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C2328553", "l": "Transitional myocyte of sinuatrial node", "d": [], "t": []}], "preferred_name": "Transitional myocyte of sinuatrial node", "taxa": []}
{"type": "biolink:Cell", "ic": 89.40238429118027, "identifiers": [{"i": "UMLS:C1511324", "l": "BresaGen ES Cell Line", "d": [], "t": []}, {"i": "NCIT:C20247", "l": "BresaGen ES Cell Line", "d": [], "t": []}], "preferred_name": "BresaGen ES Cell Line", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0085820", "l": "Antibody-Secreting Cells", "d": [], "t": []}], "preferred_name": "Antibody-Secreting Cells", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0002295", "l": "type-6 epithelial cell of thymus", "d": ["A thymic epithelial cell that has an eccentric, round, or irregularly shaped hetero or euchromatic nucleus. The hallmark of this cell type is the presence of vacuoles, which are clustered in one area of the cytoplasm in the vicinity of the nucleus. The vacuoles are small and acquire a grape-like form, occasionally showing delicate internal microvillous projections."], "t": []}, {"i": "UMLS:C1183362", "l": "Type-6 epithelial cell of thymus", "d": [], "t": []}], "preferred_name": "type-6 epithelial cell of thymus", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5418087", "l": "RAPA-201", "d": [], "t": []}, {"i": "NCIT:C174405", "l": "Autologous Rapamycin-resistant Th1/Tc1 Cells RAPA-201", "d": ["A preparation of autologous rapamycin-resistant Th1/Tc1 cells, with potential immunomodulating activity. Upon administration, autologous rapamycin-resistant Th1/Tc1 cells RAPA-201 may recognize and kill tumor cells. Ex-vivo induction of rapamycin-resistance may increase the persistence of T-cells after adoptive transfer."], "t": []}], "preferred_name": "RAPA-201", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5163729", "l": "Erythrocytes | Urine sediment | Urinalysis", "d": [], "t": []}], "preferred_name": "Erythrocytes | Urine sediment | Urinalysis", "taxa": []}
{"type": "biolink:Cell", "ic": 82.16838616155795, "identifiers": [{"i": "CL:0000158", "l": "club cell", "d": ["A non-mucous, epithelial secretory cell that is part of the tracheobronchial tree. A club cell has short microvilli but no cilia. A club cell is able to multiply and differentiate into ciliated cells to regenerate the bronchiolar epithelium and it also protects the tracheobronchial epithelium."], "t": []}], "preferred_name": "club cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1511469", "l": "CY91", "d": [], "t": []}, {"i": "NCIT:C20243", "l": "CY91", "d": ["Provider: CyThera, Inc., San Diego, CA. No information from provider. This cell line meets the criteria for the use of human embryonic stem cells by federally funded researchers."], "t": []}], "preferred_name": "CY91", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5182725", "l": "Target cells | Blood | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Target cells | Blood | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5174098", "l": "Myelocytes | Cerebral spinal fluid | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Myelocytes | Cerebral spinal fluid | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5171962", "l": "Malignant cells | Pericardial fluid | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Malignant cells | Pericardial fluid | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": 76.9766555310214, "identifiers": [{"i": "UMLS:C1879883", "l": "Blastemal Cell", "d": [], "t": []}, {"i": "NCIT:C61288", "l": "Blastemal Cell", "d": ["An embryonic undifferentiated cell that can grow and differentiate into organs or body parts."], "t": []}], "preferred_name": "Blastemal Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0000427", "l": "GLR cell", "d": ["A scaffolding cell type found in C. elegans, this cell plays a supportive role to the muscle arms. May also have an endocrine role."], "t": []}], "preferred_name": "GLR cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5157544", "l": "CD4+CD45RA+ cells | Blood | Cell markers", "d": [], "t": []}], "preferred_name": "CD4+CD45RA+ cells | Blood | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5174622", "l": "Neutrophils | Pleural fluid | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Neutrophils | Pleural fluid | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4697018", "l": "CD21+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:1372863007", "l": "", "d": [], "t": []}], "preferred_name": "CD21+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5983481", "l": "NK Cell-priming Inert Tumor Cells", "d": [], "t": []}], "preferred_name": "NK Cell-priming Inert Tumor Cells", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5157477", "l": "CD30 cells | XXX | Cell markers", "d": [], "t": []}], "preferred_name": "CD30 cells | XXX | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": 81.34422831136257, "identifiers": [{"i": "CL:0000218", "l": "myelinating Schwann cell", "d": ["A neuroglial cell of the peripheral nervous system which forms the insulating myelin sheaths of peripheral axons."], "t": []}], "preferred_name": "myelinating Schwann cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C6056193", "l": "NGN-101", "d": [], "t": []}], "preferred_name": "NGN-101", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5163445", "l": "Eosinophils | Sputum | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Eosinophils | Sputum | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5163444", "l": "Eosinophils | Pleural fluid | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Eosinophils | Pleural fluid | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1524103", "l": "Mouse Glial Cell", "d": [], "t": []}, {"i": "NCIT:C22613", "l": "Mouse Glial Cell", "d": [], "t": []}], "preferred_name": "Mouse Glial Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 88.20185721311867, "identifiers": [{"i": "UMLS:C1709173", "l": "Neoplastic Epithelioid Neuroendocrine Cell", "d": [], "t": []}, {"i": "NCIT:C48593", "l": "Neoplastic Epithelioid Neuroendocrine Cell", "d": [], "t": []}], "preferred_name": "Neoplastic Epithelioid Neuroendocrine Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C4055460", "l": "Anti-CEA-CAR Autologous T Lymphocytes", "d": [], "t": []}, {"i": "NCIT:C121784", "l": "Anti-CEA-CAR Autologous T Lymphocytes", "d": ["Autologous lymphocytes transduced with a retroviral vector encoding a chimeric antigen receptor (CAR) specific for the tumor-associated antigen human carcinoembryonic antigen (CEA), with potential immunostimulating and antineoplastic activities. Upon administration, the anti-CEA-CAR autologous T-lymphocytes target and bind to tumor cells expressing CEA, which results in the cytotoxic T-lymphocyte (CTL)-mediated cell killing of CEA-expressing tumor cells. CEA is overexpressed in various tumor cell types."], "t": []}], "preferred_name": "Anti-CEA-CAR Autologous T Lymphocytes", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0005023", "l": "branchiomotor neuron", "d": ["Cranial motor neuron which innervates muscles derived from the branchial (pharyngeal) arches."], "t": []}], "preferred_name": "branchiomotor neuron", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4042030", "l": "candelabrum cell", "d": ["A GABAergic interneuron located in the Purkinje layer of the cerebellar cortex. This GABAergic interneuron type has a distinct morphology, it presents a small cell soma near the Purkinje cell layer (PCL), dendrites that extend to the surface of the molecular layer, and beaded axons that make local synapses contacts within the molecular layer. A candelabrum cell is excited by mossy fibers and granule cells but inhibited by Purkinje cells, and it inhibits molecular layer interneurons, which leads to the disinhibition of Purkinje cells."], "t": []}], "preferred_name": "candelabrum cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5206851", "l": "Autologous Active IL-7 Receptor Co-expressing GD2-specific CAR T-cells", "d": [], "t": []}, {"i": "NCIT:C162873", "l": "Autologous Active IL-7 Receptor Co-expressing GD2-specific CAR T-cells", "d": ["A preparation of autologous T-lymphocytes that have been genetically modified to express a chimeric antigen receptor (CAR) specific for the human tumor-associated antigen (TAA) GD2, and the constitutively active interleukin 7 (IL-7) receptor (C7R), with potential antineoplastic activity. Upon intravenous administration, autologous active IL-7 receptor co-expressing GD2-specific CAR T-cells target, bind to, and induce selective toxicity in GD2-expressing tumor cells. C7R triggers IL-7-mediated signaling that promotes T-cell proliferation, survival, and anti-tumor activity. GD2, a disialoganglioside and TAA, is overexpressed in a variety of tumor cell types."], "t": []}], "preferred_name": "Autologous Active IL-7 Receptor Co-expressing GD2-specific CAR T-cells", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:1001108", "l": "kidney loop of Henle medullary thick ascending limb epithelial cell", "d": ["An epithelial cell that is part of some loop of Henle thick ascending limb segment located in the renal medulla."], "t": []}], "preferred_name": "kidney loop of Henle medullary thick ascending limb epithelial cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5157444", "l": "CD3+CD4+CD45RO+ cells | Blood | Cell markers", "d": [], "t": []}], "preferred_name": "CD3+CD4+CD45RO+ cells | Blood | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5854314", "l": "Omisirge", "d": [], "t": []}], "preferred_name": "Omisirge", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4033001", "l": "endothelial cell of arteriole of lymph node", "d": ["A(n) endothelial cell that is part of a(n) arteriole of lymph node."], "t": []}], "preferred_name": "endothelial cell of arteriole of lymph node", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1517807", "l": "Leukemic Hematopoietic Stem Cell", "d": [], "t": []}, {"i": "NCIT:C41069", "l": "Leukemic Hematopoietic Stem Cell", "d": ["A malignant hematopoietic cell which may derive from mutations in normal hematopoietic stem cells. Leukemic hematopoietic stem cells can initiate or sustain neoplastic hematopoietic diseases because they are able to both proliferate and give rise to other malignant cells."], "t": []}], "preferred_name": "Leukemic Hematopoietic Stem Cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1440355", "l": "CD79a+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:732274004", "l": "", "d": [], "t": []}], "preferred_name": "CD79a+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5784931", "l": "Autologous Anti-ROR1 CAR-T Cells BMS-986403", "d": [], "t": []}, {"i": "NCIT:C192143", "l": "Autologous Anti-ROR1 CAR-T Cells BMS-986403", "d": ["A preparation of autologous T-lymphocytes genetically modified to express a chimeric antigen receptor (CAR) targeting the tumor-associated antigen (TAA) receptor tyrosine kinase-like orphan receptor 1 (ROR1), with potential immunomodulatory and antineoplastic activities. After isolation, transduction, expansion and reintroduction into the patient, the autologous anti-ROR1 CAR-T cells BMS-986403 are directed to, bind to, and induce selective toxicity in tumor cells expressing ROR1. ROR1, also known as neurotrophic tyrosine kinase, receptor-related 1 (NTRKR1), is expressed during embryogenesis and in various hematological and solid malignancies. It plays key roles in tumor cell proliferation and survival."], "t": []}], "preferred_name": "Autologous Anti-ROR1 CAR-T Cells BMS-986403", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5170957", "l": "Leukocytes other | Pleural fluid | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Leukocytes other | Pleural fluid | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": 85.53200374075534, "identifiers": [{"i": "UMLS:C1883279", "l": "Terminal Duct Cell", "d": [], "t": []}, {"i": "NCIT:C62170", "l": "Terminal Duct Cell", "d": [], "t": []}], "preferred_name": "Terminal Duct Cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1267942", "l": "Lymphocyte positive for CD50 antigen", "d": [], "t": []}, {"i": "SNOMEDCT:117385006", "l": "", "d": [], "t": []}], "preferred_name": "Lymphocyte positive for CD50 antigen", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0009030", "l": "enteroendocrine cell of appendix", "d": ["An intestinal enteroendocrine cell that is located in a vermiform appendix."], "t": []}], "preferred_name": "enteroendocrine cell of appendix", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1440419", "l": "Cells.t(X;18)(q11.2;p11.23)(SS18,SSX1)", "d": [], "t": []}], "preferred_name": "Cells.t(X;18)(q11.2;p11.23)(SS18,SSX1)", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0002473", "l": "MHC-II-high non-classical monocyte", "d": ["Gr1-low non-classical monocyte that has high surface expression of a MHC-II complex."], "t": []}], "preferred_name": "MHC-II-high non-classical monocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "CL:2000051", "l": "splenic fibroblast", "d": ["Any fibroblast that is part of a spleen."], "t": []}], "preferred_name": "splenic fibroblast", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4042010", "l": "pial interlaminar astrocyte", "d": ["An interlaminar astrocyte whose soma is part of the first layer of a neocortex and is in contact with a pia surface."], "t": []}], "preferred_name": "pial interlaminar astrocyte", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1440379", "l": "Cytoplasmic CD79+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:1373305004", "l": "", "d": [], "t": []}], "preferred_name": "Cytoplasmic CD79+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": 37.26275397368345, "identifiers": [{"i": "CL:0000034", "l": "stem cell", "d": ["A relatively undifferentiated cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells."], "t": []}], "preferred_name": "stem cell", "taxa": []}
{"type": "biolink:Cell", "ic": 87.18682603146104, "identifiers": [{"i": "CL:0000730", "l": "leading edge cell", "d": ["A cell at the front of a migrating epithelial sheet."], "t": []}], "preferred_name": "leading edge cell", "taxa": []}
{"type": "biolink:Cell", "ic": 76.22330125402472, "identifiers": [{"i": "CL:0000570", "l": "parafollicular cell", "d": ["A neuroepithelial cells that occurs singly or in small groups, close to the outer follicular borders but within the follicular basement membrane of the thyroid. This cell expresses a form of the neural cell adhesion molecule (N-CAM) on its surface and secretes calcitonin and serotonin (5-hydroxytryptamine)."], "t": []}, {"i": "UMLS:C0229579", "l": "Structure of thyroid parafollicular cell", "d": [], "t": []}, {"i": "NCIT:C33261", "l": "C-Cell", "d": ["A neuroendocrine cell found in the thyroid gland interspersed among the follicular cells or in clusters between the follicles. It produces and secretes calcitonin in response to its calcium receptor."], "t": []}, {"i": "SNOMEDCT:50552001", "l": "", "d": [], "t": []}], "preferred_name": "parafollicular cell", "taxa": []}
{"type": "biolink:Cell", "ic": 92.76600187037766, "identifiers": [{"i": "CL:0000342", "l": "pigment cell (sensu Vertebrata)", "d": ["Any animal cell containing pigment granules."], "t": []}], "preferred_name": "pigment cell (sensu Vertebrata)", "taxa": []}
{"type": "biolink:Cell", "ic": 90.871710685482, "identifiers": [{"i": "CL:0002179", "l": "foveolar cell of stomach", "d": ["A simple columnar cell that populates the entire luminal surface including the gastric pits. This cell types secrete mucus to form a thick protective, lubricant layer over the gastric wall."], "t": []}, {"i": "UMLS:C1267581", "l": "Gastric mucous gland neck cell", "d": [], "t": []}, {"i": "SNOMEDCT:110605001", "l": "", "d": [], "t": []}], "preferred_name": "foveolar cell of stomach", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5157545", "l": "CD4+CD45RA+CD45RB+CD45RC+ cells | Body fluid | Cell markers", "d": [], "t": []}], "preferred_name": "CD4+CD45RA+CD45RB+CD45RC+ cells | Body fluid | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "CL:0002211", "l": "type I muscle cell", "d": ["A slow muscle cell that has large amounts of myoglobin, stores energy as triglycerides, generates ATP by the oxidative method and is resistant to fatigue."], "t": []}], "preferred_name": "type I muscle cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0000760", "l": "type 8 cone bipolar cell (sensu Mus)", "d": ["An ON-bipolar neuron found in the retina and having connections with cone photoreceptors cells and neurons in the inner half of the inner plexiform layer. This cell has the widest dendritic field and the widest axon terminal of all retinal bipolar cells. The axon terminal is delicate and stratified through sublaminae 4 and 5 of the inner plexiform layer."], "t": []}], "preferred_name": "type 8 cone bipolar cell (sensu Mus)", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5180577", "l": "Segmented neutrophils | Peritoneal fluid | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Segmented neutrophils | Peritoneal fluid | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1954324", "l": "Leukocytes+Platelets", "d": [], "t": []}], "preferred_name": "Leukocytes+Platelets", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C6052709", "l": "Allogeneic Anti-CD123 CAR-T Cells", "d": [], "t": []}, {"i": "NCIT:C219707", "l": "Allogeneic Anti-CD123 CAR-T Cells", "d": ["A preparation of allogeneic T-cells engineered to express a chimeric antigen receptor (CAR) specific for the tumor-associated antigen (TAA) CD123 (interleukin-3 receptor alpha chain or IL3RA), with potential immunostimulating and antineoplastic activities. Upon administration, the allogeneic anti-CD123 CAR-T cells target and bind to CD123 expressed on the surface of tumor cells. This induces selective toxicity in CD123-expressing tumor cells. CD123, the alpha subunit of the IL-3 receptor, regulates the proliferation, survival and differentiation of hematopoietic cells. It is overexpressed on a variety of cancers, including myeloid leukemia, and the increased expression of CD123 on leukemic stem cells (LSCs) is associated with poor prognosis."], "t": []}], "preferred_name": "Allogeneic Anti-CD123 CAR-T Cells", "taxa": []}
{"type": "biolink:Cell", "ic": 82.62268137420203, "identifiers": [{"i": "UMLS:C1516949", "l": "Epithelioid Melanocyte", "d": [], "t": []}, {"i": "NCIT:C36870", "l": "Epithelioid Melanocyte", "d": [], "t": []}], "preferred_name": "Epithelioid Melanocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 84.83823963392128, "identifiers": [{"i": "UMLS:C0018894", "l": "Helper-Inducer T-Lymphocyte", "d": [], "t": []}, {"i": "NCIT:C12538", "l": "Helper-Inducer T-Lymphocyte", "d": ["A subtype of CD4+ T lymphocyte that triggers differentiation of nearby immune cells, and initiates a variety of other immune functions, including the induction of humoral and cellular inflammatory immune responses by B and other T lymphocytes, respectively."], "t": []}, {"i": "MESH:D006377", "l": "T-Lymphocytes, Helper-Inducer", "d": [], "t": []}, {"i": "SNOMEDCT:29594005", "l": "", "d": [], "t": []}, {"i": "SNOMEDCT:7944005", "l": "", "d": [], "t": []}], "preferred_name": "Helper-Inducer T-Lymphocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4033140", "l": "ciliary ganglion TH neuron", "d": ["A parasympathetic neuron that has the soma located in the ciliary ganglion and expresses the marker tyrosine hydroxylase (TH)."], "t": []}], "preferred_name": "ciliary ganglion TH neuron", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5908026", "l": "iPSC-derived Allogeneic Anti-HER2 CAR T-cells FT825", "d": [], "t": []}], "preferred_name": "iPSC-derived Allogeneic Anti-HER2 CAR T-cells FT825", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0020066", "l": "myoepithelial cell of salivary gland", "d": ["A myoepithelial cell that is part of a salivary gland, positioned between the basal lamina and the secretory or ductal epithelial cells surrounding acini and intercalated ducts. This cell adopts a stellate morphology with four to eight cellular processes around acini and an elongated form parallel to the ductal axis around intercalated ducts (Amano et al., 2012). It expresses alpha-smooth muscle actin (ACTA2/alpha-SMA) as a primary marker, along with p63 and aquaporin 1 (AQP1), and contracts rhythmically in response to neural stimulation to facilitate saliva expulsion from secretory acini into the ductal system (Amano et al., 2012). This cell also produces FGF7, which activates FGFR2b-dependent transcriptional programs essential for seromucous acinar cell differentiation (Aure et al., 2023). In mice, myoepithelial cells express SOX2 and possess regenerative capacity, contributing to acinar cell restoration during tissue repair after severe injury."], "t": []}], "preferred_name": "myoepithelial cell of salivary gland", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1267918", "l": "Lymphocyte positive for CD41 antigen", "d": [], "t": []}, {"i": "SNOMEDCT:117586008", "l": "", "d": [], "t": []}], "preferred_name": "Lymphocyte positive for CD41 antigen", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1135969", "l": "Large Luteal Cells", "d": [], "t": []}, {"i": "NCIT:C32693", "l": "Granulosa Lutein Cell", "d": ["A cell of the corpus luteum of the ovary that is derived from the granulosa cells of the preovulatory follicle; it secretes progesterone and estrogen."], "t": []}], "preferred_name": "Large Luteal Cells", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C2736934", "l": "CD5+FMC7+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:1373148002", "l": "", "d": [], "t": []}], "preferred_name": "CD5+FMC7+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C6050356", "l": "Anti-GARP Chimeric Antigen Receptor-T Cells", "d": [], "t": []}, {"i": "NCIT:C216252", "l": "Anti-GARP Chimeric Antigen Receptor-T Cells", "d": ["A preparation of T-lymphocytes engineered to express a chimeric antigen receptor (CAR) targeting the tumor-associated antigen (TAA) and transforming growth factor beta (TGFbeta) activator glycoprotein A repetitions predominant (GARP; leucine-rich repeat-containing protein 32; LRRC32), with potential antineoplastic activity. Upon administration, anti-GARP CAR-T cells recognize, bind to and kill GARP-expressing tumor cells. GARP is widely expressed by a variety of human cancer cells compared with normal, healthy cells."], "t": []}], "preferred_name": "Anti-GARP Chimeric Antigen Receptor-T Cells", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C2359895", "l": "Platelets.reticulated", "d": [], "t": []}], "preferred_name": "Platelets.reticulated", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C0085262", "l": "PC12 Cells", "d": [], "t": []}, {"i": "NCIT:C17435", "l": "PC-12", "d": ["PC-12 adheres poorly to plastic, and tends to grow in small clusters. Attachment is improved by using collagen coated flasks."], "t": []}, {"i": "MESH:D016716", "l": "PC12 Cells", "d": [], "t": []}], "preferred_name": "PC12 Cells", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4722715", "l": "S68587", "d": [], "t": []}], "preferred_name": "S68587", "taxa": []}
{"type": "biolink:Cell", "ic": 77.38833137893549, "identifiers": [{"i": "CL:4023095", "l": "untufted pyramidal neuron", "d": ["A pyramidal neuron which lacks a clear tuft formation but extends to large radial distances."], "t": []}], "preferred_name": "untufted pyramidal neuron", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5154483", "l": "Basophils | Synovial fluid | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Basophils | Synovial fluid | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": 92.76600187037766, "identifiers": [{"i": "CL:1000490", "l": "mesothelial cell of peritoneum", "d": ["A mesothelial cell that is part of the peritoneum."], "t": []}], "preferred_name": "mesothelial cell of peritoneum", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0009075", "l": "myo-medullary thymic epithelial cell", "d": ["A thymic medullary epithelial cell that expresses muscle-specific biomarkers."], "t": []}], "preferred_name": "myo-medullary thymic epithelial cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5157308", "l": "CD14 blasts | Bone marrow | Cell markers", "d": [], "t": []}], "preferred_name": "CD14 blasts | Bone marrow | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5175150", "l": "Nucleated cells | Dialysis fluid | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Nucleated cells | Dialysis fluid | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:1000456", "l": "mesothelial cell of parietal peritoneum", "d": ["A mesothelial cell that is part of the parietal peritoneum."], "t": []}, {"i": "UMLS:C1183326", "l": "Mesothelial cell of parietal peritoneum", "d": [], "t": []}], "preferred_name": "mesothelial cell of parietal peritoneum", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0009055", "l": "paneth cell of anorectum", "d": ["A paneth cell that is located in the anorectum."], "t": []}], "preferred_name": "paneth cell of anorectum", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4697032", "l": "CD38+IgM+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:1373155000", "l": "", "d": [], "t": []}], "preferred_name": "CD38+IgM+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0003038", "l": "M7-OFF retinal ganglion cell", "d": ["An M7 retinal ganglion cells with synaptic terminals in S2 and is depolarized by decreased illumination of their receptive field center"], "t": []}], "preferred_name": "M7-OFF retinal ganglion cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0882804", "l": "CD16c+CD56+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:1372973008", "l": "", "d": [], "t": []}], "preferred_name": "CD16c+CD56+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": 89.40238429118027, "identifiers": [{"i": "CL:0000768", "l": "immature basophil", "d": ["Any of the immature forms of a basophil, in which basophilic specific granules are present but other phenotypic features of the mature form may be lacking."], "t": []}], "preferred_name": "immature basophil", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5776716", "l": "Monocytes.CD14+CD16-", "d": [], "t": []}], "preferred_name": "Monocytes.CD14+CD16-", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5977365", "l": "CD3-CD14+CD45+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:1373221007", "l": "", "d": [], "t": []}], "preferred_name": "CD3-CD14+CD45+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4033077", "l": "cycling alveolar macrophage", "d": ["A(n) alveolar macrophage that is cycling."], "t": []}], "preferred_name": "cycling alveolar macrophage", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0920441", "l": "circulating cancer cell", "d": [], "t": []}], "preferred_name": "circulating cancer cell", "taxa": []}
{"type": "biolink:Cell", "ic": 92.76600187037766, "identifiers": [{"i": "CL:0002386", "l": "multinucleate macroconidium", "d": ["A macroconidium that has more than one nucleus."], "t": []}], "preferred_name": "multinucleate macroconidium", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:1000444", "l": "mesothelial cell of anterior chamber of eye", "d": ["A mesothelial cell that is part of the anterior chamber of eyeball."], "t": []}, {"i": "UMLS:C1182655", "l": "Mesothelial cell of anterior chamber of eye", "d": [], "t": []}], "preferred_name": "mesothelial cell of anterior chamber of eye", "taxa": []}
{"type": "biolink:Cell", "ic": 75.54735764213513, "identifiers": [{"i": "UMLS:C1510717", "l": "Abnormal Cytotrophoblastic Cell", "d": [], "t": []}, {"i": "NCIT:C36801", "l": "Abnormal Cytotrophoblastic Cell", "d": [], "t": []}], "preferred_name": "Abnormal Cytotrophoblastic Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 75.876659701315, "identifiers": [{"i": "CL:2000074", "l": "splenocyte", "d": ["Any leukocyte that is part of a spleen."], "t": []}], "preferred_name": "splenocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0002183", "l": "stem cell of gastric gland", "d": ["A stomach epithelial cell that is olumnar in form with a few short apical microvilli; relatively undifferentiated mitotic cell from which other types of gland are derived; few in number, situated in the isthmus region of the gland and base of the gastric pit."], "t": []}, {"i": "UMLS:C1179475", "l": "Stem cell of gastric gland", "d": [], "t": []}], "preferred_name": "stem cell of gastric gland", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1267996", "l": "Lymphocyte positive for CD117 antigen", "d": [], "t": []}, {"i": "SNOMEDCT:117436000", "l": "", "d": [], "t": []}], "preferred_name": "Lymphocyte positive for CD117 antigen", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:2000015", "l": "fibroblast of arm", "d": ["Any skin fibroblast that is part of a arm."], "t": []}], "preferred_name": "fibroblast of arm", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:2000066", "l": "cardiac ventricle fibroblast", "d": ["Any fibroblast that is part of a cardiac ventricle."], "t": []}], "preferred_name": "cardiac ventricle fibroblast", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C4733641", "l": "KITE-585", "d": [], "t": []}, {"i": "NCIT:C155883", "l": "Autologous Anti-BCMA CAR-transduced T-cells KITE-585", "d": ["A preparation of autologous T-lymphocytes that have been genetically modified to express a chimeric antigen receptor (CAR) containing a single chain variable fragment (scFv) derived from a human monoclonal antibody specific for the human tumor-associated antigen (TAA) B-cell maturation antigen (BCMA; tumor necrosis factor receptor superfamily member 17; TNFRSF17) fused, via an as of yet unknown linker, to the co-stimulatory domain of CD28, with potential immunostimulating and antineoplastic activities. Upon administration, the autologous anti-BCMA CAR transduced T-cells KITE-585 specifically recognize and induce selective toxicity in BCMA-expressing tumor cells. BCMA, a receptor for both a proliferation-inducing ligand (APRIL) and B-cell activating factor (BAFF), is a member of the tumor necrosis factor receptor superfamily (TNFRSF). BCMA is found on the surfaces of plasma cells, is overexpressed on malignant plasma cells and plays a key role in plasma cell proliferation and survival. The CD28 co-stimulatory domain optimizes T-cell expansion and function."], "t": []}], "preferred_name": "KITE-585", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:1001107", "l": "kidney loop of Henle thin ascending limb epithelial cell", "d": ["An epithelial cell that is part of some loop of Henle thin ascending limb."], "t": []}], "preferred_name": "kidney loop of Henle thin ascending limb epithelial cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1514657", "l": "RL13", "d": [], "t": []}, {"i": "NCIT:C20291", "l": "RL13", "d": ["Provider: Reliance Life Sciences, Mumbai, India. No information from provider. This cell line meets the criteria for the use of human embryonic stem cells by federally funded researchers."], "t": []}], "preferred_name": "RL13", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5177451", "l": "Plasma cell precursor | Blood | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Plasma cell precursor | Blood | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C4053532", "l": "Circulating Epithelial Cell", "d": [], "t": []}, {"i": "NCIT:C122733", "l": "Circulating Epithelial Cell", "d": ["A cell derived from an epithelial membrane that is found in the blood. These cells are associated with epithelial-mesenchymal transition and may be markers for neoplastic diseases."], "t": []}], "preferred_name": "Circulating Epithelial Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5557247", "l": "Anti-CAIX CAR T Cells", "d": [], "t": []}, {"i": "NCIT:C181752", "l": "Anti-CAIX CAR T Cells", "d": ["A preparation of T-lymphocytes that have been genetically modified to express a chimeric antigen receptor (CAR) targeting the tumor-associated antigen (TAA) carbonic anhydrase IX (CAIX; carbonic anhydrase 9; CA9; G250), with potential immunostimulating and antineoplastic activities. Upon administration, anti-CAIX CAR T-cells target and bind to CAIX-expressing tumor cells, thereby inducing selective toxicity in CAIX-expressing tumor cells. CAIX is a member of the carbonic anhydrase family that is found in a majority of renal cell carcinomas while absent in most normal tissues."], "t": []}], "preferred_name": "Anti-CAIX CAR T Cells", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4267790", "l": "CD27+CD45RA+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:1373001001", "l": "", "d": [], "t": []}], "preferred_name": "CD27+CD45RA+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": 67.22985628720302, "identifiers": [{"i": "CL:0000036", "l": "epithelial fate stem cell", "d": ["A somatic stem cell that is committed to an epithelial fate, possessing the capacity for self-renewal and the ability to differentiate into one or more distinct mature cell types of the epithelial lineage. This cell is crucial for the development, homeostasis, repair, and regeneration of epithelial tissues."], "t": []}], "preferred_name": "epithelial fate stem cell", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "UMLS:C1517690", "l": "LH Cells", "d": [], "t": []}, {"i": "NCIT:C32985", "l": "LH Cell", "d": ["A luteinizing hormone secreting cell found in the anterior pituitary gland."], "t": []}], "preferred_name": "LH Cells", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5706400", "l": "Autologous HBV-specific TCR-expressing T-lymphocytes SCG101", "d": [], "t": []}, {"i": "NCIT:C187331", "l": "Autologous HBV-specific TCR-expressing T-lymphocytes SCG101", "d": ["A preparation of human autologous T-lymphocytes transduced with a retroviral vector encoding for a T-cell receptor (TCR) specific for HLA-A*02-restricted human hepatitis B virus (HBV) surface antigen (HBsAg) peptide, with potential antineoplastic activity. Upon administration, the autologous HBV-specific TCR-expressing T-lymphocytes SCG101 recognize and bind to HBV antigen-positive cells, which induces cytotoxic T-lymphocyte (CTL)-mediated elimination of HBV antigen-positive cells, including those in HBV-related hepatocellular carcinoma (HCC)."], "t": []}], "preferred_name": "Autologous HBV-specific TCR-expressing T-lymphocytes SCG101", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5708808", "l": "Cloud Vitreous Seed", "d": [], "t": []}, {"i": "NCIT:C189884", "l": "Cloud Vitreous Seed", "d": ["A histopathologic classification of vitreous seeding that is characterized by diffuse, dense collections of tumor cells."], "t": []}], "preferred_name": "Cloud Vitreous Seed", "taxa": []}
{"type": "biolink:Cell", "ic": 70.22551955196433, "identifiers": [{"i": "CL:4023060", "l": "hippocampal CA1-3 neuron", "d": ["A neuron that has its soma located in CA1-3 of the hippocampus."], "t": []}], "preferred_name": "hippocampal CA1-3 neuron", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4518173", "l": "Population of all pitted erythrocytes in portion of fluid", "d": [], "t": []}, {"i": "SNOMEDCT:725388003", "l": "", "d": [], "t": []}], "preferred_name": "Population of all pitted erythrocytes in portion of fluid", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5216268", "l": "Metamyelocytes|NCnc|Pt|Body fld", "d": [], "t": []}], "preferred_name": "Metamyelocytes|NCnc|Pt|Body fld", "taxa": []}
{"type": "biolink:Cell", "ic": 85.53200374075534, "identifiers": [{"i": "CL:0000530", "l": "primary neuron (sensu Teleostei)", "d": ["A neuron that develops during the early segmentation stages in teleosts, before the neural tube is formed."], "t": []}], "preferred_name": "primary neuron (sensu Teleostei)", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5443441", "l": "lisocabtagene maraleucel, CD4 component, 2 of 2", "d": [], "t": []}], "preferred_name": "lisocabtagene maraleucel, CD4 component, 2 of 2", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4329802", "l": "Ex Vivo-expanded Autologous T Cells IMA101", "d": [], "t": []}], "preferred_name": "Ex Vivo-expanded Autologous T Cells IMA101", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5216208", "l": "Erythrocytes.nucleated|NCnc|Pt|CSF", "d": [], "t": []}], "preferred_name": "Erythrocytes.nucleated|NCnc|Pt|CSF", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C4744618", "l": "Autologous Anti-CD19CAR-CD3zeta-4-1BB-IL-15-PD1-expressing Tri-functional T-lymphocytes", "d": [], "t": []}, {"i": "NCIT:C156169", "l": "Autologous Anti-CD19CAR-CD3zeta-4-1BB-IL-15-PD1-expressing Tri-functional T-lymphocytes", "d": ["A preparation of autologous T-lymphocytes engineered to express a tri-functional chimeric antigen receptor (CAR) specific for the tumor-associated antigen (TAA) cluster of differentiation 19 (CD19), and an extracellular domain consisting of interleukin 15 (IL-15) and programmed cell death 1 (PD1; PDCD1; CD279; programmed death-1), linked to the intracellular signaling domains of 4-1BB (CD137) and the zeta chain of the TCR/CD3 complex (TCRzeta; CD247; CD3zeta), with potential antineoplastic activity. Upon intravenous administration, autologous anti-CD19CAR-CD3zeta-4-1BB-IL-15-PD1-expressing tri-functional T-lymphocytes target, bind to, and induce selective toxicity in CD19-expressing tumor cells. IL-15 is a pro-survival cytokine that promotes T-cell persistence and potentiates the immune response against tumor cells. The PD1 moiety binds to programmed cell death-1 ligand 1 (PD-L1; cluster of differentiation 274; CD274) on tumor cells, reversing T-cell inactivation caused by endogenous PD1/PD-L1 signaling and enhancing the cytotoxic T-lymphocyte (CTL)-mediated anti-tumor immune response against PD-L1-expressing tumor cells. CD19 is a B-cell-specific cell surface antigen overexpressed in B-cell lineage tumors. Incorporation of the costimulatory signaling domains increases human T-cell function, expansion, and survival."], "t": []}], "preferred_name": "Autologous Anti-CD19CAR-CD3zeta-4-1BB-IL-15-PD1-expressing Tri-functional T-lymphocytes", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5785511", "l": "Pooled Cell Specimen", "d": [], "t": []}, {"i": "NCIT:C193001", "l": "Pooled Cell Specimen", "d": ["A biospecimen consisting of cells that were collected from multiple donors and then cultured together."], "t": []}], "preferred_name": "Pooled Cell Specimen", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5180817", "l": "Sezary cells | Blood | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Sezary cells | Blood | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5163720", "l": "Erythrocytes | Pericardial fluid | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Erythrocytes | Pericardial fluid | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "NCIT:C32734", "l": "Hepatic Stellate Cell", "d": ["A star-shaped cell in the liver associated with the development of fibrosis. When stellate cells are activated in response to an injury, they proliferate and synthesize large amounts of extracellular matrix which results in deposition of scar or fibrous tissue."], "t": []}], "preferred_name": "Hepatic Stellate Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 73.613037951824, "identifiers": [{"i": "CL:0000814", "l": "mature NK T cell", "d": ["A mature alpha-beta T cell of a distinct lineage that bears natural killer markers and a T cell receptor specific for a limited set of ligands. NK T cells have activation and regulatory roles particularly early in an immune response."], "t": []}], "preferred_name": "mature NK T cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4052042", "l": "tuft cell of urethra", "d": ["A tuft cell that is part of the epithelium of the urethra. This cell monitors urethral contents by detecting chemical stimuli, such as bitter compounds and sugars. Upon activation, it stimulates sensory nerve fibres and triggers detrusor muscle contraction, likely aiding in pathogen clearance by promoting bladder emptying."], "t": []}], "preferred_name": "tuft cell of urethra", "taxa": []}
{"type": "biolink:Cell", "ic": 54.14969971339225, "identifiers": [{"i": "UMLS:C1449624", "l": "Neuroepithelial Cells", "d": [], "t": []}, {"i": "NCIT:C41410", "l": "Neuroepithelial Cell", "d": ["A neural stem cell that can give rise to radial glial progenitor cells which through subsequent divisions may generate neurons or mature glial cells. This may also refer to the specialized sensory epithelial cells of the olfactory, gustatory, and vestibulocochlear receptor systems."], "t": []}, {"i": "MESH:D046569", "l": "Neuroepithelial Cells", "d": [], "t": []}], "preferred_name": "Neuroepithelial Cells", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:1000300", "l": "fibroblast of outer membrane of prostatic capsule", "d": ["A fibroblast that is part of the outer membrane of prostatic capsule."], "t": []}, {"i": "UMLS:C2329916", "l": "Fibroblast of outer membrane of prostatic capsule", "d": [], "t": []}], "preferred_name": "fibroblast of outer membrane of prostatic capsule", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:2000085", "l": "mononuclear cell of umbilical cord", "d": ["Any mononuclear cell that is part of a umbilical cord."], "t": []}], "preferred_name": "mononuclear cell of umbilical cord", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5881765", "l": "Lyfgenia", "d": [], "t": []}, {"i": "MESH:C000729928", "l": "", "d": [], "t": []}], "preferred_name": "Lyfgenia", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4307050", "l": "Astro-TE NN_5 Adamts18 astrocyte (Mmus)", "d": ["A astrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of S1pr1 (Mmus), Adamts18 (Mmus), Crym (Mmus). It is distinguished from other Astro-TE NN_5 cells by expression of Adamts18. These cells are located in the Lateral septal complex, Striatum dorsal region, brain , in or close to the regions: Nucleus accumbens, Caudoputamen, lateral ventricle . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5230 Astro-TE NN_5."], "t": []}], "preferred_name": "Astro-TE NN_5 Adamts18 astrocyte (Mmus)", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5447474", "l": "lovotibeglogene autotemcel", "d": [], "t": []}], "preferred_name": "lovotibeglogene autotemcel", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5157288", "l": "CD126 blasts | XXX | Cell markers", "d": [], "t": []}], "preferred_name": "CD126 blasts | XXX | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1522214", "l": "Mouse Beta Cell", "d": [], "t": []}, {"i": "NCIT:C22642", "l": "Mouse Beta Cell", "d": [], "t": []}], "preferred_name": "Mouse Beta Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "CL:0002344", "l": "CD56-negative, CD161-positive immature natural killer cell, human", "d": ["A natural killer cell that is developmentally immature, has the phenotype CD34-negative, CD56-negative, CD117-positive, CD122-positive,and CD161-positive."], "t": []}], "preferred_name": "CD56-negative, CD161-positive immature natural killer cell, human", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4307088", "l": "OPC NN_1 Mms22l oligodendrocyte precursor cell (Mmus)", "d": ["A oligodendrocyte precursor cell of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Pdgfra (Mmus), Olig1 (Mmus), Mms22l (Mmus), Top2a (Mmus). It is distinguished from other OPC NN_1 cells by expression of Mms22l, Foxg1, Top2a. These cells are located in the Isocortex, Olfactory areas, brain . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5268 OPC NN_1."], "t": []}], "preferred_name": "OPC NN_1 Mms22l oligodendrocyte precursor cell (Mmus)", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4696002", "l": "CD3+CD4+CD27+CD45RO+CD62L+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:1373247003", "l": "", "d": [], "t": []}], "preferred_name": "CD3+CD4+CD27+CD45RO+CD62L+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5427570", "l": "Cones.left", "d": [], "t": []}], "preferred_name": "Cones.left", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0002296", "l": "type-4 epithelial cell of thymus", "d": ["An epithelial cell with high nuclear and cytoplasmic electron-density. This cell type is found in the deeper portions of the cortex but is more abundant in the medulla of the thymus."], "t": []}, {"i": "UMLS:C1183360", "l": "Type-4 epithelial cell of thymus", "d": [], "t": []}], "preferred_name": "type-4 epithelial cell of thymus", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1956051", "l": "Hair Cells, Ampulla", "d": [], "t": []}, {"i": "MESH:D054777", "l": "Hair Cells, Ampulla", "d": [], "t": []}], "preferred_name": "Hair Cells, Ampulla", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0005013", "l": "single ciliated epithelial cell", "d": ["A ciliated epithelial cell with a single cilium."], "t": []}], "preferred_name": "single ciliated epithelial cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5157948", "l": "Cells other than spermatozoa | Semen | Fertility testing", "d": [], "t": []}], "preferred_name": "Cells other than spermatozoa | Semen | Fertility testing", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1717811", "l": "Filamented Erythrocyte", "d": [], "t": []}, {"i": "NCIT:C206358", "l": "Filamented Erythrocyte", "d": ["An abnormal red blood cell with a tennis racket or long tail-shape."], "t": []}], "preferred_name": "Filamented Erythrocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5669564", "l": "Nivadstrocel", "d": [], "t": []}, {"i": "NCIT:C184825", "l": "Nivadstrocel", "d": [], "t": []}], "preferred_name": "Nivadstrocel", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0004233", "l": "DAPI-3 amacrine cell", "d": ["An amacrine cell with a medium dendritic field and post-synaptic terminals that stratify at S2, with a second stratification that occurs in S3 and S4. This cell type releases the neurotransmitter glycine."], "t": []}], "preferred_name": "DAPI-3 amacrine cell", "taxa": []}
{"type": "biolink:Cell", "ic": 87.18682603146104, "identifiers": [{"i": "UMLS:C1514004", "l": "Neoplastic T-Cell Large Granular Lymphocyte", "d": [], "t": []}, {"i": "NCIT:C37019", "l": "Neoplastic T-Cell Large Granular Lymphocyte", "d": [], "t": []}], "preferred_name": "Neoplastic T-Cell Large Granular Lymphocyte", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5178162", "l": "Primary Spermatocytes | Semen | Fertility testing", "d": [], "t": []}], "preferred_name": "Primary Spermatocytes | Semen | Fertility testing", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0002600", "l": "smooth muscle cell of trachea", "d": ["A smooth muscle cell of the trachea."], "t": []}], "preferred_name": "smooth muscle cell of trachea", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4052001", "l": "multiciliated ependymal cell", "d": ["An ependymal cell that lines the lateral, third, and fourth ventricles of the brain. The cell is characterized by multiple motile cilia on its apical surface, which beats in a coordinated manner to facilitate the movement of cerebrospinal fluid (CSF), contributing to brain homeostasis."], "t": []}], "preferred_name": "multiciliated ependymal cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0000918", "l": "Tc2 cell", "d": ["A CD8-positive, alpha-beta positive T cell expressing GATA-3 and secreting IL-4."], "t": []}], "preferred_name": "Tc2 cell", "taxa": []}
{"type": "biolink:Cell", "ic": 70.51821968886674, "identifiers": [{"i": "UMLS:C1515966", "l": "Anaplastic Large Lymphocyte", "d": [], "t": []}, {"i": "NCIT:C37018", "l": "Anaplastic Large Lymphocyte", "d": [], "t": []}], "preferred_name": "Anaplastic Large Lymphocyte", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C2324444", "l": "Set of adrenergic cells in anterior reticular nucleus [C2]", "d": [], "t": []}], "preferred_name": "Set of adrenergic cells in anterior reticular nucleus [C2]", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5572421", "l": "Deep transitional cells | Urine sediment | Urinalysis", "d": [], "t": []}], "preferred_name": "Deep transitional cells | Urine sediment | Urinalysis", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "CL:1000245", "l": "posterior lateral line ganglion neuron", "d": ["Any peripheral nervous system neuron that has its soma located in some posterior lateral line ganglion."], "t": []}], "preferred_name": "posterior lateral line ganglion neuron", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5167747", "l": "HLA-B27 cells | Blood | Cell markers", "d": [], "t": []}], "preferred_name": "HLA-B27 cells | Blood | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5216285", "l": "Neutrophils.band form|NCnc|Pt|Bld", "d": [], "t": []}], "preferred_name": "Neutrophils.band form|NCnc|Pt|Bld", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4524911", "l": "PLX-R18", "d": [], "t": []}], "preferred_name": "PLX-R18", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0205878", "l": "Glomus tympanicum", "d": [], "t": []}, {"i": "MESH:D043485", "l": "Glomus Tympanicum", "d": [], "t": []}, {"i": "SNOMEDCT:181381004", "l": "", "d": [], "t": []}], "preferred_name": "Glomus tympanicum", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4697028", "l": "Cells.CD28+HLA DR+", "d": [], "t": []}], "preferred_name": "Cells.CD28+HLA DR+", "taxa": []}
{"type": "biolink:Cell", "ic": 92.76600187037766, "identifiers": [{"i": "CL:4023162", "l": "bushy cell", "d": ["A neuron found in the anterior part of the ventral cochlear nucleus that has the appearance of bushes, having short dendrites. Bushy cells give outputs to different parts of the superior olivary complex."], "t": []}], "preferred_name": "bushy cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C2709114", "l": "CD138+kappa+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:1376043004", "l": "", "d": [], "t": []}], "preferred_name": "CD138+kappa+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:1000288", "l": "myocyte of atrial branch of anterior internodal tract", "d": ["A muscle cell that is part of the atrial branch of anterior internodal tract."], "t": []}, {"i": "UMLS:C2339058", "l": "Myocyte of atrial branch of anterior internodal tract", "d": [], "t": []}], "preferred_name": "myocyte of atrial branch of anterior internodal tract", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5216290", "l": "Neutrophils|NCnc|Pt|Bld", "d": [], "t": []}], "preferred_name": "Neutrophils|NCnc|Pt|Bld", "taxa": []}
{"type": "biolink:Cell", "ic": 77.38833137893549, "identifiers": [{"i": "UMLS:C5960957", "l": "Therapeutic Mesenchymal Stromal Cells", "d": [], "t": []}, {"i": "NCIT:C208118", "l": "Therapeutic Mesenchymal Stromal Cells", "d": ["Any preparation of mesenchymal stromal cells."], "t": []}], "preferred_name": "Therapeutic Mesenchymal Stromal Cells", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4079035", "l": "thoracic dorsal root ganglion RET neuron", "d": ["A non-peptidergic nociceptor whose soma is located in the thoracic dorsal root ganglion and that expresses the receptor tyrosine kinase RET (encoded by RET). This neuron is distinguished from peptidergic nociceptors by its dependence on glial cell-derived neurotrophic factor family ligands rather than nerve growth factor, and in rodents it characteristically binds isolectin B4. In human DRG, RET-immunoreactive neurons constitute approximately 46% of TrkA-positive neurons, a significantly higher proportion than the 23% observed in mouse (Rostock et al. 2018, PMID:29229553), indicating an expanded non-peptidergic nociceptor compartment in humans."], "t": []}], "preferred_name": "thoracic dorsal root ganglion RET neuron", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1440240", "l": "CD107b+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:1372821008", "l": "", "d": [], "t": []}], "preferred_name": "CD107b+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5977929", "l": "Granulocytes | Pleural fluid | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Granulocytes | Pleural fluid | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": 89.40238429118027, "identifiers": [{"i": "CL:0020017", "l": "M0 macrophage", "d": ["A macrophage that has not yet undergone polarization into a specific macrophage subtype. These cells are non-activated and have the potential to differentiate into inflammatory (M1) or alternatively activated (M2) macrophage subtypes in response to appropriate stimuli."], "t": []}], "preferred_name": "M0 macrophage", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1440346", "l": "CD66d+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:1372924004", "l": "", "d": [], "t": []}], "preferred_name": "CD66d+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": 84.83823963392128, "identifiers": [{"i": "UMLS:C5856864", "l": "Anti-CD30 CAR T Cells Preparation", "d": [], "t": []}, {"i": "NCIT:C201513", "l": "Anti-CD30 CAR T Cells Preparation", "d": ["A preparation of T-lymphocytes that express a chimeric antigen receptor (CAR) targeting the tumor-associated antigen (TAA) CD30."], "t": []}], "preferred_name": "Anti-CD30 CAR T Cells Preparation", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1522587", "l": "Mouse Eosinophil", "d": [], "t": []}, {"i": "NCIT:C22592", "l": "Mouse Eosinophil", "d": [], "t": []}], "preferred_name": "Mouse Eosinophil", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5784907", "l": "Autologous Anti-HLA-G CAR-T Cells IVS-3001", "d": [], "t": []}, {"i": "NCIT:C192117", "l": "Autologous Anti-HLA-G CAR-T Cells IVS-3001", "d": ["A preparation of autologous T-lymphocytes that have been genetically modified to express a chimeric antigen receptor (CAR) specific for the tumor-associated antigen (TAA) and immune checkpoint protein human leukocyte antigen G (HLA-G), with potential immune checkpoint inhibiting, immunomodulating and antineoplastic activities. Upon administration, autologous anti-HLA-G CAR-T cells IVS-3001 specifically recognize and kill HLA-G-expressing tumor cells. This reverts HLA-G-mediated immune suppression in the tumor microenvironment (TME), thereby restoring anti-tumor immune responses. HLA-G, an immune checkpoint normally expressed at the maternal-fetal interface, is expressed across multiple tumor types and plays a key role in cancer immune evasion. It inhibits immune responses by binding to its inhibitory receptors on a variety of immune cells, such as natural killer cells (NKs), T- and B-lymphocytes, and dendritic cells (DCs)."], "t": []}], "preferred_name": "Autologous Anti-HLA-G CAR-T Cells IVS-3001", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5707892", "l": "Olitresgene Autoleucel", "d": [], "t": []}, {"i": "NCIT:C188588", "l": "Olitresgene Autoleucel", "d": [], "t": []}], "preferred_name": "Olitresgene Autoleucel", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1513175", "l": "Metaplastic Myoepithelial Cell", "d": [], "t": []}, {"i": "NCIT:C37168", "l": "Metaplastic Myoepithelial Cell", "d": [], "t": []}], "preferred_name": "Metaplastic Myoepithelial Cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4528643", "l": "Kymriah", "d": [], "t": []}], "preferred_name": "Kymriah", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0000078", "l": "peridermal cell", "d": ["Any squamous epithelial cell that is part of some periderm."], "t": []}], "preferred_name": "peridermal cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5908028", "l": "ONO 8250", "d": [], "t": []}], "preferred_name": "ONO 8250", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "UMLS:C1513125", "l": "Meningothelial Cell with Elongated Processes", "d": [], "t": []}, {"i": "NCIT:C37157", "l": "Meningothelial Cell with Elongated Processes", "d": [], "t": []}], "preferred_name": "Meningothelial Cell with Elongated Processes", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5553343", "l": "allogeneic cultured keratinocytes and dermal fibroblasts in murine collagen-dsat", "d": [], "t": []}], "preferred_name": "allogeneic cultured keratinocytes and dermal fibroblasts in murine collagen-dsat", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5161800", "l": "Cytoplasmic CD22 blasts | XXX | Cell markers", "d": [], "t": []}], "preferred_name": "Cytoplasmic CD22 blasts | XXX | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": 92.76600187037766, "identifiers": [{"i": "CL:0000444", "l": "obliquely striated muscle cell", "d": ["A muscle cell in which the fibers are organised into sarcomeres but in which adjacent myofibrils are offset from each other, producing an oblique banding pattern."], "t": []}], "preferred_name": "obliquely striated muscle cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4322824", "l": "CD40+ B lymphocyte", "d": [], "t": []}], "preferred_name": "CD40+ B lymphocyte", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1440276", "l": "Cell negative for CD27 antigen", "d": [], "t": []}, {"i": "SNOMEDCT:1373162009", "l": "", "d": [], "t": []}], "preferred_name": "Cell negative for CD27 antigen", "taxa": []}
{"type": "biolink:Cell", "ic": 83.63771255585968, "identifiers": [{"i": "UMLS:C1709191", "l": "Neoplastic Parathyroid Gland Clear Cell", "d": [], "t": []}, {"i": "NCIT:C48279", "l": "Neoplastic Parathyroid Gland Clear Cell", "d": [], "t": []}], "preferred_name": "Neoplastic Parathyroid Gland Clear Cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5167387", "l": "Histiocytes | Nose | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Histiocytes | Nose | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5556517", "l": "atidarsagene autotemcel", "d": [], "t": []}, {"i": "NCIT:C180638", "l": "Atidarsagene Autotemcel", "d": [], "t": []}, {"i": "MESH:C000731759", "l": "", "d": [], "t": []}, {"i": "SNOMEDCT:1363393003", "l": "", "d": [], "t": []}], "preferred_name": "atidarsagene autotemcel", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5163451", "l": "Eosinophils | XXX | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Eosinophils | XXX | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C2924220", "l": "CD11c+CD103+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:1372962001", "l": "", "d": [], "t": []}], "preferred_name": "CD11c+CD103+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": 67.22985628720302, "identifiers": [{"i": "CL:0000835", "l": "myeloblast", "d": ["The most primitive precursor in the granulocytic series, having fine, evenly distributed chromatin, several nucleoli, a high nuclear-to-cytoplasmic ration (5:1-7:1), and a nongranular basophilic cytoplasm. They reside in the bone marrow."], "t": []}], "preferred_name": "myeloblast", "taxa": []}
{"type": "biolink:Cell", "ic": 83.11065783093733, "identifiers": [{"i": "UMLS:C1710150", "l": "Spindle A Melanoma Cell", "d": [], "t": []}, {"i": "NCIT:C54158", "l": "Spindle A Melanoma Cell", "d": [], "t": []}], "preferred_name": "Spindle A Melanoma Cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4722614", "l": "Theralux-ATIR", "d": [], "t": []}], "preferred_name": "Theralux-ATIR", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0002130", "l": "regular interatrial cardiac myocyte", "d": ["A cardiac myocyte of the interatrial region of the heart."], "t": []}, {"i": "UMLS:C2329620", "l": "Regular interatrial cardiac myocyte", "d": [], "t": []}], "preferred_name": "regular interatrial cardiac myocyte", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0333810", "l": "Knizocyte", "d": [], "t": []}, {"i": "SNOMEDCT:84082000", "l": "", "d": [], "t": []}], "preferred_name": "Knizocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1516096", "l": "B-Immunoblast", "d": [], "t": []}, {"i": "NCIT:C34033", "l": "B-Immunoblast", "d": ["A B-lymphocyte that has been transformed (activated) in response to antigenic stimulation."], "t": []}], "preferred_name": "B-Immunoblast", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1721044", "l": "Fetal Stem Cells", "d": [], "t": []}, {"i": "MESH:D053686", "l": "Fetal Stem Cells", "d": [], "t": []}], "preferred_name": "Fetal Stem Cells", "taxa": []}
{"type": "biolink:Cell", "ic": 92.76600187037766, "identifiers": [{"i": "CL:0002570", "l": "mesenchymal stem cell of adipose tissue", "d": ["A mesenchymal stem cell of adipose tissue."], "t": []}], "preferred_name": "mesenchymal stem cell of adipose tissue", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "CL:0002095", "l": "hilus cell of ovary", "d": ["A cell in the hilum of the ovary that produces androgens."], "t": []}, {"i": "UMLS:C0227897", "l": "Structure of hilar cell of ovary", "d": [], "t": []}, {"i": "SNOMEDCT:79891005", "l": "", "d": [], "t": []}], "preferred_name": "hilus cell of ovary", "taxa": []}
{"type": "biolink:Cell", "ic": 92.76600187037766, "identifiers": [{"i": "CL:4052010", "l": "pre-theca cell", "d": ["A stromal cell that serves as a precursor to the theca cell layers in the ovary growing follicles. This cell is present in the early stages of follicular growth, particularly in smaller follicles. Unlike mature theca cell, a pre-theca cell is initially non-steroidogenic and lacks luteinizing hormone receptors."], "t": []}], "preferred_name": "pre-theca cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4307085", "l": "CHOR NN_1 Slc17a8 choroid plexus epithelial cell (Mmus)", "d": ["A choroid plexus epithelial cell of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of 2900040C04Rik (Mmus), Slc17a8 (Mmus). It is distinguished from other CHOR NN cells by expression of Slc17a8. It is glutamatergic. These cells are located in the brain , in or close to the regions: choroid plexus, lateral ventricle . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5265 CHOR NN_1.", "A choroid plexus epithelial cell of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of 2900040C04Rik (Mmus), Slc17a8 (Mmus). It is distinguished from other CHOR NN cells by expression of Slc17a8. It is glutamatergic (inferred from expression of Slc17a8). These cells are located in the brain , in or close to the regions: choroid plexus, lateral ventricle . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5265 CHOR NN_1."], "t": []}], "preferred_name": "CHOR NN_1 Slc17a8 choroid plexus epithelial cell (Mmus)", "taxa": []}
{"type": "biolink:Cell", "ic": 82.16838616155795, "identifiers": [{"i": "CL:0005019", "l": "pancreatic epsilon cell", "d": ["Ghrelin secreting cells found in the endocrine pancreas."], "t": []}], "preferred_name": "pancreatic epsilon cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0000641", "l": "chromophobe cell", "d": ["A cell that is resistant to stains."], "t": []}], "preferred_name": "chromophobe cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C6021984", "l": "Leukocytes | Tissue and Smears | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Leukocytes | Tissue and Smears | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": 83.63771255585968, "identifiers": [{"i": "CL:0000506", "l": "enkephalin secreting cell", "d": ["An endorphine cell that secretes enkephalin."], "t": []}], "preferred_name": "enkephalin secreting cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4052058", "l": "Merkel cell of epidermis", "d": ["A Merkel cell found mainly in the basal layer of the epidermis and the outer root sheath of hair follicles, particularly concentrated in areas with high tactile acuity, such as touch domes, hair follicles, and fingertips."], "t": []}], "preferred_name": "Merkel cell of epidermis", "taxa": []}
{"type": "biolink:Cell", "ic": 86.30756602822301, "identifiers": [{"i": "CL:0002614", "l": "neuron of the substantia nigra", "d": ["A neuron of the substantia nigra."], "t": []}], "preferred_name": "neuron of the substantia nigra", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5216255", "l": "Lymphocytes|NCnc|Pt|Synv fld", "d": [], "t": []}], "preferred_name": "Lymphocytes|NCnc|Pt|Synv fld", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C2346935", "l": "Malignant Giant Osteoblast", "d": [], "t": []}, {"i": "NCIT:C67524", "l": "Malignant Giant Osteoblast", "d": [], "t": []}], "preferred_name": "Malignant Giant Osteoblast", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1267921", "l": "Lymphocyte positive for CD42A antigen", "d": [], "t": []}, {"i": "SNOMEDCT:117589001", "l": "", "d": [], "t": []}], "preferred_name": "Lymphocyte positive for CD42A antigen", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5157365", "l": "CD2 blasts | Blood | Cell markers", "d": [], "t": []}], "preferred_name": "CD2 blasts | Blood | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5216271", "l": "Monocytes.immature|NCnc|Pt|Bld", "d": [], "t": []}], "preferred_name": "Monocytes.immature|NCnc|Pt|Bld", "taxa": []}
{"type": "biolink:Cell", "ic": 78.54651317367835, "identifiers": [{"i": "CL:0000970", "l": "unswitched memory B cell", "d": ["An unswitched memory B cell is a memory B cell that has the phenotype IgM-positive, IgD-positive, CD27-positive, CD138-negative, IgG-negative, IgE-negative, and IgA-negative."], "t": []}], "preferred_name": "unswitched memory B cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0000993", "l": "mature CD11c-low plasmacytoid dendritic cell", "d": ["Mature CD11c-low plasmacytoid dendritic cell is a CD11c-low plasmacytoid dendritic cell that is CD83-high and is CD80-positive, CD86-positive, and MHCII-positive."], "t": []}], "preferred_name": "mature CD11c-low plasmacytoid dendritic cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0000551", "l": "unimodal nocireceptor", "d": [], "t": []}], "preferred_name": "unimodal nocireceptor", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5187172", "l": "Fibroblasts^Control", "d": [], "t": []}], "preferred_name": "Fibroblasts^Control", "taxa": []}
{"type": "biolink:Cell", "ic": 73.85694246010084, "identifiers": [{"i": "CL:2000028", "l": "cerebellum glutamatergic neuron", "d": ["Any glutamatergic neuron that is part of a cerebellum."], "t": []}], "preferred_name": "cerebellum glutamatergic neuron", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0002278", "l": "GIP cell", "d": ["An enteroendocrine cell of duodenum and jejunum that produces gastric inhibitory peptide."], "t": []}, {"i": "UMLS:C2335437", "l": "Type K enteroendocrine cell", "d": [], "t": []}], "preferred_name": "GIP cell", "taxa": []}
{"type": "biolink:Cell", "ic": 73.98236851641934, "identifiers": [{"i": "UMLS:C0333727", "l": "Signet ring cell", "d": [], "t": []}, {"i": "NCIT:C12487", "l": "Signet Ring Cell", "d": ["A neoplastic cell containing cytoplasmic mucin. The presence of mucin pushes the nucleus of the cell to the periphery, assuming a configuration resembling a signet ring."], "t": []}, {"i": "SNOMEDCT:86918008", "l": "", "d": [], "t": []}], "preferred_name": "Signet ring cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5216234", "l": "Leukocytes|NCnc|Pt|CSF", "d": [], "t": []}], "preferred_name": "Leukocytes|NCnc|Pt|CSF", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0002177", "l": "folliculostellate cell of pars distalis of adenohypophysis", "d": ["A supporting cell of the anterior pituitary gland involved in trophic and catabolic processes; expresses a broad spectrum of cytokeratins indicative of their epithelial nature."], "t": []}, {"i": "UMLS:C2332975", "l": "Folliculostellate cell of pars distalis of adenohypophysis", "d": [], "t": []}], "preferred_name": "folliculostellate cell of pars distalis of adenohypophysis", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4079034", "l": "thoracic dorsal root ganglion Piezo2 neuron", "d": ["A mechanosensitive sensory neuron whose soma is located in the thoracic dorsal root ganglion and that expresses the mechanically activated ion channel Piezo2 (encoded by PIEZO2). This neuron transduces mechanical stimuli and is involved in light touch perception and proprioception. In human DRG, Piezo2-immunoreactive neurons constitute approximately 35% of TrkA-positive neurons, compared to 26% in mouse (Rostock et al. 2018, PMID:29229553). This subpopulation includes both low-threshold mechanoreceptors mediating innocuous touch and a subset of mechanically sensitive nociceptors, reflecting the dual role of Piezo2 in somatosensation across species."], "t": []}], "preferred_name": "thoracic dorsal root ganglion Piezo2 neuron", "taxa": []}
{"type": "biolink:Cell", "ic": 90.871710685482, "identifiers": [{"i": "UMLS:C1517545", "l": "Giant Neoplastic Germ Cell", "d": [], "t": []}, {"i": "NCIT:C37134", "l": "Giant Neoplastic Germ Cell", "d": [], "t": []}], "preferred_name": "Giant Neoplastic Germ Cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5833280", "l": "CAR-T cell | Blood product unit | Blood bank", "d": [], "t": []}], "preferred_name": "CAR-T cell | Blood product unit | Blood bank", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0002456", "l": "CD8-alpha-positive plasmacytoid dendritic cell", "d": ["A CD11c-low plasmacytoid dendritic cell that is CD8-alpha-positive and CD4-positive."], "t": []}], "preferred_name": "CD8-alpha-positive plasmacytoid dendritic cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5157565", "l": "CD42 cells | Blood | Cell markers", "d": [], "t": []}], "preferred_name": "CD42 cells | Blood | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4042002", "l": "TAC3-positive medium spiny neuron", "d": ["A nucleus accumbens shell and olfactory tubercle D1 medium spiny neuron that co-expresses TAC3 and the DRD1 receptor."], "t": []}], "preferred_name": "TAC3-positive medium spiny neuron", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0003022", "l": "retinal ganglion cell C5", "d": ["A retinal ganglion cell C outer that has medium dendritic density and field size."], "t": []}], "preferred_name": "retinal ganglion cell C5", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0002134", "l": "stromal cell of ovarian medulla", "d": ["A stromal cell of the ovarian medulla."], "t": []}, {"i": "UMLS:C2336716", "l": "Stromal cell of ovarian medulla", "d": [], "t": []}], "preferred_name": "stromal cell of ovarian medulla", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1541584", "l": "Autologous Expanded Mesenchymal Stem Cells OTI-010", "d": [], "t": []}, {"i": "NCIT:C2534", "l": "Autologous Expanded Mesenchymal Stem Cells OTI-010", "d": ["Multipotent self-renewing adherent non-hematopoietic stromal cells harvested from a patient's bone marrow and grown in vitro. When injected back into the patient, autologous expanded mesenchymal stem cells OTI-010 may differentiate into various mesenchyme-derived cell types and, in some instances, may augment bone marrow engraftment after whole-body irradiation."], "t": []}], "preferred_name": "Autologous Expanded Mesenchymal Stem Cells OTI-010", "taxa": []}
{"type": "biolink:Cell", "ic": 48.880276295140646, "identifiers": [{"i": "CL:0007001", "l": "skeletogenic cell", "d": ["Cell that has the potential to form a skeletal cell type (e.g. cells in periosteum, cells in marrow) and produce extracellular matrix (often mineralized) and skeletal tissue (often mineralized)."], "t": []}], "preferred_name": "skeletogenic cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1267858", "l": "Lymphocyte positive for both CD8 antigen and CD57 antigen", "d": [], "t": []}, {"i": "SNOMEDCT:117541005", "l": "", "d": [], "t": []}], "preferred_name": "Lymphocyte positive for both CD8 antigen and CD57 antigen", "taxa": []}
{"type": "biolink:Cell", "ic": 81.34422831136257, "identifiers": [{"i": "CL:1001428", "l": "bladder urothelial cell", "d": ["A urothelial cell that is part of the urothelium of the urinary bladder."], "t": []}], "preferred_name": "bladder urothelial cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C2346881", "l": "Autologous Ad-CD154-Transduced CLL B Cells", "d": [], "t": []}, {"i": "NCIT:C68842", "l": "Autologous Ad-CD154-Transduced CLL B Cells", "d": ["An autologous tumor cell vaccine containing chronic lymphocytic leukemia (CLL) B cells transduced with an adenoviral vector carrying chimeric CD154 (ad-CD154) with potential antineoplastic activity. Administration of autologous ad-CD154 transduced CLL B cells may result in increases in the numbers of leukemia-specific CD4+ T cells and high serum-levels of IL-12 and IFN-gamma. Due to ligation of CD154 to CD40 on CLL cells, this agent may induce CLL cells to express the proapoptotic molecule BID and death receptors CD95 (Fas) and DR5, rendering CLL B cells first resistant and then sensitive to Fas-mediated apoptosis. In addition, autologous ad-CD154 transduced CLL B cells may induce MHC class I-dependent cytotoxic T lymphocyte (CTL) responses against autologous leukemia cells. CD154 is a type II membrane glycoprotein and ligand for CD40; both molecules are important in cognate co-stimulatory cell-cell interactions."], "t": []}], "preferred_name": "Autologous Ad-CD154-Transduced CLL B Cells", "taxa": []}
{"type": "biolink:Cell", "ic": 85.53200374075534, "identifiers": [{"i": "UMLS:C1510729", "l": "Abnormal Large Granular Lymphocyte", "d": [], "t": []}, {"i": "NCIT:C40983", "l": "Abnormal Large Granular Lymphocyte", "d": [], "t": []}], "preferred_name": "Abnormal Large Granular Lymphocyte", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C6022670", "l": "Allogeneic MultiTAA-specific T-lymphocytes MT-401", "d": [], "t": []}], "preferred_name": "Allogeneic MultiTAA-specific T-lymphocytes MT-401", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C3897770", "l": "Reactive Amniocyte", "d": [], "t": []}, {"i": "NCIT:C118138", "l": "Reactive Amniocyte", "d": ["Proliferation and aggregation of amniocytes due to a meconium exposure."], "t": []}], "preferred_name": "Reactive Amniocyte", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1267977", "l": "Lymphocyte positive for CD87 antigen", "d": [], "t": []}, {"i": "SNOMEDCT:117417005", "l": "", "d": [], "t": []}], "preferred_name": "Lymphocyte positive for CD87 antigen", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5216247", "l": "Lymphocytes.variant|NCnc|Pt|Bld", "d": [], "t": []}], "preferred_name": "Lymphocytes.variant|NCnc|Pt|Bld", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0003016", "l": "G11-OFF retinal ganglion cell", "d": ["A G11 retinal ganglion cell that has post synaptic terminals in sublaminar layer S2 and is depolarized by decreased illumination of their receptive field center"], "t": []}], "preferred_name": "G11-OFF retinal ganglion cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4072034", "l": "lamp5 GABAergic interneuron (Homo sapiens)", "d": ["A transcriptomically distinct GABAergic neuron located in the cerebral cortex that expresses Lamp5. The standard transcriptomic reference data for this cell type can be found on the CellxGene census under the collection: 'Transcriptomic cytoarchitecture reveals principles of human neocortex organization', dataset: 'Supercluster: CGE-derived interneurons', Author Categories: 'CrossArea_subclass', clusters Lamp5."], "t": []}], "preferred_name": "lamp5 GABAergic interneuron (Homo sapiens)", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "UMLS:C1513979", "l": "Neoplastic Glomerulosa Cell", "d": [], "t": []}, {"i": "NCIT:C36927", "l": "Neoplastic Glomerulosa Cell", "d": [], "t": []}], "preferred_name": "Neoplastic Glomerulosa Cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4246710", "l": "Vascular smooth muscle cell of coronary artery", "d": [], "t": []}], "preferred_name": "Vascular smooth muscle cell of coronary artery", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0242598", "l": "LLC-PK1 Cells", "d": [], "t": []}, {"i": "MESH:D018374", "l": "LLC-PK1 Cells", "d": [], "t": []}], "preferred_name": "LLC-PK1 Cells", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1979642", "l": "Blast cell positive for CD25 antigen", "d": [], "t": []}, {"i": "SNOMEDCT:724263000", "l": "", "d": [], "t": []}], "preferred_name": "Blast cell positive for CD25 antigen", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1183167", "l": "Set of aminergic cells", "d": [], "t": []}], "preferred_name": "Set of aminergic cells", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4033113", "l": "cervicothoracic ganglion enkephalin neuron", "d": ["A sympathetic neuron that has the soma located in the cervicothoracic ganglion and expresses the marker enkephalin."], "t": []}], "preferred_name": "cervicothoracic ganglion enkephalin neuron", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1440245", "l": "CD11a+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:1372826003", "l": "", "d": [], "t": []}], "preferred_name": "CD11a+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C2338967", "l": "Interleukin 12-activated natural killer cell", "d": [], "t": []}], "preferred_name": "Interleukin 12-activated natural killer cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5963193", "l": "Autologous CRISPR-Cas9 Engineered Regnase-1/SOCS1 Dual-edited Tumor Infiltrating Lymphocytes KSQ-004EX", "d": [], "t": []}], "preferred_name": "Autologous CRISPR-Cas9 Engineered Regnase-1/SOCS1 Dual-edited Tumor Infiltrating Lymphocytes KSQ-004EX", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C2350248", "l": "Hemangioblasts", "d": [], "t": []}, {"i": "MESH:D055018", "l": "Hemangioblasts", "d": [], "t": []}], "preferred_name": "Hemangioblasts", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0545587", "l": "Blood large lymphocyte", "d": [], "t": []}], "preferred_name": "Blood large lymphocyte", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1268005", "l": "Hematopoietic precursor cell", "d": [], "t": []}, {"i": "SNOMEDCT:127911004", "l": "", "d": [], "t": []}], "preferred_name": "Hematopoietic precursor cell", "taxa": []}
{"type": "biolink:Cell", "ic": 92.76600187037766, "identifiers": [{"i": "CL:0008011", "l": "skeletal muscle satellite stem cell", "d": ["A skeletal muscle satellite cell that divides by stem cell division.  A proportion of this population undergoes symmetric stem cell division, producing two skeletal muscle satellite stem cells. The rest undergo asymmetric stem cell division - retaining their identity while budding off a daughter cell that differentiates into an adult skeletal muscle myoblast."], "t": []}], "preferred_name": "skeletal muscle satellite stem cell", "taxa": []}
{"type": "biolink:Cell", "ic": 92.76600187037766, "identifiers": [{"i": "CL:4301583", "l": "CBX Purkinje Gaba_2 Purkinje cell (Mmus)", "d": ["A Purkinje cell of the Mus musculus brain. Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Supertype:1153 CBX Purkinje Gaba_2."], "t": []}], "preferred_name": "CBX Purkinje Gaba_2 Purkinje cell (Mmus)", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5784049", "l": "Autologous ALPG/ALPP-targeted Anti-MSLN CAR-Fas/PTPN2 shRNA-miR-expressing T-lymphocytes AB-1015", "d": [], "t": []}, {"i": "NCIT:C190955", "l": "Autologous ALPG/ALPP-targeted Anti-MSLN CAR-Fas/PTPN2 shRNA-miR-expressing T-lymphocytes AB-1015", "d": ["A preparation of autologous T-lymphocytes that have been modified to encode a genetic circuit consisting of a priming receptor that induces the expression of a chimeric antigen receptor (CAR) specific for the tumor-associated antigen (TAA) mesothelin (MSLN) upon binding to the TAAs alkaline phosphatase (ALP) isozymes ALP germ cell type (ALPG; GCAP) or ALP placental type (ALPP; placental ALP; PLAP), and a dual microRNA-adapted short hairpin RNA (shRNA-miR) targeting Fas (FAS; CD95; APO-1; tumor necrosis factor receptor superfamily member 6; TNFRSF6) and tyrosine-protein phosphatase non-receptor type 2 (PTPN2), with potential immunomodulating and antineoplastic activities. Upon administration, the autologous ALPG/P-targeted anti-MSLN CAR-Fas/PTPN2 shRNA-miR-expressing T-lymphocytes AB-1015 target and bind to ALPG/P-expressing tumor cells and induce the expression of anti-MSLN CAR, thereby killing ALPG/P- and MSLN-expressing tumor cells. The downregulation of the expression of Fas by the shRNA-miR prevents Fas-mediated apoptosis of the AB-1015 T-cells in the tumor microenvironment (TME). The downregulation of the expression of PTPN2 enhances AB-1015 T-cell expansion and anti-tumor T-cell immune responses. ALPG and ALPP, overexpressed in a variety of cancer cell types, play important roles in tumor cell proliferation and tumor growth. MSLN, a cell surface glycoprotein involved in cell adhesion, is overexpressed in a variety of cancer cell types."], "t": []}], "preferred_name": "Autologous ALPG/ALPP-targeted Anti-MSLN CAR-Fas/PTPN2 shRNA-miR-expressing T-lymphocytes AB-1015", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4322816", "l": "CD79A+ B lymphocyte", "d": [], "t": []}], "preferred_name": "CD79A+ B lymphocyte", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1317185", "l": "CD10+CD20+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:1372956006", "l": "", "d": [], "t": []}], "preferred_name": "CD10+CD20+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C2985194", "l": "E. coli CD-expressing Genetically Modified Neural Stem Cells", "d": [], "t": []}, {"i": "NCIT:C92585", "l": "E. coli CD-expressing Genetically Modified Neural Stem Cells", "d": ["Genetically-modified neural stem cells (NSCs) transfected with the Escherichia coli (E. coli) suicidal gene cytosine deaminase (CD), with potential antineoplastic adjuvant activity. Upon intracerebral injection, E. coli CD-expressing genetically modified NSCs express the E. coli cytosine deaminase, an enzyme that catalyzes the intracellular conversion of the nontoxic prodrug 5-fluorocytosine (5-FC) into the cytotoxic 5-fluorouracil (5-FU). Co-administration of this agent with 5-FC and upon local activation of 5-FU in the brain tumor, 5-FU disrupts DNA synthesis in tumor cells thereby impeding cellular proliferation with minimal systemic exposure and toxicity."], "t": []}], "preferred_name": "E. coli CD-expressing Genetically Modified Neural Stem Cells", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5446933", "l": "NKX101", "d": [], "t": []}, {"i": "NCIT:C176027", "l": "Allogeneic NKG2D-OX40-CD3zeta-CAR-mbIL-15-expressing Natural Killer Cells NKX101", "d": ["A preparation of off-the-shelf (OTS), allogeneic and ex vivo expanded natural killer cells (NKs) that are engineered to express membrane-bound IL-15 (mbIL15) and a chimeric antigen receptor (CAR) encoding for human natural-killer group 2, member D receptor protein (NKG2D; KLRK1; natural killer cell activating receptor group 2D) that is coupled to the co-stimulatory domain of OX40 (CD134), and to the zeta chain of the TCR/CD3 complex (CD3-zeta; CD3zeta), with potential immunomodulating and antineoplastic activities. Upon transfusion of the allogeneic NKG2D-OX40-CD3zeta-CAR-mbIL-15-expressing NKs NKX101, these cells specifically target and bind to tumor cells expressing NKG2D ligands (NKG2DL). This induces secretion of pro-inflammatory cytokines and results in the lysis of NKG2DL-expressing tumor cells. In addition, these cells target, bind to and kill NKG2DL-expressing tumor-associated endothelial cells in the neovasculature and immunosuppressive cells, such as regulatory T-cells (Tregs) and myeloid-derived suppressor cells (MDSCs) in the tumor microenvironment (TME) that express NKG2D ligands. IL-15 is a pro-survival cytokine that potentiates the immune response against tumor cells. NKG2D ligands are overexpressed in a variety of cancer cells."], "t": []}], "preferred_name": "NKX101", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0009034", "l": "dendritic cell of appendix", "d": ["A dendritic cell that is located in a vermiform appendix."], "t": []}], "preferred_name": "dendritic cell of appendix", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4052046", "l": "early luteal cell", "d": ["A luteal cell that is part of the young, developing corpus luteum. This cell promotes progesterone synthesis, marked by high Parm1 expression in mice (Lan et al., 2024). An early luteal cell is associated with steroidogenesis and cell growth, contributing to early corpus luteum function and maturation."], "t": []}], "preferred_name": "early luteal cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5157506", "l": "CD36 blasts | XXX | Cell markers", "d": [], "t": []}], "preferred_name": "CD36 blasts | XXX | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C2337780", "l": "Dendritic reticular cell", "d": [], "t": []}], "preferred_name": "Dendritic reticular cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1276853", "l": "Entire parathyroid oxyphil cell", "d": [], "t": []}, {"i": "SNOMEDCT:177826000", "l": "", "d": [], "t": []}], "preferred_name": "Entire parathyroid oxyphil cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4307064", "l": "Tanycyte NN_1 Glp1r tanycyte (Mmus)", "d": ["A tanycyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of C230072F16Rik (Mmus), Glp1r (Mmus). It is distinguished from other Tanycyte NN_1 cells by expression of Glp1r. These cells are located in the Hypothalamus, brain , in or close to the regions: Anteroventral periventricular nucleus . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5244 Tanycyte NN_1."], "t": []}], "preferred_name": "Tanycyte NN_1 Glp1r tanycyte (Mmus)", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5401602", "l": "Virus Specific T-Cell", "d": [], "t": []}], "preferred_name": "Virus Specific T-Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 74.11023018174025, "identifiers": [{"i": "UMLS:C1516090", "l": "Atypical Chondrocyte", "d": [], "t": []}, {"i": "NCIT:C36984", "l": "Atypical Chondrocyte", "d": [], "t": []}], "preferred_name": "Atypical Chondrocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C3274553", "l": "Tri-virus/GD2-specific Allogeneic Cytotoxic T-lymphocytes", "d": [], "t": []}, {"i": "NCIT:C99132", "l": "Tri-virus/GD2-specific Allogeneic Cytotoxic T-lymphocytes", "d": ["Allogeneic tri-viral specific, Epstein-Barr virus (EBV), cytomegalovirus (CMV) and adenovirus (Ad), cytotoxic T-lymphocytes (tV-CTLs) expressing a chimeric antigen receptor (CAR) specific for disialoganglioside GD2 with potential antineoplastic activity. Tri-virus/GD2-specific allogeneic CTLs are produced by transducing tV-CTLs with a GD2-specific CAR retroviral vector. Upon administration, after an allogeneic hematopoietic stem cell transplant, these CTLs may be selective towards EBV, CMV, and Ad-infected cells and GD2-expressing tumor cells. The human glycosphingolipid GD2 is a tumor associated antigen overexpressed on the surface of all tumors of neuroectodermal origin."], "t": []}], "preferred_name": "Tri-virus/GD2-specific Allogeneic Cytotoxic T-lymphocytes", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C4289582", "l": "EpCAM-specific CAR-expressing Autologous T-lymphocytes", "d": [], "t": []}, {"i": "NCIT:C126801", "l": "EpCAM-specific CAR-expressing Autologous T-lymphocytes", "d": ["A preparation of autologous T-lymphocytes that have been genetically modified to express a chimeric antigen receptor (CAR) specific for the antigen epithelial cell adhesion molecule (EpCAM), with potential immunostimulating and antineoplastic activities. Upon administration, the EpCAM-specific CAR-expressing autologous T-lymphocytes specifically recognize and bind to EpCAM-expressing tumor cells, resulting in tumor cell lysis. EpCAM, a cell surface protein, is expressed by a variety of tumor cells."], "t": []}], "preferred_name": "EpCAM-specific CAR-expressing Autologous T-lymphocytes", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C3179111", "l": "Feeder Layer Cells", "d": [], "t": []}], "preferred_name": "Feeder Layer Cells", "taxa": []}
{"type": "biolink:Cell", "ic": 79.35380886648232, "identifiers": [{"i": "UMLS:C1709189", "l": "Neoplastic Parathyroid Gland Cell", "d": [], "t": []}, {"i": "NCIT:C48265", "l": "Neoplastic Parathyroid Gland Cell", "d": [], "t": []}], "preferred_name": "Neoplastic Parathyroid Gland Cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5690732", "l": "MDA-MB-231 Cells", "d": [], "t": []}, {"i": "MESH:D000092302", "l": "MDA-MB-231 Cells", "d": [], "t": []}], "preferred_name": "MDA-MB-231 Cells", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5173467", "l": "Monocytes+Macrophages | Body fluid | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Monocytes+Macrophages | Body fluid | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": 90.871710685482, "identifiers": [{"i": "CL:0000382", "l": "scolopale cell", "d": ["A cell that is part of a scolopidium and surrounds the dendrite of a scolopidial neuron."], "t": []}], "preferred_name": "scolopale cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1440406", "l": "Cells.t(14;18)(q32;q21.3)(IGH,BCL2)", "d": [], "t": []}], "preferred_name": "Cells.t(14;18)(q32;q21.3)(IGH,BCL2)", "taxa": []}
{"type": "biolink:Cell", "ic": 77.82747199602274, "identifiers": [{"i": "UMLS:C1518984", "l": "Neoplastic Perineurial-Like Cell", "d": [], "t": []}, {"i": "NCIT:C37152", "l": "Neoplastic Perineurial-Like Cell", "d": [], "t": []}], "preferred_name": "Neoplastic Perineurial-Like Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4033004", "l": "smooth muscle cell of taenia coli", "d": ["A(n) smooth muscle cell that is part of a(n) taenia coli."], "t": []}], "preferred_name": "smooth muscle cell of taenia coli", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C0333853", "l": "Cleaved cell", "d": [], "t": []}, {"i": "NCIT:C28128", "l": "Cleaved Cell", "d": [], "t": []}, {"i": "SNOMEDCT:58604003", "l": "", "d": [], "t": []}], "preferred_name": "Cleaved cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:1001597", "l": "seminal vesicle glandular cell", "d": ["Glandular cell of seminal vesicle epithelium."], "t": []}], "preferred_name": "seminal vesicle glandular cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0002509", "l": "CD103-positive, langerin-positive lymph node dendritic cell", "d": ["A langerin-positive lymph node dendritic cell that is CD103-positive and CD11b-low."], "t": []}], "preferred_name": "CD103-positive, langerin-positive lymph node dendritic cell", "taxa": []}
{"type": "biolink:Cell", "ic": 41.25867304969097, "identifiers": [{"i": "UMLS:C1518174", "l": "Malignant Epithelial Cell", "d": [], "t": []}, {"i": "NCIT:C36779", "l": "Malignant Epithelial Cell", "d": [], "t": []}], "preferred_name": "Malignant Epithelial Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 84.21065366064373, "identifiers": [{"i": "CL:0002046", "l": "early pro-B cell", "d": ["A pro-B cell that is CD22-positive, CD34-positive, CD38-positive and TdT-positive (has TdT activity). Pre-BCR is expressed on the cell surface. Cell is CD19-negative, CD20-negative, complement receptor type 2-negative and CD10-low. D-to-J recombination of the heavy chain occurs at this stage."], "t": []}], "preferred_name": "early pro-B cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5163446", "l": "Eosinophils | Stool | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Eosinophils | Stool | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C4085937", "l": "Adipose-derived Stromal Vascular Fraction Cells", "d": [], "t": []}, {"i": "NCIT:C124992", "l": "Adipose-derived Stromal Vascular Fraction Cells", "d": ["A population of stromal vascular fraction (SVF) cells derived from autologous adipose tissue, with potential tissue regenerative activity. SVF cells are obtained through liposuction and contain multiple cell types, including adipose-derived stem cells (ADSCs), mesenchymal and endothelial progenitor cells, leukocyte subtypes, lymphatic cells, pericytes, and vascular smooth muscle cells. The SVF cells are processed in such a way as to contain a reproducible and consistent composition of heterogeneous cells. Upon processing and administration, the adipose-derived SVF cells can differentiate into different tissue types, support neovascularization, replace cells and repair injured issue."], "t": []}], "preferred_name": "Adipose-derived Stromal Vascular Fraction Cells", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5174614", "l": "Neutrophils | Body fluid | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Neutrophils | Body fluid | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4033047", "l": "OFF midget ganglion cell", "d": ["A midget ganglion cell that depolarizes in response to decreased light intensity in the center of its receptive field. The majority of input that this cell receives comes from flat midget bipolar cells."], "t": []}], "preferred_name": "OFF midget ganglion cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4079008", "l": "cervical dorsal root ganglion TRPV1 neuron", "d": ["A polymodal nociceptor whose soma is located in the cervical dorsal root ganglion and that expresses the transient receptor potential vanilloid 1 channel (TRPV1, encoded by TRPV1). This neuron detects noxious heat above 43 degrees Celsius, protons, and endogenous lipid mediators, and is activated by capsaicin. In human DRG, TRPV1-immunoreactive neurons constitute approximately 54% of TrkA-positive neurons, significantly higher than the 35% observed in mouse (Rostock et al. 2018, PMID:29229553). These neurons are predominantly small-diameter nociceptors that innervate skin and visceral organs, where they function as primary detectors of thermal and chemical noxious stimuli."], "t": []}], "preferred_name": "cervical dorsal root ganglion TRPV1 neuron", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1440369", "l": "CD93+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:1372943004", "l": "", "d": [], "t": []}], "preferred_name": "CD93+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0002426", "l": "CD11b-positive, CD27-positive natural killer cell, mouse", "d": ["A mature natural killer cell that is CD11b-positive and CD27-positive."], "t": []}], "preferred_name": "CD11b-positive, CD27-positive natural killer cell, mouse", "taxa": []}
{"type": "biolink:Cell", "ic": 84.21065366064373, "identifiers": [{"i": "UMLS:C1519174", "l": "Salivary Gland Myoepithelial Cell", "d": [], "t": []}, {"i": "NCIT:C40411", "l": "Salivary Gland Myoepithelial Cell", "d": [], "t": []}], "preferred_name": "Salivary Gland Myoepithelial Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1518114", "l": "MB02 cell line", "d": [], "t": []}, {"i": "NCIT:C20276", "l": "MB02", "d": ["Provider: Maria Biotech Co. Ltd. - Maria Infertility Hospital Medical Institute, Seoul, Korea. Information from provider and not independently verified by NIH: Cells are positive for cell markers SSEA-3, SSEA-4, Oct-4, alkaline phosphatase activity and telomerase activity; Cells are negative for the cell marker SSEA-1; Cell has normal karyotype (46 XX); Differentiation in vitro into neuron; Cells were cultured in feeder-free culture condition using Matrigel coated plate. This cell line meets the criteria for the use of human embryonic stem cells by federally funded researchers."], "t": []}], "preferred_name": "MB02 cell line", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5216194", "l": "Basophils|NCnc|Pt|Synv fld", "d": [], "t": []}], "preferred_name": "Basophils|NCnc|Pt|Synv fld", "taxa": []}
{"type": "biolink:Cell", "ic": 92.76600187037766, "identifiers": [{"i": "CL:0000726", "l": "chlamydospore", "d": ["An asexual 1-celled spore (primarily for perennation, not dissemination). Originates endogenously and singly within part of a pre-existing cell by the contraction of the protoplast. Possesses an inner secondary and often thickened hyaline or brown wall, usually impregnated with hydrophobic material."], "t": []}], "preferred_name": "chlamydospore", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C4726562", "l": "Anti-CD19/CD20/CD22/CD30 CAR-T Cells", "d": [], "t": []}, {"i": "NCIT:C151935", "l": "Anti-CD19/CD20/CD22/CD30 CAR-T Cells", "d": ["A preparation of human T-lymphocytes engineered to express a chimeric antigen receptor (CAR) specific for the tumor-associated antigens (TAAs) cluster of differentiation 19 (CD19), CD20, CD22 and CD30, with potential immunostimulating and antineoplastic activities. Upon administration, the anti-CD19/CD20/CD22/CD30 CAR-T cells target and bind to CD19, CD20, CD22 and CD30 expressed on the surface of certain tumor cells. This induces selective toxicity in tumor cells expressing these TAAs. The TAAs are overexpressed in certain hematologic malignancies."], "t": []}], "preferred_name": "Anti-CD19/CD20/CD22/CD30 CAR-T Cells", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1708924", "l": "Malignant Transitional Cell with Large Nucleus and Small Nucleolus", "d": [], "t": []}, {"i": "NCIT:C54554", "l": "Malignant Transitional Cell with Large Nucleus and Small Nucleolus", "d": [], "t": []}], "preferred_name": "Malignant Transitional Cell with Large Nucleus and Small Nucleolus", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4030018", "l": "kidney connecting tubule principal cell", "d": ["A renal principal cell located in the connecting tubule."], "t": []}], "preferred_name": "kidney connecting tubule principal cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C4055481", "l": "Akt-1/2 Inhibitor-treated Tumor Infiltrating Lymphocytes", "d": [], "t": []}, {"i": "NCIT:C123720", "l": "Akt-1/2 Inhibitor-treated Tumor Infiltrating Lymphocytes", "d": ["Autologous tumor infiltrating lymphocytes (TILs) harvested directly from the infiltrate of a patient's tumor and treated with an inhibitor of the serine/threonine kinases Akt-1 and -2 (Akti-1/2) during ex vivo expansion, with potential antineoplastic activity. Upon reintroduction into the patient, the Akti-1/2-treated TILs recognize and kill cancer cells. Akt inhibition promotes the immunologic memory of the TILs and enhances their expansion, in vivo long-term persistence and antitumor activity."], "t": []}], "preferred_name": "Akt-1/2 Inhibitor-treated Tumor Infiltrating Lymphocytes", "taxa": []}
{"type": "biolink:Cell", "ic": 92.76600187037766, "identifiers": [{"i": "UMLS:C1882055", "l": "Neoplastic Large Polygonal Sertoli Cell", "d": [], "t": []}, {"i": "NCIT:C61417", "l": "Neoplastic Large Polygonal Sertoli Cell", "d": [], "t": []}], "preferred_name": "Neoplastic Large Polygonal Sertoli Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 65.69725873753356, "identifiers": [{"i": "UMLS:C1709184", "l": "Neoplastic Lipocyte", "d": [], "t": []}, {"i": "NCIT:C48683", "l": "Neoplastic Lipocyte", "d": [], "t": []}], "preferred_name": "Neoplastic Lipocyte", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1292098", "l": "IgD B lymphocyte", "d": [], "t": []}, {"i": "SNOMEDCT:115604004", "l": "", "d": [], "t": []}], "preferred_name": "IgD B lymphocyte", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1440409", "l": "Cells.t(2;5)(p23;q35.1)(ALK,NPM1)", "d": [], "t": []}], "preferred_name": "Cells.t(2;5)(p23;q35.1)(ALK,NPM1)", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:7770006", "l": "beam B cell, human", "d": ["A trabecular meshwork cell within the eye's trabecular meshwork. This cell is molecularly distinguished by TMEFF2 expression in humans. A beam B cell is spatially intermingled with beam A cells throughout the uveal and corneoscleral meshwork regions, but demonstrates a tendency to localise closer to the juxtacanalicular tissue."], "t": []}], "preferred_name": "beam B cell, human", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4322671", "l": "CD14+ myeloid cell", "d": [], "t": []}], "preferred_name": "CD14+ myeloid cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5216189", "l": "Basophils.immature|NCnc|Pt|Bld", "d": [], "t": []}], "preferred_name": "Basophils.immature|NCnc|Pt|Bld", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5670749", "l": "MC-38", "d": [], "t": []}, {"i": "NCIT:C186782", "l": "MC-38", "d": ["A cell line derived from C57BL/6 murine colon adenocarcinoma cells. The cells are adherent and have a fibroblast morphology. MC38 cells will form tumors and metastases post-implantation into syngeneic C57BL/6 mice or immunocompromised mice."], "t": []}], "preferred_name": "MC-38", "taxa": []}
{"type": "biolink:Cell", "ic": 31.503757264834004, "identifiers": [{"i": "CL:0000404", "l": "electrically signaling cell", "d": ["A cell that initiates an electrical signal and passes that signal to another cell."], "t": []}], "preferred_name": "electrically signaling cell", "taxa": []}
{"type": "biolink:Cell", "ic": 92.76600187037766, "identifiers": [{"i": "CL:0000141", "l": "cementocyte", "d": ["An osteocytelike cell with numerous processes, trapped in a lacuna in the cement of the tooth."], "t": []}, {"i": "UMLS:C1179503", "l": "Cementocyte", "d": [], "t": []}, {"i": "NCIT:C32275", "l": "Cementocyte", "d": ["A cell in a hollow cavity of cellular cementum, ranging in shape from round to oval or flattened, and exhibiting numerous protoplasmic processes extending from its free surface."], "t": []}], "preferred_name": "cementocyte", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5222947", "l": "CD3- CD16+ cells/100 cells in tissue", "d": [], "t": []}], "preferred_name": "CD3- CD16+ cells/100 cells in tissue", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5708028", "l": "Voxeralgagene Autotemcel", "d": [], "t": []}], "preferred_name": "Voxeralgagene Autotemcel", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5157360", "l": "CD19+Kappa+ cells | Blood | Cell markers", "d": [], "t": []}], "preferred_name": "CD19+Kappa+ cells | Blood | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4307069", "l": "beta1-tancyte (Mmus)", "d": ["A beta1-tanycyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Gpr50 (Mmus), Frzb (Mmus), Foxd2os (Mmus). It is distinguished from other Tanycyte NN_2 cells by expression of Col25a1, C230072F16Rik. These cells are located in the Hypothalamus, brain , in or close to the regions: third ventricle, Arcuate hypothalamic nucleus . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5249 Tanycyte NN_2."], "t": []}], "preferred_name": "beta1-tancyte (Mmus)", "taxa": []}
{"type": "biolink:Cell", "ic": 89.40238429118027, "identifiers": [{"i": "UMLS:C1513957", "l": "Neoplastic Eosinophilic Cell Oncocyte", "d": [], "t": []}, {"i": "NCIT:C37166", "l": "Neoplastic Eosinophilic Cell Oncocyte", "d": [], "t": []}], "preferred_name": "Neoplastic Eosinophilic Cell Oncocyte", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5978247", "l": "Granulocytes|NCnc|Pt|Dial fld prt", "d": [], "t": []}], "preferred_name": "Granulocytes|NCnc|Pt|Dial fld prt", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5785347", "l": "Autologous Anti-LILRB4 CAR-T Cells", "d": [], "t": []}, {"i": "NCIT:C192644", "l": "Autologous Anti-LILRB4 CAR-T Cells", "d": ["A preparation of autologous T-lymphocytes that have been genetically modified and transduced with a lentiviral vector expressing a T-cell-receptor (TCR) complex-based chimeric antigen receptor (CAR) specific for two different epitopes of the immune inhibitory receptor leukocyte immunoglobulin-like receptor B member 4 (LILRB4; ILT3; ILT-3), with potential immune checkpoint inhibitory and antineoplastic activities. Upon administration, autologous anti-LILRB4 CAR-T cells target and bind to two different epitopes of LILRB4 expressed on tumor cells. This results in a cytotoxic T-lymphocyte (CTL) response against LILRB4-expressing tumor cells. LILRB4, a tumor associated antigen (TAA) and an immune inhibitory receptor expressed on immune suppressive myeloid cells, is highly expressed on certain hematologic cancer cells, such as monocytic acute myeloid leukemia (AML) cells. It functions as an immune checkpoint that negatively regulates T-cell activation as its extracellular domain inhibits T-cell activity. It plays an important role in tumor infiltration, T-cell suppression and immune tolerance."], "t": []}], "preferred_name": "Autologous Anti-LILRB4 CAR-T Cells", "taxa": []}
{"type": "biolink:Cell", "ic": 92.76600187037766, "identifiers": [{"i": "CL:0002574", "l": "stromal cell of pancreas", "d": ["A stromal cell of the pancreas."], "t": []}], "preferred_name": "stromal cell of pancreas", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C4684970", "l": "Anti-CD19-CD20-CAR-CD3zeta-4-1BB-expressing Autologous T-lymphocytes", "d": [], "t": []}, {"i": "NCIT:C143156", "l": "Anti-CD19-CD20-CAR-CD3zeta-4-1BB-expressing Autologous T-lymphocytes", "d": ["Autologous T-lymphocytes that have been transduced with a lentiviral vector to express a chimeric antigen receptor (CAR) consisting of a single chain variable fragment (scFv) of anti-CD19 in tandem with an anti-CD20 scFv, and coupled to the cytoplasmic portion of the zeta chain of the human T-cell receptor (CD3zeta), and the co-stimulatory molecule 4-1BB (CD137), with potential immunostimulating and antineoplastic activities. Upon transfusion, anti-CD19-CD20-CAR-CD3zeta-4-1BB-expressing autologous T-lymphocytes recognize and direct T-cells to CD19- or CD20-expressing tumor B-cells. This results in a cytotoxic T-lymphocyte (CTL) response against CD19- or CD20-expressing tumor cells, and causes tumor cell lysis. Both CD19 and CD20 are B-cell-specific cell surface antigens overexpressed in B-cell lineage malignancies."], "t": []}], "preferred_name": "Anti-CD19-CD20-CAR-CD3zeta-4-1BB-expressing Autologous T-lymphocytes", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1440318", "l": "CD46+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:1372894007", "l": "", "d": [], "t": []}], "preferred_name": "CD46+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": 90.871710685482, "identifiers": [{"i": "CL:0000952", "l": "preBCR-positive large pre-B-II cell", "d": ["An preBRC-positive large pre-B-II cell is a large pre-B-II cell that is pre-B cell receptor-positive, composed of surrogate light chain protein (SL), which is composed of VpreB , Lambda 5/14.1, in complex with immunoglobulin mu heavy chain (IgHmu) on the cell surface."], "t": []}], "preferred_name": "preBCR-positive large pre-B-II cell", "taxa": []}
{"type": "biolink:Cell", "ic": 87.18682603146104, "identifiers": [{"i": "CL:1001021", "l": "kidney loop of Henle descending limb epithelial cell", "d": ["Any kidney loop of Henle epithelial cell that is part of some descending limb of loop of Henle."], "t": []}], "preferred_name": "kidney loop of Henle descending limb epithelial cell", "taxa": []}
{"type": "biolink:Cell", "ic": 88.20185721311867, "identifiers": [{"i": "UMLS:C1510955", "l": "Malignant Glomus Cell", "d": [], "t": []}, {"i": "NCIT:C36966", "l": "Malignant Glomus Cell", "d": [], "t": []}], "preferred_name": "Malignant Glomus Cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5163438", "l": "Eosinophils | Cerebral spinal fluid | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Eosinophils | Cerebral spinal fluid | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C4687585", "l": "Autologous PBLs Retrovirally-transduced with TCRs Targeting Neoantigens", "d": [], "t": []}, {"i": "NCIT:C146937", "l": "Autologous PBLs Retrovirally-transduced with TCRs Targeting Neoantigens", "d": ["Autologous human peripheral blood lymphocytes (PBLs) transduced with a retroviral vector encoding T-cell receptors (TCRs) specific for a patient's individual and unique mutated antigens, with potential immunostimulating and antineoplastic activities. Tumor cells are analyzed to identify and isolate specific mutated tumor-associated antigens (TAAs) that are expressed by the patient's tumor cells; then T-cell receptor coding sequences are engineered to target the patient's TAAs and inserted into retroviral vectors. After transduction, expansion in culture, and reintroduction into the patient, neoantigen-specific TCRs retroviral vector-transduced autologous PBLs recognize and bind to tumor cells expressing the patient's neoantigens, which results in a specific cytotoxic T-lymphocyte (CTL)-mediated immune response against the patient's tumor cells."], "t": []}], "preferred_name": "Autologous PBLs Retrovirally-transduced with TCRs Targeting Neoantigens", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5783438", "l": "Anbalcabtagene Autoleucel", "d": [], "t": []}], "preferred_name": "Anbalcabtagene Autoleucel", "taxa": []}
{"type": "biolink:Cell", "ic": 86.30756602822301, "identifiers": [{"i": "UMLS:C0333633", "l": "Hemosiderin-laden macrophage", "d": [], "t": []}, {"i": "NCIT:C36847", "l": "Hemosiderin-Laden Macrophage", "d": [], "t": []}, {"i": "SNOMEDCT:81236001", "l": "", "d": [], "t": []}], "preferred_name": "Hemosiderin-laden macrophage", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5216283", "l": "Myelocytes|NCnc|Pt|Bld", "d": [], "t": []}], "preferred_name": "Myelocytes|NCnc|Pt|Bld", "taxa": []}
{"type": "biolink:Cell", "ic": 69.29279780284183, "identifiers": [{"i": "CL:0000166", "l": "chromaffin cell", "d": ["A cell that stores epinephrine secretory vesicles. During times of stress, the nervous system signals the vesicles to secrete their hormonal content. Their name derives from their ability to stain a brownish color with chromic salts. Characteristically, they are located in the adrenal medulla and paraganglia of the sympathetic nervous system."], "t": []}, {"i": "UMLS:C0376604", "l": "Chromaffin Cells", "d": [], "t": []}, {"i": "NCIT:C12554", "l": "Chromaffin Cell", "d": ["Neuroendocrine cells, found in the medulla of the adrenal gland and other sympathetic nervous system ganglia, that release catecholamines into circulation."], "t": []}, {"i": "MESH:D019439", "l": "Chromaffin Cells", "d": [], "t": []}], "preferred_name": "chromaffin cell", "taxa": []}
{"type": "biolink:Cell", "ic": 86.30756602822301, "identifiers": [{"i": "CL:0000832", "l": "eosinophilic myeloblast", "d": ["A myeloblast committed to the eosinophil lineage."], "t": []}], "preferred_name": "eosinophilic myeloblast", "taxa": []}
{"type": "biolink:Cell", "ic": 66.58166100488529, "identifiers": [{"i": "CL:0002368", "l": "respiratory tract epithelial cell", "d": ["An epithelial cell of the respiratory tract epithelium.  These cells have an endodermal origin."], "t": []}], "preferred_name": "respiratory tract epithelial cell", "taxa": []}
{"type": "biolink:Cell", "ic": 86.30756602822301, "identifiers": [{"i": "CL:0002070", "l": "type I vestibular sensory cell", "d": ["Bottle-shaped with narrow neck; broad, rounded basal portion where nucleus is located; stereocilia and a single kinocilium is present apically; receive nerve bouton at their base from an afferent cup-shaped (chalice or calyx) nerve ending."], "t": []}, {"i": "UMLS:C2328961", "l": "Type 1 vestibular sensory cell", "d": [], "t": []}, {"i": "NCIT:C12630", "l": "Type I Hair Cell", "d": ["A flask-shaped mechanoreceptor cell that detects and transduces head movements into neural impulses and is located within the vestibular systems of mammals, birds, and reptiles."], "t": []}, {"i": "SNOMEDCT:2246008", "l": "", "d": [], "t": []}], "preferred_name": "type I vestibular sensory cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5885145", "l": "Cells.chromosome region 1q21 duplication", "d": [], "t": []}], "preferred_name": "Cells.chromosome region 1q21 duplication", "taxa": []}
{"type": "biolink:Cell", "ic": 87.18682603146104, "identifiers": [{"i": "UMLS:C1711264", "l": "Polyhedral Melanocyte", "d": [], "t": []}, {"i": "NCIT:C54079", "l": "Polyhedral Melanocyte", "d": [], "t": []}], "preferred_name": "Polyhedral Melanocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 88.20185721311867, "identifiers": [{"i": "UMLS:C1707939", "l": "Neoplastic Epithelioid Smooth Muscle Cell", "d": [], "t": []}, {"i": "NCIT:C49117", "l": "Neoplastic Epithelioid Smooth Muscle Cell", "d": [], "t": []}], "preferred_name": "Neoplastic Epithelioid Smooth Muscle Cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5142688", "l": "Plasma cells.abnormal marker pattern", "d": [], "t": []}], "preferred_name": "Plasma cells.abnormal marker pattern", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4033055", "l": "airway submucosal gland duct multiciliated cell", "d": ["A multi-ciliated epithelial cell located in ciliated duct of an airway submucosal gland, characterized by a columnar shape and motile cilia on its apical surface."], "t": []}], "preferred_name": "airway submucosal gland duct multiciliated cell", "taxa": []}
{"type": "biolink:Cell", "ic": 92.76600187037766, "identifiers": [{"i": "CL:0002241", "l": "pulmonary interstitial fibroblast", "d": ["A fibroblasts found in interstitial spaces in the pulmonary tract. Greater numbers of these cells are found in idiopathic pulmonary fibrosis."], "t": []}, {"i": "UMLS:C2335231", "l": "Pulmonary interstitial fibroblast", "d": [], "t": []}], "preferred_name": "pulmonary interstitial fibroblast", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4023056", "l": "vascular leptomeningeal cell (Mmus)", "d": ["A type of mouse mesothelial fibroblast that is derived from the neural crest, is localized on blood vessels, and is a key component of the pia and arachnoid membranes surrounding the brain."], "t": []}], "preferred_name": "vascular leptomeningeal cell (Mmus)", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "CL:1000715", "l": "kidney cortex collecting duct intercalated cell", "d": ["Any renal intercalated cell that is part of some cortical collecting duct."], "t": []}], "preferred_name": "kidney cortex collecting duct intercalated cell", "taxa": []}
{"type": "biolink:Cell", "ic": 88.20185721311867, "identifiers": [{"i": "UMLS:C1881225", "l": "Medium Size Melanoma Cell", "d": [], "t": []}, {"i": "NCIT:C54163", "l": "Medium Size Melanoma Cell", "d": [], "t": []}], "preferred_name": "Medium Size Melanoma Cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "MESH:D033661", "l": "Oocysts", "d": [], "t": []}], "preferred_name": "Oocysts", "taxa": []}
{"type": "biolink:Cell", "ic": 89.40238429118027, "identifiers": [{"i": "CL:0002256", "l": "supporting cell of carotid body", "d": ["A supportive cell that has characteristics of glial cell. Processes of this cell envelope the junctions between glomus cells and nerve endings."], "t": []}, {"i": "UMLS:C0229572", "l": "Supporting cell of carotid body", "d": [], "t": []}, {"i": "SNOMEDCT:37269007", "l": "", "d": [], "t": []}], "preferred_name": "supporting cell of carotid body", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1268006", "l": "Neutrophilic granulocytic cell", "d": [], "t": []}, {"i": "SNOMEDCT:127913001", "l": "", "d": [], "t": []}], "preferred_name": "Neutrophilic granulocytic cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5173433", "l": "Monocytes | Cerebral spinal fluid | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Monocytes | Cerebral spinal fluid | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4733231", "l": "MFE23 scFv-expressing autologous anti-CEA MFEz T lymphocytes", "d": [], "t": []}], "preferred_name": "MFE23 scFv-expressing autologous anti-CEA MFEz T lymphocytes", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C4687450", "l": "Autologous TCR-engineered T-cells IMA201", "d": [], "t": []}, {"i": "NCIT:C146779", "l": "Autologous TCR-engineered T-cells IMA201", "d": ["A preparation of autologous T-lymphocytes that are genetically modified with a lentiviral vector encoding a T-cell receptor (TCR) specific for an as of yet not identified tumor-associated antigen (TAA), with potential antineoplastic activity. Upon intravenous administration back into the patient, the autologous TCR-engineered T-cells IMA201 specifically recognize and bind to the TAA on cancer cells, which induces a cytotoxic T-lymphocyte (CTL)-mediated immune response against the TAA-positive cancer cells."], "t": []}], "preferred_name": "Autologous TCR-engineered T-cells IMA201", "taxa": []}
{"type": "biolink:Cell", "ic": 88.20185721311867, "identifiers": [{"i": "CL:0000422", "l": "mitogenic signaling cell", "d": ["A cell whose primary function is to cause growth by stimulating cell division in its immediate cellular environment."], "t": []}], "preferred_name": "mitogenic signaling cell", "taxa": []}
{"type": "biolink:Cell", "ic": 90.871710685482, "identifiers": [{"i": "CL:1000143", "l": "lung goblet cell", "d": ["Any goblet cell that is part of some lung epithelium."], "t": []}], "preferred_name": "lung goblet cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1267842", "l": "Lymphocyte positive for both CD4 antigen and CD69 antigen", "d": [], "t": []}, {"i": "SNOMEDCT:117529003", "l": "", "d": [], "t": []}], "preferred_name": "Lymphocyte positive for both CD4 antigen and CD69 antigen", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0019028", "l": "midzonal region hepatocyte", "d": ["Any hepatocyte that is part of the liver lobule midzonal region. These cells have mixed functionality in comparison with those in the other two regions of the liver lobule."], "t": []}], "preferred_name": "midzonal region hepatocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C0229633", "l": "myeloblast", "d": [], "t": []}, {"i": "NCIT:C13015", "l": "Myeloblast", "d": ["An immature cell that represents the first stage in the granulocytic series of hematopoiesis. It is found in bone marrow and differentiates into a promyelocyte. Its nucleus is composed of very fine, evenly distributed chromatin with 2-5 nucleoli. The cytoplasm is basophilic and non-granular."], "t": []}, {"i": "SNOMEDCT:15622002", "l": "", "d": [], "t": []}], "preferred_name": "myeloblast", "taxa": []}
{"type": "biolink:Cell", "ic": 76.9766555310214, "identifiers": [{"i": "UMLS:C1519460", "l": "Neoplastic Spindle-Shaped Myofibroblast", "d": [], "t": []}, {"i": "NCIT:C36957", "l": "Neoplastic Spindle-Shaped Myofibroblast", "d": [], "t": []}], "preferred_name": "Neoplastic Spindle-Shaped Myofibroblast", "taxa": []}
{"type": "biolink:Cell", "ic": 64.13503802424573, "identifiers": [{"i": "UMLS:C1519839", "l": "Urothelial Cell", "d": [], "t": []}, {"i": "NCIT:C33841", "l": "Urothelial Cell", "d": ["A cell found in the layer of transitional epithelium in the wall of the bladder, ureter, and renal pelvis, external to the lamina propria."], "t": []}], "preferred_name": "Urothelial Cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4510909", "l": "Blast cell positive for CD34 antigen", "d": [], "t": []}, {"i": "SNOMEDCT:725170002", "l": "", "d": [], "t": []}], "preferred_name": "Blast cell positive for CD34 antigen", "taxa": []}
{"type": "biolink:Cell", "ic": 83.63771255585968, "identifiers": [{"i": "UMLS:C1522703", "l": "Mouse Lymphocyte", "d": [], "t": []}, {"i": "NCIT:C22572", "l": "Mouse Lymphocyte", "d": [], "t": []}], "preferred_name": "Mouse Lymphocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 86.30756602822301, "identifiers": [{"i": "CL:1000458", "l": "melanocyte of skin", "d": ["A melanocyte that is part of the skin of body."], "t": []}], "preferred_name": "melanocyte of skin", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4052013", "l": "externa theca cell", "d": ["A specialized theca cell that forms the outer layer of the theca surrounding the ovarian follicle, appearing at the antral follicle. Originating from progenitor theca cells, theca externa cell is characterized by its fibroblast-like appearance and primarily function to provide structural support to the developing follicle. This cell produces collagen fibers and extracellular matrix components such as Col1a1 and Col1a2."], "t": []}], "preferred_name": "externa theca cell", "taxa": []}
{"type": "biolink:Cell", "ic": 92.76600187037766, "identifiers": [{"i": "UMLS:C1708890", "l": "Malignant Neuroectodermal Cell with Hyperchromatic Nucleus and Scanty Cytoplasm", "d": [], "t": []}, {"i": "NCIT:C54040", "l": "Malignant Neuroectodermal Cell with Hyperchromatic Nucleus and Scanty Cytoplasm", "d": [], "t": []}], "preferred_name": "Malignant Neuroectodermal Cell with Hyperchromatic Nucleus and Scanty Cytoplasm", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4072040", "l": "L6 intratelencephalic projecting Car3 glutamatergic neuron (Homo sapiens)", "d": ["A transcriptomically distinct intratelencepalic-projecting glutamatergic neuron that expresses Car3 with a soma found in L6. The standard transcriptomic reference data for this cell type can be found on the CellxGene census under the collection: 'Transcriptomic cytoarchitecture reveals principles of human neocortex organization', dataset: 'Supercluster: IT-projecting excitatory neurons', Author Categories: 'CrossArea_cluster', L6 IT Car3."], "t": []}], "preferred_name": "L6 intratelencephalic projecting Car3 glutamatergic neuron (Homo sapiens)", "taxa": []}
{"type": "biolink:Cell", "ic": 56.12547760715575, "identifiers": [{"i": "CL:0002031", "l": "hematopoietic lineage restricted progenitor cell", "d": ["A hematopoietic progenitor cell that is capable of developing into only one lineage of hematopoietic cells."], "t": []}], "preferred_name": "hematopoietic lineage restricted progenitor cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4033015", "l": "retinal astrocyte", "d": ["A star-shaped glial cell that is part of some retina. This cell links neurons to blood vessels and may provide structural and physiological support to optic nerve head axons."], "t": []}], "preferred_name": "retinal astrocyte", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5216280", "l": "Mononuclear cells|NCnc|Pt|Periton fld", "d": [], "t": []}], "preferred_name": "Mononuclear cells|NCnc|Pt|Periton fld", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0229471", "l": "Phalangeal cell of cochlea", "d": [], "t": []}, {"i": "SNOMEDCT:4799000", "l": "", "d": [], "t": []}], "preferred_name": "Phalangeal cell of cochlea", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1440389", "l": "HLA-DR+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:1373075006", "l": "", "d": [], "t": []}], "preferred_name": "HLA-DR+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "UMLS:C1513954", "l": "Neoplastic Adrenal Cortical Compact Cell", "d": [], "t": []}, {"i": "NCIT:C36931", "l": "Neoplastic Adrenal Cortical Compact Cell", "d": [], "t": []}], "preferred_name": "Neoplastic Adrenal Cortical Compact Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0002546", "l": "embryonic blood vessel endothelial progenitor cell", "d": ["An endothelial progenitor cell that participates in angiogenesis during development."], "t": []}], "preferred_name": "embryonic blood vessel endothelial progenitor cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4246841", "l": "Vagal neural crest cell", "d": [], "t": []}], "preferred_name": "Vagal neural crest cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C4527157", "l": "LMP1-specific Chimeric Antigen Receptor-expressing T Lymphocytes", "d": [], "t": []}, {"i": "NCIT:C136986", "l": "LMP1-specific Chimeric Antigen Receptor-expressing T Lymphocytes", "d": ["A preparation of cytotoxic T-lymphocytes (CTL) transfected with a chimeric antigen receptor (CAR) specifically recognizing the Epstein-Barr virus (EBV) latent membrane protein 1 (LMP1; LMP-1), with potential antineoplastic activity. Upon administration of the LMP1-specific CAR-expressing T lymphocytes to patients with LMP1-positive tumors, the CTLs specifically target and lyse tumor cells expressing LMP1, thereby inhibiting tumor cell proliferation. The tumor-associated antigen (TAA) LMP1 is expressed in various malignancies, including nasopharyngeal cancer and EBV-positive Hodgkin lymphoma."], "t": []}], "preferred_name": "LMP1-specific Chimeric Antigen Receptor-expressing T Lymphocytes", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4033183", "l": "dorsal root ganglion SP neuron", "d": ["A sensory neuron that has the soma located in the dorsal root ganglion and expresses the marker protachykinin-1 (substance P). This peptidergic nociceptor subpopulation is involved in pain signaling and neurogenic inflammation."], "t": []}], "preferred_name": "dorsal root ganglion SP neuron", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0000587", "l": "cold sensing thermoreceptor cell", "d": ["A thermoreceptor cell that detects reduced temperatures."], "t": []}], "preferred_name": "cold sensing thermoreceptor cell", "taxa": []}
{"type": "biolink:Cell", "ic": 64.24955689095262, "identifiers": [{"i": "UMLS:C1513998", "l": "Neoplastic Large Cell with Abundant Cytoplasm", "d": [], "t": []}, {"i": "NCIT:C37107", "l": "Neoplastic Large Cell with Abundant Cytoplasm", "d": [], "t": []}], "preferred_name": "Neoplastic Large Cell with Abundant Cytoplasm", "taxa": []}
{"type": "biolink:Cell", "ic": 80.27409497666227, "identifiers": [{"i": "UMLS:C1517540", "l": "Giant Astrocyte", "d": [], "t": []}, {"i": "NCIT:C36842", "l": "Giant Astrocyte", "d": [], "t": []}], "preferred_name": "Giant Astrocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 92.76600187037766, "identifiers": [{"i": "CL:4023112", "l": "vestibular afferent neuron", "d": ["An afferent neuron of the vestibular system that innervate the base of the hair cell and increase or decrease their neural firing rate as the receptor cell is excited or inhibited."], "t": []}], "preferred_name": "vestibular afferent neuron", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4079033", "l": "thoracic dorsal root ganglion peripherin neuron", "d": ["A small-diameter sensory neuron whose soma is located in the thoracic dorsal root ganglion and that expresses peripherin (encoded by PRPH), a type III intermediate filament protein. This neuron is unmyelinated, conducts action potentials as a C-fiber, and encompasses nociceptive and thermoceptive functional subpopulations. In human DRG, peripherin-immunoreactive neurons are predominantly of small diameter (Chang et al. 2018, PMID:28424991), distinguishing them from large-diameter myelinated A-fiber neurons that instead express neurofilament heavy chain (Haberberger et al. 2019, PMID:31293388). In mice, peripherin similarly marks unmyelinated primary afferent neurons."], "t": []}], "preferred_name": "thoracic dorsal root ganglion peripherin neuron", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1115669", "l": "Lymphocytes.clefted", "d": [], "t": []}], "preferred_name": "Lymphocytes.clefted", "taxa": []}
{"type": "biolink:Cell", "ic": 92.76600187037766, "identifiers": [{"i": "CL:4301625", "l": "border associated macrophage (Mmus)", "d": ["A border associated macrophage of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Mrc1 (Mmus), Maf (Mmus). Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Supertype:1195 BAM NN_1."], "t": []}], "preferred_name": "border associated macrophage (Mmus)", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C3542977", "l": "Ependymoglial Cells", "d": [], "t": []}, {"i": "MESH:D063928", "l": "Ependymoglial Cells", "d": [], "t": []}], "preferred_name": "Ependymoglial Cells", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1525452", "l": "CD11b+CD11c+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:1372960009", "l": "", "d": [], "t": []}], "preferred_name": "CD11b+CD11c+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1979182", "l": "Blasts.CD179a", "d": [], "t": []}], "preferred_name": "Blasts.CD179a", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5446452", "l": "Autologous CRISPR-Cas9 Modified/BCL11A Gene-disrupted Human Hematopoietic Stem and Progenitor Cells OTQ923", "d": [], "t": []}, {"i": "NCIT:C175342", "l": "Autologous CRISPR-Cas9 Modified/BCL11A Gene-disrupted Human Hematopoietic Stem and Progenitor Cells OTQ923", "d": ["A population of autologous cluster of differentiation 34 (CD34)-positive human hematopoietic stem and progenitor cells (hHSPCs) that are ex-vivo gene-edited with the clustered regularly interspaced short palindromic repeats (CRISPR)-Cas9 nuclease complex at the erythroid lineage-specific enhancer of the B-cell lymphoma/leukemia 11A (BCL11A) gene, with potential usage for transplantation in patients with sickle cell disease (SCD) and beta-thalassemia. CD34-positive HSPCs are isolated from human blood upon apheresis and are genetically modified in vitro using CRISPR/Cas9 technology to specifically disrupt the erythroid enhancer of the BCL11A gene. As BCL11A is a suppressor of fetal hemoglobin (HbF; hemoglobin F) expression, disruption of the BCL11A enhancer decreases the expression of BCL11A and stimulates the expression of HbF in erythrocytes that differentiate from CTX001. Upon infusion back into the patient following myeloablative, conditioning chemotherapy, autologous CRISPR-Cas9 modified/BCL11A enhancer-disrupted CD34+ hHSPCs CTX001 can populate the bone marrow and differentiate into a variety of blood cell types including lymphoid cells, myeloid cells and erythroblasts. The increased production of high levels of HbF in red blood cells (RBCs) compensates for the defective or reduced adult hemoglobin (Hb) in patients with SCD and beta-thalassemia. HbF is a form of the oxygen carrying Hb that is naturally present at birth and is then replaced by the adult form of hemoglobin."], "t": []}], "preferred_name": "Autologous CRISPR-Cas9 Modified/BCL11A Gene-disrupted Human Hematopoietic Stem and Progenitor Cells OTQ923", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5157507", "l": "CD36 cells | Blood | Cell markers", "d": [], "t": []}], "preferred_name": "CD36 cells | Blood | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4033071", "l": "cycling natural killer cell", "d": ["A(n) natural killer cell that is cycling."], "t": []}], "preferred_name": "cycling natural killer cell", "taxa": []}
{"type": "biolink:Cell", "ic": 92.76600187037766, "identifiers": [{"i": "CL:0000529", "l": "pigmented epithelial cell", "d": [], "t": []}], "preferred_name": "pigmented epithelial cell", "taxa": []}
{"type": "biolink:Cell", "ic": 92.76600187037766, "identifiers": [{"i": "CL:4052019", "l": "fallopian tube non-ciliated epithelial cell", "d": ["Any epithelial cell that is part of the fallopian tube and lacks cilia."], "t": []}], "preferred_name": "fallopian tube non-ciliated epithelial cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1181542", "l": "Type II cell of paraganglion", "d": [], "t": []}], "preferred_name": "Type II cell of paraganglion", "taxa": []}
{"type": "biolink:Cell", "ic": 65.99159461382159, "identifiers": [{"i": "CL:0000154", "l": "protein secreting cell", "d": ["Any secretory cell that is capable of some protein secretion."], "t": []}], "preferred_name": "protein secreting cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5420174", "l": "CD44v6-specific CAR T-cells", "d": [], "t": []}, {"i": "NCIT:C173368", "l": "CD44v6-specific CAR T-cells", "d": ["A preparation of genetically modified T-lymphocytes transduced with a lentiviral vector encoding a fourth-generation specific chimeric antigen receptor (4SCAR) specific for CD44 variant domain 6 (CD44v6), with potential immunomodulating and antineoplastic activities. Upon administration, CD44v6-specific CAR T-cells specifically recognize and kill CD44v6-expressing tumor cells. CD44, a transmembrane glycoprotein and hyaluronic acid receptor, is expressed in healthy tissue and overexpressed in numerous cancer cell types. CD44v6, the isoform containing the variant domain 6 of CD44 gene, plays a key role in tumor cell invasion, proliferation and metastasis."], "t": []}], "preferred_name": "CD44v6-specific CAR T-cells", "taxa": []}
{"type": "biolink:Cell", "ic": 52.69659018723216, "identifiers": [{"i": "UMLS:C1514049", "l": "Neoplastic Neuroepithelial Cell and Neoplastic Perineural Cell", "d": [], "t": []}, {"i": "NCIT:C41408", "l": "Neoplastic Neuroepithelial Cell and Neoplastic Perineural Cell", "d": [], "t": []}], "preferred_name": "Neoplastic Neuroepithelial Cell and Neoplastic Perineural Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4307133", "l": "BAM NN_1 Mrc1 border associated macrophage (Mmus)", "d": ["A border associated macrophage of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Mrc1 (Mmus), Pf4 (Mmus). It is distinguished from other BAM NN cells by expression of Mrc1, Pf4. These cells are located in the Medulla, Cerebellum, brain . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5313 BAM NN_1."], "t": []}], "preferred_name": "BAM NN_1 Mrc1 border associated macrophage (Mmus)", "taxa": []}
{"type": "biolink:Cell", "ic": 54.60088087118382, "identifiers": [{"i": "UMLS:C1515078", "l": "Supporting Cell of the Nervous System", "d": [], "t": []}, {"i": "NCIT:C33704", "l": "Supporting Cell of the Nervous System", "d": ["A cell that serves to provide support and protection and perhaps contribute to the nutrition of principal or other cells of the nervous system."], "t": []}], "preferred_name": "Supporting Cell of the Nervous System", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1440306", "l": "CD40+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:1372877005", "l": "", "d": [], "t": []}], "preferred_name": "CD40+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1267886", "l": "Lymphocyte positive for CD19 antigen", "d": [], "t": []}, {"i": "SNOMEDCT:116851009", "l": "", "d": [], "t": []}], "preferred_name": "Lymphocyte positive for CD19 antigen", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4086001", "l": "lisocabtagene maraleucel", "d": [], "t": []}, {"i": "SNOMEDCT:1148744000", "l": "", "d": [], "t": []}, {"i": "SNOMEDCT:1148950000", "l": "", "d": [], "t": []}], "preferred_name": "lisocabtagene maraleucel", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "CL:1001609", "l": "muscle fibroblast", "d": ["Fibroblast from muscle organ."], "t": []}], "preferred_name": "muscle fibroblast", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C4289974", "l": "Anti-CD22 CAR-expressing T Lymphocytes", "d": [], "t": []}, {"i": "NCIT:C128556", "l": "Anti-CD22 CAR-expressing T Lymphocytes", "d": ["A preparation of human T-lymphocytes transduced with a recombinant viral vector encoding a chimeric T-cell receptor (chimeric antigen receptor or CAR) consisting of one or more binding domains targeting the tumor-associated antigen (TAA) CD22 and fused to one or more co-stimulatory, TCR-signaling domains, with potential immunostimulating and antineoplastic activities. Upon administration, the anti-CD22 CAR-expressing T-lymphocytes, express anti-CD22-CAR on their cell surfaces and bind to the CD22 antigen on tumor cell surfaces. Subsequently, CD22-expressing B-cells are lysed. CD22, a B-lineage-restricted, transmembrane phosphoglycoprotein, is expressed on malignant B-cells."], "t": []}], "preferred_name": "Anti-CD22 CAR-expressing T Lymphocytes", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1440370", "l": "CD94+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:1372944005", "l": "", "d": [], "t": []}], "preferred_name": "CD94+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5706536", "l": "Autologous MuSK-CD3z/4-1BB-expressing Chimeric Autoantibody Receptor T-cells MuSK-CAART", "d": [], "t": []}, {"i": "NCIT:C189084", "l": "Autologous MuSK-CD3z/4-1BB-expressing Chimeric Autoantibody Receptor T-cells MuSK-CAART", "d": ["A preparation of autologous T-lymphocytes that have been engineered to express a chimeric autoantibody receptor (CAAR) containing the autoantigen muscle, skeletal receptor tyrosine-protein kinase (MuSK; muscle-specific kinase) that is fused to the co-stimulatory domain of 4-1BB (CD137) and the T-cell receptor signaling domain of CD3zeta (CD3z), with potential immunomodulatory activity. Upon administration, the autologous MuSK-CD3z/4-1BB-expressing CAAR T-cells MuSK-CAART specifically recognize and induce selective toxicity in aberrant B-cells expressing MuSK autoantibodies. This inhibits the production of MuSK autoantibodies. MuSK is a transmembrane protein expressed on skeletal muscle cell membrane that plays an important role in the formation and maintenance of the neuromuscular junction. MuSK autoantibodies are produced and expressed by aberrant B-cells in MuSK-associated myasthenia gravis."], "t": []}], "preferred_name": "Autologous MuSK-CD3z/4-1BB-expressing Chimeric Autoantibody Receptor T-cells MuSK-CAART", "taxa": []}
{"type": "biolink:Cell", "ic": 74.93438803193563, "identifiers": [{"i": "UMLS:C1514102", "l": "Neoplastic Stellate Cell", "d": [], "t": []}, {"i": "NCIT:C36899", "l": "Neoplastic Stellate Cell", "d": [], "t": []}], "preferred_name": "Neoplastic Stellate Cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5178308", "l": "Promyelocytes | Cerebral spinal fluid | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Promyelocytes | Cerebral spinal fluid | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0000655", "l": "secondary oocyte", "d": ["A secondary oocyte is an oocyte that has not completed meiosis II."], "t": []}, {"i": "UMLS:C0227882", "l": "Secondary oocyte", "d": [], "t": []}, {"i": "NCIT:C33523", "l": "Secondary Oocyte", "d": ["A female germ cell in which the first meiotic division is completed. The second meiotic division usually stops short of completion unless fertilization occurs."], "t": []}, {"i": "SNOMEDCT:46886002", "l": "", "d": [], "t": []}], "preferred_name": "secondary oocyte", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C6021828", "l": "Blasts.CD45", "d": [], "t": []}], "preferred_name": "Blasts.CD45", "taxa": []}
{"type": "biolink:Cell", "ic": 92.76600187037766, "identifiers": [{"i": "CL:0002268", "l": "P/D1 enteroendocrine cell", "d": ["An enteroendocrine cell that stores and secretes Ghrelin."], "t": []}], "preferred_name": "P/D1 enteroendocrine cell", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "CL:0001004", "l": "immature CD8-alpha-positive CD11b-negative dendritic cell", "d": ["Immature CD8-alpha-positive CD11b-negative dendritic cell is a CD8-alpha-positive CD11b-negative dendritic cell that is CD80-low, CD86-low, and MHCII-low."], "t": []}], "preferred_name": "immature CD8-alpha-positive CD11b-negative dendritic cell", "taxa": []}
{"type": "biolink:Cell", "ic": 81.743421370964, "identifiers": [{"i": "CL:0002370", "l": "respiratory tract goblet cell", "d": ["A simple columnar epithelial cell that secretes mucin. Rough endoplasmic reticulum, mitochondria, the nucleus, and other organelles are concentrated in the basal portion. The apical plasma membrane projects microvilli to increase surface area for secretion."], "t": []}], "preferred_name": "respiratory tract goblet cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0002592", "l": "smooth muscle cell of the coronary artery", "d": ["A smooth muscle cell of the coronary artery."], "t": []}], "preferred_name": "smooth muscle cell of the coronary artery", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5783664", "l": "Famzeretcel", "d": [], "t": []}, {"i": "NCIT:C190367", "l": "Famzeretcel", "d": [], "t": []}], "preferred_name": "Famzeretcel", "taxa": []}
{"type": "biolink:Cell", "ic": 76.22330125402472, "identifiers": [{"i": "UMLS:C1513981", "l": "Neoplastic Granulosa Cell", "d": [], "t": []}, {"i": "NCIT:C36894", "l": "Neoplastic Granulosa Cell", "d": [], "t": []}], "preferred_name": "Neoplastic Granulosa Cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C3496262", "l": "Ats cell group", "d": [], "t": []}], "preferred_name": "Ats cell group", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0008021", "l": "anterior lateral line ganglion neuron", "d": ["Any peripheral nervous system neuron that has its soma located in some anterior lateral line ganglion."], "t": []}], "preferred_name": "anterior lateral line ganglion neuron", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4322826", "l": "CD16+CD56+ T lymphocyte", "d": [], "t": []}], "preferred_name": "CD16+CD56+ T lymphocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 92.76600187037766, "identifiers": [{"i": "CL:0007000", "l": "preameloblast", "d": ["Skeletogenic cell that has the potential to develop into an ameloblast. Located in the inner enamel epithelium, these cells elongate, their nuclei shift distally (away from the dental papilla), and their cytoplasm becomes filled with organelles needed for synthesis and secretion of enamel proteins."], "t": []}], "preferred_name": "preameloblast", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1507328", "l": "Cells.G0+G1 phase", "d": [], "t": []}], "preferred_name": "Cells.G0+G1 phase", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5666873", "l": "ALLO-605", "d": [], "t": []}, {"i": "NCIT:C182066", "l": "Allogeneic Anti-BCMA CAR T Cells ALLO-605", "d": ["A preparation of allogeneic, transcription activator-like effector nuclease (TALEN)-engineered, gene-edited T-lymphocytes that have been transduced with a lentiviral vector expressing a chimeric antigen receptor (CAR) targeting the human tumor-associated antigen (TAA) B-cell maturation antigen (BCMA; tumor necrosis factor receptor superfamily member 17; TNFRSF17) and engineered to express a constitutively active chimeric cytokine receptor (CACCR), with potential immunostimulating and antineoplastic activities. Using TALEN technology, the T-cell receptor (TCR) alpha chain (TRAC) and CD52 genes are inactivated. Upon administration, the allogeneic anti-BCMA CAR T Cells ALLO-605 specifically recognize and induce selective toxicity in BCMA-expressing tumor cells. BCMA, a receptor for both a proliferation-inducing ligand (APRIL) and B-cell activating factor (BAFF), is a member of the tumor necrosis factor receptor superfamily (TNFRSF). BCMA is found on the surfaces of plasma cells, is overexpressed on malignant plasma cells and plays a key role in plasma cell proliferation and survival. Inactivation of the CD52 gene makes the modified donor T-cells resistant to an anti-CD52 monoclonal antibody treatment, that is used during lymphodepletion. The knockout of TRAC eliminates TCR expression and is intended to abrogate the potential induction of graft-versus-host disease (GvHD) by the donor T-cells. The expression of CACCR allows for intracellular cytokine activation signaling, which may enhance expansion and persistence of the CAR T cells, thereby improving long-term anti-tumor activity. In addition, the incorporated CD20-based off-switch of ALLO-605 permits selective depletion of the ALLO-605 cells when the anti-CD20 monoclonal antibody rituximab is administered. ALLO-605 can also be inactivated with dasatinib."], "t": []}], "preferred_name": "ALLO-605", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4042026", "l": "GABAergic interneuron of the anterior substantia nigra pars reticulata", "d": ["A GABAergic interneuron that has its soma in the anterior section of the substantia nigra pars reticulata. This GABAergic interneuron is characterized by the expression of Six3 and Foxp1 and it develops from Nkx6-2 expressing neuronal progenitors in the ventrolateral midbrain-diencephalon region."], "t": []}], "preferred_name": "GABAergic interneuron of the anterior substantia nigra pars reticulata", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5182775", "l": "TCR alpha beta cells | Blood | Cell markers", "d": [], "t": []}], "preferred_name": "TCR alpha beta cells | Blood | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": 83.63771255585968, "identifiers": [{"i": "UMLS:C1708860", "l": "Malignant Adenohypophysial Cell", "d": [], "t": []}, {"i": "NCIT:C45973", "l": "Malignant Adenohypophysial Cell", "d": [], "t": []}], "preferred_name": "Malignant Adenohypophysial Cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1267964", "l": "Lymphocyte positive for CD69 antigen", "d": [], "t": []}, {"i": "SNOMEDCT:117405008", "l": "", "d": [], "t": []}], "preferred_name": "Lymphocyte positive for CD69 antigen", "taxa": []}
{"type": "biolink:Cell", "ic": 80.27409497666227, "identifiers": [{"i": "CL:0000595", "l": "enucleate erythrocyte", "d": ["An erythrocyte lacking a nucleus."], "t": []}], "preferred_name": "enucleate erythrocyte", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1440372", "l": "Cells.CD96", "d": [], "t": []}], "preferred_name": "Cells.CD96", "taxa": []}
{"type": "biolink:Cell", "ic": 76.5892103226413, "identifiers": [{"i": "CL:0000897", "l": "CD4-positive, alpha-beta memory T cell", "d": ["A CD4-positive, alpha-beta T cell that has differentiated into a memory T cell."], "t": []}], "preferred_name": "CD4-positive, alpha-beta memory T cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C2324262", "l": "Secondary afferent neuron", "d": [], "t": []}], "preferred_name": "Secondary afferent neuron", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0000660", "l": "glycocalyx secreting cell", "d": ["An extracellular matrix secreting cell that secretes glycocalyx."], "t": []}], "preferred_name": "glycocalyx secreting cell", "taxa": []}
{"type": "biolink:Cell", "ic": 89.40238429118027, "identifiers": [{"i": "CL:1000453", "l": "epithelial cell of intermediate tubule", "d": ["An epithelial cell that is part of the intermediate tubule."], "t": []}, {"i": "UMLS:C1182797", "l": "Epithelial cell of intermediate tubule", "d": [], "t": []}], "preferred_name": "epithelial cell of intermediate tubule", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5854450", "l": "Autologous Anti-CEA CAR/HLA-A*02-gated Inhibitory Receptor/B2M shRNA-expressing T-lymphocytes A2B530", "d": [], "t": []}, {"i": "NCIT:C199653", "l": "Autologous Anti-CEA CAR/HLA-A*02-gated Inhibitory Receptor/B2M shRNA-expressing T-lymphocytes A2B530", "d": ["A preparation of autologous T-lymphocytes from a human leukocyte antigen (HLA)-A*02-positive donor that have been transduced with a lentiviral vector expressing an activating chimeric antigen receptor (CAR) specific for the tumor-associated antigen (TAA) carcinoembryonic antigen-related cell adhesion molecule 5 (CEA or CEACAM5), a leukocyte immunoglobulin-like receptor 1 (LIR-1)-based inhibitory receptor specific for HLA-A*02, and a short hairpin RNA (shRNA) targeting beta-2 microglobulin (B2M), with potential immunomodulating and antineoplastic activities. Upon administration, the autologous anti-CEA CAR/HLA-A*02-gated inhibitory receptor/B2M shRNA-expressing T-lymphocytes A2B530 target and bind to CEA-expressing tumor cells, thereby killing CEA-expressing tumor cells. The inhibitory receptor specific for HLA-A*02 acts as a safety switch that blocks the killing of HLA-A*02-positive CEA-expressing normal cells. HLA-A*02 is expressed on normal cells but not on tumor cells due to loss of heterozygosity (LOH). The B2M shRNA disrupts the expression of the B2M component of the HLA class I molecule. CEA, a member of the CEA family of proteins, plays a key role in cell migration, cell invasion and cell adhesion, and is overexpressed by a variety of cancer types."], "t": []}], "preferred_name": "Autologous Anti-CEA CAR/HLA-A*02-gated Inhibitory Receptor/B2M shRNA-expressing T-lymphocytes A2B530", "taxa": []}
{"type": "biolink:Cell", "ic": 67.09501193950672, "identifiers": [{"i": "UMLS:C1513962", "l": "Neoplastic Epithelial Spindle Cell", "d": [], "t": []}, {"i": "NCIT:C36849", "l": "Neoplastic Epithelial Spindle Cell", "d": [], "t": []}], "preferred_name": "Neoplastic Epithelial Spindle Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0000932", "l": "type II NK T cell secreting interferon-gamma", "d": ["A type II NK T cell that has been recently activated, secretes interferon-gamma, and has the phenotype CD69-positive and downregulated NK markers."], "t": []}], "preferred_name": "type II NK T cell secreting interferon-gamma", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5216226", "l": "Leukocytes other|NCnc|Pt|Pericard fld", "d": [], "t": []}], "preferred_name": "Leukocytes other|NCnc|Pt|Pericard fld", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4253022", "l": "Set of cells of pancreatic islet", "d": [], "t": []}], "preferred_name": "Set of cells of pancreatic islet", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0002394", "l": "CD141-positive myeloid dendritic cell", "d": ["A myeloid dendritic cell found in the blood, lymph nodes, tonsil, bone marrow, and spleen that is CD141-positive (BDCA-3), XCR1-positive, and Clec9A-positive. This cell-type can cross-present antigen to CD8-positive T cells and can produce inteferon-beta."], "t": []}], "preferred_name": "CD141-positive myeloid dendritic cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4307098", "l": "NFOL NN_2 9630013A20Rik newly formed oligodendrocyte (Mmus)", "d": ["A newly formed oligodendrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of 9630013A20Rik (Mmus), Grin2b (Mmus). It is distinguished from other NFOL NN_2 cells by expression of 9630013A20Rik, Grin2b. These cells are located in the Midbrain, Thalamus, brain . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5278 NFOL NN_2."], "t": []}], "preferred_name": "NFOL NN_2 9630013A20Rik newly formed oligodendrocyte (Mmus)", "taxa": []}
{"type": "biolink:Cell", "ic": 86.30756602822301, "identifiers": [{"i": "UMLS:C1709204", "l": "Neoplastic Spindle-Shaped Adipocyte", "d": [], "t": []}, {"i": "NCIT:C48907", "l": "Neoplastic Spindle-Shaped Adipocyte", "d": [], "t": []}], "preferred_name": "Neoplastic Spindle-Shaped Adipocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0004126", "l": "retinal ganglion cell C2 outer", "d": ["A retinal ganglion cell C outer that has symmetrical and dense dendritic dendritic tree with a large dendritic field."], "t": []}], "preferred_name": "retinal ganglion cell C2 outer", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C6022185", "l": "Epithelial cells | Pericardial fluid | Urinalysis", "d": [], "t": []}], "preferred_name": "Epithelial cells | Pericardial fluid | Urinalysis", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0333807", "l": "Macrocytic hyperchromic erythrocyte", "d": [], "t": []}, {"i": "SNOMEDCT:23305007", "l": "", "d": [], "t": []}], "preferred_name": "Macrocytic hyperchromic erythrocyte", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5175604", "l": "Other cells | Body fluid | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Other cells | Body fluid | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": 80.27409497666227, "identifiers": [{"i": "CL:0001203", "l": "CD8-positive, alpha-beta memory T cell, CD45RO-positive", "d": ["A CD8-positive, alpha-beta T cell with memory phenotype indicated by being CD45RO and CD127-positive. This cell type is also described as being CD25-negative."], "t": []}], "preferred_name": "CD8-positive, alpha-beta memory T cell, CD45RO-positive", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5856412", "l": "Autologous HPV E6/E7-targeting T-cells", "d": [], "t": []}, {"i": "NCIT:C200809", "l": "Autologous HPV E6/E7-targeting T-cells", "d": ["A preparation of autologous T-lymphocytes that are specifically reactive towards the human papillomavirus (HPV) viral oncoproteins E6 and E7, with potential immunomodulating and antineoplastic activities. Following leukapheresis and ex vivo priming and expansion, the autologous HPV E6/E7-targeting T-cells are re-introduced into the patient, where they target and kill tumor cells expressing these HPV tumor-associated antigens (TAAs). HPV E6 and E7 are overexpressed on certain tumor cell types and play key roles in tumor cell proliferation."], "t": []}], "preferred_name": "Autologous HPV E6/E7-targeting T-cells", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "UMLS:C1513745", "l": "Multinucleated Keratinocyte", "d": [], "t": []}, {"i": "NCIT:C36748", "l": "Multinucleated Keratinocyte", "d": [], "t": []}], "preferred_name": "Multinucleated Keratinocyte", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5163707", "l": "Erythrocytes | Amniotic fluid | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Erythrocytes | Amniotic fluid | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4033103", "l": "superior cervical ganglion NPY neuron", "d": ["A sympathetic neuron that has the soma located in the superior cervical ganglion and expresses the marker neuropeptide Y (NPY)."], "t": []}], "preferred_name": "superior cervical ganglion NPY neuron", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C4727342", "l": "Tumor-Infiltrating Immune Cell", "d": [], "t": []}, {"i": "NCIT:C153548", "l": "Tumor-Infiltrating Immune Cell", "d": ["Immune cells that have left the bloodstream and migrated into a tumor."], "t": []}], "preferred_name": "Tumor-Infiltrating Immune Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "CL:1000354", "l": "microfold cell of epithelium of intestinal villus", "d": ["A M cell that is part of the epithelium of intestinal villus."], "t": []}, {"i": "UMLS:C2340500", "l": "Microfold cell of epithelium of intestinal villus", "d": [], "t": []}], "preferred_name": "microfold cell of epithelium of intestinal villus", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0314592", "l": "Colony-forming unit of macrophagocytic lineage", "d": [], "t": []}, {"i": "SNOMEDCT:445092004", "l": "", "d": [], "t": []}], "preferred_name": "Colony-forming unit of macrophagocytic lineage", "taxa": []}
{"type": "biolink:Cell", "ic": 87.18682603146104, "identifiers": [{"i": "CL:4300351", "l": "CBX MLI Megf11 Gaba molecular layer interneuron (Mmus)", "d": ["A molecular layer interneuron of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Homer3 (Mmus), Tfap2b (Mmus), Sorcs3 (Mmus), Cacna1e (Mmus). Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Subclass:311 CBX MLI Megf11 Gaba."], "t": []}], "preferred_name": "CBX MLI Megf11 Gaba molecular layer interneuron (Mmus)", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C2330227", "l": "Type F cell of pancreatic acinus", "d": [], "t": []}], "preferred_name": "Type F cell of pancreatic acinus", "taxa": []}
{"type": "biolink:Cell", "ic": 84.83823963392128, "identifiers": [{"i": "UMLS:C4330475", "l": "Immune Cell", "d": [], "t": []}, {"i": "NCIT:C132890", "l": "Immune Cell", "d": ["A cell in the immune system that is involved in host defense. This category may include lymphocytes, monocytes, macrophages, neutrophils, eosinophils, basophils, mast cells, and thrombocytes. Precursor cells in these lineages may also be included."], "t": []}], "preferred_name": "Immune Cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C2362047", "l": "Macroblasts", "d": [], "t": []}], "preferred_name": "Macroblasts", "taxa": []}
{"type": "biolink:Cell", "ic": 70.74661260254285, "identifiers": [{"i": "UMLS:C1514224", "l": "Poorly Differentiated Neoplastic Astrocyte", "d": [], "t": []}, {"i": "NCIT:C37137", "l": "Poorly Differentiated Neoplastic Astrocyte", "d": [], "t": []}], "preferred_name": "Poorly Differentiated Neoplastic Astrocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:2000061", "l": "placental amniotic mesenchymal stromal cell", "d": ["Any mesenchymal stem cell that is part of a placenta."], "t": []}], "preferred_name": "placental amniotic mesenchymal stromal cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5154298", "l": "Band form neutrophils | Body fluid | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Band form neutrophils | Body fluid | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0228078", "l": "Partly differentiated neural cell", "d": [], "t": []}, {"i": "SNOMEDCT:71609000", "l": "", "d": [], "t": []}], "preferred_name": "Partly differentiated neural cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:2000024", "l": "spinal cord medial motor column neuron", "d": ["Any neuron that is part of a spinal cord medial motor column."], "t": []}], "preferred_name": "spinal cord medial motor column neuron", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5157309", "l": "CD14 blasts | XXX | Cell markers", "d": [], "t": []}], "preferred_name": "CD14 blasts | XXX | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4023019", "l": "L5/6 cck, VIP GABAergic interneuron (Mmus)", "d": ["A VIP GABAergic cortical interneuron that expresses cck. L5/6 cck cells have soma found mainly in L5 and L6 and have large axonal arborization."], "t": []}], "preferred_name": "L5/6 cck, VIP GABAergic interneuron (Mmus)", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4033016", "l": "secondary crest myofibroblast", "d": ["A myofibroblast that is part of an alveoli during alveolarization. The contractile force of this cell elongates the secondary crest, while producing a framework of elastin and tenascin. During the maturation of the septa, secondary crest myofibroblasts, together with matrix fibroblasts, secrete metalloproteinases and other ECM‐remodeling proteins to thin the septal tip ECM. The secondary crest myofibroblast continues producing elastin, eventually undergoing apoptosis during adulthood."], "t": []}], "preferred_name": "secondary crest myofibroblast", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5174620", "l": "Neutrophils | Pericardial fluid | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Neutrophils | Pericardial fluid | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5687321", "l": "Population of all eosinophilic myelocytes in portion of fluid", "d": [], "t": []}, {"i": "SNOMEDCT:1208767001", "l": "", "d": [], "t": []}], "preferred_name": "Population of all eosinophilic myelocytes in portion of fluid", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5448071", "l": "Tumor-Infiltrating T Helper 17 Cell", "d": [], "t": []}, {"i": "NCIT:C176757", "l": "Tumor-Infiltrating T Helper 17 Cell", "d": ["A T helper 17 cell that has migrated into a tumor."], "t": []}], "preferred_name": "Tumor-Infiltrating T Helper 17 Cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5770493", "l": "MB-102 CD123 CAR", "d": [], "t": []}], "preferred_name": "MB-102 CD123 CAR", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1979675", "l": "CD56+CD57+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:1373045001", "l": "", "d": [], "t": []}], "preferred_name": "CD56+CD57+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": 85.53200374075534, "identifiers": [{"i": "CL:0000735", "l": "lymph gland hemocyte", "d": ["A hemocyte that derives from the larval lymph gland."], "t": []}], "preferred_name": "lymph gland hemocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 64.10671682418592, "identifiers": [{"i": "CL:0000630", "l": "supporting cell", "d": ["A cell whose primary function is to support other cell types."], "t": []}, {"i": "UMLS:C2339194", "l": "Supporting cell", "d": [], "t": []}], "preferred_name": "supporting cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4696006", "l": "CD3+CD4+CD27+CD62L+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:1373245006", "l": "", "d": [], "t": []}], "preferred_name": "CD3+CD4+CD27+CD62L+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4033060", "l": "lactocyte type 2", "d": ["A lactocyte that highly expresses genes associated with lipid production and milk component biosynthesis."], "t": []}], "preferred_name": "lactocyte type 2", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4079037", "l": "thoracic dorsal root ganglion TRPV1 neuron", "d": ["A polymodal nociceptor whose soma is located in the thoracic dorsal root ganglion and that expresses the transient receptor potential vanilloid 1 channel (TRPV1, encoded by TRPV1). This neuron detects noxious heat above 43 degrees Celsius, protons, and endogenous lipid mediators, and is activated by capsaicin. In human DRG, TRPV1-immunoreactive neurons constitute approximately 54% of TrkA-positive neurons, significantly higher than the 35% observed in mouse (Rostock et al. 2018, PMID:29229553). These neurons are predominantly small-diameter nociceptors that innervate skin and visceral organs, where they function as primary detectors of thermal and chemical noxious stimuli."], "t": []}], "preferred_name": "thoracic dorsal root ganglion TRPV1 neuron", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5543953", "l": "MON002", "d": [], "t": []}, {"i": "MESH:C000715488", "l": "MON002", "d": [], "t": []}], "preferred_name": "MON002", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5401666", "l": "BREXUCABTAGENE", "d": [], "t": []}], "preferred_name": "BREXUCABTAGENE", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5853672", "l": "an allogeneic, fratricide-resistant genetically modified T cell transduced with a 2nd generation 4-1BB-CD3z chimeric antigen receptor targeting human CD7", "d": [], "t": []}], "preferred_name": "an allogeneic, fratricide-resistant genetically modified T cell transduced with a 2nd generation 4-1BB-CD3z chimeric antigen receptor targeting human CD7", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4697019", "l": "CD25+CD45RO+CD127low cell", "d": [], "t": []}, {"i": "SNOMEDCT:1373302001", "l": "", "d": [], "t": []}], "preferred_name": "CD25+CD45RO+CD127low cell", "taxa": []}
{"type": "biolink:Cell", "ic": 76.22330125402472, "identifiers": [{"i": "UMLS:C1514040", "l": "Neoplastic Myoepithelial Cell", "d": [], "t": []}, {"i": "NCIT:C36770", "l": "Neoplastic Myoepithelial Cell", "d": [], "t": []}], "preferred_name": "Neoplastic Myoepithelial Cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C3652636", "l": "technetium (99mTc) exametazime labelled cells", "d": [], "t": []}], "preferred_name": "technetium (99mTc) exametazime labelled cells", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0001002", "l": "mature CD8-alpha-negative CD11b-negative dendritic cell", "d": ["Mature CD8-alpha-negative CD11b-negative dendritic cell is a CD8-alpha-negative CD11b-negative dendritic cell that is CD80-high, CD86-high, MHCII-high and is CD83-positive."], "t": []}], "preferred_name": "mature CD8-alpha-negative CD11b-negative dendritic cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C3896758", "l": "MAGE-A4-specific TCR Gene-transduced Autologous T Lymphocytes TBI-1201", "d": [], "t": []}, {"i": "NCIT:C114978", "l": "MAGE-A4-specific TCR Gene-transduced Autologous T Lymphocytes TBI-1201", "d": ["Autologous human T-lymphocytes transduced with a retroviral vector encoding a T-cell receptor (TCR) specific for the human melanoma antigen A4 (MAGE-A4), with potential immunostimulatory and antineoplastic activities. Upon isolation, transduction, expansion ex vivo, and reintroduction into the patient, MAGE-A4-specific TCR gene-transduced T-lymphocytes TBI-1201 binds to tumor cells expressing MAGE-A4. This may result in both an inhibition of growth and increased cell death for MAGE-A4-expressing tumor cells. The tumor-associated antigen MAGE-A4 is overexpressed by a variety of cancer cell types."], "t": []}], "preferred_name": "MAGE-A4-specific TCR Gene-transduced Autologous T Lymphocytes TBI-1201", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C2986394", "l": "ALLOGENEIC NATURAL KILLER CELL LINE MG4101", "d": [], "t": []}, {"i": "NCIT:C94209", "l": "Allogeneic Natural Killer Cell Line MG4101", "d": ["A population of allogeneic, cytotoxic natural killer (NK) cells with potential antitumor activity. Allogeneic natural killer cell line MG4101 is derived from cells of a normal, healthy donor upon leukapheresis and activation."], "t": []}], "preferred_name": "ALLOGENEIC NATURAL KILLER CELL LINE MG4101", "taxa": []}
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{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0684135", "l": "short neurons", "d": [], "t": []}], "preferred_name": "short neurons", "taxa": []}
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{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0000315", "l": "tear secreting cell", "d": ["A cell secreting tears, the fluid secreted by the lacrimal glands. This fluid moistens the conjunctiva and cornea."], "t": []}], "preferred_name": "tear secreting cell", "taxa": []}
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{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C4724905", "l": "Autologous PD-L1/CD80/CD86-targeted CAR-T Cells", "d": [], "t": []}, {"i": "NCIT:C148216", "l": "Autologous PD-L1/CD80/CD86-targeted CAR-T Cells", "d": ["A preparation of autologous human T-lymphocytes engineered to express a chimeric antigen receptor (CAR) composed of a modified from of the human inhibitory receptor programmed cell death protein 1 (PD-1; PDCD1), in which the intracellular signal domain of PD-1 is transformed to allow for stimulatory signaling but with an intact extracellular ligand binding domain that specifically binds the tumor-associated antigen (TAA) programmed cell death-1 ligand 1 (PD-L1), and a modified form of the T-cell inhibitory receptor cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4), with a transformed intracellular signal domain to allow for stimulatory signaling, which specifically binds the B7 proteins CD80 (B7-1) and CD86 (B7-2), with potential immunostimulating and antineoplastic activities. Usually, ligand binding to PD-1 and CTLA-4 inhibits T-cell activity; however, these modified forms of PD-1 and CTLA-4 promote T-cell stimulatory signaling. Upon administration, the autologous PD-L1/CD80/CD86-targeted CAR-T cells target and bind to PD-L1 expressed on certain tumor cells and to CD80/CD86 expressed on antigen-presenting cells (APCs). This stimulates T-cell activation, T-cell proliferation and enhanced cytokine production, which induces selective toxicity in tumor cells expressing PD-L1. PD-1, found on activated T-cells, negatively regulates T-cell activity; it plays a key role in immune evasion and prevents tumor cell lysis. PD-L1 is often overexpressed on tumor cell types and plays a key role in immune evasion. The co-stimulatory molecules CD80 and CD86 play a key role in T-lymphocyte activation upon binding to CD28 upon antigen recognition; however, binding of CD80 and CD86 to wild-type CTLA-4 inhibits T-cell activity and results in T-cell exhaustion."], "t": []}], "preferred_name": "Autologous PD-L1/CD80/CD86-targeted CAR-T Cells", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5908027", "l": "FT825/ONO-8250", "d": [], "t": []}], "preferred_name": "FT825/ONO-8250", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1267873", "l": "Lymphoblast positive for CD14 antigen", "d": [], "t": []}, {"i": "SNOMEDCT:117552004", "l": "", "d": [], "t": []}], "preferred_name": "Lymphoblast positive for CD14 antigen", "taxa": []}
{"type": "biolink:Cell", "ic": 90.871710685482, "identifiers": [{"i": "UMLS:C1517810", "l": "Leukemic Natural Killer Cell", "d": [], "t": []}, {"i": "NCIT:C41070", "l": "Leukemic Natural Killer Cell", "d": [], "t": []}], "preferred_name": "Leukemic Natural Killer Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C4726569", "l": "Autologous PD1-inhibiting Anti-CD19 4-1BB CAR T Cells", "d": [], "t": []}, {"i": "NCIT:C151944", "l": "Autologous PD1-inhibiting Anti-CD19 4-1BB CAR T Cells", "d": ["A preparation of autologous T-lymphocytes that are transduced with a lentiviral vector encoding a chimeric antigen receptor (CAR) specific for the tumor-associated antigen (TAA) cluster of differentiation 19 (CD19) linked to the intracellular signaling domain of 4-1BB (CD137) that also encodes a cell-intrinsic programmed cell death 1 (PD1; PDCD1; CD279; programmed death-1) short/small hairpin RNA (shRNA)-expressing cassette, with potential immunomodulating and antineoplastic activities. Upon administration of the autologous PD1-inhibiting anti-CD19 4-1BB CAR T-cells, these cells target, bind to and induce selective toxicity in CD19-expressing tumor cells. CD19 antigen is a B-cell specific cell surface antigen expressed in all B-cell lineage malignancies. The shRNA silences expression of PD1, abrogates T-cell exhaustion, increases CAR T-cell activity and enhances tumor cytotoxicity. Expression of PD-1, an inhibitory receptor expressed on activated T-cells, plays a key role in CTL suppression, T-cell exhaustion and CTL apoptosis."], "t": []}], "preferred_name": "Autologous PD1-inhibiting Anti-CD19 4-1BB CAR T Cells", "taxa": []}
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{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5544464", "l": "Immunological Memory Cells", "d": [], "t": []}, {"i": "MESH:D000091244", "l": "Immunological Memory Cells", "d": [], "t": []}], "preferred_name": "Immunological Memory Cells", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1182622", "l": "Definitive germ cell", "d": [], "t": []}], "preferred_name": "Definitive germ cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0682696", "l": "Golgi type I neuron", "d": [], "t": []}], "preferred_name": "Golgi type I neuron", "taxa": []}
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{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1440283", "l": "CD3+CD4+CD45RA-CD45RO- cell", "d": [], "t": []}, {"i": "SNOMEDCT:1373252008", "l": "", "d": [], "t": []}], "preferred_name": "CD3+CD4+CD45RA-CD45RO- cell", "taxa": []}
{"type": "biolink:Cell", "ic": 88.20185721311867, "identifiers": [{"i": "CL:0002553", "l": "fibroblast of lung", "d": ["A fibroblast that is part of lung."], "t": []}], "preferred_name": "fibroblast of lung", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "CL:0000350", "l": "amnioserosal cell", "d": ["Any extraembryonic cell that is part of some amnioserosa."], "t": []}], "preferred_name": "amnioserosal cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0002170", "l": "keratinized cell of the oral mucosa", "d": ["A keratinized cell located in the hard palate or gingiva."], "t": []}], "preferred_name": "keratinized cell of the oral mucosa", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1440401", "l": "Cells.t(11;22)(q24;q12.2)(FLI1,EWSR1)", "d": [], "t": []}], "preferred_name": "Cells.t(11;22)(q24;q12.2)(FLI1,EWSR1)", "taxa": []}
{"type": "biolink:Cell", "ic": 54.032388867152086, "identifiers": [{"i": "CL:0001035", "l": "bone cell", "d": ["A connective tissue cell found in bone."], "t": []}, {"i": "UMLS:C0222677", "l": "Cell of bone", "d": [], "t": []}, {"i": "NCIT:C48762", "l": "Bone Cell", "d": [], "t": []}, {"i": "SNOMEDCT:3400000", "l": "", "d": [], "t": []}], "preferred_name": "bone cell", "taxa": []}
{"type": "biolink:Cell", "ic": 90.871710685482, "identifiers": [{"i": "CL:0002382", "l": "multinucleate conidium", "d": ["A conidium that has more than one nucleus."], "t": []}], "preferred_name": "multinucleate conidium", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0000719", "l": "posterior cone cell (sensu Endopterygota)", "d": [], "t": []}], "preferred_name": "posterior cone cell (sensu Endopterygota)", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4319573", "l": "Clue cell", "d": [], "t": []}, {"i": "SNOMEDCT:726573004", "l": "", "d": [], "t": []}], "preferred_name": "Clue cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1257910", "l": "Aneuploid Cell", "d": [], "t": []}], "preferred_name": "Aneuploid Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5706444", "l": "Allogeneic Anti-CD19 CAR-NK Cells QN-019a", "d": [], "t": []}, {"i": "NCIT:C188046", "l": "Allogeneic Anti-CD19 CAR-NK Cells QN-019a", "d": ["A preparation of allogeneic natural killer (NK) cells engineered to express a chimeric antigen receptor (CAR) specific for the tumor-associated antigen (TAA) cluster of differentiation 19 (CD19), with potential immunomodulating and antineoplastic activities. Upon administration, the allogeneic anti-CD19 CAR-NK cells QN-019a recognize, bind to and induce selective cytotoxicity in CD19-expressing tumor cells. CD19 is a B-cell specific cell surface antigen overexpressed in B-cell lineage malignancies."], "t": []}], "preferred_name": "Allogeneic Anti-CD19 CAR-NK Cells QN-019a", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5157599", "l": "CD5+CD20+ cells | White blood cells | Cell markers", "d": [], "t": []}], "preferred_name": "CD5+CD20+ cells | White blood cells | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5977345", "l": "Monocytes.CD169", "d": [], "t": []}], "preferred_name": "Monocytes.CD169", "taxa": []}
{"type": "biolink:Cell", "ic": 69.87704306295657, "identifiers": [{"i": "UMLS:C1514008", "l": "Neoplastic Large T-Lymphocyte", "d": [], "t": []}, {"i": "NCIT:C37016", "l": "Neoplastic Large T-Lymphocyte", "d": [], "t": []}], "preferred_name": "Neoplastic Large T-Lymphocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4307093", "l": "COP NN_1 9130019P16Rik committed oligodendrocyte precursor (Mmus)", "d": ["A committed oligodendrocyte precursor of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Gpr17 (Mmus), Gp1bb (Mmus), Pdzd2 (Mmus), Plekhg1 (Mmus). It is distinguished from other COP NN_1 cells by expression of Rgcc, 9130019P16Rik. These cells are located in the Isocortex, brain . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5273 COP NN_1."], "t": []}], "preferred_name": "COP NN_1 9130019P16Rik committed oligodendrocyte precursor (Mmus)", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4047036", "l": "stomach smooth muscle circular layer cell", "d": ["A smooth muscle cell located in the middle layer of the muscularis externa of the stomach wall. This cell is arranged concentrically with the stomach's longitudinal axis, forming a continuous sheet of contractile tissue. It is fusiform in shape, containing actin and myosin filaments that enable contraction without striations. This cell contributes to the mechanical digestion and movement of food within the stomach through coordinated contractions, and plays a role in forming the pyloric sphincter in the pyloric region."], "t": []}], "preferred_name": "stomach smooth muscle circular layer cell", "taxa": []}
{"type": "biolink:Cell", "ic": 86.30756602822301, "identifiers": [{"i": "CL:0005000", "l": "spinal cord interneuron", "d": ["A CNS interneuron located in the spinal cord."], "t": []}], "preferred_name": "spinal cord interneuron", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4052035", "l": "tuft cell of pancreatic duct", "d": ["A tuft cell that is part of the epithelium of pancreatic duct. Present in humans and rats, this cell is absent in the murine pancreas under normal conditions but emerges during acinar-to-ductal metaplasia triggered by injury, inflammation, or oncogenic mutations. It modulates the immune response and protects against pancreatic ductal adenocarcinoma progression by producing suppressive eicosanoids, such as prostaglandin D2. A tuft cell in the pancreatic duct highly expresses the transcription factor POU2F3, which is essential for its development and presence."], "t": []}], "preferred_name": "tuft cell of pancreatic duct", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1267862", "l": "Lymphocyte positive for CD10 antigen", "d": [], "t": []}, {"i": "SNOMEDCT:116848002", "l": "", "d": [], "t": []}], "preferred_name": "Lymphocyte positive for CD10 antigen", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5454842", "l": "Cells.Not specified", "d": [], "t": []}], "preferred_name": "Cells.Not specified", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0002449", "l": "CD94-positive Ly49CI-positive natural killer cell, mouse", "d": ["A NK1.1-positive T cell that is CD94-positive and Ly49Cl-positive."], "t": []}], "preferred_name": "CD94-positive Ly49CI-positive natural killer cell, mouse", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C2347257", "l": "CD3/CD28 Costimulated Autologous T-Cells", "d": [], "t": []}, {"i": "NCIT:C74017", "l": "CD3/CD28 Costimulated Autologous T-Cells", "d": ["A population of T cells that have been sensitized to vaccine tumor antigen(s) in vivo; collected from the patient; co-stimulated with antibodies to the T-cell cell surface proteins CD3 and CD28 and expanded ex vivo; and then infused into the same patient. CD3, part of the T cell receptor complex, and CD28, a T-cell surface-associated co-stimulatory molecule, are both required for full T-cell activation. Adoptive transfer of CD3/CD28 costimulated vaccine-primed autologous T-cells may induce the production of interferon-gamma (IFN-gamma) and granulocyte-macrophage colony-stimulating factor (GM-CSF) and associated antitumor effects and a graft-versus-tumor (GVT) response."], "t": []}], "preferred_name": "CD3/CD28 Costimulated Autologous T-Cells", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0524978", "l": "Intestinal Secretin Cells", "d": [], "t": []}], "preferred_name": "Intestinal Secretin Cells", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4072766", "l": "Cells.9q34 chromosome region", "d": [], "t": []}], "preferred_name": "Cells.9q34 chromosome region", "taxa": []}
{"type": "biolink:Cell", "ic": 64.66682481467028, "identifiers": [{"i": "CL:0000127", "l": "astrocyte", "d": ["A class of large neuroglial (macroglial) cells in the central nervous system - the largest and most numerous neuroglial cells in the brain and spinal cord. Astrocytes (from 'star' cells) are irregularly shaped with many long processes, including those with 'end feet' which form the glial (limiting) membrane and directly and indirectly contribute to the blood-brain barrier. They regulate the extracellular ionic and chemical environment, and 'reactive astrocytes' (along with microglia) respond to injury."], "t": []}, {"i": "UMLS:C0004112", "l": "Astrocytes", "d": [], "t": []}, {"i": "NCIT:C12477", "l": "Astrocyte", "d": ["A heterogeneous group of specialized neuroglial cells with many diverse supporting roles in the structure, function, and homeostasis of the central nervous system."], "t": []}, {"i": "MESH:D001253", "l": "Astrocytes", "d": [], "t": []}, {"i": "SNOMEDCT:78399007", "l": "", "d": [], "t": []}], "preferred_name": "astrocyte", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5157234", "l": "CD10 blasts | Blood | Cell markers", "d": [], "t": []}], "preferred_name": "CD10 blasts | Blood | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": 90.871710685482, "identifiers": [{"i": "CL:0002225", "l": "secondary lens fiber", "d": ["A lens fiber cell that develops from primary lens fiber; located towards the center of lens; cell organelles are normally degraded or in the process of being degraded."], "t": []}], "preferred_name": "secondary lens fiber", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5157485", "l": "CD33 blasts | XXX | Cell markers", "d": [], "t": []}], "preferred_name": "CD33 blasts | XXX | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4246840", "l": "Trunk neural crest cell", "d": [], "t": []}], "preferred_name": "Trunk neural crest cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0019015", "l": "lung parenchyma resident eosinophil", "d": ["An eosinophil with a ring-shaped nucleus that is resident in the lung parenchyma. In mouse, lung parenchyma resident eosinophils are IL-5-independent Siglec-F(intermediate) CD62L+ CD101(low). In human, they are Siglec-8+ CD62L+ IL-3R(low)."], "t": []}], "preferred_name": "lung parenchyma resident eosinophil", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0882920", "l": "CD7+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:116747004", "l": "", "d": [], "t": []}], "preferred_name": "CD7+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": 92.76600187037766, "identifiers": [{"i": "CL:0002201", "l": "renal beta-intercalated cell", "d": ["A renal intercalated cell that secretes base and reabsorbs acid in the distal segments of the kidney tubule to maintain acid/base balance."], "t": []}], "preferred_name": "renal beta-intercalated cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1515636", "l": "gp100 Peptide-sensitized Autologous T-cells (CD4+ and CD8+)", "d": [], "t": []}, {"i": "NCIT:C29556", "l": "gp100 Peptide-sensitized Autologous T-cells (CD4+ and CD8+)", "d": ["A population of CD4+ and CD8+ T-cells isolated from a cancer patient that have been sensitized in vitro to the melanoma-associated antigen gp100.  Infusion of gp100 peptide-sensitized autologous T-cells into the cancer patient may stimulate the host immune system to mount a cytotoxic T lymphocyte (CTL) response against gp100-positive tumor cells, thereby decreasing tumor growth. (NCI04)"], "t": []}], "preferred_name": "gp100 Peptide-sensitized Autologous T-cells (CD4+ and CD8+)", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C2985181", "l": "PSA-PAP/KLH-pulsed Autologous Dendritic Cell Vaccine", "d": [], "t": []}, {"i": "NCIT:C92573", "l": "PSA-PAP/KLH-pulsed Autologous Dendritic Cell Vaccine", "d": ["A cell-based cancer vaccine composed of autologous dendritic cells (DCs) pulsed with the prostate-specific tumor associated antigens (TAAs) prostate specific antigen (PSA) and prostate acid phosphatase (PAP), and conjugated to the immunostimulant Keyhole limpet hemocyanin (KLH), with potential immunostimulatory and antineoplastic activities. Upon administration, prostate cancer antigen/KLH-pulsed autologous dendritic cell vaccine may stimulate the immune system to mount anti-tumoral cytotoxic T lymphocyte (CTL) and antibody responses against prostate cancer cells expressing PSA and PAP, which may result in prostate cancer cell lysis. KLH is an immunogenic carrier and serves as an immunostimulant to improve antigenic immune recognition and T-cell responses and can be used to evaluate vaccine efficacy."], "t": []}], "preferred_name": "PSA-PAP/KLH-pulsed Autologous Dendritic Cell Vaccine", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4484192", "l": "Neutrophil.fMLP stimulated.DHR", "d": [], "t": []}], "preferred_name": "Neutrophil.fMLP stimulated.DHR", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4307087", "l": "OPC NN_1 Irx2 oligodendrocyte precursor cell (Mmus)", "d": ["A oligodendrocyte precursor cell of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Pdgfra (Mmus), Pclaf (Mmus), Irx2 (Mmus). It is distinguished from other OPC NN_1 cells by expression of Neil3, Irx2. These cells are located in the Cerebellum, brain, Midbrain, Pons, Medulla . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5267 OPC NN_1."], "t": []}], "preferred_name": "OPC NN_1 Irx2 oligodendrocyte precursor cell (Mmus)", "taxa": []}
{"type": "biolink:Cell", "ic": 90.871710685482, "identifiers": [{"i": "UMLS:C5702551", "l": "Vitreous Seed", "d": [], "t": []}, {"i": "NCIT:C189882", "l": "Vitreous Seed", "d": ["Tumor cells that have spread into the vitreous of the eye."], "t": []}], "preferred_name": "Vitreous Seed", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4322679", "l": "Chromosome sex pair", "d": [], "t": []}], "preferred_name": "Chromosome sex pair", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4072044", "l": "L6 corticothalamic-projecting glutamatergic cortical neuron (Homo sapiens)", "d": ["A transcriptomically distinct corticothalamic-projecting neuron with a soma found in cortical layer 6. The standard transcriptomic reference data for this cell type can be found on the CellxGene census under the collection: 'Transcriptomic cytoarchitecture reveals principles of human neocortex organization', dataset: 'Supercluster: Deep layer (non-IT) excitatory neurons', Author Categories: 'CrossArea_subclass', clusters L6 CT."], "t": []}], "preferred_name": "L6 corticothalamic-projecting glutamatergic cortical neuron (Homo sapiens)", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "UMLS:C1518367", "l": "Non-Keratinizing Malignant Large Squamous Cell", "d": [], "t": []}, {"i": "NCIT:C36793", "l": "Non-Keratinizing Malignant Large Squamous Cell", "d": [], "t": []}], "preferred_name": "Non-Keratinizing Malignant Large Squamous Cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4510925", "l": "Blast cell positive for CD20 antigen", "d": [], "t": []}, {"i": "SNOMEDCT:725174006", "l": "", "d": [], "t": []}], "preferred_name": "Blast cell positive for CD20 antigen", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4086007", "l": "Audencel", "d": [], "t": []}], "preferred_name": "Audencel", "taxa": []}
{"type": "biolink:Cell", "ic": 81.34422831136257, "identifiers": [{"i": "CL:0000752", "l": "cone retinal bipolar cell", "d": ["A bipolar neuron found in the retina and having connections with cone photoreceptor cells and neurons in the inner plexiform layer."], "t": []}], "preferred_name": "cone retinal bipolar cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1180272", "l": "Myoepithelial cell of lactiferous duct", "d": [], "t": []}], "preferred_name": "Myoepithelial cell of lactiferous duct", "taxa": []}
{"type": "biolink:Cell", "ic": 92.76600187037766, "identifiers": [{"i": "CL:1000491", "l": "mesothelial cell of pleura", "d": ["A mesothelial cell that is part of the pleura."], "t": []}], "preferred_name": "mesothelial cell of pleura", "taxa": []}
{"type": "biolink:Cell", "ic": 76.9766555310214, "identifiers": [{"i": "UMLS:C1522060", "l": "Epithelioid Melanoma Cell", "d": [], "t": []}, {"i": "NCIT:C36872", "l": "Epithelioid Melanoma Cell", "d": [], "t": []}], "preferred_name": "Epithelioid Melanoma Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 81.743421370964, "identifiers": [{"i": "CL:1000616", "l": "kidney outer medulla cell", "d": ["Any kidney medulla cell that is part of some outer medulla of kidney."], "t": []}], "preferred_name": "kidney outer medulla cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C4682857", "l": "BB 21217", "d": [], "t": []}, {"i": "NCIT:C140310", "l": "Autologous Anti-BCMA-CAR-4-1BB-CD3zeta-expressing Memory T-lymphocytes bb21217", "d": ["A preparation of autologous memory T-lymphocytes transduced, ex vivo, with a lentiviral vector expressing a chimeric antigen receptor (CAR) containing an anti-B-cell maturation antigen (BCMA) single chain variable fragment (scFv) fused to the signaling domain of 4-1BB (CD137) and a CD3-zeta T-cell activation domain, with potential immunostimulating and antineoplastic activities. Upon intravenous administration back into the patient, the autologous anti-BCMA-CAR-4-1BB-CD3zeta-expressing memory T-lymphocytes bb21217 are directed to, and induce selective toxicity in, BCMA-expressing tumor cells. BCMA, a tumor specific antigen and a receptor for both a proliferation-inducing ligand (APRIL) and B-cell activating factor (BAFF), is a member of the tumor necrosis factor receptor superfamily (TNFRSF) and plays a key role in plasma survival. BCMA is overexpressed on malignant plasma cells."], "t": []}], "preferred_name": "BB 21217", "taxa": []}
{"type": "biolink:Cell", "ic": 84.83823963392128, "identifiers": [{"i": "CL:0002357", "l": "fetal derived definitive erythrocyte", "d": ["A fetal liver derived enucleated erythrocyte. This erythrocyte resembles adult erythrocytes in that they are small (3- to 6- times smaller than primitive erythrocytes) and produce adult hemaglobins."], "t": []}], "preferred_name": "fetal derived definitive erythrocyte", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1440050", "l": "Abnormal blood cells.CD14", "d": [], "t": []}], "preferred_name": "Abnormal blood cells.CD14", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1267905", "l": "Lymphocyte positive for CD32 antigen", "d": [], "t": []}, {"i": "SNOMEDCT:117576007", "l": "", "d": [], "t": []}], "preferred_name": "Lymphocyte positive for CD32 antigen", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C0018497", "l": "Inner Auditory Hair Cells", "d": [], "t": []}, {"i": "NCIT:C32805", "l": "Inner Hair Cell of the Organ of the Corti", "d": ["A cell situated on the inner most layer of the basilar membrane of the cochlea. Each cell has multiple, sensitive strands called stereocilia. In the resting state the stereocilia are leaning on each other in a conical bundle and touch the tectorial membrane. When the cochlea moves in response to sound, a slight shearing force occurs between the basilar and tectorial membranes, the stereocilia bend and send electrical impulses to the brain via the eighth cranial nerve."], "t": []}, {"i": "MESH:D006199", "l": "Hair Cells, Auditory, Inner", "d": [], "t": []}, {"i": "SNOMEDCT:11520008", "l": "", "d": [], "t": []}], "preferred_name": "Inner Auditory Hair Cells", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5157290", "l": "CD127 blasts | Bone marrow | Cell markers", "d": [], "t": []}], "preferred_name": "CD127 blasts | Bone marrow | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0002409", "l": "mature Vgamma2-negative thymocyte", "d": ["A thymocyte that has a T cell receptor consisting of a gamma chain that does not contain the Vgamma2 segment, and a delta chain. This cell type is CD4-negative, CD8-negative and CD24-negative."], "t": []}], "preferred_name": "mature Vgamma2-negative thymocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5666822", "l": "Squeezed Red Blood Cells Expressing HPV16 Epitopes SQZ-AAC-HPV", "d": [], "t": []}, {"i": "NCIT:C184978", "l": "Squeezed Red Blood Cells Expressing HPV16 Epitopes SQZ-AAC-HPV", "d": ["A cell therapy agent composed of autologous red blood cells (RBCs) engineered to act as artificial antigen carriers (AACs) and expressing tumor-specific antigens (TAAs), human papillomavirus (HPV) type 16 epitopes, and containing a Toll-like receptor (TLR) agonist as an activating adjuvant, with potential immunomodulating and antineoplastic activities. Using cell squeeze technology, the RBCs are squeezed (SQZ) and loaded with TAAs and an adjuvant to generate SQZ AACs that appear similar to aged RBCs. Upon administration of the SQZ RBCs expressing HPV16 epitopes SQZ-AAC-HPV, the SQZ RBCs are rapidly taken up by the patient's professional antigen-presenting cells (APCs) similar to the process of natural clearance and destruction of aged RBCs. In turn, the HPV16 epitopes are presented to the immune system and activate the immune system to mount a cytotoxic T-lymphocyte (CTL) immune response against tumor cells expressing HPV16. By mimicking natural aged RBCs, the AACs are able to activate an anti-tumor immune response against the TAA-expressing tumor cells. HPV16 plays an important role in the development of certain types of cancer."], "t": []}], "preferred_name": "Squeezed Red Blood Cells Expressing HPV16 Epitopes SQZ-AAC-HPV", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5163549", "l": "Epithelial cells.non-squamous | Urine | Urinalysis", "d": [], "t": []}], "preferred_name": "Epithelial cells.non-squamous | Urine | Urinalysis", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5173500", "l": "Mononuclear cells | Synovial fluid | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Mononuclear cells | Synovial fluid | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0009113", "l": "T follicular regulatory cell", "d": ["A regulatory T cell present in the B cell follicles and germinal centers of lymphoid tissues. In humans, it is CXCR5+."], "t": []}], "preferred_name": "T follicular regulatory cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4033006", "l": "endothelial cell of efferent lymphatic vessel", "d": ["A(n) endothelial cell that is part of a(n) efferent lymphatic vessel."], "t": []}], "preferred_name": "endothelial cell of efferent lymphatic vessel", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5667586", "l": "Autologous Desmoglein-3 Chimeric Autoantibody Receptor T-cells DSG3-CAART", "d": [], "t": []}, {"i": "NCIT:C182441", "l": "Autologous Desmoglein-3 Chimeric Autoantibody Receptor T-cells DSG3-CAART", "d": ["A preparation of autologous T-lymphocytes that have been engineered to express a chimeric autoantibody receptor (CAAR) containing the autoantigen desmoglein-3 (desmoglein 3; DSG3) that is fused to the co-stimulatory domain of 4-1BB (CD137) and the T-cell receptor signaling domain of CD3zeta (CD3z), with potential immunomodulatory activity. Upon administration, the autologous DSG3 chimeric autoantibody receptor T-cells (CAART) DSG3-CAART specifically recognize and induce selective toxicity in aberrant B-cells expressing DSG3 autoantibodies. This inhibits the production of DSG3 autoantibodies. DSG3 is a protein expressed in desmosomes that plays an important role in cell adhesion. DSG3 autoantibodies are produced and expressed by aberrant B-cells in the autoimmune disease mucosal-dominant pemphigus vulgaris."], "t": []}], "preferred_name": "Autologous Desmoglein-3 Chimeric Autoantibody Receptor T-cells DSG3-CAART", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1317328", "l": "Immature eosinophils", "d": [], "t": []}, {"i": "SNOMEDCT:655131010000108", "l": "", "d": [], "t": []}], "preferred_name": "Immature eosinophils", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4052049", "l": "striated cell of salivary gland", "d": ["An columnar/cuboidal epithelial cell that is part of the striated duct of salivary gland, characterized by basal striations formed by infoldings of the plasma membrane. This cell play a crucial role in modifying the electrolyte composition and concentration of saliva through active ion transport, particularly the absorption of sodium and secretion of potassium."], "t": []}], "preferred_name": "striated cell of salivary gland", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5392177", "l": "Satellite Glia", "d": [], "t": []}], "preferred_name": "Satellite Glia", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1440300", "l": "CD36+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:1372874003", "l": "", "d": [], "t": []}], "preferred_name": "CD36+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:1000434", "l": "epithelial cell of external acoustic meatus", "d": ["An epithelial cell that is part of the external acoustic meatus."], "t": []}, {"i": "UMLS:C1182614", "l": "Epithelial cell of external acoustic meatus", "d": [], "t": []}], "preferred_name": "epithelial cell of external acoustic meatus", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5163235", "l": "Elliptocytes | Blood | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Elliptocytes | Blood | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4030061", "l": "L3 intratelencephalic projecting glutamatergic neuron", "d": ["An intratelencephalic-projecting glutamatergic neuron with a soma found in cortical layer 3."], "t": []}], "preferred_name": "L3 intratelencephalic projecting glutamatergic neuron", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0009090", "l": "endothelial colony forming cell", "d": ["An adult endothelial progenitor cell that is resident of adult vasculature and capable of differentiating to regenerate endothelial cell populations. Endothelial colony forming cells are characterised in vivo by clonal proliferative status, de novo vessel formation, homing to ischemic sites and paracrine support of angiogenesis. These cells are phenotypically similar to endothelial cells."], "t": []}], "preferred_name": "endothelial colony forming cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5157359", "l": "CD19+IgM+ cells | Blood | Cell markers", "d": [], "t": []}], "preferred_name": "CD19+IgM+ cells | Blood | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": 74.11023018174025, "identifiers": [{"i": "UMLS:C1519000", "l": "Peripheral Epidermotropic T-Lymphocyte", "d": [], "t": []}, {"i": "NCIT:C38323", "l": "Peripheral Epidermotropic T-Lymphocyte", "d": [], "t": []}], "preferred_name": "Peripheral Epidermotropic T-Lymphocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4033174", "l": "ovarian nerve plexus ganglion TH neuron", "d": ["A sympathetic neuron that has the soma located in the ovarian nerve plexus ganglion and expresses the marker tyrosine hydroxylase (TH)."], "t": []}], "preferred_name": "ovarian nerve plexus ganglion TH neuron", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5417934", "l": "CTX120", "d": [], "t": []}], "preferred_name": "CTX120", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1947989", "l": "Colony (cells or organisms)", "d": [], "t": []}, {"i": "NCIT:C61515", "l": "Colony", "d": ["A group of cells or organisms grown from a single progenitor."], "t": []}], "preferred_name": "Colony (cells or organisms)", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5170451", "l": "Lambda lymphocytes | Blood | Cell markers", "d": [], "t": []}], "preferred_name": "Lambda lymphocytes | Blood | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5157473", "l": "CD3+TCR gamma delta+ cells | Blood | Cell markers", "d": [], "t": []}], "preferred_name": "CD3+TCR gamma delta+ cells | Blood | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": 80.96785908349635, "identifiers": [{"i": "UMLS:C1512944", "l": "Intraepithelial Lymphocytes", "d": [], "t": []}, {"i": "NCIT:C38331", "l": "Intraepithelial T-Lymphocyte", "d": ["A mature T lymphocyte that migrates into epithelial tissue and contributes to the local and the systemic immune response."], "t": []}, {"i": "MESH:D000075942", "l": "Intraepithelial Lymphocytes", "d": [], "t": []}], "preferred_name": "Intraepithelial Lymphocytes", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5186954", "l": "Promyelocytes | Fetus | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Promyelocytes | Fetus | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": 67.8984399852903, "identifiers": [{"i": "CL:0000182", "l": "hepatocyte", "d": ["The main structural component of the liver. They are specialized epithelial cells that are organized into interconnected plates called lobules. Majority of cell population of liver, polygonal in shape, arranged in plates or trabeculae between sinusoids; may have single nucleus or binucleated."], "t": []}, {"i": "UMLS:C0227525", "l": "Hepatocyte", "d": [], "t": []}, {"i": "NCIT:C12588", "l": "Hepatocyte", "d": ["A parenchymal liver cell."], "t": []}, {"i": "MESH:D022781", "l": "Hepatocytes", "d": [], "t": []}, {"i": "SNOMEDCT:30396005", "l": "", "d": [], "t": []}], "preferred_name": "hepatocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "UMLS:C1708910", "l": "Malignant Smooth Muscle Cell with Granular Cytoplasmic Change", "d": [], "t": []}, {"i": "NCIT:C49128", "l": "Malignant Smooth Muscle Cell with Granular Cytoplasmic Change", "d": [], "t": []}], "preferred_name": "Malignant Smooth Muscle Cell with Granular Cytoplasmic Change", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0000416", "l": "polytene cell", "d": [], "t": []}], "preferred_name": "polytene cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4033009", "l": "goblet cell of epithelium of lobar bronchus", "d": ["A(n) goblet cell that is part of a(n) epithelium of lobar bronchus."], "t": []}], "preferred_name": "goblet cell of epithelium of lobar bronchus", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5180579", "l": "Segmented neutrophils | Synovial fluid | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Segmented neutrophils | Synovial fluid | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": 73.613037951824, "identifiers": [{"i": "UMLS:C1510728", "l": "Abnormal Keratinocyte", "d": [], "t": []}, {"i": "NCIT:C36766", "l": "Abnormal Keratinocyte", "d": [], "t": []}], "preferred_name": "Abnormal Keratinocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C4723730", "l": "Anti-K-RAS G12D mTCR-transduced Autologous Peripheral Blood Lymphocytes", "d": [], "t": []}, {"i": "NCIT:C156889", "l": "Anti-K-RAS G12D mTCR-transduced Autologous Peripheral Blood Lymphocytes", "d": ["Autologous peripheral blood lymphocytes (PBLs) transduced with a retroviral vector encoding for an HLA class I histocompatibility antigen A*11:01 (HLA-A1101)-restricted murine T-cell receptor (mTCR) that recognizes the glycine (Gly, G) to aspartic acid (Asp, D) point mutation at position 12 (G12D) variant of K-RAS (KRAS), with potential immunomodulating and antineoplastic activities. HLA-A1101-positive PBLs are harvested from a K-RAS G12D-expressing cancer patient and transfected with a retroviral vector that encodes anti-K-RAS G12D mTCR. The transduced PBLs are then expanded in culture. When reintroduced to the patient, these anti-K-RAS G12D mTCR-expressing PBLs target and bind to K-RAS G12D-overexpressing tumor cells, which results in both cytokine secretion, including interferon-gamma (IFN-g), and tumor cell lysis. K-RAS, a member of the RAS family of oncogenes, serves an important role in cell signaling, division and differentiation. Mutation of K-RAS may induce constitutive signal transduction leading to tumor cell growth, proliferation, invasion, and metastasis."], "t": []}], "preferred_name": "Anti-K-RAS G12D mTCR-transduced Autologous Peripheral Blood Lymphocytes", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4072013", "l": "A16 dopaminergic neuron", "d": ["A type of dopaminergic interneuron located in the glomerular layer of the main olfactory bulb, characterized by the co-release of dopamine and GABA, and involved in modulating sensory input within olfactory circuits."], "t": []}], "preferred_name": "A16 dopaminergic neuron", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5238954", "l": "PBCAR20A", "d": [], "t": []}, {"i": "NCIT:C168570", "l": "Allogeneic Anti-CD20-CAR T-cells PBCAR20A", "d": ["A preparation of allogeneic, off-the-shelf (OTS), T-lymphocytes, derived from healthy donors, that have been genetically modified using a proprietary synthetic endonuclease-based system to express a chimeric antigen receptor (CAR) targeting the tumor-associated antigen (TAA) CD20 (cluster of differentiation 20), with potential immunostimulating and antineoplastic activities. Upon administration, allogeneic anti-CD20-CAR T-cells PBCAR20A specifically recognize and kill CD20-expressing tumor cells. The CD20 antigen, a non-glycosylated cell surface phosphoprotein, is a B-cell specific cell surface antigen expressed in B-cell lineage malignancies."], "t": []}], "preferred_name": "PBCAR20A", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5849119", "l": "Autologous Anti-GPC3-CAR T-lymphocytes Ori-C101", "d": [], "t": []}, {"i": "NCIT:C199285", "l": "Autologous Anti-GPC3-CAR T-lymphocytes Ori-C101", "d": ["A preparation of autologous T-lymphocytes that have been genetically modified to express a chimeric antigen receptor (CAR) specific for glypican-3 (GPC3) and a signal activation domain element, Ori, with potential immunostimulating and antineoplastic activities. Upon administration, autologous anti-GPC3-CAR T-lymphocytes Ori-C101 specifically target and bind to GPC3-expressing tumor cells, resulting in tumor cell lysis. GPC3, a heparan sulfate proteoglycan (HSPG) and a member of the glypican family, is overexpressed on certain tumor cell types while minimally expressed on normal, healthy cells. GPC3 plays an important role in cellular proliferation and differentiation. Ori is able to enhance the expansion of memory T-cells, abrogate the immunosuppressive tumor microenvironment (TME), and may enhance the anti-tumor activity and durability of CAR T-cells Ori-C101."], "t": []}], "preferred_name": "Autologous Anti-GPC3-CAR T-lymphocytes Ori-C101", "taxa": []}
{"type": "biolink:Cell", "ic": 73.73386095387401, "identifiers": [{"i": "CL:0002067", "l": "type A enteroendocrine cell", "d": ["An enteroendocrine cell that produces glucagon."], "t": []}, {"i": "UMLS:C2326580", "l": "Type A enteroendocrine cell", "d": [], "t": []}], "preferred_name": "type A enteroendocrine cell", "taxa": []}
{"type": "biolink:Cell", "ic": 74.50942324134168, "identifiers": [{"i": "UMLS:C1708918", "l": "Malignant Squamoid Cell", "d": [], "t": []}, {"i": "NCIT:C47808", "l": "Malignant Squamoid Cell", "d": [], "t": []}], "preferred_name": "Malignant Squamoid Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1514176", "l": "Pleomorphic Meningothelial Cell", "d": [], "t": []}, {"i": "NCIT:C37158", "l": "Pleomorphic Meningothelial Cell", "d": [], "t": []}], "preferred_name": "Pleomorphic Meningothelial Cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1955385", "l": "Spermatozoa.short tail", "d": [], "t": []}], "preferred_name": "Spermatozoa.short tail", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4042012", "l": "L2 marginal neuron", "d": ["An L2 intratelencephalic projecting glutamatergic neuron with a soma on the L1-L2 border. This neuron type has small apical dendrites projecting to L1."], "t": []}], "preferred_name": "L2 marginal neuron", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5781226", "l": "Autologous CAR T Cells U87", "d": [], "t": []}, {"i": "NCIT:C192817", "l": "Autologous CAR T Cells U87", "d": ["A preparation of autologous T-lymphocytes that have been genetically modified to express a chimeric antigen receptor (CAR) specific for an as of yet undisclosed tumor-associated antigen (TAA), with potential immunostimulating and antineoplastic activities. Upon administration, autologous CAR T cells U87 specifically targets and binds to tumor cells that express the undisclosed TAA, resulting in tumor cell lysis."], "t": []}], "preferred_name": "Autologous CAR T Cells U87", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1440361", "l": "CD83+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:1372937001", "l": "", "d": [], "t": []}], "preferred_name": "CD83+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0596698", "l": "heterokaryon", "d": [], "t": []}], "preferred_name": "heterokaryon", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1512132", "l": "ES03", "d": [], "t": []}, {"i": "NCIT:C20251", "l": "ES03", "d": ["Provider: ES Cell International Pte Ltd., Melbourne, Australia. Information from provider and not independently verified by NIH: Cells are positive for cell markers Oct-4, SSEA-4, TRA-1-60, GCTM-2, and alkaline phosphatase activity; Cells are negative for cell marker SSEA-1; Give rise to teratomas containing derivatives of three germ layers in SCID mice; Differentiate in vitro into extraembryonic and somatic cell lineages; Neural progenitor cells may be isolated from differentiating ES cell cultures and induced to form mature neurons; Available for distribution. This cell line meets the criteria for the use of human embryonic stem cells by federally funded researchers."], "t": []}], "preferred_name": "ES03", "taxa": []}
{"type": "biolink:Cell", "ic": 90.871710685482, "identifiers": [{"i": "UMLS:C1518858", "l": "Pale Brown Fat Cell", "d": [], "t": []}, {"i": "NCIT:C36970", "l": "Pale Brown Fat Cell", "d": [], "t": []}], "preferred_name": "Pale Brown Fat Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0000938", "l": "CD16-negative, CD56-bright natural killer cell, human", "d": ["NK cell that has the phenotype CD56-bright, CD16-negative, and CD84-positive with the function to secrete interferon-gamma but is not cytotoxic."], "t": []}], "preferred_name": "CD16-negative, CD56-bright natural killer cell, human", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5157483", "l": "CD33 blasts | Blood | Cell markers", "d": [], "t": []}], "preferred_name": "CD33 blasts | Blood | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": 54.776662757870994, "identifiers": [{"i": "UMLS:C1518068", "l": "Lymphocyte Predominant Cell", "d": [], "t": []}, {"i": "NCIT:C37027", "l": "Lymphocyte Predominant Cell", "d": [], "t": []}], "preferred_name": "Lymphocyte Predominant Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 84.21065366064373, "identifiers": [{"i": "UMLS:C0022687", "l": "Lymphokine-Activated Killer Cells", "d": [], "t": []}, {"i": "NCIT:C13008", "l": "Lymphokine-Activated Killer Cells", "d": ["Killer cell lymphocytes activated in the presence of interleukin-2 (IL-2).  Lymphokine-activated killer cells (LAKs) are cytotoxic effector cells with an exceptionally wide target cell spectrum including normal and malignant cells of different origins.  LAK cells exhibit a profound heterogeneity with regard to phenotype surface marker expression; it remains to be determined if they represent a unique cell lineage."], "t": []}, {"i": "MESH:D015979", "l": "Killer Cells, Lymphokine-Activated", "d": [], "t": []}], "preferred_name": "Lymphokine-Activated Killer Cells", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "CL:4047019", "l": "early enterocyte", "d": ["An enterocyte in the early stages of development, located above the transit-amplifying cell zone in the intestinal crypt-villus axis."], "t": []}], "preferred_name": "early enterocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 67.84836621650341, "identifiers": [{"i": "CL:0002194", "l": "monopoietic cell", "d": ["A cell involved in the formation of a monocyte (monopoiesis)."], "t": []}, {"i": "UMLS:C2326252", "l": "Monopoietic cell", "d": [], "t": []}], "preferred_name": "monopoietic cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1515313", "l": "Mouse Testicular Interstitial Cell", "d": [], "t": []}, {"i": "NCIT:C22180", "l": "Mouse Testicular Interstitial Cell", "d": [], "t": []}], "preferred_name": "Mouse Testicular Interstitial Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4307134", "l": "BAM NN_1 Fos border associated macrophage (Mmus)", "d": ["A border associated macrophage of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Mrc1 (Mmus), Pf4 (Mmus), Fos (Mmus). It is distinguished from other BAM NN cells by expression of Fos. These cells are located in the Isocortex, Cerebellum, brain . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5314 BAM NN_1."], "t": []}], "preferred_name": "BAM NN_1 Fos border associated macrophage (Mmus)", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1267881", "l": "Lymphocyte negative for CD16 antigen and positive for CD34 antigen", "d": [], "t": []}, {"i": "SNOMEDCT:117558000", "l": "", "d": [], "t": []}], "preferred_name": "Lymphocyte negative for CD16 antigen and positive for CD34 antigen", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5555040", "l": "Autologous Neoantigen-specific T-lymphocytes GEN-011", "d": [], "t": []}, {"i": "NCIT:C178447", "l": "Autologous Neoantigen-specific T-lymphocytes GEN-011", "d": ["A preparation of autologous, personalized, immunogenic and tumor neoantigen-specific T-lymphocytes, with potential immunostimulating and antineoplastic activities. Tumor-specific neoantigen targets of autologous CD4+ and/or CD8+ T-cells are identified and T-cells that target immunogenic and stimulatory neoantigens are expanded ex vivo. Upon administration, the autologous neoantigen-specific T-lymphocytes GEN-011 recognize and bind to tumor cells expressing the targeted neoantigens, resulting in a cytotoxic T-lymphocyte (CTL)-mediated immune response against the patient's tumor cells."], "t": []}], "preferred_name": "Autologous Neoantigen-specific T-lymphocytes GEN-011", "taxa": []}
{"type": "biolink:Cell", "ic": 57.19116033752107, "identifiers": [{"i": "CL:0000051", "l": "common lymphoid progenitor", "d": ["A oligopotent progenitor cell committed to the lymphoid lineage."], "t": []}], "preferred_name": "common lymphoid progenitor", "taxa": []}
{"type": "biolink:Cell", "ic": 77.60424150429895, "identifiers": [{"i": "UMLS:C1514096", "l": "Neoplastic Small to Medium-Sized T-Lymphocyte", "d": [], "t": []}, {"i": "NCIT:C39606", "l": "Neoplastic Small to Medium-Sized T-Lymphocyte", "d": [], "t": []}], "preferred_name": "Neoplastic Small to Medium-Sized T-Lymphocyte", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1717666", "l": "CD4+CD45RA+CD45RB+CD45RC+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:1373278004", "l": "", "d": [], "t": []}], "preferred_name": "CD4+CD45RA+CD45RB+CD45RC+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5960126", "l": "Remvulimorgene Autoleucel", "d": [], "t": []}, {"i": "NCIT:C206977", "l": "Remvulimorgene Autoleucel", "d": [], "t": []}], "preferred_name": "Remvulimorgene Autoleucel", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5417988", "l": "Autologous Tumor Infiltrating Lymphocytes LN-145-S1", "d": [], "t": []}, {"i": "NCIT:C173508", "l": "Autologous Tumor Infiltrating Lymphocytes LN-145-S1", "d": ["A proprietary preparation of autologous tumor infiltrating lymphocytes (TILs), with potential immunomodulating and antineoplastic activities. The autologous TILs are isolated from an autologous tumor sample and expanded ex vivo in the presence of interleukin-2 (IL-2). Upon infusion of the autologous TILs LN-145-S1 back into the patient, the cells specifically recognize, target and kill the patient's tumor cells."], "t": []}], "preferred_name": "Autologous Tumor Infiltrating Lymphocytes LN-145-S1", "taxa": []}
{"type": "biolink:Cell", "ic": 90.871710685482, "identifiers": [{"i": "UMLS:C1514274", "l": "Postgerminal Center Memory B-Lymphocyte", "d": [], "t": []}, {"i": "NCIT:C38339", "l": "Postgerminal Center Memory B-Lymphocyte", "d": [], "t": []}], "preferred_name": "Postgerminal Center Memory B-Lymphocyte", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5157468", "l": "CD3+HLA-DR+ cells | Cerebral spinal fluid | Cell markers", "d": [], "t": []}], "preferred_name": "CD3+HLA-DR+ cells | Cerebral spinal fluid | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4042014", "l": "spiny VIP neuron", "d": ["A VIP GABAergic cortical interneuron with a soma located in L1-3 of some neocortex in Mmus. This neuron has a multipolar morphology with spiny dendrites concentrating on L1 of the cortex, and has a burst firing electrophysiological signature with highly dynamic dendritic spines."], "t": []}], "preferred_name": "spiny VIP neuron", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C2340535", "l": "Spiny stellate cell of cerebral cortex", "d": [], "t": []}], "preferred_name": "Spiny stellate cell of cerebral cortex", "taxa": []}
{"type": "biolink:Cell", "ic": 59.585099777811166, "identifiers": [{"i": "CL:0000076", "l": "squamous epithelial cell", "d": ["An epithelial cell that has a flattened morphology."], "t": []}], "preferred_name": "squamous epithelial cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5177340", "l": "Pincer cells | Blood | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Pincer cells | Blood | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:7770002", "l": "juxtacanalicular tissue cell", "d": ["A trabecular meshwork cell of the juxtacanalicular tissue (JCT), characterized by a spindle-shaped, fibroblast-like morphology within a loose extracellular matrix immediately adjacent to Schlemm's canal. It expresses CHI3L1 (human and mouse) and ANGPTL7 (human), as well as smooth muscle actin for contractility. Unlike other trabecular meshwork cells, it does not form monolayers but exists in a loose network, regulating aqueous humor outflow resistance through continuous ECM remodelling, mechanotransduction, and formation of intracellular pores historically called giant vacuoles."], "t": []}], "preferred_name": "juxtacanalicular tissue cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5855623", "l": "Allogeneic Gene-modified Gamma Delta T-cells", "d": [], "t": []}, {"i": "NCIT:C199489", "l": "Allogeneic Gene-modified Gamma Delta T-cells", "d": ["A preparation of genetically modified allogeneic gamma delta T-lymphocytes, with potential immunomodulating and antineoplastic activities. Upon administration, the allogeneic gene-modified gamma delta T-cells secrete interferon-gamma (IFN-g) and exert direct killing of tumor cells. In addition, these cells activate the immune system to exert a cytotoxic T-lymphocyte (CTL) response against tumor cells. Gamma delta T-lymphocytes play a key role in the activation of the immune system and do not require major histocompatibility complex (MHC)-mediated antigen presentation to exert their cytotoxic effect. The genetic modification of the allogeneic gene-modified gamma delta T-cells may confer resistance to alkylating chemotherapeutic agents including temozolomide and allow the use of the gamma delta T-cells as an adjunct to these agents."], "t": []}], "preferred_name": "Allogeneic Gene-modified Gamma Delta T-cells", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5854551", "l": "Allogeneic CAR T Cells CT0594CP", "d": [], "t": []}, {"i": "NCIT:C200542", "l": "Allogeneic CAR T Cells CT0594CP", "d": ["A preparation of allogeneic T-lymphocytes that have been genetically modified to express chimeric antigen receptors (CARs) specific for as of yet undisclosed tumor-associated antigens (TAAs), with potential immunostimulating and antineoplastic activities. Upon administration, allogeneic CAR T cells CT0594CP specifically targets and binds to tumor cells that express the undisclosed TAAs, resulting in tumor cell lysis."], "t": []}], "preferred_name": "Allogeneic CAR T Cells CT0594CP", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1977364", "l": "Granulocytes.CD55", "d": [], "t": []}], "preferred_name": "Granulocytes.CD55", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0229649", "l": "Heterophil", "d": [], "t": []}, {"i": "SNOMEDCT:76335007", "l": "", "d": [], "t": []}], "preferred_name": "Heterophil", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5170926", "l": "Leukocytes | Dialysis fluid | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Leukocytes | Dialysis fluid | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": 92.76600187037766, "identifiers": [{"i": "CL:0002384", "l": "uninucleate macroconidium", "d": ["A macroconidium that has only one nucleus."], "t": []}], "preferred_name": "uninucleate macroconidium", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1268003", "l": "Lymphocyte positive for CD198 antigen", "d": [], "t": []}, {"i": "SNOMEDCT:117443006", "l": "", "d": [], "t": []}], "preferred_name": "Lymphocyte positive for CD198 antigen", "taxa": []}
{"type": "biolink:Cell", "ic": 88.20185721311867, "identifiers": [{"i": "UMLS:C5703073", "l": "anti-CD5 CAR T cells", "d": [], "t": []}, {"i": "NCIT:C211937", "l": "Anti-CD5 CAR T Cells Preparation", "d": ["Any preparation of chimeric antigen receptor (CAR) expressing T-lymphocytes that targets the tumor-associated antigen (TAA) CD5."], "t": []}], "preferred_name": "anti-CD5 CAR T cells", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5855288", "l": "Durcabtagene Autoleucel", "d": [], "t": []}, {"i": "NCIT:C199006", "l": "Durcabtagene Autoleucel", "d": [], "t": []}], "preferred_name": "Durcabtagene Autoleucel", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "CL:0000516", "l": "perineuronal satellite cell", "d": ["A non-neuronal cell that surrounds the neuronal cell bodies of the ganglia."], "t": []}, {"i": "UMLS:C0205868", "l": "Perineuronal satellite cell", "d": [], "t": []}, {"i": "NCIT:C12619", "l": "Perineuronal Satellite Cell", "d": ["A flattened non-neuronal cell surrounding a ganglion cell."], "t": []}, {"i": "NCIT:C33516", "l": "Satellite Cell", "d": ["An elongated cell that is closely associated with a muscle fiber; it either is flattened against the fiber or occupies shallow depressions in its surface."], "t": []}, {"i": "MESH:D027161", "l": "Satellite Cells, Perineuronal", "d": [], "t": []}, {"i": "SNOMEDCT:28922004", "l": "", "d": [], "t": []}], "preferred_name": "perineuronal satellite cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1510985", "l": "Autologous Tumor Cell", "d": [], "t": []}, {"i": "NCIT:C12940", "l": "Autologous Tumor Cell", "d": [], "t": []}], "preferred_name": "Autologous Tumor Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4033106", "l": "superior cervical ganglion VIP neuron", "d": ["A sympathetic neuron that has the soma located in the superior cervical ganglion and expresses the marker vasoactive intestinal peptide (VIP)."], "t": []}], "preferred_name": "superior cervical ganglion VIP neuron", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "CL:0002561", "l": "outer root sheath cell", "d": ["An epithelial cell that is part of the outer root sheath."], "t": []}], "preferred_name": "outer root sheath cell", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "UMLS:C0879357", "l": "Vaccine-Sensitized Draining Lymph Node Cells", "d": [], "t": []}, {"i": "NCIT:C2542", "l": "Vaccine-Sensitized Draining Lymph Node Cells", "d": ["Cells isolated from lymph nodes from patients, and activated in vitro to generate tumor-specific effector T cells.  Lymph nodes in the lymphatics draining tumors often contain T cells that are immunologically sensitized but functionally deficient. Vaccine-sensitized draining lymph node cells are prepared by isolating these lymphocytes in vitro and stimulating them with cytokines to differentiate into mature effector cells.  Vaccine-draining lymph node cells may also be produced by pharmacological activation of lymph node-derived lymphocytes with drugs such as ionomycin or with bacterial toxin; these activated lymphocytes may be expanded in culture with cytokines such as interleukin-2 prior to infusion into the patient. (NCI04)"], "t": []}], "preferred_name": "Vaccine-Sensitized Draining Lymph Node Cells", "taxa": []}
{"type": "biolink:Cell", "ic": 87.18682603146104, "identifiers": [{"i": "UMLS:C1882056", "l": "Neoplastic Leutein Cell", "d": [], "t": []}, {"i": "NCIT:C61430", "l": "Neoplastic Leutein Cell", "d": [], "t": []}], "preferred_name": "Neoplastic Leutein Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 73.613037951824, "identifiers": [{"i": "CL:0000787", "l": "memory B cell", "d": ["A memory B cell is a mature B cell that is long-lived, readily activated upon re-encounter of its antigenic determinant, and has been selected for expression of higher affinity immunoglobulin. This cell type has the phenotype CD19-positive, CD20-positive, MHC Class II-positive, and CD138-negative."], "t": []}, {"i": "UMLS:C0682638", "l": "Memory B Cells", "d": [], "t": []}, {"i": "NCIT:C13123", "l": "Memory B-Lymphocyte", "d": ["A subset of mature B-lymphocytes that are formed during primary antigen exposure, survive for many years after the infection has resolved and maintain specificity toward the primary antigen. These cells can quickly produce a large amount of antigen-specific antibodies in response to a subsequent exposure."], "t": []}, {"i": "MESH:D000091245", "l": "Memory B Cells", "d": [], "t": []}], "preferred_name": "memory B cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C3642444", "l": "CD19CAR-CD3zeta-expressing Autologous T lymphocytes", "d": [], "t": []}, {"i": "NCIT:C88266", "l": "CD19CAR-CD3zeta-expressing Autologous T lymphocytes", "d": ["Autologous T-lymphocytes transduced with a modified lentiviral vector expressing a chimeric antigen receptor (CAR) consisting of an anti-CD19 scFv (single chain variable fragment) and the zeta chain of the TCR/CD3 complex (CD3-zeta), with potential immunomodulating and antineoplastic activities. Upon transfusion, CD19CAR-CD3zeta-expressing autologous T-lymphocytes are directed to CD19-expressing tumor cells, thereby inducing a selective toxicity only in these tumor cells. The CD19 antigen is a B-cell specific cell surface antigen expressed in all B-cell lineage malignancies. CD3-zeta (or CD247) is a transmembrane signaling adaptor polypeptide that regulates the assembly of complete T-cell receptor complexes and their expression on the cell surface."], "t": []}], "preferred_name": "CD19CAR-CD3zeta-expressing Autologous T lymphocytes", "taxa": []}
{"type": "biolink:Cell", "ic": 62.530867282247726, "identifiers": [{"i": "UMLS:C1512642", "l": "Immature T-Lymphocyte", "d": [], "t": []}, {"i": "NCIT:C38325", "l": "Immature T-Lymphocyte", "d": ["A cell developed in the thymus that differentiates into a mature T-lymphocyte. The maturation is dependent on several transcription factors including GATA-3 and c-Myb. The expression of the pre-T cell receptor alpha (pTa) gene occurs exclusively in the immature T lymphocyte."], "t": []}], "preferred_name": "Immature T-Lymphocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:1000391", "l": "melanocyte of eyelid", "d": ["A melanocyte that is part of the eyelid."], "t": []}, {"i": "UMLS:C2325209", "l": "Melanocyte of eyelid", "d": [], "t": []}], "preferred_name": "melanocyte of eyelid", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0882793", "l": "CD14+CD16+CD59+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:1373086008", "l": "", "d": [], "t": []}], "preferred_name": "CD14+CD16+CD59+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0019020", "l": "extrahepatic cholangiocyte", "d": ["An epithelial cell of the extrahepatic bile ducts, including the left and right hepatic duct, common hepatic duct, and common bile duct. They are columnar in shape, and have a large nuclear-to-cytoplasmic ratio relative to small/intrahepatic cholangiocytes."], "t": []}], "preferred_name": "extrahepatic cholangiocyte", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1440404", "l": "Cells.t(12;21)(p13;q22.3)(ETV6,RUNX1)", "d": [], "t": []}], "preferred_name": "Cells.t(12;21)(p13;q22.3)(ETV6,RUNX1)", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:1000310", "l": "adipocyte of epicardial fat of right ventricle", "d": ["An adipocyte that is part of the epicardial fat of right ventricle."], "t": []}, {"i": "UMLS:C2333515", "l": "Adipocyte of epicardial fat of right ventricle", "d": [], "t": []}], "preferred_name": "adipocyte of epicardial fat of right ventricle", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0011106", "l": "GABAnergic interplexiform cell", "d": ["A type of interneuron in the retinal inner nuclear layer which\ncarries information from the inner plexiform layer and the outer\nplexiform layer using GABA."], "t": []}], "preferred_name": "GABAnergic interplexiform cell", "taxa": []}
{"type": "biolink:Cell", "ic": 64.3075719698835, "identifiers": [{"i": "UMLS:C1709175", "l": "Neoplastic Fibroblast", "d": [], "t": []}, {"i": "NCIT:C48682", "l": "Neoplastic Fibroblast", "d": [], "t": []}], "preferred_name": "Neoplastic Fibroblast", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5703312", "l": "Anti-Immunoglobulin-beta CAR T Cells", "d": [], "t": []}, {"i": "NCIT:C187298", "l": "Anti-Immunoglobulin-beta CAR T Cells", "d": ["A preparation of T-lymphocytes that are genetically engineered to express a chimeric antigen receptor (CAR) targeting immunoglobulin-beta (Igb), with potential immunostimulating and antineoplastic activities. Upon administration, the anti-Igb CAR T cells are directed to, specifically bind to, and induce selective toxicity in Igb antigen-expressing tumor cells."], "t": []}], "preferred_name": "Anti-Immunoglobulin-beta CAR T Cells", "taxa": []}
{"type": "biolink:Cell", "ic": 73.85694246010084, "identifiers": [{"i": "UMLS:C2699839", "l": "EBV-Transformed Mature B-Lymphocyte", "d": [], "t": []}, {"i": "NCIT:C80283", "l": "EBV-Transformed Mature B-Lymphocyte", "d": [], "t": []}], "preferred_name": "EBV-Transformed Mature B-Lymphocyte", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4695998", "l": "CD3+CD8+CD27-CD45RO+CD62L- cell", "d": [], "t": []}, {"i": "SNOMEDCT:1373270006", "l": "", "d": [], "t": []}], "preferred_name": "CD3+CD8+CD27-CD45RO+CD62L- cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1267841", "l": "Lymphocyte positive for both CD4 antigen and 2H4 antigen", "d": [], "t": []}, {"i": "SNOMEDCT:117528006", "l": "", "d": [], "t": []}], "preferred_name": "Lymphocyte positive for both CD4 antigen and 2H4 antigen", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1440380", "l": "Cells.cyclin D1", "d": [], "t": []}], "preferred_name": "Cells.cyclin D1", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4033160", "l": "myenteric ganglion of small intestine ChAT neuron", "d": ["An enteric neuron that has the soma located in the myenteric ganglion of the small intestine and expresses the marker choline O-acetyltransferase (ChAT)."], "t": []}], "preferred_name": "myenteric ganglion of small intestine ChAT neuron", "taxa": []}
{"type": "biolink:Cell", "ic": 84.83823963392128, "identifiers": [{"i": "CL:0000437", "l": "gonadtroph", "d": ["A rounded cell that is usually situated next to sinusoids; secretes follicular stimulating hormone (FSH) and luteinizing hormone (LH)."], "t": []}, {"i": "UMLS:C1708248", "l": "Gonadotrophs", "d": [], "t": []}, {"i": "NCIT:C32691", "l": "Gonadotroph Cell", "d": ["An endocrine cell of the adenohypophysis that affects certain cells of the ovary or testis."], "t": []}, {"i": "MESH:D052681", "l": "Gonadotrophs", "d": [], "t": []}, {"i": "SNOMEDCT:44490009", "l": "", "d": [], "t": []}], "preferred_name": "gonadtroph", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "UMLS:C1517732", "l": "Large Keratinocyte", "d": [], "t": []}, {"i": "NCIT:C36750", "l": "Large Keratinocyte", "d": [], "t": []}], "preferred_name": "Large Keratinocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5666893", "l": "Autologous Anti-CD19 CAR-expressing T-lymphocytes IC19/1563", "d": [], "t": []}, {"i": "NCIT:C182623", "l": "Autologous Anti-CD19 CAR-expressing T-lymphocytes IC19/1563", "d": ["preparation of autologous T-lymphocytes that have been genetically modified to express a chimeric antigen receptor (CAR) that targets the human tumor associated antigen (TAA) CD19, with potential immunostimulating and antineoplastic activities. Upon administration, autologous anti-CD19 CAR-expressing T-lymphocytes IC19/1563 bind to and induce selective toxicity against CD19-expressing tumor cells. The CD19 antigen is a B-cell-specific cell surface antigen expressed in all B-cell lineage malignancies."], "t": []}], "preferred_name": "Autologous Anti-CD19 CAR-expressing T-lymphocytes IC19/1563", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5446552", "l": "GC012F", "d": [], "t": []}, {"i": "NCIT:C175471", "l": "Autologous Bispecific BCMA/CD19-targeted CAR-T Cells GC012F", "d": ["A preparation of autologous T-lymphocytes engineered to express two separate chimeric antigen receptors (CARs) targeting the tumor-associated antigens (TAAs) BCMA and CD19 and fused to as of yet not fully elucidated co-stimulatory domains, with potential immunostimulating and antineoplastic activities. Upon administration, the autologous bispecific BCMA/CD19-targeted CAR-T cells GC012F specifically and simultaneously target and bind to tumor cells expressing BCMA and/or CD19. This induces selective toxicity in tumor cells that express BCMA and/or CD19. BCMA, a tumor-specific antigen and a receptor for both a proliferation-inducing ligand (APRIL) and B-cell activating factor (BAFF), is a member of the tumor necrosis factor receptor superfamily (TNFRSF) and plays a key role in the survival of B-lymphocytes and plasma cells. BCMA is found on the surfaces of B-cells and is overexpressed on malignant plasma cells. CD19 is a B-cell-specific cell surface antigen overexpressed in B-cell lineage malignancies. The processing platform used, FasT CAR-T, shortens the manufacturing time to produce the CAR-T cells within 24 hours."], "t": []}], "preferred_name": "GC012F", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0521183", "l": "Buhot cell", "d": [], "t": []}, {"i": "SNOMEDCT:30469008", "l": "", "d": [], "t": []}], "preferred_name": "Buhot cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0008006", "l": "muscle founder cell", "d": ["A myoblast that detemines the properties (size, shape and attachment to the epidermis) of a `somatic muscle myotube` (CL:0008003) .  It develops into a somatic muscle myotube via fusion with `fusion component myoblasts` (CL:0000621)."], "t": []}], "preferred_name": "muscle founder cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:2000047", "l": "brainstem motor neuron", "d": ["Any motor neuron that is part of a brainstem."], "t": []}], "preferred_name": "brainstem motor neuron", "taxa": []}
{"type": "biolink:Cell", "ic": 88.20185721311867, "identifiers": [{"i": "CL:4030002", "l": "effector memory CD45RA-positive, alpha-beta T cell, terminally differentiated", "d": ["An alpha-beta memory T cell with the phenotype CD45RA-positive."], "t": []}], "preferred_name": "effector memory CD45RA-positive, alpha-beta T cell, terminally differentiated", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:1000277", "l": "smooth muscle fiber of jejunum", "d": ["A smooth muscle cell that is part of the jejunum."], "t": []}, {"i": "UMLS:C0734269", "l": "Smooth muscle fiber of jejunum", "d": [], "t": []}], "preferred_name": "smooth muscle fiber of jejunum", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5667009", "l": "NIB 103", "d": [], "t": []}], "preferred_name": "NIB 103", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C2953492", "l": "Set of neural cells", "d": [], "t": []}], "preferred_name": "Set of neural cells", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5395464", "l": "Autologous cultured chondrocyte-containing product in parenteral dose form", "d": [], "t": []}, {"i": "SNOMEDCT:840616008", "l": "", "d": [], "t": []}], "preferred_name": "Autologous cultured chondrocyte-containing product in parenteral dose form", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5183793", "l": "Transitional cells | Urine sediment | Urinalysis", "d": [], "t": []}], "preferred_name": "Transitional cells | Urine sediment | Urinalysis", "taxa": []}
{"type": "biolink:Cell", "ic": 79.64650900338474, "identifiers": [{"i": "CL:4023039", "l": "amygdala excitatory neuron", "d": ["Any neuron that has its soma located in some amygdala and is capable of some glutamate secretion, neurotransmission."], "t": []}], "preferred_name": "amygdala excitatory neuron", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1517818", "l": "Mouse Pre-T-Lymphocyte", "d": [], "t": []}, {"i": "NCIT:C22580", "l": "Mouse Pre-T-Lymphocyte", "d": [], "t": []}], "preferred_name": "Mouse Pre-T-Lymphocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4033147", "l": "vestibular ganglion SP neuron", "d": ["A sensory neuron that has the soma located in the vestibular ganglion and expresses the marker substance P (SP)."], "t": []}], "preferred_name": "vestibular ganglion SP neuron", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4042037", "l": "sst GABAergic neuron of the striatum", "d": ["A interneuron of the striatum expressing gamma-aminobutyric acid and somatostatin. This interneuron has a fusiform soma with a diameter between 9 - 25 µm, it has a long axon up to the length of 1mm. This neuron type displays a low threshold Ca2+ spike (LTS), a high input resistance, and the expression of long-lasting plateau potentials following depolarization from rest."], "t": []}], "preferred_name": "sst GABAergic neuron of the striatum", "taxa": []}
{"type": "biolink:Cell", "ic": 42.95458191188551, "identifiers": [{"i": "UMLS:C1709186", "l": "Neoplastic Mononuclear Stromal Cell", "d": [], "t": []}, {"i": "NCIT:C49055", "l": "Neoplastic Mononuclear Stromal Cell", "d": [], "t": []}], "preferred_name": "Neoplastic Mononuclear Stromal Cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5157420", "l": "CD3 blasts | Blood | Cell markers", "d": [], "t": []}], "preferred_name": "CD3 blasts | Blood | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5856187", "l": "Autologous Anti-CD1a CAR T Cells", "d": [], "t": []}, {"i": "NCIT:C200257", "l": "Autologous Anti-CD1a CAR T Cells", "d": ["A preparation of autologous T-lymphocytes that have been genetically modified to express a chimeric antigen receptor (CAR) specific for the T-cell surface glycoprotein CD1a, with potential immunostimulating and antineoplastic activities. Upon administration, autologous anti-CD1a CAR T cells bind to and induce selective toxicity in CD1a-expressing tumor cells. CD1a, an antigen-presenting glycoprotein, is exclusively expressed in cortical T-cell acute lymphoblastic leukemia (T-ALL) and otherwise only normally expressed in developing cortical thymocytes and Langerhans cells."], "t": []}], "preferred_name": "Autologous Anti-CD1a CAR T Cells", "taxa": []}
{"type": "biolink:Cell", "ic": 92.76600187037766, "identifiers": [{"i": "CL:0002114", "l": "CD38-positive unswitched memory B cell", "d": ["A CD38-positive unswitched memory B cell is an unswitched memory B cell that has the phenotype CD38-positive, IgD-positive, CD138-negative, and IgG-negative."], "t": []}], "preferred_name": "CD38-positive unswitched memory B cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0002107", "l": "IgD-negative CD38-positive IgG memory B cell", "d": ["An IgD-negative CD38-positive IgG memory B cell is a CD38-positive IgG-positive that has class switched and lacks expression of IgD on the cell surface with the phenotype IgD-negative, CD38-positive, and IgG-positive."], "t": []}], "preferred_name": "IgD-negative CD38-positive IgG memory B cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C4763774", "l": "Autologous Anti-CD19CAR-CD28tm/4-1BB/CD3zeta-HER2tG-expressing CD4+/CD8+ T-lymphocytes SCRI-huCAR19v1", "d": [], "t": []}, {"i": "NCIT:C157655", "l": "Autologous Anti-CD19CAR-CD28tm/4-1BB/CD3zeta-HER2tG-expressing CD4+/CD8+ T-lymphocytes SCRI-huCAR19v1", "d": ["A preparation of autologous CD4- and CD8-positive T-lymphocytes that have been transduced with a third-generation self-inactivating (SIN) lentiviral vector (LV) expressing a human-derived immunoglobulin G4 (IgG4) hinge-optimized chimeric antigen receptor (CAR) consisting of a single chain variable fragment (scFv) specific for CD19 that is fused to a human CD28 transmembrane domain (CD28tm), the intracellular cytoplasmic domain of 4-1BB (CD137) and the zeta chain of the TCR/CD3 complex (CD3zeta), and linked to a truncated form of the human epidermal growth factor receptor 2 (HER2tG), with potential immunostimulating and antineoplastic activities. Upon administration, the autologous CD4+/CD8+ T-lymphocytes SCRI-huCAR19v1 specifically target and bind to CD19-expressing neoplastic B-cells. This results in a cytotoxic T-lymphocyte (CTL) response against CD19-expressing tumor cells and causes tumor cell lysis. CD19 is a B-cell-specific cell surface antigen that is overexpressed in B-cell lineage tumors. Incorporation of the costimulatory signaling domains of CD28 and 4-1BB increases human T-cell function, expansion, and survival. Devoid of both ligand binding domains and tyrosine kinase activity, the co-expressed HER2tG both facilitates in vivo detection of the administered, transduced T-cells and can promote elimination of those cells through a trastuzumab-induced antibody dependent cellular cytotoxicity (ADCC) response."], "t": []}], "preferred_name": "Autologous Anti-CD19CAR-CD28tm/4-1BB/CD3zeta-HER2tG-expressing CD4+/CD8+ T-lymphocytes SCRI-huCAR19v1", "taxa": []}
{"type": "biolink:Cell", "ic": 70.59347386640042, "identifiers": [{"i": "CL:0000196", "l": "insect flight muscle cell", "d": ["A muscle cell that is involved in the mechanism of insect flight. This encompasses both, cells that power flight and cells that control flight."], "t": []}], "preferred_name": "insect flight muscle cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:1000596", "l": "inner renal cortex cell", "d": ["Any kidney cell that is part of some juxtamedullary cortex."], "t": []}], "preferred_name": "inner renal cortex cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C4763382", "l": "Autologous Anti-NY-ESO-1/LAGE-1 TCR-transduced c259 T Lymphocytes GSK3377794", "d": [], "t": []}, {"i": "NCIT:C121379", "l": "Letetresgene Autoleucel", "d": ["Human autologous T-lymphocytes transduced with a lentiviral vector encoding a T-cell receptor (TCR) specific for the cancer-testis antigens (CTAs) NY-ESO-1 and L antigen family member 1 (LAGE-1; Cancer/Testis Antigen 2; CTAG2; CT2), with potential antineoplastic activity. Following leukapheresis, isolation of lymphocytes, expansion ex vivo, transduction, and reintroduction into the patient, letetresgene autoleucel specifically target and bind to NY-ESO-1/LAGE-1-overexpressing tumor cells. This may result in a cytotoxic T-lymphocyte (CTL)-mediated elimination of NY-ESO-1/LAGE-1-positive cancer cells. NY-ESO-1 and LAGE-1, members of the cancer-testis antigen (CTA) family, are overexpressed on the surface of various tumor cell types."], "t": []}], "preferred_name": "Autologous Anti-NY-ESO-1/LAGE-1 TCR-transduced c259 T Lymphocytes GSK3377794", "taxa": []}
{"type": "biolink:Cell", "ic": 92.76600187037766, "identifiers": [{"i": "CL:0020047", "l": "interneuron of myenteric plexus", "d": ["An interneuron of the enteric nervous system whose soma resides in the myenteric plexus. Interneurons of the myenteric plexus integrate sensory input from intrinsic primary afferent neurons (IPANs) and modulate motor output to smooth muscle and secretory epithelia by synapsing onto motor neurons and other interneurons within the plexus."], "t": []}], "preferred_name": "interneuron of myenteric plexus", "taxa": []}
{"type": "biolink:Cell", "ic": 92.76600187037766, "identifiers": [{"i": "UMLS:C1881549", "l": "Malignant Epithelial Large Polygonal Cell", "d": [], "t": []}, {"i": "NCIT:C61001", "l": "Malignant Epithelial Large Polygonal Cell", "d": [], "t": []}], "preferred_name": "Malignant Epithelial Large Polygonal Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1518219", "l": "Malignant Neuroendocrine Fusiform Small Cell", "d": [], "t": []}, {"i": "NCIT:C36720", "l": "Malignant Neuroendocrine Fusiform Small Cell", "d": [], "t": []}], "preferred_name": "Malignant Neuroendocrine Fusiform Small Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 71.06400748151069, "identifiers": [{"i": "CL:0008026", "l": "open tracheal system tracheocyte", "d": ["An epithelial cell that is part of the epithelium of a tracheal tube in an open tracheal system, such as that found in insects."], "t": []}], "preferred_name": "open tracheal system tracheocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 76.04769967783396, "identifiers": [{"i": "CL:0000129", "l": "microglial cell", "d": ["A transcriptomically distinct central nervous system macrophage found in the parenchyma of the central nervous system. Marker include CD11b-positive, F4/80-positive, and CD68-positive."], "t": []}, {"i": "UMLS:C0206116", "l": "Microglia", "d": [], "t": []}, {"i": "NCIT:C12616", "l": "Microglia", "d": ["A type of glial cell that mediates immune responses by clearing cellular debris and dead neurons from nervous tissue through phagocytosis."], "t": []}, {"i": "MESH:D017628", "l": "Microglia", "d": [], "t": []}, {"i": "SNOMEDCT:63483002", "l": "", "d": [], "t": []}], "preferred_name": "microglial cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5157318", "l": "CD15 blasts | Bone marrow | Cell markers", "d": [], "t": []}], "preferred_name": "CD15 blasts | Bone marrow | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C4287777", "l": "PRAME-targeting T-cell Receptor/Inducible Caspase 9 BPX-701", "d": [], "t": []}, {"i": "NCIT:C128029", "l": "PRAME-targeting T-cell Receptor/Inducible Caspase 9 BPX-701", "d": ["Human allogeneic T-lymphocytes transduced with a retroviral vector encoding a high-affinity T-cell receptor (TCR) specific for human leukocyte antigen (HLA)-A2-01-restricted, preferentially-expressed antigen in melanoma (PRAME) and containing the chemical induction of dimerization (CID) suicide/safety switch, composed of a drug binding domain coupled to the signaling domain of the suicide enzyme caspase-9, with potential antineoplastic activity. Peripheral blood mononuclear cells (PBMCs) are isolated from a patient, transduced with an anti-PRAME-HLA-A2 restricted TCR, expanded ex vivo, and reintroduced into the HLA-A2-positive patient. Upon reintroduction, PRAME-targeting T-cell receptor-based therapy BPX-701 binds to tumor cells expressing PRAME, which may induce cell death in and halt the growth of PRAME-expressing cancer cells. The tumor-associated antigen PRAME is overexpressed by a variety of cancer cell types. If potential T-cell toxicity due to graft-versus-host disease (GvHD) occurs, the chemical dimerizer rimiducid (AP1903) can be adminstered. Rimiducid binds to the drug binding domain expressed by the BPX-701 T-cells, and triggers activation of the caspase-9 domain, which leads to caspase 9-mediated signaling, the induction of apoptosis and to selective and complete elimination of BPX-701 cells."], "t": []}], "preferred_name": "PRAME-targeting T-cell Receptor/Inducible Caspase 9 BPX-701", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1181163", "l": "Set of central neuroglial cells", "d": [], "t": []}], "preferred_name": "Set of central neuroglial cells", "taxa": []}
{"type": "biolink:Cell", "ic": 59.29301800676946, "identifiers": [{"i": "CL:0000113", "l": "mononuclear phagocyte", "d": ["A vertebrate phagocyte with a single nucleus."], "t": []}], "preferred_name": "mononuclear phagocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 45.79561010612745, "identifiers": [{"i": "UMLS:C1510724", "l": "Abnormal Glandular Cell", "d": [], "t": []}, {"i": "NCIT:C36764", "l": "Abnormal Glandular Cell", "d": [], "t": []}], "preferred_name": "Abnormal Glandular Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "CL:1000042", "l": "forebrain neuroblast", "d": ["Any neuroblast (sensu Vertebrata) that is part of some forebrain."], "t": []}], "preferred_name": "forebrain neuroblast", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4267792", "l": "CD25+CD127- cell", "d": [], "t": []}, {"i": "SNOMEDCT:1373172007", "l": "", "d": [], "t": []}], "preferred_name": "CD25+CD127- cell", "taxa": []}
{"type": "biolink:Cell", "ic": 70.98321298487613, "identifiers": [{"i": "UMLS:C1518629", "l": "Osteoclast-Like Giant Cell", "d": [], "t": []}, {"i": "NCIT:C36827", "l": "Osteoclast-Like Giant Cell", "d": ["A large, multinucleated cell that expresses osteoclast-specific markers."], "t": []}], "preferred_name": "Osteoclast-Like Giant Cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C3172555", "l": "Ciliated epithelial cell", "d": [], "t": []}, {"i": "SNOMEDCT:725724001", "l": "", "d": [], "t": []}], "preferred_name": "Ciliated epithelial cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5157328", "l": "CD16+CD56+CD3- | White blood cells | Cell markers", "d": [], "t": []}], "preferred_name": "CD16+CD56+CD3- | White blood cells | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5447541", "l": "Autologous HER2-targeted Dual-switch CAR-T Cells BPX-603", "d": [], "t": []}, {"i": "NCIT:C176990", "l": "Autologous HER2-targeted Dual-switch CAR-T Cells BPX-603", "d": ["A preparation of autologous T-lymphocytes that express a chimeric antigen receptor (CAR) for the human epidermal growth factor receptor 2 (EGFR2; HER2; HER-2) and a dual-switch composed of chemical inducer of dimerization (CID)-inducible co-activation domain MyD88/CD40 (inducible MC; iMC), in which both the MyD88 and CD40 lack their extracellular domains, and an inducible caspase 9 (iCasp9) safety switch (CaspaCIDe), consisting of the CID-binding domain coupled to the signaling domain of caspase-9, with potential immunomodulating and antineoplastic activities. Upon administration of autologous HER2-targeted dual-switch CAR-T cells BPX-603, the T-cells target and bind to HER2-expressing cancer cells. Upon subsequent administration of the CID agent rimiducid (AP1903), this agent targets and binds to the drug binding domain of iMC and activates iMC, which leads to the activation of both CD40- and MyD88-mediated signal transduction pathways. This allows for enhanced T-cell proliferation, persistence and resistance to T-cell exhaustion and upregulation of immunomodulatory cytokines within the tumor microenvironment (TME). This increases the anti-tumor activity of the administered T-cells, compared to T-cells without the iMC activation-switch. As these T-cells are engineered to only be fully activated by binding to both the HER2 antigen and rimiducid, T-cell proliferation, activity and toxicity can be controlled by adjusting the dose of rimiducid, thereby preventing uncontrolled T-cell activation which increases the safety of the administered T-cells. The binding of rimiducid to the CID binding domain of iCasp9 results in the cross-linking and dimerization of iCasp9, which causes its activation. This results in the induction of caspase-mediated apoptosis of the transduced cells and allows for the removal of inappropriately activated cells, thereby preventing toxicity of the administered cells. HER2, a tumor-associated antigen (TAA), plays a key role in tumor cell proliferation and tumor vascularization."], "t": []}], "preferred_name": "Autologous HER2-targeted Dual-switch CAR-T Cells BPX-603", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1182789", "l": "Epithelial cell of visceral layer of glomerular capsule", "d": [], "t": []}], "preferred_name": "Epithelial cell of visceral layer of glomerular capsule", "taxa": []}
{"type": "biolink:Cell", "ic": 90.871710685482, "identifiers": [{"i": "CL:0002016", "l": "CD71-low, GlyA-positive polychromatic erythroblast", "d": ["A polychromatiic erythroblast that is Gly-A-positive and CD71-low."], "t": []}], "preferred_name": "CD71-low, GlyA-positive polychromatic erythroblast", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0224523", "l": "Synovial fluid mononuclear cell", "d": [], "t": []}, {"i": "SNOMEDCT:77589000", "l": "", "d": [], "t": []}], "preferred_name": "Synovial fluid mononuclear cell", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "CL:0002677", "l": "naive regulatory T cell", "d": ["A regulatory T cell that has not encountered antigen."], "t": []}], "preferred_name": "naive regulatory T cell", "taxa": []}
{"type": "biolink:Cell", "ic": 79.35380886648232, "identifiers": [{"i": "UMLS:C5856640", "l": "Anti-CD22 CAR T Cells Preparation", "d": [], "t": []}, {"i": "NCIT:C201173", "l": "Anti-CD22 CAR T Cells Preparation", "d": ["Any preparation of chimeric antigen receptor (CAR) expressing T-lymphocytes that targets the tumor-associated antigen (TAA) CD22."], "t": []}], "preferred_name": "Anti-CD22 CAR T Cells Preparation", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C2984034", "l": "Allogeneic cytomegalovirus-specific cytotoxic T lymphocytes", "d": [], "t": []}, {"i": "NCIT:C91095", "l": "Allogeneic Cytomegalovirus-Specific Cytotoxic T lymphocytes", "d": ["A population of allogeneic cytotoxic T lymphocytes (CTLs) specifically reactive to the herpes virus cytomegalovirus (CMV) with potential immunomodulating and antiviral activities. Upon immunoprophylactic adoptive cell therapy infusion with allogeneic cytomegalovirus-specific cytotoxic T lymphocytes, these CTLs may help reconstitute CMV-specific CTL responses in CMV-infected immunocompromised hosts after allogeneic hematopoietic stem cell transplant, thereby potentially preventing the occurrence of CMV viral disease or reducing the amount of antiviral drug therapy."], "t": []}], "preferred_name": "Allogeneic cytomegalovirus-specific cytotoxic T lymphocytes", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0000483", "l": "bombesin stimulating hormone secreting cell", "d": ["A peptide hormone secreting cell that secretes bombesin stimulating hormone."], "t": []}], "preferred_name": "bombesin stimulating hormone secreting cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5961093", "l": "Autologous SIRPa-depleted Activated Macrophages SI-101", "d": [], "t": []}], "preferred_name": "Autologous SIRPa-depleted Activated Macrophages SI-101", "taxa": []}
{"type": "biolink:Cell", "ic": 90.871710685482, "identifiers": [{"i": "CL:0000563", "l": "endospore", "d": ["A rounded, inactive form that certain bacteria assume under conditions of extreme temperature, dryness, or lack of food. The bacterium develops a waterproof cell wall that protects it from being dried out or damaged."], "t": []}], "preferred_name": "endospore", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4023021", "l": "static gamma motor neuron", "d": ["A gamma motor neuron that innervates static nuclear bag fibers (bag2 fibers) and increases their firing, in response to an increase in the magnitude of change in length, and controls the static sensitivity of the stretch reflex."], "t": []}], "preferred_name": "static gamma motor neuron", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4042011", "l": "subpial interlaminar astrocyte", "d": ["An interlaminar astrocyte type whose soma is part of the upper first layer of the neocortex and its processes extend to a pia surface."], "t": []}], "preferred_name": "subpial interlaminar astrocyte", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1183209", "l": "Set of tympanic cells", "d": [], "t": []}], "preferred_name": "Set of tympanic cells", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0001028", "l": "CD7-positive lymphoid progenitor cell", "d": ["CD7-positive lymphoid progenitor cell is a lymphoid progenitor cell that is CD34-positive, CD7-positive and is CD45RA-negative."], "t": []}], "preferred_name": "CD7-positive lymphoid progenitor cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0002102", "l": "CD38-negative naive B cell", "d": ["A CD38-negative naive B cell is a mature B cell that has the phenotype CD38-negative, surface IgD-positive, surface IgM-positive, and CD27-negative, that has not yet been activated by antigen in the periphery."], "t": []}], "preferred_name": "CD38-negative naive B cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4307033", "l": "Astro-NT NN_1 Mecom astrocyte (Mmus)", "d": ["A astrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Dao (Mmus), Mecom (Mmus), Fbln5 (Mmus), Prelp (Mmus). It is distinguished from other Astro-NT NN_1 cells by expression of Mecom, Prelp. These cells are located in the Medulla, Cerebellum, brain , in or close to the regions: Ventral cochlear nucleus, Paraflocculus, Flocculus, Dorsal cochlear nucleus . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5213 Astro-NT NN_1."], "t": []}], "preferred_name": "Astro-NT NN_1 Mecom astrocyte (Mmus)", "taxa": []}
{"type": "biolink:Cell", "ic": 92.76600187037766, "identifiers": [{"i": "UMLS:C1879556", "l": "Adenocarcinoma Cell with Foamy Cytoplasm", "d": [], "t": []}, {"i": "NCIT:C60526", "l": "Adenocarcinoma Cell with Foamy Cytoplasm", "d": [], "t": []}], "preferred_name": "Adenocarcinoma Cell with Foamy Cytoplasm", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5157667", "l": "CD8+CD25+ cells | Blood | Cell markers", "d": [], "t": []}], "preferred_name": "CD8+CD25+ cells | Blood | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0933801", "l": "Glandular columnar cell", "d": [], "t": []}], "preferred_name": "Glandular columnar cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5427285", "l": "Nucleated cells | Sputum | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Nucleated cells | Sputum | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": 84.83823963392128, "identifiers": [{"i": "CL:0004116", "l": "retinal ganglion cell C", "d": ["A retinal ganglion with cell medium cell bodies and medium to large dendritic fields."], "t": []}], "preferred_name": "retinal ganglion cell C", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5380999", "l": "Cells.CD8.HLA-B35 CMV specific", "d": [], "t": []}], "preferred_name": "Cells.CD8.HLA-B35 CMV specific", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0011023", "l": "CD25+ mast cell", "d": ["A mast cell that is CD25+."], "t": []}], "preferred_name": "CD25+ mast cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C4724877", "l": "Autologous Anti-BCMA-CAR-4-1BB-CD3zeta-EGFRt-expressing CD4+/CD8+ T-lymphocytes", "d": [], "t": []}, {"i": "NCIT:C148177", "l": "Autologous Anti-BCMA-CAR-4-1BB-CD3zeta-EGFRt-expressing CD4+/CD8+ T-lymphocytes", "d": ["A preparation of an approximately equal ratio of autologous CD4- and CD8-positive T-lymphocytes that have been ex vivo transduced with a genetically-engineered self-inactivating (SIN) lentiviral vector (LV) expressing a chimeric antigen receptor (CAR) containing a single chain variable fragment (scFv) specific for the human tumor-associated antigen (TAA) B-cell maturation antigen (BCMA; tumor necrosis factor receptor superfamily member 17; TNFRSF17) fused to the co-stimulatory domain of 4-1BB (CD137), the CD3-zeta (CD3z) T-cell signaling domain, and a truncated form of the human epidermal growth factor receptor (EGFRt), with potential immunostimulating and antineoplastic activities. Upon administration, the autologous anti-BCMA-CAR-4-1BB-CD3zeta-EGFRt-expressing CD4+/CD8+ T-lymphocytes specifically recognize and induce selective toxicity against BCMA-expressing tumor cells. Devoid of both ligand binding domains and tyrosine kinase activity, the expressed EGFRt facilitates both in vivo detection of the administered, transduced T-cells and can promote elimination of those cells through a cetuximab-induced antibody-dependent cellular cytotoxicity (ADCC) response. BCMA, a tumor-specific antigen and a receptor for both a proliferation-inducing ligand (APRIL) and B-cell activating factor (BAFF), is a member of the tumor necrosis factor receptor superfamily (TNFRSF) and plays a key role in plasma cell survival. BCMA is found on the surfaces of plasma cells and is overexpressed on malignant plasma cells."], "t": []}], "preferred_name": "Autologous Anti-BCMA-CAR-4-1BB-CD3zeta-EGFRt-expressing CD4+/CD8+ T-lymphocytes", "taxa": []}
{"type": "biolink:Cell", "ic": 92.76600187037766, "identifiers": [{"i": "CL:0003036", "l": "M7 retinal ganglion cell", "d": ["A monostratified retinal ganglion cell with large soma and large dendritic field, with medium dendritic arbor, and has dendrites in layers 2 and 5."], "t": []}], "preferred_name": "M7 retinal ganglion cell", "taxa": []}
{"type": "biolink:Cell", "ic": 75.54735764213513, "identifiers": [{"i": "UMLS:C1514273", "l": "Postgerminal Center Marginal Zone B-Lymphocyte", "d": [], "t": []}, {"i": "NCIT:C38334", "l": "Postgerminal Center Marginal Zone B-Lymphocyte", "d": [], "t": []}], "preferred_name": "Postgerminal Center Marginal Zone B-Lymphocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 57.60953716472112, "identifiers": [{"i": "CL:0000057", "l": "fibroblast", "d": ["A connective tissue cell which secretes an extracellular matrix rich in collagen and other macromolecules. Flattened and irregular in outline with branching processes; appear fusiform or spindle-shaped."], "t": []}], "preferred_name": "fibroblast", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C3831434", "l": "Autologous Mesenchymal Stem Cells Apceth_101", "d": [], "t": []}, {"i": "NCIT:C113803", "l": "Autologous Mesenchymal Stem Cells Apceth_101", "d": ["Human autologous mesenchymal stem cells (MSCs) harvested from the bone marrow of a patient and genetically modified with a self-inactivating retroviral vector expressing the suicide gene herpes simplex virus thymidine kinase (HSV-TK), that can be used to activate synthetic acyclic guanosine analogues when co-administered. Upon intravenous administration of autologous mesenchymal stem cells apceth_101, the cells are actively recruited to the tumor stroma, differentiate into more mature mesenchymal cells, and become part of the tumor microenvironment. When a synthetic acyclic guanosine analogue, such as ganciclovir, is co-administered, the HSV-TK within the HSV-TK-transduced MSCs will monophosphorylate this prodrug. Subsequently the monophosphate form is further converted to the diphosphate form and then to its active triphosphate form by cellular kinases. The active form of ganciclovir kills the HSV-TK-transduced MSCs and leads to a bystander effect, which eliminates neighboring cancer cells. Therefore, synthetic acyclic guanosine analogues are activated only at the tumor site, which increases their local efficacy and reduces systemic toxicity."], "t": []}], "preferred_name": "Autologous Mesenchymal Stem Cells Apceth_101", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5163742", "l": "Erythrocytes.dysmorphic | Urine sediment | Urinalysis", "d": [], "t": []}], "preferred_name": "Erythrocytes.dysmorphic | Urine sediment | Urinalysis", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "CL:0002595", "l": "smooth muscle cell of the subclavian artery", "d": ["A smooth muscle cell of the subclavian artery."], "t": []}], "preferred_name": "smooth muscle cell of the subclavian artery", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4267785", "l": "CD27+IgD- cell", "d": [], "t": []}, {"i": "SNOMEDCT:1373191007", "l": "", "d": [], "t": []}], "preferred_name": "CD27+IgD- cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5155308", "l": "Blister cells | Blood | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Blister cells | Blood | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4079012", "l": "lumbar dorsal root ganglion endothelin-1 neuron", "d": ["A sensory neuron whose soma is located in the lumbar dorsal root ganglion and that expresses endothelin-1 (EDN1). In rat DRG, EDN1 immunoreactivity has been detected in a subset of neuron somata (Giaid et al. 1989, PMID:2678100). Endothelin-1 acts as an endogenous pain mediator, sensitizing nociceptors through activation of ETA and ETB receptors, and these neurons are implicated in vascular pain signalling. EDN1-expressing DRG neurons have been characterized in rat; their prevalence and properties in human DRG remain to be systematically determined, as EDN1 is not yet represented in human DRG single-cell transcriptomic datasets."], "t": []}], "preferred_name": "lumbar dorsal root ganglion endothelin-1 neuron", "taxa": []}
{"type": "biolink:Cell", "ic": 85.53200374075534, "identifiers": [{"i": "UMLS:C1513170", "l": "Metaplastic Cell", "d": [], "t": []}, {"i": "NCIT:C36786", "l": "Metaplastic Cell", "d": [], "t": []}], "preferred_name": "Metaplastic Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 90.871710685482, "identifiers": [{"i": "UMLS:C1512995", "l": "Maria ES Cell Line", "d": [], "t": []}, {"i": "NCIT:C20274", "l": "Maria ES Cell Line", "d": [], "t": []}], "preferred_name": "Maria ES Cell Line", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C4085976", "l": "Anti-MUC1 CAR-transduced Autologous T-lymphocytes", "d": [], "t": []}, {"i": "NCIT:C124646", "l": "Anti-MUC1 CAR-transduced Autologous T-lymphocytes", "d": ["Autologous T-lymphocytes transduced with a retroviral vector expressing a chimeric antigen receptor (CAR) consisting of a single chain variable fragment (scFv) against the human tumor-associated epithelial antigen mucin 1 (MUC1), with potential immunomodulating and antineoplastic activities. Autologous PBLs from a patient with MUC1-positive cancer are transduced with a retroviral vector that encodes the CAR gene specific for MUC1. After expansion in culture and reintroduction into the patient, anti-MUC1 CAR-transduced autologous T-lymphocytes target and induce selective toxicity in MUC1-expressing tumor cells. MUC-1 is a human, hypoglycosylated tumor-associated antigen (TAA) overexpressed by epithelial cancer cells."], "t": []}], "preferred_name": "Anti-MUC1 CAR-transduced Autologous T-lymphocytes", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5186089", "l": "CD34 cells | Blood product unit | Cell markers", "d": [], "t": []}], "preferred_name": "CD34 cells | Blood product unit | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": 92.76600187037766, "identifiers": [{"i": "UMLS:C0228071", "l": "Ganglion cell", "d": [], "t": []}, {"i": "NCIT:C13155", "l": "Ganglion Cell", "d": ["A type of interneuron that conveys information to the brain."], "t": []}, {"i": "SNOMEDCT:53102003", "l": "", "d": [], "t": []}], "preferred_name": "Ganglion cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0598091", "l": "stable cell line", "d": [], "t": []}], "preferred_name": "stable cell line", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4307040", "l": "Astro-TE NN_1 Lncpint astrocyte (Mmus)", "d": ["A astrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Myoc (Mmus), Dio2 (Mmus), Lncpint (Mmus). It is distinguished from other Astro-TE NN_1 cells by expression of Myoc, Lncpint. These cells are located in the brain . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5220 Astro-TE NN_1."], "t": []}], "preferred_name": "Astro-TE NN_1 Lncpint astrocyte (Mmus)", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1955257", "l": "Erythrocytes.fresh", "d": [], "t": []}], "preferred_name": "Erythrocytes.fresh", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5216245", "l": "Lymphocytes.immunoblastic|NCnc|Pt|Bld", "d": [], "t": []}], "preferred_name": "Lymphocytes.immunoblastic|NCnc|Pt|Bld", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C2709116", "l": "CD5+CD19+CD38+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:1373088009", "l": "", "d": [], "t": []}], "preferred_name": "CD5+CD19+CD38+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": 76.78008365410358, "identifiers": [{"i": "UMLS:C1708912", "l": "Malignant Spindle-Shaped Fibrohistiocytic Cell", "d": [], "t": []}, {"i": "NCIT:C49072", "l": "Malignant Spindle-Shaped Fibrohistiocytic Cell", "d": [], "t": []}], "preferred_name": "Malignant Spindle-Shaped Fibrohistiocytic Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 84.83823963392128, "identifiers": [{"i": "CL:0000907", "l": "central memory CD8-positive, alpha-beta T cell", "d": ["CD8-positive, alpha-beta memory T cell with the phenotype CCR7-positive, CD127-positive, CD45RA-negative, CD45RO-positive, and CD25-negative."], "t": []}], "preferred_name": "central memory CD8-positive, alpha-beta T cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1512505", "l": "Breast Cancer Cell", "d": [], "t": []}, {"i": "NCIT:C12959", "l": "Breast Cancer Cell", "d": ["Cells found in human breast cancers or extracted from cancers as established cell lines"], "t": []}], "preferred_name": "Breast Cancer Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "CL:0000456", "l": "mineralocorticoid secreting cell", "d": ["Any secretory cell that is capable of some mineralocorticoid secretion."], "t": []}], "preferred_name": "mineralocorticoid secreting cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C2984029", "l": "Autologous IL-21-Modulated CD8+ MART1-Specific T Cells", "d": [], "t": []}, {"i": "NCIT:C91088", "l": "Autologous IL-21-Modulated CD8+ MART1-Specific T Cells", "d": ["A preparation of interleukin 21 (IL-21) stimulated, CD8+ T-lymphocytes sensitized to MART-1 (melanoma antigen recognized by T-cells) antigen with potential immunostimulating and antineoplastic activities. CD8+ T-lymphocytes are exposed ex vivo to autologous dendritic cells (DCs) pulsed with MART-1 antigen peptide and grown in the presence of IL-21. These tumor-reactive T-cells may stimulate a host immune response against tumor cells expressing the MART-1 antigen, resulting in tumor cell lysis. MART-1 is expressed by certain types of melanoma cells. IL-21, a cytokine involved in the regulation of cellular immune responses, may play a key role during priming of antigen-specific CD8+ T cells and may enhance proliferation of the CTLs."], "t": []}], "preferred_name": "Autologous IL-21-Modulated CD8+ MART1-Specific T Cells", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0009027", "l": "transit amplifying cell of appendix", "d": ["A transit amplifying cell that is part of a crypt of Lieberkuhn of large intestine."], "t": []}], "preferred_name": "transit amplifying cell of appendix", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C6064451", "l": "CD4+TNF alpha+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:1381849005", "l": "", "d": [], "t": []}], "preferred_name": "CD4+TNF alpha+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5959682", "l": "Autologous Anti-CD22 CAR-T Cells CLIC-2201", "d": [], "t": []}, {"i": "NCIT:C206263", "l": "Autologous Anti-CD22 CAR-T Cells CLIC-2201", "d": ["A preparation of autologous T-lymphocytes engineered to express a chimeric antigen receptor (CAR) targeting the tumor-associated antigen (TAA) CD22, with potential antineoplastic activity. Upon administration, autologous anti-CD22 CAR-T cells CLIC-2201 recognize and kill CD22-expressing tumor cells. CD22, a B-lineage-restricted, transmembrane phosphoglycoprotein, is expressed on malignant B-cells."], "t": []}], "preferred_name": "Autologous Anti-CD22 CAR-T Cells CLIC-2201", "taxa": []}
{"type": "biolink:Cell", "ic": 81.743421370964, "identifiers": [{"i": "UMLS:C1510780", "l": "Adenocarcinoma Cell with Eosinophilic Granular Cytoplasm", "d": [], "t": []}, {"i": "NCIT:C36880", "l": "Adenocarcinoma Cell with Eosinophilic Granular Cytoplasm", "d": [], "t": []}], "preferred_name": "Adenocarcinoma Cell with Eosinophilic Granular Cytoplasm", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0002534", "l": "mature CD16-positive myeloid dendritic cell", "d": ["A mature CD16-positive myeloid dendritic cell is CD80-high, CD83-positive, CD86-high, and MHCII-high."], "t": []}], "preferred_name": "mature CD16-positive myeloid dendritic cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C4761323", "l": "TCR alpha/beta/CD19-depleted Allogeneic Hematopoietic Progenitor Cells", "d": [], "t": []}, {"i": "NCIT:C157370", "l": "TCR alpha/beta/CD19-depleted Allogeneic Hematopoietic Progenitor Cells", "d": ["A preparation of hematopoietic progenitor cells (HPCs) from a haploidentical donor that have been depleted of T-cell receptor (TCR) alpha and beta (TCRa/b+) as well as CD19-positive (CD19+) cells, that can potentially be used for immune reconstitution purposes. The TCR alpha/beta/CD19-depleted HPCs contain high amounts of natural killer (NK) cells, gamma/delta T-cells, CD34+ stem cells, monocytes, and dendritic cells (DCs), while devoid of alpha/beta T-cells and CD19-positive B-cells. The TCR alpha/beta/CD19-depleted HPCs are used for allogeneic hematopoietic cell transplantation (HCT) and may allow for rapid and sustained engraftment, rapid immune reconstitution, and may prevent or reduce graft-versus-host disease (GvHD)."], "t": []}], "preferred_name": "TCR alpha/beta/CD19-depleted Allogeneic Hematopoietic Progenitor Cells", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1268009", "l": "Basophilic granulocytic cell", "d": [], "t": []}, {"i": "SNOMEDCT:127917000", "l": "", "d": [], "t": []}], "preferred_name": "Basophilic granulocytic cell", "taxa": []}
{"type": "biolink:Cell", "ic": 89.40238429118027, "identifiers": [{"i": "CL:0002307", "l": "brush border cell of the proximal tubule", "d": ["A brush border epithelial cell located in the proximal tubule of the kidney, essential for reabsorbing substances like glucose and amino acids from the glomerular filtrate. These cells also secrete organic ions, playing a crucial role in maintaining kidney homeostasis, including electrolyte and acid-base balance, and excreting metabolic waste."], "t": []}], "preferred_name": "brush border cell of the proximal tubule", "taxa": []}
{"type": "biolink:Cell", "ic": 87.18682603146104, "identifiers": [{"i": "UMLS:C1881595", "l": "Malignant Small Round Cell with Scant Amount of Dark Granular Cytoplasm", "d": [], "t": []}, {"i": "NCIT:C60805", "l": "Malignant Small Round Cell with Scant Amount of Dark Granular Cytoplasm", "d": [], "t": []}], "preferred_name": "Malignant Small Round Cell with Scant Amount of Dark Granular Cytoplasm", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1699193", "l": "african green monkey kidney cells", "d": [], "t": []}], "preferred_name": "african green monkey kidney cells", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5216229", "l": "Leukocytes other|NCnc|Pt|Synv fld", "d": [], "t": []}], "preferred_name": "Leukocytes other|NCnc|Pt|Synv fld", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4079032", "l": "thoracic dorsal root ganglion Nav1.9 neuron", "d": ["A nociceptor whose soma is located in the thoracic dorsal root ganglion and that expresses the voltage-gated sodium channel Nav1.9 (encoded by SCN11A). This neuron is characterized by a persistent, tetrodotoxin-resistant sodium current that modulates resting membrane potential and amplifies subthreshold depolarizations, contributing to enhanced excitability during inflammation (Dib-Hajj et al. 2002, PMID:11972962). In human DRG, Nav1.9-immunoreactive neurons constitute approximately 26% of TrkA-positive neurons, a significantly higher proportion than the 12% observed in mouse (Rostock et al. 2018, PMID:29229553), suggesting species differences in inflammatory pain processing."], "t": []}], "preferred_name": "thoracic dorsal root ganglion Nav1.9 neuron", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1267993", "l": "Lymphocyte positive for CD107A antigen", "d": [], "t": []}, {"i": "SNOMEDCT:117433008", "l": "", "d": [], "t": []}], "preferred_name": "Lymphocyte positive for CD107A antigen", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5848433", "l": "BB305 Transduced SCD CD34+ HSCs bb1111", "d": [], "t": []}], "preferred_name": "BB305 Transduced SCD CD34+ HSCs bb1111", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0002550", "l": "fibroblast of the conjunctiva", "d": ["A fibroblast that is part of the conjuctiva of the eye."], "t": []}], "preferred_name": "fibroblast of the conjunctiva", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C6055544", "l": "CAP-1002A", "d": [], "t": []}], "preferred_name": "CAP-1002A", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0002617", "l": "adipocyte of breast", "d": ["An adipocyte that is part of the breast."], "t": []}], "preferred_name": "adipocyte of breast", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C0314589", "l": "Granulocyte-Macrophage Colony Forming Units", "d": [], "t": []}, {"i": "NCIT:C121475", "l": "Granulocyte-Macrophage Colony Forming Unit", "d": ["A unit of viable cell concentration defined as the minimum number of hematopoietic stem cells able to produce a detectable colony of granulocyte-macrophage lineage cells."], "t": []}], "preferred_name": "Granulocyte-Macrophage Colony Forming Units", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5157286", "l": "CD126 blasts | Blood | Cell markers", "d": [], "t": []}], "preferred_name": "CD126 blasts | Blood | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0008027", "l": "rod bipolar cell (sensu Mus)", "d": ["A bipolar neuron found in the retina that is synapsed by rod photoreceptor cells.  These neurons have axons that arborize and synapse to targets in inner plexiform layers 4 and 5 and depolarize in response to light."], "t": []}], "preferred_name": "rod bipolar cell (sensu Mus)", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4033041", "l": "CCL3-positive alveolar macrophage", "d": ["An alveolar macrophage that expresses CCL3."], "t": []}], "preferred_name": "CCL3-positive alveolar macrophage", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5854479", "l": "Autologous Tumor Infiltrating Lymphocytes GT201", "d": [], "t": []}, {"i": "NCIT:C200139", "l": "Autologous Tumor Infiltrating Lymphocytes GT201", "d": ["A preparation of autologous tumor infiltrating lymphocytes (TILs) derived from each patient's resected tumor and expanded ex vivo, with potential immunomodulating and antineoplastic activities. Upon administration back into the patient, the autologous TILs GT201 specifically recognize and kill the patient's tumor cells."], "t": []}], "preferred_name": "Autologous Tumor Infiltrating Lymphocytes GT201", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1440334", "l": "CD58+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:1372911004", "l": "", "d": [], "t": []}], "preferred_name": "CD58+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1545484", "l": "Non-squamous epithelial cell", "d": [], "t": []}, {"i": "SNOMEDCT:725264003", "l": "", "d": [], "t": []}], "preferred_name": "Non-squamous epithelial cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1317395", "l": "Immature granulocyte", "d": [], "t": []}, {"i": "NCIT:C13113", "l": "Immature Granulocyte", "d": ["A not-yet-mature white blood cell with staining granules in its cytoplasm. The staining granules may be neutrophilic, acidophilic, or basophilic in character. There are indications that an immature granulocyte count is a better measure of infection and sepsis than a total white blood cell count and comparable to absolute neutrophil count."], "t": []}, {"i": "SNOMEDCT:726594001", "l": "", "d": [], "t": []}], "preferred_name": "Immature granulocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 67.65179433958558, "identifiers": [{"i": "CL:0011020", "l": "neural progenitor cell", "d": ["An undifferentiated cell derived from a neural stem cell, with a limited capacity to self-renew (Dibajnia and Morshead, 2013) and the ability to generate multiple types of lineage-restricted progenitors, contributing to the formation of neurons, astrocytes, and oligodendrocytes."], "t": []}], "preferred_name": "neural progenitor cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0004227", "l": "flat bistratified amacrine cell", "d": ["A bistratified amacrine cell with a small dendritic field. Flat bistratified amacrine cells have post-synaptic terminals both on the border of S1 and S2, and on the border of S3 and S4. This cell type releases the neurotransmitter glycine."], "t": []}], "preferred_name": "flat bistratified amacrine cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C3900007", "l": "Autologous 4-1BB Selected Tumor Infiltrating Lymphocytes", "d": [], "t": []}, {"i": "NCIT:C119703", "l": "Autologous 4-1BB Selected Tumor Infiltrating Lymphocytes", "d": ["A preparation of autologous tumor infiltrating lymphocytes (TILs) expressing the co-stimulatory signaling domain 4-1BB (CD137), with potential antineoplastic activity. TILs are isolated from a patient's tumor and those expressing 4-1BB are selected for expansion in vitro. Upon re-infusion into the patient, the 4-1BB-expressing TILs re-infiltrate the tumor to initiate tumor cell lysis. 4-1BB, a member of the tumor necrosis factor (TNF) receptor superfamily, enhances TIL survival and antitumor cytolytic activity."], "t": []}], "preferred_name": "Autologous 4-1BB Selected Tumor Infiltrating Lymphocytes", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C3847488", "l": "Cells.CD3-CD4+", "d": [], "t": []}], "preferred_name": "Cells.CD3-CD4+", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5216196", "l": "Blasts|NCnc|Pt|Bld", "d": [], "t": []}], "preferred_name": "Blasts|NCnc|Pt|Bld", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C2340121", "l": "Fusiform cell of cerebral cortex", "d": [], "t": []}], "preferred_name": "Fusiform cell of cerebral cortex", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5908948", "l": "Arlocabtagene autoleucel", "d": [], "t": []}], "preferred_name": "Arlocabtagene autoleucel", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5160254", "l": "Clue cells | Vaginal | Microbiology", "d": [], "t": []}], "preferred_name": "Clue cells | Vaginal | Microbiology", "taxa": []}
{"type": "biolink:Cell", "ic": 84.83823963392128, "identifiers": [{"i": "CL:0002006", "l": "Kit-positive, CD34-negative megakaryocyte erythroid progenitor cell", "d": ["A megakaryocyte erythroid progenitor cell that is Kit-positive and is Sca1-negative, CD34-negative, CD90-negative, IL7r-alpha-negative and Fcgr II/III-low."], "t": []}], "preferred_name": "Kit-positive, CD34-negative megakaryocyte erythroid progenitor cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4518151", "l": "Population of all spermatozoa with angled midpiece in portion of fluid", "d": [], "t": []}, {"i": "SNOMEDCT:725236008", "l": "", "d": [], "t": []}], "preferred_name": "Population of all spermatozoa with angled midpiece in portion of fluid", "taxa": []}
{"type": "biolink:Cell", "ic": 92.76600187037766, "identifiers": [{"i": "CL:0002411", "l": "Vgamma1.1-positive, Vdelta6.3-negative thymocyte", "d": ["A gamma-delta receptor that expresses Vgamma1.1 but does not express Vdelta6.3 chains in the T-cell receptor."], "t": []}], "preferred_name": "Vgamma1.1-positive, Vdelta6.3-negative thymocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 90.871710685482, "identifiers": [{"i": "CL:0002015", "l": "Kit-negative, Ly-76 high polychromatophilic erythroblast", "d": ["A polychromatophilic erythroblast that is Lyg 76-high and is Kit-negative."], "t": []}], "preferred_name": "Kit-negative, Ly-76 high polychromatophilic erythroblast", "taxa": []}
{"type": "biolink:Cell", "ic": 90.871710685482, "identifiers": [{"i": "UMLS:C1514035", "l": "Neoplastic Myeloblast with Abundant Basophilic Cytoplasm", "d": [], "t": []}, {"i": "NCIT:C37176", "l": "Neoplastic Myeloblast with Abundant Basophilic Cytoplasm", "d": [], "t": []}], "preferred_name": "Neoplastic Myeloblast with Abundant Basophilic Cytoplasm", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1518889", "l": "Paraimmunoblast", "d": [], "t": []}, {"i": "NCIT:C36989", "l": "Paraimmunoblast", "d": [], "t": []}], "preferred_name": "Paraimmunoblast", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4249177", "l": "Primitive endodermal cell", "d": [], "t": []}], "preferred_name": "Primitive endodermal cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1440260", "l": "CD16b+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:1372855006", "l": "", "d": [], "t": []}], "preferred_name": "CD16b+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": 79.35380886648232, "identifiers": [{"i": "CL:0000652", "l": "pinealocyte", "d": ["This cell type produces and secretes melatonin and forms the pineal parenchyma. Extending from each cell body, which has a spherical, oval or lobulated mucleus, are one or more tortuous basophilic processes, containing parallel microtubules known as synaptic ribbons. These processes end in expanded terminal buds near capillaries or less, frequently, ependymal cells of the pineal recess. The terminal buds contain granular endoplasmic reticulum, mitochondria and electron-dense cored vesicles, which store monoamines and polypeptide hormones, release of which appears to require sympathetic innervation."], "t": []}, {"i": "UMLS:C1519090", "l": "Pinealocyte", "d": [], "t": []}, {"i": "NCIT:C33323", "l": "Pinealocyte", "d": ["A cell of the pineal body with long processes ending in bulbous expansions. Pineocytes receive a direct innervation from sympathetic neurons that form recognizable synapses. The club-shaped endings of pineocyte processes terminate in perivascular spaces surrounding capillaries."], "t": []}], "preferred_name": "pinealocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 89.40238429118027, "identifiers": [{"i": "CL:0002486", "l": "strial intermediate cell", "d": ["A melanocyte located between the epithelial marginal cell layer and the mesodermal basal cell layer within the intrastrial space; the predominant cellular component of the electrogenic machinery that generates an endocochlear potential (80-100 mV) ."], "t": []}], "preferred_name": "strial intermediate cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4322672", "l": "CD23+ hemal cell", "d": [], "t": []}], "preferred_name": "CD23+ hemal cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5785374", "l": "Autologous Tumor-infiltrating Lymphocytes HS-IT101", "d": [], "t": []}, {"i": "NCIT:C192685", "l": "Autologous Tumor-infiltrating Lymphocytes HS-IT101", "d": ["A preparation of autologous tumor infiltrating lymphocytes (TILs) derived from each patient's resected tumor and expanded ex vivo, with potential immunomodulating and antineoplastic activities. Upon administration back into the patient, the autologous TILs HS-IT101 specifically recognize and kill the patient's tumor cells."], "t": []}], "preferred_name": "Autologous Tumor-infiltrating Lymphocytes HS-IT101", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4699468", "l": "Light-chain negative plasma cells", "d": [], "t": []}], "preferred_name": "Light-chain negative plasma cells", "taxa": []}
{"type": "biolink:Cell", "ic": 84.83823963392128, "identifiers": [{"i": "CL:0000432", "l": "reticular cell", "d": ["A fibroblast that synthesizes collagen and uses it to produce reticular fibers, thus providing structural support. Reticular cells are found in many organs, including the spleen, lymph nodes and kidneys. Subtypes of reticular cells include epithelial, mesenchymal, and fibroblastic reticular cells. Fibroblastic reticular cells are involved in directing B cells and T cells to specific regions within a tissue, whereas epithelial and mesenchymal reticular cells are associated with certain areas of the brain."], "t": []}], "preferred_name": "reticular cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5571671", "l": "Erythrocytes|NCnc|Pt|BAL", "d": [], "t": []}], "preferred_name": "Erythrocytes|NCnc|Pt|BAL", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5157325", "l": "CD16 cells | Blood | Cell markers", "d": [], "t": []}], "preferred_name": "CD16 cells | Blood | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": 92.76600187037766, "identifiers": [{"i": "CL:0000374", "l": "trichogen cell", "d": ["An epidermal cell that is part of a cell cluster organ of the insect integument (such as a sensillum) and that secretes a cuticular specialization, often in the form of a hair, bristle, peg or scale. The base of this specialization is often surrounded by a socket produced by a closely associated tormogen cell."], "t": []}], "preferred_name": "trichogen cell", "taxa": []}
{"type": "biolink:Cell", "ic": 89.40238429118027, "identifiers": [{"i": "UMLS:C1517170", "l": "Fibrillary Neoplastic Astrocyte", "d": [], "t": []}, {"i": "NCIT:C37129", "l": "Fibrillary Neoplastic Astrocyte", "d": ["A neoplastic astrocyte characterized by the presence of an atypical nucleus (large, irregular, or hyperchromatic), scant amount of cytoplasm, and cell processes that contribute to the formation of a fibrillary matrix."], "t": []}], "preferred_name": "Fibrillary Neoplastic Astrocyte", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5157613", "l": "CD55 RBC | Blood | Cell markers", "d": [], "t": []}], "preferred_name": "CD55 RBC | Blood | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0871657", "l": "Auditory Neurons", "d": [], "t": []}], "preferred_name": "Auditory Neurons", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0684116", "l": "megaloblast of Sabin", "d": [], "t": []}], "preferred_name": "megaloblast of Sabin", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:1001287", "l": "outer medulla vasa recta descending limb cell", "d": ["Any vasa recta descending limb cell that is part of some outer medulla descending vasa recta."], "t": []}], "preferred_name": "outer medulla vasa recta descending limb cell", "taxa": []}
{"type": "biolink:Cell", "ic": 92.76600187037766, "identifiers": [{"i": "CL:1001435", "l": "periglomerular cell", "d": ["The small neuron in the glomerular layer of the olfactory bulb whose dendrites arborize within a glomerulus, where it receives synaptic input from olfactory receptor cell axon terminals, and also engages in dendrodendritic interactions with mitral and tufted cell dendrites; uses both GABA and dopamine as a neurotransmitter."], "t": []}], "preferred_name": "periglomerular cell", "taxa": []}
{"type": "biolink:Cell", "ic": 90.871710685482, "identifiers": [{"i": "UMLS:C1708946", "l": "Activated Mature Gamma/Delta T-Lymphocyte with a Cytotoxic Phenotype", "d": [], "t": []}, {"i": "NCIT:C45341", "l": "Activated Mature Gamma/Delta T-Lymphocyte with a Cytotoxic Phenotype", "d": ["A mature lymphocyte whose T cell receptor, a gamma polypeptide chain linked by a disulfide bridge to a delta polypeptide chain, has recognized specific foreign antigens and self MHC antigens.  This type of cell is most often found in the gut and epidermis."], "t": []}], "preferred_name": "Activated Mature Gamma/Delta T-Lymphocyte with a Cytotoxic Phenotype", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4070015", "l": "pyloric dilator neuron", "d": ["A motor neuron that controls the cardiopyloric valve."], "t": []}], "preferred_name": "pyloric dilator neuron", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C4528183", "l": "Derived Dental Pulp", "d": [], "t": []}, {"i": "NCIT:C138973", "l": "Derived Dental Pulp", "d": ["Dental pulp from a tooth."], "t": []}], "preferred_name": "Derived Dental Pulp", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0002287", "l": "type IV taste receptor cell", "d": ["A rounded, mitotically active stem cell which is the source of new cells of the taste bud; located basally."], "t": []}, {"i": "UMLS:C1179135", "l": "Type IV taste bud cell", "d": [], "t": []}, {"i": "NCIT:C13185", "l": "Taste Bud Basal Cell", "d": ["A small, round cell found in the lower part of the epidermis of the taste bud. It differentiates into a new receptor cell and renewed about every 10 days."], "t": []}], "preferred_name": "type IV taste receptor cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4033105", "l": "superior cervical ganglion SST neuron", "d": ["A sympathetic neuron that has the soma located in the superior cervical ganglion and expresses the marker somatostatin (SST)."], "t": []}], "preferred_name": "superior cervical ganglion SST neuron", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1267991", "l": "CD105+ lymphocyte", "d": [], "t": []}, {"i": "SNOMEDCT:117431005", "l": "", "d": [], "t": []}], "preferred_name": "CD105+ lymphocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 79.64650900338474, "identifiers": [{"i": "UMLS:C1515881", "l": "Activated Natural Killer Cell", "d": [], "t": []}, {"i": "NCIT:C39609", "l": "Activated Natural Killer Cell", "d": ["A cell that acts in a similar manner to a cytotoxic T cell and must be activated like a cytotoxic T cell. However, the killing exhibited by the cell is nonspecific and the cell does not require antigen/MHC recognition on the target cell. The lineage of the natural killer (NK) cell is currently not well understood."], "t": []}], "preferred_name": "Activated Natural Killer Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0009059", "l": "plasma cell of medullary sinus of lymph node", "d": ["A plasma cell that is located in the medullary sinus of the lymph node."], "t": []}], "preferred_name": "plasma cell of medullary sinus of lymph node", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C2325536", "l": "H III cell of retina", "d": [], "t": []}], "preferred_name": "H III cell of retina", "taxa": []}
{"type": "biolink:Cell", "ic": 90.871710685482, "identifiers": [{"i": "UMLS:C1514584", "l": "Pseudo-Gaucher Cell", "d": [], "t": []}, {"i": "NCIT:C37078", "l": "Pseudo-Gaucher Cell", "d": [], "t": []}], "preferred_name": "Pseudo-Gaucher Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0003050", "l": "S cone cell", "d": ["A cone cell that detects short wavelength light. Exact peak of spectra detected differs between species. In humans, spectra peaks at 420-440 nm."], "t": []}], "preferred_name": "S cone cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1276852", "l": "Entire parathyroid transitional cell", "d": [], "t": []}, {"i": "SNOMEDCT:177728006", "l": "", "d": [], "t": []}], "preferred_name": "Entire parathyroid transitional cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5173061", "l": "Microcytes | Urine | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Microcytes | Urine | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1512310", "l": "HL60", "d": [], "t": []}, {"i": "NCIT:C19433", "l": "HL60", "d": ["HL-60 is a promyelocytic cell line derived by S.J. Collins, et al. Peripheral blood leukocytes were obtained by leukopheresis from a 36-year-old Caucasian female with acute promyelocytic leukemia. The cells resemble promyelocytes. In vitro the cells can be induced to differentiate terminally into granulocyte-like cells or monocyte/macrophage-like cells, depending on the inducing agent. This cell line has been used as a model for human myeloid cell differentiation."], "t": []}], "preferred_name": "HL60", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0000324", "l": "metanephric mesenchyme stem cell", "d": [], "t": []}], "preferred_name": "metanephric mesenchyme stem cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1268444", "l": "Nonhematic cell", "d": [], "t": []}, {"i": "SNOMEDCT:115611000", "l": "", "d": [], "t": []}], "preferred_name": "Nonhematic cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5157269", "l": "CD11b cells | Blood | Cell markers", "d": [], "t": []}], "preferred_name": "CD11b cells | Blood | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5178678", "l": "Pseudo Pelger Huet cells | Blood | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Pseudo Pelger Huet cells | Blood | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": 92.76600187037766, "identifiers": [{"i": "CL:0002040", "l": "immature NK T cell stage II, mouse", "d": ["A CD24-low, CD44-negative, NK1.1-negative NK T cell."], "t": []}], "preferred_name": "immature NK T cell stage II, mouse", "taxa": []}
{"type": "biolink:Cell", "ic": 92.76600187037766, "identifiers": [{"i": "CL:0009084", "l": "glandular epithelial cell of endometrium", "d": ["An epithelial cell that is part of an endometrium glandular epithelium."], "t": []}], "preferred_name": "glandular epithelial cell of endometrium", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0000554", "l": "gastrin stimulating hormone secreting cell", "d": ["A peptide hormone secreting cell that secretes gastrin stimulating hormone."], "t": []}], "preferred_name": "gastrin stimulating hormone secreting cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0205869", "l": "Perivascular Oligodendroglia", "d": [], "t": []}], "preferred_name": "Perivascular Oligodendroglia", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1254547", "l": "Hypochromic erythrocyte", "d": [], "t": []}, {"i": "NCIT:C37033", "l": "Hypochromic Red Blood Cell", "d": [], "t": []}, {"i": "SNOMEDCT:397021001", "l": "", "d": [], "t": []}], "preferred_name": "Hypochromic erythrocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0002549", "l": "fibroblast of choroid plexus", "d": ["A fibroblast that is part of the choroid plexus."], "t": []}], "preferred_name": "fibroblast of choroid plexus", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1267869", "l": "Lymphocyte positive for both CD11C antigen and CD20 antigen", "d": [], "t": []}, {"i": "SNOMEDCT:116847007", "l": "", "d": [], "t": []}], "preferred_name": "Lymphocyte positive for both CD11C antigen and CD20 antigen", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5815568", "l": "Human allogeneic bone marrow derived osteoblastic cells", "d": [], "t": []}], "preferred_name": "Human allogeneic bone marrow derived osteoblastic cells", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0002313", "l": "endocrine-paracrine cell of prostate gland", "d": ["An ecto-epithelial cell of the prostate gland that secretes hormones."], "t": []}, {"i": "UMLS:C2323448", "l": "Endocrine-paracrine cell of prostatic gland", "d": [], "t": []}], "preferred_name": "endocrine-paracrine cell of prostate gland", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5206807", "l": "WT1/PRAME/Survivin-specific Cytotoxic T-lymphocytes", "d": [], "t": []}, {"i": "NCIT:C162764", "l": "WT1/PRAME/Survivin-specific Cytotoxic T-lymphocytes", "d": ["A preparation of  cytotoxic T-lymphocytes (CTLs) specifically reactive to the tumor-associated antigens (TAAs) human Wilms tumor protein (WT1), preferentially expressed antigen of melanoma (PRAME; melanoma antigen preferentially expressed in tumors; Opa-interacting protein 4; OIP-4), and survivin (baculoviral IAP repeat-containing protein 5; BIRC5), with potential immunomodulating and antineoplastic activities. Upon collection of peripheral blood mononuclear cells (PBMCs), these cells are stimulated with antigen presenting cells (APCs) pulsed with WT1, PRAME and survivin peptides; reactive T-cells are selectively expanded. Upon administration of the WT1/PRAME/Survivin-specific CTLs, these T-cells induce a CTL-mediated response against tumor cells expressing WT1, PRAME, or survivin, leading to tumor cell lysis and inhibition of tumor cell proliferation. WT1, PRAME, and survivin, are expressed on certain tumor cell types and play key roles in tumor cell proliferation and survival."], "t": []}], "preferred_name": "WT1/PRAME/Survivin-specific Cytotoxic T-lymphocytes", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0000927", "l": "CD4-positive type I NK T cell secreting interleukin-4", "d": ["A mature NK T cell that predominantly secretes type 2 cytokines such as interleukin-4 and interleukin-13 and enhances type 2 immune responses."], "t": []}], "preferred_name": "CD4-positive type I NK T cell secreting interleukin-4", "taxa": []}
{"type": "biolink:Cell", "ic": 73.98236851641934, "identifiers": [{"i": "CL:4023012", "l": "near-projecting glutamatergic cortical neuron", "d": ["A glutamatergic neuron located in the cerebral cortex that projects axons locally rather than distantly."], "t": []}], "preferred_name": "near-projecting glutamatergic cortical neuron", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5157524", "l": "CD3-CD45+ cells | Blood | Cell markers", "d": [], "t": []}], "preferred_name": "CD3-CD45+ cells | Blood | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0000241", "l": "stratified cuboidal epithelial cell", "d": ["A stratified epithelial cell that is part of cuboidal epithelium, characterized by multiple layers of cuboidal cells forming the apical layer. This provides a protective lining for ducts in large glands, such as sweat glands."], "t": []}], "preferred_name": "stratified cuboidal epithelial cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:2000054", "l": "hepatic pit cell", "d": ["A large, granular, liver specific natural killer cell that adheres to the endothelial cells of the hepatic sinusoid."], "t": []}], "preferred_name": "hepatic pit cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5784977", "l": "Autologous Anti-Claudin18.2 CAR T-cells LB1908", "d": [], "t": []}, {"i": "NCIT:C192206", "l": "Autologous Anti-Claudin18.2 CAR T-cells LB1908", "d": ["A preparation of autologous T-lymphocytes engineered to express a chimeric antigen receptor (CAR) specific for the tumor-associated antigen (TAA) Claudin18.2 (CLDN18.2; A2 isoform of claudin-18), with potential immunostimulating and antineoplastic activities. Upon administration, autologous anti-CLDN18.2 CAR T-cells LB1908 specifically recognize and induce selective toxicity in CLDN18.2-expressing tumor cells. CLDN18.2, a tight junction protein, is expressed on a variety of tumor cells, but its expression in healthy tissues is strictly confined to short-lived differentiated epithelial cells of the gastric mucosa."], "t": []}], "preferred_name": "Autologous Anti-Claudin18.2 CAR T-cells LB1908", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5909008", "l": "Pomlucabtagene Autoleucel", "d": [], "t": []}, {"i": "NCIT:C203125", "l": "Pomlucabtagene Autoleucel", "d": [], "t": []}], "preferred_name": "Pomlucabtagene Autoleucel", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0002056", "l": "fraction F mature B cell", "d": ["A mature B cell subset originally defined as having being CD45R-positive, IgM-positive, IgD-positive and CD43-negative. Subsequent research demonstrated being CD21-positive and CD23-negative and CD93 negative."], "t": []}], "preferred_name": "fraction F mature B cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0000985", "l": "IgG plasma cell", "d": ["A fully differentiated plasma cell that secretes IgG."], "t": []}], "preferred_name": "IgG plasma cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0596208", "l": "brain cell", "d": [], "t": []}], "preferred_name": "brain cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C3656576", "l": "CD158b+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:1372852009", "l": "", "d": [], "t": []}], "preferred_name": "CD158b+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1440262", "l": "Cell negative for CD16 antigen and positive for CD57 antigen", "d": [], "t": []}, {"i": "SNOMEDCT:1373167003", "l": "", "d": [], "t": []}], "preferred_name": "Cell negative for CD16 antigen and positive for CD57 antigen", "taxa": []}
{"type": "biolink:Cell", "ic": 84.21065366064373, "identifiers": [{"i": "CL:0002311", "l": "mammotroph", "d": ["An acidophilic cell of the anterior pituitary that produces prolactin."], "t": []}, {"i": "UMLS:C1517714", "l": "Lactotrophs", "d": [], "t": []}, {"i": "NCIT:C32911", "l": "Lactotroph Cell", "d": [], "t": []}, {"i": "MESH:D052682", "l": "Lactotrophs", "d": [], "t": []}, {"i": "SNOMEDCT:65357006", "l": "", "d": [], "t": []}], "preferred_name": "mammotroph", "taxa": []}
{"type": "biolink:Cell", "ic": 73.613037951824, "identifiers": [{"i": "CL:0000170", "l": "glucagon secreting cell", "d": ["A cell that secretes glucagon."], "t": []}, {"i": "UMLS:C0030280", "l": "Structure of alpha Cell of islet", "d": [], "t": []}, {"i": "NCIT:C32052", "l": "Alpha Cell", "d": ["A cell in the periphery of the pancreatic islets that secretes glucagon."], "t": []}, {"i": "MESH:D050416", "l": "Glucagon-Secreting Cells", "d": [], "t": []}, {"i": "SNOMEDCT:61028007", "l": "", "d": [], "t": []}], "preferred_name": "glucagon secreting cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5446633", "l": "Autologous Alpha-PNE Switchable CAR-T Cells CLBR001", "d": [], "t": []}, {"i": "NCIT:C175578", "l": "Autologous Alpha-PNE Switchable CAR-T Cells CLBR001", "d": ["A preparation of autologous T-lymphocytes that has been genetically engineered to express a switchable, alpha-peptide neo-epitope (PNE) chimeric antigen receptor (CAR) with a binding domain that can recognize a 14 aa peptide epitope, or PNE, of an antigen-specific adapter molecule, with potential immunomodulating and antineoplastic activities. Upon administration, autologous alpha-PNE switchable CAR-T (sCAR-T) cells CLBR001 remain inactivated. Upon administration of an antigen-specific adapter molecule, the binding domain of CLBR001 binds to the PNE of the adapter molecule, and CLBR001 is activated. This induces selective toxicity in and causes lysis of tumor cells expressing the specific antigen."], "t": []}], "preferred_name": "Autologous Alpha-PNE Switchable CAR-T Cells CLBR001", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C3641120", "l": "Plasmacytoid Dendritic Cell Vaccine", "d": [], "t": []}, {"i": "NCIT:C103192", "l": "Plasmacytoid Dendritic Cell Vaccine", "d": ["A whole cell vaccine derived from a distinct subset of dendritic cells (DCs) with a plasma cell-like morphology that exhibits immunomodulating activity. Plasmacytoid dendritic cells (pDCs) express a characteristic set of surface markers, such as CD123 (interleukin-3 receptor alpha chain), BDCA-2 (blood dendritic cell antigen 2; CD303) and BDCA-4 (CD304), as well as intracellular toll-like receptors 7 and 9. Upon stimulation, the activated pDCs produce substantial amounts of interferon (IFN) alpha, and to a lesser degree IFN-beta, as well as other cytokines and chemokines, such as tumor necrosis factor alpha and interleukins 1, 6 and 8. In addition, these pDCs, directly or indirectly stimulate T-cells, B-cells and natural killer cells. This may potentially lead to increased immunity against tumor cells."], "t": []}], "preferred_name": "Plasmacytoid Dendritic Cell Vaccine", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5557367", "l": "Allogeneic Human Stem Cell-derived Pancreatic Islet Cells VX-880", "d": [], "t": []}, {"i": "NCIT:C181923", "l": "Allogeneic Human Stem Cell-derived Pancreatic Islet Cells VX-880", "d": ["A preparation of allogeneic human stem cell-derived, fully differentiated functional pancreatic islet cells, that can be used for islet cell transplantation for the treatment of type 1 diabetes mellitus. Upon infusion into the hepatic portal vein, allogeneic human stem cell-derived pancreatic islet cells VX-880 may replace and restore pancreatic islet cells, which are destroyed in patients with type 1 diabetes. These cells may restore pancreatic islet cell function, produce insulin and may regulate blood glucose levels."], "t": []}], "preferred_name": "Allogeneic Human Stem Cell-derived Pancreatic Islet Cells VX-880", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1514760", "l": "Receptor Cell", "d": [], "t": []}, {"i": "NCIT:C13156", "l": "Receptor Cell", "d": ["Specialized cells located in sense organs that respond to physical and chemical stimuli by sending information to the central nervous system."], "t": []}], "preferred_name": "Receptor Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 69.61095963409787, "identifiers": [{"i": "CL:4030031", "l": "interstitial cell", "d": ["Any cell that is located within the interstitium between the cells most prominent in defining a given tissue. \"Interstitial cell\" is a morphological term and refers to a variety of cells with differing origins and phenotypes."], "t": []}, {"i": "UMLS:C1522406", "l": "interstitial cell", "d": [], "t": []}, {"i": "NCIT:C32870", "l": "Interstitial Cell", "d": ["An interstitial cell is a cell that is part of the connective and soft tissues."], "t": []}], "preferred_name": "interstitial cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0001280", "l": "Armed macrophage", "d": [], "t": []}, {"i": "SNOMEDCT:86373002", "l": "", "d": [], "t": []}], "preferred_name": "Armed macrophage", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C4086920", "l": "Tumor Peptide-loaded Myeloid Dendritic Cells", "d": [], "t": []}, {"i": "NCIT:C124055", "l": "Tumor Peptide-loaded Myeloid Dendritic Cells", "d": ["A cell-based cancer vaccine composed of myeloid dendritic cells (myDCs) pulsed with tumor peptides with potential immunostimulatory and antineoplastic activities. Upon administration, the tumor peptide-loaded myDCs stimulate a specific cytotoxic T-lymphocyte (CTL) response against the tumor cells, resulting in tumor cell lysis."], "t": []}], "preferred_name": "Tumor Peptide-loaded Myeloid Dendritic Cells", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1440257", "l": "CD14+HLA-DR+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:1373097008", "l": "", "d": [], "t": []}], "preferred_name": "CD14+HLA-DR+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5417820", "l": "Allogeneic CD8+ Leukemia-associated Antigens Specific T Cells NEXI-001", "d": [], "t": []}, {"i": "NCIT:C170887", "l": "Allogeneic CD8+ Leukemia-associated Antigens Specific T Cells NEXI-001", "d": ["A preparation of allogeneic CD8+ T cells targeting multiple undisclosed leukemia-associated antigens, with potential immunomodulating and antineoplastic activities. Following peripheral blood mononuclear cell (PBMC) collection from the original stem cell donor and ex vivo priming and expansion, the allogeneic CD8+ leukemia-associated antigens specific T cells NEXI-001 are re-introduced into the leukemia patient, where they target and kill tumor cells expressing these leukemia-associated antigens."], "t": []}], "preferred_name": "Allogeneic CD8+ Leukemia-associated Antigens Specific T Cells NEXI-001", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4079023", "l": "sacral dorsal root ganglion Nav1.9 neuron", "d": ["A nociceptor whose soma is located in the sacral dorsal root ganglion and that expresses the voltage-gated sodium channel Nav1.9 (encoded by SCN11A). This neuron is characterized by a persistent, tetrodotoxin-resistant sodium current that modulates resting membrane potential and amplifies subthreshold depolarizations, contributing to enhanced excitability during inflammation (Dib-Hajj et al. 2002, PMID:11972962). In human DRG, Nav1.9-immunoreactive neurons constitute approximately 26% of TrkA-positive neurons, a significantly higher proportion than the 12% observed in mouse (Rostock et al. 2018, PMID:29229553), suggesting species differences in inflammatory pain processing."], "t": []}], "preferred_name": "sacral dorsal root ganglion Nav1.9 neuron", "taxa": []}
{"type": "biolink:Cell", "ic": 92.76600187037766, "identifiers": [{"i": "CL:0002171", "l": "globose cell of olfactory epithelium", "d": ["A rounded or elliptical epithelial cell, with pale-staining open face nucleus and pale cytoplasm rich in free ribosomes and clusters of centrioles; form a distinct basal zone spaced slightly from the basal surface of the epithelium."], "t": []}, {"i": "UMLS:C1180330", "l": "Globose cell of olfactory epithelium", "d": [], "t": []}], "preferred_name": "globose cell of olfactory epithelium", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1268443", "l": "Normal cell", "d": [], "t": []}, {"i": "SNOMEDCT:118957004", "l": "", "d": [], "t": []}], "preferred_name": "Normal cell", "taxa": []}
{"type": "biolink:Cell", "ic": 78.80476858236055, "identifiers": [{"i": "CL:0000578", "l": "experimentally modified cell in vitro", "d": ["A cell in vitro that has undergone physical changes as a consequence of a deliberate and specific experimental procedure."], "t": []}], "preferred_name": "experimentally modified cell in vitro", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "CL:0002544", "l": "aortic endothelial cell", "d": ["An arterial endothelial cell that is part of the aorta endothelium."], "t": []}], "preferred_name": "aortic endothelial cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1440603", "l": "Erythrocytes.CD59 deficient", "d": [], "t": []}], "preferred_name": "Erythrocytes.CD59 deficient", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "CL:0000678", "l": "commissural neuron", "d": ["A neuron with soma location in the central nervous system that project its axon to the contralateral side of a central nervous system. This neuron can have its soma in the spinal cord, in the hemisphere of the brain, in the retina or in the ventral nerve cord of invertebrates."], "t": []}], "preferred_name": "commissural neuron", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5783946", "l": "Anti-DLL3 CAR-NK Cells", "d": [], "t": []}, {"i": "NCIT:C190818", "l": "Anti-DLL3 CAR-NK Cells", "d": ["A preparation of natural killer (NK) cells engineered to express a chimeric antigen receptor (CAR) specific for the tumor-associated antigen (TAA) delta-like protein 3 (DLL3), with potential immunomodulating and antineoplastic activities. Upon administration, the anti-DLL3 CAR-NK cells recognize, bind to and induce selective cytotoxicity in DLL3-expressing tumor cells. DLL3, a Notch pathway protein, is overexpressed on a variety of cancer cell types. It plays a key role in embryonic development and in tumor initiation and proliferation."], "t": []}], "preferred_name": "Anti-DLL3 CAR-NK Cells", "taxa": []}
{"type": "biolink:Cell", "ic": 88.20185721311867, "identifiers": [{"i": "CL:0002535", "l": "epithelial cell of cervix", "d": ["An epithelial cell of the cervix."], "t": []}], "preferred_name": "epithelial cell of cervix", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0009068", "l": "CD8aa(I) thymocyte", "d": ["An unconventional T lymphocyte population within the thymic medulla that is potentially a thymic resident population."], "t": []}], "preferred_name": "CD8aa(I) thymocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0000176", "l": "ecdysteroid secreting cell", "d": ["Any secretory cell that is capable of some ecdysteroid secretion."], "t": []}], "preferred_name": "ecdysteroid secreting cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5432253", "l": "Descartes-30", "d": [], "t": []}], "preferred_name": "Descartes-30", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5221031", "l": "Neutrophils|Urine/Urine sed", "d": [], "t": []}], "preferred_name": "Neutrophils|Urine/Urine sed", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1516095", "l": "Atypical Fibroblastic Spindle Cell", "d": [], "t": []}, {"i": "NCIT:C36956", "l": "Atypical Fibroblastic Spindle Cell", "d": [], "t": []}], "preferred_name": "Atypical Fibroblastic Spindle Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "CL:0002674", "l": "H minus", "d": ["A S. pombe mating type determined by the mat1-Mc and mat1-Mi on the mat1 locus."], "t": []}], "preferred_name": "H minus", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C3273204", "l": "MAGE-A3 Reactive T Cell Receptor-transduced Autologous T Cells", "d": [], "t": []}, {"i": "NCIT:C97035", "l": "MAGE-A3 Reactive T Cell Receptor-transduced Autologous T Cells", "d": ["Human autologous T-lymphocytes transduced with a retroviral vector encoding a T cell receptor (TCR) specific for the human melanoma antigen A3 (MAGE-A3), with potential antineoplastic activity. Upon isolation, transduction, expansion ex vivo, and reintroduction into the patient, the MAGE-A3 reactive TCR-transduced autologous T cells bind to tumor cells expressing MAGE-A3, which may halt the growth of MAGE-A3-expressing cancer cells; the TCR is specific for MAGE-A3:168-176."], "t": []}], "preferred_name": "MAGE-A3 Reactive T Cell Receptor-transduced Autologous T Cells", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1520105", "l": "Wisconsin H13 stem cell line", "d": [], "t": []}, {"i": "NCIT:C20311", "l": "WA13", "d": ["Provider: Wisconsin Alumni Research Foundation (WARF), Madison, WI. Information from provider and not independently verified by NIH: Cells are positive for cell markers SSEA-3, SSEA-4, TRA-1-60, TRA-1-81, and alkaline phosphatase; Cells are negative for SSEA-1; Give rise to teratomas containing derivatives of three germ layers in SCID mice; Differentiate in vitro; Cells not yet ready for distribution. Publication: Thomson et al., Science 282, 1145, 1998. This cell line meets the criteria for the use of human embryonic stem cells by federally funded researchers."], "t": []}], "preferred_name": "Wisconsin H13 stem cell line", "taxa": []}
{"type": "biolink:Cell", "ic": 83.11065783093733, "identifiers": [{"i": "CL:4300349", "l": "Purkinje layer interneuron (Mmus)", "d": ["A Purkinje layer interneuron of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Rgs6 (Mmus), Slc6a5 (Mmus), Shisa9 (Mmus), Zic1 (Mmus), Bmp6 (Mmus). Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Subclass:309 CB PLI Gly-Gaba."], "t": []}], "preferred_name": "Purkinje layer interneuron (Mmus)", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5157451", "l": "CD3+CD56+ cells | Tissue and Smears | Cell markers", "d": [], "t": []}], "preferred_name": "CD3+CD56+ cells | Tissue and Smears | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0483193", "l": "CD7+CD3-", "d": [], "t": []}], "preferred_name": "CD7+CD3-", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1515997", "l": "Anti-gp100 TCR Retroviral Vector-Transduced Autologous TIL", "d": [], "t": []}, {"i": "NCIT:C38135", "l": "Anti-gp100 TCR Retroviral Vector-Transduced Autologous TIL", "d": ["Human tumor infiltrating lymphocytes (TIL) isolated from a melanoma patient and were engineered to react with the melanoma antigen glycoprotein 100 (gp100). These TIL are transfected with a retroviral pGCsam vector encoding T-cell receptors specific for gp100, grown in culture, and then transferred back to the patient. These genetically modified TIL may recognize and halt the growth of gp100-expressing melanoma cells."], "t": []}], "preferred_name": "Anti-gp100 TCR Retroviral Vector-Transduced Autologous TIL", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0947288", "l": "CD71+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:116830006", "l": "", "d": [], "t": []}], "preferred_name": "CD71+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5555045", "l": "Prizloncabtagene autoleucel", "d": [], "t": []}], "preferred_name": "Prizloncabtagene autoleucel", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1440335", "l": "Cells.CD59 deficient", "d": [], "t": []}], "preferred_name": "Cells.CD59 deficient", "taxa": []}
{"type": "biolink:Cell", "ic": 92.76600187037766, "identifiers": [{"i": "UMLS:C1513999", "l": "Neoplastic Large Cell with Abundant Eosinophilic Cytoplasm", "d": [], "t": []}, {"i": "NCIT:C37106", "l": "Neoplastic Large Cell with Abundant Eosinophilic Cytoplasm", "d": [], "t": []}], "preferred_name": "Neoplastic Large Cell with Abundant Eosinophilic Cytoplasm", "taxa": []}
{"type": "biolink:Cell", "ic": 92.76600187037766, "identifiers": [{"i": "CL:1001131", "l": "vasa recta ascending limb cell", "d": ["A cell that is part of some vasa recta ascending limb."], "t": []}], "preferred_name": "vasa recta ascending limb cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C2983776", "l": "Allogeneic IL13-Zetakine/HyTK-Expressing-Glucocorticoid Resistant Cytotoxic T Lymphocytes GRm13Z40-2", "d": [], "t": []}, {"i": "NCIT:C90577", "l": "Allogeneic IL13-Zetakine/HyTK-Expressing-Glucocorticoid Resistant Cytotoxic T Lymphocytes GRm13Z40-2", "d": ["A preparation of glucocorticoid receptor (GR) negative, allogeneic cytotoxic T-lymphocytes (CTLs) expressing a membrane-tethered interleukin 13 (IL13) cytokine chimeric T-cell antigen receptor (zetakine), with potential antineoplastic activity. Upon transfection of donor T-lymphocytes with a plasmid encoding a fusion protein of the IL13-zetakine and the selection-suicide expression enzyme HyTK, these modified CTLs are expanded and introduced into a patient with glioblastoma multiforme (GBM). This agent specifically targets IL13 receptor alpha2, a glioma-restricted cell-surface epitope; the CTLs exert their cytolytic effect thereby killing IL13Ra2-expressing glioma cells. In addition, IL13-zetakine redirected CTLs induce production of certain cytokines. Furthermore, due to the fact that these CTLs are GR negative, they can be used concomitantly with glucocorticoid therapy. The IL13-zetakine consists of an extracellular IL-13 E13Y mutein-human IgG4 hinge-Fc chimera fused to human cytoplasmic CD3-zeta via the transmembrane domain of human CD4."], "t": []}], "preferred_name": "Allogeneic IL13-Zetakine/HyTK-Expressing-Glucocorticoid Resistant Cytotoxic T Lymphocytes GRm13Z40-2", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C2734107", "l": "Erythrocytes+Granulocytes.CD55+CD59 deficient", "d": [], "t": []}], "preferred_name": "Erythrocytes+Granulocytes.CD55+CD59 deficient", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1317634", "l": "Agranular platelet", "d": [], "t": []}, {"i": "SNOMEDCT:726588009", "l": "", "d": [], "t": []}], "preferred_name": "Agranular platelet", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C0333854", "l": "Large cleaved cell", "d": [], "t": []}, {"i": "NCIT:C32923", "l": "Large Cleaved Cell", "d": ["An activated lymphocyte with a diameter of about 12 micrometers, a nucleus with deep folds or clefts and clumped chromatin."], "t": []}, {"i": "SNOMEDCT:72549000", "l": "", "d": [], "t": []}], "preferred_name": "Large cleaved cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C2709137", "l": "Frozen packed erythrocytes", "d": [], "t": []}], "preferred_name": "Frozen packed erythrocytes", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C4725100", "l": "Autologous CD22-4SCAR-expressing T-cells 4SCAR22", "d": [], "t": []}, {"i": "NCIT:C148524", "l": "Autologous CD22-4SCAR-expressing T-cells 4SCAR22", "d": ["A preparation of genetically modified autologous T-cells transduced with a replication incompetent, self-inactivating lentiviral vector expressing a  fourth generation chimeric antigen receptor (4SCAR) consisting of an anti-CD22 single chain variable fragment (scFv) that is coupled to the costimulatory signaling domains CD28, CD137, CD27 and the zeta chain of the T-cell receptor (TCR), and is fused with the suicide gene inducible caspase 9 (iCasp9), with potential immunostimulating and antineoplastic activities. Upon intravenous administration, autologous CD22-4SCAR-expressing T-cells 4SCAR22 are directed to and induce selective toxicity in CD22-expressing tumor cells. iCasp9 consists of a human FK506 drug-binding domain with an F36V mutation (FKBP12-F36V) linked to human caspase 9. If the administered T-cells lead to unacceptable side effects, the chemical homodimerizer AP1903 can be administered. AP1903 binds to the drug binding FKBP12-F36V domain and induces activation of caspase 9, which results in the apoptosis of the administered T-cells and enhances safety of this agent. CD22, a B-lineage-restricted, transmembrane phosphoglycoprotein, is expressed on malignant B cells. CD28, CD137 and CD27, T-cell surface-associated co-stimulatory molecules, are required for full T-cell activation and enhance both proliferation of T-cells and antitumor activity."], "t": []}], "preferred_name": "Autologous CD22-4SCAR-expressing T-cells 4SCAR22", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C4525866", "l": "Autologous MAGE-A3/A6-specific TCR Gene-engineered Lymphocytes KITE-718", "d": [], "t": []}, {"i": "NCIT:C135534", "l": "Autologous MAGE-A3/A6-specific TCR Gene-engineered Lymphocytes KITE-718", "d": ["Human autologous T-lymphocytes genetically modified to express a T-cell receptor (TCR) that specifically targets human melanoma-associated antigen A3 (MAGE-A3) and MAGE-A6 (MAGEA3/A6; MAGE-A3/A6), with potential antineoplastic activity. Peripheral blood mononuclear cells (PBMCs) are isolated from a patient, transduced with a gene expressing a TCR specific for the MAGE-A3/A6 antigens, expanded ex vivo, and reintroduced into the patient. Then, the autologous MAGE-A3/A6-specific TCR gene engineered lymphocytes KITE-718 target and bind to tumor cells expressing the MAGE-A3 and/or MAGE-A6 antigens. This halts the growth of and kills MAGE-A3/A6-expressing cancer cells. The tumor-associated antigens MAGE-A3 and MAGE-A6 are overexpressed on a variety of tumor cell types."], "t": []}], "preferred_name": "Autologous MAGE-A3/A6-specific TCR Gene-engineered Lymphocytes KITE-718", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1511185", "l": "Bizarre Neoplastic Stromal Giant Cell", "d": [], "t": []}, {"i": "NCIT:C36826", "l": "Bizarre Neoplastic Stromal Giant Cell", "d": [], "t": []}], "preferred_name": "Bizarre Neoplastic Stromal Giant Cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0225667", "l": "Dense-core granulated cell", "d": [], "t": []}, {"i": "SNOMEDCT:85615000", "l": "", "d": [], "t": []}], "preferred_name": "Dense-core granulated cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0882892", "l": "CD5+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:116746008", "l": "", "d": [], "t": []}], "preferred_name": "CD5+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5216306", "l": "Plasma cells|NCnc|Pt|Bld", "d": [], "t": []}], "preferred_name": "Plasma cells|NCnc|Pt|Bld", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:1000719", "l": "kidney inner medulla collecting duct intercalated cell", "d": ["Any renal intercalated cell that is part of some inner medullary collecting duct."], "t": []}], "preferred_name": "kidney inner medulla collecting duct intercalated cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5986114", "l": "Human Embryonic Stem Cell-derived Midbrain Dopamine Neuron Cells MSK-DA01", "d": [], "t": []}], "preferred_name": "Human Embryonic Stem Cell-derived Midbrain Dopamine Neuron Cells MSK-DA01", "taxa": []}
{"type": "biolink:Cell", "ic": 85.53200374075534, "identifiers": [{"i": "CL:0000240", "l": "stratified squamous epithelial cell", "d": ["A stratified epithelial cell that is part of squamous epithelium, characterized by multiple layers of cells. The basal layer is directly attached to the basement membrane and the apical layer consists of flattened squamous cells. This provides a protective barrier, commonly found in areas subject to abrasion, such as the skin, oral cavity, and esophagus."], "t": []}], "preferred_name": "stratified squamous epithelial cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1440391", "l": "IgG+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:1373080002", "l": "", "d": [], "t": []}], "preferred_name": "IgG+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": 83.11065783093733, "identifiers": [{"i": "CL:0002193", "l": "myelocyte", "d": ["A cell type that is the first of the maturation stages of the granulocytic leukocytes normally found in the bone marrow. Granules are seen in the cytoplasm. The nuclear material of the myelocyte is denser than that of the myeloblast but lacks a definable membrane. The cell is flat and contains increasing numbers of granules as maturation progresses."], "t": []}], "preferred_name": "myelocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 92.76600187037766, "identifiers": [{"i": "UMLS:C1517725", "l": "Neoplastic Large Erythroblast", "d": [], "t": []}, {"i": "NCIT:C37059", "l": "Neoplastic Large Erythroblast", "d": [], "t": []}], "preferred_name": "Neoplastic Large Erythroblast", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0000902", "l": "induced T-regulatory cell", "d": ["CD4-positive alpha-beta T cell with the phenotype CD25-positive, CTLA-4-positive, and FoxP3-positive with regulatory function."], "t": []}], "preferred_name": "induced T-regulatory cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5163719", "l": "Erythrocytes | Gastric fluid | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Erythrocytes | Gastric fluid | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0546501", "l": "P.B. promegakaryocyte", "d": [], "t": []}], "preferred_name": "P.B. promegakaryocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0002239", "l": "ooblast", "d": ["A primordial cell from which an oocyte (ovum) ultimately is developed."], "t": []}, {"i": "UMLS:C0683191", "l": "Ooblast", "d": [], "t": []}], "preferred_name": "ooblast", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:3000001", "l": "Hofbauer cell", "d": ["A tissue-resident macrophage that is part of the placenta. A Hofbauer cell expresses high levels of growth factors and metalloproteinases that support vasculogenesis, angiogenesis, branching morphogenesis and tissue remodeling. A Hofbauer cell has a fetal origin, is found in the villous stroma, chorion, and amnion, and is present throughout pregnancy."], "t": []}], "preferred_name": "Hofbauer cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C3830403", "l": "Donor Regulatory T-lymphocytes", "d": [], "t": []}, {"i": "NCIT:C111894", "l": "Donor Regulatory T-lymphocytes", "d": ["Donor-derived regulatory T-cells (Tregs), with potential immunomodulating activity.  Tregs are a subset of CD4+ T cells that express high levels of CD25 (interleukin 2 receptor) and the transcription factor Foxp3. The donor CD4+CD25+ Tregs modulate immune responses and may induce tolerance to allogeneic organ transplants, such as hematopoietic stem cell transplants (HSCTs), thereby preventing graft-versus-host disease (GVHD)."], "t": []}], "preferred_name": "Donor Regulatory T-lymphocytes", "taxa": []}
{"type": "biolink:Cell", "ic": 92.76600187037766, "identifiers": [{"i": "CL:0002017", "l": "Kit-negative, Ly-76 high orthochromatophilic erythroblasts", "d": ["An orthochromatophilic erythroblast that is ter119-high, CD71-low, and Kit-negative."], "t": []}], "preferred_name": "Kit-negative, Ly-76 high orthochromatophilic erythroblasts", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5690232", "l": "Leukocytes | Amniotic fluid | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Leukocytes | Amniotic fluid | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C0023172", "l": "Lupus erythematosus cell", "d": [], "t": []}, {"i": "NCIT:C36716", "l": "LE Cell", "d": ["The lupus erythematosus cell, which is likely a neutrophil with denatured nuclei. It may be found in blood, bone marrow, synovial fluid, cerebrospinal fluid, pericardial and pleural effusions of individuals with lupus erythematosus."], "t": []}, {"i": "SNOMEDCT:7055007", "l": "", "d": [], "t": []}], "preferred_name": "Lupus erythematosus cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:1000411", "l": "endothelial cell of Peyer's patch", "d": ["An endothelial cell that is part of the small intestine Peyer's patch."], "t": []}, {"i": "UMLS:C1180239", "l": "Endothelial cell of Peyer's patch", "d": [], "t": []}], "preferred_name": "endothelial cell of Peyer's patch", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0004232", "l": "starburst amacrine cell", "d": ["An amacrine cell with a flat dendritic arbor and a medium dendritic field. Starburst amacrine cells have post-synaptic terminals in S2. This cell type releases the neurotransmitters gamma-aminobutyric acid (GABA) and acetylcholine."], "t": []}], "preferred_name": "starburst amacrine cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5707550", "l": "Donor TCR Alpha/Beta/CD19-depleted Mononuclear Cell-enriched Activated Natural Killer Cells", "d": [], "t": []}, {"i": "NCIT:C188056", "l": "Donor TCR Alpha/Beta/CD19-depleted Mononuclear Cell-enriched Activated Natural Killer Cells", "d": ["A preparation of donor-derived, haploidentical, cytokine-activated natural killer (NK) cells enriched with mononuclear cells from haploidentical donor that have been depleted of T-cell receptor (TCR) alpha and beta (TCRa/b+) as well as CD19-positive (CD19+) cells, that may potentially be used for immune reconstitution purposes. Upon administration, the donor TCR alpha/beta/CD19-depleted mononuclear cell-enriched activated NK cells may enhance immune reconstitution. The depletion of alpha/beta T-cells, which are implicated in the adaptive immune response that mediates graft-versus-host disease (GvHD), may promote rapid and sustained engraftment, immune reconstitution, and may prevent or reduce the development of GvHD. The depletion of CD19+ B-cells may reduce the risk of Epstein-Barr virus (EBV)-driven post-transplant lymphoproliferative disorders."], "t": []}], "preferred_name": "Donor TCR Alpha/Beta/CD19-depleted Mononuclear Cell-enriched Activated Natural Killer Cells", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5690100", "l": "CD4+CD154+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:1373105008", "l": "", "d": [], "t": []}], "preferred_name": "CD4+CD154+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C4745144", "l": "Autologous CD4+/CD8+ EGFR806 Specific 4-1BB-CD3zeta-EGFRt-expressing CAR T Cells", "d": [], "t": []}, {"i": "NCIT:C156883", "l": "Autologous CD4+/CD8+ EGFR806 Specific 4-1BB-CD3zeta-EGFRt-expressing CAR T Cells", "d": ["A preparation of CD4+ and CD8+ autologous T-lymphocytes transduced with a lentiviral vector expressing a chimeric antigen receptor (CAR) composed of a short chain variable fragment (scFv) binding domain derived from depatuxizumab, a human anti-epidermal growth factor receptor (EGFR) monoclonal antibody (MAb806; ABT-806), coupled to the zeta chain of the TCR/CD3 complex (CD3-zeta) and the signaling domain of 4-1BB (CD137),  and linked to a truncated form of the human epidermal growth factor receptor (EGFRt), with potential immunostimulating and antineoplastic activities. Depatuxizumab specifically targets abnormal conformational states of EGFR, including the EGFR deletion mutation variant III (EGFRvIII), and activating mutations, with very low affinity for wild-type EGFR. Upon intravenous administration, the autologous CD4+/CD8+ EGFR806 specific 4-1BB-CD3zeta-EGFRt-expressing CAR T-cells are directed to and induce selective toxicity in EGFRvIII-expressing tumor cells. Devoid of both ligand binding domains and tyrosine kinase activity, the expressed EGFRt both facilitates in vivo detection of the administered, transduced T-cells and can promote elimination of these cells through an anti-EGFR antibody-dependent cellular cytotoxicity (ADCC) response. EGFRvIII, an in-frame deletion of exons 2-7 in the EGFR gene, is overexpressed by a variety of cancer cell types but absent in normal, healthy cells. It plays a key role in tumor cell proliferation, tumor angiogenesis and resistance to both radio- and chemotherapy."], "t": []}], "preferred_name": "Autologous CD4+/CD8+ EGFR806 Specific 4-1BB-CD3zeta-EGFRt-expressing CAR T Cells", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5157358", "l": "CD19+CD38+IgM+ cells | Blood | Cell markers", "d": [], "t": []}], "preferred_name": "CD19+CD38+IgM+ cells | Blood | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0002645", "l": "endo-epithelial cell of pharyngotympanic part of viscerocranial mucosa", "d": ["An endocranial viscerocranial mucosa cell that is part of viscerocranial mucosa."], "t": []}, {"i": "UMLS:C1182668", "l": "Endo-epithelial cell of pharyngotympanic part of viscerocranial mucosa", "d": [], "t": []}], "preferred_name": "endo-epithelial cell of pharyngotympanic part of viscerocranial mucosa", "taxa": []}
{"type": "biolink:Cell", "ic": 92.76600187037766, "identifiers": [{"i": "CL:7770004", "l": "suprabasal cell", "d": ["An epithelial cell that resides in the layer(s) immediately above the basal layer in stratified or pseudostratified epithelia. This cell mainly originates from basal cells and is found across various tissues, including skin, esophagus, oral mucosa, airway, and cornea."], "t": []}], "preferred_name": "suprabasal cell", "taxa": []}
{"type": "biolink:Cell", "ic": 85.53200374075534, "identifiers": [{"i": "UMLS:C1518184", "l": "Malignant Thyroid Gland Oncocyte", "d": [], "t": []}, {"i": "NCIT:C37097", "l": "Malignant Thyroid Gland Oncocyte", "d": [], "t": []}], "preferred_name": "Malignant Thyroid Gland Oncocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 88.20185721311867, "identifiers": [{"i": "CL:4301603", "l": "Tanycyte NN_2 tanycyte (Mmus)", "d": ["A tanycyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Gpr50 (Mmus), Ccdc170 (Mmus), Nkx2-4 (Mmus). Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Supertype:1173 Tanycyte NN_2."], "t": []}], "preferred_name": "Tanycyte NN_2 tanycyte (Mmus)", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4033141", "l": "submandibular ganglion TH cholinergic neuron", "d": ["A parasympathetic neuron that has the soma located in the submandibular ganglion and expresses the marker tyrosine hydroxylase (TH)."], "t": []}], "preferred_name": "submandibular ganglion TH cholinergic neuron", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5170472", "l": "Large unstained cells | Blood | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Large unstained cells | Blood | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": 79.07356789860069, "identifiers": [{"i": "UMLS:C1882043", "l": "Neoplastic Apocrine Cell", "d": [], "t": []}, {"i": "NCIT:C62494", "l": "Neoplastic Apocrine Cell", "d": [], "t": []}], "preferred_name": "Neoplastic Apocrine Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 92.76600187037766, "identifiers": [{"i": "UMLS:C1882060", "l": "Neoplastic Small Epithelial Cell with Scant Amount of Cytoplasm", "d": [], "t": []}, {"i": "NCIT:C61296", "l": "Neoplastic Small Epithelial Cell with Scant Amount of Cytoplasm", "d": [], "t": []}], "preferred_name": "Neoplastic Small Epithelial Cell with Scant Amount of Cytoplasm", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5159803", "l": "Chronic leukemia markers | XXX | Cell markers", "d": [], "t": []}], "preferred_name": "Chronic leukemia markers | XXX | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0933802", "l": "Smooth columnar cell", "d": [], "t": []}], "preferred_name": "Smooth columnar cell", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "UMLS:C5960363", "l": "Neoplastic Cell with Clear Cytoplasm", "d": [], "t": []}, {"i": "NCIT:C207449", "l": "Neoplastic Cell with Clear Cytoplasm", "d": ["A neoplastic cell with an abundant amount of clear cytoplasm."], "t": []}], "preferred_name": "Neoplastic Cell with Clear Cytoplasm", "taxa": []}
{"type": "biolink:Cell", "ic": 58.46326060791124, "identifiers": [{"i": "UMLS:C1514115", "l": "Neoplastic Transitional Cell", "d": [], "t": []}, {"i": "NCIT:C36768", "l": "Neoplastic Transitional Cell", "d": [], "t": []}], "preferred_name": "Neoplastic Transitional Cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1440371", "l": "CD95+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:1372945006", "l": "", "d": [], "t": []}], "preferred_name": "CD95+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5401601", "l": "Human Embryonic Stem Cell-derived M Cell", "d": [], "t": []}], "preferred_name": "Human Embryonic Stem Cell-derived M Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 72.0250656653823, "identifiers": [{"i": "UMLS:C1517659", "l": "Keratinizing Malignant Squamous Cell", "d": [], "t": []}, {"i": "NCIT:C36791", "l": "Keratinizing Malignant Squamous Cell", "d": ["A malignant squamous cell which produces extracellular keratin."], "t": []}], "preferred_name": "Keratinizing Malignant Squamous Cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1267970", "l": "Lymphocyte positive for CD79A antigen", "d": [], "t": []}, {"i": "SNOMEDCT:117410007", "l": "", "d": [], "t": []}], "preferred_name": "Lymphocyte positive for CD79A antigen", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5157497", "l": "CD34+CD117+ blasts | Blood | Cell markers", "d": [], "t": []}], "preferred_name": "CD34+CD117+ blasts | Blood | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": 83.11065783093733, "identifiers": [{"i": "UMLS:C1710151", "l": "Spindle B Melanoma Cell", "d": [], "t": []}, {"i": "NCIT:C54159", "l": "Spindle B Melanoma Cell", "d": [], "t": []}], "preferred_name": "Spindle B Melanoma Cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4696000", "l": "CD3+CD4+CD27-CD45RO+CD62L- cell", "d": [], "t": []}, {"i": "SNOMEDCT:1373246007", "l": "", "d": [], "t": []}], "preferred_name": "CD3+CD4+CD27-CD45RO+CD62L- cell", "taxa": []}
{"type": "biolink:Cell", "ic": 87.18682603146104, "identifiers": [{"i": "UMLS:C1513172", "l": "Metaplastic Epithelial Cell", "d": [], "t": []}, {"i": "NCIT:C36816", "l": "Metaplastic Epithelial Cell", "d": [], "t": []}], "preferred_name": "Metaplastic Epithelial Cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C3489668", "l": "Neoplastic Colony-Forming Units", "d": [], "t": []}], "preferred_name": "Neoplastic Colony-Forming Units", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C4086000", "l": "Autologous Anti-CD19 CAR-expressing T Lymphocytes", "d": [], "t": []}, {"i": "NCIT:C125691", "l": "Autologous Anti-CD19 CAR-expressing T Lymphocytes", "d": ["A preparation of autologous T-lymphocytes that have been genetically modified to express a chimeric antigen receptor (CAR) that targets the human tumor associated antigen (TAA) CD19, with potential immunostimulating and antineoplastic activities. Upon administration, autologous anti-CD19 CAR-expressing T lymphocytes bind to and induce selective toxicity against CD19-expressing tumor cells. CD19 antigen is a B-cell specific cell surface antigen expressed in all B-cell lineage malignancies."], "t": []}], "preferred_name": "Autologous Anti-CD19 CAR-expressing T Lymphocytes", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5157615", "l": "CD55+CD59 deficient RBC+Granulocytes | Blood | Cell markers", "d": [], "t": []}], "preferred_name": "CD55+CD59 deficient RBC+Granulocytes | Blood | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C2736932", "l": "Cell positive for CD3 antigen and positive for CD45 antigen (cell)", "d": [], "t": []}, {"i": "SNOMEDCT:1373010009", "l": "", "d": [], "t": []}], "preferred_name": "Cell positive for CD3 antigen and positive for CD45 antigen (cell)", "taxa": []}
{"type": "biolink:Cell", "ic": 89.40238429118027, "identifiers": [{"i": "CL:4301615", "l": "olfactory ensheathing cell (Mmus)", "d": ["A olfactory ensheathing cell of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Apod (Mmus), Npy (Mmus). Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Supertype:1185 OEC NN_1."], "t": []}], "preferred_name": "olfactory ensheathing cell (Mmus)", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5962498", "l": "Autologous NKG2D CAR-expressing T-lymphocytes ASP2802", "d": [], "t": []}, {"i": "NCIT:C209764", "l": "Autologous NKG2D CAR-expressing T-lymphocytes ASP2802", "d": ["A preparation of autologous T-lymphocytes that are genetically modified to express a chimeric antigen receptor (CAR) for a modified and inactivated form of the type II transmembrane protein human natural-killer group 2, member D receptor protein (NKG2D; KLRK1), that can be used for potential immunostimulating and antineoplastic activities upon activation in vivo. Upon infusion back into the patient, autologous NKG2D CAR-expressing T-lymphocytes ASP2802 are inert. Upon subsequent administration of MA-20 (ASP101G; MicAbody), a bispecific adaptor molecule composed of an anti-CD20 antibody linked to a UL16-binding protein (ULBP) 2 ligand, the anti-CD20 antibody moiety of MA-20 targets and binds to CD20-expressing tumor cells and the ULBP2 ligand targets and binds to the NKG2D CAR moiety of the convertible CAR T-cells ASP2802, thereby activating the inactivated CAR T-cells, which induce selective toxicity in and lysis of CD20-expressing tumor cells. The CD20 antigen, a non-glycosylated cell surface phosphoprotein, is a B-cell specific cell surface antigen expressed in B-cell lineage malignancies."], "t": []}], "preferred_name": "Autologous NKG2D CAR-expressing T-lymphocytes ASP2802", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C2963388", "l": "Bizarre platelets", "d": [], "t": []}], "preferred_name": "Bizarre platelets", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "CL:1000312", "l": "bronchial goblet cell", "d": ["A goblet cell that is part of the epithelium of bronchus."], "t": []}, {"i": "UMLS:C2326430", "l": "Bronchial goblet cell", "d": [], "t": []}], "preferred_name": "bronchial goblet cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5157518", "l": "CD3-CD16+ cells | Tissue and Smears | Cell markers", "d": [], "t": []}], "preferred_name": "CD3-CD16+ cells | Tissue and Smears | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5687323", "l": "Population of all neutrophilic myelocytes in portion of fluid", "d": [], "t": []}, {"i": "SNOMEDCT:1208769003", "l": "", "d": [], "t": []}], "preferred_name": "Population of all neutrophilic myelocytes in portion of fluid", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4307105", "l": "MOL NN_4 Spock3 mature myelinating oligodendrocyte (Mmus)", "d": ["A mature myelinating oligodendrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Cldn11 (Mmus), A230001M10Rik (Mmus), Spock3 (Mmus), Rhoj (Mmus). It is distinguished from other MOL NN_4 cells by expression of Spock3, Rhoj. These cells are located in the Midbrain, Isocortex, brain . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5285 MOL NN_4."], "t": []}], "preferred_name": "MOL NN_4 Spock3 mature myelinating oligodendrocyte (Mmus)", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1440238", "l": "CD106+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:725718007", "l": "", "d": [], "t": []}], "preferred_name": "CD106+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": 90.871710685482, "identifiers": [{"i": "CL:1001436", "l": "hair-tylotrich neuron", "d": ["The subcutaneous mechanoreceptors that innervate tylotrich hair follicles."], "t": []}], "preferred_name": "hair-tylotrich neuron", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5380989", "l": "Cells.CD8.HLA-B7 CMV specific.CMV antigen stimulated CD107a+b expressing", "d": [], "t": []}], "preferred_name": "Cells.CD8.HLA-B7 CMV specific.CMV antigen stimulated CD107a+b expressing", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C3275034", "l": "CNDO-109", "d": [], "t": []}, {"i": "NCIT:C99898", "l": "CNDO-109-activated Allogeneic Natural Killer Cells", "d": ["A preparation of non-interleukin-2 primed, tumor activated allogeneic natural killer (NK) cells with potential immunostimulating activity. The allogeneic NK cells obtained from a first or second degree relative of the patient are co-incubated with a lysate from the CTV-1 cell line, a minimally differentiated myeloid line derived from an acute myelogenous leukemia patient. Infusion of CNDO-109-activated allogeneic NK cells may be able to lyse and destroy NK-resistant tumor cells and a broad spectrum of tumor cells."], "t": []}], "preferred_name": "CNDO-109", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0000903", "l": "natural T-regulatory cell", "d": ["CD4-positive alpha-beta T cell with the phenotype FoxP3-positive, CD25-positive, CD62L-positive, and CTLA-4 positive with regulatory function."], "t": []}], "preferred_name": "natural T-regulatory cell", "taxa": []}
{"type": "biolink:Cell", "ic": 76.40371442623734, "identifiers": [{"i": "CL:1001318", "l": "renal interstitial pericyte", "d": ["A pericyte cell located in the kidney interstitium."], "t": []}], "preferred_name": "renal interstitial pericyte", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "CL:0002336", "l": "buccal mucosa cell", "d": ["An endothelial cell that lines the oral cavitiy including the mucosa of the gums, the palate, the lip, and the cheek."], "t": []}], "preferred_name": "buccal mucosa cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5560983", "l": "", "d": [], "t": []}], "preferred_name": "", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C2350249", "l": "Hemogenic Endothelial Cells", "d": [], "t": []}], "preferred_name": "Hemogenic Endothelial Cells", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C4725690", "l": "Autologous Anti-CD19 CAR-T Cells TBI-1501", "d": [], "t": []}, {"i": "NCIT:C150377", "l": "Autologous Anti-CD19 CAR-T Cells TBI-1501", "d": ["Autologous T-lymphocytes that have been transduced, via a proprietary technology involving a recombinant human fibronectin fragment to enhance transduction efficiency, with a retroviral vector to express a chimeric antigen receptor (CAR) consisting of a single chain variable fragment (scFv) of anti-CD19 coupled to co-stimulatory molecules, with potential immunostimulating and antineoplastic activities. Upon transfusion, anti-CD19-CAR-expressing autologous T-lymphocytes TBI-1501 target and bind to CD19-expressing neoplastic B-cells. This results in a cytotoxic T-lymphocyte (CTL) response against CD19-expressing tumor cells, the release of cytotoxic molecules and the induction of tumor cell lysis. CD19, cluster of differentiation 19, is a B-cell-specific cell surface antigen overexpressed in B-cell lineage tumors. Incorporation of the costimulatory signaling domains increase proliferation and activation of T-cells."], "t": []}], "preferred_name": "Autologous Anti-CD19 CAR-T Cells TBI-1501", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0020040", "l": "calcified zone articular chondrocyte", "d": ["An articular chondrocyte located in the calcified cartilage zone below the tidemark at the interface between articular cartilage and subchondral bone, embedded within a mineralized extracellular matrix. In humans, this cell exhibits a hypertrophic-like phenotype and typically expresses collagen type X (COL10A1). Together with the surrounding calcified matrix, it forms a transitional region that mechanically couples the deep articular cartilage to the underlying subchondral bone."], "t": []}], "preferred_name": "calcified zone articular chondrocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 79.07356789860069, "identifiers": [{"i": "UMLS:C1519449", "l": "Spermatogenic Cell", "d": [], "t": []}, {"i": "NCIT:C33582", "l": "Spermatogenic Cell", "d": ["A cell that produces sperm."], "t": []}], "preferred_name": "Spermatogenic Cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5690765", "l": "Limbal Stem Cells", "d": [], "t": []}, {"i": "MESH:D000093282", "l": "Limbal Stem Cells", "d": [], "t": []}], "preferred_name": "Limbal Stem Cells", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5157484", "l": "CD33 blasts | Bone marrow | Cell markers", "d": [], "t": []}], "preferred_name": "CD33 blasts | Bone marrow | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5961055", "l": "Autologous CD5KO Anti-CD5 CAR 4-1BB-expressing T-lymphocytes and Autologous CD5KO T-lymphocytes", "d": [], "t": []}, {"i": "NCIT:C208227", "l": "Autologous CD5KO Anti-CD5 CAR 4-1BB-expressing T-lymphocytes and Autologous CD5KO T-lymphocytes", "d": ["A dual-population preparation of autologous T-lymphocytes in which the tumor-associated antigen (TAA) CD5 is knocked out (CD5KO) and is genetically modified to express a chimeric antigen receptor (CAR) specific for CD5 and coupled to the co-stimulatory molecule 4-1BB (CD137), and autologous CD5KO normal untransduced T-lymphocytes, with potential immunomodulating and antineoplastic activities. Upon administration of autologous CD5KO anti-CD5 CAR 4-1BB-expressing T-lymphocytes and autologous CD5KO T-lymphocytes, the autologous CD5KO anti-CD5 CAR 4-1BB-expressing T-lymphocytes specifically recognize and kill CD5-expressing tumor cells. CD5 is a T-cell surface glycoprotein expressed on the surface of normal T-cells and overexpressed on various B- and T-cell malignancies. CD5 KO in the CART5 cells prevents CART fratricide and enhances CAR-T cell function. The CD5KO normal T-cells allow for T-cell reconstitution and may mitigate T-cell toxicity."], "t": []}], "preferred_name": "Autologous CD5KO Anti-CD5 CAR 4-1BB-expressing T-lymphocytes and Autologous CD5KO T-lymphocytes", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C2930257", "l": "Autologous cultured chondrocyte", "d": [], "t": []}, {"i": "SNOMEDCT:840610002", "l": "", "d": [], "t": []}], "preferred_name": "Autologous cultured chondrocyte", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0242697", "l": "Muscle Fibers", "d": [], "t": []}], "preferred_name": "Muscle Fibers", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0000435", "l": "alkali secreting cell", "d": [], "t": []}], "preferred_name": "alkali secreting cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0598828", "l": "granule cell (connective tissue)", "d": [], "t": []}], "preferred_name": "granule cell (connective tissue)", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C2709134", "l": "Frozen erythrocytes newborn units", "d": [], "t": []}], "preferred_name": "Frozen erythrocytes newborn units", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C4085984", "l": "Anti-Programmed Cell Death Protein 1 Antibody Expressing Pluripotent Killer T-Lymphocytes", "d": [], "t": []}, {"i": "NCIT:C125654", "l": "Anti-Programmed Cell Death Protein 1 Antibody Expressing Pluripotent Killer T-Lymphocytes", "d": ["A specific population of pluripotent killer (PIK) T-cells that have been induced to express high levels of antibodies against the negative immunoregulatory human cell surface receptor programmed cell death protein 1 (PD-1; PDCD1; CD279), with potential antitumor activity. Although the exact mechanism(s) of action through which PIK-PD-1 cells exert their effects has yet to be elucidated, upon infusion, these cells secrete antibodies that target PD-1 expressed on the surface of activated T-cells and tumor cells. This may block the interaction of PD-1 with its ligands, programmed cell death 1 ligand 1 (PD-L1, PD-1L1; CD274) and PD-1 ligand 2 (PD-L2, PD-1L2; CD273). The inhibition of ligand binding prevents PD-1-mediated signaling and results in both T-cell activation and the induction of T-cell-mediated immune responses against tumor cells. PD-1, an immunoglobulin (Ig) superfamily transmembrane protein and inhibitory receptor, negatively regulates T-cell activation; PD-L1 is overexpressed on certain cancer cells, and PD-L2 is primarily expressed on antigen presenting cells (APCs)."], "t": []}], "preferred_name": "Anti-Programmed Cell Death Protein 1 Antibody Expressing Pluripotent Killer T-Lymphocytes", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5907972", "l": "iPSC-derived Anti-CD19 CAR/CD16/IL-15RF/ADR-expressing CD38-eliminated NK Cells FT522", "d": [], "t": []}, {"i": "NCIT:C202279", "l": "iPSC-derived Anti-CD19 CAR/CD16/IL-15RF/ADR-expressing CD38-eliminated NK Cells FT522", "d": ["An allogeneic, off-the-shelf, natural killer (NK) cell product derived from a clonal master induced pluripotent stem cell (iPSC) line, and engineered and multiplex-edited to express a chimeric antigen receptor (CAR) specific for the tumor-associated antigen (TAA) CD19, a high-affinity, non-cleavable CD16 (hnCD16) Fc receptor, a recombinant fusion of IL-15 and IL-15 receptor alpha (IL-15RF), an alloimmune defense receptor (ADR) that targets the immune co-stimulatory receptor 4-1BB (CD137; tumor necrosis factor receptor superfamily member 9; TNFRSF9), and to eliminate CD38 expression, with potential immunostimulatory and antineoplastic activities. Upon administration, iPSC-derived anti-CD19 CAR/CD16/IL-15RF/ADR-expressing CD38-eliminated NK cells FT522 recognize, bind to and induce selective cytotoxicity in CD19-expressing tumor cells, leading to tumor cell lysis and the release of tumor neoantigens. Additionally, FT522 NK cells secrete inflammatory cytokines and chemokines, thereby enhancing T-cell activity and recruitment to the tumor site. CD19 antigen is a B-cell specific cell surface antigen expressed in all B-cell lineage malignancies. IL-15RF promotes the survival of NK cells and enhances the cytotoxic effect of the NK cells and the activated anti-tumor T-cells. The ADR targets 4-1BB-expressing alloreactive immune cells and leads to the killing of the alloreactive immune cells, further enhancing potency and extending the persistence of the FT522 NK cells. When used in combination with monoclonal antibodies, the hnCD16 Fc receptor of FT522 binds to the Fc portion of tumor cell-bound monoclonal antibodies, leading to NK cell activation, cytokine secretion and enhanced antibody-dependent cellular cytotoxicity (ADCC). CD16, also known as Fc-gamma receptor III, is normally expressed on the surface of NK cells, neutrophils, monocytes and macrophages, and plays a key role in initiating ADCC. It is often downregulated in certain cancers, thereby inhibiting the anti-tumor immune response. The lack of CD38 in FT522 NK cells prevents NK cell fratricide upon co-administration with a CD38-targeting monoclonal antibody as CD38 is normally expressed on the surface of activated NK cells. This enhances ADCC mediated by CD38-targeting monoclonal antibodies."], "t": []}], "preferred_name": "iPSC-derived Anti-CD19 CAR/CD16/IL-15RF/ADR-expressing CD38-eliminated NK Cells FT522", "taxa": []}
{"type": "biolink:Cell", "ic": 72.21593899684457, "identifiers": [{"i": "CL:0000050", "l": "megakaryocyte-erythroid progenitor cell", "d": ["A progenitor cell committed to the megakaryocyte and erythroid lineages."], "t": []}, {"i": "UMLS:C2350244", "l": "Megakaryocyte-Erythroid Progenitor Cells", "d": [], "t": []}, {"i": "MESH:D055015", "l": "Megakaryocyte-Erythroid Progenitor Cells", "d": [], "t": []}], "preferred_name": "megakaryocyte-erythroid progenitor cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4047040", "l": "smooth muscle circular layer cell", "d": ["A smooth muscle cell that is found in the inner muscular layer of hollow organs. It is characterized by its spiral/helical arrangement around organ lumens. This cell is crucial for peristaltic movements in organs."], "t": []}], "preferred_name": "smooth muscle circular layer cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C3900005", "l": "Autologous Anti-HPV-16 E6 T-cell Receptor Gene-engineered Peripheral Blood Lymphocytes", "d": [], "t": []}, {"i": "NCIT:C118850", "l": "Autologous Anti-HPV-16 E6 T-cell Receptor Gene-engineered Peripheral Blood Lymphocytes", "d": ["Human autologous peripheral blood lymphocytes (PBLs) transduced with a retroviral vector encoding a T cell receptor (TCR) that is specifically directed against the viral oncoprotein human papillomavirus type 16 (HPV-16) E6, with potential antineoplastic activity. Upon isolation, transduction, expansion ex vivo, and reintroduction into the patient, the autologous anti-HPV-16 E6 TCR gene-engineered PBLs bind to HPV-16 E6-expressing tumor cells. This may result in a specific cytotoxic T-lymphocyte (CTL)-mediated killing of HPV-16 E6-positive cancer cells. HPV-16 E6, a cell surface glycoprotein, is overexpressed by a variety of HPV-associated cancers and is absent from healthy human tissues."], "t": []}], "preferred_name": "Autologous Anti-HPV-16 E6 T-cell Receptor Gene-engineered Peripheral Blood Lymphocytes", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:1000714", "l": "kidney cortex collecting duct principal cell", "d": ["Any renal principal cell that is part of some cortical collecting duct."], "t": []}], "preferred_name": "kidney cortex collecting duct principal cell", "taxa": []}
{"type": "biolink:Cell", "ic": 92.76600187037766, "identifiers": [{"i": "CL:0011104", "l": "interplexiform cell", "d": ["A type of interneuron in the retinal inner nuclear layer which\ncarries information from the inner plexiform layer and the outer\nplexiform layer."], "t": []}], "preferred_name": "interplexiform cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C4288532", "l": "PDCD-1 Knockout Autologous T-lymphocytes", "d": [], "t": []}, {"i": "NCIT:C128281", "l": "PDCD-1 Knockout Autologous T-lymphocytes", "d": ["A population of engineered autologous T-lymphocytes in which the gene encoding for the programmed cell death protein 1 (PDCD-1) is deleted, with potential immunomodulating activity. Following collection of peripheral blood lymphocytes and selection of T-cells, the PDCD-1 gene was knocked out and the T-cells were expanded. Upon reinfusion of the PDCD-1 knockout T-lymphocytes, these T-cells target and lyse cancer cells. The PDCD-1 protein, found on activated T-cells and often overexpressed on T-cells in cancer patients, negatively regulates T-cell activity; it plays a key role in immune evasion and prevents tumor cell lysis. PDCD-1 knockout enhances cytotoxicity and T-cell-mediated anti-tumor immune responses."], "t": []}], "preferred_name": "PDCD-1 Knockout Autologous T-lymphocytes", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0000756", "l": "type 4 cone bipolar cell (sensu Mus)", "d": ["An OFF-bipolar neuron found in the retina and having connections with cone photoreceptors cells and neurons in the outer half of the inner plexiform layer. The cell has a diffuse axon terminal with varicosities in sublaminae 1 and 2 of the inner plexiform layer."], "t": []}], "preferred_name": "type 4 cone bipolar cell (sensu Mus)", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5667111", "l": "Autologous mbIL-12-expressing Tumor Infiltrating Lymphocytes GT202", "d": [], "t": []}, {"i": "NCIT:C187050", "l": "Autologous mbIL-12-expressing Tumor Infiltrating Lymphocytes GT202", "d": ["A preparation of autologous tumor infiltrating lymphocytes (TILs) engineered to express membrane-bound interleukin-12 (mbIL-12), with potential immunomodulating and antineoplastic activities. The TILs are isolated from an autologous tumor sample and engineered to express mbIL-12. Upon infusion of the autologous mbIL-12-expressing TILs GT202 back into the patient, the cells specifically recognize, target and kill the patient's tumor cells. IL-12 expression activates the immune system by promoting the secretion of interferon-gamma (IFNg), activating natural killer cells (NKs), and inducing cytotoxic T-lymphocyte (CTL) responses, further killing tumor cells."], "t": []}], "preferred_name": "Autologous mbIL-12-expressing Tumor Infiltrating Lymphocytes GT202", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5853654", "l": "NVD-001", "d": [], "t": []}], "preferred_name": "NVD-001", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4033098", "l": "inner wall Schlemm's canal endothelial cell", "d": ["A Schlemm's canal endothelial cell that lines the inner wall of the Schlemm's canal. This cell exhibits a cobblestone appearance due to the significant biomechanical load it experiences, as well as the segmental flow of aqueous humor. The degree of biomechanical stress can lead to the formation of dome-like outpouchings known as giant vacuoles. In addition, the cell contains transcellular pores that mediate aqueous humor transport (Dautriche et al., 2015). This endothelial cell also displays prominent peripheral F-actin bands which help maintain structural integrity under pressure (Ethier et al., 2004)."], "t": []}], "preferred_name": "inner wall Schlemm's canal endothelial cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C4744703", "l": "Autologous Anti-BCMA-CAR-TCRz/4-1BB-expressing T-lymphocytes CART-BCMA", "d": [], "t": []}, {"i": "NCIT:C156272", "l": "Autologous Anti-BCMA-CAR-TCRz/4-1BB-expressing T-lymphocytes CART-BCMA", "d": ["A preparation of autologous T-lymphocytes that have been ex vivo transduced with a genetically-engineered lentiviral vector (LV) expressing a chimeric antigen receptor (CAR) containing an extracellular human single chain variable fragment (scFv) specific for the tumor-associated antigen (TAA) human B-cell maturation antigen (BCMA; tumor necrosis factor receptor superfamily member 17; TNFRSF17) fused to an intracellular tandem signaling domain comprised of the co-stimulatory domain of 4-1BB (CD137) and the zeta chain of the T-cell receptor (TCR)/CD3 complex (CD3z), with potential immunostimulating and antineoplastic activities. Upon administration, autologous anti-BCMA-CAR-4-1BB-CD3zeta-expressing T-lymphocytes specifically recognize and induce selective toxicity in BCMA-expressing tumor cells. BCMA, a tumor-specific antigen and a receptor for both a proliferation-inducing ligand (APRIL) and B-cell activating factor (BAFF), is a member of the tumor necrosis factor receptor superfamily (TNFRSF) and plays a key role in plasma cell survival. BCMA is found on the surfaces of plasma cells and overexpressed on malignant plasma cells."], "t": []}], "preferred_name": "Autologous Anti-BCMA-CAR-TCRz/4-1BB-expressing T-lymphocytes CART-BCMA", "taxa": []}
{"type": "biolink:Cell", "ic": 55.500185543973835, "identifiers": [{"i": "CL:0000039", "l": "germ line cell", "d": ["A cell that is within the developmental lineage of gametes and is able to pass along its genetic material to offspring."], "t": []}], "preferred_name": "germ line cell", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "CL:0009095", "l": "endothelial cell of uterus", "d": ["An endothelial cell that is part of a uterus."], "t": []}], "preferred_name": "endothelial cell of uterus", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5222944", "l": "CD3- CD16+ cells/100 cells in blood", "d": [], "t": []}], "preferred_name": "CD3- CD16+ cells/100 cells in blood", "taxa": []}
{"type": "biolink:Cell", "ic": 78.54651317367835, "identifiers": [{"i": "CL:0002068", "l": "Purkinje myocyte", "d": ["Specialized cardiac myocyte that is subendocardially interspersed with the regular cardiac muscle cell. They are uninucleate cylindrical cells, associated end-to-end in long rows, continue from the node to the atrioventricular bundle; relatively short compared to ordinary myocytes but are nearly twice their diameter."], "t": []}, {"i": "UMLS:C1178808", "l": "Purkinje myocyte", "d": [], "t": []}], "preferred_name": "Purkinje myocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 90.871710685482, "identifiers": [{"i": "CL:0001056", "l": "dendritic cell, human", "d": ["A dendritic cell with the phenotype HLA-DRA-positive."], "t": []}], "preferred_name": "dendritic cell, human", "taxa": []}
{"type": "biolink:Cell", "ic": 88.20185721311867, "identifiers": [{"i": "CL:0001030", "l": "CD117-positive common myeloid progenitor OR CD217-positive common lymphoid progenitor", "d": [], "t": []}], "preferred_name": "CD117-positive common myeloid progenitor OR CD217-positive common lymphoid progenitor", "taxa": []}
{"type": "biolink:Cell", "ic": 49.01884648268335, "identifiers": [{"i": "CL:0000197", "l": "sensory receptor cell", "d": ["A cell that is capable of detection of a stimulus involved in sensory perception."], "t": []}], "preferred_name": "sensory receptor cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C2986401", "l": "GITRL RNA-transfected Autologous Dendritic Cell Vaccine", "d": [], "t": []}, {"i": "NCIT:C94216", "l": "GITRL RNA-transfected Autologous Dendritic Cell Vaccine", "d": ["An autologous dendritic cell (DC) cancer vaccine with potential immunostimulatory activity. GITRL RNA-transfected autologous DC vaccine is prepared by transfecting DCs with RNAs encoding tumor necrosis factor (ligand) superfamily, member 18 (TNFSF18 or GlTRL); expression of GlTRL results in modulating T lymphocyte survival in peripheral tissues. Co-vaccination of this vaccine with melanoma antigen specific vaccine may eliminate the adverse effects associated with systemic administration of immune modulators, while also enhancing vaccine-induced immune responses."], "t": []}], "preferred_name": "GITRL RNA-transfected Autologous Dendritic Cell Vaccine", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C4725102", "l": "Autologous CD123-4SCAR-expressing T-cells 4SCAR123", "d": [], "t": []}, {"i": "NCIT:C148526", "l": "Autologous CD123-4SCAR-expressing T-cells 4SCAR123", "d": ["A preparation of genetically modified autologous T-cells transduced with a replication incompetent, self-inactivating lentiviral vector expressing a  fourth generation chimeric antigen receptor (4SCAR) consisting of an anti-CD123 (interleukin-3 receptor alpha chain or IL3RA) single chain variable fragment (scFv) that is coupled to the costimulatory signaling domains CD28, CD137, CD27 and the zeta chain of the T-cell receptor (TCR), and is fused with the suicide gene inducible caspase 9 (iCasp9), with potential immunostimulating and antineoplastic activities. Upon administration, autologous CD123-4SCAR-expressing T-cells 4SCAR123 are directed to and induce selective toxicity in CD123-expressing tumor cells. iCasp9 consists of a human FK506 drug-binding domain with an F36V mutation (FKBP12-F36V) linked to human caspase 9. If the administered T-cells lead to unacceptable side effects, the chemical homodimerizer AP1903 can be administered. AP1903 binds to the drug binding FKBP12-F36V domain and induces activation of caspase 9, which results in the apoptosis of the administered T-cells and enhances safety of this agent. CD123 is normally expressed on committed blood progenitor cells in the bone marrow; its overexpression is associated with increased leukemic cell proliferation and aggressiveness. CD28, CD137 and CD27, T-cell surface-associated co-stimulatory molecules, are required for full T-cell activation and enhance both proliferation of T-cells and antitumor activity."], "t": []}], "preferred_name": "Autologous CD123-4SCAR-expressing T-cells 4SCAR123", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5986146", "l": "INKmune (TM)", "d": [], "t": []}], "preferred_name": "INKmune (TM)", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5980663", "l": "Cells.CD3+CD4+|Bld (LG51997-1)", "d": [], "t": []}], "preferred_name": "Cells.CD3+CD4+|Bld (LG51997-1)", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5216314", "l": "Prolymphocytes|NCnc|Pt|Bld", "d": [], "t": []}], "preferred_name": "Prolymphocytes|NCnc|Pt|Bld", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0002502", "l": "type M enteroendocrine cell", "d": ["An enteroendocrine cell of the small intestine that secretes motilin."], "t": []}, {"i": "UMLS:C2332053", "l": "Type Mo enteroendocrine cell", "d": [], "t": []}], "preferred_name": "type M enteroendocrine cell", "taxa": []}
{"type": "biolink:Cell", "ic": 92.76600187037766, "identifiers": [{"i": "UMLS:C0024156", "l": "Luteal Cells", "d": [], "t": []}, {"i": "NCIT:C12610", "l": "Lutein Cell", "d": ["A cell located in the corpus luteum of the ovary that is derived from theca or granulosa cells and secretes progesterone and estrogen or androgens."], "t": []}, {"i": "MESH:D008184", "l": "Luteal Cells", "d": [], "t": []}], "preferred_name": "Luteal Cells", "taxa": []}
{"type": "biolink:Cell", "ic": 78.80476858236055, "identifiers": [{"i": "CL:0000178", "l": "Leydig cell", "d": ["A Leydig cell is a testosterone-secreting cell in the interstitial area, between the seminiferous tubules, in the testis."], "t": []}, {"i": "UMLS:C0023602", "l": "Structure of interstitial cell of Leydig", "d": [], "t": []}, {"i": "NCIT:C12609", "l": "Leydig Cell", "d": ["Testosterone-secreting interstitial cells located between the seminiferous tubules of the testes."], "t": []}, {"i": "MESH:D007985", "l": "Leydig Cells", "d": [], "t": []}, {"i": "SNOMEDCT:44185004", "l": "", "d": [], "t": []}], "preferred_name": "Leydig cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4033117", "l": "cervicothoracic ganglion VAChT neuron", "d": ["A sympathetic neuron that has the soma located in the cervicothoracic ganglion and expresses the marker vesicular acetylcholine transporter (VAChT)."], "t": []}], "preferred_name": "cervicothoracic ganglion VAChT neuron", "taxa": []}
{"type": "biolink:Cell", "ic": 89.40238429118027, "identifiers": [{"i": "CL:0000642", "l": "folliculostellate cell", "d": ["An agranular supporting cell of the anterior pituitary (adenohypophysis) that is characterized by a star-like morphology and ability to form follicles. Folliculostellate cells communicate with each other and with endocrine cells via gap junctions."], "t": []}], "preferred_name": "folliculostellate cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5212794", "l": "Chromosome 12 copy number", "d": [], "t": []}], "preferred_name": "Chromosome 12 copy number", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0333798", "l": "Poikilocyte (cell)", "d": [], "t": []}, {"i": "SNOMEDCT:397020000", "l": "", "d": [], "t": []}], "preferred_name": "Poikilocyte (cell)", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0000102", "l": "polymodal neuron", "d": ["A neuron type that respond to multiple stimuli such as mechanical, thermal and chemical. This neuron type is responsible for integrating different types of sensory inputs, allowing organisms to respond appropriately to diverse environmental challenges."], "t": []}], "preferred_name": "polymodal neuron", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5171961", "l": "Malignant cells | Cerebral spinal fluid | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Malignant cells | Cerebral spinal fluid | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C4763825", "l": "Autologous Anti-PSCA-CAR-4-1BB/TCRzeta-CD19t-expressing T-lymphocytes", "d": [], "t": []}, {"i": "NCIT:C157746", "l": "Autologous Anti-PSCA-CAR-4-1BB/TCRzeta-CD19t-expressing T-lymphocytes", "d": ["A preparation of autologous T-lymphocytes that have been immunomagnetically depleted of CD14+ myeloid cells and CD25+ regulatory T-cells (Tregs), activated with anti-CD3 and anti-CD28 beads, and transduced with a self-inactivating (SIN) lentiviral vector (LV) encoding a chimeric antigen receptor (CAR) containing a prostate stem cell antigen (PSCA)-specific, humanized and affinity matured A11 single chain variable fragment (scFv), a human immunoglobulin G4 (IgG4) Fc spacer lacking the CH2 domain, a human CD4 transmembrane domain, a costimulatory human 4-1BB (CD137) cytoplasmic signaling domain linked to the zeta chain of the human T-cell receptor (TCR)/CD3 complex (CD3zeta), and a truncated human CD19 sequence (CD19t), with potential immunostimulating and antineoplastic activities. Upon intravenous infusion, the autologous anti-PSCA-CAR-4-1BB/TCRzeta-CD19t-expressing T-lymphocytes recognize and induce selective toxicity in PSCA-expressing tumor cells. PSCA, a glycosyl-phosphatidylinositol (GPI)-linked cell surface antigen, is uniquely and highly expressed in certain cancers including bladder, pancreatic, and prostate cancers. Co-expression of CD19t provides an inert, non-immunogenic surface marker that allows for measurement of genetically modified cells and tracking of T-cells following adoptive transfer. The costimulatory signaling domains improve T-cell function, selectivity, expansion and survival."], "t": []}], "preferred_name": "Autologous Anti-PSCA-CAR-4-1BB/TCRzeta-CD19t-expressing T-lymphocytes", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C6021870", "l": "Cells.CD4.Interleukin 10 expressing", "d": [], "t": []}], "preferred_name": "Cells.CD4.Interleukin 10 expressing", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1440366", "l": "CD9+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:1372941002", "l": "", "d": [], "t": []}], "preferred_name": "CD9+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "CL:0002024", "l": "Kit-positive megakaryocyte progenitor cell", "d": ["A megakaryocyte progenitor cell that is Kit-positive, CD41-positive, CD9-positive, Sca-1-negative, IL7ralpha-negative, CD150-negative, and Fcgamma receptor II/III-low."], "t": []}], "preferred_name": "Kit-positive megakaryocyte progenitor cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5157421", "l": "CD3 blasts | Bone marrow | Cell markers", "d": [], "t": []}], "preferred_name": "CD3 blasts | Bone marrow | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5157403", "l": "CD23+CD38+ cells | Blood | Cell markers", "d": [], "t": []}], "preferred_name": "CD23+CD38+ cells | Blood | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": 90.871710685482, "identifiers": [{"i": "UMLS:C1516899", "l": "Eosinophilic Brown Fat Cell", "d": [], "t": []}, {"i": "NCIT:C36969", "l": "Eosinophilic Brown Fat Cell", "d": [], "t": []}], "preferred_name": "Eosinophilic Brown Fat Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1514438", "l": "Primitive Mesenchymal Stellate Cell", "d": [], "t": []}, {"i": "NCIT:C36928", "l": "Primitive Mesenchymal Stellate Cell", "d": [], "t": []}], "preferred_name": "Primitive Mesenchymal Stellate Cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0882831", "l": "CD3+CD26+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:1373006006", "l": "", "d": [], "t": []}], "preferred_name": "CD3+CD26+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4033026", "l": "lung perichondrial fibroblast", "d": ["A perichondrial fibroblast that is part of the lung."], "t": []}], "preferred_name": "lung perichondrial fibroblast", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C2830065", "l": "Romyelocel-L", "d": [], "t": []}], "preferred_name": "Romyelocel-L", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5205632", "l": "Adipose-derived Expanded Mesenchymal Stem Cells SCM-010", "d": [], "t": []}, {"i": "NCIT:C160891", "l": "Adipose-derived Expanded Mesenchymal Stem Cells SCM-010", "d": ["A preparation of human adipose-derived mesenchymal stem cells (MSCs), that can potentially be used for engraftment purposes in certain autoimmune disorders. Upon intrathecal administration, adipose-derived expanded mesenchymal stem cells SCM-010 migrate to the bone marrow. These MSCs are pluripotent and capable of differentiating along specific lineages and may activate the immune system and repair damage to the nervous system."], "t": []}], "preferred_name": "Adipose-derived Expanded Mesenchymal Stem Cells SCM-010", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "UMLS:C1711353", "l": "Malignant Large Hyperchromatic Fibrohistiocytic Cell", "d": [], "t": []}, {"i": "NCIT:C49074", "l": "Malignant Large Hyperchromatic Fibrohistiocytic Cell", "d": [], "t": []}], "preferred_name": "Malignant Large Hyperchromatic Fibrohistiocytic Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 75.70995031940328, "identifiers": [{"i": "CL:4023015", "l": "sncg GABAergic interneuron", "d": ["A transcriptomically distinct GABAergic neuron located in the cerebral cortex that expresses Gamma-synuclein.", "A transcriptomically distinct GABAergic neuron located in the cerebral cortex that expresses Gamma-synuclein. The standard transcriptomic reference data for this cell type can be found on the CellxGene census under the collection: 'Transcriptomic cytoarchitecture reveals principles of human neocortex organization', dataset: 'Supercluster: CGE-derived interneurons', Author Categories: 'CrossArea_subclass', clusters Sncg."], "t": []}], "preferred_name": "sncg GABAergic interneuron", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4322674", "l": "CD8+CD56+ NK lymphocyte", "d": [], "t": []}], "preferred_name": "CD8+CD56+ NK lymphocyte", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5416838", "l": "Autologous Non-Hematopoietic Peripheral Blood Stem Cells", "d": [], "t": []}], "preferred_name": "Autologous Non-Hematopoietic Peripheral Blood Stem Cells", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C4726557", "l": "Autologous CISH-inactivated TILs", "d": [], "t": []}, {"i": "NCIT:C151926", "l": "Autologous CISH-inactivated TILs", "d": ["A preparation of autologous tumor-infiltrating lymphocytes (TILs) where the cytokine-inducible SH2-containing protein gene (CISH) has been inactivated using the clustered regularly interspaced short palindromic repeat (CRISPR)/CRISPR associated protein 9 (Cas9) editing system, containing guide RNA (gRNA) coupled to a recombinant form of the DNA endonuclease Cas9, with potential immunomodulating and antineoplastic activities. Using the CRISPR/Cas9 system, the autologous TILs are transfected, ex vivo, with a plasmid encoding for a gRNA that site-specifically targets and binds to the human CISH gene. Cas9 cleaves these specific DNA sites, which causes double strand breaks, disrupts the gene encoding CISH and prevents transcription. Upon intravenous administration, the autologous CISH-inactivated TILs are able to induce a T-cell-mediated immune response against tumor cells. CISH, a member of the suppressor of cytokine signaling family (SOCS; cytokine-induced STAT inhibitor; STAT-induced STAT inhibitor; SSI), is induced by T-cell receptor (TCR) stimulation. CISH plays a key role in the negative regulation of both T-cell signaling and CTL-mediated tumor cell eradication. The knockout of the CISH gene enhances the expansion and anti-tumor activities of effector T-cells."], "t": []}], "preferred_name": "Autologous CISH-inactivated TILs", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "CL:2000000", "l": "epidermal melanocyte", "d": ["Any melanocyte that is part of a epidermis."], "t": []}], "preferred_name": "epidermal melanocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "UMLS:C5204267", "l": "Renomedullary Interstitial Cell", "d": [], "t": []}, {"i": "NCIT:C159218", "l": "Renomedullary Interstitial Cell", "d": ["A cell located in the inner renal medulla. It expresses receptors for vasoactive peptides."], "t": []}], "preferred_name": "Renomedullary Interstitial Cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4510905", "l": "Blast cell positive for CD16 antigen", "d": [], "t": []}, {"i": "SNOMEDCT:724250006", "l": "", "d": [], "t": []}], "preferred_name": "Blast cell positive for CD16 antigen", "taxa": []}
{"type": "biolink:Cell", "ic": 81.34422831136257, "identifiers": [{"i": "CL:0000718", "l": "compound eye cone cell", "d": ["A cell of an ommatidium that secretes lens materials."], "t": []}], "preferred_name": "compound eye cone cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4068503", "l": "FISH probe target locus", "d": [], "t": []}], "preferred_name": "FISH probe target locus", "taxa": []}
{"type": "biolink:Cell", "ic": 92.76600187037766, "identifiers": [{"i": "CL:1000306", "l": "fibroblast of tunica adventitia of artery", "d": ["A fibroblast that is part of the tunica adventitia of artery."], "t": []}, {"i": "UMLS:C2335260", "l": "Fibroblast of tunica adventitia of artery", "d": [], "t": []}], "preferred_name": "fibroblast of tunica adventitia of artery", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1656735", "l": "CD9+CD41+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:1373071002", "l": "", "d": [], "t": []}], "preferred_name": "CD9+CD41+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": 89.40238429118027, "identifiers": [{"i": "CL:0002198", "l": "oncocyte", "d": ["A large epithelial cell with an extremely acidophilic and granular cytoplasm, containing vast numbers of mitochondria; such cells may undergo neoplastic transformation. From the Greek word onkos meaning swelling, this cell type is found in parathyroid, salivary and thyroid glands."], "t": []}], "preferred_name": "oncocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1514167", "l": "Pleomorphic B-Lymphocyte", "d": [], "t": []}, {"i": "NCIT:C36996", "l": "Pleomorphic B-Lymphocyte", "d": [], "t": []}], "preferred_name": "Pleomorphic B-Lymphocyte", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0301864", "l": "Target cell of immunologic reaction", "d": [], "t": []}, {"i": "SNOMEDCT:56709009", "l": "", "d": [], "t": []}], "preferred_name": "Target cell of immunologic reaction", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5983821", "l": "Allogeneic Anti-CD19 CAR Double-negative T Cells RJMty19", "d": [], "t": []}, {"i": "NCIT:C212073", "l": "Allogeneic Anti-CD19 CAR Double-negative T Cells RJMty19", "d": ["An off-the-shelf (OTS) cell preparation composed of healthy, donor-derived CD4 and CD8 double-negative T-lymphocytes (DNTs) that are transduced with a lentiviral vector expressing a humanized chimeric antigen receptor (CAR) targeting the human tumor-associated antigen (TAA) CD19, with potential immunomodulating and antineoplastic activities. Upon administration, the allogeneic anti-CD19 CAR DNTs RJMty19 specifically targets and binds to tumor cells expressing CD19. This induces selective toxicity in tumor cells that express CD19. CD19 is a B-cell-specific cell surface antigen overexpressed in B-cell lineage malignancies. The DNTs contain a high proportion of stem cell-like memory T cells (Tscm)."], "t": []}], "preferred_name": "Allogeneic Anti-CD19 CAR Double-negative T Cells RJMty19", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1440272", "l": "CD11c+CD22+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:1372996008", "l": "", "d": [], "t": []}], "preferred_name": "CD11c+CD22+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5886264", "l": "Cells.chromosome region 20q12", "d": [], "t": []}], "preferred_name": "Cells.chromosome region 20q12", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5174861", "l": "Nonhematic cells | Cerebral spinal fluid | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Nonhematic cells | Cerebral spinal fluid | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5708807", "l": "Sphere Vitreous Seed", "d": [], "t": []}, {"i": "NCIT:C189883", "l": "Sphere Vitreous Seed", "d": ["A histopathologic classification of vitreous seeding that is characterized by spherically shaped clusters of tumor cells."], "t": []}], "preferred_name": "Sphere Vitreous Seed", "taxa": []}
{"type": "biolink:Cell", "ic": 92.76600187037766, "identifiers": [{"i": "CL:0001000", "l": "CD8-alpha-positive CD11b-negative dendritic cell", "d": ["CD8-alpha-positive CD11b-negative dendritic cell is a conventional dendritic cell that is CD11b-negative, CD4-negative and is CD205-positive and CD8-alpha-positive."], "t": []}], "preferred_name": "CD8-alpha-positive CD11b-negative dendritic cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5216200", "l": "Eosinophils|NCnc|Pt|Body fld", "d": [], "t": []}], "preferred_name": "Eosinophils|NCnc|Pt|Body fld", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5540530", "l": "keratinocytes, fibroblasts, collagen-dsat", "d": [], "t": []}], "preferred_name": "keratinocytes, fibroblasts, collagen-dsat", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5706388", "l": "Autologous Anti-CD5 CAR Monocytes MT-101", "d": [], "t": []}, {"i": "NCIT:C187269", "l": "Autologous Anti-CD5 CAR Monocytes MT-101", "d": ["A preparation of autologous monocytes genetically modified with mRNA technology to express a chimeric antigen receptor (CAR) specific for CD5, with potential immunomodulating and antineoplastic activities. Upon administration, the autologous anti-CD5 CAR monocytes MT-101 specifically recognize and bind to CD5-expressing tumor cells, and expose the immune system to the CD5 glycoprotein. This may elicit a cytotoxic T-lymphocyte (CTL) response against CD5-expressing tumor cells. CD5 is a T-cell surface glycoprotein expressed on the surface of normal T-cells and overexpressed on various B- and T-cell malignancies."], "t": []}], "preferred_name": "Autologous Anti-CD5 CAR Monocytes MT-101", "taxa": []}
{"type": "biolink:Cell", "ic": 89.40238429118027, "identifiers": [{"i": "CL:0000579", "l": "border follicle cell", "d": ["A follicle cell that migrates from the anterior pole of the insect egg chamber to the anterior of the oocyte where they participate in the formation of the micropyle."], "t": []}], "preferred_name": "border follicle cell", "taxa": []}
{"type": "biolink:Cell", "ic": 70.51821968886674, "identifiers": [{"i": "CL:0002522", "l": "renal filtration cell", "d": ["A renal filtration cell is a specialized cell of the renal system that filter fluids by charge, size or both."], "t": []}], "preferred_name": "renal filtration cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5216232", "l": "Leukocytes|NCnc|Pt|Body fld", "d": [], "t": []}], "preferred_name": "Leukocytes|NCnc|Pt|Body fld", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0020053", "l": "spiny Dogiel type I neuron of myenteric plexus", "d": ["A Dogiel type I neuron of the myenteric plexus characterised by spiny (spine-like) dendrite morphology with numerous short projections along the dendrites. This neuron is immunopositive for neuronal nitric oxide synthase (NOS1) and immunonegative for choline acetyltransferase (ChAT), corresponding to inhibitory motor neurons of the enteric nervous system."], "t": []}], "preferred_name": "spiny Dogiel type I neuron of myenteric plexus", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5419548", "l": "Modified Conditionally Reprogrammed Cells", "d": [], "t": []}, {"i": "NCIT:C172258", "l": "Modified Conditionally Reprogrammed Cells", "d": ["A conditionally reprogrammed cell sample comprised of non-epithelial cells isolated from a tissue sample that were rapidly expanded in monolayer culture under various cell type-specific culture conditions to promote the rapid proliferation of the cell type of interest."], "t": []}], "preferred_name": "Modified Conditionally Reprogrammed Cells", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5961181", "l": "Autologous Anti-CD3/Anti-EGFR Bispecific Antibody Armed Peripheral Blood Mononuclear Cells", "d": [], "t": []}, {"i": "NCIT:C208368", "l": "Autologous Anti-CD3/Anti-EGFR Bispecific Antibody Armed Peripheral Blood Mononuclear Cells", "d": ["A preparation of autologous peripheral blood mononuclear cells (PBMCs) in which T-lymphocytes are coated with a bispecific antibody directed against the tumor-associated antigen (TAA) human epidermal growth factor receptor (EGFR; HER1; ErbB1) and the T-cell surface antigen CD3 and activated ex vivo, with potential immunomodulating and antineoplastic activities. Upon reintroduction into the patient, the autologous anti-CD3/anti-EGFR bispecific antibody armed PBMCs target, bind to and selectively cross-link CD3-expressing T-cells and EGFR-expressing tumor cells. This results in the activation of cytotoxic T-lymphocytes (CTLs) and selective cytotoxicity towards the EGFR-expressing tumor cells. EGFR, a receptor tyrosine kinase, is overexpressed on the surfaces of various tumor cell types."], "t": []}], "preferred_name": "Autologous Anti-CD3/Anti-EGFR Bispecific Antibody Armed Peripheral Blood Mononuclear Cells", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1267887", "l": "CD19+SMIG KAPPA+ lymphocyte", "d": [], "t": []}, {"i": "SNOMEDCT:117563001", "l": "", "d": [], "t": []}], "preferred_name": "CD19+SMIG KAPPA+ lymphocyte", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5170936", "l": "Leukocytes | Prostatic fluid | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Leukocytes | Prostatic fluid | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5833375", "l": "Cells.CD3 recipient derived", "d": [], "t": []}], "preferred_name": "Cells.CD3 recipient derived", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0002506", "l": "liver CD103-positive dendritic cell", "d": ["A CD11b-positive dendritic cell that is CD11b-low, CD45-positive, MHC-II-high and CD103-positive that is located in the liver."], "t": []}], "preferred_name": "liver CD103-positive dendritic cell", "taxa": []}
{"type": "biolink:Cell", "ic": 71.57077045273823, "identifiers": [{"i": "UMLS:C1513949", "l": "Neoplastic Ductal Epithelial Cell", "d": [], "t": []}, {"i": "NCIT:C36877", "l": "Neoplastic Ductal Epithelial Cell", "d": [], "t": []}], "preferred_name": "Neoplastic Ductal Epithelial Cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5173415", "l": "Monoblasts | Blood | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Monoblasts | Blood | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4033101", "l": "superior cervical ganglion TH/DBH neuron", "d": ["A sympathetic neuron that has the soma located in the superior cervical ganglion and expresses the marker tyrosine hydroxylase (TH) and dopamine beta-hydroxylase (DBH)."], "t": []}], "preferred_name": "superior cervical ganglion TH/DBH neuron", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C3177154", "l": "Mononuclear+Mesothelial cells", "d": [], "t": []}], "preferred_name": "Mononuclear+Mesothelial cells", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5706543", "l": "Autologous Enhanced NY-ESO-1 TCR Engineered T-cells GSK4427296", "d": [], "t": []}], "preferred_name": "Autologous Enhanced NY-ESO-1 TCR Engineered T-cells GSK4427296", "taxa": []}
{"type": "biolink:Cell", "ic": 92.76600187037766, "identifiers": [{"i": "CL:0001072", "l": "CD34-negative, CD117-positive innate lymphoid cell, human", "d": ["An innate lymphoid cell in the human with the phenotype CD34-negative, CD117-positive, and a precusor to NK cells, ILC2 cells, and ILC3 cells."], "t": []}], "preferred_name": "CD34-negative, CD117-positive innate lymphoid cell, human", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5401598", "l": "Mesenchymoangioblast-derived mesenchymal stem cells", "d": [], "t": []}], "preferred_name": "Mesenchymoangioblast-derived mesenchymal stem cells", "taxa": []}
{"type": "biolink:Cell", "ic": 90.871710685482, "identifiers": [{"i": "CL:0002275", "l": "pancreatic PP cell", "d": ["A PP cell located in the islets of the pancreas."], "t": []}], "preferred_name": "pancreatic PP cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0282501", "l": "Spheroids, Cellular", "d": [], "t": []}, {"i": "MESH:D018874", "l": "Spheroids, Cellular", "d": [], "t": []}], "preferred_name": "Spheroids, Cellular", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C6008027", "l": "Oocyte of Graafian follicle", "d": [], "t": []}, {"i": "SNOMEDCT:1351746004", "l": "", "d": [], "t": []}], "preferred_name": "Oocyte of Graafian follicle", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5172508", "l": "Mesothelial cells | Synovial fluid | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Mesothelial cells | Synovial fluid | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:1000315", "l": "principal gastric gland goblet cell", "d": ["A goblet cell that is part of the epithelium of principal gastric gland."], "t": []}, {"i": "UMLS:C2332040", "l": "Goblet cell of epithelium of principal gastric gland", "d": [], "t": []}], "preferred_name": "principal gastric gland goblet cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5172547", "l": "Metamyelocytes | Body fluid | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Metamyelocytes | Body fluid | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5171664", "l": "Lymphocytes | Peritoneal fluid | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Lymphocytes | Peritoneal fluid | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0000777", "l": "mesangial phagocyte", "d": ["A tissue-resident macrophage of the renal glomerular mesangium involved in the disposal and degradation of filtration residues, presentation of antigen to T cells and in tissue remodeling."], "t": []}], "preferred_name": "mesangial phagocyte", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C2332989", "l": "Goblet cell of epithelium of small intestine", "d": [], "t": []}], "preferred_name": "Goblet cell of epithelium of small intestine", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "CL:1000022", "l": "mesonephric nephron tubule epithelial cell", "d": ["Any epithelial cell that is part of some mesonephric nephron tubule."], "t": []}], "preferred_name": "mesonephric nephron tubule epithelial cell", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "UMLS:C1881553", "l": "Malignant Epithelial Small Polygonal Cell", "d": [], "t": []}, {"i": "NCIT:C60996", "l": "Malignant Epithelial Small Polygonal Cell", "d": [], "t": []}], "preferred_name": "Malignant Epithelial Small Polygonal Cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C2924226", "l": "CD5+CD23+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:1373039009", "l": "", "d": [], "t": []}], "preferred_name": "CD5+CD23+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1636199", "l": "Adipose derived adult stem cell", "d": [], "t": []}, {"i": "SNOMEDCT:419288001", "l": "", "d": [], "t": []}], "preferred_name": "Adipose derived adult stem cell", "taxa": []}
{"type": "biolink:Cell", "ic": 92.76600187037766, "identifiers": [{"i": "UMLS:C1710695", "l": "Xanthomatous Fibrohistiocytic Cell", "d": [], "t": []}, {"i": "NCIT:C49081", "l": "Xanthomatous Fibrohistiocytic Cell", "d": [], "t": []}], "preferred_name": "Xanthomatous Fibrohistiocytic Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0020016", "l": "osteochondral skeletal stem cell", "d": ["A tissue-specific stem cell with long-term self-renewal capacity that is restricted to generating bone, cartilage, and stromal cell lineages. This cell is primarily located in the growth plate (resting zone), periosteum, and subchondral bone regions, and is marked by high clonogenicity and robust multipotent differentiation potential in both osteogenic and chondrogenic lineages. Distinctively, ocSSC lacks adipogenic capacity, distinguishing it from other mesenchymal stem cell populations."], "t": []}], "preferred_name": "osteochondral skeletal stem cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4324117", "l": "CD77+ B lymphocyte", "d": [], "t": []}], "preferred_name": "CD77+ B lymphocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 79.64650900338474, "identifiers": [{"i": "CL:0000092", "l": "osteoclast", "d": ["A specialized phagocytic cell associated with the absorption and removal of the mineralized matrix of bone tissue, which typically differentiates from monocytes. This cell has the following markers: tartrate-resistant acid phosphatase type 5-positive, PU.1-positive, c-fos-positive, nuclear factor NF-kappa-B p100 subunit-positive, tumor necrosis factor receptor superfamily member 11A-positive and macrophage colony-stimulating factor 1 receptor-positive."], "t": []}], "preferred_name": "osteoclast", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5419628", "l": "Autologous CD19/PD-1 Bispecific CAR-T Cells", "d": [], "t": []}, {"i": "NCIT:C172387", "l": "Autologous CD19/PD-1 Bispecific CAR-T Cells", "d": ["A preparation of autologous T-lymphocytes that are transduced with a lentiviral vector encoding a chimeric antigen receptor (CAR) specific for the tumor-associated antigen (TAA) cluster of differentiation 19 (CD19) and a programmed cell death protein 1 (PD1)/CD28 chimera, with potential immunomodulating and antineoplastic activities. Upon reintroduction into the patient, the autologous CD19/PD-1 bispecific CAR-T cells target and bind to CD19 and the PD-1 ligands, programmed cell death ligand 1 (PD-L1) and 2 (PD-L2), expressed on tumor cells. The binding to CD19 leads to a cytotoxic T-lymphocyte (CTL) response against CD19-expressing tumor cells and cell lysis of these cells. The binding of the PD1/CD28 chimera to PD-L1 prevents the normal PD1/PD-L1-mediated T-cell suppression and, instead, promotes signaling through the CD28 domain, which results in the stimulation of T-lymphocytes. This enhances T-lymphocyte proliferation and anti-tumor activity. CD19 antigen is a B-cell specific cell surface antigen overexpressed in B-cell lineage malignancies. PD-1 protein, found on activated T-cells, negatively regulates T-cell activity. It plays a key role in immune evasion and prevents tumor cell lysis. The construct of the PD1/CD28 chimera converts PD-L1 into a co-stimulation ligand of primary human CD8+ cytotoxic T-lymphocytes (CTLs). CD28 is a costimulatory molecule expressed by T-cells that enhances T-lymphocyte proliferation and activity."], "t": []}], "preferred_name": "Autologous CD19/PD-1 Bispecific CAR-T Cells", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C3829191", "l": "MART-1/gp100/Tyrosinase/MAGE-A3 Peptides-loaded Irradiated Allogeneic Plasmacytoid Dendritic Cells", "d": [], "t": []}, {"i": "NCIT:C107159", "l": "MART-1/gp100/Tyrosinase/MAGE-A3 Peptides-loaded Irradiated Allogeneic Plasmacytoid Dendritic Cells", "d": ["Irradiated allogeneic, HLA-A*0201 positive, plasmacytoid dendritic cells (pDCs) loaded with 4 melanoma peptides derived from the tumor associated antigens (TAAs) MelA/MART-1, gp100/pmel17, tyrosinase, and MAGE-A3, with potential immunostimulating and antineoplastic activities. Upon subcutaneous administration, the irradiated allogeneic pDCs may trigger functional multi-specific T cells from peripheral blood mononuclear cells and tumor-infiltrating lymphocytes, and activate the immune system to mount a cytotoxic T-lymphocyte response against HLA-A*0201 positive melanoma cancer cells expressing the TAAs MelA/MART-1, gp100/pmel17, tyrosinase, and MAGE-A3. These TAAs are upregulated in a variety of tumor cells. The pDCs are derived from a distinct subset of dendritic cells (DCs) with a plasma cell-like morphology and express a characteristic set of surface markers and may increase the anti-tumor immune responses."], "t": []}], "preferred_name": "MART-1/gp100/Tyrosinase/MAGE-A3 Peptides-loaded Irradiated Allogeneic Plasmacytoid Dendritic Cells", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0004240", "l": "WF1 amacrine cell", "d": ["An amacrine cell with a wide dendritic field, dendrites in S1, and post-synaptic terminals in S1."], "t": []}], "preferred_name": "WF1 amacrine cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C0229656", "l": "Promonocyte", "d": [], "t": []}, {"i": "NCIT:C13121", "l": "Promonocyte", "d": ["An immature cell of the mononuclear phagocytic system. It is the representation of one stage of monocyte development."], "t": []}, {"i": "SNOMEDCT:1075005", "l": "", "d": [], "t": []}], "preferred_name": "Promonocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C4329671", "l": "Circulating Tumor-Reactive T-Cell", "d": [], "t": []}, {"i": "NCIT:C131128", "l": "Circulating Tumor-Reactive T-Cell", "d": ["A population of T-lymphocytes that can mount an immune response against circulating tumor cells. These cells may spontaneously arise as a response to the presence of either endogenous tumor antigens or exogenous tumor antigens administered as a cancer vaccine."], "t": []}], "preferred_name": "Circulating Tumor-Reactive T-Cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5700405", "l": "Autologous Anti-BCMA CAR-T Cells JCARH 125", "d": [], "t": []}], "preferred_name": "Autologous Anti-BCMA CAR-T Cells JCARH 125", "taxa": []}
{"type": "biolink:Cell", "ic": 69.67647926784257, "identifiers": [{"i": "CL:0000955", "l": "pre-B-II cell", "d": ["A pre-B-II cell is a precursor B cell that expresses immunoglobulin mu heavy chain (IgHmu+), and lack expression of CD34, TdT, immunoglobulin kappa light chain and immunoglobulin lambda light chain."], "t": []}], "preferred_name": "pre-B-II cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C3830334", "l": "EFS-ADA Lentiviral Vector-transduced CD34-positive Autologous Lymphocytes", "d": [], "t": []}, {"i": "NCIT:C113438", "l": "EFS-ADA Lentiviral Vector-transduced CD34-positive Autologous Lymphocytes", "d": ["A preparation of autologous, CD34-positive stem/progenitor cells transduced with a lentrivral vector encoding the human adenosine deaminase (ADA) gene under the control of the human elongation factor alpha short promoter (EFS), with potential to restore ADA expression and function. Autologous hematopoietic CD34+ cells are isolated from the patient's own bone marrow, peripheral blood or cord blood, and transduced with the EFS-ADA lentiviral vector ex vivo. Upon re-infusion of the EFS-ADA vector-transduced lymphocytes back into the patient, these cells may both restore ADA activity and prevent severe combined immunodeficiency (SCID) due to ADA deficiency. ADA, an enzyme that catalyzes the deamination of adenosine to inosine, plays a key role in the development and functioning of the immune system."], "t": []}], "preferred_name": "EFS-ADA Lentiviral Vector-transduced CD34-positive Autologous Lymphocytes", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5186845", "l": "Neutrophils | Control | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Neutrophils | Control | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": 79.64650900338474, "identifiers": [{"i": "CL:0002653", "l": "squamous endothelial cell", "d": ["A squamous shaped endothelial cell."], "t": []}], "preferred_name": "squamous endothelial cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C2350052", "l": "Granulocyte Progenitor Cells", "d": [], "t": []}], "preferred_name": "Granulocyte Progenitor Cells", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "CL:1000384", "l": "type 2 vestibular sensory cell of epithelium of macula of saccule of membranous labyrinth", "d": ["A type II vestibular sensory cell that is part of the epithelium of macula of saccule of membranous labyrinth."], "t": []}, {"i": "UMLS:C2322731", "l": "Type 2 vestibular sensory cell of epithelium of macula of saccule of membranous labyrinth", "d": [], "t": []}], "preferred_name": "type 2 vestibular sensory cell of epithelium of macula of saccule of membranous labyrinth", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C6064630", "l": "Ki-67+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:1373076007", "l": "", "d": [], "t": []}], "preferred_name": "Ki-67+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0009066", "l": "stratified squamous epithelial cell of anal canal", "d": ["A stratified squamous epithelial cell that is part of the anal canal."], "t": []}], "preferred_name": "stratified squamous epithelial cell of anal canal", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:1001213", "l": "arcuate artery endothelial cell", "d": ["Any endothelial cell that is part of some kidney arcuate artery."], "t": []}], "preferred_name": "arcuate artery endothelial cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0333799", "l": "Basket cell erythrocyte", "d": [], "t": []}, {"i": "SNOMEDCT:54244009", "l": "", "d": [], "t": []}], "preferred_name": "Basket cell erythrocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0002161", "l": "superficial external epithelial cell of tympanic membrane", "d": ["A cell type found on the superficial layer of the external side of the tympanic membrane. This cell-type lacks a nucleus."], "t": []}], "preferred_name": "superficial external epithelial cell of tympanic membrane", "taxa": []}
{"type": "biolink:Cell", "ic": 76.78008365410358, "identifiers": [{"i": "CL:0000453", "l": "Langerhans cell", "d": ["Langerhans cell is a conventional dendritic cell that has plasma membrane part CD207. A Langerhans cell is a stellate dendritic cell of myeloid origin, that appears clear on light microscopy and has a dark-staining, indented nucleus and characteristic inclusions (Birbeck granules) in the cytoplasm; Langerhans cells are found principally in the stratum spinosum of the epidermis, but they also occur in other stratified epithelia and have been identified in the lung, lymph nodes, spleen, and thymus."], "t": []}, {"i": "UMLS:C0023005", "l": "Langerhans cell", "d": [], "t": []}, {"i": "NCIT:C12584", "l": "Langerhans Cell", "d": ["Dendritic clear cells in the epidermis, containing distinctive granules that appear rod- or racket-shaped in section, but lacking tonofilaments, melanosomes, and desmosomes; they carry surface receptors for immunoglobulin (Fc) and complement (C3), and are believed to be antigen fixing and processing cells of monocytic origin; active participants in cutaneous delayed hypersensitivity."], "t": []}, {"i": "MESH:D007801", "l": "Langerhans Cells", "d": [], "t": []}, {"i": "SNOMEDCT:76322003", "l": "", "d": [], "t": []}], "preferred_name": "Langerhans cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5418106", "l": "Autologous Anti-CD19CAR-4-1BB/CD3zeta-HER2tG-expressing CD4+/CD8+ T-lymphocytes SCRI-huCAR19v2", "d": [], "t": []}, {"i": "NCIT:C174563", "l": "Autologous Anti-CD19CAR-4-1BB/CD3zeta-HER2tG-expressing CD4+/CD8+ T-lymphocytes SCRI-huCAR19v2", "d": ["A preparation of autologous CD4- and CD8-positive T-lymphocytes that have been transduced with a lentiviral vector (LV) expressing a chimeric antigen receptor (CAR) specific for the human tumor-associated antigen (TAA) CD19 that is fused to the intracellular cytoplasmic domain of 4-1BB (CD137) and the zeta chain of the TCR/CD3 complex (CD3zeta), and linked to a truncated form of the human epidermal growth factor receptor 2 (HER2tG), with potential immunostimulating and antineoplastic activities. Upon administration, the autologous anti-CD19CAR-4-1BB/CD3zeta-HER2tG-expressing CD4+/CD8+ T-lymphocytes SCRI-huCAR19v2 specifically target and bind to CD19-expressing neoplastic B-cells. This results in a cytotoxic T-lymphocyte (CTL) response against CD19-expressing tumor cells and causes tumor cell lysis. CD19 is a B-cell-specific cell surface antigen that is overexpressed in B-cell lineage tumors. Incorporation of the costimulatory signaling domain increases human T-cell function, expansion, and survival. Devoid of both ligand binding domains and tyrosine kinase activity, the co-expressed HER2tG both facilitates in vivo detection of the administered, transduced T-cells and can promote elimination of those cells through a trastuzumab-induced antibody dependent cellular cytotoxicity (ADCC) response."], "t": []}], "preferred_name": "Autologous Anti-CD19CAR-4-1BB/CD3zeta-HER2tG-expressing CD4+/CD8+ T-lymphocytes SCRI-huCAR19v2", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0004001", "l": "local interneuron", "d": ["An interneuron whose axon stays entirely within the gray matter region where the cell body resides."], "t": []}], "preferred_name": "local interneuron", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5382939", "l": "Interferon-gamma producing HLA-A1 Cytomegalovirus specific CD8 cells | Blood | Cell markers", "d": [], "t": []}], "preferred_name": "Interferon-gamma producing HLA-A1 Cytomegalovirus specific CD8 cells | Blood | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1440417", "l": "Cells.t(9;22)(q34.1;q11)(ABL1,BCR)", "d": [], "t": []}], "preferred_name": "Cells.t(9;22)(q34.1;q11)(ABL1,BCR)", "taxa": []}
{"type": "biolink:Cell", "ic": 79.9528279018387, "identifiers": [{"i": "UMLS:C1706984", "l": "Bone Marrow Stem Cell Committed to the Megakaryocytic Lineage", "d": [], "t": []}, {"i": "NCIT:C43221", "l": "Bone Marrow Stem Cell Committed to the Megakaryocytic Lineage", "d": ["A primitive undifferentiated cell which can undergo division and can give rise to one of the early megakaryocytes."], "t": []}], "preferred_name": "Bone Marrow Stem Cell Committed to the Megakaryocytic Lineage", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5853683", "l": "allogeneic CRISPR/Cas9-mediated genetically modified CAR T cells targeting B-cell maturation antigen", "d": [], "t": []}], "preferred_name": "allogeneic CRISPR/Cas9-mediated genetically modified CAR T cells targeting B-cell maturation antigen", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1515137", "l": "T-Immunoblast", "d": [], "t": []}, {"i": "NCIT:C34034", "l": "T-Immunoblast", "d": ["A T-lymphocyte that has been transformed (activated) in response to antigenic stimulation. It will give rise to a population of T cells with specificity against the stimulating antigen."], "t": []}], "preferred_name": "T-Immunoblast", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5983804", "l": "Anti-GPRC5D/Anti-CD19 CAR T Cells", "d": [], "t": []}, {"i": "NCIT:C212050", "l": "Anti-GPRC5D/Anti-CD19 CAR T Cells", "d": ["A preparation of T-lymphocytes engineered to express chimeric antigen receptor(s) (CARs) targeting the human tumor-associated antigens (TAAs) G-protein coupled receptor family C group 5 member D (GPRC5D) and CD19, with potential immunostimulating and antineoplastic activities. Upon administration, anti-GPRC5D/anti-CD19 CAR T cells specifically and simultaneously target and bind to tumor cells expressing GPRC5D and/or CD19. This induces selective toxicity in tumor cells that express GPRC5D and/or CD19. GPRC5D is overexpressed in certain malignancies, such as multiple myeloma, while minimally expressed in normal, healthy cells. It plays a key role in tumor cell proliferation. CD19 is a B-cell-specific cell surface antigen overexpressed in B-cell lineage malignancies."], "t": []}], "preferred_name": "Anti-GPRC5D/Anti-CD19 CAR T Cells", "taxa": []}
{"type": "biolink:Cell", "ic": 60.799863983285036, "identifiers": [{"i": "CL:0001201", "l": "B cell, CD19-positive", "d": ["A B cell that is CD19-positive."], "t": []}], "preferred_name": "B cell, CD19-positive", "taxa": []}
{"type": "biolink:Cell", "ic": 70.66959805369461, "identifiers": [{"i": "CL:4023120", "l": "cochlea auditory hair cell", "d": ["An auditory hair cell found in the cochlea."], "t": []}], "preferred_name": "cochlea auditory hair cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5179532", "l": "Reticulocytes.medium fluorescence/100 erythrocytes | Blood | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Reticulocytes.medium fluorescence/100 erythrocytes | Blood | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4072012", "l": "A15 dopaminergic neuron", "d": ["A type of dopaminergic neuron located in the preoptic periventricular nucleus of the hypothalamus and implicated in neuroendocrine modulation."], "t": []}], "preferred_name": "A15 dopaminergic neuron", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1181301", "l": "Inactive chief cell of parathyroid gland", "d": [], "t": []}], "preferred_name": "Inactive chief cell of parathyroid gland", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5181345", "l": "Spermatozoa Agglutinated | Semen | Fertility testing", "d": [], "t": []}], "preferred_name": "Spermatozoa Agglutinated | Semen | Fertility testing", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5163682", "l": "Erythrocyte clumps | Urine | Urinalysis", "d": [], "t": []}], "preferred_name": "Erythrocyte clumps | Urine | Urinalysis", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5417771", "l": "Viralym-M", "d": [], "t": []}], "preferred_name": "Viralym-M", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1440255", "l": "CD138+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:1372848009", "l": "", "d": [], "t": []}], "preferred_name": "CD138+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0000870", "l": "Peyer's patch macrophage", "d": ["A gut-associated lymphoid tissue macrophage found in the Peyer's patches."], "t": []}], "preferred_name": "Peyer's patch macrophage", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5417981", "l": "Autologous Anti-BCMA CD8+ CAR T-cells Descartes-11", "d": [], "t": []}, {"i": "NCIT:C173434", "l": "Autologous Anti-BCMA CD8+ CAR T-cells Descartes-11", "d": ["A preparation of autologous CD8-positive T-lymphocytes that have been genetically modified to express a chimeric antigen receptor (CAR) specific for the tumor-associated antigen (TAA) human B-cell maturation antigen (BCMA; tumor necrosis factor receptor superfamily member 17; TNFRSF17), with potential immunostimulating and antineoplastic activities. Upon administration, autologous anti-BCMA CD8+ CAR T-cells Descartes-11 specifically recognize and induce selective toxicity in BCMA-expressing tumor cells. BCMA, a tumor-specific antigen and a receptor for both a proliferation-inducing ligand (APRIL) and B-cell activating factor (BAFF), is a member of the tumor necrosis factor receptor superfamily (TNFRSF) and plays a key role in plasma cell survival. BCMA is found on the surfaces of plasma cells and is overexpressed on malignant plasma cells."], "t": []}], "preferred_name": "Autologous Anti-BCMA CD8+ CAR T-cells Descartes-11", "taxa": []}
{"type": "biolink:Cell", "ic": 52.83798421525256, "identifiers": [{"i": "UMLS:C5961019", "l": "Cell Therapy Agent", "d": [], "t": []}, {"i": "NCIT:C208191", "l": "Cell Therapy Agent", "d": ["A preparation of one or more cell type(s) that is meant to be administered to a patient for a specific therapeutic effect."], "t": []}], "preferred_name": "Cell Therapy Agent", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5203880", "l": "Autologous Anti-GD2CAR-CD28-CD3zeta-IL-15-expressing Natural Killer T-cells", "d": [], "t": []}, {"i": "NCIT:C158682", "l": "Autologous Anti-GD2CAR-CD28-CD3zeta-IL-15-expressing Natural Killer T-cells", "d": ["A preparation of autologous natural killer T-lymphocytes (NKTs) that have been transduced with a retroviral vector to express both an extracellular domain consisting of interleukin 15 (IL-15) and a chimeric antigen receptor (CAR) specific for the human tumor associated antigen (TAA) GD2, linked to the CD28 and CD3zeta (TCRzeta; CD247) costimulatory signaling domains, with potential antineoplastic activity. Upon intravenous administration, autologous anti-GD2CAR-CD28-CD3zeta-IL-15-expressing NKTs target, bind to, and induce selective toxicity in GD2-expressing tumor cells. IL-15 is a pro-survival cytokine that promotes T-cell persistence and potentiates the immune response against tumor cells. Incorporation of the costimulatory signaling domains increases T-cell function, expansion, and survival. The CD28 costimulatory molecule signaling domain enhances activation and signaling after recognition of GD2. Additionally, inclusion of the CD28 signaling domain may increase proliferation of T-cells and antitumor activity compared to the inclusion of the CD3zeta chain alone. GD2, a disialoganglioside and tumor-associated antigen (TAA), is overexpressed in a variety of tumor cell types."], "t": []}], "preferred_name": "Autologous Anti-GD2CAR-CD28-CD3zeta-IL-15-expressing Natural Killer T-cells", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C0225323", "l": "Lipoblast (cell)", "d": [], "t": []}, {"i": "NCIT:C32990", "l": "Lipoblast", "d": ["A connective tissue cell that develops into a fat cell."], "t": []}, {"i": "SNOMEDCT:81186000", "l": "", "d": [], "t": []}, {"i": "SNOMEDCT:82851002", "l": "", "d": [], "t": []}], "preferred_name": "Lipoblast (cell)", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5787281", "l": "Autologous IL-7Ra-expressing Tris-CAR T-cells", "d": [], "t": []}, {"i": "NCIT:C192816", "l": "Autologous IL-7Ra-expressing Tris-CAR T-cells", "d": ["A preparation of autologous T-lymphocytes that have been genetically modified and lentivirally transduced to express a dual-target chimeric antigen receptor (CAR) and a truncated form of the cytokine receptor interleukin-7 (IL-7) receptor alpha (IL-7Ra), with potential immunostimulating and antineoplastic activities. Upon administration, autologous IL-7Ra-expressing Tris-CAR T-cells target and bind to tumor cells expressing the targets, thereby inducing selective toxicity in these tumor cells. In addition, as IL-7/IL-7Ra-mediated signaling promotes the proliferation and survival of T-cells, these tumor re-directed T-cells may show enhanced expansion, survival and cytotoxicity."], "t": []}], "preferred_name": "Autologous IL-7Ra-expressing Tris-CAR T-cells", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5909379", "l": "Autologous Tumor-draining Lymph Node-derived Lymphocytes", "d": [], "t": []}, {"i": "NCIT:C203658", "l": "Autologous Tumor-draining Lymph Node-derived Lymphocytes", "d": ["A preparation of autologous lymphocytes that are isolated from each patient's tumor-draining lymph nodes and expanded ex vivo, with potential immunomodulating and antineoplastic activities. Upon administration back into the patient, the autologous tumor-draining LNLs specifically recognize and kill the patient's tumor cells."], "t": []}], "preferred_name": "Autologous Tumor-draining Lymph Node-derived Lymphocytes", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "CL:0002376", "l": "non-myelinating Schwann cell", "d": ["A glial cell that ensheaths multiple small diameter axons in the peripheral nervous system. The non-myelinating Schwann cell is embedded among neurons (axons) with minimal extracellular spaces separating them from nerve cell membranes and has a basal lamina. Cells can survive without an axon present. These cells can de-differentiate into immature Schwann cells."], "t": []}], "preferred_name": "non-myelinating Schwann cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1267971", "l": "Lymphocyte positive for CD79B antigen", "d": [], "t": []}, {"i": "SNOMEDCT:117411006", "l": "", "d": [], "t": []}], "preferred_name": "Lymphocyte positive for CD79B antigen", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5556648", "l": "Autologous Anti-CD19 CAR Vector-transduced T Cells pCAR-19B", "d": [], "t": []}, {"i": "NCIT:C180824", "l": "Autologous Anti-CD19 CAR Vector-transduced T Cells pCAR-19B", "d": ["A preparation of autologous T-lymphocytes that have been genetically modified and transduced with a vector encoding a chimeric antigen receptor (CAR) specific for the tumor-associated antigen (TAA) cluster of differentiation (CD) 19, with potential immunostimulating and antineoplastic activities. Upon administration, autologous anti-CD19 CAR vector-transduced T-cells pCAR-19B specifically recognize and kill CD19-expressing tumor cells. CD19 antigen is a B-cell specific cell surface antigen expressed in all B-cell lineage malignancies."], "t": []}], "preferred_name": "Autologous Anti-CD19 CAR Vector-transduced T Cells pCAR-19B", "taxa": []}
{"type": "biolink:Cell", "ic": 88.20185721311867, "identifiers": [{"i": "CL:0000772", "l": "immature eosinophil", "d": ["Any of the immature forms of an eosinophil, in which eosinophilic specific granules are present but other phenotypic features of the mature form may be lacking."], "t": []}], "preferred_name": "immature eosinophil", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C2348928", "l": "HLA-Matched Donor Mononuclear Cell-Enriched Leukocytes Apocell", "d": [], "t": []}, {"i": "NCIT:C71162", "l": "HLA-Matched Donor Mononuclear Cell-Enriched Leukocytes Apocell", "d": ["A preparation of allogeneic HLA-matched leukocytes treated with a derivative of placental protein 14 (PP14) with potential immunomodulating activity. PP14 derivative-treated HLA-matched donor mononuclear cell-enriched leukocytes contain at least fifty-five percent early-apoptotic T cells; after infusion and when processed by recipient dendritic cells, early-apoptotic T cells may help induce a decrease in the donor effector T-cell responses against the recipient of an allogeneic hematopoietic stem cell (HSC) transplant, thereby minimizing allogeneic HSC transplant-related graft-versus-host disease (GVHD). PP14, a 162 amino acid glycosylated protein secreted by the late secretory phase endometrium, binds to T cells in a carbohydrate fashion and has been shown to induce T-cell apoptosis; maternal immune tolerance to the fetus and pregnancy-related remissions of autoimmune disease may involve PP14-induced T cell apoptosis."], "t": []}], "preferred_name": "HLA-Matched Donor Mononuclear Cell-Enriched Leukocytes Apocell", "taxa": []}
{"type": "biolink:Cell", "ic": 90.871710685482, "identifiers": [{"i": "CL:2000020", "l": "inner cell mass cell", "d": ["Any native cell that is part of a inner cell mass."], "t": []}], "preferred_name": "inner cell mass cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1514043", "l": "Neoplastic Neural Crest Cell", "d": [], "t": []}, {"i": "NCIT:C37148", "l": "Neoplastic Neural Crest Cell", "d": [], "t": []}], "preferred_name": "Neoplastic Neural Crest Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 67.18460065295824, "identifiers": [{"i": "UMLS:C1513974", "l": "Neoplastic Glandular Cell with Clear Cytoplasm", "d": [], "t": []}, {"i": "NCIT:C36765", "l": "Neoplastic Glandular Cell with Clear Cytoplasm", "d": [], "t": []}], "preferred_name": "Neoplastic Glandular Cell with Clear Cytoplasm", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1179787", "l": "Vacuolar absorptive cell", "d": [], "t": []}], "preferred_name": "Vacuolar absorptive cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5164690", "l": "FLAER cells | Blood | Cell markers", "d": [], "t": []}], "preferred_name": "FLAER cells | Blood | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": 90.871710685482, "identifiers": [{"i": "UMLS:C1513872", "l": "Naive Pregerminal Center B-Lymphocyte", "d": [], "t": []}, {"i": "NCIT:C38337", "l": "Naive Pregerminal Center B-Lymphocyte", "d": ["A mature B lymphocyte that expresses IgM and IgD. It is found in peripheral blood, lymph nodes and secondary lymphoid organs, but has not moved into the germinal center of lymphoid organs. Once this cell encounters an antigen in the presence of helper T cells and becomes activated, it moves to the next stage of B-lymphocyte development."], "t": []}], "preferred_name": "Naive Pregerminal Center B-Lymphocyte", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1267870", "l": "Lymphocyte positive for CD12 antigen", "d": [], "t": []}, {"i": "SNOMEDCT:117549007", "l": "", "d": [], "t": []}], "preferred_name": "Lymphocyte positive for CD12 antigen", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5908158", "l": "Autologous Anti-L1CAM-CAR-EGFRt-expressing T-cells", "d": [], "t": []}, {"i": "NCIT:C201687", "l": "Autologous Anti-L1CAM-CAR-EGFRt-expressing T-cells", "d": ["A preparation of autologous human T-lymphocytes expressing a chimeric antigen receptor (CAR) specific for the L1 cell adhesion molecule (L1CAM; L1-CAM; CD171) antigen and a truncated form of the human epidermal growth factor receptor (EGFRt), with potential immunostimulating and antineoplastic activities. Upon re-infusion into the patient, the autologous anti-L1CAM-CAR-EGFRt-expressing T-cells are directed to and induce selective toxicity in L1CAM-expressing tumor cells. L1CAM, a neuronal cell adhesion molecule and member of the L1 protein family, plays a key role in the development of the nervous system; it is overexpressed in various tumor cell types and is associated with increased chemoresistance, tumor progression, migration and metastasis. Devoid of both ligand-binding domains and tyrosine kinase activity, EGFRt facilitates both the detection of the administered T-cells in vivo and the elimination of the modified T-cells following a cetuximab-induced antibody-dependent cellular cytotoxicity (ADCC) response."], "t": []}], "preferred_name": "Autologous Anti-L1CAM-CAR-EGFRt-expressing T-cells", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5571672", "l": "Leukocytes|NCnc|Pt|BAL", "d": [], "t": []}], "preferred_name": "Leukocytes|NCnc|Pt|BAL", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0004244", "l": "WF4 amacrine cell", "d": ["An amacrine cell with a wide dendritic field, dendrites in S4, and post-synaptic terminals in S4."], "t": []}], "preferred_name": "WF4 amacrine cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1518754", "l": "Mouse Ovarian Sertoli Cell", "d": [], "t": []}, {"i": "NCIT:C22665", "l": "Mouse Ovarian Sertoli Cell", "d": [], "t": []}], "preferred_name": "Mouse Ovarian Sertoli Cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5980662", "l": "Cells.CD3+CD4+|Bld (LG52050-8)", "d": [], "t": []}], "preferred_name": "Cells.CD3+CD4+|Bld (LG52050-8)", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5157547", "l": "CD4+CD45RA+CD45RB+CD45RC+ cells | Cerebral spinal fluid | Cell markers", "d": [], "t": []}], "preferred_name": "CD4+CD45RA+CD45RB+CD45RC+ cells | Cerebral spinal fluid | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5833283", "l": "CD3 cells | Donor | Blood | Cell markers", "d": [], "t": []}], "preferred_name": "CD3 cells | Donor | Blood | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0229606", "l": "Reticulum cell", "d": [], "t": []}, {"i": "SNOMEDCT:37510001", "l": "", "d": [], "t": []}], "preferred_name": "Reticulum cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C3176908", "l": "Cells.cytoplasmic Ig", "d": [], "t": []}], "preferred_name": "Cells.cytoplasmic Ig", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C4733647", "l": "Autologous Anti-CD19CAR-HER2t/CD22CAR-EGFRt-expressing T-cells", "d": [], "t": []}, {"i": "NCIT:C155897", "l": "Autologous Anti-CD19CAR-HER2t/CD22CAR-EGFRt-expressing T-cells", "d": ["A preparation of autologous human T-lymphocytes engineered to express dual chimeric antigen receptors (CARs) consisting of both anti-CD19 and anti-CD22 binding domains, fused to an as of yet undisclosed co-stimulatory domain, and linked to truncated forms of the human epidermal growth factor receptor 2 (HER2t) and the human epidermal growth factor receptor (EGFRt), respectively with potential immunostimulating and antineoplastic activities. Upon administration, the autologous anti-CD19CAR-HER2t/CD22CAR-EGFRt-expressing T-cells bind to CD19 and CD22 on the surface of, and induce selective toxicity against tumor cells expressing CD19 and CD22. Devoid of both ligand binding domains and tyrosine kinase activity, the expressed EGFRt and HER2t facilitate both in vivo detection of the administered, transduced T-cells and can promote elimination of those cells through an antibody-dependent cellular cytotoxicity (ADCC) response. CD19 and CD22, both transmembrane phosphoglycoproteins expressed on the surface of cells in the B lineage, are often overexpressed on malignant B-cells."], "t": []}], "preferred_name": "Autologous Anti-CD19CAR-HER2t/CD22CAR-EGFRt-expressing T-cells", "taxa": []}
{"type": "biolink:Cell", "ic": 73.613037951824, "identifiers": [{"i": "UMLS:C2346938", "l": "Malignant Trophoblastic Cell", "d": [], "t": []}, {"i": "NCIT:C68658", "l": "Malignant Trophoblastic Cell", "d": [], "t": []}], "preferred_name": "Malignant Trophoblastic Cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0333720", "l": "Glycogenic cell", "d": [], "t": []}, {"i": "SNOMEDCT:58726005", "l": "", "d": [], "t": []}], "preferred_name": "Glycogenic cell", "taxa": []}
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{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1440239", "l": "CD107a+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:725723007", "l": "", "d": [], "t": []}], "preferred_name": "CD107a+ cell", "taxa": []}
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{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5853907", "l": "Ex vivo expanded allogeneic cord blood-derived NK cells that have been genetically modified to express a HER2-directed CAR and secrete IL-15", "d": [], "t": []}], "preferred_name": "Ex vivo expanded allogeneic cord blood-derived NK cells that have been genetically modified to express a HER2-directed CAR and secrete IL-15", "taxa": []}
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{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0002200", "l": "oxyphil cell of thyroid", "d": ["An oncocyte located in the thyroid."], "t": []}], "preferred_name": "oxyphil cell of thyroid", "taxa": []}
{"type": "biolink:Cell", "ic": 84.83823963392128, "identifiers": [{"i": "CL:1000617", "l": "kidney inner medulla cell", "d": ["Any kidney medulla cell that is part of some inner medulla of kidney."], "t": []}], "preferred_name": "kidney inner medulla cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5958737", "l": "Autologous Anti-B7-H3 CAR-iC9-expressing T-lymphocytes", "d": [], "t": []}, {"i": "NCIT:C204924", "l": "Autologous Anti-B7-H3 CAR-iC9-expressing T-lymphocytes", "d": ["A preparation of autologous T-lymphocytes that have been genetically modified to express a chimeric antigen receptor (CAR) specific for the immunoregulatory protein B7-homologue 3 (B7-H3, CD276) and the suicide gene inducible caspase 9 (iCasp9 or iC9), with potential immunostimulating and antineoplastic activities. Upon administration, autologous anti-B7-H3 CAR-iC9-expressing T-lymphocytes specifically target and bind to B7-H3-expressing tumor cells, resulting in tumor cell lysis. B7-H3, a type I transmembrane protein and a member of the B7 co-stimulatory protein superfamily, is overexpressed on certain tumor cell types and on various immune cells. It is a negative regulator of T-cell activation and its overexpression plays a key role in tumor cell invasion and metastasis. The iCasp9 safety switch consists of a full-length caspase 9, including its caspase recruitment domain, linked to a human FK506 drug-binding domain with an F36V mutation (FKBP12-F36V). If the administered CAR T-cells lead to unacceptable side effects, the chemical homodimerizer AP1903 can be administered. AP1903 binds to the FKBP12-F36V drug-binding domain, activates caspase 9 and results in apoptosis of the administered CAR T-cells."], "t": []}], "preferred_name": "Autologous Anti-B7-H3 CAR-iC9-expressing T-lymphocytes", "taxa": []}
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{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0524459", "l": "Lower motor neuron", "d": [], "t": []}, {"i": "SNOMEDCT:91770004", "l": "", "d": [], "t": []}], "preferred_name": "Lower motor neuron", "taxa": []}
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{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4510888", "l": "Blast cell positive for CD123 antigen", "d": [], "t": []}, {"i": "SNOMEDCT:724307004", "l": "", "d": [], "t": []}], "preferred_name": "Blast cell positive for CD123 antigen", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5854599", "l": "CAR NK Cells SZ003", "d": [], "t": []}, {"i": "NCIT:C200812", "l": "CAR NK Cells SZ003", "d": ["A preparation of natural killer cells (NKs) expressing a chimeric antigen receptor (CAR) specific for an as of yet undisclosed tumor-associated antigen (TAA), with potential immunomodulating and antineoplastic activities. Upon administration, the CAR NK cells SZ003 recognize and induce selective cytotoxicity in tumor cells expressing the TAA."], "t": []}], "preferred_name": "CAR NK Cells SZ003", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C3496150", "l": "A4 cell group", "d": [], "t": []}], "preferred_name": "A4 cell group", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "CL:4030054", "l": "D1-NUDAP medium spiny neuron", "d": ["A DRD1-expressing medium spiny neuron that is part of dense, RXFP1-positive cell islands throughout the nucleus accumbens, putamen, and near the adjacent septal nuclei."], "t": []}], "preferred_name": "D1-NUDAP medium spiny neuron", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0002143", "l": "dark chief cell of parathyroid gland", "d": ["A chief cell that is smaller than light chief cells and has a smaller and darker nucleus and a finely granular cytoplasm with many granules."], "t": []}, {"i": "UMLS:C1181298", "l": "Dark chief cell of parathyroid gland", "d": [], "t": []}], "preferred_name": "dark chief cell of parathyroid gland", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1522257", "l": "Mouse Mesodermal Cell", "d": [], "t": []}, {"i": "NCIT:C22686", "l": "Mouse Mesodermal Cell", "d": [], "t": []}], "preferred_name": "Mouse Mesodermal Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C3831522", "l": "Anti-CD19-CAR FMC63-28Z Retroviral Vector-transduced Allogeneic T-lymphocytes", "d": [], "t": []}, {"i": "NCIT:C111041", "l": "Anti-CD19-CAR FMC63-28Z Retroviral Vector-transduced Allogeneic T-lymphocytes", "d": ["Allogeneic T-lymphocytes derived from peripheral blood mononuclear cells (PBMC) transduced with a retroviral vector expressing a chimeric antigen receptor (CAR) consisting of both the light and heavy chain variable regions of anti-CD19 monoclonal antibody FMC63, coupled to the molecule CD28 and the signaling domain of the zeta chain of the T-cell receptor (TCR) (FMC63-28Z), with potential immunomodulating and antineoplastic activities. Upon transfusion, the anti-CD19-CAR FMC63-28Z retroviral vector-transduced allogeneic T lymphocytes specifically recognize and kill CD19-expressing tumor cells. CD19 antigen is a B-cell specific cell surface antigen, which is expressed in all B-cell lineage malignancies and normal B-cells."], "t": []}], "preferred_name": "Anti-CD19-CAR FMC63-28Z Retroviral Vector-transduced Allogeneic T-lymphocytes", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1440324", "l": "CD49d+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:1372901006", "l": "", "d": [], "t": []}], "preferred_name": "CD49d+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0882904", "l": "CD57+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:1372909008", "l": "", "d": [], "t": []}], "preferred_name": "CD57+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0229213", "l": "Rod cell of inner nuclear layer", "d": [], "t": []}, {"i": "SNOMEDCT:34407003", "l": "", "d": [], "t": []}], "preferred_name": "Rod cell of inner nuclear layer", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "UMLS:C1709585", "l": "Pluripotent Primordial Germ Cell", "d": [], "t": []}, {"i": "NCIT:C45735", "l": "Pluripotent Primordial Germ Cell", "d": [], "t": []}], "preferred_name": "Pluripotent Primordial Germ Cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C2338888", "l": "Paneth cell of epithelium of small intestine", "d": [], "t": []}], "preferred_name": "Paneth cell of epithelium of small intestine", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1710528", "l": "Umbilical Cord Blood Stem Cell", "d": [], "t": []}, {"i": "NCIT:C43424", "l": "Umbilical Cord Blood Stem Cell", "d": ["A stem cell obtained from the umbilical cord."], "t": []}], "preferred_name": "Umbilical Cord Blood Stem Cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0333769", "l": "Vacuolated fibers", "d": [], "t": []}, {"i": "SNOMEDCT:71272000", "l": "", "d": [], "t": []}], "preferred_name": "Vacuolated fibers", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C2346937", "l": "Malignant Ovoid Osteoblast", "d": [], "t": []}, {"i": "NCIT:C67522", "l": "Malignant Ovoid Osteoblast", "d": [], "t": []}], "preferred_name": "Malignant Ovoid Osteoblast", "taxa": []}
{"type": "biolink:Cell", "ic": 89.40238429118027, "identifiers": [{"i": "CL:0002172", "l": "interdental cell of cochlea", "d": ["A long, spindle-shaped supporting cells arranged in parallel rows that secretes components of the tectorial membrane and potassium ions into the endolymph."], "t": []}, {"i": "UMLS:C2331294", "l": "Interdental cell of cochlea", "d": [], "t": []}], "preferred_name": "interdental cell of cochlea", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5174621", "l": "Neutrophils | Peritoneal fluid | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Neutrophils | Peritoneal fluid | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C3640209", "l": "Mesothelin-specific Chimeric Antigen Receptor-engineered Peripheral Blood Lymphocytes", "d": [], "t": []}, {"i": "NCIT:C101773", "l": "Mesothelin-specific Chimeric Antigen Receptor-engineered Peripheral Blood Lymphocytes", "d": ["A preparation of peripheral blood lymphocytes (PBLs) transduced with a retroviral vector encoding a T cell chimeric antigen receptor (CAR) specific for mesothelin with potential immunostimulatory and antineoplastic activities. After transduction, expansion in culture, and reintroduction into the patient, the mesothelin-specific chimeric antigen receptor-engineered PBLs bind to tumor cells expressing mesothelin. This may stimulate the secretion of cytokines and result in cell lysis of mesothelin-expressing cancer cells. Mesothelin, a cell surface glycoprotein involved in cell adhesion, is overexpressed in many epithelial-derived cancers."], "t": []}], "preferred_name": "Mesothelin-specific Chimeric Antigen Receptor-engineered Peripheral Blood Lymphocytes", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C4725915", "l": "Autologous GPC3/NY-ESO-1/AFP specific CD8-positive T-lymphocytes", "d": [], "t": []}, {"i": "NCIT:C150676", "l": "Autologous GPC3/NY-ESO-1/AFP specific CD8-positive T-lymphocytes", "d": ["A preparation of autologous CD8-positive T-lymphocytes that are exposed, ex vivo, to multiple specific hepatocellular carcinoma (HCC) antigens, including glypican (GPC)-3, New York esophageal squamous cell carcinoma-1 (NY-ESO-1) and alpha-fetoprotein (AFP), with potential immunostimulating and antineoplastic activities. Upon infusion of the GPC3/NY-ESO-1/AFP-specific CD8-positive T lymphocytes, the T-cells specifically target and lyse cells expressing the targeted HCC neoantigens."], "t": []}], "preferred_name": "Autologous GPC3/NY-ESO-1/AFP specific CD8-positive T-lymphocytes", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5171750", "l": "Lymphocytes+Monocytes | Blood | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Lymphocytes+Monocytes | Blood | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0002636", "l": "nonkeratinized epithelial cell of inferior part of anal canal", "d": ["A nonkeratinized cell epithleial cell of the inferior part of the anal canal."], "t": []}, {"i": "UMLS:C2324226", "l": "Nonkeratinized cell of epithelium of inferior part of anal canal", "d": [], "t": []}], "preferred_name": "nonkeratinized epithelial cell of inferior part of anal canal", "taxa": []}
{"type": "biolink:Cell", "ic": 73.613037951824, "identifiers": [{"i": "CL:2000049", "l": "primary motor cortex pyramidal cell", "d": ["Any pyramidal cell that is part of a primary motor cortex."], "t": []}], "preferred_name": "primary motor cortex pyramidal cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5426719", "l": "Viable CD3 cells", "d": [], "t": []}], "preferred_name": "Viable CD3 cells", "taxa": []}
{"type": "biolink:Cell", "ic": 92.76600187037766, "identifiers": [{"i": "CL:4042023", "l": "striatal pthlh-expressing interneuron", "d": ["A GABAergic interneuron expressing PTHLH and PVALB that has its soma in a striatum. This GABAergic interneuron type presents a spatial expression gradient of PVALB in the mouse striatum."], "t": []}], "preferred_name": "striatal pthlh-expressing interneuron", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4517923", "l": "Population of all round cells in portion of fluid", "d": [], "t": []}, {"i": "SNOMEDCT:732289008", "l": "", "d": [], "t": []}], "preferred_name": "Population of all round cells in portion of fluid", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5157533", "l": "CD4 cells | XXX | Cell markers", "d": [], "t": []}], "preferred_name": "CD4 cells | XXX | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0002249", "l": "primitive cardiac myocyte", "d": ["A stem cell that can differentiate into a cardiac myocyte."], "t": []}, {"i": "UMLS:C1184809", "l": "Primitive cardiac myocyte", "d": [], "t": []}], "preferred_name": "primitive cardiac myocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5236075", "l": "NSCLC-specific Marrow Infiltrating Lymphocytes", "d": [], "t": []}, {"i": "NCIT:C164230", "l": "NSCLC-specific Marrow Infiltrating Lymphocytes", "d": ["A preparation of autologous, ex-vivo activated and expanded, bone marrow-derived infiltrating lymphocytes (MILs) from a non-small cell lung cancer (NSCLC) patient, with potential antineoplastic and immunomodulating activities. Upon administration of the NSCLC-specific MILs, the T cells target and destroy the destroy the patient's NSCLC cells."], "t": []}], "preferred_name": "NSCLC-specific Marrow Infiltrating Lymphocytes", "taxa": []}
{"type": "biolink:Cell", "ic": 76.5892103226413, "identifiers": [{"i": "CL:4023054", "l": "mesothelial fibroblast", "d": ["A mesothelial cell that has undergone mesothelial-to-mesenchymal transition (MMT) to become a fibroblast cell."], "t": []}], "preferred_name": "mesothelial fibroblast", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C4745003", "l": "Autologous Anti-BCMA-CAR-mRNA-transfected CD8+ T-lymphocytes", "d": [], "t": []}, {"i": "NCIT:C156706", "l": "Autologous Anti-BCMA-CAR-mRNA-transfected CD8+ T-lymphocytes", "d": ["A preparation of autologous CD8-positive T-lymphocytes that have been genetically modified via transient mRNA transfection to express a chimeric antigen receptor (CAR) specific for the tumor-associated antigen (TAA) human B-cell maturation antigen (BCMA; tumor necrosis factor receptor superfamily member 17; TNFRSF17) and containing, as of yet undisclosed co-stimulatory signaling domains, with potential immunostimulating and antineoplastic activities. Upon administration, autologous anti-BCMA-CAR-mRNA transfected CD8+ T-lymphocytes specifically recognize and induce selective toxicity in BCMA-expressing tumor cells. BCMA, a tumor-specific antigen and a receptor for both a proliferation-inducing ligand (APRIL) and B-cell activating factor (BAFF), is a member of the tumor necrosis factor receptor superfamily (TNFRSF) and plays a key role in plasma cell survival. BCMA is found on the surfaces of plasma cells and overexpressed on malignant plasma cells."], "t": []}], "preferred_name": "Autologous Anti-BCMA-CAR-mRNA-transfected CD8+ T-lymphocytes", "taxa": []}
{"type": "biolink:Cell", "ic": 61.38993037434873, "identifiers": [{"i": "CL:0000210", "l": "photoreceptor cell", "d": ["A cell specialized in detecting light stimuli that are involved in visual perception."], "t": []}, {"i": "UMLS:C0031760", "l": "Photoreceptors", "d": [], "t": []}, {"i": "NCIT:C12634", "l": "Photoreceptor Cell", "d": ["A sensory neuron, located in the retina of the eye, that converts light signals into nerve impulses."], "t": []}, {"i": "MESH:D010786", "l": "Photoreceptor Cells", "d": [], "t": []}], "preferred_name": "photoreceptor cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C3899992", "l": "Autologous TNS9.3.55-transduced CD34-positive Cells", "d": [], "t": []}, {"i": "NCIT:C116734", "l": "Autologous TNS9.3.55-transduced CD34-positive Cells", "d": ["A preparation of autologous, CD34-positive hematopoietic progenitor cells (HPCs) ex vivo transduced with TNS9.3.55, a lentiviral vector encoding the human beta-globin (hemoglobin-beta, HBB) gene, with potential to restore beta-globin expression and function. Autologous CD34-positive stem cells are isolated from the patient's own bone marrow, the deficient HBB gene is removed, and the cells are transduced with the lentiviral vector. Upon re-infusion of the TNS9.3.55-transduced CD34-positive cells back into the patient, these cells express beta-globin, thereby allowing the body to make normal hemoglobin and thus normal, healthy red blood cells. Beta-globin, the beta-chain of the most common form of hemoglobin, is encoded by the HBB gene; mutations in this gene prevent normal beta-globin production."], "t": []}], "preferred_name": "Autologous TNS9.3.55-transduced CD34-positive Cells", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5707273", "l": "Anti-CD19-CAR CMV-specific T-lymphocytes", "d": [], "t": []}, {"i": "NCIT:C187649", "l": "Anti-CD19-CAR CMV-specific T-lymphocytes", "d": ["A preparation of human cytomegalovirus (CMV)-specific T-lymphocytes that have been engineered to express a chimeric antigen receptor (CAR) specific for the human tumor associated antigen (TAA) CD19, with potential immunostimulating and antineoplastic activities. Upon administration, anti-CD19-CAR CMV-specific T-lymphocytes recognize, bind to, and induce selective toxicity in CD19-expressing tumor cells. CD19 is a B-cell specific cell surface antigen overexpressed in B-cell lineage malignancies. The anti-CD19-CAR CMV-specific T-lymphocytes may potentially be expanded in vivo through CMV vaccination."], "t": []}], "preferred_name": "Anti-CD19-CAR CMV-specific T-lymphocytes", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5237260", "l": "Anti-CD19 CAR T-cells XLCART001", "d": [], "t": []}, {"i": "NCIT:C165551", "l": "Anti-CD19 CAR T-cells XLCART001", "d": ["A preparation of T-lymphocytes that have been genetically modified to express a chimeric antigen receptor (CAR) targeting the tumor-associated antigen (TAA) CD19 and containing, as of yet undisclosed co-stimulatory signaling domains, with potential immunostimulating and antineoplastic activities. Upon administration, anti-CD19 CAR T-cells XLCART001 targets and binds to CD19-expressing tumor cells, thereby inducing selective toxicity in CD19-expressing tumor cells. CD19 antigen is a B-cell specific cell surface antigen expressed in all B-cell lineage malignancies."], "t": []}], "preferred_name": "Anti-CD19 CAR T-cells XLCART001", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1522165", "l": "Mouse Mast Cell", "d": [], "t": []}, {"i": "NCIT:C22594", "l": "Mouse Mast Cell", "d": [], "t": []}], "preferred_name": "Mouse Mast Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4023129", "l": "retinoblast", "d": ["A retinal cell that is immature or undifferentiated."], "t": []}], "preferred_name": "retinoblast", "taxa": []}
{"type": "biolink:Cell", "ic": 47.77984995423025, "identifiers": [{"i": "UMLS:C1510725", "l": "Abnormal Hematopoietic and Lymphoid Cell", "d": [], "t": []}, {"i": "NCIT:C36987", "l": "Abnormal Hematopoietic and Lymphoid Cell", "d": [], "t": []}], "preferred_name": "Abnormal Hematopoietic and Lymphoid Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4033005", "l": "serous secreting cell of bronchus submucosal gland", "d": ["A(n) serous secreting cell that is part of a(n) bronchus submucosal gland."], "t": []}], "preferred_name": "serous secreting cell of bronchus submucosal gland", "taxa": []}
{"type": "biolink:Cell", "ic": 67.94889746485862, "identifiers": [{"i": "UMLS:C1514068", "l": "Neoplastic Polygonal Cell", "d": [], "t": []}, {"i": "NCIT:C36851", "l": "Neoplastic Polygonal Cell", "d": [], "t": []}], "preferred_name": "Neoplastic Polygonal Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 68.8717166271425, "identifiers": [{"i": "UMLS:C1266872", "l": "Renal tubular epithelial cell", "d": [], "t": []}, {"i": "NCIT:C61147", "l": "Renal Tubular Epithelial Cell", "d": [], "t": []}, {"i": "SNOMEDCT:117287000", "l": "", "d": [], "t": []}], "preferred_name": "Renal tubular epithelial cell", "taxa": []}
{"type": "biolink:Cell", "ic": 53.582991139942344, "identifiers": [{"i": "UMLS:C1440938", "l": "Immature Lymphocyte", "d": [], "t": []}, {"i": "NCIT:C13118", "l": "Immature Lymphocyte", "d": ["A cell that develops from hematopoietic stem cells. An immature lymphocyte represents of one of five stages of lymphocyte maturation. It is estimated 90% of immature lymphocytes die in the thymus and bone marrow."], "t": []}], "preferred_name": "Immature Lymphocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 83.63771255585968, "identifiers": [{"i": "CL:2000046", "l": "ventricular cardiac muscle cell", "d": ["Any cardiac muscle cell that is part of a cardiac ventricle."], "t": []}], "preferred_name": "ventricular cardiac muscle cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0000759", "l": "type 7 cone bipolar cell (sensu Mus)", "d": ["An ON-bipolar neuron found in the retina and having connections with cone photoreceptors cells and neurons in the inner half of the inner plexiform layer. The axon terminal is narrowly stratified and are found just below a calretinin-expressing band in sublamina 4 of the inner plexiform layer."], "t": []}], "preferred_name": "type 7 cone bipolar cell (sensu Mus)", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C2699753", "l": "TGF-beta-Resistant LMP-Specific Cytotoxic T-Lymphocytes", "d": [], "t": []}, {"i": "NCIT:C77859", "l": "TGF-beta-Resistant LMP-Specific Cytotoxic T-Lymphocytes", "d": ["A preparation of transforming growth factor-beta (TGF-beta)-resistant cytotoxic T-lymphocytes (CTL) reactive to Epstein-Barr virus (EBV) latent membrane proteins 1 and 2 (LMP 1 and 2) with potential antineoplastic activity. T lymphocytes are transduced with a retroviral vector expressing the dominant-negative mutant type II TGF-beta receptor, which blocks signaling by all three TGF-beta isoforms. These TGF-beta-resistant T-lymphocytes are exposed ex-vivo to dendritic cells (DCs) transfected with a replication-deficient adenovirus encoding EBV LMP; subsequent exposure to LMP1- or LMP2-expressing lymphoblastoid cell lines is used to expand the CTL.  Administered to patients with EBV-positive tumors, TGF-beta-resistant LMP-specific CTL target LMP-positive cells, which may result in a specific CTL response, followed by cell lysis and inhibition of tumor cell proliferation. Tumor-expressed TGF-beta inhibits T lymphocyte activation and expansion."], "t": []}], "preferred_name": "TGF-beta-Resistant LMP-Specific Cytotoxic T-Lymphocytes", "taxa": []}
{"type": "biolink:Cell", "ic": 90.871710685482, "identifiers": [{"i": "CL:4033069", "l": "cycling T cell", "d": ["A(n) T cell that is cycling."], "t": []}], "preferred_name": "cycling T cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5157289", "l": "CD127 blasts | Blood | Cell markers", "d": [], "t": []}], "preferred_name": "CD127 blasts | Blood | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:2000076", "l": "hindlimb stylopod vein endothelial cell", "d": ["Any vein endothelial cell that is part of a hindlimb stylopod."], "t": []}], "preferred_name": "hindlimb stylopod vein endothelial cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C0221283", "l": "Drepanocyte (cell)", "d": [], "t": []}, {"i": "NCIT:C36717", "l": "Sickle Cell", "d": ["An abnormal red blood cell with a crescent or C-shape, a result of sickle cell disease."], "t": []}, {"i": "SNOMEDCT:49938009", "l": "", "d": [], "t": []}], "preferred_name": "Drepanocyte (cell)", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C4524461", "l": "Autologous Human Anti-CD19CAR-4-1BB-CD3zeta-EGFRt-expressing CD4+/CD8+ T-lymphocytes", "d": [], "t": []}, {"i": "NCIT:C133191", "l": "Autologous Human Anti-CD19CAR-4-1BB-CD3zeta-EGFRt-expressing CD4+/CD8+ T-lymphocytes", "d": ["A preparation of a defined ratio of CD4+ and bulk CD8+ autologous T-lymphocytes transduced with a lentiviral vector expressing a chimeric antigen receptor (CAR) containing a human anti-CD19 single chain variable fragment (scFv) fused to the signaling domain of 4-1BB (CD137), the zeta chain of the TCR/CD3 complex (CD3-zeta), and a truncated form of the human epidermal growth factor receptor (EGFRt), with potential immunostimulating and antineoplastic activities. Upon intravenous administration, autologous human anti-CD19CAR-4-1BB-CD3zeta-EGFRt-expressing CD4+/CD8+ T-lymphocytes are directed to and induce selective toxicity in CD19-expressing tumor cells. CD19 antigen is a B-cell specific cell surface antigen expressed in all B-cell lineage malignancies. Devoid of both ligand binding domains and tyrosine kinase activity, the expressed EGFRt both facilitates in vivo detection of the administered, transduced T-cells and can promote elimination of those cells through a cetuximab-induced antibody dependent cellular cytotoxicity (ADCC) response. The 4-1BB costimulatory signaling domain enhances both proliferation of T-cells and antitumor activity."], "t": []}], "preferred_name": "Autologous Human Anti-CD19CAR-4-1BB-CD3zeta-EGFRt-expressing CD4+/CD8+ T-lymphocytes", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C4687587", "l": "NY-ESO-1 TCR Retroviral Vector-transduced Autologous PBMCs", "d": [], "t": []}, {"i": "NCIT:C146939", "l": "NY-ESO-1 TCR Retroviral Vector-transduced Autologous PBMCs", "d": ["Human autologous peripheral blood mononuclear cells (PBMCs) transduced with a retroviral vector (RV) encoding a T-cell receptor (TCR) specific for the cancer-testis antigen NY-ESO-1, with potential immunostimulating and antineoplastic activities. Upon isolation, transduction, expansion ex vivo, and reintroduction into the patient, the NY-ESO-1 TCR RV-transduced autologous PBMCs recognize and bind to NY-ESO-1-overexpressing tumor cells. This may result in a specific cytotoxic T-lymphocyte (CTL)-mediated killing of NY-ESO-1-positive tumor cells. NY-ESO-1, a tumor associated antigen (TAA), is found in normal testis and on the surface of various tumor cell types."], "t": []}], "preferred_name": "NY-ESO-1 TCR Retroviral Vector-transduced Autologous PBMCs", "taxa": []}
{"type": "biolink:Cell", "ic": 92.76600187037766, "identifiers": [{"i": "CL:4033087", "l": "placental resident macrophage", "d": ["A tissue-resident macrophage that is part of the placenta. This cell helps preventing immunological rejection of the fetus by modulating the immune environment. A placental resident macrophage has high plasticity to adapt to the changing needs of each phase of pregnancy."], "t": []}], "preferred_name": "placental resident macrophage", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5667007", "l": "Allogeneic NK-like Cells GAIA-102", "d": [], "t": []}, {"i": "NCIT:C185594", "l": "Allogeneic NK-like Cells GAIA-102", "d": ["A preparation of allogeneic, off-the-shelf (OTS), ex-vivo activated and expanded natural killer (NK)-like cells, with a CD3-negative/CD56bright/CD57-negative immature phenotype, with potential cytolytic and antineoplastic activities. Upon infusion, allogeneic NK-like cells GAIA-102 may lyse cancer cells. These cells also secrete pro-inflammatory cytokines, which further stimulate anti-tumor immune responses."], "t": []}], "preferred_name": "Allogeneic NK-like Cells GAIA-102", "taxa": []}
{"type": "biolink:Cell", "ic": 77.38833137893549, "identifiers": [{"i": "CL:1000854", "l": "kidney blood vessel cell", "d": ["A blood vessel cell that is part of a kidney."], "t": []}], "preferred_name": "kidney blood vessel cell", "taxa": []}
{"type": "biolink:Cell", "ic": 90.871710685482, "identifiers": [{"i": "CL:0007005", "l": "notochordal cell", "d": ["Cell that is part of the notochord."], "t": []}], "preferred_name": "notochordal cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5785428", "l": "Allogeneic Ex-vivo-treated Peripheral Blood Mononuclear Cells", "d": [], "t": []}], "preferred_name": "Allogeneic Ex-vivo-treated Peripheral Blood Mononuclear Cells", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "CL:0001018", "l": "immature CD8-alpha-low Langerhans cell", "d": ["Immature CD8-alpha-low Langerhans cell is a CD8-alpha-low Langerhans cell that is CD80-low, CD86-low, and MHCII-low."], "t": []}], "preferred_name": "immature CD8-alpha-low Langerhans cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0002470", "l": "MHC-II-positive classical monocyte", "d": ["Gr1-high monocyte that has a MHC-II receptor complex."], "t": []}], "preferred_name": "MHC-II-positive classical monocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 66.66448812041634, "identifiers": [{"i": "UMLS:C1518175", "l": "Malignant Epithelial Clear Cell", "d": [], "t": []}, {"i": "NCIT:C36784", "l": "Malignant Epithelial Clear Cell", "d": [], "t": []}], "preferred_name": "Malignant Epithelial Clear Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 73.73386095387401, "identifiers": [{"i": "UMLS:C1515428", "l": "Thymic B-Lymphocyte", "d": [], "t": []}, {"i": "NCIT:C38329", "l": "Thymic B-Lymphocyte", "d": ["A white blood cell derived from bone marrow precursors which lack any T cell markers. It can give rise to either thymic cortical and medullary progeny, or medullary progeny alone."], "t": []}], "preferred_name": "Thymic B-Lymphocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0009087", "l": "fused extravillous trophoblast", "d": ["An extravillous trophoblast that is polynuclear."], "t": []}], "preferred_name": "fused extravillous trophoblast", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C2951083", "l": "Set of interneurons of gray matter of spinal cord", "d": [], "t": []}], "preferred_name": "Set of interneurons of gray matter of spinal cord", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5706663", "l": "exagamglogene autotemcel", "d": [], "t": []}, {"i": "MESH:C000729927", "l": "", "d": [], "t": []}, {"i": "SNOMEDCT:43170711000001108", "l": "", "d": [], "t": []}], "preferred_name": "exagamglogene autotemcel", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5959760", "l": "Allogeneic Calibrated Release IL-15-expressing Logic-Gated Gene Circuit Anti-CD33/FLT3 CAR-NK Cells SENTI-202", "d": [], "t": []}, {"i": "NCIT:C206380", "l": "Allogeneic Calibrated Release IL-15-expressing Logic-Gated Gene Circuit Anti-CD33/FLT3 CAR-NK Cells SENTI-202", "d": ["A preparation of off-the-shelf (OTS) natural killer (NK) cells engineered to express three chimeric proteins: 1) a bivalent activating chimeric antigen receptor (aCAR), controlled by OR logic gated gene circuit, specific for the tumor-associated antigens (TAAs) cluster of differentiation 33 (CD33) and FLT3 tyrosine kinase receptor (Fms-like tyrosine kinase 3; FLT3; FLT-3; CD135; fetal liver kinase-2; FLK2) (CD33 OR FLT3 (OR GATE) aCAR), 2) an inhibitory CAR (iCAR) recognizing endomucin (EMCN) and controlled by NOT logic gate (NOT EMCN (NOT GATE) iCAR), and 3) a calibrated release interleukin 15 (IL-15) (crIL15), with potential immunostimulating and antineoplastic activities. Upon administration, the allogeneic crIL-15-expressing logic-gated gene circuit anti-CD33/FLT3 CAR-NK cells SENTI-202 targets and binds to CD33 and/or FLT3 expressed on the surface of tumor cells, such as primary acute myeloid leukemia (AML) blasts and leukemic stem cells (LSCs). This induces selective toxicity in tumor cells expressing CD33 and/or FLT3. To protect CD33/FLT3-expressing healthy hematopoietic stem cells (HSCs) from potential aCAR-mediated on-target/off-tumor toxicity, the iCAR recognizes and binds to the healthy cell surface protein EMCN, which is selectively expressed on healthy HSCs but absent on tumor cells. The crIL-15 allows for activation of the IL-15 receptor pathway, which increases the persistence, activation and killing activity of SENTI-202 and other immune cells. CD33 and FLT3 are expressed on healthy HSCs and on a variety of cancer cells."], "t": []}], "preferred_name": "Allogeneic Calibrated Release IL-15-expressing Logic-Gated Gene Circuit Anti-CD33/FLT3 CAR-NK Cells SENTI-202", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0002026", "l": "CD34-negative, CD41-positive, CD42-positive megakaryocyte cell", "d": ["A megakaryocyte progenitor cell that is CD34-negative, CD41-positive and CD42-positive."], "t": []}], "preferred_name": "CD34-negative, CD41-positive, CD42-positive megakaryocyte cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1517639", "l": "KA09", "d": [], "t": []}, {"i": "NCIT:C20269", "l": "KA09", "d": ["Provider: Karolinska Institute, Stockholm, Sweden. No information from provider. This cell line meets the criteria for the use of human embryonic stem cells by federally funded researchers."], "t": []}], "preferred_name": "KA09", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5549357", "l": "Normoblasts.total", "d": [], "t": []}], "preferred_name": "Normoblasts.total", "taxa": []}
{"type": "biolink:Cell", "ic": 92.76600187037766, "identifiers": [{"i": "CL:0002516", "l": "interrenal chromaffin cell", "d": ["A chromaffin cell interspersed among the interrenal epithelial layer of the anterior kidney of teloest fish."], "t": []}], "preferred_name": "interrenal chromaffin cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4518172", "l": "Population of all fetal erythrocytes in portion of fluid", "d": [], "t": []}, {"i": "SNOMEDCT:725441003", "l": "", "d": [], "t": []}], "preferred_name": "Population of all fetal erythrocytes in portion of fluid", "taxa": []}
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{"type": "biolink:Cell", "ic": 68.7561931576626, "identifiers": [{"i": "CL:4023154", "l": "myelinating glial cell", "d": ["A glial cell that myelinates axonal processes."], "t": []}], "preferred_name": "myelinating glial cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1267938", "l": "Lymphocyte positive for CD49C antigen", "d": [], "t": []}, {"i": "SNOMEDCT:117381002", "l": "", "d": [], "t": []}], "preferred_name": "Lymphocyte positive for CD49C antigen", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5204815", "l": "Alpha/beta T-cell/CD19+ B-cell-depleted Unrelated or Partially Matched Donor-derived Allogeneic Peripheral Blood Stem Cells", "d": [], "t": []}, {"i": "NCIT:C159940", "l": "Alpha/beta T-cell/CD19+ B-cell-depleted Unrelated or Partially Matched Donor-derived Allogeneic Peripheral Blood Stem Cells", "d": ["A preparation of allogeneic peripheral blood stem cells (PBSCs) from an unrelated or partially matched related donor that have been selectively depleted of alpha/beta T-cells and CD19-positive (CD19+) B-cells with potential immune reconstituting activity. The alpha/beta T-cell/CD19+ B-cell-depleted stem cells contain high amounts of natural killer (NK) cells, gamma/delta T-cells, CD34+ stem cells, and dendritic cells (DCs), while devoid of alpha/beta T-cells and CD19-positive B-cells. Depletion of alpha/beta T-cells, which are implicated in the adaptive immune response that mediates graft-versus-host disease (GvHD), may promote rapid and sustained engraftment, immune reconstitution, and may prevent or reduce the development of GvHD. The depletion of CD19+ B-cells may reduce the risk of Epstein-Barr virus (EBV)-driven post-transplant lymphoproliferative disorders. The retained CD3+ gamma/delta T-cells and NK cells may synergistically exert an anti-leukemic and antiviral effector function, which may further promote engraftment and immune reconstitution."], "t": []}], "preferred_name": "Alpha/beta T-cell/CD19+ B-cell-depleted Unrelated or Partially Matched Donor-derived Allogeneic Peripheral Blood Stem Cells", "taxa": []}
{"type": "biolink:Cell", "ic": 63.48684274192801, "identifiers": [{"i": "CL:0002078", "l": "meso-epithelial cell", "d": ["Epithelial cell derived from mesoderm or mesenchyme."], "t": []}, {"i": "UMLS:C1181295", "l": "Meso-epithelial cell", "d": [], "t": []}], "preferred_name": "meso-epithelial cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1513938", "l": "Neoplastic Chondroblast-Like Cell", "d": [], "t": []}, {"i": "NCIT:C36986", "l": "Neoplastic Chondroblast-Like Cell", "d": [], "t": []}], "preferred_name": "Neoplastic Chondroblast-Like Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1518115", "l": "MB03", "d": [], "t": []}, {"i": "NCIT:C20277", "l": "MB03", "d": ["Provider: Maria Biotech Co. Ltd. - Maria Infertility Hospital Medical Institute, Seoul, Korea. Information from provider and not independently verified by NIH: Cells are positive for cell markers SSEA-3, SSEA-4, Oct-4, alkaline phosphatase activity and telomerase activity; Cells are negative for the cell marker SSEA-1; Cell has normal karyotype (46 XX); Differentiation in vitro into neuron; Cells were cultured in feeder-free culture condition using Matrigel coated plate. This cell line meets the criteria for the use of human embryonic stem cells by federally funded researchers."], "t": []}], "preferred_name": "MB03", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1510964", "l": "Atypical Spindle Melanocyte", "d": [], "t": []}, {"i": "NCIT:C36868", "l": "Atypical Spindle Melanocyte", "d": [], "t": []}], "preferred_name": "Atypical Spindle Melanocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4072006", "l": "A9 dopaminergic neuron", "d": ["A type of dopaminergic neuron in the substantia nigra involved in motor control and particularly vulnerable in Parkinson’s disease. In mice, it is notable for its heterogeneous co-release of dopamine with either glutamate or GABA. It releases GABA through alternative synthesis pathways or reuptake mechanisms independent of GAD expression."], "t": []}], "preferred_name": "A9 dopaminergic neuron", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5555777", "l": "Autologous Anti-B7-H3 CAR T Cells", "d": [], "t": []}, {"i": "NCIT:C179567", "l": "Autologous Anti-B7-H3 CAR T Cells", "d": ["A preparation of autologous T-lymphocytes that have been genetically engineered to express a chimeric antigen receptor (CAR) targeting the immunoregulatory protein B7-homologue 3 (B7-H3, CD276) and containing, as of yet undisclosed co-stimulatory signaling domains, with potential immunostimulating and antineoplastic activities. Upon infusion back into the patient, autologous anti-B7-H3 CAR T cells target and bind to B7-H3-expressing tumor cells, thereby inducing selective toxicity in B7-H3-expressing tumor cells. B7-H3, a type I transmembrane protein and a member of the B7 co-stimulatory protein superfamily, is overexpressed on certain tumor cell types and on various immune cells. It is a negative regulator of the T-cell activation and its overexpression plays a key role in tumor cell invasion and metastasis."], "t": []}], "preferred_name": "Autologous Anti-B7-H3 CAR T Cells", "taxa": []}
{"type": "biolink:Cell", "ic": 90.871710685482, "identifiers": [{"i": "UMLS:C1882061", "l": "Neoplastic Small Sex Cord-Stromal Cell", "d": [], "t": []}, {"i": "NCIT:C61425", "l": "Neoplastic Small Sex Cord-Stromal Cell", "d": [], "t": []}], "preferred_name": "Neoplastic Small Sex Cord-Stromal Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 52.822688810319434, "identifiers": [{"i": "UMLS:C1513951", "l": "Neoplastic Endocrine Cell", "d": [], "t": []}, {"i": "NCIT:C36925", "l": "Neoplastic Endocrine Cell", "d": [], "t": []}], "preferred_name": "Neoplastic Endocrine Cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0596630", "l": "granule cell", "d": [], "t": []}], "preferred_name": "granule cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C0085080", "l": "Chinese Hamster Ovary Cell", "d": [], "t": []}, {"i": "NCIT:C17421", "l": "CHO Cells", "d": ["The parental CHO cell line initiated from a biopsy of an ovary of an adult Chinese hamster."], "t": []}, {"i": "MESH:D016466", "l": "CHO Cells", "d": [], "t": []}], "preferred_name": "Chinese Hamster Ovary Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C4725930", "l": "Autologous Ovarian Cancer Immunogene-modified T Lymphocytes", "d": [], "t": []}, {"i": "NCIT:C150696", "l": "Autologous Ovarian Cancer Immunogene-modified T Lymphocytes", "d": ["A preparation of autologous immunogene modified T-lymphocytes (IgT) that have been genetically engineered to be specifically reactive to ovarian cancer (OC) cells, with potential antineoplastic and immunostimulating activities. Upon administration of the autologous OC-IgT cells, the T-cells recognize and induce specific toxicity in the OC cells."], "t": []}], "preferred_name": "Autologous Ovarian Cancer Immunogene-modified T Lymphocytes", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1519720", "l": "Type I Epithelial Receptor Cell", "d": [], "t": []}, {"i": "NCIT:C33824", "l": "Type I Epithelial Receptor Cell", "d": ["A dark cell found in taste buds. It is rich in free ribosomes, tubular RER and has large dense granules and exhibits AbH immunoreactivity."], "t": []}], "preferred_name": "Type I Epithelial Receptor Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 78.05853671694304, "identifiers": [{"i": "CL:0000494", "l": "UV sensitive photoreceptor cell", "d": ["A photoreceptor cell that detects ultraviolet light."], "t": []}], "preferred_name": "UV sensitive photoreceptor cell", "taxa": []}
{"type": "biolink:Cell", "ic": 57.210963867825484, "identifiers": [{"i": "CL:0000355", "l": "multi-potent skeletal muscle stem cell", "d": ["A multifate stem cell found in skeletal muscle than can differentiate into many different cell types, including muscle. Distinct cell type from satellite cell."], "t": []}], "preferred_name": "multi-potent skeletal muscle stem cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C2329995", "l": "Stratified amacrine cell of retina", "d": [], "t": []}], "preferred_name": "Stratified amacrine cell of retina", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0002189", "l": "granular cell of epidermis", "d": ["A keratinocyte located in the stratum granulosum of the epidermis, characterized by the presence of keratohyalin granules containing filaggrin—which aggregate keratin filament —and by lamellar granules that secrete lipids and enzymes essential for forming the skin’s waterproof barrier. As these cells progress toward the surface, they adopt a flattened morphology and initiate keratinization to become corneocyte and form the protective stratum corneum. In human epidermis, granular keratinocytes are transcriptomically distinguished by high expression of differentiation markers such as DSC1, KRT2, IVL, and TGM3 (Wang et al., 2020), and LOR, FLG, and SPINK5 (Cheng et al., 2018)."], "t": []}, {"i": "UMLS:C1182606", "l": "Granular cell of epidermis", "d": [], "t": []}], "preferred_name": "granular cell of epidermis", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5157319", "l": "CD15 blasts | XXX | Cell markers", "d": [], "t": []}], "preferred_name": "CD15 blasts | XXX | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5856157", "l": "Anti-mesothelin CAR-CD40L-expressing T-lymphocytes", "d": [], "t": []}, {"i": "NCIT:C200193", "l": "Anti-mesothelin CAR-CD40L-expressing T-lymphocytes", "d": ["A preparation of T-lymphocytes that have been genetically modified to express a chimeric antigen receptor (CAR) specific for the human tumor-associated antigen (TAA) mesothelin (MSLN), and CD40 ligand (CD40L; CD154; TRAP; TNFSF5), with potential immunomodulating and antineoplastic activities. Upon administration, anti-MSLN CAR-CD40L-expressing T-lymphocytes specifically target and kill MSLN-expressing tumor cells. Mesothelin, a cell surface glycoprotein involved in cell adhesion, is overexpressed in a variety of cancer cell types. CD40L binds to CD40 and activates CD40/CD40L-mediated signaling, which activates monocyte-derived dendritic cells (moDCs), increases the secretion of inflammatory cytokines and further stimulates cytotoxic T-lymphocytes (CTLs). This enhances cytotoxicity and anti-tumor immune response."], "t": []}], "preferred_name": "Anti-mesothelin CAR-CD40L-expressing T-lymphocytes", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0020031", "l": "CD8-positive exhausted alpha-beta T cell", "d": ["A CD8-positive alpha-beta T cell that displays impaired function and altered differentiation as a result of chronic antigenic stimulation (e.g., chronic infection, tumours, or persistent inflammation). This state is characterised by sustained expression of PD-1 as a shared feature. Additional exhaustion-associated molecules, including expression of the transcription factor TOX and reduced T-bet, and context- or stage-dependent changes in markers such as LAG-3, TIM-3, CD39, and EOMES, may also be observed; however, the expression levels of these molecules vary depending on exhaustion stage and disease context."], "t": []}], "preferred_name": "CD8-positive exhausted alpha-beta T cell", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "CL:0009092", "l": "endothelial cell of placenta", "d": ["An endothelial cell that is part of a placenta."], "t": []}], "preferred_name": "endothelial cell of placenta", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1516944", "l": "Epithelial Reticular Cell", "d": [], "t": []}, {"i": "NCIT:C13124", "l": "Epithelial Reticular Cell", "d": ["A branched epithelial cell that supports epithelial structures."], "t": []}], "preferred_name": "Epithelial Reticular Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "CL:1000001", "l": "retrotrapezoid nucleus neuron", "d": ["Any neuron that has its soma located in some retrotrapezoid nucleus."], "t": []}], "preferred_name": "retrotrapezoid nucleus neuron", "taxa": []}
{"type": "biolink:Cell", "ic": 69.67647926784257, "identifiers": [{"i": "CL:0000014", "l": "germ line stem cell", "d": ["A stem cell that is the precursor of gametes."], "t": []}], "preferred_name": "germ line stem cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C4329516", "l": "CD8+NKG2D+ AKT Cell", "d": [], "t": []}, {"i": "NCIT:C132027", "l": "CD8+NKG2D+ AKT Cell", "d": ["A preparation of human CD8-positive tumor-specific T-lymphocytes engineered to express the natural killer cell activating receptor group 2D (NKG2D) and the serine/threonine kinase AKT, with potential immunomodulating and antineoplastic activities. Upon administration of CD8+NKG2D+ AKT cells, these cells target and kill tumor cells. AKT-mediated signaling enhances the activation, differentiation, proliferation and cytokine production of tumor specific T-cells, which enhances their anti-tumor effects; AKT activity in T-cells is often downregulated in the tumor environment. NKG2D, a stimulatory lymphocyte receptor, mediates the recognition of tumors cells and promotes T-cell activation and T-cell-mediated tumor cell killing; NKG2D ligands are expressed on cancer cells, while they are minimally expressed by or absent from normal, healthy cells."], "t": []}], "preferred_name": "CD8+NKG2D+ AKT Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 67.94889746485862, "identifiers": [{"i": "UMLS:C1708871", "l": "Malignant Endothelial Cell", "d": [], "t": []}, {"i": "NCIT:C47834", "l": "Malignant Endothelial Cell", "d": [], "t": []}], "preferred_name": "Malignant Endothelial Cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C6021825", "l": "Cells.CD200+CD19+", "d": [], "t": []}], "preferred_name": "Cells.CD200+CD19+", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5780010", "l": "PLX RAD", "d": [], "t": []}], "preferred_name": "PLX RAD", "taxa": []}
{"type": "biolink:Cell", "ic": 89.40238429118027, "identifiers": [{"i": "UMLS:C0014762", "l": "Erythroblasts", "d": [], "t": []}, {"i": "NCIT:C12527", "l": "Erythroblast", "d": ["An immature, nucleated erythrocyte occupying the stage of erythropoiesis that follows formation of erythroid progenitor cells and precedes formation of reticulocytes."], "t": []}, {"i": "NCIT:C73125", "l": "Nucleated Red Blood Cell", "d": ["Red blood cells that are at the last stage of development, still containing a nucleus, that are found in the bone marrow and occasionally in the peripheral blood."], "t": []}, {"i": "MESH:D004900", "l": "Erythroblasts", "d": [], "t": []}, {"i": "SNOMEDCT:29208003", "l": "", "d": [], "t": []}, {"i": "SNOMEDCT:84227004", "l": "", "d": [], "t": []}], "preferred_name": "Erythroblasts", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5180578", "l": "Segmented neutrophils | Pleural fluid | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Segmented neutrophils | Pleural fluid | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": 82.16838616155795, "identifiers": [{"i": "CL:4300363", "l": "ependymal cell (Mmus)", "d": ["A ependymal cell of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Tmem212 (Mmus), Rarres2 (Mmus). Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Subclass:323 Ependymal NN."], "t": []}], "preferred_name": "ependymal cell (Mmus)", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0009045", "l": "B cell of medullary sinus of lymph node", "d": ["A B cell found in the lymph node medullary sinus."], "t": []}], "preferred_name": "B cell of medullary sinus of lymph node", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1441346", "l": "1000 erythrocytes", "d": [], "t": []}], "preferred_name": "1000 erythrocytes", "taxa": []}
{"type": "biolink:Cell", "ic": 80.96785908349635, "identifiers": [{"i": "CL:0002620", "l": "skin fibroblast", "d": ["A fibroblast of skin."], "t": []}], "preferred_name": "skin fibroblast", "taxa": []}
{"type": "biolink:Cell", "ic": 86.30756602822301, "identifiers": [{"i": "UMLS:C1517536", "l": "Geron ES Cell Line", "d": [], "t": []}, {"i": "NCIT:C20255", "l": "Geron ES Cell Line", "d": [], "t": []}], "preferred_name": "Geron ES Cell Line", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0882795", "l": "CD15+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:1372849001", "l": "", "d": [], "t": []}], "preferred_name": "CD15+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5554960", "l": "Anti-Claudin18.2 CAR T Cells LCAR-C18S", "d": [], "t": []}, {"i": "NCIT:C178335", "l": "Anti-Claudin18.2 CAR T Cells LCAR-C18S", "d": ["A preparation of T-lymphocytes engineered to express a chimeric antigen receptor (CAR) specific for the tumor-associated antigen (TAA) Claudin18.2 (CLDN18.2; A2 isoform of claudin-18), with potential immunostimulating and antineoplastic activities. Upon administration, anti-Claudin18.2 CAR T cells LCAR-C18S specifically recognize and induce selective toxicity in CLDN18.2-expressing tumor cells. CLDN18.2, a tight junction protein, is expressed on a variety of tumor cells, but its expression in healthy tissues is strictly confined to short-lived differentiated epithelial cells of the gastric mucosa."], "t": []}], "preferred_name": "Anti-Claudin18.2 CAR T Cells LCAR-C18S", "taxa": []}
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{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0009078", "l": "thymic fibroblast type 1", "d": ["A fibroblast located in the thymic capsule."], "t": []}], "preferred_name": "thymic fibroblast type 1", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C2924459", "l": "Lymphocytes.variant", "d": [], "t": []}], "preferred_name": "Lymphocytes.variant", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4052067", "l": "seromucous acinar cell of salivary gland", "d": ["An acinar cell of the salivary gland, with a hybrid seromucous phenotype, co-expressing serous and mucous markers and producing a mixed secretion of enzymes-containing serous fluid and mucins essential for lubrication, digestion, and antimicrobial defense. Predominant in the submandibular glands of humans and mice, its differentiation and secretory gene expression are regulated by FGFR2b–MAPK signaling, driven by paracrine FGF7 from adjacent myoepithelial cells, which provides a key niche signal for seromucous identity."], "t": []}], "preferred_name": "seromucous acinar cell of salivary gland", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0333816", "l": "Hypersegmented leukocyte", "d": [], "t": []}, {"i": "SNOMEDCT:24481008", "l": "", "d": [], "t": []}], "preferred_name": "Hypersegmented leukocyte", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C6021827", "l": "CD19-CD3-CD56+ (NK)", "d": [], "t": []}], "preferred_name": "CD19-CD3-CD56+ (NK)", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4324226", "l": "CD43+ B lymphocyte", "d": [], "t": []}], "preferred_name": "CD43+ B lymphocyte", "taxa": []}
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{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5398046", "l": "brexucabtagene autoleucel", "d": [], "t": []}, {"i": "MESH:C000705347", "l": "brexucabtagene autoleucel", "d": [], "t": []}, {"i": "SNOMEDCT:895363000", "l": "", "d": [], "t": []}, {"i": "SNOMEDCT:895369001", "l": "", "d": [], "t": []}], "preferred_name": "brexucabtagene autoleucel", "taxa": []}
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{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5157563", "l": "CD41a cells | Blood | Cell markers", "d": [], "t": []}], "preferred_name": "CD41a cells | Blood | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": 78.80476858236055, "identifiers": [{"i": "CL:0008046", "l": "extrafusal muscle fiber", "d": ["A skeletal muscle fiber that is innervated by alpha motor neuron and generates tension by contracting, thereby allowing for skeletal movement. These fibers make up the large mass of skeletal muscle tissue and are attached to bones by tendons."], "t": []}], "preferred_name": "extrafusal muscle fiber", "taxa": []}
{"type": "biolink:Cell", "ic": 87.18682603146104, "identifiers": [{"i": "UMLS:C1881768", "l": "Melanoma Cell with Large Nucleus and Abundant Pale Cytoplasm", "d": [], "t": []}, {"i": "NCIT:C62342", "l": "Melanoma Cell with Large Nucleus and Abundant Pale Cytoplasm", "d": [], "t": []}], "preferred_name": "Melanoma Cell with Large Nucleus and Abundant Pale Cytoplasm", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4704950", "l": "Adipose-Derived Mesenchymal Stem Cells", "d": [], "t": []}], "preferred_name": "Adipose-Derived Mesenchymal Stem Cells", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0000744", "l": "columnar chondrocyte", "d": ["A columnar chondrocyte that differentiates in the late embryonic growth plate of bone. Columnar chondrocytes vigorously proliferate and form columns in the growth plate."], "t": []}], "preferred_name": "columnar chondrocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5985052", "l": "Adherent Cell Line", "d": [], "t": []}, {"i": "NCIT:C213642", "l": "Adherent Cell Line", "d": ["A cell line that propagates as a monolayer attached to the surface of a culture vessel."], "t": []}], "preferred_name": "Adherent Cell Line", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1267860", "l": "Lymphocyte positive for CD9 antigen", "d": [], "t": []}, {"i": "SNOMEDCT:117542003", "l": "", "d": [], "t": []}], "preferred_name": "Lymphocyte positive for CD9 antigen", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1511440", "l": "CH02", "d": [], "t": []}, {"i": "NCIT:C20286", "l": "CH02", "d": ["Provider: Pochon CHA University, Seoul, Korea. No information from provider. This cell line meets the criteria for the use of human embryonic stem cells by federally funded researchers."], "t": []}], "preferred_name": "CH02", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0001048", "l": "activated CD4-positive, CD25-positive, CCR4-positive, alpha-beta regulatory T cell, human", "d": ["A CD4-positive, CD25-positive, CCR4-positive, alpha-beta T regulatory cell with the phenotype HLA-DRA-positive, indicating recent activation."], "t": []}], "preferred_name": "activated CD4-positive, CD25-positive, CCR4-positive, alpha-beta regulatory T cell, human", "taxa": []}
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{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C2717940", "l": "Hep G2 Cells", "d": [], "t": []}, {"i": "MESH:D056945", "l": "Hep G2 Cells", "d": [], "t": []}], "preferred_name": "Hep G2 Cells", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5157253", "l": "CD11+CD20+ cells | White blood cells | Cell markers", "d": [], "t": []}], "preferred_name": "CD11+CD20+ cells | White blood cells | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4023110", "l": "amygdala pyramidal neuron", "d": ["A pyramidal neuron with soma located in the amygdala."], "t": []}], "preferred_name": "amygdala pyramidal neuron", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4055426", "l": "autologous anti-NY-ESO-1/LAGE-1 TCR-transduced c259 T lymphocytes", "d": [], "t": []}], "preferred_name": "autologous anti-NY-ESO-1/LAGE-1 TCR-transduced c259 T lymphocytes", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5786913", "l": "Allogeneic Gamma Delta T-cells GDKM-100", "d": [], "t": []}, {"i": "NCIT:C198221", "l": "Allogeneic Gamma Delta T-cells GDKM-100", "d": ["A preparation of a subset of allogeneic T-lymphocytes that express only gamma chain and delta chain T-cell receptors (TCRs), with potential immunomodulating and antineoplastic activities. Upon administration of the allogeneic gamma delta T-cells GDKM-100, these cells secrete interferon-gamma (IFN-g) and exert direct killing of tumor cells. In addition, these cells activate the immune system to exert a cytotoxic T-lymphocyte (CTL) response against tumor cells. Gamma delta T-lymphocytes play a key role in the activation of the immune system and do not require major histocompatibility complex (MHC)-mediated antigen presentation to exert their cytotoxic effect."], "t": []}], "preferred_name": "Allogeneic Gamma Delta T-cells GDKM-100", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C2331102", "l": "Olfactory glial cell", "d": [], "t": []}], "preferred_name": "Olfactory glial cell", "taxa": []}
{"type": "biolink:Cell", "ic": 82.62268137420203, "identifiers": [{"i": "UMLS:C0333738", "l": "Fat-laden macrophage", "d": [], "t": []}, {"i": "NCIT:C36833", "l": "Lipid-Laden Macrophage", "d": [], "t": []}, {"i": "SNOMEDCT:13901007", "l": "", "d": [], "t": []}], "preferred_name": "Fat-laden macrophage", "taxa": []}
{"type": "biolink:Cell", "ic": 74.24062392510156, "identifiers": [{"i": "CL:0002496", "l": "intraepithelial lymphocyte", "d": ["A tissue-resident lymphocyte located within the epithelial layer of mucosal tissues, particularly within the gastrointestinal, respiratory, and reproductive tracts. Characterised by permanent residency, this cell typically expresses CD103 (integrin alpha-E), which binds to E-cadherin on epithelial cells, enabling epithelial retention in both mice and humans. Phenotypically, IEL displays an activated, antigen-experienced state characterised by the constitutive expression of cytotoxic molecules (granzyme B, perforin) and innate-like receptors (such as NKG2D), enabling rapid, localised surveillance and immediate response to epithelial stress."], "t": []}], "preferred_name": "intraepithelial lymphocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 88.20185721311867, "identifiers": [{"i": "UMLS:C0333741", "l": "Touton giant cell", "d": [], "t": []}, {"i": "NCIT:C36732", "l": "Touton Giant Cell", "d": [], "t": []}, {"i": "SNOMEDCT:71203006", "l": "", "d": [], "t": []}], "preferred_name": "Touton giant cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C2984196", "l": "Therapeutic Allogeneic Cytotoxic T-Lymphocytes", "d": [], "t": []}, {"i": "NCIT:C91374", "l": "Therapeutic Allogeneic Cytotoxic T-Lymphocytes", "d": ["A population of cytotoxic T-lymphocytes (CTLs) that are therapeutically administered to a recipient individual who is genetically distinct from a donor of the same species."], "t": []}], "preferred_name": "Therapeutic Allogeneic Cytotoxic T-Lymphocytes", "taxa": []}
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{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C0282639", "l": "HT29 Cells", "d": [], "t": []}, {"i": "NCIT:C17896", "l": "HT29", "d": ["An adenocarcinoma cell line established from a 44 year old Caucasian female patient with colon carcinoma."], "t": []}, {"i": "MESH:D019073", "l": "HT29 Cells", "d": [], "t": []}], "preferred_name": "HT29 Cells", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5239343", "l": "Autologous Anti-B7-H3 CAR Retroviral Vector-transduced T Cells", "d": [], "t": []}, {"i": "NCIT:C169051", "l": "Autologous Anti-B7-H3 CAR Retroviral Vector-transduced T Cells", "d": ["A preparation of autologous T-lymphocytes that have been transduced with a retroviral vector expressing a chimeric antigen receptor (CAR) targeting the immunoregulatory protein B7-homologue 3 (B7-H3, CD276) and containing, as of yet undisclosed co-stimulatory signaling domains, with potential immunostimulating and antineoplastic activities. Upon infusion back into the patient, autologous anti-B7-H3 CAR retroviral vector-transduced T cells target and bind to B7-H3-expressing tumor cells, thereby inducing selective toxicity in B7-H3-expressing tumor cells. B7-H3, a type I transmembrane protein and a member of the B7 co-stimulatory protein superfamily, is overexpressed on certain tumor cell types and on various immune cells. It is a negative regulator of the T-cell activation and its overexpression plays a key role in tumor cell invasion and metastasis."], "t": []}], "preferred_name": "Autologous Anti-B7-H3 CAR Retroviral Vector-transduced T Cells", "taxa": []}
{"type": "biolink:Cell", "ic": 89.40238429118027, "identifiers": [{"i": "CL:4301593", "l": "Astro-TE NN_3 astrocyte (Mmus)", "d": ["A astrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Gja1 (Mmus), Grin2c (Mmus), Dcc (Mmus), Slc7a10 (Mmus). Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Supertype:1163 Astro-TE NN_3."], "t": []}], "preferred_name": "Astro-TE NN_3 astrocyte (Mmus)", "taxa": []}
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{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1267883", "l": "Lymphocyte positive for CD17 antigen", "d": [], "t": []}, {"i": "SNOMEDCT:117560003", "l": "", "d": [], "t": []}], "preferred_name": "Lymphocyte positive for CD17 antigen", "taxa": []}
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{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5833282", "l": "CD3 cells | Donor | Cell markers", "d": [], "t": []}], "preferred_name": "CD3 cells | Donor | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4033045", "l": "lung migratory dendritic cell", "d": ["A dendritic cell that captures antigens in a lung and migrates to a lymph node or to the spleen to activate T cells."], "t": []}], "preferred_name": "lung migratory dendritic cell", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "CL:0002347", "l": "CD27-high, CD11b-high natural killer cell, mouse", "d": ["A mature natural killer cell that is CD27-high and CD11b-high. This cell type is capable of interferon-gamma secretion."], "t": []}], "preferred_name": "CD27-high, CD11b-high natural killer cell, mouse", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4310143", "l": "ZI-HTH GABA GABAergic interneuron (Primate)", "d": ["A GABAergic interneuron of the Primates brain. These cells are located in the substantia nigra . Reference transcriptomic data for this type can be found in the dataset/taxonomy - HMBA Basal Ganglia Consensus Taxonomy in cell set Group:ZI-HTH GABA."], "t": []}], "preferred_name": "ZI-HTH GABA GABAergic interneuron (Primate)", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "CL:0002093", "l": "secondary polar body", "d": ["A small cell formed by the second meiotic division of oocytes. In mammals, the second polar body may fail to form unless the ovum has been penetrated by a sperm cell."], "t": []}, {"i": "UMLS:C0227884", "l": "Second polar body", "d": [], "t": []}, {"i": "SNOMEDCT:64904008", "l": "", "d": [], "t": []}], "preferred_name": "secondary polar body", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1515989", "l": "Angioblast", "d": [], "t": []}, {"i": "NCIT:C33934", "l": "Angioblast", "d": ["A pluripotent cell that can develop into a vascular endothelial cell."], "t": []}], "preferred_name": "Angioblast", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4030056", "l": "umbrella cell of urothelium", "d": ["A urothelial cell that is terminally differentiated and part of the urothelial apical surface that forms the high-resistance barrier of urothelium. Umbrella cells have been described as the largest of urothelial cell types, highly polarized, and, in some species, multinucleated. In the relaxed state, these cells form a dome-shaped structure at the apical pole and can also cover multiple underlying intermediate cells, leading to the name umbrella cells. In contrast, these cells flatten when the bladder is filled."], "t": []}], "preferred_name": "umbrella cell of urothelium", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0004237", "l": "fountain amacrine cell", "d": ["A retinal amacrine cell with a medium dendritic field and post-synaptic terminals in S1, S2, S3, and S4. This cell type releases the neurotransmitter gamma-aminobutyric acid (GABA)."], "t": []}], "preferred_name": "fountain amacrine cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1883178", "l": "Subclone", "d": [], "t": []}, {"i": "NCIT:C62037", "l": "Subclone", "d": ["A DNA clone generated by transferring a cloned DNA fragment from one plasmid to another."], "t": []}], "preferred_name": "Subclone", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4733097", "l": "PG13-CD19-H3 (anti-CD19 CAR) retroviral vector-transduced peripheral blood lymphocytes", "d": [], "t": []}], "preferred_name": "PG13-CD19-H3 (anti-CD19 CAR) retroviral vector-transduced peripheral blood lymphocytes", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4284514", "l": "Cells.chromosome region 17p13.1", "d": [], "t": []}], "preferred_name": "Cells.chromosome region 17p13.1", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1440310", "l": "CD42c+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:1372888004", "l": "", "d": [], "t": []}], "preferred_name": "CD42c+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": 90.871710685482, "identifiers": [{"i": "UMLS:C0009013", "l": "Clone Cells", "d": [], "t": []}, {"i": "NCIT:C16441", "l": "Cell Clone", "d": ["A population of genetically identical cells derived by mitosis from a single progenitor."], "t": []}, {"i": "MESH:D002999", "l": "Clone Cells", "d": [], "t": []}, {"i": "SNOMEDCT:47308002", "l": "", "d": [], "t": []}], "preferred_name": "Clone Cells", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4038496", "l": "Cells.aneuploid.G2 phase population 2", "d": [], "t": []}], "preferred_name": "Cells.aneuploid.G2 phase population 2", "taxa": []}
{"type": "biolink:Cell", "ic": 65.91676802607104, "identifiers": [{"i": "CL:0000911", "l": "effector T cell", "d": ["A differentiated T cell with ability to traffic to peripheral tissues and is capable of mounting a specific immune response."], "t": []}], "preferred_name": "effector T cell", "taxa": []}
{"type": "biolink:Cell", "ic": 92.76600187037766, "identifiers": [{"i": "CL:0002340", "l": "luminal cell of prostate epithelium", "d": ["The exocrine cell of the prostate, this epithelial cell secretes prostatic acid phosphotase and PSA, and is dependent on androgen hormones for survival."], "t": []}], "preferred_name": "luminal cell of prostate epithelium", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5206845", "l": "Autologous Anti-CD19 CAR-CD28 T-cells ET019002", "d": [], "t": []}, {"i": "NCIT:C162856", "l": "Autologous Anti-CD19 CAR-CD28 T-cells ET019002", "d": ["A preparation of autologous T-lymphocytes that have been transduced with a lentiviral vector to express a chimeric antigen receptor (CAR) consisting of a single chain variable fragment (scFv) of anti-CD19, coupled to the costimulatory domain of CD28, with potential immunostimulating and antineoplastic activities. Upon transfusion, the autologous anti-CD19 CAR-CD28 T-cells ET019002 target, bind to, and induce selective toxicity in CD19-expressing B-cells. The CD19 antigen is a B-cell-specific cell surface antigen expressed in all B-cell lineage malignancies."], "t": []}], "preferred_name": "Autologous Anti-CD19 CAR-CD28 T-cells ET019002", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1440323", "l": "CD49c+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:1372900007", "l": "", "d": [], "t": []}], "preferred_name": "CD49c+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C2335330", "l": "Set of cholinergic cells of accumbens nucleus [Ch2]", "d": [], "t": []}], "preferred_name": "Set of cholinergic cells of accumbens nucleus [Ch2]", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4079015", "l": "lumbar dorsal root ganglion peripherin neuron", "d": ["A small-diameter sensory neuron whose soma is located in the lumbar dorsal root ganglion and that expresses peripherin (encoded by PRPH), a type III intermediate filament protein. This neuron is unmyelinated, conducts action potentials as a C-fiber, and encompasses nociceptive and thermoceptive functional subpopulations. In human DRG, peripherin-immunoreactive neurons are predominantly of small diameter (Chang et al. 2018, PMID:28424991), distinguishing them from large-diameter myelinated A-fiber neurons that instead express neurofilament heavy chain (Haberberger et al. 2019, PMID:31293388). In mice, peripherin similarly marks unmyelinated primary afferent neurons."], "t": []}], "preferred_name": "lumbar dorsal root ganglion peripherin neuron", "taxa": []}
{"type": "biolink:Cell", "ic": 80.27409497666227, "identifiers": [{"i": "UMLS:C1706828", "l": "Apocrine Cell", "d": [], "t": []}, {"i": "NCIT:C43374", "l": "Apocrine Cell", "d": ["A glandular secreting cell in which the apical portion of the secreting cell is cast off along with the secretory products that have accumulated therein."], "t": []}], "preferred_name": "Apocrine Cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1267900", "l": "Lymphocyte positive for CD27 antigen", "d": [], "t": []}, {"i": "SNOMEDCT:117571002", "l": "", "d": [], "t": []}], "preferred_name": "Lymphocyte positive for CD27 antigen", "taxa": []}
{"type": "biolink:Cell", "ic": 92.76600187037766, "identifiers": [{"i": "CL:4301598", "l": "Astro-OLF NN_3 astrocyte (Mmus)", "d": ["A astrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Ednrb (Mmus), Hs3st3a1 (Mmus), C230072F16Rik (Mmus), Gria2 (Mmus). Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Supertype:1168 Astro-OLF NN_3."], "t": []}], "preferred_name": "Astro-OLF NN_3 astrocyte (Mmus)", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C4086008", "l": "Autologous Interferon-producing Killer Dendritic Cells", "d": [], "t": []}, {"i": "NCIT:C125667", "l": "Autologous Interferon-producing Killer Dendritic Cells", "d": ["A preparation of autologous dendritic cells (DC) with a molecular expression profile similar to both natural killer (NK) cells and DCs, with potential antineoplastic activity. Autologous interferon-producing killer dendritic cells (IKDCs) are characterized by double-negative expression of CD3 and CD19; these cells also express low levels of CD11 and are positive for B220. They are distinguished from plasmacytoid DCs (pDCs) by the absence of lymphocyte antigen 6C (Ly6C, Gr-1) expression. IKDCs produce interferon gamma (IFN-gamma) and interleukin (IL) -12, and are able to kill typical NK target cells using NK receptors while retaining DC-like antigen-presenting activity. Upon administration of the autologous IKDCs, these cells secrete high levels of IFN-gamma and, when in contact with tumor cells, mediate TNF-related apoptosis-inducing ligand (TRAIL)-dependent direct lysis of tumor cells. The resulting apoptotic tumor antigens may be presented by the IKDCs, thus activating the immune system to exert a cytotoxic T-lymphocyte (CTL) response to further eliminate tumor cells."], "t": []}], "preferred_name": "Autologous Interferon-producing Killer Dendritic Cells", "taxa": []}
{"type": "biolink:Cell", "ic": 80.27409497666227, "identifiers": [{"i": "CL:0002144", "l": "capillary endothelial cell", "d": ["An endothelial cell found in capillaries."], "t": []}], "preferred_name": "capillary endothelial cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0004219", "l": "A2 amacrine cell", "d": ["A bistratifed retinal amacrine cell with a small dendritic field, dendrite stratification in S1-S2, and a second dendrite stratification in S5. This cell type releases the neurotransmitter glycine."], "t": []}], "preferred_name": "A2 amacrine cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0009061", "l": "intestinal crypt stem cell of anorectum", "d": ["An intestinal crypt stem cell that is located in the anorectum."], "t": []}], "preferred_name": "intestinal crypt stem cell of anorectum", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1511466", "l": "CY51", "d": [], "t": []}, {"i": "NCIT:C20240", "l": "CY51", "d": ["Provider: CyThera, Inc., San Diego, CA. No information from provider. This cell line meets the criteria for the use of human embryonic stem cells by federally funded researchers."], "t": []}], "preferred_name": "CY51", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5180537", "l": "Secondary Spermatocytes | Semen | Fertility testing", "d": [], "t": []}], "preferred_name": "Secondary Spermatocytes | Semen | Fertility testing", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:1000278", "l": "smooth muscle fiber of ileum", "d": ["A smooth muscle cell that is part of the ileum."], "t": []}, {"i": "UMLS:C0734273", "l": "Smooth muscle fiber of ileum", "d": [], "t": []}], "preferred_name": "smooth muscle fiber of ileum", "taxa": []}
{"type": "biolink:Cell", "ic": 87.18682603146104, "identifiers": [{"i": "CL:0002499", "l": "spongiotrophoblast cell", "d": ["A trophoblast cell that arises in the junctional zone (basal plate) of the placenta."], "t": []}], "preferred_name": "spongiotrophoblast cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C3640224", "l": "Allogeneic Adenovirus-specific Cytotoxic T Lymphocytes", "d": [], "t": []}, {"i": "NCIT:C101796", "l": "Allogeneic Adenovirus-specific Cytotoxic T Lymphocytes", "d": ["A population of allogeneic cytotoxic T-lymphocytes (CTLs) specifically reactive to human adenovirus (Ad) with potential immunomodulating and anti-adenoviral activities. Upon immunoprophylactic adoptive cell therapy, infusion of allogeneic Ad-specific CTLs may help reconstitute Ad-specific CTL responses in patients at risk of developing Ad infections after allogeneic stem cell transplant or in Ad-infected immunocompromised hosts. These allogeneic Ad-specific CTLs are prepared by multiple rounds of stimulation with donor peripheral blood mononuclear cells and lymphoblastoid cell lines that have been transduced with Ad5f35, a recombinant adenoviral vector carrying no transgene."], "t": []}], "preferred_name": "Allogeneic Adenovirus-specific Cytotoxic T Lymphocytes", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4033177", "l": "dorsal root ganglion EDN1 neuron", "d": ["A sensory neuron that has the soma located in the dorsal root ganglion and expresses the marker endothelin-1 (EDN1). Endothelin signaling in DRG neurons has been demonstrated in rat tissue."], "t": []}], "preferred_name": "dorsal root ganglion EDN1 neuron", "taxa": []}
{"type": "biolink:Cell", "ic": 89.40238429118027, "identifiers": [{"i": "CL:0000352", "l": "epiblast cell", "d": ["A cell of the outer layer of a blastula that gives rise to the ectoderm after gastrulation."], "t": []}], "preferred_name": "epiblast cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5174096", "l": "Myelocytes | Blood | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Myelocytes | Blood | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": 92.76600187037766, "identifiers": [{"i": "CL:0001015", "l": "CD8-alpha-low Langerhans cell", "d": ["CD8-alpha-low Langerhans cell is a Langerhans cell that is CD205-high and is CD8-alpha-low."], "t": []}], "preferred_name": "CD8-alpha-low Langerhans cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5157411", "l": "CD25 cells | XXX | Cell markers", "d": [], "t": []}], "preferred_name": "CD25 cells | XXX | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4324113", "l": "CD38+ T lymphocyte", "d": [], "t": []}], "preferred_name": "CD38+ T lymphocyte", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5417957", "l": "Anti-HER2 Antibody Conjugated Natural Killer Cells ACE1702", "d": [], "t": []}], "preferred_name": "Anti-HER2 Antibody Conjugated Natural Killer Cells ACE1702", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0427566", "l": "Macrothrombocyte", "d": [], "t": []}, {"i": "SNOMEDCT:134203001", "l": "", "d": [], "t": []}], "preferred_name": "Macrothrombocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0009058", "l": "enterocyte of anorectum", "d": ["An enterocyte that is located in the anorectum."], "t": []}], "preferred_name": "enterocyte of anorectum", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0949431", "l": "TC1 Cells", "d": [], "t": []}], "preferred_name": "TC1 Cells", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1267907", "l": "Lymphocyte positive for CD33 antigen", "d": [], "t": []}, {"i": "SNOMEDCT:117578008", "l": "", "d": [], "t": []}], "preferred_name": "Lymphocyte positive for CD33 antigen", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "UMLS:C1883048", "l": "Small Melanoma Cell", "d": [], "t": []}, {"i": "NCIT:C62401", "l": "Small Melanoma Cell", "d": [], "t": []}], "preferred_name": "Small Melanoma Cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5157231", "l": "CD1 cells | Blood | Cell markers", "d": [], "t": []}], "preferred_name": "CD1 cells | Blood | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5556348", "l": "Autologous Anti-ILT3 CAR-T Cells", "d": [], "t": []}, {"i": "NCIT:C180410", "l": "Autologous Anti-ILT3 CAR-T Cells", "d": ["A preparation of autologous T-lymphocytes that have been genetically modified to express a chimeric antigen receptor (CAR) specific for the immune inhibitory receptor leukocyte immunoglobulin-like receptor B member 4 (LILRB4; ILT3; ILT-3), with potential immune checkpoint inhibitory and antineoplastic activities. Upon administration, autologous anti-ILT3 CAR-T cells target and bind to ILT3-expressing tumor cells. This results in a cytotoxic T-lymphocyte (CTL) response against ILT3-expressing tumor cells. ILT3, a tumor associated antigen (TAA) and an immune inhibitory receptor expressed on immune suppressive myeloid cells, is highly expressed on certain hematologic cancer cells, such as monocytic acute myeloid leukemia (AML) cells. It functions as an immune checkpoint that negatively regulates T-cell activation as its extracellular domain inhibits T-cell activity. It plays an important role in tumor infiltration, T-cell suppression and immune tolerance."], "t": []}], "preferred_name": "Autologous Anti-ILT3 CAR-T Cells", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C2736930", "l": "CD19+CD34+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:1372981009", "l": "", "d": [], "t": []}], "preferred_name": "CD19+CD34+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C4733654", "l": "Autologous Mesothelin-specific Human mRNA CAR-transfected PBMCs MCY-M11", "d": [], "t": []}, {"i": "NCIT:C155775", "l": "Autologous Mesothelin-specific Human mRNA CAR-transfected PBMCs MCY-M11", "d": ["Autologous peripheral blood mononuclear cells (PBMCs) transfected with anti-mesothelin chimeric antigen receptor (CAR) mRNA, with potential antineoplastic activity. Upon intraperitoneal (IP) administration, the autologous mesothelin-specific human mRNA CAR-transfected PBMCs MCY-M11 recognize, bind to, phagocytose and directly kill cancer cells expressing mesothelin. In addition, MCY-M11 stimulates the immune system to induce a cytotoxic T-lymphocyte response against the mesothelin-expressing cancer cells. Mesothelin, a cell surface glycoprotein involved in cell adhesion, is overexpressed in many epithelial-derived cancers."], "t": []}], "preferred_name": "Autologous Mesothelin-specific Human mRNA CAR-transfected PBMCs MCY-M11", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C4724856", "l": "Autologous CD19CAR-CD28-CD137/CD27/CD3zeta-iCasp9-expressing T-lymphocytes", "d": [], "t": []}, {"i": "NCIT:C148156", "l": "Autologous CD19CAR-CD28-CD137/CD27/CD3zeta-iCasp9-expressing T-lymphocytes", "d": ["Autologous T-lymphocytes that have been transduced with a fourth generation-lentiviral vector to express the 4SCAR19 gene composed of a chimeric antigen receptor (CAR) consisting of a single chain variable fragment (scFv) of anti-CD19 coupled to the co-stimulatory molecules CD28, 4-1BB (CD137), and CD27, and to the cytoplasmic portion of the zeta chain of the human T-cell receptor (CD3zeta), and containing the apoptosis-inducible suicide gene human caspase 9 (iCASP9 or iC9), that is linked to a drug binding domain, with potential immunostimulating and antineoplastic activities. The iCASP9 construct consists of the entire coding sequence for the human FK506-drug binding protein (FKBP12) with an F36V mutation (FKBP12-F36V) that is linked to the gene encoding iC9, which is a modified form of the CASP9 gene where the sequences encoding the endogenous caspase activation and recruitment domains have been deleted. Upon transfusion, anti-CD19-CAR-CD28/CD137/CD27/CD3zeta-iCasp9-expressing autologous T-lymphocytes target and bind to CD19-expressing neoplastic B-cells. This results in a cytotoxic T-lymphocyte (CTL) response against CD19-expressing tumor cells, and causes tumor cell lysis. If the administered T-cells cause unacceptable side effects, the chemical homodimerizer AP1903, which binds to the FKBP12-F36V drug-binding domain, can be administered; this induces caspase 9 expression, and results in apoptosis of the administered 4SCAR19 T-cells. CD19, cluster of differentiation 19, is a B-cell-specific cell surface antigen overexpressed in B-cell lineage tumors. Incorporation of the costimulatory signaling domains increases human T-cell function, expansion, and survival."], "t": []}], "preferred_name": "Autologous CD19CAR-CD28-CD137/CD27/CD3zeta-iCasp9-expressing T-lymphocytes", "taxa": []}
{"type": "biolink:Cell", "ic": 89.40238429118027, "identifiers": [{"i": "CL:0000979", "l": "IgG memory B cell", "d": ["An IgG memory B cell is a class switched memory B cell that is class switched and expresses IgG on the cell surface."], "t": []}], "preferred_name": "IgG memory B cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:1000352", "l": "basal cell of epithelium of lobular bronchiole", "d": ["A basal cell that is part of the epithelium of bronchiole."], "t": []}, {"i": "UMLS:C2339119", "l": "Basal cell of epithelium of lobular bronchiole", "d": [], "t": []}], "preferred_name": "basal cell of epithelium of lobular bronchiole", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1513376", "l": "Moderately Differentiated Adenocarcinoma Cell", "d": [], "t": []}, {"i": "NCIT:C36797", "l": "Moderately Differentiated Adenocarcinoma Cell", "d": [], "t": []}], "preferred_name": "Moderately Differentiated Adenocarcinoma Cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4696692", "l": "CD19+CD27+IgD-IgM- cell", "d": [], "t": []}, {"i": "SNOMEDCT:1373236005", "l": "", "d": [], "t": []}], "preferred_name": "CD19+CD27+IgD-IgM- cell", "taxa": []}
{"type": "biolink:Cell", "ic": 80.61184433509295, "identifiers": [{"i": "CL:0001059", "l": "common myeloid progenitor, CD34-positive", "d": ["A progenitor cell committed to myeloid lineage, including the megakaryocyte and erythroid lineages. These cells are CD34-positive, and express Gata1, Gata2, C/EBPa, and Pu.1."], "t": []}], "preferred_name": "common myeloid progenitor, CD34-positive", "taxa": []}
{"type": "biolink:Cell", "ic": 90.871710685482, "identifiers": [{"i": "CL:0002485", "l": "retinal melanocyte", "d": ["A melanocyte of the retina. This cell type is distinct from pigmented retinal epithelium."], "t": []}], "preferred_name": "retinal melanocyte", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4697033", "l": "IgM+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:1373081003", "l": "", "d": [], "t": []}], "preferred_name": "IgM+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5168980", "l": "Immature granulocytes | Blood | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Immature granulocytes | Blood | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5216249", "l": "Lymphocytes|NCnc|Pt|Bld", "d": [], "t": []}], "preferred_name": "Lymphocytes|NCnc|Pt|Bld", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5206130", "l": "Autologous PRAME-targeting TCR-engineered T-cells IMA203", "d": [], "t": []}, {"i": "NCIT:C161831", "l": "Autologous PRAME-targeting TCR-engineered T-cells IMA203", "d": [], "t": []}], "preferred_name": "Autologous PRAME-targeting TCR-engineered T-cells IMA203", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1267821", "l": "T lymphocyte positive for both CD3 antigen and CD4 antigen", "d": [], "t": []}, {"i": "SNOMEDCT:115396002", "l": "", "d": [], "t": []}], "preferred_name": "T lymphocyte positive for both CD3 antigen and CD4 antigen", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4684961", "l": "Tabelecleucel", "d": [], "t": []}], "preferred_name": "Tabelecleucel", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4518169", "l": "Population of all band eosinophils in portion of fluid", "d": [], "t": []}, {"i": "SNOMEDCT:725233000", "l": "", "d": [], "t": []}], "preferred_name": "Population of all band eosinophils in portion of fluid", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C2697994", "l": "Allogeneic Multipotent Adult Progenitor Cells", "d": [], "t": []}], "preferred_name": "Allogeneic Multipotent Adult Progenitor Cells", "taxa": []}
{"type": "biolink:Cell", "ic": 87.18682603146104, "identifiers": [{"i": "UMLS:C1512141", "l": "ES ES Cell Line", "d": [], "t": []}, {"i": "NCIT:C20248", "l": "ES ES Cell Line", "d": [], "t": []}], "preferred_name": "ES ES Cell Line", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "UMLS:C1708885", "l": "Malignant Lactotroph Cell", "d": [], "t": []}, {"i": "NCIT:C45951", "l": "Malignant Lactotroph Cell", "d": [], "t": []}], "preferred_name": "Malignant Lactotroph Cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5157428", "l": "CD3+CD16+CD56+ cells | Blood | Cell markers", "d": [], "t": []}], "preferred_name": "CD3+CD16+CD56+ cells | Blood | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1881029", "l": "HSV-TK-Transduced Donor Lymphocytes", "d": [], "t": []}, {"i": "NCIT:C67047", "l": "HSV-TK-Transduced Donor Lymphocytes", "d": ["A preparation of donor lymphocytes transduced with the suicide gene herpes simplex virus thymidine kinase (HSV-TK) with potential immunomodulating activity. Administration of HSV-TK-transduced lymphocytes after T cell-depleted allogeneic stem cell transplantation allows an early controllable immune reconstitution, which takes advantage of the antitumor effect of donor lymphocytes and helps to mitigate the risk of post-transplant opportunistic infection. To control graft-versus-host disease (GvHD) due to donor lymphocyte infusion, HSV-TK-transduced donor lymphocytes are selectively eliminated by administration of the antiviral agent ganciclovir. Ganciclovir, a prodrug, is readily phosphorylated by the suicide gene HSV-TK within HSV-TK-transduced lymphocytes to its monophosphate form and, subsequently, converted into its active triphosphate form, which specifically kills HSV-TK- transduced donor lymphocytes."], "t": []}], "preferred_name": "HSV-TK-Transduced Donor Lymphocytes", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5216210", "l": "Erythrocytes|NCnc|Pt|Bld", "d": [], "t": []}], "preferred_name": "Erythrocytes|NCnc|Pt|Bld", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C3900001", "l": "Autologous Cytomegalovirus-specific Cytotoxic T-lymphocytes", "d": [], "t": []}, {"i": "NCIT:C116732", "l": "Autologous Cytomegalovirus-specific Cytotoxic T-lymphocytes", "d": ["A population of autologous cytotoxic-T lymphocytes (CTLs) specifically reactive to the herpes virus cytomegalovirus (CMV) with potential immunomodulating and antiviral activities. Upon administration with the autologous CMV-specific CTLs, these CTLs lyse CMV-infected cells, thereby preventing or decreasing the occurrence of CMV viral disease, or reducing the amount of antiviral drug therapy needed to eradicate CMV."], "t": []}], "preferred_name": "Autologous Cytomegalovirus-specific Cytotoxic T-lymphocytes", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1267973", "l": "Lymphocyte positive for CD82 antigen", "d": [], "t": []}, {"i": "SNOMEDCT:117413009", "l": "", "d": [], "t": []}], "preferred_name": "Lymphocyte positive for CD82 antigen", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5761771", "l": "Carlecortemcel-L", "d": [], "t": []}], "preferred_name": "Carlecortemcel-L", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0011016", "l": "flagellated sperm cell", "d": ["A motile sperm cell that contains a slender threadlike microscopic appendage that enables motion."], "t": []}], "preferred_name": "flagellated sperm cell", "taxa": []}
{"type": "biolink:Cell", "ic": 90.871710685482, "identifiers": [{"i": "CL:0002345", "l": "CD27-low, CD11b-low immature natural killer cell, mouse", "d": ["An immature natural killer cell that is NK1.1-positive, DX5-positive, Ly49-positive, CD27-low and CD11b-low. This cell type is found in high numbers in the liver."], "t": []}], "preferred_name": "CD27-low, CD11b-low immature natural killer cell, mouse", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5447425", "l": "Autologous Differentiated Anti-BCMA CAR T-cells ARI0002h", "d": [], "t": []}], "preferred_name": "Autologous Differentiated Anti-BCMA CAR T-cells ARI0002h", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C4725001", "l": "MDS Neoantigen-specific Autologous T-lymphocytes", "d": [], "t": []}, {"i": "NCIT:C148393", "l": "MDS Neoantigen-specific Autologous T-lymphocytes", "d": ["A preparation of autologous T-lymphocytes that are exposed, ex vivo, to multiple, patient-specific myelodysplastic syndrome (MDS) stem cell neoantigens, with potential immunostimulating and antineoplastic activities. Upon infusion of the MDS neoantigen-specific autologous T-lymphocytes, the immunized T-cells specifically target and lyse cells expressing the MDS neoantigens."], "t": []}], "preferred_name": "MDS Neoantigen-specific Autologous T-lymphocytes", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1440341", "l": "CD63+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:1372918005", "l": "", "d": [], "t": []}], "preferred_name": "CD63+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0011114", "l": "segmented neutrophil of bone marrow", "d": ["A segmented neutrophilic cell of the bone marrow reserve pool that expresses CD11b (integrin alpha-M) and high levels of CD16 (low affinity immunoglobulin gamma Fc region receptor III) on its cell surface."], "t": []}], "preferred_name": "segmented neutrophil of bone marrow", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C6022633", "l": "AV0113 DC-CIT", "d": [], "t": []}], "preferred_name": "AV0113 DC-CIT", "taxa": []}
{"type": "biolink:Cell", "ic": 82.62268137420203, "identifiers": [{"i": "CL:1000909", "l": "kidney loop of Henle epithelial cell", "d": ["Any nephron tubule epithelial cell that is part of some loop of Henle."], "t": []}], "preferred_name": "kidney loop of Henle epithelial cell", "taxa": []}
{"type": "biolink:Cell", "ic": 83.63771255585968, "identifiers": [{"i": "CL:0000476", "l": "thyrotroph", "d": ["A basophil cell of the anterior pituitary that produces thyroid stimulating hormone, thyrotrophin. This cell type is elongated, polygonal and lie in clusters towards the adenohypophyseal center."], "t": []}], "preferred_name": "thyrotroph", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C4084782", "l": "4H11-28z/fIL-12/EGFRt-expressing Autologous T-lymphocytes", "d": [], "t": []}, {"i": "NCIT:C123823", "l": "4H11-28z/fIL-12/EGFRt-expressing Autologous T-lymphocytes", "d": ["A preparation of genetically modified autologous T-lymphocytes transduced with a retroviral vector expressing a chimeric antigen receptor (CAR) targeting the human tumor-associated antigen (TAA) MUC16ecto and encoding the human pro-inflammatory cytokine interleukin-12 (IL-12), fused to the signaling domain of the zeta chain of the TCR/CD3 complex (28z), and a truncated form of the human epidermal growth factor receptor (EGFRt), with potential immunostimulating and antineoplastic activities. Upon intravenous administration, 4H11-28z/fIL-12/EGFRt-expressing autologous T-lymphocytes are directed to and induce selective toxicity in MUC16-expressing tumor cells. In addition, the T-cells secrete IL-12 which induces secretion of interferon-gamma, promotes the activation of natural killer cells (NKs), and induces cytotoxic T-cell responses against tumor cells, which may result in immune-mediated tumor cell death and inhibition of tumor cell proliferation. Devoid of both ligand binding domains and tyrosine kinase activity, the expressed EGFRt both facilitates in vivo detection of the administered, transduced T-cells and can promote elimination of those cells through a cetuximab-induced antibody-dependent cellular cytotoxicity (ADCC) response. MUC16, a transmembrane protein and glycosylated mucin, is overexpressed on the cell surface of the majority of ovarian cancer cells but not on healthy cells. MUC16ecto is the extracellular portion of MUC-16 and is the part that is retained by cells after cleavage of CA-125."], "t": []}], "preferred_name": "4H11-28z/fIL-12/EGFRt-expressing Autologous T-lymphocytes", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0002537", "l": "amnion mesenchymal stem cell", "d": ["A mesenchymal stem cell of the amnion membrane."], "t": []}], "preferred_name": "amnion mesenchymal stem cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1267929", "l": "Lymphocyte positive for both CD45 antigen and CD14 antigen", "d": [], "t": []}, {"i": "SNOMEDCT:117372008", "l": "", "d": [], "t": []}], "preferred_name": "Lymphocyte positive for both CD45 antigen and CD14 antigen", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1440147", "l": "Blasts.CD34", "d": [], "t": []}], "preferred_name": "Blasts.CD34", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5216205", "l": "Eosinophils|NCnc|Pt|Synv fld", "d": [], "t": []}], "preferred_name": "Eosinophils|NCnc|Pt|Synv fld", "taxa": []}
{"type": "biolink:Cell", "ic": 73.04009684703995, "identifiers": [{"i": "CL:0005014", "l": "auditory epithelial supporting cell", "d": ["A non-sensory cell that extends from the basement membrane to the apical surface of the auditory epithelium and provides support for auditory hair cells."], "t": []}], "preferred_name": "auditory epithelial supporting cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5216298", "l": "Nucleated cells|NCnc|Pt|Bone mar", "d": [], "t": []}], "preferred_name": "Nucleated cells|NCnc|Pt|Bone mar", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "MESH:D013172", "l": "Spores, Fungal", "d": [], "t": []}], "preferred_name": "Spores, Fungal", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4527227", "l": "Allogeneic CD19-specific Universal CAR19-expressing T-lymphocytes", "d": [], "t": []}], "preferred_name": "Allogeneic CD19-specific Universal CAR19-expressing T-lymphocytes", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "UMLS:C0333721", "l": "Fusiform cell", "d": [], "t": []}, {"i": "NCIT:C32645", "l": "Fusiform Cell", "d": ["A cell with spindle-like morphologic characteristics.."], "t": []}, {"i": "SNOMEDCT:15409002", "l": "", "d": [], "t": []}], "preferred_name": "Fusiform cell", "taxa": []}
{"type": "biolink:Cell", "ic": 65.80609871741763, "identifiers": [{"i": "CL:0002563", "l": "intestinal epithelial cell", "d": ["An epithelial cell of the lining of the intestine."], "t": []}], "preferred_name": "intestinal epithelial cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5216219", "l": "Erythrocytes|NCnc|Pt|Synv fld", "d": [], "t": []}], "preferred_name": "Erythrocytes|NCnc|Pt|Synv fld", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4307026", "l": "Bergmann glial cell (Mmus)", "d": ["A Bergmann glial cell of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Gpr37l1 (Mmus), Ctxn3 (Mmus). It is distinguished from other Astro-Epen cells by expression of Gpr37l1, Ctxn3. These cells are located in the Cerebellum, brain . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5206 Bergmann NN_1."], "t": []}], "preferred_name": "Bergmann glial cell (Mmus)", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5175148", "l": "Nucleated cells | Bronchial | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Nucleated cells | Bronchial | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": 73.15076615569336, "identifiers": [{"i": "CL:4023026", "l": "direct pathway medium spiny neuron", "d": ["A medium spiny neuron that expresses dopamine type 1 receptors and projects to the globus pallidus internus or the substantia nigra pars reticulata.", "A GABAergic medium spiny neuron located in the striatum that gives rise to the direct basal ganglia pathway. It projects directly to the GPi and SNr, where it inhibits tonically active GABAergic output neurons to disinhibit thalamic and brainstem motor targets (Gerfen. 2023). In mice and humans, this cell selectively expresses the D1 dopamine receptor (DRD1), which couples to stimulatory G-proteins (Gs/Gαolf) to increase cAMP and activate PKA-dependent signaling cascades (Gerfen et al., 1990; Kebabian & Calne, 1979). Functionally, activation of this cell promotes selected motor actions by disinhibiting thalamic and midbrain motor centers (Mink, 1996; Cui et al., 2013)."], "t": []}], "preferred_name": "direct pathway medium spiny neuron", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5417937", "l": "Allogeneic EBV/CMV/AdV/HHV6/BKV/JCV-specific CTLs ALVR105", "d": [], "t": []}], "preferred_name": "Allogeneic EBV/CMV/AdV/HHV6/BKV/JCV-specific CTLs ALVR105", "taxa": []}
{"type": "biolink:Cell", "ic": 83.11065783093733, "identifiers": [{"i": "UMLS:C1881543", "l": "Malignant Eccrine Cell", "d": [], "t": []}, {"i": "NCIT:C62499", "l": "Malignant Eccrine Cell", "d": [], "t": []}], "preferred_name": "Malignant Eccrine Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 75.08236434612573, "identifiers": [{"i": "CL:0000008", "l": "migratory cranial neural crest cell", "d": ["Cell that is part of the migratory cranial neural crest population. Migratory cranial neural crest cells develop from premigratory cranial neural crest cells and have undergone epithelial to mesenchymal transition and delamination."], "t": []}], "preferred_name": "migratory cranial neural crest cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4033022", "l": "mucus secreting cell of bronchus submucosal gland", "d": ["A mucus secreting cell of a submucosal gland of the bronchus."], "t": []}], "preferred_name": "mucus secreting cell of bronchus submucosal gland", "taxa": []}
{"type": "biolink:Cell", "ic": 92.76600187037766, "identifiers": [{"i": "UMLS:C1513066", "l": "Neoplastic Medium-Sized B-Lymphocyte with Eccentric Basophilic Cytoplasm", "d": [], "t": []}, {"i": "NCIT:C37006", "l": "Neoplastic Medium-Sized B-Lymphocyte with Eccentric Basophilic Cytoplasm", "d": [], "t": []}], "preferred_name": "Neoplastic Medium-Sized B-Lymphocyte with Eccentric Basophilic Cytoplasm", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5814739", "l": "omidubicel-onlv", "d": [], "t": []}], "preferred_name": "omidubicel-onlv", "taxa": []}
{"type": "biolink:Cell", "ic": 85.53200374075534, "identifiers": [{"i": "CL:0004117", "l": "alpha retinal ganglion cell (Mmus)", "d": ["A large-bodied retinal projection neuron with wide monostratified dendritic arbors in defined IPL strata, high neurofilament and osteopontin expression, and a thick, fast-conducting axon. It shows short-latency, non-direction-selective responses with large receptive fields and a distinctive rapid action potential waveform. In mammals it forms about five percent of RGCs and includes four conserved ON and OFF sustained and transient subtypes."], "t": []}], "preferred_name": "alpha retinal ganglion cell (Mmus)", "taxa": []}
{"type": "biolink:Cell", "ic": 77.60424150429895, "identifiers": [{"i": "CL:0002187", "l": "basal cell of epidermis", "d": ["A mitotically active, columnar-shaped keratinocyte located in the stratum basale of the epidermis and attached to the basement membrane. This cell exhibits heterogeneity, encompassing stem and progenitor subpopulations with distinct molecular and proliferative characteristics (Haensel et al., 2020), and serves as the primary source of new keratinocytes for epidermal renewal, homeostasis, and regeneration."], "t": []}, {"i": "UMLS:C1182624", "l": "Basal cell of epidermis", "d": [], "t": []}], "preferred_name": "basal cell of epidermis", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1709903", "l": "Renal Tumor-Reactive Autologous Peripheral Blood Lymphocyte", "d": [], "t": []}, {"i": "NCIT:C48816", "l": "Renal Tumor-Reactive Autologous Peripheral Blood Lymphocyte", "d": ["Peripheral blood lymphocytes (PBL) harvested from the blood of a renal cancer patient and exposed in vitro to renal tumor-associated antigens (TAA).  Introducing these renal tumor-reactive autologous peripheral blood lymphocytes back to the same patient target tumor cells expressing these TAAs and could induce a cytotoxic T-cell-mediated immune response against renal cell cancer."], "t": []}], "preferred_name": "Renal Tumor-Reactive Autologous Peripheral Blood Lymphocyte", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5157317", "l": "CD15 blasts | Blood | Cell markers", "d": [], "t": []}], "preferred_name": "CD15 blasts | Blood | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": 90.871710685482, "identifiers": [{"i": "CL:4301575", "l": "Lugaro cell (Mmus)", "d": ["A Lugaro cell of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Pthlh (Mmus), Tfap2b (Mmus), Rspo2 (Mmus). Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Supertype:1145 CB PLI Gly-Gaba_2.", "A Purkinje layer interneuron of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Pthlh (Mmus), Tfap2b (Mmus), Rspo2 (Mmus). Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Supertype:1145 CB PLI Gly-Gaba_2."], "t": []}], "preferred_name": "Lugaro cell (Mmus)", "taxa": []}
{"type": "biolink:Cell", "ic": 65.95407503160773, "identifiers": [{"i": "CL:0000850", "l": "serotonergic neuron", "d": ["A neuron that releases serotonin as a neurotransmitter."], "t": []}, {"i": "UMLS:C3178783", "l": "Serotonergic Neurons", "d": [], "t": []}, {"i": "MESH:D059326", "l": "Serotonergic Neurons", "d": [], "t": []}], "preferred_name": "serotonergic neuron", "taxa": []}
{"type": "biolink:Cell", "ic": 66.79071567011577, "identifiers": [{"i": "UMLS:C5854856", "l": "Anti-CD19 CAR-T cells", "d": [], "t": []}, {"i": "NCIT:C176018", "l": "Anti-CD19 CAR T Cells Preparation", "d": ["Any preparation of CAR-T cells that targets CD19."], "t": []}], "preferred_name": "Anti-CD19 CAR-T cells", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0882871", "l": "CD41+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:1372883008", "l": "", "d": [], "t": []}], "preferred_name": "CD41+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5666940", "l": "CT103A", "d": [], "t": []}], "preferred_name": "CT103A", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5554965", "l": "Autologous Anti-HER2 CAR T-cells CCT303-406", "d": [], "t": []}, {"i": "NCIT:C178340", "l": "Autologous Anti-HER2 CAR T-cells CCT303-406", "d": ["A preparation of autologous T-lymphocytes that have been genetically modified to express a chimeric antigen receptor (CAR) targeting the tumor-associated antigen (TAA) human epidermal growth factor receptor 2 (HER2; ErbB2; HER-2), with potential immunostimulating and antineoplastic activities. Upon administration, autologous anti-HER2 CAR T-cells CCT303-406 target and bind to HER2-expressing tumor cells, thereby inducing selective toxicity in HER2-expressing tumor cells. HER2 is overexpressed in a variety of cancer cell types and is associated with increased tumor cell proliferation."], "t": []}], "preferred_name": "Autologous Anti-HER2 CAR T-cells CCT303-406", "taxa": []}
{"type": "biolink:Cell", "ic": 84.83823963392128, "identifiers": [{"i": "CL:0000446", "l": "chief cell of parathyroid gland", "d": ["An epithelial cell of the parathyroid gland that is arranged in wide, irregular interconnecting columns; responsible for the synthesis and secretion of parathyroid hormone."], "t": []}, {"i": "UMLS:C0229586", "l": "Structure of parathyroid chief cell", "d": [], "t": []}, {"i": "NCIT:C33266", "l": "Parathyroid Gland Chief Cell", "d": ["The primary cell of the parathyroid gland. Its contains secretory granules, large Golgi complexes, and moderate numbers of mitochondria. It produces parathyroid hormone. The cells occur in sheets interspersed with areas of fatty tissue. Occasionally the cells are arranged in follicles."], "t": []}, {"i": "SNOMEDCT:49796000", "l": "", "d": [], "t": []}], "preferred_name": "chief cell of parathyroid gland", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0002642", "l": "epithelial cell of esophageal cardiac gland", "d": ["An epithelial cell of the esophageal cardiac gland that occurs both in the proximal and distal esophagus, within the lamina propia."], "t": []}, {"i": "UMLS:C2339178", "l": "Epithelial cell of esophageal cardiac gland", "d": [], "t": []}], "preferred_name": "epithelial cell of esophageal cardiac gland", "taxa": []}
{"type": "biolink:Cell", "ic": 73.98236851641934, "identifiers": [{"i": "CL:0000547", "l": "proerythroblast", "d": ["An immature, nucleated erythrocyte occupying the stage of erythropoeisis that follows formation of erythroid progenitor cells. This cell is CD71-positive, has both a nucleus and a nucleolus, and lacks hematopoeitic lineage markers."], "t": []}], "preferred_name": "proerythroblast", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5216312", "l": "Granulocytes|NCnc|Pt|Plr fld", "d": [], "t": []}], "preferred_name": "Granulocytes|NCnc|Pt|Plr fld", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0001020", "l": "mature CD8-alpha-low Langerhans cell", "d": ["Mature CD8-alpha-low Langerhans cell is a CD8-alpha-low Langerhans cell that that is CD80-high, CD86-high, MHCII-high and is CD83-positive."], "t": []}], "preferred_name": "mature CD8-alpha-low Langerhans cell", "taxa": []}
{"type": "biolink:Cell", "ic": 78.54651317367835, "identifiers": [{"i": "UMLS:C1522639", "l": "Mouse Leukocyte", "d": [], "t": []}, {"i": "NCIT:C22570", "l": "Mouse Leukocyte", "d": [], "t": []}], "preferred_name": "Mouse Leukocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 57.26073484449116, "identifiers": [{"i": "UMLS:C1518172", "l": "Malignant Endocrine Cell", "d": [], "t": []}, {"i": "NCIT:C36929", "l": "Malignant Endocrine Cell", "d": [], "t": []}], "preferred_name": "Malignant Endocrine Cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0598102", "l": "polarized cell", "d": [], "t": []}], "preferred_name": "polarized cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5155166", "l": "Blasts | Blood cord | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Blasts | Blood cord | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5177457", "l": "Plasma cells immature | Blood | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Plasma cells immature | Blood | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1254549", "l": "Stippled Erythrocyte", "d": [], "t": []}], "preferred_name": "Stippled Erythrocyte", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C2329053", "l": "Goblet cell of epithelium proper of jejunum", "d": [], "t": []}], "preferred_name": "Goblet cell of epithelium proper of jejunum", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4033019", "l": "ON-blue cone bipolar cell", "d": ["An ON bipolar cell type with dendrites selectively contacting S-cones."], "t": []}], "preferred_name": "ON-blue cone bipolar cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C3640939", "l": "tisagenlecleucel", "d": [], "t": []}, {"i": "MESH:C000626284", "l": "tisagenlecleucel", "d": [], "t": []}, {"i": "SNOMEDCT:764085003", "l": "", "d": [], "t": []}, {"i": "SNOMEDCT:764086002", "l": "", "d": [], "t": []}], "preferred_name": "tisagenlecleucel", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4240451", "l": "Smooth muscle fiber of intestine", "d": [], "t": []}], "preferred_name": "Smooth muscle fiber of intestine", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4040004", "l": "mesenchymal stem cell of orbital adipose tissue", "d": ["Any mesenchymal stem cell of adipose tissue that is part of an orbital region."], "t": []}], "preferred_name": "mesenchymal stem cell of orbital adipose tissue", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5168997", "l": "Immunodeficiency markers | XXX | Cell markers", "d": [], "t": []}], "preferred_name": "Immunodeficiency markers | XXX | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": 70.98321298487613, "identifiers": [{"i": "CL:4030029", "l": "blood lymphocyte", "d": ["A lymphocyte located in blood."], "t": []}], "preferred_name": "blood lymphocyte", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5216217", "l": "Erythrocytes|NCnc|Pt|Periton fld", "d": [], "t": []}], "preferred_name": "Erythrocytes|NCnc|Pt|Periton fld", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:1000281", "l": "smooth muscle cell of cecum", "d": ["A smooth muscle cell that is part of the cecum."], "t": []}, {"i": "UMLS:C0734798", "l": "Smooth muscle fiber of cecum", "d": [], "t": []}], "preferred_name": "smooth muscle cell of cecum", "taxa": []}
{"type": "biolink:Cell", "ic": 75.54735764213513, "identifiers": [{"i": "UMLS:C1711301", "l": "Malignant Oval Endothelial Cell", "d": [], "t": []}, {"i": "NCIT:C53413", "l": "Malignant Oval Endothelial Cell", "d": [], "t": []}], "preferred_name": "Malignant Oval Endothelial Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 72.9312568671559, "identifiers": [{"i": "CL:4030064", "l": "L5 intratelencephalic projecting glutamatergic neuron", "d": ["An intratelencephalic-projecting glutamatergic neuron with a soma found in cortical layer 5.", "An intratelencephalic-projecting glutamatergic neuron with a soma found in cortical layer 5. The standard transcriptomic reference data for this cell type can be found on the CellxGene census under the collection: 'Transcriptomic cytoarchitecture reveals principles of human neocortex organization', dataset: 'Supercluster: IT-projecting excitatory neurons', Author Categories: 'CrossArea_subclass', L5 IT."], "t": []}], "preferred_name": "L5 intratelencephalic projecting glutamatergic neuron", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0009032", "l": "B cell of appendix", "d": ["A B cell that is located in a vermiform appendix."], "t": []}], "preferred_name": "B cell of appendix", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "UMLS:C1708865", "l": "Malignant Chondrocyte with Clear Cytoplasm", "d": [], "t": []}, {"i": "NCIT:C53492", "l": "Malignant Chondrocyte with Clear Cytoplasm", "d": [], "t": []}], "preferred_name": "Malignant Chondrocyte with Clear Cytoplasm", "taxa": []}
{"type": "biolink:Cell", "ic": 78.80476858236055, "identifiers": [{"i": "UMLS:C1711389", "l": "Neoplastic Erythroblast", "d": [], "t": []}, {"i": "NCIT:C43217", "l": "Neoplastic Erythroblast", "d": [], "t": []}], "preferred_name": "Neoplastic Erythroblast", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5157609", "l": "CD55 and CD59 RBC | Blood | Cell markers", "d": [], "t": []}], "preferred_name": "CD55 and CD59 RBC | Blood | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4030022", "l": "renal medullary fibroblast", "d": ["A fibroblast that is located in the renal medulla interstitium."], "t": []}], "preferred_name": "renal medullary fibroblast", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0229588", "l": "Entire parathyroid wasserhelle cell", "d": [], "t": []}, {"i": "SNOMEDCT:88360009", "l": "", "d": [], "t": []}], "preferred_name": "Entire parathyroid wasserhelle cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0011021", "l": "fibroblast of upper back skin", "d": ["A fibroblast that is part of upper back skin."], "t": []}], "preferred_name": "fibroblast of upper back skin", "taxa": []}
{"type": "biolink:Cell", "ic": 74.64805296934512, "identifiers": [{"i": "UMLS:C1519377", "l": "Neoplastic Small Lymphocyte with Clumped Chromatin", "d": [], "t": []}, {"i": "NCIT:C36999", "l": "Neoplastic Small Lymphocyte with Clumped Chromatin", "d": [], "t": []}], "preferred_name": "Neoplastic Small Lymphocyte with Clumped Chromatin", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4052026", "l": "type IIx muscle cell", "d": ["A fast type II muscle cell that is part of the skeletal muscle tissue. This cell is characterized by its intermediate metabolic profile, utilizing both glycolytic and oxidative pathways for energy production. In humans, it is distinguished by the expression of myosin heavy chain 1 (MYH1)."], "t": []}], "preferred_name": "type IIx muscle cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5157550", "l": "CD4+CD45RO+ cells | Blood | Cell markers", "d": [], "t": []}], "preferred_name": "CD4+CD45RO+ cells | Blood | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0432610", "l": "Giant metamyelocyte", "d": [], "t": []}, {"i": "SNOMEDCT:259711002", "l": "", "d": [], "t": []}], "preferred_name": "Giant metamyelocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0009112", "l": "centroblast", "d": ["A germinal center B cell found in a lymph node germinal center dark zone."], "t": []}], "preferred_name": "centroblast", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5157424", "l": "CD3 cells | Blood | Cell markers", "d": [], "t": []}], "preferred_name": "CD3 cells | Blood | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5854524", "l": "Autologous PD1-knockout CD19-specific CAR T-cells BRL-201", "d": [], "t": []}, {"i": "NCIT:C200327", "l": "Autologous PD1-knockout CD19-specific CAR T-cells BRL-201", "d": ["A preparation of autologous T-lymphocytes that are non-virally gene-edited with the clustered regularly interspaced short palindromic repeats (CRISPR)-Cas9 nuclease complex to integrate a chimeric antigen receptor (CAR) targeting the tumor-associated antigen (TAA) CD19 in the locus of the programmed cell death 1 (PD-1; PDCD1; CD279; programmed death-1) gene, with potential immunomodulating and antineoplastic activities. Upon administration, autologous PD1-knockout CD19-specific CAR T-cells BRL-201 specifically target and bind to CD19-expressing tumor cells, thereby selectively lysing CD19-expressing tumor cells. CD19 antigen is a B-cell specific cell surface antigen overexpressed in B-cell lineage malignancies. Expression of PD-1, an inhibitory receptor expressed on activated T-cells, plays a key role in cytotoxic T-lymphocyte (CTL) suppression, T-cell exhaustion and CTL apoptosis. PD-1 knockout may abrogate T-cell exhaustion and increase T-cell activity and cytotoxicity."], "t": []}], "preferred_name": "Autologous PD1-knockout CD19-specific CAR T-cells BRL-201", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5707014", "l": "STING-dependent Activators-loaded Autologous Leukemic Cells", "d": [], "t": []}, {"i": "NCIT:C187299", "l": "STING-dependent Activators-loaded Autologous Leukemic Cells", "d": ["A preparation of autologous ultraviolet (UV)-irradiated leukemic cells loaded with STING-dependent activators (STAVs), with potential immunomodulating and antineoplastic activities. Upon intravenous administration of STAVs-loaded autologous leukemic cells, the STAVs activates STING-mediated signaling pathways. This activates the immune response through the activation of certain immune cells, including dendritic cells (DCs), which induces the expression of cytokines and chemokines, and leads to an antigen-specific T-cell mediated immune response against the patient's own leukemic cells. STING, a transmembrane protein that activates immune cells in the tumor microenvironment (TME), plays a key role in the activation of the innate immune system. By using the patient's own irradiated cancer cells as antigens, the patient's immune system is exposed to the entire repertoire of this individual's tumor-associated antigens (TAAs)."], "t": []}], "preferred_name": "STING-dependent Activators-loaded Autologous Leukemic Cells", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "CL:0000582", "l": "neutrophilic metamyelocyte", "d": ["A neutrophil precursor in the granulocytic series, being a cell intermediate in development between a myelocyte and the band form neutrophil. The protein synthesis seen in earlier stages decreases or stops; the nucleus becomes indented where the indentation is smaller than half the distance to the farthest nuclear margin; chromatin becomes coarse and clumped; specific granules predominate while primary granules are rare; and the cytoplasm becomes amphophilic like that of a mature granulocyte. This cell type is integrin alpha-M-positive, CD13-negative, CD15-positive, CD16-positive, CD33-positive, CD24-positive, fMLP receptor-negative and has expression of C/EBP-a, C/EBP-e, PU.1 transcription factor, lactotransferrin, myeloperoxidase and neutrophil gelatinase associated lipocalin."], "t": []}], "preferred_name": "neutrophilic metamyelocyte", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0282542", "l": "Cells, Immobilized", "d": [], "t": []}, {"i": "MESH:D018914", "l": "Cells, Immobilized", "d": [], "t": []}], "preferred_name": "Cells, Immobilized", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5216265", "l": "Mesothelial cells|NCnc|Pt|Plr fld", "d": [], "t": []}], "preferred_name": "Mesothelial cells|NCnc|Pt|Plr fld", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1280426", "l": "Entire beta Cell of islet", "d": [], "t": []}, {"i": "SNOMEDCT:247867004", "l": "", "d": [], "t": []}], "preferred_name": "Entire beta Cell of islet", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0314584", "l": "Blast colony-forming unit", "d": [], "t": []}, {"i": "SNOMEDCT:445113006", "l": "", "d": [], "t": []}], "preferred_name": "Blast colony-forming unit", "taxa": []}
{"type": "biolink:Cell", "ic": 90.871710685482, "identifiers": [{"i": "UMLS:C1519378", "l": "Small Meningothelial Cell", "d": [], "t": []}, {"i": "NCIT:C37161", "l": "Small Meningothelial Cell", "d": [], "t": []}], "preferred_name": "Small Meningothelial Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0000659", "l": "eggshell secreting cell", "d": ["An extracellular matrix secreting cell that secretes eggshell."], "t": []}], "preferred_name": "eggshell secreting cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0000043", "l": "mature basophil", "d": ["A fully differentiated basophil, a granular leukocyte with an irregularly shaped, pale-staining nucleus that is partially constricted into two lobes, and with cytoplasm that contains coarse granules of variable size. Basophils contain vasoactive amines such as histamine and serotonin, which are released on appropriate stimulation."], "t": []}], "preferred_name": "mature basophil", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1519682", "l": "Tumor Infiltrating Lymphocytes-N2-Transduced", "d": [], "t": []}, {"i": "NCIT:C29478", "l": "Tumor Infiltrating Lymphocytes-N2-Transduced", "d": ["A preparation of lymphocytes harvested from a patient and genetically modified ex vivo for use in gene therapy for the patient's cancer.  Ex vivo, the lymphocytes are transduced with the N2 retroviral vector, which is modified to express a gene whose protein product either kills tumor cells or elicits specific anti-tumor immunity. Genetically modified lymphocytes are infused back into the patient from whom they were harvested, locate to the tumor site, and express the candidate protein that kills tumor cells or stimulates host anti-tumor immunity. (NCI04)"], "t": []}], "preferred_name": "Tumor Infiltrating Lymphocytes-N2-Transduced", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0002030", "l": "Fc-epsilon RIalpha-high basophil progenitor cell", "d": ["A lineage negative, Sca1-negative basophil progenitor cell that is Fc epsilon RIalpha-high."], "t": []}], "preferred_name": "Fc-epsilon RIalpha-high basophil progenitor cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4052051", "l": "uterine natural killer cell 1, human", "d": ["​​A uterine natural killer subset that is present in the endometrial lining during the non-pregnant state (Garcia-Alonso et al., 2021) and in the decidua during pregnancy (Vento-Tormo et al., 2018). It expresses the uterine resident marker CD49a and is distinguished from uNK2 and uNK3 by CD39 expression and the absence of CD103 (Whettlock et al., 2022) and CD160 (Marečková et al., 2024). It also expresses higher levels of killer-cell immunoglobulin-like receptors (KIRs) and leukocyte immunoglobulin-like receptor B1 (LILRB1), which facilitate interaction with human leukocyte antigens (HLAs) on extravillous trophoblast cells, promoting immune tolerance and implantation. Enriched in the endometrium post-ovulation (Marečková et al., 2024) and prominent in early pregnancy (Whettlock et al., 2022), uNK1 regulates trophoblast invasion and spiral artery remodeling (Zhang & Wei, 2021)."], "t": []}], "preferred_name": "uterine natural killer cell 1, human", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4033012", "l": "smooth muscle cell of large intestine smooth muscle longitudinal layer", "d": ["A(n) smooth muscle cell that is part of a(n) large intestine smooth muscle longitudinal layer."], "t": []}], "preferred_name": "smooth muscle cell of large intestine smooth muscle longitudinal layer", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5177776", "l": "Polyclonal plasma cells/Plasma cells.total | Bone marrow | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Polyclonal plasma cells/Plasma cells.total | Bone marrow | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0013921", "l": "Tumor Cells, Embolic", "d": [], "t": []}], "preferred_name": "Tumor Cells, Embolic", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4310133", "l": "STRd D2 Striomat hybrid medium spiny neuron (Primate)", "d": ["A indirect pathway medium spiny neuron of the Primates brain. These cells are located in the striatum . Reference transcriptomic data for this type can be found in the dataset/taxonomy - HMBA Basal Ganglia Consensus Taxonomy in cell set Group:STRd D2 StrioMat Hybrid MSN."], "t": []}], "preferred_name": "STRd D2 Striomat hybrid medium spiny neuron (Primate)", "taxa": []}
{"type": "biolink:Cell", "ic": 92.76600187037766, "identifiers": [{"i": "CL:1000236", "l": "posterior lateral line nerve glial cell", "d": ["Any glial cell that is part of some posterior lateral line nerve."], "t": []}], "preferred_name": "posterior lateral line nerve glial cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4042006", "l": "dural macrophage", "d": ["A border associated macrophage which is part of a dura matter. This macrophage phagocytoses intruding pathogens and foreign molecules detected in the bloodstream or in the cerebrospinal fluid. This cell has an amoeboid body with dynamic protrusions in homeostasis."], "t": []}], "preferred_name": "dural macrophage", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1513972", "l": "Neoplastic Germ Cell with Clear to Lightly Eosinophilic Cytoplasm", "d": [], "t": []}, {"i": "NCIT:C37130", "l": "Neoplastic Germ Cell with Clear to Lightly Eosinophilic Cytoplasm", "d": [], "t": []}], "preferred_name": "Neoplastic Germ Cell with Clear to Lightly Eosinophilic Cytoplasm", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1979669", "l": "Cells.CD19+IgG+", "d": [], "t": []}], "preferred_name": "Cells.CD19+IgG+", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5556653", "l": "WU-NK-101", "d": [], "t": []}, {"i": "NCIT:C180829", "l": "Allogeneic Cytokine-induced Memory-like NK Cells WU-NK-101", "d": ["A population of off-the-shelf (OTS) donor-derived cytokine-induced, memory-like, cytotoxic natural killer (NK) cells (CIML NKs) containing NK cell-activating surface receptors, with potential immunomodulating and antineoplastic activities. The allogeneic NK cells are pre-activated ex vivo using the human-derived cytokines interleukin (IL)-12, IL-15, and IL-18, which induces the differentiation of the NK cells into CIML NK cells, which contain more NK cell-activating surface receptors. The pretreated NK cells exhibit enhanced activation and increased production of the cytokine interferon-gamma (IFN-g), and may exert enhanced cytotoxicity against tumor cells, including enhanced antibody-dependent cellular cytotoxicity (ADCC). Upon administration, the CIML NKs WU-NK-101 may induce an anti-tumor immune response and kill tumor cells."], "t": []}], "preferred_name": "WU-NK-101", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4697022", "l": "CD27+CD45RO+CD62L+CCR7+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:1373240001", "l": "", "d": [], "t": []}], "preferred_name": "CD27+CD45RO+CD62L+CCR7+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0002176", "l": "secondary follicular cell of ovary", "d": ["A cell of a secondary follicile within the ovary."], "t": []}, {"i": "UMLS:C1182637", "l": "Secondary follicular cell of ovary", "d": [], "t": []}], "preferred_name": "secondary follicular cell of ovary", "taxa": []}
{"type": "biolink:Cell", "ic": 84.83823963392128, "identifiers": [{"i": "CL:0000190", "l": "fast muscle cell", "d": ["A muscle cell that can develop high tension rapidly. It is usually innervated by a single alpha neuron."], "t": []}], "preferred_name": "fast muscle cell", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "CL:0005004", "l": "pigment erythroblast", "d": ["A non-terminally differentiated cell that originates from the neural crest and differentiates into an erythrophore."], "t": []}], "preferred_name": "pigment erythroblast", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5549346", "l": "Cells.FOXP3 Ag", "d": [], "t": []}], "preferred_name": "Cells.FOXP3 Ag", "taxa": []}
{"type": "biolink:Cell", "ic": 67.84836621650341, "identifiers": [{"i": "UMLS:C1515964", "l": "Anaplastic Cell", "d": [], "t": []}, {"i": "NCIT:C36734", "l": "Anaplastic Cell", "d": [], "t": []}], "preferred_name": "Anaplastic Cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C2326979", "l": "Diffuse amacrine cell of retina", "d": [], "t": []}], "preferred_name": "Diffuse amacrine cell of retina", "taxa": []}
{"type": "biolink:Cell", "ic": 81.743421370964, "identifiers": [{"i": "UMLS:C1519602", "l": "Activated Skin-Homing T-Lymphocyte", "d": [], "t": []}, {"i": "NCIT:C39686", "l": "Activated Skin-Homing T-Lymphocyte", "d": ["A white blood cell, differentiated in the thymus, activated by an antigen that causes the cell to preferentially migrate to the skin."], "t": []}], "preferred_name": "Activated Skin-Homing T-Lymphocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 58.27410091832277, "identifiers": [{"i": "UMLS:C4527316", "l": "Chimeric Antigen Receptor T-cells", "d": [], "t": []}, {"i": "NCIT:C137999", "l": "Chimeric Antigen Receptor T-cells", "d": ["Autologous or allogeneic T-lymphocytes that are engineered to contain a chimeric antigen receptor (CAR) that specifically targets a particular antigen."], "t": []}], "preferred_name": "Chimeric Antigen Receptor T-cells", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1440399", "l": "Cells.t(11;14)(q13;q32)(CCND1,IGH)", "d": [], "t": []}], "preferred_name": "Cells.t(11;14)(q13;q32)(CCND1,IGH)", "taxa": []}
{"type": "biolink:Cell", "ic": 45.901560402635766, "identifiers": [{"i": "CL:0000187", "l": "muscle cell", "d": ["A mature contractile cell, commonly known as a myocyte. This cell has as part of its cytoplasm myofibrils organized in various patterns."], "t": []}, {"i": "UMLS:C0596981", "l": "Muscle Cells", "d": [], "t": []}, {"i": "NCIT:C12612", "l": "Muscle Cell", "d": ["A connective tissue cell with the ability to convert chemical energy into mechanical energy via a contractile apparatus. As part of the contractile apparatus, the proteins actin and myosin form parallel myofilaments. The interaction of actin and myosin mediates muscle cell contraction in response to stimulation of the excitable cell membrane."], "t": []}, {"i": "MESH:D032342", "l": "Muscle Cells", "d": [], "t": []}], "preferred_name": "muscle cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5170943", "l": "Leukocytes | Urine | Urinalysis", "d": [], "t": []}], "preferred_name": "Leukocytes | Urine | Urinalysis", "taxa": []}
{"type": "biolink:Cell", "ic": 88.20185721311867, "identifiers": [{"i": "CL:0000957", "l": "large pre-B-II cell", "d": ["A large pre-B-II cell is a pre-B-II cell that is proliferating and is Rag1-negative and Rag2-negative."], "t": []}], "preferred_name": "large pre-B-II cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1517817", "l": "Mouse Immature T-Lymphocyte", "d": [], "t": []}, {"i": "NCIT:C22579", "l": "Mouse Immature T-Lymphocyte", "d": [], "t": []}], "preferred_name": "Mouse Immature T-Lymphocyte", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5168977", "l": "Immature cells | Blood | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Immature cells | Blood | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": 56.29585370618632, "identifiers": [{"i": "CL:0000199", "l": "mechanoreceptor cell", "d": ["A cell specialized to transduce mechanical stimuli and relay that information centrally in the nervous system."], "t": []}], "preferred_name": "mechanoreceptor cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5666897", "l": "GDX012", "d": [], "t": []}, {"i": "NCIT:C182633", "l": "Allogeneic Variable Delta 1 Gamma-delta T-lymphocytes GDX012", "d": ["An off-the-shelf (OTS) preparation of allogeneic variable delta 1 (Vd1) gamma-delta (gd) T-lymphocytes, with potential immunomodulating and antineoplastic activities. Upon administration of the allogeneic Vd1 gd T-lymphocytes GDX012, these cells secrete interferon-gamma (IFN-g) and exert direct killing of tumor cells. In addition, these cells activate the immune system to exert a cytotoxic T-lymphocyte (CTL) response against tumor cells. Gamma delta T-lymphocytes play a key role in the activation of the immune system and do not require major histocompatibility complex (MHC)-mediated antigen presentation to exert their cytotoxic effect. Vd1 gd T-cells, a subset of gamma delta T-cells, recognize and are activated by cancer cells, and may therefore have a stronger association with antitumor immune responses compared with other gamma delta T-cell subtypes."], "t": []}], "preferred_name": "GDX012", "taxa": []}
{"type": "biolink:Cell", "ic": 92.76600187037766, "identifiers": [{"i": "CL:0000109", "l": "adrenergic neuron", "d": [], "t": []}], "preferred_name": "adrenergic neuron", "taxa": []}
{"type": "biolink:Cell", "ic": 89.40238429118027, "identifiers": [{"i": "CL:1001016", "l": "kidney loop of Henle ascending limb epithelial cell", "d": ["Any kidney loop of Henle epithelial cell that is part of some ascending limb of loop of Henle."], "t": []}], "preferred_name": "kidney loop of Henle ascending limb epithelial cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4052063", "l": "nail bed keratinocyte", "d": ["A keratinocyte that resides in the nail bed, responsible for tightly attaching the nail plate to the underlying dermis. Unlike typical epidermal keratinocytes, it exhibits limited proliferation, undergoes modified differentiation that skips the granular layer and conventional cornification, and primarily ensures adhesion and maintenance of the nail plate. In humans, this cell expresses characteristic markers, including the protease inhibitor SPINK6 and the differentiation-associated protein KRT16."], "t": []}], "preferred_name": "nail bed keratinocyte", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0222678", "l": "Undifferentiated mesenchymal cell", "d": [], "t": []}, {"i": "SNOMEDCT:75091002", "l": "", "d": [], "t": []}], "preferred_name": "Undifferentiated mesenchymal cell", "taxa": []}
{"type": "biolink:Cell", "ic": 86.30756602822301, "identifiers": [{"i": "CL:0002484", "l": "epithelial melanocyte", "d": ["A melanocyte that produces pigment in the epithelium."], "t": []}], "preferred_name": "epithelial melanocyte", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5175154", "l": "Nucleated cells | Synovial fluid | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Nucleated cells | Synovial fluid | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1518066", "l": "Lymphocyte with Abundant Pale Cytoplasm", "d": [], "t": []}, {"i": "NCIT:C37028", "l": "Lymphocyte with Abundant Pale Cytoplasm", "d": [], "t": []}], "preferred_name": "Lymphocyte with Abundant Pale Cytoplasm", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5177618", "l": "Platelets | Body fluid | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Platelets | Body fluid | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0682643", "l": "resting or wandering histiocyte", "d": [], "t": []}], "preferred_name": "resting or wandering histiocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:7770003", "l": "beam A cell", "d": ["A beam cell within the eye's trabecular meshwork, molecularly distinguished by FABP4 expression in humans and spatially intermingled with Beam B cells throughout the uveal and corneoscleral meshwork regions. In mice, a transcriptionally analogous Beam A–like cluster (mC14) exists, sharing core TM markers (Myoc, Mgp, Pdpn, Chil1) and functional attributes."], "t": []}], "preferred_name": "beam A cell", "taxa": []}
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{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5382753", "l": "CD18 cells | Blood | Cell markers", "d": [], "t": []}], "preferred_name": "CD18 cells | Blood | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5668443", "l": "Allogeneic Anti-CD33 CAR NK Cells", "d": [], "t": []}, {"i": "NCIT:C183523", "l": "Allogeneic Anti-CD33 CAR NK Cells", "d": ["A preparation of off-the-shelf natural killer (NK) cells engineered to express a chimeric antigen receptor (CAR) specific for the cluster of differentiation 33 (CD33) antigen, with potential immunostimulating and antineoplastic activities. Upon administration, the allogeneic anti-CD33 CAR NK cells target and bind to CD33 expressed on the surface of tumor cells. This induces selective toxicity in tumor cells expressing CD33. CD33 is expressed on normal non-pluripotent hematopoietic stem cells and on myeloid leukemia cells."], "t": []}], "preferred_name": "Allogeneic Anti-CD33 CAR NK Cells", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5818635", "l": "Allogeneic fluid containing peripheral blood stem cells", "d": [], "t": []}, {"i": "SNOMEDCT:1285505007", "l": "", "d": [], "t": []}], "preferred_name": "Allogeneic fluid containing peripheral blood stem cells", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "UMLS:C1517214", "l": "Flower-Like T-Lymphocyte", "d": [], "t": []}, {"i": "NCIT:C39682", "l": "Flower-Like T-Lymphocyte", "d": [], "t": []}], "preferred_name": "Flower-Like T-Lymphocyte", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C6008026", "l": "Oocyte of primary follicle", "d": [], "t": []}, {"i": "SNOMEDCT:1351745000", "l": "", "d": [], "t": []}], "preferred_name": "Oocyte of primary follicle", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5235879", "l": "EBV Immortalized Lymphocytes", "d": [], "t": []}, {"i": "NCIT:C163993", "l": "EBV Immortalized Lymphocytes", "d": ["A biospecimen consisting of lymphocytes that have been isolated from whole blood and are then infected in vitro by Epstein-Barr virus (EBV; HHV4). The infected cells are then cultured to select indefinitely proliferating colonies that can be maintained in tissue culture."], "t": []}], "preferred_name": "EBV Immortalized Lymphocytes", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C2355611", "l": "Suppressor effector T lymphocyte", "d": [], "t": []}, {"i": "NCIT:C12544", "l": "Suppressor-Effector T-Lymphocyte", "d": ["T-lymphocytes that respond to signals from suppressor-inducer T-cells by inhibiting either cell-mediated immunity or antibody production by B-cells."], "t": []}], "preferred_name": "Suppressor effector T lymphocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1512641", "l": "Immature Mesenchymal Spindle Cell", "d": [], "t": []}, {"i": "NCIT:C37120", "l": "Immature Mesenchymal Spindle Cell", "d": [], "t": []}], "preferred_name": "Immature Mesenchymal Spindle Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 58.40356238519053, "identifiers": [{"i": "UMLS:C1514083", "l": "Neoplastic Sex Cord-Stromal Cell", "d": [], "t": []}, {"i": "NCIT:C36898", "l": "Neoplastic Sex Cord-Stromal Cell", "d": [], "t": []}], "preferred_name": "Neoplastic Sex Cord-Stromal Cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5216190", "l": "Basophils|NCnc|Pt|Bld", "d": [], "t": []}], "preferred_name": "Basophils|NCnc|Pt|Bld", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5161803", "l": "Cytoplasmic CD3 blasts | XXX | Cell markers", "d": [], "t": []}], "preferred_name": "Cytoplasmic CD3 blasts | XXX | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:1001606", "l": "foreskin keratinocyte", "d": ["Keratinocyte from foreskin."], "t": []}], "preferred_name": "foreskin keratinocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 83.11065783093733, "identifiers": [{"i": "UMLS:C5856852", "l": "Anti-GD2 CAR T Cells Preparation", "d": [], "t": []}, {"i": "NCIT:C201491", "l": "Anti-GD2 CAR T Cells Preparation", "d": ["Any preparation of chimeric antigen receptor (CAR) expressing T-lymphocytes that targets the tumor-associated antigen (TAA) GD2."], "t": []}], "preferred_name": "Anti-GD2 CAR T Cells Preparation", "taxa": []}
{"type": "biolink:Cell", "ic": 69.94527858408269, "identifiers": [{"i": "UMLS:C1513927", "l": "Neoplastic B-Immunoblast", "d": [], "t": []}, {"i": "NCIT:C37010", "l": "Neoplastic B-Immunoblast", "d": [], "t": []}], "preferred_name": "Neoplastic B-Immunoblast", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0020032", "l": "oRGC2", "d": ["A conserved retinal ganglion cell orthotype whose transcriptomic profile groups together ON parasol RGCs from primate foveal and peripheral retina with their molecularly homologous mouse α RGC subtype (ON-transient α RGC, C41) (Hahn et al., 2023; Tran et al., 2019). Reference to the transcriptomic evidence is found at: GSE237215."], "t": []}], "preferred_name": "oRGC2", "taxa": []}
{"type": "biolink:Cell", "ic": 54.96431245846884, "identifiers": [{"i": "UMLS:C0242629", "l": "CD8-Positive T-Lymphocytes", "d": [], "t": []}, {"i": "NCIT:C12542", "l": "CD8-Positive T-Lymphocyte", "d": ["A subset of T-lymphocytes that express the CD8 surface glycoprotein and bind epitopes that are part of class I histocompatibility molecules. CD8-positive T-lymphocytes include cytotoxic T-lymphocytes and CD8+ suppressor T-lymphocytes."], "t": []}, {"i": "MESH:D018414", "l": "CD8-Positive T-Lymphocytes", "d": [], "t": []}, {"i": "SNOMEDCT:117539009", "l": "", "d": [], "t": []}], "preferred_name": "CD8-Positive T-Lymphocytes", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C4683473", "l": "Autologous Anti-CD19 Chimeric Antigen Receptor T-cells C-CAR011", "d": [], "t": []}, {"i": "NCIT:C141050", "l": "Autologous Anti-CD19 Chimeric Antigen Receptor T-cells C-CAR011", "d": ["A proprietary preparation of autologous T-lymphocytes that have been genetically modified and transduced with a lentiviral vector expressing a second-generation chimeric antigen receptor (CAR) targeting the tumor-associated antigen (TAA) CD19 and containing, as of yet undisclosed, costimulatory signaling domains, with potential immunostimulating and antineoplastic activities. Upon administration, autologous anti-CD19 CAR T-cells C-CAR011 target and bind to CD19-expressing tumor cells, thereby inducing selective toxicity in CD19-expressing tumor cells. CD19 antigen is a B-cell specific cell surface antigen expressed in all B-cell lineage malignancies."], "t": []}], "preferred_name": "Autologous Anti-CD19 Chimeric Antigen Receptor T-cells C-CAR011", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C2698131", "l": "Anti-CEA TCR Retroviral Vector-Transduced Autologous Peripheral Blood Lymphocytes", "d": [], "t": []}, {"i": "NCIT:C79842", "l": "Anti-CEA TCR Retroviral Vector-Transduced Autologous Peripheral Blood Lymphocytes", "d": ["Autologous human peripheral blood lymphocytes (PBLs), transduced with a retroviral vector encoding both the alpha and beta chains of a T cell receptor (TCR) specific for the carcinoembryonic antigen (CEA), with potential immunostimulating and antineoplastic activities. After transduction, expansion in culture, and reintroduction into the patient, anti-CEA TCR retroviral vector-transduced autologous lymphocytes bind to tumor cells expressing CEA, which may result in cytokine expression, activation and proliferation of T-cells, and a specific cytotoxic T-lymphocyte (CTL) response against CEA-expressing tumor cells. The tumor-associated antigen (TAA) CEA is overexpressed by a variety of cancer cell types, including those of the gastrointestinal tract, lung, and breast."], "t": []}], "preferred_name": "Anti-CEA TCR Retroviral Vector-Transduced Autologous Peripheral Blood Lymphocytes", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5177624", "l": "Platelets agranular | Blood | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Platelets agranular | Blood | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0000478", "l": "oxytocin stimulating hormone secreting cell", "d": ["A peptide hormone secreting cell that secretes oxytocin stimulating hormone"], "t": []}], "preferred_name": "oxytocin stimulating hormone secreting cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4052048", "l": "intercalated cell of salivary gland", "d": ["A cuboidal epithelial cell that is part of the intercalated duct of salivary gland. This cell expresses proteins commonly associated with acinar cells and displays calcium signaling characteristics similar to secretory cells, indicating an active role in the secretory process rather than ion reabsorption."], "t": []}], "preferred_name": "intercalated cell of salivary gland", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1511280", "l": "Bowenoid Cell", "d": [], "t": []}, {"i": "NCIT:C36755", "l": "Bowenoid Cell", "d": [], "t": []}], "preferred_name": "Bowenoid Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0000597", "l": "microconidium", "d": ["The smaller of two types of asexual spores formed by some fungi. An ovoid to pear-shaped asexual spore that contains very little cytoplasm and organelles, is uninucleate, and forms in vegetative hypae within a mycelium. Micronidia are extruded from the hyphal cell wall."], "t": []}], "preferred_name": "microconidium", "taxa": []}
{"type": "biolink:Cell", "ic": 53.36376296519504, "identifiers": [{"i": "UMLS:C1514005", "l": "Neoplastic Large Lymphocyte", "d": [], "t": []}, {"i": "NCIT:C37008", "l": "Neoplastic Large Lymphocyte", "d": [], "t": []}], "preferred_name": "Neoplastic Large Lymphocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0000425", "l": "pore cell", "d": ["Forms the terminal part of the cuticle-lined excretory duct of C. elegans."], "t": []}], "preferred_name": "pore cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5163548", "l": "Epithelial cells.extrarenal | Urine sediment | Urinalysis", "d": [], "t": []}], "preferred_name": "Epithelial cells.extrarenal | Urine sediment | Urinalysis", "taxa": []}
{"type": "biolink:Cell", "ic": 86.30756602822301, "identifiers": [{"i": "CL:0011003", "l": "magnocellular neurosecretory cell", "d": ["A neurosecretory neuron residing mainly in the hypothalamic supraoptic and paraventricular nuclei and in a number of smaller accessory cell groups between these two nuclei, that is capable of secreting the hormones oxytocin or vasopressin, and sometimes both, into the systemic circulation."], "t": []}], "preferred_name": "magnocellular neurosecretory cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0009054", "l": "microfold cell of epithelium proper of anorectum", "d": ["A microfold cell (M cell) that is part of the anorectum."], "t": []}], "preferred_name": "microfold cell of epithelium proper of anorectum", "taxa": []}
{"type": "biolink:Cell", "ic": 63.51261447292052, "identifiers": [{"i": "CL:0000746", "l": "cardiac muscle cell", "d": ["Cardiac muscle cells are striated muscle cells that are responsible for heart contraction. In mammals, the contractile fiber resembles those of skeletal muscle but are only one third as large in diameter, are richer in sarcoplasm, and contain centrally located instead of peripheral nuclei."], "t": []}, {"i": "UMLS:C0225828", "l": "Myocytes, Cardiac", "d": [], "t": []}, {"i": "NCIT:C13002", "l": "Cardiomyocyte", "d": ["A muscle cell in heart tissue (myocardium)."], "t": []}, {"i": "MESH:D032383", "l": "Myocytes, Cardiac", "d": [], "t": []}, {"i": "SNOMEDCT:86441007", "l": "", "d": [], "t": []}], "preferred_name": "cardiac muscle cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4033035", "l": "giant bipolar cell", "d": ["An ON bipolar cell that has large dendritic and axonal fields."], "t": []}], "preferred_name": "giant bipolar cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0002572", "l": "vertebral mesenchymal stem cell", "d": ["A mesenchymal stem cell of the vertebrae."], "t": []}], "preferred_name": "vertebral mesenchymal stem cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5170933", "l": "Leukocytes | Pericardial fluid | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Leukocytes | Pericardial fluid | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0882931", "l": "CD8+CD25+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:1373049007", "l": "", "d": [], "t": []}], "preferred_name": "CD8+CD25+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": 70.01422862627324, "identifiers": [{"i": "CL:4023038", "l": "L6b glutamatergic cortical neuron", "d": ["A glutamatergic neuron with a soma found in cortical layer 6b. They are transcriptomically related to corticothalamic-projecting neurons but have differential projections to the thalamus or anterior cingulate.", "A glutamatergic neuron with a soma found in cortical layer 6b. They are transcriptomically related to corticothalamic-projecting neurons but have differential projections to the thalamus or anterior cingulate. The standard transcriptomic reference data for this cell type can be found on the CellxGene census under the collection: 'Transcriptomic cytoarchitecture reveals principles of human neocortex organization', dataset: 'Supercluster: Deep layer (non-IT) excitatory neuron', Author Categories: 'CrossArea_subclass', cluster L6b."], "t": []}], "preferred_name": "L6b glutamatergic cortical neuron", "taxa": []}
{"type": "biolink:Cell", "ic": 83.11065783093733, "identifiers": [{"i": "UMLS:C1518244", "l": "Malignant Spindle Squamous Cell", "d": [], "t": []}, {"i": "NCIT:C36775", "l": "Malignant Spindle Squamous Cell", "d": [], "t": []}], "preferred_name": "Malignant Spindle Squamous Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0011105", "l": "dopamanergic interplexiform cell", "d": ["A type of interneuron in the retinal inner nuclear layer which\ncarries information from the inner plexiform layer and the outer\nplexiform layer, using dopamine."], "t": []}], "preferred_name": "dopamanergic interplexiform cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1440054", "l": "Abnormal blood cells.CD33", "d": [], "t": []}], "preferred_name": "Abnormal blood cells.CD33", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5157374", "l": "CD2+CD26+ cells | Blood | Cell markers", "d": [], "t": []}], "preferred_name": "CD2+CD26+ cells | Blood | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C4086542", "l": "Lentivirus Vector CCR5 shRNA/TRIM5alpha/TAR Decoy-transduced Autologous CD34-positive Hematopoietic Progenitor Cells", "d": [], "t": []}, {"i": "NCIT:C123931", "l": "Lentivirus Vector CCR5 shRNA/TRIM5alpha/TAR Decoy-transduced Autologous CD34-positive Hematopoietic Progenitor Cells", "d": ["Autologous, CD34-positive hematopoietic progenitor cells (HPCs) transduced with a lentiviral vector encoding three anti-human immunodeficiency virus (HIV) genes: a short hairpin RNA (shRNA) that targets human chemokine receptor 5 (CCR5), a human/rhesus macaque chimeric tripartite motif-containing protein 5 alpha isoform (TRIM5alpha), and a TAT activation response (TAR) decoy, as well as a pre-selective cell-surface marker, which is a truncated and mutated form of human CD25, used to potentially provide resistance against human immunodeficiency virus (HIV) infection. Human autologous CD34-positive HPCs are isolated and transduced ex vivo with the lentiviral vector. Upon pre-selection, purification using CD25 immunomagnetic separation, and subsequent administration of effectively transduced HPCs, the HPCs display 3 separate mechanisms of action against HIV infection: CCR5 shRNA binds to CCR5 mRNA and inhibits the expression of CCR5, a HIV-1 co-receptor that mediates HIV attachment and host cell entry; TRIM5alpha prevents HIV genome integration upon cell entry; and the TAR decoy binds to the HIV TAT protein and prevents TAT-dependent viral gene transcription, thereby preventing HIV replication. Upon transfer of the lentivirus vector CCR5 shRNA/TRIM5alpha/TAR decoy-transduced autologous CD34-positive HPCs into the patient, the HPCs are resistant to HIV entry and replication and could provide long-term protection against both HIV infection and HIV-associated cancers."], "t": []}], "preferred_name": "Lentivirus Vector CCR5 shRNA/TRIM5alpha/TAR Decoy-transduced Autologous CD34-positive Hematopoietic Progenitor Cells", "taxa": []}
{"type": "biolink:Cell", "ic": 84.83823963392128, "identifiers": [{"i": "CL:4023033", "l": "OFF retinal ganglion cell", "d": ["A retinal ganglion cell that is depolarized by decreased illumination of their receptive field center."], "t": []}], "preferred_name": "OFF retinal ganglion cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1440343", "l": "CD66a+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:1372922000", "l": "", "d": [], "t": []}], "preferred_name": "CD66a+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4246843", "l": "Cranial neural crest cell", "d": [], "t": []}], "preferred_name": "Cranial neural crest cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5206808", "l": "CD3+/CD19+ Cell-depleted Unrelated or Partially Matched Donor-derived Allogeneic Peripheral Blood Stem Cells", "d": [], "t": []}, {"i": "NCIT:C162765", "l": "CD3+/CD19+ Cell-depleted Unrelated or Partially Matched Donor-derived Allogeneic Peripheral Blood Stem Cells", "d": ["A preparation of allogeneic peripheral blood stem cells (PBSCs) from an unrelated or partially matched related donor that have been selectively depleted of CD3-positive  (CD3+) T-cells and CD19-positive (CD19+) B-cells via leukapheresis with potential immune reconstituting activity. The CD3+/CD19+ cell-depleted PBSCs are used for allogeneic hematopoietic cell transplantation (HCT) and may allow for rapid and sustained engraftment, immune reconstitution, and may prevent or reduce graft-versus-host disease (GvHD) and Epstein-Barr virus (EBV)-driven post-transplant lymphoproliferative disorders."], "t": []}], "preferred_name": "CD3+/CD19+ Cell-depleted Unrelated or Partially Matched Donor-derived Allogeneic Peripheral Blood Stem Cells", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4072042", "l": "L5/6 near-projecting glutamatergic neuron (Homo sapiens)", "d": ["A transcriptomically defined near-projecting glutamatergic neuron with a soma found in cortical layer 5/6 in humans."], "t": []}], "preferred_name": "L5/6 near-projecting glutamatergic neuron (Homo sapiens)", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0946500", "l": "CD4+CD45+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:1373109002", "l": "", "d": [], "t": []}], "preferred_name": "CD4+CD45+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5179521", "l": "Reticulocytes.high fluorescence/100 erythrocytes | Blood | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Reticulocytes.high fluorescence/100 erythrocytes | Blood | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4307102", "l": "MFOL NN_3 Cxcl12 myelin-forming oligodendrocyte (Mmus)", "d": ["A myelin-forming oligodendrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Opalin (Mmus), Cxcl12 (Mmus), Efhd1 (Mmus). It is distinguished from other MFOL NN_3 cells by expression of Cxcl12, Efhd1. These cells are located in the Isocortex, brain . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5282 MFOL NN_3."], "t": []}], "preferred_name": "MFOL NN_3 Cxcl12 myelin-forming oligodendrocyte (Mmus)", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4079007", "l": "cervical dorsal root ganglion substance P neuron", "d": ["A peptidergic nociceptor whose soma is located in the cervical dorsal root ganglion and that expresses substance P, an 11-amino-acid neuropeptide cleaved from protachykinin-1 (encoded by TAC1). This small-diameter neuron frequently co-expresses CGRP and belongs to the TrkA-positive peptidergic population. Upon nociceptive activation, it releases substance P both centrally in the spinal cord dorsal horn and peripherally at sensory nerve terminals, mediating neurogenic inflammation through NK1 receptor signalling (Haberberger et al. 2019, PMID:31293388). Substance P-immunoreactive neurons have been consistently identified in human DRG by immunohistochemistry across multiple studies."], "t": []}], "preferred_name": "cervical dorsal root ganglion substance P neuron", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4023187", "l": "koniocellular cell", "d": ["A neuron with a small cell body that is located in a koniocellular layer of the lateral geniculate nucleus (LGN)."], "t": []}], "preferred_name": "koniocellular cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5783871", "l": "Allogeneic Anti-HA-2 TCR-engineered T-cells TSC-101", "d": [], "t": []}, {"i": "NCIT:C190705", "l": "Allogeneic Anti-HA-2 TCR-engineered T-cells TSC-101", "d": ["A preparation of donor-derived T-lymphocytes that have been genetically engineered to express a T-cell receptor (TCR) specific for HLA-A*02:01-restricted minor histocompatibility antigen HA-2 (HA2), with potential immunomodulating and antineoplastic activities. Following allogeneic haploidentical hematopoietic cell transplantation (HCT) in HLA-A*02:01 positive patients, allogeneic anti-HA-2 TCR-engineered T-cells TSC-101 specifically recognize and bind to HA-2 expressed on tumor cells. This may lead to cytotoxic T-lymphocyte (CTL)-mediated elimination of tumor cells expressing HA-2. HA-2 is a lineage-specific antigen found on leukemia cells."], "t": []}], "preferred_name": "Allogeneic Anti-HA-2 TCR-engineered T-cells TSC-101", "taxa": []}
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{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4047052", "l": "BEST4+ colonocyte", "d": ["An enterocyte of the human colon expressing bestrophin-4 (BEST4) calcium-activated ion channels.  These cells have a distinct transcriptomic profile compared to other enterocytes and are scattered through the colon epithelium."], "t": []}], "preferred_name": "BEST4+ colonocyte", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0229644", "l": "Nonsegmented eosinophil", "d": [], "t": []}, {"i": "SNOMEDCT:81209003", "l": "", "d": [], "t": []}], "preferred_name": "Nonsegmented eosinophil", "taxa": []}
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{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5157450", "l": "CD3+CD56+ cells | Bone marrow | Cell markers", "d": [], "t": []}], "preferred_name": "CD3+CD56+ cells | Bone marrow | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C0033416", "l": "Promyelocytes", "d": [], "t": []}, {"i": "NCIT:C13114", "l": "Promyelocyte", "d": ["A cell of the bone marrow that is derived from myeloblasts and will give rise to myelocytes, precursors of myeloid cells and neutrophil granulocytes."], "t": []}, {"i": "SNOMEDCT:43446009", "l": "", "d": [], "t": []}], "preferred_name": "Promyelocytes", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0333847", "l": "Mott plasma cell", "d": [], "t": []}, {"i": "SNOMEDCT:83718009", "l": "", "d": [], "t": []}], "preferred_name": "Mott plasma cell", "taxa": []}
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{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4322813", "l": "CD44+ T lymphocyte", "d": [], "t": []}], "preferred_name": "CD44+ T lymphocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0002580", "l": "preadipocyte of the breast", "d": ["A preadipocyte that is part of the breast."], "t": []}], "preferred_name": "preadipocyte of the breast", "taxa": []}
{"type": "biolink:Cell", "ic": 70.82453858732072, "identifiers": [{"i": "CL:0000798", "l": "gamma-delta T cell", "d": ["A T cell that expresses a gamma-delta T cell receptor complex."], "t": []}], "preferred_name": "gamma-delta T cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1545462", "l": "CD19+CD103+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:1372974002", "l": "", "d": [], "t": []}], "preferred_name": "CD19+CD103+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1518009", "l": "Low Columnar Cell", "d": [], "t": []}, {"i": "NCIT:C33008", "l": "Low Columnar Cell", "d": ["A simple epithelial cell that is shaped like a short column."], "t": []}], "preferred_name": "Low Columnar Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 82.16838616155795, "identifiers": [{"i": "CL:0000173", "l": "pancreatic D cell", "d": ["A D cell located in the pancreas. Peripherally placed within the islets like type A cells; contains somatostatin."], "t": []}], "preferred_name": "pancreatic D cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1513952", "l": "Neoplastic Endocrine Chief Cell", "d": [], "t": []}, {"i": "NCIT:C36938", "l": "Neoplastic Endocrine Chief Cell", "d": [], "t": []}], "preferred_name": "Neoplastic Endocrine Chief Cell", "taxa": []}
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{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5454853", "l": "Not specified MC", "d": [], "t": []}], "preferred_name": "Not specified MC", "taxa": []}
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{"type": "biolink:Cell", "ic": 66.26039393006171, "identifiers": [{"i": "UMLS:C1708370", "l": "Histiocytic and Dendritic Cell", "d": [], "t": []}, {"i": "NCIT:C43251", "l": "Histiocytic and Dendritic Cell", "d": ["A grouping of hematopoietic cells derived from monocytes."], "t": []}], "preferred_name": "Histiocytic and Dendritic Cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0221282", "l": "Schistocyte", "d": [], "t": []}, {"i": "SNOMEDCT:70310009", "l": "", "d": [], "t": []}], "preferred_name": "Schistocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "UMLS:C1522050", "l": "Granular Adenocarcinoma Cell", "d": [], "t": []}, {"i": "NCIT:C36840", "l": "Granular Adenocarcinoma Cell", "d": [], "t": []}], "preferred_name": "Granular Adenocarcinoma Cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4253015", "l": "Set of type D cells of pancreatic islet", "d": [], "t": []}], "preferred_name": "Set of type D cells of pancreatic islet", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1179516", "l": "Epithelial cell of pancreas", "d": [], "t": []}], "preferred_name": "Epithelial cell of pancreas", "taxa": []}
{"type": "biolink:Cell", "ic": 85.53200374075534, "identifiers": [{"i": "CL:0002309", "l": "corticotroph", "d": ["A basophil chromphil cell of the anterior pitiutary gland that produce adrenocorticotropic hormone, melanocyte-stimulating hormone and lipotropin. This cell type is irregular in shape and has short dendritic processes which are inserted among other neighboring cells;"], "t": []}, {"i": "UMLS:C1707524", "l": "Corticotroph", "d": [], "t": []}, {"i": "NCIT:C32390", "l": "Corticotroph Cell", "d": [], "t": []}, {"i": "MESH:D052680", "l": "Corticotrophs", "d": [], "t": []}, {"i": "SNOMEDCT:113332000", "l": "", "d": [], "t": []}], "preferred_name": "corticotroph", "taxa": []}
{"type": "biolink:Cell", "ic": 87.18682603146104, "identifiers": [{"i": "CL:0000871", "l": "splenic macrophage", "d": ["A secondary lymphoid organ macrophage found in the spleen."], "t": []}, {"i": "UMLS:C2337419", "l": "Splenic macrophage", "d": [], "t": []}], "preferred_name": "splenic macrophage", "taxa": []}
{"type": "biolink:Cell", "ic": 70.51821968886674, "identifiers": [{"i": "UMLS:C1518268", "l": "Malignant Neuroblast", "d": [], "t": []}, {"i": "NCIT:C37145", "l": "Malignant Neuroblast", "d": [], "t": []}], "preferred_name": "Malignant Neuroblast", "taxa": []}
{"type": "biolink:Cell", "ic": 84.83823963392128, "identifiers": [{"i": "CL:4300360", "l": "olfactory areas astrocyte (Mmus)", "d": ["A transcriptomically defined type of astrocyte located exclusively in the olfactory areas. It is distinguished from other cells in the brain by selective expression of Gja1 (Mmus), Hs3st3a1 (Mmus). Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Subclass:320 Astro-OLF NN."], "t": []}], "preferred_name": "olfactory areas astrocyte (Mmus)", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5157538", "l": "CD4+CD25+CD45RA+CD127Low+ cells | Blood | Cell markers", "d": [], "t": []}], "preferred_name": "CD4+CD25+CD45RA+CD127Low+ cells | Blood | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5237220", "l": "CTX110", "d": [], "t": []}, {"i": "NCIT:C165492", "l": "Allogeneic CRISPR-Cas9 Engineered Anti-CD19 CAR T Cells CTX110", "d": ["A preparation of human allogeneic T-lymphocytes transduced with a chimeric antigen receptor (CAR) specific for the tumor-associated antigen (TAA) CD19 and gene-edited with the clustered regularly interspaced short palindromic repeats (CRISPR)-Cas9 nuclease complex to eliminate endogenous TCR, with potential immunostimulating and antineoplastic activities. Upon introduction into the patient, the allogeneic CRISPR-Cas9 engineered anti-CD19 CAR T-cells CTX110 recognize and bind to CD19-overexpressing tumor cells. This may result in a specific cytotoxic T-lymphocyte (CTL)-mediated killing of CD19-positive tumor cells. Removal of endogenous TCR reduces the risk of graft-versus-host disease (GvHD). CD19 antigen is a B-cell specific cell surface antigen expressed in all B-cell lineage malignancies."], "t": []}], "preferred_name": "CTX110", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5667000", "l": "Autologous CD34+-enriched HSPCs Transduced with LV Vector Carrying TCIRG1 Gene RP-L401", "d": [], "t": []}, {"i": "NCIT:C185445", "l": "Autologous CD34+-enriched HSPCs Transduced with LV Vector Carrying TCIRG1 Gene RP-L401", "d": ["A preparation of autologous CD34+-enriched hematopoietic stem and progenitor cells (HSPCs) from mobilized peripheral blood of patients with infantile malignant osteopetrosis (IMO) that are transduced ex vivo with a lentiviral (LV) vector carrying the T cell immune regulator 1 (TCIRG1) gene, with potential to restore TCIRG1 expression and function. Upon re-infusion of autologous CD34+-enriched HSPCs transduced with LV vector carrying TCIRG1 gene RP-L401 back into the patient, these cells express functional TCIRG1 gene. Mutations in the TCIRG1 gene, found in some patients with IMO, lead to functional impairment of the proton pump of the osteoclast."], "t": []}], "preferred_name": "Autologous CD34+-enriched HSPCs Transduced with LV Vector Carrying TCIRG1 Gene RP-L401", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0020014", "l": "intrinsically photosensitive retinal ganglion cell", "d": ["A retinal ganglion cell that is intrinsically photosensitive, functioning as a non-image-forming photoreceptor, distinguished from rod and cone photoreceptors by the expression of the photopigment melanopsin in mice and humans (Hattar et al., 2002; Tri Hoang Do & Yau, 2015). Located primarily in the ganglion cell layer with some displaced somata in the inner nuclear layer, this neuron depolarises directly in response to environmental irradiance (Tri Hoang Do & Yau, 2015). It projects via the retinohypothalamic tract to central targets, including the suprachiasmatic nucleus (SCN) for circadian photoentrainment and the olivary pretectal nucleus (OPN) for the pupillary light reflex."], "t": []}], "preferred_name": "intrinsically photosensitive retinal ganglion cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5554856", "l": "Donor Derived HIV-Specific T-cells with Non-escaped Epitope Targets", "d": [], "t": []}, {"i": "NCIT:C178128", "l": "Donor Derived HIV-Specific T-cells with Non-escaped Epitope Targets", "d": ["A preparation of ex vivo expanded donor-derived (DD) human immunodeficiency virus (HIV)-specific T-cells (HSTs) with non-escaped epitope targets (NEETs), that can potentially be used to eliminate HIV-infected cells and eradicate HIV. Upon administration, DD HST-NEETs target and kill HIV-infected cells, thereby eradicating HIV. HST-NEETs recognize multiple conserved, non-escaped HIV epitopes and their common variants, which is important in killing latently infected cells and could reduce viral escape."], "t": []}], "preferred_name": "Donor Derived HIV-Specific T-cells with Non-escaped Epitope Targets", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1979665", "l": "CD19+CD43+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:1372983007", "l": "", "d": [], "t": []}], "preferred_name": "CD19+CD43+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C4329367", "l": "Autologous Anti-MG7-CAR T-Lymphocytes", "d": [], "t": []}, {"i": "NCIT:C131493", "l": "Autologous Anti-MG7-CAR T-Lymphocytes", "d": ["A preparation of autologous, engineered T-lymphocytes that express both a second-generation chimeric antigen receptor (CAR) specific for the human gastric carcinoma-associated antigen MG7, and the co-stimulatory molecule 4-1BB (CD137), with potential antineoplastic activity. Upon intratumoral injection, the autologous anti-MG7-CAR T-lymphocytes target and attach to cancer cells expressing MG7. This induces selective toxicity in and causes lysis of MG7-expressing tumor cells. MG7, a glycosylated protein sequence from the tumor-associated antigen (TAA) carcinoembryonic antigen (CEA), plays a key role in the development of certain tumor cell types. 4-1BB enhances T-cell activation and signaling after recognition of MG7."], "t": []}], "preferred_name": "Autologous Anti-MG7-CAR T-Lymphocytes", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0545060", "l": "Peripheral blood (P.B.), abnormal cell", "d": [], "t": []}], "preferred_name": "Peripheral blood (P.B.), abnormal cell", "taxa": []}
{"type": "biolink:Cell", "ic": 92.76600187037766, "identifiers": [{"i": "UMLS:C1711380", "l": "Neoplastic Medium to Large Size Erythroblast", "d": [], "t": []}, {"i": "NCIT:C43218", "l": "Neoplastic Medium to Large Size Erythroblast", "d": [], "t": []}], "preferred_name": "Neoplastic Medium to Large Size Erythroblast", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1514654", "l": "RL05", "d": [], "t": []}, {"i": "NCIT:C20288", "l": "RL05", "d": ["Provider: Reliance Life Sciences, Mumbai, India. No information from provider. This cell line meets the criteria for the use of human embryonic stem cells by federally funded researchers."], "t": []}], "preferred_name": "RL05", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1515141", "l": "T-Prolymphocyte", "d": [], "t": []}, {"i": "NCIT:C33927", "l": "T-Prolymphocyte", "d": ["A medium sized round lymphocyte in the T-lymphocyte series, intermediate between the T-lymphoblast and the mature T-cell."], "t": []}], "preferred_name": "T-Prolymphocyte", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4322828", "l": "Set of corpuscles of colostrum", "d": [], "t": []}], "preferred_name": "Set of corpuscles of colostrum", "taxa": []}
{"type": "biolink:Cell", "ic": 89.40238429118027, "identifiers": [{"i": "CL:0000831", "l": "mast cell progenitor", "d": ["A progenitor cell of the mast cell lineage. Markers for this cell are FceRIa-low, CD117-positive, CD9-positive, T1/ST2-positive, SCA1-negative, and lineage-negative."], "t": []}], "preferred_name": "mast cell progenitor", "taxa": []}
{"type": "biolink:Cell", "ic": 89.40238429118027, "identifiers": [{"i": "CL:4301573", "l": "DCO Il22 Gly-Gaba_3 cerebellar neuron (Mmus)", "d": ["A cerebellar neuron of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Fat2 (Mmus), Slc6a5 (Mmus), Cgnl1 (Mmus). Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Supertype:1143 DCO Il22 Gly-Gaba_3."], "t": []}], "preferred_name": "DCO Il22 Gly-Gaba_3 cerebellar neuron (Mmus)", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5216214", "l": "Erythrocytes|NCnc|Pt|Dial fld prt", "d": [], "t": []}], "preferred_name": "Erythrocytes|NCnc|Pt|Dial fld prt", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C3896803", "l": "NK-92 cells", "d": [], "t": []}, {"i": "NCIT:C117231", "l": "Allogeneic Natural Killer Cell Line NK-92", "d": ["A proprietary, human cytotoxic cell line composed of allogeneic, activated, interleukin-2 (IL-2) dependent-natural killer cells derived from a 50-year old male patient with rapidly progressive non-Hodgkin's lymphoma, with potential antineoplastic activity. As NK-92 cells are devoid of killer inhibitory receptors (KIRs; also called killer cell immunoglobulin-like receptors), which are negative regulators of NK cell activity, cancer cells are unable to suppress the cancer cell killing ability of the NK-92 cells. Upon infusion of the allogeneic NK cell line NK-92, the NKs recognize and bind to tumor cells. This leads to the secretion and release of perforins, granzymes, cytokines and chemokines, which results in cancer cell lysis and apoptosis. In addition, NK-92 cells express high affinity Fc receptors, which bind to therapeutic antibodies; therefore, this agent can enhance antibody dependent cellular cytotoxicity (ADCC) of co-administered therapeutic antibodies."], "t": []}], "preferred_name": "NK-92 cells", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C4727163", "l": "Autologous Tumor Infiltrating Lymphocytes MDA-TIL", "d": [], "t": []}, {"i": "NCIT:C153312", "l": "Autologous Tumor Infiltrating Lymphocytes MDA-TIL", "d": ["A preparation of autologous tumor infiltrating lymphocytes (TILs) with potential antineoplastic activity. TILs are isolated from a patient's tumor tissue, then cultured and expanded in vitro in the presence of interleukin-2 (IL-2) and an agonistic anti-4-1BB (CD137) antibody. Upon infusion of the autologous expanded TILs back into the patient, the cells specifically recognize, target, and kill the patient's tumor cells."], "t": []}], "preferred_name": "Autologous Tumor Infiltrating Lymphocytes MDA-TIL", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1267871", "l": "Lymphoblast positive for CD13 antigen", "d": [], "t": []}, {"i": "SNOMEDCT:117550007", "l": "", "d": [], "t": []}], "preferred_name": "Lymphoblast positive for CD13 antigen", "taxa": []}
{"type": "biolink:Cell", "ic": 85.53200374075534, "identifiers": [{"i": "UMLS:C1519381", "l": "Neoplastic Small to Medium-Sized B-Lymphocyte with Pale Cytoplasm", "d": [], "t": []}, {"i": "NCIT:C36991", "l": "Neoplastic Small to Medium-Sized B-Lymphocyte with Pale Cytoplasm", "d": [], "t": []}], "preferred_name": "Neoplastic Small to Medium-Sized B-Lymphocyte with Pale Cytoplasm", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0020051", "l": "descending interneuron of myenteric plexus", "d": ["An interneuron of the myenteric plexus whose axon projects aborally (in the descending direction) along the gut axis. This neuron class encompasses multiple chemically diverse subtypes including serotonergic (5-HT+), nitrergic (NOS1+), and other populations, forming the inhibitory limb of descending reflex pathways."], "t": []}], "preferred_name": "descending interneuron of myenteric plexus", "taxa": []}
{"type": "biolink:Cell", "ic": 92.76600187037766, "identifiers": [{"i": "CL:0000712", "l": "stratum granulosum cell", "d": ["Any epidermal cell that is part of some stratum granulosum of epidermis."], "t": []}], "preferred_name": "stratum granulosum cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5556468", "l": "Short Hairpin RNA-IL-6 Gene Silencing Anti-CD19 CAR T Cells", "d": [], "t": []}, {"i": "NCIT:C180570", "l": "Short Hairpin RNA-IL-6 Gene Silencing Anti-CD19 CAR T Cells", "d": ["A preparation of T-lymphocytes that have been genetically modified to express a chimeric antigen receptor (CAR) targeting the tumor-associated antigen (TAA) CD19 and containing a short hairpin RNA (shRNA) against the pro-inflammatory cytokine interleukin-6 (IL-6), and linked to the intracellular signaling domains of 4-1BB (CD137) and the zeta chain of the TCR/CD3 complex (TCRzeta; CD247; CD3zeta), with potential immunostimulating and antineoplastic activities. Upon administration, short hairpin RNA-IL-6 gene silencing anti-CD19 CAR T cells target and bind to CD19-expressing tumor cells, thereby inducing selective toxicity in CD19-expressing tumor cells. CD19 antigen is a B-cell specific cell surface antigen expressed in all B-cell lineage malignancies. IL-6 gene silencing reduces IL-6 gene expression and release. This may inhibit IL-6-mediated toxicity due to high IL-6 levels and may prevent severe cytokine release syndrome (CRS) and CAR-T-related encephalopathy (CRES)."], "t": []}], "preferred_name": "Short Hairpin RNA-IL-6 Gene Silencing Anti-CD19 CAR T Cells", "taxa": []}
{"type": "biolink:Cell", "ic": 72.71882977221638, "identifiers": [{"i": "UMLS:C4528422", "l": "NCI-60 Cell Line", "d": [], "t": []}, {"i": "NCIT:C139309", "l": "NCI-60 Cell Line", "d": ["A panel of 60 different human cancer cell lines grown in culture that were selected to be used in a drug-screening program to identify and characterize novel compounds for growth inhibition or killing of tumor cell lines."], "t": []}], "preferred_name": "NCI-60 Cell Line", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1515147", "l": "TE04 Cell Line", "d": [], "t": []}, {"i": "NCIT:C20299", "l": "TE04", "d": ["Provider: Technion University, Haifa, Israel. No information from provider. This cell line meets the criteria for the use of human embryonic stem cells by federally funded researchers."], "t": []}], "preferred_name": "TE04 Cell Line", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4033092", "l": "CD57-positive enterocyte", "d": ["An enterocyte that is part of a duodenal epithelium and expresses beta-1,3-glucuronyltransferase 1 (B3GAT1), also known as CD57 or HNK-1."], "t": []}], "preferred_name": "CD57-positive enterocyte", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1267868", "l": "Lymphocyte positive for CD11C antigen", "d": [], "t": []}, {"i": "SNOMEDCT:116849005", "l": "", "d": [], "t": []}], "preferred_name": "Lymphocyte positive for CD11C antigen", "taxa": []}
{"type": "biolink:Cell", "ic": 75.08236434612573, "identifiers": [{"i": "CL:0000696", "l": "PP cell", "d": ["A cell that stores and secretes pancreatic polypeptide hormone."], "t": []}, {"i": "UMLS:C2333944", "l": "Type PP enteroendocrine cell", "d": [], "t": []}], "preferred_name": "PP cell", "taxa": []}
{"type": "biolink:Cell", "ic": 86.30756602822301, "identifiers": [{"i": "CL:1001517", "l": "stomach enteroendocrine cell", "d": ["The various hormone- or neurotransmitter-secreting cells present throughout the mucosa of the stomach."], "t": []}], "preferred_name": "stomach enteroendocrine cell", "taxa": []}
{"type": "biolink:Cell", "ic": 69.87704306295657, "identifiers": [{"i": "UMLS:C1881580", "l": "Malignant Neuroendocrine Small Round Cell", "d": [], "t": []}, {"i": "NCIT:C47805", "l": "Malignant Neuroendocrine Small Round Cell", "d": [], "t": []}], "preferred_name": "Malignant Neuroendocrine Small Round Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4310113", "l": "SN GATA3-PVALB GABA GABAergic neuron (Primate)", "d": ["A GABAergic neuron of the Primates brain. These cells are located in the substantia nigra . Reference transcriptomic data for this type can be found in the dataset/taxonomy - HMBA Basal Ganglia Consensus Taxonomy in cell set Group:SN GATA3-PVALB GABA."], "t": []}], "preferred_name": "SN GATA3-PVALB GABA GABAergic neuron (Primate)", "taxa": []}
{"type": "biolink:Cell", "ic": 89.40238429118027, "identifiers": [{"i": "UMLS:C1708923", "l": "Malignant Transitional Cell with Eccentrically Placed Large Nucleus and Small Nucleolus", "d": [], "t": []}, {"i": "NCIT:C54555", "l": "Malignant Transitional Cell with Eccentrically Placed Large Nucleus and Small Nucleolus", "d": [], "t": []}], "preferred_name": "Malignant Transitional Cell with Eccentrically Placed Large Nucleus and Small Nucleolus", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5171666", "l": "Lymphocytes | Semen | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Lymphocytes | Semen | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4310138", "l": "STRv D2 medium spiny neuron (Primate)", "d": ["A nucleus accumbens shell and olfactory tubercle D2 medium spiny neuron of the Primates brain. These cells are located in the striatum . Reference transcriptomic data for this type can be found in the dataset/taxonomy - HMBA Basal Ganglia Consensus Taxonomy in cell set Group:STRv D2 MSN."], "t": []}], "preferred_name": "STRv D2 medium spiny neuron (Primate)", "taxa": []}
{"type": "biolink:Cell", "ic": 76.78008365410358, "identifiers": [{"i": "CL:4023121", "l": "sst chodl GABAergic interneuron", "d": ["A transcriptomically distinct sst GABAergic interneuron that also expresses Chodl. These neurons are rare and correspond to the only known interneurons with long-range projection.", "A transcriptomically distinct sst GABAergic cortical interneuron that also expresses Chodl. These neurons are rare and correspond to the only known cortical interneurons with long-range projection. The standard transcriptomic reference data for this cell type can be found on the CellxGene census under the collection: 'Transcriptomic cytoarchitecture reveals principles of human neocortex organization', dataset: 'Supercluster: MGE-derived interneurons', Author Categories: 'CrossArea_subclass', clusters Sst Chodl."], "t": []}], "preferred_name": "sst chodl GABAergic interneuron", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5184396", "l": "Unidentified cells | Body fluid | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Unidentified cells | Body fluid | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0546499", "l": "P.B. plasma cell", "d": [], "t": []}], "preferred_name": "P.B. plasma cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1440235", "l": "CD103+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:725327006", "l": "", "d": [], "t": []}], "preferred_name": "CD103+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0002415", "l": "immature Vgamma1.1-positive, Vdelta6.3-positive thymocyte", "d": ["A Vgamma1.1-positive, Vdelta6.3-positive thymocyte that is CD24-positive."], "t": []}], "preferred_name": "immature Vgamma1.1-positive, Vdelta6.3-positive thymocyte", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5166508", "l": "Hematopoietic progenitor cells | Blood | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Hematopoietic progenitor cells | Blood | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4310084", "l": "striatal LAMP5 CXCL14 GABAergic interneuron (Primate)", "d": ["A lamp5 GABAergic interneuron of the Primates brain. These cells are located in the striatum . Reference transcriptomic data for this type can be found in the dataset/taxonomy - HMBA Basal Ganglia Consensus Taxonomy in cell set Group:LAMP5-CXCL14 GABA."], "t": []}], "preferred_name": "striatal LAMP5 CXCL14 GABAergic interneuron (Primate)", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4033125", "l": "lumbar ganglion NPY neuron", "d": ["A sympathetic neuron that has the soma located in the lumbar ganglion and expresses the marker neuropeptide Y (NPY)."], "t": []}], "preferred_name": "lumbar ganglion NPY neuron", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0005008", "l": "macular hair cell", "d": ["An auditory hair cell located in the macula that is sensitive to auditory stimuli."], "t": []}], "preferred_name": "macular hair cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4033142", "l": "submandibular ganglion VIP/PHI neuron", "d": ["A parasympathetic neuron that has the soma located in the submandibular ganglion and expresses the marker vasoactive intestinal peptide (VIP) and peptide histidine isoleucine (PHI)."], "t": []}], "preferred_name": "submandibular ganglion VIP/PHI neuron", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C2326121", "l": "Golgi neuron", "d": [], "t": []}], "preferred_name": "Golgi neuron", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1292097", "l": "IgA B lymphocyte", "d": [], "t": []}, {"i": "SNOMEDCT:115603005", "l": "", "d": [], "t": []}], "preferred_name": "IgA B lymphocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0002629", "l": "mature microglial cell", "d": ["A mature microglial cell that has changed shape to an amoeboid morphology and is capable of cytokine production and antigen presentation."], "t": []}], "preferred_name": "mature microglial cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1955255", "l": "Erythrocyte clumps", "d": [], "t": []}], "preferred_name": "Erythrocyte clumps", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5856190", "l": "TRAC Locus Integrated Anti-CD19 19(T2)28z1xx CAR-T Cells", "d": [], "t": []}, {"i": "NCIT:C200264", "l": "TRAC Locus Integrated Anti-CD19 19(T2)28z1xx CAR-T Cells", "d": ["A preparation of T-lymphocytes that have been genetically modified to express a chimeric antigen receptor (CAR) targeting the tumor-associated antigen (TAA) CD19, linked to the co-stimulatory intracellular signaling domains of CD28 and the zeta chain of the TCR/CD3 complex (CD3-zeta) (CD28zeta; CD28z), and inserted into the T-cell receptor alpha constant (TRAC) locus, with potential immunostimulating and antineoplastic activities. Upon administration, the TRAC locus integrated anti-CD19 19(T2)28z1xx CAR-T cells specifically recognize and bind to CD19-expressing tumor cells, resulting in specific T-cell-mediated tumor cell lysis. CD19 antigen is a B-cell specific cell surface antigen overexpressed in B-cell lineage malignancies. CD28 and CD3zeta provide co-stimulatory activity and may enhance the cytotoxic effect and anti-tumor activity of the CAR T-cells. The 19(T2)28z1xx CAR includes a 1928zeta mutant, 1xx, which contains one instead of all three immunoreceptor tyrosine-based activation motifs (iTAMs). This may help prevent counterproductive T-cell differentiation and exhaustion. Integrating the anti-CD19 CAR to the TRAC locus may enhance both T-cell potency and the re-expression of the CAR following exposure to antigen."], "t": []}], "preferred_name": "TRAC Locus Integrated Anti-CD19 19(T2)28z1xx CAR-T Cells", "taxa": []}
{"type": "biolink:Cell", "ic": 82.62268137420203, "identifiers": [{"i": "UMLS:C1522074", "l": "Mouse Melanocyte", "d": [], "t": []}, {"i": "NCIT:C22543", "l": "Mouse Melanocyte", "d": [], "t": []}], "preferred_name": "Mouse Melanocyte", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5216221", "l": "Granulocytes|NCnc|Pt|Bld", "d": [], "t": []}], "preferred_name": "Granulocytes|NCnc|Pt|Bld", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "UMLS:C4055262", "l": "Central Memory Immune Cell", "d": [], "t": []}, {"i": "NCIT:C122730", "l": "Central Memory Immune Cell", "d": ["A population of long-lived antigen-specific immune cells, usually T-lymphocytes expressing CD45RO, L-selectin and CCR7, that are maintained by the immune system. Upon subsequent exposure to their target antigen, these cells rapidly proliferate and differentiate into effector cells."], "t": []}], "preferred_name": "Central Memory Immune Cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5426632", "l": "CD3+CD14-CD45+DOCK8+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:1373223005", "l": "", "d": [], "t": []}], "preferred_name": "CD3+CD14-CD45+DOCK8+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "CL:0002303", "l": "pigmented ciliary epithelial cell", "d": ["A cell that is part of pigmented ciliary epithelium. This cell type uptakes sodium and chloride ions from stromal interstitium and passes the ions to non-pigmented ciliary epithelial cells via gap junctions."], "t": []}, {"i": "UMLS:C1182646", "l": "Pigmented ciliary epithelial cell", "d": [], "t": []}], "preferred_name": "pigmented ciliary epithelial cell", "taxa": []}
{"type": "biolink:Cell", "ic": 72.11981073685999, "identifiers": [{"i": "UMLS:C1708888", "l": "Malignant Lipocyte", "d": [], "t": []}, {"i": "NCIT:C48877", "l": "Malignant Lipocyte", "d": [], "t": []}], "preferred_name": "Malignant Lipocyte", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5174625", "l": "Neutrophils | Synovial fluid | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Neutrophils | Synovial fluid | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4307068", "l": "Tanycyte NN_2 Otx2 tanycyte (Mmus)", "d": ["A tanycyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Ccdc146 (Mmus), Tbx3 (Mmus), Otx2 (Mmus). It is distinguished from other Tanycyte NN_2 cells by expression of Otx2, Nkx2-4. These cells are located in the Hypothalamus, brain , in or close to the regions: Periventricular hypothalamic nucleus, posterior part, third ventricle . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5248 Tanycyte NN_2."], "t": []}], "preferred_name": "Tanycyte NN_2 Otx2 tanycyte (Mmus)", "taxa": []}
{"type": "biolink:Cell", "ic": 90.871710685482, "identifiers": [{"i": "CL:0008041", "l": "mesothelial cell of intestine", "d": ["A mesothelial cell that is part of the intestinal serosa."], "t": []}], "preferred_name": "mesothelial cell of intestine", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1518067", "l": "Lymphocyte with Basophilic Villous Cytoplasm", "d": [], "t": []}, {"i": "NCIT:C36993", "l": "Lymphocyte with Basophilic Villous Cytoplasm", "d": [], "t": []}], "preferred_name": "Lymphocyte with Basophilic Villous Cytoplasm", "taxa": []}
{"type": "biolink:Cell", "ic": 86.30756602822301, "identifiers": [{"i": "CL:0005006", "l": "ionocyte", "d": ["Specialized epithelial cells involved in the maintenance of osmotic homeostasis. They are characterized by abundant mitochondria and ion transporters. In amniotes, they are present in the renal system. In freshwater fish, ionocytes in the skin and gills help maintain osmotic homeostasis by absorbing salt from the external environment."], "t": []}], "preferred_name": "ionocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "CL:1000425", "l": "chromaffin cell of paraganglion", "d": ["A chromaffin cell that is part of the paraganglion."], "t": []}, {"i": "UMLS:C1181540", "l": "Chromaffin cell of paraganglion", "d": [], "t": []}], "preferred_name": "chromaffin cell of paraganglion", "taxa": []}
{"type": "biolink:Cell", "ic": 76.04769967783396, "identifiers": [{"i": "UMLS:C1708870", "l": "Malignant Cytotrophoblastic Cell", "d": [], "t": []}, {"i": "NCIT:C54118", "l": "Malignant Cytotrophoblastic Cell", "d": [], "t": []}], "preferred_name": "Malignant Cytotrophoblastic Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5960180", "l": "Allogeneic Regulatory T-cells TRX103", "d": [], "t": []}, {"i": "NCIT:C207034", "l": "Allogeneic Regulatory T-cells TRX103", "d": ["A preparation of off-the-shelf (OTS), allogeneic CD4+ cells engineered to mimic regulatory type 1 (Tr1) cells, with potential immunomodulating activity. Upon infusion of allogeneic regulatory T-cells TRX103, these cells secrete the immunomodulatory cytokine interleukin-10 (IL-10) and other cytokines upon exposure to donor T-cells, and may additionally stimulate the production of de novo Tr1 cells. This suppresses immune responses and resets the immune system. This may ultimately prevent or reduce graft versus host disease (GvHD). IL-10 plays a key role in controlling inflammation, downregulating immune responses, and inducing immunological tolerance. IL-10 induces both a long-lasting antigen specific T-cell anergy and the differentiation of Tr1 cells."], "t": []}], "preferred_name": "Allogeneic Regulatory T-cells TRX103", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4697023", "l": "CD27+CD62L+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:1373002008", "l": "", "d": [], "t": []}], "preferred_name": "CD27+CD62L+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0682517", "l": "animal cell line", "d": [], "t": []}], "preferred_name": "animal cell line", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1440293", "l": "CD31+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:1372871006", "l": "", "d": [], "t": []}], "preferred_name": "CD31+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C3496154", "l": "Aaq cell group", "d": [], "t": []}], "preferred_name": "Aaq cell group", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4033118", "l": "thoracic ganglion enkephalin neuron", "d": ["A sympathetic neuron that has the soma located in the thoracic ganglion and expresses the marker enkephalin."], "t": []}], "preferred_name": "thoracic ganglion enkephalin neuron", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5555570", "l": "Anti-CD79b CAR T Cells", "d": [], "t": []}, {"i": "NCIT:C179270", "l": "Anti-CD79b CAR T Cells", "d": ["A preparation of T-lymphocytes that have been genetically modified to express a chimeric antigen receptor (CAR) targeting the tumor-associated antigen (TAA) B-cell antigen receptor complex-associated protein beta chain (CD79b; B-cell-specific glycoprotein B29), with potential immunostimulating and antineoplastic activities. Upon administration, anti-CD79b CAR T cells target and bind to CD79b-expressing tumor cells, thereby inducing selective toxicity in CD79b-expressing tumor cells. CD79b, a critical receptor for successful B cell development and part of the B cell receptor (BCR) signaling complex, is widely expressed in certain subtypes of B cell lymphomas."], "t": []}], "preferred_name": "Anti-CD79b CAR T Cells", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1440376", "l": "CDA Cells", "d": [], "t": []}], "preferred_name": "CDA Cells", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0000761", "l": "type 9 cone bipolar cell (sensu Mus)", "d": ["An ON-bipolar neuron found in the retina and having connections with cone photoreceptors cells and neurons in the inner half of the inner plexiform layer. The dendritic tree is wide and the dendritic convergence indicates cone selectivity. The axon terminal is sparsely branched and terminates in sublamina 5 of the inner plexiform layer."], "t": []}], "preferred_name": "type 9 cone bipolar cell (sensu Mus)", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0599229", "l": "cell wall defective microbial form", "d": [], "t": []}], "preferred_name": "cell wall defective microbial form", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5943482", "l": "AFAMITRESGENE", "d": [], "t": []}], "preferred_name": "AFAMITRESGENE", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5924980", "l": "Lymphoblast specimen", "d": [], "t": []}, {"i": "SNOMEDCT:142261000146106", "l": "", "d": [], "t": []}], "preferred_name": "Lymphoblast specimen", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0011019", "l": "mesothelial cell of epicardium", "d": ["A mesothelial cell that is part of the epicardium."], "t": []}], "preferred_name": "mesothelial cell of epicardium", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1512121", "l": "EG Cell Line", "d": [], "t": []}, {"i": "NCIT:C20231", "l": "EG Cell Line", "d": ["Human EG cells are derived from the primordial germ cells, which occurs in a specific part of the embryo/fetus called the gonadal ridge, and which normally develop into mature gametes (eggs and sperm). Growing pluripotent cells derived from EG cells requires the generation of embryoid bodies, which consist of an unpredictable mix of partially differentially cell types."], "t": []}], "preferred_name": "EG Cell Line", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5180436", "l": "Schistocytes | Blood | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Schistocytes | Blood | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": 90.871710685482, "identifiers": [{"i": "CL:0000533", "l": "primary motor neuron (sensu Teleostei)", "d": ["A primary neuron (sensu Teleostei) that has a motor function."], "t": []}, {"i": "UMLS:C2323550", "l": "Primary motor neuron", "d": [], "t": []}], "preferred_name": "primary motor neuron (sensu Teleostei)", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5446546", "l": "Autologous Anti-CD19 CAR-4-1BB-CD3zeta-expressing T-cells CNCT19", "d": [], "t": []}, {"i": "NCIT:C175465", "l": "Autologous Anti-CD19 CAR-4-1BB-CD3zeta-expressing T-cells CNCT19", "d": ["A preparation of autologous T-lymphocytes that are engineered to express a chimeric antigen receptor (CAR) composed of an anti-cluster of differentiation 19 (CD19) single chain variable fragment (scFv) linked to the intracellular signaling domains of 4-1BB (CD137) and the zeta chain of the TCR/CD3 complex (TCRzeta; CD247; CD3zeta), with potential immunomodulating and antineoplastic activities. Upon administration, the autologous anti-CD19 CAR-4-1BB-CD3zeta-expressing T-cells CNCT19 target, bind to and induce selective toxicity in CD19-expressing tumor cells. CD19 antigen is a B-cell specific cell surface antigen expressed in all B-cell lineage malignancies."], "t": []}], "preferred_name": "Autologous Anti-CD19 CAR-4-1BB-CD3zeta-expressing T-cells CNCT19", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0872268", "l": "self renewing cell", "d": [], "t": []}], "preferred_name": "self renewing cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C4055234", "l": "Circulating Clonotypic B-Cell", "d": [], "t": []}, {"i": "NCIT:C120462", "l": "Circulating Clonotypic B-Cell", "d": ["A B-lymphocyte that is hyperdiploid, has clonotypic IgH gene rearrangements, and is found in the peripheral blood of patients with monoclonal gammopathy of undetermined significance or multiple myeloma."], "t": []}], "preferred_name": "Circulating Clonotypic B-Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4072009", "l": "A12 dopaminergic neuron", "d": ["A type of dopaminergic neuron found in the arcuate hypothalamic nucleus, involved in neuroendocrine regulation, metabolic homeostasis and prolactin secretion."], "t": []}], "preferred_name": "A12 dopaminergic neuron", "taxa": []}
{"type": "biolink:Cell", "ic": 72.11981073685999, "identifiers": [{"i": "CL:4023041", "l": "L5 extratelencephalic projecting glutamatergic cortical neuron", "d": ["A transcriptomically distinct glutamatergic neuron, with a soma found in the deeper portion of L5, that has long-range axonal projections including deep subcortical targets outside of the telencephalon and, in some cases, the spinal cord. While the L5 ET neuron projections are not limited to ET targets, they are clearly differentiated from the neuron subclasses whose projections are constrained to intratelencephalic (IT) targets. L5 ET neurons are generally the largest excitatory cortical neurons, typically having a thick apical dendrite with a prominent dendritic tuft in layer 1 and displaying burst-firing physiological characteristics.", "A transcriptomically distinct glutamatergic neuron, with a soma found in the deeper portion of L5, that has long-range axonal projections including deep subcortical targets outside of the telencephalon and, in some cases, the spinal cord. While the L5 ET neuron projections are not limited to ET targets, they are clearly differentiated from the neuron subclasses whose projections are constrained to intratelencephalic (IT) targets.  L5 ET neurons are generally the largest excitatory cortical neurons, typically having a thick apical dendrite with a prominent dendritic tuft in layer 1 and displaying burst-firing physiological characteristics. The standard transcriptomic reference data for this cell type can be found on the CellxGene census under the collection: 'Transcriptomic cytoarchitecture reveals principles of human neocortex organization', dataset: 'Supercluster: Deep layer (non-IT) excitatory neurons ', Author Categories: 'CrossArea_subclass', clusters L5 ET."], "t": []}], "preferred_name": "L5 extratelencephalic projecting glutamatergic cortical neuron", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5708041", "l": "Anti-GD2/Anti-CD56 4SCAR-expressing Bispecific T-cells", "d": [], "t": []}, {"i": "NCIT:C188801", "l": "Anti-GD2/Anti-CD56 4SCAR-expressing Bispecific T-cells", "d": ["A preparation of T-lymphocytes that are genetically engineered to express a fourth-generation chimeric antigen receptor (4SCAR) targeting the two tumor-associated antigens (TAAs) disialoganglioside (GD2) and CD56 (neural cell adhesion molecule 1; NCAM-1), with potential immunostimulating and antineoplastic activities. Upon administration, the anti-GD2/anti-CD56 4SCAR-expressing bispecific T-cells are directed to and induce selective toxicity in GD2- and CD56-expressing tumor cells. GD2 is overexpressed on the surface of neuroblastoma cells and by other neuroectoderm-derived neoplasms, while it is minimally expressed on normal cells. CD56 is overexpressed on the surface of various types of cancer cells, including small cell lung cancer (SCLC) and other neuroendocrine tumors (NETs)."], "t": []}], "preferred_name": "Anti-GD2/Anti-CD56 4SCAR-expressing Bispecific T-cells", "taxa": []}
{"type": "biolink:Cell", "ic": 92.76600187037766, "identifiers": [{"i": "CL:0002397", "l": "CD14-positive, CD16-positive monocyte", "d": ["A CD14-positive monocyte that is also CD16-positive and CCR2-negative."], "t": []}], "preferred_name": "CD14-positive, CD16-positive monocyte", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5157925", "l": "Cells | Right anterior chamber | NEI eyeGENE slit lamp biomicroscopy", "d": [], "t": []}], "preferred_name": "Cells | Right anterior chamber | NEI eyeGENE slit lamp biomicroscopy", "taxa": []}
{"type": "biolink:Cell", "ic": 48.44971705317964, "identifiers": [{"i": "CL:0000680", "l": "muscle precursor cell", "d": ["A non-terminally differentiated cell that is capable of developing into a muscle cell."], "t": []}], "preferred_name": "muscle precursor cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C4764041", "l": "Autologous Deep IL-15 Primed T-cells TRQ15-01", "d": [], "t": []}, {"i": "NCIT:C158091", "l": "Autologous Deep IL-15 Primed T-cells TRQ15-01", "d": ["A preparation of genetically modified, multi-antigen-directed autologous T-lymphocytes, that have particles, consisting of multiple chemically crosslinked human cytokine interleukin-15 (IL-15)/IL-15 receptor alpha (IL-15Ra)/Fc heterodimers, attached to their surface, with potential immunostimulating and antineoplastic activities. TRQ15-01 is made from monocyte-derived dendritic cells (moDCs) that are pulsed with peptides from multiple tumor-associated antigens (TAAs) to expand cytotoxic T-lymphocytes (CTLs) that are subsequently loaded with IL-15 particles. Upon administration of the autologous deep IL-15 primed T-cells, the IL-15/IL-15Ra fusion proteins are slowly released in vivo from the T-cells in a controlled manner and induce autocrine cytokine stimulation of the administered T-cells, thereby increasing T-cell division of the administered T-cells. The expanded T-cells target, bind to and kill tumor cells. This increases tumor cell growth inhibition by T-cells. IL-15 is a pro-survival, inflammatory cytokine and causes sustained T-cell expansion and enhanced anti-tumor activity. Compared to systemically delivered IL-15, IL-15 attached to the T-cells greatly increases target CD8 T-cell concentrations in the tumor, without significant systemic effects."], "t": []}], "preferred_name": "Autologous Deep IL-15 Primed T-cells TRQ15-01", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5707860", "l": "Vandefitemcel", "d": [], "t": []}, {"i": "NCIT:C188551", "l": "Vandefitemcel", "d": [], "t": []}], "preferred_name": "Vandefitemcel", "taxa": []}
{"type": "biolink:Cell", "ic": 34.70408982844293, "identifiers": [{"i": "CL:0000151", "l": "secretory cell", "d": ["A cell that specializes in controlled release of one or more substances."], "t": []}, {"i": "UMLS:C1519221", "l": "Secretory cell", "d": [], "t": []}, {"i": "NCIT:C13055", "l": "Secretory Cell", "d": ["One of several types of cells that generate and secrete a substance to be used by the organism."], "t": []}], "preferred_name": "secretory cell", "taxa": []}
{"type": "biolink:Cell", "ic": 88.20185721311867, "identifiers": [{"i": "CL:2000030", "l": "hypothalamus cell", "d": ["Any native cell that is part of a hypothalamus."], "t": []}, {"i": "UMLS:C2340547", "l": "Set of dopaminergic cells in anterior area of hypothalamus [A14]", "d": [], "t": []}], "preferred_name": "hypothalamus cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:1000348", "l": "basal cell of epithelium of trachea", "d": ["A basal cell that is part of the epithelium of trachea."], "t": []}, {"i": "UMLS:C2338356", "l": "Basal cell of epithelium of trachea", "d": [], "t": []}], "preferred_name": "basal cell of epithelium of trachea", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1440328", "l": "CD5+CD8+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:1373042003", "l": "", "d": [], "t": []}], "preferred_name": "CD5+CD8+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1522066", "l": "Mouse Basal Cell", "d": [], "t": []}, {"i": "NCIT:C22540", "l": "Mouse Basal Cell", "d": [], "t": []}], "preferred_name": "Mouse Basal Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 60.36955666188042, "identifiers": [{"i": "CL:4023008", "l": "intratelencephalic-projecting glutamatergic cortical neuron", "d": ["A glutamatergic neuron located in the cerebral cortex that projects to structures of telencephalic origins."], "t": []}], "preferred_name": "intratelencephalic-projecting glutamatergic cortical neuron", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C2359880", "l": "Transfuse platelet concentrate", "d": [], "t": []}], "preferred_name": "Transfuse platelet concentrate", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0483186", "l": "CD19+SmIg kappa+", "d": [], "t": []}], "preferred_name": "CD19+SmIg kappa+", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1267874", "l": "Lymphocyte positive for CD15 antigen", "d": [], "t": []}, {"i": "SNOMEDCT:117553009", "l": "", "d": [], "t": []}], "preferred_name": "Lymphocyte positive for CD15 antigen", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5853325", "l": "Autologous Anti-EBV CAR T Cells BRG01", "d": [], "t": []}, {"i": "NCIT:C200907", "l": "Autologous Anti-EBV CAR T Cells BRG01", "d": ["A preparation of autologous T-lymphocytes that are genetically engineered to express a chimeric antigen receptor (CAR) targeting an Epstein-Barr virus (EBV) protein, with potential immunostimulating and antineoplastic activities. Upon intravenous administration, the autologous anti-EBV CAR T cells BRG01 targets a specific EBV protein expressed on EBV-positive cancer cells and promotes killing of these cancer cells. EBV infection is associated with various cancers and the expression of certain EBV specific proteins plays a key role in tumor cell proliferation and survival."], "t": []}], "preferred_name": "Autologous Anti-EBV CAR T Cells BRG01", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0427889", "l": "Vaginal epithelial cell", "d": [], "t": []}, {"i": "SNOMEDCT:91766007", "l": "", "d": [], "t": []}], "preferred_name": "Vaginal epithelial cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0882784", "l": "CD11c+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:116750001", "l": "", "d": [], "t": []}], "preferred_name": "CD11c+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1515968", "l": "Anaplastic Melanocyte", "d": [], "t": []}, {"i": "NCIT:C37110", "l": "Anaplastic Melanocyte", "d": [], "t": []}], "preferred_name": "Anaplastic Melanocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 83.63771255585968, "identifiers": [{"i": "CL:0002603", "l": "astrocyte of the cerebellum", "d": ["An astrocyte of the cerebellum."], "t": []}], "preferred_name": "astrocyte of the cerebellum", "taxa": []}
{"type": "biolink:Cell", "ic": 92.76600187037766, "identifiers": [{"i": "CL:0000757", "l": "type 5 cone bipolar cell (sensu Mus)", "d": ["An ON-bipolar neuron found in the retina and having connections with cone photoreceptors cells and neurons in the inner half of the inner plexiform layer. The axon terminal is restricted to sublamina 3 of the inner plexiform layer. It is narrowly stratified and branched. The dendritic tree has many delicate branches."], "t": []}], "preferred_name": "type 5 cone bipolar cell (sensu Mus)", "taxa": []}
{"type": "biolink:Cell", "ic": 55.40904680371191, "identifiers": [{"i": "CL:0000228", "l": "multinucleate cell", "d": ["A cell with more than one nucleus."], "t": []}], "preferred_name": "multinucleate cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4052003", "l": "intestinal villus capillary endothelial cell", "d": ["A capillary endothelial cell that is part of the intestinal villus. This cell is highly fenestrated, with fenestrations most numerous at the villus tips, and plays a vital role in nutrient absorption and maintaining the selective permeability of the intestinal barrier."], "t": []}], "preferred_name": "intestinal villus capillary endothelial cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0002536", "l": "epithelial cell of amnion", "d": ["An epithelial cell that is part of the amnion."], "t": []}], "preferred_name": "epithelial cell of amnion", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4079014", "l": "lumbar dorsal root ganglion Nav1.9 neuron", "d": ["A nociceptor whose soma is located in the lumbar dorsal root ganglion and that expresses the voltage-gated sodium channel Nav1.9 (encoded by SCN11A). This neuron is characterized by a persistent, tetrodotoxin-resistant sodium current that modulates resting membrane potential and amplifies subthreshold depolarizations, contributing to enhanced excitability during inflammation (Dib-Hajj et al. 2002, PMID:11972962). In human DRG, Nav1.9-immunoreactive neurons constitute approximately 26% of TrkA-positive neurons, a significantly higher proportion than the 12% observed in mouse (Rostock et al. 2018, PMID:29229553), suggesting species differences in inflammatory pain processing."], "t": []}], "preferred_name": "lumbar dorsal root ganglion Nav1.9 neuron", "taxa": []}
{"type": "biolink:Cell", "ic": 83.63771255585968, "identifiers": [{"i": "UMLS:C1514057", "l": "Neoplastic Perineurial Cell", "d": [], "t": []}, {"i": "NCIT:C37154", "l": "Neoplastic Perineurial Cell", "d": [], "t": []}], "preferred_name": "Neoplastic Perineurial Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1514842", "l": "Renal interstitial cell", "d": [], "t": []}, {"i": "NCIT:C33458", "l": "Renal Interstitial Cell", "d": ["A cell of the interstitial tissue of the renal parenchyma. A renal interstitial cell is one of two types. A type I interstitial cell is a fibroblastic cell that is active in the deposition and degradation of the interstitial matrix. It contributes to fibrosis in response to chronic irritation. A type II cell is a macrophage-derived mononuclear cell with phagocytic and immunologic properties. A type II cell is important in antigen presentation. Its cytokines contribute to recruitment of infiltrating cells, progression of injury, and sustenance of fibrogenesis."], "t": []}], "preferred_name": "Renal interstitial cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5853927", "l": "Autologous osteogenic stem cells", "d": [], "t": []}], "preferred_name": "Autologous osteogenic stem cells", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4053624", "l": "lifileucel", "d": [], "t": []}, {"i": "MESH:C000730287", "l": "", "d": [], "t": []}], "preferred_name": "lifileucel", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5401597", "l": "Human Menstrual Blood-derived Stem Cells", "d": [], "t": []}], "preferred_name": "Human Menstrual Blood-derived Stem Cells", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4033153", "l": "jugular ganglion TRPV2 neuron", "d": ["A sensory neuron that has the soma located in the jugular ganglion and expresses the marker transient receptor potential vanilloid 2 (TRPV2)."], "t": []}], "preferred_name": "jugular ganglion TRPV2 neuron", "taxa": []}
{"type": "biolink:Cell", "ic": 87.18682603146104, "identifiers": [{"i": "CL:0011111", "l": "hypothalamic gonadotropin-releasing hormone neuron", "d": ["a specialized neuroendocrine cell that synthesizes and secretes GnRH decapeptide, a key regulator of reproductive function. It originates from the olfactory placode during embryonic development and migrates into the forebrain where it localises predominantly in the hypothalamus and in humans, in extrahypothalamic regions like the basal ganglia (Skrapits et al., 2021). This cell regulates reproduction by secreting GnRH into the pituitary portal vessels to induce the release of gonadotropins into the general circulation. It expresses receptor subunits required for AMPA, NMDA, and kainate receptor signaling and may use glutamate as a neurotransmitter in recurrent collateral innervation."], "t": []}], "preferred_name": "hypothalamic gonadotropin-releasing hormone neuron", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1440294", "l": "CD32+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:1372872004", "l": "", "d": [], "t": []}], "preferred_name": "CD32+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1257858", "l": "COS-7 Cells", "d": [], "t": []}], "preferred_name": "COS-7 Cells", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4522887", "l": "Cells, Cultured, Autologous, Genetically-modified", "d": [], "t": []}], "preferred_name": "Cells, Cultured, Autologous, Genetically-modified", "taxa": []}
{"type": "biolink:Cell", "ic": 82.16838616155795, "identifiers": [{"i": "CL:0000137", "l": "osteocyte", "d": ["A mature osteoblast that has become embedded in the bone matrix. They occupy a small cavity, called lacuna, in the matrix and are connected to adjacent osteocytes via protoplasmic projections called canaliculi."], "t": []}, {"i": "UMLS:C0029432", "l": "Osteocytes", "d": [], "t": []}, {"i": "NCIT:C12569", "l": "Osteocyte", "d": ["A cell that is formed when an osteoblast becomes embedded within the bone matrix that it has secreted. Osteoclasts reside in chambers called lacunae that are found in mature bone."], "t": []}, {"i": "MESH:D010011", "l": "Osteocytes", "d": [], "t": []}, {"i": "SNOMEDCT:23821005", "l": "", "d": [], "t": []}], "preferred_name": "osteocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 92.76600187037766, "identifiers": [{"i": "CL:1001009", "l": "kidney efferent arteriole cell", "d": ["Any kidney arterial blood vessel cell that is part of some renal efferent arteriole."], "t": []}], "preferred_name": "kidney efferent arteriole cell", "taxa": []}
{"type": "biolink:Cell", "ic": 87.18682603146104, "identifiers": [{"i": "UMLS:C1519454", "l": "Spider Cell", "d": [], "t": []}, {"i": "NCIT:C36742", "l": "Spider Cell", "d": [], "t": []}], "preferred_name": "Spider Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 87.18682603146104, "identifiers": [{"i": "UMLS:C1710401", "l": "Thymic Medullary Epithelial Cell", "d": [], "t": []}, {"i": "NCIT:C45702", "l": "Thymic Medullary Epithelial Cell", "d": ["An epithelial cell located in the inner portion of the thymus where the T lymphocytes become mature and are released into the circulation."], "t": []}], "preferred_name": "Thymic Medullary Epithelial Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5853354", "l": "Inaticabtagene Autoleucel", "d": [], "t": []}, {"i": "NCIT:C199061", "l": "Inaticabtagene Autoleucel", "d": [], "t": []}], "preferred_name": "Inaticabtagene Autoleucel", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5166082", "l": "Granulocytes | Dialysis fluid peritoneal | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Granulocytes | Dialysis fluid peritoneal | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": 84.83823963392128, "identifiers": [{"i": "CL:0000682", "l": "M cell of gut", "d": ["An absorptive cell of the gut epithelium that endocytoses microorganisms and intact macromolecules from the gut lumen and transports them to the subepithelial space where they are presented to antigen-presenting cells and lymphocytes."], "t": []}, {"i": "UMLS:C0599757", "l": "M Cells", "d": [], "t": []}, {"i": "MESH:D000092303", "l": "M Cells", "d": [], "t": []}], "preferred_name": "M cell of gut", "taxa": []}
{"type": "biolink:Cell", "ic": 37.99626598326968, "identifiers": [{"i": "CL:0000221", "l": "ectodermal cell", "d": ["A cell of the outer of the three germ layers of the embryo."], "t": []}, {"i": "UMLS:C1183495", "l": "Ectodermal cell", "d": [], "t": []}, {"i": "NCIT:C33935", "l": "Ectoderm Cell", "d": ["An embryonic cell of the outer layer of three germ layers. These cells give rise to the epidermis and neural tissue."], "t": []}], "preferred_name": "ectodermal cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0545579", "l": "Marrow proplasmacyte", "d": [], "t": []}], "preferred_name": "Marrow proplasmacyte", "taxa": []}
{"type": "biolink:Cell", "ic": 89.40238429118027, "identifiers": [{"i": "CL:1001591", "l": "oviduct secretory cell", "d": ["Glandular cell of oviduct epithelium. Example: peg cells, ciliated cells."], "t": []}], "preferred_name": "oviduct secretory cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1267804", "l": "GPA+ lymphocyte", "d": [], "t": []}, {"i": "SNOMEDCT:117508007", "l": "", "d": [], "t": []}], "preferred_name": "GPA+ lymphocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4047045", "l": "type 3 mucosal glia", "d": ["An enteric glial cell located in the lamina propria of the intestinal mucosa. This cell plays important roles in maintaining gut barrier function, regulating intestinal homeostasis, and mediating interactions between the enteric nervous system and the immune system."], "t": []}], "preferred_name": "type 3 mucosal glia", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4239930", "l": "Primitive ectodermal cell", "d": [], "t": []}], "preferred_name": "Primitive ectodermal cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5401596", "l": "Dental Mesenchymal Pulp Stem Cells", "d": [], "t": []}], "preferred_name": "Dental Mesenchymal Pulp Stem Cells", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4033149", "l": "nodose ganglion P2X3 neuron", "d": ["A sensory neuron that has the soma located in the nodose ganglion and expresses the marker purinergic receptor P2X3 (P2X3)."], "t": []}], "preferred_name": "nodose ganglion P2X3 neuron", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4510908", "l": "Blast cell positive for CD135 antigen", "d": [], "t": []}, {"i": "SNOMEDCT:724253008", "l": "", "d": [], "t": []}], "preferred_name": "Blast cell positive for CD135 antigen", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1516958", "l": "Mouse Erythroblast", "d": [], "t": []}, {"i": "NCIT:C22565", "l": "Mouse Erythroblast", "d": [], "t": []}], "preferred_name": "Mouse Erythroblast", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0003018", "l": "retinal ganglion cell B3 inner", "d": ["A retinal ganglion B3 cell with dentrites terminating in S4."], "t": []}], "preferred_name": "retinal ganglion cell B3 inner", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C3178845", "l": "Wharton Jelly Cells", "d": [], "t": []}], "preferred_name": "Wharton Jelly Cells", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4310144", "l": "VTR-HTH Glut glutamatergic neuron of the basal ganglia (Primate)", "d": ["A glutamatergic neuron of the basal ganglia of the Primates brain. These cells are located in the striatum, subthalamic nucleus, substantia nigra . Reference transcriptomic data for this type can be found in the dataset/taxonomy - HMBA Basal Ganglia Consensus Taxonomy in cell set Group:VTR-HTH Glut."], "t": []}], "preferred_name": "VTR-HTH Glut glutamatergic neuron of the basal ganglia (Primate)", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5707721", "l": "Anti-CEA CAR T Cells", "d": [], "t": []}, {"i": "NCIT:C188356", "l": "Anti-CEA CAR T Cells", "d": ["A preparation of T-lymphocytes engineered to express a chimeric antigen receptor (CAR) specific for the tumor-associated antigen (TAA) human carcinoembryonic antigen (CEA), with potential immunostimulating and antineoplastic activities. Upon administration, anti-CEA CAR T cells specifically recognize and induce selective toxicity in CEA-expressing tumor cells. CEA, a member of the CEA family of proteins, plays a key role in cell migration, cell invasion and cell adhesion, and is overexpressed by a variety of cancer types."], "t": []}], "preferred_name": "Anti-CEA CAR T Cells", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5446525", "l": "WT1-H/K-HELP-survivin-H/K-HELP-MAGE-A4-H / K-HELP-MUC1-22 Peptide-loaded Autologous Dendritic Cells", "d": [], "t": []}, {"i": "NCIT:C175443", "l": "WT1-H/K-HELP-survivin-H/K-HELP-MAGE-A4-H / K-HELP-MUC1-22 Peptide-loaded Autologous Dendritic Cells", "d": ["A preparation of autologous dendritic cells (DCs) pulsed with helper/killer-hybrid epitope long peptides (H/K-HELP) of Wilms tumor 1 (WT1 H/K-HELP), survivin, melanoma-associated antigen 4 (MAGE-4) and human mucin 1-22 (Muc1-22), with potential immunomodulating and antineoplastic activities. Upon administration of WT1-H/K-HELP-survivin-H/K-HELP-MAGE-A4-H / K-HELP-Muc1-22 peptide-loaded autologous DCs may stimulate the host immune system to mount an anti-tumoral cytotoxic T lymphocyte (CTL), T-helper (Th), and antibody responses against WT1-, survivin-, MAGE-4- and Muc1-22-expressing cancer cells, resulting in tumor cell lysis. WT1, survivin, MAGE-4 and Muc-1-22, tumor-associated antigens (TAAs), are overexpressed on a variety of cancer cells. The DCs loaded with the long fusion polypeptides, comprising of one or more helper epitopes and killer epitopes, may enhance antigen-specific CTL and Th cell production more efficiently than when the DCs are loaded with a mixture of helper epitope and killer epitope."], "t": []}], "preferred_name": "WT1-H/K-HELP-survivin-H/K-HELP-MAGE-A4-H / K-HELP-MUC1-22 Peptide-loaded Autologous Dendritic Cells", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0427534", "l": "Agranular white blood cell", "d": [], "t": []}, {"i": "SNOMEDCT:250293008", "l": "", "d": [], "t": []}], "preferred_name": "Agranular white blood cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1520131", "l": "Well Differentiated Adenocarcinoma Cell", "d": [], "t": []}, {"i": "NCIT:C36796", "l": "Well Differentiated Adenocarcinoma Cell", "d": [], "t": []}], "preferred_name": "Well Differentiated Adenocarcinoma Cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1171346", "l": "Human Embryonic Stem Cells", "d": [], "t": []}, {"i": "MESH:D000066449", "l": "Human Embryonic Stem Cells", "d": [], "t": []}], "preferred_name": "Human Embryonic Stem Cells", "taxa": []}
{"type": "biolink:Cell", "ic": 92.76600187037766, "identifiers": [{"i": "CL:0003040", "l": "M9 retinal ganglion cell", "d": ["A monostratified retinal ganglion cell with large soma and large dendritic field, with medium dendritic arbor, and has dendrites in layers 1 and 5."], "t": []}], "preferred_name": "M9 retinal ganglion cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4306992", "l": "DCO Il22 Gly-Gaba_2 cerebellar neuron (Mmus)", "d": ["A cerebellar neuron of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Il22 (Mmus), Edaradd (Mmus). It is distinguished from other DCO Il22 Gly-Gaba cells by expression of Ppp1r17. It is GABAergic and glycinergic. These cells are located in the Medulla, Cerebellum, brain , in or close to the regions: Paraflocculus, arbor vitae, Dorsal cochlear nucleus . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5172 DCO Il22 Gly-Gaba_2.", "A cerebellar neuron of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Il22 (Mmus), Edaradd (Mmus). It is distinguished from other DCO Il22 Gly-Gaba cells by expression of Ppp1r17. It is GABAergic and glycinergic (inferred from expression of Slc32a1, Hdc, Slc6a5, Gad2, Gad1). These cells are located in the Medulla, Cerebellum, brain , in or close to the regions: Paraflocculus, arbor vitae, Dorsal cochlear nucleus . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5172 DCO Il22 Gly-Gaba_2."], "t": []}], "preferred_name": "DCO Il22 Gly-Gaba_2 cerebellar neuron (Mmus)", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C6063264", "l": "Cycline D1+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:1373084006", "l": "", "d": [], "t": []}], "preferred_name": "Cycline D1+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": 92.76600187037766, "identifiers": [{"i": "UMLS:C1710397", "l": "Thymic Epithelial Cell Capable of Differentiating Towards Both Cortical and Medullary Cell Type", "d": [], "t": []}, {"i": "NCIT:C45704", "l": "Thymic Epithelial Cell Capable of Differentiating Towards Both Cortical and Medullary Cell Type", "d": ["A reticular epithelial cell generated in the thymus that, in optimal conditions, can become either a cortex type of thymus cell that mediates positive selection or a medullary type of thymus cell that mediates negative selection of developing thymocytes."], "t": []}], "preferred_name": "Thymic Epithelial Cell Capable of Differentiating Towards Both Cortical and Medullary Cell Type", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:2000071", "l": "mammary microvascular endothelial cell", "d": ["Any microvascular endothelial cell that is part of a breast."], "t": []}], "preferred_name": "mammary microvascular endothelial cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5157542", "l": "CD4+CD29+ cells | Blood | Cell markers", "d": [], "t": []}], "preferred_name": "CD4+CD29+ cells | Blood | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0009043", "l": "intestinal crypt stem cell of colon", "d": ["An intestinal crypt stem cell that is located in the crypt of Lieberkuhn of colon."], "t": []}], "preferred_name": "intestinal crypt stem cell of colon", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C0949667", "l": "Hurthle Cells", "d": [], "t": []}, {"i": "NCIT:C33925", "l": "Thyroid Gland Oxyphil Cell", "d": ["A large, granular eosinophilic cell derived from thyroid follicular epithelium by accumulation of mitochondria"], "t": []}], "preferred_name": "Hurthle Cells", "taxa": []}
{"type": "biolink:Cell", "ic": 68.05098739918701, "identifiers": [{"i": "UMLS:C1522529", "l": "Islet Cell", "d": [], "t": []}, {"i": "NCIT:C32885", "l": "Islet Cell", "d": ["A pancreatic cell that produces and secretes hormones such as insulin and glucagon."], "t": []}, {"i": "SNOMEDCT:360555004", "l": "", "d": [], "t": []}], "preferred_name": "Islet Cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5761864", "l": "Allogeneic UCB-NK cells", "d": [], "t": []}], "preferred_name": "Allogeneic UCB-NK cells", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0002163", "l": "internal pillar cell of cochlea", "d": ["A rod-shpaed cell that forms a single row adjacent to and supporting the inner hair cells."], "t": []}, {"i": "UMLS:C1184876", "l": "Internal pillar cell of cochlea", "d": [], "t": []}], "preferred_name": "internal pillar cell of cochlea", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1317332", "l": "Dysmorphic erythrocyte", "d": [], "t": []}, {"i": "SNOMEDCT:725993007", "l": "", "d": [], "t": []}], "preferred_name": "Dysmorphic erythrocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 60.30578213078276, "identifiers": [{"i": "UMLS:C1519262", "l": "Serous Adenocarcinoma Cell", "d": [], "t": []}, {"i": "NCIT:C37115", "l": "Serous Adenocarcinoma Cell", "d": [], "t": []}], "preferred_name": "Serous Adenocarcinoma Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 90.871710685482, "identifiers": [{"i": "CL:0000857", "l": "slow muscle myoblast", "d": ["A skeletal muscle myoblast that differentiates into slow muscle fibers."], "t": []}], "preferred_name": "slow muscle myoblast", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0229611", "l": "Tissue neutrophil", "d": [], "t": []}, {"i": "SNOMEDCT:88397004", "l": "", "d": [], "t": []}], "preferred_name": "Tissue neutrophil", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "CL:0011010", "l": "lateral mesodermal cell", "d": ["A cell derived from the mesoderm that is found at the periphery of the embryo."], "t": []}], "preferred_name": "lateral mesodermal cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1513471", "l": "Monolobed Megakaryocyte", "d": [], "t": []}, {"i": "NCIT:C37048", "l": "Monolobed Megakaryocyte", "d": [], "t": []}], "preferred_name": "Monolobed Megakaryocyte", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5216213", "l": "Erythrocytes|NCnc|Pt|Dial fld", "d": [], "t": []}], "preferred_name": "Erythrocytes|NCnc|Pt|Dial fld", "taxa": []}
{"type": "biolink:Cell", "ic": 84.21065366064373, "identifiers": [{"i": "CL:0001022", "l": "CD115-positive monocyte", "d": ["CD115-positive monocyte is a monocyte that is CD115-positive and CD11b-positive."], "t": []}], "preferred_name": "CD115-positive monocyte", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0682641", "l": "phagocytic reticular cell", "d": [], "t": []}], "preferred_name": "phagocytic reticular cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5426720", "l": "Viable CD45 cells", "d": [], "t": []}], "preferred_name": "Viable CD45 cells", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4042879", "l": "Mouse Embryonic Stem Cells", "d": [], "t": []}, {"i": "MESH:D000066450", "l": "Mouse Embryonic Stem Cells", "d": [], "t": []}], "preferred_name": "Mouse Embryonic Stem Cells", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5690231", "l": "Neutrophils | Amniotic fluid | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Neutrophils | Amniotic fluid | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": 87.18682603146104, "identifiers": [{"i": "CL:0000487", "l": "oenocyte", "d": ["A secretory cell of ectodermal origin. This cell may have important functions in fatty acid and hydrocarbon metabolism and is metabolically linked to the fat body and tracheae. This cell is exclusive of arthropods."], "t": []}], "preferred_name": "oenocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5235893", "l": "Bone Marrow-Derived Mononuclear Cells", "d": [], "t": []}, {"i": "NCIT:C164011", "l": "Bone Marrow-Derived Mononuclear Cells", "d": ["A biological sample containing mononuclear cells isolated from the bone marrow of an experimental subject."], "t": []}], "preferred_name": "Bone Marrow-Derived Mononuclear Cells", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1517354", "l": "GE01 cell line", "d": [], "t": []}, {"i": "NCIT:C20256", "l": "GE01", "d": ["Provider: Geron Corporation, Menlo Park, CA. No information from provider. This cell line meets the criteria for the use of human embryonic stem cells by federally funded researchers."], "t": []}], "preferred_name": "GE01 cell line", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5216218", "l": "Erythrocytes|NCnc|Pt|Plr fld", "d": [], "t": []}], "preferred_name": "Erythrocytes|NCnc|Pt|Plr fld", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1831778", "l": "Viagenpumatucel-L", "d": [], "t": []}, {"i": "NCIT:C61073", "l": "Viagenpumatucel-L", "d": ["A proprietary, allogeneic tumor cell vaccine expressing a recombinant secretory form of the heat shock protein gp96 fusion (gp96-Ig) with potential antineoplastic activity. Upon administration of viagenpumatucel-L, the irradiated live tumor cells continuously secrete gp96-Ig along with its chaperoned tumor associated antigens (TAAs) into the blood stream, thereby activating antigen presenting cells, natural killer cells and priming potent cytotoxic T lymphocytes (CTLs) to respond against TAAs on the endogenous tumor cells. Furthermore, this vaccine may induce long-lived memory T cells that could fight recurring cancer cells. gp96-Ig is constructed by replacing the KDEL retention sequence of gp96, normally an endoplasmatic reticulum-resident chaperone peptide, with the Fc portion of mouse and human IgG1."], "t": []}], "preferred_name": "Viagenpumatucel-L", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0002113", "l": "B220-low CD38-negative unswitched memory B cell", "d": ["A B220-low CD38-negative unswitched memory B cell is a CD38-negative unswitched memory B cell that has the phenotype B220-low, CD38-negative, IgD-positive, CD138-negative, and IgG-negative."], "t": []}], "preferred_name": "B220-low CD38-negative unswitched memory B cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5421015", "l": "Rovaleucel", "d": [], "t": []}, {"i": "NCIT:C174916", "l": "Rovaleucel", "d": [], "t": []}], "preferred_name": "Rovaleucel", "taxa": []}
{"type": "biolink:Cell", "ic": 51.241267347362424, "identifiers": [{"i": "CL:0000236", "l": "B cell", "d": ["A lymphocyte of B lineage that is capable of B cell mediated immunity."], "t": []}, {"i": "UMLS:C0004561", "l": "B-Lymphocytes", "d": [], "t": []}, {"i": "NCIT:C12474", "l": "B-Lymphocyte", "d": ["Immunologically important lymphocyte that is not thymus-dependent, is either short-lived and naive or long-lived and of memory phenotype, and resembles the bursa-derived lymphocyte of birds in that it is responsible for the production of immunoglobulins."], "t": []}, {"i": "MESH:D001402", "l": "B-Lymphocytes", "d": [], "t": []}, {"i": "SNOMEDCT:112130006", "l": "", "d": [], "t": []}], "preferred_name": "B cell", "taxa": []}
{"type": "biolink:Cell", "ic": 59.23882289537889, "identifiers": [{"i": "UMLS:C1514081", "l": "Neoplastic Serous Epithelial Cell", "d": [], "t": []}, {"i": "NCIT:C37114", "l": "Neoplastic Serous Epithelial Cell", "d": [], "t": []}], "preferred_name": "Neoplastic Serous Epithelial Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 84.83823963392128, "identifiers": [{"i": "CL:0002305", "l": "epithelial cell of distal tubule", "d": ["An epithelial cell of the distal convoluted tubule of the kidney that helps regulate systemic levels of potassium, sodium, calcium, and pH."], "t": []}, {"i": "UMLS:C1182798", "l": "Epithelial cell of distal tubule", "d": [], "t": []}], "preferred_name": "epithelial cell of distal tubule", "taxa": []}
{"type": "biolink:Cell", "ic": 90.871710685482, "identifiers": [{"i": "CL:4052030", "l": "adventitial fibroblast", "d": ["A fibroblast of the adventitia of a blood vessel. This cell contributes to vascular homeostasis, remodeling, and inflammation by producing extracellular matrix components, cytokines, and growth factors. Adventitial fibroblast can transition into an activated state during injury or disease, marked by increased proliferation, migration, matrix deposition, and contractile protein expression"], "t": []}], "preferred_name": "adventitial fibroblast", "taxa": []}
{"type": "biolink:Cell", "ic": 66.41906832761713, "identifiers": [{"i": "CL:1000449", "l": "epithelial cell of nephron", "d": ["An epithelial cell that is part of the nephron."], "t": []}, {"i": "UMLS:C1182787", "l": "Epithelial cell of nephron", "d": [], "t": []}], "preferred_name": "epithelial cell of nephron", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:1000374", "l": "transitional myocyte of posterior division of left branch of atrioventricular bundle", "d": ["A transitional myocyte that is part of the posterior division of left branch of atrioventricular bundle."], "t": []}, {"i": "UMLS:C2333606", "l": "Transitional myocyte of posterior division of left branch of atrioventricular bundle", "d": [], "t": []}], "preferred_name": "transitional myocyte of posterior division of left branch of atrioventricular bundle", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5855299", "l": "Trovocabtagene Autoleucel", "d": [], "t": []}, {"i": "NCIT:C199019", "l": "Trovocabtagene Autoleucel", "d": [], "t": []}], "preferred_name": "Trovocabtagene Autoleucel", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5786908", "l": "Dual-target CAR-T Cells BGT007", "d": [], "t": []}, {"i": "NCIT:C198216", "l": "Dual-target CAR-T Cells BGT007", "d": ["A preparation of human T-lymphocytes that have been genetically modified to express a chimeric antigen receptor (CAR) specific for two as of yet undisclosed tumor-associated antigens (TAAs), with potential immunostimulating and antineoplastic activities. Upon administration, the dual-target CAR-T cells BGT007 specifically recognize and induce selective toxicity in tumor cells expressing the two TAAs."], "t": []}], "preferred_name": "Dual-target CAR-T Cells BGT007", "taxa": []}
{"type": "biolink:Cell", "ic": 90.871710685482, "identifiers": [{"i": "CL:4030037", "l": "late spermatid", "d": ["A spermatid in a late stage of maturation that has an elongated morphology and is transcriptionally inert when the acrosome is fully developed."], "t": []}], "preferred_name": "late spermatid", "taxa": []}
{"type": "biolink:Cell", "ic": 90.871710685482, "identifiers": [{"i": "CL:1000427", "l": "adrenal cortex chromaffin cell", "d": ["A chromaffin cell that is part of the adrenal cortex."], "t": []}, {"i": "UMLS:C1181967", "l": "Chromaffin cell of adrenal cortex", "d": [], "t": []}], "preferred_name": "adrenal cortex chromaffin cell", "taxa": []}
{"type": "biolink:Cell", "ic": 87.18682603146104, "identifiers": [{"i": "CL:0002262", "l": "endothelial cell of sinusoid", "d": ["An endothelial cell that lines any of the venous cavities through which blood passes in various glands and organs such as the spleen and liver."], "t": []}, {"i": "UMLS:C1179580", "l": "Endothelial cell of sinusoid", "d": [], "t": []}], "preferred_name": "endothelial cell of sinusoid", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5205117", "l": "Cord Blood-derived CMV/AdV/EBV/BKV-specific Cytotoxic T-lymphocytes", "d": [], "t": []}, {"i": "NCIT:C160294", "l": "Cord Blood-derived CMV/AdV/EBV/BKV-specific Cytotoxic T-lymphocytes", "d": ["A population of allogeneic expanded cord blood (CB)-derived cytotoxic T-lymphocytes (CTLs) that are specifically reactive to cytomegalovirus (CMV), Epstein-Barr virus (EBV), adenovirus (AdV), and human polyomavirus type I (BKV), with potential antiviral activity. Infusion of the CB-derived CMV/AdV /EBV/BKV-specific CTLs into CB hematopoietic stem cell transplant (HSCT) recipients may provide virus-specific cellular immunity, thereby preventing the infection or reactivation of certain viral-associated diseases."], "t": []}], "preferred_name": "Cord Blood-derived CMV/AdV/EBV/BKV-specific Cytotoxic T-lymphocytes", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0002604", "l": "hippocampal astrocyte", "d": ["An astrocyte that is part of the hippocampus."], "t": []}], "preferred_name": "hippocampal astrocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0020044", "l": "migratory muscle precursor", "d": ["Muscle precursor cells that delaminate from the dermomyotome after epithelial-to-mesenchymal transition (EMT) and undergo long-range migration while retaining proliferative capacity."], "t": []}], "preferred_name": "migratory muscle precursor", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1631611", "l": "Bone marrow derived somatic stem cell", "d": [], "t": []}, {"i": "SNOMEDCT:420190000", "l": "", "d": [], "t": []}], "preferred_name": "Bone marrow derived somatic stem cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1440265", "l": "CD19+CD23+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:1372977009", "l": "", "d": [], "t": []}], "preferred_name": "CD19+CD23+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5555016", "l": "Autologous Anti-PD-L1-armored Anti-CD22 CAR T Cells", "d": [], "t": []}, {"i": "NCIT:C178409", "l": "Autologous Anti-PD-L1-armored Anti-CD22 CAR T Cells", "d": ["A preparation of autologous T-lymphocytes that have been genetically engineered to express a chimeric antigen receptor (CAR) specific for the human tumor-associated antigen (TAA) CD22 and carrying a single-chain variable fragment (scFv) of a monoclonal antibody targeting the immunosuppressive ligand programmed cell death-1 ligand 1 (PD-L1; cluster of differentiation 274; CD274), with potential immunomodulatory and antineoplastic activities. Upon infusion, the autologous anti-PD-L1-armored anti-CD22 CAR T cells target and bind to CD22-expressing tumor cells, thereby inducing selective toxicity in CD22-expressing tumor cells. The scFv moiety binds to PD-L1, blocking the binding of PD-L1 to its receptor programmed cell death 1 (PD-1; cluster of differentiation 279; CD279), thereby preventing PD-1 activation on T-lymphocytes. This reverses T-cell inactivation caused by PD-1/PD-L1 signaling and enhances the cytotoxic T-lymphocyte (CTL)-mediated anti-tumor immune response against PD-L1-expressing tumor cells. PD-L1 is overexpressed by many human cancer cell types and plays a key role in the downregulation of the immune system and tumor evasion from host immunity. PD-1, found on activated T-cells, negatively regulates T-cell activity; it plays a key role in immune evasion and prevents tumor cell lysis. CD22, a cell surface glycoprotein, is expressed on mature B-cells and on most malignant B-cells."], "t": []}], "preferred_name": "Autologous Anti-PD-L1-armored Anti-CD22 CAR T Cells", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4072011", "l": "A14 dopaminergic neuron", "d": ["A type of dopaminergic neuron located in the periventricular nucleus of the hypothalamus and projecting to the lateral septum and the median eminence. It is contributing to neuroendocrine functions, locomotion and stress regulation."], "t": []}], "preferred_name": "A14 dopaminergic neuron", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0002512", "l": "CD11b-high, CD103-negative, langerin-negative lymph node dendritic cell", "d": ["A langerin-negative lymph node dendritic cell that is CD103-negative and CD11b-high."], "t": []}], "preferred_name": "CD11b-high, CD103-negative, langerin-negative lymph node dendritic cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5440683", "l": "Breyanzi", "d": [], "t": []}], "preferred_name": "Breyanzi", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4047006", "l": "fetal artery endothelial cell", "d": ["An endothelial cell that lines an artery in the fetal circulatory system."], "t": []}], "preferred_name": "fetal artery endothelial cell", "taxa": []}
{"type": "biolink:Cell", "ic": 72.8241867216765, "identifiers": [{"i": "CL:2000004", "l": "pituitary gland cell", "d": ["Any cell that is part of a pituitary gland."], "t": []}], "preferred_name": "pituitary gland cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4763654", "l": "Ex-vivo Expanded Allogeneic gd T-lymphocytes", "d": [], "t": []}], "preferred_name": "Ex-vivo Expanded Allogeneic gd T-lymphocytes", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5205487", "l": "Autologous Anti-CS1 Hinge-optimized CAR-4-1BB-EGFRt-expressing Memory-enriched T-cells", "d": [], "t": []}, {"i": "NCIT:C160711", "l": "Autologous Anti-CS1 Hinge-optimized CAR-4-1BB-EGFRt-expressing Memory-enriched T-cells", "d": ["A preparation of autologous central memory-enriched T-cells (Tcm) that have been transduced with a self-inactivating (SIN) lentiviral vector expressing a hinge-optimized chimeric antigen receptor (CAR) comprised of a CS1 (CD2 subset 1; SLAM family member 7; SLAMF7; CD319; CRACC)-specific single chain variable fragment (scFV), fused to the costimulatory signaling domain of 4-1BB (CD137), and a truncated human epidermal growth factor receptor (huEGFRt), with potential antineoplastic activity. Upon intravenous infusion, anti-CS1-CAR-4-1BB-CD3z-EGFRt-expressing Tcm-enriched T-lymphocytes target and induce selective toxicity in CS-1-expressing tumor cells. Devoid of both ligand binding domains and tyrosine kinase activity, the expressed huEGFRt facilitates both in vivo detection of the administered, transduced T-cells and can promote elimination of those cells through a cetuximab-induced antibody-dependent cellular cytotoxicity (ADCC) response. CS1, a cell surface glycoprotein of the signaling lymphocyte activation molecule (SLAM) receptor family, is highly expressed on certain malignant plasma cells."], "t": []}], "preferred_name": "Autologous Anti-CS1 Hinge-optimized CAR-4-1BB-EGFRt-expressing Memory-enriched T-cells", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0002655", "l": "epithelial cell of stratum spinosum of esophageal epithelium", "d": ["An epithelial cell of stratum spinosum of esophageal epithelium."], "t": []}, {"i": "UMLS:C1182709", "l": "Epithelial cell of stratum spinosum of esophagus", "d": [], "t": []}], "preferred_name": "epithelial cell of stratum spinosum of esophageal epithelium", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1520009", "l": "Virchow Cell", "d": [], "t": []}, {"i": "NCIT:C33876", "l": "Virchow Cell", "d": [], "t": []}], "preferred_name": "Virchow Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "CL:0002533", "l": "immature CD16-positive myeloid dendritic cell", "d": ["An immature CD16-positive myeloid dendritic cell is CD80-low, CD86-low, and MHCII-low."], "t": []}], "preferred_name": "immature CD16-positive myeloid dendritic cell", "taxa": []}
{"type": "biolink:Cell", "ic": 76.78008365410358, "identifiers": [{"i": "UMLS:C1514026", "l": "Neoplastic Monoblast", "d": [], "t": []}, {"i": "NCIT:C37181", "l": "Neoplastic Monoblast", "d": [], "t": []}], "preferred_name": "Neoplastic Monoblast", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1440297", "l": "CD33+HLA-DR+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:1373275001", "l": "", "d": [], "t": []}], "preferred_name": "CD33+HLA-DR+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": 74.64805296934512, "identifiers": [{"i": "CL:4030062", "l": "L4/5 intratelencephalic projecting glutamatergic neuron", "d": ["An intratelencephalic-projecting glutamatergic with a soma located in cortical layer 4/5."], "t": []}], "preferred_name": "L4/5 intratelencephalic projecting glutamatergic neuron", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C2323094", "l": "Melanocyte of skin", "d": [], "t": []}], "preferred_name": "Melanocyte of skin", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1709172", "l": "Neoplastic Epithelioid Fibrohistiocytic Cell", "d": [], "t": []}, {"i": "NCIT:C49080", "l": "Neoplastic Epithelioid Fibrohistiocytic Cell", "d": [], "t": []}], "preferred_name": "Neoplastic Epithelioid Fibrohistiocytic Cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1184137", "l": "Myoepithelial cell of main lactiferous duct", "d": [], "t": []}], "preferred_name": "Myoepithelial cell of main lactiferous duct", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5557404", "l": "Anti-CLDN18.2 CAR T Cells LY011", "d": [], "t": []}, {"i": "NCIT:C181995", "l": "Anti-CLDN18.2 CAR T Cells LY011", "d": ["A preparation of allogeneic T-lymphocytes that have been genetically modified to express a chimeric antigen receptor (CAR) targeting the tumor-associated antigen (TAA) Claudin18.2 (CLDN18.2; A2 isoform of claudin-18), with potential immunostimulating and antineoplastic activities. Upon administration, the anti-CLDN18.2 CAR T-cells LY011 specifically recognize and bind to CLDN18.2-expressing tumor cells. This may result in a specific cytotoxic T-lymphocyte (CTL)-mediated killing of CLDN18.2-expressing tumor cells. CLDN18.2, a tight junction protein and stomach-specific isoform of claudin-18, is overexpressed on a variety of tumor cells, but its expression in healthy tissues is strictly confined to short-lived differentiated epithelial cells of the gastric mucosa."], "t": []}], "preferred_name": "Anti-CLDN18.2 CAR T Cells LY011", "taxa": []}
{"type": "biolink:Cell", "ic": 77.38833137893549, "identifiers": [{"i": "CL:4300031", "l": "OPC-Oligo cell (Mmus)", "d": ["A cell of the Mus musculus brain. Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Class:31 OPC-Oligo."], "t": []}], "preferred_name": "OPC-Oligo cell (Mmus)", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4310118", "l": "STH PVALB-PITX2 Glut glutamatergic neuron of the basal ganglia (Primate)", "d": ["A glutamatergic neuron of the basal ganglia of the Primates brain. These cells are located in the subthalamic nucleus . Reference transcriptomic data for this type can be found in the dataset/taxonomy - HMBA Basal Ganglia Consensus Taxonomy in cell set Group:STH PVALB-PITX2 Glut."], "t": []}], "preferred_name": "STH PVALB-PITX2 Glut glutamatergic neuron of the basal ganglia (Primate)", "taxa": []}
{"type": "biolink:Cell", "ic": 76.22330125402472, "identifiers": [{"i": "CL:0008055", "l": "respiratory tract secretory epithelial cell", "d": ["A secretory epithelial cell of the respiratory tract epithelium.  These cells have an endodermal origin."], "t": []}], "preferred_name": "respiratory tract secretory epithelial cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4030005", "l": "kidney collecting duct beta-intercalated cell", "d": ["A renal beta-intercalated cell that is part of the cortical collecting duct. The medullary collecting duct does not contain the renal beta-intercalated cell type."], "t": []}], "preferred_name": "kidney collecting duct beta-intercalated cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5447330", "l": "iPSC-derived CD16/IL-15RF-expressing CD38-eliminated NK Cells FT538", "d": [], "t": []}, {"i": "NCIT:C176623", "l": "iPSC-derived CD16/IL-15RF-expressing CD38-eliminated NK Cells FT538", "d": ["An allogeneic, off-the-shelf, natural killer (NK) cell product derived from a clonal master induced pluripotent stem cell (iPSC) line, and engineered and CRISPR-edited to express a high-affinity, non-cleavable CD16 (hnCD16) Fc receptor and a recombinant fusion of IL-15 and IL-15 receptor alpha (IL-15RF), and to eliminate CD38 expression, with potential immunostimulatory and antineoplastic activities. Upon administration, iPSC-derived CD16/IL-15RF-expressing CD38-eliminated NK cells FT538 bind to stress-induced ligands on tumor cells, leading to tumor cell lysis and release of tumor neoantigens. Additionally, FT538 NK cells secrete inflammatory cytokines and chemokines, thereby enhancing T-cell activity and recruitment to the tumor site. IL-15RF promotes the survival of NK cells and enhances the cytotoxic effect of the NK cells and the activated anti-tumor T-cells. When used in combination with monoclonal antibodies, the hnCD16 Fc receptor of FT538 binds to the Fc portion of tumor cell-bound monoclonal antibodies, leading to NK cell activation, cytokine secretion and enhanced antibody-dependent cellular cytotoxicity (ADCC). CD16, also known as Fc-gamma receptor III, is normally expressed on the surface of NK cells, neutrophils, monocytes and macrophages, and plays a key role in initiating ADCC. It is often downregulated in certain cancers, thereby inhibiting the anti-tumor immune response. The lack of CD38 in FT538 NK cells prevents NK cell fratricide upon co-administration with a CD38-targeting monoclonal antibody as CD38 is normally expressed on the surface of activated NK cells. This enhances ADCC mediated by CD38-targeting monoclonal antibodies."], "t": []}], "preferred_name": "iPSC-derived CD16/IL-15RF-expressing CD38-eliminated NK Cells FT538", "taxa": []}
{"type": "biolink:Cell", "ic": 70.44381585922123, "identifiers": [{"i": "CL:0000301", "l": "pole cell", "d": ["A primordial germ cell of insects. Such cells form at the posterior pole of the early embryo."], "t": []}], "preferred_name": "pole cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:1000597", "l": "papillary tips cell", "d": ["A cell that is part of a tip of a renal papilla."], "t": []}], "preferred_name": "papillary tips cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5908862", "l": "CD19-CD34tagged Metabolically Programmed CAR T-cells", "d": [], "t": []}, {"i": "NCIT:C202931", "l": "CD19-CD34tagged Metabolically Programmed CAR T-cells", "d": ["A preparation of a subset of T-lymphocytes, that are metabolically enhanced based on selection and purification on CD34 expression and primed to contain T-helper subset 1 and 17 (Th1/17 hybrid cells), that have been genetically modified to express a chimeric antigen receptor (CAR) targeting the tumor-associated antigen (TAA) CD19, with potential immunostimulating and antineoplastic activities. Upon administration, CD19-CD34tagged metabolically programmed CAR T-cells target and bind to CD19-expressing tumor cells, thereby inducing selective toxicity in CD19-expressing tumor cells. CD19 is a B-cell specific cell surface antigen expressed in all B-cell lineage malignancies. These T-cells may show enhanced persistence and effector function as compared to other, non-metabolically enhanced, anti-CD19 CAR T-cells."], "t": []}], "preferred_name": "CD19-CD34tagged Metabolically Programmed CAR T-cells", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1440937", "l": "Lymphocytes.activated T cells", "d": [], "t": []}], "preferred_name": "Lymphocytes.activated T cells", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4052027", "l": "atretic theca cell", "d": ["A theca cell undergoing atresia, characterized by distinct morphological changes including hypertrophy, altered cell shape, and disrupted layered organization. This cell exhibits reduced steroidogenic capacity and changes in surrounding vascularization. The onset of theca cell atresia can vary, occurring at different stages of follicle atresia depending on the phase of folliculogenesis."], "t": []}], "preferred_name": "atretic theca cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5157445", "l": "CD3+CD45+ cells | Blood | Cell markers", "d": [], "t": []}], "preferred_name": "CD3+CD45+ cells | Blood | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5181908", "l": "Stomatocytes | Blood | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Stomatocytes | Blood | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "UMLS:C0427526", "l": "Large granular lymphocyte", "d": [], "t": []}, {"i": "NCIT:C12921", "l": "Large Granular Lymphocyte", "d": ["A population of large-sized lymphocytes found in human peripheral blood with slightly eccentric nuclei and abundant cytoplasmic azurophilic granules. This population of cells can be comprised of normal natural killer (NK) cells."], "t": []}, {"i": "SNOMEDCT:250285008", "l": "", "d": [], "t": []}], "preferred_name": "Large granular lymphocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 84.83823963392128, "identifiers": [{"i": "CL:4023032", "l": "ON retinal ganglion cell", "d": [], "t": []}], "preferred_name": "ON retinal ganglion cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4307092", "l": "COP NN_1 Rgcc committed oligodendrocyte precursor (Mmus)", "d": ["A committed oligodendrocyte precursor of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Gpr17 (Mmus), Bmp4 (Mmus), Zfp36l1 (Mmus). It is distinguished from other COP NN_1 cells by expression of Rgcc, Plpp4. These cells are located in the Isocortex, brain . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5272 COP NN_1."], "t": []}], "preferred_name": "COP NN_1 Rgcc committed oligodendrocyte precursor (Mmus)", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1440415", "l": "Cells.t(8;21)(q22;q22.3)(RUNX1T1,RUNX1)", "d": [], "t": []}], "preferred_name": "Cells.t(8;21)(q22;q22.3)(RUNX1T1,RUNX1)", "taxa": []}
{"type": "biolink:Cell", "ic": 84.21065366064373, "identifiers": [{"i": "CL:4072002", "l": "myelin-forming oligodendrocyte", "d": ["A postmitotic and differentiated oligodendrocyte derived from a oligodendrocyte progenitor cell. A myelin-forming oligodendrocyte begins the expression of myelin genes and actively engages in the myelination process. In mice and humans, it is characterized by the upregulation of the key myelin-associated markers Mbp and Opalin. Additionally, Ctps (CTP synthase) shows peak expression at this stage, suggesting a heightened demand for nucleotide biosynthesis during membrane expansion and myelin production."], "t": []}], "preferred_name": "myelin-forming oligodendrocyte", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1276860", "l": "Entire granular polyhedral cells of breast", "d": [], "t": []}, {"i": "SNOMEDCT:205384000", "l": "", "d": [], "t": []}], "preferred_name": "Entire granular polyhedral cells of breast", "taxa": []}
{"type": "biolink:Cell", "ic": 90.871710685482, "identifiers": [{"i": "CL:1001502", "l": "mitral cell", "d": ["The large glutaminergic nerve cells whose dendrites synapse with axons of the olfactory receptor neurons in the glomerular layer of the olfactory bulb, and whose axons pass centrally in the olfactory tract to the olfactory cortex."], "t": []}], "preferred_name": "mitral cell", "taxa": []}
{"type": "biolink:Cell", "ic": 85.53200374075534, "identifiers": [{"i": "CL:0000613", "l": "basophil progenitor cell", "d": ["A progenitor cell committed to the basophil lineage. This cell lacks hematopoietic lineage markers (lin-negative) and is CD34-positive, T1/ST2-low, CD117-negative, and FceRIa-high. This cell also expresses Gata-1, Gata-2 and C/EBPa."], "t": []}], "preferred_name": "basophil progenitor cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C0677856", "l": "autologous lymphocytes", "d": [], "t": []}, {"i": "NCIT:C12939", "l": "Autologous Lymphocyte", "d": [], "t": []}], "preferred_name": "autologous lymphocytes", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0000495", "l": "blue sensitive photoreceptor cell", "d": ["A photoreceptor cell that is sensitive to blue light."], "t": []}], "preferred_name": "blue sensitive photoreceptor cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1513816", "l": "NC03", "d": [], "t": []}, {"i": "NCIT:C20283", "l": "NC03", "d": ["Provider: National Centre for Biological Sciences/ Tata Institute of Fundamental Research, Bangalore, India. No information from provider. This cell line meets the criteria for the use of human embryonic stem cells by federally funded researchers."], "t": []}], "preferred_name": "NC03", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4047003", "l": "cycling plasma cell", "d": ["A(n) plasma cell that is cycling."], "t": []}], "preferred_name": "cycling plasma cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5174623", "l": "Neutrophils | Prostatic fluid | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Neutrophils | Prostatic fluid | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5853757", "l": "Lomicel-B", "d": [], "t": []}], "preferred_name": "Lomicel-B", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1440278", "l": "CD29+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:1372869006", "l": "", "d": [], "t": []}], "preferred_name": "CD29+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": 50.68470145208779, "identifiers": [{"i": "CL:0000763", "l": "myeloid cell", "d": ["A cell of the monocyte, granulocyte, mast cell, megakaryocyte, or erythroid lineage."], "t": []}, {"i": "UMLS:C0887899", "l": "Myeloid Cells", "d": [], "t": []}, {"i": "NCIT:C12549", "l": "Myeloid Cell", "d": ["Cells which include the monocytes and the granulocytes."], "t": []}, {"i": "MESH:D022423", "l": "Myeloid Cells", "d": [], "t": []}], "preferred_name": "myeloid cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0333817", "l": "Hyposegmented leukocyte", "d": [], "t": []}, {"i": "SNOMEDCT:42997003", "l": "", "d": [], "t": []}], "preferred_name": "Hyposegmented leukocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C3640100", "l": "Lentivirus Vector rHIV7-shI-TAR-CCR5RZ-transduced Hematopoietic Progenitor Cells", "d": [], "t": []}, {"i": "NCIT:C101371", "l": "Lentivirus Vector rHIV7-shI-TAR-CCR5RZ-transduced Hematopoietic Progenitor Cells", "d": ["Autologous, CD34-positive hematopoietic progenitor cells (HPCs) transduced with rHIV7-shI-TAR-CCR5RZ, a lentiviral vector encoding three anti-human immunodeficiency virus (HIV) RNA genes, with potential antineoplastic activity. The 3 RNA products produced by the lentilvirus are: a short hairpin RNA (shRNA) targeted to an exon of the HIV-1 genes tat/rev, designated as shI; a decoy for the HIV TAT reactive element, designated as TAR; a ribozyme targeting the host cells CCR5 chemokine receptor, designated as CCR5RZ. Upon administration, lentivirus vector rHIV7-shI-TAR-CCR5RZ-transduced hematopoietic progenitor cells expressing the 3 species of RNAs display 3 seperate mechanims of action: the shRNA blocks the transcription of tat/rev, the TAR decoy binds to the TAT protein that is essential for HIV replication, and CCR5RZ catalyzes CCR5 which is needed for viral attachment and entry into the host cells. Altogether, infusion of these HPCs may ultimately inhibit HIV replication and suppress HIV infection."], "t": []}], "preferred_name": "Lentivirus Vector rHIV7-shI-TAR-CCR5RZ-transduced Hematopoietic Progenitor Cells", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4033080", "l": "cycling pulmonary alveolar type 2 cell", "d": ["A(n) pulmonary alveolar type 2 cell that is cycling."], "t": []}], "preferred_name": "cycling pulmonary alveolar type 2 cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0043036", "l": "Warthin-Finkeldey giant cell", "d": [], "t": []}, {"i": "SNOMEDCT:54943009", "l": "", "d": [], "t": []}], "preferred_name": "Warthin-Finkeldey giant cell", "taxa": []}
{"type": "biolink:Cell", "ic": 62.96770704244953, "identifiers": [{"i": "CL:0000126", "l": "macroglial cell", "d": ["A neuroglial cell of ectodermal origin, i.e., the astrocytes and oligodendrocytes considered together."], "t": []}, {"i": "UMLS:C2336790", "l": "Macroglial cell", "d": [], "t": []}], "preferred_name": "macroglial cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C3496271", "l": "B9 serotonin cells", "d": [], "t": []}], "preferred_name": "B9 serotonin cells", "taxa": []}
{"type": "biolink:Cell", "ic": 50.69206685426843, "identifiers": [{"i": "CL:2000032", "l": "peripheral nervous system neuron", "d": ["A neuron that is part of a peripheral nervous system."], "t": []}, {"i": "UMLS:C0682700", "l": "Peripheral neuron", "d": [], "t": []}], "preferred_name": "peripheral nervous system neuron", "taxa": []}
{"type": "biolink:Cell", "ic": 90.871710685482, "identifiers": [{"i": "CL:0008016", "l": "activated skeletal muscle satellite cell", "d": ["A skeletal muscle satellite cell that has become mitotically active - typically following muscle damage."], "t": []}], "preferred_name": "activated skeletal muscle satellite cell", "taxa": []}
{"type": "biolink:Cell", "ic": 75.08236434612573, "identifiers": [{"i": "CL:0000168", "l": "insulin secreting cell", "d": ["Any secretory cell that is capable of some insulin secretion."], "t": []}, {"i": "UMLS:C0030281", "l": "Structure of beta Cell of islet", "d": [], "t": []}, {"i": "NCIT:C32199", "l": "Beta Cell", "d": ["A cell that composes the bulk of the islets of Langerhans and secretes insulin."], "t": []}, {"i": "MESH:D050417", "l": "Insulin-Secreting Cells", "d": [], "t": []}, {"i": "SNOMEDCT:36565008", "l": "", "d": [], "t": []}], "preferred_name": "insulin secreting cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5238924", "l": "Circulating Cancer-Associated Fibroblast", "d": [], "t": []}, {"i": "NCIT:C168535", "l": "Circulating Cancer-Associated Fibroblast", "d": ["A fibroblast found in the peripheral blood that is associated with a neoplastic disease and may colocalize with circulating tumor cells."], "t": []}], "preferred_name": "Circulating Cancer-Associated Fibroblast", "taxa": []}
{"type": "biolink:Cell", "ic": 48.579429297611405, "identifiers": [{"i": "CL:0000056", "l": "myoblast", "d": ["A cell that is commited to differentiating into a muscle cell.  Embryonic myoblasts develop from the mesoderm. They undergo proliferation, migrate to their various sites, and then differentiate into the appropriate form of myocytes.  Myoblasts also occur as transient populations of cells in muscles undergoing repair."], "t": []}, {"i": "UMLS:C0596995", "l": "Myoblasts", "d": [], "t": []}, {"i": "NCIT:C33151", "l": "Myoblast", "d": ["A muscle cell precursor. It is essential for muscle repair."], "t": []}, {"i": "MESH:D032446", "l": "Myoblasts", "d": [], "t": []}], "preferred_name": "myoblast", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C3900006", "l": "Autologous Anti-CD19CAR-4-1BB-CD3zeta-EGFRt-expressing T Lymphocytes", "d": [], "t": []}, {"i": "NCIT:C116914", "l": "Autologous Anti-CD19CAR-4-1BB-CD3zeta-EGFRt-expressing T Lymphocytes", "d": ["A preparation of genetically modified CD8+ central memory (Tcm) and CD4+ autologous T-lymphocytes (1:1) transduced with a replication incompetent, self-inactivating (SIN) lentiviral vector expressing a chimeric antigen receptor (CAR) containing an anti-CD19 single chain variable fragment (scFv) derived from the murine IgG1 monoclonal antibody (mAb) FMC63, fused to the signaling domain of 4-1BB (CD137), the zeta chain of the TCR/CD3 complex (CD3-zeta), and a truncated form of the human epidermal growth factor receptor (EGFRt), with potential immunostimulating and antineoplastic activities. Upon intravenous administration, autologous anti-CD19CAR-4-1BB-CD3zeta-EGFRt-expressing T lymphocytes are directed to and induce selective toxicity in CD19-expressing tumor cells. CD19 antigen is a B-cell specific cell surface antigen expressed in all B-cell lineage malignancies. Devoid of both ligand binding domains and tyrosine kinase activity, the expressed EGFRt both facilitates in vivo detection of the administered, transduced T-cells and can promote elimination of those cells through a cetuximab-induced antibody dependent cellular cytotoxicity response. The 4-1BB costimulatory signaling domain enhances both proliferation of T-cells and antitumor activity."], "t": []}], "preferred_name": "Autologous Anti-CD19CAR-4-1BB-CD3zeta-EGFRt-expressing T Lymphocytes", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "CL:0008005", "l": "obliquely striated somatic muscle cell", "d": ["A somatic muscle cell that is obliquely striated and mononucleated. Examples include the somatic muscles of nematodes."], "t": []}], "preferred_name": "obliquely striated somatic muscle cell", "taxa": []}
{"type": "biolink:Cell", "ic": 78.05853671694304, "identifiers": [{"i": "CL:0000638", "l": "acidophil cell of pars distalis of adenohypophysis", "d": ["An acidophilic chromophil cell that of the anterior pituitary gland."], "t": []}, {"i": "UMLS:C0229536", "l": "Acidophil cell of pars distalis of adenohypophysis", "d": [], "t": []}, {"i": "SNOMEDCT:54913007", "l": "", "d": [], "t": []}], "preferred_name": "acidophil cell of pars distalis of adenohypophysis", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5427575", "l": "Ganglion cells.right", "d": [], "t": []}], "preferred_name": "Ganglion cells.right", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:1000702", "l": "kidney pelvis smooth muscle cell", "d": ["Any smooth muscle cell that is part of some kidney pelvis smooth muscle."], "t": []}], "preferred_name": "kidney pelvis smooth muscle cell", "taxa": []}
{"type": "biolink:Cell", "ic": 87.18682603146104, "identifiers": [{"i": "CL:1000296", "l": "epithelial cell of urethra", "d": ["An epithelial cell that is part of the urethra."], "t": []}, {"i": "UMLS:C2325384", "l": "Epithelial cell of urethra", "d": [], "t": []}], "preferred_name": "epithelial cell of urethra", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5856191", "l": "IL-10-armed Anti-CD19 CAR-T Cells Meta10-19", "d": [], "t": []}, {"i": "NCIT:C200265", "l": "IL-10-armed Anti-CD19 CAR-T Cells Meta10-19", "d": ["A preparation of T-lymphocytes that have been genetically modified to express a chimeric antigen receptor (CAR) targeting the tumor-associated antigen (TAA) CD19, and armed with the anti-inflammatory cytokine interleukin-10 (IL-10), with potential immunostimulating and antineoplastic activities. Upon administration, IL-10-armed anti-CD19 CAR-T cells Meta10-19 recognize and bind to CD19-expressing tumor cells, thereby inducing selective toxicity in CD19-expressing tumor cells. CD19 antigen is a B-cell specific cell surface antigen overexpressed in B-cell lineage malignancies. IL-10 may stimulate the differentiation and expansion of tumor specific cytotoxic CD8+ T-cells."], "t": []}], "preferred_name": "IL-10-armed Anti-CD19 CAR-T Cells Meta10-19", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:1000471", "l": "myoepithelial cell of secondary lactiferous duct", "d": ["A myoepithelial cell that is part of the secondary lactiferous duct."], "t": []}, {"i": "UMLS:C1184139", "l": "Myoepithelial cell of secondary lactiferous duct", "d": [], "t": []}], "preferred_name": "myoepithelial cell of secondary lactiferous duct", "taxa": []}
{"type": "biolink:Cell", "ic": 77.82747199602274, "identifiers": [{"i": "CL:0000072", "l": "non-branched duct epithelial cell", "d": [], "t": []}], "preferred_name": "non-branched duct epithelial cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5668451", "l": "Autologous BCMA/TACI-targeted Trimeric APRIL-based CAR T Cells", "d": [], "t": []}, {"i": "NCIT:C183542", "l": "Autologous BCMA/TACI-targeted Trimeric APRIL-based CAR T Cells", "d": ["A preparation of autologous T-lymphocytes that are genetically engineered to contain a dual-targeted chimeric antigen receptor (CAR), which includes a trimeric form of the natural protein a proliferation-inducing ligand (APRIL; TNFSF13), that targets the tumor-associated antigens (TAAs) B-cell maturation antigen (BCMA; TNFRSF17) and transmembrane activator and calcium modulator and cyclophilin ligand interactor (TACI; TNFRSF13B), with potential immunomodulating and antineoplastic activities. Upon administration, the autologous BCMA/TACI-targeted trimeric APRIL-based CAR T cells bind to BCMA and TACI expressed on tumor cells and induce selective cytotoxicity in those cells. BCMA and TACI, receptors for both APRIL and B-cell activating factor (BAFF), are members of the tumor necrosis factor receptor superfamily (TNFRSF). They are both found on the surfaces of plasma cells, overexpressed on malignant plasma cells and play key roles in plasma cell proliferation and survival. The incorporation of the trimeric, natural conformation of APRIL into the CAR enhances the binding to BCMA and TACI compared with the monomeric form of APRIL."], "t": []}], "preferred_name": "Autologous BCMA/TACI-targeted Trimeric APRIL-based CAR T Cells", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5216279", "l": "Mononuclear cells|NCnc|Pt|CSF", "d": [], "t": []}], "preferred_name": "Mononuclear cells|NCnc|Pt|CSF", "taxa": []}
{"type": "biolink:Cell", "ic": 78.54651317367835, "identifiers": [{"i": "CL:1000495", "l": "small intestine goblet cell", "d": ["A goblet cell that is part of the small intestine."], "t": []}], "preferred_name": "small intestine goblet cell", "taxa": []}
{"type": "biolink:Cell", "ic": 72.8241867216765, "identifiers": [{"i": "CL:0000020", "l": "spermatogonium", "d": ["An euploid male germ cell of an early stage of spermatogenesis."], "t": []}, {"i": "UMLS:C0037866", "l": "Spermatogonia", "d": [], "t": []}, {"i": "NCIT:C12606", "l": "Spermatogonium", "d": ["An undeveloped male germ cell. Spermatogonia develop into primary spermatocytes."], "t": []}, {"i": "MESH:D013093", "l": "Spermatogonia", "d": [], "t": []}, {"i": "SNOMEDCT:67807008", "l": "", "d": [], "t": []}], "preferred_name": "spermatogonium", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4079036", "l": "thoracic dorsal root ganglion substance P neuron", "d": ["A peptidergic nociceptor whose soma is located in the thoracic dorsal root ganglion and that expresses substance P, an 11-amino-acid neuropeptide cleaved from protachykinin-1 (encoded by TAC1). This small-diameter neuron frequently co-expresses CGRP and belongs to the TrkA-positive peptidergic population. Upon nociceptive activation, it releases substance P both centrally in the spinal cord dorsal horn and peripherally at sensory nerve terminals, mediating neurogenic inflammation through NK1 receptor signalling (Haberberger et al. 2019, PMID:31293388). Substance P-immunoreactive neurons have been consistently identified in human DRG by immunohistochemistry across multiple studies."], "t": []}], "preferred_name": "thoracic dorsal root ganglion substance P neuron", "taxa": []}
{"type": "biolink:Cell", "ic": 89.40238429118027, "identifiers": [{"i": "CL:4301590", "l": "Astro-NT NN_2 astrocyte (Mmus)", "d": ["A astrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Gja1 (Mmus), A330076C08Rik (Mmus), Itih3 (Mmus), Gria2 (Mmus). Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Supertype:1160 Astro-NT NN_2."], "t": []}], "preferred_name": "Astro-NT NN_2 astrocyte (Mmus)", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5155169", "l": "Blasts | Fetus | Blood | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Blasts | Fetus | Blood | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5157284", "l": "CD123 blasts | XXX | Cell markers", "d": [], "t": []}], "preferred_name": "CD123 blasts | XXX | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1135970", "l": "Theca lutein cell", "d": [], "t": []}, {"i": "NCIT:C33761", "l": "Theca Lutein Cell", "d": ["A cell of the corpus luteum that is derived from the inner layer of the sheath surrounding the graafian follicle."], "t": []}], "preferred_name": "Theca lutein cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C3849994", "l": "Ia Inhibitory Interneurons", "d": [], "t": []}], "preferred_name": "Ia Inhibitory Interneurons", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "CL:4042019", "l": "beta1-tanycyte", "d": ["A type of tanycyte located in ventral part of the lateral wall of the third ventricle and in the lateral infundibular recess of the brain. This tanycyte has an elongated morphology with multiple microvilli extending into the median eminence. This type of tanycyte expresses FGF receptors 1 and 2, is in contact with GnRH neurons, and is involved in the release of gonadotropin-releasing hormone (GnRH)."], "t": []}], "preferred_name": "beta1-tanycyte", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1512859", "l": "Intermediate-Sized Neoplastic Germ Cell", "d": [], "t": []}, {"i": "NCIT:C37133", "l": "Intermediate-Sized Neoplastic Germ Cell", "d": [], "t": []}], "preferred_name": "Intermediate-Sized Neoplastic Germ Cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1267968", "l": "Lymphocyte positive for CD74 antigen", "d": [], "t": []}, {"i": "SNOMEDCT:117408005", "l": "", "d": [], "t": []}], "preferred_name": "Lymphocyte positive for CD74 antigen", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1441122", "l": "Purkinje cell cytoplasmic type Tr", "d": [], "t": []}], "preferred_name": "Purkinje cell cytoplasmic type Tr", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1440246", "l": "CD11b+CD56+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:1372961008", "l": "", "d": [], "t": []}], "preferred_name": "CD11b+CD56+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1979639", "l": "Blasts.CD21", "d": [], "t": []}], "preferred_name": "Blasts.CD21", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4322819", "l": "CD198+ T lymphocyte", "d": [], "t": []}], "preferred_name": "CD198+ T lymphocyte", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5216272", "l": "Monocytes|NCnc|Pt|Bld", "d": [], "t": []}], "preferred_name": "Monocytes|NCnc|Pt|Bld", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C4086350", "l": "GD2-CAR-expressing Autologous T-lymphocytes", "d": [], "t": []}, {"i": "NCIT:C123820", "l": "GD2-CAR-expressing Autologous T-lymphocytes", "d": ["Genetically modified, autologous T-lymphocytes transduced with a retroviral vector encoding a 14g2a.zeta chimeric antigen receptor (CAR) directed against the disialoganglioside GD2, with potential immunomodulating and antineoplastic activities. Upon intravenous administration, the activated T-lymphocytes target the GD2 antigen on tumor cells and selectively kill those cells. The tumor-associated antigen GD2 is overexpressed on the surface of almost all tumors of neuroectodermal origin."], "t": []}], "preferred_name": "GD2-CAR-expressing Autologous T-lymphocytes", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C3827138", "l": "Autologous CT7/MAGE-A3/WT1 mRNA-Electroporated Langerhans-Type Dendritic Cells", "d": [], "t": []}, {"i": "NCIT:C113174", "l": "Autologous CT7/MAGE-A3/WT1 mRNA-Electroporated Langerhans-Type Dendritic Cells", "d": ["An autologous tumor cell vaccine containing CD34+ hematopoietic progenitor cell (HPC)-derived Langerhans-type dendritic cells (LCs) electroporated with mRNA encoding the full-length cancer-testis antigens, CT7 and melanoma-associated antigen 3 (MAGE-A3), and the self-differentiation tumor antigen, Wilms tumor 1 (WT1) with potential immunomodulating and antineoplastic activity. The autologous CT7/MAGE-A3/WT1 mRNA-electroporated Langerhans-type dendritic cells are prepared by drawing a blood sample containing the CD34+ HPCs from a cancer patient. The CD34+ HPCs are treated with a combination of cytokines which specifically support LC development, and the LC population is enriched and expanded ex vivo. The cultured LCs are allowed to mature for one day and then electroporated separately with CT7, MAGE-A3 or WT1 mRNA before final maturation. Upon intradermal administration into the patient, the mature LCs may activate cell-mediated immunity and induce both cytotoxic CD8+ T cells and CD4+ helper T cells against cancer cells expressing CT7, MAGE-A3 and WT1 tumor antigens. This may result in the immune-mediated inhibition of tumor cell proliferation, leading to tumor cell death. CT7 and MAGE-A3 are tumor-specific proteins overexpressed in a number of cancers but not in healthy tissues other than testis and placenta. WT1 is a transcription factor important in development and cancer pathogenesis, which is overexpressed in a variety of cancers, including multiple myeloma, leukemia, ovarian cancer, malignant mesothelioma, neural tumors and renal carcinoma."], "t": []}], "preferred_name": "Autologous CT7/MAGE-A3/WT1 mRNA-Electroporated Langerhans-Type Dendritic Cells", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C3900002", "l": "Autologous CD8+ Melanoma Specific T Cells", "d": [], "t": []}, {"i": "NCIT:C116072", "l": "Autologous CD8+ Melanoma Specific T Cells", "d": ["Autologous CD8 T-lymphocytes against melanoma-associated antigens, with potential immunomodulating and antineoplastic activities. Following leukapheresis and the ex vivo expansion of cytotoxic T-lymphocytes, the autologous CD8+ melanoma specific T-cells are re-introduced into the melanoma patient. These cytotoxic T-cells recognize and kill the patient's own melanoma cells."], "t": []}], "preferred_name": "Autologous CD8+ Melanoma Specific T Cells", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0020013", "l": "dermal sheath fibroblast", "d": ["A fibroblast forming the connective tissue sheath that encloses the hair follicle epithelium from the level of the bulge downward to the hair bulb. This cell expresses characteristic markers, including DPEP1 in humans and COL11A1 and ACTA2 (alpha-smooth muscle actin) in mice and humans. Dermal sheath fibroblast possesses contractile properties mediated by calcium-calmodulin-myosin light chain kinase signalling, generating centripetal force during hair follicle catagen that relocates the dermal papilla to the stem cell niche."], "t": []}], "preferred_name": "dermal sheath fibroblast", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C4725828", "l": "Allogeneic Most Closely HLA-matched Adenovirus-specific Cytotoxic T Lymphocytes", "d": [], "t": []}, {"i": "NCIT:C150553", "l": "Allogeneic Most Closely HLA-matched Adenovirus-specific Cytotoxic T Lymphocytes", "d": ["A population of off the shelf, closely human leukocyte antigen (HLA)-matched allogeneic, ex vivo-expanded cytotoxic T-lymphocytes (CTLs) specifically reactive to human adenovirus (Ad), with potential immunomodulating and anti-adenoviral activities. Upon administration, the allogeneic most closely HLA-matched Ad-specific CTLs may reconstitute Ad-specific CTL responses in patients at risk of developing Ad infections either following allogeneic stem cell transplantation or in Ad-infected immunocompromised hosts. The anti-adenoviral CTLs are provided by a third party donor and not by the allogeneic stem cell transplant donor."], "t": []}], "preferred_name": "Allogeneic Most Closely HLA-matched Adenovirus-specific Cytotoxic T Lymphocytes", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5157622", "l": "CD57 cells | Blood | Cell markers", "d": [], "t": []}], "preferred_name": "CD57 cells | Blood | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5417766", "l": "Temferon", "d": [], "t": []}], "preferred_name": "Temferon", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0000901", "l": "Tr1 cell", "d": ["CD4-positive alpha-beta T cell with regulatory function that produces IL-10."], "t": []}], "preferred_name": "Tr1 cell", "taxa": []}
{"type": "biolink:Cell", "ic": 48.33537896725613, "identifiers": [{"i": "UMLS:C1513026", "l": "Mature Lymphocyte", "d": [], "t": []}, {"i": "NCIT:C38439", "l": "Mature Lymphocyte", "d": ["A white blood cell that matures in the primary lymphoid organs and then circulates through the lymph system to the secondary lymphoid tissues where it interacts with antigens. A mature lymphocyte varies in size from 7 to 15 micrometer in diameter and is round or ovoid, but may be notched or slightly indented. The chromatin is generally diffusely dense and nucleoli are not usually visible."], "t": []}], "preferred_name": "Mature Lymphocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1518019", "l": "Low Grade Malignant Transitional Cell", "d": [], "t": []}, {"i": "NCIT:C36839", "l": "Low Grade Malignant Transitional Cell", "d": [], "t": []}], "preferred_name": "Low Grade Malignant Transitional Cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C2340307", "l": "Pterygopalatine ganglion neuron", "d": [], "t": []}], "preferred_name": "Pterygopalatine ganglion neuron", "taxa": []}
{"type": "biolink:Cell", "ic": 92.76600187037766, "identifiers": [{"i": "CL:4030026", "l": "BEST4+ enterocyte", "d": ["An enterocyte of the human intestine expressing bestrophin-4 (BEST4) calcium-activated ion channels."], "t": []}], "preferred_name": "BEST4+ enterocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:1000357", "l": "microfold cell of epithelium proper of jejunum", "d": ["A M cell that is part of the epithelium proper of jejunum."], "t": []}, {"i": "UMLS:C2333238", "l": "Microfold cell of epithelium proper of jejunum", "d": [], "t": []}], "preferred_name": "microfold cell of epithelium proper of jejunum", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C2930253", "l": "Carticel", "d": [], "t": []}], "preferred_name": "Carticel", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4040005", "l": "mesenchymal stem cell of apical papilla", "d": ["A mesenchymal stem cell that is part of the apical papilla tooth root."], "t": []}], "preferred_name": "mesenchymal stem cell of apical papilla", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4510885", "l": "Blast cell positive for CD13 antigen", "d": [], "t": []}, {"i": "SNOMEDCT:724270000", "l": "", "d": [], "t": []}], "preferred_name": "Blast cell positive for CD13 antigen", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5170956", "l": "Leukocytes other | Peritoneal fluid | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Leukocytes other | Peritoneal fluid | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5163543", "l": "Epithelial cells | Urine sediment | Urinalysis", "d": [], "t": []}], "preferred_name": "Epithelial cells | Urine sediment | Urinalysis", "taxa": []}
{"type": "biolink:Cell", "ic": 75.876659701315, "identifiers": [{"i": "CL:0000169", "l": "type B pancreatic cell", "d": ["A cell that secretes insulin and is located towards the center of the islets of Langerhans."], "t": []}], "preferred_name": "type B pancreatic cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0000983", "l": "IgM plasmablast", "d": ["A plasmablast that secretes IgM."], "t": []}], "preferred_name": "IgM plasmablast", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0682548", "l": "Amphophilic cell", "d": [], "t": []}], "preferred_name": "Amphophilic cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5219210", "l": "Neutrophils|NCnc|Urine", "d": [], "t": []}], "preferred_name": "Neutrophils|NCnc|Urine", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C4525936", "l": "Neural Stem Cells-expressing CRAd-S-pk7", "d": [], "t": []}, {"i": "NCIT:C135612", "l": "Neural Stem Cells-expressing CRAd-S-pk7", "d": ["Neural stem cells (NSCs) that are transfected with the gliomatropic oncolytic adenovirus (OV) CRAd-S-pk7, a conditionally replicative oncolytic adenoviral (CRAd) vector that contains the tumor-specific survivin promoter (S) and a fiber protein polylysine modification (pk7), with potential antineoplastic activity. Upon intracerebral administration of NSC loaded with CRAd-S-pk7, the NSCs preferentially migrate towards tumor cells, and the polylysine moiety of the modified fiber protein expressed by the viral vector specifically targets and binds to tumor-specific heparan sulfate proteoglycans. Subsequently, the virus can infect the tumor cells and viral replication is initiated because E1 gene expression is controlled by the tumor-specific promoter for survivin. This results in the specific lysis of the glioma cells. The pk7 fiber modification and the survivin promoter enable tumor-specific infectivity, and transcriptional targeting and preferential replication in glioma cells, while sparing the surrounding normal brain parenchyma. The pK7 is comprised of a heparan sulfate binding domain incorporated into the fiber protein of the adenovirus."], "t": []}], "preferred_name": "Neural Stem Cells-expressing CRAd-S-pk7", "taxa": []}
{"type": "biolink:Cell", "ic": 86.30756602822301, "identifiers": [{"i": "CL:4023086", "l": "T Martinotti neuron", "d": ["A Martinotti neuron that has axons that form a horizontal ramification, making it T-shaped."], "t": []}], "preferred_name": "T Martinotti neuron", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5834091", "l": "Strimvelis", "d": [], "t": []}], "preferred_name": "Strimvelis", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4697058", "l": "Predominant leukocyte", "d": [], "t": []}], "preferred_name": "Predominant leukocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "CL:0013000", "l": "forebrain radial glial cell", "d": ["Any radial glial cell that is part of some forebrain."], "t": []}], "preferred_name": "forebrain radial glial cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0001087", "l": "effector memory CD4-positive, alpha-beta T cell, terminally differentiated", "d": ["A CD4-positive, alpha beta memory T cell with the phenotype CD45RA-positive, CD45RO-negative, and CCR7-negative."], "t": []}], "preferred_name": "effector memory CD4-positive, alpha-beta T cell, terminally differentiated", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C4524459", "l": "Autologous EGFRt/19-28z/4-1BBL CAR T-Lymphocytes", "d": [], "t": []}, {"i": "NCIT:C133189", "l": "Autologous EGFRt/19-28z/4-1BBL CAR T-Lymphocytes", "d": ["Genetically modified autologous T-lymphocytes transduced with a replication incompetent retroviral vector expressing both tumor necrosis factor ligand superfamily (TNFSF) member 9 (TNFSF9; 4-1BBL) and a chimeric T cell antigen receptor (CAR) consisting of an anti-CD19 scFv (single chain variable fragment), fused to the extracellular, transmembrane and intracellular signaling domains of the T-cell co-stimulatory receptor CD28, the cytoplasmic signaling domain of the zeta chain of the TCR/CD3 complex (CD3-zeta) (19-28z), and a truncated form of the human epidermal growth factor receptor (EGFRt), with potential immunostimulating and antineoplastic activities. Upon intravenous administration, autologous EGFRt/19-28z/4-1BBL CAR T-lymphocytes are directed to CD19-expressing tumor cells, which induces selective toxicity in CD19-expressing tumor cells. These cells also express 4-1BBL, a secreted protein and member of the TNFSF of growth factors, that induces proliferation of T-cells and may help reverse immunosuppression in the tumor environment. CD19 antigen is a B-cell specific cell surface antigen expressed in all B-cell lineage malignancies. The CD28 co-stimulatory molecule signaling domain enhances activation and signaling after recognition of CD19. The inclusion of the CD28 signaling domain may increase proliferation of T-cells and antitumor activity compared to the inclusion of the CD3-zeta chain alone. Devoid of both ligand binding domains and tyrosine kinase activity, EGFRt both facilitates in vivo detection of the administered, transduced T-cells and can promote elimination of those cells through a cetuximab-induced antibody dependent cellular cytotoxicity (ADCC) response."], "t": []}], "preferred_name": "Autologous EGFRt/19-28z/4-1BBL CAR T-Lymphocytes", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4047056", "l": "large mucus secreting cholangiocyte", "d": ["A columnar, mucin-producing cholangiocyte that lines large bile ducts, including the hilar bile duct, right and left hepatic bile ducts, and large intrahepatic bile ducts. This cell expresses phosphorylated STAT3 and TFF-3 in humans and mice."], "t": []}], "preferred_name": "large mucus secreting cholangiocyte", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5926368", "l": "ALLOGENIC HUMAN PLACENTA MESENCHYMAL STEM CELL-DERIVED EXOSOMES", "d": [], "t": []}], "preferred_name": "ALLOGENIC HUMAN PLACENTA MESENCHYMAL STEM CELL-DERIVED EXOSOMES", "taxa": []}
{"type": "biolink:Cell", "ic": 57.210963867825484, "identifiers": [{"i": "CL:0000515", "l": "skeletal muscle myoblast", "d": ["A myoblast that differentiates into skeletal muscle fibers."], "t": []}, {"i": "UMLS:C1135922", "l": "Myoblasts, Skeletal", "d": [], "t": []}, {"i": "MESH:D032448", "l": "Myoblasts, Skeletal", "d": [], "t": []}], "preferred_name": "skeletal muscle myoblast", "taxa": []}
{"type": "biolink:Cell", "ic": 90.871710685482, "identifiers": [{"i": "CL:0000703", "l": "sustentacular cell", "d": ["Cell that provides some or all mechanical, nutritional and phagocytic support to their neighbors."], "t": []}], "preferred_name": "sustentacular cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5179517", "l": "Reticulocytes | Blood | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Reticulocytes | Blood | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4304494", "l": "Population of all stomatocytes in portion of fluid", "d": [], "t": []}, {"i": "SNOMEDCT:719694005", "l": "", "d": [], "t": []}], "preferred_name": "Population of all stomatocytes in portion of fluid", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5157515", "l": "CD3-CD16+ cells | Blood | Cell markers", "d": [], "t": []}], "preferred_name": "CD3-CD16+ cells | Blood | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5180575", "l": "Segmented neutrophils | Body fluid | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Segmented neutrophils | Body fluid | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": 79.07356789860069, "identifiers": [{"i": "CL:0000810", "l": "CD4-positive, alpha-beta thymocyte", "d": ["An immature alpha-beta T cell that is located in the thymus and is CD4-positive and CD8-negative."], "t": []}], "preferred_name": "CD4-positive, alpha-beta thymocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0009049", "l": "smooth muscle cell of high endothelial venule of lymph node", "d": ["A layer of smooth muscle cells that forms the outer layer of the high endothelial venule of lymph node and pumps to allow flow of lymph fluid carrying lymphocytes."], "t": []}], "preferred_name": "smooth muscle cell of high endothelial venule of lymph node", "taxa": []}
{"type": "biolink:Cell", "ic": 88.20185721311867, "identifiers": [{"i": "UMLS:C1514736", "l": "Reactive Epithelial Cell", "d": [], "t": []}, {"i": "NCIT:C36809", "l": "Reactive Epithelial Cell", "d": [], "t": []}], "preferred_name": "Reactive Epithelial Cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1545461", "l": "CD11c+CD19+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:1372963006", "l": "", "d": [], "t": []}], "preferred_name": "CD11c+CD19+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5555879", "l": "ARI-0001", "d": [], "t": []}], "preferred_name": "ARI-0001", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C2986402", "l": "Anti-CTLA4 MoAb RNA-transfected Autologous Dendritic Cell Vaccine", "d": [], "t": []}, {"i": "NCIT:C94217", "l": "Anti-CTLA4 MoAb RNA-transfected Autologous Dendritic Cell Vaccine", "d": ["An autologous dendritic cell (DC) cancer vaccine with potential immunostimulatory activity. Anti-CTLA4 MoAb RNA-transfected autologous DC vaccine is prepared by transfecting DCs with RNAs encoding humanized heavy and light chains of the anti-CTLA4 (cytotoxic T-Lymphocyte-Associated Antigen 4); expression of anti-CTLA4 blocks the inhibitory effect of CTLA4 on the activation of T-lymphocytes. Co-vaccination of this vaccine with melanoma antigen specific vaccine may eliminate the adverse effects associated with systemic administration of immune modulators, while also enhancing vaccine-induced immune responses."], "t": []}], "preferred_name": "Anti-CTLA4 MoAb RNA-transfected Autologous Dendritic Cell Vaccine", "taxa": []}
{"type": "biolink:Cell", "ic": 69.94527858408269, "identifiers": [{"i": "CL:0000120", "l": "granule cell", "d": ["A neuron of the vertebrate central nervous system that is small in size. This general class includes small neurons in the granular layer of the cerebellar cortex, cerebral cortex neurons that are not pyramidal cells and small neurons without axons found in the olfactory bulb."], "t": []}], "preferred_name": "granule cell", "taxa": []}
{"type": "biolink:Cell", "ic": 85.53200374075534, "identifiers": [{"i": "UMLS:C5856644", "l": "Anti-PSMA CAR T Cells Preparation", "d": [], "t": []}, {"i": "NCIT:C201178", "l": "Anti-PSMA CAR T Cells Preparation", "d": ["Any preparation of chimeric antigen receptor (CAR) expressing T-lymphocytes that targets the tumor-associated antigen (TAA) prostate-specific membrane antigen (PSMA)."], "t": []}], "preferred_name": "Anti-PSMA CAR T Cells Preparation", "taxa": []}
{"type": "biolink:Cell", "ic": 79.9528279018387, "identifiers": [{"i": "CL:0002433", "l": "CD69-positive, CD4-positive single-positive thymocyte", "d": ["A CD4-positive, CD8-negative thymocyte that expresses high levels of the alpha-beta T cell receptor and is CD69-positive."], "t": []}], "preferred_name": "CD69-positive, CD4-positive single-positive thymocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 84.83823963392128, "identifiers": [{"i": "CL:0000583", "l": "alveolar macrophage", "d": ["A tissue-resident macrophage found in the alveoli of the lungs. Ingests small inhaled particles resulting in degradation and presentation of the antigen to immunocompetent cells. Markers include F4/80-positive, CD11b-/low, CD11c-positive, CD68-positive, sialoadhesin-positive, dectin-1-positive, MR-positive, CX3CR1-negative."], "t": []}, {"i": "UMLS:C0085236", "l": "Macrophages, Alveolar", "d": [], "t": []}, {"i": "NCIT:C12565", "l": "Alveolar Macrophage", "d": ["Phagocytic macrophages on the surface of the pulmonary alveoli.  They ingest foreign substances inhaled into the alveoli."], "t": []}, {"i": "MESH:D016676", "l": "Macrophages, Alveolar", "d": [], "t": []}, {"i": "SNOMEDCT:33956004", "l": "", "d": [], "t": []}], "preferred_name": "alveolar macrophage", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1516094", "l": "Atypical Epithelioid Cell", "d": [], "t": []}, {"i": "NCIT:C37118", "l": "Atypical Epithelioid Cell", "d": [], "t": []}], "preferred_name": "Atypical Epithelioid Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5555145", "l": "Allogeneic Anti-CD5-IL-15/IL-15sushi-safety Switch CAR T Cells", "d": [], "t": []}, {"i": "NCIT:C178587", "l": "Allogeneic Anti-CD5-IL-15/IL-15sushi-safety Switch CAR T Cells", "d": ["A preparation of allogeneic T-lymphocytes that have been transduced with a lentiviral vector to express a chimeric antigen receptor (CAR) consisting of a humanized anti-CD5 single chain variable fragment (scFv) domain linked to a interleukin (IL)-15/IL-15sushi domain and a safety switch, with potential immunostimulating and antineoplastic activities. Upon administration, the allogeneic anti-CD5-IL-15/IL-15sushi-safety switch CAR T cells target and bind to CD5-expressing tumor cells, thereby inducing selective cytotoxicity in CD5-expressing tumor cells. The IL-15/IL-15sushi domain activates and increases the levels of natural killer (NK) cells and memory CD8+ T-cells. The memory T-cells enhance the secretion of the cytokine interferon-gamma (IFN-g), which further potentiates the immune response against tumor cells. This may increase tumor cell killing and decrease tumor cell proliferation. The pro-survival cytokine IL-15 regulates CD8+ T and NK cell development, activation and proliferation. The safety switch, composed of two rituximab (RTX)-binding epitope sites, allows for the selective elimination of the CAR-T cells through the administration of RTX. CD5, a T-cell associated antigen, is expressed in many T-cell lymphomas and leukemias."], "t": []}], "preferred_name": "Allogeneic Anti-CD5-IL-15/IL-15sushi-safety Switch CAR T Cells", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5383249", "l": "Leukocytes | Stem cell product | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Leukocytes | Stem cell product | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C6065177", "l": "CTA30X UCAR-T", "d": [], "t": []}], "preferred_name": "CTA30X UCAR-T", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0009085", "l": "colony forming unit – Hill cell", "d": ["An adult endothelial progenitor cell characterised in vivo by homing to ischemic sites and paracrine support of angiogenesis. They may form discrete colonies."], "t": []}], "preferred_name": "colony forming unit – Hill cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1622423", "l": "polymorphonuclear granulocyte", "d": [], "t": []}], "preferred_name": "polymorphonuclear granulocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "CL:0000716", "l": "lymph gland crystal cell", "d": ["A crystal cell that derives from the larval lymph gland."], "t": []}], "preferred_name": "lymph gland crystal cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5174618", "l": "Neutrophils | Fetus | Pleural fluid | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Neutrophils | Fetus | Pleural fluid | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": 70.15433324931317, "identifiers": [{"i": "CL:0000946", "l": "antibody secreting cell", "d": ["A lymphocyte of B lineage that is devoted to secreting large amounts of immunoglobulin."], "t": []}], "preferred_name": "antibody secreting cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5575457", "l": "Autologous Anti-CD7-CAR-CD28zeta T-cells", "d": [], "t": []}, {"i": "NCIT:C185169", "l": "Autologous Anti-CD7-CAR-CD28zeta T-cells", "d": ["A preparation of autologous T-lymphocytes that have been genetically engineered to express a chimeric antigen receptor (CAR) directed against the CD7 antigen and linked to the co-stimulatory domains of CD28 and the zeta chain of the TCR/CD3 complex (CD3-zeta) (CD28zeta), with potential immunostimulating and antineoplastic activities. Upon administration, the autologous anti-CD7-CAR-CD28zeta T-cells specifically recognize and bind to CD7-expressing tumor cells, resulting in specific T-cell-mediated tumor cell lysis. CD7 is a transmembrane glycoprotein expressed by T-cells and natural killer (NK) cells and their precursors. It is expressed in the majority of lymphoblastic T-cell leukemias and lymphomas and in a subset of peripheral T-cell lymphomas."], "t": []}], "preferred_name": "Autologous Anti-CD7-CAR-CD28zeta T-cells", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4307103", "l": "MFOL NN_3 Il23a myelin-forming oligodendrocyte (Mmus)", "d": ["A myelin-forming oligodendrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of 9630013A20Rik (Mmus), Ppp1r14a (Mmus), Mroh3 (Mmus). It is distinguished from other MFOL NN_3 cells by expression of Il23a, Ppp1r14a. These cells are located in the Midbrain, Isocortex, brain . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5283 MFOL NN_3."], "t": []}], "preferred_name": "MFOL NN_3 Il23a myelin-forming oligodendrocyte (Mmus)", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1455886", "l": "Atypical Endocervical Cell", "d": [], "t": []}, {"i": "NCIT:C141518", "l": "Atypical Endocervical Cell", "d": ["An abnormal endocervical cell found in a cervical smear. It may be related to an inflammatory or neoplastic process."], "t": []}], "preferred_name": "Atypical Endocervical Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 71.31251504405601, "identifiers": [{"i": "CL:0002086", "l": "specialized cardiac myocyte", "d": ["A cardiac myocyte that is an excitable cells in the myocardium, specifically in the conducting system of heart."], "t": []}, {"i": "UMLS:C1180383", "l": "Specialized cardiac myocyte", "d": [], "t": []}], "preferred_name": "specialized cardiac myocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 83.11065783093733, "identifiers": [{"i": "CL:0002152", "l": "columnar cell of endocervix", "d": ["A simple columnar epithelial cell located in the endocervix."], "t": []}, {"i": "UMLS:C1516837", "l": "Columnar cell of endocervix", "d": [], "t": []}, {"i": "NCIT:C33914", "l": "Endocervical Columnar Cell", "d": ["A mucus-producing epithelial cell lining the endocervical lumen."], "t": []}], "preferred_name": "columnar cell of endocervix", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C4525410", "l": "Alloantigen-specific Allogeneic Type 1 Regulatory T Cells T-allo10", "d": [], "t": []}, {"i": "NCIT:C134838", "l": "Alloantigen-specific Allogeneic Type 1 Regulatory T Cells T-allo10", "d": ["A preparation of allogeneic CD4+ cells that were ex vivo stimulated with alloantigens, which involves exposing the cells to host antigen-presenting cells (APCs), in the presence of the immunomodulatory cytokine interleukin-10 (IL-10), with potential to prevent graft-versus-host disease (GvHD). The stimulation of the CD4+ cells by exposure to alloantigens plus IL-10 induces the differentiation of alloantigen-specific type 1 T regulatory (TR1) cells, which are hyporesponsive to the alloantigens. Upon infusion of T-allo10 and prior to donor hematopoietic stem cell transplantation (HSCT), the alloantigen-specific type 1 regulatory T-cells are tolerant to the alloantigens and suppress alloreactive immune responses by donor CD4+ and CD8+ T-cells. This may ultimately prevent GvHD. IL-10 plays a key role in controlling inflammation, down-regulating immune responses, and inducing immunological tolerance. IL-10 induces both a long lasting antigen specific T-cell anergy and the differentiation of TR1 cells."], "t": []}], "preferred_name": "Alloantigen-specific Allogeneic Type 1 Regulatory T Cells T-allo10", "taxa": []}
{"type": "biolink:Cell", "ic": 80.96785908349635, "identifiers": [{"i": "CL:0000448", "l": "white adipocyte", "d": ["An adipocyte with light coloration and few mitochondria. It contains a scant ring of cytoplasm surrounding a single large lipid droplet or vacuole."], "t": []}, {"i": "UMLS:C1720858", "l": "Adipocytes, White", "d": [], "t": []}, {"i": "MESH:D052438", "l": "Adipocytes, White", "d": [], "t": []}], "preferred_name": "white adipocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 78.29800561113302, "identifiers": [{"i": "CL:0002487", "l": "cutaneous/subcutaneous mechanoreceptor cell", "d": ["A neuronal receptor that respond to mechanical pressure or distortion in the skin."], "t": []}], "preferred_name": "cutaneous/subcutaneous mechanoreceptor cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4033064", "l": "uterine resident macrophage", "d": ["A tissue-resident macrophage that is part of the uterus."], "t": []}], "preferred_name": "uterine resident macrophage", "taxa": []}
{"type": "biolink:Cell", "ic": 62.07953880489281, "identifiers": [{"i": "CL:0000049", "l": "common myeloid progenitor", "d": ["A progenitor cell committed to myeloid lineage, including the megakaryocyte and erythroid lineages."], "t": []}, {"i": "UMLS:C0314588", "l": "Colony-Forming Units, Granulocyte-Erythroid-Macrophage-Megakaryocyte", "d": [], "t": []}, {"i": "SNOMEDCT:444993001", "l": "", "d": [], "t": []}], "preferred_name": "common myeloid progenitor", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0002289", "l": "type I taste bud cell", "d": ["A densely staining taste receptor cell that contains many dense vacuoles in their apical regions which project into the apical space and bear microvilli. This cell type serves as a supporting cell by surrounding and isolating the other cell types from each other; secrete a dense amorphous material that surrounds the microvilli in the taste pore. This cell type expresses a glial glutumate transporter, GLAST."], "t": []}, {"i": "UMLS:C1179124", "l": "Type I taste bud cell", "d": [], "t": []}], "preferred_name": "type I taste bud cell", "taxa": []}
{"type": "biolink:Cell", "ic": 66.748370386797, "identifiers": [{"i": "UMLS:C1514089", "l": "Neoplastic Small Lymphocyte", "d": [], "t": []}, {"i": "NCIT:C36998", "l": "Neoplastic Small Lymphocyte", "d": [], "t": []}], "preferred_name": "Neoplastic Small Lymphocyte", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5220572", "l": "Eosinophils|Urine/Urine sed", "d": [], "t": []}], "preferred_name": "Eosinophils|Urine/Urine sed", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5977928", "l": "Granulocytes | Peritoneal fluid | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Granulocytes | Peritoneal fluid | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0002042", "l": "immature NK T cell stage IV, mouse", "d": ["A CD24-low, CD44-positive, DX5-high, NK1.1-negative NK T cell."], "t": []}], "preferred_name": "immature NK T cell stage IV, mouse", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4518157", "l": "Population of all normal spermatozoa in portion of fluid", "d": [], "t": []}, {"i": "SNOMEDCT:726441008", "l": "", "d": [], "t": []}], "preferred_name": "Population of all normal spermatozoa in portion of fluid", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C6064594", "l": "Large unstained cell", "d": [], "t": []}, {"i": "SNOMEDCT:1382196001", "l": "", "d": [], "t": []}], "preferred_name": "Large unstained cell", "taxa": []}
{"type": "biolink:Cell", "ic": 63.18520211639759, "identifiers": [{"i": "CL:0000130", "l": "neuron associated cell (sensu Nematoda and Protostomia)", "d": [], "t": []}], "preferred_name": "neuron associated cell (sensu Nematoda and Protostomia)", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C2349679", "l": "Atypical cervical glandular cells NOS", "d": [], "t": []}], "preferred_name": "Atypical cervical glandular cells NOS", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C3272995", "l": "Lymphoma TAA-specific Cytotoxic T Lymphocytes", "d": [], "t": []}, {"i": "NCIT:C96736", "l": "Lymphoma TAA-specific Cytotoxic T Lymphocytes", "d": ["A population of autologous cytotoxic T lymphocytes (CTLs) with potential immunomodulating and antitumor activities. White blood cells are grown ex-vivo and are exposed to dendritic cells (DCs) loaded with lymphoma tumor associated antigens (TAAs); the TAA-specific CTLs are further expanded ex-vivo before being introduced into the patient. Upon infusion with TAA-specific CTLs, these CTLs may help activate tumor-specific CTL responses in the patient, thereby specifically killing TAA-expressing cancer cells and eventually inhibiting tumor cell proliferation."], "t": []}], "preferred_name": "Lymphoma TAA-specific Cytotoxic T Lymphocytes", "taxa": []}
{"type": "biolink:Cell", "ic": 58.02257256848848, "identifiers": [{"i": "CL:0000234", "l": "phagocyte", "d": ["Any cell capable of ingesting particulate matter via phagocytosis."], "t": []}, {"i": "UMLS:C0031307", "l": "Phagocytes", "d": [], "t": []}, {"i": "NCIT:C12657", "l": "Phagocytic Cell", "d": [], "t": []}, {"i": "MESH:D010586", "l": "Phagocytes", "d": [], "t": []}, {"i": "SNOMEDCT:73568005", "l": "", "d": [], "t": []}], "preferred_name": "phagocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C4733675", "l": "Autologous PRAME-targeting TCR-modified T Cells MDG1011", "d": [], "t": []}, {"i": "NCIT:C156136", "l": "Autologous PRAME-targeting TCR-modified T Cells MDG1011", "d": ["Human autologous T-lymphocytes transduced with a retroviral vector encoding a human leukocyte antigen (HLA)-A*02:01-restricted T-cell receptor (TCR) specific for the human tumor-associated antigen (TAA) preferentially expressed antigen in melanoma (PRAME) coupled to the CD3 signaling complex, with potential antineoplastic activity. Upon reintroduction into the patient, the autologous PRAME-targeting TCR-modified T cells MDG1011 target and bind to tumor cells expressing PRAME. This may induce cell death in and halt the growth of PRAME-expressing tumor cells. The TAA PRAME is overexpressed by a variety of cancer cell types."], "t": []}], "preferred_name": "Autologous PRAME-targeting TCR-modified T Cells MDG1011", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0546504", "l": "P.B. hematohistioblast", "d": [], "t": []}], "preferred_name": "P.B. hematohistioblast", "taxa": []}
{"type": "biolink:Cell", "ic": 58.62105745913859, "identifiers": [{"i": "CL:0008007", "l": "visceral muscle cell", "d": ["A muscle cell that is part of some visceral muscle."], "t": []}], "preferred_name": "visceral muscle cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4310120", "l": "striatal pthlh-expressing interneuron (Primate)", "d": ["A striatal pthlh-expressing interneuron of the Primates brain. These cells are located in the striatum . Reference transcriptomic data for this type can be found in the dataset/taxonomy - HMBA Basal Ganglia Consensus Taxonomy in cell set Group:STR FS PTHLH-PVALB GABA."], "t": []}], "preferred_name": "striatal pthlh-expressing interneuron (Primate)", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0002599", "l": "smooth muscle cell of the esophagus", "d": ["A smooth muscle cell of the esophagus."], "t": []}], "preferred_name": "smooth muscle cell of the esophagus", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C6055545", "l": "CAP-1002B", "d": [], "t": []}], "preferred_name": "CAP-1002B", "taxa": []}
{"type": "biolink:Cell", "ic": 71.06400748151069, "identifiers": [{"i": "UMLS:C1512140", "l": "ES Cell Line", "d": [], "t": []}, {"i": "NCIT:C20232", "l": "ES Cell Line", "d": ["Stable cell lines derived from embryonic stem cells.  They can be propagated indefinitely in the primitive undifferentiated state while remaining pluripotent."], "t": []}], "preferred_name": "ES Cell Line", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4300379", "l": "Erythrocytes.Babesia sp infected", "d": [], "t": []}], "preferred_name": "Erythrocytes.Babesia sp infected", "taxa": []}
{"type": "biolink:Cell", "ic": 90.871710685482, "identifiers": [{"i": "UMLS:C1513926", "l": "Neoplastic Astrocyte with Few Flaccid Processes", "d": [], "t": []}, {"i": "NCIT:C37135", "l": "Neoplastic Astrocyte with Few Flaccid Processes", "d": [], "t": []}], "preferred_name": "Neoplastic Astrocyte with Few Flaccid Processes", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5907943", "l": "Allogeneic Anti-CD33 CAR T-cells VCAR33", "d": [], "t": []}, {"i": "NCIT:C202016", "l": "Allogeneic Anti-CD33 CAR T-cells VCAR33", "d": ["A preparation of allogeneic T-lymphocytes, derived from the same matched healthy donor who provided a stem cell transplant and transduced with a lentiviral vector to express a chimeric antigen receptor (CAR) specific for the CD33 antigen, with potential immunomodulating and antineoplastic activities. Upon administration, allogeneic anti-CD33 CAR T-cells VCAR33 specifically recognize and kill CD33-expressing tumor cells. CD33 is expressed on normal non-pluripotent hematopoietic stem cells and is overexpressed on myeloid leukemia cells."], "t": []}], "preferred_name": "Allogeneic Anti-CD33 CAR T-cells VCAR33", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C2986886", "l": "Rapamycin-Polarized Th1/Tc1 Autologous T Lymphocytes", "d": [], "t": []}, {"i": "NCIT:C95080", "l": "Rapamycin-Polarized Th1/Tc1 Autologous T Lymphocytes", "d": ["A population of T lymphocytes polarized by rapamycin with potential immunomodulating activity. The autologous T cells collected from the patient were co-stimulated with antibodies to the T-cell cell surface proteins CD3 and CD28 and expanded ex vivo in the presence of rapamycin, an immunosuppressive drug, and then infused back into the same patient. Both CD3 and CD28 are required for full T-cell activation. These lymphocytes expressed anti-apoptotic bcl-2 family member proteins (reduced Bax, Bak; increased phospho-Bad); maintained mitochondrial membrane potentials; and displayed reduced apoptosis. Adoptive transfer of this type of T cell potentially induces an anti-apoptotic Th1/Tc1 effector phenotype by promoting autophagy."], "t": []}], "preferred_name": "Rapamycin-Polarized Th1/Tc1 Autologous T Lymphocytes", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5555854", "l": "Ex Vivo-expanded Allogeneic Gamma 9 Delta 2 T-cells", "d": [], "t": []}, {"i": "NCIT:C179664", "l": "Ex Vivo-expanded Allogeneic Gamma 9 Delta 2 T-cells", "d": ["A preparation of a subset of ex vivo-expanded, allogeneic T-lymphocytes that express gamma 9 delta 2 T-cell receptors (TCRs), with potential immunomodulating and antineoplastic activities. Upon administration of the ex vivo-expanded allogeneic gamma 9 delta 2 T-cells, these cells secrete interferon-gamma (IFN-g) and exert direct killing of tumor cells. In addition, these cells activate the immune system to exert a cytotoxic T-lymphocyte (CTL) response against tumor cells. Gamma delta T-lymphocytes play a key role in the activation of the immune system and do not require major histocompatibility complex (MHC)-mediated antigen presentation to exert their cytotoxic effect. Gamma 9 delta 2 T-cells, a subset of gamma delta T-cells, may have a stronger association with antitumor immune responses compared with other gamma delta T-cell subtypes."], "t": []}], "preferred_name": "Ex Vivo-expanded Allogeneic Gamma 9 Delta 2 T-cells", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5155172", "l": "Blasts | Synovial fluid | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Blasts | Synovial fluid | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": 68.26004206441749, "identifiers": [{"i": "UMLS:C1513989", "l": "Neoplastic Immunoblast", "d": [], "t": []}, {"i": "NCIT:C37009", "l": "Neoplastic Immunoblast", "d": [], "t": []}], "preferred_name": "Neoplastic Immunoblast", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1514295", "l": "Pre-Thymocyte", "d": [], "t": []}, {"i": "NCIT:C33399", "l": "Pre-Thymocyte", "d": [], "t": []}], "preferred_name": "Pre-Thymocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:2000080", "l": "mesenchymal stem cell of abdominal adipose tissue", "d": ["Any mesenchymal stem cell of adipose tissue that is part of an abdomen."], "t": []}], "preferred_name": "mesenchymal stem cell of abdominal adipose tissue", "taxa": []}
{"type": "biolink:Cell", "ic": 92.76600187037766, "identifiers": [{"i": "CL:4030050", "l": "D1/D2-hybrid medium spiny neuron", "d": ["A medium spiny neuron that expresses both DRD1 and DRD2 and is part of an extra-striosomal part of dorsal striatum."], "t": []}], "preferred_name": "D1/D2-hybrid medium spiny neuron", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5853556", "l": "allogeneic mesenchymal stem cells derived neuronal regeneration promoting cells", "d": [], "t": []}], "preferred_name": "allogeneic mesenchymal stem cells derived neuronal regeneration promoting cells", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C4085971", "l": "Anti-Epidermal Growth Factor Receptor 2 Antibody Expressing Pluripotent Killer T-Lymphocytes", "d": [], "t": []}, {"i": "NCIT:C125633", "l": "Anti-Epidermal Growth Factor Receptor 2 Antibody Expressing Pluripotent Killer T-Lymphocytes", "d": ["A specific population of pluripotent killer (PIK) T-cells that have been induced to express high levels of antibodies against human epidermal growth factor receptor 2 (ERBB2; HER2), with potential antitumor activity. Although the exact mechanism(s) of action through which PIK-HER2 cells exert their effects has yet to be elucidated, upon infusion, these cells secrete antibodies targeting HER2 expressed on the surface of tumor cells. This may inhibit HER2-dependent signaling, which may lead to inhibition of cellular proliferation and differentiation. Additionally, these cells may stimulate the host immune system to mount both a highly-specific cytotoxic T-lymphocyte (CTL) response and antibody-dependent cell cytotoxicity (ADCC) directed against HER2-overexpressing tumors, which leads to tumor cell lysis. HER2 is a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases and is frequently overexpressed in solid tumors."], "t": []}], "preferred_name": "Anti-Epidermal Growth Factor Receptor 2 Antibody Expressing Pluripotent Killer T-Lymphocytes", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5151351", "l": "Abnormal lymphocytes | Synovial fluid | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Abnormal lymphocytes | Synovial fluid | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4040006", "l": "dermal chromatophore", "d": ["A chromatophore that is part of the dermis."], "t": []}], "preferred_name": "dermal chromatophore", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1440367", "l": "Cells.CD90", "d": [], "t": []}], "preferred_name": "Cells.CD90", "taxa": []}
{"type": "biolink:Cell", "ic": 76.9766555310214, "identifiers": [{"i": "UMLS:C1512102", "l": "Dysplastic Erythroid Precursor", "d": [], "t": []}, {"i": "NCIT:C37054", "l": "Dysplastic Erythroid Precursor", "d": [], "t": []}], "preferred_name": "Dysplastic Erythroid Precursor", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0002291", "l": "X chromosome-bearing sperm cell", "d": ["A sperm bearing an X chromosome. Chromosomal and genetic sex is established at fertilization in mammals and depends upon whether an X-bearing sperm or a Y-bearing sperm fertilizes the X-bearing ovum."], "t": []}], "preferred_name": "X chromosome-bearing sperm cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5216204", "l": "Eosinophils|NCnc|Pt|Plr fld", "d": [], "t": []}], "preferred_name": "Eosinophils|NCnc|Pt|Plr fld", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C4727433", "l": "Allogeneic CD34-positive E-rosetted T-cell Depleted Peripheral Blood Stem Cells", "d": [], "t": []}, {"i": "NCIT:C153885", "l": "Allogeneic CD34-positive E-rosetted T-cell Depleted Peripheral Blood Stem Cells", "d": ["A preparation of CD34+ selected peripheral blood stem cells (PBSCs) that are depleted of T-cells via erythrocyte rosetting (E-rosetting) and intended for allogeneic stem cell transplant. Administration of this particular preparation of CD34+E- T-cell depleted PBSCs may potentially reduce the occurrence of graft-versus-host disease (GvHD) without increasing the risk of graft failure or poor graft function"], "t": []}], "preferred_name": "Allogeneic CD34-positive E-rosetted T-cell Depleted Peripheral Blood Stem Cells", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0002459", "l": "langerin-negative dermal dendritic cell", "d": ["A dermal dendritic cell that is langerin-negative, CD103-negative, and CD11b-positive."], "t": []}], "preferred_name": "langerin-negative dermal dendritic cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5382754", "l": "CD21lowCD38- cells | Blood | Cell markers", "d": [], "t": []}], "preferred_name": "CD21lowCD38- cells | Blood | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C3831071", "l": "cMet CAR-mRNA Electroporated Autologous T Lymphocytes", "d": [], "t": []}, {"i": "NCIT:C106230", "l": "cMet CAR-mRNA Electroporated Autologous T Lymphocytes", "d": ["A preparation of autologous T-lymphocytes that have been electroporated with an mRNA encoding a chimeric antigen receptor (CAR) consisting of an anti-human hepatocyte growth factor receptor (HGFR or cMet) scFv (single chain variable fragment) and the zeta chain of the TCR/CD3 complex (CD3-zeta) coupled to the co-stimulatory molecule 4-1BB (CD137), with potential antineoplastic activities. Upon intratumoral administration, cMet CAR-mRNA electroporated autologous T lymphocytes direct T-cells to cMet-expressing tumor cells, which induces a selective toxicity in cMet-expressing tumor cells and causes tumor cell lysis. The 4-1BB co-stimulatory molecule signaling domain enhances activation and signaling after recognition of cMet. The inclusion of the 4-1BB signaling domain may increase the antitumor activity as compared to the inclusion of the CD3-zeta chain alone. The mRNA CAR is expressed for a limited amount of time, which can prevent serious, unforeseen side effects. cMet, a receptor tyrosine kinase overexpressed or mutated in many tumor cell types, plays a key role in cancer cell growth, survival, angiogenesis, invasion, and metastasis."], "t": []}], "preferred_name": "cMet CAR-mRNA Electroporated Autologous T Lymphocytes", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5155100", "l": "Bizarre cells | Blood | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Bizarre cells | Blood | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "CL:0002122", "l": "B220-positive CD38-positive IgG-negative class switched memory B cell", "d": ["A B220-positive CD38-positive IgG-negative memory B cell is a CD38-positive IgG-negative class switched memory B cell that lacks IgG on the cell surface with the phenotype B220-positive, CD38-positive, and IgG-negative."], "t": []}], "preferred_name": "B220-positive CD38-positive IgG-negative class switched memory B cell", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "CL:0002527", "l": "immature CD14-positive dermal dendritic cell", "d": ["An immature CD14-positive dermal dendritic cell is CD80-low, CD86-low, and MHCII-low."], "t": []}], "preferred_name": "immature CD14-positive dermal dendritic cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C4724836", "l": "Autologous PD-1 Antibody-expressing Mesothelin-specific CAR-T Cells", "d": [], "t": []}, {"i": "NCIT:C148133", "l": "Autologous PD-1 Antibody-expressing Mesothelin-specific CAR-T Cells", "d": ["Genetically modified, autologous T-lymphocytes that express an antibody that targets the negative immunoregulatory human cell surface receptor programmed cell death protein 1 (PD-1; PDCD1; CD279) and are transduced with a gene encoding a chimeric antigen receptor (CAR) specific for the human tumor-associated antigen (TAA) mesothelin, with potential immunomodulating and antineoplastic activities. After isolation, transduction, expansion in culture, and reintroduction into the patient, the autologous PD-1 antibody expressing mesothelin specific CAR-T cells specifically target and kill mesothelin-expressing tumor cells. The anti-PD-1 expressed on the CAR-T cells binds to PD-1 expressed on T-cells and prevents the interaction of PD-1 with its ligand programmed cell death 1 ligand 1 (PD-L1, PD-1L1; CD274) expressed on cancer cells, which prevents PD-1-mediated signaling and T-cell exhaustion, enhances T-cell activation, and results in enhanced toxicity in mesothelin-expressing tumor cells. PD-1, an immunoglobulin (Ig) superfamily transmembrane protein and inhibitory receptor, negatively regulates T-cell activation and overexpression within the tumor microenvironment and inhibits T-cell function. Mesothelin, a cell surface glycoprotein involved in cell adhesion, is overexpressed in a variety of cancer cell types."], "t": []}], "preferred_name": "Autologous PD-1 Antibody-expressing Mesothelin-specific CAR-T Cells", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "UMLS:C5554732", "l": "Malignant Epithelioid Cell with Abundant Eosinophilic Cytoplasm", "d": [], "t": []}, {"i": "NCIT:C177900", "l": "Malignant Epithelioid Cell with Abundant Eosinophilic Cytoplasm", "d": ["A malignant cell resembling an epithelial cell and exhibiting abundant eosinophilic cytoplasm."], "t": []}], "preferred_name": "Malignant Epithelioid Cell with Abundant Eosinophilic Cytoplasm", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0004124", "l": "retinal ganglion cell C1", "d": ["A retinal ganglion cell C inner that has medium dendritic diversity."], "t": []}], "preferred_name": "retinal ganglion cell C1", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1979636", "l": "Blasts.CD11c", "d": [], "t": []}], "preferred_name": "Blasts.CD11c", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4033139", "l": "ciliary ganglion VIP/PHI neuron", "d": ["A parasympathetic postganglionic neuron whose soma is located in the ciliary ganglion and that co-expresses vasoactive intestinal peptide (VIP) and peptide histidine isoleucine (PHI, both encoded by the VIP gene). This neuron provides parasympathetic innervation to the eye, contributing to regulation of pupillary constriction and ciliary muscle accommodation. It has been identified in human ciliary ganglia by immunohistochemistry (Kiyokawa et al. 2012, PMID:22095632). VIP/PHI co-expression distinguishes this subpopulation from other cholinergic parasympathetic neurons in the ciliary ganglion and is characteristic of a subset of cranial parasympathetic neurons in humans and other mammals."], "t": []}], "preferred_name": "ciliary ganglion VIP/PHI neuron", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C2326946", "l": "Goblet cell of epithelium of duodenal gland", "d": [], "t": []}], "preferred_name": "Goblet cell of epithelium of duodenal gland", "taxa": []}
{"type": "biolink:Cell", "ic": 56.47962383430287, "identifiers": [{"i": "UMLS:C4727509", "l": "Genetically-engineered Cell", "d": [], "t": []}, {"i": "NCIT:C154231", "l": "Genetically-engineered Cell", "d": ["Autologous or allogeneic cells that have been genetically modified."], "t": []}], "preferred_name": "Genetically-engineered Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 80.96785908349635, "identifiers": [{"i": "CL:0000510", "l": "paneth cell", "d": ["An epithelial cell found in the basal part of the intestinal glands (crypts of Lieberkuhn) including the appendix. Paneth cells synthesize and secrete lysozyme and cryptdins. Numerous in the deeper parts of the intestinal crypts, particularly in the duodenum, rich in zinc, contain large acidophilic granules, with irregular apical microvilli and prominent membrane-bound vacuoles containing matrix."], "t": []}, {"i": "UMLS:C0227276", "l": "Paneth Cells", "d": [], "t": []}, {"i": "NCIT:C12593", "l": "Paneth Cell", "d": ["A granule-rich columnar epithelial cell found in the mucous membrane lining at the base of the small intestine crypts of Lieberkühn. Paneth Cells secrete antimicrobial peptides that contribute to microbial density in the lumen of the small intestine and in the maintenance of the gastrointestinal barrier."], "t": []}, {"i": "MESH:D019879", "l": "Paneth Cells", "d": [], "t": []}, {"i": "SNOMEDCT:84907006", "l": "", "d": [], "t": []}], "preferred_name": "paneth cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5853687", "l": "Allogeneic natural killer cells", "d": [], "t": []}], "preferred_name": "Allogeneic natural killer cells", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1267822", "l": "CD4+ CD25+ Regulatory T Cells", "d": [], "t": []}, {"i": "NCIT:C78829", "l": "CD4+ CD25+ Regulatory T Cells", "d": ["Regulatory T cells that express CD4 and CD25 (interleukin 2 receptor) antigens, with immunomodulating activity. CD4+CD25+ T regulatory cells (Tregs), a subset of CD4+ T cells expressing high levels of CD25 and the transcription factor Foxp3, are essential in maintaining immunologic homeostasis, preventing autoimmunity by suppressing self-reactive T cells; CD4+CD25+ Tregs may induce tolerance to allogeneic organ transplants such as hematopoetic stem cell transplants (HSCTs)."], "t": []}, {"i": "SNOMEDCT:115399009", "l": "", "d": [], "t": []}], "preferred_name": "CD4+ CD25+ Regulatory T Cells", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0004242", "l": "WF3-1 amacrine cell", "d": ["An amacrine cell with a wide dendritic field, dendrites in S3, and post-synaptic terminals in S3. Dendrites of this cell type are straight and minimally branched."], "t": []}], "preferred_name": "WF3-1 amacrine cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0772149", "l": "red blood cells,dehydrated", "d": [], "t": []}], "preferred_name": "red blood cells,dehydrated", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0001041", "l": "CD8-positive, CXCR3-positive, alpha-beta regulatory T cell", "d": ["A CD8-positive alpha-beta-positive T cell with the phenotype CXCR3-positive and having suppressor function. They are capable of producing IL-10, suppressing proliferation, and suppressing IFN-gamma production."], "t": []}], "preferred_name": "CD8-positive, CXCR3-positive, alpha-beta regulatory T cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4033070", "l": "cycling dendritic cell", "d": ["A(n) dendritic cell that is cycling."], "t": []}], "preferred_name": "cycling dendritic cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0598536", "l": "follicular epithelial cell", "d": [], "t": []}], "preferred_name": "follicular epithelial cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C4329669", "l": "Circulating Myeloid Cell", "d": [], "t": []}, {"i": "NCIT:C129907", "l": "Circulating Myeloid Cell", "d": ["A myeloid-derived cell found in the peripheral blood."], "t": []}], "preferred_name": "Circulating Myeloid Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 79.07356789860069, "identifiers": [{"i": "UMLS:C1517440", "l": "Ganglion-Like Cell", "d": [], "t": []}, {"i": "NCIT:C36981", "l": "Ganglion-Like Cell", "d": [], "t": []}], "preferred_name": "Ganglion-Like Cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0684117", "l": "prokaryoblast", "d": [], "t": []}], "preferred_name": "prokaryoblast", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4697024", "l": "CD27+IgD-IgM+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:1373242009", "l": "", "d": [], "t": []}], "preferred_name": "CD27+IgD-IgM+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0229651", "l": "Promegakaryocytes", "d": [], "t": []}, {"i": "SNOMEDCT:50284009", "l": "", "d": [], "t": []}], "preferred_name": "Promegakaryocytes", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5690733", "l": "M Cells, Bronchiolar", "d": [], "t": []}], "preferred_name": "M Cells, Bronchiolar", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5180576", "l": "Segmented neutrophils | Cerebral spinal fluid | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Segmented neutrophils | Cerebral spinal fluid | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1522254", "l": "Mouse Theca Cell", "d": [], "t": []}, {"i": "NCIT:C22666", "l": "Mouse Theca Cell", "d": [], "t": []}], "preferred_name": "Mouse Theca Cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5163717", "l": "Erythrocytes | Fetus | Blood | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Erythrocytes | Fetus | Blood | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4510923", "l": "Blast cell positive for CD2 antigen", "d": [], "t": []}, {"i": "SNOMEDCT:725175007", "l": "", "d": [], "t": []}], "preferred_name": "Blast cell positive for CD2 antigen", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1525455", "l": "CD33+CD34+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:1373021000", "l": "", "d": [], "t": []}], "preferred_name": "CD33+CD34+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1511008", "l": "BG03", "d": [], "t": []}, {"i": "NCIT:C20235", "l": "BG03", "d": ["Provider: BresaGen, Inc., Athens, GA. Information from provider and not independently verified by NIH: Cells are positive for cell markers SSEA-3, SSEA-4, TRA 1-60, TRA 1-81, Oct-4, and alkaline phosphatase; Cells are negative for the cell marker SSEA1. This cell line meets the criteria for the use of human embryonic stem cells by federally funded researchers."], "t": []}], "preferred_name": "BG03", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4033059", "l": "lactocyte type 1", "d": ["A lactocyte that highly expresses genes associated with transcription, immune cell function, and cellular stress. A lactocyte type 1 also expresses genes involved in milk component biosynthesis (e.g., LALBA and CSNs), albeit at lower levels than a lactocyte type 2."], "t": []}], "preferred_name": "lactocyte type 1", "taxa": []}
{"type": "biolink:Cell", "ic": 92.76600187037766, "identifiers": [{"i": "CL:0000866", "l": "thymic macrophage", "d": ["A tissue-resident macrophage resident found in the thymus, involved in the clearance of apoptotic thymocytes."], "t": []}], "preferred_name": "thymic macrophage", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4030041", "l": "luminal endometrial multiciliated epithelial cell", "d": ["A ciliated cell of the endometrial luminal epithelium. This cell is characterized by the presence of motile cilia on its apical surface."], "t": []}], "preferred_name": "luminal endometrial multiciliated epithelial cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1116267", "l": "Cells.CD3+IL2R1+", "d": [], "t": []}], "preferred_name": "Cells.CD3+IL2R1+", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C3273206", "l": "Anti-mesothelin CIR mRNA-electroporated Autologous T Cells", "d": [], "t": []}, {"i": "NCIT:C97038", "l": "Anti-mesothelin CIR mRNA-electroporated Autologous T Cells", "d": ["Autologous chimeric immune receptor (CIR) T cells transfected with anti-mesothelin chimeric T cell receptor mRNA, with potential antineoplastic activity. The anti-mesothelin mRNA encodes a single chain antibody variable fragment (ScFv), the intracellular CD 3 zeta T cell receptor domain and the 4-1BB (cd137) costimulatory domain. Upon intravenous administration, the anti-mesothelin CIR mRNA-electroporated autologous T cells may attach to cancer cells expressing mesothelin. This may stimulate the secretion of multiple cytokines and may result in cell lysis of mesothelin-expressing cancer cells. Mesothelin is a cell surface glycoprotein involved in cell adhesion and is overexpressed in many epithelial-derived cancers."], "t": []}], "preferred_name": "Anti-mesothelin CIR mRNA-electroporated Autologous T Cells", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0009035", "l": "stromal cell of lamina propria of vermiform appendix", "d": ["A stromal cell found in the lamina propria of the vermiform appendix."], "t": []}], "preferred_name": "stromal cell of lamina propria of vermiform appendix", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:1000489", "l": "reticular cell of splenic cord", "d": ["A reticular cell that is part of the splenic cord."], "t": []}, {"i": "UMLS:C2328655", "l": "Reticular cell of splenic cord", "d": [], "t": []}], "preferred_name": "reticular cell of splenic cord", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5178309", "l": "Promyelocytes | Fetus | Blood | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Promyelocytes | Fetus | Blood | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4267786", "l": "CD27-CD45RA- cell", "d": [], "t": []}, {"i": "SNOMEDCT:1373173002", "l": "", "d": [], "t": []}], "preferred_name": "CD27-CD45RA- cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5706348", "l": "Anti-Claudin18.2 CAR-T Cells IM92", "d": [], "t": []}, {"i": "NCIT:C187104", "l": "Anti-Claudin18.2 CAR-T Cells IM92", "d": ["A preparation of T-lymphocytes engineered to express a chimeric antigen receptor (CAR) specific for the tumor-associated antigen (TAA) Claudin18.2 (CLDN18.2; A2 isoform of claudin-18), with potential immunostimulating and antineoplastic activities. Upon administration, anti-CLDN18.2 CAR-T cells IM92 specifically recognize and induce selective toxicity in CLDN18.2-expressing tumor cells. CLDN18.2, a tight junction protein, is expressed on a variety of tumor cells, but its expression in healthy tissues is strictly confined to short-lived differentiated epithelial cells of the gastric mucosa."], "t": []}], "preferred_name": "Anti-Claudin18.2 CAR-T Cells IM92", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5157343", "l": "CD19 blasts | Bone marrow | Cell markers", "d": [], "t": []}], "preferred_name": "CD19 blasts | Bone marrow | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5572423", "l": "Erythrocytes.ghost cells | Urine sediment | Urinalysis", "d": [], "t": []}], "preferred_name": "Erythrocytes.ghost cells | Urine sediment | Urinalysis", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5421409", "l": "Anti-HER2 oNK Cells", "d": [], "t": []}], "preferred_name": "Anti-HER2 oNK Cells", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1507329", "l": "Cells.t(6;9)(p22;q34)(DEK,NUP214)", "d": [], "t": []}], "preferred_name": "Cells.t(6;9)(p22;q34)(DEK,NUP214)", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4052038", "l": "tuft cell of nasal cavity respiratory epithelium", "d": ["A tuft cell that is part of the nasal cavity respiratory epithelium. Acting as a chemosensor, it detects bitter taste ligands and bacterial signals via taste receptors, maintaining epithelial-microbial homeostasis by stimulating antimicrobial peptide secretion from adjacent epithelial cells. This cell is a major source of IL-25, promoting type 2 immune responses and potentially contributing to chronic rhinosinusitis (O'Leary et al., 2019)."], "t": []}], "preferred_name": "tuft cell of nasal cavity respiratory epithelium", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1440055", "l": "Abnormal blood cells.CD5", "d": [], "t": []}], "preferred_name": "Abnormal blood cells.CD5", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4515377", "l": "Entire endocrine pancreas cell", "d": [], "t": []}, {"i": "SNOMEDCT:730209004", "l": "", "d": [], "t": []}], "preferred_name": "Entire endocrine pancreas cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5175004", "l": "Normoblasts | Blood | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Normoblasts | Blood | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0597661", "l": "visual photoreceptor", "d": [], "t": []}], "preferred_name": "visual photoreceptor", "taxa": []}
{"type": "biolink:Cell", "ic": 79.64650900338474, "identifiers": [{"i": "UMLS:C1510956", "l": "Atypical Histiocyte", "d": [], "t": []}, {"i": "NCIT:C40999", "l": "Atypical Histiocyte", "d": [], "t": []}], "preferred_name": "Atypical Histiocyte", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1267865", "l": "Lymphocyte positive for both CD11 antigen and CD20 antigen", "d": [], "t": []}, {"i": "SNOMEDCT:117546000", "l": "", "d": [], "t": []}], "preferred_name": "Lymphocyte positive for both CD11 antigen and CD20 antigen", "taxa": []}
{"type": "biolink:Cell", "ic": 83.63771255585968, "identifiers": [{"i": "CL:4023074", "l": "mammillary body neuron", "d": ["A neuron that has its soma located in the mammillary body."], "t": []}], "preferred_name": "mammillary body neuron", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4030038", "l": "CD24-positive, CD-133-positive, vimentin-positive proximal tubular cell", "d": ["A CD24-positive, CD-133-positive, vimentin-positive cell found scattered throughout a renal proximal tubule and that may participate in tubular regeneration. Compared to other proximal tubular cell types, this cell contains less cytoplasm, fewer mitochondria and no brush border."], "t": []}], "preferred_name": "CD24-positive, CD-133-positive, vimentin-positive proximal tubular cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5153167", "l": "Anulocytes | Blood | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Anulocytes | Blood | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C2328288", "l": "Set of Ch4 cholinergic cells", "d": [], "t": []}], "preferred_name": "Set of Ch4 cholinergic cells", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5216192", "l": "Basophils|NCnc|Pt|Periton fld", "d": [], "t": []}], "preferred_name": "Basophils|NCnc|Pt|Periton fld", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5157375", "l": "CD2+CD3+ cells | XXX | Cell markers", "d": [], "t": []}], "preferred_name": "CD2+CD3+ cells | XXX | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1440251", "l": "CD120b+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:1372830000", "l": "", "d": [], "t": []}], "preferred_name": "CD120b+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4267791", "l": "CD27-CD45RA+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:1373174008", "l": "", "d": [], "t": []}], "preferred_name": "CD27-CD45RA+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5155165", "l": "Blasts | Blood | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Blasts | Blood | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:2000059", "l": "prostate gland microvascular endothelial cell", "d": ["Any microvascular endothelial cell that is part of a prostate gland."], "t": []}], "preferred_name": "prostate gland microvascular endothelial cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5167388", "l": "Histiocytes | Urine sediment | Urinalysis", "d": [], "t": []}], "preferred_name": "Histiocytes | Urine sediment | Urinalysis", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4518154", "l": "Population of all spermatozoa with abnormal tail in portion of fluid", "d": [], "t": []}, {"i": "SNOMEDCT:725227009", "l": "", "d": [], "t": []}], "preferred_name": "Population of all spermatozoa with abnormal tail in portion of fluid", "taxa": []}
{"type": "biolink:Cell", "ic": 89.40238429118027, "identifiers": [{"i": "CL:1000768", "l": "kidney connecting tubule epithelial cell", "d": ["Any nephron tubule epithelial cell that is part of some renal connecting tubule."], "t": []}], "preferred_name": "kidney connecting tubule epithelial cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C6021989", "l": "Epithelial cells | Sputum | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Epithelial cells | Sputum | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": 80.27409497666227, "identifiers": [{"i": "CL:1001319", "l": "bladder cell", "d": ["Any cell that is part of some urinary bladder."], "t": []}], "preferred_name": "bladder cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4307084", "l": "CHOR NN_1 Tbc1d1 choroid plexus epithelial cell (Mmus)", "d": ["A choroid plexus epithelial cell of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of 2900040C04Rik (Mmus), Tbc1d1 (Mmus). It is distinguished from other CHOR NN cells by expression of Tbc1d1. These cells are located in the Cerebellum, brain , in or close to the regions: Paraflocculus, choroid plexus . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5264 CHOR NN_1."], "t": []}], "preferred_name": "CHOR NN_1 Tbc1d1 choroid plexus epithelial cell (Mmus)", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5555583", "l": "CXCR4-modified Anti-BCMA CAR T Cells", "d": [], "t": []}, {"i": "NCIT:C179284", "l": "CXCR4-modified Anti-BCMA CAR T Cells", "d": ["A preparation of T-lymphocytes that have been genetically engineered to express a chimeric antigen receptor (CAR) targeting the tumor-associated antigen (TAA) B-cell maturation antigen (BCMA; TNFRSF17) with modification of the C-X-C chemokine receptor type 4 (CXCR4), with potential immunomodulating and antineoplastic activities. Upon administration, the CXCR4-modified anti-BCMA CAR T cells target and bind to tumor cells expressing BCMA and induce selective cytotoxicity in those tumor cells. The modification of the stromal-cell derived factor-1 (SDF-1 or CXCL12) receptor CXCR4 may improve the penetration of CAR T cells into the tumor microenvironment (TME). BCMA, a receptor for both a proliferation-inducing ligand (APRIL) and B-cell activating factor (BAFF), is a member of the tumor necrosis factor receptor superfamily (TNFRSF). BCMA is found on the surfaces of plasma cells, is overexpressed on malignant plasma cells and plays a key role in plasma cell proliferation and survival."], "t": []}], "preferred_name": "CXCR4-modified Anti-BCMA CAR T Cells", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1317188", "l": "CD13+CD33+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:1372967007", "l": "", "d": [], "t": []}], "preferred_name": "CD13+CD33+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": 61.52219502804027, "identifiers": [{"i": "CL:1000497", "l": "kidney cell", "d": ["A cell that is part of a kidney."], "t": []}], "preferred_name": "kidney cell", "taxa": []}
{"type": "biolink:Cell", "ic": 82.16838616155795, "identifiers": [{"i": "CL:0000060", "l": "odontoblast", "d": ["Skeletogenic cell that secretes dentine matrix, is derived from the odontogenic papilla, and develops from a preodontoblast cell."], "t": []}, {"i": "UMLS:C0028875", "l": "Odontoblasts", "d": [], "t": []}, {"i": "NCIT:C12567", "l": "Odontoblast", "d": ["A cell derived from a preodontoblast that secretes predentin. Each odontoblast has a cytoplasmic extension, an odontoblastic process that traverses the thickness of the dentin and helps to maintain the dentin."], "t": []}, {"i": "MESH:D009804", "l": "Odontoblasts", "d": [], "t": []}], "preferred_name": "odontoblast", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C3178741", "l": "Be2 Cells", "d": [], "t": []}], "preferred_name": "Be2 Cells", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5157441", "l": "CD3+CD4+CD27+CD62L+ cells | Blood | Cell markers", "d": [], "t": []}], "preferred_name": "CD3+CD4+CD27+CD62L+ cells | Blood | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5180941", "l": "Siderocytes | Blood | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Siderocytes | Blood | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4033043", "l": "lung interstitial macrophage", "d": ["A macrophage that is part of the lung connective tissue (pulmonary interstitium). This cell performs tissue remodeling and contributes to barrier immunity through antigen presentation."], "t": []}], "preferred_name": "lung interstitial macrophage", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5157612", "l": "CD55 Monocytes | Blood | Cell markers", "d": [], "t": []}], "preferred_name": "CD55 Monocytes | Blood | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "CL:0002560", "l": "inner root sheath cell", "d": ["An epithelial cell that resides in the inner root sheath of the hair follicle."], "t": []}], "preferred_name": "inner root sheath cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0314596", "l": "Spleen colony-forming unit", "d": [], "t": []}, {"i": "SNOMEDCT:445288000", "l": "", "d": [], "t": []}], "preferred_name": "Spleen colony-forming unit", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4038492", "l": "Cells.diploid.G1 phase", "d": [], "t": []}], "preferred_name": "Cells.diploid.G1 phase", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5221011", "l": "Myeloblasts|NCnc|Pt|Bld", "d": [], "t": []}], "preferred_name": "Myeloblasts|NCnc|Pt|Bld", "taxa": []}
{"type": "biolink:Cell", "ic": 53.70413169733774, "identifiers": [{"i": "UMLS:C0085133", "l": "Reed-Sternberg Cells", "d": [], "t": []}, {"i": "NCIT:C12660", "l": "Reed-Sternberg Cell", "d": [], "t": []}, {"i": "MESH:D016539", "l": "Reed-Sternberg Cells", "d": [], "t": []}, {"i": "SNOMEDCT:32915009", "l": "", "d": [], "t": []}], "preferred_name": "Reed-Sternberg Cells", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:2000058", "l": "calvarial osteoblast", "d": ["Any osteoblast that is part of a skull."], "t": []}], "preferred_name": "calvarial osteoblast", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5959675", "l": "Autologous IL-7-expressing TILs ADP-TILIL7", "d": [], "t": []}, {"i": "NCIT:C206256", "l": "Autologous IL-7-expressing TILs ADP-TILIL7", "d": ["A preparation of autologous tumor infiltrating lymphocytes (TILs) engineered to express the cytokine interleukin-7 (IL-7), with potential immunomodulating and antineoplastic activities. The TILs are isolated from an autologous tumor sample and transduced with a lentiviral vector to express IL-7. Upon infusion of the autologous IL-7-expressing TILs ADP-TILIL7 back into the patient, the TILs specifically recognize, target and kill the patient's tumor cells. IL-7 is a cytokine that promotes the proliferation and survival of T-cells and may enhance the activity and durability of the TILs."], "t": []}], "preferred_name": "Autologous IL-7-expressing TILs ADP-TILIL7", "taxa": []}
{"type": "biolink:Cell", "ic": 70.37024337467663, "identifiers": [{"i": "UMLS:C1510733", "l": "Abnormal Neutrophil", "d": [], "t": []}, {"i": "NCIT:C37029", "l": "Abnormal Neutrophil", "d": [], "t": []}], "preferred_name": "Abnormal Neutrophil", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5984678", "l": "Autologous Anti-CD19/CD20/CD22 CAR T-cells", "d": [], "t": []}, {"i": "NCIT:C213125", "l": "Autologous Anti-CD19/CD20/CD22 CAR T-cells", "d": ["A preparation of autologous T-lymphocytes engineered to express a chimeric antigen receptor (CAR) specific for the tumor-associated antigens (TAAs) cluster of differentiation 19 (CD19), CD20 and CD22, with potential immunostimulating and antineoplastic activities. Upon administration, autologous anti-CD19/CD20/CD22 CAR T-cells target and bind to CD19, CD20 and CD22 expressed on the surface of certain tumor cells. This induces selective toxicity in tumor cells expressing these TAAs. CD19, CD20 and CD22 are B-cell-specific cell surface antigens overexpressed in B-cell lineage malignancies."], "t": []}], "preferred_name": "Autologous Anti-CD19/CD20/CD22 CAR T-cells", "taxa": []}
{"type": "biolink:Cell", "ic": 67.99974458133127, "identifiers": [{"i": "UMLS:C1512971", "l": "Malignant Thyroid Gland Follicular Cell", "d": [], "t": []}, {"i": "NCIT:C36836", "l": "Malignant Thyroid Gland Follicular Cell", "d": [], "t": []}], "preferred_name": "Malignant Thyroid Gland Follicular Cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C6070318", "l": "Cells.recipient", "d": [], "t": []}], "preferred_name": "Cells.recipient", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0945925", "l": "CD3+CD25+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:1373005005", "l": "", "d": [], "t": []}], "preferred_name": "CD3+CD25+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "CL:4030047", "l": "matrix D2 medium spiny neuron", "d": ["A DRD2-expressing medium spiny neuron that is part of a matrix compartment of dorsal striatum."], "t": []}], "preferred_name": "matrix D2 medium spiny neuron", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0000361", "l": "gastrula cell", "d": ["A cell of the embryo in the early stage following the blastula, characterized by morphogenetic cell movements, cell differentiation, and the formation of the three germ layers."], "t": []}], "preferred_name": "gastrula cell", "taxa": []}
{"type": "biolink:Cell", "ic": 81.743421370964, "identifiers": [{"i": "UMLS:C1514178", "l": "Pleomorphic Reed-Sternberg Cell", "d": [], "t": []}, {"i": "NCIT:C38423", "l": "Pleomorphic Reed-Sternberg Cell", "d": [], "t": []}], "preferred_name": "Pleomorphic Reed-Sternberg Cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4246480", "l": "Non-ectomesenchymal cell", "d": [], "t": []}], "preferred_name": "Non-ectomesenchymal cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0002125", "l": "CD27-negative gamma-delta T cell", "d": ["A circulating gamma-delta T cell that expresses RORgamma(t), is CD27-negative and is capable of IL-17 secretion."], "t": []}], "preferred_name": "CD27-negative gamma-delta T cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4033027", "l": "diffuse bipolar 1 cell", "d": ["An OFF diffuse bipolar cell that makes synaptic contact with both L/M and S-cone photoreceptors and only minimal contact with rod photoreceptors."], "t": []}], "preferred_name": "diffuse bipolar 1 cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:1000363", "l": "transitional myocyte of atrial branch of anterior internodal tract", "d": ["A transitional myocyte that is part of the atrial branch of anterior internodal tract."], "t": []}, {"i": "UMLS:C2338473", "l": "Transitional myocyte of atrial branch of anterior internodal tract", "d": [], "t": []}], "preferred_name": "transitional myocyte of atrial branch of anterior internodal tract", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0003035", "l": "M6 retinal ganglion cell", "d": ["A monostratified retinal ganglion cell that contains opsin."], "t": []}], "preferred_name": "M6 retinal ganglion cell", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "CL:0020009", "l": "prototypic neuron", "d": ["A GABAergic neuron located in the external globus pallidus (GPe) that constitutes approximately two-thirds of all GPe neurons (Mallet et al., 2012, Dodson et al., 2015). Derived from the medial ganglionic eminence, this cell selectively expresses Nkx2-1, with roughly two-thirds co-expressing parvalbumin (PV) and one-third lacking it in mice (Mallet et al., 2012; Dodson et al., 2015)."], "t": []}], "preferred_name": "prototypic neuron", "taxa": []}
{"type": "biolink:Cell", "ic": 76.9766555310214, "identifiers": [{"i": "CL:0005026", "l": "hepatoblast", "d": ["Multi fate stem cell that gives rise to both hepatocytes and cholangiocytes as descendants. The term often refers to fetal precursors of hepatocytes (differently from 'hepatic stem cell', usually applied to the self-renewing pool of hepatocyte precursors in the adult liver). Hepatoblasts may also be endogenous, as some stem cells found in the liver come from the bone marrow via blood circulation."], "t": []}], "preferred_name": "hepatoblast", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5171669", "l": "Lymphocytes | Urine sediment | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Lymphocytes | Urine sediment | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5157552", "l": "CD4+CD45RO+ cells | Bone marrow | Cell markers", "d": [], "t": []}], "preferred_name": "CD4+CD45RO+ cells | Bone marrow | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C2337234", "l": "Suppressor enhancer T lymphocyte", "d": [], "t": []}], "preferred_name": "Suppressor enhancer T lymphocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "CL:0002401", "l": "mature dendritic epithelial T cell precursor", "d": ["A thymocyte that has a T cell receptor consisting of a gamma chain that has as part a Vgamma3 segment, and a delta chain. This cell type is CD4-negative, CD8-negative and CD24-negative. This cell-type is found in the fetal thymus with highest numbers occurring at E17-E18."], "t": []}], "preferred_name": "mature dendritic epithelial T cell precursor", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1183496", "l": "Neural plate cell", "d": [], "t": []}], "preferred_name": "Neural plate cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1955940", "l": "Common Lymphoid Progenitors", "d": [], "t": []}], "preferred_name": "Common Lymphoid Progenitors", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5986113", "l": "BRT-DA01", "d": [], "t": []}], "preferred_name": "BRT-DA01", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5785372", "l": "Autologous Engineered TCR-T Cells KSH01", "d": [], "t": []}, {"i": "NCIT:C192680", "l": "Autologous Engineered TCR-T Cells KSH01", "d": ["A preparation of autologous T-lymphocytes genetically modified to express a T-cell receptor (TCR) specific for an as of yet undisclosed tumor-associated antigen (TAA), with potential antineoplastic activity. Peripheral blood mononuclear cells (PBMCs) are isolated from a patient, transduced with a TCR specific for the TAA, and expanded ex-vivo. Upon reintroduction into the patient, the autologous engineered TCR-T cells KSH01 target and bind to tumor cells expressing the TAA, which may induce cell death in and halt the growth of cancer cells expressing the undisclosed TAA."], "t": []}], "preferred_name": "Autologous Engineered TCR-T Cells KSH01", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C2339291", "l": "Syncytial giant cell", "d": [], "t": []}], "preferred_name": "Syncytial giant cell", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "CL:0000431", "l": "iridophore", "d": ["A pigment cell derived from the neural crest. The cell contains flat light-reflecting platelets, probably of guanine, in stacks called reflecting platelets or iridisomes. The color-generating components produce a silver, gold, or iridescent color."], "t": []}], "preferred_name": "iridophore", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5761824", "l": "NY-ESO TCR therapeutic", "d": [], "t": []}], "preferred_name": "NY-ESO TCR therapeutic", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5706462", "l": "Autologous Anti-BCMA CAR T-cells MCARH125", "d": [], "t": []}, {"i": "NCIT:C188226", "l": "Autologous Anti-BCMA CAR T-cells MCARH125", "d": ["A preparation of autologous T-lymphocytes that have been genetically engineered to express a chimeric antigen receptor (CAR) targeting the human tumor-associated antigen (TAA) B-cell maturation antigen (BCMA; tumor necrosis factor receptor superfamily member 17; TNFRSF17), with potential antineoplastic activity. Upon administration, the autologous anti-BCMA CAR T-cells MCARH125 recognize and induce selective toxicity against BCMA-expressing tumor cells. BCMA, a tumor-specific antigen and a receptor for both a proliferation-inducing ligand (APRIL) and B-cell activating factor (BAFF), is a member of the tumor necrosis factor receptor superfamily (TNFRSF) and plays a key role in plasma cell survival. BCMA is found on the surfaces of plasma cells and is overexpressed on malignant plasma cells."], "t": []}], "preferred_name": "Autologous Anti-BCMA CAR T-cells MCARH125", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1979202", "l": "Blast cell positive for CD3 antigen", "d": [], "t": []}, {"i": "SNOMEDCT:724261003", "l": "", "d": [], "t": []}], "preferred_name": "Blast cell positive for CD3 antigen", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5157425", "l": "CD3 cells | Bone marrow | Cell markers", "d": [], "t": []}], "preferred_name": "CD3 cells | Bone marrow | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5448063", "l": "Autologous Anti-CD22 CAR-expressing T-cells SCRI-CAR22v2", "d": [], "t": []}, {"i": "NCIT:C176568", "l": "Autologous Anti-CD22 CAR-expressing T-cells SCRI-CAR22v2", "d": ["A preparation of autologous human T-lymphocytes that are genetically engineered to express a chimeric antigen receptor (CAR) targeting the tumor-associated antigen (TAA) CD22, with potential immunostimulating and antineoplastic activities. Upon administration, the autologous anti-CD22 CAR-expressing T-cells SCRI-CAR22v2 express anti-CD22-CAR on their cell surfaces and bind to the CD22 antigen on tumor cell surfaces leading to lysis of CD22-expressing B-cells. CD22, a B-lineage-restricted, transmembrane phosphoglycoprotein, is expressed on malignant B-cells."], "t": []}], "preferred_name": "Autologous Anti-CD22 CAR-expressing T-cells SCRI-CAR22v2", "taxa": []}
{"type": "biolink:Cell", "ic": 92.76600187037766, "identifiers": [{"i": "CL:0000581", "l": "peritoneal macrophage", "d": ["A macrophage resident in the peritoneum under non-inflammatory conditions. Markers include F4/80-high, CD11b-high, CD68-positive, SIGNR1-positive, CD115-high, MHC-II-negative, and Dectin-1-positive."], "t": []}, {"i": "UMLS:C0206190", "l": "Macrophages, Peritoneal", "d": [], "t": []}, {"i": "NCIT:C12566", "l": "Peritoneal Macrophage", "d": ["A differentiated macrophage that resides in the serosal peritoneal membrane and plays an important role in the defense against peritoneal cavity infections."], "t": []}, {"i": "MESH:D017737", "l": "Macrophages, Peritoneal", "d": [], "t": []}], "preferred_name": "peritoneal macrophage", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0333845", "l": "Polyploid plasmablast", "d": [], "t": []}, {"i": "SNOMEDCT:55093000", "l": "", "d": [], "t": []}], "preferred_name": "Polyploid plasmablast", "taxa": []}
{"type": "biolink:Cell", "ic": 86.30756602822301, "identifiers": [{"i": "CL:2000073", "l": "migratory cardiac neural crest cell", "d": ["Any migratory neural crest cell that is part of a cardiac neural crest."], "t": []}], "preferred_name": "migratory cardiac neural crest cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C2347347", "l": "Ad5F35-LMP1/LMP2-Transduced Autologous Dendritic Cells", "d": [], "t": []}, {"i": "NCIT:C73995", "l": "Ad5F35-LMP1/LMP2-Transduced Autologous Dendritic Cells", "d": ["Autologous dendritic cells (DCs) transduced with the replication-deficient adenoviral vector Ad5F53 encoding the Epstein-Barr virus (EBV) transmembrane latent membrane proteins 1 and 2 (LMP1/LMP2) with potential immunostimulatory activity. Vaccination with Ad5F35-LMP1/LMP2-transduced autologous dendritic cells may stimulate a specific cytotoxic T-lymphocyte (CTL) response against LMP1- and LMP2-expressing tumor positive cells, resulting in tumor cell lysis and inhibition of tumor cell proliferation. LMP1 and LMP2 are expressed in various malignancies including nasopharyngeal cancer and EBV-positive Hodgkins disease."], "t": []}], "preferred_name": "Ad5F35-LMP1/LMP2-Transduced Autologous Dendritic Cells", "taxa": []}
{"type": "biolink:Cell", "ic": 70.82453858732072, "identifiers": [{"i": "UMLS:C1514082", "l": "Neoplastic Sertoli Cell", "d": [], "t": []}, {"i": "NCIT:C36895", "l": "Neoplastic Sertoli Cell", "d": [], "t": []}], "preferred_name": "Neoplastic Sertoli Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0009015", "l": "Peyer's patch follicular dendritic cell", "d": ["A follicular dendritic cell located in the Peyer's patch. These cells from a meshwork in which Peyer's patch B cells reside."], "t": []}], "preferred_name": "Peyer's patch follicular dendritic cell", "taxa": []}
{"type": "biolink:Cell", "ic": 80.96785908349635, "identifiers": [{"i": "CL:0020005", "l": "spiral ligament fibrocyte", "d": ["An otic fibrocyte that is part of the spiral ligament. This cell is crucial in maintaining the endocochlear potential, regulating blood flow, participating in immune responses by secreting chemokines including MCP-1 and MIP-2, and producing extracellular matrix proteins such as collagen and cochlin."], "t": []}], "preferred_name": "spiral ligament fibrocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4307053", "l": "Astro-OLF NN_2 Slc25a34 astrocyte (Mmus)", "d": ["A astrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Aqp4 (Mmus), Hs3st3a1 (Mmus), Slc25a34 (Mmus), C4b (Mmus). It is distinguished from other Astro-OLF NN_2 cells by expression of Slc25a34, C4b. These cells are located in the Olfactory areas, brain , in or close to the regions: Main olfactory bulb, outer plexiform layer, Main olfactory bulb . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5233 Astro-OLF NN_2."], "t": []}], "preferred_name": "Astro-OLF NN_2 Slc25a34 astrocyte (Mmus)", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C2709167", "l": "Plateletpheresis half units", "d": [], "t": []}], "preferred_name": "Plateletpheresis half units", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4310083", "l": "GPin-BF cholinergic-GABAergic neuron (Primate)", "d": ["A GABA-Chol neuron of the Primates brain. These cells are located in the striatum, external segment of globus pallidus . Reference transcriptomic data for this type can be found in the dataset/taxonomy - HMBA Basal Ganglia Consensus Taxonomy in cell set Group:GPin-BF Cholinergic GABA."], "t": []}], "preferred_name": "GPin-BF cholinergic-GABAergic neuron (Primate)", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4253033", "l": "Epithelial cell of intraprostatic part of ejaculatory duct", "d": [], "t": []}], "preferred_name": "Epithelial cell of intraprostatic part of ejaculatory duct", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5157431", "l": "CD3+CD25+ cells | Bone marrow | Cell markers", "d": [], "t": []}], "preferred_name": "CD3+CD25+ cells | Bone marrow | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1513301", "l": "Mikulicz Cell", "d": [], "t": []}, {"i": "NCIT:C36738", "l": "Mikulicz Cell", "d": [], "t": []}], "preferred_name": "Mikulicz Cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1440359", "l": "CD80+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:1372934008", "l": "", "d": [], "t": []}], "preferred_name": "CD80+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1440304", "l": "CD4+CD69+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:1373111006", "l": "", "d": [], "t": []}], "preferred_name": "CD4+CD69+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1440273", "l": "CD19+CD22+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:1372976000", "l": "", "d": [], "t": []}], "preferred_name": "CD19+CD22+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": 90.871710685482, "identifiers": [{"i": "CL:1001586", "l": "mammary gland glandular cell", "d": ["Glandular cell of mammary epithelium. Example: glandular cells of large and intermediate ducts, glandular cells in terminal ducts."], "t": []}], "preferred_name": "mammary gland glandular cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C2826113", "l": "M87o-Transduced CD34+ Peripheral Blood Stem Cells", "d": [], "t": []}, {"i": "NCIT:C82351", "l": "M87o-Transduced CD34+ Peripheral Blood Stem Cells", "d": ["Peripheral blood stem cells (PBSCs) transduced with the retroviral vector M87o encoding for the HIV-1-entry inhibitor peptide membrane-anchored antiviral peptide C46 (maC46). Expression of C46 by M87o-transduced CD34+ peripheral blood stem cells may prevent the fusion of viral and cellular membranes, thereby inhibiting HIV-1 entry. C46 is a membrane-anchored peptide encoding amino acids 628 to 673 of the HIV-1 entry inhibitory transmembrane glycoprotein gp41."], "t": []}], "preferred_name": "M87o-Transduced CD34+ Peripheral Blood Stem Cells", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5157597", "l": "CD5+CD2- | White blood cells | Cell markers", "d": [], "t": []}], "preferred_name": "CD5+CD2- | White blood cells | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C2599885", "l": "Immature neutrophils", "d": [], "t": []}, {"i": "SNOMEDCT:570111010000102", "l": "", "d": [], "t": []}], "preferred_name": "Immature neutrophils", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5420490", "l": "CD123-CD33 Compound CAR T Cells", "d": [], "t": []}, {"i": "NCIT:C173970", "l": "CD123-CD33 Compound CAR T Cells", "d": ["A preparation of T-lymphocytes transduced with a lentiviral vector expressing a compound chimeric antigen receptor (cCAR) containing two distinct units of CARs, one specific for the CD123 (interleukin-3 receptor alpha chain or IL3RA) antigen and one specific for the CD33 antigen, with potential immunomodulating and antineoplastic activities. Upon administration, the CD123-CD33 cCAR T cells specifically and simultaneously target and bind to tumor cells expressing CD123 and/or CD33. This induces selective toxicity in tumor cells that express the CD123 antigen and/or the CD33 antigen. CD123 is normally expressed on committed blood progenitor cells in the bone marrow; its overexpression is associated with increased leukemic cell proliferation and aggressiveness. CD33 is expressed on normal non-pluripotent hematopoietic stem cells and is overexpressed on myeloid leukemia cells. Targeting two different antigens may improve coverage and protect against antigen escape and relapse as it is less likely for tumor cells to lose both antigens. Additionally, the CD123-CD33 cCAR T cells express CD52 on the cell surface. This allows the depletion of the CD123-CD33 cCAR T cells with the administration of the anti-CD52 monoclonal antibody alemtuzumab, in case of unacceptable side effects."], "t": []}], "preferred_name": "CD123-CD33 Compound CAR T Cells", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0000684", "l": "littoral cell of liver", "d": [], "t": []}], "preferred_name": "littoral cell of liver", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0001077", "l": "ILC1, human", "d": ["An ILC1 cell in the human with the phenotype CD56-negative, IL-7Ralpha-positive, T-bet-positive."], "t": []}], "preferred_name": "ILC1, human", "taxa": []}
{"type": "biolink:Cell", "ic": 77.38833137893549, "identifiers": [{"i": "CL:0002148", "l": "dental pulp cell", "d": ["A cell found within the dental pulp."], "t": []}, {"i": "UMLS:C1519550", "l": "Dental pulp cell", "d": [], "t": []}, {"i": "NCIT:C33793", "l": "Tooth Cell", "d": ["The cell of the tooth. It includes the odontoblast, cementoblast, cementocyte, and ameloblast."], "t": []}], "preferred_name": "dental pulp cell", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "CL:0000132", "l": "corneal endothelial cell", "d": ["An hexagonal, flattened, mitochondria-rich endothelial cell that forms a monolayer on the posterior surface of the cornea (the corneal endothelium). Corneal endothelial cells are derived from the neural crest and are responsible for keeping the cornea transparent by maintaining the tissue in a semi-dry state through the action of their ionic pumps and tight junction barrier."], "t": []}, {"i": "UMLS:C1182654", "l": "Corneal endothelial cell", "d": [], "t": []}], "preferred_name": "corneal endothelial cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1514890", "l": "Reserve Cell", "d": [], "t": []}, {"i": "NCIT:C33916", "l": "Reserve Cell", "d": ["A term that refers to immature cells located between the surface columnar epithelium and the basal layer."], "t": []}], "preferred_name": "Reserve Cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4322675", "l": "CD8+CD38+ T lymphocyte", "d": [], "t": []}], "preferred_name": "CD8+CD38+ T lymphocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1516091", "l": "Atypical Ductal Epithelial Cell", "d": [], "t": []}, {"i": "NCIT:C36883", "l": "Atypical Ductal Epithelial Cell", "d": [], "t": []}], "preferred_name": "Atypical Ductal Epithelial Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 56.76063651843069, "identifiers": [{"i": "UMLS:C0018956", "l": "Hematopoietic stem cells", "d": [], "t": []}, {"i": "NCIT:C12551", "l": "Hematopoietic Stem Cell", "d": ["Primitive blood cells derived from embryonic mesenchyme capable of differentiating into any of the blood cell line progenitor cells (erythroblasts, young granulocytic series cells, megakaryocytes, etc.)"], "t": []}, {"i": "MESH:D006412", "l": "Hematopoietic Stem Cells", "d": [], "t": []}, {"i": "SNOMEDCT:418318001", "l": "", "d": [], "t": []}], "preferred_name": "Hematopoietic stem cells", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1525454", "l": "CD2+CD3+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:1372990002", "l": "", "d": [], "t": []}], "preferred_name": "CD2+CD3+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5216236", "l": "Leukocytes|NCnc|Pt|Gast fld", "d": [], "t": []}], "preferred_name": "Leukocytes|NCnc|Pt|Gast fld", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C3653189", "l": "Alipogene tiparvovec", "d": [], "t": []}, {"i": "NCIT:C166528", "l": "Alipogene Tiparvovec", "d": [], "t": []}, {"i": "MESH:C000721108", "l": "Alipogene tiparvovec", "d": [], "t": []}], "preferred_name": "Alipogene tiparvovec", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5173430", "l": "Monocytes | Blood | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Monocytes | Blood | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": 60.59776109481737, "identifiers": [{"i": "CL:0000789", "l": "alpha-beta T cell", "d": ["A T cell that expresses an alpha-beta T cell receptor complex."], "t": []}], "preferred_name": "alpha-beta T cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C4727621", "l": "Autologous NY-ESO-1 TCR-targeted T Lymphocytes", "d": [], "t": []}, {"i": "NCIT:C148150", "l": "Autologous NY-ESO-1 TCR-targeted T Lymphocytes", "d": ["A preparation of human autologous T-lymphocytes that are transduced with a gene encoding a T-cell receptor (TCR) specific for the cancer-testis antigen NY-ESO-1, with potential immunostimulating and antineoplastic activities. Upon isolation, transduction, expansion ex vivo, and reintroduction into the patient, the anti-NY-ESO-1 TCR-transduced autologous T-cells recognize and bind to NY-ESO-1-overexpressing tumor cells. This may result in a specific cytotoxic T-lymphocyte (CTL)-mediated killing of NY-ESO-1-positive tumor cells. NY-ESO-1, a tumor-associated antigen (TAA), is found in normal testis and on the surface of various tumor cell types, and is not, or is minimally, expressed in normal, healthy cells."], "t": []}], "preferred_name": "Autologous NY-ESO-1 TCR-targeted T Lymphocytes", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5557607", "l": "Autologous anti-CD20/CD19-targeting tandem CAR T cells MB-CART2019.1", "d": [], "t": []}], "preferred_name": "Autologous anti-CD20/CD19-targeting tandem CAR T cells MB-CART2019.1", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4307049", "l": "Astro-TE NN_5 Hs3st3a1 astrocyte (Mmus)", "d": ["A astrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of S1pr1 (Mmus), Thbs4 (Mmus), Hs3st3a1 (Mmus), Sfrp1 (Mmus). It is distinguished from other Astro-TE NN_5 cells by expression of Hs3st3a1, Sfrp1. These cells are located in the Olfactory areas, brain , in or close to the regions: Anterior olfactory nucleus, corpus callosum, body, lateral ventricle, corpus callosum, anterior forceps . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5229 Astro-TE NN_5."], "t": []}], "preferred_name": "Astro-TE NN_5 Hs3st3a1 astrocyte (Mmus)", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4040000", "l": "glial restricted tripotential precursor cell", "d": ["A glial precursor cell that generates oligodendrocytes and type-1 and type-2 astrocytes. It has been shown in some mammals that this cell type may express A2B5, nestin, FGFR-1, FGFR-2, FGFR-3, PLP, and DM-20 antigens. Unlike oligodendrocyte precursor cell, it does not initially express PDGFR-alpha and can differentiate into both type-1 and type-2 astrocytes."], "t": []}], "preferred_name": "glial restricted tripotential precursor cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4042840", "l": "RAW 264.7 Cells", "d": [], "t": []}, {"i": "MESH:D000067996", "l": "RAW 264.7 Cells", "d": [], "t": []}], "preferred_name": "RAW 264.7 Cells", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1148382", "l": "Monocytes+Macrophages", "d": [], "t": []}], "preferred_name": "Monocytes+Macrophages", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5173063", "l": "Micromegakaryocytes | Blood | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Micromegakaryocytes | Blood | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5171869", "l": "Macrophages | Pleural fluid | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Macrophages | Pleural fluid | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0002234", "l": "basal cell of prostatic acinus", "d": ["A cell of the basal layer of the epithelium in the prostatic acinus."], "t": []}, {"i": "UMLS:C1183931", "l": "Basal cell of prostatic acinus", "d": [], "t": []}], "preferred_name": "basal cell of prostatic acinus", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1267953", "l": "Lymphocyte positive for CD62E antigen", "d": [], "t": []}, {"i": "SNOMEDCT:117394000", "l": "", "d": [], "t": []}], "preferred_name": "Lymphocyte positive for CD62E antigen", "taxa": []}
{"type": "biolink:Cell", "ic": 81.34422831136257, "identifiers": [{"i": "CL:0002098", "l": "regular cardiac myocyte", "d": ["A cardiac myocyte that is connected to other cardiac myocytes by transverse intercalated discs (GO:0014704) at a regular interval."], "t": []}, {"i": "UMLS:C1180382", "l": "Regular cardiac myocyte", "d": [], "t": []}], "preferred_name": "regular cardiac myocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C4763553", "l": "Allogeneic CMV Antigen-specific CD4+/CD8+ T-lymphocytes", "d": [], "t": []}, {"i": "NCIT:C157340", "l": "Allogeneic CMV Antigen-specific CD4+/CD8+ T-lymphocytes", "d": ["A population of allogeneic T-lymphocytes specifically reactive to cytomegalovirus (CMV) with potential antiviral activity. Allogeneic CMV antigen-specific T-cells are prepared via ex vivo stimulation of donor-derived peripheral blood mononuclear cells (PBMCs) with major cytomegalovirus structural protein, pp65 (ppUL83). T-cells that secrete interferon (IFN)-gamma in response to pp65 antigen exposure are selected and expanded for administration. Administration of the CMV antigen-specific CD4+ and CD8+T-lymphocytes into hematopoietic stem cell transplant (HSCT) or immunocompromised patients infected with CMV may potentially reconstitute virus-specific responses, thereby controlling CMV infections."], "t": []}], "preferred_name": "Allogeneic CMV Antigen-specific CD4+/CD8+ T-lymphocytes", "taxa": []}
{"type": "biolink:Cell", "ic": 86.30756602822301, "identifiers": [{"i": "CL:1000481", "l": "transitional myocyte of atrioventricular bundle", "d": ["A transitional myocyte that is part of the atrioventricular bundle."], "t": []}, {"i": "UMLS:C2329763", "l": "Transitional myocyte of atrioventricular bundle", "d": [], "t": []}], "preferred_name": "transitional myocyte of atrioventricular bundle", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1519129", "l": "SBIL-2 Transduced Autologous Tumor-Infiltrating Lymphocyte", "d": [], "t": []}, {"i": "NCIT:C38118", "l": "SBIL-2 Transduced Autologous Tumor-Infiltrating Lymphocyte", "d": ["A population of tumor-infiltrating lymphocytes (TILs) harvested from a patient and transduced with a retroviral vector encoding the gene for interleukin-2 (IL-2).  TILs require IL-2 to sustain them when they are transferred back to the patient.  By inserting the IL-2 gene into TILs in vitro so that TILs express IL-2 continuously it is possible to provide TIL-sustaining IL-2 in vivo specifically at the site of lymphocyte infiltration, thereby avoiding the toxicity associated with the systemic administration of IL-2. (NCI04)"], "t": []}], "preferred_name": "SBIL-2 Transduced Autologous Tumor-Infiltrating Lymphocyte", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C2350243", "l": "Granulocyte-Macrophage Progenitor Cells", "d": [], "t": []}, {"i": "MESH:D055014", "l": "Granulocyte-Macrophage Progenitor Cells", "d": [], "t": []}], "preferred_name": "Granulocyte-Macrophage Progenitor Cells", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0007013", "l": "terminally differentiated odontoblast", "d": ["Odontoblast that is terminally differentiated and derived from an odontogenic papilla and associated with dentine."], "t": []}], "preferred_name": "terminally differentiated odontoblast", "taxa": []}
{"type": "biolink:Cell", "ic": 61.31552654470323, "identifiers": [{"i": "CL:4033050", "l": "catecholaminergic neuron", "d": ["A neuron that releases catecholamine as a neurotransmitter."], "t": []}], "preferred_name": "catecholaminergic neuron", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5206457", "l": "Engineered Human Umbilical Vein Endothelial Cells AB-205", "d": [], "t": []}, {"i": "NCIT:C162248", "l": "Engineered Human Umbilical Vein Endothelial Cells AB-205", "d": ["A population of ex vivo expanded, genetically engineered CD31 (platelet endothelial cell adhesion molecule; PECAM-1)-positive human umbilical vein endothelial cells (HUVECs) derived from human umbilical vein tissue, that can be used to enhance the hematopoietic stem and progenitor cells (HSPCs) transplantation potential and improve blood cell recovery. Following autologous stem cell transplantation (ASCT) and upon the administration of the engineered HUVEC AB-205, the endothelial cells secrete angiocrine growth factors and interact with the HSPCs, thereby forming endothelial cell network structures and improving engraftment potential. AB-205 also interacts with injured or damaged vascular niche cells, thereby promoting blood cell recovery and improving tissue regeneration. This enhances recovery from toxicities related to chemo/radiation regimens."], "t": []}], "preferred_name": "Engineered Human Umbilical Vein Endothelial Cells AB-205", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C3640942", "l": "Recombinant Human MUC1-Oxidized Polymannose-pulsed Autologous Dendritic Cell Vaccine", "d": [], "t": []}, {"i": "NCIT:C102782", "l": "Recombinant Human MUC1-Oxidized Polymannose-pulsed Autologous Dendritic Cell Vaccine", "d": ["A cancer vaccine containing autologous dendritic cells pulsed with a fusion product of an epitope of human tumor-associated epithelial mucin 1 (MUC1) antigen and the vaccine adjuvant mannan (oxidized mannose), with potential antineoplastic activity. When the modified dendritic cells are returned to the patient, they may stimulate the host immune system to mount a cytotoxic T lymphocyte (CTL) response against tumor cells positive for the MUC1 antigen, resulting in tumor cell lysis. Addition of manna in this vaccine, enhances immune recognition. MUC1 antigen, a high-molecular-weight transmembrane glycoprotein, is overexpressed on many tumor cells."], "t": []}], "preferred_name": "Recombinant Human MUC1-Oxidized Polymannose-pulsed Autologous Dendritic Cell Vaccine", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5783406", "l": "Varnimcabtagene Autoleucel", "d": [], "t": []}], "preferred_name": "Varnimcabtagene Autoleucel", "taxa": []}
{"type": "biolink:Cell", "ic": 82.16838616155795, "identifiers": [{"i": "UMLS:C5700103", "l": "Doughnut Cell", "d": [], "t": []}, {"i": "NCIT:C39680", "l": "Doughnut Cell", "d": [], "t": []}], "preferred_name": "Doughnut Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4033014", "l": "peg cell", "d": ["A small, narrow, peg-shaped epithelial cell with little cytoplasm that is part of oviduct epithelium. This cell is rarer than the ciliated and secretory epithelial cells of the fallopian tube epithelium and is often found intercalated between them. Peg cells are generally distributed basally along the epithelium and have been found in high concentrations at the fimbriated, distal end of the fallopian tube in humans. It may have a regenerative/stem-cell function. In humans, markers include EPCAM, CD44, and ITGA6."], "t": []}], "preferred_name": "peg cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4072022", "l": "Lamp5 Lhx6 GABAergic interneuron (Homo sapiens)", "d": ["A Lamp5 Lhx6 GABAergic interneuron of Homo sapiens. The standard transcriptomic reference data for this cell type can be found on the CellxGene census under the collection: 'Transcriptomic cytoarchitecture reveals principles of human neocortex organization', dataset: 'Supercluster: CGE-derived interneurons', Author Categories: 'CrossArea_subclass', Lamp5 Lhx6"], "t": []}], "preferred_name": "Lamp5 Lhx6 GABAergic interneuron (Homo sapiens)", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5172510", "l": "Mesothelial cells | XXX | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Mesothelial cells | XXX | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5985175", "l": "Autologous Anti-ALK CAR T-cells", "d": [], "t": []}, {"i": "NCIT:C213795", "l": "Autologous Anti-ALK CAR T-cells", "d": ["A preparation of autologous T-lymphocytes that have been genetically engineered to express a chimeric antigen receptor (CAR) targeting the human receptor tyrosine kinase (RTK) anaplastic lymphoma kinase (ALK), with potential immunostimulating and antineoplastic activities. Upon administration, autologous anti-ALK CAR T-cell recognize and induce selective toxicity against ALK-expressing tumor cells. ALK belongs to the insulin receptor superfamily and plays an important role in nervous system development. ALK is not expressed in healthy adult human tissue but ALK dysregulation and gene rearrangements are associated with a variety of tumor cell types."], "t": []}], "preferred_name": "Autologous Anti-ALK CAR T-cells", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C2338142", "l": "Non-nucleated colligocyte", "d": [], "t": []}], "preferred_name": "Non-nucleated colligocyte", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4510884", "l": "Blast cell positive for CD11c antigen", "d": [], "t": []}, {"i": "SNOMEDCT:724308009", "l": "", "d": [], "t": []}], "preferred_name": "Blast cell positive for CD11c antigen", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5426633", "l": "CD3-CD14+CD45+DOCK8+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:1373231000", "l": "", "d": [], "t": []}], "preferred_name": "CD3-CD14+CD45+DOCK8+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0946499", "l": "CD4+CD29+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:1373108005", "l": "", "d": [], "t": []}], "preferred_name": "CD4+CD29+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C6065169", "l": "AB-207", "d": [], "t": []}], "preferred_name": "AB-207", "taxa": []}
{"type": "biolink:Cell", "ic": 68.8717166271425, "identifiers": [{"i": "CL:0002632", "l": "epithelial cell of lower respiratory tract", "d": ["Any epithelial cell that is part of some lower respiratory tract epithelium."], "t": []}], "preferred_name": "epithelial cell of lower respiratory tract", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C6022653", "l": "Autologous Anti-Claudin18.2-transduced T Lymphocytes CT041", "d": [], "t": []}], "preferred_name": "Autologous Anti-Claudin18.2-transduced T Lymphocytes CT041", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5552636", "l": "Anti-p53 T-Cell Receptor-Transduced Peripheral Blood Lymphocytes", "d": [], "t": []}, {"i": "NCIT:C64773", "l": "Anti-p53 T-Cell Receptor-Transduced Peripheral Blood Lymphocytes", "d": ["Human autologous peripheral blood lymphocytes (PBLs) transduced with an anti-p53 T cell receptor gene with potential antineoplastic activity. PBLs are harvested from a patient and pulsed with a retroviral vector that encodes the T-cell receptor gene specific for a mutated form of p53. The transduced PBLs are then expanded in culture. When reintroduced to the patient, these modified PBLs express the anti-p53 T cell receptor which binds to mutant p53-overexpressing tumor cells; PBL-mediated tumor growth inhibition may follow. Many tumor cell types overexpress mutant p53 proteins, which are associated with the loss of apoptosis regulation and abnormal cell proliferation."], "t": []}], "preferred_name": "Anti-p53 T-Cell Receptor-Transduced Peripheral Blood Lymphocytes", "taxa": []}
{"type": "biolink:Cell", "ic": 80.27409497666227, "identifiers": [{"i": "CL:0000914", "l": "immature NK T cell", "d": ["An immature alpha-beta T-cell that express Egr2. These cells give rise to T cells expressing NK markers."], "t": []}], "preferred_name": "immature NK T cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4033063", "l": "endovascular extravillous trophoblast cell", "d": ["A trophoblast cell that invades the maternal spiral arteries and replace the endothelial lining, remodeling the vessels and allowing for adequate blood transport into the placenta. An endovascular extravillous trophoblast cell differentiates from an extravillous trophoblast cell. In humans, this cell can be distinguished by the expression of CD56."], "t": []}], "preferred_name": "endovascular extravillous trophoblast cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4322737", "l": "CD1+ T lymphocyte", "d": [], "t": []}], "preferred_name": "CD1+ T lymphocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 92.76600187037766, "identifiers": [{"i": "CL:1000325", "l": "jejunal goblet cell", "d": ["A goblet cell that is part of the epithelium proper of jejunum."], "t": []}], "preferred_name": "jejunal goblet cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C4726578", "l": "Autologous Anti-Muc1/CD33/CD38/CD56/CD123 Gene-engineered CAR-T Cells", "d": [], "t": []}, {"i": "NCIT:C151954", "l": "Autologous Anti-Muc1/CD33/CD38/CD56/CD123 Gene-engineered CAR-T Cells", "d": ["A preparation of genetically modified autologous T-cells transduced with lentiviral vectors expressing chimeric antigen receptors (CARs) specific for the tumor-associated antigens (TAAs) mucin 1 (Muc1; MUC1), cluster of differentiation 33 (CD33), CD38, CD56 and CD123 (interleukin-3 receptor alpha chain or IL3RA), with potential immunostimulating and antineoplastic activities. Upon intravenous administration, autologous anti-Muc1/CD33/CD38/CD56/CD123 gene-engineered CAR-T cells are directed to and induce selective toxicity in Muc1/CD33/CD38/CD56/CD123-expressing tumor cells. Muc1/CD33/CD38/CD56/CD123 are present on certain tumor cell types and are minimally expressed on normal, healthy cells. Expression of these TAAs are correlated with poor prognosis. CD28, CD137 and CD27, T-cell surface-associated co-stimulatory molecules included in the CARs, are required for full T-cell activation and enhance both proliferation of T-cells and antitumor activity."], "t": []}], "preferred_name": "Autologous Anti-Muc1/CD33/CD38/CD56/CD123 Gene-engineered CAR-T Cells", "taxa": []}
{"type": "biolink:Cell", "ic": 89.40238429118027, "identifiers": [{"i": "CL:0000846", "l": "vestibular dark cell", "d": ["An epithelial cell of the vestibular sensory organ that is characterized by intense enzymatic activities and numerous basal membrane infoldings."], "t": []}], "preferred_name": "vestibular dark cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0020055", "l": "calretinin-positive intrinsic primary afferent neuron of myenteric plexus", "d": ["An intrinsic primary afferent neuron of the myenteric plexus that is immunopositive for calretinin. This neuron shares the Dogiel type II morphology and AH-type electrophysiology of all myenteric IPANs, and is immunopositive for choline acetyltransferase (ChAT) and immunonegative for neuronal nitric oxide synthase (NOS1)."], "t": []}], "preferred_name": "calretinin-positive intrinsic primary afferent neuron of myenteric plexus", "taxa": []}
{"type": "biolink:Cell", "ic": 90.871710685482, "identifiers": [{"i": "CL:0002461", "l": "CD103-positive dendritic cell", "d": ["A conventional dendritic cell that is CD103-positive. This cell type is usually found in non-lymphoid tissue."], "t": []}], "preferred_name": "CD103-positive dendritic cell", "taxa": []}
{"type": "biolink:Cell", "ic": 92.76600187037766, "identifiers": [{"i": "CL:0002323", "l": "amniocyte", "d": ["A cell of a fetus which is suspended in the amniotic fluid. Amniocytes are considered to arise from several tissues including fetal skin, the fetal urinary tract, umbilical cord, and the inner amniotic surface."], "t": []}], "preferred_name": "amniocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C2981181", "l": "Autologous PBTL CD19CAR-28 zeta", "d": [], "t": []}, {"i": "NCIT:C78823", "l": "Autologous PBTL CD19CAR-28 zeta", "d": ["A preparation of autologous peripheral blood T-lymphocytes (PBTL) that have been genetically modified to express the chimeric antigen receptor (CAR) anti-CD19/CD3 zeta chain fusion protein coupled to the intracellular signal domain of CD28 antigen, with potential immunostimulating and antineoplastic activities. Upon administration, autologous PBTL CD19CAR-28 zeta may stimulate host cytotoxic T lymphocyte (CTL) and antibody responses against CD19-expressing tumor cells, resulting in tumor cell lysis. CD19 antigen is a B-cell specific cell surface antigen expressed in all B-cell lineage malignancies. CD3 zeta is one of several membrane-bound polypeptides found in the T-cell receptor (TCR)/CD3 complex and regulates the assembly of complete TCR complexes and their expression on the cell surface. CD28 is essential for CD4+ T-cell proliferation, interleukin-2 production, and T-helper type-2 (Th2) development."], "t": []}], "preferred_name": "Autologous PBTL CD19CAR-28 zeta", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0002474", "l": "lymphoid MHC-II-negative classical monocyte", "d": ["A MHC-II-negative classical monocyte located in lymphoid tissue that is F4/80-positive, CD11c-negative, and CD11b-high."], "t": []}], "preferred_name": "lymphoid MHC-II-negative classical monocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 65.95407503160773, "identifiers": [{"i": "CL:0000339", "l": "glioblast (sensu Vertebrata)", "d": ["An early neural cell developing from the early ependymal cell of the neural tube."], "t": []}], "preferred_name": "glioblast (sensu Vertebrata)", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1979673", "l": "Cells.CD4+CD7-CD26-", "d": [], "t": []}], "preferred_name": "Cells.CD4+CD7-CD26-", "taxa": []}
{"type": "biolink:Cell", "ic": 79.35380886648232, "identifiers": [{"i": "CL:4047017", "l": "transit amplifying cell of gut", "d": ["A transit amplifying cell of the gut epithelium, located in the wall of the intestinal crypt, just above intestinal stem cells from which they derive. These are rapidly dividing cells, capable of multiple rounds of division before differentiating into the various cell types of the gut epithelium (enterocyte, goblet, eneterodendocrine, paneth cells)."], "t": []}], "preferred_name": "transit amplifying cell of gut", "taxa": []}
{"type": "biolink:Cell", "ic": 78.29800561113302, "identifiers": [{"i": "UMLS:C1518228", "l": "Malignant Oncocyte", "d": [], "t": []}, {"i": "NCIT:C36942", "l": "Malignant Oncocyte", "d": ["A malignant epithelial cell with abundant eosinophilic or clear granular cytoplasm."], "t": []}], "preferred_name": "Malignant Oncocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C0018873", "l": "HeLa Cells", "d": [], "t": []}, {"i": "NCIT:C20226", "l": "HeLa", "d": ["HeLa cells were developed from cervix adenocarcinoma of a 31-year-old Black female. The cells are positive for keratin by immunoperoxidase staining. HeLa cells have been reported to contain human papilloma virus 18 (HPV-18) sequences.  P53 expression was reported to be low, and normal levels of pRB (retinoblastoma suppressor) were found. Four typical HeLa marker chromosomes have been reported.  M1 is a rearranged long arm and centromere of chromosome 1 and the long arm of chromosome 3. M2 is a combination of short arm of chromosome 3 and long arm of chromosome 5.  M3 is an isochromosome of the short arm of chromosome 5. M4 consists of the long arm of chromosome 11 and an arm of chromosome 19. HeLa Marker Chromosomes: One copy of Ml, one copy of M2, four-five copies of M3, and two copies of M4 as revealed by G-banding patterns."], "t": []}, {"i": "MESH:D006367", "l": "HeLa Cells", "d": [], "t": []}], "preferred_name": "HeLa Cells", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4033172", "l": "pelvic ganglion NPY/VAChT neuron", "d": ["A parasympathetic neuron that has the soma located in the pelvic ganglion and expresses the marker neuropeptide Y (NPY) and vesicular acetylcholine transporter (VAChT)."], "t": []}], "preferred_name": "pelvic ganglion NPY/VAChT neuron", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4512518", "l": "Entire infantile diploetic mastoid cell", "d": [], "t": []}, {"i": "SNOMEDCT:727281006", "l": "", "d": [], "t": []}], "preferred_name": "Entire infantile diploetic mastoid cell", "taxa": []}
{"type": "biolink:Cell", "ic": 92.76600187037766, "identifiers": [{"i": "CL:0000353", "l": "blastoderm cell", "d": ["An undifferentiated cell produced by early cleavages of the fertilized egg (zygote)."], "t": []}, {"i": "UMLS:C0005712", "l": "Structure of blastomere", "d": [], "t": []}, {"i": "NCIT:C12518", "l": "Blastomere", "d": ["A cell formed by cleavage division during embryogenesis."], "t": []}, {"i": "MESH:D001757", "l": "Blastomeres", "d": [], "t": []}, {"i": "SNOMEDCT:296383004", "l": "", "d": [], "t": []}, {"i": "SNOMEDCT:367618007", "l": "", "d": [], "t": []}], "preferred_name": "blastoderm cell", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "CL:0002673", "l": "tongue muscle cell", "d": ["A skeletal muscle cell that is part of the tongue."], "t": []}], "preferred_name": "tongue muscle cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C6064637", "l": "CD38+HLA-DR+", "d": [], "t": []}, {"i": "SNOMEDCT:1384203007", "l": "", "d": [], "t": []}], "preferred_name": "CD38+HLA-DR+", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5205480", "l": "Autologous Anti-BCMA CAR T-cells IM21", "d": [], "t": []}, {"i": "NCIT:C160704", "l": "Autologous Anti-BCMA CAR T-cells IM21", "d": ["A preparation of autologous T-lymphocytes that have been transduced with a lentiviral vector (LV) expressing a chimeric antigen receptor (CAR) targeting the human tumor-associated antigen (TAA) B-cell maturation antigen (BCMA; tumor necrosis factor receptor superfamily member 17; TNFRSF17) and containing, as of yet undisclosed costimulatory signaling domains, with potential antineoplastic activity. Upon administration, the autologous anti-BCMA CAR T-cells IM21 recognize and induce selective toxicity against BCMA-expressing tumor cells. BCMA, a tumor-specific antigen and a receptor for both a proliferation-inducing ligand (APRIL) and B-cell activating factor (BAFF), is a member of the tumor necrosis factor receptor superfamily (TNFRSF) and plays a key role in plasma cell survival. BCMA is found on the surfaces of plasma cells and is overexpressed on malignant plasma cells."], "t": []}], "preferred_name": "Autologous Anti-BCMA CAR T-cells IM21", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0882937", "l": "Cell positive for CD8 antigen and CD57 antigen", "d": [], "t": []}, {"i": "SNOMEDCT:1373069002", "l": "", "d": [], "t": []}], "preferred_name": "Cell positive for CD8 antigen and CD57 antigen", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5216278", "l": "Mononuclear cells|NCnc|Pt|Body fld", "d": [], "t": []}], "preferred_name": "Mononuclear cells|NCnc|Pt|Body fld", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C2350827", "l": "Ciliary Photoreceptor Cells", "d": [], "t": []}], "preferred_name": "Ciliary Photoreceptor Cells", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0949432", "l": "TC2 Cells", "d": [], "t": []}], "preferred_name": "TC2 Cells", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:2000006", "l": "tonsil germinal center B cell", "d": ["Any germinal center B cell that is part of a tonsil."], "t": []}], "preferred_name": "tonsil germinal center B cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0229423", "l": "Mastoid cells", "d": [], "t": []}, {"i": "SNOMEDCT:57222008", "l": "", "d": [], "t": []}], "preferred_name": "Mastoid cells", "taxa": []}
{"type": "biolink:Cell", "ic": 88.20185721311867, "identifiers": [{"i": "UMLS:C1708887", "l": "Malignant Large Squamous Cell", "d": [], "t": []}, {"i": "NCIT:C54235", "l": "Malignant Large Squamous Cell", "d": [], "t": []}], "preferred_name": "Malignant Large Squamous Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:2000045", "l": "foreskin melanocyte", "d": ["Any melanocyte of skin that is part of a skin of prepuce of penis."], "t": []}], "preferred_name": "foreskin melanocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C3273000", "l": "Allogeneic CD56-positive CD3-negative Natural Killer Cells", "d": [], "t": []}, {"i": "NCIT:C96741", "l": "Allogeneic CD56-positive CD3-negative Natural Killer Cells", "d": ["A population of allogeneic lymphocytes expressing the CD56 surface antigen and exhibiting a lack of CD3, with immunomodulating activity. Upon infusion of allogeneic CD56-positive CD3-negative natural killer (NK) cells, these cells are able to secrete cytokines and recognize and kill tumor cells as well as virally-infected cells. CD56 is a transmembrane glycoprotein also known as NCAM (Neural Cell Adhesion Molecule)."], "t": []}], "preferred_name": "Allogeneic CD56-positive CD3-negative Natural Killer Cells", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4047011", "l": "fetal vein endothelial cell", "d": ["An endothelial cell that lines the veins in the fetal circulatory system."], "t": []}], "preferred_name": "fetal vein endothelial cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C3640056", "l": "CD19CAR-CD3zeta-4-1BB-expressing Allogeneic T-lymphocyte Cells", "d": [], "t": []}, {"i": "NCIT:C101258", "l": "CD19CAR-CD3zeta-4-1BB-expressing Allogeneic T-lymphocyte Cells", "d": ["Allogeneic T-lymphocytes transduced with a modified lentiviral vector expressing a chimeric antigen receptor (CAR) consisting of an anti-CD19 scFv (single chain variable fragment) and the zeta chain of the TCR/CD3 complex (CD3-zeta), coupled to the signaling domain of 4-1BB (CD137), with potential immunomodulating and antineoplastic activities. Upon transfusion, CD19CAR-CD3zeta-4-1BB-expressing allogeneic T-lymphocyte cells direct the T-lymphocytes to CD19-expressing tumor cells, thereby inducing a selective toxicity in CD19-expressing tumor cells. The 4-1BB co-stimulatory molecule signaling domain enhances activation and signaling after recognition of CD19 and the inclusion of this signaling domain may increase the antitumor activity compared to the inclusion of the CD3-zeta chain alone. CD19 antigen is a B-cell specific cell surface antigen expressed in all B-cell lineage malignancies."], "t": []}], "preferred_name": "CD19CAR-CD3zeta-4-1BB-expressing Allogeneic T-lymphocyte Cells", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1512337", "l": "HeLa/SF", "d": [], "t": []}, {"i": "NCIT:C20228", "l": "HeLa/SF", "d": ["HeLa/SF is a derivative of HeLa adapted to grow in serum free medium. Over time, the serum component of the medium was replaced with TCH, a defined multipurpose serum replacement."], "t": []}], "preferred_name": "HeLa/SF", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5419241", "l": "Rexlemestrocel-L", "d": [], "t": []}, {"i": "NCIT:C171655", "l": "Rexlemestrocel-L", "d": [], "t": []}], "preferred_name": "Rexlemestrocel-L", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4052032", "l": "granzyme H-associated CD8 T cell", "d": ["A CD8 T cell characterized by high expression of Granzyme H (GZMH). This cell exhibits a restricted TCR repertoire and elevated expression of cytotoxic, exhaustion, and type I interferon-stimulated gene signatures compared to controls."], "t": []}], "preferred_name": "granzyme H-associated CD8 T cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0228075", "l": "Small neuron", "d": [], "t": []}, {"i": "SNOMEDCT:16868009", "l": "", "d": [], "t": []}], "preferred_name": "Small neuron", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:1001582", "l": "lateral ventricle neuron", "d": ["Neuron of lateral ventricle."], "t": []}], "preferred_name": "lateral ventricle neuron", "taxa": []}
{"type": "biolink:Cell", "ic": 86.30756602822301, "identifiers": [{"i": "CL:4300366", "l": "oligodendrocyte precursor cell (Mmus)", "d": ["A oligodendrocyte precursor cell of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Pdgfra (Mmus). Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Subclass:326 OPC NN."], "t": []}], "preferred_name": "oligodendrocyte precursor cell (Mmus)", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C2325047", "l": "Martinotti cell of cerebral cortex", "d": [], "t": []}], "preferred_name": "Martinotti cell of cerebral cortex", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5700419", "l": "Anti-BCMA-CAR-41BB-CD3zeta-expressing T-cells CT053", "d": [], "t": []}], "preferred_name": "Anti-BCMA-CAR-41BB-CD3zeta-expressing T-cells CT053", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:1000492", "l": "mesothelial cell of parietal pleura", "d": ["A mesothelial cell that is part of the parietal pleura."], "t": []}], "preferred_name": "mesothelial cell of parietal pleura", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C3890599", "l": "Circulating Melanoma Cell", "d": [], "t": []}, {"i": "NCIT:C118497", "l": "Circulating Melanoma Cell", "d": ["A melanoma-derived cell found in the peripheral blood."], "t": []}], "preferred_name": "Circulating Melanoma Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 78.29800561113302, "identifiers": [{"i": "UMLS:C1518994", "l": "Peripheral B-Lymphocyte", "d": [], "t": []}, {"i": "NCIT:C38330", "l": "Peripheral B-Lymphocyte", "d": ["A mature B-lymphocyte outside the bone marrow. It may be in the general circulation or in lymphatic tissue."], "t": []}], "preferred_name": "Peripheral B-Lymphocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C4522300", "l": "CD19CAR-CD28-CD3zeta-EGFRt-expressing Tn/mem-enriched T-lymphocytes", "d": [], "t": []}, {"i": "NCIT:C133073", "l": "CD19CAR-CD28-CD3zeta-EGFRt-expressing Tn/mem-enriched T-lymphocytes", "d": ["A preparation of genetically modified lymphocytes comprised of CD62L-positive naïve and memory T-cells (Tn/mem), that are transduced ex vivo with a self-inactivating (SIN) lentiviral vector expressing a hinge-optimized chimeric antigen receptor (CAR) specific for the CD19 antigen and containing CD28 and CD3 zeta signaling domains, and a truncated form of the human epidermal growth factor receptor (EGFRt), with potential immunostimulating and antineoplastic activities. Upon isolation of peripheral blood lymphocytes (PBLs), transduction of the CD62L-positive T-lymphocytes, expansion ex vivo and administration, the CD19R(EQ)-CD28-CD3zeta-EGFRt-expressing Tn/mem-enriched T-cells target CD19-expressing tumor cells, thereby inducing selective toxicity in CD19-expressing tumor cells. CD19 antigen is a B-cell specific cell surface antigen expressed in all B-cell lineage malignancies.  Devoid of both ligand binding domains and tyrosine kinase activity, EGFRt both facilitates in vivo detection of the administered T-cells and can promote elimination of those cells upon a cetuximab-induced antibody dependent cellular cytotoxicity response. Tn/mem T-cells include naïve T-cells, central memory T-cells (Tcm) and stem cell memory T-cells (Tscm). CD19R(EQ) contains two point mutations in the immunoglobulin (Ig) G4 spacer region, thereby preventing recognition of the CAR by Fc receptors (FcRs)."], "t": []}], "preferred_name": "CD19CAR-CD28-CD3zeta-EGFRt-expressing Tn/mem-enriched T-lymphocytes", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4033152", "l": "jugular ganglion TRPV1 neuron", "d": ["A sensory neuron that has the soma located in the jugular ganglion and expresses the marker transient receptor potential vanilloid 1 (TRPV1)."], "t": []}], "preferred_name": "jugular ganglion TRPV1 neuron", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1440051", "l": "Abnormal blood cells.CD19", "d": [], "t": []}], "preferred_name": "Abnormal blood cells.CD19", "taxa": []}
{"type": "biolink:Cell", "ic": 73.15076615569336, "identifiers": [{"i": "CL:0000357", "l": "stratified epithelial stem cell", "d": [], "t": []}], "preferred_name": "stratified epithelial stem cell", "taxa": []}
{"type": "biolink:Cell", "ic": 90.871710685482, "identifiers": [{"i": "CL:2000016", "l": "lung microvascular endothelial cell", "d": ["Any lung endothelial cell that is part of a microvascular endothelium."], "t": []}], "preferred_name": "lung microvascular endothelial cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C6070888", "l": "CD25+CD19+ cells | Blood | Cell markers", "d": [], "t": []}], "preferred_name": "CD25+CD19+ cells | Blood | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:1000346", "l": "enterocyte of epithelium proper of large intestine", "d": ["An enterocyte that is part of the epithelium proper of large intestine."], "t": []}, {"i": "UMLS:C2339015", "l": "Vacuolar absorptive cell of epithelium proper of large intestine", "d": [], "t": []}], "preferred_name": "enterocyte of epithelium proper of large intestine", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5216281", "l": "Mononuclear cells|NCnc|Pt|Plr fld", "d": [], "t": []}], "preferred_name": "Mononuclear cells|NCnc|Pt|Plr fld", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1440345", "l": "CD66c+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:1372923005", "l": "", "d": [], "t": []}], "preferred_name": "CD66c+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:1000418", "l": "myoepithelial cell of lactiferous alveolus", "d": ["A myoepithelial cell that is part of the mammary gland alveolus."], "t": []}, {"i": "UMLS:C1180271", "l": "Myoepithelial cell of lactiferous alveolus", "d": [], "t": []}], "preferred_name": "myoepithelial cell of lactiferous alveolus", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:1001578", "l": "vagina squamous cell", "d": ["Squamous cell of vaginal epithelium."], "t": []}], "preferred_name": "vagina squamous cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1272578", "l": "Skin fibroblast", "d": [], "t": []}, {"i": "SNOMEDCT:386121006", "l": "", "d": [], "t": []}], "preferred_name": "Skin fibroblast", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5157600", "l": "CD5+CD23+ cells | Blood | Cell markers", "d": [], "t": []}], "preferred_name": "CD5+CD23+ cells | Blood | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1511007", "l": "BG02", "d": [], "t": []}, {"i": "NCIT:C20234", "l": "BG02", "d": ["Provider: BresaGen, Inc., Athens, GA. Information from provider and not independently verified by NIH: Cells are positive for cell markers SSEA-3, SSEA-4, TRA 1-60, TRA 1-81, Oct-4, and alkaline phosphatase; Cells are negative for the cell marker SSEA1. This cell line meets the criteria for the use of human embryonic stem cells by federally funded researchers."], "t": []}], "preferred_name": "BG02", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:1000298", "l": "mesothelial cell of dura mater", "d": ["A mesothelial cell that is part of the dura mater."], "t": []}, {"i": "UMLS:C2323029", "l": "Mesothelial cell of dura mater", "d": [], "t": []}], "preferred_name": "mesothelial cell of dura mater", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1955939", "l": "Lymphoid Progenitor Cells", "d": [], "t": []}, {"i": "NCIT:C13012", "l": "Lymphoid Progenitor Cell", "d": ["A hematopoietic stem cell that is committed to differentiate into T-, B- and natural killer (NK) cells."], "t": []}, {"i": "MESH:D054503", "l": "Lymphoid Progenitor Cells", "d": [], "t": []}], "preferred_name": "Lymphoid Progenitor Cells", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5186735", "l": "Leukocytes | Fetus | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Leukocytes | Fetus | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0001055", "l": "CD14-positive, CD16-low monocyte", "d": ["An intermediate monocyte that is CD14-positive and with low amounts of CD16."], "t": []}], "preferred_name": "CD14-positive, CD16-low monocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 59.09204608367191, "identifiers": [{"i": "CL:0000518", "l": "phagocyte (sensu Vertebrata)", "d": ["A phagocyte in vertebrates that is able to phagocytosis."], "t": []}], "preferred_name": "phagocyte (sensu Vertebrata)", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5167386", "l": "Histiocytes | Cerebral spinal fluid | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Histiocytes | Cerebral spinal fluid | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5854353", "l": "Allogeneic Natural Killer Cells SAR445419", "d": [], "t": []}], "preferred_name": "Allogeneic Natural Killer Cells SAR445419", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C4733629", "l": "Autologous Cervical Cancer-specific Engineered Immune Effector Cells", "d": [], "t": []}, {"i": "NCIT:C155657", "l": "Autologous Cervical Cancer-specific Engineered Immune Effector Cells", "d": ["A preparation of autologous immune effector cells genetically modified to target a not yet disclosed cervical cancer-specific tumor-associated antigen (TAA), with potential immunomodulating and antineoplastic activities. After isolation, transduction, expansion in culture, and reintroduction into the patient, the autologous cervical cancer-specific engineered immune effector (CC-EIE) cells bind to and induce selective toxicity in tumor cells expressing the TAA."], "t": []}], "preferred_name": "Autologous Cervical Cancer-specific Engineered Immune Effector Cells", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C3251824", "l": "Cell positive for CD4 antigen", "d": [], "t": []}, {"i": "SNOMEDCT:116745007", "l": "", "d": [], "t": []}], "preferred_name": "Cell positive for CD4 antigen", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1510930", "l": "Anti-MART-1 TCR Retroviral Vector-Transduced Autologous TIL", "d": [], "t": []}, {"i": "NCIT:C38137", "l": "Anti-MART-1 TCR Retroviral Vector-Transduced Autologous TIL", "d": ["Human tumor infiltrating lymphocytes (TIL) isolated from a melanoma patient and were engineered to react with the melanoma antigen MART-1 (Melanoma Antigen Recognized by T cells, also called Melan-A). These TILs are transfected with a retroviral vector encoding anti-MART-1 specific T-cell receptors, grown in culture, and then transferred back to the patient. These genetically modified TIL may recognize and halt the growth of MART-1-expressing melanoma cells."], "t": []}], "preferred_name": "Anti-MART-1 TCR Retroviral Vector-Transduced Autologous TIL", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4737460", "l": "terminal deoxyribonucleotidyl transferase cells per 100 cells", "d": [], "t": []}], "preferred_name": "terminal deoxyribonucleotidyl transferase cells per 100 cells", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5175157", "l": "Nucleated erythrocytes | Blood | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Nucleated erythrocytes | Blood | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0009057", "l": "anorectum goblet cell", "d": ["A goblet cell that is located in the anorectum."], "t": []}], "preferred_name": "anorectum goblet cell", "taxa": []}
{"type": "biolink:Cell", "ic": 77.82747199602274, "identifiers": [{"i": "UMLS:C1711385", "l": "Primitive Malignant Skeletal Muscle Cell", "d": [], "t": []}, {"i": "NCIT:C49202", "l": "Primitive Malignant Skeletal Muscle Cell", "d": [], "t": []}], "preferred_name": "Primitive Malignant Skeletal Muscle Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C4725931", "l": "Autologous Tumor-specific Antigen-loaded Dendritic Cells", "d": [], "t": []}, {"i": "NCIT:C150697", "l": "Autologous Tumor-specific Antigen-loaded Dendritic Cells", "d": ["A cell-based cancer vaccine composed of autologous dendritic cells (DCs) loaded with tumor-specific antigen(s) (TSAs), with potential immunostimulatory and antineoplastic activities. Upon administration of the autologous TSA-loaded DCs, the DCs stimulate a specific cytotoxic T-lymphocyte (CTL)-mediated immune response against the tumor cells expressing the TSA(s), resulting in tumor cell lysis."], "t": []}], "preferred_name": "Autologous Tumor-specific Antigen-loaded Dendritic Cells", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5157924", "l": "Cells | Pleural fluid | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Cells | Pleural fluid | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": 92.76600187037766, "identifiers": [{"i": "CL:0000347", "l": "scleral cell", "d": ["A cell of the sclera of the eye."], "t": []}], "preferred_name": "scleral cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5157346", "l": "CD19 cells | Bone marrow | Cell markers", "d": [], "t": []}], "preferred_name": "CD19 cells | Bone marrow | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0080202", "l": "T-Lymphocyte Subsets", "d": [], "t": []}, {"i": "MESH:D016176", "l": "T-Lymphocyte Subsets", "d": [], "t": []}], "preferred_name": "T-Lymphocyte Subsets", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C3641664", "l": "Autologous Bone Marrow-derived CD34/CXCR4-positive Stem Cells AMR-001", "d": [], "t": []}, {"i": "NCIT:C103865", "l": "Autologous Bone Marrow-derived CD34/CXCR4-positive Stem Cells AMR-001", "d": ["A cell-based product containing autologous bone marrow derived CD34 positive and C-X-C chemokine receptor type 4 (CXCR4) positive stem cells with potential antiapoptotic and proangiogenic activities. Upon intracoronary infusion after a myocardial infarction (MI), autologous bone marrow-derived CD34/CXCR4-positive stem cells may preserve cardiac muscle cells and prevent apoptosis; thus improving myocardial perfusion. CD34/CXCR4-positive stem cells are naturally mobilized upon cell injury through signaling by hypoxia inducing factor (HIF), which is secreted in response to hypoxia. In turn, HIF induces the synthesis of stromal-derived factor 1 (SDF-1) and vascular endothelial growth factor (VEGF) which mobilize CD34/CXCR4 positive stem cells; CXCR4 is the receptor for stromal-derived factor 1 (SDF-1)."], "t": []}], "preferred_name": "Autologous Bone Marrow-derived CD34/CXCR4-positive Stem Cells AMR-001", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5157296", "l": "CD13 blasts | Bone marrow | Cell markers", "d": [], "t": []}], "preferred_name": "CD13 blasts | Bone marrow | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5380987", "l": "Cells.CD8.HLA-B35 CMV specific.CMV antigen stimulated CD107a+b expressing", "d": [], "t": []}], "preferred_name": "Cells.CD8.HLA-B35 CMV specific.CMV antigen stimulated CD107a+b expressing", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0002589", "l": "smooth muscle cell of the brachiocephalic vasculature", "d": ["A smooth muscle cell of the bachiocephalic vasculature."], "t": []}], "preferred_name": "smooth muscle cell of the brachiocephalic vasculature", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4307101", "l": "NFOL NN_2 Il23a newly formed oligodendrocyte (Mmus)", "d": ["A newly formed oligodendrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of 9630013A20Rik (Mmus), Piezo2 (Mmus), Ptprb (Mmus). It is distinguished from other NFOL NN_2 cells by expression of Il23a, Opalin, Ptprb. These cells are located in the Isocortex, brain . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5281 NFOL NN_2."], "t": []}], "preferred_name": "NFOL NN_2 Il23a newly formed oligodendrocyte (Mmus)", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0002442", "l": "CD94-negative, Ly49CI-negative natural killer cell, mouse", "d": ["A NK1.1-positive T cell that is CD94-negative and Ly49Cl-negative."], "t": []}], "preferred_name": "CD94-negative, Ly49CI-negative natural killer cell, mouse", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C4724803", "l": "NY-ESO-1/MAGE-A4/PRAME/Survivin/SSX2-specific Autologous Cytotoxic T Lymphocytes", "d": [], "t": []}, {"i": "NCIT:C118367", "l": "NY-ESO-1/MAGE-A4/PRAME/Survivin/SSX2-specific Autologous Cytotoxic T Lymphocytes", "d": ["A preparation of autologous cytotoxic T-lymphocytes (CTL) that are specifically reactive to five tumor-associated antigens (TAAs), cancer-testis antigen NY-ESO-1, melanoma-associated antigen 4 (MAGE-A4), preferentially expressed antigen in melanoma (PRAME), survivin and synovial sarcoma X breakpoint 2 (SSX2; cancer/testis antigen 5.2; CT5.2), with potential antineoplastic activity. Autologous peripheral blood mononuclear cells (PBMCs) are collected and exposed ex vivo to autologous dendritic cells (DCs) that are pulsed with pepmixes, which contain overlapping peptide libraries (15 mers overlapping by 11 amino acids) spanning the entire sequence of each of the five target antigens, and simultaneously treated with the Th1-polarizing and pro-proliferative cytokines interleukin (IL) 6 (IL-6), IL-7, IL-12 and IL-15. The treated cells are expanded in culture with IL-2 and IL-15. Upon administration of the NY-ESO-1/MAGE-A4/PRAME/survivin/SSX2-specific autologous CTLs, these cells target tumor cells expressing these TAAs, which leads to cell lysis and inhibition of cell proliferation. These five TAAs are upregulated in a variety of tumor cells and play key roles in tumor cell proliferation and survival, but are absent or minimally expressed on normal, healthy human cells."], "t": []}], "preferred_name": "NY-ESO-1/MAGE-A4/PRAME/Survivin/SSX2-specific Autologous Cytotoxic T Lymphocytes", "taxa": []}
{"type": "biolink:Cell", "ic": 90.871710685482, "identifiers": [{"i": "CL:0002292", "l": "type I cell of carotid body", "d": ["A round or oval neuroepithelial cell that contacts other type I cells or capillaries. They occur in clusters that are surrounded by sheath cells (type-II cells) in the carotid body. This cell type is capable of secreting a number of neurotransmitters."], "t": []}], "preferred_name": "type I cell of carotid body", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4072019", "l": "SCN pacemaker neuron", "d": ["A type of neuron located in the suprachiasmatic nucleus (SCN) that possesses intrinsic circadian rhythmicity, characterized by strong and rhythmic expression of core clock genes and the ability to independently generate and sustain circadian oscillations. In mice, the specific subtypes Avp+/Nms+, Vip+/Nms+, and Cck+/C1ql3+ neurons have the most robust circadian gene expression and contribute to synchronizing and maintaining rhythmicity within the SCN network (Wen et al., 2020)."], "t": []}], "preferred_name": "SCN pacemaker neuron", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4047004", "l": "cycling type EC enteroendocrine cell", "d": ["A(n) type EC enteroendocrine cell that is cycling."], "t": []}], "preferred_name": "cycling type EC enteroendocrine cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0206152", "l": "Cell Transplants", "d": [], "t": []}], "preferred_name": "Cell Transplants", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5157921", "l": "Cells | Cervical mucus | Fertility testing", "d": [], "t": []}], "preferred_name": "Cells | Cervical mucus | Fertility testing", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0000929", "l": "CD4-negative, CD8-negative type I NK T cell secreting interferon-gamma", "d": ["A mature NK T cell that secretes interferon-gamma and enhances Th1 immune responses."], "t": []}], "preferred_name": "CD4-negative, CD8-negative type I NK T cell secreting interferon-gamma", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5157229", "l": "CD1 blasts | Bone marrow | Cell markers", "d": [], "t": []}], "preferred_name": "CD1 blasts | Bone marrow | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1276861", "l": "Entire endometrial glandular cell", "d": [], "t": []}, {"i": "SNOMEDCT:254032002", "l": "", "d": [], "t": []}], "preferred_name": "Entire endometrial glandular cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C4329326", "l": "Anti-Glypican 3-scFvGC33-CAR-expressing T Lymphocytes", "d": [], "t": []}, {"i": "NCIT:C132989", "l": "Anti-Glypican 3-scFvGC33-CAR-expressing T Lymphocytes", "d": ["A preparation of autologous T-lymphocytes that have been genetically modified to express a chimeric antigen receptor (CAR) containing a single chain variable fragment (scFv) derived from the anti-glypican-3 (GPC3) monoclonal antibody GC33 (scFvGC33), with potential immunostimulating and antineoplastic activities. Upon administration, anti-GPC3-scFvGC33-CAR autologous T-lymphocytes specifically target and bind to GPC3-expressing tumor cells, resulting in tumor cell lysis. GPC3, a heparan sulfate proteoglycan and a member of the glypican family, is overexpressed on certain tumor cell types while minimally expressed in normal, healthy cells.. GPC3 plays an important role in cellular proliferation and differentiation."], "t": []}], "preferred_name": "Anti-Glypican 3-scFvGC33-CAR-expressing T Lymphocytes", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C4726059", "l": "Autologous CD19-CD8-CD28-CD3zeta-CAR-mbIL15-HER1t T Cells", "d": [], "t": []}, {"i": "NCIT:C150906", "l": "Autologous CD19-CD8-CD28-CD3zeta-CAR-mbIL15-HER1t T Cells", "d": ["A preparation of autologous, genetically modified T-lymphocytes, that have been electroporated ex vivo with sleeping beauty (SB)-derived DNA plasmids, expressing a second-generation chimeric antigen receptor (CAR) composed of a mouse single-chain variable fragment (scFv) specific for the tumor-associated antigen (TAA) cluster of differentiation 19 (CD19) that is linked to the co-stimulatory molecules T-cell surface glycoproteins CD8 and CD28 and the zeta chain of the T-cell receptor (TCR)/CD3 complex (CD3-zeta) and co-expressed with a chimeric membrane-bound fusion protein comprised of interleukin-15 (IL-15) fused to IL-15 receptor (mbIL15) and a safety/kill switch composed of a truncated form of the human epidermal growth factor receptor (ErbB1t; EGFR) (HER1t), with potential immunostimulating and antineoplastic activities. Upon reintroduction of the autologous CD19-CD8-CD28-CD3zeta-CAR-mbIL15-HER1t T cells into the patient, the T-cells target and bind to CD19-expressing tumor cells, thereby inducing selective toxicity in CD19-expressing tumor cells. CD19 is a B-cell specific cell surface antigen expressed in all B-cell lineage malignancies.  HER1t can promote selective elimination of the CAR-T cells through cetuximab-induced antibody-dependent cellular cytotoxicity (ADCC) and complement-dependent cytotoxicity (CDC). IL-15 is a pro-survival cytokine that is required for the maintenance of long-lived CD8+ memory T-cells and use of mbIL15 preserves T stem-cell memory (TSCM) through sustained IL-15 signaling, improves T-cell persistence and potentiates the immune response against tumor cells. The SB system permits electroporation of the CAR, the IL-15 fusion variant and safety switch transgenes into T-cells without the need for viral vectors and accelerates the manufacturing process."], "t": []}], "preferred_name": "Autologous CD19-CD8-CD28-CD3zeta-CAR-mbIL15-HER1t T Cells", "taxa": []}
{"type": "biolink:Cell", "ic": 59.950602523335895, "identifiers": [{"i": "CL:0008059", "l": "GABA-Gly neuron", "d": ["A neuron that releases both gamma-aminobutyric acid and glycine as vesicular neurotransmitters.  Examples include types of amacrine cell and types of cerebellar inhibitory neurons."], "t": []}], "preferred_name": "GABA-Gly neuron", "taxa": []}
{"type": "biolink:Cell", "ic": 88.20185721311867, "identifiers": [{"i": "CL:0000052", "l": "totipotent stem cell", "d": ["A stem cell from which all cells of the body can form."], "t": []}, {"i": "UMLS:C0872372", "l": "Totipotent Stem Cells", "d": [], "t": []}, {"i": "NCIT:C12978", "l": "Totipotent Stem Cell", "d": ["Totipotent stem cells, such as the product of fertilization of an ovum and its progeny, are stem cells that have total potency to form an entire mature organism, e.g., a human being, although only if placed in a woman's uterus."], "t": []}, {"i": "MESH:D039901", "l": "Totipotent Stem Cells", "d": [], "t": []}], "preferred_name": "totipotent stem cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C6056171", "l": "Allogeneic anti-CD20 CAR T cells", "d": [], "t": []}], "preferred_name": "Allogeneic anti-CD20 CAR T cells", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C4524566", "l": "Hematopoietic Progenitor Cells from Cord Blood", "d": [], "t": []}, {"i": "NCIT:C133329", "l": "Hematopoietic Progenitor Cells from Cord Blood", "d": ["Blood collected from the umbilical cord as a source of hematopoietic progenitor cells."], "t": []}], "preferred_name": "Hematopoietic Progenitor Cells from Cord Blood", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5222946", "l": "CD3- CD16+ cells/100 cells in bone marrow", "d": [], "t": []}], "preferred_name": "CD3- CD16+ cells/100 cells in bone marrow", "taxa": []}
{"type": "biolink:Cell", "ic": 84.83823963392128, "identifiers": [{"i": "UMLS:C1514112", "l": "Neoplastic T-Prolymphocyte", "d": [], "t": []}, {"i": "NCIT:C37184", "l": "Neoplastic T-Prolymphocyte", "d": [], "t": []}], "preferred_name": "Neoplastic T-Prolymphocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5706560", "l": "Allogeneic DNT Cells RC1012", "d": [], "t": []}, {"i": "NCIT:C189910", "l": "Allogeneic DNT Cells RC1012", "d": ["A population of off-the-shelf (OTS) healthy, donor-derived CD4 and CD8 double-negative T-lymphocytes (allo-DNTs), with potential immunomodulating and anti-leukemic activities. The DNTs are expanded ex vivo in order to enhance their tumor destroying potential. Upon administration of the allo-DNTs RC1012, the receptor type II integral membrane protein (KLRK1; NKG2D) and DNAX accessory molecule 1 (cluster of differentiation 226; CD226; DNAM-1) expressed on the DNTs recognize and bind to their cognate ligands expressed on leukemia cells. Upon binding, the DNTs release interferon-gamma (IFN-g), thereby destroying the tumor cells. NKG2D, a member of the CD94/NKG2 family of C-type lectin-like receptors, and DNAM-1, a member of the immunoglobulin superfamily containing 2 Ig-like domains of the V-set, play a key role in natural killer cell (NK)-mediated tumor cell killing. Certain tumor cells express higher levels of NKG2D and DNAM-1 ligands on their surfaces, thereby increasing their susceptibility to DNT-mediated cell lysis."], "t": []}], "preferred_name": "Allogeneic DNT Cells RC1012", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C4763592", "l": "Autologous CD34-positive BCL11A-disrupted Hematopoietic Progenitor Cells BIVV003", "d": [], "t": []}, {"i": "NCIT:C157393", "l": "Autologous CD34-positive BCL11A-disrupted Hematopoietic Progenitor Cells BIVV003", "d": ["A population of autologous cluster of differentiation 34 (CD34)-positive hematopoietic progenitor cells (HPCs) that are transfected ex vivo with zinc finger nuclease (ZFN) messenger ribonucleic acid (mRNA) targeting the B-cell lymphoma/leukemia 11A (BCL11A) locus, with potential usage for transplantation in patients with sickle cell disease (SCD). CD34-positive HPCs are isolated from human blood upon apheresis and are genetically modified in vitro using ZFN technology to specifically cleave and disrupt the erythroid enhancer of the BCL11A gene. This suppresses the production of sickle hemoglobin. Upon infusion into the patient following conditioning chemotherapy, the autologous CD34-positive BCL11A-disrupted HPCs BIVV003 can populate the bone marrow and differentiate into a variety of blood cell types including lymphoid cells, myeloid cells and erythroblasts. As BCL11A is a suppressor of fetal hemoglobin (HbF) expression, disruption of the BCL11A enhancer decreases the expression of BCL11A and stimulates the expression of HbF in erythrocytes that differentiate from BIVV003. HbF may compensate for reduced or absent expression of adult hemoglobin in patients with SCD."], "t": []}], "preferred_name": "Autologous CD34-positive BCL11A-disrupted Hematopoietic Progenitor Cells BIVV003", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0682540", "l": "spindle cell", "d": [], "t": []}], "preferred_name": "spindle cell", "taxa": []}
{"type": "biolink:Cell", "ic": 89.40238429118027, "identifiers": [{"i": "CL:0000525", "l": "syncytiotrophoblast cell", "d": ["A cell from the outer syncytial layer of the trophoblast of an early mammalian embryo, directly associated with the maternal blood supply. It secretes hCG in order to maintain progesterone secretion and sustain a pregnancy."], "t": []}, {"i": "UMLS:C1515108", "l": "Syncytiotrophoblast cell", "d": [], "t": []}, {"i": "NCIT:C38574", "l": "Syncytiotrophoblastic Cell", "d": ["A large, multinucleated cell having hyperchromatic nuclei and abundant eosinophilic, sometimes vacuolated cytoplasm, in the outer syncytial layer of the trophoblast."], "t": []}], "preferred_name": "syncytiotrophoblast cell", "taxa": []}
{"type": "biolink:Cell", "ic": 85.53200374075534, "identifiers": [{"i": "CL:0000694", "l": "R3 photoreceptor cell", "d": [], "t": []}], "preferred_name": "R3 photoreceptor cell", "taxa": []}
{"type": "biolink:Cell", "ic": 92.76600187037766, "identifiers": [{"i": "CL:1001066", "l": "kidney arteriole smooth muscle cell", "d": [], "t": []}], "preferred_name": "kidney arteriole smooth muscle cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5908657", "l": "CD33-specific CAR Lentiviral Vector-transduced Allogeneic T-lymphocytes", "d": [], "t": []}, {"i": "NCIT:C202648", "l": "CD33-specific CAR Lentiviral Vector-transduced Allogeneic T-lymphocytes", "d": ["A preparation of allogeneic T-lymphocytes transduced with a lentiviral vector expressing a chimeric antigen receptor (CAR) specific for the CD33 antigen, with potential immunomodulating and antineoplastic activities. Upon administration, CD33-specific CAR lentiviral vector-transduced allogeneic T-lymphocytes target and induce selective toxicity in CD33-expressing tumor cells. CD33 is expressed on normal non-pluripotent hematopoietic stem cells and on myeloid leukemia cells."], "t": []}], "preferred_name": "CD33-specific CAR Lentiviral Vector-transduced Allogeneic T-lymphocytes", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4070017", "l": "lateral pyloric motor neuron", "d": ["A motor neuron that controls pyloric filter movements; innervates the lateral pyloric muscle."], "t": []}], "preferred_name": "lateral pyloric motor neuron", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5163539", "l": "Epithelial cells | Nose | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Epithelial cells | Nose | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4510921", "l": "Blast cell positive for CD19 antigen", "d": [], "t": []}, {"i": "SNOMEDCT:725177004", "l": "", "d": [], "t": []}], "preferred_name": "Blast cell positive for CD19 antigen", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1181541", "l": "Type I cell of paraganglion", "d": [], "t": []}], "preferred_name": "Type I cell of paraganglion", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "CL:0004246", "l": "monostratified cell", "d": ["A central nervous system neuron that stratifies at one and only one location."], "t": []}], "preferred_name": "monostratified cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0080261", "l": "Tumor-Derived Activated Cells", "d": [], "t": []}], "preferred_name": "Tumor-Derived Activated Cells", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C3652431", "l": "limbal stem cells, autologous", "d": [], "t": []}], "preferred_name": "limbal stem cells, autologous", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "CL:4030048", "l": "striosomal D1 medium spiny neuron", "d": ["A DRD1-expressing medium spiny neuron that is part of a striosome of dorsal striatum."], "t": []}], "preferred_name": "striosomal D1 medium spiny neuron", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5687320", "l": "Population of all neutrophilic metamyelocytes in portion of fluid", "d": [], "t": []}, {"i": "SNOMEDCT:1208766005", "l": "", "d": [], "t": []}], "preferred_name": "Population of all neutrophilic metamyelocytes in portion of fluid", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0009018", "l": "lymphocyte of large intestine lamina propria", "d": ["A lymphocyte that resides in the lamina propria of the large intestine."], "t": []}], "preferred_name": "lymphocyte of large intestine lamina propria", "taxa": []}
{"type": "biolink:Cell", "ic": 77.82747199602274, "identifiers": [{"i": "UMLS:C1513966", "l": "Neoplastic Fibroblast-Like Cell", "d": [], "t": []}, {"i": "NCIT:C36959", "l": "Neoplastic Fibroblast-Like Cell", "d": [], "t": []}], "preferred_name": "Neoplastic Fibroblast-Like Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4030000", "l": "choroidal melanocyte", "d": ["A melanocyte located in the vascular uvea and involved in photoprotection, regulation of oxidative damage and immune responses."], "t": []}], "preferred_name": "choroidal melanocyte", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1440275", "l": "CD26+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:1372867008", "l": "", "d": [], "t": []}], "preferred_name": "CD26+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": 90.871710685482, "identifiers": [{"i": "CL:1000339", "l": "enterocyte of epithelium proper of small intestine", "d": ["An enterocyte that is part of the epithelium proper of small intestine."], "t": []}, {"i": "UMLS:C2329779", "l": "Enterocyte of epithelium proper of small intestine", "d": [], "t": []}], "preferred_name": "enterocyte of epithelium proper of small intestine", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4307095", "l": "COP NN_1 Bmp4 committed oligodendrocyte precursor (Mmus)", "d": ["A committed oligodendrocyte precursor of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of 9630013A20Rik (Mmus), Bmp4 (Mmus), Mob3b (Mmus). It is distinguished from other COP NN_1 cells by expression of Bmp4, Mob3b. These cells are located in the brain . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5275 COP NN_1."], "t": []}], "preferred_name": "COP NN_1 Bmp4 committed oligodendrocyte precursor (Mmus)", "taxa": []}
{"type": "biolink:Cell", "ic": 70.22551955196433, "identifiers": [{"i": "CL:0010009", "l": "camera-type eye photoreceptor cell", "d": ["Any photoreceptor cell that is part of some camera-type eye."], "t": []}], "preferred_name": "camera-type eye photoreceptor cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5787322", "l": "Differentiated Cell Specimen", "d": [], "t": []}, {"i": "NCIT:C192999", "l": "Differentiated Cell Specimen", "d": ["A biospecimen consisting of cells that have acquired specialized structural or functional features."], "t": []}], "preferred_name": "Differentiated Cell Specimen", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1267914", "l": "Lymphocyte positive for CD37 antigen", "d": [], "t": []}, {"i": "SNOMEDCT:117583000", "l": "", "d": [], "t": []}], "preferred_name": "Lymphocyte positive for CD37 antigen", "taxa": []}
{"type": "biolink:Cell", "ic": 89.40238429118027, "identifiers": [{"i": "CL:4033078", "l": "cycling mononuclear phagocyte", "d": ["A(n) mononuclear phagocyte that is cycling."], "t": []}], "preferred_name": "cycling mononuclear phagocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5669563", "l": "Firolimogene Autotemcel", "d": [], "t": []}, {"i": "NCIT:C184824", "l": "Firolimogene Autotemcel", "d": [], "t": []}], "preferred_name": "Firolimogene Autotemcel", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "CL:0002322", "l": "embryonic stem cell", "d": ["A stem cell of embryonic origin."], "t": []}, {"i": "UMLS:C0596508", "l": "Embryonic Stem Cells", "d": [], "t": []}, {"i": "NCIT:C12935", "l": "Embryonic Stem Cell", "d": ["Embryonic stem (ES) cells are cells derived from the inner cell mass of the early embryo that can be propagated indefinitely in the primitive undifferentiated state while remaining pluripotent."], "t": []}, {"i": "MESH:D053595", "l": "Embryonic Stem Cells", "d": [], "t": []}, {"i": "SNOMEDCT:419965008", "l": "", "d": [], "t": []}], "preferred_name": "embryonic stem cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C0427528", "l": "Atypical mononuclear cell", "d": [], "t": []}, {"i": "NCIT:C12979", "l": "Atypical Mononuclear Cell", "d": [], "t": []}, {"i": "SNOMEDCT:250287000", "l": "", "d": [], "t": []}], "preferred_name": "Atypical mononuclear cell", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "UMLS:C4055074", "l": "Effector Memory Immune Cell", "d": [], "t": []}, {"i": "NCIT:C122731", "l": "Effector Memory Immune Cell", "d": ["A population of long-lived antigen-specific immune cells, usually T-lymphocytes expressing CD8 and effector cytokines, that are maintained by the immune system. Upon subsequent exposure to their target antigen, these cells rapidly become effector cells."], "t": []}], "preferred_name": "Effector Memory Immune Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 69.23096947192928, "identifiers": [{"i": "CL:0002584", "l": "renal cortical epithelial cell", "d": ["An epithelial cell of the kidney cortex."], "t": []}], "preferred_name": "renal cortical epithelial cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1440305", "l": "CD4+CD8+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:1373113009", "l": "", "d": [], "t": []}], "preferred_name": "CD4+CD8+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5170931", "l": "Leukocytes | Gastric fluid | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Leukocytes | Gastric fluid | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0230520", "l": "Mitotic cell in metaphase", "d": [], "t": []}, {"i": "SNOMEDCT:38980003", "l": "", "d": [], "t": []}], "preferred_name": "Mitotic cell in metaphase", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0000977", "l": "IgG short lived plasma cell", "d": ["A short lived plasma cell that secretes IgG."], "t": []}], "preferred_name": "IgG short lived plasma cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0002661", "l": "luminal cell of lactiferous terminal ductal lobular unit", "d": ["A luminal cell of terminal ducts, i.e.e the terminal branch of a lactiferous duct which alveolar cells drain into."], "t": []}, {"i": "UMLS:C2340197", "l": "Luminal cell of lactiferous terminal ductal lobular unit", "d": [], "t": []}], "preferred_name": "luminal cell of lactiferous terminal ductal lobular unit", "taxa": []}
{"type": "biolink:Cell", "ic": 79.07356789860069, "identifiers": [{"i": "CL:0000845", "l": "marginal zone B cell of spleen", "d": ["A mature B cell that is located in the marginal zone of the spleen with the phenotype CD23-negative and CD21-positive and expressing a B cell receptor usually reactive to bacterial cell wall components or senescent self components such as oxidized-LDL. This cell type is also described as being CD19-positive, B220-positive, IgM-high, AA4-negative, CD35-high."], "t": []}], "preferred_name": "marginal zone B cell of spleen", "taxa": []}
{"type": "biolink:Cell", "ic": 62.84991018246379, "identifiers": [{"i": "CL:0000207", "l": "olfactory receptor cell", "d": ["Any neuron that is capable of some detection of chemical stimulus involved in sensory perception of smell."], "t": []}], "preferred_name": "olfactory receptor cell", "taxa": []}
{"type": "biolink:Cell", "ic": 73.15076615569336, "identifiers": [{"i": "CL:0008008", "l": "striated visceral muscle cell", "d": ["A visceral muscle cell that is striated.  Examples include the visceral muscle cells of arhtropods."], "t": []}], "preferred_name": "striated visceral muscle cell", "taxa": []}
{"type": "biolink:Cell", "ic": 86.30756602822301, "identifiers": [{"i": "UMLS:C1513950", "l": "Neoplastic Elongated Glial Cell", "d": [], "t": []}, {"i": "NCIT:C37144", "l": "Neoplastic Elongated Glial Cell", "d": [], "t": []}], "preferred_name": "Neoplastic Elongated Glial Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5849098", "l": "Intratumoral Tumor Infiltrating Lymphocyte", "d": [], "t": []}, {"i": "NCIT:C200222", "l": "Intratumoral Tumor Infiltrating Lymphocyte", "d": ["A tumor infiltrating lymphocyte found within a nest of tumor cells, where there is no intervening stroma. These lymphocytes have direct cell-to-cell contact with tumor cells."], "t": []}], "preferred_name": "Intratumoral Tumor Infiltrating Lymphocyte", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5170901", "l": "Leukemia markers | Pleural fluid | Cell markers", "d": [], "t": []}], "preferred_name": "Leukemia markers | Pleural fluid | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C2964562", "l": "Viable CD34 cells", "d": [], "t": []}], "preferred_name": "Viable CD34 cells", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0314590", "l": "Colony-forming unit, granulocyte-monocyte", "d": [], "t": []}], "preferred_name": "Colony-forming unit, granulocyte-monocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 88.20185721311867, "identifiers": [{"i": "CL:0000035", "l": "single fate stem cell", "d": ["A stem cell that self-renews as well as give rise to a single mature cell type."], "t": []}, {"i": "UMLS:C1182623", "l": "Unipotent stem cell", "d": [], "t": []}], "preferred_name": "single fate stem cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5177453", "l": "Plasma cells | Blood | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Plasma cells | Blood | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4072045", "l": "L6b glutamatergic cortical neuron (Homo sapiens)", "d": ["A glutamatergic neuron with a soma found in cortical layer 6b. They are transcriptomically related to corticothalamic-projecting neurons but have differential projections to the thalamus or anterior cingulate. The standard transcriptomic reference data for this cell type can be found on the CellxGene census under the collection: 'Transcriptomic cytoarchitecture reveals principles of human neocortex organization', dataset: 'Supercluster: Deep layer (non-IT) excitatory neuron', Author Categories: 'CrossArea_subclass', cluster L6b."], "t": []}], "preferred_name": "L6b glutamatergic cortical neuron (Homo sapiens)", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0009052", "l": "smooth muscle cell of anorectum", "d": ["A smooth muscle cell that is located in the anorectum."], "t": []}], "preferred_name": "smooth muscle cell of anorectum", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1267985", "l": "Lymphocyte positive for CD98 antigen", "d": [], "t": []}, {"i": "SNOMEDCT:117425007", "l": "", "d": [], "t": []}], "preferred_name": "Lymphocyte positive for CD98 antigen", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "CL:0000238", "l": "non keratinizing barrier epithelial cell", "d": [], "t": []}], "preferred_name": "non keratinizing barrier epithelial cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5216233", "l": "Leukocytes|NCnc|Pt|Bronchial", "d": [], "t": []}], "preferred_name": "Leukocytes|NCnc|Pt|Bronchial", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "CL:0002410", "l": "pancreatic stellate cell", "d": ["A cell that is found in the periacinar space of the exocrine pancreas and in perivascular and periductal regions of the pancreas, and has long cytoplasmic processes that encircle the base of the acinus. Expresses several intermediate filament proteins including vimentin and nestin. Shares many of the characteristics of hepatatic stellate cells, but not stellate cells of the central nervous system. Upon activation, this cell type undergoes morphological and gene expression changes that make the cell suggestive of being a type of myofibroblast."], "t": []}, {"i": "UMLS:C2936598", "l": "Pancreatic Stellate Cells", "d": [], "t": []}, {"i": "NCIT:C107531", "l": "Pancreatic Stellate Cell", "d": ["A star-shaped, myofibroblast-like cell in the pancreas associated with tissue maintenance. When pancreatic stellate cells are activated in response to an injury, they proliferate and synthesize large amounts of extracellular matrix. Pancreatic cancer cells can increase the activation of pancreatic stellate cells, which leads to fibrosis."], "t": []}, {"i": "MESH:D058954", "l": "Pancreatic Stellate Cells", "d": [], "t": []}], "preferred_name": "pancreatic stellate cell", "taxa": []}
{"type": "biolink:Cell", "ic": 62.87330157069668, "identifiers": [{"i": "UMLS:C1882057", "l": "Neoplastic Neuroendocrine Small Cell", "d": [], "t": []}, {"i": "NCIT:C60534", "l": "Neoplastic Neuroendocrine Small Cell", "d": [], "t": []}], "preferred_name": "Neoplastic Neuroendocrine Small Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 75.70995031940328, "identifiers": [{"i": "CL:0000549", "l": "basophilic erythroblast", "d": ["A nucleated immature erythrocyte, having cytoplasm generally similar to that of the earlier proerythroblast but sometimes even more basophilic, and usually regular in outline. The nucleus is still relatively large, but the chromatin strands are thicker and more deeply staining, giving a coarser appearance; the nucleoli have disappeared. This cell is CD71-positive and lacks hematopoeitic lineage markers."], "t": []}, {"i": "UMLS:C0229628", "l": "Basophilic normoblast", "d": [], "t": []}, {"i": "NCIT:C13130", "l": "Basophilic Erythroblast", "d": ["A nucleated red blood cell that stains readily with basic dye."], "t": []}, {"i": "SNOMEDCT:464005", "l": "", "d": [], "t": []}], "preferred_name": "basophilic erythroblast", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0333833", "l": "Ragocyte", "d": [], "t": []}, {"i": "SNOMEDCT:45417004", "l": "", "d": [], "t": []}], "preferred_name": "Ragocyte", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4510906", "l": "Blast cell positive for CD15 antigen", "d": [], "t": []}, {"i": "SNOMEDCT:724251005", "l": "", "d": [], "t": []}], "preferred_name": "Blast cell positive for CD15 antigen", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5157261", "l": "CD117 blasts | Bone marrow | Cell markers", "d": [], "t": []}], "preferred_name": "CD117 blasts | Bone marrow | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5833005", "l": "Erythrocytes.Plasmodium falciparum infected", "d": [], "t": []}], "preferred_name": "Erythrocytes.Plasmodium falciparum infected", "taxa": []}
{"type": "biolink:Cell", "ic": 92.76600187037766, "identifiers": [{"i": "CL:4047038", "l": "dogiel type I neuron", "d": ["A multipolar neuron in the myenteric plexus of the gastrointestinal tract, characterized by a small to medium-sized cell body and multiple short dendrites.  This neuron exhibits fast excitatory postsynaptic potentials and can be classified into stubby, spiny and hairy subtypes based on dendritic morphology. (Brehmer, 2021)"], "t": []}], "preferred_name": "dogiel type I neuron", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4033171", "l": "pelvic ganglion nNOS/VIP neuron", "d": ["A parasympathetic neuron that has the soma located in the pelvic ganglion and expresses the marker neuronal nitric oxide synthase (nNOS) 1 and vasoactive intestinal peptide (VIP)."], "t": []}], "preferred_name": "pelvic ganglion nNOS/VIP neuron", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0002547", "l": "fibroblast of the aortic adventitia", "d": ["A fibroblast of the aortic adventitia."], "t": []}], "preferred_name": "fibroblast of the aortic adventitia", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C2698236", "l": "Mobilized Peripheral Blood Stem Cell", "d": [], "t": []}, {"i": "NCIT:C75576", "l": "Mobilized Peripheral Blood Stem Cell", "d": ["Blood stem cells found in the circulation after being stimulated to leave the bone marrow, usually by treatment with a cytokine or other drug."], "t": []}], "preferred_name": "Mobilized Peripheral Blood Stem Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4028006", "l": "alveolar adventitial fibroblast", "d": ["A pulmonary interstitial fibroblast that is part of the alveolus and localizes to vascular adventitia."], "t": []}], "preferred_name": "alveolar adventitial fibroblast", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "UMLS:C5908198", "l": "CD8 Positive Memory T-Lymphocyte", "d": [], "t": []}, {"i": "NCIT:C201812", "l": "CD8 Positive Memory T-Lymphocyte", "d": ["T lymphocytes that are derived from naïve CD8 expressing T cells that have been primed through antigen exposure, followed by a cycle of proliferation (expansion) and apoptosis (contraction), that yields a long-lasting population of highly antigen-specific memory cells. These cells can be identified by the presence of CD8 and the absence of CD45RA molecules on their surface."], "t": []}], "preferred_name": "CD8 Positive Memory T-Lymphocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 77.60424150429895, "identifiers": [{"i": "CL:4023013", "l": "corticothalamic-projecting glutamatergic cortical neuron", "d": ["A glutamatergic neuron located in the cerebral cortex that projects to the thalamus."], "t": []}], "preferred_name": "corticothalamic-projecting glutamatergic cortical neuron", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0008048", "l": "upper motor neuron", "d": ["A glutamatergic motor neuron with a soma in the brainstem or cerebral cortex.  They do not synapse directly to muscles but rather to lower motor neurons, which do.  They are the main controllers of voluntary movement."], "t": []}], "preferred_name": "upper motor neuron", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5833287", "l": "CD33 cells | Donor | Blood | Cell markers", "d": [], "t": []}], "preferred_name": "CD33 cells | Donor | Blood | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5960775", "l": "Anti-MUC16 CAR T-cells 27T51", "d": [], "t": []}], "preferred_name": "Anti-MUC16 CAR T-cells 27T51", "taxa": []}
{"type": "biolink:Cell", "ic": 84.21065366064373, "identifiers": [{"i": "CL:0000454", "l": "epinephrine secreting cell", "d": ["A cell capable of producing epinephrine. Epiniphrine is synthesized from norepiniphrine by the actions of the phenylethanolamine N-methyltransferase enzyme, which is expressed in the adrenal glands, androgenic neurons, and in other cell types."], "t": []}], "preferred_name": "epinephrine secreting cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0229648", "l": "Nonsegmented basophil", "d": [], "t": []}, {"i": "SNOMEDCT:3383001", "l": "", "d": [], "t": []}], "preferred_name": "Nonsegmented basophil", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0002108", "l": "CD38-negative IgG memory B cell", "d": ["A CD38-negative IgG memory B cell is a IgG-positive class switched memory B cell that has class switched and expresses IgG on the cell surface with the phenotype CD38-negative, IgD-negative, and IgG-positive."], "t": []}], "preferred_name": "CD38-negative IgG memory B cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4033104", "l": "superior cervical ganglion TH/NPY neuron", "d": ["A sympathetic neuron that has the soma located in the superior cervical ganglion and expresses the marker tyrosine hydroxylase (TH) and neuropeptide Y (NPY)."], "t": []}], "preferred_name": "superior cervical ganglion TH/NPY neuron", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1522151", "l": "Mouse Thymocyte", "d": [], "t": []}, {"i": "NCIT:C22583", "l": "Mouse Thymocyte", "d": [], "t": []}], "preferred_name": "Mouse Thymocyte", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5173496", "l": "Mononuclear cells | Dialysis fluid peritoneal | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Mononuclear cells | Dialysis fluid peritoneal | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": 84.21065366064373, "identifiers": [{"i": "CL:1001593", "l": "parathyroid glandular cell", "d": ["Glandular (secretory) cell of parathyroid epithelium."], "t": []}], "preferred_name": "parathyroid glandular cell", "taxa": []}
{"type": "biolink:Cell", "ic": 89.40238429118027, "identifiers": [{"i": "CL:0000722", "l": "cystoblast", "d": [], "t": []}], "preferred_name": "cystoblast", "taxa": []}
{"type": "biolink:Cell", "ic": 86.30756602822301, "identifiers": [{"i": "UMLS:C1516943", "l": "Epithelial Receptor Cell", "d": [], "t": []}, {"i": "NCIT:C13145", "l": "Epithelial Receptor Cell", "d": ["A cell on the surface of the body or lining a body cavity that responds to physical and chemical stimuli by sending information to the central nervous system."], "t": []}], "preferred_name": "Epithelial Receptor Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C4723769", "l": "Therapeutic Invariant Natural Killer T-cells", "d": [], "t": []}, {"i": "NCIT:C148557", "l": "Therapeutic Invariant Natural Killer T-cells", "d": ["A preparation of natural killer T-cells (NKTs) expressing an invariant (alpha, beta) T-cell receptor (iNKTs), with potential immunomodulating and antineoplastic activities. Upon infusion of the therapeutic iNKTs, these cells recognize CD1d-restricted lipid ligands, which are expressed on certain tumor cells, and secrete large amounts of various cytokines. This may activate the immune system against tumor cells. Additionally, iNKTs directly target and lyse tumor cells."], "t": []}], "preferred_name": "Therapeutic Invariant Natural Killer T-cells", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5216227", "l": "Leukocytes other|NCnc|Pt|Periton fld", "d": [], "t": []}], "preferred_name": "Leukocytes other|NCnc|Pt|Periton fld", "taxa": []}
{"type": "biolink:Cell", "ic": 58.82060815034062, "identifiers": [{"i": "CL:0000667", "l": "collagen secreting cell", "d": ["An extracellular matrix secreting cell that secretes collagen."], "t": []}], "preferred_name": "collagen secreting cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5419240", "l": "Cenplacel-L", "d": [], "t": []}, {"i": "NCIT:C171653", "l": "Cenplacel-L", "d": [], "t": []}], "preferred_name": "Cenplacel-L", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0002596", "l": "smooth muscle cell of the carotid artery", "d": ["Smooth muscle cell of the carotid artery."], "t": []}], "preferred_name": "smooth muscle cell of the carotid artery", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:1000355", "l": "microfold cell of epithelium proper of small intestine", "d": ["A M cell that is part of the epithelium proper of small intestine."], "t": []}, {"i": "UMLS:C2338276", "l": "Microfold cell of epithelium proper of small intestine", "d": [], "t": []}], "preferred_name": "microfold cell of epithelium proper of small intestine", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5157311", "l": "CD14 Monocytes | Blood | Cell markers", "d": [], "t": []}], "preferred_name": "CD14 Monocytes | Blood | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": 52.622074089889104, "identifiers": [{"i": "CL:0000334", "l": "vegetative cell (sensu Fungi)", "d": [], "t": []}], "preferred_name": "vegetative cell (sensu Fungi)", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C6064635", "l": "CD28+HLA-DR+", "d": [], "t": []}, {"i": "SNOMEDCT:1384201009", "l": "", "d": [], "t": []}], "preferred_name": "CD28+HLA-DR+", "taxa": []}
{"type": "biolink:Cell", "ic": 59.84620015040151, "identifiers": [{"i": "CL:0000232", "l": "erythrocyte", "d": ["A red blood cell. In mammals, mature erythrocytes are biconcave disks containing hemoglobin whose function is to transport oxygen."], "t": []}, {"i": "UMLS:C0014792", "l": "Erythrocytes", "d": [], "t": []}, {"i": "NCIT:C12521", "l": "Erythrocyte", "d": ["A blood cell specialized for oxygen transport, having a high concentration of hemoglobin in the cytoplasm. They are biconcave, anucleate discs, with a 6-8um diameter in humans."], "t": []}, {"i": "MESH:D004912", "l": "Erythrocytes", "d": [], "t": []}, {"i": "SNOMEDCT:41898006", "l": "", "d": [], "t": []}], "preferred_name": "erythrocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 92.76600187037766, "identifiers": [{"i": "CL:4023189", "l": "parasol ganglion cell of retina", "d": ["A retinal ganglion cell located in the ganglion cell layer of the retina. This cell projects to magnocellular cells in the lateral geniculate nucleus (LGN). They have large cell bodies and extensive, branching dendritic networks that contribute to their large receptive fields."], "t": []}, {"i": "UMLS:C2323492", "l": "Parasol ganglion cell of retina", "d": [], "t": []}], "preferred_name": "parasol ganglion cell of retina", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4033100", "l": "atrial intrinsic cardiac ganglion TH neuron", "d": ["A sympathetic neuron that has the soma located in the atrial intrinsic cardiac ganglion and expresses the marker tyrosine hydroxylase (TH)."], "t": []}], "preferred_name": "atrial intrinsic cardiac ganglion TH neuron", "taxa": []}
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{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1519376", "l": "Small Lymphocyte-Like Neoplastic Germ Cell", "d": [], "t": []}, {"i": "NCIT:C37131", "l": "Small Lymphocyte-Like Neoplastic Germ Cell", "d": [], "t": []}], "preferred_name": "Small Lymphocyte-Like Neoplastic Germ Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5784715", "l": "Autologous Tumor Infiltrating Lymphocytes TBio-4101", "d": [], "t": []}, {"i": "NCIT:C191762", "l": "Autologous Tumor Infiltrating Lymphocytes TBio-4101", "d": ["A preparation of autologous tumor infiltrating lymphocytes (TILs) derived from each patient's resected tumor and expanded ex vivo, with potential immunomodulating and antineoplastic activities. Upon administration back into the patient, the autologous TILs TBio-4101 specifically recognize and kill the patient's tumor cells."], "t": []}], "preferred_name": "Autologous Tumor Infiltrating Lymphocytes TBio-4101", "taxa": []}
{"type": "biolink:Cell", "ic": 69.35521219301899, "identifiers": [{"i": "CL:0000080", "l": "circulating cell", "d": ["A cell which moves among different tissues of the body, via blood, lymph, or other medium."], "t": []}], "preferred_name": "circulating cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C4733630", "l": "Autologous Ovarian Cancer-specific Cytotoxic T-Lymphocytes", "d": [], "t": []}, {"i": "NCIT:C155664", "l": "Autologous Ovarian Cancer-specific Cytotoxic T-Lymphocytes", "d": ["A preparation of autologous cytotoxic T-lymphocytes (CTLs) genetically modified to target a not yet disclosed ovarian cancer-specific tumor-associated antigen (TAA), with potential immunomodulating and antineoplastic activities. After isolation, transduction, expansion in culture, and reintroduction into the patient, the autologous ovarian cancer-specific cytotoxic T-lymphocytes (OC-CTLs) bind to and induce selective toxicity in tumor cells expressing the TAA."], "t": []}], "preferred_name": "Autologous Ovarian Cancer-specific Cytotoxic T-Lymphocytes", "taxa": []}
{"type": "biolink:Cell", "ic": 79.07356789860069, "identifiers": [{"i": "UMLS:C1517544", "l": "Giant Epithelial Cell", "d": [], "t": []}, {"i": "NCIT:C36788", "l": "Giant Epithelial Cell", "d": [], "t": []}], "preferred_name": "Giant Epithelial Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4047005", "l": "cycling neuroblast (sensu Vertebrata)", "d": ["A(n) neuroblast (sensu Vertebrata) that is cycling."], "t": []}], "preferred_name": "cycling neuroblast (sensu Vertebrata)", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4323915", "l": "Set of trunk neural crest cells", "d": [], "t": []}], "preferred_name": "Set of trunk neural crest cells", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0546494", "l": "P.B. eosinophilic metamyelocyte", "d": [], "t": []}], "preferred_name": "P.B. eosinophilic metamyelocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 31.50515679062653, "identifiers": [{"i": "CL:0000540", "l": "neuron", "d": ["The basic cellular unit of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the nervous system."], "t": []}, {"i": "UMLS:C0027882", "l": "Neurons", "d": [], "t": []}, {"i": "NCIT:C12623", "l": "Neuron", "d": ["Any of the conducting cells of the nervous system. A typical neuron consists of a cell body, containing the nucleus and the surrounding cytoplasm (perikaryon); several short radiating processes (dendrites); and one long process (the axon), which terminates in twiglike branches (telodendrons) and may have branches (collaterals) projecting along its course."], "t": []}, {"i": "MESH:D009474", "l": "Neurons", "d": [], "t": []}, {"i": "SNOMEDCT:47220008", "l": "", "d": [], "t": []}], "preferred_name": "neuron", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0011024", "l": "double negative T regulatory cell", "d": ["A double negative thymocyte that is CD3-positive, CD4-negative, CD8-negative, that that are present in the periphery in very low numbers and predominantly produce INF-gamma, TNF-alpha, and a low amount of TGF-beta, but not IL-2, IL-4, IL-10 or IL-13 upon activation."], "t": []}], "preferred_name": "double negative T regulatory cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4023080", "l": "stellate L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (Mmus)", "d": ["a L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex that has stellate pyramidal morphology."], "t": []}], "preferred_name": "stellate L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (Mmus)", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5157526", "l": "CD3-CD57+ cells | Blood | Cell markers", "d": [], "t": []}], "preferred_name": "CD3-CD57+ cells | Blood | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": 90.871710685482, "identifiers": [{"i": "UMLS:C1708692", "l": "Leukemic Mast Cell", "d": [], "t": []}, {"i": "NCIT:C43274", "l": "Leukemic Mast Cell", "d": [], "t": []}], "preferred_name": "Leukemic Mast Cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5184819", "l": "Variant lymphocytes | Body fluid | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Variant lymphocytes | Body fluid | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C2348033", "l": "Cytomegalovirus pp65-Specific Cytotoxic T Lymphocytes", "d": [], "t": []}, {"i": "NCIT:C71747", "l": "Cytomegalovirus pp65-Specific Cytotoxic T Lymphocytes", "d": ["Cytotoxic T lymphocytes (CTLs) specifically reactive to the cytomegalovirus (CMV) phosphoprotein pp65 with potential antiviral activity. To prepare CMV pp65-specific cytotoxic T lymphocytes in vitro, dendritic cells (DCs) are pulsed with CMV pp65 epitopes and then used to stimulate and propagate CMV pp65-specific cytotoxic T lymphocytes from peripheral blood mononuclear cells (PBMNCs); the CMV pp65-specific cytotoxic T lymphocyte population is then expanded so as to be sufficient for use in adoptive T lymphocyte therapy. When administered into a patient post-allogeneic hematopoietic stem cell transplantation, this agent may elicit a specific CTL response against CMV-infected host cells, which may result in the resolution of CMV infection. The CMV pp65 protein (65 kDa lower matrix phosphoprotein), the primary component of the enveloped subviral particle, is an immunodominant target for helper and cytotoxic T lymphocyte responses to CMV."], "t": []}], "preferred_name": "Cytomegalovirus pp65-Specific Cytotoxic T Lymphocytes", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4543340", "l": "Spermatozoa component of semen", "d": [], "t": []}, {"i": "SNOMEDCT:734848001", "l": "", "d": [], "t": []}], "preferred_name": "Spermatozoa component of semen", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4079025", "l": "sacral dorsal root ganglion Piezo2 neuron", "d": ["A mechanosensitive sensory neuron whose soma is located in the sacral dorsal root ganglion and that expresses the mechanically activated ion channel Piezo2 (encoded by PIEZO2). This neuron transduces mechanical stimuli and is involved in light touch perception and proprioception. In human DRG, Piezo2-immunoreactive neurons constitute approximately 35% of TrkA-positive neurons, compared to 26% in mouse (Rostock et al. 2018, PMID:29229553). This subpopulation includes both low-threshold mechanoreceptors mediating innocuous touch and a subset of mechanically sensitive nociceptors, reflecting the dual role of Piezo2 in somatosensation across species."], "t": []}], "preferred_name": "sacral dorsal root ganglion Piezo2 neuron", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "MESH:D052939", "l": "Schizonts", "d": [], "t": []}], "preferred_name": "Schizonts", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "CL:0000966", "l": "Bm4 B cell", "d": ["A germinal center B cell that has the phenotype CD77-negative, IgD-negative, and CD38-positive. These cells have undergone somatic mutation of the B cell receptor."], "t": []}], "preferred_name": "Bm4 B cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1881196", "l": "Indium In 111-Labeled Autologous Polymorphonuclear Leukocytes", "d": [], "t": []}, {"i": "NCIT:C67086", "l": "Indium In 111-Labeled Autologous Polymorphonuclear Leukocytes", "d": ["A preparation of autologous peripheral polymorphonuclear (PMNLs) radiolabeled with indium In 111 with radioisotopic activity. Autologous PMNLs are isolated, expanded ex vivo, radiolabeled with indium In 111, and then infused back into the patient. Gamma scintigraphy may then be used to image gamma ray-emitting indium In 111 PMNLs localized in lymphoma tissue."], "t": []}], "preferred_name": "Indium In 111-Labeled Autologous Polymorphonuclear Leukocytes", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0228087", "l": "Macroglia", "d": [], "t": []}, {"i": "SNOMEDCT:45766003", "l": "", "d": [], "t": []}], "preferred_name": "Macroglia", "taxa": []}
{"type": "biolink:Cell", "ic": 48.633116255134134, "identifiers": [{"i": "CL:0000101", "l": "sensory neuron", "d": ["Any neuron having a sensory function; an afferent neuron conveying sensory impulses."], "t": []}, {"i": "UMLS:C0027883", "l": "Afferent neuron", "d": [], "t": []}, {"i": "NCIT:C12628", "l": "Sensory Neuron", "d": ["An afferent neuron that converts environmental stimuli into electrical impulses that are transmitted to the central nervous system."], "t": []}, {"i": "MESH:D009475", "l": "Neurons, Afferent", "d": [], "t": []}], "preferred_name": "sensory neuron", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5382905", "l": "HLA-A2 CMV specific CD8 cells | Blood | Cell markers", "d": [], "t": []}], "preferred_name": "HLA-A2 CMV specific CD8 cells | Blood | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1182628", "l": "Epithelial cell of anterior palatal part of viscerocranial mucosa", "d": [], "t": []}], "preferred_name": "Epithelial cell of anterior palatal part of viscerocranial mucosa", "taxa": []}
{"type": "biolink:Cell", "ic": 78.29800561113302, "identifiers": [{"i": "CL:0002607", "l": "migratory enteric neural crest cell", "d": ["A neural crest cell that gives rise to cells of the enteric nervous system."], "t": []}], "preferred_name": "migratory enteric neural crest cell", "taxa": []}
{"type": "biolink:Cell", "ic": 87.18682603146104, "identifiers": [{"i": "CL:4301611", "l": "commited oligodendrocyte precursor (Mmus)", "d": ["A committed oligodendrocyte precursor of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Gpr17 (Mmus), Bmp4 (Mmus). Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Supertype:1181 COP NN_1."], "t": []}], "preferred_name": "commited oligodendrocyte precursor (Mmus)", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4518163", "l": "Population of all abnormal spermatozoa in portion of fluid", "d": [], "t": []}, {"i": "SNOMEDCT:725221005", "l": "", "d": [], "t": []}], "preferred_name": "Population of all abnormal spermatozoa in portion of fluid", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0333846", "l": "Binucleated plasmablast", "d": [], "t": []}, {"i": "SNOMEDCT:11908008", "l": "", "d": [], "t": []}], "preferred_name": "Binucleated plasmablast", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1518169", "l": "Malignant Clear Cell Oncocyte", "d": [], "t": []}, {"i": "NCIT:C36940", "l": "Malignant Clear Cell Oncocyte", "d": [], "t": []}], "preferred_name": "Malignant Clear Cell Oncocyte", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5977367", "l": "CD3-CD14-CD45+CD56+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:1373219002", "l": "", "d": [], "t": []}], "preferred_name": "CD3-CD14-CD45+CD56+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "CL:0010010", "l": "cerebellar stellate cell", "d": ["A GABAergic interneuron that is located in the molecular layer of the cerebellum. This cell receives excitatory inputs primarily from parallel fibers and plays a crucial role in feed-forward inhibition by suppressing the activity of Purkinje cells and modulating the output of the cerebellar cortex. The stellate cell is part of the local circuitry that contributes to the fine-tuning of motor coordination and a regulator of cerebellar blood flow via neurovascular coupling."], "t": []}], "preferred_name": "cerebellar stellate cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5690235", "l": "Burr cells | Body fluid | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Burr cells | Body fluid | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4079004", "l": "cervical dorsal root ganglion peripherin neuron", "d": ["A small-diameter sensory neuron whose soma is located in the cervical dorsal root ganglion and that expresses peripherin (encoded by PRPH), a type III intermediate filament protein. This neuron is unmyelinated, conducts action potentials as a C-fiber, and encompasses nociceptive and thermoceptive functional subpopulations. In human DRG, peripherin-immunoreactive neurons are predominantly of small diameter (Chang et al. 2018, PMID:28424991), distinguishing them from large-diameter myelinated A-fiber neurons that instead express neurofilament heavy chain (Haberberger et al. 2019, PMID:31293388). In mice, peripherin similarly marks unmyelinated primary afferent neurons."], "t": []}], "preferred_name": "cervical dorsal root ganglion peripherin neuron", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0002235", "l": "luminal cell of prostatic acinus", "d": ["A cell of the luminal layer of the epithelium in the prostatic acinus."], "t": []}, {"i": "UMLS:C1183932", "l": "Luminal cell of prostatic acinus", "d": [], "t": []}], "preferred_name": "luminal cell of prostatic acinus", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5220604", "l": "Oval fat bodies (globules)|Urine/Urine sed", "d": [], "t": []}], "preferred_name": "Oval fat bodies (globules)|Urine/Urine sed", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0229424", "l": "Infantile diploetic mastoid cell", "d": [], "t": []}, {"i": "SNOMEDCT:87056002", "l": "", "d": [], "t": []}], "preferred_name": "Infantile diploetic mastoid cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4030057", "l": "eccentric medium spiny neuron", "d": ["A medium spiny neuron that exhibits transcriptional divergence from direct and indirect spiny projection neurons, for example, enrichment in Casz1, Otof, Cacng5 and Pcdh8 noted in mice. Whilst in general medium spiny neurons have been found to be differentially distributed across the basal ganglia, the eccentric medium spiny neuron cell type has been found to be more evenly distributed throughout cerebral nuclei."], "t": []}], "preferred_name": "eccentric medium spiny neuron", "taxa": []}
{"type": "biolink:Cell", "ic": 90.871710685482, "identifiers": [{"i": "UMLS:C1708893", "l": "Malignant Neuroectodermal Small Cell", "d": [], "t": []}, {"i": "NCIT:C54044", "l": "Malignant Neuroectodermal Small Cell", "d": [], "t": []}], "preferred_name": "Malignant Neuroectodermal Small Cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1440145", "l": "Blasts.CD20", "d": [], "t": []}], "preferred_name": "Blasts.CD20", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5203919", "l": "Autologous iC9-GD2CAR-CD28-CD3zeta-IL-15-expressing T-lymphocytes", "d": [], "t": []}, {"i": "NCIT:C158732", "l": "Autologous iC9-GD2CAR-CD28-CD3zeta-IL-15-expressing T-lymphocytes", "d": ["A preparation of autologous T-lymphocytes that have been transduced with the retroviral vector SFG, a Moloney murine leukemia (Mo-MuLV) virus-based vector, expressing both an extracellular domain consisting of interleukin 15 (IL-15) and a GD2-specific chimeric antigen receptor (CAR) derived from the monoclonal antibody 14G2a, linked to the CD28 and CD3zeta (TCRzeta; CD247) costimulatory signaling domains and containing the suicide gene, inducible caspase 9 (iCasp9 or iC9), with potential immunomodulating and antineoplastic activities. Upon administration, the autologous iC9-GD2CAR-CD28-CD3zeta-IL-15-expressing T-lymphocytes recognize, bind to and induce selective cytotoxicity in GD2-expressing tumor cells. IL-15 is a pro-survival cytokine that promotes T-cell persistence and potentiates the immune response against tumor cells. Incorporation of the costimulatory signaling domains increases T-cell function, expansion, and survival. The iCasp9 safety switch consists of a full-length caspase 9, including its caspase recruitment domain, linked to a human FK506 drug-binding domain with an F36V mutation (FKBP12-F36V). If the administered CAR T-cells lead to unacceptable side effects, the chemical homodimerizer AP1903, which binds to the FKBP12-F36V drug-binding domain, activates caspase 9 and results in apoptosis of the administered CAR T-cells, can be administered. GD2, a disialoganglioside and tumor-associated antigen (TAA), is overexpressed on the surface of neuroblastoma cells and other neuroectoderm-derived neoplasms and is minimally expressed on normal, healthy cells."], "t": []}], "preferred_name": "Autologous iC9-GD2CAR-CD28-CD3zeta-IL-15-expressing T-lymphocytes", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5855286", "l": "Besvatresgene Autoleucel", "d": [], "t": []}, {"i": "NCIT:C199004", "l": "Besvatresgene Autoleucel", "d": [], "t": []}], "preferred_name": "Besvatresgene Autoleucel", "taxa": []}
{"type": "biolink:Cell", "ic": 92.76600187037766, "identifiers": [{"i": "CL:0000925", "l": "activated CD4-positive type I NK T cell", "d": ["A type I NK T cell that has been recently activated, secretes interferon-gamma and IL-4, and has the phenotype CD4-positive, CD69-positive, and downregulated NK markers."], "t": []}], "preferred_name": "activated CD4-positive type I NK T cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4552764", "l": "Mesenchymal Progenitor Cell", "d": [], "t": []}], "preferred_name": "Mesenchymal Progenitor Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 82.62268137420203, "identifiers": [{"i": "CL:0002140", "l": "skin sebocyte", "d": ["An acinar cell that is part of a skin sebaceous gland. This cell produces and secretes sebum into hair follicles."], "t": []}, {"i": "UMLS:C1182779", "l": "Acinar cell of sebaceous gland", "d": [], "t": []}], "preferred_name": "skin sebocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5960035", "l": "Beretemcel", "d": [], "t": []}, {"i": "NCIT:C206882", "l": "Beretemcel", "d": [], "t": []}], "preferred_name": "Beretemcel", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5157498", "l": "CD34+CD117+ blasts | Bone marrow | Cell markers", "d": [], "t": []}], "preferred_name": "CD34+CD117+ blasts | Bone marrow | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4070013", "l": "ventricular dilator motor neuron", "d": ["A motor neuron that controls  ventral stomach grooves leading to pyloric filter."], "t": []}], "preferred_name": "ventricular dilator motor neuron", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1440237", "l": "CD105+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:725330004", "l": "", "d": [], "t": []}], "preferred_name": "CD105+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5169606", "l": "Irregularly contracted cells | Blood | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Irregularly contracted cells | Blood | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4267784", "l": "Cells.CD38+HLA-DR+", "d": [], "t": []}], "preferred_name": "Cells.CD38+HLA-DR+", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5154479", "l": "Basophils | Nose | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Basophils | Nose | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": 83.11065783093733, "identifiers": [{"i": "UMLS:C0524984", "l": "Somatostatin-Secreting Cells", "d": [], "t": []}, {"i": "NCIT:C12574", "l": "Delta Cell", "d": ["A somatostatin-producing cell found in the stomach, intestines, or pancreas."], "t": []}, {"i": "MESH:D019864", "l": "Somatostatin-Secreting Cells", "d": [], "t": []}], "preferred_name": "Somatostatin-Secreting Cells", "taxa": []}
{"type": "biolink:Cell", "ic": 76.78008365410358, "identifiers": [{"i": "CL:0002063", "l": "pulmonary alveolar type 2 cell", "d": ["A pulmonary alveolar epithelial cell that modulates the fluid surrounding the alveolar epithelium by secreting and recycling surfactants via specialized organelles called alveolar lamellar bodies. This cell type also contributes to tissue repair and can differentiate after injury into a pulmonary alveolar type 1 cell. This cuboidal cell is thicker than squamous alveolar cells, has a rounded apical surface that projects above the level of the surrounding epithelium, and its free surface is covered by short microvilli."], "t": []}], "preferred_name": "pulmonary alveolar type 2 cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5555768", "l": "CD8 Enriched Young Autologous Tumor-infiltrating Lymphocytes", "d": [], "t": []}, {"i": "NCIT:C179557", "l": "CD8 Enriched Young Autologous Tumor-infiltrating Lymphocytes", "d": ["A preparation of autologous young tumor infiltrating lymphocytes (TILs), that are isolated from the patient's tumor tissue that are CD8 enriched and expanded ex vivo, with potential antineoplastic and immunomodulating activities. Upon administration of the CD8 enriched young autologous TILs, the TILs re-infiltrate the tumor, recognize the tumor cells and initiate tumor cell lysis. This inhibits tumor cell growth."], "t": []}], "preferred_name": "CD8 Enriched Young Autologous Tumor-infiltrating Lymphocytes", "taxa": []}
{"type": "biolink:Cell", "ic": 90.871710685482, "identifiers": [{"i": "UMLS:C1513990", "l": "Neoplastic Immunoblast-Like B-Lymphocyte", "d": [], "t": []}, {"i": "NCIT:C38657", "l": "Neoplastic Immunoblast-Like B-Lymphocyte", "d": [], "t": []}], "preferred_name": "Neoplastic Immunoblast-Like B-Lymphocyte", "taxa": []}
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{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4521533", "l": "Donor lymphocytes for infusion (specimen)", "d": [], "t": []}, {"i": "SNOMEDCT:456891000124106", "l": "", "d": [], "t": []}], "preferred_name": "Donor lymphocytes for infusion (specimen)", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5708040", "l": "Autologous Anti-GD2/Anti-PSMA 4SCAR-expressing Bispecific T-cells", "d": [], "t": []}, {"i": "NCIT:C188800", "l": "Autologous Anti-GD2/Anti-PSMA 4SCAR-expressing Bispecific T-cells", "d": ["A preparation of autologous T-lymphocytes that are genetically engineered to express a fourth-generation chimeric antigen receptor (4SCAR) targeting the two tumor-associated antigens (TAAs) disialoganglioside (GD2) and prostate-specific membrane antigen (PSMA), with potential immunostimulating and antineoplastic activities. Upon administration, the autologous anti-GD2/anti-PSMA 4SCAR-expressing bispecific T-cells are directed to and induce selective toxicity in GD2- and PSMA-expressing tumor cells. GD2 is overexpressed on the surface of neuroblastoma (NB) cells and by other neuroectoderm-derived neoplasms, while it is minimally expressed on normal cells. PSMA, a type II transmembrane protein, is expressed on the membrane of prostatic epithelial cells and overexpressed on prostate tumor cells as well as a variety of other solid tumors, including brain tumor, NB and some lymphoma tumor tissues."], "t": []}], "preferred_name": "Autologous Anti-GD2/Anti-PSMA 4SCAR-expressing Bispecific T-cells", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4052014", "l": "pancreatic islet capillary endothelial cell", "d": ["A capillary endothelial cell that is part of islet of Langerhans, characterized by a high density of fenestrations —approximately ten times greater than those in exocrine pancreatic capillaries. These fenestrations facilitate efficient hormone exchange, which is essential for maintaining glucose homeostasis. The cell's structure and function are regulated by the local production of vascular endothelial growth factor-A (VEGF-A), which maintains its fenestrated architecture."], "t": []}], "preferred_name": "pancreatic islet capillary endothelial cell", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "UMLS:C2985477", "l": "Exocrine Pancreas Cell", "d": [], "t": []}, {"i": "NCIT:C93173", "l": "Exocrine Pancreas Cell", "d": ["A pancreatic cell which either secretes digestive enzymes (acinar cell) or bicarbonate-rich fluid (ductal cell) via the pancreatic duct into the duodenum to assist in digestion."], "t": []}], "preferred_name": "Exocrine Pancreas Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 81.34422831136257, "identifiers": [{"i": "CL:0000797", "l": "alpha-beta intraepithelial T cell", "d": ["A mature alpha-beta T cell of the columnar epithelium of the gastrointestinal tract. Intraepithelial T cells often have distinct developmental pathways and activation requirements."], "t": []}], "preferred_name": "alpha-beta intraepithelial T cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4072008", "l": "A11 dopaminergic neuron", "d": ["A type of hypothalamic dopaminergic neuron found in the posterior hypothalamus, projecting to the spinal cord where it modulates pain, motor activity (Koblinger et al., 2014), and somatosensory processing (Zhang et a., 2023)."], "t": []}], "preferred_name": "A11 dopaminergic neuron", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4310125", "l": "STR TAC3-PLPP4 GABA TAC3-positive striatal interneuron (Primate)", "d": ["A TAC3-positive striatal interneuron of the Primates brain. These cells are located in the striatum . Reference transcriptomic data for this type can be found in the dataset/taxonomy - HMBA Basal Ganglia Consensus Taxonomy in cell set Group:STR TAC3-PLPP4 GABA."], "t": []}], "preferred_name": "STR TAC3-PLPP4 GABA TAC3-positive striatal interneuron (Primate)", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5419238", "l": "Atleradstrocel", "d": [], "t": []}, {"i": "NCIT:C171651", "l": "Atleradstrocel", "d": [], "t": []}], "preferred_name": "Atleradstrocel", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C3827116", "l": "EXPANDED UMBILICAL CORD BLOOD PRODUCT HSC835", "d": [], "t": []}], "preferred_name": "EXPANDED UMBILICAL CORD BLOOD PRODUCT HSC835", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4033128", "l": "celiac ganglion VIP neuron", "d": ["A sympathetic neuron that has the soma located in the celiac ganglion and expresses the marker vasoactive intestinal peptide (VIP)."], "t": []}], "preferred_name": "celiac ganglion VIP neuron", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5575456", "l": "Autologous Anti-glypican-3 CAR-IL-15-iC9-expressing T-lymphocytes", "d": [], "t": []}, {"i": "NCIT:C185176", "l": "Autologous Anti-glypican-3 CAR-IL-15-iC9-expressing T-lymphocytes", "d": ["A preparation of T-lymphocytes that have been genetically modified to express a chimeric antigen receptor (CAR) specific for glypican-3 (GPC3) and express interleukin-15 (IL-15) and the suicide gene, inducible caspase 9 (iCasp9 or iC9), with potential immunostimulating and antineoplastic activities. Upon administration, anti-GPC3-CAR-IL-15-iC9-expressing T-lymphocytes specifically target and bind to GPC3-expressing tumor cells, resulting in tumor cell lysis. GPC3, a heparan sulfate proteoglycan and a member of the glypican family, is overexpressed on certain tumor cell types while minimally expressed on normal, healthy cells; GPC3 plays an important role in cellular proliferation and differentiation. IL-15 is a pro-survival cytokine that potentiates, in addition to promoting T-cell proliferation and persistence, the immune response against tumor cells. The iCasp9 safety switch consists of a full-length caspase 9, including its caspase recruitment domain, linked to a human FK506 drug-binding domain with an F36V mutation (FKBP12-F36V). If the administered CAR T-cells lead to unacceptable side effects, the chemical homodimerizer AP1903 can be administered. AP1903 binds to the FKBP12-F36V drug-binding domain, activates caspase 9 and results in apoptosis of the administered CAR T-cells."], "t": []}], "preferred_name": "Autologous Anti-glypican-3 CAR-IL-15-iC9-expressing T-lymphocytes", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5157282", "l": "CD123 blasts | Blood | Cell markers", "d": [], "t": []}], "preferred_name": "CD123 blasts | Blood | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": 77.82747199602274, "identifiers": [{"i": "CL:1001599", "l": "pancreas exocrine glandular cell", "d": ["Glandular cell of exocrine pancreas epithelium. Example: pancreatic acinar cell, glandular cells in pancreatic canaliculi, glandular cells in pancreatic ducts."], "t": []}], "preferred_name": "pancreas exocrine glandular cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C0079852", "l": "Monocytes, Activated Killer", "d": [], "t": []}, {"i": "NCIT:C12548", "l": "Monocyte, Activated Killer", "d": ["A monocyte that has been activated for cytotoxicity by gamma interferon."], "t": []}, {"i": "MESH:D016260", "l": "Monocytes, Activated Killer", "d": [], "t": []}], "preferred_name": "Monocytes, Activated Killer", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1531511", "l": "", "d": [], "t": []}], "preferred_name": "", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5155171", "l": "Blasts | Pleural fluid | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Blasts | Pleural fluid | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0004218", "l": "H2 horizontal cell", "d": ["A horizontal cell with a small cell body, thin dendrites, and small dendritic arbor."], "t": []}, {"i": "UMLS:C2324017", "l": "H II cell of retina", "d": [], "t": []}], "preferred_name": "H2 horizontal cell", "taxa": []}
{"type": "biolink:Cell", "ic": 92.76600187037766, "identifiers": [{"i": "CL:0000774", "l": "band form eosinophil", "d": ["A late eosinophilic metamyelocyte in which the nucleus is in the form of a curved or coiled band, not having acquired the typical multilobar shape of the mature eosinophil."], "t": []}], "preferred_name": "band form eosinophil", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5157299", "l": "CD13+CD33+ cells | Blood | Cell markers", "d": [], "t": []}], "preferred_name": "CD13+CD33+ cells | Blood | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5761765", "l": "Activated natural killer cell therapy", "d": [], "t": []}], "preferred_name": "Activated natural killer cell therapy", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5907928", "l": "Allogeneic CD19/CD20-specific CAR-T Cells P-CD19CD20-ALLO1", "d": [], "t": []}, {"i": "NCIT:C201791", "l": "Allogeneic CD19/CD20-specific CAR-T Cells P-CD19CD20-ALLO1", "d": ["An off-the-shelf (OTS) preparation of human allogeneic T-lymphocytes containing primarily stem cell memory T-cells (Tscm) that have been genetically modified to express two chimeric antigen receptors (CARs) targeting the tumor-associated antigens (TAAs) CD19 and CD20, with potential immunostimulating and antineoplastic activities. Upon administration, allogeneic CD19/CD20-specific CAR-T cells P-CD19CD20-ALLO1 specifically recognize and induce selective toxicity in CD19- and/or CD20-expressing tumor cells. Both CD19 and CD20 are B-cell-specific cell surface antigens overexpressed in B-cell lineage malignancies. Targeting both CD19 and CD20 may prevent tumor cell antigen escape and relapse."], "t": []}], "preferred_name": "Allogeneic CD19/CD20-specific CAR-T Cells P-CD19CD20-ALLO1", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4070011", "l": "lateral gastric neuron", "d": ["A motor neuron that closes the lateral teeth."], "t": []}], "preferred_name": "lateral gastric neuron", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C2930256", "l": "", "d": [], "t": []}], "preferred_name": "", "taxa": []}
{"type": "biolink:Cell", "ic": 92.76600187037766, "identifiers": [{"i": "CL:0000963", "l": "Bm3-delta B cell", "d": ["A germinal center B cell that develops from a Bm3 B cell. This cell has the phenotype IgM-negative, IgD-positive, and CD38-positive."], "t": []}], "preferred_name": "Bm3-delta B cell", "taxa": []}
{"type": "biolink:Cell", "ic": 49.53590604531774, "identifiers": [{"i": "CL:0000134", "l": "mesenchymal stem cell", "d": ["A connective tissue cell that normally gives rise to other cells that are organized as three-dimensional masses. In humans, this cell type is CD73-positive, CD90-positive, CD105-positive, CD45-negative, CD34-negative, and MHCII-negative. They may further differentiate into osteoblasts, adipocytes, myocytes, neurons, or chondroblasts in vitro. Originally described as residing in the bone marrow, this cell type is now known to reside in many, if not all, adult organs."], "t": []}, {"i": "UMLS:C1257975", "l": "Mesenchymal Stem Cells", "d": [], "t": []}, {"i": "NCIT:C43423", "l": "Mesenchymal Stem Cell", "d": ["An undifferentiated stromal cell with the ability to develop into the cells that form distinct mesenchymal tissues; such as bone, muscle, connective tissue, blood vessels, and lymphatic tissue."], "t": []}, {"i": "MESH:D059630", "l": "Mesenchymal Stem Cells", "d": [], "t": []}, {"i": "SNOMEDCT:418124002", "l": "", "d": [], "t": []}], "preferred_name": "mesenchymal stem cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C3282339", "l": "Cells, Cultured, Allogeneic", "d": [], "t": []}], "preferred_name": "Cells, Cultured, Allogeneic", "taxa": []}
{"type": "biolink:Cell", "ic": 47.974484878975574, "identifiers": [{"i": "CL:0000226", "l": "single nucleate cell", "d": ["A cell with a single nucleus."], "t": []}], "preferred_name": "single nucleate cell", "taxa": []}
{"type": "biolink:Cell", "ic": 74.78966420922332, "identifiers": [{"i": "CL:0001031", "l": "cerebellar granule cell", "d": ["An excitatory granule cell with a soma located in the granular layer of cerebellar cortex. A mature cerebellar granule cell has short dendrites with a characteristic claw-like appearance and a long axon that ascends to the molecular layer where it bifurcates (except in non-teleost fish, where it does not bifurcate) and extends mediolaterally to form parallel fibers."], "t": []}], "preferred_name": "cerebellar granule cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C2334115", "l": "Set of Ch2 cholinergic cells", "d": [], "t": []}], "preferred_name": "Set of Ch2 cholinergic cells", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1440309", "l": "CD42b+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:1372887009", "l": "", "d": [], "t": []}], "preferred_name": "CD42b+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5216310", "l": "Granulocytes|NCnc|Pt|Body fld", "d": [], "t": []}], "preferred_name": "Granulocytes|NCnc|Pt|Body fld", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "UMLS:C1513741", "l": "Multilobated Lipoblast-Like Cell", "d": [], "t": []}, {"i": "NCIT:C36971", "l": "Multilobated Lipoblast-Like Cell", "d": [], "t": []}], "preferred_name": "Multilobated Lipoblast-Like Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 79.9528279018387, "identifiers": [{"i": "UMLS:C5856677", "l": "Anti-mesothelin CAR T Cells Preparation", "d": [], "t": []}, {"i": "NCIT:C201275", "l": "Anti-mesothelin CAR T Cells Preparation", "d": ["Any preparation of chimeric antigen receptor (CAR)-expressing T-lymphocytes that targets the tumor-associated antigen (TAA) mesothelin (MSLN)."], "t": []}], "preferred_name": "Anti-mesothelin CAR T Cells Preparation", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5163553", "l": "Epithelial cells.renal | Urine sediment | Urinalysis", "d": [], "t": []}], "preferred_name": "Epithelial cells.renal | Urine sediment | Urinalysis", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C6051118", "l": "Autologous Tumor Infilitrating Lymphocytes Hema-NeoTIL01", "d": [], "t": []}, {"i": "NCIT:C217330", "l": "Autologous Tumor Infilitrating Lymphocytes Hema-NeoTIL01", "d": ["A preparation of autologous tumor infiltrating lymphocytes (TILs) derived from a patient's bone marrow or peripheral blood and expanded ex vivo through antigen presentation, with potential immunomodulating and antineoplastic activities. Upon administration back into the patient, the autologous TILs Hema-NeoTIL01 specifically recognize and kill the patient's tumor cells."], "t": []}], "preferred_name": "Autologous Tumor Infilitrating Lymphocytes Hema-NeoTIL01", "taxa": []}
{"type": "biolink:Cell", "ic": 75.876659701315, "identifiers": [{"i": "UMLS:C1518238", "l": "Malignant Perineural Cell", "d": [], "t": []}, {"i": "NCIT:C41434", "l": "Malignant Perineural Cell", "d": [], "t": []}], "preferred_name": "Malignant Perineural Cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1440332", "l": "Cells.CD53", "d": [], "t": []}], "preferred_name": "Cells.CD53", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C3896829", "l": "axicabtagene ciloleucel", "d": [], "t": []}, {"i": "MESH:C000629083", "l": "axicabtagene ciloleucel", "d": [], "t": []}, {"i": "SNOMEDCT:764088001", "l": "", "d": [], "t": []}, {"i": "SNOMEDCT:764116009", "l": "", "d": [], "t": []}], "preferred_name": "axicabtagene ciloleucel", "taxa": []}
{"type": "biolink:Cell", "ic": 57.19116033752107, "identifiers": [{"i": "UMLS:C1511246", "l": "Bone marrow stem cell", "d": [], "t": []}, {"i": "NCIT:C13456", "l": "Bone Marrow Stem Cell", "d": ["A hematopoietic stem cell found in the bone marrow."], "t": []}], "preferred_name": "Bone marrow stem cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C3495988", "l": "A2 noradrenaline cells", "d": [], "t": []}], "preferred_name": "A2 noradrenaline cells", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4079011", "l": "lumbar dorsal root ganglion CGRP neuron", "d": ["A peptidergic nociceptor whose soma is located in the lumbar dorsal root ganglion, characterized by expression of calcitonin gene-related peptide (CGRP, encoded by CALCA). This small- to medium-diameter neuron belongs to the TrkA-positive peptidergic subpopulation and typically co-expresses substance P. It innervates peripheral tissues including skin and viscera, where it mediates neurogenic inflammation and nociceptive signalling through release of CGRP from peripheral terminals during tissue injury (Haberberger et al. 2019, PMID:31293388). In human DRG, CGRP-immunoreactive neurons represent a substantial proportion of nociceptors, comparable to the pattern observed in rodents (Rostock et al. 2018, PMID:29229553)."], "t": []}], "preferred_name": "lumbar dorsal root ganglion CGRP neuron", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1512636", "l": "Immature Myxoid Mesenchymal Cell", "d": [], "t": []}, {"i": "NCIT:C37119", "l": "Immature Myxoid Mesenchymal Cell", "d": [], "t": []}], "preferred_name": "Immature Myxoid Mesenchymal Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:1000804", "l": "kidney outer medulla interstitial cell", "d": ["A kidney cell that is part of an interstitial compartment of an outer renal medulla."], "t": []}], "preferred_name": "kidney outer medulla interstitial cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5667072", "l": "CYNK-101", "d": [], "t": []}, {"i": "NCIT:C186655", "l": "Allogeneic CD16-expressing Natural Killer Cells CYNK-101", "d": ["A population of cryopreserved, off-the-shelf (OTS) allogeneic natural killer (NK) cells derived from human placental hematopoietic stem cells (HSCs) expressing the CD34 surface antigen, and engineered to express a high-affinity, non-cleavable CD16 (hnCD16) Fc receptor, with potential antineoplastic and immunostimulatory activities. Upon infusion of CYNK-101, the allogeneic CD16-expressing NK cells bind to the Fc portion of tumor cell-bound monoclonal antibodies that were administered as induction therapy. This enhances NK cell activation, cytokine secretion, and antibody-dependent cellular cytotoxicity (ADCC) in the presence of certain antibody therapeutics. CD16, also known as Fc-gamma receptor III, is normally expressed on the surface of NK cells, neutrophils, monocytes and macrophages, and plays a key role in initiating ADCC. It is often downregulated in certain cancers, thereby inhibiting the anti-tumor immune response. CYNK-101 NK cells' hnCD16 Fc receptor prevents downregulation and optimizes binding to tumor-targeting antibodies for enhanced ADCC."], "t": []}], "preferred_name": "CYNK-101", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5787069", "l": "Allogeneic Rituximab Conjugated Gamma Delta T-cells ACE1831", "d": [], "t": []}, {"i": "NCIT:C198411", "l": "Allogeneic Rituximab Conjugated Gamma Delta T-cells ACE1831", "d": ["An off-the-shelf preparation of a subset of allogeneic T-lymphocytes that express only gamma chain and delta chain T-cell receptors (TCRs) conjugated to a DNA linker, attached via DNA hybridization to rituximab conjugated to another DNA linker, with potential immunomodulating and antineoplastic activities. Upon administration of the allogeneic rituximab conjugated gamma delta T-cells ACE1831, rituximab targets and binds to CD20 expressed on tumor cells. The gamma delta T-cells secrete interferon-gamma (IFN-g) and exert direct killing of the CD20-expressing tumor cells. In addition, these cells activate the immune system to exert a cytotoxic T-lymphocyte (CTL) response against CD20-expressing tumor cells. Gamma delta T-lymphocytes play a key role in the activation of the immune system and do not require major histocompatibility complex (MHC)-mediated antigen presentation to exert their cytotoxic effect. The CD20 antigen, a non-glycosylated cell surface phosphoprotein, is a B-cell specific cell surface antigen overexpressed in B-cell lineage malignancies."], "t": []}], "preferred_name": "Allogeneic Rituximab Conjugated Gamma Delta T-cells ACE1831", "taxa": []}
{"type": "biolink:Cell", "ic": 92.76600187037766, "identifiers": [{"i": "CL:4301595", "l": "Astro-TE NN_5 astrocyte (Mmus)", "d": ["A astrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Gja1 (Mmus), Thbs4 (Mmus), Kcnk10 (Mmus), Pak1 (Mmus). Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Supertype:1165 Astro-TE NN_5."], "t": []}], "preferred_name": "Astro-TE NN_5 astrocyte (Mmus)", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5184397", "l": "Unidentified cells | Cerebral spinal fluid | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Unidentified cells | Cerebral spinal fluid | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5962695", "l": "Allogeneic Anti-CD5 CAR-CD28zeta T-lymphocytes", "d": [], "t": []}], "preferred_name": "Allogeneic Anti-CD5 CAR-CD28zeta T-lymphocytes", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4070016", "l": "anterior burster neuron", "d": ["Pyloric pacemaker neuron that provides feedback to commissural ganglia (CoG) neurons."], "t": []}], "preferred_name": "anterior burster neuron", "taxa": []}
{"type": "biolink:Cell", "ic": 73.98236851641934, "identifiers": [{"i": "CL:0000748", "l": "retinal bipolar neuron", "d": ["A bipolar neuron found in the retina and having connections with photoreceptors cells and neurons in the inner plexiform layer."], "t": []}, {"i": "UMLS:C1564995", "l": "Retinal Bipolar Cells", "d": [], "t": []}, {"i": "MESH:D051245", "l": "Retinal Bipolar Cells", "d": [], "t": []}, {"i": "SNOMEDCT:72060002", "l": "", "d": [], "t": []}], "preferred_name": "retinal bipolar neuron", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C3273372", "l": "CD4 Positive Naive T-Lymphocyte", "d": [], "t": []}, {"i": "NCIT:C97350", "l": "CD4 Positive Naive T-Lymphocyte", "d": ["A T lymphocyte that has differentiated in the bone marrow, undergone central selection in the thymus, but has not encountered its cognate antigen in the peripheral circulation. These cells can be identified by presence of both the CD4 and CD45RA molecules on their surface."], "t": []}], "preferred_name": "CD4 Positive Naive T-Lymphocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5446421", "l": "ET140203", "d": [], "t": []}, {"i": "NCIT:C175306", "l": "Autologous Anti-HLA-A*02/AFP TCRm-expressing T-cells ET140203", "d": ["A preparation of autologous T-lymphocytes that have been transduced with a lentiviral vector to express a T-cell receptor mimetic (TCRm) construct targeting the immunogenetic human tumor-associated antigen (TAA) alpha-fetoprotein (AFP) complexed with human leukocyte antigen (HLA)-A*02 (HLA-A*02/AFP), with potential immunomodulatory and antineoplastic activities. Upon administration, autologous anti-HLA-A*02/AFP TCRm-expressing T-cells ET140203 specifically recognize and selectively bind to AFP peptides presented by HLA-A*02. This results in cytotoxic T-lymphocyte (CTL)-mediated elimination of AFP-expressing tumor cells. AFP, an intracellularly expressed fetal glycoprotein rarely expressed in adult tissues, is overexpressed in certain tumors of endodermal origin and plays a key role in tumor cell proliferation and survival. AFP is processed into peptides and presented by class I major histocompatibility complexes (MHCs) on the surface of tumor cells."], "t": []}], "preferred_name": "ET140203", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C3178739", "l": "Effector B Cells", "d": [], "t": []}], "preferred_name": "Effector B Cells", "taxa": []}
{"type": "biolink:Cell", "ic": 86.30756602822301, "identifiers": [{"i": "CL:0000751", "l": "rod bipolar cell", "d": ["A bipolar neuron found in the retina that is synapsed by rod photoreceptor cells but not by cone photoreceptor cells.  These neurons depolarize in response to light."], "t": []}, {"i": "UMLS:C2327673", "l": "Rod bipolar cell", "d": [], "t": []}], "preferred_name": "rod bipolar cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0228129", "l": "Outer mesothelial cell", "d": [], "t": []}, {"i": "SNOMEDCT:90459004", "l": "", "d": [], "t": []}], "preferred_name": "Outer mesothelial cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1514891", "l": "Reserve Stem Cell", "d": [], "t": []}, {"i": "NCIT:C33464", "l": "Reserve Stem Cell", "d": [], "t": []}], "preferred_name": "Reserve Stem Cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1648296", "l": "CD38+kappa+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:1376046007", "l": "", "d": [], "t": []}], "preferred_name": "CD38+kappa+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": 75.54735764213513, "identifiers": [{"i": "CL:0000351", "l": "trophoblast cell", "d": ["An extraembryonic cell that develops from a trophectodermal cell. This cell is found in the outer layer of the blastocyst and can invade other structures in the uterus once the blastocyst implants into the uterine wall. A trophoblast cell is involved in the implantation of the embryo into the uterine wall, placental formation, remodelling of maternal vasculature in the uterus, nutrient and gas exchange, hormone production, and immune modulation to support fetal development."], "t": []}, {"i": "UMLS:C1519658", "l": "Trophoblast cell", "d": [], "t": []}, {"i": "NCIT:C33917", "l": "Trophoblastic Cell", "d": ["A cell from the outside layer of tissue on the blastocyte, a hollow ball of cells formed in the early development of an embryo. It attaches the blastocyte to the endometrium of the uterus and supplies nourishment to the embryo. The chorion and amnion are derived from these cells."], "t": []}], "preferred_name": "trophoblast cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5163556", "l": "Epithelial cells.squamous | Sputum | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Epithelial cells.squamous | Sputum | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5380993", "l": "Cells.CD8.HLA-B35 CMV specific.CMV antigen stimulated gamma interferon producing", "d": [], "t": []}], "preferred_name": "Cells.CD8.HLA-B35 CMV specific.CMV antigen stimulated gamma interferon producing", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4038423", "l": "cervical cells", "d": [], "t": []}], "preferred_name": "cervical cells", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1268459", "l": "FMC-7+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:116831005", "l": "", "d": [], "t": []}], "preferred_name": "FMC-7+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1267800", "l": "CYCD79+ lymphocyte", "d": [], "t": []}, {"i": "SNOMEDCT:117504009", "l": "", "d": [], "t": []}], "preferred_name": "CYCD79+ lymphocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0002263", "l": "transitional cell of parathyroid gland", "d": ["One of three types of epithelial cells that populate the parathyroid gland; cytological characteristics intermediate between those of the chief cell and of the oxyphil cell. Because only one hormone is produced, the three cell forms are widely believed to be different phases in the life cycle of a single cell type, with the chief cell being its physiologically active stage."], "t": []}, {"i": "UMLS:C0229587", "l": "Structure of parathyroid transitional cell", "d": [], "t": []}, {"i": "SNOMEDCT:15824004", "l": "", "d": [], "t": []}], "preferred_name": "transitional cell of parathyroid gland", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1440422", "l": "TCR gamma delta+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:1376055005", "l": "", "d": [], "t": []}], "preferred_name": "TCR gamma delta+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5557201", "l": "NY-ESO-1-expressing Artificial Adjuvant Vector Cells ASP0739", "d": [], "t": []}, {"i": "NCIT:C181663", "l": "NY-ESO-1-expressing Artificial Adjuvant Vector Cells ASP0739", "d": ["A preparation of artificial adjuvant vector cells (aAVCs) composed of modified human cells engineered to express the tumor-associated antigen (TAA) New York esophageal squamous cell carcinoma 1 (NY-ESO-1) and loaded with loaded with the cluster of differentiation 1d (CD1d) ligand alpha-galactosylceramide (alpha-GalCer; a-GalCer), with potential immunostimulating and antineoplastic activities. Upon administration of the NY-ESO-1-expressing aAVCs ASP0739, the presentation of α-GalCer by CD1d molecules on the cell surface activates invariant NKT (iNKT) cells, thereby eliciting NY-ESO-1-specific NKT cell responses against ASP0739. This in turn activates a natural killer (NK) cell response against NY-ESO-1-expressing tumor cells. In turn, the NY-ESO-1 released from destroyed ASP0739 is taken up by antigen-presenting cells (APCs), mainly by dendritic cells (DCs), which in turn activates NY-ESO-1-specific cytotoxic T-lymphocytes (CTL) and results in a CTL-mediated immune response against NY-ESO-1-expressing tumor cells, thereby further destroying NY-ESO-1-expressing tumor cells. In addition, the activation of antigen-specific memory T cells provides long-lasting anti-tumor effects against the NY-ESO-1-expressing tumor cells."], "t": []}], "preferred_name": "NY-ESO-1-expressing Artificial Adjuvant Vector Cells ASP0739", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0003026", "l": "retinal ganglion cell D1", "d": ["A bistratified retinal ganglion cell that has a small dendrite fields with a sparse dendrite arbor terminating in S2 and S3."], "t": []}], "preferred_name": "retinal ganglion cell D1", "taxa": []}
{"type": "biolink:Cell", "ic": 69.48184434309724, "identifiers": [{"i": "CL:0000068", "l": "duct epithelial cell", "d": ["An epithelial cell that is part of a duct."], "t": []}], "preferred_name": "duct epithelial cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5909068", "l": "Cenzileucel", "d": [], "t": []}, {"i": "NCIT:C203191", "l": "Cenzileucel", "d": [], "t": []}], "preferred_name": "Cenzileucel", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5419630", "l": "LMP2-specific T Cell Receptor-transduced Autologous T-lymphocytes", "d": [], "t": []}, {"i": "NCIT:C172395", "l": "LMP2-specific T Cell Receptor-transduced Autologous T-lymphocytes", "d": ["A preparation of autologous T-lymphocytes that have been transduced with a lentiviral vector encoding a T-cell receptor (TCR) specific for human leukocyte antigen (HLA)-A02:01/24:02/11:01-restricted Epstein-Barr virus (EBV) latent membrane proteins (LMP) 1 and 2, and EBV nuclear antigen 1 (EBNA1), with potential antineoplastic activity. Upon administration, the autologous LMP1/LMP2/EBNA1-specific, HLA-A02:01/24:02/11:01-restricted TCR-expressing T-lymphocytes YT-E001 recognize and bind to HLA-presented EBV peptides, which may promote cell death and inhibit the growth of tumor cells expressing LMP1, LMP2 or EBNA1. LMP1, LMP2, and EBNA1 are expressed in various, EBV-associated malignancies, including nasopharyngeal cancer and EBV-positive Hodgkin lymphoma."], "t": []}], "preferred_name": "LMP2-specific T Cell Receptor-transduced Autologous T-lymphocytes", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0002273", "l": "type ECL enteroendocrine cell", "d": ["A type EC enteroendocrine cell type that is numerous in the fundus of the stomach; stores 5-hydroxytryptamine and histamine."], "t": []}, {"i": "UMLS:C2327855", "l": "Type ECL enteroendocrine cell", "d": [], "t": []}], "preferred_name": "type ECL enteroendocrine cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C4725079", "l": "Autologous PSMA-specific TGFb-resistant CAR T Cells", "d": [], "t": []}, {"i": "NCIT:C148496", "l": "Autologous PSMA-specific TGFb-resistant CAR T Cells", "d": ["Autologous T-lymphocytes transduced with a lentiviral vector expressing a chimeric antigen receptor (CAR) consisting of an anti-prostate specific membrane antigen (PSMA) single chain variable fragment (scFv) and expressing a dominant negative (DN) form of transforming growth factor-beta (TGF-beta; TGFb) receptor, with potential immunomodulating and antineoplastic activities. Upon transfusion, the autologous PSMA-specific TGFb-resistant CAR T cells are directed to and induce selective toxicity in PSMA-expressing tumor cells. The tumor-associated antigen (TAA) PSMA is overexpressed by prostate cancers; its expression is associated with poor prognosis and metastasis. The inclusion of the DN TGFb receptor blocks signaling of the immunosuppressive cytokine TGFb in the tumor microenvironment (TME) and makes the CAR T cells resistant to TGFb. TGFb negatively regulates T-cell proliferation and activation and plays a key role in tumor immune suppression."], "t": []}], "preferred_name": "Autologous PSMA-specific TGFb-resistant CAR T Cells", "taxa": []}
{"type": "biolink:Cell", "ic": 90.871710685482, "identifiers": [{"i": "CL:0002039", "l": "immature NK T cell stage I, mouse", "d": ["A CD24-high, CD4-low, CD8-low, CD44-negative, NK1.1-negative NK T cell."], "t": []}], "preferred_name": "immature NK T cell stage I, mouse", "taxa": []}
{"type": "biolink:Cell", "ic": 73.04009684703995, "identifiers": [{"i": "UMLS:C1879555", "l": "Adenocarcinoma Cell with Eosinophilic Cytoplasm", "d": [], "t": []}, {"i": "NCIT:C61145", "l": "Adenocarcinoma Cell with Eosinophilic Cytoplasm", "d": [], "t": []}], "preferred_name": "Adenocarcinoma Cell with Eosinophilic Cytoplasm", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0000758", "l": "type 6 cone bipolar cell (sensu Mus)", "d": ["An ON-bipolar neuron found in the retina and having connections with cone photoreceptors cells and neurons in the inner half of the inner plexiform layer. The cell has a loose, delicate axon terminal that opens in sublamina 3 of the inner plexiform layer and descends into sublamina 4."], "t": []}], "preferred_name": "type 6 cone bipolar cell (sensu Mus)", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5418366", "l": "Elivaldogene tavalentivec", "d": [], "t": []}, {"i": "NCIT:C169938", "l": "Elivaldogene Tavalentivec", "d": [], "t": []}], "preferred_name": "Elivaldogene tavalentivec", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C2327104", "l": "Velate protoplasmic astrocyte", "d": [], "t": []}], "preferred_name": "Velate protoplasmic astrocyte", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0314591", "l": "Colony-forming unit of lymphoid-myeloid lineage", "d": [], "t": []}, {"i": "SNOMEDCT:444995008", "l": "", "d": [], "t": []}], "preferred_name": "Colony-forming unit of lymphoid-myeloid lineage", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1267950", "l": "Lymphocyte positive for CD58 antigen", "d": [], "t": []}, {"i": "SNOMEDCT:117391008", "l": "", "d": [], "t": []}], "preferred_name": "Lymphocyte positive for CD58 antigen", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5216284", "l": "Myelocytes|NCnc|Pt|Body fld", "d": [], "t": []}], "preferred_name": "Myelocytes|NCnc|Pt|Body fld", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5157432", "l": "CD3+CD25+ cells | Tissue and Smears | Cell markers", "d": [], "t": []}], "preferred_name": "CD3+CD25+ cells | Tissue and Smears | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "CL:0002651", "l": "endothelial cell of venous sinus of spleen", "d": ["An endothelial cell that is part of the venous sinus of spleen. This endothelial cell has an elongated, spindle-shaped, flattened morphology that is parallel to long axis of sinus. This cell type rests on a basement membrane interrupted by numerous narrow slits."], "t": []}, {"i": "UMLS:C1183324", "l": "Endothelial cell of venous sinusoid of spleen", "d": [], "t": []}], "preferred_name": "endothelial cell of venous sinus of spleen", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "CL:0001011", "l": "immature interstitial dendritic cell", "d": ["Immature interstitial dendritic cell is a interstitial dendritic cell that is CD80-low, CD86-low, and MHCII-low."], "t": []}], "preferred_name": "immature interstitial dendritic cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4524369", "l": "CD19CAR-CD28-CD3zeta-EGFRt-expressing Tcm-enriched T-lymphocytes", "d": [], "t": []}], "preferred_name": "CD19CAR-CD28-CD3zeta-EGFRt-expressing Tcm-enriched T-lymphocytes", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0682547", "l": "Eosinophilic cell", "d": [], "t": []}], "preferred_name": "Eosinophilic cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5170940", "l": "Leukocytes | Stool | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Leukocytes | Stool | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": 88.20185721311867, "identifiers": [{"i": "CL:1000353", "l": "microfold cell of epithelium of small intestine", "d": ["A M cell that is part of the epithelium of small intestine."], "t": []}, {"i": "UMLS:C2338668", "l": "Microfold cell of epithelium of small intestine", "d": [], "t": []}], "preferred_name": "microfold cell of epithelium of small intestine", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5205406", "l": "Allogeneic CD34+-enriched and CD45RA-depleted PBSCs", "d": [], "t": []}, {"i": "NCIT:C160621", "l": "Allogeneic CD34+-enriched and CD45RA-depleted PBSCs", "d": ["A preparation of donor-derived peripheral blood stem cells (PBSCs) that have been enriched with CD34-positive stem cells and have been depleted of CD45RA-positive cells, that can potentially be used for immune reconstitution purposes. CD45RA depletion results in a cellular product that contains a high amount of memory T-cells (Tm). Upon infusion of the allogeneic CD34+-enriched and CD45RA-depleted PBSCs after a hematopoietic cell transplantation (HCT), these cells provide Tm recovery and are able to prevent viral infections. The depletion of the CD45RA-positive cells reduces the risk of graft-versus-host disease (GvHD) upon infusion. CD45RA is expressed on naive T-cells (Tn), whereas Tm cells are CD45RA-negative. Tn cells have the potential to induce more severe GvHD than Tm cells."], "t": []}], "preferred_name": "Allogeneic CD34+-enriched and CD45RA-depleted PBSCs", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4033094", "l": "age-associated B cell", "d": ["A transcriptionally distinct memory B cell whose presence increases with age, during infections, and in autoimmune diseases. In humans and mice, this cell type can be identified by the expression of T-bet, CD11c, CD11b, and the lack of CD21. An age-associated B cell responds to TLR stimuli, may produce autoantibodies, and participates in antiviral responses and pathogen clearance."], "t": []}], "preferred_name": "age-associated B cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0872357", "l": "oval cell", "d": [], "t": []}], "preferred_name": "oval cell", "taxa": []}
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{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5571781", "l": "Siderocytes.Type 3", "d": [], "t": []}], "preferred_name": "Siderocytes.Type 3", "taxa": []}
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{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0002164", "l": "external pillar cell of cochlea", "d": ["A rod-shaped cell found in 3 or 4 rows that lie adjacent to and support the outer hair cells."], "t": []}, {"i": "UMLS:C1184877", "l": "External pillar cell of cochlea", "d": [], "t": []}], "preferred_name": "external pillar cell of cochlea", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0002472", "l": "MHC-II-low non-classical monocyte", "d": ["Gr1-low non-classical monocyte that has low to intermediate expression of the MHC-II complex."], "t": []}], "preferred_name": "MHC-II-low non-classical monocyte", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5833290", "l": "Nonspermatozoal cells | Semen | Fertility testing", "d": [], "t": []}], "preferred_name": "Nonspermatozoal cells | Semen | Fertility testing", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4266557", "l": "Hematopoietic progenitor cells^BPU", "d": [], "t": []}], "preferred_name": "Hematopoietic progenitor cells^BPU", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5776905", "l": "Megakaryocytes | Blood | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Megakaryocytes | Blood | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5382749", "l": "CD107a+b expressing HLA-B7 Cytomegalovirus specific CD8 cells | Blood | Cell markers", "d": [], "t": []}], "preferred_name": "CD107a+b expressing HLA-B7 Cytomegalovirus specific CD8 cells | Blood | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5177461", "l": "Plasma cells.abnormal marker pattern/Cells counted | Bone marrow | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Plasma cells.abnormal marker pattern/Cells counted | Bone marrow | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": 84.21065366064373, "identifiers": [{"i": "UMLS:C1881593", "l": "Malignant Sex Cord-Stromal Cell", "d": [], "t": []}, {"i": "NCIT:C61416", "l": "Malignant Sex Cord-Stromal Cell", "d": [], "t": []}], "preferred_name": "Malignant Sex Cord-Stromal Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 60.58119588139418, "identifiers": [{"i": "UMLS:C0221910", "l": "Squamous Epithelial Cells", "d": [], "t": []}, {"i": "NCIT:C12849", "l": "Squamous Cell", "d": [], "t": []}, {"i": "SNOMEDCT:80554009", "l": "", "d": [], "t": []}], "preferred_name": "Squamous Epithelial Cells", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:1000368", "l": "transitional myocyte of anterior division of left branch of atrioventricular bundle", "d": ["A transitional myocyte that is part of the anterior division of left branch of atrioventricular bundle."], "t": []}, {"i": "UMLS:C2324238", "l": "Transitional myocyte of anterior division of left branch of atrioventricular bundle", "d": [], "t": []}], "preferred_name": "transitional myocyte of anterior division of left branch of atrioventricular bundle", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "CL:0005003", "l": "leucoblast", "d": ["A non-terminally differentiated cell that originates from the neural crest and differentiates into a leucophore."], "t": []}], "preferred_name": "leucoblast", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5185786", "l": "ZAP70 cells | Bone marrow | Cell markers", "d": [], "t": []}], "preferred_name": "ZAP70 cells | Bone marrow | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": 53.024355208855354, "identifiers": [{"i": "UMLS:C1510719", "l": "Abnormal Endothelial Cell", "d": [], "t": []}, {"i": "NCIT:C37086", "l": "Abnormal Endothelial Cell", "d": [], "t": []}], "preferred_name": "Abnormal Endothelial Cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5426795", "l": "Alveolar macrophages | Lower respiratory specimen | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Alveolar macrophages | Lower respiratory specimen | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5978064", "l": "Colony forming unit granulocyte macrophage | Blood | Cell markers", "d": [], "t": []}], "preferred_name": "Colony forming unit granulocyte macrophage | Blood | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": 90.871710685482, "identifiers": [{"i": "UMLS:C1708919", "l": "Malignant Stellate Cell", "d": [], "t": []}, {"i": "NCIT:C53989", "l": "Malignant Stellate Cell", "d": [], "t": []}], "preferred_name": "Malignant Stellate Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0002123", "l": "B220-low CD38-positive IgG-negative class switched memory B cell", "d": ["A B220-low CD38-positive IgG-negative memory B cell is a CD38-positive IgG-negative class switched memory B cell that lacks IgG on the cell surface with the phenotype B220-low, CD38-positive, and IgG-positive."], "t": []}], "preferred_name": "B220-low CD38-positive IgG-negative class switched memory B cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5175160", "l": "Nucleated erythrocytes | Fetus | Blood | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Nucleated erythrocytes | Fetus | Blood | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5216303", "l": "Nucleated cells|NCnc|Pt|Plr fld", "d": [], "t": []}], "preferred_name": "Nucleated cells|NCnc|Pt|Plr fld", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5448026", "l": "Autologous Anti-PSMA CAR-T Cells P-PSMA-101", "d": [], "t": []}, {"i": "NCIT:C175511", "l": "Autologous Anti-PSMA CAR-T Cells P-PSMA-101", "d": ["A preparation of autologous T-cells that are enriched to be primarily stem memory T-cells (Tscm) and are transfected by electroporation with a proprietary transposon-based DNA plasmid vector (PiggyBac), encoding both a chimeric antigen receptor (CAR) based on a proprietary non-immunoglobulin scaffold molecule Centyrin (CARTyrin), which specifically recognizes the tumor-associated antigen (TAA) prostate-specific membrane antigen (PSMA), and a human-derived safety switch that can be activated by rimiducid, with potential immunostimulating and antineoplastic activities. Upon administration, autologous anti-PSMA CAR-T cells P-PSMA-101 specifically recognize and induce selective toxicity in PSMA-expressing tumor cells. Use of CARTyrin may elicit less immunotoxicity than CAR T-cells based on antibody-derived single chain variable fragments (scFv), and may allow for increased persistence and decreased exhaustion for the administered T-cells. If significant side effects occur, the safety switch mechanism can be activated by the administration of rimiducid, which results in the rapid attenuation or elimination of P-PSMA-101. PSMA is overexpressed on the surface of metastatic and hormone-refractory prostate cancer cells."], "t": []}], "preferred_name": "Autologous Anti-PSMA CAR-T Cells P-PSMA-101", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1440330", "l": "CD51+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:1372905002", "l": "", "d": [], "t": []}], "preferred_name": "CD51+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0000140", "l": "odontocyte", "d": ["Skeletogenic cell that secretes dentine matrix, is derived from odontogenic papilla. Embedded in dentine tissue, and is the transformation of a non-terminally differentiated odontoblast cell."], "t": []}], "preferred_name": "odontocyte", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5213934", "l": "Plasma cells monotypic population | Bone marrow | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Plasma cells monotypic population | Bone marrow | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": 59.875860871108024, "identifiers": [{"i": "CL:0000413", "l": "haploid cell", "d": ["A cell whose nucleus contains a single haploid genome."], "t": []}, {"i": "UMLS:C1257912", "l": "Haploid Cell", "d": [], "t": []}], "preferred_name": "haploid cell", "taxa": []}
{"type": "biolink:Cell", "ic": 92.76600187037766, "identifiers": [{"i": "NCIT:C12644", "l": "Motor Neuron", "d": ["An efferent neuron that sends impulses from the central nervous system to skeletal muscles."], "t": []}], "preferred_name": "Motor Neuron", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4072043", "l": "L5 extratelencephalic projecting glutamatergic cortical neuron (Homo sapiens)", "d": ["A transcriptomically distinct glutamatergic neuron, with a soma found in the deeper portion of L5, that has long-range axonal projections including deep subcortical targets outside of the telencephalon and, in some cases, the spinal cord. While the L5 ET neuron projections are not limited to ET targets, they are clearly differentiated from the neuron subclasses whose projections are constrained to intratelencephalic (IT) targets. L5 ET neurons are generally the largest excitatory cortical neurons, typically having a thick apical dendrite with a prominent dendritic tuft in layer 1 and displaying burst-firing physiological characteristics. The standard transcriptomic reference data for this cell type can be found on the CellxGene census under the collection: 'Transcriptomic cytoarchitecture reveals principles of human neocortex organization', dataset: 'Supercluster: Deep layer (non-IT) excitatory neurons ', Author Categories: 'CrossArea_subclass', clusters L5 ET."], "t": []}], "preferred_name": "L5 extratelencephalic projecting glutamatergic cortical neuron (Homo sapiens)", "taxa": []}
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{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1440249", "l": "CD12+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:1372828002", "l": "", "d": [], "t": []}], "preferred_name": "CD12+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C2350468", "l": "Lymphocyte-Activated Killer Cells", "d": [], "t": []}], "preferred_name": "Lymphocyte-Activated Killer Cells", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "CL:0001052", "l": "CD8-positive, CXCR3-negative, CCR6-negative, alpha-beta T cell", "d": ["A CD8-positive, alpha-beta T cell that has the phenotype CXCR3-negative, CCR6-negative."], "t": []}], "preferred_name": "CD8-positive, CXCR3-negative, CCR6-negative, alpha-beta T cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C3496530", "l": "telencephalic dopamine cells", "d": [], "t": []}], "preferred_name": "telencephalic dopamine cells", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0597407", "l": "retinal bipolar neuron", "d": [], "t": []}], "preferred_name": "retinal bipolar neuron", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4518148", "l": "Population of all spermatozoa with coiled tail in portion of fluid", "d": [], "t": []}, {"i": "SNOMEDCT:725254007", "l": "", "d": [], "t": []}], "preferred_name": "Population of all spermatozoa with coiled tail in portion of fluid", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0020022", "l": "prehypertrophic chondrocyte", "d": ["A post-proliferative chondrocyte in the prehypertrophic zone of the cartilage tissue, located between the proliferative and hypertrophic zones. This cell is characterised by increased cell volume and expression of Indian Hedgehog (Ihh), PTH1R, and Runx2/3 in both humans and mice (Hallett et al., 2021). It coordinates the PTHrP-Ihh feedback loop that regulates chondrocyte differentiation and functions as a signalling hub for communication between proliferative chondrocytes, hypertrophic chondrocytes, and periosteal osteoblasts (Hallett et al., 2021)."], "t": []}], "preferred_name": "prehypertrophic chondrocyte", "taxa": []}
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{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "UMLS:C1516398", "l": "Cerebriform-Like Lymphocyte", "d": [], "t": []}, {"i": "NCIT:C39708", "l": "Cerebriform-Like Lymphocyte", "d": [], "t": []}], "preferred_name": "Cerebriform-Like Lymphocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5206588", "l": "Autologous c-Met/PD-L1-specific CAR T-cells", "d": [], "t": []}, {"i": "NCIT:C162481", "l": "Autologous c-Met/PD-L1-specific CAR T-cells", "d": ["A preparation of autologous T-lymphocytes that have been transduced with a lentiviral vector encoding a chimeric antigen receptor (CAR) specific for human hepatocyte growth factor receptor (HGFR or c-Met) and the immunosuppressive ligand, programmed cell death-1 ligand 1 (PD-L1; cluster of differentiation 274; CD274), with potential antineoplastic activities. Upon infusion, the autologous c-Met/PD-L1-specific CAR T-cells bind to and induce selective toxicity in c-Met- and PD-L1-expressing tumor cells. cMET, a receptor tyrosine kinase that is overexpressed or mutated in many tumor cell types, plays a key role in cancer cell growth, survival, angiogenesis, invasion, and metastasis. PD-L1 is also overexpressed by many human cancer cell types and plays a key role in the downregulation of the immune system and tumor evasion from host immunity."], "t": []}], "preferred_name": "Autologous c-Met/PD-L1-specific CAR T-cells", "taxa": []}
{"type": "biolink:Cell", "ic": 72.9312568671559, "identifiers": [{"i": "CL:2000005", "l": "brain macroglial cell", "d": ["Any macroglial cell that is part of a brain."], "t": []}], "preferred_name": "brain macroglial cell", "taxa": []}
{"type": "biolink:Cell", "ic": 87.18682603146104, "identifiers": [{"i": "CL:1000546", "l": "kidney medulla collecting duct epithelial cell", "d": ["An epithelial cell that is part of a renal medulla collecting duct."], "t": []}], "preferred_name": "kidney medulla collecting duct epithelial cell", "taxa": []}
{"type": "biolink:Cell", "ic": 79.9528279018387, "identifiers": [{"i": "UMLS:C0027950", "l": "neutrophil", "d": [], "t": []}, {"i": "NCIT:C12533", "l": "Neutrophil", "d": ["Granular leukocytes having a nucleus with three to five lobes connected by slender threads of chromatin, and cytoplasm containing fine inconspicuous granules and stainable by neutral dyes."], "t": []}, {"i": "MESH:D009504", "l": "Neutrophils", "d": [], "t": []}], "preferred_name": "neutrophil", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5827061", "l": "Human Embryonic Stem Cell-derived Astrocytes", "d": [], "t": []}], "preferred_name": "Human Embryonic Stem Cell-derived Astrocytes", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1440423", "l": "Terminal deoxyribonucleotidyl transferase cells", "d": [], "t": []}], "preferred_name": "Terminal deoxyribonucleotidyl transferase cells", "taxa": []}
{"type": "biolink:Cell", "ic": 92.76600187037766, "identifiers": [{"i": "CL:1000849", "l": "kidney distal convoluted tubule epithelial cell", "d": ["Any epithelial cell of distal tubule that is part of some distal convoluted tubule."], "t": []}], "preferred_name": "kidney distal convoluted tubule epithelial cell", "taxa": []}
{"type": "biolink:Cell", "ic": 74.24062392510156, "identifiers": [{"i": "UMLS:C1711387", "l": "Neoplastic Adrenal Cortical Cell", "d": [], "t": []}, {"i": "NCIT:C48361", "l": "Neoplastic Adrenal Cortical Cell", "d": [], "t": []}], "preferred_name": "Neoplastic Adrenal Cortical Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5555853", "l": "Autologous IL-12/Multi-targeted Primed T-cells RPTR 168", "d": [], "t": []}, {"i": "NCIT:C179663", "l": "Autologous IL-12/Multi-targeted Primed T-cells RPTR 168", "d": ["A preparation of genetically modified, multi-antigen-targeted autologous T-lymphocytes, tethered with the human immunostimulatory cytokine interleukin-12 (IL-12), with potential immunostimulating and antineoplastic activities. RPTR 168 is prepared from monocyte-derived dendritic cells (moDCs) that are pulsed with five tumor-associated antigens (TAAs) to expand cytotoxic T-lymphocytes (CTLs) that are subsequently loaded with IL-12. Upon administration, the autologous IL-12/multi-targeted primed T-cells RPTR 168 specifically target tumor cells expressing the five TAAs, which lead to a specific cytotoxic T-lymphocyte (CTL)-mediated killing of these tumor cells. In addition, IL-12 expression activates the immune system by promoting the secretion of interferon-gamma (IFN-g), activating natural killer cells (NKs), and inducing CTL responses, which may further increase tumor cell death and decrease tumor cell proliferation."], "t": []}], "preferred_name": "Autologous IL-12/Multi-targeted Primed T-cells RPTR 168", "taxa": []}
{"type": "biolink:Cell", "ic": 74.78966420922332, "identifiers": [{"i": "UMLS:C1514809", "l": "Reed-Sternberg-Like Cell", "d": [], "t": []}, {"i": "NCIT:C37024", "l": "Reed-Sternberg-Like Cell", "d": [], "t": []}], "preferred_name": "Reed-Sternberg-Like Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C3831440", "l": "Autologous CD19-28z Chimeric Antigen Receptor-expressing T-lymphocytes", "d": [], "t": []}, {"i": "NCIT:C106247", "l": "Autologous CD19-28z Chimeric Antigen Receptor-expressing T-lymphocytes", "d": ["Genetically modified autologous T-lymphocytes transduced with a replication incompetent retroviral vector expressing a chimeric T cell antigen receptor (CAR) consisting of an anti-CD19 scFv (single chain variable fragment), fused to the extracellular, transmembrane and intracellular signaling domains of the T cell co-stimulatory receptor CD28 and the cytoplasmic signaling domain of the zeta chain of the TCR/CD3 complex (CD3-zeta) (CAR19-28z), with potential antineoplastic activities. Upon intravenous administration, autologous CD19-28z CAR-expressing T-lymphocytes are directed to CD19-expressing tumor cells, which induces selective toxicity in CD19-expressing tumor cells. CD19 antigen is a B-cell specific cell surface antigen expressed in all B-cell lineage malignancies. The CD28 co-stimulatory molecule signaling domain enhances activation and signaling after recognition of CD19. The inclusion of the CD28 signaling domain may increase proliferation of T-cells and antitumor activity compared to the inclusion of the CD3-zeta chain alone."], "t": []}], "preferred_name": "Autologous CD19-28z Chimeric Antigen Receptor-expressing T-lymphocytes", "taxa": []}
{"type": "biolink:Cell", "ic": 75.38868324457971, "identifiers": [{"i": "UMLS:C1881542", "l": "Malignant Cutaneous Basal Cell", "d": [], "t": []}, {"i": "NCIT:C60783", "l": "Malignant Cutaneous Basal Cell", "d": [], "t": []}], "preferred_name": "Malignant Cutaneous Basal Cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5172546", "l": "Metamyelocytes | Blood | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Metamyelocytes | Blood | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5220575", "l": "Epithelial cells.renal|Urine/Urine sed", "d": [], "t": []}], "preferred_name": "Epithelial cells.renal|Urine/Urine sed", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "CL:0000608", "l": "zygospore", "d": ["A thick walled, sexual, resting spore formed by Zygomycetes; sometimes refers to the spore and the multi-layered cell wall that encloses the spore, the zygosporangium."], "t": []}], "preferred_name": "zygospore", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1317625", "l": "Plasma cell precursor", "d": [], "t": []}, {"i": "SNOMEDCT:1382287007", "l": "", "d": [], "t": []}], "preferred_name": "Plasma cell precursor", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C6063211", "l": "CD65w+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:1372921007", "l": "", "d": [], "t": []}], "preferred_name": "CD65w+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5170946", "l": "Leukocytes | Vitreous fluid | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Leukocytes | Vitreous fluid | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1516313", "l": "Castration Cell", "d": [], "t": []}, {"i": "NCIT:C36752", "l": "Castration Cell", "d": [], "t": []}], "preferred_name": "Castration Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "CL:0002188", "l": "glomerular endothelial cell", "d": ["An endothelial cell that is part of the glomerulus of the kidney. This cell is flattened, highly fenestrated, and plays a vital role in the formation of glomerular ultrafiltrate."], "t": []}], "preferred_name": "glomerular endothelial cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5417969", "l": "AIC100", "d": [], "t": []}, {"i": "NCIT:C173378", "l": "Autologous Anti-ICAM-1-CAR-CD28-4-1BB-CD3zeta-expressing T-cells AIC100", "d": ["A preparation of autologous T-lymphocytes that have been transduced with a lentiviral vector to express a chimeric antigen receptor (CAR) containing the Inserted (I) domain variant of lymphocyte function-associated antigen-1 (LFA-1) which targets intercellular adhesion molecule-1 (ICAM-1 or CD54), and the co-stimulatory signaling domains of CD28, 4-1BB (CD137) and CD3zeta, with potential immunostimulating and antineoplastic activities. Upon administration, autologous anti-ICAM-1-CAR-CD28-4-1BB-CD3zeta-expressing T-cells AIC100 recognize and kill ICAM-1-expressing tumor cells. ICAM-1, normally expressed on leukocytes and endothelial cells, may be overexpressed in a variety of cancers. CAR T-cells AIC100 are also engineered to express somatostatin receptor subtype 2 (SSTR2), allowing the imaging of the CAR T-cells in patients."], "t": []}], "preferred_name": "AIC100", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4033161", "l": "myenteric ganglion of small intestine nNOS neuron", "d": ["An enteric neuron that has the soma located in the myenteric ganglion of the small intestine and expresses the marker neuronal nitric oxide synthase 1 (nNOS)."], "t": []}], "preferred_name": "myenteric ganglion of small intestine nNOS neuron", "taxa": []}
{"type": "biolink:Cell", "ic": 70.82453858732072, "identifiers": [{"i": "UMLS:C1513928", "l": "Neoplastic B-Lymphoblast", "d": [], "t": []}, {"i": "NCIT:C37070", "l": "Neoplastic B-Lymphoblast", "d": [], "t": []}], "preferred_name": "Neoplastic B-Lymphoblast", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0002011", "l": "Kit-positive macrophage dendritic cell progenitor", "d": ["A progenitor cell that can give rise to plasmacytoid and myeloid dendritic cells, and to monocytes and macrophages. Marker for this cell is Kit-high, CD115-positive, CD135-positive, Cx3cr1-positive, and is Il7ra-negative."], "t": []}], "preferred_name": "Kit-positive macrophage dendritic cell progenitor", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "CL:0009042", "l": "enteroendocrine cell of colon", "d": ["An enteroendocrine cell that is located in the colon."], "t": []}], "preferred_name": "enteroendocrine cell of colon", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1317119", "l": "Immature basophils", "d": [], "t": []}, {"i": "SNOMEDCT:655141010000100", "l": "", "d": [], "t": []}], "preferred_name": "Immature basophils", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5204705", "l": "Tasadenoturev-infected Allogeneic Bone Marrow-derived Mesenchymal Stem Cells", "d": [], "t": []}, {"i": "NCIT:C159798", "l": "Tasadenoturev-infected Allogeneic Bone Marrow-derived Mesenchymal Stem Cells", "d": ["A preparation of bone marrow-derived allogeneic mesenchymal stem cells (MSCs) infected with tasadenoturev (Ad5-DNX-2401), an adenovirus serotype 5 strain that is selectively replication competent in cells defective in the Rb/p16 tumor suppressor pathway, with potential antineoplastic activity. Upon infusion of the tasadenoturev-infected bone marrow-derived MSCs, these cells target and deliver the adenovirus to tumor cells. The oncolytic virus then selectively transfects and replicates in the tumor cells, eventually leading to tumor cell lysis and the release of virus particles and various tumor associated antigens (TAAs). This may induce a systemic immune response against tumor cells expressing these TAAs and further infection and killing of nearby tumor cells by the released viral particles. Ad5-DNX-2401 contains an integrin binding RGD-4C motif, allowing Coxsackievirus and adenovirus receptor-independent infection of tumor cells, which are often deficient for Coxsackievirus and adenovirus receptors (CARs). As integral components of the late G1 restriction point, the Rb gene product and p16 are negative regulators of the cell cycle and are often defective in certain cancer types."], "t": []}], "preferred_name": "Tasadenoturev-infected Allogeneic Bone Marrow-derived Mesenchymal Stem Cells", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4033123", "l": "lumbar ganglion TH/NPY neuron", "d": ["A sympathetic neuron that has the soma located in the lumbar ganglion and expresses the marker tyrosine hydroxylase (TH) and neuropeptide Y (NPY)."], "t": []}], "preferred_name": "lumbar ganglion TH/NPY neuron", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1183200", "l": "Set of adrenergic cells in area postrema and anterior reticular nucleus [C1, C2]", "d": [], "t": []}], "preferred_name": "Set of adrenergic cells in area postrema and anterior reticular nucleus [C1, C2]", "taxa": []}
{"type": "biolink:Cell", "ic": 84.21065366064373, "identifiers": [{"i": "CL:1000413", "l": "endothelial cell of artery", "d": ["A blood vessel endothelial cell that is part of an arterial endothelium."], "t": []}, {"i": "UMLS:C1180242", "l": "Endothelial cell of artery", "d": [], "t": []}], "preferred_name": "endothelial cell of artery", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5447578", "l": "Iltamiocel", "d": [], "t": []}, {"i": "NCIT:C177094", "l": "Iltamiocel", "d": [], "t": []}], "preferred_name": "Iltamiocel", "taxa": []}
{"type": "biolink:Cell", "ic": 74.50942324134168, "identifiers": [{"i": "UMLS:C1511241", "l": "Bone Marrow-Homing Plasma Cell", "d": [], "t": []}, {"i": "NCIT:C41032", "l": "Bone Marrow-Homing Plasma Cell", "d": ["A mature white blood cell, differentiated in the bone marrow, activated to preferentially migrate to the bone marrow."], "t": []}], "preferred_name": "Bone Marrow-Homing Plasma Cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0808143", "l": "Synovial Lining Cells", "d": [], "t": []}], "preferred_name": "Synovial Lining Cells", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0020043", "l": "fasciacyte", "d": ["A mesenchymal stromal cell of the deep fascia (e.g., fascia lata) that is vimentin-positive, CD68-negative, and S-100A4-positive, organized in small clusters at the interface between fibrous fascial sublayers and loose connective tissue. It is specialized for hyaluronan-rich ECM biosynthesis, as evidenced by HAS2 mRNA expression, Alcian Blue staining, and anti-HABP immunoreactivity, and functions to regulate fascial gliding and viscoelasticity."], "t": []}], "preferred_name": "fasciacyte", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5163449", "l": "Eosinophils | Urine sediment | Urinalysis", "d": [], "t": []}], "preferred_name": "Eosinophils | Urine sediment | Urinalysis", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C3656574", "l": "CD3-CD16+CD56+HLA-DR+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:1373243004", "l": "", "d": [], "t": []}], "preferred_name": "CD3-CD16+CD56+HLA-DR+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4023113", "l": "bouton vestibular afferent neuron", "d": ["A vestibular afferent neuron that makes bouton synapses to type II hair cells."], "t": []}], "preferred_name": "bouton vestibular afferent neuron", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "CL:0002612", "l": "neuron of the ventral spinal cord", "d": ["A neuron of the ventral spinal cord."], "t": []}], "preferred_name": "neuron of the ventral spinal cord", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4304495", "l": "Population of all spherocytes in portion of fluid", "d": [], "t": []}, {"i": "SNOMEDCT:719693004", "l": "", "d": [], "t": []}], "preferred_name": "Population of all spherocytes in portion of fluid", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C4764237", "l": "EDTA Blood Cell Fraction", "d": [], "t": []}, {"i": "NCIT:C158462", "l": "EDTA Blood Cell Fraction", "d": ["The blood cells that are harvested from a cell collection tube containing EDTA."], "t": []}], "preferred_name": "EDTA Blood Cell Fraction", "taxa": []}
{"type": "biolink:Cell", "ic": 81.34422831136257, "identifiers": [{"i": "CL:0008025", "l": "noradrenergic neuron", "d": ["A neuron that release noradrenaline (noriphinephrine) as a neurotransmitter."], "t": []}], "preferred_name": "noradrenergic neuron", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5220576", "l": "Epithelial cells.squamous|Urine/Urine sed", "d": [], "t": []}], "preferred_name": "Epithelial cells.squamous|Urine/Urine sed", "taxa": []}
{"type": "biolink:Cell", "ic": 90.871710685482, "identifiers": [{"i": "CL:0002387", "l": "arthroconidium", "d": ["Cylindrical spore formed by development and compartmentation of hyphae; the hyphae are often supporting blastoconidiophores."], "t": []}], "preferred_name": "arthroconidium", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0020001", "l": "V1delta gamma-delta T cell", "d": ["A mature gamma-delta T Cell with T cell receptors consisting of the Vδ1 segment paired with various V gamma chains. This cell is enriched in the gut, skin (Davey et al., 2018) and the female reproductive tract (Wu et al., 2022). It exhibits potent cytotoxic capabilities through perforin/granzyme and death receptor pathways."], "t": []}], "preferred_name": "V1delta gamma-delta T cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:1000703", "l": "kidney pelvis urothelial cell", "d": ["Any kidney epithelial cell that is part of some kidney pelvis urothelium."], "t": []}], "preferred_name": "kidney pelvis urothelial cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C4727558", "l": "Autologous TAAs-loaded Autologous Dendritic Cells AV-GBM-1", "d": [], "t": []}, {"i": "NCIT:C154285", "l": "Autologous TAAs-loaded Autologous Dendritic Cells AV-GBM-1", "d": ["A preparation of autologous dendritic cells (DCs) loaded with immunogenic tumor-associated antigens (TAAs) derived from cultured autologous glioblastoma multiforme (GBM) tumor cells, with potential immunostimulatory and antineoplastic activities. Upon administration, the autologous TAA-loaded DCs AV-GBM-1 expose the immune system to the GBM neoantigens, which results in a cytotoxic T-lymphocyte (CTL)-mediated immune response against the autologous GBM cells leading to GBM cell lysis."], "t": []}], "preferred_name": "Autologous TAAs-loaded Autologous Dendritic Cells AV-GBM-1", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5216301", "l": "Nucleated cells|NCnc|Pt|Pericard fld", "d": [], "t": []}], "preferred_name": "Nucleated cells|NCnc|Pt|Pericard fld", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5180939", "l": "Sickle cells | Blood | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Sickle cells | Blood | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0002483", "l": "hair follicle melanocyte", "d": ["A melanocyte that produces pigment within the hair follicle."], "t": []}], "preferred_name": "hair follicle melanocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 92.76600187037766, "identifiers": [{"i": "CL:0000460", "l": "glucocorticoid secreting cell", "d": ["Any secretory cell that is capable of some glucocorticoid secretion."], "t": []}], "preferred_name": "glucocorticoid secreting cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0002517", "l": "interrenal epinephrin secreting cell", "d": ["An interrenal chromaffin cell found in teleosts that contain small, homogeneous electron-lucent granules that are separated from the vesicular membrane by a visible halo."], "t": []}], "preferred_name": "interrenal epinephrin secreting cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4253013", "l": "Set of type F cells of pancreatic islet", "d": [], "t": []}], "preferred_name": "Set of type F cells of pancreatic islet", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0003041", "l": "M9-ON retinal ganglion cell", "d": ["An M9 retinal ganglion cells with synaptic terminals in S2 and is depolarized by illumination of its receptive field center."], "t": []}], "preferred_name": "M9-ON retinal ganglion cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C2981826", "l": "Allogeneic CMV/AdV-Specific Cytotoxic T Lymphocytes", "d": [], "t": []}, {"i": "NCIT:C88310", "l": "Allogeneic CMV/AdV-Specific Cytotoxic T Lymphocytes", "d": ["A population of allogeneic cytotoxic T lymphocytes (CTLs) specifically reactive to cytomegalovirus (CMV) and adenovirus (AdV) with potential antiviral activity. Allogeneic CMV/AdV-specific cytotoxic T lymphocytes are prepared by exposing donor-derived CTLs to a lethally irradiated Epstein-Barr virus-positive lymphoblastoid B cell line (EBV-LCL) that has been transduced with a clinical-grade adenoviral vector (Ad5f35CMVpp65) as a source of CMV and AdV antigens. Infusion of these CTLs into stem cell transplant recipients may prevent CMV and AdV viral disease."], "t": []}], "preferred_name": "Allogeneic CMV/AdV-Specific Cytotoxic T Lymphocytes", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5151348", "l": "Abnormal lymphocytes | Blood | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Abnormal lymphocytes | Blood | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": 74.93438803193563, "identifiers": [{"i": "CL:0020029", "l": "cuboidal epithelial cell", "d": ["An epithelial cell that has a cuboidal morphology."], "t": []}], "preferred_name": "cuboidal epithelial cell", "taxa": []}
{"type": "biolink:Cell", "ic": 89.40238429118027, "identifiers": [{"i": "UMLS:C0935440", "l": "Cuboidal cell", "d": [], "t": []}, {"i": "NCIT:C13157", "l": "Cuboidal Cell", "d": ["A cube-shaped epithelial cell. Because a cuboidal cell has a relatively large cytoplasmic volume, it can undertake more complex functions such as absorption and secretion. Most glandular secretory cells are cuboidal epithelial cells and the ducts of most exocrine glands and kidney tubules are lined by cuboidal cells."], "t": []}], "preferred_name": "Cuboidal cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0002300", "l": "type-7 epithelial cell of thymus", "d": ["A small medullary thymic epithelial cell with a spindle shape, often arranged in groups and connected to each other by large desmosomes and interdigitations. The cytoplasm is sparse, with scanty organelles and thick bundles of cytokeratin."], "t": []}], "preferred_name": "type-7 epithelial cell of thymus", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0000926", "l": "CD4-positive type I NK T cell secreting interferon-gamma", "d": ["A mature NK T cell that secretes interferon-gamma and enhances type 1 immune responses."], "t": []}], "preferred_name": "CD4-positive type I NK T cell secreting interferon-gamma", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4310134", "l": "striosomal D2 medium spiny neuron (Primate)", "d": ["A striosomal D2 medium spiny neuron of the Primates brain. These cells are located in the striatum . Reference transcriptomic data for this type can be found in the dataset/taxonomy - HMBA Basal Ganglia Consensus Taxonomy in cell set Group:STRd D2 Striosome MSN."], "t": []}], "preferred_name": "striosomal D2 medium spiny neuron (Primate)", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4042031", "l": "immune oligodendroglia", "d": ["An oligodendrocyte of the central nervous system that exhibits immune properties such as self-presentation and non-self antigen presentation to T cells, phagocytosis of debris, and cytokine and chemokine production. Immune oligodendroglia is immunoreactive during inflammation, neurodegenerative disorders, chronic stress and major depressive disorder."], "t": []}], "preferred_name": "immune oligodendroglia", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5983928", "l": "Allogeneic Anti-CD70 CAR/dnTGF-BRII-expressing Gamma Delta T-cells ADI-270", "d": [], "t": []}, {"i": "NCIT:C212213", "l": "Allogeneic Anti-CD70 CAR/dnTGF-BRII-expressing Gamma Delta T-cells ADI-270", "d": ["A preparation of allogeneic Vdelta1 gamma delta T-lymphocytes engineered to express a chimeric antigen receptor (CAR) targeting the tumor-associated antigen (TAA) human cluster of differentiation 70 (CD70) and a dominant negative (dn) form of transforming growth factor-beta (TGF-beta; TGFb) receptor II (dnTGF-BRII), with potential immunostimulating and antineoplastic activities. Upon administration, allogeneic anti-CD70 CAR/dnTGF-BRII-expressing gamma delta T-cells ADI-270 recognize and bind to CD70-expressing tumor cells. This may result in a specific cytotoxic T-lymphocyte (CTL)-mediated killing of CD70-positive tumor cells. CD70, a type II transmembrane glycoprotein and member of the tumor necrosis factor (TNF) family, is found on the surfaces of various types of cancer cells. The inclusion of dnTGF-BRII blocks the signaling of the immunosuppressive cytokine TGFb in the tumor microenvironment (TME) and makes the ADI-270 T-cells resistant to TGFb. TGFb negatively regulates T-cell proliferation and activation and plays a key role in tumor immune suppression. Gamma delta T-lymphocytes play a key role in the activation of the immune system and do not require major histocompatibility complex (MHC)-mediated antigen presentation to exert their cytotoxic effect."], "t": []}], "preferred_name": "Allogeneic Anti-CD70 CAR/dnTGF-BRII-expressing Gamma Delta T-cells ADI-270", "taxa": []}
{"type": "biolink:Cell", "ic": 83.63771255585968, "identifiers": [{"i": "UMLS:C1709169", "l": "Neoplastic Connective and Soft Tissue Epithelioid Cell", "d": [], "t": []}, {"i": "NCIT:C43307", "l": "Neoplastic Connective and Soft Tissue Epithelioid Cell", "d": [], "t": []}], "preferred_name": "Neoplastic Connective and Soft Tissue Epithelioid Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 74.37365206292206, "identifiers": [{"i": "CL:0000174", "l": "steroid hormone secreting cell", "d": ["Any secretory cell that is capable of some steroid hormone secretion."], "t": []}], "preferred_name": "steroid hormone secreting cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5174615", "l": "Neutrophils | Cerebral spinal fluid | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Neutrophils | Cerebral spinal fluid | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5170932", "l": "Leukocytes | Nose | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Leukocytes | Nose | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1955343", "l": "Other markers", "d": [], "t": []}], "preferred_name": "Other markers", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0007022", "l": "micropylar cell", "d": ["A specialized pore forming cell of the follicle, located adjacent to the animal pole of the oocyte. The micropylar cell makes the single micropyle (pore) through the chorion through which the sperm fertilizes the egg."], "t": []}], "preferred_name": "micropylar cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4510922", "l": "Blast cell positive for CD1a antigen", "d": [], "t": []}, {"i": "SNOMEDCT:725176008", "l": "", "d": [], "t": []}], "preferred_name": "Blast cell positive for CD1a antigen", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5706376", "l": "Anti-CD19/Anti-CD20/Anti-CD22 CAR-T Cells LCAR-AIO", "d": [], "t": []}, {"i": "NCIT:C187129", "l": "Anti-CD19/Anti-CD20/Anti-CD22 CAR-T Cells LCAR-AIO", "d": ["A preparation of human T-lymphocytes that have been genetically modified and transduced with a lentiviral vector expressing a chimeric antigen receptor (CAR) targeting the tumor-associated antigens (TAAs) cluster of differentiation 19 (CD19), CD20 and CD22, with potential immunostimulating and antineoplastic activities. Upon administration, the anti-CD19/anti-CD20/anti-CD22 CAR-T cells LCAR-AIO target and bind to CD19, CD20 and CD22 expressed on the surface of certain tumor cells. This induces selective toxicity in tumor cells expressing these TAAs. The TAAs are overexpressed in certain hematologic malignancies."], "t": []}], "preferred_name": "Anti-CD19/Anti-CD20/Anti-CD22 CAR-T Cells LCAR-AIO", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5787152", "l": "Anti-EGFRvIII-CAR-CD3/EGFR BiTE-transduced Autologous T-lymphocytes CARv3-TEAM-E", "d": [], "t": []}, {"i": "NCIT:C198499", "l": "Anti-EGFRvIII-CAR-CD3/EGFR BiTE-transduced Autologous T-lymphocytes CARv3-TEAM-E", "d": ["A preparation of autologous human T-lymphocytes transduced with a CARv3-TEAM-E lentiviral vector encoding for an anti-epidermal growth factor receptor (EGFR) variant III (EGFRvIII) mutant chimeric T cell receptor (chimeric antigen receptor or CAR) and a T cell engaging antibody molecule (TEAM) which comprises a bispecific T-cell engager (BiTE) against EGFR and the T-cell signaling domain CD3, with potential immunostimulatory and antineoplastic activities. Upon administration via Ommaya reservoir of the anti-EGFRvIII CAR-CD3/EGFR BiTE-transduced autologous T-lymphocytes CARv3-TEAM-E, the lymphocytes bind to the EGFRvIII antigen on tumor cell surfaces and the BiTE binds to CD3 on bystander T-cells; thereby killing EGFRvIII-expressing tumor cells through the administered CAR-T cells and wild-type (WT) EGFR-expressing tumor cells by bystander T-cells, respectively. EGFRvIII, an in-frame deletion of exons 2-7 in the EGFR gene, is overexpressed by a variety of cancer cell types and absent in normal, healthy cells; it plays a key role in tumor cell proliferation, tumor angiogenesis and radio- and chemoresistance."], "t": []}], "preferred_name": "Anti-EGFRvIII-CAR-CD3/EGFR BiTE-transduced Autologous T-lymphocytes CARv3-TEAM-E", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0000741", "l": "spinal accessory motor neuron", "d": ["A motor neuron that is located in the cervical region of the spinal cord and selectively innervates the sternocleidmastoid or trapezius muscle. Unlike other motor neurons, they extend axons dorsally along lateral margins of the spinal cord."], "t": []}], "preferred_name": "spinal accessory motor neuron", "taxa": []}
{"type": "biolink:Cell", "ic": 92.76600187037766, "identifiers": [{"i": "CL:0002532", "l": "CD16-positive myeloid dendritic cell", "d": ["A myeloid dendritic cell found in the blood that is CD16-positive."], "t": []}], "preferred_name": "CD16-positive myeloid dendritic cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5420769", "l": "Anti-CD4 CAR T-cells", "d": [], "t": []}, {"i": "NCIT:C174420", "l": "Anti-CD4 CAR T-cells", "d": ["A preparation of T-lymphocytes that have been genetically modified and transduced with a lentiviral vector expressing a chimeric antigen receptor (CAR) targeting the tumor-associated antigen (TAA) CD4 and containing, as of yet undisclosed co-stimulatory signaling domains, with potential immunostimulating and antineoplastic activities. Upon administration, anti-CD4 CAR T-cells target and bind to CD4-expressing tumor cells, thereby inducing selective toxicity in CD4-expressing tumor cells. CD4 antigen is expressed in CD4-positive T cell lymphomas."], "t": []}], "preferred_name": "Anti-CD4 CAR T-cells", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5181218", "l": "Somatic cells | Milk | Microbiology", "d": [], "t": []}], "preferred_name": "Somatic cells | Milk | Microbiology", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5446527", "l": "Autologous Anti-kappa Light Chain CAR-CD28-expressing T-lymphocytes", "d": [], "t": []}, {"i": "NCIT:C175446", "l": "Autologous Anti-kappa Light Chain CAR-CD28-expressing T-lymphocytes", "d": ["A preparation of autologous T-lymphocytes (ATL) that have been genetically modified to express a chimeric antigen receptor (CAR) directed against the kappa light chain of immunoglobulin (Ig) and linked to the costimulatory domain of CD28, with potential immunostimulating and antineoplastic activities. Upon administration, the autologous anti-kappa light chain CAR-CD28-expressing T-lymphocytes target and bind to the kappa light chain of Ig expressed on tumor cells, resulting in T-cell-mediated tumor cell lysis. In some B-cell malignancies, the expression of the Ig light chain kappa may be increased compared to the expression of Ig light chain lambda."], "t": []}], "preferred_name": "Autologous Anti-kappa Light Chain CAR-CD28-expressing T-lymphocytes", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0009013", "l": "fetal hepatobiliary progenitor cell", "d": ["A progenitor cell with hepatic and biliary lineage potential, identified in mouse and human, and anatomically restricted to the ductal plate of fetal liver."], "t": []}], "preferred_name": "fetal hepatobiliary progenitor cell", "taxa": []}
{"type": "biolink:Cell", "ic": 45.19979061838646, "identifiers": [{"i": "CL:0002242", "l": "nucleate cell", "d": ["A cell containing at least one nucleus."], "t": []}, {"i": "UMLS:C1180059", "l": "Nucleated cell", "d": [], "t": []}], "preferred_name": "nucleate cell", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "CL:0000505", "l": "substance P secreting cell", "d": ["A peptide hormone secreting cell that secretes substance P."], "t": []}], "preferred_name": "substance P secreting cell", "taxa": []}
{"type": "biolink:Cell", "ic": 62.31208739485893, "identifiers": [{"i": "CL:4023064", "l": "caudal ganglionic eminence derived cortical interneuron", "d": ["An interneuron that is derived from the caudal ganglionic eminence."], "t": []}], "preferred_name": "caudal ganglionic eminence derived cortical interneuron", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5186221", "l": "Eosinophils | Fetus | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Eosinophils | Fetus | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5873072", "l": "Ex-vivo expanded placental adherent stromal cells", "d": [], "t": []}], "preferred_name": "Ex-vivo expanded placental adherent stromal cells", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5785381", "l": "Universal Donor Expanded TGF-beta-imprinted NK Cells", "d": [], "t": []}, {"i": "NCIT:C192713", "l": "Universal Donor Expanded TGF-beta-imprinted NK Cells", "d": ["A preparation of ex vivo expanded, universal donor, transforming growth factor-beta (TGF-beta; TGF-b) imprinted natural killer (NK) cells, with potential cytolytic and antineoplastic activities. Upon administration, the universal donor expanded TGF-beta-imprinted NK cells may directly lyse cancer cells. These cells also secrete pro-inflammatory cytokines and further stimulate a systemic immune response against cancer cells. TGF-beta imprinting during NK cell activation and expansion decreases NK cell sensitivity to TGF-beta suppression and promotes NK cell cytokine hypersecretion, specifically of interferon-gamma (IFNg) and tumor necrosis factor-alpha (TNFa), and enhances NK cytotoxicity. TGF-beta is a potent immunosuppressive cytokine that inhibits the anti-tumor responses of NK cells and T-cells."], "t": []}], "preferred_name": "Universal Donor Expanded TGF-beta-imprinted NK Cells", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "CL:0000848", "l": "microvillous olfactory receptor neuron", "d": ["An olfactory receptor cell in which the apical ending of the dendrite is a knob that bears numerous microvilli."], "t": []}], "preferred_name": "microvillous olfactory receptor neuron", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1510782", "l": "Adenocarcinoma Cell with Perinuclear Clearing", "d": [], "t": []}, {"i": "NCIT:C36841", "l": "Adenocarcinoma Cell with Perinuclear Clearing", "d": [], "t": []}], "preferred_name": "Adenocarcinoma Cell with Perinuclear Clearing", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5216244", "l": "Lymphocytes.clefted|NCnc|Pt|Bld", "d": [], "t": []}], "preferred_name": "Lymphocytes.clefted|NCnc|Pt|Bld", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "UMLS:C1514738", "l": "Reactive Glandular Cell", "d": [], "t": []}, {"i": "NCIT:C36811", "l": "Reactive Glandular Cell", "d": [], "t": []}], "preferred_name": "Reactive Glandular Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4307032", "l": "Astro-NT NN_1 Kcnk10 astrocyte (Mmus)", "d": ["A astrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Agt (Mmus), Prss35 (Mmus), C4b (Mmus). It is distinguished from other Astro-NT NN_1 cells by expression of Kcnk10, C4b. These cells are located in the Medulla, Cerebellum, brain , in or close to the regions: arbor vitae . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5212 Astro-NT NN_1."], "t": []}], "preferred_name": "Astro-NT NN_1 Kcnk10 astrocyte (Mmus)", "taxa": []}
{"type": "biolink:Cell", "ic": 75.08236434612573, "identifiers": [{"i": "CL:0000464", "l": "epidermoblast", "d": ["An epidermal progenitor cell that arises from neuroectoderm and in turn gives rise to the epidermal sheath of ventral and cephalic regions."], "t": []}], "preferred_name": "epidermoblast", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1517816", "l": "Mouse Immature B-Lymphocyte", "d": [], "t": []}, {"i": "NCIT:C22573", "l": "Mouse Immature B-Lymphocyte", "d": [], "t": []}], "preferred_name": "Mouse Immature B-Lymphocyte", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1267832", "l": "Lymphocyte positive for both CD3 antigen and CD69 antigen", "d": [], "t": []}, {"i": "SNOMEDCT:117523002", "l": "", "d": [], "t": []}], "preferred_name": "Lymphocyte positive for both CD3 antigen and CD69 antigen", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0002061", "l": "T-helper 9 cell", "d": ["A T-helper cell that is characterized by secreting interleukin 9 and responding to helminth infections. This cell-type can derives from Th2 cells in the presence of TGF-beta and IL-4. Th2 cytokine production is surpressed."], "t": []}], "preferred_name": "T-helper 9 cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5170937", "l": "Leukocytes | Semen | Fertility testing", "d": [], "t": []}], "preferred_name": "Leukocytes | Semen | Fertility testing", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1514659", "l": "RL20", "d": [], "t": []}, {"i": "NCIT:C20293", "l": "RL20", "d": ["Provider: Reliance Life Sciences, Mumbai, India. No information from provider. This cell line meets the criteria for the use of human embryonic stem cells by federally funded researchers."], "t": []}], "preferred_name": "RL20", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1514732", "l": "Rat-1", "d": [], "t": []}, {"i": "NCIT:C19584", "l": "Rat-1", "d": ["Fibroblasts used as an in vitro model for cell signaling studies"], "t": []}], "preferred_name": "Rat-1", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5157433", "l": "CD3+CD25+ cells | XXX | Cell markers", "d": [], "t": []}], "preferred_name": "CD3+CD25+ cells | XXX | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": 78.05853671694304, "identifiers": [{"i": "CL:0000556", "l": "megakaryocyte", "d": ["A large hematopoietic cell (50 to 100 micron) with a lobated nucleus. Once mature, this cell undergoes multiple rounds of endomitosis and cytoplasmic restructuring to allow platelet formation and release."], "t": []}], "preferred_name": "megakaryocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 55.86172594839772, "identifiers": [{"i": "CL:0000710", "l": "neurecto-epithelial cell", "d": ["Epithelial cells derived from neural plate and neural crest."], "t": []}, {"i": "UMLS:C1182616", "l": "Neurecto-epithelial cell", "d": [], "t": []}], "preferred_name": "neurecto-epithelial cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C4329371", "l": "Autologous Monocytes", "d": [], "t": []}, {"i": "NCIT:C129877", "l": "Autologous Monocytes", "d": ["A preparation of autologous monocytes, with potential immunomodulating activity. Following isolation and administration, the autologous monocytes may differentiate into classic M1 macrophages, which are able to directly attack and kill tumor cells. The stimulated monocytes also promote natural killer (NK) cell differentiation, which further enhances tumor cell killing through NK-mediated cytotoxicity."], "t": []}], "preferred_name": "Autologous Monocytes", "taxa": []}
{"type": "biolink:Cell", "ic": 62.33364115833617, "identifiers": [{"i": "CL:0000785", "l": "mature B cell", "d": ["A B cell that is mature, having left the bone marrow. Initially, these cells are IgM-positive and IgD-positive, and they can be activated by antigen."], "t": []}], "preferred_name": "mature B cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1254876", "l": "Polychromic Normoblast", "d": [], "t": []}], "preferred_name": "Polychromic Normoblast", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1440108", "l": "Autologous erythrocytes", "d": [], "t": []}], "preferred_name": "Autologous erythrocytes", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5221013", "l": "Unidentified cells|NCnc|Pt|Synv fld", "d": [], "t": []}], "preferred_name": "Unidentified cells|NCnc|Pt|Synv fld", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0000419", "l": "seam cell", "d": ["An epithelial fate stem cell found in flatworms."], "t": []}], "preferred_name": "seam cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1511062", "l": "Basaloid cell", "d": [], "t": []}, {"i": "NCIT:C32190", "l": "Basaloid Cell", "d": ["A cell usually of the epidermis that resembles a basal cell."], "t": []}], "preferred_name": "Basaloid cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5417833", "l": "Autologous CRISPR-edited Anti-CD19 CAR T Cells XYF19", "d": [], "t": []}, {"i": "NCIT:C170914", "l": "Autologous CRISPR-edited Anti-CD19 CAR T Cells XYF19", "d": ["A preparation of autologous T-lymphocytes transduced with a lentiviral vector encoding a chimeric antigen receptor (CAR) specific for the tumor-associated antigen (TAA) CD19, and electroporated with clustered regularly interspaced short palindromic repeats (CRISPR) guide RNA to disrupt expression of endogenous hematopoietic progenitor kinase 1 (HPK1), with potential immunostimulating and antineoplastic activities. Upon introduction into the patient, the autologous CRISPR-edited anti-CD19 CAR T-cells XYF19 recognize and bind to CD19-overexpressing tumor cells. This may result in a specific cytotoxic T-lymphocyte (CTL)-mediated killing of CD19-positive tumor cells. Disrupting the expression of HPK1 may enhance immune response and autoimmunity. CD19 antigen is a B-cell specific cell surface antigen expressed in all B-cell lineage malignancies. HPK1 is a Ste20-like serine/threonine kinase that suppresses immune responses and autoimmunity."], "t": []}], "preferred_name": "Autologous CRISPR-edited Anti-CD19 CAR T Cells XYF19", "taxa": []}
{"type": "biolink:Cell", "ic": 87.18682603146104, "identifiers": [{"i": "UMLS:C1708900", "l": "Malignant Parathyroid Gland Clear Cell", "d": [], "t": []}, {"i": "NCIT:C48270", "l": "Malignant Parathyroid Gland Clear Cell", "d": [], "t": []}], "preferred_name": "Malignant Parathyroid Gland Clear Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 72.4125108737624, "identifiers": [{"i": "UMLS:C0085983", "l": "Cell Line, Tumor", "d": [], "t": []}, {"i": "NCIT:C20313", "l": "Tumor Cell Line", "d": [], "t": []}, {"i": "MESH:D045744", "l": "Cell Line, Tumor", "d": [], "t": []}], "preferred_name": "Cell Line, Tumor", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1267915", "l": "Lymphocyte positive for CD38 antigen", "d": [], "t": []}, {"i": "SNOMEDCT:116845004", "l": "", "d": [], "t": []}], "preferred_name": "Lymphocyte positive for CD38 antigen", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0333722", "l": "Tadpole cell", "d": [], "t": []}, {"i": "SNOMEDCT:112657009", "l": "", "d": [], "t": []}], "preferred_name": "Tadpole cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:2000070", "l": "optic choroid fibroblast", "d": ["Any fibroblast that is part of a optic choroid."], "t": []}], "preferred_name": "optic choroid fibroblast", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5206131", "l": "Autologous Anti-CD7 CAR/28zeta CRISPR-edited T-lymphocytes", "d": [], "t": []}, {"i": "NCIT:C161832", "l": "Autologous Anti-CD7 CAR/28zeta CRISPR-edited T-lymphocytes", "d": ["A preparation of autologous T-lymphocytes (ATL) that have been gene-edited with the clustered regularly interspaced short palindromic repeats (CRISPR)-caspase 9 (Casp9) to remove the CD7 antigen and genetically engineered to express a chimeric antigen receptor (CAR) composed of a single-chain variable fragment (scFv) directed against the CD7 antigen and linked to the co-stimulatory domains of CD28 and the zeta chain of the TCR/CD3 complex (CD3-zeta) (CD28zeta), with potential immunostimulating and antineoplastic activities. Upon administration, the autologous anti-CD7 CAR/28zeta CRISPR-edited T-lymphocytes specifically recognize and bind to CD7-expressing tumor cells, resulting in specific T-cell-mediated tumor cell lysis. CD7 is a transmembrane glycoprotein expressed by T-cells and natural killer (NK) cells and their precursors. It is expressed in the majority of lymphoblastic T-cell leukemias and lymphomas and in a subset of peripheral T-cell lymphomas. Removal of the endogenous CD7 antigen from the T-cell surface increases expansion and viability of the CAR-T cells and increases T-cell cytotoxic activity."], "t": []}], "preferred_name": "Autologous Anti-CD7 CAR/28zeta CRISPR-edited T-lymphocytes", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1254949", "l": "Nk Lymphocyte", "d": [], "t": []}], "preferred_name": "Nk Lymphocyte", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5142689", "l": "Plasma cells.polyclonal", "d": [], "t": []}], "preferred_name": "Plasma cells.polyclonal", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5853685", "l": "Allogeneic CRISPR/Cas9-mediated genetically modified CAR T cells targeting CD70 antigen", "d": [], "t": []}], "preferred_name": "Allogeneic CRISPR/Cas9-mediated genetically modified CAR T cells targeting CD70 antigen", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0002479", "l": "F4/80-positive adipose macrophage", "d": ["An adipose macrophage that does not express MHC-II but is F4/80-positive."], "t": []}], "preferred_name": "F4/80-positive adipose macrophage", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0282549", "l": "HL-60 Cells", "d": [], "t": []}, {"i": "MESH:D018922", "l": "HL-60 Cells", "d": [], "t": []}], "preferred_name": "HL-60 Cells", "taxa": []}
{"type": "biolink:Cell", "ic": 74.24062392510156, "identifiers": [{"i": "CL:4023059", "l": "committed oligodendrocyte precursor", "d": ["An oligodendrocyte precursor cell that is committed to differentiate."], "t": []}], "preferred_name": "committed oligodendrocyte precursor", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5173437", "l": "Monocytes | Pleural fluid | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Monocytes | Pleural fluid | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": 79.9528279018387, "identifiers": [{"i": "CL:0002308", "l": "epithelial cell of skin gland", "d": ["An epithelial cell of a skin gland."], "t": []}, {"i": "UMLS:C1182691", "l": "Epithelial cell of gland of skin", "d": [], "t": []}], "preferred_name": "epithelial cell of skin gland", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5175607", "l": "Other cells | Pleural fluid | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Other cells | Pleural fluid | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5205604", "l": "PRGN-3006", "d": [], "t": []}, {"i": "NCIT:C160847", "l": "Autologous Anti-CD33 CAR-mbIL15-Safety Switch T-cells PRGN-3006", "d": ["A preparation of autologous T-lymphocytes that have been genetically modified to co-express three transgenes using the Sleeping Beauty (SB) transposon system and include a chimeric antigen receptor (CAR) targeting the tumor-associated antigen (TAA) CD33, a membrane-bound IL-15 (mbIL15) and a safety/kill switch, with potential immunostimulating and antineoplastic activities. Upon introduction of the autologous anti-CD33 CAR-mbIL15-safety switch T-cells PRGN-3006 into the patient, the T-cells target and bind to CD33-expressing tumor cells, thereby inducing selective toxicity in CD33-expressing tumor cells. CD33, a myeloid differentiation antigen, is expressed on normal non-pluripotent hematopoietic stem cells and overexpressed on a variety of cancer cell types, including acute myeloid leukemia (AML). It plays a key role in tumor initiation, proliferation and progression. IL-15 is a pro-survival cytokine that is required for the maintenance of long-lived CD8+ memory T-cells and use of mbIL15 preserves T stem-cell memory (TSCM) through sustained IL-15 signaling, improves T-cell persistence and potentiates the immune response against tumor cells. The safety switch can promote selective elimination of the CAR-T cells. The SB system permits integration of the CAR, the IL-15 fusion variant and safety switch transgenes into T-cells without the need for viral vectors and accelerates the manufacturing process."], "t": []}], "preferred_name": "PRGN-3006", "taxa": []}
{"type": "biolink:Cell", "ic": 75.70995031940328, "identifiers": [{"i": "CL:0000185", "l": "myoepithelial cell", "d": ["Contractile cells resembling smooth muscle cells that are present in glands, notably the mammary gland, and aid in secretion. This cell has long weaving dendritic processes containing myofilament."], "t": []}], "preferred_name": "myoepithelial cell", "taxa": []}
{"type": "biolink:Cell", "ic": 84.83823963392128, "identifiers": [{"i": "CL:0000802", "l": "CD8-alpha alpha positive, gamma-delta intraepithelial T cell", "d": ["A gamma-delta intraepithelial T cell that has the phenotype CD8-alpha alpha-positive."], "t": []}], "preferred_name": "CD8-alpha alpha positive, gamma-delta intraepithelial T cell", "taxa": []}
{"type": "biolink:Cell", "ic": 75.2337427109536, "identifiers": [{"i": "CL:0000558", "l": "reticulocyte", "d": ["An immature erythrocyte that changes the protein composition of its plasma membrane by exosome formation and extrusion. The types of protein removed differ between species though removal of the transferrin receptor is apparent in mammals and birds."], "t": []}], "preferred_name": "reticulocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "UMLS:C0333805", "l": "Macrocytic erythrocyte", "d": [], "t": []}, {"i": "NCIT:C13112", "l": "Macrocytic Red Blood Cell", "d": ["An abnormally large red blood cell occurring mainly in anemias (as pernicious anemia), also called megalocyte.  Lack of vitamin B12 and folic acid could also cause macrocytes. (NCI)"], "t": []}, {"i": "SNOMEDCT:259681001", "l": "", "d": [], "t": []}], "preferred_name": "Macrocytic erythrocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5783836", "l": "Allogeneic Umbilical Cord Blood-derived CXCR4-enriched T-regulatory Cells CK0804", "d": [], "t": []}, {"i": "NCIT:C190649", "l": "Allogeneic Umbilical Cord Blood-derived CXCR4-enriched T-regulatory Cells CK0804", "d": ["A preparation of allogeneic T-regulatory cells (Tregs) derived from umbilical cord blood (UCB) and enriched with C-X-C chemokine receptor type 4 (CXCR4), with potential immunomodulatory activity. Upon administration, allogeneic UCB-derived CXCR4-enriched Tregs CK0804 may promote immunologic homeostasis and modulate immune responses. CXCR4 enrichment promotes the traffic of the Tregs to the bone marrow and its retainment in the bone marrow, as bone marrow expresses the CXCR4 ligand stromal cell-derived factor 1 (CXCL12)."], "t": []}], "preferred_name": "Allogeneic Umbilical Cord Blood-derived CXCR4-enriched T-regulatory Cells CK0804", "taxa": []}
{"type": "biolink:Cell", "ic": 80.61184433509295, "identifiers": [{"i": "CL:0004247", "l": "bistratified cell", "d": ["A neuron that stratifies dendrites at two and only two locations."], "t": []}], "preferred_name": "bistratified cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0000143", "l": "guidepost cell", "d": [], "t": []}], "preferred_name": "guidepost cell", "taxa": []}
{"type": "biolink:Cell", "ic": 80.96785908349635, "identifiers": [{"i": "CL:4052006", "l": "intestinal enteroendocrine progenitor", "d": ["An epithelial cell that is part of the crypt of Lieberkuhn, originating from intestinal stem cells and giving rise to enteroendocrine cells (EECs). In mouse and human, this cell can be characterized by the expression of Neurog3, and has the ability to proliferate and differentiate into multiple EEC subtypes. Its proliferative potential contributes to crypt growth, distinguishing it from fully differentiated EECs."], "t": []}], "preferred_name": "intestinal enteroendocrine progenitor", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C2331019", "l": "Set of cholinergic cells of dorsal tegmental area [Ch8]", "d": [], "t": []}], "preferred_name": "Set of cholinergic cells of dorsal tegmental area [Ch8]", "taxa": []}
{"type": "biolink:Cell", "ic": 76.40371442623734, "identifiers": [{"i": "CL:0000550", "l": "polychromatophilic erythroblast", "d": ["A nucleated, immature erythrocyte in which the nucleus occupies a relatively smaller part of the cell than in its precursor, the basophilic erythroblast. The cytoplasm is beginning to acquire hemoglobin and thus is no longer a purely basophilic, but takes on acidophilic aspects, which becomes progressively more marked as the cell matures. The chromatin of the nucleus is arranged in coarse, deeply staining clumps. This cell is CD71-positive and lacks hematopoeitic lineage markers."], "t": []}, {"i": "UMLS:C0229629", "l": "Polychromatophilic erythroblast", "d": [], "t": []}, {"i": "NCIT:C13131", "l": "Polychromatic Erythroblast", "d": [], "t": []}, {"i": "SNOMEDCT:16779009", "l": "", "d": [], "t": []}], "preferred_name": "polychromatophilic erythroblast", "taxa": []}
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{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0597694", "l": "Xenopus oocyte", "d": [], "t": []}], "preferred_name": "Xenopus oocyte", "taxa": []}
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{"type": "biolink:Cell", "ic": 68.98930312440238, "identifiers": [{"i": "UMLS:C1510730", "l": "Abnormal Mesothelial Cell", "d": [], "t": []}, {"i": "NCIT:C36829", "l": "Abnormal Mesothelial Cell", "d": [], "t": []}], "preferred_name": "Abnormal Mesothelial Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5557245", "l": "SMART101", "d": [], "t": []}, {"i": "NCIT:C181750", "l": "Allogeneic Human T Cell Progenitors SMART 101", "d": ["A preparation of allogeneic human T cell progenitor cells, that can potentially be used for immune reconstitution purposes. Upon administration, the allogeneic human T cell progenitors SMART 101 may accelerate immune reconstitution after T cell depleted allogeneic hematopoietic stem cell transplantation (HSCT) in patients with relapsed/refractory acute leukemia."], "t": []}], "preferred_name": "SMART101", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0003025", "l": "retinal ganglion cell C3", "d": ["A retinal ganglion cell C inner that has sparse dendritic density, and large dendritic field."], "t": []}], "preferred_name": "retinal ganglion cell C3", "taxa": []}
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{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "UMLS:C1516497", "l": "Chondrocyte-like Cell", "d": [], "t": []}, {"i": "NCIT:C36982", "l": "Chondrocyte-like Cell", "d": [], "t": []}], "preferred_name": "Chondrocyte-like Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 72.11981073685999, "identifiers": [{"i": "UMLS:C1711288", "l": "Primitive Round to Oval Cell", "d": [], "t": []}, {"i": "NCIT:C53980", "l": "Primitive Round to Oval Cell", "d": [], "t": []}], "preferred_name": "Primitive Round to Oval Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C4725691", "l": "Autologous Anti-CD19 CAR TCR-zeta/4-1BB-transduced T Lymphocytes BinD19", "d": [], "t": []}, {"i": "NCIT:C150378", "l": "Autologous Anti-CD19 CAR TCR-zeta/4-1BB-transduced T Lymphocytes BinD19", "d": ["Autologous T-lymphocytes that have been transduced with a lentiviral vector to express a T-cell receptor (TCR) consisting of a single chain variable fragment (scFv) of anti-CD19 coupled to the co-stimulatory molecule 4-1BB (CD137) and to the cytoplasmic portion of the zeta chain of the human T-cell receptor (CD3zeta), with potential immunostimulating and antineoplastic activities. Upon transfusion, the autologous anti-CD19 CAR TCR-zeta/4-1BB-transduced T-lymphocytes BinD19 target and bind to CD19-expressing neoplastic B-cells. This results in a cytotoxic T-lymphocyte (CTL) response against CD19-expressing tumor cells, the release of cytotoxic molecules and tumor cell lysis. CD19, cluster of differentiation 19, is a B-cell-specific cell surface antigen overexpressed in B-cell lineage tumors. Incorporation of the costimulatory signaling domains increases human T-cell function, expansion, and survival."], "t": []}], "preferred_name": "Autologous Anti-CD19 CAR TCR-zeta/4-1BB-transduced T Lymphocytes BinD19", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1275629", "l": "Keratocyte", "d": [], "t": []}, {"i": "SNOMEDCT:397052000", "l": "", "d": [], "t": []}], "preferred_name": "Keratocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 84.83823963392128, "identifiers": [{"i": "CL:0002034", "l": "long term hematopoietic stem cell", "d": ["A hematopoietic stem cell with long term self renewal capability. This cell is Kit-positive, Sca1-positive, CD150-positive, CD90-low, CD34-negative and Flt3-negative."], "t": []}], "preferred_name": "long term hematopoietic stem cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C6052764", "l": "Allogeneic TGFBR2 KO Anti-CD70 CAR-transduced NK Cells", "d": [], "t": []}, {"i": "NCIT:C219767", "l": "Allogeneic TGFBR2 KO Anti-CD70 CAR-transduced NK Cells", "d": ["A preparation of allogeneic natural killer cells (NKs) that have been engineered to express a chimeric antigen receptor (CAR) specific for the tumor-associated antigen (TAA) human cluster of differentiation 70 (CD70) and in which the gene transforming growth factor-beta receptor II (TGFbRII; TGFBR2; TGFBR-2) is deleted, with potential immunostimulating and antineoplastic activities. Upon administration, the allogeneic TGFBR2 KO anti-CD70 CAR-transduced NK cells target, bind to and induce selective cytotoxicity in CD70-expressing tumor cells. CD70, the ligand for the costimulatory receptor CD27, is overexpressed on the surfaces of various cancer cell types. As TGF-beta activation and release leads to NK cell inactivation, deletion of the TGFBR2 gene increases the potency, persistence and efficacy of the NK cells and enhances anti-tumor activity."], "t": []}], "preferred_name": "Allogeneic TGFBR2 KO Anti-CD70 CAR-transduced NK Cells", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4518171", "l": "Population of all squamous epithelial cells in portion of fluid", "d": [], "t": []}, {"i": "SNOMEDCT:726505005", "l": "", "d": [], "t": []}], "preferred_name": "Population of all squamous epithelial cells in portion of fluid", "taxa": []}
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{"type": "biolink:Cell", "ic": 76.9766555310214, "identifiers": [{"i": "UMLS:C1513023", "l": "Mature Cytotoxic T-Lymphocyte", "d": [], "t": []}, {"i": "NCIT:C38324", "l": "Mature Cytotoxic T-Lymphocyte", "d": ["A peripheral white blood cell that produces cytokines and kills infected target cells. It has a CD8 marker on its surface and has been activated by contact with MHC class I receptors and cytokines."], "t": []}], "preferred_name": "Mature Cytotoxic T-Lymphocyte", "taxa": []}
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{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5886241", "l": "CD200+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:1372862002", "l": "", "d": [], "t": []}], "preferred_name": "CD200+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5237351", "l": "Allogeneic CS1-specific Universal CAR-expressing T-lymphocytes UCARTCS1A", "d": [], "t": []}, {"i": "NCIT:C165661", "l": "Allogeneic CS1-specific Universal CAR-expressing T-lymphocytes UCARTCS1A", "d": ["A preparation of allogeneic, off-the-shelf (OTS), universal transcription activator-like effector nuclease (TALEN)-engineered T-lymphocytes that have been genetically modified to express a chimeric antigen receptor (CAR) targeting the tumor-associated antigen (TAA) human CS1 (CD2 subset 1; SLAM family member 7; SLAMF7; CD319; CRACC), with potential immunomodulating and antineoplastic activities. Upon transfusion of allogeneic CS1-specific universal CAR-expressing T-lymphocytes UCARTCS1A, these cells target and bind to cancer cells expressing CS1. This induces selective toxicity in and causes lysis of CS1-expressing tumor cells. SLAMF7 is a member of the signaling lymphocytic activation molecule (SLAM) family of transmembrane receptors that modulate the function of immune cells through immunoreceptor tyrosine-based switch motifs (ITSMs) and intracellular adaptor proteins. SLAMF7 is highly expressed on certain malignant plasma cells and is minimally expressed on healthy immune cells."], "t": []}], "preferred_name": "Allogeneic CS1-specific Universal CAR-expressing T-lymphocytes UCARTCS1A", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0002363", "l": "keratocyte", "d": ["A keratocyte is a specialized fibroblast residing in the cornea stroma that has a flattened, dendritic morphology; located between the lamellae with a large flattened nucleus, and lengthy processes which communicate with neighboring cells. This corneal layer, representing about 85-90% of corneal thickness, is built up from highly regular collagenous lamellae and extracellular matrix components. Keratocytes play the major role in keeping it transparent, healing its wounds, and synthesizing its components. This cell type secretes collagen I, V, VI, and keratan sulfate."], "t": []}, {"i": "UMLS:C0229130", "l": "Structure of corneal corpuscle", "d": [], "t": []}, {"i": "MESH:D060527", "l": "Corneal Keratocytes", "d": [], "t": []}, {"i": "SNOMEDCT:7884002", "l": "", "d": [], "t": []}], "preferred_name": "keratocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5667062", "l": "iPSC-derived Anti-BCMA CAR/CD16/IL-15RF-expressing CD38-eliminated NK Cells FT576", "d": [], "t": []}, {"i": "NCIT:C186430", "l": "iPSC-derived Anti-BCMA CAR/CD16/IL-15RF-expressing CD38-eliminated NK Cells FT576", "d": ["An allogeneic, off-the-shelf, natural killer (NK) cell product derived from a clonal master induced pluripotent stem cell (iPSC) line, and engineered and multiplex-edited to express a chimeric antigen receptor (CAR) specific for the tumor-associated antigen (TAA) B-cell maturation antigen (BCMA; tumor necrosis factor receptor superfamily member 17; TNFRSF17), a high-affinity, non-cleavable CD16 (hnCD16) Fc receptor and a recombinant fusion of IL-15 and IL-15 receptor alpha (IL-15RF), and to eliminate CD38 expression, with potential immunostimulatory and antineoplastic activities. Upon administration, iPSC-derived anti-BCMA CAR/CD16/IL-15RF-expressing CD38-eliminated NK cells FT576 recognize, bind to and induce selective cytotoxicity in BCMA-expressing tumor cells, leading to tumor cell lysis and the release of tumor neoantigens. Additionally, FT576 NK cells secrete inflammatory cytokines and chemokines, thereby enhancing T-cell activity and recruitment to the tumor site. BCMA, a receptor for both a proliferation-inducing ligand (APRIL) and B-cell activating factor (BAFF), is a member of the tumor necrosis factor receptor superfamily (TNFRSF). BCMA is found on the surfaces of plasma cells, is overexpressed on malignant plasma cells and plays a key role in plasma cell proliferation and survival. IL-15RF promotes the survival of NK cells and enhances the cytotoxic effect of the NK cells and the activated anti-tumor T-cells. When used in combination with monoclonal antibodies, the hnCD16 Fc receptor of FT576 binds to the Fc portion of tumor cell-bound monoclonal antibodies, leading to NK cell activation, cytokine secretion and enhanced antibody-dependent cellular cytotoxicity (ADCC). CD16, also known as Fc-gamma receptor III, is normally expressed on the surface of NK cells, neutrophils, monocytes and macrophages, and plays a key role in initiating ADCC. It is often downregulated in certain cancers, thereby inhibiting the anti-tumor immune response. The lack of CD38 in FT576 NK cells prevents NK cell fratricide upon co-administration with a CD38-targeting monoclonal antibody as CD38 is normally expressed on the surface of activated NK cells. This enhances ADCC mediated by CD38-targeting monoclonal antibodies."], "t": []}], "preferred_name": "iPSC-derived Anti-BCMA CAR/CD16/IL-15RF-expressing CD38-eliminated NK Cells FT576", "taxa": []}
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{"type": "biolink:Cell", "ic": 76.5892103226413, "identifiers": [{"i": "CL:1000494", "l": "nephron tubule epithelial cell", "d": ["An epithelial cell that is part of a nephron tubule."], "t": []}], "preferred_name": "nephron tubule epithelial cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C4726563", "l": "Autologous E6 T Cell Receptor Genetically-modified T Cells", "d": [], "t": []}, {"i": "NCIT:C151936", "l": "Autologous E6 T Cell Receptor Genetically-modified T Cells", "d": ["A preparation of human autologous peripheral blood lymphocytes (PBLs) that have been genetically engineered to express a T-cell receptor (TCR) that specifically targets the viral oncoprotein human papillomavirus type 16 (HPV-16) E6, with potential antineoplastic activity. Upon administration, the HPV E6 TCR genetically-modified T-cells target and bind to HPV-16 E6-expressing tumor cells, which leads to specific cytotoxic T-lymphocyte (CTL)-mediated killing of HPV-16 E6-positive tumor cells. HPV-16 E6, a cell surface glycoprotein, plays a key role in the tumorigenesis of various HPV-associated tumors and is absent from healthy human tissues."], "t": []}], "preferred_name": "Autologous E6 T Cell Receptor Genetically-modified T Cells", "taxa": []}
{"type": "biolink:Cell", "ic": 73.49439205968403, "identifiers": [{"i": "UMLS:C1516393", "l": "Centrocyte-Like Cell", "d": [], "t": []}, {"i": "NCIT:C37001", "l": "Centrocyte-Like Cell", "d": [], "t": []}], "preferred_name": "Centrocyte-Like Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 87.18682603146104, "identifiers": [{"i": "UMLS:C1515186", "l": "Gamma/Delta T-Lymphocyte", "d": [], "t": []}, {"i": "NCIT:C39585", "l": "Gamma/Delta T-Lymphocyte", "d": ["A resting, mature T cell that probably plays a primary role in suppressor/cytotoxic phenomena."], "t": []}], "preferred_name": "Gamma/Delta T-Lymphocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5670963", "l": "Umbilical Cord Blood-derived MAK Immune Cells", "d": [], "t": []}, {"i": "NCIT:C187036", "l": "Umbilical Cord Blood-derived MAK Immune Cells", "d": ["A preparation of mixed-activated killer (MAK) immune cells derived from human umbilical cord blood (UCB) cells, with potential cytotoxic activity. Hematopoietic stem cells (HSCs) are isolated followed by ex vivo differentiation and expansion. Upon administration, the UCB-derived MAK immune cells may lyse cancer cells."], "t": []}], "preferred_name": "Umbilical Cord Blood-derived MAK Immune Cells", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5555820", "l": "T-regulatory Cell-enriched Donor Cells", "d": [], "t": []}, {"i": "NCIT:C179619", "l": "T-regulatory Cell-enriched Donor Cells", "d": ["A preparation of donor-derived T-cells that have been enriched with donor T-regulatory (Treg) cells, with potential immunomodulating activity. Upon administration of the Treg cell-enriched donor cells prior to hematopoietic stem cell transplantation (HSCT), the donor cells may induce tolerance to HSCT and may reduce risk of relapse and graft-versus-host-disease (GVHD) in hematologic malignancies."], "t": []}], "preferred_name": "T-regulatory Cell-enriched Donor Cells", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5157369", "l": "CD2 cells | Body fluid | Cell markers", "d": [], "t": []}], "preferred_name": "CD2 cells | Body fluid | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1440386", "l": "Cells.euploid+Cells.aneuploid.population 2", "d": [], "t": []}], "preferred_name": "Cells.euploid+Cells.aneuploid.population 2", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0229647", "l": "Basophilic metamyelocyte", "d": [], "t": []}, {"i": "SNOMEDCT:63369000", "l": "", "d": [], "t": []}], "preferred_name": "Basophilic metamyelocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4033137", "l": "otic ganglion nNOS neuron", "d": ["A parasympathetic neuron that has the soma located in the otic ganglion and expresses the marker neuronal nitric oxide synthase 1 (nNOS)."], "t": []}], "preferred_name": "otic ganglion nNOS neuron", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5855712", "l": "Iduronicrin Genleukocel-T", "d": [], "t": []}], "preferred_name": "Iduronicrin Genleukocel-T", "taxa": []}
{"type": "biolink:Cell", "ic": 74.78966420922332, "identifiers": [{"i": "CL:0000609", "l": "vestibular hair cell", "d": ["A mechanoreceptor located in the acoustic maculae and the semicircular canals that mediates the sense of balance, movement, and head position. The vestibular hair cells are connected to accessory structures in such a way that movements of the head displace their stereocilia. This influences the membrane potential of the cells which relay information about movements via the vestibular part of the vestibulocochlear nerve to the brain stem."], "t": []}], "preferred_name": "vestibular hair cell", "taxa": []}
{"type": "biolink:Cell", "ic": 88.20185721311867, "identifiers": [{"i": "CL:0019001", "l": "tracheobronchial serous cell", "d": ["Any serous secreting cell that is part of the tracheobronchial epithelium."], "t": []}], "preferred_name": "tracheobronchial serous cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5173470", "l": "Monocytes+Macrophages | Peritoneal fluid | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Monocytes+Macrophages | Peritoneal fluid | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5216305", "l": "Plasma cell precursor|NCnc|Pt|Bld", "d": [], "t": []}], "preferred_name": "Plasma cell precursor|NCnc|Pt|Bld", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C3656573", "l": "Cells.CD3-CD8-CD57+", "d": [], "t": []}], "preferred_name": "Cells.CD3-CD8-CD57+", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5221142", "l": "Eosinophils|NCnc|Pt|Bld", "d": [], "t": []}], "preferred_name": "Eosinophils|NCnc|Pt|Bld", "taxa": []}
{"type": "biolink:Cell", "ic": 37.55033552430026, "identifiers": [{"i": "CL:0000099", "l": "interneuron", "d": ["Most generally any neuron which is not motor or sensory. Interneurons may also refer to neurons whose axons remain within a particular brain region as contrasted with projection neurons which have axons projecting to other brain regions."], "t": []}, {"i": "UMLS:C0021792", "l": "Interneurons", "d": [], "t": []}, {"i": "NCIT:C12625", "l": "Interneuron", "d": ["A type of neuron in the central nervous system that conducts impulses between other neurons."], "t": []}, {"i": "MESH:D007395", "l": "Interneurons", "d": [], "t": []}], "preferred_name": "interneuron", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0011011", "l": "intermediate mesodermal cell", "d": ["A cell derived from the mesoderm that is located between the paraxial mesoderm and the lateral plate."], "t": []}], "preferred_name": "intermediate mesodermal cell", "taxa": []}
{"type": "biolink:Cell", "ic": 81.34422831136257, "identifiers": [{"i": "CL:4023076", "l": "Martinotti neuron", "d": ["An interneuron that has Martinotti morphology. These interneurons are scattered throughout various layers of the cerebral cortex, sending their axons up to the cortical layer I where they form axonal arborization."], "t": []}], "preferred_name": "Martinotti neuron", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C2951827", "l": "Endothelial cell of endocardium of ventricle", "d": [], "t": []}], "preferred_name": "Endothelial cell of endocardium of ventricle", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1267949", "l": "Lymphocyte positive for CD57 antigen", "d": [], "t": []}, {"i": "SNOMEDCT:116855000", "l": "", "d": [], "t": []}], "preferred_name": "Lymphocyte positive for CD57 antigen", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:2000040", "l": "bladder microvascular endothelial cell", "d": ["Any microvascular endothelial cell that is part of a urinary bladder."], "t": []}], "preferred_name": "bladder microvascular endothelial cell", "taxa": []}
{"type": "biolink:Cell", "ic": 83.63771255585968, "identifiers": [{"i": "CL:4042035", "l": "molecular layer interneuron", "d": ["A type of cerebellar inhibitory GABAergic interneuron that is located in the molecular layer of the cerebellum. This cell type inhibits Purkinje cells and other molecular layer interneurons. This interneuron plays a crucial role in regulating cerebellar output through feedforward inhibition and is characterized by its fast-spiking properties."], "t": []}], "preferred_name": "molecular layer interneuron", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5380997", "l": "Cells.CD8.HLA-A1 CMV specific.CMV antigen stimulated gamma interferon producing", "d": [], "t": []}], "preferred_name": "Cells.CD8.HLA-A1 CMV specific.CMV antigen stimulated gamma interferon producing", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:1000358", "l": "microfold cell of epithelium proper of ileum", "d": ["A M cell that is part of the epithelium proper of ileum."], "t": []}, {"i": "UMLS:C2334042", "l": "Microfold cell of epithelium proper of ileum", "d": [], "t": []}], "preferred_name": "microfold cell of epithelium proper of ileum", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0229637", "l": "Neutrophilic myelocyte", "d": [], "t": []}, {"i": "SNOMEDCT:4717004", "l": "", "d": [], "t": []}], "preferred_name": "Neutrophilic myelocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 92.76600187037766, "identifiers": [{"i": "CL:4052036", "l": "tuft cell of nasal cavity", "d": ["A tuft cell that is part of the nasal cavity epithelium, located in both the respiratory and olfactory epithelia of the nose. This cell plays key roles in chemosensation, lipid mediator production, immune responses, and epithelial homeostasis."], "t": []}], "preferred_name": "tuft cell of nasal cavity", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1510684", "l": "ADA Transduced T Cell", "d": [], "t": []}, {"i": "NCIT:C28797", "l": "ADA Transduced T Cell", "d": ["T cells harvested from a patient with adenosine deaminase (ADA) deficiency and transduced with a vector containing the gene for ADA. ADA catalyzes the hydrolysis of adenosine to inosine; ADA deficiency causes a form of severe combined immunodeficiency (SCID).  Following genetic modification, the T cells are returned to the patient, where they produce functional ADA.  ADA-transduced T cells have been shown to improve immune function in individuals with ADA deficiency. (NCI04)"], "t": []}], "preferred_name": "ADA Transduced T Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "CL:0001001", "l": "immature CD8-alpha-negative CD11b-negative dendritic cell", "d": ["Immature CD8-alpha-negative CD11b-negative dendritic cell is a CD8-alpha-negative CD11b-negative dendritic cell that is CD80-low, CD86-low, and MHCII-low."], "t": []}], "preferred_name": "immature CD8-alpha-negative CD11b-negative dendritic cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C4528182", "l": "Derived Synovial Fluid Cell", "d": [], "t": []}, {"i": "NCIT:C138971", "l": "Derived Synovial Fluid Cell", "d": ["Cells derived from the fluid found in the cavities of synovial joints."], "t": []}], "preferred_name": "Derived Synovial Fluid Cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1267939", "l": "Lymphocyte positive for CD49D antigen", "d": [], "t": []}, {"i": "SNOMEDCT:117382009", "l": "", "d": [], "t": []}], "preferred_name": "Lymphocyte positive for CD49D antigen", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4033130", "l": "celiac ganglion CGRP neuron", "d": ["A sympathetic neuron that has the soma located in the celiac ganglion and expresses the marker calcitonin gene-related peptide (CGRP)."], "t": []}], "preferred_name": "celiac ganglion CGRP neuron", "taxa": []}
{"type": "biolink:Cell", "ic": 87.18682603146104, "identifiers": [{"i": "CL:4040002", "l": "enteroglial cell", "d": ["Glial cell that provides support to the enteric nervous system. It is involved in enteric neurotransmission, in maintaining the integrity of the mucosal barrier of the gut and serves as a link between the nervous and immune systems of the gut. In enteric nerve strands, glial processes ensheath multiaxonal bundles which distinguishes enteric glia from all other peripheral glia. Ultrastructurally, the most conspicuous trait of an enteroglial cell is the presence of 10 nm filaments, which criss-cross the cell body, form axial bundles in the processes and appear to firmly anchor the cells to the ganglionic surfaces. Similar to astrocytes, their main constituent is glial fibrillary acidic protein (GFAP)."], "t": []}], "preferred_name": "enteroglial cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C0242277", "l": "Proerythroblasts", "d": [], "t": []}, {"i": "NCIT:C13129", "l": "Proerythroblast", "d": ["The earliest of four stages in development of the normoblast."], "t": []}, {"i": "SNOMEDCT:16671004", "l": "", "d": [], "t": []}], "preferred_name": "Proerythroblasts", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5161703", "l": "Cytokeratin cells | Blood | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Cytokeratin cells | Blood | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5171673", "l": "Lymphocytes clefted | Blood | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Lymphocytes clefted | Blood | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": 76.9766555310214, "identifiers": [{"i": "CL:0000552", "l": "orthochromatic erythroblast", "d": ["The final stage of the nucleated, immature erythrocyte, before nuclear loss. Typically the cytoplasm is described as acidophilic, but it still shows a faint polychromatic tint. The nucleus is small and initially may still have coarse, clumped chromatin, as in its precursor, the polychromatophilic erythroblast, but ultimately it becomes pyknotic, and appears as a deeply staining, blue-black, homogeneous structureless mass. The nucleus is often eccentric and sometimes lobulated."], "t": []}], "preferred_name": "orthochromatic erythroblast", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0086574", "l": "Lymphoid Cells", "d": [], "t": []}], "preferred_name": "Lymphoid Cells", "taxa": []}
{"type": "biolink:Cell", "ic": 80.61184433509295, "identifiers": [{"i": "CL:0019002", "l": "tracheobronchial chondrocyte", "d": ["Any chondrocyte that is part of the tracheobronchial tree."], "t": []}], "preferred_name": "tracheobronchial chondrocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 83.63771255585968, "identifiers": [{"i": "CL:0000794", "l": "CD8-positive, alpha-beta cytotoxic T cell", "d": ["A CD8-positive, alpha-beta T cell that is capable of killing target cells in an antigen specific manner with the phenotype perforin-positive and granzyme B-positive."], "t": []}], "preferred_name": "CD8-positive, alpha-beta cytotoxic T cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0483192", "l": "CD5+CD2-", "d": [], "t": []}], "preferred_name": "CD5+CD2-", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5853480", "l": "Human glial progenitor cells", "d": [], "t": []}], "preferred_name": "Human glial progenitor cells", "taxa": []}
{"type": "biolink:Cell", "ic": 80.27409497666227, "identifiers": [{"i": "UMLS:C1519467", "l": "Spindle Melanocyte", "d": [], "t": []}, {"i": "NCIT:C36869", "l": "Spindle Melanocyte", "d": [], "t": []}], "preferred_name": "Spindle Melanocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4307030", "l": "Astro-NT NN_1 Nuf2 astrocyte (Mmus)", "d": ["A astrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Gfap (Mmus), Sfrp5 (Mmus), Cldn10 (Mmus), Riiad1 (Mmus). It is distinguished from other Astro-NT NN_1 cells by expression of Nuf2, Shroom3. These cells are located in the Cerebellum, brain , in or close to the regions: arbor vitae . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5210 Astro-NT NN_1."], "t": []}], "preferred_name": "Astro-NT NN_1 Nuf2 astrocyte (Mmus)", "taxa": []}
{"type": "biolink:Cell", "ic": 68.20715287354084, "identifiers": [{"i": "CL:0000816", "l": "immature B cell", "d": ["An immature B cell is a B cell that has the phenotype surface IgM-positive and surface IgD-negative, and have not undergone class immunoglobulin class switching or peripheral encounter with antigen and activation."], "t": []}], "preferred_name": "immature B cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4696696", "l": "CD19+CD27+IgD+IgM+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:1373159006", "l": "", "d": [], "t": []}], "preferred_name": "CD19+CD27+IgD+IgM+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5420765", "l": "BCMA CART Cells Secreting Mutant PD-1Fc Fusion Protein", "d": [], "t": []}, {"i": "NCIT:C174413", "l": "BCMA CART Cells Secreting Mutant PD-1Fc Fusion Protein", "d": ["A preparation of T-lymphocytes that have been genetically modified to express a chimeric antigen receptor (CAR) targeting the tumor-associated antigen (TAA) B-cell maturation antigen (BCMA; TNFRSF17) and secrete a fusion protein composed of programmed death 1 (PD-1; PDCD1; CD279; programmed cell death-1) and a human immunoglobulin Fc region, with potential immunomodulating and antineoplastic activities. Upon administration of the BCMA CART cells secreting mutant PD-1Fc fusion protein, these T-cells target and bind to tumor cells expressing BCMA and induce selective cytotoxicity in those tumor cells. The expressed PD-1-Fc fusion protein targets and binds to programmed death ligand 1 (PD-L1; cluster of differentiation 274; CD274; programmed cell death-1 ligand 1) expressed on tumor cells, thereby halting PD-1/PD-L1-mediated signaling. This may decrease T-cell exhaustion and may enhance T-cell activity against the PD-L1-expressing tumor cells. BCMA, a receptor for both a proliferation-inducing ligand (APRIL) and B-cell activating factor (BAFF), is a member of the tumor necrosis factor receptor superfamily (TNFRSF). BCMA is found on the surfaces of plasma cells, is overexpressed on malignant plasma cells and plays a key role in plasma cell proliferation and survival. PD-1, an immune checkpoint receptor expressed on T-cells, plays a key role in tumor immune evasion by binding to its ligand PD-L1 expressed on tumor cells."], "t": []}], "preferred_name": "BCMA CART Cells Secreting Mutant PD-1Fc Fusion Protein", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5417908", "l": "Anti-CD19 Antibody-T-cell Receptor-expressing T-cells ET019003", "d": [], "t": []}, {"i": "NCIT:C172202", "l": "Anti-CD19 Antibody-T-cell Receptor-expressing T-cells ET019003", "d": ["A preparation of T-lymphocytes that have been engineered by incorporating an as of yet undisclosed co-stimulatory molecule into T-cells expressing an anti-CD19 antibody T-cell receptor (AbTCR) structure (ET190L1), with potential immunostimulating and antineoplastic activities. Upon administration, anti-CD19 AbTCR-expressing T-cells ET019003 targets and binds to CD19-expressing tumor cells. This results in cytotoxic T-lymphocyte (CTL)-mediated elimination of CD19-positive tumor cells. The binding to CD19-expressing tumor cells may also activate the undisclosed costimulatory domain, leading to further T-cell proliferation. CD19 antigen is a B-cell specific cell surface antigen overexpressed in B-cell lineage malignancies. ET019003 is able to match the anticancer activity of chimeric antigen receptor (CAR) T-cells, while they are less likely to stimulate cytokine release syndrome (CRS) and less likely to cause cytokine-related toxicities."], "t": []}], "preferred_name": "Anti-CD19 Antibody-T-cell Receptor-expressing T-cells ET019003", "taxa": []}
{"type": "biolink:Cell", "ic": 84.83823963392128, "identifiers": [{"i": "UMLS:C0682545", "l": "Basophil cell", "d": [], "t": []}, {"i": "NCIT:C32198", "l": "Basophilic Cell", "d": ["A cell whose cytoplasm or granules stain readily with basic dyes."], "t": []}], "preferred_name": "Basophil cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5418069", "l": "Multi-antigen-directed Autologous T-cells NEXI-002", "d": [], "t": []}, {"i": "NCIT:C174128", "l": "Multi-antigen-directed Autologous T-cells NEXI-002", "d": ["A preparation of autologous T-cells targeting several multiple myeloma (MM)-associated antigens, with potential immunomodulating and antineoplastic activities. Peripheral blood mononuclear cells (PBMC) from the patient are collected and ex vivo exposed to nanoparticles that mimic antigen-presenting cells (APCs) loaded with multiple MM-associated antigens, including Wilms' tumor 1 (WT1), CD138 (syndecan-1; SDC1), cancer-testis antigen NY-ESO-1 and CS1 (CD319; CRACC; SLAMF7), and are further enriched and expanded ex-vivo before being re-introduced into the patient. Upon administration, the multi-antigen-directed autologous T-cells NEXI-002 are re-introduced into the patient, where they target and kill tumor cells expressing these antigens."], "t": []}], "preferred_name": "Multi-antigen-directed Autologous T-cells NEXI-002", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0443780", "l": "Rhytiocyte", "d": [], "t": []}], "preferred_name": "Rhytiocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "CL:0002524", "l": "disseminated nephrocyte", "d": ["A disseminated nephrocyte is a nephrocyte that filters hemolymph and is found at scattered locations in the fat body or other tissues."], "t": []}], "preferred_name": "disseminated nephrocyte", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4763340", "l": "Anaxonic neuron", "d": [], "t": []}], "preferred_name": "Anaxonic neuron", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C4290030", "l": "4SCAR-GD2-modified T-lymphocytes", "d": [], "t": []}, {"i": "NCIT:C128896", "l": "4SCAR-GD2-modified T-lymphocytes", "d": ["Genetically modified autologous T-lymphocytes transduced with a lentiviral vector encoding a fourth generation specific chimeric antigen receptor (4SCAR) specific for the disialoganglioside GD2 and which includes the CD3zeta chain and the signaling domains of the co-stimulatory molecules CD28, CD137, and CD27 fused with the suicide gene inducible caspase 9 (iCasp9), with potential immunomodulating and antineoplastic activities. Upon intravenous administration of 4SCAR-GD2 T-cells, these cells target the GD2 antigen on tumor cells to induce selective toxicity against GD2-expressing tumor cells. The tumor-associated antigen (TAA) GD2 is overexpressed on the surface of neuroblastoma cells and by other neuroectoderm-derived neoplasms, while it is minimally expressed on normal cells. iCasp9 consists of a human FK506 drug-binding domain with an F36V mutation (FKBP12-F36V) linked to human caspase 9. If the administered T-cells lead to unacceptable side effects, the chemical homodimerizer AP1903 can be administered; this binds to the drug binding FKBP12-F36V domain and activates caspase 9, which results in the apoptosis of the administered T-cells and enhances safety of this agent. CD28, CD137 and CD27, T-cell surface-associated co-stimulatory molecules, are required for full T-cell activation."], "t": []}], "preferred_name": "4SCAR-GD2-modified T-lymphocytes", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1979640", "l": "Blast cell positive for CD23 antigen", "d": [], "t": []}, {"i": "SNOMEDCT:724265007", "l": "", "d": [], "t": []}], "preferred_name": "Blast cell positive for CD23 antigen", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5556332", "l": "Anti-Senl-h19 CAR T Cells", "d": [], "t": []}, {"i": "NCIT:C180381", "l": "Anti-Senl-h19 CAR T Cells", "d": ["A preparation of T-lymphocytes that have been genetically modified to express a chimeric antigen receptor (CAR) targeting the human tumor-associated antigen (TAA) CD19, with potential immunostimulating and antineoplastic activities. Upon administration, anti-Senl-h19 CAR T cells target and bind to CD19-expressing tumor cells, thereby inducing selective toxicity in CD19-expressing tumor cells. CD19 antigen is a B-cell specific cell surface antigen expressed in all B-cell lineage malignancies."], "t": []}], "preferred_name": "Anti-Senl-h19 CAR T Cells", "taxa": []}
{"type": "biolink:Cell", "ic": 82.62268137420203, "identifiers": [{"i": "CL:1001434", "l": "olfactory bulb interneuron", "d": ["A neuron residing in the olfactory bulb that serve to process and refine signals arising from olfactory sensory neurons"], "t": []}], "preferred_name": "olfactory bulb interneuron", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5157399", "l": "CD227 cells | Blood | Cell markers", "d": [], "t": []}], "preferred_name": "CD227 cells | Blood | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5382943", "l": "Interferon-gamma producing HLA-B8 Cytomegalovirus specific CD8 cells | Blood | Cell markers", "d": [], "t": []}], "preferred_name": "Interferon-gamma producing HLA-B8 Cytomegalovirus specific CD8 cells | Blood | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C4055475", "l": "Alzheimer Type II Astrocyte", "d": [], "t": []}, {"i": "NCIT:C120911", "l": "Alzheimer Type II Astrocyte", "d": ["An abnormal and pathological astrocyte which appears enlarged and metabolically hyperactive. It is characterized by the presence of vesicular and basophilic nuclei. This cell type is not associated with Alzheimer's Disease."], "t": []}], "preferred_name": "Alzheimer Type II Astrocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0002593", "l": "smooth muscle cell of the internal thoracic artery", "d": ["A smooth muscle of the internal thoracic artery."], "t": []}], "preferred_name": "smooth muscle cell of the internal thoracic artery", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0000208", "l": "pH receptor cell", "d": [], "t": []}], "preferred_name": "pH receptor cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5157366", "l": "CD2 blasts | Bone marrow | Cell markers", "d": [], "t": []}], "preferred_name": "CD2 blasts | Bone marrow | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4079002", "l": "cervical dorsal root ganglion Nav1.7 neuron", "d": ["A nociceptor whose soma is located in the cervical dorsal root ganglion and that expresses the voltage-gated sodium channel Nav1.7 (encoded by SCN9A). This neuron is characterized by Nav1.7-dependent action potential initiation and amplification, which is essential for normal pain sensation in humans. Nav1.7 contributes approximately 50% of total sodium channel current in human DRG nociceptors (Chang et al. 2018, PMID:28424991). In human DRG, Nav1.7 immunoreactivity is detected in 54-57% of TrkA-positive neurons (Rostock et al. 2018, PMID:29229553). Human genetic evidence confirms Nav1.7 as necessary and sufficient for nociceptive function in these neurons."], "t": []}], "preferred_name": "cervical dorsal root ganglion Nav1.7 neuron", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0000523", "l": "mononuclear cytotrophoblast cell", "d": ["A cell from the inner layer of the trophoblast of the early mammalian embryo that gives rise to the outer surface and villi of the chorion. Mononuclear crytoblasts fuse to give rise to a multinuclear cytotrophoblast."], "t": []}, {"i": "UMLS:C2323406", "l": "Mononuclear cytotrophoblast cell", "d": [], "t": []}], "preferred_name": "mononuclear cytotrophoblast cell", "taxa": []}
{"type": "biolink:Cell", "ic": 92.76600187037766, "identifiers": [{"i": "CL:0000769", "l": "basophilic metamyelocyte", "d": ["A basophil precursor in the granulocytic series, being a cell intermediate in development between a basophilic myelocyte and a band form basophil. The nucleus becomes indented where the indentation is smaller than half the distance to the farthest nuclear margin; chromatin becomes coarse and clumped; specific granules predominate while primary granules are rare. Markers are CD11b-positive, CD15-positive, CD16-positive, CD24-positive, CD33-positive, and CD13-positive."], "t": []}], "preferred_name": "basophilic metamyelocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 78.80476858236055, "identifiers": [{"i": "CL:0000860", "l": "classical monocyte", "d": ["A monocyte that responds rapidly to microbial stimuli by secreting cytokines and antimicrobial factors and which is characterized by high expression of CCR2 in both rodents and humans, negative for the lineage markers CD3, CD19, and CD20, and of larger size than non-classical monocytes."], "t": []}], "preferred_name": "classical monocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 85.53200374075534, "identifiers": [{"i": "UMLS:C1514072", "l": "Neoplastic Lactotroph Cell", "d": [], "t": []}, {"i": "NCIT:C36918", "l": "Neoplastic Lactotroph Cell", "d": [], "t": []}], "preferred_name": "Neoplastic Lactotroph Cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5700402", "l": "Autologous Anti-BCMA Centyrin-based Chimeric Antigen Receptor-expressing Tscm", "d": [], "t": []}], "preferred_name": "Autologous Anti-BCMA Centyrin-based Chimeric Antigen Receptor-expressing Tscm", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4322738", "l": "CD57+ T lymphocyte", "d": [], "t": []}], "preferred_name": "CD57+ T lymphocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0002497", "l": "primary trophoblast giant cell", "d": ["A trophoblast giant cell derived from the mural trophectoderm."], "t": []}], "preferred_name": "primary trophoblast giant cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4307110", "l": "OEC NN_1 Gdpd4 olfactory ensheathing cell (Mmus)", "d": ["A olfactory ensheathing cell of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Apod (Mmus), Aqp1 (Mmus), Cldn5 (Mmus). It is distinguished from other OEC cells by expression of Gdpd4, Cldn5. These cells are located in the brain , in or close to the regions: olfactory nerve layer of main olfactory bulb . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5290 OEC NN_1."], "t": []}], "preferred_name": "OEC NN_1 Gdpd4 olfactory ensheathing cell (Mmus)", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C4725929", "l": "Autologous EGFR-specific CAR-T-Cells Expressing Anti-PD-1/CTLA-4 Antibodies", "d": [], "t": []}, {"i": "NCIT:C150695", "l": "Autologous EGFR-specific CAR-T-Cells Expressing Anti-PD-1/CTLA-4 Antibodies", "d": ["A preparation of autologous T-lymphocytes that have been activated and genetically modified to express immune checkpoint antibodies against the negative immunoregulatory receptors human cell surface receptor programmed cell death protein 1 (PD-1; PDCD1; CD279) and human T-cell receptor cytotoxic T-lymphocyte-associated antigen 4 (CTLA4; CTLA-4), and are transduced with a gene encoding a chimeric antigen receptor (CAR) specific for the human tumor-associated antigen (TAA) epidermal growth factor receptor (EGFR), with potential immunomodulating and antineoplastic activities. After isolation, activation, transduction, expansion in culture and reintroduction into the patient, the T-cells in the autologous EGFR specific CAR-T-cells expressing anti-PD-1/CTLA4 antibodies  specifically target and kill EGFR-expressing tumor cells. The anti-PD-1 antibody secreted from the CAR-T cells binds to PD-1 expressed on T-cells and prevents the interaction of PD-1 with its ligand programmed cell death 1 ligand 1 (PD-L1, PD-1L1; CD274) expressed on cancer cells, which prevents PD-1-mediated signaling and T-cell exhaustion. The anti-CTLA4 expressed by the CAR-T cells targets and binds to CTLA4 expressed on T-cells, and inhibits the CTLA4-mediated downregulation of T-cell activation. Both antibodies enhance T-cell activation, improve immunosuppression in the tumor microenvironment (TME) and improve the T-cell mediated immune response against and toxicity in EGFR-expressing tumor cells. Both PD-1 and CTLA-4 negatively regulate T-cell activation and proliferation, and play a key role in immunosuppression within the TME. EGFR, a receptor tyrosine kinase that is overexpressed in a variety of cancer cell types, plays a key role in tumor cell proliferation."], "t": []}], "preferred_name": "Autologous EGFR-specific CAR-T-Cells Expressing Anti-PD-1/CTLA-4 Antibodies", "taxa": []}
{"type": "biolink:Cell", "ic": 39.17176236832542, "identifiers": [{"i": "CL:0000338", "l": "neuroblast (sensu Nematoda and Protostomia)", "d": ["A neural precursor of the central nervous system."], "t": []}], "preferred_name": "neuroblast (sensu Nematoda and Protostomia)", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5154474", "l": "Basophils | Blood | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Basophils | Blood | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1267817", "l": "Lymphocyte positive for both CD3 antigen and CD16 antigen", "d": [], "t": []}, {"i": "SNOMEDCT:117519005", "l": "", "d": [], "t": []}], "preferred_name": "Lymphocyte positive for both CD3 antigen and CD16 antigen", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C2334370", "l": "Stellate cell of cerebral cortex", "d": [], "t": []}], "preferred_name": "Stellate cell of cerebral cortex", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1514221", "l": "Poorly Differentiated Adenocarcinoma Cell", "d": [], "t": []}, {"i": "NCIT:C36798", "l": "Poorly Differentiated Adenocarcinoma Cell", "d": [], "t": []}], "preferred_name": "Poorly Differentiated Adenocarcinoma Cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5939004", "l": "Tapeworm ova", "d": [], "t": []}], "preferred_name": "Tapeworm ova", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C4725932", "l": "Autologous FRa-4SCAR-expressing T-cells 4SCAR-FRa", "d": [], "t": []}, {"i": "NCIT:C150698", "l": "Autologous FRa-4SCAR-expressing T-cells 4SCAR-FRa", "d": ["A preparation of genetically modified autologous T-cells transduced with a replication incompetent, self-inactivating lentiviral vector expressing a fourth generation chimeric antigen receptor (4SCAR) consisting of an anti-folate receptor alpha (FRa; folate receptor 1; FOLR1) single chain variable fragment (scFv) that is coupled to the costimulatory signaling domains CD28, CD137, CD27 and the zeta chain of the T-cell receptor (CD3zeta; CD3z), and is fused with the suicide gene inducible caspase 9 (iCasp9), with potential immunostimulating and antineoplastic activities. Upon administration, autologous FRa-4SCAR-expressing T-cells 4SCAR-FRa are directed to and induce selective toxicity in FRa-expressing tumor cells. iCasp9 consists of a human FK506 drug-binding domain with an F36V mutation (FKBP12-F36V) linked to human caspase 9. If the administered T-cells lead to unacceptable side effects, the chemical homodimerizer AP1903 can be administered. AP1903 binds to the drug binding FKBP12-F36V domain and induces activation of caspase 9, which results in the apoptosis of the administered T-cells and enhances safety of this agent. FRa is overexpressed in various tumor cell types, and is associated with increased leukemic cell proliferation and aggressiveness. CD28, CD137 and CD27, T-cell surface-associated co-stimulatory molecules, are required for full T-cell activation and enhance both proliferation of T-cells and antitumor activity."], "t": []}], "preferred_name": "Autologous FRa-4SCAR-expressing T-cells 4SCAR-FRa", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5854381", "l": "Autologous CLTX-targeted CAR T-lymphocytes CHM 1101", "d": [], "t": []}, {"i": "NCIT:C198977", "l": "Autologous CLTX-targeted CAR T-lymphocytes CHM 1101", "d": ["A preparation of autologous T-lymphocytes genetically modified to express a chimeric antigen receptor (CAR) comprised of a CD28 co-stimulatory signaling domain fused to the zeta chain of the TCR/CD3 complex (CD3zeta) and coupled to chlorotoxin (CLTX), a 36-amino acid peptide derived from the venom of the deathstalker scorpion, with potential immunomodulating and antineoplastic activities. Upon administration of autologous CLTX-targeted CAR T-lymphocytes CHM 1101, the CAR-T cells are re-directed to specific brain tumor cells through its tumor-targeting domain CLTX. CLTX targets and binds to the membrane-bound endopeptidase matrix metalloproteinase-2 (MMP-2), thereby inducing selective toxicity in MMP-2-expressing tumor cells. MMP-2 is specifically upregulated in gliomas and related cancers, but is not normally expressed in the brain."], "t": []}], "preferred_name": "Autologous CLTX-targeted CAR T-lymphocytes CHM 1101", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0011007", "l": "paraxial cell", "d": ["A cell in the area of mesoderm in the neurulating embryo that flanks and forms simultaneously with the neural tube. The cells of this region give rise to somites."], "t": []}], "preferred_name": "paraxial cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5700397", "l": "Anti-CD19/CD28/zeta Modified CAR CD3+ T Lymphocytes JCAR015", "d": [], "t": []}], "preferred_name": "Anti-CD19/CD28/zeta Modified CAR CD3+ T Lymphocytes JCAR015", "taxa": []}
{"type": "biolink:Cell", "ic": 68.36711220989689, "identifiers": [{"i": "UMLS:C1519458", "l": "Neoplastic Spindle-Shaped Fibroblast", "d": [], "t": []}, {"i": "NCIT:C36955", "l": "Neoplastic Spindle-Shaped Fibroblast", "d": [], "t": []}], "preferred_name": "Neoplastic Spindle-Shaped Fibroblast", "taxa": []}
{"type": "biolink:Cell", "ic": 84.83823963392128, "identifiers": [{"i": "UMLS:C1710683", "l": "Wreath-Like Multinucleated Giant Cell", "d": [], "t": []}, {"i": "NCIT:C53640", "l": "Wreath-Like Multinucleated Giant Cell", "d": [], "t": []}], "preferred_name": "Wreath-Like Multinucleated Giant Cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1267898", "l": "Lymphocyte positive for both CD25 antigen and CD19 antigen", "d": [], "t": []}, {"i": "SNOMEDCT:116731001", "l": "", "d": [], "t": []}], "preferred_name": "Lymphocyte positive for both CD25 antigen and CD19 antigen", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5157574", "l": "CD45 (Lymphs) cells | Blood | Cell markers", "d": [], "t": []}], "preferred_name": "CD45 (Lymphs) cells | Blood | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1267807", "l": "SMIg lambda+ lymphocyte", "d": [], "t": []}, {"i": "SNOMEDCT:117511008", "l": "", "d": [], "t": []}], "preferred_name": "SMIg lambda+ lymphocyte", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C6064452", "l": "TdT+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:1381850005", "l": "", "d": [], "t": []}], "preferred_name": "TdT+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4310115", "l": "SN SOX6 Dopa substantia nigra dopaminergic neuron (Primate)", "d": ["A substantia nigra dopaminergic neuron of the Primates brain. These cells are located in the substantia nigra . Reference transcriptomic data for this type can be found in the dataset/taxonomy - HMBA Basal Ganglia Consensus Taxonomy in cell set Group:SN SOX6 Dopa."], "t": []}], "preferred_name": "SN SOX6 Dopa substantia nigra dopaminergic neuron (Primate)", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5157371", "l": "CD2 cells | Cerebral spinal fluid | Cell markers", "d": [], "t": []}], "preferred_name": "CD2 cells | Cerebral spinal fluid | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0444242", "l": "Amniotic cell specimen", "d": [], "t": []}, {"i": "SNOMEDCT:258563002", "l": "", "d": [], "t": []}], "preferred_name": "Amniotic cell specimen", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4030066", "l": "ureteric bud cell", "d": ["An epithelial cell that is part of a ureteric bud. A ureteric bud cell has the potential to induce metanephric mesenchymal cells to proliferate and convert to epithelia that form renal tubules via: (1) the secretion of multiple diffusible growth factors that rescue renal progenitors from apoptosis and stimulate them to proliferate and (2) contact-dependent mechanisms that induce mesenchymal-epithelial conversion."], "t": []}], "preferred_name": "ureteric bud cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C6050966", "l": "Autologous TGFbRII-4-1BB CSR-armored HPV16/52 E7-specific HLA-A*02:01-restricted TCR T-lymphocytes SCG142", "d": [], "t": []}, {"i": "NCIT:C217096", "l": "Autologous TGFbRII-4-1BB CSR-armored HPV16/52 E7-specific HLA-A*02:01-restricted TCR T-lymphocytes SCG142", "d": ["A preparation of autologous T-lymphocytes that have been genetically modified to express a T-cell receptor (TCR) specific for the human leukocyte antigen (HLA)-A*02:01-restricted human papillomavirus type 16 (HPV16) and 52 (HPV52) isoform E7 protein and armored with a transforming growth factor (TGF) beta receptor type 2 (TGFbetaRII; TGFbRII)-tumor necrosis factor receptor superfamily member 9 (TNFRSF9; 4-1BB; CD137) chimeric switch receptor (CSR), with potential immunomodulating and antineoplastic activities. Upon re-introduction into the patient, the autologous TGFbRII-4-1BB CSR-armored HPV16/52 E7-specific HLA-A*02:01-restricted TCR T-lymphocytes SCG142 targets and binds to HPV16 E7- and HPV52 E7-expressing tumor cells. This may lead to cytotoxic T-lymphocyte (CTL)-mediated elimination of tumor cells expressing the HPV16 E7 and HPV52 E7 antigen. HPV16 E7 and HPV52 E7, cell surface glycoproteins and tumor-associated antigens (TAAs), are overexpressed in various HPV-mediated cancers. The TGFbRII-4-1BB CSR targets and binds to TGFbRII, prevents TGFbRII signaling and, instead, promotes signaling through 4-1BB, which results in the stimulation of T-lymphocytes and enhanced tumor cell killing. This overcomes the immunosuppressive effects of TGFb signaling in the tumor microenvironment (TME) by converting suppressive signaling into a co-stimulatory signal."], "t": []}], "preferred_name": "Autologous TGFbRII-4-1BB CSR-armored HPV16/52 E7-specific HLA-A*02:01-restricted TCR T-lymphocytes SCG142", "taxa": []}
{"type": "biolink:Cell", "ic": 92.76600187037766, "identifiers": [{"i": "CL:0002101", "l": "CD38-positive naive B cell", "d": ["A CD38-positive naive B cell is a mature B cell that has the phenotype CD38-positive, surface IgD-positive, surface IgM-positive, and CD27-negative, and that has not yet been activated by antigen in the periphery."], "t": []}], "preferred_name": "CD38-positive naive B cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5157242", "l": "CD10+HLA-DR+ cells | Blood | Cell markers", "d": [], "t": []}], "preferred_name": "CD10+HLA-DR+ cells | Blood | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C3871181", "l": "Hyperchromic Red Blood Cell", "d": [], "t": []}, {"i": "NCIT:C206366", "l": "Hyperchromic Red Blood Cell", "d": ["An erythrocyte with a darker-than-normal red color due to increased hemoglobin concentration. It is seen with some types of anemia."], "t": []}], "preferred_name": "Hyperchromic Red Blood Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 83.63771255585968, "identifiers": [{"i": "CL:0008038", "l": "alpha motor neuron", "d": ["A large, multipolar lower motor neuron of the brainstem and spinal cord that innervates the extrafusal muscle fibers of skeletal muscle and are directly responsible for initiating their contraction. While their cell bodies are in the CNS (in the anterior gray horn of the spinal cord), they are part of the somatic nervous system - a branch of the PNS."], "t": []}, {"i": "UMLS:C2339990", "l": "Motor Neurons, Alpha", "d": [], "t": []}], "preferred_name": "alpha motor neuron", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1831990", "l": "Autologous Anti-gp100:154-162 T-Cell Receptor Gene-Engineered Peripheral Blood Lymphocytes", "d": [], "t": []}, {"i": "NCIT:C71748", "l": "Autologous Anti-gp100:154-162 T-Cell Receptor Gene-Engineered Peripheral Blood Lymphocytes", "d": ["Human autologous peripheral blood lymphocytes (PBLs) transduced with a glycoprotein 100 (gp100) epitope-determined T cell receptor (TCR) gene, with potential antineoplastic activity. PBLs are isolated from a melanoma patient and pulsed with a viral vector encoding the TCR specific for amino acid residues 154-162 of gp100 (KTWGQYWQV). After expansion ex vivo, the transduced autologous PBLs, expressing this specific TCR, are reintroduced into the patient and bind to melanoma cells expressing the gp100 protein, which may result in specific cytotoxic T-lymphocyte (CTL) killing of gp100-expressing melanoma cells. gp100 is a melanocyte lineage-specific antigen overexpressed in melanomas."], "t": []}], "preferred_name": "Autologous Anti-gp100:154-162 T-Cell Receptor Gene-Engineered Peripheral Blood Lymphocytes", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5171871", "l": "Macrophages | Urine sediment | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Macrophages | Urine sediment | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4518150", "l": "Population of all spermatozoa with bent midpiece in portion of fluid", "d": [], "t": []}, {"i": "SNOMEDCT:725239001", "l": "", "d": [], "t": []}], "preferred_name": "Population of all spermatozoa with bent midpiece in portion of fluid", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4518176", "l": "Population of all promyelocytes in portion of fluid", "d": [], "t": []}, {"i": "SNOMEDCT:726509004", "l": "", "d": [], "t": []}], "preferred_name": "Population of all promyelocytes in portion of fluid", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5216203", "l": "Eosinophils|NCnc|Pt|Periton fld", "d": [], "t": []}], "preferred_name": "Eosinophils|NCnc|Pt|Periton fld", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5555023", "l": "Allogeneic Anti-CD20 CAR-engineered Gamma Delta T Cells ADI-001", "d": [], "t": []}], "preferred_name": "Allogeneic Anti-CD20 CAR-engineered Gamma Delta T Cells ADI-001", "taxa": []}
{"type": "biolink:Cell", "ic": 92.76600187037766, "identifiers": [{"i": "UMLS:C1515019", "l": "Subependymal Cell", "d": [], "t": []}, {"i": "NCIT:C41452", "l": "Subependymal Cell", "d": ["A neuroepithelial cell that is situated just beneath the ependyma, which is the lining membrane of the ventricles of the brain and of the central canal of the spinal cord."], "t": []}], "preferred_name": "Subependymal Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 75.876659701315, "identifiers": [{"i": "CL:0001082", "l": "immature innate lymphoid cell", "d": ["An innate lyphoid cell with an immature phenotype."], "t": []}], "preferred_name": "immature innate lymphoid cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5706393", "l": "Allogeneic iPSC-derived Anti-CD19-CAR/IL-15-expressing NK Cells CNTY-101", "d": [], "t": []}, {"i": "NCIT:C187301", "l": "Allogeneic iPSC-derived Anti-CD19-CAR/IL-15-expressing NK Cells CNTY-101", "d": ["A preparation of allogeneic natural killer (NK) cells derived from a clonal master induced pluripotent stem cell (iPSC) line, and engineered to express a chimeric antigen receptor (CAR) consisting of an anti-CD19 single chain variable fragment (scFv) derived from the anti-CD19 monoclonal antibody FMC63 and coupled to the CD28 and zeta chain of the TCR/CD3 complex (CD3-zeta) costimulatory signaling domains, and interleukin 15 (IL-15), with potential immunostimulatory and antineoplastic activities. Upon administration, allogeneic iPSC-derived anti-CD19-CAR/IL-15-expressing NK cells CNTY-101 recognize, bind to and induce selective cytotoxicity in CD19-expressing tumor cells. IL-15 is a pro-survival cytokine that promotes T-cell persistence and potentiates the immune response against tumor cells. The human tumor associated antigen (TAA) CD19 is a B-cell specific cell surface antigen expressed in all B-cell lineage malignancies. CNTY-101 is also engineered with a safety switch composed of a shorter version of the extracellular domain of human epidermal growth factor receptor (EGFR). This allows the elimination of CNTY-101 upon the administration of anti-EGFR antibodies such as cetuximab. In addition, CNTY-101 is gene-edited to prevent its elimination by the patient's NK cells, CD4 and CD8 T-cells."], "t": []}], "preferred_name": "Allogeneic iPSC-derived Anti-CD19-CAR/IL-15-expressing NK Cells CNTY-101", "taxa": []}
{"type": "biolink:Cell", "ic": 88.20185721311867, "identifiers": [{"i": "UMLS:C1707937", "l": "Epithelial Stem Cell", "d": [], "t": []}, {"i": "NCIT:C43422", "l": "Epithelial Stem Cell", "d": [], "t": []}], "preferred_name": "Epithelial Stem Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 90.871710685482, "identifiers": [{"i": "UMLS:C1708891", "l": "Malignant Neuroectodermal Large Cell", "d": [], "t": []}, {"i": "NCIT:C54043", "l": "Malignant Neuroectodermal Large Cell", "d": [], "t": []}], "preferred_name": "Malignant Neuroectodermal Large Cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1267895", "l": "Lymphocyte positive for CD23 antigen", "d": [], "t": []}, {"i": "SNOMEDCT:117568005", "l": "", "d": [], "t": []}], "preferred_name": "Lymphocyte positive for CD23 antigen", "taxa": []}
{"type": "biolink:Cell", "ic": 76.9766555310214, "identifiers": [{"i": "CL:0002178", "l": "epithelial cell of stomach", "d": ["An epithelial cell found in the lining of the stomach."], "t": []}, {"i": "UMLS:C1179470", "l": "Epithelial cell of stomach", "d": [], "t": []}], "preferred_name": "epithelial cell of stomach", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0882768", "l": "CD1+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:725316009", "l": "", "d": [], "t": []}], "preferred_name": "CD1+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0545591", "l": "Blood, other cells", "d": [], "t": []}], "preferred_name": "Blood, other cells", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0009060", "l": "marginal zone B cell of lymph node", "d": ["A mature B cell located in the marginal zone of the lymph node."], "t": []}], "preferred_name": "marginal zone B cell of lymph node", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5700403", "l": "Allogeneic EBV-specific CTLs ATA129", "d": [], "t": []}], "preferred_name": "Allogeneic EBV-specific CTLs ATA129", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4033007", "l": "brush cell of epithelium of lobar bronchus", "d": ["A(n) brush cell that is part of a(n) epithelium of lobar bronchus."], "t": []}], "preferred_name": "brush cell of epithelium of lobar bronchus", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5690738", "l": "Bronchus-Associated Lymphoid Tissue M Cells", "d": [], "t": []}], "preferred_name": "Bronchus-Associated Lymphoid Tissue M Cells", "taxa": []}
{"type": "biolink:Cell", "ic": 89.40238429118027, "identifiers": [{"i": "CL:0000612", "l": "eosinophilic myelocyte", "d": ["A eosinophil precursor in the granulocytic series, being a cell intermediate in development between a promyelocyte and a metamyelocyte;in this stage, production of primary granules is complete and eosinophil-specific granules has started. No nucleolus is present. These cells are integrin alpha-M-positive, CD13-positive, CD15-positive, CD16-negative, CD24-positive, and CD33-positive."], "t": []}], "preferred_name": "eosinophilic myelocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 92.76600187037766, "identifiers": [{"i": "CL:0001021", "l": "CD34-positive, CD38-positive common lymphoid progenitor", "d": ["A common lymphoid progenitor that is CD10-positive, CD45RA-positive, CD34-positive and CD38-positive."], "t": []}], "preferred_name": "CD34-positive, CD38-positive common lymphoid progenitor", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0009011", "l": "transit amplifying cell of colon", "d": ["A rapidly proliferating population of cells that differentiate from stem cells of the intestinal crypt of the colon. Stem cells located in the crypts of Lieberkühn give rise to proliferating progenitor or transit amplifying cells that differentiate into the four major epithelial cell types. These include columnar absorptive cells or enterocytes, mucous secreting goblet cells, enteroendocrine cells and paneth cells."], "t": []}], "preferred_name": "transit amplifying cell of colon", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0000481", "l": "cholecystokin stimulating hormone secreting cell", "d": ["A peptide hormone secreting cell that secretes cholecystokin stimulating hormone."], "t": []}], "preferred_name": "cholecystokin stimulating hormone secreting cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1267891", "l": "Lymphocyte positive for CD21 antigen", "d": [], "t": []}, {"i": "SNOMEDCT:116843006", "l": "", "d": [], "t": []}], "preferred_name": "Lymphocyte positive for CD21 antigen", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5216263", "l": "Malignant cells|NCnc|Pt|Plr fld", "d": [], "t": []}], "preferred_name": "Malignant cells|NCnc|Pt|Plr fld", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0229641", "l": "Eosinophilic promyelocyte", "d": [], "t": []}, {"i": "SNOMEDCT:4029003", "l": "", "d": [], "t": []}], "preferred_name": "Eosinophilic promyelocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0001076", "l": "NKp46-positive innate lymphoid cell, human", "d": ["An innate lymphoid cell in the human with the phenotype NKp46-positive that is a precusor for NK cells and ILC3 cells."], "t": []}], "preferred_name": "NKp46-positive innate lymphoid cell, human", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0002403", "l": "mature Vgamma2-positive fetal thymocyte", "d": ["A thymocyte that has a T cell receptor consisting of a gamma chain containing Vgamma2 segment, and a delta chain. This cell type is CD4-negative, CD8-negative and CD24-negative. This cell-type is found in the fetal thymus."], "t": []}], "preferred_name": "mature Vgamma2-positive fetal thymocyte", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5163538", "l": "Epithelial cells | Blood | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Epithelial cells | Blood | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": 53.040126878342704, "identifiers": [{"i": "UMLS:C1513956", "l": "Neoplastic Endothelial Cell", "d": [], "t": []}, {"i": "NCIT:C37088", "l": "Neoplastic Endothelial Cell", "d": [], "t": []}], "preferred_name": "Neoplastic Endothelial Cell", "taxa": []}
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{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4740202", "l": "CD14-FLAER- cell", "d": [], "t": []}, {"i": "SNOMEDCT:1381845004", "l": "", "d": [], "t": []}], "preferred_name": "CD14-FLAER- cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1979671", "l": "CD3-CD16+CD56+CD244+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:1373218005", "l": "", "d": [], "t": []}], "preferred_name": "CD3-CD16+CD56+CD244+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": 87.18682603146104, "identifiers": [{"i": "UMLS:C1879787", "l": "Basal Cell of the Squamous Epithelium", "d": [], "t": []}, {"i": "NCIT:C61604", "l": "Basal Cell of the Squamous Epithelium", "d": ["A basal cell located in the squamous epithelium."], "t": []}], "preferred_name": "Basal Cell of the Squamous Epithelium", "taxa": []}
{"type": "biolink:Cell", "ic": 72.31349143091559, "identifiers": [{"i": "CL:1000510", "l": "kidney glomerular epithelial cell", "d": ["Any kidney epithelial cell that is part of some glomerular epithelium."], "t": []}], "preferred_name": "kidney glomerular epithelial cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5670695", "l": "Anti-5T4 CAR-NK Cells", "d": [], "t": []}, {"i": "NCIT:C186665", "l": "Anti-5T4 CAR-NK Cells", "d": ["A preparation of allogeneic natural killer cells (NKs) expressing a chimeric antigen receptor (CAR) specific for the tumor-associated antigen (TAA) oncofetal trophoblast glycoprotein (5T4; TPBG; Wnt-activated inhibitory factor 1 or WAIF1), with potential immunomodulating and antineoplastic activities. Upon transfusion, the anti-5T4 CAR-NK cells recognize, bind to and induce selective cytotoxicity in 5T4-expressing tumor cells. 5T4, a transmembrane glycoprotein, is overexpressed by a variety of cancer cell types; its expression is correlated with increased invasiveness."], "t": []}], "preferred_name": "Anti-5T4 CAR-NK Cells", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:1000331", "l": "serous cell of epithelium of bronchus", "d": ["A serous secreting cell that is part of the epithelium of bronchus."], "t": []}, {"i": "UMLS:C2335622", "l": "Serous cell of epithelium of bronchus", "d": [], "t": []}], "preferred_name": "serous cell of epithelium of bronchus", "taxa": []}
{"type": "biolink:Cell", "ic": 90.871710685482, "identifiers": [{"i": "UMLS:C1511184", "l": "Bizarre Cell with Evidence of Skeletal Muscle Differentiation", "d": [], "t": []}, {"i": "NCIT:C36953", "l": "Bizarre Cell with Evidence of Skeletal Muscle Differentiation", "d": [], "t": []}], "preferred_name": "Bizarre Cell with Evidence of Skeletal Muscle Differentiation", "taxa": []}
{"type": "biolink:Cell", "ic": 92.76600187037766, "identifiers": [{"i": "CL:0009014", "l": "Peyer's patch lymphocyte", "d": ["A lymphocyte that is part of a Peyer's patch. These cells have a major role in driving the immune response to antigens sampled from the intestinal lumen, and in regulating the formation of follicle-associated epithelium and M cells in Peyer's patches by converting intestitial enterocytes into M cells."], "t": []}], "preferred_name": "Peyer's patch lymphocyte", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5157917", "l": "Cell type | XXX | Cell markers", "d": [], "t": []}], "preferred_name": "Cell type | XXX | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4307091", "l": "OPC NN_2 oligodendrocyte precursor cell (Mmus)", "d": ["A oligodendrocyte precursor cell of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Pdgfra (Mmus), Cenpf (Mmus), Cenpa (Mmus). It is distinguished from other OPC NN cells by expression of Cenpa. These cells are located in the Isocortex, brain . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5271 OPC NN_2."], "t": []}], "preferred_name": "OPC NN_2 oligodendrocyte precursor cell (Mmus)", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4524846", "l": "Vadacabtagene leraleucel", "d": [], "t": []}], "preferred_name": "Vadacabtagene leraleucel", "taxa": []}
{"type": "biolink:Cell", "ic": 75.70995031940328, "identifiers": [{"i": "UMLS:C1513947", "l": "Neoplastic Cytotrophoblastic Cell", "d": [], "t": []}, {"i": "NCIT:C37140", "l": "Neoplastic Cytotrophoblastic Cell", "d": [], "t": []}], "preferred_name": "Neoplastic Cytotrophoblastic Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5787292", "l": "AB-201", "d": [], "t": []}, {"i": "NCIT:C212933", "l": "Allogeneic Anti-HER2 CAR-NK Cells AB-201", "d": ["A preparation of allogeneic, off-the-shelf (OTS), natural killer (NK) cells derived from cord blood (CB), ex vivo expanded and genetically modified to express a chimeric antigen receptor (CAR) specific for the tumor-associated antigen (TAA) human epidermal growth factor receptor 2 (HER2; ErbB2; HER-2), with potential immunomodulating and antineoplastic activities. Upon administration, allogeneic anti-HER2 CAR-NK cells AB-201 recognize, bind to and induce selective cytotoxicity in HER2-expressing tumor cells. HER2 is overexpressed in a variety of cancer cell types and is associated with increased tumor cell proliferation."], "t": []}, {"i": "NCIT:C69129", "l": "Anpocogin", "d": ["An 85-amino acid recombinant peptide derived from protein c2 of the hemophagocytic hookworm Ancylostoma caninum (a common canine parasite) with anticoagulant activity. Anpocogin binds to circulating activated factor X (FXa) or zymogen factor X (FX) to form a binary complex which subsequently binds to and inhibits membrane-bound activated factor VII/tissue factor complex (FVIIa/TF). When administered prophylactically, this agent may reduce the incidence of deep venous thrombosis without hemostatic compromise. Because rNAPc2 inhibits the formation of the FVIIa/TF protease complex, which may play a role in the cellular signaling of both metastatic and angiogenic processes, it may impede tumor progression."], "t": []}], "preferred_name": "AB-201", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5856870", "l": "CD371-specific/YSNVz/IL-18 CAR T Cells", "d": [], "t": []}, {"i": "NCIT:C201527", "l": "CD371-specific/YSNVz/IL-18 CAR T Cells", "d": ["A preparation of T-lymphocytes engineered to express a chimeric antigen receptor (CAR) specific for the tumor-associated antigen (TAA) C-type lectin domain family 12 member A (CLEC12A, CCL1, CD371), and expressing the pro-inflammatory cytokine interleukin 18 (IL-18), with potential antineoplastic activity. Upon intravenous administration, CD371-specific/YSNVz/IL-18 CAR T cells target, bind to, and induce selective toxicity in CD371-expressing tumor cells. IL-18 promotes T-cell persistence and potentiates the immune response against tumor cells. CD371 is expressed on the surface of acute myeloid leukemia (AML) cells and leukemic stem cells, but it is not expressed on normal hematopoietic stem cells (HSCs)."], "t": []}], "preferred_name": "CD371-specific/YSNVz/IL-18 CAR T Cells", "taxa": []}
{"type": "biolink:Cell", "ic": 59.83141974270748, "identifiers": [{"i": "CL:0000030", "l": "glioblast", "d": ["A non-terminally differentiated cell that develops form the neuroectoderm. Glioblast has the potential to differentiate into various types of glial cells, including astrocytes and oligodendrocytes."], "t": []}], "preferred_name": "glioblast", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5173497", "l": "Mononuclear cells | Pericardial fluid | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Mononuclear cells | Pericardial fluid | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": 90.871710685482, "identifiers": [{"i": "UMLS:C1882053", "l": "Neoplastic Ghost Cell", "d": [], "t": []}, {"i": "NCIT:C62111", "l": "Neoplastic Ghost Cell", "d": [], "t": []}], "preferred_name": "Neoplastic Ghost Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 84.83823963392128, "identifiers": [{"i": "UMLS:C1519986", "l": "Villous Lymphocyte", "d": [], "t": []}, {"i": "NCIT:C38727", "l": "Villous Lymphocyte", "d": [], "t": []}], "preferred_name": "Villous Lymphocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 48.13494398147835, "identifiers": [{"i": "UMLS:C1513983", "l": "Neoplastic Hematopoietic and Lymphoid Cell", "d": [], "t": []}, {"i": "NCIT:C37060", "l": "Neoplastic Hematopoietic and Lymphoid Cell", "d": [], "t": []}], "preferred_name": "Neoplastic Hematopoietic and Lymphoid Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4033052", "l": "ON parasol ganglion cell", "d": ["A parasol ganglion cell that depolarizes in response to increased light intensity in the center of its receptive field. The majority of input that this cell receives comes from DB4 bipolar cells."], "t": []}], "preferred_name": "ON parasol ganglion cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5417953", "l": "Engineered Red Blood Cells Co-expressing 4-1BBL and IL-15TP RTX-240", "d": [], "t": []}], "preferred_name": "Engineered Red Blood Cells Co-expressing 4-1BBL and IL-15TP RTX-240", "taxa": []}
{"type": "biolink:Cell", "ic": 85.53200374075534, "identifiers": [{"i": "CL:0000921", "l": "type I NK T cell", "d": ["An alpha-beta T cell expressing NK cell markers that is CD1d restricted and expresses specific V-alpha chains. NK T cells of this type recognize the glycolipid alpha-galactosylceramide in the context of CD1d."], "t": []}], "preferred_name": "type I NK T cell", "taxa": []}
{"type": "biolink:Cell", "ic": 73.98236851641934, "identifiers": [{"i": "CL:0000815", "l": "regulatory T cell", "d": ["A T cell which regulates overall immune responses as well as the responses of other T cell subsets through direct cell-cell contact and cytokine release."], "t": []}], "preferred_name": "regulatory T cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4038490", "l": "Cells.diploid.S phase", "d": [], "t": []}], "preferred_name": "Cells.diploid.S phase", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0427533", "l": "Hypogranular white blood cell", "d": [], "t": []}, {"i": "SNOMEDCT:250292003", "l": "", "d": [], "t": []}], "preferred_name": "Hypogranular white blood cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0001017", "l": "mature CD1a-positive Langerhans cell", "d": ["Mature CD1a-positive Langerhans cell is a CD1a-positive Langerhans cell that is CD80-high, CD86-high, MHCII-high and is CD83-positive."], "t": []}], "preferred_name": "mature CD1a-positive Langerhans cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4030021", "l": "kidney connecting tubule beta-intercalated cell", "d": ["A renal beta-intercalated cell that is part of the renal connecting tubule."], "t": []}], "preferred_name": "kidney connecting tubule beta-intercalated cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5827045", "l": "Autologous adipose derived mesenchymal stromal cells", "d": [], "t": []}], "preferred_name": "Autologous adipose derived mesenchymal stromal cells", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5216225", "l": "Leukocytes other|NCnc|Pt|CSF", "d": [], "t": []}], "preferred_name": "Leukocytes other|NCnc|Pt|CSF", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5964752", "l": "Autologous Anti-BCMA CAR-T Cells HBI0101", "d": [], "t": []}], "preferred_name": "Autologous Anti-BCMA CAR-T Cells HBI0101", "taxa": []}
{"type": "biolink:Cell", "ic": 55.67847469795479, "identifiers": [{"i": "CL:0000586", "l": "germ cell", "d": ["The reproductive cell in multicellular organisms."], "t": []}], "preferred_name": "germ cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5167384", "l": "Histiocytes | Body fluid | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Histiocytes | Body fluid | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C0393073", "l": "autologous Epstein-Barr virus-specific cytotoxic T lymphocytes (cell)", "d": [], "t": []}, {"i": "NCIT:C12920", "l": "EBV-Specific Cytotoxic T-Lymphocyte", "d": ["A white blood cell that is derived from a lymphocyte stem cell matured in the thymus and characterized by a CD8 marker on the surface and an antigen-specific Epstein Barr virus T cell receptor."], "t": []}], "preferred_name": "autologous Epstein-Barr virus-specific cytotoxic T lymphocytes (cell)", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4042024", "l": "striatal PTHLH MOXD1 expressing interneuron", "d": ["A pthlh-expressing interneuron that expresses MOXD1 and has its soma in a striatum."], "t": []}], "preferred_name": "striatal PTHLH MOXD1 expressing interneuron", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5575125", "l": "JNJ 68284528", "d": [], "t": []}], "preferred_name": "JNJ 68284528", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C3898559", "l": "MAGE-A3/12-specific TCR Gene-transduced Autologous PBLs", "d": [], "t": []}, {"i": "NCIT:C116862", "l": "MAGE-A3/12-specific TCR Gene-transduced Autologous PBLs", "d": ["Human autologous peripheral blood lymphocytes (PBLs) transduced with a retroviral vector encoding a T-cell receptor (TCR) that recognizes the human melanoma antigens A3 and A12 (MAGE-A3/12), with potential antineoplastic activity. Upon isolation, transduction, expansion ex vivo, and reintroduction into the patient, the MAGE-A3/12-specific TCR gene-transduced autologous PBLs bind to and lyse tumor cells expressing MAGE-A3/12, which may halt the growth of MAGE-A3/12-expressing cancer cells. MAGE-A3 and MAGE-A12, tumor associated antigens and members of the melanoma-associated antigen gene family, are overexpressed by a variety of cancer cell types."], "t": []}], "preferred_name": "MAGE-A3/12-specific TCR Gene-transduced Autologous PBLs", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C4727036", "l": "Autologous Anti-CD19 CAR-CD3zeta-4-1BB-expressing T-cells PZ01", "d": [], "t": []}, {"i": "NCIT:C153118", "l": "Autologous Anti-CD19 CAR-CD3zeta-4-1BB-expressing T-cells PZ01", "d": ["A preparation of autologous T-lymphocytes that have been transduced with a lentiviral vector to express a chimeric antigen receptor (CAR) consisting of a single chain variable fragment (scFv) of anti-CD19, coupled to the costimulatory domains of 4-1BB (CD137) and the zeta chain of the human T-cell receptor (CD3zeta), with potential immunostimulating and antineoplastic activities. Upon transfusion, the autologous anti-CD19 CAR-CD3zeta-4-1BB-expressing T-cells PZ01 target, bind to, and induce selective toxicity in CD19-expressing B cells. The CD19 antigen is a B-cell-specific cell surface antigen expressed in all B-cell lineage malignancies."], "t": []}], "preferred_name": "Autologous Anti-CD19 CAR-CD3zeta-4-1BB-expressing T-cells PZ01", "taxa": []}
{"type": "biolink:Cell", "ic": 82.16838616155795, "identifiers": [{"i": "CL:0000906", "l": "activated CD8-positive, alpha-beta T cell", "d": ["A CD8-positive, alpha-beta T cell with the phenotype CD69-positive, CD62L-negative, CD127-negative, CD25-positive, and CCR7-negative."], "t": []}], "preferred_name": "activated CD8-positive, alpha-beta T cell", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "CL:0000862", "l": "suppressor macrophage", "d": ["A macrophage that suppresses immune responses."], "t": []}], "preferred_name": "suppressor macrophage", "taxa": []}
{"type": "biolink:Cell", "ic": 90.871710685482, "identifiers": [{"i": "CL:0002351", "l": "progenitor cell of endocrine pancreas", "d": ["A progenitor cell that is able to differentiate into the pancreas alpha, beta and delta endocrine cells. This cell type expresses neurogenin-3 and Isl-1."], "t": []}], "preferred_name": "progenitor cell of endocrine pancreas", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0002290", "l": "Y chromosome-bearing sperm cell", "d": ["A sperm bearing a Y chromosome. Chromosomal and genetic sex is established at fertilization in mammals and depends upon whether an X-bearing sperm or a Y-bearing sperm fertilizes the X-bearing ovum."], "t": []}], "preferred_name": "Y chromosome-bearing sperm cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5174092", "l": "Myeloblasts | Blood | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Myeloblasts | Blood | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0002582", "l": "visceral preadipocyte", "d": ["A preadipocyte that is part of visceral tissue."], "t": []}], "preferred_name": "visceral preadipocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1515127", "l": "T-Cell Large Granular Lymphocyte", "d": [], "t": []}, {"i": "NCIT:C38673", "l": "T-Cell Large Granular Lymphocyte", "d": ["A thymus-dependent white blood cell that has been activated by contact with antigen and has enlarged by macromolecular synthesis with presence of large granules visible by light microscopy."], "t": []}], "preferred_name": "T-Cell Large Granular Lymphocyte", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1440285", "l": "CD3+CD69+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:1373015004", "l": "", "d": [], "t": []}], "preferred_name": "CD3+CD69+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4322812", "l": "CD43+ T lymphocyte", "d": [], "t": []}], "preferred_name": "CD43+ T lymphocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4307034", "l": "Astro-NT NN_2 Fzd2 astrocyte (Mmus)", "d": ["A astrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Gja1 (Mmus), A330076C08Rik (Mmus), Sfrp5 (Mmus), Gria2 (Mmus). It is distinguished from other Astro-NT NN_2 cells by expression of Fzd2, Gria2, Ttll3. These cells are located in the Midbrain, Thalamus, Pons , in or close to the regions: Midbrain reticular nucleus . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5214 Astro-NT NN_2."], "t": []}], "preferred_name": "Astro-NT NN_2 Fzd2 astrocyte (Mmus)", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5157528", "l": "CD3-CD57+ cells | Bone marrow | Cell markers", "d": [], "t": []}], "preferred_name": "CD3-CD57+ cells | Bone marrow | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:1000443", "l": "ciliary muscle cell", "d": ["A smooth muscle cell that is part of the ciliary body."], "t": []}, {"i": "UMLS:C1182650", "l": "Ciliary muscle cell", "d": [], "t": []}], "preferred_name": "ciliary muscle cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1440289", "l": "CD3+CD8+CD45RA-CD45RO- cell", "d": [], "t": []}, {"i": "SNOMEDCT:1373269005", "l": "", "d": [], "t": []}], "preferred_name": "CD3+CD8+CD45RA-CD45RO- cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4023122", "l": "oxytocin receptor sst GABAergic cortical interneuron", "d": ["An interneuron located in the cerebral cortex that expresses the oxytocin receptor. These interneurons also express somatostatin."], "t": []}], "preferred_name": "oxytocin receptor sst GABAergic cortical interneuron", "taxa": []}
{"type": "biolink:Cell", "ic": 90.871710685482, "identifiers": [{"i": "CL:0002258", "l": "thyroid follicular cell", "d": ["An epithelial cell that is part of the thyroid follicle epithelium, with a shape that ranges from squamous when inactive to cuboidal or columnar when active, reflecting its hormonal activity. Its apical surface is lined with microvilli projecting into the colloid-filled lumen, where it synthesizes, stores, and secretes the thyroid hormones thyroxine (T4) and triiodothyronine (T3), releasing them into the bloodstream in response to thyroid-stimulating hormone (TSH)."], "t": []}], "preferred_name": "thyroid follicular cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1515889", "l": "Mouse Adrenal Subcapsular Cell", "d": [], "t": []}, {"i": "NCIT:C22638", "l": "Mouse Adrenal Subcapsular Cell", "d": [], "t": []}], "preferred_name": "Mouse Adrenal Subcapsular Cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C6056169", "l": "Autologous Hematopoietic Peripheral Blood Stem Cells", "d": [], "t": []}], "preferred_name": "Autologous Hematopoietic Peripheral Blood Stem Cells", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1955384", "l": "Spermatozoa.isolated tail", "d": [], "t": []}], "preferred_name": "Spermatozoa.isolated tail", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C4727180", "l": "Cytokine-treated Veto Cells", "d": [], "t": []}, {"i": "NCIT:C153337", "l": "Cytokine-treated Veto Cells", "d": ["A preparation of activated veto cells, with potential immunostimulating and antineoplastic activities. White blood cells (WBCs), taken from either the patient or a healthy third-party donor, are processed and ex-vivo treated with an as of yet not disclosed mix of cytokines to activate specific cytotoxic veto cells. Upon administration, the veto cells specifically target and bind to tumor or foreign cells, thereby inducing apoptosis. Veto cells are able to selectively activate the immune system to only attack and kill tumor or foreign cells upon transplantation to prevent graft-versus-host disease (GvHD)."], "t": []}], "preferred_name": "Cytokine-treated Veto Cells", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0003003", "l": "G2 retinal ganglion cell", "d": ["A mono-stratified retinal ganglion cell that has a small dendritic field and a sparse dendritic arbor with post sympatic terminals in sublaminar layer S3."], "t": []}], "preferred_name": "G2 retinal ganglion cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:1000436", "l": "epithelial cell of lacrimal sac", "d": ["An epithelial cell that is part of the lacrimal sac."], "t": []}, {"i": "UMLS:C1182619", "l": "Epithelial cell of lacrimal sac", "d": [], "t": []}], "preferred_name": "epithelial cell of lacrimal sac", "taxa": []}
{"type": "biolink:Cell", "ic": 67.18460065295824, "identifiers": [{"i": "CL:0000319", "l": "mucus secreting cell", "d": ["Any cell that is capable of some mucus secretion."], "t": []}], "preferred_name": "mucus secreting cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5155167", "l": "Blasts | Body fluid | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Blasts | Body fluid | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": 78.80476858236055, "identifiers": [{"i": "UMLS:C1514107", "l": "Neoplastic T-Immunoblast", "d": [], "t": []}, {"i": "NCIT:C37012", "l": "Neoplastic T-Immunoblast", "d": [], "t": []}], "preferred_name": "Neoplastic T-Immunoblast", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0020025", "l": "alpha retinal ganglion cell ON-sustained (Mmus)", "d": ["A retinal ganglion cell type that has a large soma and a wide, monostratified dendritic arbor that stratifies in the inner sublamina of the inner plexiform layer, with dendrites located just proximal to the inner ChAT band (Krieger et al., 2017). It shows a sustained increase in firing rate to ON stimuli (Krieger et al., 2017). It corresponds to the G24 functional type (Baden et al., 2016; Goetz et al., 2022), the C43 transcriptomic cluster (Tran et al., 2019), and is considered the mouse ortholog of the primate ON midget retinal ganglion cell (Hahn et al., 2023). It is molecularly defined by expression of Spp1, Smi32, Brn3b, Calbindin, and Tbr2 (Krieger et al., 2017; Tran et al., 2019)."], "t": []}], "preferred_name": "alpha retinal ganglion cell ON-sustained (Mmus)", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0034964", "l": "Regenerating muscle fiber", "d": [], "t": []}, {"i": "SNOMEDCT:56132000", "l": "", "d": [], "t": []}], "preferred_name": "Regenerating muscle fiber", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5221143", "l": "Leukocytes|NCnc|Pt|Dial fld", "d": [], "t": []}], "preferred_name": "Leukocytes|NCnc|Pt|Dial fld", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:2000087", "l": "dentate gyrus of hippocampal formation basket cell", "d": ["Any basket cell that is part of a dentate gyrus of hippocampal formation."], "t": []}], "preferred_name": "dentate gyrus of hippocampal formation basket cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1514161", "l": "Mouse Platelet", "d": [], "t": []}, {"i": "NCIT:C22568", "l": "Mouse Platelet", "d": [], "t": []}], "preferred_name": "Mouse Platelet", "taxa": []}
{"type": "biolink:Cell", "ic": 88.20185721311867, "identifiers": [{"i": "UMLS:C1520156", "l": "Wisconsin ES Cell Line", "d": [], "t": []}, {"i": "NCIT:C20307", "l": "Wisconsin ES Cell Line", "d": [], "t": []}], "preferred_name": "Wisconsin ES Cell Line", "taxa": []}
{"type": "biolink:Cell", "ic": 89.40238429118027, "identifiers": [{"i": "CL:4301612", "l": "newly formed oligodendrocyte (Mmus)", "d": ["A newly formed oligodendrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of 9630013A20Rik (Mmus), Ptprb (Mmus). Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Supertype:1182 NFOL NN_2."], "t": []}], "preferred_name": "newly formed oligodendrocyte (Mmus)", "taxa": []}
{"type": "biolink:Cell", "ic": 68.64266157169268, "identifiers": [{"i": "CL:0000584", "l": "enterocyte", "d": ["An epithelial cell that has its apical plasma membrane folded into microvilli to provide ample surface for the absorption of nutrients from the intestinal lumen."], "t": []}, {"i": "UMLS:C0682610", "l": "Enterocytes", "d": [], "t": []}, {"i": "NCIT:C12585", "l": "Enterocyte", "d": ["A type of epithelial cell that lines the intestines and colon. It participates in the absorption of water and nutrients from the intestinal lumen, and in the secretion of digestive enzymes."], "t": []}, {"i": "MESH:D020895", "l": "Enterocytes", "d": [], "t": []}], "preferred_name": "enterocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "CL:0002277", "l": "type I enteroendocrine cell", "d": ["An enteroendocrine cell commonest in the duodenum and jejunum, rare in ileum, that secretes cholecystokinin. This cell type is involved in the regulation of digestive enzymes and bile."], "t": []}, {"i": "UMLS:C2332713", "l": "Type I enteroendocrine cell", "d": [], "t": []}], "preferred_name": "type I enteroendocrine cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5166079", "l": "Granulocytes | Blood | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Granulocytes | Blood | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C2331938", "l": "Diploid nucleated cell", "d": [], "t": []}], "preferred_name": "Diploid nucleated cell", "taxa": []}
{"type": "biolink:Cell", "ic": 70.29748386239838, "identifiers": [{"i": "CL:0000807", "l": "DN3 thymocyte", "d": ["A thymocyte that has the phenotype CD4-negative, CD8-negative, CD44-negative, and CD25-positive and expressing the T cell receptor beta-chain in complex with the pre-T cell receptor alpha chain."], "t": []}], "preferred_name": "DN3 thymocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0009107", "l": "lymphatic endothelial cell of subcapsular sinus ceiling", "d": ["A lymphatic endothelial cell located in the subcapsular sinus ceiling of a lymph node. In human, it's characterized by a unique marker expression (NT5e+ and Caveolin-1+)."], "t": []}], "preferred_name": "lymphatic endothelial cell of subcapsular sinus ceiling", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5175648", "l": "Ovalocytes | Blood | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Ovalocytes | Blood | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4253034", "l": "Epithelial cell of prostatic urethra", "d": [], "t": []}], "preferred_name": "Epithelial cell of prostatic urethra", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0228009", "l": "Secondary spermatocyte", "d": [], "t": []}, {"i": "SNOMEDCT:3374006", "l": "", "d": [], "t": []}], "preferred_name": "Secondary spermatocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4070012", "l": "inferior cardiac neuron", "d": ["A motor neuron that controls ventral stomach grooves leading to pyloric filter."], "t": []}], "preferred_name": "inferior cardiac neuron", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4042021", "l": "neuronal-restricted precursor", "d": ["A progenitor cell of the central nervous system that differentiates exclusively onto neurons. This progenitor cell is found in a hippocampus subventricular zone, developing cortex and spinal cord of the central nervous system."], "t": []}], "preferred_name": "neuronal-restricted precursor", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5382941", "l": "Interferon-gamma producing HLA-B35 Cytomegalovirus specific CD8 cells | Blood | Cell markers", "d": [], "t": []}], "preferred_name": "Interferon-gamma producing HLA-B35 Cytomegalovirus specific CD8 cells | Blood | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5380991", "l": "Cells.CD8.HLA-A1 CMV specific.CMV antigen stimulated CD107a+b expressing", "d": [], "t": []}], "preferred_name": "Cells.CD8.HLA-A1 CMV specific.CMV antigen stimulated CD107a+b expressing", "taxa": []}
{"type": "biolink:Cell", "ic": 92.76600187037766, "identifiers": [{"i": "CL:0002325", "l": "lactocyte", "d": ["A milk-producing glandular epithelial cell that is part of a mammary gland alveolus and differentiates from a luminal adaptive secretory precursor cell during secretory differentiation (also termed lactogenesis I). Following secretory activation (also termed lactogenesis II), a lactocyte is involved in the synthesis and/or transport of milk constituents including proteins, oligosaccharides, lactose, micronutrients, fat, hormones, immunoglobulins, and cytokines into the lumen of the lactating mammary gland."], "t": []}], "preferred_name": "lactocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4072018", "l": "pacemaker neuron", "d": ["A neuron that generates rhythmic bursts of action potentials independently of synaptic input. This intrinsic property enables it to maintain oscillatory activity even when isolated from other neurons. It populates the brainstem, hypothalamus, basal ganglia, spinal cord, and cerebellum. It plays a crucial role in regulating circadian rhythms in the suprachiasmatic nucleus, generating respiratory rhythms in the preBötzinger complex, and synchronizing neural networks."], "t": []}], "preferred_name": "pacemaker neuron", "taxa": []}
{"type": "biolink:Cell", "ic": 92.76600187037766, "identifiers": [{"i": "CL:0002462", "l": "adipose dendritic cell", "d": ["A F4/80-negative dendritic cell located in adipose tissue."], "t": []}], "preferred_name": "adipose dendritic cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0000532", "l": "CAP motoneuron", "d": ["A primary motor neuron with its soma in the caudal region of a spinal cord. The axon of this motoneuron exit the spinal cord from one single point and innervates the lateral surface of ventral axial muscles"], "t": []}], "preferred_name": "CAP motoneuron", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4322673", "l": "CD8+HLA-DR+ T lymphocyte", "d": [], "t": []}], "preferred_name": "CD8+HLA-DR+ T lymphocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C4744702", "l": "Autologous Anti-CD19 CAR TCR-zeta/4-1BB-transduced T-lymphocytes huCART19", "d": [], "t": []}, {"i": "NCIT:C156271", "l": "Autologous Anti-CD19 CAR TCR-zeta/4-1BB-transduced T-lymphocytes huCART19", "d": ["Autologous T-lymphocytes that have been transduced with a lentiviral vector to express a chimeric antigen receptor (CAR) consisting of a humanized single chain variable fragment (scFv) of anti-CD19 coupled to the cytoplasmic portion of the zeta chain of the human T-cell receptor (CD3zeta) and the co-stimulatory molecule 4-1BB (CD137), with potential immunostimulating and antineoplastic activities. Upon re-introduction into the patient, the autologous anti-CD19 CAR TCR-zeta/4-1BB-transduced T-lymphocytes huCART19 target and bind to CD19-expressing neoplastic B-cells. This results in a cytotoxic T-lymphocyte (CTL) response against CD19-expressing tumor cells, resulting in tumor cell lysis. CD19 (cluster of differentiation 19) is a B-cell-specific cell surface antigen overexpressed in B-cell lineage tumors. Incorporation of the co-stimulatory signaling domains increases human T-cell function, expansion, and survival."], "t": []}], "preferred_name": "Autologous Anti-CD19 CAR TCR-zeta/4-1BB-transduced T-lymphocytes huCART19", "taxa": []}
{"type": "biolink:Cell", "ic": 87.18682603146104, "identifiers": [{"i": "CL:0000648", "l": "kidney granular cell", "d": ["A smooth muscle cell that synthesizes, stores, and secretes the enzyme renin. This cell type are located in the wall of the afferent arteriole at the entrance to the glomerulus. While having a different origin than other kidney smooth muscle cells, this cell type expresses smooth muscle actin upon maturation."], "t": []}, {"i": "UMLS:C0227650", "l": "Juxtaglomerular cell", "d": [], "t": []}, {"i": "NCIT:C13161", "l": "Juxtaglomerular Cell", "d": ["Any of a group of cells that are situated in the wall of each afferent arteriole of a kidney glomerulus near its point of entry adjacent to a macula densa and that produce and secrete renin."], "t": []}, {"i": "SNOMEDCT:56196004", "l": "", "d": [], "t": []}], "preferred_name": "kidney granular cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4079017", "l": "lumbar dorsal root ganglion RET neuron", "d": ["A non-peptidergic nociceptor whose soma is located in the lumbar dorsal root ganglion and that expresses the receptor tyrosine kinase RET (encoded by RET). This neuron is distinguished from peptidergic nociceptors by its dependence on glial cell-derived neurotrophic factor family ligands rather than nerve growth factor, and in rodents it characteristically binds isolectin B4. In human DRG, RET-immunoreactive neurons constitute approximately 46% of TrkA-positive neurons, a significantly higher proportion than the 23% observed in mouse (Rostock et al. 2018, PMID:29229553), indicating an expanded non-peptidergic nociceptor compartment in humans."], "t": []}], "preferred_name": "lumbar dorsal root ganglion RET neuron", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C3640934", "l": "Adenovirus Encoding Tyrosinase/MART-1/MAGEA6-transduced Autologous Dendritic Cell Vaccine", "d": [], "t": []}, {"i": "NCIT:C102753", "l": "Adenovirus Encoding Tyrosinase/MART-1/MAGEA6-transduced Autologous Dendritic Cell Vaccine", "d": ["A cell-based cancer vaccine composed of autologous dendritic cells (DCs) transduced with a recombinant adenoviral vector encoding three full length human melanoma associated antigens (MAAs), tyrosinase, melan-A (MART-1) and the melanoma antigen A6 (MAGEA6), with potential antineoplastic activity. Upon intradermal administration, adenovirus encoding tyrosinase/MART-1/MAGEA6-transduced autologous DC vaccine may stimulate a cytotoxic T lymphocyte (CTL) response against tyrosinase/MART-1/MAGEA6-positive tumor cells, which may result in tumor cell death and decreased tumor growth. Tyrosinase, a melanoma-specific differentiation antigen, catalyzes the first step of melanin synthesis in melanocytes. Vaccination with multi-antigen modified DC may improve the efficacy of the DC immunotherapy."], "t": []}], "preferred_name": "Adenovirus Encoding Tyrosinase/MART-1/MAGEA6-transduced Autologous Dendritic Cell Vaccine", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:1000382", "l": "type 2 vestibular sensory cell of stato-acoustic epithelium", "d": ["A type II vestibular sensory cell that is part of the stato-acoustic epithelium."], "t": []}, {"i": "UMLS:C2340517", "l": "Type 2 vestibular sensory cell of stato-acoustic epithelium", "d": [], "t": []}], "preferred_name": "type 2 vestibular sensory cell of stato-acoustic epithelium", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0002445", "l": "Ly49D-negative natural killer cell, mouse", "d": ["A NK1.1-positive T cell that is Ly49D-negative."], "t": []}], "preferred_name": "Ly49D-negative natural killer cell, mouse", "taxa": []}
{"type": "biolink:Cell", "ic": 89.40238429118027, "identifiers": [{"i": "CL:0011101", "l": "chorionic trophoblast cell", "d": ["Cells of the uterine chorion that acquire specialized structural and/or functional features that characterize chorionic trophoblasts. These cells will migrate towards the spongiotrophoblast layer and give rise to syncytiotrophoblasts of the labyrinthine layer."], "t": []}], "preferred_name": "chorionic trophoblast cell", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "CL:0002023", "l": "CD34-positive, CD41-positive, CD42-positive megakaryocyte progenitor cell", "d": ["A megakaroycotye progenitor cell that is CD34-positive, CD41-positive and CD42-positive on the cell surface."], "t": []}], "preferred_name": "CD34-positive, CD41-positive, CD42-positive megakaryocyte progenitor cell", "taxa": []}
{"type": "biolink:Cell", "ic": 84.83823963392128, "identifiers": [{"i": "CL:0002393", "l": "intermediate monocyte", "d": ["A monocyte that has characteristics of both patrolling and inflammatory monocytes."], "t": []}], "preferred_name": "intermediate monocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 83.63771255585968, "identifiers": [{"i": "CL:0002354", "l": "yolk sac hematopoietic stem cell", "d": ["A hematopoietic stem found in the yolk sac. In mice, this cell type is Sca-1-negative, CD45-negative, MHC-negative, HSA-positive, AA4.1-positive, CD44-positive."], "t": []}], "preferred_name": "yolk sac hematopoietic stem cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C0282560", "l": "Caco-2 Cells", "d": [], "t": []}, {"i": "NCIT:C12912", "l": "Caco-2 Cell", "d": ["Human colonic adenocarcinoma cells that express features characteristic of mature intestinal cells, including enterocytes or mucus cells, which are used as in vitro models for studies investigating intestinal cell function and differentiation."], "t": []}, {"i": "MESH:D018938", "l": "Caco-2 Cells", "d": [], "t": []}], "preferred_name": "Caco-2 Cells", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5157236", "l": "CD10 blasts | XXX | Cell markers", "d": [], "t": []}], "preferred_name": "CD10 blasts | XXX | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5983483", "l": "Lasmecabtagene Timgedleucel", "d": [], "t": []}, {"i": "NCIT:C211698", "l": "Lasmecabtagene Timgedleucel", "d": [], "t": []}], "preferred_name": "Lasmecabtagene Timgedleucel", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5666853", "l": "Allogeneic iC9/CD19-CAR-CD28-zeta-2A-IL15-transduced Cord Blood-derived Natural Killer Cells TAK-007", "d": [], "t": []}], "preferred_name": "Allogeneic iC9/CD19-CAR-CD28-zeta-2A-IL15-transduced Cord Blood-derived Natural Killer Cells TAK-007", "taxa": []}
{"type": "biolink:Cell", "ic": 64.07851691443369, "identifiers": [{"i": "CL:1001610", "l": "bone marrow hematopoietic cell", "d": ["Hematopoietic cells resident in the bone marrow. Include: hematopoietic stem cells (lymphoid stem cells and myeloid stem cells) and the precursor cells for thrombocytes, erythrocytes, basophils, neutrophils, eosinophils, monocytes and lymphocytes."], "t": []}], "preferred_name": "bone marrow hematopoietic cell", "taxa": []}
{"type": "biolink:Cell", "ic": 44.79937401875995, "identifiers": [{"i": "CL:0000219", "l": "motile cell", "d": ["A cell that moves by its own activities."], "t": []}], "preferred_name": "motile cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5854540", "l": "Autologous Anti-CD79b CAR-T Cells JV-213", "d": [], "t": []}, {"i": "NCIT:C200460", "l": "Autologous Anti-CD79b CAR-T Cells JV-213", "d": ["A preparation of autologous T-lymphocytes that have been genetically modified to express a chimeric antigen receptor (CAR) targeting the tumor-associated antigen (TAA) B-cell antigen receptor complex-associated protein beta chain (CD79b; B-cell-specific glycoprotein B29), with potential immunostimulating and antineoplastic activities. Upon administration, autologous anti-CD79b CAR-T cells JV-213 target and bind to CD79b-expressing tumor cells, thereby inducing selective toxicity in CD79b-expressing tumor cells. CD79b, a critical receptor for successful B-cell development and part of the B-cell receptor (BCR) signaling complex, is widely expressed in certain subtypes of B-cell lymphomas."], "t": []}], "preferred_name": "Autologous Anti-CD79b CAR-T Cells JV-213", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1317736", "l": "Progressive spermatozoa", "d": [], "t": []}, {"i": "SNOMEDCT:726586008", "l": "", "d": [], "t": []}], "preferred_name": "Progressive spermatozoa", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5691291", "l": "Peyer's Patch M Cells", "d": [], "t": []}], "preferred_name": "Peyer's Patch M Cells", "taxa": []}
{"type": "biolink:Cell", "ic": 66.1438480758483, "identifiers": [{"i": "CL:0000136", "l": "adipocyte", "d": ["A fat-storing cell found mostly in the abdominal cavity and subcutaneous tissue of mammals. Fat is usually stored in the form of triglycerides."], "t": []}, {"i": "UMLS:C0206131", "l": "Adipocytes", "d": [], "t": []}, {"i": "NCIT:C12556", "l": "Adipocyte", "d": ["A connective tissue cell that is specialized to synthesize and store fat."], "t": []}, {"i": "MESH:D017667", "l": "Adipocytes", "d": [], "t": []}, {"i": "SNOMEDCT:24826007", "l": "", "d": [], "t": []}], "preferred_name": "adipocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 86.30756602822301, "identifiers": [{"i": "CL:0002066", "l": "Feyrter cell", "d": ["A neuroendocrine cell found in the epithelium of the lungs and respiratory tract. This cell type is rounded or elliptical in shape, situated mainly in the basal part of the epithelium; regulates bronchial secretion, smooth muscle contraction, lobular growth, ciliary activity and chemoreception. Cell has an electron-lucent cytoplasm, contains numerous dense-cored vesicles with a clear halo between the core and the limiting membrane."], "t": []}], "preferred_name": "Feyrter cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4033168", "l": "pelvic ganglion TH/DBH neuron", "d": ["A sympathetic neuron that has the soma located in the pelvic ganglion and expresses the marker tyrosine hydroxylase (TH) and dopamine beta-hydroxylase (DBH)."], "t": []}], "preferred_name": "pelvic ganglion TH/DBH neuron", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5157595", "l": "CD5 cells | Blood | Cell markers", "d": [], "t": []}], "preferred_name": "CD5 cells | Blood | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5703599", "l": "LentiGlobin BB305", "d": [], "t": []}], "preferred_name": "LentiGlobin BB305", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:1000718", "l": "kidney inner medulla collecting duct principal cell", "d": ["Any renal principal cell that is part of some inner medullary collecting duct."], "t": []}], "preferred_name": "kidney inner medulla collecting duct principal cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5382938", "l": "Interferon-gamma producing Cytomegalovirus-specific CD8 cells | Blood | Cell markers", "d": [], "t": []}], "preferred_name": "Interferon-gamma producing Cytomegalovirus-specific CD8 cells | Blood | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0487156", "l": "Lymphocyte positive for both CD5 antigen and CD19 antigen", "d": [], "t": []}, {"i": "SNOMEDCT:117532000", "l": "", "d": [], "t": []}], "preferred_name": "Lymphocyte positive for both CD5 antigen and CD19 antigen", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1518751", "l": "Mouse Ovarian Germ Cell", "d": [], "t": []}, {"i": "NCIT:C22659", "l": "Mouse Ovarian Germ Cell", "d": [], "t": []}], "preferred_name": "Mouse Ovarian Germ Cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5171662", "l": "Lymphocytes | Fetus | Pleural fluid | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Lymphocytes | Fetus | Pleural fluid | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5854360", "l": "Autologous CAR-T Cells B4T2-001", "d": [], "t": []}, {"i": "NCIT:C198687", "l": "Autologous CAR-T Cells B4T2-001", "d": ["A preparation of autologous T-lymphocytes that have been genetically modified to express a chimeric antigen receptor (CAR) specific for the tumor-associated antigen (TAA) BT-001, with potential immunostimulating and antineoplastic activities. Upon administration, autologous CAR-T cells B4T2-001 target and bind to BT-001-expressing tumor cells. This results in a cytotoxic T-lymphocyte (CTL) response against the tumor cells, the release of cytotoxic molecules and the induction of tumor cell lysis. BT-001, a tumor self-antigen, is overexpressed in certain tumor cell types, and plays a key role in tumor migration, invasion, and metastasis."], "t": []}], "preferred_name": "Autologous CAR-T Cells B4T2-001", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5236007", "l": "FT516", "d": [], "t": []}, {"i": "NCIT:C164140", "l": "iPSC-derived CD16-expressing Natural Killer Cells FT516", "d": ["An allogeneic, off-the-shelf, natural killer (NK) cell product derived from a clonal master induced pluripotent stem cell (iPSC) line, and engineered to express a high-affinity, non-cleavable CD16 (hnCD16) Fc receptor, with potential antineoplastic and immunostimulatory activities. Upon administration, iPSC-derived CD16-expressing NK cells FT516 bind to the Fc portion of tumor cell-bound monoclonal antibodies and activate NK cell activation, cytokine secretion and antibody-dependent cellular cytotoxicity (ADCC). CD16, also known as Fc-gamma receptor III, is normally expressed on the surface of NK cells, neutrophils, monocytes and macrophages, and plays a key role in initiating ADCC. It is often downregulated in certain cancers, thereby inhibiting the anti-tumor immune response. FT516 NK cells' hnCD16 Fc receptor prevents downregulation and optimizes binding to tumor-targeting antibodies for enhanced ADCC."], "t": []}], "preferred_name": "FT516", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1268010", "l": "Megakaryocytic cell", "d": [], "t": []}, {"i": "SNOMEDCT:127918005", "l": "", "d": [], "t": []}], "preferred_name": "Megakaryocytic cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4307114", "l": "ABC NN_1 Dapl1 arachnoid barrier cell (Mmus)", "d": ["A arachnoid barrier cell of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Slc47a1 (Mmus), Dapl1 (Mmus). It is distinguished from other ABC NN cells by expression of Dapl1. These cells are located in the brain . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5294 ABC NN_1."], "t": []}], "preferred_name": "ABC NN_1 Dapl1 arachnoid barrier cell (Mmus)", "taxa": []}
{"type": "biolink:Cell", "ic": 65.84278220428874, "identifiers": [{"i": "CL:0002274", "l": "histamine secreting cell", "d": ["A cell type that secretes histamine."], "t": []}], "preferred_name": "histamine secreting cell", "taxa": []}
{"type": "biolink:Cell", "ic": 71.93166454101878, "identifiers": [{"i": "CL:0002088", "l": "interstitial cell of Cajal", "d": ["This is a cell found in the gastrointestinal tract of mammals and serves as a pacemaker that triggers gut contraction. ICCs mediate inputs from the enteric nervous system to smooth muscle cells and are thought to be the cells from which gastrointestinal stromal tumors (GISTs) arise."], "t": []}, {"i": "UMLS:C1512901", "l": "Interstitial Cells of Cajal", "d": [], "t": []}, {"i": "NCIT:C32871", "l": "Interstitial Cell of Cajal", "d": ["A specialized cell found throughout the gastrointestinal tract. These cells are essential for normal gastrointestinal motility by functioning as the pacemaker cells in gastrointestinal muscles. They mediate or transduce inputs from enteric motor nerves to the smooth muscle syncytium."], "t": []}, {"i": "MESH:D056885", "l": "Interstitial Cells of Cajal", "d": [], "t": []}, {"i": "SNOMEDCT:1156991003", "l": "", "d": [], "t": []}], "preferred_name": "interstitial cell of Cajal", "taxa": []}
{"type": "biolink:Cell", "ic": 67.60355479150275, "identifiers": [{"i": "CL:0002374", "l": "ear hair cell", "d": ["A hair cell of the ear that contains the organs of balance and hearing."], "t": []}], "preferred_name": "ear hair cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5448048", "l": "UWC 19", "d": [], "t": []}], "preferred_name": "UWC 19", "taxa": []}
{"type": "biolink:Cell", "ic": 90.871710685482, "identifiers": [{"i": "CL:4023050", "l": "L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex", "d": ["An intratelencephalic-projecting glutamatergic neuron with a soma found in L6 of the primary motor cortex. These cells are short untufted pyramidal cells, which could be stellate or inverted."], "t": []}], "preferred_name": "L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0229660", "l": "Promyelomonocyte", "d": [], "t": []}, {"i": "SNOMEDCT:68936005", "l": "", "d": [], "t": []}], "preferred_name": "Promyelomonocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 87.18682603146104, "identifiers": [{"i": "CL:0002638", "l": "bronchioalveolar stem cell", "d": ["A respiratory stem cell found at the junction of the terminal (conductive) bronchiole and the respiratory bronchiole. This cell types gives rise to alveolar cell types and club cells in response to lung injury. This cell type expresses markers Scgb1a1 and Sftpc."], "t": []}], "preferred_name": "bronchioalveolar stem cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C4745321", "l": "Young Autologous Tumor-infiltrating Lymphocytes", "d": [], "t": []}, {"i": "NCIT:C156481", "l": "Young Autologous Tumor-infiltrating Lymphocytes", "d": ["A preparation of autologous young tumor infiltrating lymphocytes (TILs), that are isolated from the patient's tumor tissue and minimally cultured ex vivo, with potential antineoplastic and immunomodulating activities. Upon re-administration of the young TILs, the TILs re-infiltrate the tumor, recognize the tumor cells and initiate tumor cell lysis. This inhibits tumor cell growth."], "t": []}], "preferred_name": "Young Autologous Tumor-infiltrating Lymphocytes", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5706372", "l": "Anti-BCMA/Anti-GPRC5D CAR-T Cells OriC321", "d": [], "t": []}, {"i": "NCIT:C187125", "l": "Anti-BCMA/Anti-GPRC5D CAR-T Cells OriC321", "d": ["A preparation of T-lymphocytes engineered to express chimeric antigen receptor(s) (CAR) targeting the human tumor-associated antigens (TAAs) B-cell maturation antigen (BCMA; tumor necrosis factor receptor superfamily member 17; TNFRSF17) and G-protein coupled receptor family C group 5 member D (GPRC5D) and fused to as of yet not fully elucidated co-stimulatory domains, with potential immunostimulating and antineoplastic activities. Upon administration, the anti-BCMA/anti-GPRC5D CAR-T cells OriC321 specifically and simultaneously target and bind to tumor cells expressing BCMA and/or GPRC5D. This induces selective toxicity in tumor cells that express BCMA and/or GPRC5D. BCMA, a receptor for both a proliferation-inducing ligand (APRIL) and B-cell activating factor (BAFF), is a member of the tumor necrosis factor receptor superfamily (TNFRSF). BCMA is found on the surfaces of plasma cells, is overexpressed on malignant plasma cells and plays a key role in plasma cell proliferation and survival. GPRC5D is overexpressed in certain malignancies, such as multiple myeloma, while minimally expressed in normal, healthy cells. It plays a key role in tumor cell proliferation."], "t": []}], "preferred_name": "Anti-BCMA/Anti-GPRC5D CAR-T Cells OriC321", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1518683", "l": "Cochlear outer hair cell", "d": [], "t": []}, {"i": "NCIT:C33233", "l": "Outer Hair Cell of the Organ of the Corti", "d": ["A cell situated on one of three of the most outer layers of the basilar membrane of the cochlea. Each cell has multiple, sensitive strands called stereocilia. In the resting state the stereocilia are leaning on each other in a conical bundle and are embedded in the tectorial membrane. When the cochlea moves in response to sound, a slight shearing force occurs between the basilar and tectorial membranes, the stereocilia bend and send electrical impulses to the brain via the eighth cranial nerve."], "t": []}, {"i": "MESH:D018072", "l": "Hair Cells, Auditory, Outer", "d": [], "t": []}, {"i": "SNOMEDCT:43313002", "l": "", "d": [], "t": []}], "preferred_name": "Cochlear outer hair cell", "taxa": []}
{"type": "biolink:Cell", "ic": 83.63771255585968, "identifiers": [{"i": "CL:0002418", "l": "hemangioblast", "d": ["A pluripotent cell in the yolk sac that can give rise to mesenchymal cells including erythrocytes and endothelial cells."], "t": []}], "preferred_name": "hemangioblast", "taxa": []}
{"type": "biolink:Cell", "ic": 92.76600187037766, "identifiers": [{"i": "UMLS:C1514188", "l": "Pochon ES Cell Line", "d": [], "t": []}, {"i": "NCIT:C20284", "l": "Pochon ES Cell Line", "d": [], "t": []}], "preferred_name": "Pochon ES Cell Line", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0002057", "l": "CD14-positive, CD16-negative classical monocyte", "d": ["A classical monocyte that is CD14-positive, CD16-negative, CD64-positive, CD163-positive."], "t": []}], "preferred_name": "CD14-positive, CD16-negative classical monocyte", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5148040", "l": "Monocytes.CD14", "d": [], "t": []}], "preferred_name": "Monocytes.CD14", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "UMLS:C4284002", "l": "Type 1 Regulatory T-Cell", "d": [], "t": []}, {"i": "NCIT:C126755", "l": "Type 1 Regulatory T-Cell", "d": ["A population of CD4+, CD25-, and FoxP3- T-lymphocytes that are involved in immunotolerance. These cells secrete the immunosuppressive cytokines, tumor growth factor-beta (TGF-B) and interleukin-10, and may induce cell cycle arrest or apoptosis in effector T-cells."], "t": []}], "preferred_name": "Type 1 Regulatory T-Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4033000", "l": "endothelial cell of venule of lymph node", "d": ["A(n) endothelial cell that is part of a(n) venule of lymph node."], "t": []}], "preferred_name": "endothelial cell of venule of lymph node", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "CL:0002195", "l": "hepatic stem cell", "d": ["A stem cell that can give rise to the cells of the liver. The term usually refers to the self-renewing pool of hepatocyte precursors in the adult liver (differently from 'hepatoblast', often used for fetal precursors of hepatocytes)."], "t": []}, {"i": "UMLS:C1517917", "l": "Hepatic stem cell", "d": [], "t": []}, {"i": "NCIT:C12960", "l": "Liver Stem Cell", "d": ["An undifferentiated cell found in the liver."], "t": []}], "preferred_name": "hepatic stem cell", "taxa": []}
{"type": "biolink:Cell", "ic": 83.11065783093733, "identifiers": [{"i": "UMLS:C1513945", "l": "Neoplastic Cuboidal Cell", "d": [], "t": []}, {"i": "NCIT:C42082", "l": "Neoplastic Cuboidal Cell", "d": [], "t": []}], "preferred_name": "Neoplastic Cuboidal Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 76.40371442623734, "identifiers": [{"i": "CL:4030065", "l": "L6 intratelencephalic projecting glutamatergic neuron", "d": ["A transcriptomically distinct intratelencephalic-projecting glutamatergic neuron with a soma found in L6 of the primary motor cortex. These cells are short untufted pyramidal cells, which could be stellate or inverted.", "A transcriptomically distinct intratelencephalic-projecting glutamatergic neuron with a soma found in L6 of the primary motor cortex. These cells are short untufted pyramidal cells, which could be stellate or inverted.  The standard transcriptomic reference data for this cell type can be found on the CellxGene census under the collection: 'Transcriptomic cytoarchitecture reveals principles of human neocortex organization', dataset: 'Supercluster: IT-projecting excitatory neurons', Author Categories: 'CrossArea_subclass', L6 IT."], "t": []}], "preferred_name": "L6 intratelencephalic projecting glutamatergic neuron", "taxa": []}
{"type": "biolink:Cell", "ic": 70.82453858732072, "identifiers": [{"i": "CL:2000001", "l": "peripheral blood mononuclear cell", "d": ["A leukocyte with a single non-segmented nucleus in the mature form found in the circulatory pool of blood."], "t": []}], "preferred_name": "peripheral blood mononuclear cell", "taxa": []}
{"type": "biolink:Cell", "ic": 92.76600187037766, "identifiers": [{"i": "CL:0004138", "l": "retinal ganglion cell A2", "d": ["A retinal ganglion A cell with dense arbor near soma."], "t": []}], "preferred_name": "retinal ganglion cell A2", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "CL:0002443", "l": "Ly49CI-positive natural killer cell, mouse", "d": ["A NK1.1-positive T cell that is Ly49Cl-positive."], "t": []}], "preferred_name": "Ly49CI-positive natural killer cell, mouse", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5216309", "l": "Platelets|NCnc|Pt|Plas", "d": [], "t": []}], "preferred_name": "Platelets|NCnc|Pt|Plas", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1267945", "l": "Lymphocyte positive for CD53 antigen", "d": [], "t": []}, {"i": "SNOMEDCT:117388008", "l": "", "d": [], "t": []}], "preferred_name": "Lymphocyte positive for CD53 antigen", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5157490", "l": "CD34 blasts | Blood | Cell markers", "d": [], "t": []}], "preferred_name": "CD34 blasts | Blood | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": 61.71587572209587, "identifiers": [{"i": "CL:0000700", "l": "dopaminergic neuron", "d": ["A neuron that releases dopamine as a neurotransmitter."], "t": []}], "preferred_name": "dopaminergic neuron", "taxa": []}
{"type": "biolink:Cell", "ic": 84.21065366064373, "identifiers": [{"i": "CL:0002180", "l": "mucous cell of stomach", "d": ["An epithelial cell of the stomach. This cell produces mucous."], "t": []}, {"i": "UMLS:C1179683", "l": "Mucous cell of stomach", "d": [], "t": []}], "preferred_name": "mucous cell of stomach", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0002104", "l": "IgG-negative double negative memory B cell", "d": ["An IgG-negative double negative memory B cell is a double negative memory B cell with the phenotype IgG-negative, IgD-negative, and CD27-negative."], "t": []}], "preferred_name": "IgG-negative double negative memory B cell", "taxa": []}
{"type": "biolink:Cell", "ic": 88.20185721311867, "identifiers": [{"i": "UMLS:C1709197", "l": "Neoplastic Schwann-Like Cell", "d": [], "t": []}, {"i": "NCIT:C48594", "l": "Neoplastic Schwann-Like Cell", "d": [], "t": []}], "preferred_name": "Neoplastic Schwann-Like Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 90.871710685482, "identifiers": [{"i": "CL:0010022", "l": "cardiac neuron", "d": ["A neuron that has its soma in the heart."], "t": []}], "preferred_name": "cardiac neuron", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5157465", "l": "CD3+HLA-DR+ cells | Blood | Cell markers", "d": [], "t": []}], "preferred_name": "CD3+HLA-DR+ cells | Blood | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1267836", "l": "Lymphocyte positive for both CD3 antigen and IL2R1 antigen", "d": [], "t": []}, {"i": "SNOMEDCT:117526005", "l": "", "d": [], "t": []}], "preferred_name": "Lymphocyte positive for both CD3 antigen and IL2R1 antigen", "taxa": []}
{"type": "biolink:Cell", "ic": 84.83823963392128, "identifiers": [{"i": "CL:1000303", "l": "fibroblast of areolar connective tissue", "d": ["A fibroblast that is part of the areolar connective tissue."], "t": []}, {"i": "UMLS:C2336699", "l": "Fibroblast of areolar connective tissue", "d": [], "t": []}], "preferred_name": "fibroblast of areolar connective tissue", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1511462", "l": "CY10", "d": [], "t": []}, {"i": "NCIT:C20245", "l": "CY10", "d": ["Provider: CyThera, Inc., San Diego, CA. No information from provider. This cell line meets the criteria for the use of human embryonic stem cells by federally funded researchers."], "t": []}], "preferred_name": "CY10", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "UMLS:C1513936", "l": "Neoplastic Cerebriform T-Prolymphocyte", "d": [], "t": []}, {"i": "NCIT:C39572", "l": "Neoplastic Cerebriform T-Prolymphocyte", "d": [], "t": []}], "preferred_name": "Neoplastic Cerebriform T-Prolymphocyte", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5171658", "l": "Lymphocytes | Blood cord | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Lymphocytes | Blood cord | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1440358", "l": "CD8+CD56+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:1373068005", "l": "", "d": [], "t": []}], "preferred_name": "CD8+CD56+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5966038", "l": "CC-95266", "d": [], "t": []}], "preferred_name": "CC-95266", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5382750", "l": "CD107a+b expressing HLA-B8 Cytomegalovirus specific CD8 cells | Blood | Cell markers", "d": [], "t": []}], "preferred_name": "CD107a+b expressing HLA-B8 Cytomegalovirus specific CD8 cells | Blood | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0000479", "l": "vasopressin stimulating hormone secreting cell", "d": ["A peptide hormone secreting cell that secretes vasopressin stimulating hormone"], "t": []}], "preferred_name": "vasopressin stimulating hormone secreting cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4307067", "l": "alpha2-tanycyte (Mmus)", "d": ["A alpha2-tanycyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Pdzph1 (Mmus), Wdr63 (Mmus), Dscaml1 (Mmus), P3h2 (Mmus). It is distinguished from other Tanycyte NN_2 cells by expression of Dscaml1, P3h2. These cells are located in the Hypothalamus , in or close to the regions: Periventricular hypothalamic nucleus, posterior part, Arcuate hypothalamic nucleus . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5247 Tanycyte NN_2."], "t": []}], "preferred_name": "alpha2-tanycyte (Mmus)", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4329369", "l": "Autologous Cytokine-induced Killer Cells", "d": [], "t": []}], "preferred_name": "Autologous Cytokine-induced Killer Cells", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C3829190", "l": "MART-1 Reactive CD8+ T-lymphocytes", "d": [], "t": []}, {"i": "NCIT:C111683", "l": "MART-1 Reactive CD8+ T-lymphocytes", "d": ["Human CD8-positive T-lymphocytes that are engineered to recognize melanoma tumor associated antigen MART-1 (Melanoma Antigen Recognized by T cells, also called Melan-A) in a human leukocyte antigen (HLA)-A2-restricted manner, with potential antineoplastic activity. Human peripheral blood lymphocytes (PBLs) are isolated from a melanoma patient, exposed to the MART-1:27-35(27L) peptide and MART-1 specific T-lymphocytes are isolated and expanded. Upon infusion, these lymphocytes recognize and exert a cytotoxic T-cell-mediated immune response against MART-1-expressing melanoma cells. The synthetic MART-1:27-35 HLA-A2-restricted peptide has an amino acid substitution, leucine to alanine at position 27, to increase its immunogenicity."], "t": []}], "preferred_name": "MART-1 Reactive CD8+ T-lymphocytes", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5170921", "l": "Leukocytes | Bone marrow | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Leukocytes | Bone marrow | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1278781", "l": "Entire thyroid parafollicular cell", "d": [], "t": []}, {"i": "SNOMEDCT:176770005", "l": "", "d": [], "t": []}], "preferred_name": "Entire thyroid parafollicular cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1440268", "l": "CD19+lambda+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:732278001", "l": "", "d": [], "t": []}], "preferred_name": "CD19+lambda+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0005021", "l": "mesenchymal lymphangioblast", "d": ["Mesenchymal derived lymphatic progenitor cells that give rise to the superficial lymphatics."], "t": []}], "preferred_name": "mesenchymal lymphangioblast", "taxa": []}
{"type": "biolink:Cell", "ic": 90.871710685482, "identifiers": [{"i": "CL:0002361", "l": "primitive erythroid progenitor", "d": ["A progenitor cell that is capable of forming colonies of primitive erythrocytes in the blood island of the yolk sac. First arrive at E7.5 in mouse and expresses CD41."], "t": []}], "preferred_name": "primitive erythroid progenitor", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5962747", "l": "KYV-101", "d": [], "t": []}, {"i": "NCIT:C210038", "l": "Autologous Anti-CD19 CAR-CD8alpha-CD28-CD3zeta T Cells KYV 101", "d": ["A preparation of autologous CD4- and CD8-positive T-cells that are transduced with a lentiviral vector encoding for a chimeric antigen receptor (CAR) consisting of a human single chain variable fragment (scFv) of anti-CD19 and fused to the hinge and transmembrane domains of CD8alpha co-receptor, the cytoplasmic costimulatory domain of human CD28, and the T-cell antigen receptor complex zeta chain (CD3-zeta), with potential immunostimulating activity. Upon transfusion, autologous anti-CD19 CAR-CD8alpha-CD28-CD3zeta T cells KYV 101 recognize and induce selective toxicity and lysis in CD19-expressing B-cells. CD19, a B-cell-specific cell surface antigen, is overexpressed in B-cell lineage malignancies and in certain B-cell-driven autoimmune diseases."], "t": []}], "preferred_name": "KYV-101", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C2953241", "l": "Interdigitating dendritic cell of lymph node", "d": [], "t": []}], "preferred_name": "Interdigitating dendritic cell of lymph node", "taxa": []}
{"type": "biolink:Cell", "ic": 85.53200374075534, "identifiers": [{"i": "CL:0000705", "l": "R6 photoreceptor cell", "d": [], "t": []}], "preferred_name": "R6 photoreceptor cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1515149", "l": "TE07", "d": [], "t": []}, {"i": "NCIT:C20302", "l": "TE07", "d": ["Provider: Technion University, Haifa, Israel. No information from provider. This cell line meets the criteria for the use of human embryonic stem cells by federally funded researchers."], "t": []}], "preferred_name": "TE07", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5157601", "l": "CD5+CD25+ cells | Blood | Cell markers", "d": [], "t": []}], "preferred_name": "CD5+CD25+ cells | Blood | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5556651", "l": "Autologous Memory Cytokine-enriched Natural Killer Cells", "d": [], "t": []}, {"i": "NCIT:C180827", "l": "Autologous Memory Cytokine-enriched Natural Killer Cells", "d": ["A population of cryopreserved, autologous CD56-positive memory cytokine-enriched natural killer (NK) cells (m-ceNKs), armed with NK cell-activating surface receptors, with potential immunomodulating and antitumor activities. Autologous NK cells are pre-activated ex vivo with a cytokine cocktail, which induces the differentiation of the NK cells into immune-memory m-ceNKs, which possess a unique phenotype. The pretreated NKs exhibit enhanced cytotoxicity and increased interferon-gamma (IFN-g) production. Upon administration, the autologous m-ceNKs may recognize and kill tumor cells."], "t": []}], "preferred_name": "Autologous Memory Cytokine-enriched Natural Killer Cells", "taxa": []}
{"type": "biolink:Cell", "ic": 86.30756602822301, "identifiers": [{"i": "CL:0004252", "l": "medium field retinal amacrine cell", "d": ["An amicrine that has a medium dendritic field."], "t": []}], "preferred_name": "medium field retinal amacrine cell", "taxa": []}
{"type": "biolink:Cell", "ic": 89.40238429118027, "identifiers": [{"i": "UMLS:C1882049", "l": "Neoplastic Epithelial Large Polygonal Cell", "d": [], "t": []}, {"i": "NCIT:C61000", "l": "Neoplastic Epithelial Large Polygonal Cell", "d": [], "t": []}], "preferred_name": "Neoplastic Epithelial Large Polygonal Cell", "taxa": []}
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{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1267838", "l": "Lymphocyte negative for CD3 antigen and positive for CD16 antigen", "d": [], "t": []}, {"i": "SNOMEDCT:117527001", "l": "", "d": [], "t": []}], "preferred_name": "Lymphocyte negative for CD3 antigen and positive for CD16 antigen", "taxa": []}
{"type": "biolink:Cell", "ic": 86.30756602822301, "identifiers": [{"i": "UMLS:C1518310", "l": "Neutrophil with Pseudo Pelger-Huet Nucleus", "d": [], "t": []}, {"i": "NCIT:C36724", "l": "Neutrophil with Pseudo Pelger-Huet Nucleus", "d": [], "t": []}], "preferred_name": "Neutrophil with Pseudo Pelger-Huet Nucleus", "taxa": []}
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{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5853611", "l": "ASP-7317", "d": [], "t": []}], "preferred_name": "ASP-7317", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5986171", "l": "HEMO-CAR-T", "d": [], "t": []}], "preferred_name": "HEMO-CAR-T", "taxa": []}
{"type": "biolink:Cell", "ic": 92.76600187037766, "identifiers": [{"i": "CL:0000674", "l": "interfollicle cell", "d": ["A follicle cell that is part of the stalk connecting adjacent egg chambers."], "t": []}], "preferred_name": "interfollicle cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5666998", "l": "Liver Cancer Neoantigens-sensitized Autoimmune Cells IPM001", "d": [], "t": []}, {"i": "NCIT:C185431", "l": "Liver Cancer Neoantigens-sensitized Autoimmune Cells IPM001", "d": ["A preparation of autoimmune cells that have been sensitized to liver cancer neoantigens, with potential immunostimulating and antineoplastic activities, Upon administration of the liver cancer neoantigens-sensitized autoimmune cells IPM001, these cells may eradicate the liver cancer cells."], "t": []}], "preferred_name": "Liver Cancer Neoantigens-sensitized Autoimmune Cells IPM001", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0882791", "l": "Cell positive for CD13 antigen", "d": [], "t": []}, {"i": "SNOMEDCT:116751002", "l": "", "d": [], "t": []}], "preferred_name": "Cell positive for CD13 antigen", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0041362", "l": "Tumor Cells, Cultured", "d": [], "t": []}, {"i": "MESH:D014407", "l": "Tumor Cells, Cultured", "d": [], "t": []}], "preferred_name": "Tumor Cells, Cultured", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C3652635", "l": "technetium (99mTc) stannous agent labelled cells", "d": [], "t": []}], "preferred_name": "technetium (99mTc) stannous agent labelled cells", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C4330828", "l": "Non-Fucosylated Umbilical Cord Blood Regulatory T-cells", "d": [], "t": []}, {"i": "NCIT:C131536", "l": "Non-Fucosylated Umbilical Cord Blood Regulatory T-cells", "d": ["A preparation of non-fucosylated regulatory T-lymphocytes (Tregs) allogeneically derived from umbilical cord blood (UCB), with potential immunomodulating activity. Tregs are essential in maintaining immunologic homeostasis, preventing autoimmunity, through the suppression of self-reactive T-cells, and they may induce tolerance to allogeneic organ transplants, including hematopoetic stem cell transplants (HSCTs). Administration of the non-fucosylated UCB Tregs upon HSCT may prevent or reduce graft-versus host disease (GVHD)."], "t": []}], "preferred_name": "Non-Fucosylated Umbilical Cord Blood Regulatory T-cells", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "CL:0002408", "l": "immature Vgamma2-negative thymocyte", "d": ["A double negative post-natal thymocyte that has a T cell receptor consisting of a gamma chain that does not contain a Vgamma2 segment, and a delta chain. This cell type is CD4-negative, CD8-negative and CD24-positive."], "t": []}], "preferred_name": "immature Vgamma2-negative thymocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 78.80476858236055, "identifiers": [{"i": "UMLS:C5856641", "l": "Anti-CD20 CAR T Cells Preparation", "d": [], "t": []}, {"i": "NCIT:C201174", "l": "Anti-CD20 CAR T Cells Preparation", "d": ["Any preparation of chimeric antigen receptor (CAR) expressing T-lymphocytes that targets the tumor-associated antigen (TAA) CD20."], "t": []}], "preferred_name": "Anti-CD20 CAR T Cells Preparation", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C2337177", "l": "Mesothelial cell of parietal pleura", "d": [], "t": []}], "preferred_name": "Mesothelial cell of parietal pleura", "taxa": []}
{"type": "biolink:Cell", "ic": 83.11065783093733, "identifiers": [{"i": "UMLS:C1514111", "l": "Neoplastic T-Lymphocyte with Clear Cytoplasm", "d": [], "t": []}, {"i": "NCIT:C39657", "l": "Neoplastic T-Lymphocyte with Clear Cytoplasm", "d": [], "t": []}], "preferred_name": "Neoplastic T-Lymphocyte with Clear Cytoplasm", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4288077", "l": "omidubicel", "d": [], "t": []}], "preferred_name": "omidubicel", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:1000452", "l": "parietal epithelial cell", "d": ["An epithelial cell that is part of the glomerular parietal epithelium."], "t": []}, {"i": "UMLS:C1182790", "l": "Epithelial cell of parietal layer of glomerular capsule", "d": [], "t": []}], "preferred_name": "parietal epithelial cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5908021", "l": "Allogeneic CRISPR-edited Anti-CLL-1 CAR-T Cells CB-012", "d": [], "t": []}, {"i": "NCIT:C204039", "l": "Allogeneic CRISPR-edited Anti-CLL-1 CAR-T Cells CB-012", "d": ["A preparation of allogeneic, off-the-shelf T-lymphocytes genetically modified and clustered regularly interspaced short palindromic repeats (CRISPR)-edited to contain the deletion of the TRAC gene, the site-specific insertion of a chimeric antigen receptor (CAR) specific for the tumor-associated antigen (TAA) C-type-lectin-like molecule-1 (CLL-1; CLL1; C-type lectin domain family 12 member A; CLEC12A; CD371) into the TRAC gene, the knockout of programmed death 1 (PD-1; PDCD1; CD279; programmed cell death-1), the deletion of the B2M gene, and the site-specific insertion of a gene encoding a B2M-HLA-E-peptide fusion into the B2M gene, with potential immunostimulating and antineoplastic activities. Upon administration, allogeneic CRISPR-edited anti-CLL-1 CAR-T cells CB-012 recognize and bind to CLL-1-expressing tumor cells. This may result in a specific cytotoxic T-lymphocyte (CTL)-mediated killing of CLL-1-expressing tumor cells. Knock out of the TRAC gene eliminates the endogenous T-cell receptors (TCRs), thereby preventing graft-versus-host disease (GvHD). PD-1, an immune checkpoint receptor expressed on T-cells, plays a key role in tumor immune evasion by binding to its ligand programmed death ligand 1 (PD-L1; cluster of differentiation 274; CD274; programmed cell death-1 ligand 1) expressed on tumor cells. By removing PD-1 from T-cells, PD-1-mediated signaling is halted which may decrease T-cell exhaustion and may enhance T-cell activity against the CLL-1-expressing tumor cells. The B2M protein is removed to eliminate endogenous HLA class I expression on the surface of the CB-012 CAR-T cells, which protects the CAR-T cells from host T-cell rejection. The B2M-HLA-E fusion protein is inserted to protect the CAR-T cells from host natural killer (NK) cell rejection. CLL-1, a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily, is overexpressed in leukemic stem cells (LSCs) and plays an important role in disease progression and relapse for myeloid malignancies."], "t": []}], "preferred_name": "Allogeneic CRISPR-edited Anti-CLL-1 CAR-T Cells CB-012", "taxa": []}
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{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C3494245", "l": "Sf9 Cells", "d": [], "t": []}, {"i": "MESH:D061987", "l": "Sf9 Cells", "d": [], "t": []}], "preferred_name": "Sf9 Cells", "taxa": []}
{"type": "biolink:Cell", "ic": 78.54651317367835, "identifiers": [{"i": "CL:0000502", "l": "type D enteroendocrine cell", "d": ["A cell found throughout the gastrointestinal tract and in the pancreas. They secrete somatostatin in both an endocrine and paracrine manner. Somatostatin inhibits gastrin, cholecystokinin, insulin, glucagon, pancreatic enzymes, and gastric hydrochloric acid. A variety of substances which inhibit gastric acid secretion (vasoactive intestinal peptide, calcitonin gene-related peptide, cholecystokinin, beta-adrenergic agonists, and gastric inhibitory peptide) are thought to act by releasing somatostatin."], "t": []}, {"i": "UMLS:C2327166", "l": "Type D enteroendocrine cell", "d": [], "t": []}], "preferred_name": "type D enteroendocrine cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0002538", "l": "intrahepatic cholangiocyte", "d": ["An epithelial cell of the intrahepatic portion of the bile duct. These cells are flattened or cuboidal in shape, and have a small nuclear-to-cytoplasmic ratio relative to large/extrahepatic cholangiocytes."], "t": []}], "preferred_name": "intrahepatic cholangiocyte", "taxa": []}
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{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0440740", "l": "Granulocyte-specific", "d": [], "t": []}, {"i": "SNOMEDCT:256910006", "l": "", "d": [], "t": []}], "preferred_name": "Granulocyte-specific", "taxa": []}
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{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "UMLS:C1512945", "l": "Intraepithelial T-Lymphocyte of the Intestine", "d": [], "t": []}, {"i": "NCIT:C39613", "l": "Intraepithelial T-Lymphocyte of the Intestine", "d": ["A mature T lymphocyte, found in the intestinal lining that differentiates from its precursor outside the thymus, most likely in an area of the gut identified as cryptopatch aggregates. This cell plays a key role in cell-mediated mucosal defense, the down-regulation of immune responses to harmless luminal antigens and in epithelial cell growth and repair."], "t": []}], "preferred_name": "Intraepithelial T-Lymphocyte of the Intestine", "taxa": []}
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{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0002602", "l": "annulus pulposus cell", "d": ["Any connective tissue cell that is part of some annulus fibrosus disci intervertebralis."], "t": []}], "preferred_name": "annulus pulposus cell", "taxa": []}
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{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5163732", "l": "Erythrocytes | XXX | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Erythrocytes | XXX | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5157466", "l": "CD3+HLA-DR+ cells | Body fluid | Cell markers", "d": [], "t": []}], "preferred_name": "CD3+HLA-DR+ cells | Body fluid | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": 88.20185721311867, "identifiers": [{"i": "CL:0002404", "l": "fetal thymocyte", "d": ["A thymocyte found in the fetal thymus."], "t": []}], "preferred_name": "fetal thymocyte", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5426962", "l": "Erythrocytes | Lower respiratory specimen | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Erythrocytes | Lower respiratory specimen | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5970784", "l": "Ryoncil", "d": [], "t": []}], "preferred_name": "Ryoncil", "taxa": []}
{"type": "biolink:Cell", "ic": 86.30756602822301, "identifiers": [{"i": "CL:2000043", "l": "brain pericyte", "d": ["Any pericyte cell that is part of a brain."], "t": []}], "preferred_name": "brain pericyte", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4322825", "l": "CD8+CD57+ T Lymphocyte", "d": [], "t": []}], "preferred_name": "CD8+CD57+ T Lymphocyte", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0483188", "l": "CD22+CD19+", "d": [], "t": []}], "preferred_name": "CD22+CD19+", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5187678", "l": "HUMAN CORD BLOOD HEMATOPOIETIC PROGENITOR CELL 500000000 in 25 mL INTRAVENOUS INJECTION", "d": [], "t": []}], "preferred_name": "HUMAN CORD BLOOD HEMATOPOIETIC PROGENITOR CELL 500000000 in 25 mL INTRAVENOUS INJECTION", "taxa": []}
{"type": "biolink:Cell", "ic": 89.40238429118027, "identifiers": [{"i": "CL:1000892", "l": "kidney capillary endothelial cell", "d": ["An endothelial cell that is part of the capillary of the kidney."], "t": []}], "preferred_name": "kidney capillary endothelial cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C2331959", "l": "Set of cholinergic cells of amygdaloid body [Ch4]", "d": [], "t": []}], "preferred_name": "Set of cholinergic cells of amygdaloid body [Ch4]", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5157536", "l": "CD4+ CD26- Cells | Blood | Cell markers", "d": [], "t": []}], "preferred_name": "CD4+ CD26- Cells | Blood | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": 87.18682603146104, "identifiers": [{"i": "CL:2000084", "l": "conjunctiva goblet cell", "d": ["A goblet cell that is part of the conjunctival epithelium, characterized by apical accumulation of mucin granules (containing MUC5AC in humans; Muc5ac/Muc5b in mice). These gel-forming mucins support tear film stability, ocular lubrication, and pathogen defence. The conjunctival goblet cell forms tight junctions with neighbouring epithelial cells via species-specific claudins (claudin-10 in humans, claudin-2 in mice) and regulates immune homeostasis by facilitating soluble antigen transport to dendritic cells through goblet cell-associated antigen passages (GAPs) (Barbosa et al., 2017). The transcription factor SPDEF is essential for its differentiation."], "t": []}], "preferred_name": "conjunctiva goblet cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4740203", "l": "CD24-FLAER- cell", "d": [], "t": []}, {"i": "SNOMEDCT:1381846003", "l": "", "d": [], "t": []}], "preferred_name": "CD24-FLAER- cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5557204", "l": "Autologous Anti-CD4 CAR T-cells LB1901", "d": [], "t": []}, {"i": "NCIT:C181700", "l": "Autologous Anti-CD4 CAR T-cells LB1901", "d": ["A preparation of autologous T-lymphocytes that have been genetically modified and transduced with a lentiviral vector expressing a chimeric antigen receptor (CAR) targeting the tumor-associated antigen (TAA) CD4, with potential immunostimulating and antineoplastic activities. Upon administration, autologous anti-CD4 CAR T-cells LB1901 target and bind to CD4-expressing tumor cells, thereby inducing selective toxicity in CD4-expressing tumor cells. CD4 antigen is expressed in CD4-positive T-cell lymphomas."], "t": []}], "preferred_name": "Autologous Anti-CD4 CAR T-cells LB1901", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5157384", "l": "CD20+FMC7+ cells | Bone marrow | Cell markers", "d": [], "t": []}], "preferred_name": "CD20+FMC7+ cells | Bone marrow | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C2336931", "l": "Goblet cell of epithelium proper of large intestine", "d": [], "t": []}], "preferred_name": "Goblet cell of epithelium proper of large intestine", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5166243", "l": "Hairy cells | Blood | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Hairy cells | Blood | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0020060", "l": "basal duct cell of salivary gland", "d": ["A basal cell that is part of the duct of a salivary gland, characterized by an undifferentiated phenotype, expression of KRT5, and a position surrounding the striated ductal epithelium. This cell is presumed to function as a salivary gland stem/progenitor cell capable of regenerating ductal and potentially acinar cell populations (Yura and Hamada, 2023). In mice, Lgr5-expressing cells within this compartment demonstrate tripotent capacity, able to generate acinar, ductal, and myoepithelial cell lineages."], "t": []}], "preferred_name": "basal duct cell of salivary gland", "taxa": []}
{"type": "biolink:Cell", "ic": 89.40238429118027, "identifiers": [{"i": "UMLS:C0225368", "l": "Chondroblasts", "d": [], "t": []}, {"i": "NCIT:C32306", "l": "Chondroblast", "d": ["A cartilage-forming cell derived from a mesenchymal cell. The chondroblast secretes hyaluronidase, chondroitin sulfates, and collagen II to form a collagen matrix. It differentiates into a chondrocyte."], "t": []}, {"i": "SNOMEDCT:17512002", "l": "", "d": [], "t": []}], "preferred_name": "Chondroblasts", "taxa": []}
{"type": "biolink:Cell", "ic": 92.76600187037766, "identifiers": [{"i": "CL:0000968", "l": "Be cell", "d": ["A mature B cell that produces cytokines that can influence CD4 T cell differentiation."], "t": []}], "preferred_name": "Be cell", "taxa": []}
{"type": "biolink:Cell", "ic": 84.83823963392128, "identifiers": [{"i": "CL:0011004", "l": "lens fiber cell", "d": ["A vetebrate lens cell that is any of the elongated, tightly packed cells that make up the bulk of the mature lens in a camera-type eye."], "t": []}], "preferred_name": "lens fiber cell", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "UMLS:C1709163", "l": "Neoplastic Adrenal Cortical Oncocyte", "d": [], "t": []}, {"i": "NCIT:C48448", "l": "Neoplastic Adrenal Cortical Oncocyte", "d": [], "t": []}], "preferred_name": "Neoplastic Adrenal Cortical Oncocyte", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0333823", "l": "Smudge cell", "d": [], "t": []}, {"i": "SNOMEDCT:34717007", "l": "", "d": [], "t": []}], "preferred_name": "Smudge cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5446599", "l": "Autologous CD19 CAR-expressing T-cells YTB323", "d": [], "t": []}], "preferred_name": "Autologous CD19 CAR-expressing T-cells YTB323", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1513715", "l": "Mucinous Bronchial Cell", "d": [], "t": []}, {"i": "NCIT:C33922", "l": "Mucinous Bronchial Cell", "d": ["A columnar epithelial cell found in the bronchi. It secretes mucus."], "t": []}], "preferred_name": "Mucinous Bronchial Cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1267912", "l": "Lymphocyte positive for CD35 antigen", "d": [], "t": []}, {"i": "SNOMEDCT:117035005", "l": "", "d": [], "t": []}], "preferred_name": "Lymphocyte positive for CD35 antigen", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "CL:0020057", "l": "cholinergic neuron of myenteric plexus", "d": ["An enteric neuron whose soma resides in the myenteric plexus and which is capable of acetylcholine secretion, neurotransmission. This is a defined grouping class that autoclassifies stubby Dogiel type I neurons, intrinsic primary afferent neurons, ascending interneurons, and their morphological/chemical subterms."], "t": []}], "preferred_name": "cholinergic neuron of myenteric plexus", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4510911", "l": "Blast cell positive for CD33 antigen", "d": [], "t": []}, {"i": "SNOMEDCT:725171003", "l": "", "d": [], "t": []}], "preferred_name": "Blast cell positive for CD33 antigen", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0017473", "l": "Germ Line", "d": [], "t": []}], "preferred_name": "Germ Line", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4030008", "l": "pronephric podocyte", "d": ["A specialized epithelial cell that contains \"feet\" that interdigitate with the \"feet\" of other glomerular epithelial cells in the pronephros."], "t": []}], "preferred_name": "pronephric podocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 73.98236851641934, "identifiers": [{"i": "UMLS:C1708920", "l": "Malignant Syncytiotrophoblastic Giant Cell", "d": [], "t": []}, {"i": "NCIT:C54119", "l": "Malignant Syncytiotrophoblastic Giant Cell", "d": [], "t": []}], "preferred_name": "Malignant Syncytiotrophoblastic Giant Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 60.88593931175523, "identifiers": [{"i": "CL:0000839", "l": "myeloid lineage restricted progenitor cell", "d": ["A progenitor cell restricted to the myeloid lineage."], "t": []}], "preferred_name": "myeloid lineage restricted progenitor cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4033102", "l": "superior cervical ganglion TH neuron", "d": ["A sympathetic neuron that has the soma located in the superior cervical ganglion and expresses the marker tyrosine hydroxylase (TH)."], "t": []}], "preferred_name": "superior cervical ganglion TH neuron", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5157496", "l": "CD34 cells | XXX | Cell markers", "d": [], "t": []}], "preferred_name": "CD34 cells | XXX | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0002464", "l": "SIRPa-negative adipose dendritic cell", "d": ["An adipose dendritic cell that is SIRPa-negative."], "t": []}], "preferred_name": "SIRPa-negative adipose dendritic cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5157307", "l": "CD14 blasts | Blood | Cell markers", "d": [], "t": []}], "preferred_name": "CD14 blasts | Blood | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1179672", "l": "Stem cell of intestinal crypt of Lieberkuhn", "d": [], "t": []}], "preferred_name": "Stem cell of intestinal crypt of Lieberkuhn", "taxa": []}
{"type": "biolink:Cell", "ic": 75.70995031940328, "identifiers": [{"i": "UMLS:C1514086", "l": "Neoplastic Small Cleaved Follicle Center Cell", "d": [], "t": []}, {"i": "NCIT:C37002", "l": "Neoplastic Small Cleaved Follicle Center Cell", "d": [], "t": []}], "preferred_name": "Neoplastic Small Cleaved Follicle Center Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 54.050773250047456, "identifiers": [{"i": "CL:0000037", "l": "hematopoietic stem cell", "d": ["A stem cell from which all cells of the lymphoid and myeloid lineages develop, including blood cells and cells of the immune system. Hematopoietic stem cells lack cell markers of effector cells (lin-negative). Lin-negative is defined by lacking one or more of the following cell surface markers: CD2, CD3 epsilon, CD4, CD5 ,CD8 alpha chain, CD11b, CD14, CD19, CD20, CD56, ly6G, ter119."], "t": []}], "preferred_name": "hematopoietic stem cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5157370", "l": "CD2 cells | Bone marrow | Cell markers", "d": [], "t": []}], "preferred_name": "CD2 cells | Bone marrow | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0427890", "l": "Urinary epithelial cell", "d": [], "t": []}, {"i": "SNOMEDCT:250442001", "l": "", "d": [], "t": []}], "preferred_name": "Urinary epithelial cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5856200", "l": "Anti-TROP2-CAR-IL-15-transduced Cord Blood-derived Natural Killer Cells", "d": [], "t": []}, {"i": "NCIT:C200344", "l": "Anti-TROP2-CAR-IL-15-transduced Cord Blood-derived Natural Killer Cells", "d": ["A preparation of umbilical cord blood (CB)-derived natural killer cells (NKs) that have been engineered to express a chimeric antigen receptor (CAR) specific for the tumor-associated antigen (TAA) trophoblast cell surface protein 2 (trophoblast antigen 2; tumor-associated calcium signal transducer 2; TROP2; TROP-2; TACSTD2; GA733-1; M1S1) and interleukin-15 (IL-15), with potential immunostimulating and antineoplastic activities. Upon administration, anti-TROP2-CAR-IL-15-transduced CB-derived NK cells target, bind to and induce selective cytotoxicity in TROP2-expressing tumor cells. IL-15 is a pro-survival cytokine that promotes persistence of multiple lymphocyte lineages and potentiates the immune response against tumor cells. TROP2 is a transmembrane protein overexpressed in various tumors. Its expression is associated with enhanced tumor aggressiveness, metastasis, drug resistance and increased tumor cell survival."], "t": []}], "preferred_name": "Anti-TROP2-CAR-IL-15-transduced Cord Blood-derived Natural Killer Cells", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0002652", "l": "endothelial cell of high endothelial venule", "d": ["A venule endothelial cell that is cubodial, expresses leukocyte-specific receptors, and allows for passage of lymphocytes into bloodstream."], "t": []}, {"i": "UMLS:C1180240", "l": "Endothelial cell of postcapillary venule of lymph node", "d": [], "t": []}], "preferred_name": "endothelial cell of high endothelial venule", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0333860", "l": "ABNORMAL MEGAKARYOCYTES AND PLATELETS", "d": [], "t": []}], "preferred_name": "ABNORMAL MEGAKARYOCYTES AND PLATELETS", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1709180", "l": "Neoplastic Immunoblast-Like T-Lymphocyte", "d": [], "t": []}, {"i": "NCIT:C45331", "l": "Neoplastic Immunoblast-Like T-Lymphocyte", "d": [], "t": []}], "preferred_name": "Neoplastic Immunoblast-Like T-Lymphocyte", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4528709", "l": "MAGE-A4C1032T", "d": [], "t": []}], "preferred_name": "MAGE-A4C1032T", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "CL:0008032", "l": "rosehip neuron", "d": ["A GABAergic interneuron in human cortical layer 1 that has large rosehip-shaped axonal boutons and compact arborization."], "t": []}], "preferred_name": "rosehip neuron", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5168983", "l": "Immature reticulocytes | Blood | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Immature reticulocytes | Blood | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5216201", "l": "Eosinophils|NCnc|Pt|CSF", "d": [], "t": []}], "preferred_name": "Eosinophils|NCnc|Pt|CSF", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5670962", "l": "Partially HLA-matched Multiple TAA-specific Allogeneic T-lymphocytes", "d": [], "t": []}, {"i": "NCIT:C187028", "l": "Partially HLA-matched Multiple TAA-specific Allogeneic T-lymphocytes", "d": ["A preparation of partially human leukocyte antigen (HLA)-matched allogeneic T-lymphocytes targeting multiple tumor-associated antigens (TAAs), with potential immunomodulating and antineoplastic activities. Upon administration, partially HLA-matched multiple TAA-specific allogeneic T-lymphocytes target and kill tumor cells expressing these TAAs."], "t": []}], "preferred_name": "Partially HLA-matched Multiple TAA-specific Allogeneic T-lymphocytes", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4028003", "l": "alveolar capillary type 2 endothelial cell", "d": ["An alveolar capillary endothelial cell that is located proximally to alveolar capillary type 1 endothelial cells and in close apposition to alveolar type 1 epithelial cells (also known as type I pneumocytes)."], "t": []}], "preferred_name": "alveolar capillary type 2 endothelial cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5161838", "l": "Dacrocytes | Blood | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Dacrocytes | Blood | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1511434", "l": "CEA RNA-pulsed Autologous Human Cultured Dendritic Cells", "d": [], "t": []}, {"i": "NCIT:C2710", "l": "CEA RNA-pulsed Autologous Human Cultured Dendritic Cells", "d": ["Autologous human dendritic cells pulsed with RNA encoding the carcinoembryonic antigen (CEA) are being studied for possible use in the treatment of cancer expressing CEA."], "t": []}], "preferred_name": "CEA RNA-pulsed Autologous Human Cultured Dendritic Cells", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4042027", "l": "GABAergic interneuron of the posterior substantia nigra pars reticulata", "d": ["A GABAergic interneuron that has its soma in the posterior section of the substantia nigra pars reticulata. This GABAergic interneuron is characterised by the expression of the transcription factors Pax5, Ctip2 and Pou6f2 and it develops from the ventrolateral r1 neuroepithelium expresing NKX61."], "t": []}], "preferred_name": "GABAergic interneuron of the posterior substantia nigra pars reticulata", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5761785", "l": "TVI-Brain-1", "d": [], "t": []}, {"i": "NCIT:C199632", "l": "Autologous Vaccine-enhanced Ex Vivo Activated Cancer Neoantigens-specific T-cells TVI-Brain-1", "d": ["A preparation of autologous T-lymphocytes collected from the patient after the administration of a personalized cancer vaccine composed of an attenuated form of patient-specific cancer cells and an immunological adjuvant, via leukapheresis, and activated ex vivo, with potential immunostimulating and antineoplastic activities. Cancer neoantigens-specific T-cells are collected after the administration of the personalized cancer vaccine and expanded ex vivo. Upon administration, the autologous vaccine-enhanced ex vivo activated cancer neoantigens-specific T-cells TVI-Brain-1 recognize and bind to tumor cells expressing the cancer neoantigens, resulting in a cytotoxic T-lymphocyte (CTL)-mediated immune response against the patient's tumor cells."], "t": []}], "preferred_name": "TVI-Brain-1", "taxa": []}
{"type": "biolink:Cell", "ic": 81.34422831136257, "identifiers": [{"i": "UMLS:C1883703", "l": "Large Melanoma Cell", "d": [], "t": []}, {"i": "NCIT:C62400", "l": "Large Melanoma Cell", "d": [], "t": []}], "preferred_name": "Large Melanoma Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 92.76600187037766, "identifiers": [{"i": "CL:1000347", "l": "colonocyte", "d": ["An enterocyte (absorptive epithelial cell) of the colonic epithelium, characterized by a columnar shape. This cell is responsible for the absorption, transport, and metabolization of short-chain fatty acids (SCFAs) produced by gut bacteria, as well as the transport and absorption of water and electrolytes."], "t": []}, {"i": "UMLS:C2322820", "l": "Vacuolar absorptive cell of epithelium of colon", "d": [], "t": []}], "preferred_name": "colonocyte", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C6064627", "l": "PD-L1+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:1373085007", "l": "", "d": [], "t": []}], "preferred_name": "PD-L1+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5161795", "l": "Cytoplasmic CD179a blasts | Blood | Cell markers", "d": [], "t": []}], "preferred_name": "Cytoplasmic CD179a blasts | Blood | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5157471", "l": "CD3+IL2R1+ cells | Blood | Cell markers", "d": [], "t": []}], "preferred_name": "CD3+IL2R1+ cells | Blood | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "UMLS:C1512085", "l": "Ductal Epithelial Cell", "d": [], "t": []}, {"i": "NCIT:C12479", "l": "Ductal Epithelial Cell", "d": ["A stratified columnar epithelial cell that surrounds a lumen in a gland such as the breast, pancreas or prostate. These cells are uniform in appearance and have uniformly sized and shaped nuclei."], "t": []}], "preferred_name": "Ductal Epithelial Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "CL:2000035", "l": "anterior lateral line neuromast mantle cell", "d": ["Any neuromast mantle cell that is part of an anterior lateral line."], "t": []}], "preferred_name": "anterior lateral line neuromast mantle cell", "taxa": []}
{"type": "biolink:Cell", "ic": 87.18682603146104, "identifiers": [{"i": "CL:0000961", "l": "Bm1 B cell", "d": ["A follicular B cell that is IgD-positive, CD23-negative, and CD38-negative. This naive cell type is activated in the extrafollicular areas through interaction with interdigitating dendritic cells and antigen-specific CD4-positive T cells."], "t": []}], "preferred_name": "Bm1 B cell", "taxa": []}
{"type": "biolink:Cell", "ic": 83.11065783093733, "identifiers": [{"i": "UMLS:C1514177", "l": "Pleomorphic Plasma Cell", "d": [], "t": []}, {"i": "NCIT:C37083", "l": "Pleomorphic Plasma Cell", "d": [], "t": []}], "preferred_name": "Pleomorphic Plasma Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 90.871710685482, "identifiers": [{"i": "CL:0007002", "l": "precementoblast", "d": ["Skeletogenic cell that has the potential to develop into a cementoblast."], "t": []}], "preferred_name": "precementoblast", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C2347368", "l": "Nucleated blood cell", "d": [], "t": []}, {"i": "NCIT:C73126", "l": "Nucleated Blood Cell", "d": ["The cellular material of blood consisting of white blood cells and nucleated red blood cells."], "t": []}, {"i": "SNOMEDCT:645131010000105", "l": "", "d": [], "t": []}], "preferred_name": "Nucleated blood cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1440056", "l": "Abnormal blood cells.CD7", "d": [], "t": []}], "preferred_name": "Abnormal blood cells.CD7", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C4085963", "l": "Anti-CD22 scFv TCRz:41BB-CAR Lentiviral Vector-transduced Autologous T-lymphocytes", "d": [], "t": []}, {"i": "NCIT:C124656", "l": "Anti-CD22 scFv TCRz:41BB-CAR Lentiviral Vector-transduced Autologous T-lymphocytes", "d": ["Autologous human T-lymphocytes transduced with a recombinant lentiviral vector encoding a chimeric T-cell receptor consisting of an anti-CD22 single chain variable fragment (scFv) and the co-stimulatory domain 4-1BB (CD137) coupled to the zeta chain of the TCR/CD3 complex (CD3-zeta), with potential immunostimulating and antineoplastic activities. Autologous peripheral blood lymphocytes (PBLs) from a patient with CD22-positive cancer are transduced with this lentiviral vector that encodes the CAR gene specific for CD22. After isolation, transduction, expansion in culture and reintroduction into the patient, the anti-CD22 scFv TCRz:41BB-CAR lentiviral vector-transduced autologous T-lymphocytes express anti-CD22-CAR on their cell surfaces and bind to the CD22 antigen on tumor cell surfaces. Subsequently, CD22-expressing tumor cells are lysed. CD22, a B-lineage-restricted, transmembrane phosphoglycoprotein, is expressed on malignant B-cells."], "t": []}], "preferred_name": "Anti-CD22 scFv TCRz:41BB-CAR Lentiviral Vector-transduced Autologous T-lymphocytes", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5554940", "l": "Autologous Spermatogonial Stem Cells", "d": [], "t": []}, {"i": "NCIT:C178314", "l": "Autologous Spermatogonial Stem Cells", "d": ["A preparation of autologous spermatogonial stem cells (SSCs), that can potentially be used for intratesticular transplantation purposes. Upon injection into the testis, the autologous SCCs may recolonize and induce spermatogenesis, leading to mature spermatozoa, and thereby restoring fertility."], "t": []}], "preferred_name": "Autologous Spermatogonial Stem Cells", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1525453", "l": "CD19+CD33+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:1372980005", "l": "", "d": [], "t": []}], "preferred_name": "CD19+CD33+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": 59.458332183916376, "identifiers": [{"i": "CL:0007009", "l": "prechondroblast", "d": ["Skeletogenic cell that has the potential to develop into a chondroblast; and arises from neural crest, meseosdermal and notochordal and connective tissue cells."], "t": []}], "preferred_name": "prechondroblast", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1267972", "l": "Lymphocyte positive for CD80 antigen", "d": [], "t": []}, {"i": "SNOMEDCT:117412004", "l": "", "d": [], "t": []}], "preferred_name": "Lymphocyte positive for CD80 antigen", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5690737", "l": "M Cells, Intestinal", "d": [], "t": []}], "preferred_name": "M Cells, Intestinal", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0002182", "l": "obsolete surface mucosal cell of stomach", "d": ["OBSOLETE. A simple columnar cell that populates the entire luminal surface including the gastric pits. This cell types secrete mucus to form a thick protective, lubricant layer over the gastric wall."], "t": []}, {"i": "UMLS:C1179471", "l": "Surface mucous cell of stomach", "d": [], "t": []}], "preferred_name": "obsolete surface mucosal cell of stomach", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4733830", "l": "Fibroblasts (Human)", "d": [], "t": []}], "preferred_name": "Fibroblasts (Human)", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C3831512", "l": "Anti-NY-ESO1 TCR-transduced Autologous CD62L+-derived T-Lymphocytes", "d": [], "t": []}, {"i": "NCIT:C114295", "l": "Anti-NY-ESO1 TCR-transduced Autologous CD62L+-derived T-Lymphocytes", "d": ["Human autologous CD62L-positive T-lymphocytes transduced with a retroviral vector encoding a T cell receptor (TCR) specific for the cancer-testis antigen NY-ESO-1, with potential antineoplastic activity. Following leukapheresis, isolation of lymphocytes, expansion ex vivo, transduction, and reintroduction into the patient, the anti-NY-ESO1 TCR-transduced autologous CD62L+-derived T-Lymphocytes bind to NY-ESO-1-overexpressing tumor cells. This may result in cytotoxic T-lymphocyte (CTL)-mediated elimination of NY-ESO-1-positive cancer cells. NY-ESO-1, a tumor associated antigen (TAA), is found in normal testis and on the surface of various tumor cell types. CD62L, also called L-selectin, is a lymphoid homing receptor and differentiation marker and is expressed on a subset of CD8-positive T-lymphocytes; it is involved in the migration of T-lymphocytes to lymph nodes and may improve the efficacy for ex vivo-expanded T-cells following adoptive cell therapy."], "t": []}], "preferred_name": "Anti-NY-ESO1 TCR-transduced Autologous CD62L+-derived T-Lymphocytes", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1267893", "l": "Lymphocyte positive for both CD22 antigen and CD11C antigen", "d": [], "t": []}, {"i": "SNOMEDCT:117566009", "l": "", "d": [], "t": []}], "preferred_name": "Lymphocyte positive for both CD22 antigen and CD11C antigen", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1648295", "l": "CD13+CD56+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:1372969005", "l": "", "d": [], "t": []}], "preferred_name": "CD13+CD56+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": 87.18682603146104, "identifiers": [{"i": "CL:0002503", "l": "adventitial cell", "d": ["A cell of the adventitial layer of ductal structures such as the uterer, defent duct, biliary duct, etc"], "t": []}], "preferred_name": "adventitial cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1267820", "l": "Lymphocyte positive for both CD3 antigen and CD38 antigen", "d": [], "t": []}, {"i": "SNOMEDCT:117521000", "l": "", "d": [], "t": []}], "preferred_name": "Lymphocyte positive for both CD3 antigen and CD38 antigen", "taxa": []}
{"type": "biolink:Cell", "ic": 56.9294834328601, "identifiers": [{"i": "CL:0000203", "l": "gravity sensitive cell", "d": ["Any neuronal receptor cell that is capable of some detection of mechanical stimulus involved in sensory perception."], "t": []}], "preferred_name": "gravity sensitive cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0000986", "l": "IgM plasma cell", "d": ["A fully differentiated plasma cell that secretes IgM."], "t": []}], "preferred_name": "IgM plasma cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1113687", "l": "human embryonic stem cell line", "d": [], "t": []}], "preferred_name": "human embryonic stem cell line", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "CL:1000335", "l": "enterocyte of epithelium of intestinal villus", "d": ["An enterocyte that is part of the epithelium of intestinal villus."], "t": []}, {"i": "UMLS:C2333121", "l": "Enterocyte of epithelium of intestinal villus", "d": [], "t": []}], "preferred_name": "enterocyte of epithelium of intestinal villus", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0009103", "l": "lymph node marginal reticular cell", "d": ["A fibroblastic reticular cell found in the lymph node subcapsular sinus."], "t": []}], "preferred_name": "lymph node marginal reticular cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4246711", "l": "Vascular smooth muscle cell of left coronary artery", "d": [], "t": []}], "preferred_name": "Vascular smooth muscle cell of left coronary artery", "taxa": []}
{"type": "biolink:Cell", "ic": 92.76600187037766, "identifiers": [{"i": "UMLS:C1522667", "l": "Mouse Monocyte", "d": [], "t": []}, {"i": "NCIT:C22586", "l": "Mouse Monocyte", "d": [], "t": []}], "preferred_name": "Mouse Monocyte", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C2335377", "l": "Set of cholinergic cells of accumbens nucleus [Ch3]", "d": [], "t": []}], "preferred_name": "Set of cholinergic cells of accumbens nucleus [Ch3]", "taxa": []}
{"type": "biolink:Cell", "ic": 79.64650900338474, "identifiers": [{"i": "CL:1001516", "l": "intestinal enteroendocrine cell", "d": ["The various hormone- or neurotransmitter-secreting cells present throughout the mucosa of the intestinal tract."], "t": []}], "preferred_name": "intestinal enteroendocrine cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C4763629", "l": "Valproic Acid-Expanded Umbilical Cord Blood-derived CD34-positive Cells", "d": [], "t": []}, {"i": "NCIT:C157453", "l": "Valproic Acid-Expanded Umbilical Cord Blood-derived CD34-positive Cells", "d": ["A preparation of umbilical cord blood (UCB)-derived CD34-positive cells treated with valproic acid (VPA) with potential use in hematopoietic stem cell transplant (HSCT). Upon positive immunomagnetic selection of CD34-positive cells from UCB units, CD34-positive cells are expanded in culture with stem cell factor (SCF), FMS-like tyrosine kinase 3 ligand (Flt3L), thrombopoietin (TPO), and interleukin-3 (IL-3), treated with VPA, and infused into the patient. VPA, a histone deacetylase inhibitor (HDACi), may induce epigenetic changes in UCB hematopoietic stem cells (HSCs), resulting in expansion of CD34-positive cells enriched in short term (ST), intermediate term (IT), and long term (LT) marrow repopulating cells (RCs), which are capable of sustained hematopoietic engraftment following transplantation. Further, VPA-expanded UCB stem cells may shorten the time to neutrophil and platelet recovery and maintain long-term hematopoietic and immune reconstitution compared to untreated UCB grafts."], "t": []}], "preferred_name": "Valproic Acid-Expanded Umbilical Cord Blood-derived CD34-positive Cells", "taxa": []}
{"type": "biolink:Cell", "ic": 90.871710685482, "identifiers": [{"i": "CL:1001111", "l": "kidney loop of Henle thin descending limb epithelial cell", "d": ["An epithelial cell that is part of some loop of Henle thin descending limb."], "t": []}], "preferred_name": "kidney loop of Henle thin descending limb epithelial cell", "taxa": []}
{"type": "biolink:Cell", "ic": 88.20185721311867, "identifiers": [{"i": "UMLS:C0225698", "l": "Alveolar Epithelial Cells", "d": [], "t": []}, {"i": "NCIT:C32053", "l": "Alveolar Cell", "d": ["A cell found in the walls of the pulmonary alveoli; the term is limited to alveolar epithelial cells (type I and type II alveolar cells)."], "t": []}, {"i": "MESH:D056809", "l": "Alveolar Epithelial Cells", "d": [], "t": []}, {"i": "SNOMEDCT:47438009", "l": "", "d": [], "t": []}], "preferred_name": "Alveolar Epithelial Cells", "taxa": []}
{"type": "biolink:Cell", "ic": 60.385597276056416, "identifiers": [{"i": "UMLS:C1708915", "l": "Malignant Spindle Cell", "d": [], "t": []}, {"i": "NCIT:C53637", "l": "Malignant Spindle Cell", "d": [], "t": []}], "preferred_name": "Malignant Spindle Cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5216311", "l": "Granulocytes|NCnc|Pt|Periton fld", "d": [], "t": []}], "preferred_name": "Granulocytes|NCnc|Pt|Periton fld", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5216293", "l": "Neutrophils|NCnc|Pt|Pericard fld", "d": [], "t": []}], "preferred_name": "Neutrophils|NCnc|Pt|Pericard fld", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0002564", "l": "nucleus pulposus cell of intervertebral disc", "d": ["A connective tissue cell of the nucleus pulposus cell of intervertebral disc."], "t": []}], "preferred_name": "nucleus pulposus cell of intervertebral disc", "taxa": []}
{"type": "biolink:Cell", "ic": 49.83957571063885, "identifiers": [{"i": "CL:0000125", "l": "glial cell", "d": ["A non-neuronal cell of the nervous system. They not only provide physical support, but also respond to injury, regulate the ionic and chemical composition of the extracellular milieu. Guide neuronal migration during development, and exchange metabolites with neurons."], "t": []}], "preferred_name": "glial cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4301984", "l": "Non-motile spermatozoa", "d": [], "t": []}, {"i": "SNOMEDCT:723203005", "l": "", "d": [], "t": []}], "preferred_name": "Non-motile spermatozoa", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0225467", "l": "Middle cells of ethmoid sinus", "d": [], "t": []}], "preferred_name": "Middle cells of ethmoid sinus", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0600432", "l": "K562 Cells", "d": [], "t": []}, {"i": "MESH:D020014", "l": "K562 Cells", "d": [], "t": []}], "preferred_name": "K562 Cells", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0000732", "l": "amoeboid cell", "d": [], "t": []}], "preferred_name": "amoeboid cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5237454", "l": "ALLO-715", "d": [], "t": []}, {"i": "NCIT:C165779", "l": "Allogeneic Anti-BCMA CAR-transduced T-cells ALLO-715", "d": ["A preparation of allogeneic, 'off-the-shelf' (OTS), universal transcription activator-like effector nuclease (TALEN)-engineered, gene-edited T-lymphocytes that have been transduced with a vector expressing a chimeric antigen receptor (CAR) containing a single chain variable fragment (scFv) derived from a monoclonal antibody specific for the human tumor-associated antigen (TAA) B-cell maturation antigen (BCMA; tumor necrosis factor receptor superfamily member 17; TNFRSF17), with potential immunostimulating and antineoplastic activities. Using TALEN technology, the T-cell receptor (TCR) alpha chain (TRAC) and CD52 genes are deleted from the CAR T-cells. Upon administration, nendocabtagene onogedleucel specifically recognize and induce selective toxicity in BCMA-expressing tumor cells. BCMA, a receptor for both a proliferation-inducing ligand (APRIL) and B-cell activating factor (BAFF), is a member of the tumor necrosis factor receptor superfamily (TNFRSF). BCMA is found on the surfaces of plasma cells, is overexpressed on malignant plasma cells and plays a key role in plasma cell proliferation and survival. Deletion of the CD52 gene makes the modified donor T-cells resistant to an anti-CD52 monoclonal antibody treatment, that is used during lymphodepletion. The knockout of TRAC eliminates TCR expression and is intended to abrogate the potential induction of graft-versus-host disease (GvHD) by the donor T-cells. The donor-derived, gene-edited CAR T cells have reduced production times and have increased availability when compared to autologous CAR-T cells, which use the patient's own cells and are produced on an individual basis. In addition, if nendocabtagene onogedleucel cause unacceptable side effects, the incorporated CD20-based off-switch permits selective depletion of the ALLO-715 cells when the anti-CD20 monoclonal antibody rituximab is administered."], "t": []}], "preferred_name": "ALLO-715", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1267933", "l": "Lymphocyte positive for CD46 antigen", "d": [], "t": []}, {"i": "SNOMEDCT:117376006", "l": "", "d": [], "t": []}], "preferred_name": "Lymphocyte positive for CD46 antigen", "taxa": []}
{"type": "biolink:Cell", "ic": 57.867371168080936, "identifiers": [{"i": "CL:0000327", "l": "extracellular matrix secreting cell", "d": [], "t": []}], "preferred_name": "extracellular matrix secreting cell", "taxa": []}
{"type": "biolink:Cell", "ic": 76.40371442623734, "identifiers": [{"i": "CL:0001029", "l": "common dendritic progenitor", "d": ["Common dendritic precursor is a hematopoietic progenitor cell that is CD117-low, CD135-positive, CD115-positive and lacks plasma membrane parts for hematopoietic lineage markers."], "t": []}], "preferred_name": "common dendritic progenitor", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5575124", "l": "LCAR B38M", "d": [], "t": []}], "preferred_name": "LCAR B38M", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1515627", "l": "gp100-Reactive Autologous Tumor Infiltrating Lymphocyte", "d": [], "t": []}, {"i": "NCIT:C38125", "l": "gp100-Reactive Autologous Tumor Infiltrating Lymphocyte", "d": ["Tumor infiltrating lymphocytes (TIL) isolated from a patient, exposed to the tumor-associated antigen gp100 in vitro, and then transferred back to the same patient to target tumor cells expressing gp100. gp100 human antigen is a wild-type self-antigen expressed by melanocytes, pigmented retinal cells and most melanomas. (NCI04)"], "t": []}], "preferred_name": "gp100-Reactive Autologous Tumor Infiltrating Lymphocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 76.04769967783396, "identifiers": [{"i": "CL:0001032", "l": "cortical granule cell", "d": ["Granule cell that is part of the cerebral cortex."], "t": []}], "preferred_name": "cortical granule cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4032001", "l": "reelin GABAergic cortical interneuron", "d": ["A GABAergic interneuron located in the cerebral cortex that expresses reelin (rln)."], "t": []}], "preferred_name": "reelin GABAergic cortical interneuron", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C4733637", "l": "Autologous HPV-specific Cytotoxic T Lymphocytes", "d": [], "t": []}, {"i": "NCIT:C155880", "l": "Autologous HPV-specific Cytotoxic T Lymphocytes", "d": ["A population of autologous cytotoxic T-lymphocytes (CTLs) that are specifically reactive to human papillomavirus (HPV), with potential antiviral and antineoplastic activities activities. Upon infusion of the autologous HPV-specific CTLs, these CTLs induce selective toxicity in HPV-positive cancer cells and other HPV-infected cells. HPV is associated with various cancer cell types."], "t": []}], "preferred_name": "Autologous HPV-specific Cytotoxic T Lymphocytes", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C2335060", "l": "Intermediate trophoblast", "d": [], "t": []}, {"i": "MESH:D000097862", "l": "Extravillous Trophoblasts", "d": [], "t": []}], "preferred_name": "Intermediate trophoblast", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0682521", "l": "primate cell line", "d": [], "t": []}], "preferred_name": "primate cell line", "taxa": []}
{"type": "biolink:Cell", "ic": 74.11023018174025, "identifiers": [{"i": "CL:1001451", "l": "sensory neuron of dorsal root ganglion", "d": ["A sensory neuron of the dorsal root ganglia that senses body position and sends information about how much the muscle is stretched to the spinal cord."], "t": []}], "preferred_name": "sensory neuron of dorsal root ganglion", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:1000375", "l": "myocardial endocrine cell of septal division of left branch of atrioventricular bundle", "d": ["A myocardial endocrine cell that is part of the septal division of left branch of atrioventricular bundle."], "t": []}, {"i": "UMLS:C2335776", "l": "Myocardial endocrine cell of septal division of left branch of atrioventricular bundle", "d": [], "t": []}], "preferred_name": "myocardial endocrine cell of septal division of left branch of atrioventricular bundle", "taxa": []}
{"type": "biolink:Cell", "ic": 82.62268137420203, "identifiers": [{"i": "UMLS:C0432608", "l": "Ringed sideroblast", "d": [], "t": []}, {"i": "NCIT:C37058", "l": "Ring Sideroblast", "d": [], "t": []}, {"i": "SNOMEDCT:259679003", "l": "", "d": [], "t": []}], "preferred_name": "Ringed sideroblast", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1269647", "l": "Entire cell", "d": [], "t": []}, {"i": "SNOMEDCT:362837007", "l": "", "d": [], "t": []}], "preferred_name": "Entire cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C0598786", "l": "Ground Glass Hepatocyte", "d": [], "t": []}, {"i": "NCIT:C83011", "l": "Ground Glass Hepatocyte", "d": ["An abnormally large hepatocyte with eosinophilic or pale, glassy cytoplasm and peripherally displaced nucleus.  This appearance is due to hyperplasia of the smooth endoplasmic reticulum."], "t": []}], "preferred_name": "Ground Glass Hepatocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0000383", "l": "nephrogenic mesenchyme stem cell", "d": [], "t": []}], "preferred_name": "nephrogenic mesenchyme stem cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1517641", "l": "KA41 cell line", "d": [], "t": []}, {"i": "NCIT:C20271", "l": "KA41", "d": ["Provider: Karolinska Institute, Stockholm, Sweden. No information from provider. This cell line meets the criteria for the use of human embryonic stem cells by federally funded researchers."], "t": []}], "preferred_name": "KA41 cell line", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0483183", "l": "CD16-CD57-", "d": [], "t": []}], "preferred_name": "CD16-CD57-", "taxa": []}
{"type": "biolink:Cell", "ic": 79.9528279018387, "identifiers": [{"i": "UMLS:C1513487", "l": "Monovacuolated Lipoblast", "d": [], "t": []}, {"i": "NCIT:C36972", "l": "Monovacuolated Lipoblast", "d": [], "t": []}], "preferred_name": "Monovacuolated Lipoblast", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:1000717", "l": "kidney outer medulla collecting duct intercalated cell", "d": ["Intercalated cell that is part of some outer medullary collecting duct. It is known in some mammalian species that this cell may contribute in the maintenance of acid/base homeostasis."], "t": []}], "preferred_name": "kidney outer medulla collecting duct intercalated cell", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "UMLS:C1516901", "l": "Eosinophilic Meningothelial Cell", "d": [], "t": []}, {"i": "NCIT:C37159", "l": "Eosinophilic Meningothelial Cell", "d": [], "t": []}], "preferred_name": "Eosinophilic Meningothelial Cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0524455", "l": "Structure of exocervical epithelial cell", "d": [], "t": []}, {"i": "SNOMEDCT:91687006", "l": "", "d": [], "t": []}], "preferred_name": "Structure of exocervical epithelial cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5770492", "l": "SynKIR-110", "d": [], "t": []}, {"i": "NCIT:C192653", "l": "Autologous Anti-mesothelin KIR-CAR-transduced T-cells SynKIR-110", "d": ["A preparation of autologous T-lymphocytes that have been genetically modified to express a killer cell immunoglobulin-like receptor (KIR)-based chimeric antigen receptor (CAR) consisting of an anti-mesothelin (MSLN) single chain variable fragment (scFv) fused to the transmembrane and cytoplasmic domains of the stimulatory KIR 2DS2 (KIR2DS2), and the immunoreceptor tyrosine-based activation motif (ITAM)-containing adaptor protein and costimulatory chain DAP12, with potential immunomodulating and antineoplastic activities. Upon administration, the autologous anti-MSLN KIR-CAR-transduced T-cells SynKIR-110 specifically target and kill MSLN-expressing tumor cells. Mesothelin, a tumor-associated antigen (TAA) and cell surface glycoprotein involved in cell adhesion, is overexpressed in a variety of cancer cell types. KIR is normally expressed by natural killer (NK) cells, and KIR-based CAR may decrease T-cell exhaustion and enhance T-cell persistence."], "t": []}], "preferred_name": "SynKIR-110", "taxa": []}
{"type": "biolink:Cell", "ic": 78.54651317367835, "identifiers": [{"i": "CL:0000295", "l": "somatotropin secreting cell", "d": ["A peptide hormone secreting cell that produces growth hormone, somatotropin."], "t": []}], "preferred_name": "somatotropin secreting cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5401593", "l": "Adipose-Derived Mesenchymal Stem Cells: Autologous or Allogeneic Origins", "d": [], "t": []}], "preferred_name": "Adipose-Derived Mesenchymal Stem Cells: Autologous or Allogeneic Origins", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1514277", "l": "Postradiation Dysplastic Squamous Cell", "d": [], "t": []}, {"i": "NCIT:C36806", "l": "Postradiation Dysplastic Squamous Cell", "d": [], "t": []}], "preferred_name": "Postradiation Dysplastic Squamous Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 75.2337427109536, "identifiers": [{"i": "UMLS:C1514018", "l": "Neoplastic Medium-Sized T-Lymphocyte", "d": [], "t": []}, {"i": "NCIT:C39600", "l": "Neoplastic Medium-Sized T-Lymphocyte", "d": [], "t": []}], "preferred_name": "Neoplastic Medium-Sized T-Lymphocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0000033", "l": "apocrine cell", "d": ["An exocrine cell characterized by loss of part of the cytoplasm during the process of secretion. The secreted substance is accumulated at the apical end and is either budded off through the plasma membrane producing secreted vesicles or dissolved in the cytoplasm that is lost during secretion."], "t": []}], "preferred_name": "apocrine cell", "taxa": []}
{"type": "biolink:Cell", "ic": 82.62268137420203, "identifiers": [{"i": "UMLS:C1511177", "l": "Neoplastic Piloid Astrocyte", "d": [], "t": []}, {"i": "NCIT:C37138", "l": "Neoplastic Piloid Astrocyte", "d": [], "t": []}], "preferred_name": "Neoplastic Piloid Astrocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1518075", "l": "Lymphokine-activated natural killer cell", "d": [], "t": []}, {"i": "NCIT:C33041", "l": "Lymphokine-Activated Natural Killer Cell", "d": ["A natural killer cell, activated by a soluble cytokine released by a lymphocyte in response to an antigen. It is important in immune response."], "t": []}], "preferred_name": "Lymphokine-activated natural killer cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5382908", "l": "HLA-B8 CMV specific CD8 cells | Blood | Cell markers", "d": [], "t": []}], "preferred_name": "HLA-B8 CMV specific CD8 cells | Blood | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5854405", "l": "Autologous Tumor Infiltrating Lymphocytes C-TIL051", "d": [], "t": []}, {"i": "NCIT:C199290", "l": "Autologous Tumor Infiltrating Lymphocytes C-TIL051", "d": ["A preparation of autologous tumor infiltrating lymphocytes (TILs) derived from each patient's resected tumor and expanded ex vivo, with potential immunomodulating and antineoplastic activities. Upon administration back into the patient, the autologous TILs C-TIL051 specifically recognize and kill the patient's tumor cells."], "t": []}], "preferred_name": "Autologous Tumor Infiltrating Lymphocytes C-TIL051", "taxa": []}
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{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1519220", "l": "Secretory-Stage Ameloblast", "d": [], "t": []}, {"i": "NCIT:C33524", "l": "Secretory-Stage Ameloblast", "d": ["A cylindrical cell in the innermost layer of the enamel organ which deposits the organic matrix of enamel to create tooth enamel on the surface of the developing tooth."], "t": []}], "preferred_name": "Secretory-Stage Ameloblast", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5855198", "l": "Anti-CD19/CD20 Bicistronic CAR T-cells", "d": [], "t": []}, {"i": "NCIT:C198878", "l": "Anti-CD19/CD20 Bicistronic CAR T-cells", "d": ["A preparation of T-lymphocytes that have been transduced with a bicistronic vector encoding two distinct chimeric antigen receptors (CARs), one against the tumor-associated antigen (TAA) CD19 and the other one against the TAA CD20, with potential immunomodulating and antineoplastic activities. Upon administration, the anti-CD19/CD20 bicistronic CAR T-cells target, bind to and induce selective toxicity in tumor cells expressing CD19 and/or CD20. CD19 and CD20, both transmembrane phosphoglycoproteins expressed on the surface of cells in the B lineage, are often overexpressed on malignant B-cells. By simultaneously targeting two B-cell antigens using two different CARs, this preparation may minimize relapse due to single antigen loss in patients with B-cell malignancies."], "t": []}], "preferred_name": "Anti-CD19/CD20 Bicistronic CAR T-cells", "taxa": []}
{"type": "biolink:Cell", "ic": 92.76600187037766, "identifiers": [{"i": "UMLS:C1510753", "l": "Acantholytic Keratinocyte", "d": [], "t": []}, {"i": "NCIT:C36747", "l": "Acantholytic Keratinocyte", "d": [], "t": []}], "preferred_name": "Acantholytic Keratinocyte", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1268001", "l": "Lymphocyte positive for CD126 antigen", "d": [], "t": []}, {"i": "SNOMEDCT:117441008", "l": "", "d": [], "t": []}], "preferred_name": "Lymphocyte positive for CD126 antigen", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5688428", "l": "Population of all cells positive for progesterone receptor in portion of fluid", "d": [], "t": []}, {"i": "SNOMEDCT:1222876002", "l": "", "d": [], "t": []}], "preferred_name": "Population of all cells positive for progesterone receptor in portion of fluid", "taxa": []}
{"type": "biolink:Cell", "ic": 90.871710685482, "identifiers": [{"i": "CL:0000649", "l": "spinous cell of epidermis", "d": ["A keratinocyte found within the stratum spinosum (prickle cell layer) of the epidermis, distinguished by numerous intercellular desmosomes, which give it a “prickly” or spiny appearance. Positioned above the mitotically active basal layer and beneath the granular layer, it contributes to the skin’s mechanical strength and barrier function, preventing water loss and pathogen entry. This cell expresses differentiation-specific keratins K1 and K10 in mice, unlike basal cells that express K5 and K14, and lacks the keratohyalin granules found in granular cells, marking its intermediate stage of epidermal differentiation."], "t": []}, {"i": "UMLS:C1181285", "l": "Prickle cell of epidermis", "d": [], "t": []}], "preferred_name": "spinous cell of epidermis", "taxa": []}
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{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C2324104", "l": "Diffuse cone bipolar cell", "d": [], "t": []}], "preferred_name": "Diffuse cone bipolar cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1267805", "l": "HLE+ lymphocyte", "d": [], "t": []}, {"i": "SNOMEDCT:117509004", "l": "", "d": [], "t": []}], "preferred_name": "HLE+ lymphocyte", "taxa": []}
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{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0229952", "l": "Thymic reticulum cell", "d": [], "t": []}, {"i": "SNOMEDCT:50482005", "l": "", "d": [], "t": []}], "preferred_name": "Thymic reticulum cell", "taxa": []}
{"type": "biolink:Cell", "ic": 92.76600187037766, "identifiers": [{"i": "UMLS:C1709677", "l": "Bone Marrow Myeloid Stem Cell with Some Degree of Commitment to the Erythroid Lineage", "d": [], "t": []}, {"i": "NCIT:C43220", "l": "Bone Marrow Myeloid Stem Cell with Some Degree of Commitment to the Erythroid Lineage", "d": [], "t": []}], "preferred_name": "Bone Marrow Myeloid Stem Cell with Some Degree of Commitment to the Erythroid Lineage", "taxa": []}
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{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1979650", "l": "Blasts.cytoplasmic CD34", "d": [], "t": []}], "preferred_name": "Blasts.cytoplasmic CD34", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5173469", "l": "Monocytes+Macrophages | Pericardial fluid | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Monocytes+Macrophages | Pericardial fluid | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": 88.20185721311867, "identifiers": [{"i": "UMLS:C1708645", "l": "Malignant Large Multinucleated Histiocyte", "d": [], "t": []}, {"i": "NCIT:C43256", "l": "Malignant Large Multinucleated Histiocyte", "d": [], "t": []}], "preferred_name": "Malignant Large Multinucleated Histiocyte", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5886246", "l": "Cells.chromosome Y", "d": [], "t": []}], "preferred_name": "Cells.chromosome Y", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "CL:1000379", "l": "type 1 vestibular sensory cell of epithelium of macula of utricle of membranous labyrinth", "d": ["A type I vestibular sensory cell that is part of the epithelium of macula of utricle of membranous labyrinth."], "t": []}, {"i": "UMLS:C2339111", "l": "Type 1 vestibular sensory cell of epithelium of macula of utricle of membranous labyrinth", "d": [], "t": []}], "preferred_name": "type 1 vestibular sensory cell of epithelium of macula of utricle of membranous labyrinth", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5419437", "l": "Cord Blood Derived CAR T-Cells", "d": [], "t": []}, {"i": "NCIT:C172058", "l": "Cord Blood Derived CAR T-Cells", "d": ["A preparation of umbilical cord blood (CB)-derived T-lymphocytes that are genetically engineered to express a chimeric antigen receptor (CAR) that targets an as of yet unidentified tumor-associated antigen (TAA), with potential immunomodulatory and antineoplastic activities. Upon administration of the cord blood derived CAR T-cells, the T-cells target, bind to and induce selective cytotoxicity in tumor cells expressing the TAA."], "t": []}], "preferred_name": "Cord Blood Derived CAR T-Cells", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C0682695", "l": "Renshaw Cells", "d": [], "t": []}, {"i": "NCIT:C33463", "l": "Renshaw Cell", "d": ["An inhibitory interneuron in the ventral horn of gray matter of the spinal cord that is held to be reciprocally innervated with a motoneuron so that nerve impulses received by way of processes of the motoneuron stimulate inhibitory impulses back to the motoneuron along an axon of the internuncial cell."], "t": []}, {"i": "MESH:D066293", "l": "Renshaw Cells", "d": [], "t": []}], "preferred_name": "Renshaw Cells", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1440353", "l": "CD74+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:1372930004", "l": "", "d": [], "t": []}], "preferred_name": "CD74+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1328049", "l": "LMP2A-Specific Cytotoxic T-Lymphocytes", "d": [], "t": []}, {"i": "NCIT:C62784", "l": "LMP2A-Specific Cytotoxic T-Lymphocytes", "d": ["A preparation of cytotoxic T-lymphocytes (CTL), specifically reactive to Epstein-Barr virus (EBV) latent membrane protein-2A (LMP2A), with potential antineoplastic activity. T-lymphocytes are exposed ex vivo to dendritic cells (DCs) transfected with a replication-deficient adenovirus encoding EBV LMP2A. Subsequently, LMP2A-specific CTLs are exposed to EBV infected cells transfected with adenovirus encoding LMP2A, thereby further stimulating CTLs. Administered to patients with EBV-positive tumors, LMP2A-specific CTLs target LMP2A-positive cells, resulting in cell lysis and inhibition of cancer cell proliferation. EBV LMP2A may be expressed in various malignancies, including nasopharyngeal carcinoma and Hodgkin and non-Hodgkin lymphomas."], "t": []}], "preferred_name": "LMP2A-Specific Cytotoxic T-Lymphocytes", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5157266", "l": "CD11a blasts | Bone marrow | Cell markers", "d": [], "t": []}], "preferred_name": "CD11a blasts | Bone marrow | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": 42.09198385334688, "identifiers": [{"i": "UMLS:C1514098", "l": "Neoplastic Smooth Muscle Cell", "d": [], "t": []}, {"i": "NCIT:C36937", "l": "Neoplastic Smooth Muscle Cell", "d": ["A neoplastic mesenchymal cell that originates from a smooth muscle cell."], "t": []}], "preferred_name": "Neoplastic Smooth Muscle Cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1440340", "l": "CD62P Cells", "d": [], "t": []}, {"i": "SNOMEDCT:1372917000", "l": "", "d": [], "t": []}], "preferred_name": "CD62P Cells", "taxa": []}
{"type": "biolink:Cell", "ic": 76.9766555310214, "identifiers": [{"i": "UMLS:C1518224", "l": "Malignant Neuroendocrine Spindle Cell", "d": [], "t": []}, {"i": "NCIT:C36854", "l": "Malignant Neuroendocrine Spindle Cell", "d": [], "t": []}], "preferred_name": "Malignant Neuroendocrine Spindle Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "UMLS:C5575599", "l": "Fibroblastic Reticular Cell", "d": [], "t": []}, {"i": "NCIT:C13057", "l": "Fibroblastic Reticular Cell", "d": ["A cell with processes making contact with those of other similar cells to form a cellular sheath for a network of reticular fibers, which constitutes the stroma of all secondary lymphoid organs."], "t": []}], "preferred_name": "Fibroblastic Reticular Cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5426958", "l": "Epithelial cells.squamous | Bronchial | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Epithelial cells.squamous | Bronchial | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0009041", "l": "tuft cell of colon", "d": ["A tuft cell that is part of the colonic epithelium, primarily adapted for microbial sensing in the dense colonic microbiota. Unlike its small intestinal counterpart, it does not participate in parasite-driven tuft cell–ILC2 circuits. Instead, it detects bacterial metabolites via taste-signaling pathways (Strine and Craig, 2022). The colonic tuft cell plays a key role in epithelial repair, modulates inflammatory responses through IL-25 secretion, and contributes to intestinal homeostasis by balancing microbiome interactions (Sebastian et al., 2021)."], "t": []}], "preferred_name": "tuft cell of colon", "taxa": []}
{"type": "biolink:Cell", "ic": 65.14534053865317, "identifiers": [{"i": "CL:0000123", "l": "neuron associated cell (sensu Vertebrata)", "d": [], "t": []}], "preferred_name": "neuron associated cell (sensu Vertebrata)", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5181331", "l": "Spermatids | Semen | Fertility testing", "d": [], "t": []}], "preferred_name": "Spermatids | Semen | Fertility testing", "taxa": []}
{"type": "biolink:Cell", "ic": 77.17927671370501, "identifiers": [{"i": "UMLS:C1514069", "l": "Neoplastic Polygonal Cell with Abundant Granular Cytoplasm", "d": [], "t": []}, {"i": "NCIT:C36852", "l": "Neoplastic Polygonal Cell with Abundant Granular Cytoplasm", "d": [], "t": []}], "preferred_name": "Neoplastic Polygonal Cell with Abundant Granular Cytoplasm", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5157442", "l": "CD3+CD4+CD27-CD45RO+CD62L- cells | Blood | Cell markers", "d": [], "t": []}], "preferred_name": "CD3+CD4+CD27-CD45RO+CD62L- cells | Blood | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C4331503", "l": "Virus-specific Cytotoxic T-lymphocytes", "d": [], "t": []}, {"i": "NCIT:C131870", "l": "Virus-specific Cytotoxic T-lymphocytes", "d": ["A population of cytotoxic T-lymphocytes (CTLs) specifically reactive to one or more pre-selected viruses, with potential antiviral activity. Upon infusion, after an allogeneic hematopoietic cell transplant (HCT) or in other immunodeficient states, these CTLs help reconstitute viral-specific CTL responses and kill virally infected cells, thereby inhibiting viral infection in immunocompromised patients."], "t": []}], "preferred_name": "Virus-specific Cytotoxic T-lymphocytes", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:1000695", "l": "kidney interstitial alternatively activated macrophage", "d": [], "t": []}], "preferred_name": "kidney interstitial alternatively activated macrophage", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5827917", "l": "donislecel-jujn", "d": [], "t": []}], "preferred_name": "donislecel-jujn", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C3899996", "l": "Autologous MAGE-A3-specific HLA-A*01-Restricted T Cell Receptor Gene Engineered Lymphocytes", "d": [], "t": []}, {"i": "NCIT:C116711", "l": "Autologous MAGE-A3-specific HLA-A*01-Restricted T Cell Receptor Gene Engineered Lymphocytes", "d": ["Human autologous T-lymphocytes transduced with a retroviral vector encoding a T-cell receptor (TCR) specific for the human leukocyte antigen (HLA)-A*01-restricted, human melanoma-associated antigen A3 (MAGE-A3), with potential antineoplastic activity. Peripheral blood mononuclear cells (PBMCs) are isolated from a patient, transduced with an anti-MAGE-A3-HLA-A*01 restricted TCR, expanded ex vivo, and reintroduced into the HLA-A*01-positive patient. Then, the autologous MAGE-A3-specific, HLA-A*01-restricted TCR gene engineered lymphocytes bind to tumor cells expressing the MAGE-A3 antigen, which may increase cell death and halt the growth of MAGE-A3-expressing cancer cells. The tumor-associated antigen MAGE-A3 is overexpressed by a variety of cancer cell types."], "t": []}], "preferred_name": "Autologous MAGE-A3-specific HLA-A*01-Restricted T Cell Receptor Gene Engineered Lymphocytes", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5216209", "l": "Erythrocytes.nucleated|NCnc|Pt|Synv fld", "d": [], "t": []}], "preferred_name": "Erythrocytes.nucleated|NCnc|Pt|Synv fld", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "CL:0002020", "l": "GlyA-positive reticulocytes", "d": ["A reticulocyte that is GlyA-positive."], "t": []}], "preferred_name": "GlyA-positive reticulocytes", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "CL:4030043", "l": "matrix D1 medium spiny neuron", "d": ["A DRD1-expressing medium spiny neuron that is part of a matrix compartment of dorsal striatum."], "t": []}], "preferred_name": "matrix D1 medium spiny neuron", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0002037", "l": "CD2-positive, CD5-positive, CD44-positive alpha-beta intraepithelial T cell", "d": ["Intraepithelial T cells with a memory phenotype of CD2-positive, CD5-positive, and CD44-positive."], "t": []}], "preferred_name": "CD2-positive, CD5-positive, CD44-positive alpha-beta intraepithelial T cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5221180", "l": "CTX001", "d": [], "t": []}], "preferred_name": "CTX001", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C2346885", "l": "Autologous LMP1-/LMP2- Specific Cytotoxic T-Lymphocytes", "d": [], "t": []}, {"i": "NCIT:C70836", "l": "Autologous LMP1-/LMP2- Specific Cytotoxic T-Lymphocytes", "d": ["A preparation of cytotoxic T-lymphocytes (CTL), specifically reactive to the Epstein-Barr virus (EBV) latent membrane proteins (LMP) 1 and 2, with potential antineoplastic activity. Autologous dendritic cells and EBV-infected lymphoblastoid cell lines (LCL) from patients with EBV-positive nasopharyngeal carcinoma (NPC) are transduced with an LMP1/LMP2-expressing adenoviral vector, are irradiated, and then are used to stimulate and expand autologous CTL to produce autologous LMP1-/LMP2-specific CTL ex vivo. Administration of autologous LMP1-/LMP2- specific cytotoxic T-lymphocytes may result in a specific CTL response against tumor cells expressing LMP1 and LMP2, resulting in cell lysis and inhibition of tumor cell proliferation in vivo. Among a limited set of viral antigens expressed by NPC cells, LMP1 and LMP2 are weak immunogens which, nevertheless, are capable of inducing a T-lymphocyte response."], "t": []}], "preferred_name": "Autologous LMP1-/LMP2- Specific Cytotoxic T-Lymphocytes", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:1000394", "l": "myoepithelial cell of intralobular lactiferous duct", "d": ["A myoepithelial cell that is part of the intralobular part of terminal lactiferous duct."], "t": []}, {"i": "UMLS:C1179047", "l": "Myoepithelial cell of intralobular lactiferous duct", "d": [], "t": []}], "preferred_name": "myoepithelial cell of intralobular lactiferous duct", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0312867", "l": "Sensitized platelet", "d": [], "t": []}, {"i": "SNOMEDCT:65533007", "l": "", "d": [], "t": []}], "preferred_name": "Sensitized platelet", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0019029", "l": "centrilobular region hepatocyte", "d": ["Any hepatocyte that is part of the liver lobule centrilobular region. These cells are the primary location for the biotransformation of drugs."], "t": []}], "preferred_name": "centrilobular region hepatocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4310114", "l": "SN SEMA5A GABA GABAergic interneuron (Primate)", "d": ["A GABAergic interneuron of the Primates brain. These cells are located in the striatum, subthalamic nucleus, substantia nigra . Reference transcriptomic data for this type can be found in the dataset/taxonomy - HMBA Basal Ganglia Consensus Taxonomy in cell set Group:SN SEMA5A GABA."], "t": []}], "preferred_name": "SN SEMA5A GABA GABAergic interneuron (Primate)", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5170952", "l": "Leukocytes other | Cerebral spinal fluid | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Leukocytes other | Cerebral spinal fluid | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "CL:0020003", "l": "internal globus pallidus core projecting neuron", "d": ["A projection neuron that has its soma located in the internal segment of the globus pallidus (GPi) of primates, in the central “core” region. It expresses parvalbumin, is primarily GABAergic, and projects to motor thalamic nuclei including the ventral anterior, ventrolateral, and ventromedial nuclei. In the rodent homolog (entopeduncular nucleus), the core subregion is characterized by concentrated parvalbumin-positive neurons targeting the ventral anterior-ventral lateral thalamic nucleus and receives inputs from the dorsolateral striatum innervated by sensorimotor cortices (Miyamoto & Fukuda, 2022). This neuron corresponds to the sensorimotor output population of the GPi, as demonstrated in human tissue and cross-species comparative studies (Wallace et al., 2017) and by classic tracing in primates (Parent & De Bellefeuille, 1982; Parent et al., 2001)."], "t": []}], "preferred_name": "internal globus pallidus core projecting neuron", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5380992", "l": "Cells.CD8.CMV specific.CMV antigen stimulated gamma interferon producing", "d": [], "t": []}], "preferred_name": "Cells.CD8.CMV specific.CMV antigen stimulated gamma interferon producing", "taxa": []}
{"type": "biolink:Cell", "ic": 72.8241867216765, "identifiers": [{"i": "CL:0002250", "l": "intestinal crypt stem cell", "d": ["A stem cell located in epithelium the based of the crypt of Lieberkuhn. Division of these cells serve both to maintain the stem cell population and produce the transit amplifying cells that are all precursors of all cell types that populate the intestinal epithelium."], "t": []}], "preferred_name": "intestinal crypt stem cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C4726996", "l": "Related Donor Adenovirus-specific Cytotoxic T Cells", "d": [], "t": []}, {"i": "NCIT:C152980", "l": "Related Donor Adenovirus-specific Cytotoxic T Cells", "d": ["A population of allogeneic related donor cytotoxic T-lymphocytes (CTLs) specifically reactive to human adenovirus (Ad) with potential immunomodulating and anti-adenoviral activities. Upon infusion of related donor Ad-specific CTLs, these cells help reconstitute Ad-specific CTL responses in patients at risk of developing Ad infections after allogeneic stem cell transplant or in Ad-infected immunocompromised hosts. These related donor Ad-specific CTLs are manufactured with the CliniMACS Prodigy Cytokine Capture System which facilitates production of the Ad-specific CTLs."], "t": []}], "preferred_name": "Related Donor Adenovirus-specific Cytotoxic T Cells", "taxa": []}
{"type": "biolink:Cell", "ic": 77.38833137893549, "identifiers": [{"i": "CL:0000306", "l": "crystallin accumulating cell", "d": [], "t": []}], "preferred_name": "crystallin accumulating cell", "taxa": []}
{"type": "biolink:Cell", "ic": 77.82747199602274, "identifiers": [{"i": "CL:0007011", "l": "enteric neuron", "d": ["Neuron that is part of the enteric nervous system."], "t": []}], "preferred_name": "enteric neuron", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C2326742", "l": "Goblet cell of epithelium proper of small intestine", "d": [], "t": []}], "preferred_name": "Goblet cell of epithelium proper of small intestine", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C4684462", "l": "Autologous CD4 and CD8 Positive Truncated CD19-expressing Antigen Presenting T-cells", "d": [], "t": []}, {"i": "NCIT:C142205", "l": "Autologous CD4 and CD8 Positive Truncated CD19-expressing Antigen Presenting T-cells", "d": ["A preparation of ex vivo expanded, autologous CD4 and CD8 positive antigen presenting T-cells (T-APCs), genetically modified with a transgene encoding a truncated form of human cluster of differentiation 19 (CD19t), with potential immunostimulating activity. Upon infusion, autologous CD19t-expressing T-APCs may stimulate the proliferation and activation of preadministered therapeutic CD19-targeted chimeric antigen receptor T-cells (CAR-T). This may both improve the persistence of the therapeutic CAR-T-cells and prevent relapse in patients with CD19 positive leukemia or lymphoma. CD19 is a B-cell specific cell surface antigen that is expressed in all B-cell lineage malignancies."], "t": []}], "preferred_name": "Autologous CD4 and CD8 Positive Truncated CD19-expressing Antigen Presenting T-cells", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C3640938", "l": "Allodepleted Haploidentical T Cells-expressing Inducible Caspase 9", "d": [], "t": []}, {"i": "NCIT:C102757", "l": "Allodepleted Haploidentical T Cells-expressing Inducible Caspase 9", "d": ["Allodepleted haploidentical T-lymphocytes transduced with the Gal-V pseudotyped retrovirus vector encoding SFG.iCasp9-2A-deltaCD19, with potential immune reconstitution property. SFG.iCasp9-2A-deltaCD19 contains the suicide gene inducible caspase 9 (iCasp9) linked with a 2A-like cleavable peptide to the selectable marker, truncated human CD19 (deltaCD19). iCasp9 consists of a human FK506 drug-binding domain with an F36V mutation (FKBP12-F36V) linked to human caspase 9 using a short linker (SGGGS). Donor T cell therapy may help control transplant-related viral infections following allogeneic hematopoietic stem cell transplantation. However, even the addition of allodepleted donor T cells can lead to graft-versus-host disease (GVHD). In the event that GVHD begins to develop, the chemical homodimerizer AP1903 can be administered, which binds to the FKBP12-F36V domain activating caspase 9. This results in the death of T cells causing GVHD while sparing the virus reactive T-cells."], "t": []}], "preferred_name": "Allodepleted Haploidentical T Cells-expressing Inducible Caspase 9", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "UMLS:C3899623", "l": "Circulating Stem Cell", "d": [], "t": []}, {"i": "NCIT:C115116", "l": "Circulating Stem Cell", "d": ["A primitive cell found in the peripheral blood that has the ability either to divide and renew the primitive cell pool or to differentiate into various specialized cell types."], "t": []}], "preferred_name": "Circulating Stem Cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0229535", "l": "Pituitary cell", "d": [], "t": []}, {"i": "SNOMEDCT:82406005", "l": "", "d": [], "t": []}], "preferred_name": "Pituitary cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0043291", "l": "X-Chromosome-Bearing Sperm", "d": [], "t": []}], "preferred_name": "X-Chromosome-Bearing Sperm", "taxa": []}
{"type": "biolink:Cell", "ic": 73.85694246010084, "identifiers": [{"i": "CL:0000146", "l": "simple columnar epithelial cell", "d": [], "t": []}], "preferred_name": "simple columnar epithelial cell", "taxa": []}
{"type": "biolink:Cell", "ic": 85.53200374075534, "identifiers": [{"i": "CL:0002664", "l": "cardioblast", "d": ["A stem cell that can give rise to multiple cell types (i.e. smooth muscle, endothelial) in the developing heart."], "t": []}], "preferred_name": "cardioblast", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0002413", "l": "mature Vgamma1.1-positive, Vdelta6.3-negative thymocyte", "d": ["A Vgamma1.1-positive, Vdelta6.3-negative thymocyte that is CD24-negative."], "t": []}], "preferred_name": "mature Vgamma1.1-positive, Vdelta6.3-negative thymocyte", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5427578", "l": "Rods.left", "d": [], "t": []}], "preferred_name": "Rods.left", "taxa": []}
{"type": "biolink:Cell", "ic": 83.63771255585968, "identifiers": [{"i": "CL:0002038", "l": "T follicular helper cell", "d": ["A CD4-positive, CXCR5-positive, CCR7-negative alpha-beta T cell located in follicles of secondary lymph nodes that is BCL6-high, ICOS-high and PD1-high, and stimulates follicular B cells to undergo class-switching and antibody production."], "t": []}, {"i": "UMLS:C5392114", "l": "T Follicular Helper Cells", "d": [], "t": []}, {"i": "NCIT:C176755", "l": "Follicular Helper T Cell", "d": ["A subtype of antigen-experienced CD4+ T cells that are primarily found within B cell follicles near the periphery of secondary lymphoid organs and are involved in the formation and maintenance of germinal centers. These cells express CXCR5 and CD40L and secrete IL-21 and IL-4."], "t": []}, {"i": "MESH:D000084522", "l": "T Follicular Helper Cells", "d": [], "t": []}], "preferred_name": "T follicular helper cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4042033", "l": "pro-opiomelanocortin neuron", "d": ["A neuron of the central nervous system that expresses POMC and synthesizes the POMC precursor polypeptide. This neuron type is located in the arcuate nucleus of the hypothalamus and in the nucleus tractus solitarius of the brainstem. The pro-opiomelanocortin neuron is part of the central melanocortin system and it is involved in regulating energy homeostasis, metabolism, and appetite. This neuronal type responds to hormonal signals such as levels of leptin and insulin, and its activation results in the release of α-melanocyte-stimulating hormone (α-MSH), which acts on melanocortin receptors to suppress food intake and increase energy expenditure."], "t": []}], "preferred_name": "pro-opiomelanocortin neuron", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C4727012", "l": "Autologous CD8+ SLC45A2-specific T Lymphocytes", "d": [], "t": []}, {"i": "NCIT:C153083", "l": "Autologous CD8+ SLC45A2-specific T Lymphocytes", "d": ["A preparation of autologous CD8+ T lymphocytes targeting SLC45A2, a melanoma-associated antigen, with potential immunomodulating and antineoplastic activities. Following peripheral blood mononuclear cell (PBMC) collection and ex vivo expansion of SLC45A2-specific cytotoxic T-lymphocytes (CTLs), the autologous CD8+ SLC45A2-specific CTLs are re-infused into the patient, where they target and lyse SLC45A2-expressing tumor cells. While SLC45A2 is expressed by approximately 80% of cutaneous melanomas, its expression is limited in mature normal melanocytes, allowing high tumor selectivity and reduced potential for autoimmune toxicity."], "t": []}], "preferred_name": "Autologous CD8+ SLC45A2-specific T Lymphocytes", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5163450", "l": "Eosinophils | Vitreous fluid | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Eosinophils | Vitreous fluid | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": 78.80476858236055, "identifiers": [{"i": "UMLS:C1514075", "l": "Neoplastic Promyelocyte", "d": [], "t": []}, {"i": "NCIT:C37072", "l": "Neoplastic Promyelocyte", "d": [], "t": []}], "preferred_name": "Neoplastic Promyelocyte", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4322822", "l": "CD16+ T lymphocyte", "d": [], "t": []}], "preferred_name": "CD16+ T lymphocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5909789", "l": "EGFRt/19-28z/IL-12 CAR T-lymphocytes", "d": [], "t": []}, {"i": "NCIT:C204501", "l": "EGFRt/19-28z/IL-12 CAR T-lymphocytes", "d": ["A preparation of T-lymphocytes that have been genetically modified to express a chimeric antigen receptor (CAR) consisting of an anti-CD19 scFv (single chain variable fragment) fused to the extracellular, transmembrane and intracellular signaling domains of the T-cell co-stimulatory receptor CD28 and the cytoplasmic signaling domain of the zeta chain of the TCR/CD3 complex (CD3-zeta) (19-28z), a truncated form of the human epidermal growth factor receptor (EGFRt), and the human pro-inflammatory cytokine interleukin-12 (IL-12), with potential immunostimulating and antineoplastic activities. Upon administration, EGFRt/19-28z/IL-12 CAR T-lymphocytes are directed to and induce selective toxicity in CD19-expressing tumor cells. In addition, the administered T-cells secrete IL-12 which induces the secretion of interferon-gamma (IFN-g), promotes the activation of natural killer cells (NKs), and induces cytotoxic T-lymphocyte (CTL) responses against tumor cells, which may result in immune-mediated tumor cell death and inhibition of tumor cell proliferation. CD19 antigen is a B-cell specific cell surface antigen expressed in all B-cell lineage malignancies. The CD28 co-stimulatory molecule signaling domain enhances activation and signaling after recognition of CD19. The inclusion of the CD28 signaling domain may increase proliferation of the T-cells and their antitumor activity compared with the inclusion of the CD3-zeta chain alone. Devoid of both ligand binding domains and tyrosine kinase activity, EGFRt facilitates both the in vivo detection of the administered T-cells and the elimination of the administered T-cells through a cetuximab-induced antibody dependent cellular cytotoxicity (ADCC) response."], "t": []}], "preferred_name": "EGFRt/19-28z/IL-12 CAR T-lymphocytes", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5707052", "l": "Anti-mesothelin CAR Vector-transduced T-lymphocytes", "d": [], "t": []}, {"i": "NCIT:C187372", "l": "Anti-mesothelin CAR Vector-transduced T-lymphocytes", "d": ["A preparation of genetically modified T-lymphocytes transduced with a lentiviral vector encoding a chimeric antigen receptor (CAR) specific for the human tumor-associated antigen (TAA) mesothelin (MSLN), with potential immunomodulating and antineoplastic activities. Upon administration, the anti-MSLN CAR vector-transduced T-lymphocytes specifically target and kill MSLN-expressing tumor cells. MSLN, a cell surface glycoprotein involved in cell adhesion, is overexpressed in a variety of cancer cell types."], "t": []}], "preferred_name": "Anti-mesothelin CAR Vector-transduced T-lymphocytes", "taxa": []}
{"type": "biolink:Cell", "ic": 82.62268137420203, "identifiers": [{"i": "CL:0001026", "l": "CD34-positive, CD38-positive common myeloid progenitor", "d": ["A common myeloid progenitor that is CD34-positive, CD38-positive, IL3ra-low, CD10-negative, CD7-negative, CD45RA-negative, and IL-5Ralpha-negative."], "t": []}], "preferred_name": "CD34-positive, CD38-positive common myeloid progenitor", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:1000283", "l": "smooth muscle fiber of transverse colon", "d": ["A smooth muscle cell that is part of the transverse colon."], "t": []}, {"i": "UMLS:C0736249", "l": "Smooth muscle fiber of transverse colon", "d": [], "t": []}], "preferred_name": "smooth muscle fiber of transverse colon", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5448015", "l": "Zedenoleucel", "d": [], "t": []}], "preferred_name": "Zedenoleucel", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4079010", "l": "intrinsic cardiac ganglion TH neuron", "d": ["A catecholaminergic neuron whose soma is located in an intrinsic cardiac ganglion and that expresses tyrosine hydroxylase (TH, encoded by TH), the rate-limiting enzyme in catecholamine biosynthesis. This neuron constitutes a minor subpopulation within the predominantly cholinergic parasympathetic intrinsic cardiac nervous system, identified in adult human cardiac ganglia by immunohistochemistry (Singh et al. 1999, PMID:9918529; Kawano et al. 2003, DOI:10.1007/s003800300005). It participates in local cardiac autonomic regulation, including modulation of heart rate and contractility. Its catecholaminergic phenotype distinguishes it from the majority cholinergic neurons of the same ganglia."], "t": []}], "preferred_name": "intrinsic cardiac ganglion TH neuron", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:1001573", "l": "nasopharyngeal epithelial cell", "d": ["Cell of the nasopharyngeal epithelium."], "t": []}], "preferred_name": "nasopharyngeal epithelial cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5178301", "l": "Promonocytes | Body fluid | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Promonocytes | Body fluid | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:2000012", "l": "fibroblast of pedal digit skin", "d": ["Any skin fibroblast that is part of a pedal digit skin."], "t": []}], "preferred_name": "fibroblast of pedal digit skin", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5977934", "l": "Granulocytes | XXX | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Granulocytes | XXX | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5158327", "l": "Cells.CD3+CD4+CD8+ (Double positive) | Blood | Cell markers", "d": [], "t": []}], "preferred_name": "Cells.CD3+CD4+CD8+ (Double positive) | Blood | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": 88.20185721311867, "identifiers": [{"i": "UMLS:C1517809", "l": "Leukemic Medium-Sized B-Lymphocyte with Basophilic Cytoplasm", "d": [], "t": []}, {"i": "NCIT:C41068", "l": "Leukemic Medium-Sized B-Lymphocyte with Basophilic Cytoplasm", "d": [], "t": []}], "preferred_name": "Leukemic Medium-Sized B-Lymphocyte with Basophilic Cytoplasm", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C2329740", "l": "Set of lymphocytes", "d": [], "t": []}], "preferred_name": "Set of lymphocytes", "taxa": []}
{"type": "biolink:Cell", "ic": 87.18682603146104, "identifiers": [{"i": "CL:0002090", "l": "polar body", "d": ["One of two small cells formed by the first and second meiotic division of oocytes."], "t": []}, {"i": "UMLS:C2331651", "l": "Polar Bodies", "d": [], "t": []}, {"i": "MESH:D059705", "l": "Polar Bodies", "d": [], "t": []}], "preferred_name": "polar body", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:1000698", "l": "kidney resident macrophage", "d": ["A tissue-resident macrophage that is part of some kidney."], "t": []}], "preferred_name": "kidney resident macrophage", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:2000007", "l": "articular chondrocyte of knee joint", "d": ["Chondrocyte forming the hyaline cartilage found in the knee joint."], "t": []}], "preferred_name": "articular chondrocyte of knee joint", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C3639094", "l": "Adenovirus/Cytomegalovirus/Epstein-Barr Virus-specific Allogeneic Cytotoxic T Lymphocytes", "d": [], "t": []}, {"i": "NCIT:C100102", "l": "Adenovirus/Cytomegalovirus/Epstein-Barr Virus-specific Allogeneic Cytotoxic T Lymphocytes", "d": ["Allogeneic tri-viral specific, adenovirus, cytomegalovirus and Epstein-Barr virus (Adv, CMV and EBV or ACE), cytotoxic T-lymphocytes (CTLs) with potential antiviral activity. Donor-derived T-cells were exposed to dendritic cells nucelofected with DNA plasmids encoding Hexon and Penton (Adv), pp65 and IE1 (CMV), and LMP2, EBNA1 and BZLF1 (EBV), all are critical proteins for the proliferation of these viruses, and subsequently maintained in the presence of interleukins 4 and 7 with a novel culture device to expand and sustain the repertoire of CTLs. After an allogeneic hematopoietic stem cell transplant (HSCT), infusion of these CTLs primed towards Adv, CMV and EBV may prevent viral infection by these pathogens."], "t": []}], "preferred_name": "Adenovirus/Cytomegalovirus/Epstein-Barr Virus-specific Allogeneic Cytotoxic T Lymphocytes", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5216316", "l": "Promyelocytes|NCnc|Pt|Bld", "d": [], "t": []}], "preferred_name": "Promyelocytes|NCnc|Pt|Bld", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4052045", "l": "steroidogenic stromal cell of ovary", "d": ["A stromal cell that is part of the ovarian stroma, characterized by its ability to synthesize steroid hormones."], "t": []}], "preferred_name": "steroidogenic stromal cell of ovary", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5400052", "l": "Anti-CD19-CAR Genetically Engineered Autologous T Lymphocytes JCAR017", "d": [], "t": []}], "preferred_name": "Anti-CD19-CAR Genetically Engineered Autologous T Lymphocytes JCAR017", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4079003", "l": "cervical dorsal root ganglion Nav1.9 neuron", "d": ["A nociceptor whose soma is located in the cervical dorsal root ganglion and that expresses the voltage-gated sodium channel Nav1.9 (encoded by SCN11A). This neuron is characterized by a persistent, tetrodotoxin-resistant sodium current that modulates resting membrane potential and amplifies subthreshold depolarizations, contributing to enhanced excitability during inflammation (Dib-Hajj et al. 2002, PMID:11972962). In human DRG, Nav1.9-immunoreactive neurons constitute approximately 26% of TrkA-positive neurons, a significantly higher proportion than the 12% observed in mouse (Rostock et al. 2018, PMID:29229553), suggesting species differences in inflammatory pain processing."], "t": []}], "preferred_name": "cervical dorsal root ganglion Nav1.9 neuron", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1267923", "l": "Lymphocyte positive for CD42C antigen", "d": [], "t": []}, {"i": "SNOMEDCT:117367004", "l": "", "d": [], "t": []}], "preferred_name": "Lymphocyte positive for CD42C antigen", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4758096", "l": "Entire G cell of digestive tract", "d": [], "t": []}, {"i": "SNOMEDCT:781207006", "l": "", "d": [], "t": []}], "preferred_name": "Entire G cell of digestive tract", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4030015", "l": "kidney collecting duct alpha-intercalated cell", "d": ["A renal alpha-intercalated cell that is part of the collecting duct of the renal tubule."], "t": []}], "preferred_name": "kidney collecting duct alpha-intercalated cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4023127", "l": "arcuate nucleus of hypothalamus KNDy neuron", "d": ["a KNDy neuron that is located in the arcuate nucleus of the hypothalamus."], "t": []}], "preferred_name": "arcuate nucleus of hypothalamus KNDy neuron", "taxa": []}
{"type": "biolink:Cell", "ic": 88.20185721311867, "identifiers": [{"i": "UMLS:C0079722", "l": "Lymphocytes, Tumor-Infiltrating", "d": [], "t": []}, {"i": "NCIT:C12546", "l": "Tumor Infiltrating Lymphocyte", "d": ["Lymphocytes that show specificity for autologous tumor cells and can infiltrate a tumor."], "t": []}, {"i": "MESH:D016246", "l": "Lymphocytes, Tumor-Infiltrating", "d": [], "t": []}], "preferred_name": "Lymphocytes, Tumor-Infiltrating", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4047002", "l": "cycling glial cell", "d": ["A(n) glial cell that is cycling."], "t": []}], "preferred_name": "cycling glial cell", "taxa": []}
{"type": "biolink:Cell", "ic": 92.76600187037766, "identifiers": [{"i": "CL:0000999", "l": "CD4-positive CD11b-positive dendritic cell", "d": ["CD8-alpha-negative CD11b-positive dendritic cell is a conventional dendritic cell that is CD11b-positive, CD4-positive and is CD205-negative and CD8-alpha-negative."], "t": []}], "preferred_name": "CD4-positive CD11b-positive dendritic cell", "taxa": []}
{"type": "biolink:Cell", "ic": 92.76600187037766, "identifiers": [{"i": "CL:1001126", "l": "inner renal medulla vasa recta cell", "d": ["Any vasa recta cell that is part of some inner renal medulla vasa recta."], "t": []}], "preferred_name": "inner renal medulla vasa recta cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5157394", "l": "CD22 blasts | Bone marrow | Cell markers", "d": [], "t": []}], "preferred_name": "CD22 blasts | Bone marrow | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1317198", "l": "CD55+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:1372908000", "l": "", "d": [], "t": []}], "preferred_name": "CD55+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C2951489", "l": "Type D enteroendocrine cell of gastric gland", "d": [], "t": []}], "preferred_name": "Type D enteroendocrine cell of gastric gland", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "CL:4030053", "l": "Islands of Calleja granule cell", "d": ["A GABAergic neuron that resides in the islands of calleja and shows the cytoarchitectural and molecular features characteristic of this granule-like cell population. In mice and primates, it expresses D1 and D3 dopamine receptors (Drd1; Drd3), GABAergic markers (GAD1/2) and form densely packed granule cell clusters in the olfactory tubercle within the ventral striatum. Moreover it receives dense dopaminergic input from the VTA, and functionally associated with self-grooming behaviors and depression-like behaviors."], "t": []}], "preferred_name": "Islands of Calleja granule cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1440271", "l": "CD2+CD20+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:1372988003", "l": "", "d": [], "t": []}], "preferred_name": "CD2+CD20+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "UMLS:C1519459", "l": "Spindle-Shaped Meningothelial Cell", "d": [], "t": []}, {"i": "NCIT:C37156", "l": "Spindle-Shaped Meningothelial Cell", "d": [], "t": []}], "preferred_name": "Spindle-Shaped Meningothelial Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 74.64805296934512, "identifiers": [{"i": "UMLS:C1708869", "l": "Malignant Cuboidal Mucous Cell", "d": [], "t": []}, {"i": "NCIT:C47811", "l": "Malignant Cuboidal Mucous Cell", "d": [], "t": []}], "preferred_name": "Malignant Cuboidal Mucous Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:2000094", "l": "nasal cavity respiratory epithelium epithelial cell of viscerocranial mucosa", "d": ["Any epithelial cell of viscerocranial mucosa that is part of a nasal cavity respiratory epithelium."], "t": []}], "preferred_name": "nasal cavity respiratory epithelium epithelial cell of viscerocranial mucosa", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1709904", "l": "Renal Tumor-Reactive Autologous Tumor Infiltrating Lymphocyte", "d": [], "t": []}, {"i": "NCIT:C48817", "l": "Renal Tumor-Reactive Autologous Tumor Infiltrating Lymphocyte", "d": ["Tumor infiltrating lymphocytes (TIL) harvested directly from infiltrate of a patient's renal tumor and cultured with interleukin-2 to expand the TIL cell population. Tumor infiltrating lymphocytes have specific activity against the tumor from which they are derived. Introducing these renal tumor-reactive autologous tumor infiltrating lymphocytes back into the same patient may enhance a cytotoxic T-cell-mediated immune response against the renal cancer cells."], "t": []}], "preferred_name": "Renal Tumor-Reactive Autologous Tumor Infiltrating Lymphocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4307031", "l": "Astro-NT NN_1 Six3os1 astrocyte (Mmus)", "d": ["A astrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Myoc (Mmus), Six3os1 (Mmus), Slc36a2 (Mmus). It is distinguished from other Astro-NT NN_1 cells by expression of Six3os1. These cells are located in the Striatum-like amygdalar nuclei, Olfactory areas, brain , in or close to the regions: Medial amygdalar nucleus . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5211 Astro-NT NN_1."], "t": []}], "preferred_name": "Astro-NT NN_1 Six3os1 astrocyte (Mmus)", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0009040", "l": "stromal cell of lamina propria of colon", "d": ["A stromal cell found in the lamina propria of the colon."], "t": []}], "preferred_name": "stromal cell of lamina propria of colon", "taxa": []}
{"type": "biolink:Cell", "ic": 36.20077502871004, "identifiers": [{"i": "UMLS:C0431085", "l": "Tumor cells, uncertain whether benign or malignant", "d": [], "t": []}, {"i": "NCIT:C12922", "l": "Neoplastic Cell", "d": ["Cells of, or derived from, a tumor."], "t": []}, {"i": "SNOMEDCT:39577004", "l": "", "d": [], "t": []}], "preferred_name": "Tumor cells, uncertain whether benign or malignant", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5216324", "l": "Unidentified cells|NCnc|Pt|Plr fld", "d": [], "t": []}], "preferred_name": "Unidentified cells|NCnc|Pt|Plr fld", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:1000472", "l": "myoepithelial cell of tertiary lactiferous duct", "d": ["A myoepithelial cell that is part of the tertiary lactiferous duct."], "t": []}, {"i": "UMLS:C1184140", "l": "Myoepithelial cell of tertiary lactiferous duct", "d": [], "t": []}], "preferred_name": "myoepithelial cell of tertiary lactiferous duct", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5157372", "l": "CD2 cells | Tissue and Smears | Cell markers", "d": [], "t": []}], "preferred_name": "CD2 cells | Tissue and Smears | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4047007", "l": "immature pericyte", "d": ["A pericyte that is in an early stage of development, found in newly forming or remodeling blood vessels. An immature pericyte is characterized by it's mesenchymal stem cell-like properties and high proliferative capacity, which allows it to differentiate into various types of pericytes and contribute to the structural and functional maturation of the vasculature. Immature pericytes are stellate in new vessels and elongated with less protrusions in remodeling vessels."], "t": []}], "preferred_name": "immature pericyte", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4518152", "l": "Population of all spermatozoa with amorphous head in portion of fluid", "d": [], "t": []}, {"i": "SNOMEDCT:725235007", "l": "", "d": [], "t": []}], "preferred_name": "Population of all spermatozoa with amorphous head in portion of fluid", "taxa": []}
{"type": "biolink:Cell", "ic": 82.62268137420203, "identifiers": [{"i": "UMLS:C1514272", "l": "Postgerminal Center B-Lymphocyte of Unknown Differentiation Stage", "d": [], "t": []}, {"i": "NCIT:C38341", "l": "Postgerminal Center B-Lymphocyte of Unknown Differentiation Stage", "d": [], "t": []}], "preferred_name": "Postgerminal Center B-Lymphocyte of Unknown Differentiation Stage", "taxa": []}
{"type": "biolink:Cell", "ic": 75.2337427109536, "identifiers": [{"i": "CL:4023049", "l": "L5 intratelencephalic projecting glutamatergic neuron of the primary motor cortex", "d": ["An intratelencephalic-projecting glutamatergic neuron with a soma found in L5 of the primary motor cortex."], "t": []}], "preferred_name": "L5 intratelencephalic projecting glutamatergic neuron of the primary motor cortex", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5446871", "l": "Welgenaleucel", "d": [], "t": []}], "preferred_name": "Welgenaleucel", "taxa": []}
{"type": "biolink:Cell", "ic": 92.76600187037766, "identifiers": [{"i": "CL:0002084", "l": "Boettcher cell", "d": ["A Boettcher cell is a polyhedral cells on the basilar membrane of the cochlea, and is located beneath Claudius cells. A Boettcher cell is considered a supporting cell for the organ of Corti, and is present only in the lower turn of the cochlea. These cells interweave with each other, and project microvilli into the intercellular space. Because of their structural specialization, a Boettcher cell is believed to play a significant role in the function of the cochlea. They demonstrate high levels of calmodulin, and may be involved in mediating Ca(2+) regulation and ion transport."], "t": []}], "preferred_name": "Boettcher cell", "taxa": []}
{"type": "biolink:Cell", "ic": 92.76600187037766, "identifiers": [{"i": "UMLS:C1514275", "l": "Postradiation Dysplastic Epithelial Cell", "d": [], "t": []}, {"i": "NCIT:C36804", "l": "Postradiation Dysplastic Epithelial Cell", "d": [], "t": []}], "preferred_name": "Postradiation Dysplastic Epithelial Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0020061", "l": "periductal fibroblast of salivary gland", "d": ["A fibroblast that is part of the stroma of a salivary gland, positioned in the periductal connective tissue surrounding the ductal system. This cell maintains the extracellular matrix framework around salivary gland ducts and participates in immunomodulatory signaling. In the context of Sjögren's syndrome, periductal fibroblasts respond to IL-13 stimulation by upregulating VCAM-1, PDPN, and ICAM-1, contributing to the formation of tertiary lymphoid structures (Nayar et al., 2019)."], "t": []}], "preferred_name": "periductal fibroblast of salivary gland", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5442136", "l": "bb2121", "d": [], "t": []}], "preferred_name": "bb2121", "taxa": []}
{"type": "biolink:Cell", "ic": 82.16838616155795, "identifiers": [{"i": "CL:4023083", "l": "obsolete chandelier cell", "d": ["A GABAergic interneuron that selectively innervates the axon initial segment of pyramidal cells. Their local axonal clusters are formed by high-frequency branching at shallow angles, often ramifying around, above or below their somata with a high bouton density. The characteristic terminal portions of the axon form short vertical rows of boutons, resembling the candlesticks and candles of a chandelier. Chandelier cells can be multipolar or bitufted."], "t": []}], "preferred_name": "obsolete chandelier cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4307012", "l": "CBX MLI Cdh22 Gaba molecular layer interneuron (Mmus)", "d": ["A molecular layer interneuron of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Cdh1 (Mmus), Acvr1c (Mmus), Adamts15 (Mmus), Pax2 (Mmus). It is distinguished from other CB GABA cells by expression of Cdh1, Acvr1c, Adamts15, Pax2. It is GABAergic. These cells are located in the Cerebellum, brain . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5192 CBX MLI Cdh22 Gaba_1.", "A molecular layer interneuron of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Cdh1 (Mmus), Acvr1c (Mmus), Adamts15 (Mmus), Pax2 (Mmus). It is distinguished from other CB GABA cells by expression of Cdh1, Acvr1c, Adamts15, Pax2. It is GABAergic (inferred from expression of Gad1, Gad2, Slc32a1). These cells are located in the Cerebellum, brain . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5192 CBX MLI Cdh22 Gaba_1."], "t": []}], "preferred_name": "CBX MLI Cdh22 Gaba molecular layer interneuron (Mmus)", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1317200", "l": "CD59+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:1372910003", "l": "", "d": [], "t": []}], "preferred_name": "CD59+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": 85.53200374075534, "identifiers": [{"i": "CL:0002658", "l": "glandular cell of the large intestine", "d": ["A glandular epithelial cell of the large intestine."], "t": []}, {"i": "UMLS:C1517726", "l": "Glandular cell of large intestine", "d": [], "t": []}, {"i": "NCIT:C32925", "l": "Large Intestinal Glandular Cell", "d": ["Intestinal enterocytes are low columnar to cuboidal cells comprising the majority of the epithelial tissue in the intestine and colon. They have both absorptive and secretory functions, absorbing water, sodium and short-chain fatty acids while secreting bicarbonate and potassium. Colonocytes originate from stem cells located at the base of the crypts. Enterocyte production, differentiation, and turnover occurs in topographically distinct regions of crypts. The transformation of colonic epithelial cells are frequently involved in colorectal cancers."], "t": []}], "preferred_name": "glandular cell of the large intestine", "taxa": []}
{"type": "biolink:Cell", "ic": 53.88114958517324, "identifiers": [{"i": "CL:0000081", "l": "blood cell", "d": ["A cell found predominately in the blood."], "t": []}, {"i": "UMLS:C0005773", "l": "Blood Cells", "d": [], "t": []}, {"i": "NCIT:C12519", "l": "Peripheral Blood Cell", "d": ["A general term describing the three cellular components of blood (white blood cells, red blood cells, and platelets), all which are made in the bone marrow. (Lymphoma Information Network Glossary)"], "t": []}, {"i": "MESH:D001773", "l": "Blood Cells", "d": [], "t": []}, {"i": "SNOMEDCT:63370004", "l": "", "d": [], "t": []}], "preferred_name": "blood cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1515077", "l": "Olfactory Supporting Cell", "d": [], "t": []}, {"i": "NCIT:C13152", "l": "Olfactory Supporting Cell", "d": ["A cell that serves to provide support and protection to the olfactory epithelium."], "t": []}], "preferred_name": "Olfactory Supporting Cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5425000", "l": "CD3+CD8+CD27+CD45RO+CD62L+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:1373266003", "l": "", "d": [], "t": []}], "preferred_name": "CD3+CD8+CD27+CD45RO+CD62L+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0002155", "l": "echinocyte", "d": ["A crenated erythrocyte with 30+ crenations, bumps or spurs that are the result of damage due to age or disease."], "t": []}], "preferred_name": "echinocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4079020", "l": "sacral dorsal root ganglion CGRP neuron", "d": ["A peptidergic nociceptor whose soma is located in the sacral dorsal root ganglion, characterized by expression of calcitonin gene-related peptide (CGRP, encoded by CALCA). This small- to medium-diameter neuron belongs to the TrkA-positive peptidergic subpopulation and typically co-expresses substance P. It innervates peripheral tissues including skin and viscera, where it mediates neurogenic inflammation and nociceptive signalling through release of CGRP from peripheral terminals during tissue injury (Haberberger et al. 2019, PMID:31293388). In human DRG, CGRP-immunoreactive neurons represent a substantial proportion of nociceptors, comparable to the pattern observed in rodents (Rostock et al. 2018, PMID:29229553)."], "t": []}], "preferred_name": "sacral dorsal root ganglion CGRP neuron", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5157396", "l": "CD22 cells | Blood | Cell markers", "d": [], "t": []}], "preferred_name": "CD22 cells | Blood | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0229636", "l": "Neutrophilic promyelocyte", "d": [], "t": []}, {"i": "SNOMEDCT:34254002", "l": "", "d": [], "t": []}], "preferred_name": "Neutrophilic promyelocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1512099", "l": "Dyskeratotic Keratinocyte", "d": [], "t": []}, {"i": "NCIT:C36746", "l": "Dyskeratotic Keratinocyte", "d": [], "t": []}], "preferred_name": "Dyskeratotic Keratinocyte", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5212874", "l": "Monocytes.HLA-DR", "d": [], "t": []}], "preferred_name": "Monocytes.HLA-DR", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1292100", "l": "IgG B lymphocyte", "d": [], "t": []}, {"i": "SNOMEDCT:115606002", "l": "", "d": [], "t": []}], "preferred_name": "IgG B lymphocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C0369668", "l": "Microcytic erythrocyte (cell)", "d": [], "t": []}, {"i": "NCIT:C37034", "l": "Microcytic Red Blood Cell", "d": [], "t": []}, {"i": "SNOMEDCT:397022008", "l": "", "d": [], "t": []}], "preferred_name": "Microcytic erythrocyte (cell)", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5426634", "l": "CD3-CD14-CD19+CD45+DOCK8+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:1373224004", "l": "", "d": [], "t": []}], "preferred_name": "CD3-CD14-CD19+CD45+DOCK8+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4042008", "l": "fibrous astrocyte", "d": ["A cell type located in the first layer of the neocortex with radial protrusions extending transversely into the deeper cortex layers, herby facilitating communication across neurons, astrocytes, capillaries, meninges and cerebrospinal fluid through contact with neurons, pia mater and capillaries."], "t": []}], "preferred_name": "fibrous astrocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 90.871710685482, "identifiers": [{"i": "CL:0002481", "l": "peritubular myoid cell", "d": ["The flattened smooth myoepithelial cells of mesodermal origin that lie just outside the basal lamina of the seminiferous tubule."], "t": []}], "preferred_name": "peritubular myoid cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5206589", "l": "Autologous CD138-specific CAR T-cells", "d": [], "t": []}, {"i": "NCIT:C162482", "l": "Autologous CD138-specific CAR T-cells", "d": ["A preparation of autologous T-lymphocytes that have been engineered to express a chimeric antigen receptor (CAR) specific for syndecan-1 (CD138), with potential immunomodulating and antineoplastic activities. Upon administration, the autologous CD138 CAR-expressing T-cells target and induce selective toxicity in syndecan-1-expressing tumor cells. Syndecan-1, a type 1 transmembrane proteoglycan and tumor-associated antigen (TAA), is overexpressed in a variety of cancer cells and plays a key role in the regulation of cell growth, differentiation, and adhesion."], "t": []}], "preferred_name": "Autologous CD138-specific CAR T-cells", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C4055424", "l": "Autologous NKG2D CAR-CD3zeta-DAP10-expressing T-Lymphocytes CYAD-01", "d": [], "t": []}, {"i": "NCIT:C121536", "l": "Autologous NKG2D CAR-CD3zeta-DAP10-expressing T-Lymphocytes CYAD-01", "d": ["A preparation of autologous peripheral blood T-lymphocytes (PBTLs) that have been genetically modified and transduced with a retroviral vector to express a chimeric antigen receptor (CAR) encoding full-length human natural-killer group 2, member D receptor protein (NKG2D or KLRK1) fused to the CD3zeta cytoplasmic signaling domain and containing the naturally-expressed adaptor molecule DNAX-activating protein of 10 kDa (DAP10), with potential immunostimulating and antineoplastic activities. Upon infusion back into the patient, autologous NKG2D CAR-CD3zeta-DAP10-expressing T-lymphocytes CYAD-01 specifically recognize and bind to tumor cells expressing NKG2D ligands. This induces secretion of pro-inflammatory cytokines and results in the lysis of NKG2D ligand-expressing tumor cells. In addition, CYAD-01 targets, binds to and kills NKG2D ligand expressing tumor-associated endothelial cells in the neovasculature and immunosuppressive cells, such as regulatory T-cells (Tregs) and myeloid-derived suppressor cells (MDSCs) in the tumor microenvironment (TME) that express NKG2D ligands. It also activates macrophages within the TME. Ligands for NKG2D, such as MHC class I chain-related protein A (MICA), MICB, and members of the UL16-binding proteins (ULBP)/retinoic acid early transcript 1 (RAET1) family, are overexpressed on infected cells and most cancer cell types, but are not expressed on most normal, healthy cells. NKG2D, a dimeric, type II transmembrane protein expressed on human natural killer (NK) and certain T-cells, in association with the natural adaptive protein DAP10, promotes the elimination of NKG2D ligand-expressing cells. The CD3zeta signaling domain and DAP10 provide co-stimulatory signaling upon ligand binding, enhance the secretion of pro-inflammatory cytokines in response to binding to NKG2D ligand-expressing tumor cells and enhances T-cell cytotoxicity. DAP10 also associates with and stabilizes NKG2D, which facilitates expression of the NKG2D-CAR-CD3zeta construct at the cell surface."], "t": []}], "preferred_name": "Autologous NKG2D CAR-CD3zeta-DAP10-expressing T-Lymphocytes CYAD-01", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:1000803", "l": "kidney inner medulla interstitial cell", "d": ["A cell that is part of an interstitial compartment of an inner renal medulla."], "t": []}], "preferred_name": "kidney inner medulla interstitial cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5690735", "l": "Mucosa-Associated Lymphoid Tissue M Cells", "d": [], "t": []}], "preferred_name": "Mucosa-Associated Lymphoid Tissue M Cells", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5174638", "l": "Neutrophils.dysplastic | Blood | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Neutrophils.dysplastic | Blood | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:2000023", "l": "spinal cord ventral column interneuron", "d": ["Any interneuron that is part of a spinal cord ventral column."], "t": []}], "preferred_name": "spinal cord ventral column interneuron", "taxa": []}
{"type": "biolink:Cell", "ic": 76.78008365410358, "identifiers": [{"i": "CL:4023058", "l": "mesothelial fibroblast of the leptomeninx", "d": ["A mesothelial fibroblast found in the leptomeninx."], "t": []}], "preferred_name": "mesothelial fibroblast of the leptomeninx", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "CL:4006000", "l": "fibroblast of breast", "d": ["A fibroblast that is part of the breast."], "t": []}], "preferred_name": "fibroblast of breast", "taxa": []}
{"type": "biolink:Cell", "ic": 47.67415476571199, "identifiers": [{"i": "CL:0002320", "l": "connective tissue cell", "d": ["A cell of the supporting or framework tissue of the body, which includes adipose tissue, cartilage, and bone. In vertebrates, this cell arises chiefly from the embryonic mesoderm and, in cranial regions, from neural crest."], "t": []}, {"i": "UMLS:C0009781", "l": "Connective Tissue Cells", "d": [], "t": []}, {"i": "NCIT:C12555", "l": "Connective and Soft Tissue Cell", "d": ["A non-epithelial cell of mesodermal origin that is found in mesenchymal tissue and functions to support, surround, or protect other structures or organs in the body."], "t": []}, {"i": "MESH:D003239", "l": "Connective Tissue Cells", "d": [], "t": []}], "preferred_name": "connective tissue cell", "taxa": []}
{"type": "biolink:Cell", "ic": 86.30756602822301, "identifiers": [{"i": "UMLS:C1513984", "l": "Neoplastic Histiocyte", "d": [], "t": []}, {"i": "NCIT:C36888", "l": "Neoplastic Histiocyte", "d": [], "t": []}], "preferred_name": "Neoplastic Histiocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:1000305", "l": "fibroblast of connective tissue of glandular part of prostate", "d": ["A fibroblast that is part of the connective tissue of glandular part of prostate."], "t": []}, {"i": "UMLS:C2323784", "l": "Fibroblast of connective tissue of glandular part of prostate", "d": [], "t": []}], "preferred_name": "fibroblast of connective tissue of glandular part of prostate", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5707600", "l": "BCMA-targeted LCAR-BCDR Cells", "d": [], "t": []}, {"i": "NCIT:C188123", "l": "BCMA-targeted LCAR-BCDR Cells", "d": ["A preparation of T-lymphocytes that have been genetically modified to express a chimeric antigen receptor (CAR) specific for the B-cell maturation antigen (BCMA; tumor necrosis factor receptor superfamily member 17; TNFRSF17), with potential immunostimulating and antineoplastic activities. Upon administration, BCMA-targeted LCAR-BCDR cells specifically recognize and kill BCMA-expressing tumor cells. BCMA, a tumor specific antigen and a receptor for both a proliferation-inducing ligand (APRIL) and B-cell activating factor (BAFF), is a member of the tumor necrosis factor (TNF) receptor superfamily and plays a key role in plasma cell survival; it is found on the surfaces of plasma cells and overexpressed on malignant plasma cells."], "t": []}], "preferred_name": "BCMA-targeted LCAR-BCDR Cells", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C4725117", "l": "Anti-CD3/MUC1 Antibody-armed PD-1 Inhibitor-induced Cytokine-induced Killer Cells", "d": [], "t": []}, {"i": "NCIT:C148543", "l": "Anti-CD3/MUC1 Antibody-armed PD-1 Inhibitor-induced Cytokine-induced Killer Cells", "d": ["A preparation of cytokine-induced killer cells (CIKs), which have been exposed, ex vivo, to a specific set of cytokines and a programmed cell death protein 1 (PD-1) inhibitor, mixed with a bispecific anti-cluster of differentiation 3 (CD3)/anti-mucin-1 (MUC1) antibody, with potential anti-tumor cytotoxic activity. Upon administration of the anti-CD3/MUC1 antibody-armed PD-1 inhibitor-induced CIKs, the antibody moiety binds to both CD3 on the CIKs and MUC1 on cancer cells. This crosslinks the CIKs and tumor cells, which allows the CIKs to target and lyse MUC1-expressing cancer cells. PD-1 blockade activates the CIKs. The cytokines used, usually interferon-gamma (IFNg), interleukin 1 (IL-1), and IL-2, stimulate the proliferation and maturation of peripheral blood mononuclear cells (PBMCs) into CIK cells. Anti-CD3 stimulation allows for the CIKs' improved lytic activity."], "t": []}], "preferred_name": "Anti-CD3/MUC1 Antibody-armed PD-1 Inhibitor-induced Cytokine-induced Killer Cells", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1516727", "l": "Common Thymocyte", "d": [], "t": []}, {"i": "NCIT:C32360", "l": "Common Thymocyte", "d": ["A lymphocyte found in the thymus. It is a precursor to a mature T-lymphocyte."], "t": []}], "preferred_name": "Common Thymocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 75.876659701315, "identifiers": [{"i": "UMLS:C1709196", "l": "Neoplastic Retinal Ganglion Cell", "d": [], "t": []}, {"i": "NCIT:C42604", "l": "Neoplastic Retinal Ganglion Cell", "d": [], "t": []}], "preferred_name": "Neoplastic Retinal Ganglion Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 71.48355502057495, "identifiers": [{"i": "UMLS:C5856882", "l": "Therapeutic Natural Killer Cells Preparation", "d": [], "t": []}, {"i": "NCIT:C201545", "l": "Therapeutic Natural Killer Cells Preparation", "d": ["A preparation of natural killer (NK) cells."], "t": []}], "preferred_name": "Therapeutic Natural Killer Cells Preparation", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5170899", "l": "Leukemia markers | Blood | Cell markers", "d": [], "t": []}], "preferred_name": "Leukemia markers | Blood | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": 86.30756602822301, "identifiers": [{"i": "CL:4030028", "l": "glycinergic amacrine cell", "d": ["An amacrine cell that uses glycine as a neurotransmitter."], "t": []}], "preferred_name": "glycinergic amacrine cell", "taxa": []}
{"type": "biolink:Cell", "ic": 71.93166454101878, "identifiers": [{"i": "CL:0000675", "l": "female gamete", "d": ["A mature sexual reproductive cell of the female germline."], "t": []}], "preferred_name": "female gamete", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5707881", "l": "donislecel", "d": [], "t": []}, {"i": "NCIT:C188575", "l": "Donislecel", "d": [], "t": []}], "preferred_name": "donislecel", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0682541", "l": "polyhedral cell", "d": [], "t": []}], "preferred_name": "polyhedral cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1514520", "l": "Prostatic Glandular Cell", "d": [], "t": []}, {"i": "NCIT:C33409", "l": "Prostatic Glandular Cell", "d": ["A secretory cell that produces and secretes prostatic fluid. Prostatic fluid contains citric acid, the enzyme fibrinolysin that liquefies the semen, acid phosphatase, a number of other enzymes and lipids. The secretion of the prostate is the first fraction of the ejaculate."], "t": []}], "preferred_name": "Prostatic Glandular Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 83.63771255585968, "identifiers": [{"i": "UMLS:C1513988", "l": "Neoplastic Thyroid Gland Oncocyte", "d": [], "t": []}, {"i": "NCIT:C37095", "l": "Neoplastic Thyroid Gland Oncocyte", "d": [], "t": []}], "preferred_name": "Neoplastic Thyroid Gland Oncocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0002585", "l": "retinal blood vessel endothelial cell", "d": ["A blood vessel endothelial cell that is part of the retina."], "t": []}], "preferred_name": "retinal blood vessel endothelial cell", "taxa": []}
{"type": "biolink:Cell", "ic": 77.82747199602274, "identifiers": [{"i": "CL:0000118", "l": "basket cell", "d": ["Basket cells are inhibitory GABAergic interneurons of the brain. In general, dendrites of basket cells are free branching and contain smooth spines. Axons are highly branched. The branched axonal arborizations give rise to basket-like structures that surround the soma of the target cell. Basket cells form axo-somatic synapses, meaning their synapses target somas of other cells."], "t": []}], "preferred_name": "basket cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0229646", "l": "Basophilic myelocyte", "d": [], "t": []}, {"i": "SNOMEDCT:17295002", "l": "", "d": [], "t": []}], "preferred_name": "Basophilic myelocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5557440", "l": "IGV-001", "d": [], "t": []}, {"i": "NCIT:C101257", "l": "IGF-1R Antisense Oligodeoxynucleotide-treated Autologous Glioma Cells IGV-001", "d": ["A preparation of irradiated autologous glioma cells treated ex vivo with IMV-001, an antisense oligodeoxynucleotide of insulin-like growth factor receptor 1 (IGF-1R/AS ODN), and encapsulated within bio-diffusion chambers, with potential antineoplastic activity. The IGF-1R/AS ODN IMV-001-treated autologous glioma cells IGV-001 are encapsulated within implantable and removable bio-diffusion chambers with additional IMV-001, irradiated, and implanted into the patient. The IGF-1R/AS ODN binds to IGF-1R mRNA in glioma cells, and shuts down the translation of IGF-1R in the glioma cells. Downregulation of IGF-1R, in addition to irradiation, induces apoptosis and causes the release of exosomes, which contain tumor-associated antigens (TAAs). The diffusion of exosomes together with the additional IMV-001 from the bio-diffusion chambers may activate the patient's immune system and mount a cytotoxic T-lymphocyte (CTL) response against cells expressing these TAAs. IGF-1R, a receptor tyrosine kinase, is overexpressed in a variety of tumor cell types and is essential for tumor cell growth, transformation and survival."], "t": []}, {"i": "MESH:C000723383", "l": "IGV-001", "d": [], "t": []}], "preferred_name": "IGV-001", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5908094", "l": "Spunoleucel", "d": [], "t": []}], "preferred_name": "Spunoleucel", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5691155", "l": "LTF-303", "d": [], "t": []}], "preferred_name": "LTF-303", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5157651", "l": "CD7+CD3- | White blood cells | Cell markers", "d": [], "t": []}], "preferred_name": "CD7+CD3- | White blood cells | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0003017", "l": "retinal ganglion cell B3 outer", "d": ["A retinal ganglion B cell that has post synaptic terminals in S2."], "t": []}], "preferred_name": "retinal ganglion cell B3 outer", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C2826112", "l": "Autologous NY-ESO-1-Melanoma-Specific CD8+ T-lymphocytes", "d": [], "t": []}, {"i": "NCIT:C82350", "l": "Autologous NY-ESO-1-Melanoma-Specific CD8+ T-lymphocytes", "d": ["A preparation of autologous CD8+ (cytotoxic) T-lymphocytes sensitized to cancer-testis antigen NY-ESO-1 antigen with potential immunostimulating and antineoplastic activities. Autologous CD8+ T-lymphocytes, isolated from a melanoma patient, are exposed to an NY-ESO-1 peptide ex vivo, expanded, and reintroduced into the patient; these tumor-reactive T-cells may stimulate a host immune response against tumor cells expressing the NY-ESO-1 antigen, resulting in tumor cell lysis. NY-ESO-1, an antigen found in normal testis, may be upregulated in various cancers, including bladder, breast, hepatocellular, melanoma, and prostate cancers."], "t": []}], "preferred_name": "Autologous NY-ESO-1-Melanoma-Specific CD8+ T-lymphocytes", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0229538", "l": "Pituitary thyrotropic cell", "d": [], "t": []}, {"i": "SNOMEDCT:33608007", "l": "", "d": [], "t": []}], "preferred_name": "Pituitary thyrotropic cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5157385", "l": "CD20+FMC7+ cells | Cerebral spinal fluid | Cell markers", "d": [], "t": []}], "preferred_name": "CD20+FMC7+ cells | Cerebral spinal fluid | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": 81.34422831136257, "identifiers": [{"i": "CL:0001051", "l": "CD4-positive, CXCR3-negative, CCR6-negative, alpha-beta T cell", "d": ["A CD4-positive, alpha-beta T cell that has the phenotype CXCR3-negative, CCR6-negative."], "t": []}], "preferred_name": "CD4-positive, CXCR3-negative, CCR6-negative, alpha-beta T cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1517355", "l": "GE09 Cell Line", "d": [], "t": []}, {"i": "NCIT:C20258", "l": "GE09", "d": ["Provider: Geron Corporation, Menlo Park, CA. No information from provider. This cell line meets the criteria for the use of human embryonic stem cells by federally funded researchers."], "t": []}], "preferred_name": "GE09 Cell Line", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "MESH:D053058", "l": "Trophozoites", "d": [], "t": []}], "preferred_name": "Trophozoites", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1440140", "l": "Blasts.CD10", "d": [], "t": []}], "preferred_name": "Blasts.CD10", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C3496267", "l": "B4 serotonin cells", "d": [], "t": []}], "preferred_name": "B4 serotonin cells", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1440407", "l": "Cells.t(15;17)(q24.1;q21.1)(PML,RARA)", "d": [], "t": []}], "preferred_name": "Cells.t(15;17)(q24.1;q21.1)(PML,RARA)", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1512548", "l": "Hyperchromatic Endothelial Cell", "d": [], "t": []}, {"i": "NCIT:C37089", "l": "Hyperchromatic Endothelial Cell", "d": [], "t": []}], "preferred_name": "Hyperchromatic Endothelial Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1518630", "l": "Mouse Osteoclast", "d": [], "t": []}, {"i": "NCIT:C22681", "l": "Mouse Osteoclast", "d": [], "t": []}], "preferred_name": "Mouse Osteoclast", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5157539", "l": "CD4+CD25+CD45RO+CD127Low+ cells | Blood | Cell markers", "d": [], "t": []}], "preferred_name": "CD4+CD25+CD45RO+CD127Low+ cells | Blood | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5171659", "l": "Lymphocytes | Body fluid | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Lymphocytes | Body fluid | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5670966", "l": "Renal Cortical Cell", "d": [], "t": []}, {"i": "NCIT:C33455", "l": "Renal Cortical Cell", "d": ["A cuboidal glandular epithelial cell found in the renal cortex."], "t": []}], "preferred_name": "Renal Cortical Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 84.83823963392128, "identifiers": [{"i": "CL:0009005", "l": "salivary gland cell", "d": ["Any cell in a salivary gland."], "t": []}], "preferred_name": "salivary gland cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1440303", "l": "CD39+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:1372876001", "l": "", "d": [], "t": []}], "preferred_name": "CD39+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0524458", "l": "Upper motor neuron", "d": [], "t": []}, {"i": "SNOMEDCT:91769000", "l": "", "d": [], "t": []}], "preferred_name": "Upper motor neuron", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5432279", "l": "Allocetra", "d": [], "t": []}], "preferred_name": "Allocetra", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5908165", "l": "Allogeneic Anti-NY-ESO-1-TCR-IL-15-transduced Cord Blood-derived Natural Killer Cells", "d": [], "t": []}, {"i": "NCIT:C201721", "l": "Allogeneic Anti-NY-ESO-1-TCR-IL-15-transduced Cord Blood-derived Natural Killer Cells", "d": ["A preparation of allogeneic, umbilical cord blood (CB)-derived natural killer cells (NKs) that have been engineered to express a T-cell receptor (TCR) specific for the tumor-associated antigen (TAA) human cancer-testis antigen NY-ESO-1 and interleukin-15 (IL-15), with potential immunostimulating and antineoplastic activities. Upon administration, the allogeneic anti-NY-ESO-1-TCR-IL-15-transduced CB-derived NKs target, bind to and induce selective cytotoxicity in NY-ESO-1-expressing tumor cells. NY-ESO-1 is found in normal testis and on the surface of various tumor cell types. IL-15 is a pro-survival cytokine that promotes persistence of multiple lymphocyte lineages and potentiates the immune response against tumor cells."], "t": []}], "preferred_name": "Allogeneic Anti-NY-ESO-1-TCR-IL-15-transduced Cord Blood-derived Natural Killer Cells", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5418015", "l": "Autologous BCMA-targeted CAR T Cells CC-98633", "d": [], "t": []}, {"i": "NCIT:C173699", "l": "Autologous BCMA-targeted CAR T Cells CC-98633", "d": ["A preparation of autologous T-lymphocytes that have been genetically modified to express a chimeric antigen receptor (CAR) specific for the B-cell maturation antigen (BCMA; tumor necrosis factor receptor superfamily member 17; TNFRSF17), with potential immunostimulating and antineoplastic activities. Upon administration, autologous BCMA-targeted CAR T cells CC-98633 specifically recognize and kill BCMA-expressing tumor cells. BCMA, a tumor specific antigen and a receptor for both a proliferation-inducing ligand (APRIL) and B-cell activating factor (BAFF), is a member of the tumor necrosis factor (TNF) receptor superfamily and plays a key role in plasma cell survival; it is found on the surfaces of plasma cells and overexpressed on malignant plasma cells."], "t": []}], "preferred_name": "Autologous BCMA-targeted CAR T Cells CC-98633", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:1000301", "l": "fibroblast of subepithelial connective tissue of prostatic gland", "d": ["A fibroblast that is part of the subepithelial connective tissue of prostatic gland."], "t": []}, {"i": "UMLS:C2327375", "l": "Fibroblast of subepithelial connective tissue of prostatic gland", "d": [], "t": []}], "preferred_name": "fibroblast of subepithelial connective tissue of prostatic gland", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0002511", "l": "CD11b-low, CD103-negative, langerin-negative lymph node dendritic cell", "d": ["A langerin-negative lymph node dendritic cell that is CD103-negative and CD11b-low."], "t": []}], "preferred_name": "CD11b-low, CD103-negative, langerin-negative lymph node dendritic cell", "taxa": []}
{"type": "biolink:Cell", "ic": 54.17466531244803, "identifiers": [{"i": "CL:0000566", "l": "angioblastic mesenchymal cell", "d": ["A mesenchymal stem cell capable of developing into blood vessel endothelium."], "t": []}], "preferred_name": "angioblastic mesenchymal cell", "taxa": []}
{"type": "biolink:Cell", "ic": 84.21065366064373, "identifiers": [{"i": "CL:0000474", "l": "pericardial nephrocyte", "d": ["An insect renal cell that filters hemolymph and is found with other pericardial nephrocytes in two rows flanking the dorsal vessel."], "t": []}], "preferred_name": "pericardial nephrocyte", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5549471", "l": "CD154 cells | T cells | Cell markers", "d": [], "t": []}], "preferred_name": "CD154 cells | T cells | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "CL:7770005", "l": "beam cell", "d": ["A trabecular meshwork cell that is part of the eye's trabecular meshwork, residing in the uveal and corneoscleral meshwork regions and serving as the primary biological filter in the aqueous humor drainage cascade. This cell exhibits endothelial-like properties, including production of antithrombogenic substances such as tissue plasminogen activator, while also demonstrating phagocytic activity to remove cellular debris from aqueous humour before the fluid moves deeper into the less porous juxtacanalicular tissue."], "t": []}], "preferred_name": "beam cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5171527", "l": "Lupus erythematosus cells | Blood | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Lupus erythematosus cells | Blood | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": 85.53200374075534, "identifiers": [{"i": "UMLS:C1882045", "l": "Neoplastic Columnar Epithelial Cell", "d": [], "t": []}, {"i": "NCIT:C62202", "l": "Neoplastic Columnar Epithelial Cell", "d": [], "t": []}], "preferred_name": "Neoplastic Columnar Epithelial Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0004215", "l": "type 5a cone bipolar cell", "d": ["A type 5 cone bipolar cell with narrowly stratified post synaptic terminals."], "t": []}], "preferred_name": "type 5a cone bipolar cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5432371", "l": "CLBS119", "d": [], "t": []}], "preferred_name": "CLBS119", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C3496149", "l": "A17 cell group", "d": [], "t": []}], "preferred_name": "A17 cell group", "taxa": []}
{"type": "biolink:Cell", "ic": 92.76600187037766, "identifiers": [{"i": "CL:0011002", "l": "lateral motor column neuron", "d": ["A motor neuron that is generated only on limb levels and send axons into the limb mesenchyme."], "t": []}], "preferred_name": "lateral motor column neuron", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5163710", "l": "Erythrocytes | Body fluid | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Erythrocytes | Body fluid | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:1000311", "l": "adipocyte of epicardial fat of left ventricle", "d": ["An adipocyte that is part of the epicardial fat of left ventricle."], "t": []}, {"i": "UMLS:C2326607", "l": "Adipocyte of epicardial fat of left ventricle", "d": [], "t": []}], "preferred_name": "adipocyte of epicardial fat of left ventricle", "taxa": []}
{"type": "biolink:Cell", "ic": 76.9766555310214, "identifiers": [{"i": "CL:0002613", "l": "striatum neuron", "d": ["A neuron of the striatum."], "t": []}], "preferred_name": "striatum neuron", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:1000287", "l": "myocyte of anterior internodal tract", "d": ["A muscle cell that is part of the anterior internodal tract."], "t": []}, {"i": "UMLS:C2335684", "l": "Myocyte of anterior internodal tract", "d": [], "t": []}], "preferred_name": "myocyte of anterior internodal tract", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "UMLS:C0037888", "l": "Spherocytes", "d": [], "t": []}, {"i": "NCIT:C12525", "l": "Spherocyte", "d": ["An abnormally small appearing red blood cell that is sphere-shaped and lacks the characteristic central pallor due to cell membrane loss with preservation of cellular contents."], "t": []}, {"i": "MESH:D013102", "l": "Spherocytes", "d": [], "t": []}, {"i": "SNOMEDCT:259682008", "l": "", "d": [], "t": []}], "preferred_name": "Spherocytes", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4310131", "l": "STRd D1/D2-hybrid medium spiny neuron (Primate)", "d": ["A D1/D2-hybrid medium spiny neuron of the Primates brain. These cells are located in the striatum . Reference transcriptomic data for this type can be found in the dataset/taxonomy - HMBA Basal Ganglia Consensus Taxonomy in cell set Group:STR D1D2 Hybrid MSN."], "t": []}], "preferred_name": "STRd D1/D2-hybrid medium spiny neuron (Primate)", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C3641687", "l": "MCPyV TAg-specific Polyclonal Autologous CD8-positive T Cells", "d": [], "t": []}, {"i": "NCIT:C104009", "l": "MCPyV TAg-specific Polyclonal Autologous CD8-positive T Cells", "d": ["A preparation of polyclonal autologous CD8 positive T-lymphocytes specific for the Merkel cell polyomavirus (MCPyV) T antigen (TAg) with potential antineoplastic activity. Peripheral blood lymphocytes from a Merkel cell carcinoma (MCC) patient were obtained and antigen-specific CD8+ T cells targeting a specific MCPyV TAg epitope were derived and expanded ex vivo. Upon infusion of the MCPyV TAg-specific polyclonal autologous CD8-positive T cell vaccine, the T cells recognize the MCPyV antigen and exert a cytotoxic T-lymphocyte response against the MCPyV TAg-expressing MCC cells. MCPyV is expressed in about 80% of MCC and is not expressed in normal, human tissue; the MCPyVTag oncoprotein plays a key role in MCC survival and tumor cell proliferation."], "t": []}], "preferred_name": "MCPyV TAg-specific Polyclonal Autologous CD8-positive T Cells", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0002265", "l": "type D cell of colon", "d": ["A D cell located in the colon."], "t": []}], "preferred_name": "type D cell of colon", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5206702", "l": "Patient-derived WT1/PRAME/Survivin-specific Cytotoxic T-lymphocytes", "d": [], "t": []}, {"i": "NCIT:C162624", "l": "Patient-derived WT1/PRAME/Survivin-specific Cytotoxic T-lymphocytes", "d": ["A preparation of autologous cytotoxic T-lymphocytes (CTLs) specifically reactive to the tumor associated antigens (TAAs) human Wilms tumor protein (WT1), preferentially expressed antigen of melanoma (PRAME, melanoma antigen preferentially expressed in tumors; Opa-interacting protein 4), and survivin (baculoviral IAP repeat-containing protein 5), with potential antineoplastic activities. Upon collection, expansion, and stimulation with antigen presenting cells pulsed with an overlapping peptide library spanning the TAAs, the multi-antigen associated CTLs are re-introduced into the patient and may induce a CTL-mediated response against tumor cells expressing WT1, PRAME, or survivin, potentially leading to tumor cell lysis and inhibition of tumor cell proliferation. WT1, PRAME, and survivin, are expressed on certain tumor cell types and play key role in tumor cell proliferation and survival."], "t": []}], "preferred_name": "Patient-derived WT1/PRAME/Survivin-specific Cytotoxic T-lymphocytes", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0333794", "l": "Abnormal cellular component of blood", "d": [], "t": []}, {"i": "SNOMEDCT:89615005", "l": "", "d": [], "t": []}], "preferred_name": "Abnormal cellular component of blood", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C2950978", "l": "Endothelial cell of endocardium for atrium", "d": [], "t": []}], "preferred_name": "Endothelial cell of endocardium for atrium", "taxa": []}
{"type": "biolink:Cell", "ic": 77.60424150429895, "identifiers": [{"i": "UMLS:C1708861", "l": "Malignant Adrenal Cortical Cell", "d": [], "t": []}, {"i": "NCIT:C48363", "l": "Malignant Adrenal Cortical Cell", "d": [], "t": []}], "preferred_name": "Malignant Adrenal Cortical Cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1267911", "l": "Lymphocyte positive for both CD34 antigen and HLA-DR antigen", "d": [], "t": []}, {"i": "SNOMEDCT:117581003", "l": "", "d": [], "t": []}], "preferred_name": "Lymphocyte positive for both CD34 antigen and HLA-DR antigen", "taxa": []}
{"type": "biolink:Cell", "ic": 56.64132914968532, "identifiers": [{"i": "CL:0000766", "l": "myeloid leukocyte", "d": ["A cell of the monocyte, granulocyte, or mast cell lineage."], "t": []}], "preferred_name": "myeloid leukocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5401389", "l": "Conditionally Reprogrammed Cells", "d": [], "t": []}, {"i": "NCIT:C172257", "l": "Conditionally Reprogrammed Cells", "d": ["A cellular sample derived from epithelial cells isolated from a tissue sample that were rapidly expanded in a monolayer culture in the presence of irradiated mouse cells and a Rho kinase (ROCK) inhibitor. Under these conditions the cells are reprogrammed to be more stem-like but the reprogramming is conditional. When the cells are transferred to cultures that mimic in vivo environments they become differentiated and can form structures that resemble the tissue from which they were derived."], "t": []}], "preferred_name": "Conditionally Reprogrammed Cells", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0814990", "l": "neural cell line", "d": [], "t": []}], "preferred_name": "neural cell line", "taxa": []}
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{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0683198", "l": "spermatosome", "d": [], "t": []}], "preferred_name": "spermatosome", "taxa": []}
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{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C0029330", "l": "Orthochromic normoblast (cell)", "d": [], "t": []}, {"i": "NCIT:C13132", "l": "Orthochromatic Erythroblast", "d": ["A cell derived from a polychromatophilic erythroblast in bone marrow. It has a dense nucleus and its cytoplasm is approaching the color of a mature erythrocyte. It differentiates into a reticulocyte when it extrudes its nucleus."], "t": []}], "preferred_name": "Orthochromic normoblast (cell)", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:1000442", "l": "urothelial cell of trigone of urinary bladder", "d": ["An urothelial cell that is part of the trigone of urinary bladder."], "t": []}, {"i": "UMLS:C1182642", "l": "Urothelial cell of trigone of urinary bladder", "d": [], "t": []}], "preferred_name": "urothelial cell of trigone of urinary bladder", "taxa": []}
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{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1258005", "l": "HCT116 Cells", "d": [], "t": []}, {"i": "MESH:D045325", "l": "HCT116 Cells", "d": [], "t": []}], "preferred_name": "HCT116 Cells", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1317187", "l": "CD10+HLA-DR+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:1373094001", "l": "", "d": [], "t": []}], "preferred_name": "CD10+HLA-DR+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5167928", "l": "HLA-DR+ cells | Blood | Cell markers", "d": [], "t": []}], "preferred_name": "HLA-DR+ cells | Blood | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5154477", "l": "Basophils | Cerebral spinal fluid | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Basophils | Cerebral spinal fluid | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5216273", "l": "Monocytes|NCnc|Pt|Body fld", "d": [], "t": []}], "preferred_name": "Monocytes|NCnc|Pt|Body fld", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5181452", "l": "S-phase cells | XXX | Molecular pathology", "d": [], "t": []}], "preferred_name": "S-phase cells | XXX | Molecular pathology", "taxa": []}
{"type": "biolink:Cell", "ic": 88.20185721311867, "identifiers": [{"i": "UMLS:C1512549", "l": "Hyperchromatic Megakaryocyte", "d": [], "t": []}, {"i": "NCIT:C37049", "l": "Hyperchromatic Megakaryocyte", "d": [], "t": []}], "preferred_name": "Hyperchromatic Megakaryocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5983704", "l": "Autologous Anti-CD5 CAR T-lymphocytes MB-105", "d": [], "t": []}, {"i": "NCIT:C211938", "l": "Autologous Anti-CD5 CAR T-lymphocytes MB-105", "d": ["A preparation of genetically modified autologous T-cells expressing a chimeric antigen receptor (CAR) directed against cluster of differentiation 5 (CD5), with potential immunomodulating and antineoplastic activities. Upon administration, the autologous anti-CD5 CAR T-lymphocytes MB-105 target and bind to CD5-expressing tumor cells, thereby inducing selective cytotoxicity in CD5-expressing tumor cells. CD5 is a T-cell surface glycoprotein expressed on the surface of normal T-cells and overexpressed on various B- and T-cell malignancies."], "t": []}], "preferred_name": "Autologous Anti-CD5 CAR T-lymphocytes MB-105", "taxa": []}
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{"type": "biolink:Cell", "ic": 92.76600187037766, "identifiers": [{"i": "CL:4042001", "l": "TAC3-positive striatal interneuron", "d": ["A GABAergic interneuron that has its soma located in the striatum and that has an enriched expression of the genes TAC3 and LHX6."], "t": []}], "preferred_name": "TAC3-positive striatal interneuron", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5220580", "l": "Erythrocytes.dysmorphic|Urine/Urine sed", "d": [], "t": []}], "preferred_name": "Erythrocytes.dysmorphic|Urine/Urine sed", "taxa": []}
{"type": "biolink:Cell", "ic": 58.833283166502575, "identifiers": [{"i": "CL:0000138", "l": "chondrocyte", "d": ["A skeletogenic cell that secretes a specialized, avascular, GAG-rich matrix, is embedded in cartilage tissue matrix, retains the ability to divide, and develops from a chondroblast cell."], "t": []}], "preferred_name": "chondrocyte", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5173493", "l": "Mononuclear cells | Body fluid | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Mononuclear cells | Body fluid | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1545463", "l": "CD3+CD56+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:1373012001", "l": "", "d": [], "t": []}], "preferred_name": "CD3+CD56+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1511470", "l": "CY92", "d": [], "t": []}, {"i": "NCIT:C20244", "l": "CY92", "d": ["Provider: CyThera, Inc., San Diego, CA. No information from provider. This cell line meets the criteria for the use of human embryonic stem cells by federally funded researchers."], "t": []}], "preferred_name": "CY92", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1317191", "l": "CD227+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:1372864001", "l": "", "d": [], "t": []}], "preferred_name": "CD227+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4023116", "l": "type 2 spiral ganglion neuron", "d": ["A spiral ganglion neuron that innervates outer hair cells. Type 1 spiral ganglion neurons are unmyelinated and unipolar."], "t": []}], "preferred_name": "type 2 spiral ganglion neuron", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5909067", "l": "Tacatresgene Autoleucel", "d": [], "t": []}, {"i": "NCIT:C203190", "l": "Tacatresgene Autoleucel", "d": [], "t": []}], "preferred_name": "Tacatresgene Autoleucel", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C4763664", "l": "CD56-enriched CD3-positive Donor Lymphocytes", "d": [], "t": []}, {"i": "NCIT:C157500", "l": "CD56-enriched CD3-positive Donor Lymphocytes", "d": ["A population of CD3-positive lymphocytes expressing the CD56 surface antigen, with potential immunomodulating activity. Upon infusion of the CD56-enriched CD3-positive donor lymphocytes, these cells may facilitate the reconstitution of CD4-positive T-cells, regulatory T-cells (Tregs) and natural killer (NK) cells, which may reduce the incidence of post-transplant graft-versus-host disease (GvHD) following haploidentical stem cell transplant (SCT). CD56 is a transmembrane glycoprotein also known as neural cell adhesion molecule 1 (NCAM-1)."], "t": []}], "preferred_name": "CD56-enriched CD3-positive Donor Lymphocytes", "taxa": []}
{"type": "biolink:Cell", "ic": 64.45488614229991, "identifiers": [{"i": "UMLS:C1513960", "l": "Neoplastic Epithelial Clear Cell", "d": [], "t": []}, {"i": "NCIT:C36756", "l": "Neoplastic Epithelial Clear Cell", "d": [], "t": []}], "preferred_name": "Neoplastic Epithelial Clear Cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0598613", "l": "HTC cell", "d": [], "t": []}], "preferred_name": "HTC cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1317558", "l": "Agranular neutrophil", "d": [], "t": []}, {"i": "SNOMEDCT:726589001", "l": "", "d": [], "t": []}], "preferred_name": "Agranular neutrophil", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5154482", "l": "Basophils | Pleural fluid | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Basophils | Pleural fluid | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5161798", "l": "Cytoplasmic CD22 blasts | Blood | Cell markers", "d": [], "t": []}], "preferred_name": "Cytoplasmic CD22 blasts | Blood | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4310146", "l": "AMY-SLEA-BNST GABA GABAergic interneuron (Primate)", "d": ["A GABAergic interneuron of the Primates brain. These cells are located in the striatum . Reference transcriptomic data for this type can be found in the dataset/taxonomy - HMBA Basal Ganglia Consensus Taxonomy in cell set Group:AMY-SLEA-BNST GABA."], "t": []}], "preferred_name": "AMY-SLEA-BNST GABA GABAergic interneuron (Primate)", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4072016", "l": "NPY interneuron", "d": ["An interneuron that expresses neuropeptide Y (NPY) and is mainly located in cortical layers II–III and VI, as well as in various brain regions such as the medial geniculate and inferior colliculus. The NPY cell population is physiologically diverse, displaying a range of firing behaviors, including adapting, fast-spiking, and accelerating patterns."], "t": []}], "preferred_name": "NPY interneuron", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C2332462", "l": "Basket cell of cerebral cortex", "d": [], "t": []}], "preferred_name": "Basket cell of cerebral cortex", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0000497", "l": "red sensitive photoreceptor cell", "d": ["A photoreceptor cell that is sensitive to red light."], "t": []}], "preferred_name": "red sensitive photoreceptor cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0020020", "l": "homeostatic chondrocyte", "d": ["A chondrocyte identified in both healthy and osteoarthritic human articular cartilage, and in intervertebral disc tissue. In healthy articular cartilage, a homeostatic chondrocyte is characterised by the expression of TXNIP, IFITM3, GDF15, and TIMP1 (Wang et al., 2021), among other extracellular matrix and regulatory molecules. This cell maintains cartilage integrity by producing key ECM components and supporting baseline tissue homeostasis. In OA cartilage, this cell is enriched for genes related to cellular homeostasis modulation, including regulation of the cell cycle, development, and RNA metabolism (Ji et al., 2018)."], "t": []}], "preferred_name": "homeostatic chondrocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5237427", "l": "Autologous CD34-positive Peripheral Blood Stem Cells", "d": [], "t": []}, {"i": "NCIT:C165750", "l": "Autologous CD34-positive Peripheral Blood Stem Cells", "d": ["A population of autologous cluster of differentiation 34 (CD34)-positive peripheral blood stem cells (PBSCs) that can be used for autologous hematopoietic stem cell transplantation (AHSCT). Upon mobilization and collection of the autologous CD34+ PBSCs by leukapheresis, the CD34+ PBSCs are re-infused into the patient. Upon transplantation, these cells can differentiate into a variety of cell types including the formation of new hematopoietic and immune cells."], "t": []}], "preferred_name": "Autologous CD34-positive Peripheral Blood Stem Cells", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0010013", "l": "type I pinealocyte", "d": [], "t": []}], "preferred_name": "type I pinealocyte", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5157516", "l": "CD3-CD16+ cells | Body fluid | Cell markers", "d": [], "t": []}], "preferred_name": "CD3-CD16+ cells | Body fluid | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4033013", "l": "suprabasal keratinocyte", "d": ["A keratinocyte that resides in the epidermal suprabasal layer and expresses differentiation markers, including keratin 1 and keratin 10, in both humans and mice. In human interfollicular epidermis, this cell retains proliferative capacity and possesses retrodifferentiation potential, acquiring basal-like properties during wound healing or basement membrane contact."], "t": []}], "preferred_name": "suprabasal keratinocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "CL:0000106", "l": "unipolar neuron", "d": ["Neuron with one neurite that extends from the cell body."], "t": []}, {"i": "UMLS:C1519793", "l": "Unipolar neuron", "d": [], "t": []}, {"i": "NCIT:C33834", "l": "Unipolar Neuron", "d": ["A conducting cell of the nervous system that has only one process extending from the cell body. It is always a sensory neuron."], "t": []}], "preferred_name": "unipolar neuron", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5907955", "l": "Autologous Anti-CD19 CAR T Cells KITE-197", "d": [], "t": []}, {"i": "NCIT:C202233", "l": "Autologous Anti-CD19 CAR T Cells KITE-197", "d": ["A preparation of autologous T-lymphocytes that have been genetically engineered to express a chimeric antigen receptor (CAR) specific for the tumor-associated antigen (TAA) CD19, with potential immunomodulating and antineoplastic activities. Upon administration, autologous anti-CD19 CAR T-cells KITE-197 specifically recognize and kill tumor cells expressing CD19. CD19 antigen is a B-cell specific cell surface antigen expressed in all B-cell lineage malignancies."], "t": []}], "preferred_name": "Autologous Anti-CD19 CAR T Cells KITE-197", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5853632", "l": "CLL1-CD33 compound chimeric antigen receptor T cells", "d": [], "t": []}], "preferred_name": "CLL1-CD33 compound chimeric antigen receptor T cells", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5399350", "l": "Tecartus", "d": [], "t": []}], "preferred_name": "Tecartus", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0521182", "l": "Opalski cell", "d": [], "t": []}, {"i": "SNOMEDCT:83687003", "l": "", "d": [], "t": []}], "preferred_name": "Opalski cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5966209", "l": "ADP-A2M4", "d": [], "t": []}], "preferred_name": "ADP-A2M4", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C6021983", "l": "Leukocytes | Pus | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Leukocytes | Pus | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": 82.62268137420203, "identifiers": [{"i": "UMLS:C0229657", "l": "Plasmablast (cell)", "d": [], "t": []}, {"i": "NCIT:C37082", "l": "Plasmablast", "d": ["A population of antibody-secreting cells in the blood that are highly proliferative and may act as precursors for plasma cells."], "t": []}, {"i": "SNOMEDCT:2579009", "l": "", "d": [], "t": []}], "preferred_name": "Plasmablast (cell)", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4033090", "l": "atretic granulosa cell", "d": ["A granulosa cell that is undergoing atresia. This cell type displays distinct morphological alterations compared with a healthy granulosa cell, including pyknosis (nuclear condensation) and cellular shrinkage."], "t": []}], "preferred_name": "atretic granulosa cell", "taxa": []}
{"type": "biolink:Cell", "ic": 81.743421370964, "identifiers": [{"i": "CL:1000891", "l": "kidney arterial blood vessel cell", "d": ["Any kidney blood vessel cell that is part of some kidney arterial blood vessel."], "t": []}], "preferred_name": "kidney arterial blood vessel cell", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "CL:4023048", "l": "L4/5 intratelencephalic projecting glutamatergic neuron of the primary motor cortex", "d": ["An intratelencephalic-projecting glutamatergic with a soma located in upper L5 of the primary motor cortex. These cells have thin untufted apical dendrites."], "t": []}], "preferred_name": "L4/5 intratelencephalic projecting glutamatergic neuron of the primary motor cortex", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "CL:0000847", "l": "ciliated olfactory receptor neuron", "d": ["An olfactory receptor cell in which the apical ending of the dendrite is a pronounced ciliated olfactory knob."], "t": []}], "preferred_name": "ciliated olfactory receptor neuron", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "CL:0002314", "l": "external supporting cell of vestibular epithelium", "d": ["An auditory epithelial support cell located in the vestibular epithelium that has many hallmarks of glial cells. This cell type express glial markers such as vimentin, S100, glutamate-aspartate transporter, low affinity neurotrophin receptor p75, glial fibrillary acidic protein, and proteolipid protein."], "t": []}, {"i": "UMLS:C0229473", "l": "Cell of Claudius", "d": [], "t": []}, {"i": "NCIT:C12478", "l": "Clear Cell", "d": ["A cell with empty-appearing cytoplasm when viewed with a light microscope."], "t": []}, {"i": "SNOMEDCT:40489007", "l": "", "d": [], "t": []}], "preferred_name": "external supporting cell of vestibular epithelium", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0000496", "l": "green sensitive photoreceptor cell", "d": ["A photoreceptor cell that is sensitive to green light."], "t": []}], "preferred_name": "green sensitive photoreceptor cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0022827", "l": "L Cells", "d": [], "t": []}, {"i": "MESH:D007739", "l": "L Cells", "d": [], "t": []}], "preferred_name": "L Cells", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C2348032", "l": "Cytokine-Induced Killer Cells", "d": [], "t": []}, {"i": "NCIT:C71757", "l": "Cytokine-Induced Killer Cells", "d": ["A preparation of cytokine-induced killer (CIK) cells, with potential immunopotentiating and antineoplastic activities. CIK cells are generated from peripheral blood lymphocytes (PBLs) by sequential ex vivo incubation with a monoclonal antibody against CD3 (anti-CD3), interferon-gamma (IFN-g) and interleukin-2 (IL-2), followed by expansion. CIK cells are heterogeneous cells comprising CD3+CD56- T cells, CD3-CD56+ natural killer (NK) cells, and CD3+CD56+ natural killer T (NKT) cells. Upon administration of the CIK cells into the patient, the terminally differentiated CD3- and CD56-positive subset of the CIK cells primarily exert the direct MHC-unrestricted tumor killing activity."], "t": []}, {"i": "MESH:D055612", "l": "Cytokine-Induced Killer Cells", "d": [], "t": []}], "preferred_name": "Cytokine-Induced Killer Cells", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5958839", "l": "Autologous Anti-BCMA-CAR-4-1BB-expressing T-cells NXC-201", "d": [], "t": []}], "preferred_name": "Autologous Anti-BCMA-CAR-4-1BB-expressing T-cells NXC-201", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1267885", "l": "Lymphoblast positive for CD19 antigen", "d": [], "t": []}, {"i": "SNOMEDCT:117562006", "l": "", "d": [], "t": []}], "preferred_name": "Lymphoblast positive for CD19 antigen", "taxa": []}
{"type": "biolink:Cell", "ic": 83.11065783093733, "identifiers": [{"i": "CL:0002257", "l": "epithelial cell of thyroid gland", "d": ["An epithelial cell of thyroid gland."], "t": []}], "preferred_name": "epithelial cell of thyroid gland", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4072005", "l": "A8 dopaminergic neuron", "d": ["A type of midbrain dopaminergic neuron localized in the retrorubral field which projects to limbic and cortical regions involved in emotion, motivation, and reward."], "t": []}], "preferred_name": "A8 dopaminergic neuron", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1440142", "l": "Blasts.CD14", "d": [], "t": []}], "preferred_name": "Blasts.CD14", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C4289953", "l": "Autologous CD34-positive Hematopoietic Progenitor Cells", "d": [], "t": []}, {"i": "NCIT:C128249", "l": "Autologous CD34-positive Hematopoietic Progenitor Cells", "d": ["A population of autologous CD34-positive hematopoietic progenitor cells (HPCs) that can be used for autotransplantation. CD34+ HPCs are isolated from human blood stem cells upon apheresis. Upon transplantation with the CD34+ HPCs, these cells can differentiate into a variety of cell types including fibroblasts, osteoblasts, chondrocytes, myocytes, adipocytes, and endothelial cells."], "t": []}], "preferred_name": "Autologous CD34-positive Hematopoietic Progenitor Cells", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0017011", "l": "hillock cell of prostatic urethral epithelium", "d": ["A hillock cell that is part of the prostatic urethra."], "t": []}], "preferred_name": "hillock cell of prostatic urethral epithelium", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5168982", "l": "Immature monocytes | Blood | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Immature monocytes | Blood | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4310094", "l": "prototypic neuron (Primate)", "d": ["A prototypic neuron of the Primates brain. These cells are located in the striatum, external segment of globus pallidus . Reference transcriptomic data for this type can be found in the dataset/taxonomy - HMBA Basal Ganglia Consensus Taxonomy in cell set Group:GPe SOX6-CTXND1 GABA."], "t": []}], "preferred_name": "prototypic neuron (Primate)", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C0443779", "l": "Microspherocyte", "d": [], "t": []}, {"i": "NCIT:C206384", "l": "Microspherocyte", "d": ["Spherocytes that result from red cell fragmentation or from removal of a considerable proportion of the red cell membrane by splenic or other macrophages."], "t": []}, {"i": "SNOMEDCT:259683003", "l": "", "d": [], "t": []}], "preferred_name": "Microspherocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 53.33617738290166, "identifiers": [{"i": "CL:0000499", "l": "stromal cell", "d": ["A connective tissue cell of an organ found in the loose connective tissue."], "t": []}, {"i": "UMLS:C0162597", "l": "Stromal Cells", "d": [], "t": []}, {"i": "NCIT:C12571", "l": "Stromal Cell", "d": ["Connective tissue cells found in the tissue stroma of any organ."], "t": []}, {"i": "MESH:D017154", "l": "Stromal Cells", "d": [], "t": []}], "preferred_name": "stromal cell", "taxa": []}
{"type": "biolink:Cell", "ic": 80.27409497666227, "identifiers": [{"i": "CL:0000995", "l": "CD34-positive, CD38-positive common myeloid progenitor OR CD34-positive, CD38-positive common lymphoid progenitor", "d": [], "t": []}], "preferred_name": "CD34-positive, CD38-positive common myeloid progenitor OR CD34-positive, CD38-positive common lymphoid progenitor", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:1001224", "l": "interlobulary vein smooth muscle cell", "d": ["Any smooth muscle cell that is part of some renal interlobular vein."], "t": []}], "preferred_name": "interlobulary vein smooth muscle cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5554962", "l": "LMP2-specific IL-12 Secreting T Cell Receptor-transduced T-lymphocytes", "d": [], "t": []}, {"i": "NCIT:C178337", "l": "LMP2-specific IL-12 Secreting T Cell Receptor-transduced T-lymphocytes", "d": ["A preparation of T-lymphocytes that have been genetically modified to encode a T-cell receptor (TCR) specific for Epstein-Barr virus (EBV) latent membrane protein (LMP) 2, with potential antineoplastic activity. Upon administration, the LMP2-specific IL-12 secreting TCR-transduced T-lymphocytes (TCR-T) recognize and bind to EBV LMP2, which may promote cell death and inhibit the growth of tumor cells expressing LMP2. In addition, IL-12 expression activates the immune system by promoting the secretion of interferon-gamma, activating natural killer cells (NKs), and inducing cytotoxic T-cell responses, which may result in both decreased cell proliferation and increased cell death in LMP2-expressing tumor cells. As a tumor associated antigen (TAA), LMP2 is expressed in various EBV-associated malignancies including nasopharyngeal cancer and EBV-positive Hodgkin lymphoma."], "t": []}], "preferred_name": "LMP2-specific IL-12 Secreting T Cell Receptor-transduced T-lymphocytes", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:1000329", "l": "tracheal goblet cell", "d": ["A goblet cell that is part of the epithelium of trachea."], "t": []}, {"i": "UMLS:C2334670", "l": "Tracheal goblet cell", "d": [], "t": []}], "preferred_name": "tracheal goblet cell", "taxa": []}
{"type": "biolink:Cell", "ic": 81.743421370964, "identifiers": [{"i": "CL:0000599", "l": "conidium", "d": ["An asexual, nonmotile spore formed by higher fungi; conidia are usually made from the side or tip of specialized sporogenous cells and do not form by progressive cleavage of the cytoplasm."], "t": []}], "preferred_name": "conidium", "taxa": []}
{"type": "biolink:Cell", "ic": 90.871710685482, "identifiers": [{"i": "UMLS:C1511245", "l": "Bone Marrow Stem Cell with Predominant Neutrophil Differentiation", "d": [], "t": []}, {"i": "NCIT:C41060", "l": "Bone Marrow Stem Cell with Predominant Neutrophil Differentiation", "d": ["A primitive, undifferentiated blood cell which can undergo division and usually gives rise to a white blood cell in the neutrophil lineage."], "t": []}], "preferred_name": "Bone Marrow Stem Cell with Predominant Neutrophil Differentiation", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0229642", "l": "Eosinophilic myelocyte", "d": [], "t": []}, {"i": "SNOMEDCT:90961003", "l": "", "d": [], "t": []}], "preferred_name": "Eosinophilic myelocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 73.04009684703995, "identifiers": [{"i": "CL:0000038", "l": "erythroid progenitor cell", "d": ["A progenitor cell committed to the erythroid lineage."], "t": []}], "preferred_name": "erythroid progenitor cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0427532", "l": "Hypergranular white blood cell", "d": [], "t": []}, {"i": "SNOMEDCT:250291005", "l": "", "d": [], "t": []}], "preferred_name": "Hypergranular white blood cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5560996", "l": "Allogeneic cultured keratinocytes and fibroblasts in bovine collagen", "d": [], "t": []}], "preferred_name": "Allogeneic cultured keratinocytes and fibroblasts in bovine collagen", "taxa": []}
{"type": "biolink:Cell", "ic": 90.871710685482, "identifiers": [{"i": "CL:0002228", "l": "primary lens fiber", "d": ["An elongating cell that rapidly obliterates the lumen of the lens vesicle. Subsequently, differentiation of this cell type at the lens equator leads to the formation of secondary fiber cells that come to overlie the primary fibers."], "t": []}, {"i": "UMLS:C1182653", "l": "Primary lens fiber", "d": [], "t": []}], "preferred_name": "primary lens fiber", "taxa": []}
{"type": "biolink:Cell", "ic": 72.31349143091559, "identifiers": [{"i": "CL:0000463", "l": "epidermal cell (sensu Arthropoda)", "d": ["An epidermal cell that secretes chitinous cuticle from its apical side."], "t": []}], "preferred_name": "epidermal cell (sensu Arthropoda)", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0009093", "l": "smooth muscle cell of placenta", "d": ["A smooth muscle cell that is part of a placenta."], "t": []}], "preferred_name": "smooth muscle cell of placenta", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C2324195", "l": "Cone bipolar cell", "d": [], "t": []}], "preferred_name": "Cone bipolar cell", "taxa": []}
{"type": "biolink:Cell", "ic": 92.76600187037766, "identifiers": [{"i": "CL:0000580", "l": "neutrophilic myelocyte", "d": ["A neutrophil precursor in the granulocytic series, being a cell intermediate in development between a promyelocyte and a metamyelocyte; in this stage, production of primary granules is complete and neutrophil-specific granules has started. No nucleolus is present. This cell type is CD13-positive, CD16-negative, integrin alpha-M-positive, CD15-positive, CD33-positive, CD24-positive, C/EBP-a-positive, C/EBPe-positive, PU.1-positive, lactotransferrin-positive, myeloperoxidase-positive and NGAL-positive."], "t": []}], "preferred_name": "neutrophilic myelocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 54.25013512271183, "identifiers": [{"i": "UMLS:C1514044", "l": "Neoplastic Neuroendocrine Cell", "d": [], "t": []}, {"i": "NCIT:C36761", "l": "Neoplastic Neuroendocrine Cell", "d": [], "t": []}], "preferred_name": "Neoplastic Neuroendocrine Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5908018", "l": "Autologous Anti-CD19 CAR-T Cells CABA-201", "d": [], "t": []}, {"i": "NCIT:C203740", "l": "Autologous Anti-CD19 CAR-T Cells CABA-201", "d": ["A preparation of autologous T-lymphocytes that have been genetically modified to express a chimeric antigen receptor (CAR) specific for the B-lymphocyte antigen CD19, coupled to a costimulatory domain of 4-1BB (CD137), with potential immunomodulatory activity. Upon administration, autologous anti-CD19 CAR-T cells CABA-201 target and bind to CD19-expressing B-cells. This results in a cytotoxic T-lymphocyte (CTL) response against CD19-expressing B-cells. CD19, a B-cell-specific cell surface antigen that plays an important role in B-cell activation, is overexpressed in some autoimmune diseases."], "t": []}], "preferred_name": "Autologous Anti-CD19 CAR-T Cells CABA-201", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C4724406", "l": "Anti-minor Histocompatibility Complex Donor T-Lymphocytes", "d": [], "t": []}, {"i": "NCIT:C148500", "l": "Anti-minor Histocompatibility Complex Donor T-Lymphocytes", "d": ["A preparation of allogeneic, donor-derived T-lymphocytes that are specific for a unique set of minor histocompatibility complex antigens (MiHA) exclusively found on the surface of malignant cells, with potential immunomodulating and antineoplastic activities. T-lymphocytes are derived from an allogeneic hematopoietic cell transplant (AHCT) donor. Ex vivo, these T-cells are exposed to and primed against a select set of host-specific hematopoietic tissue-restricted MiHAs that are expressed on leukemic cells. Then the cells are subsequently expanded. After AHCT and infusion of the anti-MiHA T-lymphocytes, these cells target and bind to MiHA antigens expressed on the host's leukemia cells, thereby killing these cancer cells. MiHA are small, cell-surface peptides that are associated with graft-versus-host disease (GvHD). The selected set of MiHAs is expressed mainly, or only, by hematopoietic cells, and overexpressed on leukemic cells."], "t": []}], "preferred_name": "Anti-minor Histocompatibility Complex Donor T-Lymphocytes", "taxa": []}
{"type": "biolink:Cell", "ic": 92.76600187037766, "identifiers": [{"i": "CL:0000633", "l": "Hensen cell", "d": ["A tall supporting cell that is arranged in rows adjacent to the last row of outer phalangeal cells. This cell type constitutes the outer border of the organ of Corti."], "t": []}, {"i": "UMLS:C0229472", "l": "Cell of Hensen", "d": [], "t": []}, {"i": "SNOMEDCT:57870006", "l": "", "d": [], "t": []}], "preferred_name": "Hensen cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0312865", "l": "Sensitized red cell", "d": [], "t": []}, {"i": "SNOMEDCT:57722009", "l": "", "d": [], "t": []}], "preferred_name": "Sensitized red cell", "taxa": []}
{"type": "biolink:Cell", "ic": 92.76600187037766, "identifiers": [{"i": "CL:0002080", "l": "pancreatic centro-acinar cell", "d": ["A cubodial epithelial cell that is continuous with the lining of intercalated ducts that drain the acinus. This cell type secretes a high pH solution to aid in activation of zymogens, and can differentiate into endocrine and exocrine pancreatic cell types."], "t": []}, {"i": "UMLS:C1179160", "l": "Pancreatic centro-acinar cell", "d": [], "t": []}, {"i": "NCIT:C33254", "l": "Pancreatic Centroacinar Cell", "d": ["A cell with a centrally placed nucleus found in the proximal portion of pancreatic intercalated duct that protrudes into the acinus. It secretes bicarbonate made in the cell by the dissociation of carbonic acid in the presence of carbonic anhydrase II. These cells are thought to act as signal transducers, influencing the degranulation of the acinar cells."], "t": []}], "preferred_name": "pancreatic centro-acinar cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5669570", "l": "Etuvetidigene Autotemcel", "d": [], "t": []}, {"i": "NCIT:C184832", "l": "Etuvetidigene Autotemcel", "d": [], "t": []}], "preferred_name": "Etuvetidigene Autotemcel", "taxa": []}
{"type": "biolink:Cell", "ic": 63.41012728548574, "identifiers": [{"i": "UMLS:C1711355", "l": "Malignant Neuroectodermal Cell", "d": [], "t": []}, {"i": "NCIT:C53987", "l": "Malignant Neuroectodermal Cell", "d": [], "t": []}], "preferred_name": "Malignant Neuroectodermal Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 67.8984399852903, "identifiers": [{"i": "CL:0001065", "l": "innate lymphoid cell", "d": ["A lymphocyte that lacks characteristic T cell, B cell, myeloid cell, and dendritic cell markers, that functions as part of the innate immune response to produce cytokines and other effector responses."], "t": []}], "preferred_name": "innate lymphoid cell", "taxa": []}
{"type": "biolink:Cell", "ic": 54.614237202057225, "identifiers": [{"i": "CL:0000837", "l": "hematopoietic multipotent progenitor cell", "d": ["A hematopoietic multipotent progenitor cell is multipotent, but not capable of long-term self-renewal. These cells are characterized as lacking lineage cell surface markers and being CD34-positive in both mice and humans."], "t": []}], "preferred_name": "hematopoietic multipotent progenitor cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0887811", "l": "Radiation Hybrids", "d": [], "t": []}], "preferred_name": "Radiation Hybrids", "taxa": []}
{"type": "biolink:Cell", "ic": 71.74874531021723, "identifiers": [{"i": "UMLS:C1709161", "l": "Neoplastic Adenohypophysial Cell", "d": [], "t": []}, {"i": "NCIT:C45963", "l": "Neoplastic Adenohypophysial Cell", "d": [], "t": []}], "preferred_name": "Neoplastic Adenohypophysial Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C4527256", "l": "Allogeneic CD3- CD19- CD57+ NKG2C+ NK Cells FATE-NK100", "d": [], "t": []}, {"i": "NCIT:C137863", "l": "Allogeneic CD3- CD19- CD57+ NKG2C+ NK Cells FATE-NK100", "d": ["A preparation of pharmacologically-enriched, allogeneic natural killer (NK) cells derived from a related but not completely matched human leukocyte antigen (HLA)-haploidentical donor that is seropositive for cytomegalovirus (CMV+), with potential cytolytic and antineoplastic activities. Upon leukapheresis, the donor peripheral blood mononuclear cells (PBMCs) are treated to remove T-lymphocytes (CD3+) and B-lymphocytes (CD19+). The remaining leukocytes are cultured for 7 days with the cytokine interleukin-15 (IL-15) and a small molecule inhibitor of glycogen synthase kinase 3-beta (GSK3beta) to generate the adaptive, CD3- CD19- CD57+ NKG2C+ NK cells FATE-NK100 ex vivo. Upon infusion of the allogeneic CD3- CD19- CD57+ NKG2C+ NK cells FATE-NK100, these cells selectively recognize and bind to tumor cells, and secrete perforins, granzymes, and cytokines, which results in cancer cell lysis. Exposure to CMV induces the expression of the memory-like activating receptor NKG2C and the maturation marker CD57 in the isolated NK cells, making them more potent than those not pre-exposed to CMV. CD57 both enhances the effector function of NK cells and stimulates CD16-dependent signaling. Treatment with IL-15 enhances NK cell proliferation and survival. The GSK3beta inhibitor induces preferential expansion of CD57+ NK cells that exhibit enhanced interferon (IFN)-gamma production."], "t": []}], "preferred_name": "Allogeneic CD3- CD19- CD57+ NKG2C+ NK Cells FATE-NK100", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5421268", "l": "Autologous Nectin-4/FAP-targeted CAR-T Cells", "d": [], "t": []}, {"i": "NCIT:C172386", "l": "Autologous Nectin-4/FAP-targeted CAR-T Cells", "d": ["A preparation of autologous T-lymphocytes engineered to express a chimeric antigen receptor (CAR) specific for the tumor-associated antigen (TAA) nectin-4 and cell surface protein fibroblast activation protein (FAP), and additionally an inducible expression cassette encoding transgenic interleukin (IL) 7 (IL-7) or 12 (IL-12), with potential immunostimulating and antineoplastic activities. Upon intratumoral administration, the autologous nectin-4/FAP-targeted CAR-T cells target and bind to nectin-4-expressing tumor cells and FAP-expressing cancer associated fibroblasts (CAFs). This results in a cytotoxic T-lymphocyte (CTL) response against nectin-4-expressing tumor cells and FAP-expressing CAFs, leading to cell lysis of these cells. Upon the binding to nectin-4 and FAP and the activation of the CAR-T cells, cytokine IL-7 or IL-12 is also released. This further augments the immune responses against the tumor cells, which may include the attack of nectin-4-negative tumor cells by tumor necrosis factor alpha (TNFa). Nectin-4, a TAA belonging to the nectin family, is overexpressed in a variety of cancers, including breast, bladder, lung and pancreatic cancer. FAP, a cell surface glycoprotein, is overexpressed on CAFs but minimally expressed on normal, healthy cells."], "t": []}], "preferred_name": "Autologous Nectin-4/FAP-targeted CAR-T Cells", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1267934", "l": "Lymphocyte positive for CD47 antigen", "d": [], "t": []}, {"i": "SNOMEDCT:117377002", "l": "", "d": [], "t": []}], "preferred_name": "Lymphocyte positive for CD47 antigen", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4042016", "l": "nasal serous secreting cell", "d": ["A serous secreting cell that is part of a submucosal gland in the nasal cavity respiratory epithelium."], "t": []}], "preferred_name": "nasal serous secreting cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5171663", "l": "Lymphocytes | Pericardial fluid | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Lymphocytes | Pericardial fluid | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:1001590", "l": "epididymis secretory cell", "d": ["Glandular cell of epididymal epithelium."], "t": []}], "preferred_name": "epididymis secretory cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5983499", "l": "Senacnagene Enfaleucel", "d": [], "t": []}, {"i": "NCIT:C211714", "l": "Senacnagene Enfaleucel", "d": [], "t": []}], "preferred_name": "Senacnagene Enfaleucel", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1514182", "l": "Mesothelial cell of pleura", "d": [], "t": []}, {"i": "NCIT:C33330", "l": "Pleural Mesothelial Cell", "d": [], "t": []}], "preferred_name": "Mesothelial cell of pleura", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1267998", "l": "Lymphocyte positive for CD120A antigen", "d": [], "t": []}, {"i": "SNOMEDCT:117438004", "l": "", "d": [], "t": []}], "preferred_name": "Lymphocyte positive for CD120A antigen", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0002554", "l": "fibroblast of lymphatic vessel", "d": ["A fibroblast of the lymphatic system."], "t": []}], "preferred_name": "fibroblast of lymphatic vessel", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C4733642", "l": "Autologous Anti-HLA-A*0201/AFP CAR T-cells ET1402L1", "d": [], "t": []}, {"i": "NCIT:C155884", "l": "Autologous Anti-HLA-A*0201/AFP CAR T-cells ET1402L1", "d": ["A preparation of autologous T-lymphocytes that have been transduced with a lentiviral vector encoding a chimeric antigen receptor (CAR) containing a single chain variable fragment (scFv) derived from a human monoclonal antibody specific for an immunogenic human tumor-associated antigen (TAA) alpha-fetoprotein (AFP) epitope, AFP158-166, complexed with human leukocyte antigen (HLA)-A*02:01 (HLA-A*0201/AFP), fused to the co-stimulatory domains of CD28 and CD3zeta, with potential immunostimulating and antineoplastic activities. Upon administration, the autologous anti-HLA-A*0201/AFP CAR T-cells ET1402L1 specifically recognize and selectively bind to the AFP158-166 peptide presented by HLA-A*0201. Upon binding to the AFP-MHC complex, the T-cells release cytokines and induce selective toxicity in HLA-A*0201/AFP-positive tumor cells. AFP, an intracellularly expressed fetal glycoprotein rarely expressed in adult tissues, is overexpressed in certain tumors of endodermal origin and plays a key role in tumor cell proliferation and survival. AFP is processed into peptides and presented by class I major histocompatibility complexes (MHCs) on the surface of tumor cells."], "t": []}], "preferred_name": "Autologous Anti-HLA-A*0201/AFP CAR T-cells ET1402L1", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5216202", "l": "Eosinophils|NCnc|Pt|Pericard fld", "d": [], "t": []}], "preferred_name": "Eosinophils|NCnc|Pt|Pericard fld", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0682613", "l": "hepatocyte structure", "d": [], "t": []}], "preferred_name": "hepatocyte structure", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5454449", "l": "Nucleated erythrocytes | Blood cord | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Nucleated erythrocytes | Blood cord | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5163551", "l": "Epithelial cells.parabasal | Vaginal | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Epithelial cells.parabasal | Vaginal | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0000257", "l": "Eumycetozoan cell", "d": ["Any cell that in taxon some Eumycetozoa."], "t": []}], "preferred_name": "Eumycetozoan cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:1000467", "l": "chromaffin cell of left ovary", "d": ["A chromaffin cell that is part of the left ovary."], "t": []}, {"i": "UMLS:C1183982", "l": "Chromaffin cell of left ovary", "d": [], "t": []}], "preferred_name": "chromaffin cell of left ovary", "taxa": []}
{"type": "biolink:Cell", "ic": 81.34422831136257, "identifiers": [{"i": "UMLS:C1519112", "l": "Round Striated Muscle Cell", "d": [], "t": []}, {"i": "NCIT:C36950", "l": "Round Striated Muscle Cell", "d": [], "t": []}], "preferred_name": "Round Striated Muscle Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 74.24062392510156, "identifiers": [{"i": "CL:0000390", "l": "blood cell (sensu Nematoda and Protostomia)", "d": [], "t": []}], "preferred_name": "blood cell (sensu Nematoda and Protostomia)", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0882828", "l": "CD3+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:116744006", "l": "", "d": [], "t": []}], "preferred_name": "CD3+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": 92.76600187037766, "identifiers": [{"i": "CL:0005011", "l": "renal alpha-intercalated cell", "d": ["A cuboidal epithelial cell of the kidney which secretes acid and reabsorbs base to regulate acid/base balance."], "t": []}], "preferred_name": "renal alpha-intercalated cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4033163", "l": "myenteric ganglion of small intestine nNOS/VIP neuron", "d": ["An enteric neuron that has the soma located in the myenteric ganglion of the small intestine and expresses the marker neuronal nitric oxide synthase 1 (nNOS) and vasoactive intestinal peptide (VIP)."], "t": []}], "preferred_name": "myenteric ganglion of small intestine nNOS/VIP neuron", "taxa": []}
{"type": "biolink:Cell", "ic": 41.946869469297354, "identifiers": [{"i": "UMLS:C1514033", "l": "Neoplastic Muscle Cell", "d": [], "t": []}, {"i": "NCIT:C36936", "l": "Neoplastic Muscle Cell", "d": ["A neoplastic mesenchymal cell that originates from a myocyte."], "t": []}], "preferred_name": "Neoplastic Muscle Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0001081", "l": "group 2 innate lymphoid cell, human", "d": ["A group 2 innate lymphoid cell in the human with the phenotype CD25-positive, CD127-positive, CD161-positive, and GATA-3-positive."], "t": []}], "preferred_name": "group 2 innate lymphoid cell, human", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1267828", "l": "T lymphocyte positive for both CD8 antigen and CD11b antigen", "d": [], "t": []}, {"i": "SNOMEDCT:115414002", "l": "", "d": [], "t": []}], "preferred_name": "T lymphocyte positive for both CD8 antigen and CD11b antigen", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5670964", "l": "Autologous PBMC-derived Engineered Leukocyte Immunostimulatory Cells-activated Effector Cells", "d": [], "t": []}], "preferred_name": "Autologous PBMC-derived Engineered Leukocyte Immunostimulatory Cells-activated Effector Cells", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5706479", "l": "Anti-FOLR1 CoStAR-expressing Autologous Tumor-infiltrating Lymphocytes ITIL-306", "d": [], "t": []}, {"i": "NCIT:C188248", "l": "Anti-FOLR1 CoStAR-expressing Autologous Tumor-infiltrating Lymphocytes ITIL-306", "d": ["A preparation of autologous tumor infiltrating lymphocytes (TILs) genetically engineered to express a co-stimulatory antigen receptor (CoStAR) specific for folate receptor alpha (FolRa; FOLR1) and linked to the co-stimulatory domains CD28 and CD40, with potential immunomodulating and antineoplastic activities. Upon administration, the anti-FOLR1 CoStAR-expressing autologous TILs ITIL-306 specifically target, bind to and kill the FOLR1-expressing tumor cells. In addition, ITIL-306, by binding to FOLR1, is able to activate the TILs through the costimulatory signals. This increases T-cell proliferation and activation in the tumor microenvironment (TME), thereby enhancing the T-cell-mediated anti-tumor immune response against the FOLR1-expressing tumor cells. FOLR1 is a glycosylphosphatidylinositol linked cell-surface glycoprotein that is widely expressed in certain cancers while its expression is limited in normal tissues. CoStAR provides synthetic costimulation in the TME and increases T-cell proliferation and survival, and improves the effector function of T-cells, which may boost the efficacy of TILs."], "t": []}], "preferred_name": "Anti-FOLR1 CoStAR-expressing Autologous Tumor-infiltrating Lymphocytes ITIL-306", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4047029", "l": "post-arteriole capillary cell", "d": ["An endothelial cell forming the walls of capillaries immediately downstream from arterioles, facilitating the exchange of substances between blood and interstitial fluid. This cell is characterized by a small diameter and may be continuous, fenestrated, or sinusoidal, depending on their location and function. This cell plays a crucial role in tissue oxygenation, nutrient delivery, and maintaining homeostasis within the microvascular network."], "t": []}], "preferred_name": "post-arteriole capillary cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C3496569", "l": "A12 dopamine cells", "d": [], "t": []}], "preferred_name": "A12 dopamine cells", "taxa": []}
{"type": "biolink:Cell", "ic": 92.76600187037766, "identifiers": [{"i": "CL:4301580", "l": "CBX MLI Megf11 Gaba_2 molecular layer interneuron (Mmus)", "d": ["A molecular layer interneuron of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Gabra6 (Mmus), Pvalb (Mmus). Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Supertype:1150 CBX MLI Megf11 Gaba_2."], "t": []}], "preferred_name": "CBX MLI Megf11 Gaba_2 molecular layer interneuron (Mmus)", "taxa": []}
{"type": "biolink:Cell", "ic": 89.40238429118027, "identifiers": [{"i": "UMLS:C1708922", "l": "Malignant Transitional Cell with Clear Cytoplasm", "d": [], "t": []}, {"i": "NCIT:C54561", "l": "Malignant Transitional Cell with Clear Cytoplasm", "d": [], "t": []}], "preferred_name": "Malignant Transitional Cell with Clear Cytoplasm", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1521882", "l": "WA07 cell line", "d": [], "t": []}, {"i": "NCIT:C20309", "l": "WA07", "d": ["Provider: Wisconsin Alumni Research Foundation (WARF), Madison, WI. Information from provider and not independently verified by NIH: Cells are positive for cell markers SSEA-3, SSEA-4, TRA-1-60, TRA-1-81, and alkaline phosphatase; Cells are negative for SSEA-1; Give rise to teratomas containing derivatives of three germ layers in SCID mice; Differentiate in vitro. Cells not yet ready for distribution. Publication: Thomson et al., Science 282, 1145, 1998. This cell line meets the criteria for the use of human embryonic stem cells by federally funded researchers."], "t": []}], "preferred_name": "WA07 cell line", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0002505", "l": "liver CD103-negative dendritic cell", "d": ["A CD11b-positive dendritic cell that is CD11b-high, CD45-positive, MHC-II-positive and CD103-negative."], "t": []}], "preferred_name": "liver CD103-negative dendritic cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:1000696", "l": "kidney interstitial inflammatory macrophage", "d": [], "t": []}], "preferred_name": "kidney interstitial inflammatory macrophage", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5170954", "l": "Leukocytes other | Fetus | Pleural fluid | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Leukocytes other | Fetus | Pleural fluid | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5785430", "l": "Autologous Anti-NKG2DL/Anti-CLDN18.2 Bispecific CAR-T Cells KD-496", "d": [], "t": []}, {"i": "NCIT:C192807", "l": "Autologous Anti-NKG2DL/Anti-CLDN18.2 Bispecific CAR-T Cells KD-496", "d": ["A preparation of autologous T-lymphocytes that have been genetically modified to express a tandem chimeric antigen receptor (CAR) targeting the tumor-associated antigens (TAAs) natural-killer group 2, member D ligands (NKG2DLs) and Claudin18.2 (CLDN18.2; A2 isoform of claudin-18), with potential immunostimulating and antineoplastic activities. Upon administration, autologous anti-NKG2DL/anti-CLDN18.2 bispecific CAR-T cells KD-496 specifically and simultaneously recognize and induce selective toxicity in tumor cells expressing NKG2DLs and CLDN18.2. Ligands for NKG2D, such as MHC class I chain-related protein A (MICA), MICB, and members of the UL16-binding proteins (ULBP)/retinoic acid early transcript 1 (RAET1) family, are overexpressed on infected cells and most cancer cell types, but are not expressed on most normal, healthy cells. CLDN18.2, a tight junction protein, is expressed on a variety of tumor cells, but its expression in healthy tissues is strictly confined to short-lived differentiated epithelial cells of the gastric mucosa."], "t": []}], "preferred_name": "Autologous Anti-NKG2DL/Anti-CLDN18.2 Bispecific CAR-T Cells KD-496", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0487470", "l": "Round Cells", "d": [], "t": []}], "preferred_name": "Round Cells", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4307086", "l": "OPC NN_1 Neil3 oligodendrocyte precursor cell (Mmus)", "d": ["A oligodendrocyte precursor cell of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Pdgfra (Mmus), Pclaf (Mmus), Mki67 (Mmus), Foxg1 (Mmus). It is distinguished from other OPC NN_1 cells by expression of Neil3, Foxg1. These cells are located in the Isocortex, brain . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5266 OPC NN_1."], "t": []}], "preferred_name": "OPC NN_1 Neil3 oligodendrocyte precursor cell (Mmus)", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0002440", "l": "Ly49D-positive natural killer cell, mouse", "d": ["A NK1.1-positive T cell that is Ly49D-positive."], "t": []}], "preferred_name": "Ly49D-positive natural killer cell, mouse", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0227693", "l": "Umbrella cell", "d": [], "t": []}, {"i": "SNOMEDCT:16023000", "l": "", "d": [], "t": []}], "preferred_name": "Umbrella cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4047048", "l": "type 4 muscularis propria glia", "d": ["An enteric glial cell characterized by a small central soma that extends long, thin, bipolar projections. This cell is primarily located along small nerve fibers within the muscle layers of the gastrointestinal tract and is known for its unbranching processes that closely follow these nerve fibers in the muscularis."], "t": []}], "preferred_name": "type 4 muscularis propria glia", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4030058", "l": "TCR-positive macrophage", "d": ["A macrophage that expresses the T cell receptor complex at the cell surface."], "t": []}], "preferred_name": "TCR-positive macrophage", "taxa": []}
{"type": "biolink:Cell", "ic": 74.93438803193563, "identifiers": [{"i": "CL:4300028", "l": "cerebellar GABAergic neuron (Mmus)", "d": ["A cerebellar neuron of the Mus musculus brain. Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Class:28 CB GABA."], "t": []}], "preferred_name": "cerebellar GABAergic neuron (Mmus)", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5157382", "l": "CD20+CD25+ cells | Blood | Cell markers", "d": [], "t": []}], "preferred_name": "CD20+CD25+ cells | Blood | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4072035", "l": "sncg GABAergic interneuron (Homo sapiens)", "d": ["A transcriptomically distinct GABAergic neuron located in the cerebral cortex that expresses Gamma-synuclein. The standard transcriptomic reference data for this cell type can be found on the CellxGene census under the collection: 'Transcriptomic cytoarchitecture reveals principles of human neocortex organization', dataset: 'Supercluster: CGE-derived interneurons', Author Categories: 'CrossArea_subclass', clusters Sncg."], "t": []}], "preferred_name": "sncg GABAergic interneuron (Homo sapiens)", "taxa": []}
{"type": "biolink:Cell", "ic": 67.46092100812331, "identifiers": [{"i": "CL:0000028", "l": "CNS neuron (sensu Nematoda and Protostomia)", "d": [], "t": []}], "preferred_name": "CNS neuron (sensu Nematoda and Protostomia)", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5572419", "l": "Acanthocytes | Urine sediment | Urinalysis", "d": [], "t": []}], "preferred_name": "Acanthocytes | Urine sediment | Urinalysis", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5827062", "l": "NSI-566", "d": [], "t": []}], "preferred_name": "NSI-566", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0002396", "l": "CD14-low, CD16-positive monocyte", "d": ["A patrolling monocyte that is CD14-low and CD16-positive."], "t": []}], "preferred_name": "CD14-low, CD16-positive monocyte", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5163727", "l": "Erythrocytes | Synovial fluid | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Erythrocytes | Synovial fluid | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1507324", "l": "CD11b+HLA-DR+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:1373095000", "l": "", "d": [], "t": []}], "preferred_name": "CD11b+HLA-DR+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": 83.11065783093733, "identifiers": [{"i": "CL:4030034", "l": "respiratory tract multiciliated cell", "d": ["A multiciliated epithelial cell located in the respiratory tract epithelium, characterized by a columnar shape and motile cilia on its apical surface. This cell develops through a highly orchestrated process, transitioning from a basal progenitor via an intermediate deuterosomal cell stage that generates centrioles essential for ciliogenesis."], "t": []}], "preferred_name": "respiratory tract multiciliated cell", "taxa": []}
{"type": "biolink:Cell", "ic": 86.30756602822301, "identifiers": [{"i": "UMLS:C1510720", "l": "Abnormal Eosinophil", "d": [], "t": []}, {"i": "NCIT:C37032", "l": "Abnormal Eosinophil", "d": [], "t": []}], "preferred_name": "Abnormal Eosinophil", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C2736937", "l": "CD8+CD45RA+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:1373052004", "l": "", "d": [], "t": []}], "preferred_name": "CD8+CD45RA+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1440266", "l": "CD19+CD38+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:1372982002", "l": "", "d": [], "t": []}], "preferred_name": "CD19+CD38+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": 78.29800561113302, "identifiers": [{"i": "CL:0000707", "l": "R7 photoreceptor cell", "d": [], "t": []}], "preferred_name": "R7 photoreceptor cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0003009", "l": "G6 retinal ganglion cell", "d": ["A mono-stratified retinal ganglion cell that has a medium dendritic field and a sparse dendritic arbor with post sympatic terminals in sublaminar layer S4 and S5."], "t": []}], "preferred_name": "G6 retinal ganglion cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4082186", "l": "Degenerating muscle fiber", "d": [], "t": []}, {"i": "SNOMEDCT:85613007", "l": "", "d": [], "t": []}], "preferred_name": "Degenerating muscle fiber", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5447406", "l": "Interferon Gamma-primed Human Bone Marrow-derived Mesenchymal Stromal Cells", "d": [], "t": []}, {"i": "NCIT:C176740", "l": "Interferon Gamma-primed Human Bone Marrow-derived Mesenchymal Stromal Cells", "d": ["Human bone marrow-derived mesenchymal stromal cells (MSCs) primed with interferon gamma (IFN-g), with potential immunomodulatory activity. Upon priming with IFN-g and the administration of IFN-g-primed human bone marrow-derived MSCs, IFN-g activates the IFN-g-Janus kinase (JAK)-signal transducer and activator of transcription 1 (STAT1) signaling pathway and induces indoleamine 2,3-dioxygenase (IDO) expression in MSCs. This promotes IDO activity and enhances the inhibition of T-cell proliferation mediated by MSCs. This may enhance MSC-mediated immunosuppression and prevent graft-versus-host disease (GvHD)."], "t": []}], "preferred_name": "Interferon Gamma-primed Human Bone Marrow-derived Mesenchymal Stromal Cells", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5392346", "l": "KTE-X19", "d": [], "t": []}], "preferred_name": "KTE-X19", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1978802", "l": "Cytokeratin cells", "d": [], "t": []}], "preferred_name": "Cytokeratin cells", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4316839", "l": "CD16-CD57+", "d": [], "t": []}], "preferred_name": "CD16-CD57+", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C0369715", "l": "Myelocytes", "d": [], "t": []}, {"i": "NCIT:C13115", "l": "Myelocyte", "d": ["A cell derived from a promyelocyte. It differentiates into a metamyelocyte. It has a diameter of 10-18 micrometer, and an oval or round nucleus with finely granulated chromatin."], "t": []}, {"i": "SNOMEDCT:127915008", "l": "", "d": [], "t": []}], "preferred_name": "Myelocytes", "taxa": []}
{"type": "biolink:Cell", "ic": 90.871710685482, "identifiers": [{"i": "CL:4042040", "l": "glutamatergic neuron of the basal ganglia", "d": ["A glutametergic neuron with its soma located in a basal ganglia. This neuron type is involved in motor control, decision making and learning."], "t": []}], "preferred_name": "glutamatergic neuron of the basal ganglia", "taxa": []}
{"type": "biolink:Cell", "ic": 92.76600187037766, "identifiers": [{"i": "UMLS:C1514979", "l": "Strap-Like Skeletal Muscle Cell", "d": [], "t": []}, {"i": "NCIT:C36948", "l": "Strap-Like Skeletal Muscle Cell", "d": [], "t": []}], "preferred_name": "Strap-Like Skeletal Muscle Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5555516", "l": "Autologous Cytokine-induced Killer Cells/Vaccinia Virus DD-CDSR CRX100", "d": [], "t": []}, {"i": "NCIT:C179187", "l": "Autologous Cytokine-induced Killer Cells/Vaccinia Virus DD-CDSR CRX100", "d": ["A preparation of autologous cytokine-induced killer (CIK) cells that have been generated ex vivo from killer cells treated with cytokines and infected with the oncolytic vaccinia virus DD-CDSR (vvDD-CDSR; double-deleted vaccinia virus plus CD/SMR), with potential immunomodulatory and antineoplastic activities. CIK cells are CD3- and CD56-positive, non-major histocompatibility complex (MHC)-restricted, natural killer (NK)-like T-lymphocytes. Upon infusion of autologous CIK cells/vvDD-CDSR CRX100, the CIK cells protect the oncolytic virus vvDD-CDSR from immune attack and enhance the delivery of the oncolytic virus to tumor cells. The oncolytic virus vvDD-CDSR preferentially targets and infects tumor cells causing oncolysis. In turn, the lysed tumor cells release various tumor-associated antigens (TAAs), which induce an immune response against the tumor cells."], "t": []}], "preferred_name": "Autologous Cytokine-induced Killer Cells/Vaccinia Virus DD-CDSR CRX100", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C2350826", "l": "Rhabdomeric Photoreceptor Cells", "d": [], "t": []}], "preferred_name": "Rhabdomeric Photoreceptor Cells", "taxa": []}
{"type": "biolink:Cell", "ic": 92.76600187037766, "identifiers": [{"i": "CL:4052007", "l": "subepithelial intestinal fibroblast", "d": ["A fibroblast located adjacent to the intestinal epithelium in both the small intestine and colon, specifically around the crypts. This cell is characterized by the expression of  PDGFRα and various collagen isoforms, including COL4A5 and COL4A6. It secretes signalling molecules like TGF-β, Wnt ligands, and BMPs, which are crucial for epithelial homeostasis, intestinal stem cell support, and basement membrane formation."], "t": []}], "preferred_name": "subepithelial intestinal fibroblast", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4307042", "l": "Astro-TE NN_2 Clstn2 astrocyte (Mmus)", "d": ["A astrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Gm6145 (Mmus), E330013P04Rik (Mmus), Slc39a12 (Mmus). It is distinguished from other Astro-TE NN_2 cells by expression of Clstn2. These cells are located in the Hippocampal region , in or close to the regions: Dentate gyrus, molecular layer, Dentate gyrus, polymorph layer, Field CA3, stratum oriens, Dentate gyrus, granule cell layer . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5222 Astro-TE NN_2."], "t": []}], "preferred_name": "Astro-TE NN_2 Clstn2 astrocyte (Mmus)", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5964751", "l": "bbT 4015", "d": [], "t": []}], "preferred_name": "bbT 4015", "taxa": []}
{"type": "biolink:Cell", "ic": 85.53200374075534, "identifiers": [{"i": "UMLS:C1515234", "l": "Technion ES Cell Line", "d": [], "t": []}, {"i": "NCIT:C20295", "l": "Technion ES Cell Line", "d": [], "t": []}], "preferred_name": "Technion ES Cell Line", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5555727", "l": "WT1/PRAME/Survivin-specific T-cells MANA-312", "d": [], "t": []}, {"i": "NCIT:C179500", "l": "WT1/PRAME/Survivin-specific T-cells MANA-312", "d": ["A preparation of off-the-shelf (OTS) donor-derived T-lymphocytes that are reactive to multiple tumor-associated antigens (TAAs), with potential immunomodulating and antineoplastic activities. T-cells derived from allogeneic donor leukocytes are stimulated with monocyte-derived dendritic cells (DCs) that are pulsed with a mix of peptides derived from the three TAAs Wilms tumor 1 (WT1), preferentially expressed antigen of melanoma (PRAME; melanoma antigen preferentially expressed in tumors; Opa-interacting protein 4; OIP-4) and survivin (baculoviral IAP repeat-containing protein 5; BIRC5). The antigen-specific T-cells are subsequently expanded. Upon administration of WT1/PRAME/survivin-specific T-cells MANA 312, the T-cells recognize, induce a T-cell mediated immune response in and induce lysis of tumor cells that express WT1, PRAME and/or survivin. In addition, tumor cell lysis induces the release of a broader set of tumor antigens, thereby further stimulating the immune system to exert an anti-tumor T-cell-mediated immune response. WT1, PRAME and survivin, overexpressed in a variety of tumor cell types, play key roles in tumor cell proliferation."], "t": []}], "preferred_name": "WT1/PRAME/Survivin-specific T-cells MANA-312", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0333767", "l": "Lobulated fibers", "d": [], "t": []}, {"i": "SNOMEDCT:62655004", "l": "", "d": [], "t": []}], "preferred_name": "Lobulated fibers", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5960033", "l": "Belacabnagene Franleucel", "d": [], "t": []}, {"i": "NCIT:C206880", "l": "Belacabnagene Franleucel", "d": [], "t": []}], "preferred_name": "Belacabnagene Franleucel", "taxa": []}
{"type": "biolink:Cell", "ic": 81.743421370964, "identifiers": [{"i": "CL:0000695", "l": "Cajal-Retzius cell", "d": ["A type of transient, early-born glutamatergic neuron located primarily in the marginal zone (future layer I) of the developing cerebral cortex and hippocampus in vertebrates. it is characterized by a bipolar morphology with an elongated soma, a single thick dendrite oriented toward the pial surface, and a long, thin axon that extends tangentially to form horizontal plexuses across the cortical surface. It is important for the multiple developmental processes including migration, dendritogenesis and synaptogenesis. It typically undergoes programmed cell death following cortical maturation with species- and region specific patterns of survival. In mice, it is predominantly observed in the hippocampal formation, particularly in the stratum lacunosum-moleculare and outer molecular layer of the dentate gyrus (van Bruggen et al., 2023). In contrast, in humans, a second morphologically distinct subpopulation emerges mid-gestation and persists postnatally, with surviving cells observed in the cortical sulci and the hippocampus."], "t": []}], "preferred_name": "Cajal-Retzius cell", "taxa": []}
{"type": "biolink:Cell", "ic": 79.35380886648232, "identifiers": [{"i": "UMLS:C1708884", "l": "Malignant Hyperchromatic Squamous Cell", "d": [], "t": []}, {"i": "NCIT:C54208", "l": "Malignant Hyperchromatic Squamous Cell", "d": [], "t": []}], "preferred_name": "Malignant Hyperchromatic Squamous Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0002318", "l": "peripheral blood mesothelial cell", "d": ["A mesothelial cell capable of circulating in the blood by first losing its squamous character. This cell can incorporate into the regenerating mesothelium."], "t": []}, {"i": "UMLS:C2328384", "l": "Peripheral blood mesothelial cell", "d": [], "t": []}], "preferred_name": "peripheral blood mesothelial cell", "taxa": []}
{"type": "biolink:Cell", "ic": 72.31349143091559, "identifiers": [{"i": "CL:0000349", "l": "extraembryonic cell", "d": ["Any cell that is part of some extraembryonic structure."], "t": []}], "preferred_name": "extraembryonic cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5157387", "l": "CD20+FMC7+ cells | XXX | Cell markers", "d": [], "t": []}], "preferred_name": "CD20+FMC7+ cells | XXX | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C4761464", "l": "Autologous CD4+/CD8+ 4-1BB-CD3zeta-EGFR806-CAR-EGFRt/4-1BB-CD3zeta-CD19-CAR-HER2tG-expressing CARs T Cells", "d": [], "t": []}, {"i": "NCIT:C157090", "l": "Autologous CD4+/CD8+ 4-1BB-CD3zeta-EGFR806-CAR-EGFRt/4-1BB-CD3zeta-CD19-CAR-HER2tG-expressing CARs T Cells", "d": ["A preparation of CD4+ and CD8+ autologous T-lymphocytes transduced with a lentiviral vector that co-expresses two different second generation chimeric antigen receptors (CARs), one composed of a short chain variable fragment (scFv) binding domain derived from depatuxizumab, a human anti-epidermal growth factor receptor (EGFR) monoclonal antibody (MAb806; ABT-806), coupled to the zeta chain of the TCR/CD3 complex (CD3-zeta) and the signaling domain of 4-1BB (CD137), and linked to a truncated form of the human epidermal growth factor receptor (EGFRt), and one composed of a short chain variable fragment (scFv) binding domain derived from an anti-CD19 monoclonal antibody, coupled to CD3-zeta) and 4-1BB,  and linked to a truncated form of the human epidermal growth factor receptor 2 (HER2tG), with potential immunostimulating and antineoplastic activities. Upon intravenous administration, the autologous CD4+/CD8+ 4-1BB-CD3zeta-EGFR806-CAR-EGFRt/4-1BB-CD3zeta- CD19-CAR-HER2tG-expressing CARs T-cells are directed to, bind to, and induce selective toxicity in EGFR deletion mutation variant III (EGFRvIII)-expressing tumor cells. The binding of these T-cells to CD19 expressed on B-cells enhances their expansion and prolongs their persistence in vivo, thereby increasing the efficacy of these CAR T-cells. Devoid of both ligand binding domains and tyrosine kinase activity, the expressed EGFRt and HER2tG facilitate in vivo detection of the administered, transduced T-cells and can promote elimination of these cells through an antibody-dependent cellular cytotoxicity (ADCC) response. HER2tG allows for enhanced binding by trastuzumab. EGFRvIII, an in-frame deletion of exons 2-7 in the EGFR gene, is overexpressed by a variety of cancer cell types but absent in normal, healthy cells. It plays a key role in tumor cell proliferation, tumor angiogenesis and resistance to both radio- and chemotherapy. Depatuxizumab specifically targets abnormal conformational states of EGFR, including EGFRvIII, and activating mutations, with lower affinity for wild-type EGFR. CD19, a transmembrane phosphoglycoprotein is expressed on the surface of cells in the B-lineage."], "t": []}], "preferred_name": "Autologous CD4+/CD8+ 4-1BB-CD3zeta-EGFR806-CAR-EGFRt/4-1BB-CD3zeta-CD19-CAR-HER2tG-expressing CARs T Cells", "taxa": []}
{"type": "biolink:Cell", "ic": 90.871710685482, "identifiers": [{"i": "CL:0001007", "l": "interstitial dendritic cell", "d": ["Interstitial dendritic cell is a conventional dendritic cell that is CD11b-positive, CD1a-positive, CD206-positive, CD209-positive, and CD36-positive."], "t": []}], "preferred_name": "interstitial dendritic cell", "taxa": []}
{"type": "biolink:Cell", "ic": 83.63771255585968, "identifiers": [{"i": "UMLS:C5856853", "l": "Anti-CD123 CAR T Cells Preparation", "d": [], "t": []}, {"i": "NCIT:C201493", "l": "Anti-CD123 CAR T Cells Preparation", "d": ["Any preparation of chimeric antigen receptor (CAR) expressing T-lymphocytes that targets the tumor-associated antigen (TAA) CD123."], "t": []}], "preferred_name": "Anti-CD123 CAR T Cells Preparation", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:1000284", "l": "smooth muscle fiber of descending colon", "d": ["A smooth muscle cell that is part of the descending colon."], "t": []}, {"i": "UMLS:C0736250", "l": "Smooth muscle fiber of descending colon", "d": [], "t": []}], "preferred_name": "smooth muscle fiber of descending colon", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0005007", "l": "Kolmer-Agduhr neuron", "d": ["Kolmer-Agduhr neurons are ciliated GABAergic neurons that contact the central canal of the spinal cord and have ipsilateral ascending axons."], "t": []}], "preferred_name": "Kolmer-Agduhr neuron", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0009088", "l": "circulating angiogenic cell", "d": ["An adult endothelial progenitor cell characterised in vivo by homing to ischemic sites and paracrine support of angiogenesis. These cells do not form colonies."], "t": []}], "preferred_name": "circulating angiogenic cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4033033", "l": "flat midget bipolar cell", "d": ["An OFF bipolar cell with a small dendritic tree that provides most of the triad-associated basal (flat) contacts at cone pedicles."], "t": []}], "preferred_name": "flat midget bipolar cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5977933", "l": "Granulocytes | Synovial fluid | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Granulocytes | Synovial fluid | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4310093", "l": "arkypallidal neuron (Primate)", "d": ["A arkypallidal neuron of the Primates brain. These cells are located in the striatum, external segment of globus pallidus . Reference transcriptomic data for this type can be found in the dataset/taxonomy - HMBA Basal Ganglia Consensus Taxonomy in cell set Group:GPe MEIS2-SOX6 GABA."], "t": []}], "preferred_name": "arkypallidal neuron (Primate)", "taxa": []}
{"type": "biolink:Cell", "ic": 66.29970550272421, "identifiers": [{"i": "CL:1001611", "l": "cerebellar neuron", "d": ["Neuron of the cerebellum."], "t": []}, {"i": "UMLS:C0682702", "l": "Cerebellar neuron", "d": [], "t": []}], "preferred_name": "cerebellar neuron", "taxa": []}
{"type": "biolink:Cell", "ic": 78.05853671694304, "identifiers": [{"i": "CL:4023161", "l": "unipolar brush cell", "d": ["An excitatory glutamatergic interneuron found in the granular layer of the cerebellar cortex and also in the granule cell domain of the cochlear nucleus. Unipolar brush cells have a round or oval cell body with usually a single short dendrite that ends in a brush-like tuft of short dendrites unique to them known as dendrioles."], "t": []}], "preferred_name": "unipolar brush cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5909548", "l": "Autologous Retroviral Vector MSGV1-transduced Anti-PSCA-8T28Z CAR Gamma Delta T-cells", "d": [], "t": []}, {"i": "NCIT:C204025", "l": "Autologous Retroviral Vector MSGV1-transduced Anti-PSCA-8T28Z CAR Gamma Delta T-cells", "d": ["A preparation of autologous gamma, delta T-lymphocytes transduced with the gamma retroviral vector MSGV1 expressing a chimeric antigen receptor (CAR) targeting the tumor-associated antigen (TAA) prostate stem cell antigen (PSCA), and expressing a hinge/transmembrane domain derived from CD8alpha (CD8a) and a single co-stimulatory domain derived from CD28 (8t28z), with potential immunomodulating and antineoplastic activities. Upon administration, the autologous retroviral vector MSGV1-transduced anti-PSCA-8T28Z CAR gamma delta T-cells specifically target, bind to and kill tumor cells expressing PSCA. PSCA is a glycosyl-phosphatidylinositol (GPI)-linked cell surface antigen found in various cancers."], "t": []}], "preferred_name": "Autologous Retroviral Vector MSGV1-transduced Anti-PSCA-8T28Z CAR Gamma Delta T-cells", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1518312", "l": "Nevus Cell A-Type", "d": [], "t": []}, {"i": "NCIT:C36864", "l": "Nevus Cell A-Type", "d": [], "t": []}], "preferred_name": "Nevus Cell A-Type", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C4744619", "l": "Autologous Anti-CD38 A2 CAR2-expressing T-cells", "d": [], "t": []}, {"i": "NCIT:C156170", "l": "Autologous Anti-CD38 A2 CAR2-expressing T-cells", "d": ["A preparation of genetically modified autologous T-cells expressing a chimeric antigen receptor recognizing the tumor-associated antigen (TAA) cluster of differentiation 38 (CD38), with potential immunostimulating and antineoplastic activities. Upon intravenous administration, autologous anti-CD38 A2 CAR2-expressing T-cells are directed to and induce selective toxicity in CD38-expressing tumor cells. CD38, a type II transmembrane glycoprotein, is present on various immune cells and hematologic malignancies, and its expression has been correlated with poor prognosis."], "t": []}], "preferred_name": "Autologous Anti-CD38 A2 CAR2-expressing T-cells", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0010002", "l": "epithelial cell of umbilical artery", "d": ["An epithelial cell that is part_of a umbilical artery."], "t": []}], "preferred_name": "epithelial cell of umbilical artery", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5157312", "l": "CD14+CD16+CD59+ cells | Serum | Cell markers", "d": [], "t": []}], "preferred_name": "CD14+CD16+CD59+ cells | Serum | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5157410", "l": "CD25 cells | Blood | Cell markers", "d": [], "t": []}], "preferred_name": "CD25 cells | Blood | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C4687729", "l": "Anti-NY-ESO-1 TCR LV-transduced Autologous T-Cells TAEST16001", "d": [], "t": []}, {"i": "NCIT:C147135", "l": "Anti-NY-ESO-1 TCR LV-transduced Autologous T-Cells TAEST16001", "d": ["A preparation of human autologous T-lymphocytes that are transduced with a lentiviral vector (LV) encoding an affinity-enhanced T-cell receptor (TCR) specific for the cancer-testis antigen NY-ESO-1, with potential immunostimulating and antineoplastic activities. Upon isolation, transduction, expansion ex vivo, and reintroduction into the patient, the anti-NY-ESO-1 TCR LV-transduced autologous T-cells TAEST16001 recognize and bind to NY-ESO-1-overexpressing tumor cells. This may result in a specific cytotoxic T-lymphocyte (CTL)-mediated killing of NY-ESO-1-positive tumor cells. NY-ESO-1, a tumor-associated antigen (TAA), is found in normal testis and on the surface of various tumor cell types, and is not, or is minimally, expressed in normal, healthy cells."], "t": []}], "preferred_name": "Anti-NY-ESO-1 TCR LV-transduced Autologous T-Cells TAEST16001", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5157349", "l": "CD19+21- cells | Blood | Cell markers", "d": [], "t": []}], "preferred_name": "CD19+21- cells | Blood | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": 81.34422831136257, "identifiers": [{"i": "CL:0002260", "l": "epithelial cell of parathyroid gland", "d": ["An epithelial cell of the parathyroid gland."], "t": []}, {"i": "UMLS:C1182608", "l": "Epithelial cell of parathyroid gland", "d": [], "t": []}], "preferred_name": "epithelial cell of parathyroid gland", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "UMLS:C5707268", "l": "Malignant Thyroid Gland Follicular Signet Ring Cell", "d": [], "t": []}, {"i": "NCIT:C187642", "l": "Malignant Thyroid Gland Follicular Signet Ring Cell", "d": ["A malignant thyroid gland follicular cell with cytoplasmic vacuole and eccentrically placed nucleus."], "t": []}], "preferred_name": "Malignant Thyroid Gland Follicular Signet Ring Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 88.20185721311867, "identifiers": [{"i": "CL:1001437", "l": "hair-down neuron", "d": ["The subcutaneous mechanoreceptors that innervate vellus hairs."], "t": []}], "preferred_name": "hair-down neuron", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4696638", "l": "CD4+CD25+CD45RO+CD127low cell", "d": [], "t": []}, {"i": "SNOMEDCT:1376034008", "l": "", "d": [], "t": []}], "preferred_name": "CD4+CD25+CD45RO+CD127low cell", "taxa": []}
{"type": "biolink:Cell", "ic": 92.76600187037766, "identifiers": [{"i": "CL:1000547", "l": "kidney inner medulla collecting duct epithelial cell", "d": ["An epithelial cell that is part of some inner medullary collecting duct."], "t": []}], "preferred_name": "kidney inner medulla collecting duct epithelial cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4072031", "l": "sst chodl GABAergic interneuron (Homo sapiens)", "d": ["A transcriptomically distinct sst GABAergic interneuron that also expresses Chodl. These neurons are rare and correspond to the only known interneurons with long-range projection. The standard transcriptomic reference data for this cell type can be found on the CellxGene census under the collection: 'Transcriptomic cytoarchitecture reveals principles of human neocortex organization', dataset: 'Supercluster: MGE-derived interneurons', Author Categories: 'CrossArea_subclass', clusters Sst Chodl."], "t": []}], "preferred_name": "sst chodl GABAergic interneuron (Homo sapiens)", "taxa": []}
{"type": "biolink:Cell", "ic": 52.4369898510679, "identifiers": [{"i": "UMLS:C1515139", "l": "T-Lymphocyte and Natural Killer Cell", "d": [], "t": []}, {"i": "NCIT:C39567", "l": "T-Lymphocyte and Natural Killer Cell", "d": ["Group of lymphocytes. A T-lymphocyte is a white blood cell differentiated in the thymus that possesses highly specific cell-surface antigen receptors. A natural killer cell resembles a T-lymphocyte, but it does not express markers of either T or B cell lineage. Its cytotoxic activity is not antibody dependent."], "t": []}], "preferred_name": "T-Lymphocyte and Natural Killer Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 87.18682603146104, "identifiers": [{"i": "UMLS:C5984628", "l": "Anti-GPRC5D CAR T Cells Preparation", "d": [], "t": []}, {"i": "NCIT:C212993", "l": "Anti-GPRC5D CAR T Cells Preparation", "d": ["Any preparation of CAR-T cells that targets human G-protein coupled receptor family C group 5 member D (GPRC5D)."], "t": []}], "preferred_name": "Anti-GPRC5D CAR T Cells Preparation", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1507172", "l": "CD3+TCR gamma delta+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:1376049000", "l": "", "d": [], "t": []}], "preferred_name": "CD3+TCR gamma delta+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1182626", "l": "Epithelial cell of paranasal sinus part of viscerocranial mucosa", "d": [], "t": []}], "preferred_name": "Epithelial cell of paranasal sinus part of viscerocranial mucosa", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C4733685", "l": "Autologous HER2-specific/EGFRt-expressing CD4/CD8-positive CAR T-cells", "d": [], "t": []}, {"i": "NCIT:C156156", "l": "Autologous HER2-specific/EGFRt-expressing CD4/CD8-positive CAR T-cells", "d": ["A preparation of CD4+ and CD8+ autologous T-lymphocytes transduced with a lentiviral vector expressing a human epidermal growth factor receptor type 2 (HER2; EGFR2; ErbB2)-specific chimeric antigen receptor (CAR) coupled to a truncated form of the human epidermal growth factor receptor (EGFRt), with potential immunostimulating and antineoplastic activities. Upon intravenous administration, the autologous HER2-specific/EGFRt-expressing CD4/CD8-positive CAR T-cells are directed to and induce selective toxicity in HER2-expressing tumor cells. Devoid of both ligand binding domains and tyrosine kinase activity, the expressed EGFRt both facilitates in vivo detection of the administered, transduced T-cells and can promote elimination of these cells through an anti-EGFR antibody-induced antibody-dependent cellular cytotoxicity (ADCC) response. HER2, a receptor tyrosine kinase (RTK) overexpressed by a variety of tumor cell types, belongs to the EGFR superfamily and plays a key role in tumor cell proliferation."], "t": []}], "preferred_name": "Autologous HER2-specific/EGFRt-expressing CD4/CD8-positive CAR T-cells", "taxa": []}
{"type": "biolink:Cell", "ic": 52.15955112550235, "identifiers": [{"i": "CL:0008004", "l": "somatic muscle cell", "d": ["A muscle cell that is part of some somatic muscle."], "t": []}], "preferred_name": "somatic muscle cell", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "UMLS:C1514094", "l": "Neoplastic Small T-Prolymphocyte", "d": [], "t": []}, {"i": "NCIT:C39571", "l": "Neoplastic Small T-Prolymphocyte", "d": [], "t": []}], "preferred_name": "Neoplastic Small T-Prolymphocyte", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5776719", "l": "Erythrocytes.parasite sp infected", "d": [], "t": []}], "preferred_name": "Erythrocytes.parasite sp infected", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5238462", "l": "Fas Ligand-treated Allogeneic Mobilized Peripheral Blood Cells", "d": [], "t": []}, {"i": "NCIT:C167326", "l": "Fas Ligand-treated Allogeneic Mobilized Peripheral Blood Cells", "d": ["A donor graft derived from allogeneic filgrastim (granulocyte-colony stimulating factor; G-CSF)-mobilized peripheral blood cells (MPBC) that have been incubated with the recombinant human Fas ligand (FasL) APO010 ex vivo, and that can potentially be used for immune reconstitution purposes. The incubation of the hematopoietic stem cell graft with the apoptotic mediator Fas ligand (FasL) selectively induces apoptosis of mature T-cells which express high levels of Fas receptor, such as T stem cell memory (TSCM), T central memory (TCM), and T effector memory (TEM) cells and the pro-inflammatory T-helper cells (Th) Th1 and Th17 subsets while sparing CD34-positive stem and progenitor cells. Upon washing and further ex vivo preparations, and upon allogeneic hematopoietic stem cell transplantation (HSCT) with the FasL-treated allogeneic MPBCs, these cells provide hematopoietic cell recovery, preserve the graft-versus-leukemia (GvL) effects, and may prevent graft-versus-host disease (GvHD)."], "t": []}], "preferred_name": "Fas Ligand-treated Allogeneic Mobilized Peripheral Blood Cells", "taxa": []}
{"type": "biolink:Cell", "ic": 79.9528279018387, "identifiers": [{"i": "CL:0005012", "l": "multiciliated epithelial cell", "d": ["A columnar/cuboidal epithelial cell with multiple motile cilia on its apical surface. These cells facilitate the movement of liquids such as mucus or cerebrospinal fluid across the epithelial surface."], "t": []}], "preferred_name": "multiciliated epithelial cell", "taxa": []}
{"type": "biolink:Cell", "ic": 89.40238429118027, "identifiers": [{"i": "UMLS:C1710537", "l": "Undifferentiated Neoplastic Blast", "d": [], "t": []}, {"i": "NCIT:C42873", "l": "Undifferentiated Neoplastic Blast", "d": [], "t": []}], "preferred_name": "Undifferentiated Neoplastic Blast", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5157280", "l": "CD122 cells | Blood | Cell markers", "d": [], "t": []}], "preferred_name": "CD122 cells | Blood | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5827063", "l": "Palucorcel", "d": [], "t": []}], "preferred_name": "Palucorcel", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5855297", "l": "Suvutresgene Autoleucel", "d": [], "t": []}, {"i": "NCIT:C199017", "l": "Suvutresgene Autoleucel", "d": [], "t": []}], "preferred_name": "Suvutresgene Autoleucel", "taxa": []}
{"type": "biolink:Cell", "ic": 64.27850053695266, "identifiers": [{"i": "UMLS:C1522078", "l": "Abnormal Granulocyte", "d": [], "t": []}, {"i": "NCIT:C37050", "l": "Abnormal Granulocyte", "d": [], "t": []}], "preferred_name": "Abnormal Granulocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0002552", "l": "fibroblast of gingiva", "d": ["Any fibroblast that is part of some gingiva."], "t": []}], "preferred_name": "fibroblast of gingiva", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4033029", "l": "diffuse bipolar 3a cell", "d": ["An OFF calbindin-positive bipolar cell that has a large dendritic field and stratifies narrowly close to the middle of the inner plexiform layer. Its axon terminal is characterized by regularly branching and varicose processes resembling beads on a string. Most of DB3a contacts with cones are triad-associated."], "t": []}], "preferred_name": "diffuse bipolar 3a cell", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "UMLS:C0242633", "l": "T-helper cell type 2", "d": [], "t": []}, {"i": "NCIT:C12540", "l": "Type 2 Helper Cell", "d": ["Type 2 Helper Cells are a subset of helper-inducer T-lymphocytes which synthesize and secrete the interleukins IL-4, IL-5, IL-6, and IL-10. These cytokines influence B-cell development and antibody production as well as augmenting humoral responses."], "t": []}, {"i": "MESH:D018418", "l": "Th2 Cells", "d": [], "t": []}, {"i": "SNOMEDCT:418340005", "l": "", "d": [], "t": []}], "preferred_name": "T-helper cell type 2", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C2936408", "l": "Mesophyll Cells", "d": [], "t": []}, {"i": "MESH:D058503", "l": "Mesophyll Cells", "d": [], "t": []}], "preferred_name": "Mesophyll Cells", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5382906", "l": "HLA-B35 CMV specific CD8 cells | Blood | Cell markers", "d": [], "t": []}], "preferred_name": "HLA-B35 CMV specific CD8 cells | Blood | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "UMLS:C1708906", "l": "Malignant Small Osteoblast", "d": [], "t": []}, {"i": "NCIT:C53956", "l": "Malignant Small Osteoblast", "d": [], "t": []}], "preferred_name": "Malignant Small Osteoblast", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0020058", "l": "nitrergic neuron of myenteric plexus", "d": ["An enteric neuron whose soma resides in the myenteric plexus and which is capable of nitric oxide biosynthetic process. This is a defined grouping class that autoclassifies spiny Dogiel type I neurons (the nitrergic motor neuron morphotype)."], "t": []}], "preferred_name": "nitrergic neuron of myenteric plexus", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5154301", "l": "Band form neutrophils | Synovial fluid | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Band form neutrophils | Synovial fluid | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": 63.23452570929499, "identifiers": [{"i": "CL:0000340", "l": "glioblast (sensu Nematoda and Protostomia)", "d": ["A precursor of the central nervous system that gives rise to glial cells only."], "t": []}], "preferred_name": "glioblast (sensu Nematoda and Protostomia)", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5833407", "l": "Autologous CD34+ enriched cell fraction that contains CD34+ cells transduced with retroviral vector that encodes for the human ADA cDNA sequence", "d": [], "t": []}], "preferred_name": "Autologous CD34+ enriched cell fraction that contains CD34+ cells transduced with retroviral vector that encodes for the human ADA cDNA sequence", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:1000308", "l": "fibrocyte of adventitia of ureter", "d": ["A stromal cell that is part of the outer adventitial layer of the ureter. This cell type is marked by expression of periostin (POSTN) in mice, and it is derived from Foxd1+ mesenchymal progenitors around embryonic day 12.5. The adventitial fibrocyte initiates differentiation earlier than smooth muscle cells and becomes terminally differentiated by E16.5-18.5 in mice, exhibiting low proliferative capacity in adulthood."], "t": []}, {"i": "UMLS:C2328623", "l": "Fibrocyte of adventitia of ureter", "d": [], "t": []}], "preferred_name": "fibrocyte of adventitia of ureter", "taxa": []}
{"type": "biolink:Cell", "ic": 75.54735764213513, "identifiers": [{"i": "CL:0000016", "l": "male germ line stem cell", "d": ["A stem cell that is the precursor of male gametes."], "t": []}], "preferred_name": "male germ line stem cell", "taxa": []}
{"type": "biolink:Cell", "ic": 92.76600187037766, "identifiers": [{"i": "CL:4301578", "l": "cerebellar Golgi cell (Mmus)", "d": ["A cerebellar Golgi cell of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Zfp385c (Mmus), Tfap2b (Mmus). Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Supertype:1148 CBX Golgi Gly-Gaba_1."], "t": []}], "preferred_name": "cerebellar Golgi cell (Mmus)", "taxa": []}
{"type": "biolink:Cell", "ic": 87.18682603146104, "identifiers": [{"i": "UMLS:C1180350", "l": "Taste bud cell", "d": [], "t": []}, {"i": "NCIT:C13147", "l": "Taste Bud Cell", "d": ["Any of the three types of the cells that constitute the taste bud. They are classified as neuroepithelial (sensory) cells, supporting cells, and basal cells."], "t": []}], "preferred_name": "Taste bud cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5554926", "l": "Partially HLA-matched AdV/CMV/EBV/BKV-specific Allogeneic T-lymphocytes", "d": [], "t": []}, {"i": "NCIT:C178297", "l": "Partially HLA-matched AdV/CMV/EBV/BKV-specific Allogeneic T-lymphocytes", "d": ["A preparation of partially human leukocyte antigen (HLA)-matched allogeneic cytotoxic T-lymphocytes (CTLs) that are specifically reactive to the four viruses adenovirus (AdV), cytomegalovirus (CMV), Epstein-Barr virus (EBV) and human polyomavirus type I (BKV), with potential antiviral activity. Upon infusion of the partially HLA-matched AdV/CMV/EBV/BKV-specific allogeneic T-lymphocytes upon allogeneic hematopoietic stem cell transplantation (HSCT) in an immunodeficient recipient, these CTLs may kill AdV, CMV, EBV and/or BKV-infected cells, and may prevent or reduce the severity of viral infections by these pathogens."], "t": []}], "preferred_name": "Partially HLA-matched AdV/CMV/EBV/BKV-specific Allogeneic T-lymphocytes", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4072027", "l": "sst GABAergic interneuron (Homo sapiens)", "d": ["A transcriptomically distinct GABAergic neuron located in the cerebral cortex that expresses somatostatin (sst). The standard transcriptomic reference data for this cell type can be found on the CellxGene census under the collection: 'Transcriptomic cytoarchitecture reveals principles of human neocortex organization', dataset: 'Supercluster: MGE-derived interneurons', Author Categories: 'CrossArea_subclass', cluster Sst."], "t": []}], "preferred_name": "sst GABAergic interneuron (Homo sapiens)", "taxa": []}
{"type": "biolink:Cell", "ic": 76.40371442623734, "identifiers": [{"i": "UMLS:C1709193", "l": "Neoplastic Perivascular Epithelioid Cell", "d": [], "t": []}, {"i": "NCIT:C53681", "l": "Neoplastic Perivascular Epithelioid Cell", "d": [], "t": []}], "preferred_name": "Neoplastic Perivascular Epithelioid Cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1267831", "l": "Lymphocyte positive for both CD3 antigen and CD56 antigen", "d": [], "t": []}, {"i": "SNOMEDCT:117522007", "l": "", "d": [], "t": []}], "preferred_name": "Lymphocyte positive for both CD3 antigen and CD56 antigen", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "CL:0000743", "l": "hypertrophic chondrocyte", "d": ["A chondrocyte that is part of the hypertrophic cartilage zone. This cell is significantly enlarged and characterised by high expression of type X collagen (COL10A1) in both humans and mice. It actively coordinates endochondral ossification by mineralising the extracellular matrix, attracting blood vessels via angiogenic signalling, and mediating the transition from cartilage to bone - often by transdifferentiating into an osteoblast rather than undergoing apoptosis."], "t": []}], "preferred_name": "hypertrophic chondrocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0009110", "l": "lymphatic endothelial cell of medulla ceiling", "d": ["A lymphatic endothelial cell located in the ceiling part of a lymph node medulla."], "t": []}], "preferred_name": "lymphatic endothelial cell of medulla ceiling", "taxa": []}
{"type": "biolink:Cell", "ic": 73.73386095387401, "identifiers": [{"i": "UMLS:C1510735", "l": "Abnormal Syncytiotrophoblastic Cell", "d": [], "t": []}, {"i": "NCIT:C36800", "l": "Abnormal Syncytiotrophoblastic Cell", "d": [], "t": []}], "preferred_name": "Abnormal Syncytiotrophoblastic Cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C6065176", "l": "RD06-04", "d": [], "t": []}], "preferred_name": "RD06-04", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C2323619", "l": "Set of astrocytes", "d": [], "t": []}], "preferred_name": "Set of astrocytes", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5157336", "l": "CD179a blasts | Blood | Cell markers", "d": [], "t": []}], "preferred_name": "CD179a blasts | Blood | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1267806", "l": "LEU M3+ lymphocyte", "d": [], "t": []}, {"i": "SNOMEDCT:117510009", "l": "", "d": [], "t": []}], "preferred_name": "LEU M3+ lymphocyte", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0007601", "l": "Cell Line, Transformed", "d": [], "t": []}, {"i": "MESH:D002461", "l": "Cell Line, Transformed", "d": [], "t": []}], "preferred_name": "Cell Line, Transformed", "taxa": []}
{"type": "biolink:Cell", "ic": 75.876659701315, "identifiers": [{"i": "CL:0000149", "l": "visual pigment cell", "d": [], "t": []}], "preferred_name": "visual pigment cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1513747", "l": "Multinucleated Reed-Sternberg Cell", "d": [], "t": []}, {"i": "NCIT:C36813", "l": "Multinucleated Reed-Sternberg Cell", "d": [], "t": []}], "preferred_name": "Multinucleated Reed-Sternberg Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5555826", "l": "Allogeneic Anti-CD7 CAR T Cells", "d": [], "t": []}, {"i": "NCIT:C179630", "l": "Allogeneic Anti-CD7 CAR T Cells", "d": ["A preparation of donor-derived T-lymphocytes that have been genetically engineered to express a chimeric antigen receptor (CAR) directed against the tumor-associated antigen (TAA) CD7, with potential immunostimulating and antineoplastic activities. Upon intravenous administration, the allogeneic anti-CD7 CAR T cells specifically recognize and bind to CD7-expressing tumor cells, resulting in specific T-cell-mediated tumor cell lysis. CD7 is a transmembrane glycoprotein expressed by T-cells and natural killer (NK) cells and their precursors. It is expressed in the majority of lymphoblastic T-cell leukemias and lymphomas and in a subset of peripheral T-cell lymphomas."], "t": []}], "preferred_name": "Allogeneic Anti-CD7 CAR T Cells", "taxa": []}
{"type": "biolink:Cell", "ic": 74.93438803193563, "identifiers": [{"i": "CL:4023029", "l": "indirect pathway medium spiny neuron", "d": ["A medium spiny neuron that expresses dopamine type 2 receptors and projects to the external globus pallidus.", "A GABAergic medium spiny neuron located in the striatum that gives rise to the indirect basal ganglia pathway. It projects to the GPe, where its axon typically ramifies in two regions but does not extend beyond this nucleus (Gerfen et al., 2022). It selectively expresses the D2 dopamine receptor (DRD2), which couples to inhibitory G-proteins (Gi/o) to decrease cAMP and suppress PKA-mediated signaling (Gerfen et al., 2022). Morphologically, this cell displays fewer and shorter dendrites than the MSN-D1 and receives fewer glutamatergic inputs, yet it exhibits significantly higher intrinsic excitability (Gertler et al., 2022). Functionally, activation of this cell suppresses competing or alternative motor actions by inhibiting GPe neurons, leading through STN and other GPe circuits to increased GPi/SNr output and stronger inhibition of thalamic and brainstem targets (Mink, 1996; Tecuapetla et al., 2016)."], "t": []}], "preferred_name": "indirect pathway medium spiny neuron", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1720886", "l": "Melanotrophs", "d": [], "t": []}, {"i": "MESH:D052717", "l": "Melanotrophs", "d": [], "t": []}], "preferred_name": "Melanotrophs", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C0333800", "l": "Blister cell", "d": [], "t": []}, {"i": "NCIT:C206315", "l": "Prekeratocyte", "d": ["An abnormal red blood cell with predominantly single, sharply defined, submembranous vacuoles and central pallor."], "t": []}, {"i": "SNOMEDCT:1382289005", "l": "", "d": [], "t": []}], "preferred_name": "Blister cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5163723", "l": "Erythrocytes | Prostatic fluid | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Erythrocytes | Prostatic fluid | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5984736", "l": "Autologous TGFbRII-knockout Anti-interleukin-13 Receptor Alpha 2 CAR T-cells", "d": [], "t": []}, {"i": "NCIT:C213207", "l": "Autologous TGFbRII-knockout Anti-interleukin-13 Receptor Alpha 2 CAR T-cells", "d": ["A preparation of autologous T-lymphocytes engineered to express a chimeric antigen receptor (CAR) specific for interleukin-13 receptor alpha 2 (IL13Ra2), and to knock out the expression of transforming growth factor-beta receptor II (TGFbRII), with potential immunostimulating and antineoplastic activities. Upon administration, autologous TGFbRII-KO anti-IL13Ra2 CAR T-cells target and bind to IL13Ra2 expressed on the surface of tumor cells. This induces selective toxicity in tumor cells expressing IL13Ra2. IL13Ra2, a cancer-associated receptor, is overexpressed by a variety of tumor cell types including glioblastoma multiforme (GBM); it is associated with increased invasiveness of tumor cells. By knocking out the expression of TGFbRII, the immunosuppressive cytokine TGF-beta is unable to bind to the T-cells and prevent the activation of the T-cells. TGF-beta contributes to the immunosuppressive nature of the tumor microenvironment (TME), and plays a key role in promoting tumor initiation, metastasis, and suppressing anti-tumor immunity."], "t": []}], "preferred_name": "Autologous TGFbRII-knockout Anti-interleukin-13 Receptor Alpha 2 CAR T-cells", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4323048", "l": "Oocyte in metaphase II arrest", "d": [], "t": []}], "preferred_name": "Oocyte in metaphase II arrest", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5163546", "l": "Epithelial cells.ciliated | Body fluid | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Epithelial cells.ciliated | Body fluid | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4511891", "l": "Population of all plasma cells in portion of fluid", "d": [], "t": []}, {"i": "SNOMEDCT:726508007", "l": "", "d": [], "t": []}], "preferred_name": "Population of all plasma cells in portion of fluid", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0000978", "l": "IgM short lived plasma cell", "d": ["A short lived plasma cell that secretes IgM."], "t": []}], "preferred_name": "IgM short lived plasma cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0002399", "l": "CD1c-positive myeloid dendritic cell", "d": ["A myeloid dendritic cell that is CD1c-positive."], "t": []}], "preferred_name": "CD1c-positive myeloid dendritic cell", "taxa": []}
{"type": "biolink:Cell", "ic": 88.20185721311867, "identifiers": [{"i": "CL:0011008", "l": "embryonic hemocyte", "d": ["A hemocyte derived from the embryonic head mesoderm, which enters the hemolymph as a circulating cell."], "t": []}], "preferred_name": "embryonic hemocyte", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5177775", "l": "Polyclonal plasma cells | Bone marrow | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Polyclonal plasma cells | Bone marrow | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5154539", "l": "B-cell CD27 and IgD subsets | Blood | Cell markers", "d": [], "t": []}], "preferred_name": "B-cell CD27 and IgD subsets | Blood | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1955256", "l": "Erythrocytes.fetal", "d": [], "t": []}], "preferred_name": "Erythrocytes.fetal", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0882846", "l": "CD33+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:116825007", "l": "", "d": [], "t": []}], "preferred_name": "CD33+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4277737", "l": "Grid Cells", "d": [], "t": []}, {"i": "MESH:D000071038", "l": "Grid Cells", "d": [], "t": []}], "preferred_name": "Grid Cells", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1623039", "l": "Veiled Cells", "d": [], "t": []}, {"i": "SNOMEDCT:127942009", "l": "", "d": [], "t": []}], "preferred_name": "Veiled Cells", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "CL:0002635", "l": "nonkeratinized epithelial cell of anal column", "d": ["A nonkeratinized epithelial cell of the anal canal."], "t": []}, {"i": "UMLS:C2339159", "l": "Nonkeratinized cell of epithelium of anal column", "d": [], "t": []}], "preferred_name": "nonkeratinized epithelial cell of anal column", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5179522", "l": "Reticulocytes.high light scatter | Blood | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Reticulocytes.high light scatter | Blood | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5557242", "l": "Allogeneic Anti-BCMA CAR T Cells P-BCMA-ALLO1", "d": [], "t": []}, {"i": "NCIT:C181747", "l": "Allogeneic Anti-BCMA CAR T Cells P-BCMA-ALLO1", "d": ["An off-the-shelf (OTS) preparation composed of human allogeneic T-cells and containing primarily stem cell memory T-cells (Tscm) that are transfected by electroporation with a proprietary transposon-based DNA plasmid vector (PiggyBac; PB) encoding for an undisclosed drug selection gene encoding for a selectable marker to generate close to 100% CAR-based product, a caspase-based safety switch to reduce or eliminate the product in vivo if needed, and a B-cell maturation antigen (BCMA; tumor necrosis factor receptor superfamily member 17; TNFRSF17)-specific single domain variable heavy chain (VH) chimeric antigen receptor (CAR) (VCAR), with potential immunostimulating and antineoplastic activities. The CAR T-cells are also site specifically gene-edited with Cas-CLOVER (CC) to eliminate surface expression of both T-cell receptor (TCR) and beta-2 microglobulin (beta 2M) to decrease major histocompatibility complex (MHC) class I expression and further selected, by depletion of residual CD3-positive/TCR-positive cells, and expanded to yield Tscm enriched allogeneic transposed CAR-T cells. Upon administration, allogeneic anti-BCMA CAR T cells P-BCMA-ALLO1 specifically recognize and induce selective toxicity in BCMA-expressing tumor cells. BCMA, a tumor-specific antigen and a member of the tumor necrosis factor receptor superfamily (TNFRSF) that binds to both a proliferation-inducing ligand (APRIL; TNFSF13) and B-cell activating factor (BAFF; TNFSF13B), plays a key role in plasma cell survival. BCMA is found on the surfaces of plasma cells and is overexpressed on malignant plasma cells."], "t": []}], "preferred_name": "Allogeneic Anti-BCMA CAR T Cells P-BCMA-ALLO1", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0002304", "l": "non-pigmented ciliary epithelial cell", "d": ["A cell that is part of non-pigmented ciliary epithelium. This cell type participates in aqueous humor formation by releasing solute, principally sodium and chloride ions received from pigmented epithelial cells via gap junctions, into the aqueous humor of the eye."], "t": []}, {"i": "UMLS:C1182647", "l": "Non-pigmented ciliary epithelial cell", "d": [], "t": []}], "preferred_name": "non-pigmented ciliary epithelial cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0002519", "l": "interrenal epithelial cell", "d": ["An interrenal epithelial kidney cell is an epithelial cell found in the anterior kidney of teleosts fish. This cell type is arranged in layers around the posterior cardinal vein and contains many mitochondria with tubulovesicular cristae. Interrenal chromaffin cells are interspersed among the tissue layer created by this cell type."], "t": []}], "preferred_name": "interrenal epithelial cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1513797", "l": "Mouse Myoepitheliocyte", "d": [], "t": []}, {"i": "NCIT:C22697", "l": "Mouse Myoepitheliocyte", "d": [], "t": []}], "preferred_name": "Mouse Myoepitheliocyte", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5828578", "l": "Erythron", "d": [], "t": []}], "preferred_name": "Erythron", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4760444", "l": "Adoptive immunotherapy agent CTL019", "d": [], "t": []}], "preferred_name": "Adoptive immunotherapy agent CTL019", "taxa": []}
{"type": "biolink:Cell", "ic": 92.76600187037766, "identifiers": [{"i": "CL:4030063", "l": "L4 intratelencephalic projecting glutamatergic neuron", "d": ["A transcriptomically distinct intratelencephalic-projecting glutamatergic neuron with a soma found in cortical layer 3-4. This neuron type can have a pyramidal, star-pyramidal or spiny stellate morphology and projects its output to L2/3 and L5A/B.", "A transcriptomically distinct intratelencephalic-projecting glutamatergic neuron with a soma found in cortical layer 3-4. This neuron type can have a pyramidal, star-pyramidal or spiny stellate morphology and projects its output to L2/3 and L5A/B. The standard transcriptomic reference data for this cell type can be found on the CellxGene census under the collection: 'Transcriptomic cytoarchitecture reveals principles of human neocortex organization', dataset: 'Supercluster: IT-projecting excitatory neurons', Author Categories: 'CrossArea_subclass', L4 IT."], "t": []}], "preferred_name": "L4 intratelencephalic projecting glutamatergic neuron", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0017001", "l": "splanchnic mesodermal cell", "d": ["A mesodermal cell that is part of the splanchnic layer of lateral plate mesoderm."], "t": []}], "preferred_name": "splanchnic mesodermal cell", "taxa": []}
{"type": "biolink:Cell", "ic": 86.30756602822301, "identifiers": [{"i": "CL:0000884", "l": "mucosa-associated lymphoid tissue macrophage", "d": ["A tissue-resident macrophage found in the mucosa associated lymphoid tissue."], "t": []}], "preferred_name": "mucosa-associated lymphoid tissue macrophage", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4030010", "l": "epithelial cell of proximal tubule segment 2", "d": ["A brush border cell that is part of segment 2 (S2) of the proximal tubule epithelium, located in the renal cortex. In addition to its reabsorptive functions, it is also specialized in the secretion of organic anions and cations, including para-aminohippurate."], "t": []}], "preferred_name": "epithelial cell of proximal tubule segment 2", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C4330672", "l": "Membrane-bound Interleukin-21-Expanded Haploidentical Natural Killer Cells", "d": [], "t": []}, {"i": "NCIT:C131901", "l": "Membrane-bound Interleukin-21-Expanded Haploidentical Natural Killer Cells", "d": ["A preparation of human cytokine interleukin-21 (IL-21) primed, tumor-activated allogeneic human leukocyte antigen (HLA) haploidentical natural killer (NK) cells, with potential cytolytic and immunoregulatory activities. Allogeneic leukemia cells are genetically modified to express membrane-bound interleukin-21 (mbIL-21) on their cell surfaces. When human peripheral blood mononuclear cells (PBMCs) from an HLA-haploidentical donor are subsequently exposed to these cells, the donor PBMC differentiate into mature, highly cytotoxic NK cells, which are subsequently expanded in ex vivo culture.  Upon infusion of the mbIL-21-expanded haploidentical NK cells, the NK cells target, lyse and destroy tumor cells. mbIL-21 promotes sustained ex vivo proliferation of human NK cells and enhances its cytotoxic activity."], "t": []}], "preferred_name": "Membrane-bound Interleukin-21-Expanded Haploidentical Natural Killer Cells", "taxa": []}
{"type": "biolink:Cell", "ic": 40.14995584777031, "identifiers": [{"i": "UMLS:C1510721", "l": "Abnormal Epithelial Cell", "d": [], "t": []}, {"i": "NCIT:C36745", "l": "Abnormal Epithelial Cell", "d": ["An epithelial cell that occurs in human disease or in models of human disease."], "t": []}], "preferred_name": "Abnormal Epithelial Cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5151699", "l": "Acute leukemia markers | XXX | Cell markers", "d": [], "t": []}], "preferred_name": "Acute leukemia markers | XXX | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4030003", "l": "interstitial cell of thymus", "d": ["A cell that makes up the loose connective tissue of the thymus."], "t": []}], "preferred_name": "interstitial cell of thymus", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0228086", "l": "Glioblast", "d": [], "t": []}, {"i": "SNOMEDCT:15837001", "l": "", "d": [], "t": []}], "preferred_name": "Glioblast", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C3896657", "l": "Anti-CD3 OKT3/Humanized Anti-GD2 3F8 Bispecific Antibody-activated T Lymphocytes", "d": [], "t": []}, {"i": "NCIT:C116330", "l": "Anti-CD3 OKT3/Humanized Anti-GD2 3F8 Bispecific Antibody-activated T Lymphocytes", "d": ["Autologous activated T cells that have been coated with bispecific antibodies (BiAb) comprised of anti-CD3 murine monoclonal antibody OKT3 heteroconjugated to anti-GD2 humanized monoclonal antibody 3F8 (hu3F8), with potential antineoplastic and immunomodulating activities. In vitro, T cells are exposed to OKT3, which binds to the T cell receptor-CD3 complex on the T cell surface, crosslinks the CD3 receptors and leads to T cell activation. In turn, the hu3F8 monoclonal antibody is heteroconjugated to OKT3. Upon administration, anti-CD3 x anti-GD2 bispecific antibody-armed activated T cells attach to GD2-expressing tumor cells, thereby selectively cross-linking T cells and tumor cells. This results in selective cytotoxicity towards the GD2-expressing tumor cells. In addition, cytokine and chemokine secretion by the T cells further activates the immune system, which leads to the recruitment and activation of cytotoxic T lymphocytes (CTLs), and additional CTL-mediated tumor-specific cell lysis. GD2, a disialoganglioside and tumor-associated antigen, is overexpressed in a variety of tumor cell types. CD3 is part of the functional T cell receptor (TCR) complex, which is necessary for antigen recognition by T cells, and is required for signal transduction."], "t": []}], "preferred_name": "Anti-CD3 OKT3/Humanized Anti-GD2 3F8 Bispecific Antibody-activated T Lymphocytes", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0000389", "l": "socket cell (sensu Nematoda)", "d": [], "t": []}], "preferred_name": "socket cell (sensu Nematoda)", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1440388", "l": "Cells.G2+M phase", "d": [], "t": []}], "preferred_name": "Cells.G2+M phase", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0003032", "l": "M3-OFF retinal ganglion cell", "d": ["A monostratified retinal ganglion cell that has post synaptic terminals in sublaminar layer S2 and is depolarized by decreased illumination of their receptive field center"], "t": []}], "preferred_name": "M3-OFF retinal ganglion cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1514392", "l": "Premalignant Cell", "d": [], "t": []}, {"i": "NCIT:C12976", "l": "Premalignant Cell", "d": ["Cells which show sign/s, that they can become cancerous."], "t": []}], "preferred_name": "Premalignant Cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1267943", "l": "Lymphocyte positive for CD51 antigen", "d": [], "t": []}, {"i": "SNOMEDCT:117386007", "l": "", "d": [], "t": []}], "preferred_name": "Lymphocyte positive for CD51 antigen", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5940078", "l": "Leukocytes | Urine | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Leukocytes | Urine | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": 83.11065783093733, "identifiers": [{"i": "CL:0007010", "l": "preosteoblast", "d": ["Skeletogenic cell that has the potential to transform into an osteoblast, and develops from neural crest or mesodermal cells."], "t": []}], "preferred_name": "preosteoblast", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0002366", "l": "myometrial cell", "d": ["A smooth muscle cell of the myometrium that enlarges and stretches during pregnancy, and contracts in response to oxytocin."], "t": []}], "preferred_name": "myometrial cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:1000482", "l": "myocardial endocrine cell of interventricular septum", "d": ["A myocardial endocrine cell that is part of the interventricular septum."], "t": []}, {"i": "UMLS:C2328882", "l": "Myocardial endocrine cell of interventricular septum", "d": [], "t": []}], "preferred_name": "myocardial endocrine cell of interventricular septum", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5157368", "l": "CD2 cells | Blood | Cell markers", "d": [], "t": []}], "preferred_name": "CD2 cells | Blood | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": 76.78008365410358, "identifiers": [{"i": "CL:0002138", "l": "endothelial cell of lymphatic vessel", "d": ["A endothelial cell of a lymphatic vessel. The border of the oak leaf-shaped endothelial cell of initial lymphatics are joined by specialized buttons. The discontinuous feature of buttons distinguishes them from zippers in collecting lymphatics, but both types of junctions are composed of proteins typical of adherens junctions and tight junctions found in the endothelium of blood vessels. Buttons seal the sides of flaps of the oak leaf-shaped endothelial cell, leaving open the tips of flaps as routes for fluid entry without disassembly and reformation of intercellular junctions."], "t": []}, {"i": "UMLS:C1180795", "l": "Endothelial cell of lymphatic vessel", "d": [], "t": []}], "preferred_name": "endothelial cell of lymphatic vessel", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5382576", "l": "Cells.CD8.PMA+ionomycin stimulated gamma interferon producing", "d": [], "t": []}], "preferred_name": "Cells.CD8.PMA+ionomycin stimulated gamma interferon producing", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5157393", "l": "CD22 blasts | Blood | Cell markers", "d": [], "t": []}], "preferred_name": "CD22 blasts | Blood | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": 79.35380886648232, "identifiers": [{"i": "CL:0002085", "l": "tanycyte", "d": ["A specialized elongated ventricular ependymal cell with one or more processes that extend into the brain parenchyma or associated blood vessels where they contact blood vessel endothelial cells and/or neurons. These cells are found in the ventricles and circumventricular organs of the brain. They are involved in hormonal regulation, gatekeeping molecules between the bloodstream and cerebrospinal fluid, metabolic sensing, and regulating food intake."], "t": []}, {"i": "UMLS:C2330982", "l": "Tanycytes", "d": [], "t": []}], "preferred_name": "tanycyte", "taxa": []}
{"type": "biolink:Cell", "ic": 84.83823963392128, "identifiers": [{"i": "UMLS:C1709673", "l": "Primitive Malignant Skeletal Spindle Cell", "d": [], "t": []}, {"i": "NCIT:C49201", "l": "Primitive Malignant Skeletal Spindle Cell", "d": [], "t": []}], "preferred_name": "Primitive Malignant Skeletal Spindle Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1518752", "l": "Mouse Ovarian Interstitial Cell", "d": [], "t": []}, {"i": "NCIT:C22663", "l": "Mouse Ovarian Interstitial Cell", "d": [], "t": []}], "preferred_name": "Mouse Ovarian Interstitial Cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0486534", "l": "Cells other than spermatozoa", "d": [], "t": []}], "preferred_name": "Cells other than spermatozoa", "taxa": []}
{"type": "biolink:Cell", "ic": 77.60424150429895, "identifiers": [{"i": "CL:0002073", "l": "transitional myocyte", "d": ["Specialized cardiac myocyte which is in the internodal tract and atrioventricular node. The cell is more slender than ordinary atrial myocytes and has more myofibrils than nodal myocytes."], "t": []}, {"i": "UMLS:C1179892", "l": "Transitional myocyte", "d": [], "t": []}], "preferred_name": "transitional myocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5854468", "l": "Autologous TP53 R175H Mutant-specific HLA-A*02:01-restricted TCR Gene Engineered T-lymphocytes NT-175", "d": [], "t": []}, {"i": "NCIT:C200071", "l": "Autologous TP53 R175H Mutant-specific HLA-A*02:01-restricted TCR Gene Engineered T-lymphocytes NT-175", "d": ["A preparation of autologous T-lymphocytes that have been genetically modified to express a T-cell receptor (TCR) specific for the human leukocyte antigen (HLA)-A*02:01-restricted TP53 (p53) R175H mutant, with potential antineoplastic activity. Upon isolation, transduction, expansion ex vivo and re-introduction into the patient, the autologous TP53 R175H mutant-specific HLA-A*02:01-restricted TCR gene engineered T-lymphocytes NT-175 target and bind to tumor cells expressing the TP53 R175H mutant. This may lead to cytotoxic T-lymphocyte (CTL)-mediated elimination of tumor cells expressing the TP53 R175H mutant. p53, a tumor suppressor gene, is mutated in many tumor cells, resulting in the loss of apoptosis regulation and abnormal cell proliferation."], "t": []}], "preferred_name": "Autologous TP53 R175H Mutant-specific HLA-A*02:01-restricted TCR Gene Engineered T-lymphocytes NT-175", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4304496", "l": "Population of all sickle cells in portion of fluid", "d": [], "t": []}, {"i": "SNOMEDCT:719692009", "l": "", "d": [], "t": []}], "preferred_name": "Population of all sickle cells in portion of fluid", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5237177", "l": "Autologous gamma-globinG16D/sh RNA734 Gene-transduced CD34-positive Cells CSL200", "d": [], "t": []}, {"i": "NCIT:C165434", "l": "Autologous gamma-globinG16D/sh RNA734 Gene-transduced CD34-positive Cells CSL200", "d": ["A preparation of autologous, CD34-positive hematopoietic stem cells (HSCs) transduced ex vivo with a lentiviral vector encoding for an engineered form of human gamma-globin (hemoglobin-gamma) gene, gamma-globin G16D, and a short-hairpin (sh) RNA734, with potential to restore gamma-globin expression and function. Autologous CD34-positive stem cells are isolated from the patient's own bone marrow and the cells are transduced with the lentiviral vector. Upon re-infusion of the CD34-positive cells back into the patient, these cells express gamma-globinG16D, thereby replacing defective beta globin chains with gamma globin chains allowing the body to make fetal hemoglobin (HbF) and thus healthy red blood cells with a greater oxygen-carrying capacity. Gamma-globin comprises the gamma-chain of HbF; reactivation of HbF in disorders where beta-globin is defective in adult hemoglobin (HbA), such as sickle cell disease and beta thalassemia, may ameliorate these conditions. The G16D form of gamma-globin has increased anti-sickling activity compared to the wild type protein. The shRNA734 is used for positive gene selection."], "t": []}], "preferred_name": "Autologous gamma-globinG16D/sh RNA734 Gene-transduced CD34-positive Cells CSL200", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5206711", "l": "Chimeric Costimulatory Converting Receptor-modified NK-92 Cells", "d": [], "t": []}, {"i": "NCIT:C162637", "l": "Chimeric Costimulatory Converting Receptor-modified NK-92 Cells", "d": ["A preparation of genetically-modified natural killer (NK) cells derived from the allogeneic NK-92 cell line that are transduced with an as of yet unspecified chimeric costimulatory converting receptor (CCCR) for cancer retargeting purposes, with potential cytolytic, immunomodulating and antineoplastic activities. Upon infusion of the CCCR-modified NK-92 cells, the redirected NK cells recognize and bind to tumor cells. This leads to the secretion and release of perforins, granzymes, cytokines and chemokines, which results in selective tumor cell lysis. The NK-92 cells are derived from a human cytotoxic cell line composed of allogeneic, activated, interleukin-2-(IL-2) dependent-NK cells from a 50-year old male patient with rapidly progressive non-Hodgkin's lymphoma. As NK-92 cells are devoid of killer inhibitory receptors (KIRs; also called killer cell immunoglobulin-like receptors), which are negative regulators of NK cell activity, cancer cells are unable to suppress the cancer cell killing ability of the NK-92 cells."], "t": []}], "preferred_name": "Chimeric Costimulatory Converting Receptor-modified NK-92 Cells", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5157438", "l": "CD3+CD4+ (T4 helper) cells | Tissue and Smears | Cell markers", "d": [], "t": []}], "preferred_name": "CD3+CD4+ (T4 helper) cells | Tissue and Smears | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4307047", "l": "Astro-TE NN_3 Crym astrocyte (Mmus)", "d": ["A astrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of S1pr1 (Mmus), Crym (Mmus), Grin2c (Mmus). It is distinguished from other Astro-TE NN_3 cells by expression of Crym, Gabbr2. These cells are located in the Striatum dorsal region, Striatum ventral region , in or close to the regions: Nucleus accumbens, Caudoputamen . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5227 Astro-TE NN_3."], "t": []}], "preferred_name": "Astro-TE NN_3 Crym astrocyte (Mmus)", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0000356", "l": "hair matrix stem cell", "d": [], "t": []}], "preferred_name": "hair matrix stem cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0004120", "l": "retinal ganglion cell A1", "d": ["A retinal ganglion A cell found in the retina with large somata, often polygonal in shape. The dendritic fields consist of three to seven stout dendrites that are sparce near soma. Dendrites terminate in S4."], "t": []}], "preferred_name": "retinal ganglion cell A1", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4322670", "l": "CD3+ T lymphocyte", "d": [], "t": []}], "preferred_name": "CD3+ T lymphocyte", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1440296", "l": "CD33+CD44+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:1373022007", "l": "", "d": [], "t": []}], "preferred_name": "CD33+CD44+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1979667", "l": "Cells.CD19+IgA+", "d": [], "t": []}], "preferred_name": "Cells.CD19+IgA+", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5856192", "l": "CLEC12A-targeting CCR/Anti-ADGRE2 CAR T Cells ADCLEC.syn1", "d": [], "t": []}, {"i": "NCIT:C200268", "l": "CLEC12A-targeting CCR/Anti-ADGRE2 CAR T Cells ADCLEC.syn1", "d": ["A preparation of T-lymphocytes that have been genetically modified to express a chimeric antigen receptor (CAR) specific for the human myeloid-restricted adhesion G protein-coupled receptor E2 (ADGRE2; EGF-like module receptor 2; EMR2; CD312), and a chimeric costimulatory receptor (CCR) targeting C-type lectin domain family 12 member A (CLEC12A, C-type-lectin-like molecule-1; CLL-1; CLL1), with potential immunomodulating and antineoplastic activities. Upon administration, CLEC12A-targeting CCR/anti-ADGRE2 CAR T cells ADCLEC.syn1 target and bind to ADGRE2- and CLEC12A-expressing tumor cells. This induces selective toxicity in tumor cells that express a high level of ADGRE2, and tumor cells that express both ADGRE2 and CLEC12A. ADGRE2 is expressed mainly on myeloid cells and is overexpressed on leukemic stem cells (LSCs) in acute myeloid leukemia (AML). CLEC12A, a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily, is overexpressed on LSCs and plays an important role in disease progression and relapse for myeloid malignancies. ADGRE2 and CLEC12A are highly co-expressed in AML and not in normal tissues. Targeting both ADGRE2 and CLEC12A may improve efficacy and reduce adverse effects."], "t": []}], "preferred_name": "CLEC12A-targeting CCR/Anti-ADGRE2 CAR T Cells ADCLEC.syn1", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "UMLS:C1709162", "l": "Neoplastic Adrenal Cortical Clear Cell", "d": [], "t": []}, {"i": "NCIT:C48362", "l": "Neoplastic Adrenal Cortical Clear Cell", "d": [], "t": []}], "preferred_name": "Neoplastic Adrenal Cortical Clear Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 92.76600187037766, "identifiers": [{"i": "CL:0000318", "l": "sweat secreting cell", "d": ["A cell secreting sweat, the fluid excreted by the sweat glands of mammals. It consists of water containing sodium chloride, phosphate, urea, ammonia, and other waste products."], "t": []}], "preferred_name": "sweat secreting cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1510929", "l": "Autologous Anti-MART-1 F5 T-Cell Receptor Gene-Engineered Peripheral Blood Lymphocytes", "d": [], "t": []}, {"i": "NCIT:C38587", "l": "Autologous Anti-MART-1 F5 T-Cell Receptor Gene-Engineered Peripheral Blood Lymphocytes", "d": ["Human autologous peripheral blood lymphocytes (PBLs) transduced with a melanoma antigen MART-1 epitope-determined T cell receptor (TCR) gene, with potential antineoplastic activity. PBLs are isolated from a melanoma patient and pulsed with a viral vector that encodes the TCR specific for an epitope of MART-1 (F5 TCR). After expansion ex vivo, the transduced autologous PBLs, expressing this specific TCR, are reintroduced into the patient, and bind to melanoma cells expressing the MART-1 antigen, which may result in specific cytotoxic T-lymphocyte (CTL) killing of MART-1-expressing melanoma cells. MART-1 (melanoma antigen recognized by T cells 1), also known as Melan-A, is a melanocyte lineage-specific transmembrane protein."], "t": []}], "preferred_name": "Autologous Anti-MART-1 F5 T-Cell Receptor Gene-Engineered Peripheral Blood Lymphocytes", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4072010", "l": "A13 dopaminergic neuron", "d": ["A type of dopaminergic neuron located in the rostro-medial part of the zona incerta. It is involved in nociception and prehensile movement."], "t": []}], "preferred_name": "A13 dopaminergic neuron", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4023094", "l": "tufted pyramidal neuron", "d": ["A pyramidal neuron which has a distinctive tuft formation, distal from the soma."], "t": []}], "preferred_name": "tufted pyramidal neuron", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4738963", "l": "Leukocytes.DNA+Plasma.cfDNA", "d": [], "t": []}], "preferred_name": "Leukocytes.DNA+Plasma.cfDNA", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5157426", "l": "CD3 cells | Cerebral spinal fluid | Cell markers", "d": [], "t": []}], "preferred_name": "CD3 cells | Cerebral spinal fluid | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5419440", "l": "Autologous Anti-CD20 CAR Transduced CD4/CD8 Enriched T-cells MB-CART20.1", "d": [], "t": []}, {"i": "NCIT:C172063", "l": "Autologous Anti-CD20 CAR Transduced CD4/CD8 Enriched T-cells MB-CART20.1", "d": ["A preparation of autologous T-lymphocytes that have been genetically modified to express a chimeric antigen receptor (CAR) targeting the tumor-associated antigen (TAA) CD20 (cluster of differentiation 20), and CD4/CD8 enriched, with potential immunostimulating and antineoplastic activities. Upon administration, MB-CART20.1 specifically recognize and kill CD20-expressing tumor cells. The CD20 antigen, a non-glycosylated cell surface phosphoprotein, is a B-cell specific cell surface antigen expressed in B-cell lineage malignancies and certain melanoma cell subpopulations."], "t": []}], "preferred_name": "Autologous Anti-CD20 CAR Transduced CD4/CD8 Enriched T-cells MB-CART20.1", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0684104", "l": "glomerul(o)", "d": [], "t": []}], "preferred_name": "glomerul(o)", "taxa": []}
{"type": "biolink:Cell", "ic": 84.83823963392128, "identifiers": [{"i": "UMLS:C1514036", "l": "Neoplastic Myeloblast with Azurophilic Granules", "d": [], "t": []}, {"i": "NCIT:C37178", "l": "Neoplastic Myeloblast with Azurophilic Granules", "d": [], "t": []}], "preferred_name": "Neoplastic Myeloblast with Azurophilic Granules", "taxa": []}
{"type": "biolink:Cell", "ic": 56.45305485866055, "identifiers": [{"i": "UMLS:C0038250", "l": "Stem cells", "d": [], "t": []}, {"i": "NCIT:C12662", "l": "Stem Cell", "d": ["An unspecialized cell that has the capacity for reproduction through cell division and can be induced to differentiate into a tissue or organ specific cell."], "t": []}, {"i": "MESH:D013234", "l": "Stem Cells", "d": [], "t": []}, {"i": "SNOMEDCT:419758009", "l": "", "d": [], "t": []}], "preferred_name": "Stem cells", "taxa": []}
{"type": "biolink:Cell", "ic": 92.76600187037766, "identifiers": [{"i": "CL:4030019", "l": "kidney connecting tubule intercalated cell", "d": ["A renal intercalated cell that is part of the renal connecting tubule."], "t": []}], "preferred_name": "kidney connecting tubule intercalated cell", "taxa": []}
{"type": "biolink:Cell", "ic": 89.40238429118027, "identifiers": [{"i": "CL:0002324", "l": "basal-myoepithelial cell of mammary gland", "d": ["A myoepithelial cell that is part of a mammary gland and is located in the basal layer. During lactation, a basal-myoepithelial cell of mammary gland contracts under the stimulation of oxytocin. In humans, a basal-myoepithelial cell of mammary gland can be identified by high levels of CD49f and low levels of EpCAM."], "t": []}, {"i": "UMLS:C1180269", "l": "Myoepithelial cell of lactiferous gland", "d": [], "t": []}], "preferred_name": "basal-myoepithelial cell of mammary gland", "taxa": []}
{"type": "biolink:Cell", "ic": 62.290603953736586, "identifiers": [{"i": "CL:4042039", "l": "caudal ganglionic eminence derived neuron", "d": ["A neuron of the central nervous system that develops from a caudal ganglionic eminence."], "t": []}], "preferred_name": "caudal ganglionic eminence derived neuron", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1519712", "l": "Type III Epithelial Receptor Cell", "d": [], "t": []}, {"i": "NCIT:C13149", "l": "Type III Epithelial Receptor Cell", "d": ["A light cell found in taste buds, characterized by afferent synaptic specializations to intragemminal nerve endings including increased density of the plasma membrane along the nerve and aggregations of synaptic vesicles, and by the presence of cored vesicles of 80-150 nm in diameter. The core is dense and the cell is immunoreactive for 5-hydroxytryptamine, neural cell adhesion molecule, and PGP 9.5."], "t": []}], "preferred_name": "Type III Epithelial Receptor Cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4323727", "l": "Cardiac neural crest cell", "d": [], "t": []}], "preferred_name": "Cardiac neural crest cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4033093", "l": "limbal epithelial stem cell of cornea", "d": ["A stem cell that is part of the corneo-scleral limbus. This cell type resides at the basal layer of the epithelium and has a small size and high nuclear to cytoplasmatic ratio (Secker and Daniels, 2009). A limbal stem cell is responsible for corneal epithelial renewal and repair (Li et al., 2023), and to help maintain a clear corneal surface by preventing conjunctival epithelial cells from migrating onto the cornea (Wang et al., 2023)."], "t": []}], "preferred_name": "limbal epithelial stem cell of cornea", "taxa": []}
{"type": "biolink:Cell", "ic": 71.74874531021723, "identifiers": [{"i": "CL:0000805", "l": "immature single positive thymocyte", "d": ["A thymocyte that has the phenotype CD4-negative, CD8-positive, CD44-negative, CD25-negative, and pre-TCR-positive."], "t": []}], "preferred_name": "immature single positive thymocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0009003", "l": "larval midgut cell", "d": ["Any cell in the midgut (middle subdivision of a digestive tract) of an insect larva."], "t": []}], "preferred_name": "larval midgut cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1441343", "l": "100 lymphocytes", "d": [], "t": []}], "preferred_name": "100 lymphocytes", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4307048", "l": "Astro-TE NN_4 astrocyte (Mmus)", "d": ["A astrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of S1pr1 (Mmus), Thbs4 (Mmus), Gm29683 (Mmus), Slc39a12 (Mmus). It is distinguished from other Astro-TE NN cells by expression of Gm29683. These cells are located in the Cortical subplate, brain , in or close to the regions: Lateral amygdalar nucleus, external capsule . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5228 Astro-TE NN_4."], "t": []}], "preferred_name": "Astro-TE NN_4 astrocyte (Mmus)", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5205544", "l": "Autologous Anti-CD19/Anti-CD20-CAR-CD28-4-1BB-CD3zeta-EGFRt+-expressing Tn/mem Cells", "d": [], "t": []}, {"i": "NCIT:C160777", "l": "Autologous Anti-CD19/Anti-CD20-CAR-CD28-4-1BB-CD3zeta-EGFRt+-expressing Tn/mem Cells", "d": ["A preparation of genetically modified autologous naive/memory T-cells (Tn/mem),  that have been transduced with a self-inactivating (SIN) lentiviral vector to express a bispecific chimeric antigen receptor (CAR) consisting of a single chain variable fragment (scFv) of anti-CD19, derived from the anti-CD19 monoclonal antibody FMC63, in tandem with an anti-CD20 scFv, derived from the anti-CD20 monoclonal antibody Leu16, and fused to the hinge domain of human immunoglobulin (Ig) G4, the transmembrane domain of human CD28, and the cytoplasmic signaling domains of 4-1BB (CD137) and the T-cell antigen receptor complex zeta chain (CD3-zeta) (BBz), and linked via the T2A sequence to a truncated form of the human epidermal growth factor receptor (EGFRt), with potential immunostimulating and antineoplastic activities. Upon transfusion, autologous anti-CD19/anti-CD20-CAR-CD28-4-1BB-CD3zeta-EGFR+-expressing Tn/mem cells recognize and induce selective toxicity in CD19/CD20-expressing tumor cells, resulting in tumor cell lysis. Both CD19 and CD20 are B-cell-specific cell surface antigens overexpressed in B-cell lineage malignancies. Devoid of both ligand binding domains and tyrosine kinase activity, EGFRt both facilitates in vivo detection of the administered T-cells and can promote elimination of those cells upon a cetuximab-induced antibody dependent cellular cytotoxicity (ADCC) response."], "t": []}], "preferred_name": "Autologous Anti-CD19/Anti-CD20-CAR-CD28-4-1BB-CD3zeta-EGFRt+-expressing Tn/mem Cells", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4072767", "l": "Cells.4q12 chromosome region rearrangements", "d": [], "t": []}], "preferred_name": "Cells.4q12 chromosome region rearrangements", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5216222", "l": "Hairy cells|NCnc|Pt|Bld", "d": [], "t": []}], "preferred_name": "Hairy cells|NCnc|Pt|Bld", "taxa": []}
{"type": "biolink:Cell", "ic": 88.20185721311867, "identifiers": [{"i": "CL:0000307", "l": "tracheal epithelial cell", "d": ["An epithelial cell found in the trachea."], "t": []}, {"i": "UMLS:C1184310", "l": "Epithelial cell of trachea", "d": [], "t": []}], "preferred_name": "tracheal epithelial cell", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "CL:4023005", "l": "dynamic nuclear bag fiber", "d": ["A nuclear bag fiber that is sensitive mainly to the rate of change in muscle length."], "t": []}], "preferred_name": "dynamic nuclear bag fiber", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C2328087", "l": "Paravertebral ganglion neuron", "d": [], "t": []}], "preferred_name": "Paravertebral ganglion neuron", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0000699", "l": "paraganglial type 1 cell", "d": ["A type of glomus or chief cell, is sensitive to hypoxia and produce catecholamines."], "t": []}], "preferred_name": "paraganglial type 1 cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C4725073", "l": "Autologous CD5-specific CAR-28 zeta CAR T-cells", "d": [], "t": []}, {"i": "NCIT:C148490", "l": "Autologous CD5-specific CAR-28 zeta CAR T-cells", "d": ["Autologous T-lymphocytes transduced with a retroviral vector expressing a chimeric antigen receptor (CAR) consisting of an anti-CD5 single chain variable fragment (scFv) coupled to the costimulatory signaling domain CD28 and the zeta chain of the T-cell receptor (TCR), with potential immunomodulating and antineoplastic activities. Upon transfusion, the autologous CD5-specific CAR-28 zeta CAR T-cells are directed to and induce selective toxicity in CD5-expressing tumor cells. The tumor-associated antigen (TAA) CD5 is a T-cell surface glycoprotein expressed on the surface of normal T-cells, and is overexpressed on various B- and T-cell malignancies; its expression is associated with poor prognosis."], "t": []}], "preferred_name": "Autologous CD5-specific CAR-28 zeta CAR T-cells", "taxa": []}
{"type": "biolink:Cell", "ic": 63.160678181670086, "identifiers": [{"i": "UMLS:C1708878", "l": "Malignant Germ Cell", "d": [], "t": []}, {"i": "NCIT:C54110", "l": "Malignant Germ Cell", "d": [], "t": []}], "preferred_name": "Malignant Germ Cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4240447", "l": "Vascular smooth muscle cell of abdominal aorta", "d": [], "t": []}], "preferred_name": "Vascular smooth muscle cell of abdominal aorta", "taxa": []}
{"type": "biolink:Cell", "ic": 90.871710685482, "identifiers": [{"i": "CL:1001569", "l": "hippocampal interneuron", "d": ["An interneuron with a soma found in the hippocampus."], "t": []}, {"i": "UMLS:C2328960", "l": "Hippocampal interneuron", "d": [], "t": []}], "preferred_name": "hippocampal interneuron", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5157923", "l": "Cells | Peritoneal fluid | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Cells | Peritoneal fluid | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4510917", "l": "Blast cell with terminal deoxyribonucleotidyl transferase", "d": [], "t": []}, {"i": "SNOMEDCT:724317009", "l": "", "d": [], "t": []}], "preferred_name": "Blast cell with terminal deoxyribonucleotidyl transferase", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0947505", "l": "CD30+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:1372870007", "l": "", "d": [], "t": []}], "preferred_name": "CD30+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0009007", "l": "gastrointestinal tract (lamina propria) macrophage of small intestine", "d": ["A macrophage which is resident in the lamina propria of the small intestine."], "t": []}], "preferred_name": "gastrointestinal tract (lamina propria) macrophage of small intestine", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0002281", "l": "type S enteroendocrine cell", "d": ["Scattered in duodenojejunal mucosa, this enteroendocrine cell secretes secretin and serotonin."], "t": []}, {"i": "UMLS:C2327878", "l": "Type S enteroendocrine cell", "d": [], "t": []}], "preferred_name": "type S enteroendocrine cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4047001", "l": "cycling stromal cell", "d": ["A(n) stromal cell that is cycling."], "t": []}], "preferred_name": "cycling stromal cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1440313", "l": "CD44R+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:1372912006", "l": "", "d": [], "t": []}], "preferred_name": "CD44R+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5556445", "l": "Autologous Anti-MART-1 F5 TCR Tumor Infiltrating Lymphocytes", "d": [], "t": []}, {"i": "NCIT:C180529", "l": "Autologous Anti-MART-1 F5 TCR Tumor Infiltrating Lymphocytes", "d": ["A preparation of human tumor infiltrating lymphocytes (TILs) isolated from a melanoma patient and engineered to encode a T-cell receptor (TCR) specific for an epitope of MART-1 (F5 TCR), with potential immunomodulating and antineoplastic activities. Upon administration, the autologous anti-MART-1 F5 TCR TILs may recognize and halt the growth of MART-1-expressing melanoma cells."], "t": []}], "preferred_name": "Autologous Anti-MART-1 F5 TCR Tumor Infiltrating Lymphocytes", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4033020", "l": "mucus secreting cell of trachea gland", "d": ["A mucus secreting cell that is part of a submucosal gland of the trachea."], "t": []}], "preferred_name": "mucus secreting cell of trachea gland", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1148326", "l": "CD25 cells", "d": [], "t": []}, {"i": "SNOMEDCT:1372866004", "l": "", "d": [], "t": []}], "preferred_name": "CD25 cells", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5175605", "l": "Other cells | Cerebral spinal fluid | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Other cells | Cerebral spinal fluid | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5171674", "l": "Lymphocytes clefted | Blood or Tissue | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Lymphocytes clefted | Blood or Tissue | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1520106", "l": "Wisconsin H14 stem cell line", "d": [], "t": []}, {"i": "NCIT:C20312", "l": "WA14", "d": ["Provider: Wisconsin Alumni Research Foundation (WARF), Madison, WI. Information from provider and not independently verified by NIH: Cells are positive for cell markers SSEA-3, SSEA-4, TRA-1-60, TRA-1-81, and alkaline phosphatase; Cells are negative for SSEA-1. Give rise to teratomas containing derivatives of three germ layers in SCID mice; Differentiate in vitro; Cells not yet ready for distribution. Publication: Thomson et al., Science 282, 1145, 1998. This cell line meets the criteria for the use of human embryonic stem cells by federally funded researchers."], "t": []}], "preferred_name": "Wisconsin H14 stem cell line", "taxa": []}
{"type": "biolink:Cell", "ic": 70.01422862627324, "identifiers": [{"i": "CL:0008024", "l": "pancreatic endocrine cell", "d": ["An endocrine cell that is part of the pancreas."], "t": []}], "preferred_name": "pancreatic endocrine cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4518177", "l": "Population of all cleft lymphocytes in portion of fluid", "d": [], "t": []}, {"i": "SNOMEDCT:726766006", "l": "", "d": [], "t": []}], "preferred_name": "Population of all cleft lymphocytes in portion of fluid", "taxa": []}
{"type": "biolink:Cell", "ic": 82.62268137420203, "identifiers": [{"i": "CL:0002543", "l": "vein endothelial cell", "d": ["An endothelial cell that is part of the vein."], "t": []}, {"i": "UMLS:C1179017", "l": "Endothelial cell of vein", "d": [], "t": []}], "preferred_name": "vein endothelial cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4510887", "l": "Blast cell positive for CD126 antigen", "d": [], "t": []}, {"i": "SNOMEDCT:724305007", "l": "", "d": [], "t": []}], "preferred_name": "Blast cell positive for CD126 antigen", "taxa": []}
{"type": "biolink:Cell", "ic": 89.40238429118027, "identifiers": [{"i": "CL:1001561", "l": "vomeronasal sensory neuron", "d": ["Chemosensitive cells that innervate the vomernasal organ epithelium and are responsible for receiving and transmitting pheromone signals."], "t": []}], "preferred_name": "vomeronasal sensory neuron", "taxa": []}
{"type": "biolink:Cell", "ic": 92.76600187037766, "identifiers": [{"i": "UMLS:C1522109", "l": "Mouse B-Lymphocyte", "d": [], "t": []}, {"i": "NCIT:C22576", "l": "Mouse B-Lymphocyte", "d": [], "t": []}], "preferred_name": "Mouse B-Lymphocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4033148", "l": "nodose ganglion TRPV1 neuron", "d": ["A sensory neuron that has the soma located in the nodose ganglion and expresses the marker transient receptor potential vanilloid 1 (TRPV1)."], "t": []}], "preferred_name": "nodose ganglion TRPV1 neuron", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5707294", "l": "Autologous CXCR2-modified CD70 CAR T-cells", "d": [], "t": []}, {"i": "NCIT:C187688", "l": "Autologous CXCR2-modified CD70 CAR T-cells", "d": ["A preparation composed of ex-vivo expanded CXC chemokine receptor 2 (CXCR2) modified patient-derived activated CD70 (CD27 ligand; tumor necrosis factor superfamily member 7; TNFSF7) chimeric antigen receptor (CAR) (8R-70CAR) T-cells, with potential immunostimulating and antineoplastic activities. Upon administration of the autologous CXCR2-modified CD70 CAR T-cells, the anti-CD70-CARs on the T-cell surfaces target and bind to the CD70 antigen on tumor cell surfaces. This induces a cytotoxic T-lymphocyte (CTL)-mediated immune response against CD70-expressing tumor cells. CD70, a cytokine belonging to the tumor necrosis factor superfamily (TNFSF) and the ligand for the costimulatory receptor CD27, is expressed on the surfaces of various types of cancer cells; its overexpression may play an important role in the evasion of immune surveillance. CXCR2, a transmembrane protein also known as interleukin (IL)-8 receptor B (IL-8RB), plays a key role in inflammation and cancer progression. Certain CXCR2 ligands, such as CXCL1 and CXCL8 (IL-8), are expressed by tumor cells. CXCR2-modified CARs enhance intratumoral T-cell trafficking toward tumor cells and promotes persistence of T-cells. This may enhance the T-cell-mediated immune response against the CD70-expressing tumor cells."], "t": []}], "preferred_name": "Autologous CXCR2-modified CD70 CAR T-cells", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1440049", "l": "Abnormal blood cells.CD13", "d": [], "t": []}], "preferred_name": "Abnormal blood cells.CD13", "taxa": []}
{"type": "biolink:Cell", "ic": 77.38833137893549, "identifiers": [{"i": "CL:0000819", "l": "B-1 B cell", "d": ["A B cell of distinct lineage and surface marker expression. B-1 B cells are thought to be the primary source of natural IgM immunoglobulin, that is, IgM produced in large quantities without prior antigenic stimulation and generally reactive against various microorganisms, as well as the source of T-independent IgA immunoglobulin in the mucosal areas. These cells are CD43-positive."], "t": []}], "preferred_name": "B-1 B cell", "taxa": []}
{"type": "biolink:Cell", "ic": 90.871710685482, "identifiers": [{"i": "CL:1001505", "l": "parvocellular neurosecretory cell", "d": ["The secretory neurons of the paraventricular nucleus that synthesize and secrete vasopressin, corticotropin-releasing factor (CRF) and thyrotropin-releasing hormone (TRH) into blood vessels in the hypothalamo-pituitary portal system."], "t": []}], "preferred_name": "parvocellular neurosecretory cell", "taxa": []}
{"type": "biolink:Cell", "ic": 57.989005789614644, "identifiers": [{"i": "CL:0000223", "l": "endodermal cell", "d": ["A cell of the inner of the three germ layers of the embryo."], "t": []}, {"i": "UMLS:C1183500", "l": "Endodermal cell", "d": [], "t": []}, {"i": "NCIT:C33932", "l": "Endoderm Cell", "d": ["An embryonic cell of the inner layer of three germ layers that forms the yolk sac and gives rise to the epithelium of the alimentary and respiratory tracts and the parenchyma of associated glands."], "t": []}], "preferred_name": "endodermal cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C3828361", "l": "Recent Thymic Emigrant", "d": [], "t": []}, {"i": "NCIT:C112039", "l": "Recent Thymic Emigrant", "d": ["A T-lymphocyte that has completed intrathymic development and has exited the thymus. These cells are the youngest peripheral T-lymphocytes and migrate to secondary lymphoid organs where they slowly mature to become naive T-cells."], "t": []}], "preferred_name": "Recent Thymic Emigrant", "taxa": []}
{"type": "biolink:Cell", "ic": 92.76600187037766, "identifiers": [{"i": "UMLS:C1513528", "l": "Mouse Cell Line", "d": [], "t": []}, {"i": "NCIT:C20220", "l": "Mouse Cell Line", "d": [], "t": []}], "preferred_name": "Mouse Cell Line", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0178813", "l": "protoplast/spheroplast", "d": [], "t": []}], "preferred_name": "protoplast/spheroplast", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4052009", "l": "crypt-top fibroblast", "d": ["A subepithelial intestinal fibroblast that is located adjacent to the top of the crypt of Lieberkuhn. Characterized by high experession of PDGFRα, this cell secretes a range of signaling factors, including WNTs and BMPs, that drive epithelial differentiation, creating a gradient that regulates the balance between stem cell maintenance and differentiation."], "t": []}], "preferred_name": "crypt-top fibroblast", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C3900058", "l": "Allogeneic Multivirus-specific Cytotoxic T Lymphocytes", "d": [], "t": []}, {"i": "NCIT:C115107", "l": "Allogeneic Multivirus-specific Cytotoxic T Lymphocytes", "d": ["A population of closely human leukocyte antigen (HLA)-matched, donor-derived cytotoxic T lymphocytes (CTLs) that are specifically reactive towards five viruses, Epstein-Barr virus (EBV), cytomegalovirus (CMV), adenovirus (AdV), human herpesvirus 6 (HHV6), and human polyomavirus type I (BKV), with potential antiviral activity. Infusion of the multivirus-specific CTLs into allogeneic hematopoietic stem cell transplant (HSCT) recipients provides virus-specific cellular immunity and causes specific anti-viral effects against active viral infections. The administered CTLs also prevent EBV, CMV, AdV, HHV6, and BKV reactivation and infection as well as inhibiting viral-associated diseases in immunocompromised patients. The allogeneic multivirus-specific CTLs may also provide cellular immunity towards the human polyomavirus type II (JC virus; JCV), which is highly homologous to BKV."], "t": []}], "preferred_name": "Allogeneic Multivirus-specific Cytotoxic T Lymphocytes", "taxa": []}
{"type": "biolink:Cell", "ic": 85.53200374075534, "identifiers": [{"i": "CL:4023010", "l": "alpha7 GABAergic cortical interneuron (Mmus)", "d": ["A GABAergic cortical interneuron that is strongly labelled for α7 nAChRs. These cells have soma found in L1 and have multipolar dendrites with vertically descending axonal collaterals that project deep into the column, usually branching and terminating in L5A."], "t": []}], "preferred_name": "alpha7 GABAergic cortical interneuron (Mmus)", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:2000067", "l": "cardiac atrium fibroblast", "d": ["Any fibroblast that is part of a cardiac atrium."], "t": []}], "preferred_name": "cardiac atrium fibroblast", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C2736184", "l": "CD55+CD59+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:1373043008", "l": "", "d": [], "t": []}], "preferred_name": "CD55+CD59+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0002146", "l": "clear cell of eccrine sweat gland", "d": ["A sweat producing cell of eccrine sweat glands. Pyramidal in shape, with its base resting on the basal lamina or myoepitheliocytes, and its microvillus-covered apical plasma membrane line up the intercellular canaliculi. Cell is not stained by hematoxylin or eosin."], "t": []}, {"i": "UMLS:C1182692", "l": "Clear cell of eccrine sweat gland", "d": [], "t": []}], "preferred_name": "clear cell of eccrine sweat gland", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5158561", "l": "Cells.CD4-CD8-CD45R+TCR alpha beta+ | Blood | Cell markers", "d": [], "t": []}], "preferred_name": "Cells.CD4-CD8-CD45R+TCR alpha beta+ | Blood | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1267903", "l": "Lymphocyte positive for CD30 antigen", "d": [], "t": []}, {"i": "SNOMEDCT:117574005", "l": "", "d": [], "t": []}], "preferred_name": "Lymphocyte positive for CD30 antigen", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:1000344", "l": "paneth cell of epithelium proper of small intestine", "d": ["A Paneth cell that is part of the epithelium proper of small intestine."], "t": []}, {"i": "UMLS:C2334307", "l": "Paneth cell of epithelium proper of small intestine", "d": [], "t": []}], "preferred_name": "paneth cell of epithelium proper of small intestine", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1440287", "l": "CD3+CD8+CD45RA-CD45RO+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:1373267007", "l": "", "d": [], "t": []}], "preferred_name": "CD3+CD8+CD45RA-CD45RO+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": 82.16838616155795, "identifiers": [{"i": "UMLS:C1514181", "l": "Pleomorphic T-Lymphocyte", "d": [], "t": []}, {"i": "NCIT:C36997", "l": "Pleomorphic T-Lymphocyte", "d": [], "t": []}], "preferred_name": "Pleomorphic T-Lymphocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4307070", "l": "beta-2 tanycyte (Mmus)", "d": ["A beta2-tanycyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Fndc3c1 (Mmus), Ecrg4 (Mmus). It is distinguished from other Tanycyte NN cells by expression of Ecrg4. These cells are located in the Hypothalamus, brain , in or close to the regions: Median eminence, third ventricle, Arcuate hypothalamic nucleus . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5250 Tanycyte NN_3."], "t": []}], "preferred_name": "beta-2 tanycyte (Mmus)", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0000996", "l": "mature CD11c-negative plasmacytoid dendritic cell", "d": ["Mature CD11c-negative plasmacytoid dendritic cell is a CD11c-negative plasmacytoid dendritic cell is CD80-high, CD86-high, MHCII-high and is CD83-positive."], "t": []}], "preferred_name": "mature CD11c-negative plasmacytoid dendritic cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C3870602", "l": "B cells+monocytes", "d": [], "t": []}], "preferred_name": "B cells+monocytes", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5186733", "l": "Leukocytes | Blood product unit | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Leukocytes | Blood product unit | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5780032", "l": "HUMAN CILIARY NEUROTROPHIC FACTOR", "d": [], "t": []}], "preferred_name": "HUMAN CILIARY NEUROTROPHIC FACTOR", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5834113", "l": "PLX-PAD", "d": [], "t": []}], "preferred_name": "PLX-PAD", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4726587", "l": "MDR-101", "d": [], "t": []}], "preferred_name": "MDR-101", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5447544", "l": "Autologous Gene-modified Gamma Delta T-cells", "d": [], "t": []}, {"i": "NCIT:C176993", "l": "Autologous Gene-modified Gamma Delta T-cells", "d": ["A preparation of genetically modified autologous gamma delta T-lymphocytes transduced with a lentiviral vector to encode a DNA repair enzyme, with potential immunomodulating and antineoplastic activities. Upon administration, the autologous gene-modified gamma delta T-cells secrete interferon-gamma (IFN-g) and exert direct killing of tumor cells. In addition, these cells activate the immune system to exert a cytotoxic T-lymphocyte (CTL) response against tumor cells. Gamma delta T-lymphocytes play a key role in the activation of the immune system and do not require major histocompatibility complex (MHC)-mediated antigen presentation to exert their cytotoxic effect. The transduction of gamma delta T-cells may confer resistance to alkylating chemotherapeutic agents including temozolomide and allow the use of gamma delta T-cells as an adjunct to these agents."], "t": []}], "preferred_name": "Autologous Gene-modified Gamma Delta T-cells", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5394900", "l": "Entire platelet", "d": [], "t": []}, {"i": "SNOMEDCT:836278004", "l": "", "d": [], "t": []}], "preferred_name": "Entire platelet", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:2000069", "l": "gallbladder fibroblast", "d": ["Any fibroblast that is part of a gallbladder."], "t": []}], "preferred_name": "gallbladder fibroblast", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5708221", "l": "Anti-CD19/Anti-CD79b 4SCAR-expressing Bispecific T-cells", "d": [], "t": []}, {"i": "NCIT:C189059", "l": "Anti-CD19/Anti-CD79b 4SCAR-expressing Bispecific T-cells", "d": ["A preparation of T-lymphocytes that are genetically engineered to express a fourth-generation chimeric antigen receptor (4SCAR) targeting the two tumor-associated antigens (TAAs) CD19 and B-cell antigen receptor complex-associated protein beta chain (CD79b; B-cell-specific glycoprotein B29), with potential immunostimulating and antineoplastic activities. Upon administration, the anti-CD19/anti-CD79b 4SCAR-expressing bispecific T-cells are directed to and induce selective toxicity in CD19- and CD79b-expressing tumor cells. CD19 antigen is a B-cell specific cell surface antigen expressed in all B-cell lineage malignancies. CD79b, a B cell surface antigen and critical receptor for successful B cell development, is part of the B cell receptor (BCR) signaling complex. It is widely expressed in certain subtypes of B cell lymphomas. CD19 and CD79b are expressed at high levels on tumor cells but not at significant levels on normal tissues.  Targeting two antigens may protect against antigen escape and may enhance CAR-T cell efficacy."], "t": []}], "preferred_name": "Anti-CD19/Anti-CD79b 4SCAR-expressing Bispecific T-cells", "taxa": []}
{"type": "biolink:Cell", "ic": 83.11065783093733, "identifiers": [{"i": "CL:4052028", "l": "uterine natural killer cell", "d": ["A natural killer cell that is part of the uterus, specifically within the endometrium during the non-pregnant state and in the decidua during pregnancy. This cell exhibits dynamic changes in frequency throughout the menstrual cycle, with lower levels during menstruation and a significant increase during the mid-secretory phase and early pregnancy."], "t": []}], "preferred_name": "uterine natural killer cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0000310", "l": "iron accumulating cell", "d": [], "t": []}], "preferred_name": "iron accumulating cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5419552", "l": "Buccal Cell Sample", "d": [], "t": []}, {"i": "NCIT:C172264", "l": "Buccal Cell Sample", "d": ["A sample comprised of cells collected from the inside of a subject's cheek."], "t": []}], "preferred_name": "Buccal Cell Sample", "taxa": []}
{"type": "biolink:Cell", "ic": 74.37365206292206, "identifiers": [{"i": "UMLS:C1513961", "l": "Neoplastic Epithelial Polygonal Cell", "d": [], "t": []}, {"i": "NCIT:C37036", "l": "Neoplastic Epithelial Polygonal Cell", "d": [], "t": []}], "preferred_name": "Neoplastic Epithelial Polygonal Cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5175151", "l": "Nucleated cells | Pericardial fluid | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Nucleated cells | Pericardial fluid | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": 64.42515846714339, "identifiers": [{"i": "CL:0001012", "l": "CD7-negative lymphoid progenitor OR granulocyte monocyte progenitor", "d": [], "t": []}], "preferred_name": "CD7-negative lymphoid progenitor OR granulocyte monocyte progenitor", "taxa": []}
{"type": "biolink:Cell", "ic": 60.85137404150132, "identifiers": [{"i": "CL:0000300", "l": "gamete", "d": ["A mature sexual reproductive cell having a single set of unpaired chromosomes."], "t": []}, {"i": "UMLS:C2718310", "l": "Gametes", "d": [], "t": []}, {"i": "SNOMEDCT:308838004", "l": "", "d": [], "t": []}, {"i": "SNOMEDCT:308839007", "l": "", "d": [], "t": []}], "preferred_name": "gamete", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C2950201", "l": "Type D cell of duodenum", "d": [], "t": []}], "preferred_name": "Type D cell of duodenum", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0598117", "l": "stellate cell", "d": [], "t": []}], "preferred_name": "stellate cell", "taxa": []}
{"type": "biolink:Cell", "ic": 84.21065366064373, "identifiers": [{"i": "CL:0000706", "l": "choroid plexus epithelial cell", "d": ["A specialized ependymal cell that is part of the choroid plexus epithelium, responsible for producing cerebrospinal fluid (CSF) by selectively filtering and modifying blood plasma components before secreting it into the brain and spinal cord. This cell is characterized by a brush border on its apical surface, which enhances the secretion of CSF."], "t": []}, {"i": "UMLS:C1182609", "l": "Epithelial cell of choroid plexus", "d": [], "t": []}], "preferred_name": "choroid plexus epithelial cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5571673", "l": "Nucleated cells|NCnc|Pt|Synv fld", "d": [], "t": []}], "preferred_name": "Nucleated cells|NCnc|Pt|Synv fld", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1267995", "l": "Lymphocyte positive for CD115 antigen", "d": [], "t": []}, {"i": "SNOMEDCT:117435001", "l": "", "d": [], "t": []}], "preferred_name": "Lymphocyte positive for CD115 antigen", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "UMLS:C1708892", "l": "Malignant Neuroectodermal Round Cell", "d": [], "t": []}, {"i": "NCIT:C54042", "l": "Malignant Neuroectodermal Round Cell", "d": [], "t": []}], "preferred_name": "Malignant Neuroectodermal Round Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 64.13503802424573, "identifiers": [{"i": "CL:0000079", "l": "stratified epithelial cell", "d": ["An epithelial cell, organized into multiple layers, with only the basal layer being in contact with the basement membrane."], "t": []}], "preferred_name": "stratified epithelial cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5157274", "l": "CD11c+CD25+ cells | Blood | Cell markers", "d": [], "t": []}], "preferred_name": "CD11c+CD25+ cells | Blood | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "UMLS:C1881552", "l": "Malignant Epithelial Small Oval Cell", "d": [], "t": []}, {"i": "NCIT:C60999", "l": "Malignant Epithelial Small Oval Cell", "d": [], "t": []}], "preferred_name": "Malignant Epithelial Small Oval Cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1440420", "l": "Cells.t(X;18)(q11.2;p11.22)(SS18,SSX2)", "d": [], "t": []}], "preferred_name": "Cells.t(X;18)(q11.2;p11.22)(SS18,SSX2)", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C2708700", "l": "Immature cells", "d": [], "t": []}], "preferred_name": "Immature cells", "taxa": []}
{"type": "biolink:Cell", "ic": 92.76600187037766, "identifiers": [{"i": "UMLS:C1517543", "l": "Giant Cell with Myoblastic Differentiation", "d": [], "t": []}, {"i": "NCIT:C36828", "l": "Giant Cell with Myoblastic Differentiation", "d": [], "t": []}], "preferred_name": "Giant Cell with Myoblastic Differentiation", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "CL:4047101", "l": "liver-resident natural killer cell", "d": ["A natural killer cell resident to the liver, located in the hepatic sinusoids. In humans this cell type is distinguished from circulating natural killer cells by CD49a or CD69 gene expression. Liver-resident natural killer cells have also been shown to express CCR5, EOMES, KLRB1, GZMK, and CXCR6 in humans."], "t": []}], "preferred_name": "liver-resident natural killer cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1440295", "l": "CD11b+CD33+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:1373020004", "l": "", "d": [], "t": []}], "preferred_name": "CD11b+CD33+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4300403", "l": "Cells.chromosome region 5q31", "d": [], "t": []}], "preferred_name": "Cells.chromosome region 5q31", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1440331", "l": "CD52+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:1372906001", "l": "", "d": [], "t": []}], "preferred_name": "CD52+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": 82.62268137420203, "identifiers": [{"i": "UMLS:C5856892", "l": "Therapeutic Peripheral Blood Stem Cells", "d": [], "t": []}, {"i": "NCIT:C201557", "l": "Therapeutic Peripheral Blood Stem Cells", "d": ["Any preparation of peripheral blood stem cells (PBSCs)."], "t": []}], "preferred_name": "Therapeutic Peripheral Blood Stem Cells", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0003037", "l": "M7-ON retinal ganglion cell", "d": ["An M7 retinal ganglion cells with synaptic terminals in S4 and is depolarized by illumination of its receptive field center."], "t": []}], "preferred_name": "M7-ON retinal ganglion cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5666980", "l": "Anti-HPV16 TCR-engineered T-cells CRTE7A2-01", "d": [], "t": []}, {"i": "NCIT:C185397", "l": "Anti-HPV16 TCR-engineered T-cells CRTE7A2-01", "d": ["A preparation of T-lymphocytes that has been genetically modified to express a T-cell receptor (TCR) specific for an as of yet not identified viral oncoprotein(s) of human papillomavirus type 16 (HPV16), with potential antineoplastic activity. Upon intravenous administration, the anti-HPV16 TCR-engineered T-cells CRTE7A2-01 specifically recognize and bind to the HPV16 oncoprotein(s) expressed on tumor cells. This may lead to cytotoxic T-lymphocyte (CTL)-mediated elimination of tumor cells expressing the HPV16 oncoprotein(s)."], "t": []}], "preferred_name": "Anti-HPV16 TCR-engineered T-cells CRTE7A2-01", "taxa": []}
{"type": "biolink:Cell", "ic": 90.871710685482, "identifiers": [{"i": "CL:1000505", "l": "kidney pelvis cell", "d": ["A cell that is part of a renal pelvis."], "t": []}], "preferred_name": "kidney pelvis cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5216269", "l": "Monoblasts|NCnc|Pt|Bld", "d": [], "t": []}], "preferred_name": "Monoblasts|NCnc|Pt|Bld", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C4733622", "l": "Plasmodium vivax-infected Red Blood Cell", "d": [], "t": []}, {"i": "NCIT:C155655", "l": "Plasmodium vivax-infected Red Blood Cell", "d": ["A preparation of red blood cells (RBCs) that have been infected with the malaria parasite Plasmodium vivax (P. vivax), with potential immunomodulating and antineoplastic activities. Upon administration of the P. vivax-infected RBCs, the P. vivax infection stimulates host immune responses against the P. vivax-infected RBCs. This also stimulates both innate and adaptive anti-tumor immune responses. This leads to the production of cytokines, including interferon-gamma (IFN-g) and tumor-necrosis factor alpha (TNF-a), the proliferation and activation of natural killer (NK) cells, dendritic cells (DCs), CD4-positive T-lymphocytes, and cytotoxic T-lymphocytes (CTLs). This results in the inhibition of tumor cell proliferation, induction of tumor cell apoptosis, and prevents angiogenesis."], "t": []}], "preferred_name": "Plasmodium vivax-infected Red Blood Cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4733582", "l": "Tab-cel", "d": [], "t": []}], "preferred_name": "Tab-cel", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0682544", "l": "neutrophilic cell", "d": [], "t": []}], "preferred_name": "neutrophilic cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1267882", "l": "Lymphocyte negative for CD16 antigen and positive for CD57 antigen", "d": [], "t": []}, {"i": "SNOMEDCT:117559008", "l": "", "d": [], "t": []}], "preferred_name": "Lymphocyte negative for CD16 antigen and positive for CD57 antigen", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5216193", "l": "Basophils|NCnc|Pt|Plr fld", "d": [], "t": []}], "preferred_name": "Basophils|NCnc|Pt|Plr fld", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:2000063", "l": "ovarian fibroblast", "d": ["Any fibroblast that is part of a female gonad."], "t": []}], "preferred_name": "ovarian fibroblast", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5157650", "l": "CD7 cells | Blood | Cell markers", "d": [], "t": []}], "preferred_name": "CD7 cells | Blood | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1512309", "l": "HL-60/MX2", "d": [], "t": []}, {"i": "NCIT:C20229", "l": "HL-60/MX2", "d": ["HL-60/MX2 is a mitoxantrone resistant derivative of the HL-60 cell line. HL-60/MX2 is approximately 35 fold less sensitive to mitoxantrone than the HL-60 parental cells. HL-60/MX2 cells are cross-resistant to etoposide, teniposide, bisantrene, dactinomycin, 4'-(9-acridinylamino)methane- sulfon-m-anisidide, and the anthracyclines daunorubicin and doxorubicin but retain sensitivity to the Vinca alkaloids vincristine and vinblastine, melphalan, mitomycin C and cisplatin. In addition, the HL-60/MX2 cells display slight collateral sensitivity to bleomycin. Resistance to mitoxantrone is stable for up to six months."], "t": []}], "preferred_name": "HL-60/MX2", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5174628", "l": "Neutrophils.agranular | Blood | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Neutrophils.agranular | Blood | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": 67.65179433958558, "identifiers": [{"i": "CL:0000029", "l": "neural crest derived neuron", "d": ["Any neuron that develops from some migratory neural crest cell."], "t": []}], "preferred_name": "neural crest derived neuron", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5170904", "l": "Leukocyte clumps | Urine sediment | Urinalysis", "d": [], "t": []}], "preferred_name": "Leukocyte clumps | Urine sediment | Urinalysis", "taxa": []}
{"type": "biolink:Cell", "ic": 86.30756602822301, "identifiers": [{"i": "UMLS:C1880539", "l": "Epithelioid Osteoblast", "d": [], "t": []}, {"i": "NCIT:C67121", "l": "Epithelioid Osteoblast", "d": [], "t": []}], "preferred_name": "Epithelioid Osteoblast", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C0376702", "l": "COS Cells", "d": [], "t": []}, {"i": "NCIT:C17968", "l": "COS-1", "d": ["The line was derived from the CV-1 cell line (ATCC CCL-70) by transformation with an origin defective mutant of SV40 which codes for wild type T antigen. The cells contain a single integrated copy of the complete early region of the SV40 genome."], "t": []}, {"i": "MESH:D019556", "l": "COS Cells", "d": [], "t": []}], "preferred_name": "COS Cells", "taxa": []}
{"type": "biolink:Cell", "ic": 88.20185721311867, "identifiers": [{"i": "CL:0000851", "l": "neuromast mantle cell", "d": ["Neuromast mantle cell is a non-sensory cell. Neuromast mantle cells surround the neuromast support cells and neuromast hair cells, separating the neuromast from the epidermis, and secrete cupula in which the ciliary bundles of all the hair cells are embedded."], "t": []}], "preferred_name": "neuromast mantle cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C2717770", "l": "Germ Cells, Plant", "d": [], "t": []}, {"i": "MESH:D055993", "l": "Germ Cells, Plant", "d": [], "t": []}], "preferred_name": "Germ Cells, Plant", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0008033", "l": "decidual pericyte", "d": ["A pericyte of the decidual vasculature."], "t": []}], "preferred_name": "decidual pericyte", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5237032", "l": "Antigen-presenting Cells-expressing HPV16 E6/E7 SQZ-PBMC-HPV", "d": [], "t": []}, {"i": "NCIT:C165256", "l": "Antigen-presenting Cells-expressing HPV16 E6/E7 SQZ-PBMC-HPV", "d": ["A preparation of antigen presenting cells (APCs) specific for human papillomavirus (HPV) type 16 E6 and E7 proteins, with potential immunomodulating and antineoplastic activities. Autologous peripheral blood mononuclear cells (PBMCs) were ex vivo manipulated, using a technique involving membrane disruption to get the HPV16 E6 and E7 proteins into the cells; the resulting APCs present the antigens in a major histocompatibility type I (MHC-I) manner.  Upon administration of the APCs-expressing HPV16 E6/E7 SQZ-PBMC-HPV, these cells activate the immune system to mount a cytotoxic T-lymphocyte (CTL) immune response against tumor cells expressing HPV16 E6 and E7.  HPV16 E6 and E7 play an important role in the development of certain types of cancer."], "t": []}], "preferred_name": "Antigen-presenting Cells-expressing HPV16 E6/E7 SQZ-PBMC-HPV", "taxa": []}
{"type": "biolink:Cell", "ic": 84.83823963392128, "identifiers": [{"i": "UMLS:C1519317", "l": "Signet Ring Lipoblast", "d": [], "t": []}, {"i": "NCIT:C36975", "l": "Signet Ring Lipoblast", "d": [], "t": []}], "preferred_name": "Signet Ring Lipoblast", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "CL:0001027", "l": "CD7-negative lymphoid progenitor cell", "d": ["CD7-negative lymphoid progenitor cell is a lymphoid progenitor cell that is CD34-positive, CD7-negative and CD45RA-negative."], "t": []}], "preferred_name": "CD7-negative lymphoid progenitor cell", "taxa": []}
{"type": "biolink:Cell", "ic": 87.18682603146104, "identifiers": [{"i": "UMLS:C1709174", "l": "Neoplastic Epithelioid Stromal Cell", "d": [], "t": []}, {"i": "NCIT:C54002", "l": "Neoplastic Epithelioid Stromal Cell", "d": [], "t": []}], "preferred_name": "Neoplastic Epithelioid Stromal Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 77.17927671370501, "identifiers": [{"i": "UMLS:C1515879", "l": "Activated Lymphocyte", "d": [], "t": []}, {"i": "NCIT:C32049", "l": "Activated Lymphocyte", "d": ["A white blood cell that, after being in contact with an antigen, rearranges its DNA to defend against that one specific type of antigen. After activation, it can then proliferate and differentiate into memory cells, antibody-secreting cells or plasma cells."], "t": []}], "preferred_name": "Activated Lymphocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1257771", "l": "Burst-Forming Units, Erythroid", "d": [], "t": []}, {"i": "NCIT:C121480", "l": "Erythroid Burst Forming Unit", "d": ["A unit of viable cell concentration defined as the minimum number of hematopoietic stem cells able to produce a detectable colony of erythroid burst forming cells."], "t": []}, {"i": "SNOMEDCT:259732005", "l": "", "d": [], "t": []}], "preferred_name": "Burst-Forming Units, Erythroid", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5173431", "l": "Monocytes | Blood cord | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Monocytes | Blood cord | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": 89.40238429118027, "identifiers": [{"i": "CL:0001071", "l": "group 3 innate lymphoid cell", "d": ["An innate lymphoid cell that constituitively expresses RORgt and is capable of expressing IL17A and/or IL-22."], "t": []}], "preferred_name": "group 3 innate lymphoid cell", "taxa": []}
{"type": "biolink:Cell", "ic": 89.40238429118027, "identifiers": [{"i": "UMLS:C1514933", "l": "Rhabdoid Cell", "d": [], "t": []}, {"i": "NCIT:C37149", "l": "Rhabdoid Cell", "d": [], "t": []}], "preferred_name": "Rhabdoid Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 83.11065783093733, "identifiers": [{"i": "CL:0002222", "l": "vertebrate lens cell", "d": ["A cell comprising the transparent, biconvex body separating the posterior chamber and vitreous body, and constituting part of the refracting mechanism of the mammalian eye."], "t": []}, {"i": "UMLS:C1182776", "l": "Lens cell", "d": [], "t": []}], "preferred_name": "vertebrate lens cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5382904", "l": "HLA-A1 CMV specific CD8 cells | Blood | Cell markers", "d": [], "t": []}], "preferred_name": "HLA-A1 CMV specific CD8 cells | Blood | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5418870", "l": "Anti-CD19/CD22 CAR NK Cells", "d": [], "t": []}, {"i": "NCIT:C170904", "l": "Anti-CD19/CD22 CAR NK Cells", "d": ["A preparation of natural killer (NK) cells engineered to express a chimeric antigen receptor (CAR) specific for the tumor-associated antigens (TAAs) cluster of differentiation 19 (CD19) and CD22, with potential immunostimulating and antineoplastic activities. Upon administration, the anti-CD19/CD22 CAR-NK cells target and bind to CD19 and CD22 expressed on the surface of tumor cells. This induces selective toxicity in tumor cells expressing these TAAs. CD19 and CD22, both transmembrane phosphoglycoproteins expressed on the surface of cells in the B lineage, are often overexpressed on malignant B-cells. By simultaneously targeting two B-cell antigens, this preparation may minimize relapse due to single antigen loss in patients with B-cell malignancies."], "t": []}], "preferred_name": "Anti-CD19/CD22 CAR NK Cells", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C4733635", "l": "Autologous CD30CAR-CD28-CD3zeta-expressing T-Lymphocytes", "d": [], "t": []}, {"i": "NCIT:C155294", "l": "Autologous CD30CAR-CD28-CD3zeta-expressing T-Lymphocytes", "d": ["A preparation of autologous T-lymphocytes (ATL) that have been transduced with the retroviral vector SFG, a Moloney murine leukemia (Mo-MuLV) virus-based vector, encoding a chimeric antigen receptor (CAR) composed of a single chain single-chain variable fragment (scFv) directed against the CD30 antigen (CAR.CD30) and linked, via the spacer human IgG1 immunoglobulin heavy constant region (hinge-CH2CH3 region), to the co-stimulatory domains of CD28 and the zeta chain of the TCR/CD3 complex (CD3-zeta) (CD28zeta), with potential immunostimulating and antineoplastic activities. Upon administration, the autologous CD30CAR-CD28-CD3zeta-expressing T-lymphocytes specifically recognize and bind to CD30-expressing tumor cells, resulting in specific T-cell-mediated tumor cell lysis. CD30, a cell surface receptor and a member of the tumor necrosis factor (TNF) receptor superfamily, is transiently expressed on activated lymphocytes and is constitutively expressed in hematologic malignancies."], "t": []}], "preferred_name": "Autologous CD30CAR-CD28-CD3zeta-expressing T-Lymphocytes", "taxa": []}
{"type": "biolink:Cell", "ic": 59.83141974270748, "identifiers": [{"i": "CL:0000329", "l": "oxygen accumulating cell", "d": ["Any cell that is capable of some oxygen transport."], "t": []}], "preferred_name": "oxygen accumulating cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C2936410", "l": "Spongy Mesophyll Cells", "d": [], "t": []}], "preferred_name": "Spongy Mesophyll Cells", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5983791", "l": "Autologous KRAS G12D Mutant-specific HLA-C*08:02-/KRAS G12D Mutant-specific HLA-A*11:01-/KRAS G12V Mutant-specific HLA-C*01:02-/TP53 R175H Mutant-specific HLA-A*02:01-restricted TCR Genes Engineered T-lymphocytes", "d": [], "t": []}, {"i": "NCIT:C212035", "l": "Autologous KRAS G12D Mutant-specific HLA-C*08:02-/KRAS G12D Mutant-specific HLA-A*11:01-/KRAS G12V Mutant-specific HLA-C*01:02-/TP53 R175H Mutant-specific HLA-A*02:01-restricted TCR Genes Engineered T-lymphocytes", "d": ["A preparation of autologous T-lymphocytes that have been genetically modified to express a T-cell receptor (TCR) specific for the human leukocyte antigen (HLA)-C*08:02-restricted oncogenic K-RAS (KRAS) substitution mutation G12D, a TCR specific for the HLA-A*11:01-restricted KRAS G12D, a TCR specific for the HLA-C*01:02-restricted KRAS G12V, and a TCR specific for the HLA-A*02:01-restricted oncogenic TP53 (p53) substitution mutation R175H, with potential antineoplastic activity. Upon isolation of peripheral blood lymphocytes (PBLs), transduction, expansion ex vivo and re-introduction into the patient, the autologous KRAS G12D mutant-specific HLA-C*08:02-/KRAS G12D mutant-specific HLA-A*11:01-/KRAS G12V mutant-specific HLA-C*01:02-/TP53 R175H mutant-specific HLA-A*02:01-restricted TCR genes engineered T-lymphocytes target and bind to tumor cells expressing the mutants KRAS G12D, KRAS G12V and/or TP53 R175H, resulting in cytotoxic T-lymphocyte (CTL)-mediated killing of KRAS G12D, KRAS G12V and/or TP53 R175H-expressing tumor cells. KRAS, a member of the RAS family of oncogenes, serves an important role in cell signaling, division and differentiation. Mutations of KRAS may induce constitutive signal transduction leading to tumor cell proliferation, invasion, and metastasis. p53, a tumor suppressor gene, is mutated in many tumor cells, resulting in the loss of apoptosis regulation and abnormal cell proliferation."], "t": []}], "preferred_name": "Autologous KRAS G12D Mutant-specific HLA-C*08:02-/KRAS G12D Mutant-specific HLA-A*11:01-/KRAS G12V Mutant-specific HLA-C*01:02-/TP53 R175H Mutant-specific HLA-A*02:01-restricted TCR Genes Engineered T-lymphocytes", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1519265", "l": "Mouse Testis Sertoli Cell", "d": [], "t": []}, {"i": "NCIT:C22183", "l": "Mouse Testis Sertoli Cell", "d": [], "t": []}], "preferred_name": "Mouse Testis Sertoli Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 82.16838616155795, "identifiers": [{"i": "UMLS:C0229630", "l": "Sideroblast", "d": [], "t": []}, {"i": "NCIT:C36718", "l": "Sideroblast", "d": [], "t": []}, {"i": "SNOMEDCT:53838007", "l": "", "d": [], "t": []}], "preferred_name": "Sideroblast", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4733591", "l": "autologous anti-CD20 CAR-T cells", "d": [], "t": []}], "preferred_name": "autologous anti-CD20 CAR-T cells", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4079016", "l": "lumbar dorsal root ganglion Piezo2 neuron", "d": ["A mechanosensitive sensory neuron whose soma is located in the lumbar dorsal root ganglion and that expresses the mechanically activated ion channel Piezo2 (encoded by PIEZO2). This neuron transduces mechanical stimuli and is involved in light touch perception and proprioception. In human DRG, Piezo2-immunoreactive neurons constitute approximately 35% of TrkA-positive neurons, compared to 26% in mouse (Rostock et al. 2018, PMID:29229553). This subpopulation includes both low-threshold mechanoreceptors mediating innocuous touch and a subset of mechanically sensitive nociceptors, reflecting the dual role of Piezo2 in somatosensation across species."], "t": []}], "preferred_name": "lumbar dorsal root ganglion Piezo2 neuron", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4323049", "l": "Oocyte in dictyate arrest", "d": [], "t": []}], "preferred_name": "Oocyte in dictyate arrest", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4322831", "l": "Type 2C muscle fiber", "d": [], "t": []}], "preferred_name": "Type 2C muscle fiber", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C2983758", "l": "NY-ESO-1 Reactive TCR Retroviral Vector Transduced Autologous PBL", "d": [], "t": []}, {"i": "NCIT:C90559", "l": "NY-ESO-1 Reactive TCR Retroviral Vector Transduced Autologous PBL", "d": ["Human autologous peripheral blood lymphocytes (PBLs) transduced with a retroviral vector encoding a T cell receptor (TCR) specific for the cancer-testis antigen NY-ESO-1, with potential antineoplastic activity. Upon isolation, transduction, expansion ex vivo, and reintroduction into the patient, the NY-ESO-1 reactive TCR-transduced autologous PBLs bind to NY-ESO-1-overexpressing tumor cells. This may result in a specific cytotoxic T-lymphocyte (CTL) killing of NY-ESO-1-positive cancer cells. NY-ESO-1, a tumor associated antigen (TAA), is found in normal testis and on the surface of various tumor cell types; the TCR is specific for NY-ESO-1:157-165."], "t": []}], "preferred_name": "NY-ESO-1 Reactive TCR Retroviral Vector Transduced Autologous PBL", "taxa": []}
{"type": "biolink:Cell", "ic": 64.5147471805949, "identifiers": [{"i": "CL:0000557", "l": "granulocyte monocyte progenitor cell", "d": ["A hematopoietic progenitor cell that is committed to the granulocyte and monocyte lineages. These cells are CD123-positive, and do not express Gata1 or Gata2 but do express C/EBPa, and Pu.1."], "t": []}], "preferred_name": "granulocyte monocyte progenitor cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0229521", "l": "Perilymphatic cell", "d": [], "t": []}, {"i": "SNOMEDCT:76535006", "l": "", "d": [], "t": []}], "preferred_name": "Perilymphatic cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4033011", "l": "smooth muscle cell of large intestine smooth muscle circular layer", "d": ["A(n) smooth muscle cell that is part of a(n) large intestine smooth muscle circular layer."], "t": []}], "preferred_name": "smooth muscle cell of large intestine smooth muscle circular layer", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0008020", "l": "skeletal muscle satellite myogenic cell", "d": ["A skeletal muscle satellite cell that undergoes symmetric division to produce two adult skeleltal muscle myoblasts."], "t": []}], "preferred_name": "skeletal muscle satellite myogenic cell", "taxa": []}
{"type": "biolink:Cell", "ic": 74.93438803193563, "identifiers": [{"i": "CL:0000800", "l": "mature gamma-delta T cell", "d": ["A gamma-delta T cell that has a mature phenotype. These cells can be found in tissues and circulation where they express unique TCR repertoire depending on their location."], "t": []}], "preferred_name": "mature gamma-delta T cell", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "CL:0017003", "l": "epithelial cell of prostatic urethra", "d": ["An epithelial cell that is part of the prostatic urethra."], "t": []}], "preferred_name": "epithelial cell of prostatic urethra", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C4086505", "l": "ICT-121 Dendritic Cell Vaccine", "d": [], "t": []}, {"i": "NCIT:C124652", "l": "ICT-121 Dendritic Cell Vaccine", "d": ["A cell-based cancer vaccine composed of autologous dendritic cells (DCs) pulsed with purified peptides derived from the tumor-associated antigen (TAA) CD133, with potential immunostimulatory and antineoplastic activities. Upon leukapheresis, monocytes are differentiated into DCs and are mixed with the CD133 peptides. Upon intradermal re-administration of the ICT-121 DC vaccine, the DCs present the CD133 peptides to the immune system, which stimulates the immune system to induce a specific cytotoxic T-lymphocyte (CTL) response against CD133-expressing tumor cells and leads to tumor cell lysis. CD133 is overexpressed on various types of cancer cells; its overexpression is correlated with increased resistance to chemotherapy."], "t": []}], "preferred_name": "ICT-121 Dendritic Cell Vaccine", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C3176807", "l": "Blasts.cytoplasmic CD3", "d": [], "t": []}], "preferred_name": "Blasts.cytoplasmic CD3", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4310112", "l": "SN GATA3-PAX8 GABA GABAergic interneuron (Primate)", "d": ["A GABAergic interneuron of the Primates brain. These cells are located in the substantia nigra . Reference transcriptomic data for this type can be found in the dataset/taxonomy - HMBA Basal Ganglia Consensus Taxonomy in cell set Group:SN GATA3-PAX8 GABA."], "t": []}], "preferred_name": "SN GATA3-PAX8 GABA GABAergic interneuron (Primate)", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C0003273", "l": "Antibody-Producing Cells", "d": [], "t": []}, {"i": "NCIT:C12611", "l": "Antibody-Producing Cell", "d": ["A type of B lymphocyte that reacts with antigens to produce immune proteins called antibodies."], "t": []}, {"i": "MESH:D000921", "l": "Antibody-Producing Cells", "d": [], "t": []}], "preferred_name": "Antibody-Producing Cells", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4033145", "l": "pterygopalatine ganglion VIP neuron", "d": ["A parasympathetic neuron that has the soma located in the pterygopalatine ganglion and expresses the marker vasoactive intestinal peptide (VIP)."], "t": []}], "preferred_name": "pterygopalatine ganglion VIP neuron", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5783908", "l": "Debamestrocel", "d": [], "t": []}, {"i": "NCIT:C190756", "l": "Debamestrocel", "d": [], "t": []}], "preferred_name": "Debamestrocel", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5382748", "l": "CD107a+b expressing HLA-B35 Cytomegalovirus specific CD8 cells | Blood | Cell markers", "d": [], "t": []}], "preferred_name": "CD107a+b expressing HLA-B35 Cytomegalovirus specific CD8 cells | Blood | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5220558", "l": "Bladder cells|Urine/Urine sed", "d": [], "t": []}], "preferred_name": "Bladder cells|Urine/Urine sed", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C2339724", "l": "Set of cholinergic cells of olfactory tubercle [Ch4]", "d": [], "t": []}], "preferred_name": "Set of cholinergic cells of olfactory tubercle [Ch4]", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4287818", "l": "NiCord", "d": [], "t": []}], "preferred_name": "NiCord", "taxa": []}
{"type": "biolink:Cell", "ic": 90.871710685482, "identifiers": [{"i": "CL:0000091", "l": "Kupffer cell", "d": ["A tissue-resident macrophage of the reticuloendothelial system found on the luminal surface of the hepatic sinusoids involved in erythrocyte clearance. Markers include F4/80+, CD11b-low, CD68-positive, sialoadhesin-positive, CD163/SRCR-positive. Irregular, with long processes including lamellipodia extending into the sinusoid lumen, have flattened nucleus with cytoplasm containing characteristic invaginations of the plasma membrane (vermiform bodies); lie within the sinusoid lumen attached to the endothelial surface; derived from the bone marrow, form a major part of the body's mononuclear phagocyte system."], "t": []}, {"i": "UMLS:C0022801", "l": "Hepatic macrophage", "d": [], "t": []}, {"i": "NCIT:C12564", "l": "Kupffer Cell", "d": ["Large star-shaped or pyramidal cells with a large oval nucleus and a small prominent nucleolus. These intensely phagocytic cells line the walls of the sinusoids of the liver and form a part of the reticuloendothelial system."], "t": []}, {"i": "MESH:D007728", "l": "Kupffer Cells", "d": [], "t": []}, {"i": "SNOMEDCT:256002", "l": "", "d": [], "t": []}], "preferred_name": "Kupffer cell", "taxa": []}
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{"type": "biolink:Cell", "ic": 84.83823963392128, "identifiers": [{"i": "UMLS:C1709194", "l": "Neoplastic Plump Endothelial Cell", "d": [], "t": []}, {"i": "NCIT:C53305", "l": "Neoplastic Plump Endothelial Cell", "d": [], "t": []}], "preferred_name": "Neoplastic Plump Endothelial Cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1268011", "l": "Immature plasma cell", "d": [], "t": []}, {"i": "SNOMEDCT:117293008", "l": "", "d": [], "t": []}], "preferred_name": "Immature plasma cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0000982", "l": "IgG plasmablast", "d": ["A plasmablast that secretes IgG."], "t": []}], "preferred_name": "IgG plasmablast", "taxa": []}
{"type": "biolink:Cell", "ic": 88.20185721311867, "identifiers": [{"i": "CL:1001589", "l": "duodenum secretory cell", "d": ["Glandular cell of duodenal epithelium. Example: Enterocytes, Goblet cells, enteroendocrine cells; Paneth cells; M cells; Brunner's gland cell."], "t": []}], "preferred_name": "duodenum secretory cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4052039", "l": "tuft cell of submandibular gland", "d": ["A tuft cell that is part of the epithelium of the submandibular gland, localized to the striated ducts in mice, pigs, and humans, and to the main excretory ducts in rats. This cell is characterized by chemosensory functions, potential roles in immune regulation, and possible involvement in salivary secretion via acetylcholine release."], "t": []}], "preferred_name": "tuft cell of submandibular gland", "taxa": []}
{"type": "biolink:Cell", "ic": 90.871710685482, "identifiers": [{"i": "CL:0000773", "l": "eosinophilic metamyelocyte", "d": ["A eosinophil precursor in the granulocytic series, being a cell intermediate in development between a eosinophilic myelocyte and a band form eosinophil. The nucleus becomes indented where the indentation is smaller than half the distance to the farthest nuclear margin; chromatin becomes coarse and clumped; specific granules predominate while primary granules are rare. Markers are integrin alpha-M-positive, fucosyltransferase FUT4-positive, low affinity immunoglobulin gamma Fc region receptor III-positive, CD33-positive, CD24-positive and aminopeptidase N-negative."], "t": []}], "preferred_name": "eosinophilic metamyelocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1522131", "l": "Mouse T-Lymphocyte", "d": [], "t": []}, {"i": "NCIT:C22582", "l": "Mouse T-Lymphocyte", "d": [], "t": []}], "preferred_name": "Mouse T-Lymphocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 79.9528279018387, "identifiers": [{"i": "CL:0000010", "l": "cultured cell", "d": ["A cell in vitro that is or has been maintained or propagated as part of a cell culture."], "t": []}, {"i": "UMLS:C0007635", "l": "Cultured Cells", "d": [], "t": []}, {"i": "NCIT:C45382", "l": "Cell Strain", "d": ["Cells adapted to culture, but with finite division potential."], "t": []}, {"i": "MESH:D002478", "l": "Cells, Cultured", "d": [], "t": []}, {"i": "SNOMEDCT:702451000", "l": "", "d": [], "t": []}], "preferred_name": "cultured cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5833426", "l": "Human umbilical tissue-derived cells", "d": [], "t": []}], "preferred_name": "Human umbilical tissue-derived cells", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "CL:0002378", "l": "immature Vgamma2-positive fetal thymocyte", "d": ["A double negative thymocyte that has a T cell receptor consisting of a gamma chain containing a Vgamma2 segment, and a delta chain. This cell type is CD4-negative, CD8-negative and CD24-positive and is found in the fetal thymus."], "t": []}], "preferred_name": "immature Vgamma2-positive fetal thymocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:1000327", "l": "appendix goblet cell", "d": ["A goblet cell that is part of the epithelium proper of appendix."], "t": []}, {"i": "UMLS:C2336894", "l": "Goblet cell of epithelium proper of appendix", "d": [], "t": []}], "preferred_name": "appendix goblet cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4310122", "l": "striatal SST-ADARB2 GABAergic interneuron (Primate)", "d": ["A sst GABAergic interneuron of the Primates brain. These cells are located in the striatum . Reference transcriptomic data for this type can be found in the dataset/taxonomy - HMBA Basal Ganglia Consensus Taxonomy in cell set Group:STR SST-ADARB2 GABA."], "t": []}], "preferred_name": "striatal SST-ADARB2 GABAergic interneuron (Primate)", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0011017", "l": "vagal neural crest cell", "d": ["Cell that is part of the vagal neural crest population. The vagal neural crest arises from the axial level of somites 1-7 and has been described as a hybrid between the head and the trunk populations."], "t": []}], "preferred_name": "vagal neural crest cell", "taxa": []}
{"type": "biolink:Cell", "ic": 88.20185721311867, "identifiers": [{"i": "CL:0000962", "l": "Bm2 B cell", "d": ["A follicular B cell that is IgD-positive and CD23-positive and CD38-positive. This naive cell type is activated in the extrafollicular areas via interaction with dendritic cells and antigen specific T cells."], "t": []}], "preferred_name": "Bm2 B cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C6064629", "l": "CyIg mu+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:1376051001", "l": "", "d": [], "t": []}], "preferred_name": "CyIg mu+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5151349", "l": "Abnormal lymphocytes | Body fluid | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Abnormal lymphocytes | Body fluid | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:1000606", "l": "kidney nerve cell", "d": ["Any neuron that has its soma located in some kidney."], "t": []}], "preferred_name": "kidney nerve cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5178092", "l": "Prekeratocytes | Blood | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Prekeratocytes | Blood | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": 76.22330125402472, "identifiers": [{"i": "UMLS:C1518242", "l": "Malignant Small Hyperchromatic Cell", "d": [], "t": []}, {"i": "NCIT:C36861", "l": "Malignant Small Hyperchromatic Cell", "d": [], "t": []}], "preferred_name": "Malignant Small Hyperchromatic Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:1000385", "l": "type 2 vestibular sensory cell of epithelium of crista of ampulla of semicircular duct of membranous labyrinth", "d": ["A type II vestibular sensory cell that is part of the epithelium of crista of ampulla of semicircular duct of membranous labyrinth."], "t": []}, {"i": "UMLS:C2335952", "l": "Type 2 vestibular sensory cell of epithelium of crista of ampulla of semicircular duct of membranous labyrinth", "d": [], "t": []}], "preferred_name": "type 2 vestibular sensory cell of epithelium of crista of ampulla of semicircular duct of membranous labyrinth", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C3496153", "l": "A9 cell group", "d": [], "t": []}], "preferred_name": "A9 cell group", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4033018", "l": "lung megakaryocyte", "d": ["A megakaryocyte that is resident in the lung connective tissue."], "t": []}], "preferred_name": "lung megakaryocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0009023", "l": "small intestine Peyer's patch T cell", "d": ["A T cell which resides in the Peyer's patch of the small intestine."], "t": []}], "preferred_name": "small intestine Peyer's patch T cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4038497", "l": "Cells.aneuploid.G2 phase population", "d": [], "t": []}], "preferred_name": "Cells.aneuploid.G2 phase population", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C2362797", "l": "Blood cell precursor - general anatomical term", "d": [], "t": []}], "preferred_name": "Blood cell precursor - general anatomical term", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "CL:4023181", "l": "hypendymal cell", "d": ["A neurecto-epithelial cell that is part of the basal layer of the subcommissural organ and specializes in the secretion of proteins into the subarachnoid space. Hypendymal cells have similar characteristics to ependymal cells and express SCO-spondin."], "t": []}], "preferred_name": "hypendymal cell", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "CL:0009089", "l": "lung pericyte", "d": ["A pericyte cell that is part of a lung."], "t": []}], "preferred_name": "lung pericyte", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C2924223", "l": "CD13+CD34+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:1372968002", "l": "", "d": [], "t": []}], "preferred_name": "CD13+CD34+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4033085", "l": "diffuse bipolar 5 cell", "d": ["An ON diffuse bipolar cell that stratifies in the stratum 3 of the inner plexiform layer to make synapses with ON parasol ganglion cells. A diffuse bipolar 5 cell has high expression of MYO16 compared with other bipolar cells."], "t": []}], "preferred_name": "diffuse bipolar 5 cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1956319", "l": "Common Myeloid Progenitors", "d": [], "t": []}], "preferred_name": "Common Myeloid Progenitors", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:1000289", "l": "myocyte of atrial septal branch of anterior internodal tract", "d": ["A muscle cell that is part of the atrial septal branch of anterior internodal tract."], "t": []}, {"i": "UMLS:C2335794", "l": "Myocyte of atrial septal branch of anterior internodal tract", "d": [], "t": []}], "preferred_name": "myocyte of atrial septal branch of anterior internodal tract", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0000883", "l": "thymic cortical macrophage", "d": ["A thymic macrophage found in the thymic cortex."], "t": []}], "preferred_name": "thymic cortical macrophage", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C3178760", "l": "Mirror Neurons", "d": [], "t": []}, {"i": "MESH:D059167", "l": "Mirror Neurons", "d": [], "t": []}], "preferred_name": "Mirror Neurons", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5159882", "l": "Circulating tumor cells.prostate | Blood | Chemistry - non-challenge", "d": [], "t": []}], "preferred_name": "Circulating tumor cells.prostate | Blood | Chemistry - non-challenge", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C3653065", "l": "stem cells from umbilical cord blood", "d": [], "t": []}], "preferred_name": "stem cells from umbilical cord blood", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5157297", "l": "CD13 blasts | XXX | Cell markers", "d": [], "t": []}], "preferred_name": "CD13 blasts | XXX | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1648298", "l": "CD7+CD8+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:1373047009", "l": "", "d": [], "t": []}], "preferred_name": "CD7+CD8+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4708585", "l": "Technetium (99m-Tc) labeled granulocytes", "d": [], "t": []}, {"i": "SNOMEDCT:768885006", "l": "", "d": [], "t": []}], "preferred_name": "Technetium (99m-Tc) labeled granulocytes", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C3898190", "l": "NY-ESO-1-specific CD4-positive T Lymphocytes", "d": [], "t": []}, {"i": "NCIT:C117724", "l": "NY-ESO-1-specific CD4-positive T Lymphocytes", "d": ["A preparation of autologous CD4+ T-lymphocytes sensitized to cancer-testis antigen NY-ESO-1, with potential immunostimulating and antineoplastic activities. CD4-positive T-lymphocytes are exposed to a NY-ESO-1 peptide ex vivo, expanded, and introduced into the patient. The NY-ESO-1-specific CD4-positive T-lymphocytes may stimulate the host immune system to produce a cytotoxic T-lymphocyte (CTL) response against tumor cells expressing the NY-ESO-1 antigen, which results in tumor cell lysis. NY-ESO-1, an antigen found in normal testis, may be upregulated in various cancers."], "t": []}], "preferred_name": "NY-ESO-1-specific CD4-positive T Lymphocytes", "taxa": []}
{"type": "biolink:Cell", "ic": 90.871710685482, "identifiers": [{"i": "CL:0002525", "l": "metanephric podocyte", "d": ["A specialized epithelial cell that contains \"feet\" that interdigitate with the \"feet\" of other glomerular epithelial cells in the metanephros."], "t": []}], "preferred_name": "metanephric podocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 80.27409497666227, "identifiers": [{"i": "CL:0011001", "l": "spinal cord motor neuron", "d": ["A motor neuron that passes from the spinal cord toward or to a muscle and conducts an impulse that causes movement."], "t": []}], "preferred_name": "spinal cord motor neuron", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5417841", "l": "Autologous CD19-targeted CAR-T Cells GC007F", "d": [], "t": []}, {"i": "NCIT:C171092", "l": "Autologous CD19-targeted CAR-T Cells GC007F", "d": ["A preparation of autologous T-lymphocytes that have been genetically modified to express a chimeric antigen receptor (CAR) consisting of a single chain variable fragment (scFv) of anti-CD19 coupled to as of yet not fully elucidated co-stimulatory molecules, with potential immunostimulating and antineoplastic activities. Upon transfusion, autologous CD19-targeted CAR-T cells GC007F target and bind to CD19-expressing neoplastic B-cells. This results in a cytotoxic T-lymphocyte (CTL) response against CD19-expressing tumor cells, the release of cytotoxic molecules and the induction of tumor cell lysis. CD19, cluster of differentiation 19, is a B-cell-specific cell surface antigen overexpressed in B-cell lineage tumors. The processing platform used, FasT (F) CAR-T, shortens the manufacturing time to produce the CAR-T cells within 24 hours."], "t": []}], "preferred_name": "Autologous CD19-targeted CAR-T Cells GC007F", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "CL:0000704", "l": "endothelial tip cell", "d": ["A specialized endothelial cell that senses extracellular signals and guides the directed growth of blood vessels."], "t": []}], "preferred_name": "endothelial tip cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0002581", "l": "perirenal preadipocyte", "d": ["A preadipocyte that is part of a perirenal fat tissue."], "t": []}], "preferred_name": "perirenal preadipocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 90.871710685482, "identifiers": [{"i": "CL:0000965", "l": "Bm3 B cell", "d": ["A germinal center B cell that is rapidly dividing and has the phenotype IgD-negative, CD38-positive, and CD77-positive. Somatic hypermutation of the immunoglobulin V gene region can occur during proliferation of this cell type."], "t": []}], "preferred_name": "Bm3 B cell", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "CL:0002137", "l": "type III cell of adrenal cortex", "d": ["A cell in the zona reticularis that produce sex hormones."], "t": []}, {"i": "UMLS:C1181740", "l": "Type III cell of adrenal cortex", "d": [], "t": []}], "preferred_name": "type III cell of adrenal cortex", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1517358", "l": "GE91", "d": [], "t": []}, {"i": "NCIT:C20261", "l": "GE91", "d": ["Provider: Geron Corporation, Menlo Park, CA. No information from provider. This cell line meets the criteria for the use of human embryonic stem cells by federally funded researchers."], "t": []}], "preferred_name": "GE91", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1440236", "l": "CD104+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:725329009", "l": "", "d": [], "t": []}], "preferred_name": "CD104+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": 84.21065366064373, "identifiers": [{"i": "UMLS:C1709205", "l": "Neoplastic Spindle Stromal Cell", "d": [], "t": []}, {"i": "NCIT:C54001", "l": "Neoplastic Spindle Stromal Cell", "d": [], "t": []}], "preferred_name": "Neoplastic Spindle Stromal Cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5157626", "l": "CD59 Granulocytes | Blood | Cell markers", "d": [], "t": []}], "preferred_name": "CD59 Granulocytes | Blood | Cell markers", "taxa": []}
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{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5784926", "l": "Autologous Orthogonal IL-2Rbeta-expressing Anti-CD19 CAR T-cells SYNCAR-001", "d": [], "t": []}, {"i": "NCIT:C192137", "l": "Autologous Orthogonal IL-2Rbeta-expressing Anti-CD19 CAR T-cells SYNCAR-001", "d": ["A preparation of autologous T-lymphocytes that have been genetically modified and transduced with a lentiviral vector expressing a chimeric antigen receptor (CAR) targeting the tumor-associated antigen (TAA) CD19 fused to the extracellular, transmembrane and intracellular signaling domains of the T-cell co-stimulatory receptor CD28 and the cytoplasmic signaling domain of the zeta chain of the TCR/CD3 complex (CD3-zeta) and expressing a mutated orthogonal (ortho) interleukin (IL)-2beta receptor (hoRbeta; hoRb), with potential immunostimulating and antineoplastic activities. Upon administration, autologous hoRb-expressing anti-CD19 CAR T-cells SYNCAR-001 target and bind to CD19-expressing tumor cells, thereby inducing selective toxicity in CD19-expressing tumor cells. CD19 antigen is a B-cell specific cell surface antigen expressed in all B-cell lineage malignancies. Stimulation of hoRb specifically by orthogonal (ortho) IL-2 STK-009 allows for IL-2 signaling specifically in SYNCAR-001 and leads to increased proliferation, persistence and anti-tumor activity of SYNCAR-001. This may lead to dose reduction of SYNCAR-001. hoRb does not respond to the native IL-2 ligand. As STK-009 does not cause IL-2-mediated signaling in other immune cells, systemic toxicity is limited."], "t": []}], "preferred_name": "Autologous Orthogonal IL-2Rbeta-expressing Anti-CD19 CAR T-cells SYNCAR-001", "taxa": []}
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{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4079005", "l": "cervical dorsal root ganglion Piezo2 neuron", "d": ["A mechanosensitive sensory neuron whose soma is located in the cervical dorsal root ganglion and that expresses the mechanically activated ion channel Piezo2 (encoded by PIEZO2). This neuron transduces mechanical stimuli and is involved in light touch perception and proprioception. In human DRG, Piezo2-immunoreactive neurons constitute approximately 35% of TrkA-positive neurons, compared to 26% in mouse (Rostock et al. 2018, PMID:29229553). This subpopulation includes both low-threshold mechanoreceptors mediating innocuous touch and a subset of mechanically sensitive nociceptors, reflecting the dual role of Piezo2 in somatosensation across species."], "t": []}], "preferred_name": "cervical dorsal root ganglion Piezo2 neuron", "taxa": []}
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{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C3900029", "l": "Anti-CD22-CAR m971-BBz Lentiviral Vector-transduced Autologous T Lymphocytes", "d": [], "t": []}, {"i": "NCIT:C120035", "l": "Anti-CD22-CAR m971-BBz Lentiviral Vector-transduced Autologous T Lymphocytes", "d": ["Autologous human T-lymphocytes transduced with a recombinant lentiviral vector encoding a chimeric T-cell receptor (chimeric antigen receptor or CAR) consisting of an anti-CD22 single chain variable fragment (scFv) derived from the monoclonal antibody (moAb) 971 (m971), and the co-stimulatory domain 4-1BB (CD137) coupled to the zeta chain of the TCR/CD3 complex (CD3-zeta), with potential immunostimulating and antineoplastic activities. Autologous peripheral blood lymphocytes (PBLs) from a patient with CD22-positive cancer are transduced with this lentiviral vector that encodes the CAR gene specific for CD22. After expansion in culture and reintroduction into the patient, the anti-CD22-CAR m971-BBz lentiviral vector-transduced autologous T-lymphocytes express anti-CD22-CAR on their cell surfaces and bind to the CD22 antigen on tumor cell surfaces. Subsequently, CD22-expressing tumor cells are lysed. CD22, a B-lineage-restricted, transmembrane phosphoglycoprotein, is expressed on malignant B-cells. m971 binds to a membrane proximal epitope on CD22 and has a higher binding affinity compared to other anti-CD22 moAb."], "t": []}], "preferred_name": "Anti-CD22-CAR m971-BBz Lentiviral Vector-transduced Autologous T Lymphocytes", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C3827147", "l": "Adenovector-transduced AP1903-inducible MyD88/CD40-expressing Autologous PSMA-specific Prostate Cancer Vaccine BPX-201", "d": [], "t": []}, {"i": "NCIT:C106242", "l": "Adenovector-transduced AP1903-inducible MyD88/CD40-expressing Autologous PSMA-specific Prostate Cancer Vaccine BPX-201", "d": ["A genetically-modified, dendritic cell-based (DCs) vaccine in which the autologous cells are transduced with an adenoviral vector expressing the tumor antigen prostate-specific membrane antigen (PSMA) and a fusion protein composed of synthetic ligand inducible adjuvant iMC composed of a drug-inducible costimulatory CD40 receptor (iCD40) and the adaptor protein MyD88, with potential immunomodulating and antineoplastic activities. The iCD40 contains a membrane-localized cytoplasmic CD40 domain fused to the FK506 modified drug-binding protein 12 (FKBP12). Upon intradermal administration of BPX-201, these DCs accumulate in local draining lymph nodes. Twenty-four hours after vaccination, the dimerizing agent AP1903 is administered. AP1903 binds to the drug binding domain, leading to iMC oligomerization and activation of iCD40 and MyD88-mediated signaling in iMC-expressing DCs. This signaling pathway activates the DCs and stimulates a cytotoxic T-lymphocyte (CTL) response against host tumor cells that express PSMA. PSMA, a glycoprotein secreted by prostatic epithelial and ductal cells, is overexpressed in prostate cancer cells and is used as a tumor marker for both diagnosis and treatment evaluation. MyD88 is involved in interleukin 1 receptor (IL1R) and toll-like receptor (TLR) signaling."], "t": []}], "preferred_name": "Adenovector-transduced AP1903-inducible MyD88/CD40-expressing Autologous PSMA-specific Prostate Cancer Vaccine BPX-201", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5221135", "l": "Plasma cells.monotypic.S phase", "d": [], "t": []}], "preferred_name": "Plasma cells.monotypic.S phase", "taxa": []}
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{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1517815", "l": "Mouse Follicular Center Cell", "d": [], "t": []}, {"i": "NCIT:C22578", "l": "Mouse Follicular Center Cell", "d": [], "t": []}], "preferred_name": "Mouse Follicular Center Cell", "taxa": []}
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{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:2000042", "l": "embryonic fibroblast", "d": ["Any fibroblast that is part of a embryo."], "t": []}], "preferred_name": "embryonic fibroblast", "taxa": []}
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{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5555028", "l": "Allogeneic CD19CAR-CD28-CD3-zeta-expressing T-lymphocytes", "d": [], "t": []}, {"i": "NCIT:C178433", "l": "Allogeneic CD19CAR-CD28-CD3-zeta-expressing T-lymphocytes", "d": ["A preparation of allogeneic, donor-derived T-lymphocytes that have been genetically modified to express a chimeric antigen receptor (CAR) consisting of an anti-CD19 scFv (single chain variable fragment), fused to the extracellular, transmembrane and intracellular signaling domains of the T-cell co-stimulatory receptor CD28 and the cytoplasmic signaling domain of the zeta chain of the TCR/CD3 complex (CD3-zeta) (19-28z), with potential immunostimulating and antineoplastic activities. Upon administration, allogeneic CD19CAR-CD28-CD3-zeta-expressing T-lymphocytes are directed to CD19-expressing tumor cells, which induces selective toxicity in CD19-expressing tumor cells. CD19 antigen is a B-cell specific cell surface antigen expressed in all B-cell lineage malignancies. The CD28 co-stimulatory molecule signaling domain enhances activation and signaling after recognition of CD19. The inclusion of the CD28 signaling domain may increase proliferation of T-cells and antitumor activity compared to the inclusion of the CD3-zeta chain alone."], "t": []}], "preferred_name": "Allogeneic CD19CAR-CD28-CD3-zeta-expressing T-lymphocytes", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5691289", "l": "Tonsillar M Cells", "d": [], "t": []}], "preferred_name": "Tonsillar M Cells", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5417765", "l": "Q-Cells", "d": [], "t": []}], "preferred_name": "Q-Cells", "taxa": []}
{"type": "biolink:Cell", "ic": 90.871710685482, "identifiers": [{"i": "CL:1000217", "l": "growth plate cartilage chondrocyte", "d": ["Any chondrocyte that is part of some growth plate cartilage."], "t": []}], "preferred_name": "growth plate cartilage chondrocyte", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5172364", "l": "Megaloblasts | Blood | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Megaloblasts | Blood | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C2987399", "l": "Anti-CD3 x Anti-CD20 Bispecific Antibody-Armed Activated T Cells", "d": [], "t": []}, {"i": "NCIT:C95751", "l": "Anti-CD3 x Anti-CD20 Bispecific Antibody-Armed Activated T Cells", "d": ["Autologous activated T cells that have been coated with bispecific antibodies (BiAb), with potential antineoplastic and immunomodulating activities. In vitro, T cells are activated through exposure to the anti-CD3 murine monoclonal antibody OKT3 and low-dose interleukin 2 (Il-2) for 6-14 days and then armed with anti-CD3 x anti-CD20 bispecific antibody (CD20Bi). Upon administration, anti-CD3 x anti-CD20 bispecific antibody-armed activated T cells (AATC) attach to CD3-expressing T cells and CD20-expressing tumor cells, selectively cross-linking T cells and tumor cells. This may result in the recruitment and activation of cytotoxic T lymphocyte (CTLs), CTL-mediated specific tumor cell lysis, and the secretion of antitumor cytokines and chemokines. CD20, a cell surface phosphoprotein, is found on normal B cells and most B-cell tumors."], "t": []}], "preferred_name": "Anti-CD3 x Anti-CD20 Bispecific Antibody-Armed Activated T Cells", "taxa": []}
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{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C6049666", "l": "Therapeutic Ex Vivo-expanded Allogeneic gamma delta T-cells TCB-202", "d": [], "t": []}], "preferred_name": "Therapeutic Ex Vivo-expanded Allogeneic gamma delta T-cells TCB-202", "taxa": []}
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{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5161796", "l": "Cytoplasmic CD179a blasts | Bone marrow | Cell markers", "d": [], "t": []}], "preferred_name": "Cytoplasmic CD179a blasts | Bone marrow | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4072765", "l": "Cells.ALK gene rearrangements", "d": [], "t": []}], "preferred_name": "Cells.ALK gene rearrangements", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1267795", "l": "Mononuclear cell (histiocyte, lymphocyte, plasma cell)", "d": [], "t": []}, {"i": "SNOMEDCT:116711000", "l": "", "d": [], "t": []}], "preferred_name": "Mononuclear cell (histiocyte, lymphocyte, plasma cell)", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0684123", "l": "Late erythroblast", "d": [], "t": []}], "preferred_name": "Late erythroblast", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5154476", "l": "Basophils | Body fluid | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Basophils | Body fluid | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0486825", "l": "Germ cells.immature", "d": [], "t": []}], "preferred_name": "Germ cells.immature", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0682552", "l": "Parenchymal cell", "d": [], "t": []}], "preferred_name": "Parenchymal cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C4727561", "l": "Autologous NY-ESO-1-redirected CRISPR-edited T Cells", "d": [], "t": []}, {"i": "NCIT:C154288", "l": "Autologous NY-ESO-1-redirected CRISPR-edited T Cells", "d": ["A preparation of human autologous T-lymphocytes that are transduced with a lentiviral vector (LV) encoding a T-cell receptor (TCR) specific for the tumor-associated antigen (TAA) cancer-testis antigen NY-ESO-1 and gene-edited with the clustered regularly interspaced short palindromic repeats (CRISPR)-Cas9 nuclease complex to eliminate endogenous TCR and programmed cell death 1 (PD-1) expression, with potential immunostimulating and antineoplastic activities. The CRISPR guide RNA (gRNA) specifically targets and binds to complementary sites on TCRalpha, TCRbeta and PD-1. In turn, Cas9 cleaves these specific DNA sites, thereby disrupting transcription. Upon isolation, transduction, electroporation with TCRalpha, TCRbeta and PD-1 gRNAs which are complexed to Cas9 RNA to disrupt expression of endogenous TCRalpha, TCRbeta and PD-1, expansion ex vivo, and reintroduction into the patient, the anti-NY-ESO-1 TCR LV-transduced CRISPR-edited autologous T-cells recognize and bind to NY-ESO-1-overexpressing tumor cells. This may result in a specific cytotoxic T-lymphocyte (CTL)-mediated killing of NY-ESO-1-positive tumor cells. NY-ESO-1, a tumor-associated antigen (TAA), is found in normal testis and on the surface of various tumor cell types, and is not, or is minimally, expressed in normal, healthy cells. PD-1, an immune checkpoint receptor expressed on T-cells, plays a key role in tumor immune evasion by binding to its ligand programmed cell death ligand 1 (PD-L1) expressed on tumor cells. By removing PD-1 from T-cells, PD-1-mediated signaling is halted which may decrease T-cell exhaustion and may enhance T-cell activity against the NY-ESO-1-expressing tumor cells. Removal of endogenous TCR reduces TCR competition for expression, increases the persistence and function of the expressed transgenic TCR, enhances resistance to T-cell exhaustion and increases T-cell activity."], "t": []}], "preferred_name": "Autologous NY-ESO-1-redirected CRISPR-edited T Cells", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5571776", "l": "CD19+FMC7+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:1373098003", "l": "", "d": [], "t": []}], "preferred_name": "CD19+FMC7+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": 79.9528279018387, "identifiers": [{"i": "CL:0000605", "l": "fungal asexual spore", "d": ["A spore formed following mitosis or mitoses."], "t": []}], "preferred_name": "fungal asexual spore", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0882932", "l": "CD8+CD28+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:1373050007", "l": "", "d": [], "t": []}], "preferred_name": "CD8+CD28+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4740198", "l": "BAFF-R Cells", "d": [], "t": []}], "preferred_name": "BAFF-R Cells", "taxa": []}
{"type": "biolink:Cell", "ic": 79.07356789860069, "identifiers": [{"i": "CL:1000454", "l": "kidney collecting duct epithelial cell", "d": ["An epithelial cell that is part of the collecting duct of renal tubule."], "t": []}, {"i": "UMLS:C1182799", "l": "Epithelial cell of collecting duct of renal tubule", "d": [], "t": []}], "preferred_name": "kidney collecting duct epithelial cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5939464", "l": "Epithelial cells.squamous|PrThr|Urine", "d": [], "t": []}], "preferred_name": "Epithelial cells.squamous|PrThr|Urine", "taxa": []}
{"type": "biolink:Cell", "ic": 75.08236434612573, "identifiers": [{"i": "UMLS:C1510727", "l": "Abnormal Intermediate Type Trophoblastic Cell", "d": [], "t": []}, {"i": "NCIT:C36802", "l": "Abnormal Intermediate Type Trophoblastic Cell", "d": [], "t": []}], "preferred_name": "Abnormal Intermediate Type Trophoblastic Cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4322820", "l": "CD103+ T lymphocyte", "d": [], "t": []}], "preferred_name": "CD103+ T lymphocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C4329370", "l": "Autologous ICASP9-CD19-expressing T-Lymphocytes", "d": [], "t": []}, {"i": "NCIT:C131214", "l": "Autologous iCasp9-deltaNGFR-CD19CAR-expressing T Cells", "d": ["A preparation of autologous T-lymphocytes that are transduced with a retroviral vector encoding a chimeric antigen receptor (CAR) specific for the CD19 antigen, the suicide gene, inducible human caspase 9 (iCasp9 or iC9), and a truncated low-affinity nerve growth factor receptor (deltaNGFR), with potential immunomodulating and antineoplastic activities. The iCasp9 construct consists of the entire coding sequence for the human FK506-drug binding protein (FKBP12) with an F36V mutation (FKBP12-F36V) that is linked to the gene encoding human caspase 9, which is deleted of its endogenous caspase activation and recruitment domains. Upon intravenous administration, autologous iCasp9-deltaNGFR-CD19CAR-expressing T cells are selectively toxic to CD19-expressing tumor cells. If the administered T-cells lead to unacceptable side effects, the chemical homodimerizer AP1903 can be administered, which binds to the FKBP12-F36V drug binding domain, activates caspase 9, and results in apoptosis of the administered CAR19 T-cells. The CD19 antigen is a B-cell specific cell surface antigen expressed in all B-cell lineage malignancies. Prior to administration, deltaNGFR, is used to select the CAR19-transduced T-cells for further enrichment by flow cytometry using an anti-NGFR antibody."], "t": []}], "preferred_name": "Autologous ICASP9-CD19-expressing T-Lymphocytes", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C6063263", "l": "Cell positive for MPO antigen", "d": [], "t": []}, {"i": "SNOMEDCT:1373078008", "l": "", "d": [], "t": []}], "preferred_name": "Cell positive for MPO antigen", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0483191", "l": "cd4 and cd8+", "d": [], "t": []}], "preferred_name": "cd4 and cd8+", "taxa": []}
{"type": "biolink:Cell", "ic": 85.53200374075534, "identifiers": [{"i": "UMLS:C1513937", "l": "Neoplastic Chondroblast", "d": [], "t": []}, {"i": "NCIT:C36985", "l": "Neoplastic Chondroblast", "d": [], "t": []}], "preferred_name": "Neoplastic Chondroblast", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5382747", "l": "CD107a+b expressing HLA-A2 Cytomegalovirus specific CD8 cells | Blood | Cell markers", "d": [], "t": []}], "preferred_name": "CD107a+b expressing HLA-A2 Cytomegalovirus specific CD8 cells | Blood | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0229426", "l": "Secondary sclerotic mastoid cell", "d": [], "t": []}, {"i": "SNOMEDCT:57106004", "l": "", "d": [], "t": []}], "preferred_name": "Secondary sclerotic mastoid cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5220599", "l": "Leukocytes|Urine/Urine sed", "d": [], "t": []}], "preferred_name": "Leukocytes|Urine/Urine sed", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5706236", "l": "Autologous Muscle-derived Cells for Gastrointestinal Repair", "d": [], "t": []}, {"i": "NCIT:C188383", "l": "Autologous Muscle-derived Cells for Gastrointestinal Repair", "d": ["A preparation of autologous human muscle-derived stem cells (MDSCs), that can potentially be used for engraftment purposes for gastrointestinal (GI) repair (GIR). Upon administration, autologous muscle-derived cells (AMDC) for GI repair (AMDC-GIR) differentiate and self-renew. This allows for certain damaged GI tissues to be repaired."], "t": []}], "preferred_name": "Autologous Muscle-derived Cells for Gastrointestinal Repair", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5163554", "l": "Epithelial cells.squamous | Body fluid | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Epithelial cells.squamous | Body fluid | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5959688", "l": "Allogeneic Anti-CD123 CAR-NK Cells JD123", "d": [], "t": []}, {"i": "NCIT:C206269", "l": "Allogeneic Anti-CD123 CAR-NK Cells JD123", "d": ["A preparation of off-the-shelf (OTS), allogeneic natural killer (NK) cells engineered to express a chimeric antigen receptor (CAR) specific for the tumor-associated antigen (TAA) human interleukin-3 receptor alpha chain (IL3RA; cluster of differentiation 123; CD123), with potential immunomodulating and antineoplastic activities. Upon administration, allogeneic anti-CD123 CAR-NK cells JD123 recognize, bind to and induce selective cytotoxicity in CD123-expressing tumor cells. CD123 is normally expressed on committed blood progenitor cells in the bone marrow; its overexpression is associated with both increased leukemic cell proliferation and aggressiveness."], "t": []}], "preferred_name": "Allogeneic Anti-CD123 CAR-NK Cells JD123", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5856108", "l": "Autologous Anti-BCMA/CS1 Bispecific CAR-T Cells", "d": [], "t": []}, {"i": "NCIT:C200113", "l": "Autologous Anti-BCMA/CS1 Bispecific CAR-T Cells", "d": ["A preparation of autologous T-lymphocytes engineered to express a chimeric antigen receptor (CAR) targeting both the tumor-associated antigens (TAAs) B-cell maturation antigen (BCMA; TNFRSF17) and human CS1 (CD2 subset 1; SLAM family member 7; SLAMF7; CD319; CRACC), with potential immunomodulating and antineoplastic activities. Upon administration, the autologous anti-BCMA/CS1 bispecific CAR-T cells target and bind to tumor cells expressing BCMA and/or CS1 and induce selective cytotoxicity in those cells. BCMA, a receptor for both a proliferation-inducing ligand (APRIL) and B-cell activating factor (BAFF), is a member of the tumor necrosis factor receptor superfamily (TNFRSF). BCMA is found on the surfaces of plasma cells, is overexpressed on malignant plasma cells and plays a key role in plasma cell proliferation and survival. SLAMF7 is a member of the signaling lymphocytic activation molecule (SLAM) family of transmembrane receptors that modulate the function of immune cells through immunoreceptor tyrosine-based switch motifs (ITSMs) and intracellular adaptor proteins. SLAMF7 is highly expressed on certain malignant plasma cells and is minimally expressed on healthy immune cells. Targeting the two different TAAs highly expressed on malignant plasma cells may improve coverage and protect against antigen escape and resistance as tumor cells would need to lose both antigens."], "t": []}], "preferred_name": "Autologous Anti-BCMA/CS1 Bispecific CAR-T Cells", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1979232", "l": "Blasts.CD34+CD117+", "d": [], "t": []}], "preferred_name": "Blasts.CD34+CD117+", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5157665", "l": "CD8 cells | XXX | Cell markers", "d": [], "t": []}], "preferred_name": "CD8 cells | XXX | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1517734", "l": "Large Multinucleated Erythroid Cell", "d": [], "t": []}, {"i": "NCIT:C37055", "l": "Large Multinucleated Erythroid Cell", "d": [], "t": []}], "preferred_name": "Large Multinucleated Erythroid Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 80.96785908349635, "identifiers": [{"i": "UMLS:C1514073", "l": "Neoplastic Prolymphocyte", "d": [], "t": []}, {"i": "NCIT:C37182", "l": "Neoplastic Prolymphocyte", "d": [], "t": []}], "preferred_name": "Neoplastic Prolymphocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1708895", "l": "Malignant Neuroendocrine Small to Intermediate Size Cell", "d": [], "t": []}, {"i": "NCIT:C45982", "l": "Malignant Neuroendocrine Small to Intermediate Size Cell", "d": [], "t": []}], "preferred_name": "Malignant Neuroendocrine Small to Intermediate Size Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 71.57077045273823, "identifiers": [{"i": "UMLS:C1515967", "l": "Anaplastic Large T-Lymphocyte", "d": [], "t": []}, {"i": "NCIT:C37017", "l": "Anaplastic Large T-Lymphocyte", "d": [], "t": []}], "preferred_name": "Anaplastic Large T-Lymphocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C4724902", "l": "Donor-derived Cytokine-induced Memory-like Natural Killer Cells", "d": [], "t": []}, {"i": "NCIT:C148213", "l": "Donor-derived Cytokine-induced Memory-like Natural Killer Cells", "d": ["A population of donor-derived cytokine-induced, memory-like, cytotoxic natural killer (NK) cells (CIML NKs), with potential antitumor activity. Allogeneic NK cells are pre-activated ex vivo with various cytokines, which induces the differentiation of the NK cells into CIML NK cells. The pretreated NK cells exhibit enhanced activation and interferon-gamma (IFN-g) responses, and may exert enhanced cytotoxicity against tumor cells. Upon administration, the CIML NKs may induce an anti-tumor immune response and kill tumor cells."], "t": []}], "preferred_name": "Donor-derived Cytokine-induced Memory-like Natural Killer Cells", "taxa": []}
{"type": "biolink:Cell", "ic": 76.9766555310214, "identifiers": [{"i": "UMLS:C1882059", "l": "Neoplastic Sex Cord-Stromal Cell Resembling Steroid Hormone-Secreting Cell", "d": [], "t": []}, {"i": "NCIT:C61450", "l": "Neoplastic Sex Cord-Stromal Cell Resembling Steroid Hormone-Secreting Cell", "d": [], "t": []}], "preferred_name": "Neoplastic Sex Cord-Stromal Cell Resembling Steroid Hormone-Secreting Cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4740205", "l": "Cells.TACI", "d": [], "t": []}], "preferred_name": "Cells.TACI", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C3494452", "l": "Central Pattern Generator Neurons", "d": [], "t": []}], "preferred_name": "Central Pattern Generator Neurons", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0001045", "l": "naive CCR4-positive regulatory T cell", "d": ["A naive regulatory T cell with the phenotype CD4-positive, CD25-positive, CD127lo, CCR4-positive, and CD45RO-negative."], "t": []}], "preferred_name": "naive CCR4-positive regulatory T cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5447676", "l": "Therapeutic Effector T-Lymphocytes", "d": [], "t": []}, {"i": "NCIT:C177284", "l": "Therapeutic Effector T-Lymphocytes", "d": ["A preparation of autologous or donor-derived T-lymphocytes that is able to mount an antigen-specific immune response."], "t": []}], "preferred_name": "Therapeutic Effector T-Lymphocytes", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "UMLS:C2828335", "l": "Balloon Melanoma Cell", "d": [], "t": []}, {"i": "NCIT:C62403", "l": "Balloon Melanoma Cell", "d": [], "t": []}], "preferred_name": "Balloon Melanoma Cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5174656", "l": "Neutrophils.vacuolated+Segmented | Blood | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Neutrophils.vacuolated+Segmented | Blood | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5163448", "l": "Eosinophils | Urine sediment | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Eosinophils | Urine sediment | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0002285", "l": "type III taste bud cell", "d": ["A taste receptor cell that is characterized by morphologically identifiable synaptic contacts with the gustatory nerve fibers and expression of the synaptic membrane protein-25 (SNAP-25) and NCAM."], "t": []}, {"i": "UMLS:C1180368", "l": "Type III taste bud cell", "d": [], "t": []}], "preferred_name": "type III taste bud cell", "taxa": []}
{"type": "biolink:Cell", "ic": 81.743421370964, "identifiers": [{"i": "CL:0000378", "l": "supporting cell (sensu Nematoda and Protostomia)", "d": [], "t": []}], "preferred_name": "supporting cell (sensu Nematoda and Protostomia)", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5163754", "l": "Erythrocytes.lytic resistant | Blood | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Erythrocytes.lytic resistant | Blood | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1292099", "l": "IgE B lymphocyte", "d": [], "t": []}, {"i": "SNOMEDCT:115605003", "l": "", "d": [], "t": []}], "preferred_name": "IgE B lymphocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1512133", "l": "ES04", "d": [], "t": []}, {"i": "NCIT:C20252", "l": "ES04", "d": ["Provider: ES Cell International Pte Ltd., Melbourne, Australia. Information from provider and not independently verified by NIH: Cells are positive for cell markers Oct-4, SSEA-4, TRA-1-60, GCTM-2, and alkaline phosphatase activity; Cells are negative for cell marker SSEA-1; Give rise to teratomas containing derivatives of three germ layers in SCID mice; Differentiate in vitro into extraembryonic and somatic cell lineages; Neural progenitor cells may be isolated from differentiating ES cell cultures and induced to form mature neurons; Available for distribution. This cell line meets the criteria for the use of human embryonic stem cells by federally funded researchers."], "t": []}], "preferred_name": "ES04", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C4086501", "l": "Human Umbilical Cord Perivascular Cell", "d": [], "t": []}, {"i": "NCIT:C124146", "l": "Human Umbilical Cord Perivascular Cell", "d": ["Mesenchymal stem cells isolated from umbilical cord blood capable of high proliferation potential and colony formation capacity in vitro and the ability to proliferate and differentiate to an osteogenic phenotype in culture."], "t": []}], "preferred_name": "Human Umbilical Cord Perivascular Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "CL:4042020", "l": "beta2-tanycyte", "d": ["A type of tanycyte located in the floor of third ventricle and the infindibular recess. This tanycyte has an elongated morphology with multiple microvilli extending medially and ventrally to the median eminence, contacting the pial surface and blood vessels. This type of tanycyte expresses FGF receptors 1 and 2, is in contact with GnRH neurons, and is involved in the release of gonadotropin-releasing hormone (GnRH)."], "t": []}], "preferred_name": "beta2-tanycyte", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C2350331", "l": "Retinal Neurons", "d": [], "t": []}, {"i": "MESH:D055351", "l": "Retinal Neurons", "d": [], "t": []}], "preferred_name": "Retinal Neurons", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1440231", "l": "BCL2+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:725310003", "l": "", "d": [], "t": []}], "preferred_name": "BCL2+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5161802", "l": "Cytoplasmic CD3 blasts | Bone marrow | Cell markers", "d": [], "t": []}], "preferred_name": "Cytoplasmic CD3 blasts | Bone marrow | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": 90.871710685482, "identifiers": [{"i": "CL:0000314", "l": "milk secreting cell", "d": [], "t": []}], "preferred_name": "milk secreting cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5854446", "l": "CAR-NK Cells SZ011", "d": [], "t": []}, {"i": "NCIT:C199633", "l": "CAR-NK Cells SZ011", "d": ["A preparation of natural killer cells (NKs) expressing a chimeric antigen receptor (CAR) specific for an as of yet undisclosed tumor-associated antigen (TAA), with potential immunomodulating and antineoplastic activities. Upon administration, the CAR-NK cells SZ011 recognize and induce selective cytotoxicity in tumor cells expressing the TAA."], "t": []}], "preferred_name": "CAR-NK Cells SZ011", "taxa": []}
{"type": "biolink:Cell", "ic": 89.40238429118027, "identifiers": [{"i": "UMLS:C1514079", "l": "Neoplastic Round Neuroepithelial Cell", "d": [], "t": []}, {"i": "NCIT:C42092", "l": "Neoplastic Round Neuroepithelial Cell", "d": [], "t": []}], "preferred_name": "Neoplastic Round Neuroepithelial Cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C3176904", "l": "CD3+CD5+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:1373011008", "l": "", "d": [], "t": []}], "preferred_name": "CD3+CD5+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5157500", "l": "CD34+DR+ | White blood cells | Cell markers", "d": [], "t": []}], "preferred_name": "CD34+DR+ | White blood cells | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5382575", "l": "Cells.CD8.PMA+ionomycin stimulated CD107a+b expressing", "d": [], "t": []}], "preferred_name": "Cells.CD8.PMA+ionomycin stimulated CD107a+b expressing", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1955382", "l": "Spermatozoa.immature", "d": [], "t": []}], "preferred_name": "Spermatozoa.immature", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5853562", "l": "OTL-203", "d": [], "t": []}, {"i": "NCIT:C204810", "l": "Autologous CD34+ enriched Alpha-L-iduronidase-expressing Hematopoietic Stem Cells OTL-203", "d": ["A gene therapy agent composed of a preparation of autologous CD34-enriched hematopoietic stem cells (HSCs) transduced with a lentiviral vector expressing the endogenous human gene alpha-L-iduronidase (IDUA), that may potentially be used in the treatment of mucopolysaccharidosis type I (MPS I; Hurler syndrome). Upon administration, autologous CD34+ enriched IDUA-expressing HSCs OTL-203 express IDUA, which is an enzyme required for the lysosomal degradation of glycosaminoglycans (GAGs). IDUA hydrolyzes the non-reducing terminal alpha-L-iduronic acid residues in GAGs, including dermatan sulfate and heparan sulfate. IDUA deficiency causes accumulations of heparan sulfate and dermatan sulfate in various organs of the body which leads to progressive damage. Mutations in the IDUA gene are responsible for the deficiency of IDUA."], "t": []}], "preferred_name": "OTL-203", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4696681", "l": "CD19+CD38+IgM- cell", "d": [], "t": []}, {"i": "SNOMEDCT:1373238006", "l": "", "d": [], "t": []}], "preferred_name": "CD19+CD38+IgM- cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4033154", "l": "jugular ganglion SP neuron", "d": ["A sensory neuron that has the soma located in the jugular ganglion and expresses the marker substance P (SP)."], "t": []}], "preferred_name": "jugular ganglion SP neuron", "taxa": []}
{"type": "biolink:Cell", "ic": 72.9312568671559, "identifiers": [{"i": "CL:1000507", "l": "kidney tubule cell", "d": ["A cell that is part of a nephron tubule."], "t": []}], "preferred_name": "kidney tubule cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C2340284", "l": "Differentiated hemal cell", "d": [], "t": []}], "preferred_name": "Differentiated hemal cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0000877", "l": "splenic tingible body macrophage", "d": ["A splenic white pulp macrophage found in and around the germinal centers of the white pulp of the spleen that participates in phagocytosis of apoptotic B cells from the germinal centers. A marker for a cell of this type is Mertk-positive."], "t": []}], "preferred_name": "splenic tingible body macrophage", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "CL:1000839", "l": "kidney proximal straight tubule epithelial cell", "d": ["Any epithelial cell of proximal tubule that is part of some proximal straight tubule."], "t": []}], "preferred_name": "kidney proximal straight tubule epithelial cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:2000065", "l": "ovarian microvascular endothelial cell", "d": ["Any microvascular endothelial cell that is part of a female urethra."], "t": []}], "preferred_name": "ovarian microvascular endothelial cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:2000014", "l": "fibroblast of upper leg skin", "d": ["Any skin fibroblast that is part of a upper leg skin."], "t": []}], "preferred_name": "fibroblast of upper leg skin", "taxa": []}
{"type": "biolink:Cell", "ic": 92.76600187037766, "identifiers": [{"i": "CL:0002220", "l": "interstitial cell of pineal gland", "d": ["A cell located between the pinealocytes."], "t": []}, {"i": "UMLS:C1512902", "l": "Interstitial cell of pineal gland", "d": [], "t": []}, {"i": "NCIT:C32872", "l": "Interstitial Cell of the Pineal Gland", "d": ["A non-neuronal cell that supports the pineal gland. It resembles an astrocyte and is found around blood vessels and among groups of pinealocytes. The nucleus is small, elongated and darkly stained."], "t": []}], "preferred_name": "interstitial cell of pineal gland", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0022686", "l": "Killer Cells", "d": [], "t": []}], "preferred_name": "Killer Cells", "taxa": []}
{"type": "biolink:Cell", "ic": 69.87704306295657, "identifiers": [{"i": "UMLS:C1709179", "l": "Neoplastic Histiocytic and Dendritic Cell", "d": [], "t": []}, {"i": "NCIT:C43253", "l": "Neoplastic Histiocytic and Dendritic Cell", "d": [], "t": []}], "preferred_name": "Neoplastic Histiocytic and Dendritic Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 80.27409497666227, "identifiers": [{"i": "CL:0002631", "l": "epithelial cell of upper respiratory tract", "d": ["Any epithelial cell that is part of some upper respiratory tract epithelium."], "t": []}], "preferred_name": "epithelial cell of upper respiratory tract", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C4733604", "l": "Genetically-modified Anti-HER2-CAR-CD28zeta-expressing Allogeneic NK-92/5.28.z Cells", "d": [], "t": []}, {"i": "NCIT:C154568", "l": "Genetically-modified Anti-HER2-CAR-CD28zeta-expressing Allogeneic NK-92/5.28.z Cells", "d": ["A preparation of genetically-modified natural killer (NK) cells derived from the allogeneic NK-92 cell line that are transduced with a lentiviral vector expressing a codon-optimized chimeric antigen receptor (CAR) consisting of a single chain variable fragment (scFv) of the anti-human epidermal growth factor 2 (HER2; ErbB2) monoclonal antibody FRP5, and fused, via hinge and transmembrane regions, to the intracellular domain of the costimulatory molecule CD28, and the intracellular signaling domain of the T-cell antigen receptor complex zeta chain (CD3-zeta), with potential cytolytic, immunomodulating and antineoplastic activities. Upon infusion of the genetically modified anti-HER2-CAR-CD28zeta-expressing allogeneic NK-92/5.28.z cells, the NK cells recognize and bind to HER2 expressed on tumor cells. This leads to the secretion and release of perforins, granzymes, cytokines and chemokines, which results in selective tumor cell lysis in HER2-expressing tumor cells. HER2, a receptor tyrosine kinase (RTK) mutated or overexpressed in many tumor cell types, plays a significant role in tumor cell proliferation and tumor vascularization. The NK-92 cells are derived from a human cytotoxic cell line composed of allogeneic, activated, interleukin-2-(IL-2) dependent-NK cells from a 50-year old male patient with rapidly progressive non-Hodgkin's lymphoma. As NK-92 cells are devoid of killer inhibitory receptors (KIRs; also called killer cell immunoglobulin-like receptors), which are negative regulators of NK cell activity, cancer cells are unable to suppress the cancer cell killing ability of the NK-92 cells."], "t": []}], "preferred_name": "Genetically-modified Anti-HER2-CAR-CD28zeta-expressing Allogeneic NK-92/5.28.z Cells", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4304497", "l": "Population of all dacryocytes in portion of fluid", "d": [], "t": []}, {"i": "SNOMEDCT:719691002", "l": "", "d": [], "t": []}], "preferred_name": "Population of all dacryocytes in portion of fluid", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0000041", "l": "mature eosinophil", "d": ["A fully differentiated eosinophil, a granular leukocyte with a nucleus that usually has two lobes connected by one or more slender threads, and cytoplasm containing coarse, round granules that are uniform in size and which can be stained by the dye eosin. Cells are also differentiated from other granulocytes by a small nuclear-to-cytoplasm ratio (1:3). This cell type is CD49d-positive."], "t": []}], "preferred_name": "mature eosinophil", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0229604", "l": "Reticuloendothelial cell", "d": [], "t": []}, {"i": "SNOMEDCT:27604002", "l": "", "d": [], "t": []}], "preferred_name": "Reticuloendothelial cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5983420", "l": "Zolacabtagene Autoleucel", "d": [], "t": []}], "preferred_name": "Zolacabtagene Autoleucel", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5834402", "l": "Autologous T-cells transfected with PiggyBac transposon plasmid vector expressing B-cell maturation antigen (CAR-T cells)", "d": [], "t": []}], "preferred_name": "Autologous T-cells transfected with PiggyBac transposon plasmid vector expressing B-cell maturation antigen (CAR-T cells)", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4072039", "l": "L4 intratelencephalic projecting glutamatergic neuron (Homo sapiens)", "d": ["A transcriptomically distinct intratelencephalic-projecting glutamatergic neuron with a soma found in cortical layer 3-4. This neuron type can have a pyramidal, star-pyramidal or spiny stellate morphology and projects its output to L2/3 and L5A/B. The standard transcriptomic reference data for this cell type can be found on the CellxGene census under the collection: 'Transcriptomic cytoarchitecture reveals principles of human neocortex organization', dataset: 'Supercluster: IT-projecting excitatory neurons', Author Categories: 'CrossArea_subclass', L4 IT."], "t": []}], "preferred_name": "L4 intratelencephalic projecting glutamatergic neuron (Homo sapiens)", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0002348", "l": "CD27-low, CD11b-high natural killer cell, mouse", "d": ["A CD27-low, CD11b-high natural killer cell that has a higher threshold of activation due to higher expression of inhibitory receptors."], "t": []}], "preferred_name": "CD27-low, CD11b-high natural killer cell, mouse", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5420488", "l": "Allogeneic Anti-BCMA/CS1 Bispecific CAR-T Cells", "d": [], "t": []}, {"i": "NCIT:C173967", "l": "Allogeneic Anti-BCMA/CS1 Bispecific CAR-T Cells", "d": ["A preparation of allogeneic T-lymphocytes that have been genetically modified to express a chimeric antigen receptor (CAR) targeting both the tumor-associated antigens (TAAs) B-cell maturation antigen (BCMA; TNFRSF17) and human CS1 (CD2 subset 1; SLAM family member 7; SLAMF7; CD319; CRACC), with potential immunomodulating and antineoplastic activities. Upon administration, the allogeneic anti-BCMA/CS1 bispecific CAR-T cells target and bind to tumor cells expressing BCMA and/or CS1 and induce selective cytotoxicity in those cells. BCMA, a receptor for both a proliferation-inducing ligand (APRIL) and B-cell activating factor (BAFF), is a member of the tumor necrosis factor receptor superfamily (TNFRSF). BCMA is found on the surfaces of plasma cells, is overexpressed on malignant plasma cells and plays a key role in plasma cell proliferation and survival. SLAMF7 is a member of the signaling lymphocytic activation molecule (SLAM) family of transmembrane receptors that modulate the function of immune cells through immunoreceptor tyrosine-based switch motifs (ITSMs) and intracellular adaptor proteins. SLAMF7 is highly expressed on certain malignant plasma cells and is minimally expressed on healthy immune cells. Targeting the two different TAAs highly expressed on malignant plasma cells may improve coverage and protect against antigen escape and resistance as tumor cells would need to lose both antigens."], "t": []}], "preferred_name": "Allogeneic Anti-BCMA/CS1 Bispecific CAR-T Cells", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C4084729", "l": "Cardiac Stem Cell", "d": [], "t": []}, {"i": "NCIT:C124143", "l": "Cardiac Stem Cell", "d": ["Multipotent progenitor cells that are found in the fetal and adult heart that provide the myocardium with limited regenerating capability."], "t": []}], "preferred_name": "Cardiac Stem Cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0682543", "l": "cell by staining properties", "d": [], "t": []}], "preferred_name": "cell by staining properties", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0483182", "l": "CD16+CD56+CD3-", "d": [], "t": []}], "preferred_name": "CD16+CD56+CD3-", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5783869", "l": "Allogeneic Anti-HA-1 TCR-engineered T-cells TSC-100", "d": [], "t": []}, {"i": "NCIT:C190701", "l": "Allogeneic Anti-HA-1 TCR-engineered T-cells TSC-100", "d": ["A preparation of donor-derived T-lymphocytes that have been genetically engineered to express a T-cell receptor (TCR) specific for HLA-A*02:01-restricted minor histocompatibility antigen HA-1 (HA1), with potential immunomodulating and antineoplastic activities. Following allogeneic haploidentical hematopoietic cell transplantation (HCT) in HLA-A*02:01 positive patients, allogeneic anti-HA-1 TCR-engineered T-cells TSC-100 specifically recognize and bind to HA-1 expressed on tumor cells. This may lead to cytotoxic T-lymphocyte (CTL)-mediated elimination of tumor cells expressing HA-1. HA-1 is a lineage-specific antigen found on leukemia cells."], "t": []}], "preferred_name": "Allogeneic Anti-HA-1 TCR-engineered T-cells TSC-100", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1440832", "l": "Islet cell 512", "d": [], "t": []}], "preferred_name": "Islet cell 512", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C4723770", "l": "Autologous Natural Killer Cell-like CTLs", "d": [], "t": []}, {"i": "NCIT:C156168", "l": "Autologous Natural Killer Cell-like CTLs", "d": ["A preparation of cytotoxic T-lymphocytes (CTLs) that express natural killer (NK)-like features (nCTLs), with potential immunomodulating and antineoplastic activities. The nCTLs are derived from autologous lymphocytes that have been in vitro exposed to autologous alpha-type-1 polarized dendritic cells that are pulsed with specific autologous tumor-associated antigens (TAAs); the nCTLs are subsequently expanded in the presence of the cytokine human interleukin-2 (IL-2). The generated nCTLs are potent CTLs that produce high amounts of granzyme B and perforin, and interferon-gamma (IFNg) with high killer activity and tumor-homing potential. Upon infusion of the autologous nCTLs, these cells specifically recognize the TAAs on the tumor cells, then bind to and directly lyse tumor cells."], "t": []}], "preferred_name": "Autologous Natural Killer Cell-like CTLs", "taxa": []}
{"type": "biolink:Cell", "ic": 89.40238429118027, "identifiers": [{"i": "CL:0009115", "l": "lymph node lymphatic vessel endothelial cell", "d": ["An endothelial cell located in a lymph node lymphatic vessel."], "t": []}], "preferred_name": "lymph node lymphatic vessel endothelial cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1267924", "l": "Lymphocyte positive for CD42D antigen", "d": [], "t": []}, {"i": "SNOMEDCT:117368009", "l": "", "d": [], "t": []}], "preferred_name": "Lymphocyte positive for CD42D antigen", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C4725791", "l": "Allogeneic T-lymphocytes Expressing NY-ESO-1-C259-specific TCR", "d": [], "t": []}, {"i": "NCIT:C150511", "l": "Allogeneic T-lymphocytes Expressing NY-ESO-1-C259-specific TCR", "d": ["Genetically engineered human allogeneic T-lymphocytes that are transduced with a retroviral vector encoding a T-cell receptor (TCR) specific for the cancer/testis antigen NY-ESO-1, with potential antineoplastic activity. Upon isolation, transduction, expansion ex vivo and introduction into the patient, the allogeneic T-lymphocytes expressing NY-ESO-1-C259-specific TCR specifically target and bind to NY-ESO-1-overexpressing tumor cells. This may result in the specific cytotoxic T-lymphocyte (CTL) killing of NY-ESO-1-positive cancer cells. NY-ESO-1, a tumor-associated antigen (TAA), is expressed in normal testis and on the surface of various tumor cell types."], "t": []}], "preferred_name": "Allogeneic T-lymphocytes Expressing NY-ESO-1-C259-specific TCR", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0009097", "l": "embryonic skeletal muscle fiber", "d": ["A skeletal muscle fiber found in an embryo. In mammalian embryos, skeletal muscle expresses myosin heavy chain-embryonic (MyHC-emb, encoded by the MYH3 gene), which regulates skeletal muscle development."], "t": []}], "preferred_name": "embryonic skeletal muscle fiber", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5157240", "l": "CD10+CD20+ cells | Blood | Cell markers", "d": [], "t": []}], "preferred_name": "CD10+CD20+ cells | Blood | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5854597", "l": "Autologous Tumor Infiltrating Lymphocytes HV-101", "d": [], "t": []}, {"i": "NCIT:C200810", "l": "Autologous Tumor Infiltrating Lymphocytes HV-101", "d": ["A preparation of autologous tumor infiltrating lymphocytes (TILs) derived from each patient's resected tumor and expanded ex vivo, with potential immunomodulating and antineoplastic activities. Upon administration back into the patient, autologous TILs HV-101 specifically recognize and kill the patient's tumor cells."], "t": []}], "preferred_name": "Autologous Tumor Infiltrating Lymphocytes HV-101", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5848429", "l": "Taniraleucel", "d": [], "t": []}], "preferred_name": "Taniraleucel", "taxa": []}
{"type": "biolink:Cell", "ic": 78.29800561113302, "identifiers": [{"i": "CL:0002064", "l": "pancreatic acinar cell", "d": ["A secretory cell found in pancreatic acini that secretes digestive enzymes and mucins. This cell is a typical zymogenic cell, have a basal nucleus and basophilic cytoplasm consisting of regular arrays of granular endoplasmic reticulum with mitochondria and dense secretory granules."], "t": []}, {"i": "UMLS:C1179517", "l": "Acinar cell of pancreas", "d": [], "t": []}, {"i": "NCIT:C174117", "l": "Pancreatic Acinar Cell", "d": ["A cell which secretes digestive enzymes via the pancreatic duct into the duodenum to assist in digestion."], "t": []}], "preferred_name": "pancreatic acinar cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0314594", "l": "Colony-forming unit, monocyte", "d": [], "t": []}], "preferred_name": "Colony-forming unit, monocyte", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4699465", "l": "Monotypic lambda plasma cells", "d": [], "t": []}], "preferred_name": "Monotypic lambda plasma cells", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0003034", "l": "M5 retinal ganglion cell", "d": ["A monostratified retinal ganglion cell that has a small soma, an assymetric dendritic field with post synaptic terminals in sublaminar layer S3."], "t": []}], "preferred_name": "M5 retinal ganglion cell", "taxa": []}
{"type": "biolink:Cell", "ic": 75.2337427109536, "identifiers": [{"i": "UMLS:C1513992", "l": "Neoplastic Intermediate Type Trophoblastic Cell", "d": [], "t": []}, {"i": "NCIT:C37142", "l": "Neoplastic Intermediate Type Trophoblastic Cell", "d": [], "t": []}], "preferred_name": "Neoplastic Intermediate Type Trophoblastic Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5419893", "l": "Autologous UCD19 CAR T Cells", "d": [], "t": []}, {"i": "NCIT:C172841", "l": "Autologous UCD19 CAR T Cells", "d": ["A preparation of autologous peripheral blood lymphocytes (PBLs) that have been transduced with a lentiviral vector to express a chimeric antigen receptor (CAR) targeting the tumor-associated antigen (TAA) CD19, with potential immunostimulating and antineoplastic activities. Upon transfusion, the autologous UCD19 CAR T-cells recognize and bind to CD19-expressing tumor cells, thereby selectively lysing CD19-expressing tumor cells. CD19, a B-cell-specific cell surface antigen is overexpressed in B-cell lineage malignancies."], "t": []}], "preferred_name": "Autologous UCD19 CAR T Cells", "taxa": []}
{"type": "biolink:Cell", "ic": 84.83823963392128, "identifiers": [{"i": "UMLS:C1882961", "l": "Round Adenocarcinoma Cell", "d": [], "t": []}, {"i": "NCIT:C54417", "l": "Round Adenocarcinoma Cell", "d": [], "t": []}], "preferred_name": "Round Adenocarcinoma Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0002514", "l": "Vgamma5-negative CD8-alpha alpha positive gamma-delta intraepithelial T cell", "d": ["A CD8-alpha alpha positive gamma-delta intraepithelial T cell that does not express a TCR partially encoded by the Vgamma5 gene segment."], "t": []}], "preferred_name": "Vgamma5-negative CD8-alpha alpha positive gamma-delta intraepithelial T cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5401594", "l": "Placental Mesenchymal Stem Cells", "d": [], "t": []}], "preferred_name": "Placental Mesenchymal Stem Cells", "taxa": []}
{"type": "biolink:Cell", "ic": 80.27409497666227, "identifiers": [{"i": "CL:0000519", "l": "phagocyte (sensu Nematoda and Protostomia)", "d": ["A phagocyte from organisms in the Nematoda or Protostomia clades."], "t": []}], "preferred_name": "phagocyte (sensu Nematoda and Protostomia)", "taxa": []}
{"type": "biolink:Cell", "ic": 67.65179433958558, "identifiers": [{"i": "CL:1001474", "l": "medium spiny neuron", "d": ["An inhibitory, GABAergic projection neuron in the striatum that integrates glutamatergic signals arising from the cerebral cortex and thalamus."], "t": []}, {"i": "UMLS:C5690793", "l": "Medium Spiny Neurons", "d": [], "t": []}, {"i": "MESH:D000094242", "l": "Medium Spiny Neurons", "d": [], "t": []}], "preferred_name": "medium spiny neuron", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1184144", "l": "Luminal cell of alveolus of lactiferous gland", "d": [], "t": []}], "preferred_name": "Luminal cell of alveolus of lactiferous gland", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0677646", "l": "crypt cell", "d": [], "t": []}], "preferred_name": "crypt cell", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "CL:1000415", "l": "epithelial cell of gallbladder", "d": ["An epithelial cell that is part of the gallbladder."], "t": []}, {"i": "UMLS:C1180254", "l": "Epithelial cell of gallbladder", "d": [], "t": []}], "preferred_name": "epithelial cell of gallbladder", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5418086", "l": "Allogeneic Third-party Suicide Gene-transduced Anti-HLA-DPB1*0401 CD4+ T-cells CTL 19", "d": [], "t": []}, {"i": "NCIT:C174401", "l": "Allogeneic Third-party Suicide Gene-transduced Anti-HLA-DPB1*0401 CD4+ T-cells CTL 19", "d": ["A preparation of allogeneic, third-party, CD4+ T-lymphocytes that specifically recognizes the human leukocyte antigen (HLA)-DPB1*0401 and transduced with a suicide gene, with potential antineoplastic activity. Upon administration, allogeneic third-party suicide gene-transduced anti-HLA-DPB1*0401 CD4+ T-cells CTL 19 specifically target and kill HLA-DPB1*0401-positive leukemic cells. The suicide gene causes the destruction of the T-cell clone upon the administration and presence of ganciclovir, which enhances the safety of the agent. HLA-DP is expressed by many leukemic cells."], "t": []}], "preferred_name": "Allogeneic Third-party Suicide Gene-transduced Anti-HLA-DPB1*0401 CD4+ T-cells CTL 19", "taxa": []}
{"type": "biolink:Cell", "ic": 69.54608552448124, "identifiers": [{"i": "UMLS:C1708862", "l": "Malignant Cell with Eosinophilic Cytoplasm", "d": [], "t": []}, {"i": "NCIT:C53644", "l": "Malignant Cell with Eosinophilic Cytoplasm", "d": [], "t": []}], "preferred_name": "Malignant Cell with Eosinophilic Cytoplasm", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C3179121", "l": "Human Umbilical Vein Endothelial Cells", "d": [], "t": []}, {"i": "MESH:D061307", "l": "Human Umbilical Vein Endothelial Cells", "d": [], "t": []}], "preferred_name": "Human Umbilical Vein Endothelial Cells", "taxa": []}
{"type": "biolink:Cell", "ic": 80.27409497666227, "identifiers": [{"i": "UMLS:C1512477", "l": "Hodgkin-Like Cell", "d": [], "t": []}, {"i": "NCIT:C37026", "l": "Hodgkin-Like Cell", "d": [], "t": []}], "preferred_name": "Hodgkin-Like Cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0552337", "l": "bladder cells", "d": [], "t": []}], "preferred_name": "bladder cells", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0000436", "l": "vaginal lubricant secreting cell", "d": [], "t": []}], "preferred_name": "vaginal lubricant secreting cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5172548", "l": "Metamyelocytes | Cerebral spinal fluid | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Metamyelocytes | Cerebral spinal fluid | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4052066", "l": "mucous acinar cell of salivary gland", "d": ["An acinar cell of the salivary gland, responsible for producing a viscous, mucin‐rich solution, thereby facilitating lubrication and protection of the oral mucosa. This cell is characterized by an elongated shape, clear cytoplasm filled with mucin granules, and a basally compressed nucleus (Barrows et al., 2020). In humans and mice, the mucous acinar cell predominates in the sublingual gland and minor salivary glands, while also being present in mixed glands such as the submandibular gland, where it coexists with serous acinar cells (Maruyama et al., 2019)."], "t": []}], "preferred_name": "mucous acinar cell of salivary gland", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1979010", "l": "CD38+CD138+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:1373023002", "l": "", "d": [], "t": []}], "preferred_name": "CD38+CD138+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0815000", "l": "neuroblastoma cell", "d": [], "t": []}], "preferred_name": "neuroblastoma cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0933799", "l": "Ciliated columnar cell", "d": [], "t": []}], "preferred_name": "Ciliated columnar cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4323413", "l": "Set of rod cells of inner nuclear layer", "d": [], "t": []}], "preferred_name": "Set of rod cells of inner nuclear layer", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4307051", "l": "Astro-OLF NN_1 Greb1 astrocyte (Mmus)", "d": ["A astrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Gja1 (Mmus), Chrdl1 (Mmus), Ano1 (Mmus), Il33 (Mmus). It is distinguished from other Astro-OLF NN_1 cells by expression of Greb1, Il33. These cells are located in the Olfactory areas, brain , in or close to the regions: Main olfactory bulb . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5231 Astro-OLF NN_1."], "t": []}], "preferred_name": "Astro-OLF NN_1 Greb1 astrocyte (Mmus)", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1518125", "l": "MI01", "d": [], "t": []}, {"i": "NCIT:C20279", "l": "MI01", "d": ["Provider: MizMedi Hospital - Seoul National University, Seoul, Korea. No information from provider. This cell line meets the criteria for the use of human embryonic stem cells by federally funded researchers."], "t": []}], "preferred_name": "MI01", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0010016", "l": "collar cell", "d": ["A cell with a flagellum surrounded by a collar of microvilli. The motion of the flagellum draws water past the microvilli, serving either a feeding or sensory function. Collar cells are found in multiple animals, including sponges, echinoderms, and cnidarians. They are also found outside animals in the choanoflagellates. Although collar cells are superficially similar, their cytoskeletal structure and functional biology are different in different groups of organisms."], "t": []}], "preferred_name": "collar cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0009086", "l": "endothelial cell of respiratory system lymphatic vessel", "d": ["An endothelial cell that is part of a respiratory system lymphatic vessel."], "t": []}], "preferred_name": "endothelial cell of respiratory system lymphatic vessel", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4038495", "l": "Cells.aneuploid.S phase population", "d": [], "t": []}], "preferred_name": "Cells.aneuploid.S phase population", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0000887", "l": "lymph node subcapsular sinus macrophage", "d": ["A lymph node macrophage found in the subcapsular sinus of lymph nodes that participates in sensing, clearance, and antigen presentation of lymph-borne particulate antigens. This macrophage is capable of activating invaraint NKT cells and is CD169-positive."], "t": []}], "preferred_name": "lymph node subcapsular sinus macrophage", "taxa": []}
{"type": "biolink:Cell", "ic": 92.76600187037766, "identifiers": [{"i": "CL:0002158", "l": "external epithelial cell of tympanic membrane", "d": ["Epithelial cell found on the external side of the tympanic membrane"], "t": []}, {"i": "UMLS:C1182617", "l": "External epithelial cell of tympanic membrane", "d": [], "t": []}], "preferred_name": "external epithelial cell of tympanic membrane", "taxa": []}
{"type": "biolink:Cell", "ic": 70.59347386640042, "identifiers": [{"i": "UMLS:C1518180", "l": "Malignant Epithelioid Cell", "d": [], "t": []}, {"i": "NCIT:C41435", "l": "Malignant Epithelioid Cell", "d": [], "t": []}], "preferred_name": "Malignant Epithelioid Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4079019", "l": "lumbar dorsal root ganglion TRPV1 neuron", "d": ["A polymodal nociceptor whose soma is located in the lumbar dorsal root ganglion and that expresses the transient receptor potential vanilloid 1 channel (TRPV1, encoded by TRPV1). This neuron detects noxious heat above 43 degrees Celsius, protons, and endogenous lipid mediators, and is activated by capsaicin. In human DRG, TRPV1-immunoreactive neurons constitute approximately 54% of TrkA-positive neurons, significantly higher than the 35% observed in mouse (Rostock et al. 2018, PMID:29229553). These neurons are predominantly small-diameter nociceptors that innervate skin and visceral organs, where they function as primary detectors of thermal and chemical noxious stimuli."], "t": []}], "preferred_name": "lumbar dorsal root ganglion TRPV1 neuron", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1317197", "l": "CD4+CD45RO+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:1373156004", "l": "", "d": [], "t": []}], "preferred_name": "CD4+CD45RO+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "CL:0000724", "l": "heterocyst", "d": ["A differentiated cell that functions as a site of nitrogen fixation under aerobic conditions."], "t": []}], "preferred_name": "heterocyst", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "CL:0002227", "l": "nucleated secondary lens fiber", "d": ["A secondary fiber cell that contains a nucleus."], "t": []}, {"i": "UMLS:C1182775", "l": "Nucleated secondary lens fiber", "d": [], "t": []}], "preferred_name": "nucleated secondary lens fiber", "taxa": []}
{"type": "biolink:Cell", "ic": 67.09501193950672, "identifiers": [{"i": "CL:4023168", "l": "somatosensory neuron", "d": ["A neuron that is part of the somatic sensory system. Somatosensory neurons innervate the skin or integument to detect different types of thermal, chemical, and mechanical touch stimuli."], "t": []}], "preferred_name": "somatosensory neuron", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5157272", "l": "CD11c cells | Blood | Cell markers", "d": [], "t": []}], "preferred_name": "CD11c cells | Blood | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0002528", "l": "mature CD14-positive dermal dendritic cell", "d": ["A mature CD14-positive dermal dendritic cell is CD80-high, CD86-high, MHCII-high and is CD83-positive."], "t": []}], "preferred_name": "mature CD14-positive dermal dendritic cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4047037", "l": "stomach smooth muscle inner oblique layer cell", "d": ["A smooth muscle cell found in the innermost layer of the muscularis externa of the stomach wall. This cell forms a unique layer of smooth muscle fibers oriented obliquely to the stomach's longitudinal axis. It is responsible for aiding in the mixing and churning of gastric contents, contributing to mechanical digestion within the stomach."], "t": []}], "preferred_name": "stomach smooth muscle inner oblique layer cell", "taxa": []}
{"type": "biolink:Cell", "ic": 77.38833137893549, "identifiers": [{"i": "CL:0000205", "l": "thermoreceptor cell", "d": ["A cellular receptor which mediates the sense of temperature. Thermoreceptor cells in vertebrates are mostly located under the skin. In mammals there are separate types of thermoreceptors for cold and for warmth and pain receptor cells which detect cold or heat extreme enough to cause pain."], "t": []}, {"i": "UMLS:C0039821", "l": "Thermoreceptors", "d": [], "t": []}, {"i": "NCIT:C13822", "l": "Thermoreceptor", "d": ["A type of somatosensory receptor located mostly in the skin that detects changes in temperature; there are two classes of thermoreceptors: cold receptors and warm receptors."], "t": []}, {"i": "MESH:D013823", "l": "Thermoreceptors", "d": [], "t": []}, {"i": "UBERON:0035018", "l": "thermoreceptor", "d": ["Cellular receptors which mediate the sense of temperature. Thermoreceptors in vertebrates are mostly located under the skin. In mammals there are separate types of thermoreceptors for cold and for warmth and NOCICEPTORS which detect cold or heat extreme enough to cause pain."], "t": []}], "preferred_name": "thermoreceptor cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5163544", "l": "Epithelial cells | Vaginal | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Epithelial cells | Vaginal | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4033127", "l": "lower airway ganglion ChAT/VIP neuron", "d": ["A parasympathetic neuron that has the soma located in the lower airway ganglion and expresses the marker choline O-acetyltransferase (ChAT) and vasoactive intestinal peptide (VIP)."], "t": []}], "preferred_name": "lower airway ganglion ChAT/VIP neuron", "taxa": []}
{"type": "biolink:Cell", "ic": 92.76600187037766, "identifiers": [{"i": "CL:0000868", "l": "lymph node macrophage", "d": ["A secondary lymphoid organ macrophage found in a lymph node. This cell is CD169-high."], "t": []}], "preferred_name": "lymph node macrophage", "taxa": []}
{"type": "biolink:Cell", "ic": 70.22551955196433, "identifiers": [{"i": "CL:0000681", "l": "radial glial cell", "d": ["A cell present in the developing CNS. Functions as both a precursor cell and as a scaffold to support neuronal migration."], "t": []}, {"i": "UMLS:C3661481", "l": "Radial Glial Cells", "d": [], "t": []}], "preferred_name": "radial glial cell", "taxa": []}
{"type": "biolink:Cell", "ic": 74.11023018174025, "identifiers": [{"i": "CL:0000771", "l": "eosinophil", "d": ["Any of the immature or mature forms of a granular leukocyte with a nucleus that usually has two lobes connected by one or more slender threads of chromatin, and cytoplasm containing coarse, round granules that are uniform in size and which can be stained by the dye eosin. Eosinophils are CD9-positive, CD191-positive, and CD193-positive."], "t": []}, {"i": "UMLS:C0014467", "l": "eosinophil", "d": [], "t": []}, {"i": "NCIT:C12532", "l": "Eosinophil", "d": ["Granular leukocytes with a nucleus that usually has two lobes connected by a slender thread of chromatin, and cytoplasm containing coarse, round granules that are uniform in size and stainable by eosin."], "t": []}, {"i": "MESH:D004804", "l": "Eosinophils", "d": [], "t": []}, {"i": "SNOMEDCT:14793004", "l": "", "d": [], "t": []}], "preferred_name": "eosinophil", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1440244", "l": "CD118+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:1372825004", "l": "", "d": [], "t": []}], "preferred_name": "CD118+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4484193", "l": "Neutrophil.PMA stimulated.DHR", "d": [], "t": []}], "preferred_name": "Neutrophil.PMA stimulated.DHR", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1512130", "l": "ES01 (cell line)", "d": [], "t": []}, {"i": "NCIT:C20249", "l": "ES01", "d": ["Provider: ES Cell International Pte Ltd., Melbourne, Australia. Information from provider and not independently verified by NIH: Cells are positive for cell markers Oct-4, SSEA-4, TRA-1-60, GCTM-2, and alkaline phosphatase activity; Cells are negative for cell marker SSEA-1; Give rise to teratomas containing derivatives of three germ layers in SCID mice; Differentiate in vitro into extraembryonic and somatic cell lineages; Neural progenitor cells may be isolated from differentiating ES cell cultures and induced to form mature neurons; Available for distribution. This cell line meets the criteria for the use of human embryonic stem cells by federally funded researchers."], "t": []}], "preferred_name": "ES01 (cell line)", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0004236", "l": "AB broad diffuse-2 amacrine cell", "d": ["An amacrine cell with a medium dendritic field and post-synaptic terminals in S2, S3, and S4. This cell type releases the neurotransmitter gamma-aminobutyric acid (GABA)."], "t": []}], "preferred_name": "AB broad diffuse-2 amacrine cell", "taxa": []}
{"type": "biolink:Cell", "ic": 86.30756602822301, "identifiers": [{"i": "CL:0004250", "l": "bistratified retinal amacrine cell", "d": ["An amicrine that stratifies dendrites at two and only two locations."], "t": []}], "preferred_name": "bistratified retinal amacrine cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5173471", "l": "Monocytes+Macrophages | Pleural fluid | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Monocytes+Macrophages | Pleural fluid | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4072038", "l": "L5 intratelencephalic projecting glutamatergic neuron (Homo sapiens)", "d": ["An intratelencephalic-projecting glutamatergic neuron with a soma found in cortical layer 5. The standard transcriptomic reference data for this cell type can be found on the CellxGene census under the collection: 'Transcriptomic cytoarchitecture reveals principles of human neocortex organization', dataset: 'Supercluster: IT-projecting excitatory neurons', Author Categories: 'CrossArea_subclass', L5 IT."], "t": []}], "preferred_name": "L5 intratelencephalic projecting glutamatergic neuron (Homo sapiens)", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0004139", "l": "retinal ganglion cell A2 outer", "d": ["A retinal ganglion A2 cell with dendrites terminating in S2."], "t": []}], "preferred_name": "retinal ganglion cell A2 outer", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5157521", "l": "CD3-CD16+CD56+ (Natural killer) cells | Tissue and Smears | Cell markers", "d": [], "t": []}], "preferred_name": "CD3-CD16+CD56+ (Natural killer) cells | Tissue and Smears | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5157546", "l": "CD4+CD45RA+CD45RB+CD45RC+ cells | Bone marrow | Cell markers", "d": [], "t": []}], "preferred_name": "CD4+CD45RA+CD45RB+CD45RC+ cells | Bone marrow | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": 79.64650900338474, "identifiers": [{"i": "CL:0000501", "l": "granulosa cell", "d": ["A supporting cell for the developing female gamete in the ovary of mammals. They develop from the coelomic epithelial cells of the gonadal ridge. Granulosa cells form a single layer around the mammalian oocyte in the primordial ovarian follicle and advance to form a multilayered cumulus oophorus surrounding the ovum in the Graafian follicle. The major functions of granulosa cells include the production of steroids and LH receptors."], "t": []}], "preferred_name": "granulosa cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4072756", "l": "Cells.RARA gene rearrangements", "d": [], "t": []}], "preferred_name": "Cells.RARA gene rearrangements", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0000421", "l": "coelomocyte", "d": ["A free floating cell, including amebocytes and eleocytes, in the coelom of certain animals, especially annelids."], "t": []}], "preferred_name": "coelomocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 90.871710685482, "identifiers": [{"i": "CL:0001047", "l": "CD4-positive, CD25-positive, CCR4-positive, alpha-beta regulatory T cell", "d": ["A CD4-positive, CD25-positive, alpha-beta regulatory T cell with the additional phenotype CCR4-positive."], "t": []}], "preferred_name": "CD4-positive, CD25-positive, CCR4-positive, alpha-beta regulatory T cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0009111", "l": "centrocyte", "d": ["A germinal center B cell found in a lymph node germinal center light zone."], "t": []}], "preferred_name": "centrocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C4330725", "l": "Myelodysplastic Syndrome Clone", "d": [], "t": []}, {"i": "NCIT:C130199", "l": "Myelodysplastic Syndrome Clone", "d": ["A clonal population of dysplastic hematopoietic cells found in a patient with myelodysplastic syndrome."], "t": []}], "preferred_name": "Myelodysplastic Syndrome Clone", "taxa": []}
{"type": "biolink:Cell", "ic": 81.34422831136257, "identifiers": [{"i": "UMLS:C0025171", "l": "Megaloblasts", "d": [], "t": []}, {"i": "NCIT:C12524", "l": "Megaloblast", "d": [], "t": []}, {"i": "MESH:D008534", "l": "Megaloblasts", "d": [], "t": []}], "preferred_name": "Megaloblasts", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5427435", "l": "Xanthoma cells | Lower respiratory specimen | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Xanthoma cells | Lower respiratory specimen | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5443442", "l": "lisocabtagene maraleucel, CD8 component, 1 of 2", "d": [], "t": []}], "preferred_name": "lisocabtagene maraleucel, CD8 component, 1 of 2", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0002157", "l": "endosteal cell", "d": ["A cell type that makes up the highly vascular membrane lining the marrow cavity of long bones."], "t": []}, {"i": "UMLS:C1516866", "l": "Endosteal cell", "d": [], "t": []}, {"i": "NCIT:C32521", "l": "Endosteal Cell", "d": ["A cell lining the medullary cavity of bone."], "t": []}], "preferred_name": "endosteal cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5175602", "l": "Other cells | Blood | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Other cells | Blood | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C3827096", "l": "Anti-CD19-CAR-CD3zeta-4-1BB-Expressing Allogenic Natural Killer Cells", "d": [], "t": []}], "preferred_name": "Anti-CD19-CAR-CD3zeta-4-1BB-Expressing Allogenic Natural Killer Cells", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5186934", "l": "Platelets | Fetus | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Platelets | Fetus | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0009080", "l": "tuft cell of small intestine", "d": ["A tuft cell located in the small intestine."], "t": []}], "preferred_name": "tuft cell of small intestine", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4047025", "l": "type G cell of stomach", "d": ["Any type G enteroendocrine cell that is part of some epithelium of stomach."], "t": []}], "preferred_name": "type G cell of stomach", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5854445", "l": "Autologous Anti-CD1a CAR T Cells OC-1", "d": [], "t": []}, {"i": "NCIT:C199631", "l": "Autologous Anti-CD1a CAR T Cells OC-1", "d": ["A preparation of autologous T-lymphocytes that have been transduced with a lentiviral vector expressing a chimeric antigen receptor (CAR) specific for the T-cell surface glycoprotein CD1a, with potential immunostimulating and antineoplastic activities. Upon administration, autologous anti-CD1a CAR T cells OC-1 bind to and induce selective toxicity in CD1a-expressing tumor cells. CD1a, an antigen-presenting glycoprotein, is exclusively expressed in cortical T-cell acute lymphoblastic leukemia (T-ALL) and otherwise only normally expressed in developing cortical thymocytes and Langerhans cells."], "t": []}], "preferred_name": "Autologous Anti-CD1a CAR T Cells OC-1", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4510902", "l": "Blast cell positive for CD11a antigen", "d": [], "t": []}, {"i": "SNOMEDCT:724244001", "l": "", "d": [], "t": []}], "preferred_name": "Blast cell positive for CD11a antigen", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C2326743", "l": "Glycinergic amacrine cell of retina", "d": [], "t": []}], "preferred_name": "Glycinergic amacrine cell of retina", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1257751", "l": "Erythroid Cells", "d": [], "t": []}, {"i": "MESH:D041905", "l": "Erythroid Cells", "d": [], "t": []}, {"i": "SNOMEDCT:414128005", "l": "", "d": [], "t": []}], "preferred_name": "Erythroid Cells", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C3891660", "l": "Tumor-Associated Macrophage", "d": [], "t": []}, {"i": "NCIT:C116387", "l": "Tumor-Associated Macrophage", "d": ["Non-neoplastic macrophages that are found in close proximity to or within a tumor mass."], "t": []}, {"i": "MESH:D000084582", "l": "Tumor-Associated Macrophages", "d": [], "t": []}], "preferred_name": "Tumor-Associated Macrophage", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5447417", "l": "Tumor-Infiltrating Follicular Helper T Cell", "d": [], "t": []}, {"i": "NCIT:C176756", "l": "Tumor-Infiltrating Follicular Helper T Cell", "d": ["A follicular helper T cell that has migrated into a tumor."], "t": []}], "preferred_name": "Tumor-Infiltrating Follicular Helper T Cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5157519", "l": "CD3-CD16+CD56+ (Natural killer) cells | Blood | Cell markers", "d": [], "t": []}], "preferred_name": "CD3-CD16+CD56+ (Natural killer) cells | Blood | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C2919569", "l": "Colony-forming unit of granulocytic-macrophagocytic lineage (cell)", "d": [], "t": []}, {"i": "SNOMEDCT:444994007", "l": "", "d": [], "t": []}], "preferred_name": "Colony-forming unit of granulocytic-macrophagocytic lineage (cell)", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5401424", "l": "Innate Lymphoid Cell", "d": [], "t": []}, {"i": "NCIT:C171057", "l": "Innate Lymphoid Cell", "d": ["Innate immune cells in the lymphoid lineage that do not express recombination-activating genes (RAGs), T-cell or B-cell receptors, or any myeloid or dendritic cell markers. There are several subtypes of innate lymphoid cells (ILC): group 1 ILC express TBX21 and Th1 cytokines, group 2 ILC produce type 2 cytokines, group 3 ILC produce interleukin-17A (IL-17A) and/or IL-22 and lymphoid tissue inducer cells (LTi cells) do not express CD3 but do express IL-7, CD45, CD4 and a large number of additional markers."], "t": []}], "preferred_name": "Innate Lymphoid Cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1267824", "l": "T lymphocyte positive for both CD4 antigen and CD45RA antigen", "d": [], "t": []}, {"i": "SNOMEDCT:115403000", "l": "", "d": [], "t": []}], "preferred_name": "T lymphocyte positive for both CD4 antigen and CD45RA antigen", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1183428", "l": "Solocyte", "d": [], "t": []}], "preferred_name": "Solocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 85.53200374075534, "identifiers": [{"i": "CL:0000520", "l": "prokaryotic cell", "d": [], "t": []}, {"i": "UMLS:C0686817", "l": "Prokaryote", "d": [], "t": []}], "preferred_name": "prokaryotic cell", "taxa": []}
{"type": "biolink:Cell", "ic": 78.29800561113302, "identifiers": [{"i": "UMLS:C1518309", "l": "Neutrophil with Abnormal Cytoplasmic Granulation", "d": [], "t": []}, {"i": "NCIT:C37173", "l": "Neutrophil with Abnormal Cytoplasmic Granulation", "d": [], "t": []}], "preferred_name": "Neutrophil with Abnormal Cytoplasmic Granulation", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C0521184", "l": "Atypical squamous cells of uncertain significance", "d": [], "t": []}, {"i": "NCIT:C8434", "l": "Atypical Squamous Cell of Undetermined Significance", "d": [], "t": []}, {"i": "SNOMEDCT:39035006", "l": "", "d": [], "t": []}], "preferred_name": "Atypical squamous cells of uncertain significance", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "CL:0002671", "l": "endothelial stalk cell", "d": ["An endothelial stalk cell is a specialized endothelial cell that follows behind the tip cell of an angiogenic sprout."], "t": []}], "preferred_name": "endothelial stalk cell", "taxa": []}
{"type": "biolink:Cell", "ic": 84.83823963392128, "identifiers": [{"i": "CL:1000191", "l": "pillar cell", "d": ["A rod-like cell in the inner ear, having their heads joined and their bases on the basilar membrane widely separated so as to form a spiral tunnel known as the tunnel of Corti."], "t": []}, {"i": "UMLS:C0229470", "l": "Pillar cell", "d": [], "t": []}, {"i": "NCIT:C33322", "l": "Pillar Cell", "d": ["A flattened cell that rests on the tympanic lip of the spiral lamina (inner pillar cell) and on the basilar membrane (outer pillar cell), thereby forming the tunnel of the Organ of Corti."], "t": []}, {"i": "SNOMEDCT:55842008", "l": "", "d": [], "t": []}], "preferred_name": "pillar cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C2338585", "l": "Set of cholinergic cells of basal nucleus [Ch4]", "d": [], "t": []}], "preferred_name": "Set of cholinergic cells of basal nucleus [Ch4]", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0882849", "l": "CD34+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:116826008", "l": "", "d": [], "t": []}], "preferred_name": "CD34+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C2953996", "l": "Endothelial cell of endocardium of left ventricle", "d": [], "t": []}], "preferred_name": "Endothelial cell of endocardium of left ventricle", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1267997", "l": "Lymphocyte positive for CD118 antigen", "d": [], "t": []}, {"i": "SNOMEDCT:117437009", "l": "", "d": [], "t": []}], "preferred_name": "Lymphocyte positive for CD118 antigen", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5157448", "l": "CD3+CD56+ cells | Blood | Cell markers", "d": [], "t": []}], "preferred_name": "CD3+CD56+ cells | Blood | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": 90.871710685482, "identifiers": [{"i": "UMLS:C1512638", "l": "Immature Peripheral Gamma/Delta Cell of Cytotoxic Type", "d": [], "t": []}, {"i": "NCIT:C38326", "l": "Immature Peripheral Gamma/Delta Cell of Cytotoxic Type", "d": ["A cell derived from stem cells in the bone marrow. It is a maturing T lymphocyte that expresses a gamma-delta antigen specific surface receptor (TCR). These cells exert major histocompatibility-unrestricted natural cytotoxicity against several types of solid tumors and some leukemias and lymphomas. They are also involved in the immune response to certain infections and are able to mediate antibody-dependent cytotoxicity and are not alloreactive."], "t": []}], "preferred_name": "Immature Peripheral Gamma/Delta Cell of Cytotoxic Type", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5986173", "l": "19CP 02", "d": [], "t": []}], "preferred_name": "19CP 02", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0002680", "l": "PP cell of intestine", "d": ["A PP cell found in intestine."], "t": []}], "preferred_name": "PP cell of intestine", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1182627", "l": "Epithelial cell of gingival part of viscerocranial mucosa", "d": [], "t": []}], "preferred_name": "Epithelial cell of gingival part of viscerocranial mucosa", "taxa": []}
{"type": "biolink:Cell", "ic": 89.40238429118027, "identifiers": [{"i": "CL:0002634", "l": "epithelial cell of anal column", "d": ["An epithelial cell of the anal column."], "t": []}], "preferred_name": "epithelial cell of anal column", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:1000720", "l": "kidney papillary duct intercalated cell", "d": ["Any renal intercalated cell that is part of some papillary duct."], "t": []}], "preferred_name": "kidney papillary duct intercalated cell", "taxa": []}
{"type": "biolink:Cell", "ic": 87.18682603146104, "identifiers": [{"i": "CL:0000881", "l": "perivascular macrophage", "d": ["A border associated macrophage that is adjacent to a small blood vessel of a brain. A perivascular macrophage expresses the markers CD14, CD16 and CD163. In homeostatic conditions, this central nervous system macrophage has a non-motile cell body with extending and retracting projections through the blood vessel wall."], "t": []}], "preferred_name": "perivascular macrophage", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "CL:1000681", "l": "kidney cortex interstitial cell", "d": ["A cell that is part of an interstitial compartment of a renal cortex."], "t": []}], "preferred_name": "kidney cortex interstitial cell", "taxa": []}
{"type": "biolink:Cell", "ic": 88.20185721311867, "identifiers": [{"i": "CL:0000026", "l": "invertebrate nurse cell", "d": ["A germline cell that contributes to the development of the oocyte by transferring cytoplasm directly to oocyte."], "t": []}], "preferred_name": "invertebrate nurse cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1514658", "l": "RL15", "d": [], "t": []}, {"i": "NCIT:C20292", "l": "RL15", "d": ["Provider: Reliance Life Sciences, Mumbai, India. No information from provider. This cell line meets the criteria for the use of human embryonic stem cells by federally funded researchers."], "t": []}], "preferred_name": "RL15", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1510960", "l": "Atypical Metaplastic Apocrine Cell", "d": [], "t": []}, {"i": "NCIT:C36909", "l": "Atypical Metaplastic Apocrine Cell", "d": [], "t": []}], "preferred_name": "Atypical Metaplastic Apocrine Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C4086004", "l": "Autologous Colorectal Tumor Antigen-pulsed Dendritic Cell Vaccine", "d": [], "t": []}, {"i": "NCIT:C123918", "l": "Autologous Colorectal Tumor Antigen-pulsed Dendritic Cell Vaccine", "d": ["A dendritic cell (DC)-based cancer vaccine composed of autologous DCs pulsed with tumor cell lysates from a colorectal cancer patient containing tumor-associated antigens (TAAs), with potential immunostimulatory and antineoplastic activities. Upon administration, autologous colorectal tumor antigen-pulsed DC vaccine exposes the immune system to colorectal tumor cell antigens, which may result in cytotoxic T-lymphocyte (CTL)-mediated immune responses against the colorectal cancer cells. This leads to cancer cell lysis. The tumor cell lysate contains a range of antigens that are essential for the neoplastic growth and survival of the cancer cells."], "t": []}], "preferred_name": "Autologous Colorectal Tumor Antigen-pulsed Dendritic Cell Vaccine", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0230977", "l": "Desquamated fetal cells", "d": [], "t": []}, {"i": "SNOMEDCT:67709004", "l": "", "d": [], "t": []}], "preferred_name": "Desquamated fetal cells", "taxa": []}
{"type": "biolink:Cell", "ic": 80.27409497666227, "identifiers": [{"i": "CL:0002665", "l": "otic fibrocyte", "d": ["A mesenchymal cell within the inner ear, specifically localised to supportive connective tissues such as the spiral ligament and spiral limbus. This cell has specialised structural and molecular adaptations, and it contributes to the homeostasis of the cochlear environment by participating in ionic regulation crucial for auditory function."], "t": []}], "preferred_name": "otic fibrocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 36.097957061436304, "identifiers": [{"i": "CL:0001061", "l": "abnormal cell", "d": ["A cell found in an organism or derived from an organism exhibiting a phenotype that deviates from the expected phenotype of any native cell type of that organism. Abnormal cells are typically found in disease states or disease models."], "t": []}, {"i": "UMLS:C0333717", "l": "Abnormal cell", "d": [], "t": []}, {"i": "NCIT:C12913", "l": "Abnormal Cell", "d": ["An abnormal human cell type which can occur in either disease states or disease models."], "t": []}, {"i": "SNOMEDCT:39266006", "l": "", "d": [], "t": []}], "preferred_name": "abnormal cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0000536", "l": "secondary motor neuron (sensu Teleostei)", "d": ["A secondary neuron (sensu Teleostei) that has a motor function."], "t": []}, {"i": "UMLS:C2336440", "l": "Secondary motor neuron", "d": [], "t": []}], "preferred_name": "secondary motor neuron (sensu Teleostei)", "taxa": []}
{"type": "biolink:Cell", "ic": 81.34422831136257, "identifiers": [{"i": "UMLS:C1514186", "l": "Pluripotent Bone Marrow Stem Cell", "d": [], "t": []}, {"i": "NCIT:C33331", "l": "Pluripotent Bone Marrow Stem Cell", "d": ["A bone marrow stem cell able to differentiate into any given cell type."], "t": []}], "preferred_name": "Pluripotent Bone Marrow Stem Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C2827682", "l": "Autologous TGFbeta-Resistant HER2/EBV-Specific Cytotoxic T Lymphocytes", "d": [], "t": []}, {"i": "NCIT:C85459", "l": "Autologous TGFbeta-Resistant HER2/EBV-Specific Cytotoxic T Lymphocytes", "d": ["A preparation of transforming growth factor-beta (TGF-beta)-resistant Epstein-Barr virus (EBV)-specific cytotoxic T-lymphocytes (CTLs) directed to EBV through their native receptor and HER2 through a retrovirally transduced HER2 chimeric antigen receptor (CAR) with potential antineoplastic activity. Autologous EBV-specific CTLs are produced by exposing autologous CTLs to \"stimulator\" autologous EBV-transformed lymphoblastoid cell lines (EBV-LCLs). Subsequently, autologous EBV-specific CTLs are transduced with retroviral vectors expressing the mutant type II TGF-beta dominant-negative receptor (DNR), which blocks signaling by all three TGF-beta isoforms, and the HER2 CAR. After transduction, transgenic EBV-CTLs are expanded on EBV-LCLs. Upon administration, autologous HER2 chimeric receptor/TGFbeta dominant negative receptor-expressing EBV-specific cytotoxic T lymphocytes may bind to HER2-expressing tumors cells, which may result in CTL-mediated cell lysis and inhibition of tumor cell proliferation. Tumor-expressed TGF-beta inhibits T lymphocyte activation and expansion."], "t": []}], "preferred_name": "Autologous TGFbeta-Resistant HER2/EBV-Specific Cytotoxic T Lymphocytes", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5237046", "l": "Anti-TRBC1-CAR-CD3zeta-4-1BB-RQR8-expressing Autologous T-lymphocyte Cells AUTO4", "d": [], "t": []}, {"i": "NCIT:C165274", "l": "Anti-TRBC1-CAR-CD3zeta-4-1BB-RQR8-expressing Autologous T-lymphocyte Cells AUTO4", "d": ["Autologous human T-lymphocytes that are genetically engineered to express a chimeric antigen receptor (CAR) containing an anti-T-cell receptor beta constant 1 (TRBC1; T-cell receptor beta-1 chain C region) single chain variable fragment (scFv) and the co-stimulatory domain 4-1BB (CD137) coupled to the zeta chain of the TCR/CD3 complex (CD3-zeta), with potential immunostimulating and antineoplastic activities. Upon administration, anti-TRBC1-CAR-CD3zeta-4-1BB-RQR8-expressing autologous T-lymphocyte cells AUTO4 targets and binds to the TRBC1 expressed on tumor cell surfaces. Subsequently, TRBC1-expressing tumor cells are lysed. In addition, AUTO4 carries the universal RQR8 safety \"off\" switch, which allows selective removal of the T-cells through both complement-dependent cytotoxicity (CDC) and antibody-dependent cellular cytotoxicity (ADCC) following administration of rituximab if unacceptable side-effects occur."], "t": []}], "preferred_name": "Anti-TRBC1-CAR-CD3zeta-4-1BB-RQR8-expressing Autologous T-lymphocyte Cells AUTO4", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0020019", "l": "regulatory chondrocyte", "d": ["A chondrocyte located mainly in the superficial zone of articular cartilage. In healthy human cartilage, regulatory chondrocytes are characterized by expression of EIF5A, PGK1, ANXA1, and TUBA1A. During osteoarthritis, a distinct subpopulation expands, marked by high expression of CHI3L1, CHI3L2, CRTAC1, and AEBP1, with enrichment for signaling pathway regulation (including Toll-like receptor, mTOR, and TGF-beta signaling) and antigen-processing gene expression, with a small proportion expressing MHC class II genes, suggesting potential immune cell-like regulatory functions during osteoarthritis progression."], "t": []}], "preferred_name": "regulatory chondrocyte", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5827072", "l": "EB 101", "d": [], "t": []}], "preferred_name": "EB 101", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4030017", "l": "epithelial cell of late distal convoluted tubule", "d": ["An epithelial cell located in the late distal convoluted tubule."], "t": []}], "preferred_name": "epithelial cell of late distal convoluted tubule", "taxa": []}
{"type": "biolink:Cell", "ic": 83.11065783093733, "identifiers": [{"i": "CL:4033066", "l": "pre-granulosa cell", "d": ["A supporting cell that is part of the ovary and differentiates into a granulosa cell. A pre-granulosa cell develops from an early supporting gonadal cell by repressing testis determination, which can then proliferate to form primordial follicles."], "t": []}], "preferred_name": "pre-granulosa cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1267799", "l": "CYCD3+ lymphocyte", "d": [], "t": []}, {"i": "SNOMEDCT:117503003", "l": "", "d": [], "t": []}], "preferred_name": "CYCD3+ lymphocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5855298", "l": "Tinocabtagene Autoleucel", "d": [], "t": []}, {"i": "NCIT:C199018", "l": "Tinocabtagene Autoleucel", "d": [], "t": []}], "preferred_name": "Tinocabtagene Autoleucel", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4696636", "l": "CD4+CD25+CD45RA+CD127low cell", "d": [], "t": []}, {"i": "SNOMEDCT:1376033002", "l": "", "d": [], "t": []}], "preferred_name": "CD4+CD25+CD45RA+CD127low cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5983493", "l": "Elzocabtagene Autoleucel", "d": [], "t": []}, {"i": "NCIT:C211708", "l": "Elzocabtagene Autoleucel", "d": [], "t": []}], "preferred_name": "Elzocabtagene Autoleucel", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5854385", "l": "Autologous Gene-modified PD-1-positive T-lymphocytes Sc610", "d": [], "t": []}, {"i": "NCIT:C198984", "l": "Autologous Gene-modified PD-1-positive T-lymphocytes Sc610", "d": ["A preparation of autologous programmed cell death protein 1 (PD-1; PDCD1; CD279)-positive T-lymphocytes transduced with a lentiviral vector encoding for an as of yet undisclosed receptor, with potential immunostimulatory and antineoplastic activities. Upon administration, autologous gene-modified PD-1-positive T-lymphocytes Sc610 bind to tumor cells expressing the antigen for the as of yet undisclosed receptor, which may result in specific cytotoxic T-lymphocyte (CTL)-mediated tumor cell killing."], "t": []}], "preferred_name": "Autologous Gene-modified PD-1-positive T-lymphocytes Sc610", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4047054", "l": "migratory dendritic cell", "d": ["A dendritic cell capable of capturing antigens in peripheral tissues and migrating through blood or lymphatic vessels to secondary lymphoid organs, where it presents processed antigens to T cells. It expresses MHC class II molecules and lacks lineage markers associated with other leukocyte populations, distinguishing it as a member of the dendritic cell lineage. This cell plays a pivotal role in initiating and regulating adaptive immune responses by linking peripheral antigen capture with T cell activation in lymphoid tissues."], "t": []}], "preferred_name": "migratory dendritic cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4322827", "l": "CD22+CD19+ B lymphocyte", "d": [], "t": []}], "preferred_name": "CD22+CD19+ B lymphocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "CL:1000073", "l": "spinal cord radial glial cell", "d": ["Any radial glial cell that is part of some spinal cord."], "t": []}], "preferred_name": "spinal cord radial glial cell", "taxa": []}
{"type": "biolink:Cell", "ic": 68.05098739918701, "identifiers": [{"i": "UMLS:C1514934", "l": "Rhabdomyoblast", "d": [], "t": []}, {"i": "NCIT:C36744", "l": "Rhabdomyoblast", "d": ["A mesenchymal cell showing variable degrees of skeletal muscle differentiation. It is a polygonal, fusiform, round, or bizarre cell with a usually eccentric nucleus and bright eosinophilic cytoplasm sometimes exhibiting cross-striations."], "t": []}], "preferred_name": "Rhabdomyoblast", "taxa": []}
{"type": "biolink:Cell", "ic": 84.21065366064373, "identifiers": [{"i": "UMLS:C5706884", "l": "TPIT-Lineage Adenohypophysial Cell", "d": [], "t": []}, {"i": "NCIT:C187079", "l": "TPIT-Lineage Adenohypophysial Cell", "d": ["An adenohypophysial cell determined by the expression of T-box transcription factor TPIT."], "t": []}], "preferred_name": "TPIT-Lineage Adenohypophysial Cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1148303", "l": "Basophils+Eosinophils+Monocytes", "d": [], "t": []}], "preferred_name": "Basophils+Eosinophils+Monocytes", "taxa": []}
{"type": "biolink:Cell", "ic": 92.76600187037766, "identifiers": [{"i": "CL:0020021", "l": "fibrochondrocyte progenitor cell", "d": ["A mesenchymal progenitor cell located in fibrocartilaginous tissues, along the fibrochondrocytic differentiation pathway that co-expresses both fibrochondrocyte markers (COL1A1, COL3A1) and mesenchymal stem cell markers (MCAM/CD146, MYLK) in humans. This cell serves as a progenitor for mature fibrochondrocytes and other meniscal cell types, with differentiation regulated by TGF-β signaling, focal adhesion, and extracellular matrix-receptor interaction pathways."], "t": []}], "preferred_name": "fibrochondrocyte progenitor cell", "taxa": []}
{"type": "biolink:Cell", "ic": 78.54651317367835, "identifiers": [{"i": "CL:4023055", "l": "corticothalamic VAL/VM projecting glutamatergic neuron of the primary motor cortex", "d": ["A corticothalamic-projecting glutamatergic neuron that is located in L6 and lower L5 of the primary motor cortex, with a pyramidal morphology and mostly untufted apical dendrites terminating in midcortical layers. CT VAL/VM (ventroanterior-ventrolateral complex/ventromedial nucleus) cells have a near tonic firing pattern and are distinguished from L6 IT neurons by a lower inter-spike interval adaptation index."], "t": []}], "preferred_name": "corticothalamic VAL/VM projecting glutamatergic neuron of the primary motor cortex", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0003008", "l": "G5 retinal ganglion cell", "d": ["A mono-stratified retinal ganglion cell that has a medium dendritic field and a medium dendritic arbor with post sympatic terminals in sublaminar layer S2."], "t": []}], "preferred_name": "G5 retinal ganglion cell", "taxa": []}
{"type": "biolink:Cell", "ic": 73.85694246010084, "identifiers": [{"i": "CL:0002369", "l": "fungal spore", "d": ["A differentiated form of a fungus produced during or as a result of an asexual or sexual reproductive process; usually a cell with a thick cell wall that stores and protects one or more nuclei. Spores may be produced in response to, and are characteristically resistant to, adverse environmental conditions."], "t": []}], "preferred_name": "fungal spore", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5706514", "l": "Autologous Anti-mesothelin T-cell Receptor Fusion Construct/PD-1:CD28 Switch Receptor-expressing T-cells TC-510", "d": [], "t": []}, {"i": "NCIT:C188805", "l": "Autologous Anti-mesothelin T-cell Receptor Fusion Construct/PD-1:CD28 Switch Receptor-expressing T-cells TC-510", "d": ["A preparation of autologous T-lymphocytes that have been genetically engineered to express a single-domain antibody that recognizes human tumor-associated antigen (TAA) mesothelin (MSLN), fused to the N-terminus of the CD3-epsilon T-cell receptor (TCR) subunit which, upon expression is incorporated into the endogenous TCR complex, and a PD-1:CD28 switch receptor composed of the extracellular ligand binding domain of the human inhibitory receptor programmed cell death protein 1 (PD-1; PDCD1) fused to the transmembrane and cytoplasmic co-stimulatory signaling domains of CD28, with potential immunomodulating and antineoplastic activities. Upon reintroduction into the patient, autologous anti-MSLN TCR fusion construct/PD-1:CD28 switch receptor-expressing T-cells TC-510 specifically target and bind to MSLN-expressing tumor cells. This leads to T-cell activation and T-cell mediated lysis of MSLN-expressing tumor cells. The switch receptor expressed by the engineered T-cells TC-510 targets and binds to the PD-1 ligands, programmed cell death ligand 1 (PD-L1) and 2 (PD-L2), expressed on tumor cells. The nature of the PD-1/CD28 switch receptor fusion protein prevents the normal PD1/PD-L1-mediated T-cell suppression and, instead, promotes signaling through the CD28 domain, which results in the stimulation of T-lymphocytes. This induces enhanced toxicity against tumor cells. Mesothelin, a cell surface glycoprotein involved in cell adhesion, is overexpressed in a variety of cancer cell types."], "t": []}], "preferred_name": "Autologous Anti-mesothelin T-cell Receptor Fusion Construct/PD-1:CD28 Switch Receptor-expressing T-cells TC-510", "taxa": []}
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{"type": "biolink:Cell", "ic": 84.21065366064373, "identifiers": [{"i": "CL:4300370", "l": "VLMC NN vascular leptomeningeal cell (Mmus)", "d": ["A vascular leptomeningeal cell of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Apod (Mmus), Slc6a13 (Mmus). Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Subclass:330 VLMC NN."], "t": []}], "preferred_name": "VLMC NN vascular leptomeningeal cell (Mmus)", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0000117", "l": "CNS neuron (sensu Vertebrata)", "d": [], "t": []}], "preferred_name": "CNS neuron (sensu Vertebrata)", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5184821", "l": "Variant lymphocytes | Fetus | Blood | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Variant lymphocytes | Fetus | Blood | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:1000419", "l": "myoepithelial cell of lactiferous duct", "d": ["A myoepithelial cell that is part of the lactiferous duct."], "t": []}], "preferred_name": "myoepithelial cell of lactiferous duct", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1441121", "l": "Purkinje cell cytoplasmic type 2", "d": [], "t": []}], "preferred_name": "Purkinje cell cytoplasmic type 2", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4023171", "l": "trigeminal motor neuron", "d": ["A trigeminal neuron that is responsible for motor functions such as biting and chewing."], "t": []}], "preferred_name": "trigeminal motor neuron", "taxa": []}
{"type": "biolink:Cell", "ic": 90.871710685482, "identifiers": [{"i": "UMLS:C1709171", "l": "Neoplastic Eosinophilic Precursor", "d": [], "t": []}, {"i": "NCIT:C43232", "l": "Neoplastic Eosinophilic Precursor", "d": [], "t": []}], "preferred_name": "Neoplastic Eosinophilic Precursor", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0011014", "l": "non-motile sperm cell", "d": ["A sperm cell that is not cabaple of motion (motility)."], "t": []}], "preferred_name": "non-motile sperm cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4511890", "l": "Population of all burr cells in portion of fluid", "d": [], "t": []}, {"i": "SNOMEDCT:726507002", "l": "", "d": [], "t": []}], "preferred_name": "Population of all burr cells in portion of fluid", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C2335910", "l": "Set of cholinergic cells of dorsal tegmental area [Ch6]", "d": [], "t": []}], "preferred_name": "Set of cholinergic cells of dorsal tegmental area [Ch6]", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0002359", "l": "placental hematopoietic stem cell", "d": ["A hematopoietic stem cell of the placenta. This cell type is first observed E10.5 This cell type may give rise to fetal liver hematopoietic stem cells."], "t": []}], "preferred_name": "placental hematopoietic stem cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0002457", "l": "epidermal Langerhans cell", "d": ["A Langerhans cell that is in the epidermis and is CD45-positive, MHCII-positive, and CD11b-positive."], "t": []}], "preferred_name": "epidermal Langerhans cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0002389", "l": "uninucleate arthroconidium", "d": ["An arthroconidium that has only one nucleus."], "t": []}], "preferred_name": "uninucleate arthroconidium", "taxa": []}
{"type": "biolink:Cell", "ic": 88.20185721311867, "identifiers": [{"i": "CL:1000271", "l": "lung multiciliated epithelial cell", "d": ["An epithelial cell that is part of the lung epithelium. This cell is characterised by the presence of cilia on its apical surface."], "t": []}], "preferred_name": "lung multiciliated epithelial cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C4553719", "l": "Autologous iC9-CARCD19 T Cells", "d": [], "t": []}, {"i": "NCIT:C146823", "l": "Autologous iCASP9-CD19-expressing T-Lymphocytes", "d": ["A preparation of autologous T-lymphocytes that are transduced with a retroviral vector encoding a chimeric antigen receptor (CAR) specific for the tumor-associated antigen (TAA) CD19 and the inducible suicide gene human caspase 9 (iCASP9 or iC9), that is linked to a drug binding domain, with potential immunomodulating and antineoplastic activities. The iCASP9 construct consists of the entire coding sequence for the human FK506-drug binding protein (FKBP12) with an F36V mutation (FKBP12-F36V) that is linked to the gene encoding iC9, which is a modified form of the CASP9 gene where the sequences encoding the endogenous caspase activation and recruitment domains have been deleted. Upon intravenous administration, autologous iCASP9-CD19-expressing T-lymphocytes (iC9-CAR19 T-cells) target and bind to CD19-expressing tumor cells, thereby selectively lysing these tumor cells. If the administered T-cells cause unacceptable side effects, the chemical homodimerizer AP1903, which binds to the FKBP12-F36V drug-binding domain, can be administered; this induces caspase 9 expression, and results in apoptosis of the administered iC9-CAR19 T-cells. The CD19 antigen is a B-cell specific cell surface antigen expressed in all B-cell lineage malignancies."], "t": []}], "preferred_name": "Autologous iC9-CARCD19 T Cells", "taxa": []}
{"type": "biolink:Cell", "ic": 73.15076615569336, "identifiers": [{"i": "UMLS:C1513987", "l": "Neoplastic Hobnail Cell", "d": [], "t": []}, {"i": "NCIT:C36758", "l": "Neoplastic Hobnail Cell", "d": [], "t": []}], "preferred_name": "Neoplastic Hobnail Cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5216288", "l": "Neutrophils.segmented|NCnc|Pt|Bld", "d": [], "t": []}], "preferred_name": "Neutrophils.segmented|NCnc|Pt|Bld", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C2952444", "l": "Mononuclear phagocyte", "d": [], "t": []}], "preferred_name": "Mononuclear phagocyte", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5170953", "l": "Leukocytes other | Fetus | Blood | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Leukocytes other | Fetus | Blood | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5967049", "l": "Aucatzyl", "d": [], "t": []}], "preferred_name": "Aucatzyl", "taxa": []}
{"type": "biolink:Cell", "ic": 76.78008365410358, "identifiers": [{"i": "CL:0002362", "l": "cerebellar granule cell precursor", "d": ["A cell located in the outermost proliferative zone of the external germinal layer that can differentiate into astroglial cells and granule cells. This cell type is glial fibrillary acidic protein-positive and HNK1-positive."], "t": []}], "preferred_name": "cerebellar granule cell precursor", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:1000367", "l": "transitional myocyte of posterior internodal tract", "d": ["A transitional myocyte that is part of the posterior internodal tract."], "t": []}, {"i": "UMLS:C2335688", "l": "Transitional myocyte of posterior internodal tract", "d": [], "t": []}], "preferred_name": "transitional myocyte of posterior internodal tract", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4300401", "l": "Cells.chromosome region 7q31", "d": [], "t": []}], "preferred_name": "Cells.chromosome region 7q31", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0011027", "l": "skeletal muscle fibroblast", "d": ["Any fibroblast that is part of skeletal muscle tissue."], "t": []}], "preferred_name": "skeletal muscle fibroblast", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1517643", "l": "KA43", "d": [], "t": []}, {"i": "NCIT:C20273", "l": "KA43", "d": ["Provider: Karolinska Institute, Stockholm, Sweden. No information from provider. This cell line meets the criteria for the use of human embryonic stem cells by federally funded researchers."], "t": []}], "preferred_name": "KA43", "taxa": []}
{"type": "biolink:Cell", "ic": 87.18682603146104, "identifiers": [{"i": "UMLS:C1708646", "l": "Malignant Large Histiocyte", "d": [], "t": []}, {"i": "NCIT:C43255", "l": "Malignant Large Histiocyte", "d": [], "t": []}], "preferred_name": "Malignant Large Histiocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 82.62268137420203, "identifiers": [{"i": "UMLS:C1709674", "l": "Primitive Mesenchymal Round to Oval Cell", "d": [], "t": []}, {"i": "NCIT:C48916", "l": "Primitive Mesenchymal Round to Oval Cell", "d": [], "t": []}], "preferred_name": "Primitive Mesenchymal Round to Oval Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4310123", "l": "striatal SST-CHODL GABAergic interneuron (Primate)", "d": ["A sst chodl GABAergic interneuron of the Primates brain. These cells are located in the striatum . Reference transcriptomic data for this type can be found in the dataset/taxonomy - HMBA Basal Ganglia Consensus Taxonomy in cell set Group:STR SST-CHODL GABA."], "t": []}], "preferred_name": "striatal SST-CHODL GABAergic interneuron (Primate)", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5177779", "l": "Polymorphonuclear cells | Cerebral spinal fluid | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Polymorphonuclear cells | Cerebral spinal fluid | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C4764236", "l": "Citrate Blood Cell Fraction", "d": [], "t": []}, {"i": "NCIT:C158461", "l": "Citrate Blood Cell Fraction", "d": ["The blood cells that are harvested from a cell collection tube containing sodium citrate."], "t": []}], "preferred_name": "Citrate Blood Cell Fraction", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5449009", "l": "Abecma", "d": [], "t": []}], "preferred_name": "Abecma", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:1000493", "l": "mesothelial cell of visceral pleura", "d": ["A mesothelial cell that is part of the visceral pleura."], "t": []}, {"i": "UMLS:C2335177", "l": "Mesothelial cell of visceral pleura", "d": [], "t": []}], "preferred_name": "mesothelial cell of visceral pleura", "taxa": []}
{"type": "biolink:Cell", "ic": 68.69918268150474, "identifiers": [{"i": "CL:0001067", "l": "group 1 innate lymphoid cell", "d": ["An innate lymphoid cell that is capable of producing the type 1 cytokine IFN-gamma, but not Th2 or Th17 cell-associated cytokines."], "t": []}], "preferred_name": "group 1 innate lymphoid cell", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "UMLS:C1517098", "l": "FSH Cells", "d": [], "t": []}, {"i": "NCIT:C32641", "l": "FSH Cell", "d": ["A basophilic cell of the anterior pituitary gland whose granules secrete follicle-stimulating hormone"], "t": []}], "preferred_name": "FSH Cells", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0002380", "l": "oospore", "d": ["An asexual spore formed by Oomycetes; formed upon fertilization of an oosphere."], "t": []}], "preferred_name": "oospore", "taxa": []}
{"type": "biolink:Cell", "ic": 77.82747199602274, "identifiers": [{"i": "UMLS:C1522076", "l": "Abnormal Monocyte", "d": [], "t": []}, {"i": "NCIT:C37040", "l": "Abnormal Monocyte", "d": [], "t": []}], "preferred_name": "Abnormal Monocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 92.76600187037766, "identifiers": [{"i": "CL:1001106", "l": "kidney loop of Henle thick ascending limb epithelial cell", "d": ["An epithelial cell that is part of some loop of Henle thick ascending limb. It is known in some mammalian species that this cell may express the Na+-K+-2Cl− cotransporter (NKCC2) apically."], "t": []}], "preferred_name": "kidney loop of Henle thick ascending limb epithelial cell", "taxa": []}
{"type": "biolink:Cell", "ic": 80.61184433509295, "identifiers": [{"i": "CL:0000323", "l": "lysozyme secreting cell", "d": [], "t": []}], "preferred_name": "lysozyme secreting cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5555580", "l": "CD19-targeted CAR T2 Cells", "d": [], "t": []}, {"i": "NCIT:C179281", "l": "CD19-targeted CAR T2 Cells", "d": ["A preparation of T-lymphocytes that have been genetically modified to express a chimeric antigen receptor (CAR) targeting the tumor-associated antigen (TAA) CD19, with potential immunostimulating and antineoplastic activities. Upon administration, CD19-targeted CAR T2 cells target and bind to CD19-expressing tumor cells, thereby inducing selective toxicity in CD19-expressing tumor cells. CD19 antigen is a B-cell specific cell surface antigen expressed in all B-cell lineage malignancies."], "t": []}], "preferred_name": "CD19-targeted CAR T2 Cells", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5163545", "l": "Epithelial cells | XXX | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Epithelial cells | XXX | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5706295", "l": "Orca-T", "d": [], "t": []}], "preferred_name": "Orca-T", "taxa": []}
{"type": "biolink:Cell", "ic": 70.37024337467663, "identifiers": [{"i": "UMLS:C1514116", "l": "Neoplastic Trophoblastic Cell", "d": [], "t": []}, {"i": "NCIT:C36803", "l": "Neoplastic Trophoblastic Cell", "d": [], "t": []}], "preferred_name": "Neoplastic Trophoblastic Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5237380", "l": "UCART22", "d": [], "t": []}, {"i": "NCIT:C165696", "l": "Allogeneic CD22-specific Universal CAR-expressing T-lymphocytes UCART22", "d": ["A preparation of allogeneic, off-the-shelf (OTS), universal transcription activator-like effector nuclease (TALEN)-engineered T-lymphocytes that have been genetically modified to express a chimeric antigen receptor (CAR) targeting the tumor-associated antigen (TAA) human CD22 with potential immunomodulating and antineoplastic activities. Upon transfusion, allogeneic CD22-specific universal CAR-expressing T-lymphocytes UCART22 express anti-CD22-CAR on their cell surfaces and bind to the CD22 antigen on tumor cell surfaces, resulting in lysis of CD22-expressing tumor cells. CD22, a cell surface glycoprotein, is expressed on mature B-cells and on most malignant B-cells."], "t": []}], "preferred_name": "UCART22", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4764273", "l": "Azercabtagene zapreleucel", "d": [], "t": []}], "preferred_name": "Azercabtagene zapreleucel", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1956120", "l": "Dermal Dendritic Cells", "d": [], "t": []}], "preferred_name": "Dermal Dendritic Cells", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1267908", "l": "Lymphocyte positive for both CD33 antigen and CD44 antigen", "d": [], "t": []}, {"i": "SNOMEDCT:117579000", "l": "", "d": [], "t": []}], "preferred_name": "Lymphocyte positive for both CD33 antigen and CD44 antigen", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5157338", "l": "CD179a blasts | XXX | Cell markers", "d": [], "t": []}], "preferred_name": "CD179a blasts | XXX | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5220613", "l": "Spermatozoa|Urine/Urine sed", "d": [], "t": []}], "preferred_name": "Spermatozoa|Urine/Urine sed", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C6056376", "l": "Autologous CD34+ enriched cell population that contains hematopoietic stem and progenitor cells transduced ex-vivo using a lentiviral vector encoding alpha-L-iduronidase gene", "d": [], "t": []}], "preferred_name": "Autologous CD34+ enriched cell population that contains hematopoietic stem and progenitor cells transduced ex-vivo using a lentiviral vector encoding alpha-L-iduronidase gene", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4052070", "l": "dual-feature fallopian tube progenitor cell", "d": ["A bipotent progenitor cell within the human fallopian tube epithelium, characterized by the concurrent expression of epithelial (e.g., EpCAM/CD326) and endothelial (e.g., PECAM1/CD31) markers at both the cell surface and transcript levels. This cell has the capacity to differentiate into ciliated and secretory epithelial cells, as well as potentially endothelial/stromal lineages. Positioned at the apex of lineage bifurcation, the cell exhibits stem-like and endothelial features, representing an intermediate developmental state between undifferentiated progenitors and lineage-committed epithelial cells."], "t": []}], "preferred_name": "dual-feature fallopian tube progenitor cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5216198", "l": "Cells|NCnc|Pt|Body fld", "d": [], "t": []}], "preferred_name": "Cells|NCnc|Pt|Body fld", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5157462", "l": "CD3+CD8+CD45RO+ cells | Blood | Cell markers", "d": [], "t": []}], "preferred_name": "CD3+CD8+CD45RO+ cells | Blood | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1511464", "l": "CY30", "d": [], "t": []}, {"i": "NCIT:C20238", "l": "CY30", "d": ["Provider: CyThera, Inc., San Diego, CA. No information from provider. This cell line meets the criteria for the use of human embryonic stem cells by federally funded researchers."], "t": []}], "preferred_name": "CY30", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5420910", "l": "Mipetresgene Autoleucel", "d": [], "t": []}, {"i": "NCIT:C174683", "l": "Mipetresgene Autoleucel", "d": [], "t": []}], "preferred_name": "Mipetresgene Autoleucel", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4033095", "l": "diffuse bipolar 4a cell", "d": ["An ON bipolar cell that has high expression of DIRC3, KCNJ3, LINC01915, PTPRK compared with other bipolar cells."], "t": []}], "preferred_name": "diffuse bipolar 4a cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0002446", "l": "Ly49CI-negative natural killer cell, mouse", "d": ["A NK1.1-positive T cell that is Ly49Cl-negative."], "t": []}], "preferred_name": "Ly49CI-negative natural killer cell, mouse", "taxa": []}
{"type": "biolink:Cell", "ic": 85.53200374075534, "identifiers": [{"i": "CL:0002033", "l": "short term hematopoietic stem cell", "d": ["A hematopoietic stem cell capable of rapid replenishment of myeloerythroid progenitors and limited self renewal capability. This cell is Kit-positive, Sca1-positive, CD34-positive, CD150-positive, and is Flt3-negative."], "t": []}], "preferred_name": "short term hematopoietic stem cell", "taxa": []}
{"type": "biolink:Cell", "ic": 89.40238429118027, "identifiers": [{"i": "CL:0000964", "l": "Bm2' B cell", "d": ["A germinal center B cell that founds a germinal center, and has the phenotype IgD-positive, CD38-positive, and CD23-negative."], "t": []}], "preferred_name": "Bm2' B cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C2347433", "l": "Adipose-Derived Regenerative Cells", "d": [], "t": []}, {"i": "NCIT:C73997", "l": "Adipose-Derived Regenerative Cells", "d": ["A population of cells derived from adipose tissue with stem cell and wound repair activities. Adipose-derived regenerative cells (ADRC) consists of several cell types, such as adult stem cells, vascular endothelial cells, and vascular smooth muscle cells, among others. These cells contribute to wound repair through a variety of mechanisms by promoting blood vessel growth and blocking apoptosis. In addition, ADRC can differentiate into several tissue types, such as bone, cartilage, fat, skeletal muscle, smooth muscle and cardiac muscle."], "t": []}], "preferred_name": "Adipose-Derived Regenerative Cells", "taxa": []}
{"type": "biolink:Cell", "ic": 82.16838616155795, "identifiers": [{"i": "UMLS:C1520127", "l": "Warthin-Finkeldey Polykaryocyte", "d": [], "t": []}, {"i": "NCIT:C36812", "l": "Warthin-Finkeldey Polykaryocyte", "d": [], "t": []}], "preferred_name": "Warthin-Finkeldey Polykaryocyte", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C2736928", "l": "CD154+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:732273005", "l": "", "d": [], "t": []}], "preferred_name": "CD154+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": 88.20185721311867, "identifiers": [{"i": "CL:0000189", "l": "slow muscle cell", "d": ["A muscle cell that develops tension more slowly than a fast-twitch fiber."], "t": []}], "preferred_name": "slow muscle cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:1000276", "l": "smooth muscle fiber of duodenum", "d": ["A smooth muscle cell that is part of the duodenum."], "t": []}, {"i": "UMLS:C0734267", "l": "Smooth muscle fiber of duodenum", "d": [], "t": []}], "preferred_name": "smooth muscle fiber of duodenum", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C3640949", "l": "Inducible CD4+CD25+ Regulatory T Cells", "d": [], "t": []}, {"i": "NCIT:C102789", "l": "Inducible CD4+CD25+ Regulatory T Cells", "d": ["Inducible regulatory T-lymphocytes that express CD4, CD25 (the alpha chain of the interleukin 2 receptor) and forkhead box P3 (FOXP3), with potential immunomodulating activity. Inducible CD4+CD25+ T regulatory cells (iTregs) are a subset of CD4+ T lymphocytes that are induced from CD25- precursors in peripheral lymphoid organs with interleukin-2 and transforming growth factor-beta. These regulatory T cells are essential in maintaining immunologic homeostasis. They may also prevent autoimmunity by suppressing self-reactive T cells, and may induce tolerance to allogeneic organ transplants such as in hematopoietic stem cell transplants."], "t": []}], "preferred_name": "Inducible CD4+CD25+ Regulatory T Cells", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0020023", "l": "effector chondrocyte", "d": ["A metabolically highly active chondrocyte that is identified in the cartilaginous tissues, including articular cartilage and intervertebral disc cartilage. In the human articular cartilage, this cell is marked by genes such as CYTL1, FRZB, CLEC3A, and S100B (Ji et al., 2018; Raut et al.,2025). This cell demonstrates strong metabolic activity and is implicated in extracellular matrix regulation and adaptive responses (Ji et al., 2018; Gan et al., 2021; Raut et al.,2025)."], "t": []}], "preferred_name": "effector chondrocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0000621", "l": "fusion competent myoblast", "d": ["A myoblast that is committed to a myotube-specific program of differentiation but not yet fused. It undergoes very limited additional proliferation. After fusion, it will take on a muscle identity specified by a `muscle founder cell` (CL:0008006)."], "t": []}], "preferred_name": "fusion competent myoblast", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1148429", "l": "Unidentified cell", "d": [], "t": []}, {"i": "SNOMEDCT:115425006", "l": "", "d": [], "t": []}], "preferred_name": "Unidentified cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5184824", "l": "Variant lymphocytes | Synovial fluid | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Variant lymphocytes | Synovial fluid | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5763098", "l": "ALLOGENIC ADIPOSE DERIVED MESENCHYMAL STEM CELLS (MSCS) EXOSOMES", "d": [], "t": []}], "preferred_name": "ALLOGENIC ADIPOSE DERIVED MESENCHYMAL STEM CELLS (MSCS) EXOSOMES", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4241121", "l": "Rhombencephalic neural crest cell", "d": [], "t": []}], "preferred_name": "Rhombencephalic neural crest cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1267872", "l": "Lymphocyte positive for CD13 antigen", "d": [], "t": []}, {"i": "SNOMEDCT:117551006", "l": "", "d": [], "t": []}], "preferred_name": "Lymphocyte positive for CD13 antigen", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1276862", "l": "Entire endocervical glandular cell", "d": [], "t": []}, {"i": "SNOMEDCT:255065002", "l": "", "d": [], "t": []}], "preferred_name": "Entire endocervical glandular cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0521391", "l": "Central motor neuron", "d": [], "t": []}], "preferred_name": "Central motor neuron", "taxa": []}
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{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1519120", "l": "SA01", "d": [], "t": []}, {"i": "NCIT:C20264", "l": "SA01", "d": ["Provider: Goteborg University, Goteborg, Sweden. No information from provider. This cell line meets the criteria for the use of human embryonic stem cells by federally funded researchers."], "t": []}], "preferred_name": "SA01", "taxa": []}
{"type": "biolink:Cell", "ic": 82.62268137420203, "identifiers": [{"i": "CL:0004251", "l": "narrow field retinal amacrine cell", "d": ["An amicrine that has a narrow dendritic field."], "t": []}], "preferred_name": "narrow field retinal amacrine cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5157373", "l": "CD2 cells | XXX | Cell markers", "d": [], "t": []}], "preferred_name": "CD2 cells | XXX | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0333822", "l": "Microlymphoblast", "d": [], "t": []}, {"i": "SNOMEDCT:2014001", "l": "", "d": [], "t": []}], "preferred_name": "Microlymphoblast", "taxa": []}
{"type": "biolink:Cell", "ic": 42.82836156369674, "identifiers": [{"i": "UMLS:C1514104", "l": "Neoplastic Stromal Cell", "d": [], "t": []}, {"i": "NCIT:C37150", "l": "Neoplastic Stromal Cell", "d": [], "t": []}], "preferred_name": "Neoplastic Stromal Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5554957", "l": "Anti-CLDN6 CAR T-cells", "d": [], "t": []}, {"i": "NCIT:C178332", "l": "Anti-CLDN6 CAR T-cells", "d": ["A preparation of T-lymphocytes expressing a chimeric antigen receptor (CAR) targeting the cell surface protein claudin 6 (CLDN6), with potential immunostimulating and antineoplastic activities. Upon administration, the anti-CLDN6 CAR T-cells specifically target and bind to CLDN6-expressing tumor cells, thereby selectively lysing CLDN6-expressing tumor cells. CLDN-6, a transmembrane tight-junction protein and embryonic antigen, is overexpressed on a variety of tumor cells but is not expressed on normal, healthy adult cells."], "t": []}], "preferred_name": "Anti-CLDN6 CAR T-cells", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:1000433", "l": "epithelial cell of lacrimal canaliculus", "d": ["An epithelial cell that is part of the lacrimal canaliculus."], "t": []}, {"i": "UMLS:C1182612", "l": "Epithelial cell of lacrimal canaliculus", "d": [], "t": []}], "preferred_name": "epithelial cell of lacrimal canaliculus", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C3831510", "l": "Anti-VEGFR2-CAR Retroviral Vector-transduced Autologous T-lymphocytes", "d": [], "t": []}, {"i": "NCIT:C111038", "l": "Anti-VEGFR2-CAR Retroviral Vector-transduced Autologous T-lymphocytes", "d": ["Autologous human CD8-positive T-lymphocytes transduced with a recombinant retroviral vector encoding a chimeric T cell receptor (chimeric antigen receptor or CAR) consisting of an anti-vascular endothelial growth factor receptor type 2 (VEGFR2) scFv (single chain variable fragment), linked to the transmembrane domain of human CD8alpha and coupled to the costimulatory signaling domains of both CD28 and 4-1BB (CD137), and the CD3 zeta chain of the T-cell receptor (TCR), with potential immunostimulating and antineoplastic activities. Autologous peripheral blood lymphocytes (PBLs) from a patient with VEGFR2-positive cancer are pulsed with a retroviral vector that encodes the CAR gene specific for VEGFR2. After expansion in culture and reintroduction into the patient, the anti-VEGFR2 CAR-gene engineered CD8+ lymphocytes express anti-VEGFR2-CAR on their cell surfaces and bind to the VEGFR2 antigen on tumor cell surfaces. Subsequently, VEGFR2-expressing tumor cells are lysed. VEGFR2, a receptor tyrosine kinase (RTK) overexpressed by a variety of cancer cell types, belongs to the VEGFR superfamily and plays key roles in tumor cell proliferation, survival, invasion and tumor angiogenesis. The co-stimulatory molecules are required for optimal T-cell activation."], "t": []}], "preferred_name": "Anti-VEGFR2-CAR Retroviral Vector-transduced Autologous T-lymphocytes", "taxa": []}
{"type": "biolink:Cell", "ic": 76.5892103226413, "identifiers": [{"i": "CL:0000604", "l": "retinal rod cell", "d": ["One of the two photoreceptor cell types of the vertebrate retina. In rods the photopigment is in stacks of membranous disks separate from the outer cell membrane. Rods are more sensitive to light than cones, but rod mediated vision has less spatial and temporal resolution than cone vision."], "t": []}, {"i": "UMLS:C0206427", "l": "Rod Photoreceptors", "d": [], "t": []}, {"i": "NCIT:C12638", "l": "Retinal Rod", "d": ["A photoreceptor cell located in the retina of the eye that allows low light vision."], "t": []}, {"i": "MESH:D017948", "l": "Retinal Rod Photoreceptor Cells", "d": [], "t": []}, {"i": "SNOMEDCT:17139002", "l": "", "d": [], "t": []}], "preferred_name": "retinal rod cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1829707", "l": "CD19+ZAP70+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:1373157008", "l": "", "d": [], "t": []}], "preferred_name": "CD19+ZAP70+ cell", "taxa": []}
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{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4052040", "l": "tuft cell of stomach", "d": ["A tuft cell that is part of the epithelium of the stomach. This cell is characterized by gastric chemosensation and immune regulation through IL-25 secretion, which activates ILC2s to produce IL-13, driving epithelial remodelling and tuft cell expansion. Unlike intestinal tuft cells, which are primarily involved in helminth defense and type 2 immunity, the tuft cell of the stomach is primarily involved in inflammation, metaplasia, and hyperplasia."], "t": []}], "preferred_name": "tuft cell of stomach", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C2327049", "l": "Non-keratinized squamous cell", "d": [], "t": []}], "preferred_name": "Non-keratinized squamous cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1440329", "l": "CD50+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:1372904003", "l": "", "d": [], "t": []}], "preferred_name": "CD50+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": 77.82747199602274, "identifiers": [{"i": "CL:0012000", "l": "astrocyte of the forebrain", "d": ["An astrocyte of the forebrain."], "t": []}], "preferred_name": "astrocyte of the forebrain", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0884134", "l": "CD24+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:1372865000", "l": "", "d": [], "t": []}], "preferred_name": "CD24+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5186974", "l": "Reticulocytes | Fetus | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Reticulocytes | Fetus | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": 92.76600187037766, "identifiers": [{"i": "CL:0000396", "l": "lamellocyte", "d": ["A hemocyte found in immuno-stimulated larvae."], "t": []}], "preferred_name": "lamellocyte", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C6021988", "l": "Epithelial cells | Pus | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Epithelial cells | Pus | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": 82.16838616155795, "identifiers": [{"i": "UMLS:C1710694", "l": "Xanthomatous Cell", "d": [], "t": []}, {"i": "NCIT:C49071", "l": "Xanthomatous Cell", "d": [], "t": []}], "preferred_name": "Xanthomatous Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0002444", "l": "Ly49H-positive natural killer cell, mouse", "d": ["A NK1.1-positive T cell that is Ly49H-positive."], "t": []}], "preferred_name": "Ly49H-positive natural killer cell, mouse", "taxa": []}
{"type": "biolink:Cell", "ic": 70.51821968886674, "identifiers": [{"i": "UMLS:C1881590", "l": "Malignant Round Germ Cell with Glycogen-Rich Cytoplasm and Round Nucleus", "d": [], "t": []}, {"i": "NCIT:C61064", "l": "Malignant Round Germ Cell with Glycogen-Rich Cytoplasm and Round Nucleus", "d": [], "t": []}], "preferred_name": "Malignant Round Germ Cell with Glycogen-Rich Cytoplasm and Round Nucleus", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5157637", "l": "CD64 cells | Blood | Cell markers", "d": [], "t": []}], "preferred_name": "CD64 cells | Blood | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5420485", "l": "CD20-CD19 Compound CAR T Cells", "d": [], "t": []}, {"i": "NCIT:C173960", "l": "CD20-CD19 Compound CAR T Cells", "d": ["A preparation of T-lymphocytes transduced with a lentiviral vector expressing a compound chimeric antigen receptor (cCAR) containing two distinct units of CARs, one specific for the tumor-associated antigen (TAA) cluster of differentiation 20 (CD20) and one specific for the TAA CD19, with potential immunomodulating and antineoplastic activities. Upon administration, the CD20-CD19 cCAR T cells specifically and simultaneously target and bind to tumor cells expressing CD20 and/or CD19. This induces selective toxicity in tumor cells that express CD20 and/or CD19. Both CD19 and CD20 are B-cell-specific cell surface antigens overexpressed in B-cell lineage malignancies. Targeting two different antigens may improve coverage and protect against antigen escape and relapse as it is less likely for tumor cells to lose both antigens."], "t": []}], "preferred_name": "CD20-CD19 Compound CAR T Cells", "taxa": []}
{"type": "biolink:Cell", "ic": 75.876659701315, "identifiers": [{"i": "UMLS:C1513934", "l": "Neoplastic Blastemal Cell", "d": [], "t": []}, {"i": "NCIT:C37121", "l": "Neoplastic Blastemal Cell", "d": [], "t": []}], "preferred_name": "Neoplastic Blastemal Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4033111", "l": "middle cervical ganglion NPY neuron", "d": ["A sympathetic neuron that has the soma located in the middle cervical ganglion and expresses the marker neuropeptide Y (NPY)."], "t": []}], "preferred_name": "middle cervical ganglion NPY neuron", "taxa": []}
{"type": "biolink:Cell", "ic": 68.26004206441749, "identifiers": [{"i": "UMLS:C1514023", "l": "Neoplastic Meningothelial Cell", "d": [], "t": []}, {"i": "NCIT:C37155", "l": "Neoplastic Meningothelial Cell", "d": [], "t": []}], "preferred_name": "Neoplastic Meningothelial Cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5177621", "l": "Platelets | Fetus | Blood | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Platelets | Fetus | Blood | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5157422", "l": "CD3 blasts | XXX | Cell markers", "d": [], "t": []}], "preferred_name": "CD3 blasts | XXX | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C4763599", "l": "Autologous Anti-NY-ESO-1 mTCR Retroviral Vector Transduced PBLs", "d": [], "t": []}, {"i": "NCIT:C157409", "l": "Autologous Anti-NY-ESO-1 mTCR Retroviral Vector Transduced PBLs", "d": ["Human autologous peripheral blood lymphocytes (PBLs) transduced with a retroviral vector encoding both alpha and beta chains of a murine T-cell receptor (mTCR) specific for the cancer-testis antigen NY-ESO-1, with potential antineoplastic activity. Upon isolation, transduction, expansion ex vivo, and reintroduction into the patient, the autologous anti-NY-ESO-1 mTCR retroviral vector transduced PBLs bind to NY-ESO-1 expressed on tumor cells. This may result in cytotoxic T-lymphocyte (CTL)-mediated killing of NY-ESO-1-positive cancer cells. NY-ESO-1, a tumor-associated antigen (TAA), is found in normal testis and on the surface of various tumor cell types."], "t": []}], "preferred_name": "Autologous Anti-NY-ESO-1 mTCR Retroviral Vector Transduced PBLs", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C2338514", "l": "Set of Ch3 cholinergic cells", "d": [], "t": []}], "preferred_name": "Set of Ch3 cholinergic cells", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5959685", "l": "Autologous Anti-FcRL5 CAR-T Cells", "d": [], "t": []}, {"i": "NCIT:C206266", "l": "Autologous Anti-FcRL5 CAR-T Cells", "d": ["A preparation of autologous T-lymphocytes engineered to express a chimeric antigen receptor (CAR) targeting Fc receptor-like protein 5 (FcRL5; Fc receptor-homolog 5; FcRH5), with potential antineoplastic activity. Upon administration, autologous anti-FcRL5 CAR-T cells recognize and kill FcRL5-expressing tumor cells. FcRL5, an immune receptor translocation-associated protein/Fc receptor homolog (IRTA/FcRH) family member and a B-cell lineage marker, is overexpressed in multiple myeloma."], "t": []}], "preferred_name": "Autologous Anti-FcRL5 CAR-T Cells", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1519737", "l": "Tzanck Cell", "d": [], "t": []}, {"i": "NCIT:C39665", "l": "Tzanck Cell", "d": [], "t": []}], "preferred_name": "Tzanck Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5206608", "l": "Autologous BCMA-targeted CAR T Cells LCAR-B4822M", "d": [], "t": []}, {"i": "NCIT:C162506", "l": "Autologous BCMA-targeted CAR T Cells LCAR-B4822M", "d": ["A preparation of autologous peripheral blood T-lymphocytes (PBTLs) that have been genetically modified to express a chimeric antigen receptor (CAR) specific for the B-cell maturation antigen (BCMA; tumor necrosis factor receptor superfamily member 17; TNFRSF17), with potential immunostimulating and antineoplastic activities. Upon administration, autologous BCMA-targeted CAR T-cells LCAR-B4822M specifically recognize and kill BCMA-expressing tumor cells. BCMA, a tumor specific antigen and a receptor for both a proliferation-inducing ligand (APRIL) and B-cell activating factor (BAFF), is a member of the tumor necrosis factor (TNF) receptor superfamily and plays a key role in plasma cell survival; it is found on the surfaces of plasma cells and overexpressed on malignant plasma cells."], "t": []}], "preferred_name": "Autologous BCMA-targeted CAR T Cells LCAR-B4822M", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "UMLS:C1711269", "l": "Neoplastic Lactotroph Cell with Large Secretory Granules", "d": [], "t": []}, {"i": "NCIT:C45952", "l": "Neoplastic Lactotroph Cell with Large Secretory Granules", "d": [], "t": []}], "preferred_name": "Neoplastic Lactotroph Cell with Large Secretory Granules", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1517304", "l": "Foveolar cell", "d": [], "t": []}, {"i": "NCIT:C32632", "l": "Foveolar Cell", "d": ["An epithelial cell found in the glands of the gastric mucosa."], "t": []}], "preferred_name": "Foveolar cell", "taxa": []}
{"type": "biolink:Cell", "ic": 71.83956976897835, "identifiers": [{"i": "UMLS:C0227599", "l": "Transitional epithelial cell of urinary bladder", "d": [], "t": []}, {"i": "NCIT:C32210", "l": "Bladder Urothelial Cell", "d": ["An epithelial cell, found in the bladder, originally thought to represent a transitional form between stratified squamous and columnar epithelial cells.  In the contracted condition the epithelium consists of many cell layers, whereas in the stretched condition usually only two layers of cells can be distinguished."], "t": []}, {"i": "SNOMEDCT:2150006", "l": "", "d": [], "t": []}], "preferred_name": "Transitional epithelial cell of urinary bladder", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5237176", "l": "Autologous Tn-MUC1-specific CAR T-lymphocytes", "d": [], "t": []}, {"i": "NCIT:C165433", "l": "Autologous Tn-MUC1-specific CAR T-lymphocytes", "d": ["A preparation of autologous T-lymphocytes that have been genetically modified to express a chimeric antigen receptor (CAR) specific for the tumor-associated antigen (TAA) Tn glycoform of mucin-1 (Tn-MUC1; TnMUC1), with potential antineoplastic and immunostimulating activities. Upon re-introduction into the patient, the autologous Tn-MUC1-specific CAR T-lymphocytes specifically recognize and induce selective toxicity in TnMUC1-expressing tumor cells. TnMUC1 is overexpressed in certain tumor types."], "t": []}], "preferred_name": "Autologous Tn-MUC1-specific CAR T-lymphocytes", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4307113", "l": "ABC NN_1 Pde11a arachnoid barrier cell (Mmus)", "d": ["A arachnoid barrier cell of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Slc47a1 (Mmus), Pde11a (Mmus). It is distinguished from other ABC NN cells by expression of Pde11a. These cells are located in the brain . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5293 ABC NN_1."], "t": []}], "preferred_name": "ABC NN_1 Pde11a arachnoid barrier cell (Mmus)", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "UMLS:C1518173", "l": "Malignant Eosinophilic Cell Oncocyte", "d": [], "t": []}, {"i": "NCIT:C37167", "l": "Malignant Eosinophilic Cell Oncocyte", "d": [], "t": []}], "preferred_name": "Malignant Eosinophilic Cell Oncocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C3642265", "l": "Autologous CD19CAR-CD28-CD3zeta-EGFRt-expressing Tcm-enriched T Cells", "d": [], "t": []}, {"i": "NCIT:C105614", "l": "Autologous CD19CAR-CD28-CD3zeta-EGFRt-expressing Tcm-enriched T Cells", "d": ["A preparation of genetically modified autologous central memory (Tcm) enriched T-cells transduced with a replication incompetent lentiviral vector expressing a chimeric antigen receptor (CAR), containing a CD28 signaling domain fused to both CD3 zeta, which targets the CD19 antigen, and a truncated form of the human epidermal growth factor receptor (EGFRt), with potential immunostimulating and antineoplastic activities. Upon intravenous administration, autologous CD19CAR-CD28-CD3zeta-EGFRt-expressing Tcm-enriched T cells are directed to CD19-expressing tumor cells, thereby inducing a selective toxicity in CD19-expressing tumor cells. CD19 antigen is a B-cell specific cell surface antigen expressed in all B-cell lineage malignancies.  Devoid of both ligand binding domains and tyrosine kinase activity, EGFRt both facilitates in vivo detection of the administered T-cells and can promote elimination of those cells upon a cetuximab-induced antibody dependent cellular cytotoxicity response. The costimulatory signaling domain enhances proliferation of T cells and antitumor activity."], "t": []}], "preferred_name": "Autologous CD19CAR-CD28-CD3zeta-EGFRt-expressing Tcm-enriched T Cells", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4696700", "l": "CD19+CD27+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:1372979007", "l": "", "d": [], "t": []}], "preferred_name": "CD19+CD27+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1267812", "l": "Lymphoblast positive for CD2 antigen", "d": [], "t": []}, {"i": "SNOMEDCT:117515004", "l": "", "d": [], "t": []}], "preferred_name": "Lymphoblast positive for CD2 antigen", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "CL:0010015", "l": "coronet cell", "d": ["A highly specialized cell type exclusive to and forming neuroepithelium of the Saccus vasculosus, covering the caudal diverticulum of the infundibular recess."], "t": []}], "preferred_name": "coronet cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5856617", "l": "BCMA-TGF-beta Insensitive Armored CAR T Cells", "d": [], "t": []}, {"i": "NCIT:C201071", "l": "BCMA-TGF-beta Insensitive Armored CAR T Cells", "d": ["A preparation of human T-lymphocytes genetically engineered to express a chimeric antigen receptor (CAR) specific for the tumor-associated antigen (TAA) B-cell maturation antigen (BCMA; tumor necrosis factor receptor superfamily member 17; TNFRSF17) and armored to be insensitive to the immunosuppressive cytokine transforming growth factor-beta (TGF-beta), with potential immunostimulating and antineoplastic activities. Upon administration, BCMA-TGF-beta insensitive armored CAR T cells specifically recognize and induce selective toxicity in BCMA-expressing tumor cells. BCMA, a receptor for both a proliferation-inducing ligand (APRIL) and B-cell activating factor (BAFF), is a member of the tumor necrosis factor receptor superfamily (TNFRSF). BCMA, found on the surfaces of plasma cells and overexpressed on malignant plasma cells, plays a key role in plasma cell proliferation and survival. Though the nature of the TGF-beta armor has yet to be fully elucidated, it prevents the binding of TGF-beta to the CAR T-cells. TGF-beta negatively regulates T-cell proliferation and activation, contributes to the immunosuppressive nature of the tumor microenvironment (TME), and plays a key role in promoting tumor initiation, metastasis, and suppressing anti-tumor immunity."], "t": []}], "preferred_name": "BCMA-TGF-beta Insensitive Armored CAR T Cells", "taxa": []}
{"type": "biolink:Cell", "ic": 53.675085911982784, "identifiers": [{"i": "UMLS:C1513029", "l": "Mature T-Lymphocyte", "d": [], "t": []}, {"i": "NCIT:C33061", "l": "Mature T-Lymphocyte", "d": ["A lymphocyte derived from a pre T-lymphocyte in the thymus and stored in secondary lymphoid organs, bone marrow, and lymph nodes. It circulates in the bloodstream and the lymphatic system, where it searches for and attacks particular foreign or abnormal cells. A mature T lymphocyte has T cell receptors and other surface proteins on its cell surface."], "t": []}], "preferred_name": "Mature T-Lymphocyte", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5691290", "l": "Airway M Cells", "d": [], "t": []}], "preferred_name": "Airway M Cells", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C3890720", "l": "PC-3 cell line", "d": [], "t": []}, {"i": "NCIT:C117219", "l": "PC-3", "d": ["An adenocarcinoma cell line established in 1979 from a bone metastasis from a 62 year old Caucasian male patient with stage IV prostate carcinoma."], "t": []}, {"i": "MESH:D000078722", "l": "PC-3 Cells", "d": [], "t": []}], "preferred_name": "PC-3 cell line", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4023109", "l": "vasopressin-secreting magnocellular cell", "d": ["A magnocellular neurosecretory cell that is capable of producing and secreting vasopressin."], "t": []}], "preferred_name": "vasopressin-secreting magnocellular cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0545062", "l": "P.B. osteoblast", "d": [], "t": []}], "preferred_name": "P.B. osteoblast", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "CL:0000686", "l": "cerebrospinal fluid secreting cell", "d": ["A columnar/cuboidal epithelial cell that secretes cerebrospinal fluid."], "t": []}], "preferred_name": "cerebrospinal fluid secreting cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5886250", "l": "Cells.CD3 HLA DR", "d": [], "t": []}], "preferred_name": "Cells.CD3 HLA DR", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C4086978", "l": "iAPA-based Dendritic Cells/Cytotoxic T Lymphocytes", "d": [], "t": []}, {"i": "NCIT:C123922", "l": "iAPA-based Dendritic Cells/Cytotoxic T Lymphocytes", "d": ["A cell-based product composed of dendritic cells (DCs) pulsed with tumor-associated antigens (TAAs) and devoid of the inhibitory effect of antigen presentation attenuators (iAPA) combined with cytotoxic T-lymphocytes (CTLs) (iAPA-DC/CTL), with potential immunostimulating and antineoplastic activities.  DCs are transduced with a viral vector containing small interfering RNAs (siRNAs) against APAs, which prevents the expression of APA genes and inhibits attenuation of antigen presentation. Upon administration of iAPA-DC/CTL, the DCs are able to efficiently present antigens to the immune system, stimulate the immune system against tumor-associated antigens (TAAs) and hyperactivate TAA-specific CTLs and T-helper cells. Also, the iAPA-based DCs inhibit the activity of the T-regulatory cells (Tregs), thereby abrogating their negative effect on CTL activation and preventing their immunosuppressive activity against TAAs. Altogether, this inhibits tumor cell proliferation. Additionally, the administered CTLs induce direct cancer cell lysis. APAs negatively regulate antigen presentation, activate Tregs and their immunosuppressive activity, affect inflammatory cytokine production by DCs, and negatively regulate the immunostimulatory activity of DCs; they have an overall inhibitory effect on the stimulation of the immune system."], "t": []}], "preferred_name": "iAPA-based Dendritic Cells/Cytotoxic T Lymphocytes", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C2984032", "l": "Anti-HER2-CAR Autologous CMV-Specific Cytotoxic T-Lymphocytes", "d": [], "t": []}, {"i": "NCIT:C91091", "l": "Anti-HER2-CAR Autologous CMV-Specific Cytotoxic T-Lymphocytes", "d": ["Autologous human cytomegalovirus (CMV)-specific human cytotoxic T-lymphocytes (CTLs) transduced with a retroviral vector encoding a human anti-Her-2 (epidermal growth factor receptor 2) chimeric T cell receptor (CAR) gene with potential immunostimulatory and antineoplastic activities. Autologous CTLs from a patient with Her-2- and CMV-positive glioblastoma multiforme (GBM) are genetically modified to express CAR gene specific for Her-2 on their cell surfaces. After expansion in culture and reintroduction into the patient, the anti-HER2-CAR autologous CMV-specific CTLs bind to Her-2 antigen on tumor cell surfaces; subsequently, Her-2-positive tumor cells and stem cells may be lysed. Her-2 (ErbB-2), a receptor tyrosine kinase (RTK) overexpressed by a variety of cancer cell types, plays key roles in tumor cell proliferation and tumor angiogenesis. CMV is present in the majority of GBM tumors."], "t": []}], "preferred_name": "Anti-HER2-CAR Autologous CMV-Specific Cytotoxic T-Lymphocytes", "taxa": []}
{"type": "biolink:Cell", "ic": 92.76600187037766, "identifiers": [{"i": "CL:0000380", "l": "thecogen cell", "d": ["The support cell that makes the thecogen dendritic cap - a cuticle-like matrix around the tip of the eo-dendrite and which encloses the soma of the eo-neuron."], "t": []}], "preferred_name": "thecogen cell", "taxa": []}
{"type": "biolink:Cell", "ic": 90.871710685482, "identifiers": [{"i": "UMLS:C1710398", "l": "Thymic Epithelial Cell Capable of Differentiating Towards Cortical Cell Type", "d": [], "t": []}, {"i": "NCIT:C45705", "l": "Thymic Epithelial Cell Capable of Differentiating Towards Cortical Cell Type", "d": ["A reticular epithelial cell generated in the thymus that, in optimal condition, can become a cortex type of thymus cell that mediates positive selection of developing thymocytes."], "t": []}], "preferred_name": "Thymic Epithelial Cell Capable of Differentiating Towards Cortical Cell Type", "taxa": []}
{"type": "biolink:Cell", "ic": 92.76600187037766, "identifiers": [{"i": "UMLS:C5958727", "l": "Dendritic Melanocyte", "d": [], "t": []}, {"i": "NCIT:C204909", "l": "Dendritic Melanocyte", "d": ["A neoplastic melanocyte with dendritic morphology."], "t": []}], "preferred_name": "Dendritic Melanocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0003010", "l": "G7 retinal ganglion cell", "d": ["A bistratified retinal ganglion cell that has a dendrite field that terminates in sublaminar layer S2 and a second dendrite field that terminates in sublaminar layer S4."], "t": []}], "preferred_name": "G7 retinal ganglion cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "MESH:D011387", "l": "Prokaryotic Cells", "d": [], "t": []}], "preferred_name": "Prokaryotic Cells", "taxa": []}
{"type": "biolink:Cell", "ic": 83.63771255585968, "identifiers": [{"i": "UMLS:C1513944", "l": "Neoplastic Corticotroph Cell", "d": [], "t": []}, {"i": "NCIT:C36920", "l": "Neoplastic Corticotroph Cell", "d": [], "t": []}], "preferred_name": "Neoplastic Corticotroph Cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1718725", "l": "CD1c+CD22+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:1372987008", "l": "", "d": [], "t": []}], "preferred_name": "CD1c+CD22+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4052052", "l": "uterine natural killer cell 2, human", "d": ["A uterine natural killer subset that is present in the endometrial lining during the non-pregnant state (Garcia-Alonso et al., 2021) and in the decidua during pregnancy (Vento-Tormo et al., 2018), peaking in the first trimester. It expresses the uterine resident marker CD49a and is distinguished from uNK1 and uNK3 by the absence of CD39, CD103 (Whettlock et al., 2022), and CD160 (Marečková et al., 2024), with ITGB2 serving as a defining marker (Vento-Tormo et al., 2018). Functionally, it produces more cytokines upon stimulation than uNK1, suggesting a role in immune defense, and secretes XCL1 chemokines, facilitating interactions with maternal dendritic cells and fetal extravillous trophoblasts (Vento-Tormo et al., 2018)."], "t": []}], "preferred_name": "uterine natural killer cell 2, human", "taxa": []}
{"type": "biolink:Cell", "ic": 87.18682603146104, "identifiers": [{"i": "CL:0000175", "l": "luteal cell", "d": ["A progesterone secreting cell in the corpus luteum. The large luteal cells develop from the granulosa cells. The small luteal cells develop from the theca cells."], "t": []}], "preferred_name": "luteal cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C4049868", "l": "Gitter Cell", "d": [], "t": []}, {"i": "NCIT:C123738", "l": "Gitter Cell", "d": ["A microglial cell that is unable to phagocytose any further materials. Named for its grainy appearance, gitter cells can indicate post-infection areas that have healed."], "t": []}], "preferred_name": "Gitter Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1511043", "l": "Balloon Epithelial Cell", "d": [], "t": []}, {"i": "NCIT:C36751", "l": "Balloon Epithelial Cell", "d": [], "t": []}], "preferred_name": "Balloon Epithelial Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4047042", "l": "type 1 myenteric plexus glia", "d": ["An enteric glial cell located within the myenteric ganglia of the gastrointestinal tract. This cell has a small somata and has very short, irregularly branched processes that surround neuron cell bodies, giving it a protoplasmic-like appearance. It plays crucial roles in modulating myenteric neuron activity, regulating oxidative stress, and influencing neuroinflammation and neurogenesis."], "t": []}], "preferred_name": "type 1 myenteric plexus glia", "taxa": []}
{"type": "biolink:Cell", "ic": 92.76600187037766, "identifiers": [{"i": "CL:0008018", "l": "somatic muscle myoblast", "d": ["A myoblast that is commited to developing into a somatic muscle."], "t": []}], "preferred_name": "somatic muscle myoblast", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1441142", "l": "Reticulocytes.mature", "d": [], "t": []}], "preferred_name": "Reticulocytes.mature", "taxa": []}
{"type": "biolink:Cell", "ic": 92.76600187037766, "identifiers": [{"i": "UMLS:C1709165", "l": "Neoplastic C-Cell", "d": [], "t": []}, {"i": "NCIT:C47802", "l": "Neoplastic C-Cell", "d": [], "t": []}], "preferred_name": "Neoplastic C-Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4033023", "l": "airway submucosal gland collecting duct epithelial cell", "d": ["An epithelial cell that is part of a collecting duct of an airway submucosal gland."], "t": []}], "preferred_name": "airway submucosal gland collecting duct epithelial cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4033074", "l": "cycling CD8-positive, alpha-beta T cell", "d": ["A(n) CD8-positive, alpha-beta T cell that is cycling."], "t": []}], "preferred_name": "cycling CD8-positive, alpha-beta T cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5552711", "l": "Circulating Endothelial Cell", "d": [], "t": []}, {"i": "NCIT:C178241", "l": "Circulating Endothelial Cell", "d": ["An endothelial cell found in the peripheral blood."], "t": []}], "preferred_name": "Circulating Endothelial Cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C3476509", "l": "Siderophages", "d": [], "t": []}], "preferred_name": "Siderophages", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5163555", "l": "Epithelial cells.squamous | Bronchoalveolar lavage | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Epithelial cells.squamous | Bronchoalveolar lavage | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5177455", "l": "Plasma cells | Bone marrow | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Plasma cells | Bone marrow | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C4287595", "l": "CD16+ CD56+ CD69+ Lymphocyte", "d": [], "t": []}, {"i": "NCIT:C128465", "l": "CD16+ CD56+ CD69+ Lymphocyte", "d": ["A population of activated lymphocytes that express CD16 (Fc-gamma receptor III), CD56 (neural cell adhesion molecule 1) and CD69 (early activation antigen CD69), which is mainly comprised of natural killer cells with an activated phenotype."], "t": []}], "preferred_name": "CD16+ CD56+ CD69+ Lymphocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1522237", "l": "Thyroid Gland - Parafollicular Cell (MMHCC)", "d": [], "t": []}, {"i": "NCIT:C22651", "l": "Mouse Thyroid Gland Parafollicular Cell", "d": [], "t": []}], "preferred_name": "Thyroid Gland - Parafollicular Cell (MMHCC)", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4324118", "l": "CD28+ T lymphocyte", "d": [], "t": []}], "preferred_name": "CD28+ T lymphocyte", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5174099", "l": "Myelocytes | Fetus | Blood | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Myelocytes | Fetus | Blood | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": 83.63771255585968, "identifiers": [{"i": "CL:4052108", "l": "IgD-negative class switched memory B cell", "d": ["A class switched memory B cell that lacks IgD on the cell surface."], "t": []}], "preferred_name": "IgD-negative class switched memory B cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5157463", "l": "CD3+CD8+CD57+ cells | Blood | Cell markers", "d": [], "t": []}], "preferred_name": "CD3+CD8+CD57+ cells | Blood | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5157262", "l": "CD117 blasts | XXX | Cell markers", "d": [], "t": []}], "preferred_name": "CD117 blasts | XXX | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "CL:4023031", "l": "L4 sst Martinotti interneuron (Mmus)", "d": ["A sst GABAergic cortical interneuron with a soma found in lower L2/3 and upper 5, L4 Sst cells have Martinotti morphology with ascending axons but denser local axons and sparser ‘fanning-out’ projections to L1. L4 sst cells have smaller membrane time constant to calb2 (L2/3/5 fan Martinotti Cell) and non-zero afterdepolarization (ADP)."], "t": []}], "preferred_name": "L4 sst Martinotti interneuron (Mmus)", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C2953062", "l": "Endothelial cell of endocardium of right ventricle", "d": [], "t": []}], "preferred_name": "Endothelial cell of endocardium of right ventricle", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C2599784", "l": "Granulocytes.CD55 deficient", "d": [], "t": []}], "preferred_name": "Granulocytes.CD55 deficient", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5555048", "l": "Allogeneic Natural Killer Cells PB103", "d": [], "t": []}, {"i": "NCIT:C178455", "l": "Allogeneic Natural Killer Cells PB103", "d": ["A preparation of allogeneic, natural killer (NK) cells, with potential cytolytic and antineoplastic activities. Upon administration, allogeneic NK cells PB103 may lyse cancer cells. These cells also secrete pro-inflammatory cytokines, which further stimulate an anti-tumor immune response."], "t": []}], "preferred_name": "Allogeneic Natural Killer Cells PB103", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5381001", "l": "Cells.CD8.HLA-B7 CMV specific", "d": [], "t": []}], "preferred_name": "Cells.CD8.HLA-B7 CMV specific", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "CL:0002215", "l": "type IIb muscle cell", "d": ["A type II muscle cell that contains a low content of myoglobin, relatively few mitochondria, relatively few blood capillaries and large amounts of glycogen. Type II B fibres are white, geared to generate ATP by anaerobic metabolic processes, not able to supply skeletal muscle fibres continuously with sufficient ATP, fatigue easily, split ATP at a fast rate and have a fast contraction velocity."], "t": []}, {"i": "UMLS:C2332313", "l": "Type 2B muscle fiber", "d": [], "t": []}], "preferred_name": "type IIb muscle cell", "taxa": []}
{"type": "biolink:Cell", "ic": 70.29748386239838, "identifiers": [{"i": "UMLS:C1881589", "l": "Malignant Round Germ Cell", "d": [], "t": []}, {"i": "NCIT:C61387", "l": "Malignant Round Germ Cell", "d": [], "t": []}], "preferred_name": "Malignant Round Germ Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0000193", "l": "cardiac muscle cell (sensu Arthopoda)", "d": ["A striated muscle cell of an arthropod heart that participates in heart contraction."], "t": []}], "preferred_name": "cardiac muscle cell (sensu Arthopoda)", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1441140", "l": "Reticulocytes.aggregate", "d": [], "t": []}], "preferred_name": "Reticulocytes.aggregate", "taxa": []}
{"type": "biolink:Cell", "ic": 72.9312568671559, "identifiers": [{"i": "UMLS:C1516945", "l": "Epithelioid Endothelial Cell", "d": [], "t": []}, {"i": "NCIT:C37093", "l": "Epithelioid Endothelial Cell", "d": [], "t": []}], "preferred_name": "Epithelioid Endothelial Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1511638", "l": "Cytotrophoblastic Cell", "d": [], "t": []}, {"i": "NCIT:C38575", "l": "Cytotrophoblastic Cell", "d": ["A polygonal, mononucleate cell resembling the cells of the inner layer of the trophoblast, having prominent nucleoli and clear, eosinophilic or basophilic cytoplasm."], "t": []}], "preferred_name": "Cytotrophoblastic Cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5157683", "l": "CD8-CD57+ cells | Blood | Cell markers", "d": [], "t": []}], "preferred_name": "CD8-CD57+ cells | Blood | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5157631", "l": "CD61 cells | Blood | Cell markers", "d": [], "t": []}], "preferred_name": "CD61 cells | Blood | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": 92.76600187037766, "identifiers": [{"i": "CL:0010006", "l": "cardiac blood vessel endothelial cell", "d": ["Any blood vessel endothelial cell that is part of some heart."], "t": []}], "preferred_name": "cardiac blood vessel endothelial cell", "taxa": []}
{"type": "biolink:Cell", "ic": 75.54735764213513, "identifiers": [{"i": "CL:0019031", "l": "intestine goblet cell", "d": ["Goblet cells reside throughout the length of the small and large intestine and are responsible for the production and maintenance of the protective mucus blanket by synthesizing and secreting high-molecular-weight glycoproteins known as mucins. Human intestinal goblet cells secrete the MUC2 mucin, as well as a number of typical mucus components: CLCA1, FCGBP, AGR2, ZG16, and TFF3."], "t": []}], "preferred_name": "intestine goblet cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1440143", "l": "Blasts.CD19", "d": [], "t": []}], "preferred_name": "Blasts.CD19", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4307066", "l": "Tanycyte NN_2 Mroh5 alpha1-tanycyte (Mmus)", "d": ["A alpha1-tanycyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Ccdc170 (Mmus), Nkx2-4 (Mmus), Dock8 (Mmus). It is distinguished from other Tanycyte NN_2 cells by expression of Mroh5. These cells are located in the Hypothalamus, brain , in or close to the regions: Periventricular hypothalamic nucleus, intermediate part, third ventricle, Arcuate hypothalamic nucleus . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5246 Tanycyte NN_2."], "t": []}], "preferred_name": "Tanycyte NN_2 Mroh5 alpha1-tanycyte (Mmus)", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C2369073", "l": "MRC-5 cell line components", "d": [], "t": []}], "preferred_name": "MRC-5 cell line components", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1519477", "l": "Splenocyte", "d": [], "t": []}, {"i": "NCIT:C12951", "l": "Splenocyte", "d": ["A vague term that usually refers to the phagocytic cells (macrophages) of the spleen."], "t": []}], "preferred_name": "Splenocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C3831515", "l": "Anti-EGFRvIII CAR-transduced Allogeneic T-lymphocytes", "d": [], "t": []}, {"i": "NCIT:C111565", "l": "Anti-EGFRvIII CAR-transduced Allogeneic T-lymphocytes", "d": ["Allogeneic human T-lymphocytes transduced with a retroviral vector encoding an anti-epidermal growth factor receptor (EGFR) variant III (EGFRvIII) mutant chimeric T cell receptor (chimeric antigen receptor or CAR) gene coupled to the signaling domains from CD8, CD28, 4-1BB (CD137) and CD3 zeta, with potential immunostimulatory and antineoplastic activities. Upon administration, the anti-EGFRvIII CAR-transduced allogeneic T lymphocytes bind to the EGFRvIII antigen on tumor cell surfaces; subsequently, EGFRvIII-expressing tumor cells may be lysed. EGFRvIII, an in-frame deletion of exons 2-7 in the EGFR gene, is overexpressed by a variety of cancer cell types and absent in normal, healthy cells; it plays a key role in tumor cell proliferation, tumor angiogenesis and radio- and chemoresistance."], "t": []}], "preferred_name": "Anti-EGFRvIII CAR-transduced Allogeneic T-lymphocytes", "taxa": []}
{"type": "biolink:Cell", "ic": 87.18682603146104, "identifiers": [{"i": "UMLS:C0333850", "l": "Hairy cell", "d": [], "t": []}, {"i": "NCIT:C25288", "l": "Hairy Cell", "d": ["An abnormal large leukocyte found in the blood in hairy cell leukemia; it has numerous irregular cytoplasmic villi that give it a flagellated or hairy appearance."], "t": []}, {"i": "SNOMEDCT:112661003", "l": "", "d": [], "t": []}], "preferred_name": "Hairy cell", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "UMLS:C0229650", "l": "Megakaryoblasts", "d": [], "t": []}, {"i": "NCIT:C13122", "l": "Megakaryoblast", "d": ["The precursor of a megakaryocyte."], "t": []}, {"i": "SNOMEDCT:27852005", "l": "", "d": [], "t": []}], "preferred_name": "Megakaryoblasts", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5163726", "l": "Erythrocytes | Stool | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Erythrocytes | Stool | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": 87.18682603146104, "identifiers": [{"i": "CL:4023025", "l": "long-range projecting sst GABAergic cortical interneuron (Mmus)", "d": ["A sst GABAergic cortical interneuron that is both an interneuron and a projecting neuron. They are found in all layers from upper L2/3 down to the bottom of L6. They have long-range projections, some with axons fading into white matter. These cells have low rebound potential, low hyperpolarization sag, and high variability in membrane time constant."], "t": []}], "preferred_name": "long-range projecting sst GABAergic cortical interneuron (Mmus)", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:1000321", "l": "large intestine crypt goblet cell", "d": ["A goblet cell that is part of the epithelium of crypt of Lieberkuhn of large intestine."], "t": []}, {"i": "UMLS:C2330822", "l": "Goblet cell of epithelium of crypt of Lieberkuhn of large intestine", "d": [], "t": []}], "preferred_name": "large intestine crypt goblet cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0002450", "l": "tether cell", "d": ["A specialized hair cell that has an elongated kinocilium upon which an otolith accretes. The tether cell then anchors the otolith in place."], "t": []}], "preferred_name": "tether cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C3496528", "l": "A5 noradrenaline cells", "d": [], "t": []}], "preferred_name": "A5 noradrenaline cells", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0597447", "l": "Sf9 cell line", "d": [], "t": []}], "preferred_name": "Sf9 cell line", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1545485", "l": "Parabasal epithelial cell", "d": [], "t": []}, {"i": "SNOMEDCT:725265002", "l": "", "d": [], "t": []}], "preferred_name": "Parabasal epithelial cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5170942", "l": "Leukocytes | Urethra | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Leukocytes | Urethra | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4310111", "l": "SN-VTR GAD2 Dopa dopaminergic neuron (Primate)", "d": ["A dopaminergic neuron of the Primates brain. These cells are located in the striatum, substantia nigra . Reference transcriptomic data for this type can be found in the dataset/taxonomy - HMBA Basal Ganglia Consensus Taxonomy in cell set Group:SN-VTR GAD2 Dopa."], "t": []}], "preferred_name": "SN-VTR GAD2 Dopa dopaminergic neuron (Primate)", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:1001209", "l": "inner medulla vasa recta ascending limb cell", "d": ["Any vasa recta ascending limb cell that is part of some inner medulla ascending vasa recta."], "t": []}], "preferred_name": "inner medulla vasa recta ascending limb cell", "taxa": []}
{"type": "biolink:Cell", "ic": 92.76600187037766, "identifiers": [{"i": "CL:1001145", "l": "interlobular vein cell", "d": ["Any kidney cortex vein cell that is part of some renal interlobular vein."], "t": []}], "preferred_name": "interlobular vein cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1267816", "l": "Lymphocyte positive for CD3 antigen", "d": [], "t": []}, {"i": "SNOMEDCT:116852002", "l": "", "d": [], "t": []}], "preferred_name": "Lymphocyte positive for CD3 antigen", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5216212", "l": "Erythrocytes|NCnc|Pt|CSF", "d": [], "t": []}], "preferred_name": "Erythrocytes|NCnc|Pt|CSF", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1267987", "l": "Lymphocyte positive for CD100 antigen", "d": [], "t": []}, {"i": "SNOMEDCT:117427004", "l": "", "d": [], "t": []}], "preferred_name": "Lymphocyte positive for CD100 antigen", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4033116", "l": "cervicothoracic ganglion VIP neuron", "d": ["A sympathetic neuron that has the soma located in the cervicothoracic ganglion and expresses the marker vasoactive intestinal peptide (VIP)."], "t": []}], "preferred_name": "cervicothoracic ganglion VIP neuron", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C4289937", "l": "Baltaleucel-T", "d": [], "t": []}, {"i": "NCIT:C129374", "l": "Baltaleucel-T", "d": ["A preparation of autologous Epstein-Barr virus (EBV)-specific cytotoxic T-lymphocytes (CTLs), which have specific reactivity to the EBV antigens, latent membrane proteins (LMP) 1 (LMP1) and 2 (LMP2), EBV nuclear antigen (EBNA) and BamHI-A rightward frame-1 (BARF1), with potential immunomodulating and antineoplastic activities. Upon administration, baltaleucel-T targets and binds to EBV-expressing cancer cells specifically expressing the targeted antigens. This may kill LMP1/LMP2/EBNA/BARF1-expressing EBV-associated cancer cells. LMP1, LMP2, EBNA and BARF1 are tumor-associated antigens (TAAs) that are specifically associated with EBV infection, and play key roles in the proliferation of a variety of tumors."], "t": []}], "preferred_name": "Baltaleucel-T", "taxa": []}
{"type": "biolink:Cell", "ic": 83.63771255585968, "identifiers": [{"i": "CL:0002548", "l": "fibroblast of cardiac tissue", "d": ["A fibroblast that is part of the heart."], "t": []}], "preferred_name": "fibroblast of cardiac tissue", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1514007", "l": "Neoplastic Large Pleomorphic Germ Cell", "d": [], "t": []}, {"i": "NCIT:C36905", "l": "Neoplastic Large Pleomorphic Germ Cell", "d": [], "t": []}], "preferred_name": "Neoplastic Large Pleomorphic Germ Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 48.59281005584928, "identifiers": [{"i": "UMLS:C1512104", "l": "Dysplastic Glandular Cell", "d": [], "t": []}, {"i": "NCIT:C36794", "l": "Dysplastic Glandular Cell", "d": [], "t": []}], "preferred_name": "Dysplastic Glandular Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0002667", "l": "type V spiral ligament fibrocyte", "d": ["A spiral ligament fibrocyte located in the suprastrial region above the stria vascularis, distinguished from other fibrocytes by their unique expression of COX-1 in guinea pigs and end-foot structures that directly contact capillaries (Dai and Shi, 2011). This fibro-vascular coupling enables type V fibrocytes to regulate cochlear blood flow by translating Ca²⁺ signals into capillary vasodilation via COX-1-derived prostaglandins. This cell also participates in K⁺ recycling, expressing Na,K-ATPase (ATP1A1, ATP1B1) in mice and humans, and connexin 26/30 gap junctions enabling intercellular K⁺ transport within the spiral ligament syncytium (Peeleman et al., 2020)."], "t": []}], "preferred_name": "type V spiral ligament fibrocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 92.76600187037766, "identifiers": [{"i": "UMLS:C1711306", "l": "Malignant Thyroid Gland Follicular Clear Cell", "d": [], "t": []}, {"i": "NCIT:C47821", "l": "Malignant Thyroid Gland Follicular Clear Cell", "d": [], "t": []}], "preferred_name": "Malignant Thyroid Gland Follicular Clear Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0000286", "l": "hyphal cell", "d": ["A cell of a filament of a fungal mycelium."], "t": []}], "preferred_name": "hyphal cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5761404", "l": "Cell positive for progesterone receptor", "d": [], "t": []}, {"i": "SNOMEDCT:1234916001", "l": "", "d": [], "t": []}], "preferred_name": "Cell positive for progesterone receptor", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0229645", "l": "Basophilic promyelocyte", "d": [], "t": []}, {"i": "SNOMEDCT:71170001", "l": "", "d": [], "t": []}], "preferred_name": "Basophilic promyelocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0000565", "l": "fat body cell", "d": ["A cell found in fat bodies whose primary function is intermediary metabolism."], "t": []}], "preferred_name": "fat body cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4307005", "l": "CB PLI GABA Ly6d Purkinje layer interneuron", "d": ["A Purkinje layer interneuron of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Ly6d (Mmus), Kit (Mmus). It is distinguished from other CB PLI Gly-Gaba cells by expression of Ly6d. It is GABAergic. These cells are located in the Cerebellum, brain , in or close to the regions: arbor vitae, Interposed nucleus, Nodulus (X) . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5185 CB PLI Gly-Gaba_4.", "A Purkinje layer interneuron of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Ly6d (Mmus), Kit (Mmus). It is distinguished from other CB PLI Gly-Gaba cells by expression of Ly6d. It is GABAergic (inferred from expression of Gad1, Gad2, Slc32a1). These cells are located in the Cerebellum, brain , in or close to the regions: arbor vitae, Interposed nucleus, Nodulus (X) . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5185 CB PLI Gly-Gaba_4."], "t": []}], "preferred_name": "CB PLI GABA Ly6d Purkinje layer interneuron", "taxa": []}
{"type": "biolink:Cell", "ic": 92.76600187037766, "identifiers": [{"i": "CL:1000435", "l": "epithelial cell of lacrimal drainage system", "d": ["An epithelial cell that is part of the lacrimal drainage system."], "t": []}, {"i": "UMLS:C1182618", "l": "Epithelial cell of lacrimal duct", "d": [], "t": []}], "preferred_name": "epithelial cell of lacrimal drainage system", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0229542", "l": "Pituitary amphophil cell", "d": [], "t": []}, {"i": "SNOMEDCT:19992001", "l": "", "d": [], "t": []}], "preferred_name": "Pituitary amphophil cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1267808", "l": "SMIG+ lymphocyte", "d": [], "t": []}, {"i": "SNOMEDCT:117512001", "l": "", "d": [], "t": []}], "preferred_name": "SMIG+ lymphocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0002360", "l": "AGM hematopoietic stem cell", "d": ["A hematopoietic stem cell from the aorta-gonad-mesonephros region of the developing embryo. First seen at E10.5 in mouse embryos. May give rise to fetal liver HSC."], "t": []}], "preferred_name": "AGM hematopoietic stem cell", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "CL:0000892", "l": "smooth muscle cell derived foam cell", "d": ["A type of foam cell derived from a smooth muscle cell containing lipids in small vacuoles and typically seen in atherolosclerotic lesions, as well as other conditions."], "t": []}], "preferred_name": "smooth muscle cell derived foam cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5170917", "l": "Leukocytes | Blood | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Leukocytes | Blood | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C0333857", "l": "Centroblast", "d": [], "t": []}, {"i": "NCIT:C32932", "l": "Centroblast", "d": ["An activated B-lymphocyte found in the germinal centers.  It has a large nucleus without clefts, finely dispersed chromatin, and a rim of basophilic cytoplasm."], "t": []}, {"i": "SNOMEDCT:55134005", "l": "", "d": [], "t": []}], "preferred_name": "Centroblast", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4310124", "l": "striatal SST-RSPO2 GABAergic interneuron (Primate)", "d": ["A sst GABAergic interneuron of the Primates brain. These cells are located in the striatum . Reference transcriptomic data for this type can be found in the dataset/taxonomy - HMBA Basal Ganglia Consensus Taxonomy in cell set Group:STR SST-RSPO2 GABA."], "t": []}], "preferred_name": "striatal SST-RSPO2 GABAergic interneuron (Primate)", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "CL:4047053", "l": "TREM2-positive macrophage", "d": ["A macrophage characterized by high expression of Triggering Receptor Expressed on Myeloid cells 2 (TREM2), found in various tissues including the liver, adipose tissue, bone, gut (Colonna, 2023), and tumor microenvironments, where it is associated with immunosuppressive and anti-inflammatory activity (Colmenares, 2024; Khantakova, 2022). This cell exhibits a distinct gene expression profile in the tumor microenvironment, including overexpression of complement system genes (C1QA, C1QB, C1QC, C3), and SPP1 in both mice and humans (Xiong, 2020; Khantakova, 2022). It is involved in phagocytosis, tissue repair, and modulation of immune responses (Coeho, 2021)."], "t": []}], "preferred_name": "TREM2-positive macrophage", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1267856", "l": "Lymphocyte positive for both CD8 antigen and CD38 antigen", "d": [], "t": []}, {"i": "SNOMEDCT:116817005", "l": "", "d": [], "t": []}], "preferred_name": "Lymphocyte positive for both CD8 antigen and CD38 antigen", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C2332996", "l": "Thrombocytopoietic cell", "d": [], "t": []}], "preferred_name": "Thrombocytopoietic cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0546491", "l": "P.B. myeloblast", "d": [], "t": []}], "preferred_name": "P.B. myeloblast", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C0025207", "l": "Melanophores", "d": [], "t": []}, {"i": "NCIT:C12582", "l": "Melanophore", "d": ["A specialized cell, derived from the neural crest, that contains melanin and regulates changes in pigment."], "t": []}, {"i": "MESH:D008547", "l": "Melanophores", "d": [], "t": []}], "preferred_name": "Melanophores", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5571780", "l": "Siderocytes.Type 2", "d": [], "t": []}], "preferred_name": "Siderocytes.Type 2", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0000524", "l": "spheroplast", "d": ["A cell, usually of bacteria or yeast, which has partially lost its cell wall."], "t": []}, {"i": "UMLS:C0037890", "l": "Spheroplasts", "d": [], "t": []}, {"i": "NCIT:C12661", "l": "Spheroplast", "d": ["A cell that has lost it's typical shape and becomes spherical due to partial loss of the cell wall."], "t": []}, {"i": "MESH:D013104", "l": "Spheroplasts", "d": [], "t": []}], "preferred_name": "spheroplast", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1522171", "l": "Mouse Club Cell", "d": [], "t": []}, {"i": "NCIT:C22603", "l": "Mouse Club Cell", "d": [], "t": []}], "preferred_name": "Mouse Club Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5206698", "l": "AUTO3", "d": [], "t": []}, {"i": "NCIT:C162620", "l": "Autologous Anti-CD19/CD22 CAR T-cells AUTO3", "d": ["A preparation of autologous T-lymphocytes that have been transduced with a bicistronic retroviral vector encoding both an anti-CD19 chimeric antigen receptor (CAR) fused to OX40 co-stimulatory domain and an anti-CD22 CAR linked to the intracellular signaling domains of 4-1BB (CD137) and the zeta chain of the TCR/CD3 complex (TCRzeta; CD247; CD3zeta), optimized with a novel pentameric spacer derived from the collagen oligomeric matrix protein (COMP), with potential antineoplastic activity. Upon administration, the autologous anti-CD19/CD22 CAR T-cells AUTO3 bind to and induce selective toxicity in tumor cells expressing CD19 and CD22. CD19 and CD22, both transmembrane phosphoglycoproteins expressed on the surface of cells in the B lineage, are often overexpressed on malignant B-cells. By simultaneously targeting two B-cell antigens, this preparation may minimize relapse due to single antigen loss in patients with B-cell malignancies."], "t": []}], "preferred_name": "AUTO3", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C4289596", "l": "Effector Memory T Cells", "d": [], "t": []}, {"i": "NCIT:C126419", "l": "Effector Memory T-Lymphocyte", "d": ["Long-lived antigen-specific T-lymphocytes, which express CD8 and effector cytokines. Upon subsequent exposure to their target antigen, these cells rapidly become effector cells."], "t": []}], "preferred_name": "Effector Memory T Cells", "taxa": []}
{"type": "biolink:Cell", "ic": 85.53200374075534, "identifiers": [{"i": "CL:0000687", "l": "R1 photoreceptor cell", "d": [], "t": []}], "preferred_name": "R1 photoreceptor cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C2986403", "l": "Anti-CTLA4 MoAb RNA/GITRL RNA-transfected Autologous Dendritic Cell Vaccine", "d": [], "t": []}, {"i": "NCIT:C94218", "l": "Anti-CTLA4 MoAb RNA/GITRL RNA-transfected Autologous Dendritic Cell Vaccine", "d": ["An autologous dendritic cell (DC) cancer vaccine with potential immunostimulatory activity. Anti-CTLA4 MoAb RNA/GITRL RNA-transfected DC vaccine is prepared by transfecting DCs with RNAs encoding humanized heavy and light chains of the anti-CTLA4 (cytotoxic T-Lymphocyte-Associated Antigen 4) monoclonal antibody and tumor necrosis factor (ligand) superfamily, member 18 (TNFSF18 or GlTRL); expression of anti-CTLA4 blocks the inhibitory effect of CTLA4 on the activation of T-lymphocytes, while expression of GlTRL modulates T lymphocyte survival in peripheral tissues. Co-vaccination of this vaccine with melanoma antigen specific vaccine may eliminate the adverse effects associated with systemic administration of immune modulators, while also enhancing vaccine-induced immune responses."], "t": []}], "preferred_name": "Anti-CTLA4 MoAb RNA/GITRL RNA-transfected Autologous Dendritic Cell Vaccine", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5417979", "l": "Autologous AFP Specific T Cell Receptor Transduced T Cells C-TCR055", "d": [], "t": []}, {"i": "NCIT:C173429", "l": "Autologous AFP Specific T Cell Receptor Transduced T Cells C-TCR055", "d": ["A preparation of human autologous T-lymphocytes transduced with a lentiviral vector encoding for a T-cell receptor (TCR) recognizing the human leukocyte antigen (HLA)-A*02:01 restricted human alpha-fetoprotein (AFP) 158-166 peptide (FMNKFIYEI), with potential antineoplastic activity. Upon isolation, transduction, expansion ex vivo, and reintroduction into the patient, the AFP specific TCR transduced T cells recognize and bind to AFP antigen-positive cells, which results in lysis and killing of AFP-positive cancer cells. AFP is overexpressed in a variety of cancers while its expression is restricted in normal tissues."], "t": []}], "preferred_name": "Autologous AFP Specific T Cell Receptor Transduced T Cells C-TCR055", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5555034", "l": "Anti-MSLN CAR-T Cells LCAR-M23", "d": [], "t": []}, {"i": "NCIT:C178439", "l": "Anti-MSLN CAR-T Cells LCAR-M23", "d": ["A preparation of T-lymphocytes that have been genetically modified to express a chimeric antigen receptor (CAR) specific for the human tumor-associated antigen (TAA) mesothelin (MSLN), with potential immunomodulating and antineoplastic activities. Upon administration, the anti-MSLN CAR-T cells LCAR-M23 specifically target and kill MSLN-expressing tumor cells. Mesothelin, a cell surface glycoprotein involved in cell adhesion, is overexpressed in a variety of cancer cell types."], "t": []}], "preferred_name": "Anti-MSLN CAR-T Cells LCAR-M23", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1440384", "l": "Cells.euploid+Cells.aneuploid", "d": [], "t": []}], "preferred_name": "Cells.euploid+Cells.aneuploid", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5690734", "l": "Nasopharynx-Associated Lymphoid Tissue M Cells", "d": [], "t": []}], "preferred_name": "Nasopharynx-Associated Lymphoid Tissue M Cells", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0002162", "l": "internal epithelial cell of tympanic membrane", "d": ["An extremely flattened cell type found on the inner side of the tympanic membrane. The surface of this cell type carries sparse pleomorphic microvilli that are more common near the junctional zones."], "t": []}, {"i": "UMLS:C1182665", "l": "Internal epithelial cell of tympanic membrane", "d": [], "t": []}], "preferred_name": "internal epithelial cell of tympanic membrane", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1183210", "l": "Set of tubal air cells", "d": [], "t": []}], "preferred_name": "Set of tubal air cells", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5157381", "l": "CD20+CD25- cells | Blood | Cell markers", "d": [], "t": []}], "preferred_name": "CD20+CD25- cells | Blood | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": 64.39556439996649, "identifiers": [{"i": "CL:0000514", "l": "smooth muscle myoblast", "d": ["A precursor cell destined to differentiate into smooth muscle myocytes."], "t": []}, {"i": "UMLS:C1135919", "l": "Myoblasts, Smooth Muscle", "d": [], "t": []}, {"i": "MESH:D032390", "l": "Myoblasts, Smooth Muscle", "d": [], "t": []}], "preferred_name": "smooth muscle myoblast", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5401590", "l": "IL15-NK Cell", "d": [], "t": []}], "preferred_name": "IL15-NK Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 78.05853671694304, "identifiers": [{"i": "CL:2000022", "l": "cardiac septum cell", "d": ["Any native cell that is part of a cardiac septum."], "t": []}], "preferred_name": "cardiac septum cell", "taxa": []}
{"type": "biolink:Cell", "ic": 73.98236851641934, "identifiers": [{"i": "CL:1001579", "l": "cerebral cortex glial cell", "d": ["Glial cell of cerebral cortex."], "t": []}], "preferred_name": "cerebral cortex glial cell", "taxa": []}
{"type": "biolink:Cell", "ic": 83.63771255585968, "identifiers": [{"i": "CL:0002438", "l": "NK1.1-positive natural killer cell, mouse", "d": ["A mature NK cell that is NK1.1-positive."], "t": []}], "preferred_name": "NK1.1-positive natural killer cell, mouse", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C4053747", "l": "Allogeneic Mesothelioma Tumor Lysate-pulsed Autologous Dendritic Cell Vaccine", "d": [], "t": []}, {"i": "NCIT:C121640", "l": "Allogeneic Mesothelioma Tumor Lysate-pulsed Autologous Dendritic Cell Vaccine", "d": ["A cell-based cancer vaccine composed of autologous dendritic cells (DCs) pulsed with a mixture of lysates from five allogeneic mesothelioma tumor cell lines, with potential immunostimulatory and antineoplastic activities. Upon leukapheresis, DCs are loaded with allogeneic mesothelioma tumor cell lysates. Upon re-administration of the allogeneic mesothelioma tumor lysate-pulsed autologous DC vaccine, the immune system is exposed to an undefined amount of mesothelioma-associated antigens, which stimulates the induction of a specific cytotoxic T-lymphocyte (CTL) response against mesothelioma tumor cells and leads to tumor cell lysis."], "t": []}], "preferred_name": "Allogeneic Mesothelioma Tumor Lysate-pulsed Autologous Dendritic Cell Vaccine", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:1000366", "l": "transitional myocyte of middle internodal tract", "d": ["A transitional myocyte that is part of the middle internodal tract."], "t": []}, {"i": "UMLS:C2333912", "l": "Transitional myocyte of middle internodal tract", "d": [], "t": []}], "preferred_name": "transitional myocyte of middle internodal tract", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:1000483", "l": "Purkinje myocyte of internodal tract", "d": ["A Purkinje myocyte that is part of the internodal tract."], "t": []}, {"i": "UMLS:C2323184", "l": "Purkinje myocyte of internodal tract", "d": [], "t": []}], "preferred_name": "Purkinje myocyte of internodal tract", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4322726", "l": "Mesothelial cell of arachnoid mater", "d": [], "t": []}], "preferred_name": "Mesothelial cell of arachnoid mater", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:1001568", "l": "pulmonary artery endothelial cell", "d": ["Any endothelial cell of vascular tree that is part of some pulmonary artery."], "t": []}], "preferred_name": "pulmonary artery endothelial cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0483187", "l": "CD19+SmIg lambda+", "d": [], "t": []}], "preferred_name": "CD19+SmIg lambda+", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5216304", "l": "Other cells|NCnc|Pt|Bld", "d": [], "t": []}], "preferred_name": "Other cells|NCnc|Pt|Bld", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0002008", "l": "CD34-positive, CD38-positive eosinophil progenitor cell", "d": ["A lineage marker-negative, CD34-positive, CD38-positive, IL3r-alpha-positive, IL5r-alpha-positive, and CD45RA-negative eosinophil progenitor cell."], "t": []}], "preferred_name": "CD34-positive, CD38-positive eosinophil progenitor cell", "taxa": []}
{"type": "biolink:Cell", "ic": 75.08236434612573, "identifiers": [{"i": "UMLS:C1708873", "l": "Malignant Epithelial Large Cell with Vesicular Nucleus and Distinct Nucleolus", "d": [], "t": []}, {"i": "NCIT:C54387", "l": "Malignant Epithelial Large Cell with Vesicular Nucleus and Distinct Nucleolus", "d": [], "t": []}], "preferred_name": "Malignant Epithelial Large Cell with Vesicular Nucleus and Distinct Nucleolus", "taxa": []}
{"type": "biolink:Cell", "ic": 78.29800561113302, "identifiers": [{"i": "CL:0000177", "l": "testosterone secreting cell", "d": ["Any secretory cell that is capable of some testosterone secretion."], "t": []}], "preferred_name": "testosterone secreting cell", "taxa": []}
{"type": "biolink:Cell", "ic": 80.61184433509295, "identifiers": [{"i": "CL:0000545", "l": "T-helper 1 cell", "d": ["A CD4-positive, alpha-beta T cell that has the phenotype T-bet-positive, CXCR3-positive, CCR6-negative, and is capable of producing interferon-gamma."], "t": []}, {"i": "UMLS:C0242632", "l": "T-helper cell type 1", "d": [], "t": []}, {"i": "NCIT:C12539", "l": "Type 1 Helper Cell", "d": ["Type 1 Helper Cells are a subset of helper-inducer T-lymphocytes which synthesize and secrete interleukin-2, gamma-interferon, and interleukin-12. Due to their ability to kill antigen-presenting cells and their lymphokine-mediated effector activity, these cells are associated with delayed-type hypersensitivity reactions."], "t": []}, {"i": "MESH:D018417", "l": "Th1 Cells", "d": [], "t": []}, {"i": "SNOMEDCT:418698006", "l": "", "d": [], "t": []}], "preferred_name": "T-helper 1 cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0001075", "l": "KLRG1-positive innate lymphoid cell, human", "d": ["An innate lymphoid cell in the human with the phenotype KLRG1-positive that is a precusor for ILC2 cells."], "t": []}], "preferred_name": "KLRG1-positive innate lymphoid cell, human", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0004241", "l": "WF2 amacrine cell", "d": ["An amacrine cell with a wide dendritic field, dendrites in S2, and post-synaptic terminals in S1."], "t": []}], "preferred_name": "WF2 amacrine cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0000418", "l": "arcade cell", "d": ["An epithelial cell found in C. elegans that firmly hold the outer body wall and the lips to the inner cylinder of the pharynx in a manner that keeps these organs from breaking apart, while still giving each organ freedom of movement during feeding."], "t": []}], "preferred_name": "arcade cell", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "CL:0002569", "l": "mesenchymal stem cell of umbilical cord", "d": ["A mesenchymal stem cell of the umbilical cord."], "t": []}], "preferred_name": "mesenchymal stem cell of umbilical cord", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4033108", "l": "middle cervical ganglion DBH neuron", "d": ["A sympathetic neuron that has the soma located in the middle cervical ganglion and expresses the marker dopamine beta-hydroxylase (DBH)."], "t": []}], "preferred_name": "middle cervical ganglion DBH neuron", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5175147", "l": "Nucleated cells | Bone marrow | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Nucleated cells | Bone marrow | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": 90.871710685482, "identifiers": [{"i": "CL:0002668", "l": "type IV spiral ligament fibrocyte", "d": ["A spiral ligament fibrocyte that is located in the triangular space inferior to the crista basilaris (basilar crest). This cell is spindle-shaped and expresses NKCC1 but minimal to no Na,K-ATPase (ATP1A1, ATP1B1) in mice and humans, and lacks connexin 26/30 in mice, indicating it does not participate in K⁺ recycling, unlike type II fibrocytes. Type IV fibrocyte is uniquely characterised by strong expression of connective tissue growth factor (CTGF) in mice, suggesting roles in tissue remodelling and paracrine signalling to other cochlear cells."], "t": []}], "preferred_name": "type IV spiral ligament fibrocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C0949753", "l": "Nitrergic Neurons", "d": [], "t": []}, {"i": "NCIT:C12647", "l": "Nitrergic Neuron", "d": ["A nerve cell that uses nitric oxide as its neurotransmitter."], "t": []}, {"i": "MESH:D026602", "l": "Nitrergic Neurons", "d": [], "t": []}], "preferred_name": "Nitrergic Neurons", "taxa": []}
{"type": "biolink:Cell", "ic": 80.96785908349635, "identifiers": [{"i": "CL:0002430", "l": "CD4-intermediate, CD8-positive double-positive thymocyte", "d": ["A double-positive thymocyte that is undergoing positive selection, has high expression of the alpha-beta T cell receptor, is CD69-positive, and is in the process of down regulating the CD4 co-receptor."], "t": []}], "preferred_name": "CD4-intermediate, CD8-positive double-positive thymocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1510967", "l": "Atypical Transitional Cell", "d": [], "t": []}, {"i": "NCIT:C36911", "l": "Atypical Transitional Cell", "d": [], "t": []}], "preferred_name": "Atypical Transitional Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 66.33925318234348, "identifiers": [{"i": "CL:0002191", "l": "granulocytopoietic cell", "d": ["A cell involved in the formation of a granulocyte."], "t": []}, {"i": "UMLS:C1268007", "l": "Myeloid precursor cell", "d": [], "t": []}, {"i": "SNOMEDCT:127914007", "l": "", "d": [], "t": []}], "preferred_name": "granulocytopoietic cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5783437", "l": "Tremtelectogene Empogeditemcel", "d": [], "t": []}], "preferred_name": "Tremtelectogene Empogeditemcel", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0000309", "l": "copper accumulating cell", "d": [], "t": []}], "preferred_name": "copper accumulating cell", "taxa": []}
{"type": "biolink:Cell", "ic": 54.18092153036562, "identifiers": [{"i": "CL:1100001", "l": "secretory epithelial cell", "d": ["An epithelial cell that is specialised for the synthesis and secretion of specific biomolecules."], "t": []}], "preferred_name": "secretory epithelial cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0008013", "l": "cranial visceromotor neuron", "d": ["A visceromotor motor neuron whose soma is located in the hindbrain, and which synapses to parasympathetic neurons that innervate tear glands, sweat glands, and the smooth muscles of the head."], "t": []}], "preferred_name": "cranial visceromotor neuron", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0000967", "l": "Bm5 B cell", "d": ["A memory B cell arising in the germinal center that is IgD-negative and has undergone somatic mutation of the variable region of the immunoglobulin heavy and light chain genes."], "t": []}], "preferred_name": "Bm5 B cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0020054", "l": "Dogiel type II neuron of myenteric plexus", "d": ["An intrinsic primary afferent neuron of the myenteric plexus characterised by Dogiel type II morphology: a large, smooth, oval soma bearing multiple long axon-like processes that extend without branching until they reach their targets in both the myenteric and submucosal plexuses and the mucosa. The soma lacks the dendrites characteristic of Dogiel type I neurons and is larger in cross-sectional area than either motor neuron type. This neuron is immunopositive for choline acetyltransferase (ChAT) and immunonegative for neuronal nitric oxide synthase (NOS1). It exhibits AH-type electrophysiology, characterised by a prolonged afterhyperpolarization (AHP) following an action potential. Substance P (encoded by TAC1) expression has been reported in subsets across species."], "t": []}], "preferred_name": "Dogiel type II neuron of myenteric plexus", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C3496152", "l": "A8 dopamine cells", "d": [], "t": []}], "preferred_name": "A8 dopamine cells", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4510900", "l": "Blast cell positive for CD1 antigen", "d": [], "t": []}, {"i": "SNOMEDCT:724246004", "l": "", "d": [], "t": []}], "preferred_name": "Blast cell positive for CD1 antigen", "taxa": []}
{"type": "biolink:Cell", "ic": 90.871710685482, "identifiers": [{"i": "CL:1000275", "l": "smooth muscle cell of small intestine", "d": ["A smooth muscle cell that is part of the small intestine."], "t": []}, {"i": "UMLS:C0734262", "l": "Smooth muscle fiber of small intestine", "d": [], "t": []}], "preferred_name": "smooth muscle cell of small intestine", "taxa": []}
{"type": "biolink:Cell", "ic": 48.518225630527226, "identifiers": [{"i": "CL:0000526", "l": "afferent neuron", "d": ["A neuron which conveys sensory information centrally from the periphery."], "t": []}], "preferred_name": "afferent neuron", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C2340138", "l": "Hepatic Stellate Cells", "d": [], "t": []}, {"i": "MESH:D055166", "l": "Hepatic Stellate Cells", "d": [], "t": []}], "preferred_name": "Hepatic Stellate Cells", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5777123", "l": "CD8+ enriched young tumor infiltrating lymphocytes", "d": [], "t": []}], "preferred_name": "CD8+ enriched young tumor infiltrating lymphocytes", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4307043", "l": "Astro-TE NN_2 Mcm6 astrocyte (Mmus)", "d": ["A astrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Mcm6 (Mmus), Egfr (Mmus), Pcsk6 (Mmus). It is distinguished from other Astro-TE NN_2 cells by expression of Mcm6. These cells are located in the Hippocampal region , in or close to the regions: Dentate gyrus, molecular layer, Dentate gyrus, polymorph layer, Dentate gyrus, granule cell layer . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5223 Astro-TE NN_2."], "t": []}], "preferred_name": "Astro-TE NN_2 Mcm6 astrocyte (Mmus)", "taxa": []}
{"type": "biolink:Cell", "ic": 53.6231242045731, "identifiers": [{"i": "UMLS:C0229613", "l": "lymphoblast", "d": [], "t": []}, {"i": "NCIT:C13013", "l": "Lymphoblast", "d": ["An immature lymphocyte that has enlarged in response to antigenic stimulation."], "t": []}, {"i": "SNOMEDCT:15433008", "l": "", "d": [], "t": []}], "preferred_name": "lymphoblast", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0000415", "l": "diploid cell", "d": ["A cell whose nucleus has two haploid genomes."], "t": []}], "preferred_name": "diploid cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5163718", "l": "Erythrocytes | Fetus | Pleural fluid | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Erythrocytes | Fetus | Pleural fluid | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5157287", "l": "CD126 blasts | Bone marrow | Cell markers", "d": [], "t": []}], "preferred_name": "CD126 blasts | Bone marrow | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0000534", "l": "primary interneuron (sensu Teleostei)", "d": ["A primary neuron (sensu Teleostei) that is neither a sensory neuron or a motor neuron."], "t": []}], "preferred_name": "primary interneuron (sensu Teleostei)", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1514716", "l": "Raji Cell", "d": [], "t": []}, {"i": "NCIT:C36741", "l": "Raji Cell", "d": [], "t": []}], "preferred_name": "Raji Cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1267904", "l": "Lymphocyte positive for CD31 antigen", "d": [], "t": []}, {"i": "SNOMEDCT:117575006", "l": "", "d": [], "t": []}], "preferred_name": "Lymphocyte positive for CD31 antigen", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0682522", "l": "AGMK cell", "d": [], "t": []}], "preferred_name": "AGMK cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0002571", "l": "hepatic mesenchymal stem cell", "d": ["A mesenchymal stem cell of liver."], "t": []}], "preferred_name": "hepatic mesenchymal stem cell", "taxa": []}
{"type": "biolink:Cell", "ic": 92.76600187037766, "identifiers": [{"i": "CL:4052050", "l": "luminal epithelial cell of endometrium", "d": ["An epithelial cell that is part of an endometrium luminal epithelium."], "t": []}], "preferred_name": "luminal epithelial cell of endometrium", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0314595", "l": "Colony-forming unit of neutrophilic-monocytic lineage", "d": [], "t": []}, {"i": "SNOMEDCT:445287005", "l": "", "d": [], "t": []}], "preferred_name": "Colony-forming unit of neutrophilic-monocytic lineage", "taxa": []}
{"type": "biolink:Cell", "ic": 67.7493467736566, "identifiers": [{"i": "UMLS:C0019612", "l": "Histiocytes", "d": [], "t": []}, {"i": "NCIT:C12563", "l": "Histiocyte", "d": ["A macrophage present in connective tissue."], "t": []}, {"i": "MESH:D006644", "l": "Histiocytes", "d": [], "t": []}, {"i": "SNOMEDCT:14295007", "l": "", "d": [], "t": []}], "preferred_name": "Histiocytes", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1511463", "l": "CY12", "d": [], "t": []}, {"i": "NCIT:C20237", "l": "CY12", "d": ["Provider: CyThera, Inc., San Diego, CA. No information from provider. This cell line meets the criteria for the use of human embryonic stem cells by federally funded researchers."], "t": []}], "preferred_name": "CY12", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0017004", "l": "telocyte", "d": ["A supportive cell with a small, oval-shaped body and one to five telopodes. Telopodes are cytoplasmic protrusions from tens to hundreds of micrometers long and mostly below 0.2 microns of caliber."], "t": []}, {"i": "UMLS:C2717913", "l": "Telocytes", "d": [], "t": []}, {"i": "MESH:D000067170", "l": "Telocytes", "d": [], "t": []}], "preferred_name": "telocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 87.18682603146104, "identifiers": [{"i": "CL:0002003", "l": "CD34-positive, GlyA-negative erythroid progenitor cell", "d": ["An erythroid progenitor cell that is CD34-positive and is GlyA-negative."], "t": []}, {"i": "UMLS:C2350175", "l": "Erythroid Progenitor Cells", "d": [], "t": []}, {"i": "NCIT:C12526", "l": "Erythroid Stem Cell", "d": ["A unipotent hematopoietic progenitor cell derived from myeloid stem cells that is committed to the erythrocyte cell lineage."], "t": []}], "preferred_name": "CD34-positive, GlyA-negative erythroid progenitor cell", "taxa": []}
{"type": "biolink:Cell", "ic": 75.08236434612573, "identifiers": [{"i": "UMLS:C1706725", "l": "Adrenal Cortical Cell", "d": [], "t": []}, {"i": "NCIT:C48358", "l": "Adrenal Cortical Cell", "d": ["An endocrine glandular cell located on the surface of the adrenal gland (adrenal cortex). It is responsible for the synthesis of glucocorticoids, aldosterone, and androgens."], "t": []}], "preferred_name": "Adrenal Cortical Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 73.49439205968403, "identifiers": [{"i": "UMLS:C1514010", "l": "Neoplastic Lobular Epithelial Cell", "d": [], "t": []}, {"i": "NCIT:C36878", "l": "Neoplastic Lobular Epithelial Cell", "d": [], "t": []}], "preferred_name": "Neoplastic Lobular Epithelial Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 92.76600187037766, "identifiers": [{"i": "CL:0002018", "l": "CD71-negative, GlyA-positive orthochromatic erythroblast", "d": ["An erythroblast that is GlyA-positive and CD71-negative."], "t": []}], "preferred_name": "CD71-negative, GlyA-positive orthochromatic erythroblast", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5707731", "l": "Autologous Anti-CLDN6 CAR-NK Cells", "d": [], "t": []}, {"i": "NCIT:C188377", "l": "Autologous Anti-CLDN6 CAR-NK Cells", "d": ["A preparation of autologous natural killer (NK) cells engineered to express a chimeric antigen receptor (CAR) specific for the cell surface protein claudin 6 (CLDN6), with potential immunostimulating and antineoplastic activities. Upon administration, the autologous anti-CLDN6 CAR-NK cells target and bind to CLDN6 expressed on the surface of tumor cells. This induces selective toxicity in tumor cells expressing CLDN6. CLDN6, a tight-junction protein and embryonic antigen, is expressed on a variety of tumor cells but is not expressed on normal, healthy adult cells."], "t": []}], "preferred_name": "Autologous Anti-CLDN6 CAR-NK Cells", "taxa": []}
{"type": "biolink:Cell", "ic": 88.20185721311867, "identifiers": [{"i": "UMLS:C1881551", "l": "Malignant Epithelial Oval Cell", "d": [], "t": []}, {"i": "NCIT:C60991", "l": "Malignant Epithelial Oval Cell", "d": [], "t": []}], "preferred_name": "Malignant Epithelial Oval Cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5571707", "l": "Erythrocytes.ghost cells|Urine/Urine sed", "d": [], "t": []}], "preferred_name": "Erythrocytes.ghost cells|Urine/Urine sed", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0933800", "l": "Microvillus columnar cell", "d": [], "t": []}], "preferred_name": "Microvillus columnar cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5157333", "l": "CD16C+CD56+ cells | Blood | Cell markers", "d": [], "t": []}], "preferred_name": "CD16C+CD56+ cells | Blood | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1277042", "l": "Parathyroid cell", "d": [], "t": []}, {"i": "SNOMEDCT:360553006", "l": "", "d": [], "t": []}], "preferred_name": "Parathyroid cell", "taxa": []}
{"type": "biolink:Cell", "ic": 90.871710685482, "identifiers": [{"i": "UMLS:C1513709", "l": "Mucin-Producing Adenocarcinoma Cell", "d": [], "t": []}, {"i": "NCIT:C36856", "l": "Mucin-Producing Adenocarcinoma Cell", "d": [], "t": []}], "preferred_name": "Mucin-Producing Adenocarcinoma Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5555146", "l": "Autologous Anti-CD19 CAR-T Cells GC019F", "d": [], "t": []}, {"i": "NCIT:C178588", "l": "Autologous Anti-CD19 CAR-T Cells GC019F", "d": ["A preparation of autologous T-lymphocytes that have been genetically modified to express a chimeric antigen receptor (CAR) specific for the tumor-associated antigen (TAA) CD19, with potential immunostimulating and antineoplastic activities. Upon administration, autologous anti-CD19 CAR-T cells GC019F target and bind to CD19-expressing tumor cells. This results in a cytotoxic T-lymphocyte (CTL) response against CD19-expressing tumor cells, the release of cytotoxic molecules and the induction of tumor cell lysis. CD19, cluster of differentiation 19, is a B-cell-specific cell surface antigen overexpressed in B-cell lineage tumors. The processing platform used, FasTCAR, shortens the manufacturing time to produce the CAR-T cells."], "t": []}], "preferred_name": "Autologous Anti-CD19 CAR-T Cells GC019F", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4079027", "l": "sacral dorsal root ganglion substance P neuron", "d": ["A peptidergic nociceptor whose soma is located in the sacral dorsal root ganglion and that expresses substance P, an 11-amino-acid neuropeptide cleaved from protachykinin-1 (encoded by TAC1). This small-diameter neuron frequently co-expresses CGRP and belongs to the TrkA-positive peptidergic population. Upon nociceptive activation, it releases substance P both centrally in the spinal cord dorsal horn and peripherally at sensory nerve terminals, mediating neurogenic inflammation through NK1 receptor signalling (Haberberger et al. 2019, PMID:31293388). Substance P-immunoreactive neurons have been consistently identified in human DRG by immunohistochemistry across multiple studies."], "t": []}], "preferred_name": "sacral dorsal root ganglion substance P neuron", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C2919236", "l": "Colony-forming unit of granulocytic-monocytic lineage (cell)", "d": [], "t": []}, {"i": "SNOMEDCT:445259001", "l": "", "d": [], "t": []}], "preferred_name": "Colony-forming unit of granulocytic-monocytic lineage (cell)", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C6049675", "l": "Prulacabtagene Leucel", "d": [], "t": []}], "preferred_name": "Prulacabtagene Leucel", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C3641004", "l": "Apoptotic Autologous Tumor Cells-pulsed Alpha-type-1 Polarized Dendritic Cells", "d": [], "t": []}, {"i": "NCIT:C102978", "l": "Apoptotic Autologous Tumor Cells-pulsed Alpha-type-1 Polarized Dendritic Cells", "d": ["A cell based cancer vaccine composed of mature polarized dendritic cells (DCs) and pulsed with apoptotic autologous tumor cells that has potential immunostimulating and antineoplatic activities. Dendritic cells (DCs) were treated with interleukin-1beta, tumor necrosis factor alpha, interferon-alpha (IFN-a), IFN-gamma and polyinosinic:polycytidylic acid (p-I:C) to produce mature alpha type-1 polarized DCs (alphaDC1) that are capable of producing high levels of interleukin-12p70 (IL-12p70). The alphaDC1 are subsequently pulsed with apoptotic autologous tumor cells. Upon administration, these DCs are able to induce a potent cytotoxic T lymphocyte (CTL) response against tumor associated antigens (TAAs), resulting in tumor cell lysis and inhibition of tumor cell growth. Apoptotic tumor cells contain an array of TAAs."], "t": []}], "preferred_name": "Apoptotic Autologous Tumor Cells-pulsed Alpha-type-1 Polarized Dendritic Cells", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0546503", "l": "P.B. hemocytoblast", "d": [], "t": []}], "preferred_name": "P.B. hemocytoblast", "taxa": []}
{"type": "biolink:Cell", "ic": 80.96785908349635, "identifiers": [{"i": "CL:1000488", "l": "cholangiocyte", "d": ["An epithelial cell that is part of the bile duct. Cholangiocytes contribute to bile secretion via net release of bicarbonate and water. They are cuboidal epithelium in the small interlobular bile ducts, but become columnar and mucus secreting in larger bile ducts approaching the porta hepatis and the extrahepatic ducts."], "t": []}, {"i": "UMLS:C2323993", "l": "Epithelial cell of bile duct", "d": [], "t": []}], "preferred_name": "cholangiocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 83.63771255585968, "identifiers": [{"i": "CL:0000799", "l": "immature gamma-delta T cell", "d": ["A gamma-delta T cell that has an immature phenotype."], "t": []}], "preferred_name": "immature gamma-delta T cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5834110", "l": "Viralym-C", "d": [], "t": []}], "preferred_name": "Viralym-C", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5401663", "l": "ORBCEL C™", "d": [], "t": []}], "preferred_name": "ORBCEL C™", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:1001572", "l": "colon endothelial cell", "d": ["A vascular endothelial cell found in colon blood vessels."], "t": []}], "preferred_name": "colon endothelial cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5157361", "l": "CD19+Lambda+ cells | Blood | Cell markers", "d": [], "t": []}], "preferred_name": "CD19+Lambda+ cells | Blood | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5783847", "l": "Manufactured Autologous Anti-BCMA CAR-T Cells", "d": [], "t": []}, {"i": "NCIT:C190666", "l": "Manufactured Autologous Anti-BCMA CAR-T Cells", "d": ["A preparation of autologous T-lymphocytes that have been modified to express a chimeric antigen receptor (CAR) targeting the human tumor-associated antigen (TAA) B-cell maturation antigen (BCMA; tumor necrosis factor receptor superfamily member 17; TNFRSF17), with potential immunostimulating and antineoplastic activities. Upon administration, the manufactured autologous anti-BCMA CAR-T cells specifically recognize and induce selective toxicity in BCMA-expressing tumor cells. BCMA, a receptor for both a proliferation-inducing ligand (APRIL) and B-cell activating factor (BAFF), is a member of the tumor necrosis factor receptor superfamily (TNFRSF). BCMA is found on the surfaces of plasma cells, is overexpressed on malignant plasma cells and plays a key role in plasma cell proliferation and survival."], "t": []}], "preferred_name": "Manufactured Autologous Anti-BCMA CAR-T Cells", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1440364", "l": "Cells.CD87", "d": [], "t": []}], "preferred_name": "Cells.CD87", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5238365", "l": "Autologous Peripheral Blood Lymphocytes from Ibrutinib-treated Chronic Lymphocytic Leukemia Patients IOV-2001", "d": [], "t": []}, {"i": "NCIT:C167208", "l": "Autologous Peripheral Blood Lymphocytes from Ibrutinib-treated Chronic Lymphocytic Leukemia Patients IOV-2001", "d": ["A preparation of autologous peripheral blood lymphocytes (PBLs) harvested from chronic lymphocytic leukemia (CLL) patients previously treated with the Brutons' tyrosine kinase (BTK) inhibitor ibrutinib with potential immunostimulating and antineoplastic activities. Upon intravenous administration, IOV-2001 generates an enhanced cytotoxic T-cell response against autologous leukemic B-cells in patients who have relapsed during treatment with ibrutinib. IOV-2001 is mostly comprised of T-cells of which the majority are of the effector memory phenotype which augments the specificity of the immune response."], "t": []}], "preferred_name": "Autologous Peripheral Blood Lymphocytes from Ibrutinib-treated Chronic Lymphocytic Leukemia Patients IOV-2001", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C4085961", "l": "Anti-CD133-CAR Vector-transduced Allogeneic T Lymphocytes", "d": [], "t": []}, {"i": "NCIT:C124132", "l": "Anti-CD133-CAR Vector-transduced Allogeneic T Lymphocytes", "d": ["A preparation of allogeneic peripheral blood T-lymphocytes (PBTL) that have been genetically modified to express a chimeric antigen receptor (CAR) specific for the chimeric CD (cluster of differentiation) 133 antigen receptor, with potential immunostimulating and antineoplastic activities. Upon administration, anti-CD133-CAR vector-transduced allogeneic T-lymphocytes specifically recognize and kill CD133-expressing tumor cells. CD133, a tumor associated antigen (TAA), is overexpressed on a variety of tumor cell types."], "t": []}], "preferred_name": "Anti-CD133-CAR Vector-transduced Allogeneic T Lymphocytes", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4072015", "l": "monocyte-derived Kupffer cell", "d": ["A Kupffer cell located within the hepatic sinusoids, derived from circulating bone marrow monocytes that acquire the phenotypic markers and functional properties of resident Kupffer cells through niche-dependent imprinting, typically following depletion of the embryonically derived Kupffer cell population. During liver injury, MoKCs become the dominant Kupffer cell subset, exhibiting enhanced proliferation, resistance to apoptosis, and key roles in tissue repair and fibrosis attenuation."], "t": []}], "preferred_name": "monocyte-derived Kupffer cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4030014", "l": "kidney loop of Henle long descending thin limb inner medulla epithelial cell", "d": ["Epithelial cell of the descending thin limb of the long loop (juxtamedullary) nephron that spans the inner medulla. It is known in some mammalian species that the long descending limb of the loop of Henle in the inner medulla selectively expresses the nuclear receptor Nr2e3, the Ig kappa chain Igkc, and the secreted protein dermokine (Dmkn). SLC14A2, which expresses a urea transporter, is also expressed in the inner medulla."], "t": []}], "preferred_name": "kidney loop of Henle long descending thin limb inner medulla epithelial cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1514739", "l": "Reactive mesothelial cells", "d": [], "t": []}, {"i": "NCIT:C36830", "l": "Reactive Mesothelial Cell", "d": [], "t": []}, {"i": "SNOMEDCT:447003004", "l": "", "d": [], "t": []}], "preferred_name": "Reactive mesothelial cells", "taxa": []}
{"type": "biolink:Cell", "ic": 84.83823963392128, "identifiers": [{"i": "CL:0002231", "l": "epithelial cell of prostate", "d": ["An epithelial cell of the prostate."], "t": []}, {"i": "UMLS:C1179830", "l": "Epithelial cell of prostate", "d": [], "t": []}], "preferred_name": "epithelial cell of prostate", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0020024", "l": "alpha retinal ganglion cell OFF-sustained (Mmus)", "d": ["A mouse retinal ganglion cell type defined by a large soma and a wide, monostratified dendritic arbor that stratifies just distal to the outer ChAT band of the inner plexiform layer (Krieger et al., 2017). It corresponds to the G5 physiological type (Baden et al., 2016; Goetz et al., 2022) and the C42 transcriptomic cluster (Tran et al., 2019), and is considered the evolutionary ortholog of the primate OFF midget RGC (Hahn et al., 2023). The cell projects a thick, fast-conducting axon to the dorsal lateral geniculate nucleus and superior colliculus. It shows a sustained increase in firing to light decrements with a slow decay time constant of roughly 250 ms and a large receptive field center with weak surround antagonism (Krieger et al., 2017). Its molecular profile includes expression of Spp1 and Neurofilament (Smi32) together with Brn3a (Pou4f1) and Brn3b (Pou4f2), absence of Brn3c (Pou4f3) and Calbindin (Calb1), and strong enrichment of Fes (Krieger et al., 2017; Tran et al., 2019)."], "t": []}], "preferred_name": "alpha retinal ganglion cell OFF-sustained (Mmus)", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5180818", "l": "Sezary cells | XXX | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Sezary cells | XXX | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1440141", "l": "Blasts.CD13", "d": [], "t": []}], "preferred_name": "Blasts.CD13", "taxa": []}
{"type": "biolink:Cell", "ic": 56.52414509155932, "identifiers": [{"i": "CL:0008002", "l": "skeletal muscle fiber", "d": ["A transversely striated, synctial cell of skeletal muscle. It is formed when proliferating myoblasts exit the cell cycle, differentiate and fuse."], "t": []}], "preferred_name": "skeletal muscle fiber", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5216246", "l": "Lymphocytes.plasmacytoid|NCnc|Pt|Bld", "d": [], "t": []}], "preferred_name": "Lymphocytes.plasmacytoid|NCnc|Pt|Bld", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "MESH:D013171", "l": "Spores, Bacterial", "d": [], "t": []}], "preferred_name": "Spores, Bacterial", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1267850", "l": "Lymphocyte positive for CD6 antigen", "d": [], "t": []}, {"i": "SNOMEDCT:117536002", "l": "", "d": [], "t": []}], "preferred_name": "Lymphocyte positive for CD6 antigen", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5216228", "l": "Leukocytes other|NCnc|Pt|Plr fld", "d": [], "t": []}], "preferred_name": "Leukocytes other|NCnc|Pt|Plr fld", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5787280", "l": "Allocetra-OTS", "d": [], "t": []}], "preferred_name": "Allocetra-OTS", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5833237", "l": "Circulating tumor cells | Plasma or Blood | Chemistry - non-challenge", "d": [], "t": []}], "preferred_name": "Circulating tumor cells | Plasma or Blood | Chemistry - non-challenge", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C2327527", "l": "Sympathetic ganglion neuron", "d": [], "t": []}], "preferred_name": "Sympathetic ganglion neuron", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5569916", "l": "Transitional cells.deep", "d": [], "t": []}], "preferred_name": "Transitional cells.deep", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0002358", "l": "pyrenocyte", "d": ["Derived from the Greek word pyren (the pit of a stone fruit), this is a transient nucleated cell type that results from exclusion of the nucleus from the primitive erythrocyte."], "t": []}], "preferred_name": "pyrenocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 62.92033511969085, "identifiers": [{"i": "UMLS:C1518222", "l": "Malignant Neuroendocrine Small Cell", "d": [], "t": []}, {"i": "NCIT:C36820", "l": "Malignant Neuroendocrine Small Cell", "d": [], "t": []}], "preferred_name": "Malignant Neuroendocrine Small Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4030006", "l": "fallopian tube secretory epithelial cell", "d": ["An epithelial cell that is part of the fallopian tube that secretes mucus and oviduct-specific products in response to hormonal stimulation from estrogen and luteinizing hormone. This fallopian tube secretory cell is similar in height to the ciliated cell, but typically exhibits a more narrow, columnar shape. Its nucleus is ovoid and oriented perpendicular to the cell's long axis, with denser chromatin and a smaller nucleolus compared to the ciliated cell."], "t": []}], "preferred_name": "fallopian tube secretory epithelial cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:1000397", "l": "endothelial cell of venous sinus of red pulp of spleen", "d": ["An endothelial cell that is part of the venous sinus of red pulp of spleen."], "t": []}, {"i": "UMLS:C1179416", "l": "Endothelial cell of venous sinus of red pulp of spleen", "d": [], "t": []}], "preferred_name": "endothelial cell of venous sinus of red pulp of spleen", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C2324639", "l": "Retinal glial cell", "d": [], "t": []}], "preferred_name": "Retinal glial cell", "taxa": []}
{"type": "biolink:Cell", "ic": 92.76600187037766, "identifiers": [{"i": "CL:1000239", "l": "anterior lateral line nerve glial cell", "d": ["Any glial cell that is part of some anterior lateral line nerve."], "t": []}], "preferred_name": "anterior lateral line nerve glial cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C2953150", "l": "Type D enteroendocrine cell of epithelium of principal gastric gland", "d": [], "t": []}], "preferred_name": "Type D enteroendocrine cell of epithelium of principal gastric gland", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5980275", "l": "REMESTEMCEL", "d": [], "t": []}], "preferred_name": "REMESTEMCEL", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5827886", "l": "Lantidra", "d": [], "t": []}], "preferred_name": "Lantidra", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "CL:1000383", "l": "type 2 vestibular sensory cell of epithelium of macula of utricle of membranous labyrinth", "d": ["A type II vestibular sensory cell that is part of the epithelium of macula of utricle of membranous labyrinth."], "t": []}, {"i": "UMLS:C2336824", "l": "Type 2 vestibular sensory cell of epithelium of macula of utricle of membranous labyrinth", "d": [], "t": []}], "preferred_name": "type 2 vestibular sensory cell of epithelium of macula of utricle of membranous labyrinth", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C2340140", "l": "Type F enteroendocrine cell", "d": [], "t": []}], "preferred_name": "Type F enteroendocrine cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1267910", "l": "Lymphocyte positive for CD34 antigen", "d": [], "t": []}, {"i": "SNOMEDCT:116733003", "l": "", "d": [], "t": []}], "preferred_name": "Lymphocyte positive for CD34 antigen", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5171656", "l": "Lymphocytes | Blood | Cell markers", "d": [], "t": []}], "preferred_name": "Lymphocytes | Blood | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0000951", "l": "IgE short lived plasma cell", "d": ["A short lived plasma cell that secretes IgE."], "t": []}], "preferred_name": "IgE short lived plasma cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5545271", "l": "Tissue Resident Memory T Cells", "d": [], "t": []}], "preferred_name": "Tissue Resident Memory T Cells", "taxa": []}
{"type": "biolink:Cell", "ic": 71.74874531021723, "identifiers": [{"i": "UMLS:C1704336", "l": "Skeletal Myocytes", "d": [], "t": []}, {"i": "NCIT:C13000", "l": "Rhabdomyocyte", "d": ["A large cylindrical- or prismatic-shaped cell that is the basic unit of striated muscle tissue."], "t": []}, {"i": "NCIT:C33558", "l": "Skeletal Fiber", "d": ["A long, cylindrical, multinucleated cell comprising a network of myofibrils, which contain several proteins that compose the contractile unit of skeletal muscle, of which there are three basic types: intermediate, red, and white."], "t": []}, {"i": "NCIT:C48687", "l": "Skeletal Muscle Cell", "d": [], "t": []}, {"i": "MESH:D018485", "l": "Muscle Fibers, Skeletal", "d": [], "t": []}, {"i": "SNOMEDCT:80985008", "l": "", "d": [], "t": []}], "preferred_name": "Skeletal Myocytes", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0945927", "l": "CD3+HLA-DR+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:1373104007", "l": "", "d": [], "t": []}], "preferred_name": "CD3+HLA-DR+ cell", "taxa": []}
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{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5985059", "l": "Monocytic Myeloid-Derived Suppressor Cell", "d": [], "t": []}, {"i": "NCIT:C213650", "l": "Monocytic Myeloid-Derived Suppressor Cell", "d": ["A population of immature mononuclear phagocytic myeloid cells that are pathologically activated, specifically suppress T-cell immunity and potentially have tumor promoting activities."], "t": []}], "preferred_name": "Monocytic Myeloid-Derived Suppressor Cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5170008", "l": "Kappa lymphocytes | Blood | Cell markers", "d": [], "t": []}], "preferred_name": "Kappa lymphocytes | Blood | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4033112", "l": "middle cervical ganglion VIP neuron", "d": ["A sympathetic neuron that has the soma located in the middle cervical ganglion and expresses the marker vasoactive intestinal peptide (VIP)."], "t": []}], "preferred_name": "middle cervical ganglion VIP neuron", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5908064", "l": "Autologous GCC-targeting CAR T-cells LCAR-G08", "d": [], "t": []}, {"i": "NCIT:C204807", "l": "Autologous GCC-targeting CAR T-cells LCAR-G08", "d": ["A preparation of autologous T-lymphocytes that are genetically engineered, using a lentiviral vector, to express a chimeric antigen receptor (CAR) targeting the enterocyte differentiation antigen guanylyl cyclase C (GUCY2C), with potential immunostimulating and antineoplastic activities. Upon intravenous administration, the autologous GCC-targeting CAR T-cells LCAR-G08 are directed to, specifically bind to, activate, proliferate and release cytokines that promote killing of GCC-expressing tumor cells. GCC is overexpressed in various tumor cell types."], "t": []}], "preferred_name": "Autologous GCC-targeting CAR T-cells LCAR-G08", "taxa": []}
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{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5157275", "l": "CD11c-CD20+ cells | Blood | Cell markers", "d": [], "t": []}], "preferred_name": "CD11c-CD20+ cells | Blood | Cell markers", "taxa": []}
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{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4030009", "l": "epithelial cell of proximal tubule segment 1", "d": ["A brush border cell that is part of segment 1 (S1) of the proximal tubule epithelium, located in the renal cortex."], "t": []}], "preferred_name": "epithelial cell of proximal tubule segment 1", "taxa": []}
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{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5177622", "l": "Platelets | Plasma | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Platelets | Plasma | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0002498", "l": "secondary trophoblast giant cell", "d": ["A trophoblast giant cell that is derived from ectoplacental cone and, later in gestation, the spongiotrophoblast."], "t": []}], "preferred_name": "secondary trophoblast giant cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5163716", "l": "Erythrocytes | Duodenal fluid | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Erythrocytes | Duodenal fluid | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": 79.35380886648232, "identifiers": [{"i": "UMLS:C1711299", "l": "Malignant Epithelioid Endothelial Cell", "d": [], "t": []}, {"i": "NCIT:C53404", "l": "Malignant Epithelioid Endothelial Cell", "d": [], "t": []}], "preferred_name": "Malignant Epithelioid Endothelial Cell", "taxa": []}
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{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5157493", "l": "CD34 cells | Blood | Cell markers", "d": [], "t": []}], "preferred_name": "CD34 cells | Blood | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": 90.871710685482, "identifiers": [{"i": "UMLS:C1513991", "l": "Neoplastic Interdigitating Dendritic Cell", "d": [], "t": []}, {"i": "NCIT:C36892", "l": "Neoplastic Interdigitating Dendritic Cell", "d": [], "t": []}], "preferred_name": "Neoplastic Interdigitating Dendritic Cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4512353", "l": "Entire secondary sclerotic mastoid cell", "d": [], "t": []}, {"i": "SNOMEDCT:727109004", "l": "", "d": [], "t": []}], "preferred_name": "Entire secondary sclerotic mastoid cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0000528", "l": "nitrergic neuron", "d": ["A nerve cell where transmission is mediated by nitric oxide."], "t": []}], "preferred_name": "nitrergic neuron", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C2952434", "l": "Interdigitating dendritic cell of splenic white pulp", "d": [], "t": []}], "preferred_name": "Interdigitating dendritic cell of splenic white pulp", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5446540", "l": "Lymphodepleted Autologous CD4-directed CAR T Cells", "d": [], "t": []}, {"i": "NCIT:C175459", "l": "Lymphodepleted Autologous CD4-directed CAR T Cells", "d": ["A preparation of autologous peripheral blood T-lymphocytes (PBTLs) that have been genetically modified to express a chimeric antigen receptor (CAR) specific for the T-cell surface antigen CD4, administered with lymphodepletion, with potential immunostimulating and antineoplastic activities. Upon administration, lymphodepleted autologous CD4-directed CAR T cells specifically recognize and kill CD4-expressing tumor cells. CD4, a tumor-associated antigen (TAA), is overexpressed in various lymphomas, including peripheral T-cell lymphoma, angioimmunoblastic T-cell lymphoma and anaplastic large cell lymphoma."], "t": []}], "preferred_name": "Lymphodepleted Autologous CD4-directed CAR T Cells", "taxa": []}
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{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0947287", "l": "CD16+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:1372854005", "l": "", "d": [], "t": []}], "preferred_name": "CD16+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5176574", "l": "Pencil cells | Blood | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Pencil cells | Blood | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": 85.53200374075534, "identifiers": [{"i": "CL:0000913", "l": "effector memory CD8-positive, alpha-beta T cell", "d": ["CD8-positive, alpha-beta memory T cell with the phenotype CCR7-negative, CD127-positive, CD45RA-negative, CD45RO-positive, and CD25-negative."], "t": []}], "preferred_name": "effector memory CD8-positive, alpha-beta T cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C3166352", "l": "Spermatozoa.abnormal head shape", "d": [], "t": []}], "preferred_name": "Spermatozoa.abnormal head shape", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5688427", "l": "Population of all cells positive for estrogen receptor in portion of fluid", "d": [], "t": []}, {"i": "SNOMEDCT:1222875003", "l": "", "d": [], "t": []}], "preferred_name": "Population of all cells positive for estrogen receptor in portion of fluid", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0003011", "l": "G8 retinal ganglion cell", "d": ["A mono-stratified retinal ganglion cell that has a large dendritic field and a sparse dendritic arbor with post synaptic terminals in sublaminar layer S4."], "t": []}], "preferred_name": "G8 retinal ganglion cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C6056203", "l": "Allogenic Chimeric Antigen Receptor T Cells Targeting B Cell Maturation Antigen (BCMA)", "d": [], "t": []}], "preferred_name": "Allogenic Chimeric Antigen Receptor T Cells Targeting B Cell Maturation Antigen (BCMA)", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5984945", "l": "Autologous Anti-FLT3 CAR-T Cells HG-CT-1", "d": [], "t": []}], "preferred_name": "Autologous Anti-FLT3 CAR-T Cells HG-CT-1", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C3827836", "l": "TGFbDNRII-transduced Autologous Tumor Infiltrating Lymphocytes", "d": [], "t": []}, {"i": "NCIT:C111992", "l": "TGFbDNRII-transduced Autologous Tumor Infiltrating Lymphocytes", "d": ["A preparation of tumor infiltrating lymphocytes (TILs) that are transduced with a retroviral vector encoding a gene for a dominant-negative form of the transforming growth factor beta (TGFb) receptor, TGFbDNRII, with potential immunomodulating activity. Upon administration, the TGFbDNRII-transduced autologous TILs recognize and kill tumor cells. The expression of TGFbDNRII allows for the TILs to be resistant to TGF-b-mediated inhibition of T cell proliferation and activation, which allows optimal TIL activity. The immunosuppressant TGF-b is produced by tumor cells and plays a key role in the repression of the immune system."], "t": []}], "preferred_name": "TGFbDNRII-transduced Autologous Tumor Infiltrating Lymphocytes", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C6051120", "l": "Autologous dNPM1 Peptides-specific HLA-A*02:01-restricted TCR T-lymphocytes MB-dNPM1-TCR.1", "d": [], "t": []}, {"i": "NCIT:C217333", "l": "Autologous dNPM1 Peptides-specific HLA-A*02:01-restricted TCR T-lymphocytes MB-dNPM1-TCR.1", "d": ["A preparation of autologous T-lymphocytes that have been genetically modified using a lentiviral vector to express a T-cell receptor (TCR) specific for certain dNPM1 peptides restricted to human leukocyte antigen (HLA)-A*02:01, with potential antineoplastic activity. Upon isolation, transduction, expansion ex vivo and re-introduction into the patient, the autologous dNPM1 peptides-specific HLA-A*02:01-restricted TCR T-lymphocytes MB-dNPM1-TCR.1 target and bind to the HLA/dNPM1 peptide complex on tumor cells, which leads to the elimination of tumor cells expressing dNPM1. Mutated forms of NPM1 (nucleophosmin 1), a multifunctional chaperone protein, are found on certain tumor cells, including leukemic myeloid cells."], "t": []}], "preferred_name": "Autologous dNPM1 Peptides-specific HLA-A*02:01-restricted TCR T-lymphocytes MB-dNPM1-TCR.1", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1953343", "l": "Chromosome number", "d": [], "t": []}], "preferred_name": "Chromosome number", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:2000079", "l": "mesenchymal stem cell of femoral bone marrow", "d": ["Any mesenchymal stem cell of the bone marrow that is part of a femur."], "t": []}], "preferred_name": "mesenchymal stem cell of femoral bone marrow", "taxa": []}
{"type": "biolink:Cell", "ic": 77.38833137893549, "identifiers": [{"i": "UMLS:C3899033", "l": "Genetically Engineered Hematopoietic Stem Progenitor Cells", "d": [], "t": []}, {"i": "NCIT:C119988", "l": "Genetically Engineered Hematopoietic Stem Progenitor Cells", "d": ["Gene modified hematopoietic stem progenitor cells (HSPCs)."], "t": []}], "preferred_name": "Genetically Engineered Hematopoietic Stem Progenitor Cells", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5216313", "l": "Granulocytes|NCnc|Pt|Synv fld", "d": [], "t": []}], "preferred_name": "Granulocytes|NCnc|Pt|Synv fld", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1267930", "l": "Lymphocyte positive for CD45RA antigen", "d": [], "t": []}, {"i": "SNOMEDCT:117373003", "l": "", "d": [], "t": []}], "preferred_name": "Lymphocyte positive for CD45RA antigen", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5186802", "l": "Macrophages | Fetus | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Macrophages | Fetus | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C2826385", "l": "Umbilical Cord Blood-Derived Mesenchymal Stem Cells", "d": [], "t": []}, {"i": "NCIT:C82688", "l": "Umbilical Cord Blood-Derived Mesenchymal Stem Cells", "d": ["Multipotent stem cells of mesenchymal origin isolated from umbilical cord blood. Umbilical cord blood-derived mesenchymal stem cells can differentiate into a variety of cell types including fibroblasts, osteoblasts, chondrocytes, myocytes, adipocytes, and endothelial cells."], "t": []}], "preferred_name": "Umbilical Cord Blood-Derived Mesenchymal Stem Cells", "taxa": []}
{"type": "biolink:Cell", "ic": 61.26027025795748, "identifiers": [{"i": "CL:0000791", "l": "mature alpha-beta T cell", "d": ["A alpha-beta T cell that has a mature phenotype."], "t": []}], "preferred_name": "mature alpha-beta T cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C6021985", "l": "Leukocytes | Wound deep | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Leukocytes | Wound deep | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": 82.16838616155795, "identifiers": [{"i": "CL:0001063", "l": "neoplastic cell", "d": ["An abnormal cell exhibiting dysregulation of cell proliferation or programmed cell death and capable of forming a neoplasm, an aggregate of cells in the form of a tumor mass or an excess number of abnormal cells (liquid tumor) within an organism."], "t": []}], "preferred_name": "neoplastic cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1514137", "l": "Plant Tissue, Cells", "d": [], "t": []}, {"i": "NCIT:C18945", "l": "Plant Tissue, Cells", "d": ["Tissue and cells derived from plants"], "t": []}], "preferred_name": "Plant Tissue, Cells", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5986006", "l": "Autologous mRNA-transfected Anti-BCMA-CAR T-lymphocytes SYS6020", "d": [], "t": []}, {"i": "NCIT:C215083", "l": "Autologous mRNA-transfected Anti-BCMA-CAR T-lymphocytes SYS6020", "d": ["A preparation consisting of autologous T-lymphocytes that have been transfected with lipid nanoparticle (LNP)-mRNA encoding for a chimeric antigen receptor (CAR) specific for the tumor-associated antigen (TAA) human B-cell maturation antigen (BCMA; tumor necrosis factor receptor superfamily member 17; TNFRSF17) and containing as of yet undisclosed co-stimulatory signaling domains, with potential immunostimulating and antineoplastic activities. Upon administration, autologous mRNA-transfected anti-BCMA-CAR T-lymphocytes SYS6020 specifically recognize and induce selective toxicity in BCMA-expressing tumor cells. BCMA, a tumor-specific antigen and a receptor for both a proliferation-inducing ligand (APRIL) and B-cell activating factor (BAFF), is a member of the tumor necrosis factor receptor superfamily (TNFRSF) and plays a key role in plasma cell survival. BCMA is found on the surfaces of plasma cells and overexpressed on malignant plasma cells."], "t": []}], "preferred_name": "Autologous mRNA-transfected Anti-BCMA-CAR T-lymphocytes SYS6020", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0883467", "l": "CD11+CD20+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:1372959004", "l": "", "d": [], "t": []}], "preferred_name": "CD11+CD20+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5849100", "l": "Tumor Associated Lymphocyte", "d": [], "t": []}, {"i": "NCIT:C200593", "l": "Tumor Associated Lymphocyte", "d": ["A term that refers to non-neoplastic lymphocytes that derive from malignant effusions."], "t": []}], "preferred_name": "Tumor Associated Lymphocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5784823", "l": "AVB-001", "d": [], "t": []}, {"i": "NCIT:C192001", "l": "Allogeneic Polymer-encapsulated IL-2-secreting Retinal Pigmented Epithelial Cells AVB-001", "d": ["A preparation of polymer-encapsulated cells, obtained from the human immortalized retinal pigment epithelia (RPE) cell line ARPE-19, that have been genetically engineered to express the human cytokine interleukin-2 (IL-2; IL2), with potential immunomodulatory and antineoplastic activities. Upon intraperitoneal administration, allogeneic polymer-encapsulated IL-2-secreting RPE cells AVB-001 produces IL-2 locally, which binds to the IL-2 receptor (IL-2R) and activates IL-2/IL-2R-mediated signaling. This activates cytotoxic T-lymphocytes (CTLs) and natural killer (NK) cells and induces expression of certain cytotoxic cytokines, such as interferon-gamma (IFNg) and transforming growth factor-beta (TGFb). This leads to T-cell-mediated cytotoxic immune responses against tumor cells and inhibition of tumor cell proliferation. The local delivery of AVB-001 reduces systemic toxicities, and the polymer encapsulation allows for longer half-life."], "t": []}], "preferred_name": "AVB-001", "taxa": []}
{"type": "biolink:Cell", "ic": 88.20185721311867, "identifiers": [{"i": "CL:0002131", "l": "regular ventricular cardiac myocyte", "d": ["Regular cardiac myocyte of a cardiac ventricle."], "t": []}, {"i": "UMLS:C2339371", "l": "Regular ventricular cardiac myocyte", "d": [], "t": []}], "preferred_name": "regular ventricular cardiac myocyte", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5909009", "l": "Firicabtagene Autoleucel", "d": [], "t": []}], "preferred_name": "Firicabtagene Autoleucel", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C6021826", "l": "Blasts.CD38", "d": [], "t": []}], "preferred_name": "Blasts.CD38", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5690109", "l": "LRBA+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:1373077003", "l": "", "d": [], "t": []}], "preferred_name": "LRBA+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": 88.20185721311867, "identifiers": [{"i": "CL:0000885", "l": "gut-associated lymphoid tissue macrophage", "d": ["A mucosa-associated lymphoid tissue macrophage found in the mucosa-associated lymphoid tissues of the gut."], "t": []}], "preferred_name": "gut-associated lymphoid tissue macrophage", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0002383", "l": "conidium of conidiophore head", "d": ["A uninucleate spore formed on specialized cells or projections, sterigma, of a conidiophore head."], "t": []}], "preferred_name": "conidium of conidiophore head", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4052041", "l": "tuft cell of auditory tube", "d": ["A tuft cell that is part of the epithelium of the pharyngotympanic (auditory) tube. This chemosensory cell is often positioned near cholinoreceptive sensory nerve fibers, suggesting a role in neuroimmune communication. It detects chemical signals and releases neuropeptides, such as acetylcholine (ACh) and CGRP, which contribute to inflammatory responses that help protect deeper tissues from harmful substances."], "t": []}], "preferred_name": "tuft cell of auditory tube", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0002579", "l": "omentum preadipocyte", "d": ["A preadipocyte that is part of an omentum."], "t": []}], "preferred_name": "omentum preadipocyte", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5177626", "l": "Platelets Large | Blood | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Platelets Large | Blood | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": 69.67647926784257, "identifiers": [{"i": "UMLS:C1514030", "l": "Neoplastic Multinucleated Giant Cell", "d": [], "t": []}, {"i": "NCIT:C36819", "l": "Neoplastic Multinucleated Giant Cell", "d": ["A benign or malignant neoplastic large cell that contains multiple nuclei and an abundant amount of cytoplasm."], "t": []}], "preferred_name": "Neoplastic Multinucleated Giant Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4307109", "l": "OEC NN_1 Adamts12 olfactory ensheathing cell (Mmus)", "d": ["A olfactory ensheathing cell of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Cldn5 (Mmus), Adamts12 (Mmus). It is distinguished from other OEC cells by expression of Adamts12. These cells are located in the brain , in or close to the regions: olfactory nerve layer of main olfactory bulb . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5289 OEC NN_1."], "t": []}], "preferred_name": "OEC NN_1 Adamts12 olfactory ensheathing cell (Mmus)", "taxa": []}
{"type": "biolink:Cell", "ic": 92.76600187037766, "identifiers": [{"i": "CL:0000567", "l": "polymodal nocireceptor", "d": [], "t": []}], "preferred_name": "polymodal nocireceptor", "taxa": []}
{"type": "biolink:Cell", "ic": 85.53200374075534, "identifiers": [{"i": "UMLS:C1455888", "l": "Atypical Glandular Cell", "d": [], "t": []}, {"i": "NCIT:C36912", "l": "Atypical Glandular Cell", "d": ["An abnormal endocervical or endometrial cell found in a cervical smear, not further characterized as neoplastic or non-neoplastic. It is often associated with clinically significant uterine lesions."], "t": []}], "preferred_name": "Atypical Glandular Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5420487", "l": "TM4SF1-CAR/EpCAM-CAR-expressing Autologous T Cells", "d": [], "t": []}, {"i": "NCIT:C173965", "l": "TM4SF1-CAR/EpCAM-CAR-expressing Autologous T Cells", "d": ["A mixed preparation of allogeneic T-lymphocytes that have been genetically modified to express either a chimeric antigen receptor (CAR) specific for the antigen transmembrane 4 L six family member 1 (TM4SF1) (CART-TM4SF1) or a CAR specific for epithelial cell adhesion molecule (EpCAM) (CART-EpCAM), with potential immunostimulating and antineoplastic activities. Upon administration of the TM4SF1-CAR/EpCAM-CAR-expressing autologous T cells, the TM4SF1-CAR-expressing autologous T-cells specifically recognize and bind to TM4SF1-expressing tumor cells and the EpCAM-CAR-expressing autologous T-cells specifically recognize and bind to EpCAM-expressing tumor cells, resulting in tumor cell lysis. TM4SF1 and EpCAM are expressed by a variety of tumor cells."], "t": []}], "preferred_name": "TM4SF1-CAR/EpCAM-CAR-expressing Autologous T Cells", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4023163", "l": "spherical bushy cell", "d": ["A bushy cell that receives only few large excitatory endbulb synapses from auditory nerves. Spherical bush cells give excitatory input to the lateral and medial parts of the superior olive."], "t": []}], "preferred_name": "spherical bushy cell", "taxa": []}
{"type": "biolink:Cell", "ic": 81.34422831136257, "identifiers": [{"i": "CL:0002672", "l": "retinal progenitor cell", "d": ["A multi-fate stem cell that can give rise to different retinal cell types including rod and cone cells."], "t": []}], "preferred_name": "retinal progenitor cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4307046", "l": "Astro-TE NN_3 Zic4 astrocyte (Mmus)", "d": ["A astrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of S1pr1 (Mmus), Ranbp3l (Mmus), Emx2os (Mmus), Zic4 (Mmus). It is distinguished from other Astro-TE NN_3 cells by expression of Zic4. These cells are located in the Lateral septal complex, Isocortex, Olfactory areas , in or close to the regions: Lateral septal nucleus, rostral (rostroventral) part . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5226 Astro-TE NN_3."], "t": []}], "preferred_name": "Astro-TE NN_3 Zic4 astrocyte (Mmus)", "taxa": []}
{"type": "biolink:Cell", "ic": 76.04769967783396, "identifiers": [{"i": "UMLS:C1510732", "l": "Abnormal Myoepithelial Cell", "d": [], "t": []}, {"i": "NCIT:C36769", "l": "Abnormal Myoepithelial Cell", "d": [], "t": []}], "preferred_name": "Abnormal Myoepithelial Cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C2951544", "l": "Type D enteroendocrine cell of epithelium proper of jejunum", "d": [], "t": []}], "preferred_name": "Type D enteroendocrine cell of epithelium proper of jejunum", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0483184", "l": "CD16+CD57+", "d": [], "t": []}], "preferred_name": "CD16+CD57+", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5667051", "l": "Autologous Anti-CD79a/anti-CD20 CAR T-cells bbT369", "d": [], "t": []}, {"i": "NCIT:C186367", "l": "Autologous Anti-CD79a/anti-CD20 CAR T-cells bbT369", "d": ["A preparation of genetically modified autologous T-lymphocytes that are transduced with a single lentiviral vector (LVV) to express chimeric antigen receptors (CARs) specific for the two tumor-associated antigens (TAAs) cluster of differentiation 20 (CD20) and the B-cell antigen receptor complex-associated protein alpha chain (CD79a), and transfected with an mRNA encoding the Casitas B-lineage lymphoma proto-oncogene-b (CBLB)-targeting megaTAL enzyme to edit the CBLB gene, with potential immunostimulating and antineoplastic activities. Upon administration, the autologous anti-CD20/CD79a CAR-T cells bbT369 target and bind to CD20- and CD79a-expressing tumor B-cells. This induces selective toxicity in tumor B-cells expressing these TAAs. Both CD20 and CD79a are B-cell-specific cell surface antigens overexpressed in B-cell lineage malignancies. Targeting both CD20 and CD79a may prevent tumor cell antigen escape and relapse, and may increase anti-tumor activity. The removal of CBLB, an E3 ubiquitin ligase and a negative regulator of T-cell function, will increase T-cell expansion and activation."], "t": []}], "preferred_name": "Autologous Anti-CD79a/anti-CD20 CAR T-cells bbT369", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C3899816", "l": "CD28CAR/CD137CAR-expressing T-Lymphocytes", "d": [], "t": []}, {"i": "NCIT:C117232", "l": "CD28CAR/CD137CAR-expressing T-Lymphocytes", "d": ["Third generation, chimeric antigen receptor (CAR) cells composed of T-lymphocytes transduced with a lentiviral vector expressing a CAR consisting of an a single chain variable fragment specific for a particular antigen, coupled to the two co-stimulatory signaling domains Cluster of Differentiation 28 (CD28) and Cluster of Differentiation 137 (CD137; 4-1BB), and the zeta chain of the T-cell receptor (TCR)/CD3 complex (CD3-zeta), with potential immunomodulating and antineoplastic activities. Upon transfusion, CD28CAR/CD137CAR-expressing T-lymphocytes are directed to, and induce selective toxicity in tumor cells expressing the particular antigen. CD28, a T-cell surface-associated co-stimulatory molecule, is required for T-cell activation, proliferation, and survival. The 4-1BB co-stimulatory molecule signaling domain enhances activation and signaling after recognition of the antigen. Furthermore, inclusion of the 4-1BB signaling domain may increase the antitumor activity when compared to the inclusion of the CD28 co-stimulatory domain and CD3-zeta alone."], "t": []}], "preferred_name": "CD28CAR/CD137CAR-expressing T-Lymphocytes", "taxa": []}
{"type": "biolink:Cell", "ic": 92.76600187037766, "identifiers": [{"i": "UMLS:C4277548", "l": "Cancer-Associated Fibroblasts", "d": [], "t": []}, {"i": "NCIT:C168534", "l": "Cancer-Associated Fibroblast", "d": ["A fibroblast found proximal to or within cancerous tissue."], "t": []}, {"i": "MESH:D000072645", "l": "Cancer-Associated Fibroblasts", "d": [], "t": []}], "preferred_name": "Cancer-Associated Fibroblasts", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5909011", "l": "Itezocabtagene Autoleucel", "d": [], "t": []}, {"i": "NCIT:C203128", "l": "Itezocabtagene Autoleucel", "d": [], "t": []}], "preferred_name": "Itezocabtagene Autoleucel", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C3850017", "l": "Endothelial Progenitor Cells", "d": [], "t": []}, {"i": "NCIT:C124145", "l": "Endothelial Progenitor Cell", "d": ["Circulating cells that express a variety of cell surface markers similar to those expressed by vascular endothelial cells, adhere to endothelium at sites of hypoxia or ischemia, and participate in new vessel formation."], "t": []}, {"i": "MESH:D066026", "l": "Endothelial Progenitor Cells", "d": [], "t": []}], "preferred_name": "Endothelial Progenitor Cells", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "CL:1000438", "l": "epithelial cell of wall of inferior part of anal canal", "d": ["An epithelial cell that is part of the wall of inferior part of anal canal."], "t": []}, {"i": "UMLS:C1182621", "l": "Epithelial cell of wall of inferior part of anal canal", "d": [], "t": []}], "preferred_name": "epithelial cell of wall of inferior part of anal canal", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0945921", "l": "CD2+CD26+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:1372989006", "l": "", "d": [], "t": []}], "preferred_name": "CD2+CD26+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": 87.18682603146104, "identifiers": [{"i": "UMLS:C1514037", "l": "Neoplastic Myeloblast without Azurophilic Granules", "d": [], "t": []}, {"i": "NCIT:C37179", "l": "Neoplastic Myeloblast without Azurophilic Granules", "d": [], "t": []}], "preferred_name": "Neoplastic Myeloblast without Azurophilic Granules", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C3258047", "l": "Pincer cell", "d": [], "t": []}, {"i": "SNOMEDCT:725267005", "l": "", "d": [], "t": []}], "preferred_name": "Pincer cell", "taxa": []}
{"type": "biolink:Cell", "ic": 80.61184433509295, "identifiers": [{"i": "CL:0002598", "l": "bronchial smooth muscle cell", "d": ["Any smooth muscle cell that is part of some bronchus."], "t": []}], "preferred_name": "bronchial smooth muscle cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4033042", "l": "metallothionein-positive alveolar macrophage", "d": ["An alveolar macrophage that expresses metallothionein."], "t": []}], "preferred_name": "metallothionein-positive alveolar macrophage", "taxa": []}
{"type": "biolink:Cell", "ic": 92.76600187037766, "identifiers": [{"i": "CL:0002051", "l": "CD38-high pre-BCR positive cell", "d": ["A pre-BCR positive B cell that is CD38-high."], "t": []}], "preferred_name": "CD38-high pre-BCR positive cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0002402", "l": "Peyer's patch B cell", "d": ["A resting mature B cell within the Peyer's patch that is CD19-positive, B220-positive, IgM-positive, AA4-negative, CD23-positive, CD43-negative, and CD5-negative."], "t": []}], "preferred_name": "Peyer's patch B cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5157664", "l": "CD8 cells | Blood | Cell markers", "d": [], "t": []}], "preferred_name": "CD8 cells | Blood | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5783903", "l": "Rildinadstrocel", "d": [], "t": []}, {"i": "NCIT:C190749", "l": "Rildinadstrocel", "d": [], "t": []}], "preferred_name": "Rildinadstrocel", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1512137", "l": "ESO-1 Reactive Autologous Peripheral Blood Lymphocyte", "d": [], "t": []}, {"i": "NCIT:C38119", "l": "ESO-1 Reactive Autologous Peripheral Blood Lymphocyte", "d": ["Human peripheral blood lymphocytes (PBL) isolated from a patient, exposed to the tumor-associated protein ESO-1 in vitro, and then transferred back to the same patient to target tumor cells expressing ESO-1. ESO-1 is a human self-antigen expressed by melanomas. The ESO-1 gene encodes several MHC class I- and MHC class II-restricted epitopes that may activate cytotoxic T-cell-mediated tumor destruction. (NCI04)"], "t": []}], "preferred_name": "ESO-1 Reactive Autologous Peripheral Blood Lymphocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4023107", "l": "reticulospinal neuron", "d": ["A neuron with soma location in the reticular formation with axons that extend into the spinal cord such. Reticulospinal neuron activity can lead to a variety of motor behaviors."], "t": []}], "preferred_name": "reticulospinal neuron", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0007017", "l": "Stiftchenzellen", "d": ["An epidermal cell with apical microvilli or a single apical projection have synaptic associations with nerve fibres in the epidermis."], "t": []}], "preferred_name": "Stiftchenzellen", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1979646", "l": "Blasts.CD36+CD235a+", "d": [], "t": []}], "preferred_name": "Blasts.CD36+CD235a+", "taxa": []}
{"type": "biolink:Cell", "ic": 92.76600187037766, "identifiers": [{"i": "CL:0000865", "l": "gastrointestinal tract (lamina propria) macrophage", "d": ["A gut-associated lymphoid tissue macrophage found in lamina propria of the gut."], "t": []}], "preferred_name": "gastrointestinal tract (lamina propria) macrophage", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5178284", "l": "Prolymphocytes | Blood | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Prolymphocytes | Blood | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": 92.76600187037766, "identifiers": [{"i": "CL:0002508", "l": "langerin-negative, CD103-negative lymph node dendritic cell", "d": ["A dermal dendritic cell isolated from skin draining lymph nodes that is langerin-negative, MHC-II-positive, and CD4-negative and CD8a-negative."], "t": []}], "preferred_name": "langerin-negative, CD103-negative lymph node dendritic cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5186823", "l": "Monocytes | Fetus | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Monocytes | Fetus | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4029003", "l": "somatic nurse-like cell", "d": ["A gamete-nursing cell that derives from the somatic tissues of the gonad (del Pino, 2021)."], "t": []}], "preferred_name": "somatic nurse-like cell", "taxa": []}
{"type": "biolink:Cell", "ic": 69.87704306295657, "identifiers": [{"i": "CL:0000128", "l": "oligodendrocyte", "d": ["A class of large neuroglial (macroglial) cells in the central nervous system. Form the insulating myelin sheath of axons in the central nervous system."], "t": []}, {"i": "UMLS:C0028944", "l": "Oligodendroglia", "d": [], "t": []}, {"i": "NCIT:C12618", "l": "Oligodendrocyte", "d": ["A type of large glial cell located in the central nervous system that produces myelin as its main function."], "t": []}, {"i": "MESH:D009836", "l": "Oligodendroglia", "d": [], "t": []}, {"i": "SNOMEDCT:66254009", "l": "", "d": [], "t": []}], "preferred_name": "oligodendrocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "CL:0002115", "l": "B220-positive CD38-positive unswitched memory B cell", "d": ["A B220-positive CD38-positive unswitched memory B cell is a CD38-positive unswitched memory B cell that has the phenotype B220-positive, CD38-positive, IgD-positive, CD138-negative, and IgG-negative."], "t": []}], "preferred_name": "B220-positive CD38-positive unswitched memory B cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C2340053", "l": "Type EC enteroendocrine cell", "d": [], "t": []}], "preferred_name": "Type EC enteroendocrine cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5180574", "l": "Segmented neutrophils | Blood | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Segmented neutrophils | Blood | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0002229", "l": "light chief cell of parathyroid gland", "d": ["A chief cell that is bigger than dark chief cells and has a larger and lighter nucleus and a cytoplasm with few granules."], "t": []}, {"i": "UMLS:C1181297", "l": "Light chief cell of parathyroid gland", "d": [], "t": []}], "preferred_name": "light chief cell of parathyroid gland", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:2000072", "l": "adipose microvascular endothelial cell", "d": ["Any microvascular endothelial cell that is part of a adipose tissue."], "t": []}], "preferred_name": "adipose microvascular endothelial cell", "taxa": []}
{"type": "biolink:Cell", "ic": 83.11065783093733, "identifiers": [{"i": "UMLS:C0221266", "l": "Dacryocyte (cell)", "d": [], "t": []}, {"i": "NCIT:C36726", "l": "Dacrocyte", "d": ["A tear drop shaped erythrocyte, typically associated with primary or secondary myelofibrosis as well as malignant infiltrative disorders of the bone marrow."], "t": []}, {"i": "SNOMEDCT:47787007", "l": "", "d": [], "t": []}], "preferred_name": "Dacryocyte (cell)", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5157491", "l": "CD34 blasts | Bone marrow | Cell markers", "d": [], "t": []}], "preferred_name": "CD34 blasts | Bone marrow | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": 89.40238429118027, "identifiers": [{"i": "CL:0000989", "l": "CD11c-low plasmacytoid dendritic cell", "d": ["CD11c-low plasmacytoid dendritic cell is a leukocyte that is CD11c-low, CD45R-positive, GR1-positive and CD11b-negative."], "t": []}], "preferred_name": "CD11c-low plasmacytoid dendritic cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4518170", "l": "Population of all immature eosinophils in portion of fluid", "d": [], "t": []}, {"i": "SNOMEDCT:725440002", "l": "", "d": [], "t": []}], "preferred_name": "Population of all immature eosinophils in portion of fluid", "taxa": []}
{"type": "biolink:Cell", "ic": 78.54651317367835, "identifiers": [{"i": "CL:0000792", "l": "CD4-positive, CD25-positive, alpha-beta regulatory T cell", "d": ["A CD4-positive, CD25-positive, alpha-beta T cell that regulates overall immune responses as well as the responses of other T cell subsets through direct cell-cell contact and cytokine release."], "t": []}], "preferred_name": "CD4-positive, CD25-positive, alpha-beta regulatory T cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0003044", "l": "M11 retinal ganglion cell", "d": ["A bistratified ganglion cell with small, dense dendritic fields that terminate in S1 and S3."], "t": []}], "preferred_name": "M11 retinal ganglion cell", "taxa": []}
{"type": "biolink:Cell", "ic": 75.2337427109536, "identifiers": [{"i": "UMLS:C1513946", "l": "Neoplastic Cutaneous Basal Cell", "d": [], "t": []}, {"i": "NCIT:C36781", "l": "Neoplastic Cutaneous Basal Cell", "d": [], "t": []}], "preferred_name": "Neoplastic Cutaneous Basal Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1832043", "l": "TALL-104", "d": [], "t": []}, {"i": "NCIT:C66980", "l": "Human MHC Non-Restricted Cytotoxic T-Cell Line TALL-104", "d": ["An allogeneic human cytotoxic T-lymphocyte cell line (TALL-104) with potential antineoplastic activity. TALL-104 is an IL-2-dependent human leukemic T cell line, expressing CD8 and T-cell receptor CD3, but not CD16. Because these cells are endowed with MHC-non-restricted killer activity, TALL-104 has destructive potential against a broad range of tumors, while sparing normal cells. Upon administration, TALL-104 targets and interacts with tumor cells and activates apoptotic and necrotic pathways, eventually leading to lysis of tumor cells. In addition, TALL-104 may induce secretion of various cytokines, such as interferon-gamma, thereby potentially enhancing the cytotoxic activity."], "t": []}], "preferred_name": "TALL-104", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "UMLS:C1518997", "l": "Peripheral Blood Lymphocyte", "d": [], "t": []}, {"i": "NCIT:C12938", "l": "Peripheral Blood Lymphocyte", "d": ["A lymphocyte circulating in the peripheral blood."], "t": []}], "preferred_name": "Peripheral Blood Lymphocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "CL:0000872", "l": "splenic marginal zone macrophage", "d": ["A splenic macrophage found in the marginal zone of the spleen, involved in recognition and clearance of particulate material from the splenic circulation. Markers include F4/80-negative, MARCO-positive, SR-A-positive, SIGN-R1-positive, and Dectin2-positive."], "t": []}], "preferred_name": "splenic marginal zone macrophage", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5173436", "l": "Monocytes | Peritoneal fluid | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Monocytes | Peritoneal fluid | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1879553", "l": "Adenocarcinoma Cell with Abundant Finely Vacuolated Cytoplasm", "d": [], "t": []}, {"i": "NCIT:C54718", "l": "Adenocarcinoma Cell with Abundant Finely Vacuolated Cytoplasm", "d": [], "t": []}], "preferred_name": "Adenocarcinoma Cell with Abundant Finely Vacuolated Cytoplasm", "taxa": []}
{"type": "biolink:Cell", "ic": 76.5892103226413, "identifiers": [{"i": "CL:1001433", "l": "epithelial cell of exocrine pancreas", "d": ["An epithelial cell of the exocrine pancreas."], "t": []}, {"i": "UMLS:C1182803", "l": "Epithelial cell of exocrine pancreas", "d": [], "t": []}], "preferred_name": "epithelial cell of exocrine pancreas", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0002407", "l": "mature Vgamma2-positive thymocyte", "d": ["A thymocyte that has a T cell receptor consisting of a gamma chain containing Vgamma2 segment, and a delta chain. This cell type is CD4-negative, CD8-negative and CD24-negative."], "t": []}], "preferred_name": "mature Vgamma2-positive thymocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C2346933", "l": "Malignant Epithelioid Osteoblast", "d": [], "t": []}, {"i": "NCIT:C67523", "l": "Malignant Epithelioid Osteoblast", "d": [], "t": []}], "preferred_name": "Malignant Epithelioid Osteoblast", "taxa": []}
{"type": "biolink:Cell", "ic": 82.16838616155795, "identifiers": [{"i": "UMLS:C1514088", "l": "Neoplastic Small Immature Neuroepithelial Cell", "d": [], "t": []}, {"i": "NCIT:C41836", "l": "Neoplastic Small Immature Neuroepithelial Cell", "d": [], "t": []}], "preferred_name": "Neoplastic Small Immature Neuroepithelial Cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5556515", "l": "Allogeneic Multi-VSTs ALVR106", "d": [], "t": []}], "preferred_name": "Allogeneic Multi-VSTs ALVR106", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5157436", "l": "CD3+CD4+ (T4 helper) cells | Bone marrow | Cell markers", "d": [], "t": []}], "preferred_name": "CD3+CD4+ (T4 helper) cells | Bone marrow | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1182613", "l": "Epithelial cell of nasal part of viscerocranial mucosa", "d": [], "t": []}], "preferred_name": "Epithelial cell of nasal part of viscerocranial mucosa", "taxa": []}
{"type": "biolink:Cell", "ic": 80.27409497666227, "identifiers": [{"i": "UMLS:C1518846", "l": "Paget Cell", "d": [], "t": []}, {"i": "NCIT:C36754", "l": "Paget Cell", "d": [], "t": []}], "preferred_name": "Paget Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:2000025", "l": "spinal cord oligodendrocyte", "d": ["Any oligodendrocyte that is part of a spinal cord."], "t": []}], "preferred_name": "spinal cord oligodendrocyte", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4300400", "l": "Cells.chromosome region 7q31 deletion", "d": [], "t": []}], "preferred_name": "Cells.chromosome region 7q31 deletion", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5941833", "l": "Tecelra", "d": [], "t": []}], "preferred_name": "Tecelra", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5170927", "l": "Leukocytes | Dialysis fluid peritoneal | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Leukocytes | Dialysis fluid peritoneal | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": 40.38139217448448, "identifiers": [{"i": "CL:0000066", "l": "epithelial cell", "d": ["A cell that is usually found in a two-dimensional sheet with a free surface. The cell has a cytoskeleton that allows for tight cell to cell contact and for cell polarity where apical part is directed towards the lumen and the basal part to the basal lamina."], "t": []}, {"i": "UMLS:C0014597", "l": "Epithelial Cells", "d": [], "t": []}, {"i": "NCIT:C12578", "l": "Epithelial Cell", "d": ["Any of the cells of the epithelium, which covers the body and lines its cavities and glands."], "t": []}, {"i": "MESH:D004847", "l": "Epithelial Cells", "d": [], "t": []}, {"i": "SNOMEDCT:4212006", "l": "", "d": [], "t": []}], "preferred_name": "epithelial cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C4288083", "l": "Type-1 Polarized Dendritic Cell-induced Antigen-specific Autologous Cytotoxic T Lymphocytes", "d": [], "t": []}, {"i": "NCIT:C128892", "l": "Type-1 Polarized Dendritic Cell-induced Antigen-specific Autologous Cytotoxic T Lymphocytes", "d": ["A preparation of autologous cytotoxic T-lymphocytes (CTL), specifically reactive to melanoma-associated antigen 3 (MAGE-3), MAGE-4, survivin, human epidermal growth factor receptor 2 (HER2; ERBB2) and cyclooxygenase-2 (COX-2), with potential immunomodulating activity. Peripheral blood mononuclear cells (PBMCs) are collected from the patient. Subsequently, autologous dendritic cells (DCs) are separated, treated with a certain combination of cytokines to produce polarized type-1 DCs (DC1), and then are loaded with MAGE-3/MAGE-4/survivin/HER2/COX-2 CTL epitope peptides. In turn, autologous CTLs are collected, exposed ex vivo to the antigen-loaded DC1s and subsequently expanded in vitro. Upon re-infusion of the DC1-induced MAGE-3/MAGE-4/survivin/HER2/COX-2-specific autologous CTLs, the CTLs target and lyse tumor cells expressing the tumor-associated antigens (TAAs). Exposure to DC1s generates more potent CTLs and thus induces a more potent CTL response against TAA-expressing tumor cells. The targeted TAAs play key roles in cellular proliferation and are overexpressed by a variety of cancer cell types."], "t": []}], "preferred_name": "Type-1 Polarized Dendritic Cell-induced Antigen-specific Autologous Cytotoxic T Lymphocytes", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5983482", "l": "Persicabtagene Lemgedleucel", "d": [], "t": []}, {"i": "NCIT:C211697", "l": "Persicabtagene Lemgedleucel", "d": [], "t": []}], "preferred_name": "Persicabtagene Lemgedleucel", "taxa": []}
{"type": "biolink:Cell", "ic": 81.34422831136257, "identifiers": [{"i": "UMLS:C5419877", "l": "Anti-CD7 CAR-T", "d": [], "t": []}, {"i": "NCIT:C172817", "l": "Anti-CD7 CAR T-cells", "d": ["A preparation of T-lymphocytes that have been genetically engineered to express a chimeric antigen receptor (CAR) directed against the tumor-associated antigen (TAA) CD7, with potential immunostimulating and antineoplastic activities. Upon administration, the anti-CD7 CAR T-cells specifically recognize and bind to CD7-expressing tumor cells, resulting in specific T-cell-mediated tumor cell lysis. CD7 is a transmembrane glycoprotein expressed by T-cells and natural killer (NK) cells and their precursors. It is expressed in the majority of lymphoblastic T-cell leukemias and lymphomas and in a subset of peripheral T-cell lymphomas."], "t": []}, {"i": "NCIT:C201177", "l": "Anti-CD7 CAR T Cells Preparation", "d": ["Any preparation of chimeric antigen receptor (CAR) expressing T-lymphocytes that targets the tumor-associated antigen (TAA) CD7."], "t": []}], "preferred_name": "Anti-CD7 CAR-T", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C4725853", "l": "AMG-119", "d": [], "t": []}, {"i": "NCIT:C150586", "l": "Autologous Anti-DLL3 CAR T-Cells AMG 119", "d": ["A preparation of autologous T-lymphocytes that are genetically engineered to express a chimeric antigen receptor (CAR) that targets the tumor-associated antigen (TAA) delta-like ligand 3 (DLL3), with potential immunomodulatory and antineoplastic activities. Upon administration of the autologous anti-DLL3 CAR T-cells AMG 119, the T-cells target, bind to and induce selective cytotoxicity in tumor cells expressing DLL3. DLL3, an inhibitory Notch ligand, is expressed on the surface of some cancer cell types but is minimally expressed in normal tissues."], "t": []}], "preferred_name": "AMG-119", "taxa": []}
{"type": "biolink:Cell", "ic": 88.20185721311867, "identifiers": [{"i": "CL:0000373", "l": "histoblast", "d": ["A progenitor cell found in the larval epidermis of insects and that gives rise to the adult abdominal epidermis."], "t": []}], "preferred_name": "histoblast", "taxa": []}
{"type": "biolink:Cell", "ic": 92.76600187037766, "identifiers": [{"i": "UMLS:C1514031", "l": "Neoplastic Multinucleated Stromal Cell", "d": [], "t": []}, {"i": "NCIT:C37124", "l": "Neoplastic Multinucleated Stromal Cell", "d": [], "t": []}], "preferred_name": "Neoplastic Multinucleated Stromal Cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0225468", "l": "Structure of posterior cells of ethmoid sinus", "d": [], "t": []}, {"i": "SNOMEDCT:5890002", "l": "", "d": [], "t": []}], "preferred_name": "Structure of posterior cells of ethmoid sinus", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5856620", "l": "Cell of Origin", "d": [], "t": []}, {"i": "NCIT:C201094", "l": "Cell of Origin", "d": ["The normal cell in which mutation leads to the initiation of a neoplastic process."], "t": []}], "preferred_name": "Cell of Origin", "taxa": []}
{"type": "biolink:Cell", "ic": 72.9312568671559, "identifiers": [{"i": "CL:0002254", "l": "epithelial cell of small intestine", "d": ["An epithelial cell of the lining of the small intestine."], "t": []}, {"i": "UMLS:C2325931", "l": "Epithelial cell of small intestine", "d": [], "t": []}], "preferred_name": "epithelial cell of small intestine", "taxa": []}
{"type": "biolink:Cell", "ic": 86.30756602822301, "identifiers": [{"i": "UMLS:C1514051", "l": "Neoplastic Non-Cutaneous Basaloid Cell", "d": [], "t": []}, {"i": "NCIT:C36782", "l": "Neoplastic Non-Cutaneous Basaloid Cell", "d": [], "t": []}], "preferred_name": "Neoplastic Non-Cutaneous Basaloid Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 40.925146550414475, "identifiers": [{"i": "UMLS:C1512100", "l": "Dysplastic Epithelial Cell", "d": [], "t": []}, {"i": "NCIT:C36807", "l": "Dysplastic Epithelial Cell", "d": [], "t": []}], "preferred_name": "Dysplastic Epithelial Cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0682520", "l": "canine cell line", "d": [], "t": []}], "preferred_name": "canine cell line", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0000590", "l": "small luteal cell", "d": ["A progesterone secreting cell in the corpus luteum that develops from theca cells."], "t": []}], "preferred_name": "small luteal cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4033107", "l": "superior cervical ganglion CGRP neuron", "d": ["A sympathetic neuron that has the soma located in the superior cervical ganglion and expresses the marker calcitonin gene-related peptide (CGRP)."], "t": []}], "preferred_name": "superior cervical ganglion CGRP neuron", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0945928", "l": "CD38+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:116827004", "l": "", "d": [], "t": []}], "preferred_name": "CD38+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5216262", "l": "Malignant cells|NCnc|Pt|Periton fld", "d": [], "t": []}], "preferred_name": "Malignant cells|NCnc|Pt|Periton fld", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0007018", "l": "epidermal ciliary cell", "d": ["Ciliated cell of the embryonic epidermis and functions in embryonic movements."], "t": []}], "preferred_name": "epidermal ciliary cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1440416", "l": "Cells.t(9;11)(p22;q23)(MLLT3,MLL)", "d": [], "t": []}], "preferred_name": "Cells.t(9;11)(p22;q23)(MLLT3,MLL)", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1267811", "l": "Lymphocyte positive for CD1A antigen", "d": [], "t": []}, {"i": "SNOMEDCT:117514000", "l": "", "d": [], "t": []}], "preferred_name": "Lymphocyte positive for CD1A antigen", "taxa": []}
{"type": "biolink:Cell", "ic": 58.94846981566153, "identifiers": [{"i": "CL:0000764", "l": "erythroid lineage cell", "d": ["A immature or mature cell in the lineage leading to and including erythrocytes."], "t": []}], "preferred_name": "erythroid lineage cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1518847", "l": "Pagetoid Cell", "d": [], "t": []}, {"i": "NCIT:C36871", "l": "Pagetoid Cell", "d": [], "t": []}], "preferred_name": "Pagetoid Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C3896612", "l": "Tumor Antigen-reactive CD28+/CCR7+/CD27+/CD45RA- Cytotoxic T-lymphocyte", "d": [], "t": []}, {"i": "NCIT:C118848", "l": "Tumor Antigen-reactive CD28+/CCR7+/CD27+/CD45RA- Cytotoxic T-lymphocyte", "d": ["A subset of rapidly expanding, tumor antigen-reactive central memory cytotoxic T-lymphocytes (CTLs) with a broad expression profile for markers of immune function (MIF), and a particular phenotype of CD28+/CCR7+/CD27+/CD45RA-. These CTLs are formed in vivo following administration of AGS-003 (an autologous, CD40L and tumor antigen RNA-transfected dendritic cell (DC) immunotherapeutic agent), secrete multiple cytokines, including interferon-gamma (IFN-g), tumor necrosis factor-alpha (TNF-a), and interleukin-2 (IL-2), and cause cell lysis. These antigen-reactive, CD28+/CCR7+/CD27+/CD45RA- CTLs, and the phenotype changes in the patient's peripheral blood CTL pool, can be used as a marker to evaluate a patient's immune response against the administered immunotherapeutic agent AGS-003."], "t": []}], "preferred_name": "Tumor Antigen-reactive CD28+/CCR7+/CD27+/CD45RA- Cytotoxic T-lymphocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "CL:4030068", "l": "L6 intratelencephalic projecting Car3 glutamatergic neuron", "d": ["A transcriptomically distinct intratelencepalic-projecting glutamatergic neuron that expresses Car3 with a soma found in L6."], "t": []}], "preferred_name": "L6 intratelencephalic projecting Car3 glutamatergic neuron", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5216300", "l": "Nucleated cells|NCnc|Pt|Dial fld", "d": [], "t": []}], "preferred_name": "Nucleated cells|NCnc|Pt|Dial fld", "taxa": []}
{"type": "biolink:Cell", "ic": 92.76600187037766, "identifiers": [{"i": "CL:0003005", "l": "G4 retinal ganglion cell", "d": ["A mono-stratified retinal ganglion cell that has a small dendritic field and dense dendritic arbor."], "t": []}], "preferred_name": "G4 retinal ganglion cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1514965", "l": "Mouse Stem Cell", "d": [], "t": []}, {"i": "NCIT:C22563", "l": "Mouse Stem Cell", "d": [], "t": []}], "preferred_name": "Mouse Stem Cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5163437", "l": "Eosinophils | Body fluid | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Eosinophils | Body fluid | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C2327682", "l": "Chandelier cell of cerebral cortex", "d": [], "t": []}], "preferred_name": "Chandelier cell of cerebral cortex", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0020200", "l": "Hybrid Cells", "d": [], "t": []}, {"i": "MESH:D006822", "l": "Hybrid Cells", "d": [], "t": []}], "preferred_name": "Hybrid Cells", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C2326168", "l": "Oligodendroblast", "d": [], "t": []}], "preferred_name": "Oligodendroblast", "taxa": []}
{"type": "biolink:Cell", "ic": 77.60424150429895, "identifiers": [{"i": "UMLS:C4317010", "l": "Reactive Lymphocyte", "d": [], "t": []}, {"i": "NCIT:C12847", "l": "Reactive Lymphocyte", "d": ["A type of white blood cell that enlarges in response to antigenic stimulation."], "t": []}], "preferred_name": "Reactive Lymphocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5552872", "l": "Autologous NKG2D CAR T Cells KD-025", "d": [], "t": []}, {"i": "NCIT:C179622", "l": "Autologous NKG2D CAR T Cells KD-025", "d": ["A preparation of autologous T-lymphocytes that have been genetically modified to express a chimeric antigen receptor (CAR) encoding human natural-killer group 2, member D receptor protein (NKG2D or KLRK1) coupled to the co-immunostimulatory signaling domain 4-1BB, normally expressed on T-cells, and linked to the intracellular CD3 zeta domain (CD3z), which is needed for TCR signaling, with potential immunostimulating and antineoplastic activities. Upon infusion back into the patient, autologous NKG2D CAR T cells KD-025 specifically recognize and bind to tumor cells expressing NKG2D ligands (NKG2DLs), resulting in cytokine secretion and lysis of NKG2D ligand-expressing tumor cells. NKG2DLs, such as MICA, MICB, and members of the UL16-binding proteins (ULBP)/retinoic acid early transcript 1 (RAET1) family, are overexpressed on a variety of cancer cell types, but are not expressed on most normal, healthy cells."], "t": []}], "preferred_name": "Autologous NKG2D CAR T Cells KD-025", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C3826391", "l": "Erythrocyte disorders", "d": [], "t": []}], "preferred_name": "Erythrocyte disorders", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1515626", "l": "gp100-Reactive Autologous Peripheral Blood Lymphocyte", "d": [], "t": []}, {"i": "NCIT:C38124", "l": "gp100-Reactive Autologous Peripheral Blood Lymphocyte", "d": ["Human peripheral blood lymphocytes (PBL) isolated from a patient, exposed to the tumor-associated antigen gp100 in vitro, and then transferred back to the same patient to target tumor sites expressing gp100. gp100 human antigen is a wild-type self-antigen expressed by melanocytes, pigmented retinal cells and most melanomas. (NCI04)"], "t": []}], "preferred_name": "gp100-Reactive Autologous Peripheral Blood Lymphocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 88.20185721311867, "identifiers": [{"i": "CL:0011006", "l": "Lugaro cell", "d": ["A cerebellar interneuron characterized by a spindle-shaped or triangular soma, parasagittally oriented and located at the border between the granular layer and the Purkinje cell layer. The Lugaro cell extends dendrites predominantly in the parasagittal plane, forming synaptic interactions with basket, stellate, and Golgi cells. Its axonal projections extend upward into the molecular layer, where they form a parasagittal plexus and emit long transverse collaterals that run parallel to the long axis of the cerebellar folia. The Lugaro cell is capable of co-releasing GABA and glycine, as evidenced by the expression of glutamate decarboxylase (GAD65/67) and the glycine transporter GlyT2."], "t": []}], "preferred_name": "Lugaro cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5970204", "l": "Stem cells, apheresis", "d": [], "t": []}, {"i": "SNOMEDCT:1351653002", "l": "", "d": [], "t": []}], "preferred_name": "Stem cells, apheresis", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5964754", "l": "KSQ 004", "d": [], "t": []}], "preferred_name": "KSQ 004", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5157671", "l": "CD8+CD57+ cells | Blood | Cell markers", "d": [], "t": []}], "preferred_name": "CD8+CD57+ cells | Blood | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C4763574", "l": "CD45RA-depleted Donor T-lymphocytes", "d": [], "t": []}, {"i": "NCIT:C157369", "l": "CD45RA-depleted Donor T-lymphocytes", "d": ["A preparation of donor lymphocytes that have been depleted of CD45RA-positive cells, that can potentially be used for immune reconstitution purposes. CD45RA depletion results in a cellular product that contains a high amount of memory T-cells (Tm). Upon infusion of the allogeneic CD45RA-depleted T-lymphocytes after a hematopoietic cell transplantation (HCT), these cells provide Tm recovery and are able to prevent viral infections. The depletion of the CD45RA-positive cells reduces the risk of graft-versus-host disease (GvHD) upon infusion. CD45RA is expressed on naive T-cells, whereas Tm cells are CD45RA-negative. Naive T-cells have the potential to induce GvHD."], "t": []}], "preferred_name": "CD45RA-depleted Donor T-lymphocytes", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5187200", "l": "RBC^Fetus", "d": [], "t": []}], "preferred_name": "RBC^Fetus", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0333852", "l": "Türk cell", "d": [], "t": []}, {"i": "SNOMEDCT:4205002", "l": "", "d": [], "t": []}], "preferred_name": "Türk cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5170947", "l": "Leukocytes | XXX | Cell markers", "d": [], "t": []}], "preferred_name": "Leukocytes | XXX | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5163435", "l": "Eosinophils | Blood | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Eosinophils | Blood | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1507176", "l": "CD4+CD95+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:1373114003", "l": "", "d": [], "t": []}], "preferred_name": "CD4+CD95+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0002594", "l": "smooth muscle cell of the umbilical artery", "d": ["A smooth muscle cell of the umbilical artery."], "t": []}], "preferred_name": "smooth muscle cell of the umbilical artery", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5168981", "l": "Immature lymphocytes | Blood | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Immature lymphocytes | Blood | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4079021", "l": "sacral dorsal root ganglion endothelin-1 neuron", "d": ["A sensory neuron whose soma is located in the sacral dorsal root ganglion and that expresses endothelin-1 (EDN1). In rat DRG, EDN1 immunoreactivity has been detected in a subset of neuron somata (Giaid et al. 1989, PMID:2678100). Endothelin-1 acts as an endogenous pain mediator, sensitizing nociceptors through activation of ETA and ETB receptors, and these neurons are implicated in vascular pain signalling. EDN1-expressing DRG neurons have been characterized in rat; their prevalence and properties in human DRG remain to be systematically determined, as EDN1 is not yet represented in human DRG single-cell transcriptomic datasets."], "t": []}], "preferred_name": "sacral dorsal root ganglion endothelin-1 neuron", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1709541", "l": "Piloid Astrocyte", "d": [], "t": []}, {"i": "NCIT:C45857", "l": "Piloid Astrocyte", "d": [], "t": []}], "preferred_name": "Piloid Astrocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0002568", "l": "mesenchymal stem cell of Wharton's jelly", "d": ["A mesenchymal stem cell that is part of Wharton's jelly."], "t": []}], "preferred_name": "mesenchymal stem cell of Wharton's jelly", "taxa": []}
{"type": "biolink:Cell", "ic": 83.63771255585968, "identifiers": [{"i": "UMLS:C1709170", "l": "Neoplastic Elongated Mononuclear Stromal Cell", "d": [], "t": []}, {"i": "NCIT:C49054", "l": "Neoplastic Elongated Mononuclear Stromal Cell", "d": [], "t": []}], "preferred_name": "Neoplastic Elongated Mononuclear Stromal Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 90.871710685482, "identifiers": [{"i": "CL:0002669", "l": "type III spiral ligament fibrocyte", "d": ["A spiral ligament fibrocyte that is located in the deepest part of the inferior spiral ligament, directly lining the bony otic capsule. Distinguished from ion-transporting Type I and II fibrocytes, it utilises actin-myosin stress fibres and anchoring interactions to regulate basilar membrane tension. It has an elongated morphology, is most numerous in the basal, high-frequency cochlea, and expresses contractile and cytoskeletal proteins in mice, including α‑smooth muscle actin, non‑muscle myosin II, caldesmon, and the water channel Aquaporin‑1(Mahendrasingam et al., 2011; Kelly et al., 2012)."], "t": []}], "preferred_name": "type III spiral ligament fibrocyte", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0312739", "l": "Granular null cell", "d": [], "t": []}, {"i": "SNOMEDCT:67124000", "l": "", "d": [], "t": []}], "preferred_name": "Granular null cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4023159", "l": "double bouquet cell", "d": ["An interneuron that has double bouquet morphology."], "t": []}, {"i": "UMLS:C2323958", "l": "Double bouquet cell of cerebral cortex", "d": [], "t": []}], "preferred_name": "double bouquet cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0009063", "l": "enteroendocrine cell of anorectum", "d": ["An enteroendocrine cell that is located in the anorectum."], "t": []}], "preferred_name": "enteroendocrine cell of anorectum", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5985051", "l": "Original Human Cell Specimen", "d": [], "t": []}, {"i": "NCIT:C213641", "l": "Original Human Cell Specimen", "d": ["A biospecimen comprised of cells that were isolated directly from a human subject, which may be subsequently cultured and subdivided."], "t": []}], "preferred_name": "Original Human Cell Specimen", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4518167", "l": "Population of all band basophils in portion of fluid", "d": [], "t": []}, {"i": "SNOMEDCT:725232005", "l": "", "d": [], "t": []}], "preferred_name": "Population of all band basophils in portion of fluid", "taxa": []}
{"type": "biolink:Cell", "ic": 73.26332733876373, "identifiers": [{"i": "CL:0008009", "l": "transversely striated visceral muscle cell", "d": ["A visceral muscle that is transversely striated.  Examples include the visceral muscle cells of arthropods."], "t": []}], "preferred_name": "transversely striated visceral muscle cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4307115", "l": "ABC NN_1 Cubn arachnoid barrier cell (Mmus)", "d": ["A arachnoid barrier cell of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Prg4 (Mmus), Cubn (Mmus). It is distinguished from other ABC NN cells by expression of Cubn. These cells are located in the brain . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5295 ABC NN_1."], "t": []}], "preferred_name": "ABC NN_1 Cubn arachnoid barrier cell (Mmus)", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4033175", "l": "dorsal root ganglion BRN3A neuron", "d": ["A sensory neuron that has the soma located in the dorsal root ganglion and expresses the pan-sensory transcription factor POU domain, class 4, transcription factor 1 (BRN3A/POU4F1). In humans, BRN3A is expressed by approximately 98% of DRG neurons and serves as a broad marker for the sensory neuron population."], "t": []}], "preferred_name": "dorsal root ganglion BRN3A neuron", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5157504", "l": "CD36 blasts | Blood | Cell markers", "d": [], "t": []}], "preferred_name": "CD36 blasts | Blood | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": 90.871710685482, "identifiers": [{"i": "CL:0008035", "l": "microcirculation associated smooth muscle cell", "d": ["Any vascular associated smooth muscle cell that is part of some microcirculatory vessel."], "t": []}], "preferred_name": "microcirculation associated smooth muscle cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1513032", "l": "Mature Thymocyte", "d": [], "t": []}, {"i": "NCIT:C33062", "l": "Mature Thymocyte", "d": ["A cell derived in the thymus from a T cell progenitor and then differentiates into a T-Lymphocyte."], "t": []}], "preferred_name": "Mature Thymocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4033053", "l": "small bistratified retinal ganglion cell", "d": ["A bistratfied retinal ganglion cell with a small dendritic field that has dendrites in the ON and OFF sublamina of the retinal inner plexiform layer and carries blue-ON/yellow-OFF signals. This cell receives bipolar and amacrine input to both the OFF and ON dendritic tree."], "t": []}], "preferred_name": "small bistratified retinal ganglion cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5706677", "l": "Posoleucel", "d": [], "t": []}], "preferred_name": "Posoleucel", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4050542", "l": "technetium Tc-99m red blood cells", "d": [], "t": []}, {"i": "SNOMEDCT:89818005", "l": "", "d": [], "t": []}], "preferred_name": "technetium Tc-99m red blood cells", "taxa": []}
{"type": "biolink:Cell", "ic": 40.92263890118216, "identifiers": [{"i": "CL:0000031", "l": "neuroblast (sensu Vertebrata)", "d": ["A cell that will develop into a neuron often after a migration phase."], "t": []}, {"i": "UMLS:C0814005", "l": "Neuroblast", "d": [], "t": []}, {"i": "NCIT:C12991", "l": "Neuroblast", "d": ["An embryonic nerve cell capable of differentiating into a neuron."], "t": []}], "preferred_name": "neuroblast (sensu Vertebrata)", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1513018", "l": "Neoplastic Mature-Appearing Adipocyte", "d": [], "t": []}, {"i": "NCIT:C36976", "l": "Neoplastic Mature-Appearing Adipocyte", "d": [], "t": []}], "preferred_name": "Neoplastic Mature-Appearing Adipocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0001042", "l": "T-helper 22 cell", "d": ["CD4-positive, alpha-beta T cell that produces IL-22."], "t": []}], "preferred_name": "T-helper 22 cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4030007", "l": "fallopian tube multiciliated epithelial cell", "d": ["A multi-ciliated epithelial cell that is part of the fallopian tube, mainly found on the apex of the mucosal folds. This cell exhibits a columnar shape with an oval nucleus and is characterized by the presence of cilia on its surface. The coordinated beating of these cilia, together with peristaltic contractions, contributes to the self-propulsion of spermatozoa, the transport of ovum during ovulation and the transport of the fertilized ovum to the intramural fallopian tube."], "t": []}], "preferred_name": "fallopian tube multiciliated epithelial cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:1001220", "l": "arcuate vein endothelial cell", "d": ["Any endothelial cell that is part of some kidney arcuate vein."], "t": []}], "preferred_name": "arcuate vein endothelial cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4246478", "l": "Diencephalic neural crest cell", "d": [], "t": []}], "preferred_name": "Diencephalic neural crest cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4033184", "l": "dorsal root ganglion TRPV1 neuron", "d": ["A sensory neuron that has the soma located in the dorsal root ganglion and expresses the marker transient receptor potential cation channel subfamily V member 1 (TRPV1). TRPV1 is the canonical heat and capsaicin nociceptor marker and is present in approximately 54% of TrkA-positive human DRG neurons."], "t": []}], "preferred_name": "dorsal root ganglion TRPV1 neuron", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4033003", "l": "myoepithelial cell of bronchus submucosal gland", "d": ["A(n) myoepithelial cell that is part of a(n) bronchus submucosal gland."], "t": []}], "preferred_name": "myoepithelial cell of bronchus submucosal gland", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5174655", "l": "Neutrophils.vacuolated | Blood | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Neutrophils.vacuolated | Blood | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C4764367", "l": "iPSC-derived Natural Killer Cells FT500", "d": [], "t": []}, {"i": "NCIT:C158438", "l": "iPSC-derived Natural Killer Cells FT500", "d": ["A preparation of off-the-shelf, natural killer (NK) cells derived from a clonal master induced pluripotent stem cell (iPSC) line, with potential antineoplastic and immunostimulatory activities. Upon administration, iPSC-derived natural killer cells FT500 bind to stress-induced ligands on tumor cells, leading to tumor cell lysis and release of tumor neoantigens. Additionally, iPSC-NK cells secrete inflammatory cytokines and chemokines including interferon-gamma (IFN-gamma), tumor necrosis factor-alpha (TNF-alpha), C-C motif chemokines 3, 4, and 22 (CCL3, CCL4, and CCL22), and C-X-C motif chemokine 10 (CXCL10), thereby enhancing T-cell activity and recruitment to the tumor site."], "t": []}], "preferred_name": "iPSC-derived Natural Killer Cells FT500", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:1001592", "l": "gallbladder glandular cell", "d": ["Glandular cell of gallbladder epithelium."], "t": []}], "preferred_name": "gallbladder glandular cell", "taxa": []}
{"type": "biolink:Cell", "ic": 72.615132056446, "identifiers": [{"i": "UMLS:C1881538", "l": "Malignant Basaloid Cell", "d": [], "t": []}, {"i": "NCIT:C62227", "l": "Malignant Basaloid Cell", "d": [], "t": []}], "preferred_name": "Malignant Basaloid Cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5205547", "l": "Gavocabtagene autoleucel", "d": [], "t": []}], "preferred_name": "Gavocabtagene autoleucel", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5854560", "l": "Autologous Engineered TCR-T Cells KSX01", "d": [], "t": []}, {"i": "NCIT:C200551", "l": "Autologous Engineered TCR-T Cells KSX01", "d": ["A preparation of autologous T-lymphocytes genetically modified to express a T-cell receptor (TCR) specific for an as of yet undisclosed tumor-associated antigen (TAA), with potential antineoplastic activity. Peripheral blood mononuclear cells (PBMCs) are isolated from a patient, transduced with a TCR specific for the TAA, and expanded ex-vivo. Upon reintroduction into the patient, the autologous engineered TCR-T cells KSX01 target and bind to tumor cells expressing the TAA, which may induce cell death in and halt the growth of cancer cells expressing the undisclosed TAA."], "t": []}], "preferred_name": "Autologous Engineered TCR-T Cells KSX01", "taxa": []}
{"type": "biolink:Cell", "ic": 73.26332733876373, "identifiers": [{"i": "UMLS:C1512478", "l": "Hodgkin Cell", "d": [], "t": []}, {"i": "NCIT:C37021", "l": "Hodgkin Cell", "d": [], "t": []}], "preferred_name": "Hodgkin Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0000934", "l": "CD4-positive, alpha-beta cytotoxic T cell", "d": ["A CD4-positive, alpha-beta T cell that has cytotoxic function."], "t": []}], "preferred_name": "CD4-positive, alpha-beta cytotoxic T cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1522105", "l": "Mouse Pre-B-Lymphocyte", "d": [], "t": []}, {"i": "NCIT:C22574", "l": "Mouse Pre-B-Lymphocyte", "d": [], "t": []}], "preferred_name": "Mouse Pre-B-Lymphocyte", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C6070887", "l": "Cells.CD33.recipient derived | Blood or Tissue | Cell markers", "d": [], "t": []}], "preferred_name": "Cells.CD33.recipient derived | Blood or Tissue | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5554901", "l": "Autologous Gamma Delta T-cell Receptor-expressing T-cells TEG002", "d": [], "t": []}, {"i": "NCIT:C178253", "l": "Autologous Gamma Delta T-cell Receptor-expressing T-cells TEG002", "d": ["A preparation of autologous T-lymphocytes genetically engineered to express a defined gamma delta T-cell receptor (TCR), with potential immunomodulating and antineoplastic activities. Upon administration of the autologous gamma delta TCR-expressing T-cells TEG002, these cells secrete interferon-gamma (IFN-g) and exert direct killing of tumor cells. In addition, these cells activate the immune system to exert a cytotoxic T-lymphocyte (CTL) response against tumor cells. Gamma delta T-lymphocytes play a key role in the activation of the immune system and do not require major histocompatibility complex (MHC)-mediated antigen presentation to exert their cytotoxic effect."], "t": []}], "preferred_name": "Autologous Gamma Delta T-cell Receptor-expressing T-cells TEG002", "taxa": []}
{"type": "biolink:Cell", "ic": 74.37365206292206, "identifiers": [{"i": "CL:0000387", "l": "hemocyte (sensu Arthropoda)", "d": ["A blood cell of the circulatory system of arthropods."], "t": []}, {"i": "UMLS:C0019000", "l": "Hemocyte (cell)", "d": [], "t": []}, {"i": "MESH:D006434", "l": "Hemocytes", "d": [], "t": []}], "preferred_name": "hemocyte (sensu Arthropoda)", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4307097", "l": "COP NN_1 Cck committed oligodendrocyte precursor (Mmus)", "d": ["A committed oligodendrocyte precursor of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of 9630013A20Rik (Mmus), Bmp4 (Mmus), Cck (Mmus), Ptger1 (Mmus). It is distinguished from other COP NN_1 cells by expression of Bmp4, Cck, Ptger1. These cells are located in the Isocortex, Olfactory areas, brain . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5277 COP NN_1."], "t": []}], "preferred_name": "COP NN_1 Cck committed oligodendrocyte precursor (Mmus)", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1513964", "l": "Neoplastic Fasciculata Cell", "d": [], "t": []}, {"i": "NCIT:C36926", "l": "Neoplastic Fasciculata Cell", "d": [], "t": []}], "preferred_name": "Neoplastic Fasciculata Cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5177454", "l": "Plasma cells | Body fluid | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Plasma cells | Body fluid | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": 52.29445898610551, "identifiers": [{"i": "CL:0000115", "l": "endothelial cell", "d": ["An endothelial cell comprises the outermost layer or lining of anatomical structures and can be squamous or cuboidal. In mammals, endothelial cell has vimentin filaments and is derived from the mesoderm."], "t": []}, {"i": "UMLS:C0225336", "l": "Endothelial Cells", "d": [], "t": []}, {"i": "NCIT:C12865", "l": "Endothelial Cell", "d": ["The main type of cell forming the lining of blood and lymph vessels and the inner layer of the endocardium."], "t": []}, {"i": "MESH:D042783", "l": "Endothelial Cells", "d": [], "t": []}, {"i": "SNOMEDCT:45709008", "l": "", "d": [], "t": []}], "preferred_name": "endothelial cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1440412", "l": "Cells.t(5;12)(q33.1;p13)(PDGFRB,ETV6)", "d": [], "t": []}], "preferred_name": "Cells.t(5;12)(q33.1;p13)(PDGFRB,ETV6)", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5216266", "l": "Mesothelial cells|NCnc|Pt|Synv fld", "d": [], "t": []}], "preferred_name": "Mesothelial cells|NCnc|Pt|Synv fld", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4697029", "l": "Cells.CD3+CD8+CD27-", "d": [], "t": []}], "preferred_name": "Cells.CD3+CD8+CD27-", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5163721", "l": "Erythrocytes | Peritoneal fluid | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Erythrocytes | Peritoneal fluid | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0596568", "l": "fiber cell", "d": [], "t": []}], "preferred_name": "fiber cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4033099", "l": "outer wall Schlemm's canal endothelial cell", "d": ["A Schlemm's canal endothelial cell that lines the outer wall of the Schlemm's canal. This cell displays a smooth and flat morphology (Dautriche et al., 2015) and it is distinguished by the presence of Weibel-Palade bodies, specialized organelles that produce, store, and release P-Selectin (Hamanaka et al., 1992). This endothelial cell also exhibits stellate (star-shaped) actin arrangements distributed throughout much of the cell (Ethier et al., 2004)."], "t": []}], "preferred_name": "outer wall Schlemm's canal endothelial cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C4725078", "l": "Hepatitis B Virus Antigen Peptides/Hepatitis G2 Cell Protein Lysate-activated Dendritic Cells", "d": [], "t": []}, {"i": "NCIT:C148495", "l": "Hepatitis B Virus Antigen Peptides/Hepatitis G2 Cell Protein Lysate-activated Dendritic Cells", "d": ["A cell-based cancer vaccine composed of autologous dendritic cells (DCs) ex vivo activated with the hepatitis B virus (HBV)-specific tumor-associated antigen (TAA) peptides derived from the patient's tumor and cell lysate proteins harvested from the immortalized human liver cancer cell line HepG2, with potential immunostimulatory and antineoplastic activities. Upon administration, the HBV peptides/HepG2 cell protein lysate-activated DCs expose the immune system to the HBV epitopes and an undefined amount of other TAAs from the HepG2 cell lysate, which may result in the induction of a specific anti-tumor cytotoxic T-lymphocyte (CTL)-mediated immune response against tumor cells expressing the HBV/HepG2 TAAs. HBV TAAs are found on HBV-positive cells and on HBV-induced hepatocellular carcinoma (HBV-HCC)."], "t": []}], "preferred_name": "Hepatitis B Virus Antigen Peptides/Hepatitis G2 Cell Protein Lysate-activated Dendritic Cells", "taxa": []}
{"type": "biolink:Cell", "ic": 88.20185721311867, "identifiers": [{"i": "CL:0000042", "l": "neutrophilic myeloblast", "d": ["A myeloblast committed to the neutrophil lineage. This cell type is GATA-1 positive, C/EBPa-positive, AML-1-positive, c-myb-positive and has low expression of PU.1 transcription factor."], "t": []}], "preferred_name": "neutrophilic myeloblast", "taxa": []}
{"type": "biolink:Cell", "ic": 92.76600187037766, "identifiers": [{"i": "UMLS:C1519742", "l": "UCSF ES Cell Line", "d": [], "t": []}, {"i": "NCIT:C20304", "l": "UCSF ES Cell Line", "d": [], "t": []}], "preferred_name": "UCSF ES Cell Line", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C3282340", "l": "Cells, Cultured, Autologous", "d": [], "t": []}], "preferred_name": "Cells, Cultured, Autologous", "taxa": []}
{"type": "biolink:Cell", "ic": 87.18682603146104, "identifiers": [{"i": "UMLS:C1517654", "l": "Karolinska ES Cell Line", "d": [], "t": []}, {"i": "NCIT:C20267", "l": "Karolinska ES Cell Line", "d": [], "t": []}], "preferred_name": "Karolinska ES Cell Line", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0002373", "l": "growth hormone releasing hormone secreting cell", "d": ["A peptide hormone secreting cell that secretes growth hormone releasing hormone."], "t": []}], "preferred_name": "growth hormone releasing hormone secreting cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4307107", "l": "MOL NN_4 Il33 mature myelinating oligodendrocyte (Mmus)", "d": ["A mature myelinating oligodendrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Opalin (Mmus), Grm3 (Mmus), Gm5087 (Mmus). It is distinguished from other MOL NN_4 cells by expression of Il33, Gm5087. These cells are located in the Isocortex, brain . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5287 MOL NN_4."], "t": []}], "preferred_name": "MOL NN_4 Il33 mature myelinating oligodendrocyte (Mmus)", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5419508", "l": "Autologous Anti-PD-1 Antibody-activated Tumor-infiltrating Lymphocytes", "d": [], "t": []}, {"i": "NCIT:C172191", "l": "Autologous Anti-PD-1 Antibody-activated Tumor-infiltrating Lymphocytes", "d": ["A preparation of autologous tumor infiltrating lymphocytes (TILs) activated by an anti-programmed cell death protein 1 (PD1) antibody, with potential immunomodulating activity. The autologous TILs are isolated from an autologous tumor sample and ex-vivo activated in the presence of anti-PD-1 antibody. Upon infusion of the autologous anti-PD1 antibody-activated TILs back into the patient, the cells specifically target and kill the patient's tumor cells."], "t": []}], "preferred_name": "Autologous Anti-PD-1 Antibody-activated Tumor-infiltrating Lymphocytes", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0004238", "l": "asymmetric bistratified amacrine cell", "d": ["A bistratified amacrine cell with a medium dendritic field, a flat and sparse dendritic arbor, and post-synaptic terminals at the intersections of S1 and S2, and S3 and S4."], "t": []}], "preferred_name": "asymmetric bistratified amacrine cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5814339", "l": "Human heterologous liver cells", "d": [], "t": []}], "preferred_name": "Human heterologous liver cells", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1277065", "l": "Entire interstitial cell of Leydig", "d": [], "t": []}, {"i": "SNOMEDCT:367715001", "l": "", "d": [], "t": []}], "preferred_name": "Entire interstitial cell of Leydig", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5908087", "l": "Cemacabtagene Ansegedleucel", "d": [], "t": []}], "preferred_name": "Cemacabtagene Ansegedleucel", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4052020", "l": "lung resident granzyme K-associated CD8 T cell", "d": ["A granzyme K-associated CD8 T cell that resides in the lung, characterized by the expression of granzyme K (GZMK), and tissue residency markers CD103 and CD49a. This cell exhibits cytotoxic potential through its expression of multiple granzymes (GZMA, GZMB, GZMH, GZMM) in addition to GZMK."], "t": []}], "preferred_name": "lung resident granzyme K-associated CD8 T cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5177459", "l": "Plasma cells monotypic population | Blood | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Plasma cells monotypic population | Blood | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C4744691", "l": "Partially HLA-matched AdV/CMV/EBV-specific Allogeneic T-Lymphocytes", "d": [], "t": []}, {"i": "NCIT:C156256", "l": "Partially HLA-matched AdV/CMV/EBV-specific Allogeneic T-Lymphocytes", "d": ["Partially or closely human leukocyte antigen (HLA)-matched allogeneic cytotoxic T-lymphocytes (CTLs), derived from cell lines, specifically reactive to the three human viruses adenovirus (AdV), cytomegalovirus (CMV) and Epstein-Barr virus (EBV), with potential antiviral activity. Upon infusion of the partially HLA-matched AdV/CMV/EBV-specific allogeneic T-lymphocytes in immunocompromised patients or upon allogeneic hematopoietic stem cell transplantation (HSCT) in an immunodeficient recipient, these CTLs may kill AdV, CMV, and/or EBV-infected cells, and may prevent or reduce the severity of viral infections by these pathogens."], "t": []}], "preferred_name": "Partially HLA-matched AdV/CMV/EBV-specific Allogeneic T-Lymphocytes", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5382940", "l": "Interferon-gamma producing HLA-A2 Cytomegalovirus specific CD8 cells | Blood | Cell markers", "d": [], "t": []}], "preferred_name": "Interferon-gamma producing HLA-A2 Cytomegalovirus specific CD8 cells | Blood | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0546507", "l": "P.B. mast cell", "d": [], "t": []}], "preferred_name": "P.B. mast cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4241119", "l": "Mesencephalic neural crest cell", "d": [], "t": []}], "preferred_name": "Mesencephalic neural crest cell", "taxa": []}
{"type": "biolink:Cell", "ic": 90.871710685482, "identifiers": [{"i": "UMLS:C1513980", "l": "Neoplastic Gonadotroph Cell", "d": [], "t": []}, {"i": "NCIT:C36921", "l": "Neoplastic Gonadotroph Cell", "d": [], "t": []}], "preferred_name": "Neoplastic Gonadotroph Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 81.743421370964, "identifiers": [{"i": "CL:4023118", "l": "L5/6 non-Martinotti sst GABAergic interneuron (Mmus)", "d": ["A sst GABAergic interneuron does not have Martinotti morphology with a soma found in L5/6 of the cerebral cortex."], "t": []}], "preferred_name": "L5/6 non-Martinotti sst GABAergic interneuron (Mmus)", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0009019", "l": "nephrogenic zone cell", "d": ["A kidney cortical cell that is part of the nephrogenic zone."], "t": []}], "preferred_name": "nephrogenic zone cell", "taxa": []}
{"type": "biolink:Cell", "ic": 83.11065783093733, "identifiers": [{"i": "CL:0000214", "l": "synovial cell", "d": ["A cell located in the synovial joint."], "t": []}, {"i": "UMLS:C0224522", "l": "Synoviocytes", "d": [], "t": []}, {"i": "NCIT:C13059", "l": "Synovial Cell", "d": ["A fibroblast that lies between the cartilaginous fibers in the synovial membrane of joints."], "t": []}, {"i": "MESH:D000070918", "l": "Synoviocytes", "d": [], "t": []}, {"i": "SNOMEDCT:76323008", "l": "", "d": [], "t": []}], "preferred_name": "synovial cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:1000693", "l": "kidney interstitial fibrocyte", "d": ["A stromal cell that infiltrates and resides in the kidney interstitium following injury, characterized by the co-expression of CD45 with mesenchymal markers including α-SMA, and collagen I in humans (Kim et al., 2023). This cell originates from circulating monocyte-derived fibrocytes. It produces extracellular matrix components, contributing to renal fibrosis by potentially differentiating into myofibroblasts upon infiltration into injured kidneys (Sun et al., 2016). Migration into the kidney is dependent on chemokine receptor signaling, particularly CCR2 in mice (Reich et al., 2013)."], "t": []}], "preferred_name": "kidney interstitial fibrocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0007016", "l": "adaxial cell", "d": ["Muscle precursor cell that is adjacent to the notochord and part of the presomitic mesoderm."], "t": []}], "preferred_name": "adaxial cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5666887", "l": "Autologous HIV Gag-specific CD4+ T-cells AGT103-T", "d": [], "t": []}, {"i": "NCIT:C182458", "l": "Autologous HIV Gag-specific CD4+ T-cells AGT103-T", "d": ["A preparation of autologous, human immunodeficiency virus (HIV) Gag-specific, cluster of differentiation 4 (CD4)-positive T-lymphocytes, with potential antiviral activity. Autologous HIV Gag-specific CD4+ T-cells AGT103-T are prepared via ex vivo stimulation of autologous peripheral blood mononuclear cells (PBMCs) with Gag peptides, and the Gag-specific CD4+ T-cells are transduced with the recombinant lentiviral vector AGT103 encoding inhibitory RNA targeting the HIV coreceptor C-C chemokine receptor type 5 (CCR5) and HIV sequences within the Vif/Tat coding regions. Upon administration, autologous HIV Gag-specific CD4+ T-cells AGT103-T may prevent infection by CCR5- or CXCR4-tropic strains of HIV, reduce the depletion of CD4+ T-cells upon HIV exposure and prevent latently-infected cells from releasing new HIV particles."], "t": []}], "preferred_name": "Autologous HIV Gag-specific CD4+ T-cells AGT103-T", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C2324544", "l": "Type I enteric ganglion neuron", "d": [], "t": []}], "preferred_name": "Type I enteric ganglion neuron", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5970776", "l": "remestemcel-L-rknd", "d": [], "t": []}], "preferred_name": "remestemcel-L-rknd", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5555831", "l": "TBX-4000-treated Hematopoietic Stem Cells TBX-2400", "d": [], "t": []}, {"i": "NCIT:C179636", "l": "TBX-4000-treated Hematopoietic Stem Cells TBX-2400", "d": ["An allogeneic cell preparation in which donor-derived hematopoietic stem cells (HSCs) are treated ex vivo with TBX-4000, a recombinant TAT-MYC fusion protein, with potential immunoreconstitutive activity. Upon administration, the TBX-4000-treated HSCs TBX-2400 may enhance the engraftment of the bone marrow upon allogeneic hematopoietic stem cells transplant (HSCT). The TBX-4000 recombinant fusion protein consists of the N-terminal 9 amino acid segment of the HIV TAT protein transduction domain (PTD) fused to the MYC protein. TBX-4000 TAT-MYC rapidly localizes to the nucleus and transiently provides signals to drive proliferation and survival of the HSCs."], "t": []}], "preferred_name": "TBX-4000-treated Hematopoietic Stem Cells TBX-2400", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5157429", "l": "CD3+CD16+CD56+ cells | Bone marrow | Cell markers", "d": [], "t": []}], "preferred_name": "CD3+CD16+CD56+ cells | Bone marrow | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": 87.18682603146104, "identifiers": [{"i": "CL:0000162", "l": "parietal cell", "d": ["An epithelial cell of the stomach that is part of the fundic gastric gland. This cell is characterized by its pyramidal shape, abundant mitochondria, and a complex network of secretory canaliculi lined with microvilli. It secretes hydrochloric acid into the stomach lumen and produces intrinsic factor, essential for vitamin B12 absorption."], "t": []}, {"i": "UMLS:C0030559", "l": "Parietal Cells, Gastric", "d": [], "t": []}, {"i": "NCIT:C12594", "l": "Parietal Cell", "d": ["A large epithelial cell located in the mucous membrane of the stomach that secretes gastric intrinsic factor and hydrochloric acid."], "t": []}, {"i": "MESH:D010295", "l": "Parietal Cells, Gastric", "d": [], "t": []}, {"i": "SNOMEDCT:57041003", "l": "", "d": [], "t": []}], "preferred_name": "parietal cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C3896611", "l": "ROR1 CAR-specific Autologous T-Lymphocytes", "d": [], "t": []}, {"i": "NCIT:C117237", "l": "ROR1 CAR-specific Autologous T-Lymphocytes", "d": ["A mixture of two T-lymphocyte preparations expressing a chimeric antigen receptor (CAR) consisting of an anti-receptor tyrosine kinase-like orphan receptor 1 (ROR1) single chain variable fragment (scFv) fused to either the co-stimulatory signaling domain cluster of differentiation 28 (CD28), and the zeta chain of the T-cell receptor (TCR)/CD3 complex (CD3-zeta) (ROR1CD28zeta), or the co-stimulatory signaling domain cluster of differentiation 137 (CD137; 4-1BB), and the zeta chain of the T-cell receptor (TCR)/CD3 complex (CD3-zeta) (ROR1CD137zeta), with potential immunomodulating and antineoplastic activities. Upon simultaneous administration of the two T-lymphocyte populations ROR1CD28zeta and ROR1CD137zeta , the ROR1 CAR-specific autologous T-lymphocytes are directed to tumor cells expressing ROR1, which may result in a selective toxicity against, and lysis of ROR1-expressing tumor cells. CD28, a T-cell surface-associated co-stimulatory molecule, is required for full T-cell activation, proliferation, and survival. The 4-1BB co-stimulatory molecule signaling domain enhances activation and signaling after recognition of ROR1. ROR1, also known as neurotrophic tyrosine kinase, receptor-related 1, is expressed during embryogenesis and by certain leukemias."], "t": []}], "preferred_name": "ROR1 CAR-specific Autologous T-Lymphocytes", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5161804", "l": "Cytoplasmic Ig mu cells | Blood | Cell markers", "d": [], "t": []}], "preferred_name": "Cytoplasmic Ig mu cells | Blood | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1254945", "l": "Okt3 Lymphocyte", "d": [], "t": []}], "preferred_name": "Okt3 Lymphocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5420429", "l": "Autologous Anti-GD2-CAR-BBz-iCasp9 Retroviral Vector-transduced T Lymphocytes", "d": [], "t": []}, {"i": "NCIT:C173886", "l": "Autologous Anti-GD2-CAR-BBz-iCasp9 Retroviral Vector-transduced T Lymphocytes", "d": ["A preparation of genetically modified autologous T-lymphocytes transduced with a retroviral vector encoding a chimeric antigen receptor (CAR) consisting of a single chain variable fragment (scFv) derived from the monoclonal antibody 14g2a that is specific for the disialoganglioside GD2 and the co-stimulatory domain 4-1BB (CD137) coupled to the zeta chain of the TCR/CD3 complex (CD3-zeta), and fused with the suicide gene inducible caspase 9 (iCasp9), with potential immunomodulating and antineoplastic activities. Upon intravenous administration of the autologous anti-GD2-CAR-BBz-iCasp9 retroviral vector-transduced T lymphocytes, these cells target the GD2 antigen on tumor cells, thereby providing selective toxicity towards GD2-expressing tumor cells. The tumor-associated antigen (TAA) GD2 is overexpressed on the surface of neuroblastoma cells and by other neuroectoderm-derived neoplasms, while it is minimally expressed on normal cells. iCasp9 consists of a human FK506 drug-binding domain with an F36V mutation (FKBP12-F36V) linked to human caspase 9. If the administered T-cells lead to unacceptable side effects, the chemical homodimerizer AP1903 can be administered; this binds to the drug binding FKBP12-F36V domain and activates caspase 9, which results in the apoptosis of the administered T-cells and enhances safety of this agent."], "t": []}], "preferred_name": "Autologous Anti-GD2-CAR-BBz-iCasp9 Retroviral Vector-transduced T Lymphocytes", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5174627", "l": "Neutrophils | Vitreous fluid | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Neutrophils | Vitreous fluid | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5427579", "l": "Rods.right", "d": [], "t": []}], "preferred_name": "Rods.right", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5706508", "l": "AVR-RD-01", "d": [], "t": []}], "preferred_name": "AVR-RD-01", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4079024", "l": "sacral dorsal root ganglion peripherin neuron", "d": ["A small-diameter sensory neuron whose soma is located in the sacral dorsal root ganglion and that expresses peripherin (encoded by PRPH), a type III intermediate filament protein. This neuron is unmyelinated, conducts action potentials as a C-fiber, and encompasses nociceptive and thermoceptive functional subpopulations. In human DRG, peripherin-immunoreactive neurons are predominantly of small diameter (Chang et al. 2018, PMID:28424991), distinguishing them from large-diameter myelinated A-fiber neurons that instead express neurofilament heavy chain (Haberberger et al. 2019, PMID:31293388). In mice, peripherin similarly marks unmyelinated primary afferent neurons."], "t": []}], "preferred_name": "sacral dorsal root ganglion peripherin neuron", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4310136", "l": "STRv D1 medium spiny neuron (Primate)", "d": ["A nucleus accumbens shell and olfactory tubercle D1 medium spiny neuron of the Primates brain. These cells are located in the striatum . Reference transcriptomic data for this type can be found in the dataset/taxonomy - HMBA Basal Ganglia Consensus Taxonomy in cell set Group:STRv D1 MSN."], "t": []}], "preferred_name": "STRv D1 medium spiny neuron (Primate)", "taxa": []}
{"type": "biolink:Cell", "ic": 88.20185721311867, "identifiers": [{"i": "CL:0002224", "l": "lens epithelial cell", "d": ["A cell of the cuboidal epithelium that covers the lens. The cells of the lens epithelium regulate most of the homeostatic functions of the lens. As ions, nutrients, and liquid enter the lens from the aqueous humor, Na+/K+ ATPase pumps in the lens epithelial cells pump ions out of the lens to maintain appropriate lens osmolarity and volume, with equatorially positioned lens epithelium cells contributing most to this current. The activity of the Na+/K+ ATPases keeps water and current flowing through the lens from the poles and exiting through the equatorial regions. The cells of the lens epithelium also serve as the progenitors for new lens fibers. It constantly lays down fibers in the embryo, fetus, infant, and adult, and continues to lay down fibers for lifelong growth."], "t": []}, {"i": "UMLS:C2325187", "l": "Lens epithelial cell", "d": [], "t": []}], "preferred_name": "lens epithelial cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1510966", "l": "ASC-H", "d": [], "t": []}, {"i": "NCIT:C37255", "l": "Atypical Squamous Cell, cannot exclude a High Grade Lesion", "d": [], "t": []}], "preferred_name": "ASC-H", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C2339863", "l": "Transitional myocyte of atrioventricular node", "d": [], "t": []}], "preferred_name": "Transitional myocyte of atrioventricular node", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5761849", "l": "Zevor-cel", "d": [], "t": []}], "preferred_name": "Zevor-cel", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0020012", "l": "hair follicle isthmus-associated fibroblast", "d": ["A fibroblast that is part of the hair follicle isthmus (mid-hair shaft). In humans, this cell expresses CRABP1/COCH/RSPO4 and tendon-associated genes (MKX, TNMD)."], "t": []}], "preferred_name": "hair follicle isthmus-associated fibroblast", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5157356", "l": "CD19+CD38+ cells | Blood | Cell markers", "d": [], "t": []}], "preferred_name": "CD19+CD38+ cells | Blood | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0020027", "l": "alpha retinal ganglion cell ON-transient (Mmus)", "d": ["An alpha retinal ganglion cell subtype in the mouse retina that responds selectively and transiently to increases in light intensity. It possesses the large soma and expansive dendritic field characteristic of alpha RGCs (Krieger et al., 2017). This cell exhibits a brief, fast-decaying burst of firing at the onset of light increments and contributes to motion detection for luminance increases, forming the ON-branch of the transient magnocellular-like pathway (Krieger et al., 2017; Hahn et al., 2023). Functionally, it corresponds to cluster G19 and aligns transcriptomically with cluster C41 (Krieger et al., 2017; Tran et al., 2019). It is orthologous to the primate ON Parasol RGC (Hahn et al., 2023). Molecularly, it expresses Spp1, Smi32, and Brn3b, but lacks Brn3a, Brn3c, and Calbindin (Krieger et al., 2017)."], "t": []}], "preferred_name": "alpha retinal ganglion cell ON-transient (Mmus)", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4033034", "l": "invaginating midget bipolar cell", "d": ["An ON bipolar cell with a small dendritic tree that forms most of the central (invaginating) elements opposite the synaptic ribbon at the cone triad."], "t": []}], "preferred_name": "invaginating midget bipolar cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4704951", "l": "Multipotent Mesenchymal Stromal Cells", "d": [], "t": []}], "preferred_name": "Multipotent Mesenchymal Stromal Cells", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0034083", "l": "Pulmonary Stretch Receptors", "d": [], "t": []}, {"i": "MESH:D011661", "l": "Pulmonary Stretch Receptors", "d": [], "t": []}], "preferred_name": "Pulmonary Stretch Receptors", "taxa": []}
{"type": "biolink:Cell", "ic": 83.11065783093733, "identifiers": [{"i": "UMLS:C1710606", "l": "Vacuolated Malignant Fibroblast", "d": [], "t": []}, {"i": "NCIT:C49030", "l": "Vacuolated Malignant Fibroblast", "d": [], "t": []}], "preferred_name": "Vacuolated Malignant Fibroblast", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0221284", "l": "Leptocyte", "d": [], "t": []}, {"i": "SNOMEDCT:112660002", "l": "", "d": [], "t": []}, {"i": "SNOMEDCT:259686006", "l": "", "d": [], "t": []}], "preferred_name": "Leptocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4307036", "l": "Astro-NT NN_2 Fam227b astrocyte (Mmus)", "d": ["A astrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Slc7a10 (Mmus), Cyp26b1 (Mmus), Igfbp2 (Mmus), Shroom3 (Mmus). It is distinguished from other Astro-NT NN_2 cells by expression of Fam227b, Shroom3. These cells are located in the Midbrain, Medulla, Pons . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5216 Astro-NT NN_2."], "t": []}], "preferred_name": "Astro-NT NN_2 Fam227b astrocyte (Mmus)", "taxa": []}
{"type": "biolink:Cell", "ic": 59.96565320157528, "identifiers": [{"i": "UMLS:C1518216", "l": "Malignant Neuroendocrine Cell", "d": [], "t": []}, {"i": "NCIT:C36825", "l": "Malignant Neuroendocrine Cell", "d": [], "t": []}], "preferred_name": "Malignant Neuroendocrine Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:1000332", "l": "serous cell of epithelium of terminal bronchiole", "d": ["A serous secreting cell that is part of the epithelium of terminal bronchiole."], "t": []}, {"i": "UMLS:C2333370", "l": "Serous cell of epithelium of terminal bronchiole", "d": [], "t": []}], "preferred_name": "serous cell of epithelium of terminal bronchiole", "taxa": []}
{"type": "biolink:Cell", "ic": 92.76600187037766, "identifiers": [{"i": "UMLS:C1512547", "l": "Hyperchromatic Adipocyte", "d": [], "t": []}, {"i": "NCIT:C36979", "l": "Hyperchromatic Adipocyte", "d": [], "t": []}], "preferred_name": "Hyperchromatic Adipocyte", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1440342", "l": "CD64+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:1372919002", "l": "", "d": [], "t": []}], "preferred_name": "CD64+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0002337", "l": "keratinocyte stem cell", "d": ["A stem cell found in the basal layer of the epidermis, hair follicle, and sebaceous gland, characterised by its quiescent nature, high proliferative potential, and capacity for long-term self-renewal. This cell maintains epidermal homeostasis by producing transit-amplifying cells that differentiate to replenish the stratified squamous epithelium."], "t": []}], "preferred_name": "keratinocyte stem cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1979102", "l": "Blasts.CD123", "d": [], "t": []}], "preferred_name": "Blasts.CD123", "taxa": []}
{"type": "biolink:Cell", "ic": 77.82747199602274, "identifiers": [{"i": "CL:0000119", "l": "cerebellar Golgi cell", "d": ["Large intrinsic neuron located in the granule layer of the cerebellar cortex that extends its dendrites into the molecular layer where they receive contact from parallel fibers. The axon of the Golgi cell ramifies densely in the granule layer and enters into a complex arrangement with mossy fiber terminals and granule cell dendrites to form the cerebellar glomerulus. Llinas, Walton and Lang. In The Synaptic Organization of the Brain. 5th ed. 2004."], "t": []}, {"i": "UMLS:C5197771", "l": "Cerebellar Golgi Cells", "d": [], "t": []}, {"i": "MESH:D000080906", "l": "Cerebellar Golgi Cells", "d": [], "t": []}], "preferred_name": "cerebellar Golgi cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1267896", "l": "Lymphocyte positive for CD24 antigen", "d": [], "t": []}, {"i": "SNOMEDCT:117569002", "l": "", "d": [], "t": []}], "preferred_name": "Lymphocyte positive for CD24 antigen", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4733633", "l": "Autologous CD19-targeted CAR T Cells JWCAR029", "d": [], "t": []}], "preferred_name": "Autologous CD19-targeted CAR T Cells JWCAR029", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C2924222", "l": "Cell negative for CD11c antigen and positive for CD25 antigen", "d": [], "t": []}, {"i": "SNOMEDCT:1373165006", "l": "", "d": [], "t": []}], "preferred_name": "Cell negative for CD11c antigen and positive for CD25 antigen", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0815001", "l": "neuron by chemical response", "d": [], "t": []}], "preferred_name": "neuron by chemical response", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4306426", "l": "pinealocyte (Mmus)", "d": ["A pinealocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Cngb3 (Mmus), Ush2a (Mmus). It is glutamatergic. These cells are located in the brain , in or close to the regions: third ventricle . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:4606 Pineal Crx Glut_1.", "A pinealocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Cngb3 (Mmus), Ush2a (Mmus). It is glutamatergic (inferred from expression of Ddc, Slc17a6, Slc17a7). These cells are located in the brain , in or close to the regions: third ventricle . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:4606 Pineal Crx Glut_1."], "t": []}], "preferred_name": "pinealocyte (Mmus)", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0009009", "l": "paneth cell of colon", "d": ["A paneth cell that is located in the epithelium of the colon."], "t": []}, {"i": "UMLS:C2338897", "l": "Paneth cell of epithelium of large intestine", "d": [], "t": []}], "preferred_name": "paneth cell of colon", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0002135", "l": "nonkeratinized cell of epidermis", "d": ["Epidermal cells that do not contain keratin. Cell type is usually associated with moist epidermal tissues."], "t": []}, {"i": "UMLS:C1179445", "l": "Nonkeratinized cell of epidermis", "d": [], "t": []}], "preferred_name": "nonkeratinized cell of epidermis", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5181478", "l": "Spherocytes | Blood | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Spherocytes | Blood | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5417911", "l": "Autologous Anti-CD19 T-cell Receptor Fusion Construct T-cells TC-110", "d": [], "t": []}, {"i": "NCIT:C172366", "l": "Autologous Anti-CD19 T-cell Receptor Fusion Construct T-cells TC-110", "d": ["A preparation of autologous T-lymphocytes that have been genetically engineered to express a single-domain antibody that recognizes human CD19, fused to the CD3-epsilon T-cell receptor (TCR) subunit which, upon expression is incorporated into the endogenous TCR complex, with potential antineoplastic activity. Upon administration, the autologous anti-CD19 TCR fusion construct (TRuC) T-cells TC-110 specifically target and bind to CD19-expressing tumor cells. This leads to T-cell activation and T-cell mediated lysis of CD19-expressing tumor cells. CD19 antigen is a B-cell specific cell surface antigen overexpressed in B-cell lineage malignancies. Compared to chimeric antigen receptor (CAR) T-cells, TRuCs may be associated with less pro-inflammatory cytokine secretion and fewer adverse effects without compromising therapeutic efficacy."], "t": []}], "preferred_name": "Autologous Anti-CD19 T-cell Receptor Fusion Construct T-cells TC-110", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0001080", "l": "NKp44-negative group 3 innate lymphoid cell, human", "d": ["A group 3 innate lymphoid cell in the human with the phenotype IL-7Ralpha-positive, and NKp44-negative."], "t": []}], "preferred_name": "NKp44-negative group 3 innate lymphoid cell, human", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0009070", "l": "corticomedullary thymic epithelial cell", "d": ["A thymic epithelial cell located at the corticomedullary junction."], "t": []}], "preferred_name": "corticomedullary thymic epithelial cell", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "UMLS:C1516515", "l": "Chromophobe cell", "d": [], "t": []}, {"i": "NCIT:C32313", "l": "Chromophobe Cell", "d": ["A small, faintly staining cell with scanty cytoplasm and rounded or polygonal contours. It is found in clusters in the anterior lobe of the pituitary gland."], "t": []}], "preferred_name": "Chromophobe cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4733688", "l": "autologous tri-functional anti-CD19 CAR T cells", "d": [], "t": []}], "preferred_name": "autologous tri-functional anti-CD19 CAR T cells", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1440230", "l": "Cells.aneuploid.population 2", "d": [], "t": []}], "preferred_name": "Cells.aneuploid.population 2", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0020036", "l": "oRGC1", "d": ["A conserved retinal ganglion cell orthotype whose transcriptomic profile groups together OFF midget RGCs from primate foveal and peripheral retina with their molecularly homologous mouse alpha RGC subtype (OFF-sustained alpha-RGC, C42) (Hahn et al., 2023; Tran et al., 2019). Reference to the transcriptomic evidence is found at: GSE237215."], "t": []}], "preferred_name": "oRGC1", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4307035", "l": "Astro-NT NN_2 Sez6l astrocyte (Mmus)", "d": ["A astrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Gja1 (Mmus), A330076C08Rik (Mmus), Otx2 (Mmus), Unc13c (Mmus). It is distinguished from other Astro-NT NN_2 cells by expression of Sez6l, Unc13c. These cells are located in the Thalamus , in or close to the regions: Posterior complex of the thalamus, Ventral posteromedial nucleus of the thalamus . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5215 Astro-NT NN_2."], "t": []}], "preferred_name": "Astro-NT NN_2 Sez6l astrocyte (Mmus)", "taxa": []}
{"type": "biolink:Cell", "ic": 90.871710685482, "identifiers": [{"i": "CL:0000778", "l": "mononuclear osteoclast", "d": ["A specialized mononuclear osteoclast associated with the absorption and removal of bone, precursor of multinuclear osteoclasts."], "t": []}], "preferred_name": "mononuclear osteoclast", "taxa": []}
{"type": "biolink:Cell", "ic": 52.8840847689946, "identifiers": [{"i": "CL:0002139", "l": "endothelial cell of vascular tree", "d": ["An endothelial cell of the vascular tree, which includes blood vessels and lymphatic vessels."], "t": []}, {"i": "UMLS:C1180237", "l": "Cuboidal endothelial cell of vascular tree", "d": [], "t": []}], "preferred_name": "endothelial cell of vascular tree", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5571777", "l": "CD19+CD79b+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:1372986004", "l": "", "d": [], "t": []}], "preferred_name": "CD19+CD79b+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5216321", "l": "Unidentified cells|NCnc|Pt|CSF", "d": [], "t": []}], "preferred_name": "Unidentified cells|NCnc|Pt|CSF", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1267703", "l": "Inner mesothelial cell of arachnoid", "d": [], "t": []}, {"i": "SNOMEDCT:110662000", "l": "", "d": [], "t": []}], "preferred_name": "Inner mesothelial cell of arachnoid", "taxa": []}
{"type": "biolink:Cell", "ic": 84.21065366064373, "identifiers": [{"i": "CL:0000135", "l": "circulating fibrocyte", "d": ["A bone marrow-derived cell that predominantly develops from myeloid lineage-restricted progenitor cells and circulates in peripheral blood, characterized by co-expression of hematopoietic markers CD45 and CD34 along with stromal markers including collagen type I in both humans and mice (Chesney et al., 1997; Blakaj and Bucala, 2012). This spindle-shaped cell exhibits a unique dual identity, functionally bridging immune and stromal compartments with characteristics of both monocytes and fibroblasts. Predominantly arising from circulating monocytes, it migrates to injury sites via chemokine receptors and participates in wound repair through extracellular matrix deposition, cytokine secretion, and antigen presentation via MHC class II. As mesenchymal progenitors, fibrocytes can differentiate into fibroblasts, myofibroblasts, and adipocytes, contributing to both physiological repair and pathological fibrosis (Blakaj and Bucala, 2012)."], "t": []}, {"i": "UMLS:C0225332", "l": "Fibrocyte", "d": [], "t": []}, {"i": "NCIT:C120463", "l": "Fibrocyte", "d": ["A quiescent connective tissue cell with minimal cytoplasm and little to no evidence of protein synthesis. These cells may be able to differentiate into fibroblasts."], "t": []}, {"i": "SNOMEDCT:24735009", "l": "", "d": [], "t": []}], "preferred_name": "circulating fibrocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:1000850", "l": "macula densa epithelial cell", "d": ["An epithelial cell that is part of the macula densa, characterized by a tightly packed arrangement, apically positioned nuclei, and prominent primary cilia, creating a distinctive 'dense spot' appearance under microscopy. It is involved in regulating renal blood flow, glomerular filtration rate, and renin release."], "t": []}], "preferred_name": "macula densa epithelial cell", "taxa": []}
{"type": "biolink:Cell", "ic": 55.55393824135792, "identifiers": [{"i": "CL:4052002", "l": "syncytial cell", "d": ["A multinucleate cell formed by the fusion of multiple uninuclear cells through plasma membrane fusion. This process leads to a single large cell containing multiple nuclei within a shared cytoplasm."], "t": []}], "preferred_name": "syncytial cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5216243", "l": "Lymphocytes.abnormal|NCnc|Pt|Bld", "d": [], "t": []}], "preferred_name": "Lymphocytes.abnormal|NCnc|Pt|Bld", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:1000420", "l": "myoepithelial cell of terminal lactiferous duct", "d": ["A myoepithelial cell that is part of the terminal lactiferous duct."], "t": []}, {"i": "UMLS:C1180273", "l": "Myoepithelial cell of terminal lactiferous duct", "d": [], "t": []}], "preferred_name": "myoepithelial cell of terminal lactiferous duct", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:1000376", "l": "Purkinje myocyte of interventricular septum", "d": ["A Purkinje myocyte that is part of the interventricular septum."], "t": []}, {"i": "UMLS:C2332839", "l": "Purkinje myocyte of interventricular septum", "d": [], "t": []}], "preferred_name": "Purkinje myocyte of interventricular septum", "taxa": []}
{"type": "biolink:Cell", "ic": 81.34422831136257, "identifiers": [{"i": "CL:0002435", "l": "CD69-positive, CD8-positive single-positive thymocyte", "d": ["A CD8-positive, CD4-negative thymocyte that expresses high levels of the alpha-beta T cell receptor and is CD69-positive."], "t": []}], "preferred_name": "CD69-positive, CD8-positive single-positive thymocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0020037", "l": "superficial zone articular chondrocyte", "d": ["An articular chondrocyte located in the most superficial zone of articular cartilage, characterized by flattened morphology and tangential alignment parallel to the joint surface, and residing within a matrix of fine collagen fibrils and relatively low proteoglycan content. In mice and humans, this cell typically expresses lubricin (PRG4) and contributes to lubrication and resistance to shear and tensile forces at the cartilage surface."], "t": []}], "preferred_name": "superficial zone articular chondrocyte", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1440396", "l": "CD79+SmIg- cell", "d": [], "t": []}, {"i": "SNOMEDCT:1376052008", "l": "", "d": [], "t": []}], "preferred_name": "CD79+SmIg- cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5170922", "l": "Leukocytes | Bronchial | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Leukocytes | Bronchial | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0369738", "l": "Neutrophils.band form", "d": [], "t": []}], "preferred_name": "Neutrophils.band form", "taxa": []}
{"type": "biolink:Cell", "ic": 69.41822385916035, "identifiers": [{"i": "UMLS:C1514055", "l": "Neoplastic Osteoblast", "d": [], "t": []}, {"i": "NCIT:C36900", "l": "Neoplastic Osteoblast", "d": [], "t": []}], "preferred_name": "Neoplastic Osteoblast", "taxa": []}
{"type": "biolink:Cell", "ic": 92.76600187037766, "identifiers": [{"i": "CL:0000928", "l": "activated CD4-negative, CD8-negative type I NK T cell", "d": ["A type I NK T cell that has been recently activated, secretes interferon-gamma and interleukin-4, and has phenotype CD4-negative, CD8-negative, CD69-positive, and downregulated NK markers."], "t": []}], "preferred_name": "activated CD4-negative, CD8-negative type I NK T cell", "taxa": []}
{"type": "biolink:Cell", "ic": 86.30756602822301, "identifiers": [{"i": "UMLS:C1515140", "l": "T-Lymphocyte with a Post-Thymic Immunophenotype", "d": [], "t": []}, {"i": "NCIT:C39573", "l": "T-Lymphocyte with a Post-Thymic Immunophenotype", "d": [], "t": []}], "preferred_name": "T-Lymphocyte with a Post-Thymic Immunophenotype", "taxa": []}
{"type": "biolink:Cell", "ic": 31.108822510434678, "identifiers": [{"i": "CL:0000211", "l": "electrically active cell", "d": ["A cell whose function is determined by the generation or the reception of an electric signal."], "t": []}], "preferred_name": "electrically active cell", "taxa": []}
{"type": "biolink:Cell", "ic": 68.58662149843437, "identifiers": [{"i": "CL:0002379", "l": "meningothelial cell", "d": ["A neurecto-epithelial cell found in the arachnoid villi of dura mater. This cell type facilitates flow of cerebrospinal fluid into the blood."], "t": []}, {"i": "UMLS:C1513123", "l": "Meningothelial cell", "d": [], "t": []}, {"i": "NCIT:C33095", "l": "Meningothelial Cell", "d": ["The cellular components of the meninges."], "t": []}], "preferred_name": "meningothelial cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C3274464", "l": "Filgrastim-primed Peripheral Blood Progenitor Cells", "d": [], "t": []}, {"i": "NCIT:C98836", "l": "Filgrastim-primed Peripheral Blood Progenitor Cells", "d": ["Peripheral blood progenitor cells (PBPC) primed with a recombinant form of the human granulocyte colony-stimulating factor (filgrastim). As a hematopoietic growth factor, filgrastim is able to mobilize hematopoietic progenitor cells (HPCs) into the peripheral blood which allows for an increased number of HPCs upon collection by leukapheresis. Administration of filgrastim-primed PBPCs following hematopoietic stem cell transplantation provides increased numbers of progenitor cells which may prevent pancytopenia and relapse."], "t": []}], "preferred_name": "Filgrastim-primed Peripheral Blood Progenitor Cells", "taxa": []}
{"type": "biolink:Cell", "ic": 67.18460065295824, "identifiers": [{"i": "CL:0000237", "l": "keratinizing barrier epithelial cell", "d": [], "t": []}], "preferred_name": "keratinizing barrier epithelial cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4033049", "l": "taste receptor cell of tongue", "d": ["A taste receptor cell that is part of a taste bud of a tongue."], "t": []}], "preferred_name": "taste receptor cell of tongue", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5854649", "l": "Allogeneic Anti-CD7 CAR T Cells 4SCAR7U", "d": [], "t": []}, {"i": "NCIT:C201295", "l": "Allogeneic Anti-CD7 CAR T Cells 4SCAR7U", "d": ["A preparation of allogeneic, off-the-shelf (OTS), universal, gene-edited T-lymphocytes expressing a fourth-generation chimeric antigen receptor (CAR) specific for the tumor-associated antigen (TAA) CD7, with potential immunostimulating and antineoplastic activities. Upon administration, allogeneic anti-CD7 CAR T cells 4SCAR7U specifically target and kill CD7-expressing tumor cells. CD7 is a transmembrane glycoprotein expressed by T-cells and natural killer (NK) cells and their precursors. It is expressed in the majority of lymphoblastic T-cell leukemias and lymphomas and in a subset of peripheral T-cell lymphomas."], "t": []}], "preferred_name": "Allogeneic Anti-CD7 CAR T Cells 4SCAR7U", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5421800", "l": "RAPA-501-Allo", "d": [], "t": []}], "preferred_name": "RAPA-501-Allo", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1440241", "l": "CD11+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:1372822001", "l": "", "d": [], "t": []}], "preferred_name": "CD11+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C0312738", "l": "Pre-B Lymphocytes", "d": [], "t": []}, {"i": "NCIT:C33391", "l": "Pre-B Lymphocyte", "d": [], "t": []}, {"i": "SNOMEDCT:25841003", "l": "", "d": [], "t": []}], "preferred_name": "Pre-B Lymphocytes", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:1000290", "l": "myocyte of middle internodal tract", "d": ["A muscle cell that is part of the middle internodal tract."], "t": []}, {"i": "UMLS:C2333057", "l": "Myocyte of middle internodal tract", "d": [], "t": []}], "preferred_name": "myocyte of middle internodal tract", "taxa": []}
{"type": "biolink:Cell", "ic": 77.82747199602274, "identifiers": [{"i": "CL:4023062", "l": "dentate gyrus neuron", "d": ["A neuron with its soma located in the dentate gyrus of the hippocampus."], "t": []}], "preferred_name": "dentate gyrus neuron", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0003007", "l": "G4-OFF retinal ganglion cell", "d": ["A G4 retinal ganglion cell that has post sympatic terminals in sublaminar layers S2 and S3 and is depolarized by decreased illumination of their receptive field center"], "t": []}], "preferred_name": "G4-OFF retinal ganglion cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0282480", "l": "Muscle Fibers, White", "d": [], "t": []}], "preferred_name": "Muscle Fibers, White", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4307044", "l": "Astro-TE NN_3 Cxcl5 astrocyte (Mmus)", "d": ["A astrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Gja1 (Mmus), Cxcl5 (Mmus), Ddn (Mmus). It is distinguished from other Astro-TE NN_3 cells by expression of Cxcl5, Kif5a. These cells are located in the Hippocampal region, Isocortex, Olfactory areas, brain . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5224 Astro-TE NN_3."], "t": []}], "preferred_name": "Astro-TE NN_3 Cxcl5 astrocyte (Mmus)", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5175158", "l": "Nucleated erythrocytes | Body fluid | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Nucleated erythrocytes | Body fluid | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "CL:2000092", "l": "hair follicular keratinocyte", "d": ["Any keratinocyte that is part of a hair follicle."], "t": []}], "preferred_name": "hair follicular keratinocyte", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4733016", "l": "PP14 derivative-treated HLA-matched donor mononuclear cell-enriched leukocytes", "d": [], "t": []}], "preferred_name": "PP14 derivative-treated HLA-matched donor mononuclear cell-enriched leukocytes", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5669238", "l": "Allogeneic CRISPR-edited Anti-CD19 CAR T Cells PACE CART19", "d": [], "t": []}, {"i": "NCIT:C184372", "l": "Allogeneic CRISPR-edited Anti-CD19 CAR T Cells PACE CART19", "d": ["An off-the-shelf (OTS) preparation of human allogeneic T-lymphocytes transduced with a lentiviral vector encoding a chimeric antigen receptor (CAR) consisting of an anti-CD19 single chain variable fragment (scFv) and the co-stimulatory domain 4-1BB (CD137) coupled to the zeta chain of the T-cell receptor (TCR)/CD3 complex (CD3-zeta), and electroporated with clustered regularly interspaced short palindromic repeats (CRISPR)-Cas9 nuclease complex to eliminate the expression of endogenous TCR, HLA class I and HLA class II molecules, with potential immunostimulating and antineoplastic activities. Upon administration, allogeneic CRISPR-edited anti-CD19 CAR T cells PACE CART19 recognize and bind to CD19-expressing tumor cells. This may result in a specific cytotoxic T-lymphocyte (CTL)-mediated killing of CD19-expressing tumor cells. The removal of endogenous TCR, HLA class I and HLA class II molecules prevents allogeneic immune responses and reduces the risk of graft-versus-host disease (GvHD). The tumor-associated antigen (TAA) CD19 is a B-cell specific cell surface antigen overexpressed in B-cell lineage malignancies."], "t": []}], "preferred_name": "Allogeneic CRISPR-edited Anti-CD19 CAR T Cells PACE CART19", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0007007", "l": "notochordal sheath cell", "d": ["Notochordal cell that is part of the outer epithelium of the notochord and surrounds the vacuolated notochord cells."], "t": []}], "preferred_name": "notochordal sheath cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4300407", "l": "Cells.chromosome 7 monosomy", "d": [], "t": []}], "preferred_name": "Cells.chromosome 7 monosomy", "taxa": []}
{"type": "biolink:Cell", "ic": 75.70995031940328, "identifiers": [{"i": "UMLS:C1512107", "l": "Dysplastic Neutrophil", "d": [], "t": []}, {"i": "NCIT:C37031", "l": "Dysplastic Neutrophil", "d": [], "t": []}], "preferred_name": "Dysplastic Neutrophil", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1265917", "l": "Hand-Schüller-Christian histiocyte", "d": [], "t": []}, {"i": "SNOMEDCT:123635008", "l": "", "d": [], "t": []}], "preferred_name": "Hand-Schüller-Christian histiocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 87.18682603146104, "identifiers": [{"i": "CL:0000829", "l": "basophilic myeloblast", "d": ["A myeloblast committed to the basophil lineage."], "t": []}], "preferred_name": "basophilic myeloblast", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5417817", "l": "iPSC-derived CD16/IL-15RF-expressing Anti-CD19 CAR-NK Cells FT596", "d": [], "t": []}, {"i": "NCIT:C170800", "l": "iPSC-derived CD16/IL-15RF-expressing Anti-CD19 CAR-NK Cells FT596", "d": ["An allogeneic, off-the-shelf, chimeric antigen receptor (CAR)-natural killer (NK) cell product derived from a clonal master induced pluripotent stem cell (iPSC) line, and engineered to express a NK cell-specific anti-CD19 CAR, a high-affinity, non-cleavable CD16 (hnCD16) Fc receptor, and a recombinant fusion of IL-15 and IL-15 receptor alpha (IL-15RF), with potential immunostimulatory and antineoplastic activities. Upon administration, iPSC-derived CD16/IL-15RF-expressing Anti-CD19 CAR-NK Cells FT596 recognize, bind to and induce selective cytotoxicity in CD19-expressing tumor cells. IL-15RF enhances the cytotoxic effect of the NK cells and the activated anti-tumor T-cells. When used in combination with monoclonal antibodies, the hnCD16 Fc receptor of FT596 binds to the Fc portion of tumor cell-bound monoclonal antibodies, leading to NK cell activation, cytokine secretion and enhanced antibody-dependent cellular cytotoxicity (ADCC). CD19 antigen is a B-cell specific cell surface antigen expressed in all B-cell lineage malignancies. CD16, also known as Fc-gamma receptor III, is normally expressed on the surface of NK cells, neutrophils, monocytes and macrophages, and plays a key role in initiating ADCC. It is often downregulated in certain cancers, thereby inhibiting the anti-tumor immune response."], "t": []}], "preferred_name": "iPSC-derived CD16/IL-15RF-expressing Anti-CD19 CAR-NK Cells FT596", "taxa": []}
{"type": "biolink:Cell", "ic": 67.22985628720302, "identifiers": [{"i": "CL:0000598", "l": "pyramidal neuron", "d": ["Pyramidal neurons have a pyramid-shaped soma with a single axon, a large apical dendrite and multiple basal dendrites. The apex and an apical dendrite typically point toward the pial surface and other dendrites and an axon emerging from the base. The axons may have local collaterals but also project outside their region. Pyramidal neurons are found in the cerebral cortex, the hippocampus, and the amygdala."], "t": []}], "preferred_name": "pyramidal neuron", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0333793", "l": "Abnormal hematopoietic cell", "d": [], "t": []}, {"i": "SNOMEDCT:107677004", "l": "", "d": [], "t": []}], "preferred_name": "Abnormal hematopoietic cell", "taxa": []}
{"type": "biolink:Cell", "ic": 88.20185721311867, "identifiers": [{"i": "CL:0002004", "l": "CD34-negative, GlyA-negative proerythroblast", "d": ["A proerythoblast that is CD34-negative and GlyA-negative."], "t": []}], "preferred_name": "CD34-negative, GlyA-negative proerythroblast", "taxa": []}
{"type": "biolink:Cell", "ic": 85.53200374075534, "identifiers": [{"i": "CL:0002316", "l": "supporting cell of vestibular epithelium", "d": ["A supporting cell of the vestibular epithelium."], "t": []}, {"i": "UMLS:C1184798", "l": "Supporting cell of vestibular epithelium", "d": [], "t": []}], "preferred_name": "supporting cell of vestibular epithelium", "taxa": []}
{"type": "biolink:Cell", "ic": 92.76600187037766, "identifiers": [{"i": "CL:1001127", "l": "outer renal medulla vasa recta cell", "d": ["Any vasa recta cell that is part of some outer renal medulla vasa recta."], "t": []}], "preferred_name": "outer renal medulla vasa recta cell", "taxa": []}
{"type": "biolink:Cell", "ic": 79.64650900338474, "identifiers": [{"i": "CL:0000843", "l": "follicular B cell", "d": ["A resting mature B cell that has the phenotype IgM-positive, IgD-positive, CD23-positive and CD21-positive, and found in the B cell follicles of the white pulp of the spleen or the corticol areas of the peripheral lymph nodes. This cell type is also described as being CD19-positive, B220-positive, AA4-negative, CD43-negative, and CD5-negative."], "t": []}], "preferred_name": "follicular B cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1520027", "l": "Preganglionic neuron", "d": [], "t": []}, {"i": "NCIT:C33878", "l": "Visceral Efferent Neuron", "d": ["A cell that conducts a nerve impulse that originated in the central nervous system and proceeds towards one of the interior organs of the one of the three cavities of the body."], "t": []}], "preferred_name": "Preganglionic neuron", "taxa": []}
{"type": "biolink:Cell", "ic": 87.18682603146104, "identifiers": [{"i": "CL:1001607", "l": "articular chondrocyte", "d": ["Chondrocyte forming the hyaline cartilage found in joints."], "t": []}], "preferred_name": "articular chondrocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4052053", "l": "uterine natural killer cell 3, human", "d": ["A uterine natural killer subset found in the endometrial lining during the non-pregnant state (Garcia-Alonso et al., 2021) and in the decidua during pregnancy (Vento-Tormo et al., 2018), becoming the dominant uNK subset late in pregnancy. It expresses the uterine resident marker CD49a and is distinguished from uNK1 and uNK2 by CD160 (Marečková et al., 2024) and CD103 expression, the absence of CD39, and low KIR levels (Whettlock et al., 2022). Resembling intraepithelial ILC1 cells, uNK3 primarily supports uterine immune defense (Huhn et al., 2020) and indirectly influences trophoblast behavior through chemokine secretion, such as CCL5 (Vento-Tormo et al., 2018)."], "t": []}], "preferred_name": "uterine natural killer cell 3, human", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0229658", "l": "Proplasmacyte", "d": [], "t": []}, {"i": "SNOMEDCT:24884008", "l": "", "d": [], "t": []}], "preferred_name": "Proplasmacyte", "taxa": []}
{"type": "biolink:Cell", "ic": 73.49439205968403, "identifiers": [{"i": "UMLS:C1514053", "l": "Neoplastic Oligodendrocyte", "d": [], "t": []}, {"i": "NCIT:C37141", "l": "Neoplastic Oligodendrocyte", "d": [], "t": []}], "preferred_name": "Neoplastic Oligodendrocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 72.11981073685999, "identifiers": [{"i": "CL:0002576", "l": "perineurial cell", "d": ["A glial cell that is part of the perineurium. This cell type has thin long bipolar cytoplasmic processes, pinocytotic vesicles, fragments of external lamina and/or external lamina-like material, attachment plaques, and desmosome-like junctions. Perineurial cells historically have been referred to as fibroblasts because of shape; however, unlike fibroblasts, a perineurial cell: does not have a compact nucleus and large endoplasmic reticulum; does have a double basement membrane opposed to a single basal lamina; is carefully joined to other perineurial cells by tight junctions into a single sheet as opposed to arranged in a large mass; and finally, can surround a small axon bundle at a nerve terminal whereas a fibroblast cannot."], "t": []}], "preferred_name": "perineurial cell", "taxa": []}
{"type": "biolink:Cell", "ic": 69.74265740139907, "identifiers": [{"i": "UMLS:C1708907", "l": "Malignant Small Round Cell", "d": [], "t": []}, {"i": "NCIT:C53487", "l": "Malignant Small Round Cell", "d": [], "t": []}], "preferred_name": "Malignant Small Round Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 59.758011302778854, "identifiers": [{"i": "UMLS:C1513713", "l": "Adenocarcinoma Cell with Intracytoplasmic Mucin", "d": [], "t": []}, {"i": "NCIT:C37117", "l": "Adenocarcinoma Cell with Intracytoplasmic Mucin", "d": [], "t": []}], "preferred_name": "Adenocarcinoma Cell with Intracytoplasmic Mucin", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4322814", "l": "CD45RB+ T lymphocyte", "d": [], "t": []}], "preferred_name": "CD45RB+ T lymphocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 88.20185721311867, "identifiers": [{"i": "UMLS:C1513124", "l": "Meningothelial Cell with Clear Cytoplasm", "d": [], "t": []}, {"i": "NCIT:C37160", "l": "Meningothelial Cell with Clear Cytoplasm", "d": [], "t": []}], "preferred_name": "Meningothelial Cell with Clear Cytoplasm", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:1001608", "l": "foreskin fibroblast", "d": ["Fibroblast from foreskin."], "t": []}], "preferred_name": "foreskin fibroblast", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1441342", "l": "100 leukocytes", "d": [], "t": []}], "preferred_name": "100 leukocytes", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1956386", "l": "Interstitial Dendritic Cells", "d": [], "t": []}], "preferred_name": "Interstitial Dendritic Cells", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0002628", "l": "immature microglial cell", "d": ["An immature microglial cell with a ramified morphology."], "t": []}], "preferred_name": "immature microglial cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0002447", "l": "CD94-negative natural killer cell, mouse", "d": ["A NK1.1-positive T cell that is CD94-negative."], "t": []}], "preferred_name": "CD94-negative natural killer cell, mouse", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C3850145", "l": "Commissural Interneurons", "d": [], "t": []}, {"i": "MESH:D066294", "l": "Commissural Interneurons", "d": [], "t": []}], "preferred_name": "Commissural Interneurons", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4038493", "l": "CD3-CD4- cell", "d": [], "t": []}, {"i": "SNOMEDCT:1373184009", "l": "", "d": [], "t": []}], "preferred_name": "CD3-CD4- cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5707037", "l": "Anti-EGFR/Anti-B7-H3 CAR-T Cells", "d": [], "t": []}, {"i": "NCIT:C187337", "l": "Anti-EGFR/Anti-B7-H3 CAR-T Cells", "d": ["A preparation of T-lymphocytes that have been genetically modified to express a chimeric antigen receptor (CAR) targeting the epidermal growth factor receptor (EGFR) and the immunoregulatory protein B7-homologue 3 (B7-H3, CD276), with potential immunostimulating and antineoplastic activities. Upon administration, the anti-EGFR/anti-B7-H3 CAR-T cells target and bind to EGFR-expressing tumor cells and B7-H3-expressing immune and tumor cells, thereby inducing selective toxicity in these cells. EGFR, overexpressed by a variety of cancer cell types, plays a key role in tumor cell proliferation, tumor angiogenesis and radio- and chemoresistance. B7-H3, a type I transmembrane protein and a member of the B7 co-stimulatory protein superfamily, is overexpressed on certain tumor cell types and on various immune cells. It is a negative regulator of T-cell activation and its overexpression plays a key role in tumor cell invasion and metastasis."], "t": []}], "preferred_name": "Anti-EGFR/Anti-B7-H3 CAR-T Cells", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4759709", "l": "Meiotic cell", "d": [], "t": []}, {"i": "SNOMEDCT:55164002", "l": "", "d": [], "t": []}], "preferred_name": "Meiotic cell", "taxa": []}
{"type": "biolink:Cell", "ic": 87.18682603146104, "identifiers": [{"i": "UMLS:C5856639", "l": "Anti-Claudin18.2 CAR T Cells Preparation", "d": [], "t": []}, {"i": "NCIT:C201172", "l": "Anti-Claudin18.2 CAR T Cells Preparation", "d": ["Any preparation of chimeric antigen receptor (CAR) expressing T-lymphocytes that targets the tumor-associated antigen (TAA) Claudin18.2 (CLDN18.2)."], "t": []}], "preferred_name": "Anti-Claudin18.2 CAR T Cells Preparation", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:1000484", "l": "Purkinje myocyte of atrioventricular bundle", "d": ["A Purkinje myocyte that is part of the atrioventricular bundle."], "t": []}, {"i": "UMLS:C2329800", "l": "Purkinje myocyte of atrioventricular bundle", "d": [], "t": []}], "preferred_name": "Purkinje myocyte of atrioventricular bundle", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C6065175", "l": "Mesenchymal Stem Cell-Derived Exosomes", "d": [], "t": []}], "preferred_name": "Mesenchymal Stem Cell-Derived Exosomes", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0000917", "l": "Tc1 cell", "d": ["A CD8-positive, alpha-beta positive T cell that has the phenotype T-bet-positive, eomesodermin-positive, CXCR3-positive, CCR6-negative, and is capable of producing interferon-gamma."], "t": []}], "preferred_name": "Tc1 cell", "taxa": []}
{"type": "biolink:Cell", "ic": 79.9528279018387, "identifiers": [{"i": "CL:0000449", "l": "brown adipocyte", "d": ["A cell from the thermogenic form of adipose tissue found in many species,  particularly in newborns and hibernating mammals, but also in lesser amounts in adults of other mammals including humans. Brown fat is capable of rapid liberation of energy and seems to be important in the maintenance of body temperature immediately after birth and upon waking from hibernation."], "t": []}, {"i": "UMLS:C1720857", "l": "Adipocytes, Brown", "d": [], "t": []}, {"i": "MESH:D052437", "l": "Adipocytes, Brown", "d": [], "t": []}], "preferred_name": "brown adipocyte", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5157537", "l": "CD4+CD25+ cells | Blood | Cell markers", "d": [], "t": []}], "preferred_name": "CD4+CD25+ cells | Blood | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": 89.40238429118027, "identifiers": [{"i": "CL:0002332", "l": "multiciliated epithelial cell of the bronchus", "d": ["A multi-ciliated epithelial cell located in the bronchus epithelium, characterized by a columnar shape and motile cilia on its apical surface."], "t": []}], "preferred_name": "multiciliated epithelial cell of the bronchus", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0000713", "l": "corona radiata cell", "d": [], "t": []}], "preferred_name": "corona radiata cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C6056316", "l": "PBCAR269A", "d": [], "t": []}], "preferred_name": "PBCAR269A", "taxa": []}
{"type": "biolink:Cell", "ic": 83.11065783093733, "identifiers": [{"i": "CL:4300358", "l": "subcortical astrocyte (Mmus)", "d": ["A transcriptomically defined type of astrocyte located predominantly in the ventral and posterior subcortical areas.   It is distinguished from other cells in the brain by selective expression of Aqp4 (Mmus), Cd38 (Mmus), Agt (Mmus), Itih3 (Mmus). Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Subclass:318 Astro-NT NN."], "t": []}], "preferred_name": "subcortical astrocyte (Mmus)", "taxa": []}
{"type": "biolink:Cell", "ic": 90.871710685482, "identifiers": [{"i": "CL:1000313", "l": "gastric goblet cell", "d": ["A goblet cell that is part of the epithelium of stomach."], "t": []}, {"i": "UMLS:C2331996", "l": "Gastric goblet cell", "d": [], "t": []}], "preferred_name": "gastric goblet cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1267913", "l": "Lymphocyte positive for CD36 antigen", "d": [], "t": []}, {"i": "SNOMEDCT:117582005", "l": "", "d": [], "t": []}], "preferred_name": "Lymphocyte positive for CD36 antigen", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C3827871", "l": "T1E28z CAR-expressing Autologous CD4-positive T Lymphocytes", "d": [], "t": []}, {"i": "NCIT:C106117", "l": "T1E28z CAR-expressing Autologous CD4-positive T Lymphocytes", "d": ["Autologous CD4 positive T-lymphocytes engineered to express the chimeric antigen receptor (CAR) T1E28z containing the ErbB ligand, T1E, fused to the hinge region, transmembrane domain and endodomain of CD28 and the CD3zeta endodomain, with potential immunomodulating and antineoplastic activities. T1E, a chimeric polypeptide containing the N-terminus of human transforming growth factor (TGF)-alpha fused to the C-terminus of epidermal growth factor (EGF), binds to ErbB1 homodimers and heterodimers as well as ErbB2/3 heterodimers, but not to ErbB2 or erbB3 alone. Upon intratumoral administration, the promiscuous ErbB ligand T1E of the T1E28z CAR-expressing autologous CD4-positive T lymphocytes binds to the specific ErbB homo- and heterodimers on tumor cells. This induces selective toxicity in ErbB-expressing tumor cells resulting in tumor cell lysis. ErbB1, ErbB2 and ErbB3, members of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases, are frequently overexpressed in solid tumors and play key roles in tumor cell proliferation and tumor angiogenesis."], "t": []}], "preferred_name": "T1E28z CAR-expressing Autologous CD4-positive T Lymphocytes", "taxa": []}
{"type": "biolink:Cell", "ic": 88.20185721311867, "identifiers": [{"i": "CL:1000326", "l": "ileal goblet cell", "d": ["A goblet cell that is part of the epithelium proper of ileum."], "t": []}, {"i": "UMLS:C2332530", "l": "Goblet cell of epithelium proper of ileum", "d": [], "t": []}], "preferred_name": "ileal goblet cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:2000017", "l": "fibroblast of peridontal ligament", "d": ["Any fibroblast that is part of a periodontal ligament."], "t": []}], "preferred_name": "fibroblast of peridontal ligament", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:1001097", "l": "kidney afferent arteriole smooth muscle cell", "d": ["A smooth muscle cell found in the wall of the afferent arteriole. This cell contracts and relaxes in response to changes in blood pressure, a process known as a myogenic response, to alter artery diameter and regulate blood flow into the glomeruli."], "t": []}], "preferred_name": "kidney afferent arteriole smooth muscle cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4300409", "l": "CD3+CD8+CD45RO+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:1373091009", "l": "", "d": [], "t": []}], "preferred_name": "CD3+CD8+CD45RO+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": 68.10263212560105, "identifiers": [{"i": "UMLS:C1709199", "l": "Neoplastic Skeletal Muscle Cell", "d": [], "t": []}, {"i": "NCIT:C49167", "l": "Neoplastic Skeletal Muscle Cell", "d": ["A neoplastic mesenchymal cell that originates from a skeletal muscle cell."], "t": []}], "preferred_name": "Neoplastic Skeletal Muscle Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 87.18682603146104, "identifiers": [{"i": "UMLS:C0025166", "l": "Megakaryocytes", "d": [], "t": []}, {"i": "NCIT:C12553", "l": "Megakaryocyte", "d": ["Very large bone marrow cells which release mature blood platelets."], "t": []}, {"i": "MESH:D008533", "l": "Megakaryocytes", "d": [], "t": []}, {"i": "SNOMEDCT:23592000", "l": "", "d": [], "t": []}], "preferred_name": "Megakaryocytes", "taxa": []}
{"type": "biolink:Cell", "ic": 87.18682603146104, "identifiers": [{"i": "CL:0000960", "l": "T3 B cell", "d": ["A transitional stage B cell that expresses surface IgM and IgD, and CD62L. This cell type appears to be an anergic B cell that does not proliferate upon BCR signaling, is found in the spleen and lymph nodes, and has the phenotype surface IgM-positive, surface IgD-positive, CD21-positive, CD23-positive, CD62L-positive, and CD93-positive. This cell type has also been described as IgM-low, CD19-positive, B220-positive, AA4-positive, and CD23-positive (i.e. this cell-type is distinguished from T2 cells by surface expression of IgM)."], "t": []}], "preferred_name": "T3 B cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4307096", "l": "COP NN_1 Vwc2 committed oligodendrocyte precursor (Mmus)", "d": ["A committed oligodendrocyte precursor of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of 9630013A20Rik (Mmus), Rab32 (Mmus), Opalin (Mmus). It is distinguished from other COP NN_1 cells by expression of Vwc2, Opalin. These cells are located in the brain . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5276 COP NN_1."], "t": []}], "preferred_name": "COP NN_1 Vwc2 committed oligodendrocyte precursor (Mmus)", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1267965", "l": "Lymphocyte positive for CD71 antigen", "d": [], "t": []}, {"i": "SNOMEDCT:116846003", "l": "", "d": [], "t": []}], "preferred_name": "Lymphocyte positive for CD71 antigen", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0002424", "l": "DN2b thymocyte", "d": ["A DN2 thymocyte that is Kit-low."], "t": []}], "preferred_name": "DN2b thymocyte", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1267866", "l": "Lymphocyte positive for CD11A antigen", "d": [], "t": []}, {"i": "SNOMEDCT:117547009", "l": "", "d": [], "t": []}], "preferred_name": "Lymphocyte positive for CD11A antigen", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5177615", "l": "Platelets | Blood | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Platelets | Blood | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0546495", "l": "P.B. basophilic metamyelocyte", "d": [], "t": []}], "preferred_name": "P.B. basophilic metamyelocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0003042", "l": "M9-OFF retinal ganglion cell", "d": ["An M9 retinal ganglion cell with synaptic terminals in S4 that is depolarized by decreased illumination of their receptive field center"], "t": []}], "preferred_name": "M9-OFF retinal ganglion cell", "taxa": []}
{"type": "biolink:Cell", "ic": 81.743421370964, "identifiers": [{"i": "CL:0000439", "l": "prolactin secreting cell", "d": ["A peptide hormone cell that secretes prolactin."], "t": []}], "preferred_name": "prolactin secreting cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1512446", "l": "High Grade Malignant Transitional Cell", "d": [], "t": []}, {"i": "NCIT:C36838", "l": "High Grade Malignant Transitional Cell", "d": [], "t": []}], "preferred_name": "High Grade Malignant Transitional Cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1440411", "l": "Cells.t(4;11)(q21.3;q23)(AFF1,MLL)", "d": [], "t": []}], "preferred_name": "Cells.t(4;11)(q21.3;q23)(AFF1,MLL)", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4518145", "l": "Population of all spermatozoa with duplicate tail in portion of fluid", "d": [], "t": []}, {"i": "SNOMEDCT:725244008", "l": "", "d": [], "t": []}], "preferred_name": "Population of all spermatozoa with duplicate tail in portion of fluid", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0038027", "l": "Reproduction spores", "d": [], "t": []}, {"i": "MESH:D013170", "l": "Spores", "d": [], "t": []}], "preferred_name": "Reproduction spores", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0010014", "l": "type II pinealocyte", "d": [], "t": []}], "preferred_name": "type II pinealocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 75.876659701315, "identifiers": [{"i": "UMLS:C1711388", "l": "Neoplastic Dendritic Cell", "d": [], "t": []}, {"i": "NCIT:C43271", "l": "Neoplastic Dendritic Cell", "d": [], "t": []}], "preferred_name": "Neoplastic Dendritic Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 84.83823963392128, "identifiers": [{"i": "CL:4023036", "l": "pvalb chandelier GABAergic interneuron", "d": ["A transcriptomically distinct pvalb GABAergic interneuron located in the pallium. It is recognizable by the straight terminal axonal 'cartridges' of vertically oriented strings of synaptic boutons. Chandelier PV cells' boutons target exclusively the axon initial segment (AIS) of pyramidal cells, with a single cell innervating hundreds of pyramidal cells in a clustered manner.  These cells are fast-spiking.", "A transcriptomically distinct pvalb GABAergic cortical interneuron that is recognizable by the straight terminal axonal 'cartridges' of vertically oriented strings of synaptic boutons. Chandelier PV cells' boutons target exclusively the axon initial segment (AIS) of pyramidal cells, with a single cell innervating hundreds of pyramidal cells in a clustered manner. The standard transcriptomic reference data for this cell type can be found on the CellxGene census under the collection: 'Transcriptomic cytoarchitecture reveals principles of human neocortex organization', dataset: 'Supercluster: CGE-derived interneurons', Author Categories: 'CrossArea_subclass', clusters Chandelier."], "t": []}], "preferred_name": "pvalb chandelier GABAergic interneuron", "taxa": []}
{"type": "biolink:Cell", "ic": 92.76600187037766, "identifiers": [{"i": "CL:0000658", "l": "cuticle secreting cell", "d": ["An epithelial cell that secretes cuticle."], "t": []}], "preferred_name": "cuticle secreting cell", "taxa": []}
{"type": "biolink:Cell", "ic": 89.40238429118027, "identifiers": [{"i": "UMLS:C1513930", "l": "Neoplastic B-Prolymphocyte", "d": [], "t": []}, {"i": "NCIT:C37183", "l": "Neoplastic B-Prolymphocyte", "d": [], "t": []}], "preferred_name": "Neoplastic B-Prolymphocyte", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0427568", "l": "Platelet satellite", "d": [], "t": []}], "preferred_name": "Platelet satellite", "taxa": []}
{"type": "biolink:Cell", "ic": 73.37784620547062, "identifiers": [{"i": "CL:0002253", "l": "epithelial cell of large intestine", "d": ["An epithelial cell of the lining of the large intestine."], "t": []}, {"i": "UMLS:C2338315", "l": "Epithelial cell of large intestine", "d": [], "t": []}], "preferred_name": "epithelial cell of large intestine", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0002466", "l": "small intestine serosal dendritic cell", "d": ["A CD11b-positive dendritic cell located in the serosal portion of the small intestine epithelium. This cell type is CD45-positive, MHC-II-positive, CD11c-low, CD103-negative."], "t": []}], "preferred_name": "small intestine serosal dendritic cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C3827113", "l": "Autologous Peripheral Blood Lymphocytes Cotransduced with Retroviral Vectors Encoding Inducible IL-12 and Anti-NY-ESO-1 TCR", "d": [], "t": []}, {"i": "NCIT:C113161", "l": "Autologous Peripheral Blood Lymphocytes Cotransduced with Retroviral Vectors Encoding Inducible IL-12 and Anti-NY-ESO-1 TCR", "d": ["Human autologous peripheral blood lymphocytes (PBLs) transduced with two retroviral vectors, one encoding a T-cell receptor (TCR) specific for the cancer-testis antigen NY-ESO-1 and a second that encodes an inducible single chain form of interleukin-12 (IL-12) driven by a nuclear factor of activated T-cells (NFAT)-responsive promoter, with potential immunomodulating and antineoplastic activities. Following isolation of lymphocytes, retroviral vector transduction, and expansion of the cells ex vivo, the inducible IL-12/anti-NY-ESO-1 TCR-expressing autologous PBLs are re-administered into the patient by intravenous injection. As the transduced PBLs traverse the patient's circulation, they can bind to NY-ESO-1-overexpressing tumor cells. This binding activates the TCR signaling pathway in the transduced PBLs, which promotes NFAT-dependent gene transcription and induces expression of the cotransduced IL-12. IL-12 expression activates the immune system by promoting the secretion of interferon-gamma, activating natural killer cells (NKs), and inducing cytotoxic T-cell responses, which may result in both decreased cell proliferation and increased cell death for the NY-ESO-1-overexpressing tumor cells. NY-ESO-1, a tumor associated antigen (TAA), is found in normal testis and on the surface of various tumor cell types. NFAT, a family of transcription factors involved in immune responses, is activated by calcium signaling, which can occur downstream of TCR activation. Use of a retroviral vector to express an inducible IL-12 may remove the requirement for concomitant administration of interleukin-2 (IL-2) as is the case for conventional cell transfer immunotherapies."], "t": []}], "preferred_name": "Autologous Peripheral Blood Lymphocytes Cotransduced with Retroviral Vectors Encoding Inducible IL-12 and Anti-NY-ESO-1 TCR", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0000105", "l": "pseudounipolar neuron", "d": ["Neuron with two neurites that are fused grossly when they protrude from the soma and bifurcate a short distance from the soma."], "t": []}], "preferred_name": "pseudounipolar neuron", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C0229635", "l": "Metamyelocytes", "d": [], "t": []}, {"i": "NCIT:C13116", "l": "Metamyelocyte", "d": ["A cell derived from a promyelocyte and differentiates into a neutrophil. It is nonproliferative and is usually found in bone marrow. Its nucleus is indented and the chromatin clumped and dense."], "t": []}, {"i": "SNOMEDCT:83321009", "l": "", "d": [], "t": []}], "preferred_name": "Metamyelocytes", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C6050181", "l": "Allogeneic TGFBR2 KO CAR27/IL-15-expressing NK Cells", "d": [], "t": []}, {"i": "NCIT:C215857", "l": "Allogeneic TGFBR2 KO CAR27/IL-15-expressing NK Cells", "d": ["A preparation of allogeneic, umbilical cord blood (CB)-derived natural killer cells (NKs) that have been engineered to express a chimeric antigen receptor (CAR) specific for the tumor-associated antigen (TAA) human cluster of differentiation 70 (CD70) and expressing the cytokine interleukin-15 (IL-15) and in which the gene transforming growth factor-beta receptor II (TGFbRII; TGFBR2) is deleted through clustered regularly interspaced short palindromic repeats (CRISPR)-Cas 9 gene editing, with potential immunostimulating and antineoplastic activities. Upon administration, the allogeneic TGFBR2 KO CAR27/IL-15-expressing NK cells target, bind to and induce selective cytotoxicity in CD70-expressing tumor cells. CD70, the ligand for the costimulatory receptor CD27, is overexpressed on the surfaces of various cancer cell types. IL-15 is a pro-survival cytokine that promotes persistence of multiple lymphocyte lineages and potentiates the immune response against tumor cells. As TGF-beta activation and release leads to NK cell inactivation, deletion of the TGFBR2 gene increases the potency, persistence and efficacy of the NK cells and enhances anti-tumor activity."], "t": []}], "preferred_name": "Allogeneic TGFBR2 KO CAR27/IL-15-expressing NK Cells", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0020042", "l": "oRGC5", "d": ["A conserved retinal ganglion cell orthotype whose transcriptomic profile groups together OFF parasol RGCs from primate foveal and peripheral retina with their molecularly homologous mouse α RGC subtype (OFF-transient α RGC, C45) (Hahn et al., 2023; Tran et al., 2019). Reference to transcriptomic evidence can be found at: GSE237215."], "t": []}], "preferred_name": "oRGC5", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1440375", "l": "CD99+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:1372947003", "l": "", "d": [], "t": []}], "preferred_name": "CD99+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0002388", "l": "multinucleate arthroconidium", "d": ["An arthroconidium that has more than one nucleus."], "t": []}], "preferred_name": "multinucleate arthroconidium", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C4688337", "l": "Autologous Anti-CD19 T-cell Receptor T cells ET190L1", "d": [], "t": []}, {"i": "NCIT:C148030", "l": "Autologous Anti-CD19 T-cell Receptor T cells ET190L1", "d": ["Autologous human peripheral blood T-lymphocytes transduced with a lentivirus encoding a proprietary expression construct composed of a T-cell receptor (TCR)-like human antibody, which is synthesized by a proprietary phage display platform, targeting peptides derived from the tumor-associated antigen (TAA) CD19 that are presented in the context of major histocompatibility complex (MHC) molecules, with potential antineoplastic activity. Following leukapheresis, isolation of lymphocytes, expansion ex vivo, transduction, and re-introduction into the patient, the autologous anti-CD19 TCR T-cells ET190L1 target and bind to tumor cells expressing CD19 peptide/MHC complexes. This results in cytotoxic T-lymphocyte (CTL)-mediated elimination of CD19-positive tumor cells. CD19, cluster of differentiation antigen 19, is a B-cell-specific cell surface antigen overexpressed in B-cell lineage malignancies. ET190L1 is able to match the anticancer activity of chimeric antigen receptor (CAR) T-cells; however, ET190L1 is less likely to stimulate cytokine release syndrome (CRS) and does not cause CAR T-cell-triggered neurotoxicity."], "t": []}], "preferred_name": "Autologous Anti-CD19 T-cell Receptor T cells ET190L1", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C4725101", "l": "Autologous CD20-4SCAR-expressing T-cells 4SCAR20", "d": [], "t": []}, {"i": "NCIT:C148525", "l": "Autologous CD20-4SCAR-expressing T-cells 4SCAR20", "d": ["A preparation of genetically modified autologous T-cells transduced with a replication incompetent, self-inactivating lentiviral vector expressing a  fourth generation chimeric antigen receptor (4SCAR) consisting of an anti-CD20 single chain variable fragment (scFv) that is coupled to the costimulatory signaling domains CD28, CD137, CD27 and the zeta chain of the T-cell receptor (TCR), and is fused with the suicide gene inducible caspase 9 (iCasp9), with potential immunostimulating and antineoplastic activities. Upon intravenous administration, autologous CD20-4SCAR-expressing T-cells 4SCAR20 are directed to and induce selective toxicity in CD20-expressing tumor cells. iCasp9 consists of a human FK506 drug-binding domain with an F36V mutation (FKBP12-F36V) linked to human caspase 9. If the administered T-cells lead to unacceptable side effects, the chemical homodimerizer AP1903 can be administered. AP1903 binds to the drug binding FKBP12-F36V domain and induces activation of caspase 9, which results in the apoptosis of the administered T-cells and enhances safety of this agent. CD20 is a non-glycosylated cell surface phosphoprotein that is exclusively expressed on B-cells during most stages of B-cell development and is often overexpressed in B-cell malignancies. CD28, CD137 and CD27, T-cell surface-associated co-stimulatory molecules, are required for full T-cell activation and enhance both proliferation of T-cells and antitumor activity."], "t": []}], "preferred_name": "Autologous CD20-4SCAR-expressing T-cells 4SCAR20", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C2333855", "l": "Parasympathetic preganglionic neuron", "d": [], "t": []}], "preferred_name": "Parasympathetic preganglionic neuron", "taxa": []}
{"type": "biolink:Cell", "ic": 73.26332733876373, "identifiers": [{"i": "CL:0000622", "l": "acinar cell", "d": ["A secretory cell that is grouped together with other cells of the same type to form grape shaped clusters known as acini (singular acinus)."], "t": []}], "preferred_name": "acinar cell", "taxa": []}
{"type": "biolink:Cell", "ic": 90.871710685482, "identifiers": [{"i": "CL:0000924", "l": "CD4-negative, CD8-negative type I NK T cell", "d": ["A type I NK T cell that has the phenotype CD4-negative and CD8-negative."], "t": []}], "preferred_name": "CD4-negative, CD8-negative type I NK T cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:1001587", "l": "uterine cervix secretory cell", "d": ["Glandular cell of uterine cervix epithelium."], "t": []}], "preferred_name": "uterine cervix secretory cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C3847843", "l": "Basophil positive for CD63 antigen", "d": [], "t": []}, {"i": "SNOMEDCT:724247008", "l": "", "d": [], "t": []}], "preferred_name": "Basophil positive for CD63 antigen", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5170980", "l": "Leukocytes+Platelets | Blood | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Leukocytes+Platelets | Blood | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": 79.64650900338474, "identifiers": [{"i": "CL:0002520", "l": "nephrocyte", "d": ["An insect excretory cell that regulates hemolymph composition by filtration and filtrate endocytosis."], "t": []}, {"i": "UMLS:C2328107", "l": "Nephrocyte", "d": [], "t": []}], "preferred_name": "nephrocyte", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4694618", "l": "Kymriah (Ped ALL)", "d": [], "t": []}], "preferred_name": "Kymriah (Ped ALL)", "taxa": []}
{"type": "biolink:Cell", "ic": 87.18682603146104, "identifiers": [{"i": "CL:0000875", "l": "non-classical monocyte", "d": ["A type of monocyte characterized by low expression of CCR2, low responsiveness to monocyte chemoattractant CCL2/MCP1, low phagocytic activity, and decrease size relative to classical monocytes, but increased co-stimulatory activity. May also play a role in tissue repair."], "t": []}], "preferred_name": "non-classical monocyte", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5401599", "l": "Allogenic Pooled Olfactory Mucosa-derived Mesenchymal Stem Cells", "d": [], "t": []}], "preferred_name": "Allogenic Pooled Olfactory Mucosa-derived Mesenchymal Stem Cells", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5163722", "l": "Erythrocytes | Pleural fluid | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Erythrocytes | Pleural fluid | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0042542", "l": "Vero Cells", "d": [], "t": []}, {"i": "MESH:D014709", "l": "Vero Cells", "d": [], "t": []}], "preferred_name": "Vero Cells", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5827051", "l": "NeuroCell-PD", "d": [], "t": []}], "preferred_name": "NeuroCell-PD", "taxa": []}
{"type": "biolink:Cell", "ic": 83.11065783093733, "identifiers": [{"i": "CL:0002087", "l": "nongranular leukocyte", "d": ["A leukocyte that lacks granules."], "t": []}, {"i": "UMLS:C0023517", "l": "Nongranular leukocyte", "d": [], "t": []}, {"i": "NCIT:C12534", "l": "Non-Granular Leukocyte", "d": ["A white blood cell that lacks cytoplasmic granules with an affinity for specific biological stains; typically, a lymphocyte, monocyte, or plasma cell."], "t": []}, {"i": "MESH:D007963", "l": "Leukocytes, Mononuclear", "d": [], "t": []}], "preferred_name": "nongranular leukocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5666915", "l": "Anti-KLK2 CAR-T Cells JNJ-75229414", "d": [], "t": []}, {"i": "NCIT:C183544", "l": "Anti-KLK2 CAR-T Cells JNJ-75229414", "d": ["A preparation of T-lymphocytes that have been genetically modified to express a chimeric antigen receptor (CAR) targeting human kallikrein-2 (hK2; KLK2) expressed on tumor cells, with potential immunostimulating and antineoplastic activities. Upon administration, anti-KLK2 CAR-T cells JNJ-75229414 target and bind to KLK2-expressing tumor cells, thereby inducing selective toxicity in KLK2-expressing tumor cells. KLK2 is overexpressed in certain tumors, including prostate adenocarcinoma."], "t": []}], "preferred_name": "Anti-KLK2 CAR-T Cells JNJ-75229414", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5165605", "l": "Germ cells.immature | Semen | Fertility testing", "d": [], "t": []}], "preferred_name": "Germ cells.immature | Semen | Fertility testing", "taxa": []}
{"type": "biolink:Cell", "ic": 92.76600187037766, "identifiers": [{"i": "UMLS:C0029431", "l": "Osteoclasts", "d": [], "t": []}, {"i": "NCIT:C12570", "l": "Osteoclast", "d": ["A large, multinucleated cell that secretes bone-degrading enzymes in the processes of normal bone remodeling and pathological bone loss. Osteoclasts are derived from macrophages."], "t": []}, {"i": "MESH:D010010", "l": "Osteoclasts", "d": [], "t": []}, {"i": "SNOMEDCT:27770000", "l": "", "d": [], "t": []}], "preferred_name": "Osteoclasts", "taxa": []}
{"type": "biolink:Cell", "ic": 58.75759648419927, "identifiers": [{"i": "UMLS:C1514029", "l": "Neoplastic Epithelial Cell with Intracytoplasmic Mucin", "d": [], "t": []}, {"i": "NCIT:C37116", "l": "Neoplastic Epithelial Cell with Intracytoplasmic Mucin", "d": [], "t": []}], "preferred_name": "Neoplastic Epithelial Cell with Intracytoplasmic Mucin", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4079001", "l": "cervical dorsal root ganglion endothelin-1 neuron", "d": ["A sensory neuron whose soma is located in the cervical dorsal root ganglion and that expresses endothelin-1 (EDN1). In rat DRG, EDN1 immunoreactivity has been detected in a subset of neuron somata (Giaid et al. 1989, PMID:2678100). Endothelin-1 acts as an endogenous pain mediator, sensitizing nociceptors through activation of ETA and ETB receptors, and these neurons are implicated in vascular pain signalling. EDN1-expressing DRG neurons have been characterized in rat; their prevalence and properties in human DRG remain to be systematically determined, as EDN1 is not yet represented in human DRG single-cell transcriptomic datasets."], "t": []}], "preferred_name": "cervical dorsal root ganglion endothelin-1 neuron", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1440350", "l": "Cell negative for CD3 antigen and positive for CD7 antigen", "d": [], "t": []}, {"i": "SNOMEDCT:1373182008", "l": "", "d": [], "t": []}], "preferred_name": "Cell negative for CD3 antigen and positive for CD7 antigen", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:1000364", "l": "transitional myocyte of anterior internodal tract", "d": ["A transitional myocyte that is part of the anterior internodal tract."], "t": []}, {"i": "UMLS:C2336229", "l": "Transitional myocyte of anterior internodal tract", "d": [], "t": []}], "preferred_name": "transitional myocyte of anterior internodal tract", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5702864", "l": "Anti-CD19 CAR T Cells AT101", "d": [], "t": []}, {"i": "NCIT:C187300", "l": "Anti-CD19 CAR T Cells AT101", "d": ["A preparation of T-lymphocytes that have been genetically modified to express a chimeric antigen receptor (CAR) targeting the tumor-associated antigen (TAA) CD19 and containing, as of yet undisclosed co-stimulatory signaling domains, with potential immunostimulating and antineoplastic activities. Upon administration, anti-CD19 CAR T cells AT101 recognize and bind to CD19-expressing tumor cells, thereby inducing selective toxicity in CD19-expressing tumor cells. CD19 antigen is a B-cell specific cell surface antigen expressed in all B-cell lineage malignancies."], "t": []}], "preferred_name": "Anti-CD19 CAR T Cells AT101", "taxa": []}
{"type": "biolink:Cell", "ic": 92.76600187037766, "identifiers": [{"i": "UMLS:C1519322", "l": "Signet Ring Stromal Cell", "d": [], "t": []}, {"i": "NCIT:C36902", "l": "Signet Ring Stromal Cell", "d": [], "t": []}], "preferred_name": "Signet Ring Stromal Cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C2335679", "l": "Diploid germ cell", "d": [], "t": []}], "preferred_name": "Diploid germ cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5155168", "l": "Blasts | Cerebral spinal fluid | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Blasts | Cerebral spinal fluid | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": 85.53200374075534, "identifiers": [{"i": "UMLS:C1513933", "l": "Neoplastic Myeloblast with Basophilic Cytoplasm", "d": [], "t": []}, {"i": "NCIT:C37066", "l": "Neoplastic Myeloblast with Basophilic Cytoplasm", "d": [], "t": []}], "preferred_name": "Neoplastic Myeloblast with Basophilic Cytoplasm", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5177778", "l": "Polymorphonuclear cells | Body fluid | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Polymorphonuclear cells | Body fluid | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1267937", "l": "Lymphocyte positive for CD49B antigen", "d": [], "t": []}, {"i": "SNOMEDCT:117380001", "l": "", "d": [], "t": []}], "preferred_name": "Lymphocyte positive for CD49B antigen", "taxa": []}
{"type": "biolink:Cell", "ic": 92.76600187037766, "identifiers": [{"i": "CL:1000548", "l": "kidney outer medulla collecting duct epithelial cell", "d": ["An epithelial cell that is part of an outer medullary collecting duct."], "t": []}], "preferred_name": "kidney outer medulla collecting duct epithelial cell", "taxa": []}
{"type": "biolink:Cell", "ic": 73.613037951824, "identifiers": [{"i": "CL:0000239", "l": "brush border epithelial cell", "d": ["An epithelial cell characterized by the presence of a brush border on its apical surface, which increases the surface area for absorption."], "t": []}], "preferred_name": "brush border epithelial cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1440256", "l": "CD11b+CD14+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:1372970006", "l": "", "d": [], "t": []}], "preferred_name": "CD11b+CD14+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1519741", "l": "UC06", "d": [], "t": []}, {"i": "NCIT:C20306", "l": "UC06", "d": ["Provider: University of California, San Francisco, CA. Information from provider and not independently verified by NIH: Cells have normal morphology and a normal female karyotype. Cells differentiate in vitro into all three germ layers; Cells are positive for cell marker Oct-4, SSEA-3, SSEA-4, and alkaline phosphatase; Cells are negative for SSEA-1; Cells will be available only for collaboration once the MTA is completed. This cell line meets the criteria for the use of human embryonic stem cells by federally funded researchers."], "t": []}], "preferred_name": "UC06", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1280428", "l": "Entire delta Cell of islet", "d": [], "t": []}, {"i": "SNOMEDCT:247952004", "l": "", "d": [], "t": []}], "preferred_name": "Entire delta Cell of islet", "taxa": []}
{"type": "biolink:Cell", "ic": 53.43603105676945, "identifiers": [{"i": "UMLS:C1514110", "l": "Neoplastic T-Lymphocyte and Neoplastic Natural Killer Cell", "d": [], "t": []}, {"i": "NCIT:C39566", "l": "Neoplastic T-Lymphocyte and Neoplastic Natural Killer Cell", "d": [], "t": []}], "preferred_name": "Neoplastic T-Lymphocyte and Neoplastic Natural Killer Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 81.34422831136257, "identifiers": [{"i": "UMLS:C1708897", "l": "Malignant Ovoid to Spindle-Shaped Fibrohistiocytic Cell", "d": [], "t": []}, {"i": "NCIT:C49067", "l": "Malignant Ovoid to Spindle-Shaped Fibrohistiocytic Cell", "d": [], "t": []}], "preferred_name": "Malignant Ovoid to Spindle-Shaped Fibrohistiocytic Cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1284809", "l": "Entire supporting cell of organ of Corti", "d": [], "t": []}, {"i": "SNOMEDCT:362573009", "l": "", "d": [], "t": []}], "preferred_name": "Entire supporting cell of organ of Corti", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4740237", "l": "Spermatozoa.abnormal principal pieces", "d": [], "t": []}], "preferred_name": "Spermatozoa.abnormal principal pieces", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4030011", "l": "epithelial cell of proximal tubule segment 3", "d": ["A brush border cell that is part of segment 3 (S3) of the proximal tubule epithelium, which extends from the medullary rays of the renal cortex into the outer medulla."], "t": []}], "preferred_name": "epithelial cell of proximal tubule segment 3", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0682527", "l": "hybrid cell line", "d": [], "t": []}], "preferred_name": "hybrid cell line", "taxa": []}
{"type": "biolink:Cell", "ic": 70.01422862627324, "identifiers": [{"i": "CL:0000813", "l": "memory T cell", "d": ["A long-lived, antigen-experienced T cell that has acquired a memory phenotype including distinct surface markers and the ability to differentiate into an effector T cell upon antigen reexposure."], "t": []}, {"i": "UMLS:C0682639", "l": "Memory T Cells", "d": [], "t": []}, {"i": "NCIT:C104082", "l": "Memory T-Lymphocyte", "d": ["A mature T-lymphocyte that has encountered its cognate antigen and is primed to reproduce and elicit a stronger immune response upon a second encounter with the antigen. These cells are characterized by the presence CD45R0."], "t": []}, {"i": "MESH:D000091246", "l": "Memory T Cells", "d": [], "t": []}], "preferred_name": "memory T cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C0229631", "l": "Siderocyte", "d": [], "t": []}, {"i": "NCIT:C206316", "l": "Siderocyte", "d": ["An abnormal erythrocyte containing dark-staining granules composed of ferric iron."], "t": []}, {"i": "SNOMEDCT:61837008", "l": "", "d": [], "t": []}], "preferred_name": "Siderocyte", "taxa": []}
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{"type": "biolink:Cell", "ic": 92.76600187037766, "identifiers": [{"i": "CL:0000853", "l": "olfactory epithelial supporting cell", "d": ["Olfactory epithelial support cell is a columnar cell that extends from the epithelial free margin to the basement membrane of the olfactory epithelium. This cell type has a large, vertically, elongate, euchromatic nucleus, along with other nuclei, forms a layer superficial to the cell body of the receptor cell; sends long somewhat irregular microvilli into the mucus layer; at the base, with expanded end-feet containing numerous lamellated dense bodies resembling lipofuscin of neurons."], "t": []}, {"i": "UMLS:C1179113", "l": "Supporting cell of olfactory epithelium", "d": [], "t": []}], "preferred_name": "olfactory epithelial supporting cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5557384", "l": "Autologous Anti-CD19/CD20 CAR-T Cells KITE-363", "d": [], "t": []}, {"i": "NCIT:C181943", "l": "Autologous Anti-CD19/CD20 CAR-T Cells KITE-363", "d": ["A preparation of autologous T-lymphocytes engineered to express a chimeric antigen receptor (CAR) specific for the two tumor-associated antigens (TAAs) cluster of differentiation 19 (CD19) and CD20, with potential immunostimulating and antineoplastic activities. Upon administration, the autologous anti-CD19/CD20 CAR-T cells KITE-363 target and bind to CD19- and CD20-expressing tumor B-cells. This induces selective toxicity in tumor B-cells expressing these TAAs. Both CD19 and CD20 are B-cell-specific cell surface antigens overexpressed in B-cell lineage malignancies. Targeting both CD19 and CD20 may prevent tumor cell antigen escape and relapse."], "t": []}], "preferred_name": "Autologous Anti-CD19/CD20 CAR-T Cells KITE-363", "taxa": []}
{"type": "biolink:Cell", "ic": 83.63771255585968, "identifiers": [{"i": "UMLS:C1709676", "l": "Primitive Skeletal Spindle Cell", "d": [], "t": []}, {"i": "NCIT:C49171", "l": "Primitive Skeletal Spindle Cell", "d": [], "t": []}], "preferred_name": "Primitive Skeletal Spindle Cell", "taxa": []}
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{"type": "biolink:Cell", "ic": 85.53200374075534, "identifiers": [{"i": "UMLS:C1515878", "l": "Activated B-Lymphocyte", "d": [], "t": []}, {"i": "NCIT:C38333", "l": "Activated B-Lymphocyte", "d": ["A white blood cell produced in the bone marrow that, due to contact with an antigen, able to proliferate and differentiate into B memory cells, antibody-secreting B-lymphocytes or plasma cells."], "t": []}], "preferred_name": "Activated B-Lymphocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4023160", "l": "cartwheel cell", "d": ["A neuron of the dorsal cochlear nucleus with spiny dendrites that receive input from the axons of granule cells and with axons that release GABA and glycine onto cartwheel, pyramidal and giant cell targets."], "t": []}], "preferred_name": "cartwheel cell", "taxa": []}
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{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1440418", "l": "Cells.t(9;22)(q22;q12.2)(NR4A3,EWSR1)", "d": [], "t": []}], "preferred_name": "Cells.t(9;22)(q22;q12.2)(NR4A3,EWSR1)", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5874380", "l": "Casgevy", "d": [], "t": []}], "preferred_name": "Casgevy", "taxa": []}
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{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "CL:0000770", "l": "band form basophil", "d": ["A late basophilic metamyelocyte in which the nucleus is in the form of a curved or coiled band, not having acquired the typical multilobar shape of the mature basophil."], "t": []}], "preferred_name": "band form basophil", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5783463", "l": "Antigen-presenting Cells-expressing HPV16 E6/E7/CD86/mbIL-2/mbIL-12 SQZ-eAPC-HPV", "d": [], "t": []}, {"i": "NCIT:C190037", "l": "Antigen-presenting Cells-expressing HPV16 E6/E7/CD86/mbIL-2/mbIL-12 SQZ-eAPC-HPV", "d": ["A preparation of antigen presenting cells (APCs) specific for human papillomavirus (HPV) type 16 E6 and E7 proteins, and engineered to express the costimulatory molecule CD86 and the membrane-bound cytokines interleukin-2 (mbIL-2) and interleukin-12 (mbIL-12), with potential immunomodulating and antineoplastic activities. Autologous peripheral blood mononuclear cells (PBMCs) are ex vivo engineered with five mRNA encoding for HPV 16 E6/E7 antigens, CD86, mbIL-2 and mbIL-12; the resulting APCs present the antigens in a major histocompatibility type I (MHC-I) manner. Upon administration of the APCs-expressing HPV16 E6/E7/CD86/mbIL-2/mbIL-12 SQZ-eAPC-HPV, these cells activate the immune system to mount a cytotoxic T-lymphocyte (CTL) immune response against tumor cells expressing HPV16 E6 and E7. The costimulatory molecule CD86 and the cytokines mbIL-2 and mbIL-12 further activate the immune system by promoting the secretion of interferon-gamma (IFNg), activating natural killer cells (NKs), and inducing CTL responses, further killing tumor cells. HPV16 E6 and E7 play an important role in the development of certain types of cancer."], "t": []}], "preferred_name": "Antigen-presenting Cells-expressing HPV16 E6/E7/CD86/mbIL-2/mbIL-12 SQZ-eAPC-HPV", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4304493", "l": "Population of all target cells in portion of fluid", "d": [], "t": []}, {"i": "SNOMEDCT:719695006", "l": "", "d": [], "t": []}], "preferred_name": "Population of all target cells in portion of fluid", "taxa": []}
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{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C3656577", "l": "CD158a+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:1372851002", "l": "", "d": [], "t": []}], "preferred_name": "CD158a+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4023108", "l": "oxytocin-secreting magnocellular cell", "d": ["A magnocellular neurosecretory cell that is capable of producing and secreting oxytocin."], "t": []}], "preferred_name": "oxytocin-secreting magnocellular cell", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "UMLS:C1513941", "l": "Neoplastic Clear Cell Oncocyte", "d": [], "t": []}, {"i": "NCIT:C36939", "l": "Neoplastic Clear Cell Oncocyte", "d": [], "t": []}], "preferred_name": "Neoplastic Clear Cell Oncocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 65.38113392682368, "identifiers": [{"i": "UMLS:C5785509", "l": "Cell Specimen", "d": [], "t": []}, {"i": "NCIT:C192998", "l": "Cell Specimen", "d": ["A biospecimen comprised of purified or partially-purified cells."], "t": []}], "preferred_name": "Cell Specimen", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0000869", "l": "tonsillar macrophage", "d": ["A gut-associated lymphoid tissue macrophage found in tonsils."], "t": []}], "preferred_name": "tonsillar macrophage", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5216260", "l": "Malignant cells|NCnc|Pt|CSF", "d": [], "t": []}], "preferred_name": "Malignant cells|NCnc|Pt|CSF", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C3899815", "l": "CD30 CAR-expressing Autologous T Lymphocytes", "d": [], "t": []}, {"i": "NCIT:C116738", "l": "CD30 CAR-expressing Autologous T Lymphocytes", "d": ["A preparation of autologous T-lymphocytes that have been genetically modified to express a chimeric antigen receptor (CAR) specific for the CD30 antigen, with potential immunostimulating and antineoplastic activities. Upon administration, the CD30 CAR-expressing autologous T-lymphocytes specifically recognize and bind to CD30-expressing tumor cells, resulting in tumor cell lysis. CD30, a cell surface receptor and a member of the tumor necrosis factor (TNF) receptor superfamily, is transiently expressed on activated lymphocytes and is constitutively expressed in hematologic malignancies."], "t": []}], "preferred_name": "CD30 CAR-expressing Autologous T Lymphocytes", "taxa": []}
{"type": "biolink:Cell", "ic": 92.76600187037766, "identifiers": [{"i": "CL:0000762", "l": "nucleated thrombocyte", "d": ["A nucleated blood cell involved in coagulation, typically seen in birds and other non-mammalian vertebrates."], "t": []}], "preferred_name": "nucleated thrombocyte", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5157304", "l": "CD138 cells | Blood | Cell markers", "d": [], "t": []}], "preferred_name": "CD138 cells | Blood | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1183184", "l": "Set of aminergic cells in ventral tegmental area [A10]", "d": [], "t": []}], "preferred_name": "Set of aminergic cells in ventral tegmental area [A10]", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5157235", "l": "CD10 blasts | Bone marrow | Cell markers", "d": [], "t": []}], "preferred_name": "CD10 blasts | Bone marrow | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": 39.116265193977014, "identifiers": [{"i": "CL:0000047", "l": "neural stem cell", "d": ["An undifferentiated neural cell that originates from the neuroectoderm and has the capacity both to perpetually self-renew without differentiating and to generate multiple central nervous system neuronal and glial cell types."], "t": []}, {"i": "UMLS:C1113654", "l": "Neural Stem Cells", "d": [], "t": []}, {"i": "NCIT:C12985", "l": "Neural Stem Cell", "d": ["A stem cell derived from embryonic sources or found in adult neural tissue. It has the capacity to generate all the multiple cell types found in the brain and spinal cord."], "t": []}, {"i": "MESH:D058953", "l": "Neural Stem Cells", "d": [], "t": []}], "preferred_name": "neural stem cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5380988", "l": "Cells.CD8.HLA-B8 CMV specific.CMV antigen stimulated CD107a+b expressing", "d": [], "t": []}], "preferred_name": "Cells.CD8.HLA-B8 CMV specific.CMV antigen stimulated CD107a+b expressing", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5978014", "l": "Epithelial cells | Synovial fluid | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Epithelial cells | Synovial fluid | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": 74.64805296934512, "identifiers": [{"i": "UMLS:C1711298", "l": "Malignant Chondrocyte", "d": [], "t": []}, {"i": "NCIT:C53478", "l": "Malignant Chondrocyte", "d": [], "t": []}], "preferred_name": "Malignant Chondrocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 92.76600187037766, "identifiers": [{"i": "CL:0000434", "l": "eccrine cell", "d": ["A secretory cell that discharges its product without loss of cytoplasm."], "t": []}], "preferred_name": "eccrine cell", "taxa": []}
{"type": "biolink:Cell", "ic": 84.83823963392128, "identifiers": [{"i": "UMLS:C1511569", "l": "CyThera ES Cell Line", "d": [], "t": []}, {"i": "NCIT:C20246", "l": "CyThera ES Cell Line", "d": [], "t": []}], "preferred_name": "CyThera ES Cell Line", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0002110", "l": "B220-low CD38-positive naive B cell", "d": ["A B220-low CD38-positive naive B cell is a CD38-positive naive B cell that has the phenotype B220-low, CD38-positive, surface IgD-positive, surface IgM-positive, and CD27-negative, that has not yet been activated by antigen in the periphery."], "t": []}], "preferred_name": "B220-low CD38-positive naive B cell", "taxa": []}
{"type": "biolink:Cell", "ic": 81.743421370964, "identifiers": [{"i": "UMLS:C1881911", "l": "Mucinous Tall Columnar Adenocarcinoma Cell", "d": [], "t": []}, {"i": "NCIT:C54690", "l": "Mucinous Tall Columnar Adenocarcinoma Cell", "d": [], "t": []}], "preferred_name": "Mucinous Tall Columnar Adenocarcinoma Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 82.16838616155795, "identifiers": [{"i": "UMLS:C1512330", "l": "Hallmark Cell", "d": [], "t": []}, {"i": "NCIT:C39679", "l": "Hallmark Cell", "d": [], "t": []}], "preferred_name": "Hallmark Cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0333838", "l": "Gaucher-like cell", "d": [], "t": []}, {"i": "SNOMEDCT:59870003", "l": "", "d": [], "t": []}], "preferred_name": "Gaucher-like cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C3484293", "l": "Basophils+Mast cells", "d": [], "t": []}], "preferred_name": "Basophils+Mast cells", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C3488038", "l": "human breast tumor cell", "d": [], "t": []}], "preferred_name": "human breast tumor cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5157435", "l": "CD3+CD4+ (T4 helper) cells | Blood | Cell markers", "d": [], "t": []}], "preferred_name": "CD3+CD4+ (T4 helper) cells | Blood | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1517640", "l": "KA40 cell line", "d": [], "t": []}, {"i": "NCIT:C20270", "l": "KA40", "d": ["Provider: Karolinska Institute, Stockholm, Sweden. No information from provider. This cell line meets the criteria for the use of human embryonic stem cells by federally funded researchers."], "t": []}], "preferred_name": "KA40 cell line", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "UMLS:C1512564", "l": "Hypogranular Promyelocyte", "d": [], "t": []}, {"i": "NCIT:C37074", "l": "Hypogranular Promyelocyte", "d": [], "t": []}], "preferred_name": "Hypogranular Promyelocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5418020", "l": "Autologous NKG2D CAR T-cells CYAD-02", "d": [], "t": []}, {"i": "NCIT:C173710", "l": "Autologous NKG2D CAR T-cells CYAD-02", "d": ["A preparation of autologous T-lymphocytes that have been genetically modified and transduced with a retroviral vector to co-express a chimeric antigen receptor (CAR) encoding human natural-killer group 2, member D receptor protein (NKG2D or KLRK1) with a short hairpin RNA (shRNA) targeting MHC class I chain-related protein A (MICA) and MICB, with potential immunostimulating and antineoplastic activities. Upon infusion back into the patient, autologous NKG2D CAR T-cells CYAD-02 specifically recognize and bind to tumor cells expressing NKG2D ligands, resulting in the lysis of NKG2D ligand-expressing tumor cells. In addition, CYAD-02 targets, binds to and kills NKG2D ligand expressing tumor-associated endothelial cells in the neovasculature and immunosuppressive cells, such as regulatory T-cells (Tregs) and myeloid-derived suppressor cells (MDSCs) in the tumor microenvironment (TME) that express NKG2D ligands. It also activates macrophages within the TME. Ligands for NKG2D, such as MICA, MICB, and members of the UL16-binding proteins (ULBP)/retinoic acid early transcript 1 (RAET1) family, are overexpressed on infected cells and most cancer cell types, but are not expressed on most normal, healthy cells. NKG2D, a dimeric, type II transmembrane protein expressed on human natural killer (NK) and certain T-cells, in association with the natural adaptive protein DAP10, promotes the elimination of NKG2D ligand-expressing cells. The shRNA downregulates the expression of MICA and MICB on the CAR-T cells, which increases in-vitro cell expansion. This may enhance their persistence and increase anti-tumor activity."], "t": []}], "preferred_name": "Autologous NKG2D CAR T-cells CYAD-02", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0002286", "l": "type II taste cell", "d": ["A taste receptor cell that has a short microvilli, a projecting apical region, a large rounded nucleus, and expresses taste chemoreceptors thus making them the transducing cell for taste qualities."], "t": []}, {"i": "UMLS:C1179136", "l": "Type II taste bud cell", "d": [], "t": []}], "preferred_name": "type II taste cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C4724868", "l": "Autologous EGFRt/BCMA-41BBz-targeted CAR T Cells", "d": [], "t": []}, {"i": "NCIT:C148168", "l": "Autologous EGFRt/BCMA-41BBz-targeted CAR T Cells", "d": ["A preparation of autologous T-lymphocytes transduced with a retroviral vector expressing a chimeric antigen receptor (CAR) specific for the tumor-associated antigen (TAA) human B-cell maturation antigen (BCMA; tumor necrosis factor receptor superfamily member 17; TNFRSF17) fused to the co-stimulatory domain of 4-1BB (CD137) and the CD3-zeta (CD3z) T-cell signaling domain, and a truncated form of the human epidermal growth factor receptor (EGFRt), with potential immunostimulating and antineoplastic activities. Upon intravenous administration, autologous EGFRt/BCMA-41BBz-targeted CAR T cells are directed to, and induce selective toxicity in, BCMA-expressing tumor cells. Devoid of both ligand-binding domains and tyrosine kinase activity, the expressed EGFRt facilitates in vivo detection of the administered, transduced T-cells and, if the administered T-cells cause unacceptable side effects, can promote elimination of those cells through a cetuximab-induced antibody-dependent cellular cytotoxicity (ADCC) response. The 4-1BB costimulatory signaling domain enhances both proliferation of T-cells and antitumor activity. BCMA, a receptor for both a proliferation-inducing ligand (APRIL) and B-cell activating factor (BAFF), is a member of the tumor necrosis factor receptor superfamily (TNFRSF) and plays a key role in plasma cell survival. BCMA is found on the surfaces of plasma cells and is overexpressed on malignant plasma cells."], "t": []}], "preferred_name": "Autologous EGFRt/BCMA-41BBz-targeted CAR T Cells", "taxa": []}
{"type": "biolink:Cell", "ic": 75.38868324457971, "identifiers": [{"i": "CL:0002428", "l": "double-positive blast", "d": ["A double-positive thymocyte that is large (i.e. has a high forward scatter signal in flow cytometry) and is actively proliferating."], "t": []}], "preferred_name": "double-positive blast", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5184398", "l": "Unidentified cells | Pericardial fluid | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Unidentified cells | Pericardial fluid | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1956422", "l": "Cancer Stem Cells", "d": [], "t": []}, {"i": "NCIT:C68706", "l": "Cancer Stem Cell", "d": ["A malignant cell which may derive from mutations in normal stem cells. Cancer stem cells proliferate and give rise to other malignant cells. They may be present in very small numbers in the tumor and may not be present in all tumors. Many investigators believe that cancer stem cells cause relapse of the tumor and that novel cancer therapies should specifically target those cells."], "t": []}], "preferred_name": "Cancer Stem Cells", "taxa": []}
{"type": "biolink:Cell", "ic": 56.00878421882713, "identifiers": [{"i": "UMLS:C1512631", "l": "Immature B-Lymphocyte", "d": [], "t": []}, {"i": "NCIT:C32766", "l": "Immature B-Lymphocyte", "d": ["A B-lymphocyte derived from a Pre B lymphocyte. It develops in bone marrow then exit via the central sinus. It goes through the vascular system to the spleen. It does not proliferate and differentiate in response to antigen, but instead responds to antigen by negative selection resulting in subsequent immune system tolerance to that antigen."], "t": []}, {"i": "MESH:D054448", "l": "Precursor Cells, B-Lymphoid", "d": [], "t": []}], "preferred_name": "Immature B-Lymphocyte", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1183180", "l": "Set of aminergic cells in compact part of substantia nigra [A9]", "d": [], "t": []}], "preferred_name": "Set of aminergic cells in compact part of substantia nigra [A9]", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0333841", "l": "Hunter-Hurler cell", "d": [], "t": []}, {"i": "SNOMEDCT:84702007", "l": "", "d": [], "t": []}], "preferred_name": "Hunter-Hurler cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0000180", "l": "estradiol secreting cell", "d": ["A steroid hormone secreting cell that secretes estradiol."], "t": []}], "preferred_name": "estradiol secreting cell", "taxa": []}
{"type": "biolink:Cell", "ic": 75.08236434612573, "identifiers": [{"i": "UMLS:C1709200", "l": "Neoplastic Small to Medium-Sized B-Lymphocyte Resembling a Centrocyte", "d": [], "t": []}, {"i": "NCIT:C45310", "l": "Neoplastic Small to Medium-Sized B-Lymphocyte Resembling a Centrocyte", "d": [], "t": []}], "preferred_name": "Neoplastic Small to Medium-Sized B-Lymphocyte Resembling a Centrocyte", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4722695", "l": "ACTolog IMA101", "d": [], "t": []}], "preferred_name": "ACTolog IMA101", "taxa": []}
{"type": "biolink:Cell", "ic": 85.53200374075534, "identifiers": [{"i": "UMLS:C1879717", "l": "Apocrine Carcinoma Cell", "d": [], "t": []}, {"i": "NCIT:C36908", "l": "Apocrine Carcinoma Cell", "d": [], "t": []}], "preferred_name": "Apocrine Carcinoma Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4307094", "l": "COP NN_1 C1ql1 committed oligodendrocyte precursor (Mmus)", "d": ["A committed oligodendrocyte precursor of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Gpr17 (Mmus), Bgn (Mmus), Gstp1 (Mmus), C1ql1 (Mmus). It is distinguished from other COP NN_1 cells by expression of C1ql1, Gstp1. These cells are located in the brain . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5274 COP NN_1."], "t": []}], "preferred_name": "COP NN_1 C1ql1 committed oligodendrocyte precursor (Mmus)", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0002151", "l": "late promyelocyte", "d": ["A promyelocyte that is considerably smaller, with more condensed chromatin, and nucleoli are no longer conspicuous."], "t": []}, {"i": "UMLS:C2340471", "l": "Late promyelocyte", "d": [], "t": []}], "preferred_name": "late promyelocyte", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4263663", "l": "B-cell CD27 & IgD subsets", "d": [], "t": []}], "preferred_name": "B-cell CD27 & IgD subsets", "taxa": []}
{"type": "biolink:Cell", "ic": 82.62268137420203, "identifiers": [{"i": "CL:1001601", "l": "adrenal gland glandular cell", "d": ["Hormone secreting cell located in the cortex of adrenal gland. Glandular cells in the adrenal cortex secrete mineralocorticoids, glucocorticoids and androgens."], "t": []}], "preferred_name": "adrenal gland glandular cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:1000323", "l": "pyloric gastric gland goblet cell", "d": ["A goblet cell that is part of the epithelium of pyloric gland."], "t": []}], "preferred_name": "pyloric gastric gland goblet cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C2334745", "l": "Astroblast", "d": [], "t": []}], "preferred_name": "Astroblast", "taxa": []}
{"type": "biolink:Cell", "ic": 69.87704306295657, "identifiers": [{"i": "CL:0008034", "l": "mural cell", "d": ["Mural cells are pericytes and the vascular smooth muscle cells (vSMCs) of the microcirculation."], "t": []}], "preferred_name": "mural cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5219006", "l": "Erythrocytes|NCnc|Urine", "d": [], "t": []}], "preferred_name": "Erythrocytes|NCnc|Urine", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1440336", "l": "CD6+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:1372913001", "l": "", "d": [], "t": []}], "preferred_name": "CD6+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4277646", "l": "Place Cells", "d": [], "t": []}, {"i": "MESH:D000071037", "l": "Place Cells", "d": [], "t": []}], "preferred_name": "Place Cells", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5690234", "l": "Other cells | Amniotic fluid | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Other cells | Amniotic fluid | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": 86.30756602822301, "identifiers": [{"i": "CL:4300354", "l": "cerebellar granule cell (Mmus)", "d": ["A cerebellar granule cell of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Gabra6 (Mmus), Ror1 (Mmus). Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Subclass:314 CB Granule Glut."], "t": []}], "preferred_name": "cerebellar granule cell (Mmus)", "taxa": []}
{"type": "biolink:Cell", "ic": 79.07356789860069, "identifiers": [{"i": "UMLS:C1514201", "l": "Polygonal Adenocarcinoma Cell with Eosinophilic Cytoplasm", "d": [], "t": []}, {"i": "NCIT:C36850", "l": "Polygonal Adenocarcinoma Cell with Eosinophilic Cytoplasm", "d": [], "t": []}], "preferred_name": "Polygonal Adenocarcinoma Cell with Eosinophilic Cytoplasm", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C3828741", "l": "NY-ESO-1(157-165) Peptide-pulsed Autologous Dendritic Cell Vaccine", "d": [], "t": []}, {"i": "NCIT:C114380", "l": "NY-ESO-1(157-165) Peptide-pulsed Autologous Dendritic Cell Vaccine", "d": ["A cell-based cancer vaccine composed of autologous dendritic cells (DCs) pulsed with a peptide derived from the tumor associated antigen human cancer-testis antigen NY-ESO-1 (NY-ESO-1(157-165)), with potential immunostimulatory and antineoplastic activities. Upon administration, the NY-ESO-1(157-165) peptide-pulsed autologous dendritic cell vaccine may stimulate the immune system to mount both an anti-tumoral cytotoxic T-lymphocyte (CTL)- and an antibody-mediated immune response against NY-ESO-1-expressing tumor cells, which may result in tumor cell lysis. NY-ESO-1 is expressed both in normal testes and on the surfaces of various tumor cells, and plays a key role in tumor cell proliferation and survival."], "t": []}], "preferred_name": "NY-ESO-1(157-165) Peptide-pulsed Autologous Dendritic Cell Vaccine", "taxa": []}
{"type": "biolink:Cell", "ic": 73.98236851641934, "identifiers": [{"i": "CL:0000980", "l": "plasmablast", "d": ["An activated mature (naive or memory) B cell that is secreting immunoglobulin, typified by being CD27-positive, CD38-positive, CD138-negative."], "t": []}], "preferred_name": "plasmablast", "taxa": []}
{"type": "biolink:Cell", "ic": 88.20185721311867, "identifiers": [{"i": "CL:0002012", "l": "Kit-low proerythroblast", "d": ["A proerythoblast that is Kit-low, Lyg76-positive, and CD71-positive."], "t": []}], "preferred_name": "Kit-low proerythroblast", "taxa": []}
{"type": "biolink:Cell", "ic": 92.76600187037766, "identifiers": [{"i": "CL:4023000", "l": "beta motor neuron", "d": ["A motor neuron that innervates both intrafusal and extrafusal muscle fibers. Low abundancy. They control both muscle contraction and responsiveness of the sensory feedback from muscle spindles."], "t": []}], "preferred_name": "beta motor neuron", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5181368", "l": "Spermatozoa Progressive | Semen | Fertility testing", "d": [], "t": []}], "preferred_name": "Spermatozoa Progressive | Semen | Fertility testing", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5556546", "l": "Autologous CD19-CD8-CD28-CAR-mbIL15-HER1t T Cells", "d": [], "t": []}, {"i": "NCIT:C180672", "l": "Autologous CD19-CD8-CD28-CAR-mbIL15-HER1t T Cells", "d": ["A preparation of autologous T-lymphocytes, that have been electroporated ex vivo with sleeping beauty (SB)-derived DNA plasmids encoding a chimeric antigen receptor (CAR) targeting the tumor-associated antigen (TAA) cluster of differentiation 19 (CD19) that is linked to the co-stimulatory molecules T-cell surface glycoproteins CD8 and CD28 and co-expressed with a chimeric membrane-bound fusion protein comprised of interleukin-15 (IL-15) fused to IL-15 receptor (mbIL15) and a safety/kill switch composed of a truncated form of the human epidermal growth factor receptor (ErbB1t; EGFR)(HER1t), with potential immunostimulating and antineoplastic activities. Upon reintroduction of the autologous CD19-CD8-CD28-CAR-mbIL15-HER1t T cells into the patient, the T-cells target and bind to CD19-expressing tumor cells, thereby inducing selective toxicity in CD19-expressing tumor cells. CD19 is a B-cell specific cell surface antigen overexpressed in all B-cell lineage malignancies.  HER1t can promote selective elimination of the CAR-T cells through cetuximab-induced antibody-dependent cellular cytotoxicity (ADCC) and complement-dependent cytotoxicity (CDC). IL-15 is a pro-survival cytokine that is required for the maintenance of long-lived CD8+ memory T-cells and the use of mbIL15 preserves T stem-cell memory (TSCM) through sustained IL-15 signaling, improves T-cell persistence and potentiates the immune response against tumor cells. The SB system permits electroporation of the CAR, the IL-15 fusion variant and safety switch transgenes into T-cells without the need for viral vectors and accelerates the manufacturing process."], "t": []}], "preferred_name": "Autologous CD19-CD8-CD28-CAR-mbIL15-HER1t T Cells", "taxa": []}
{"type": "biolink:Cell", "ic": 90.871710685482, "identifiers": [{"i": "UMLS:C1513754", "l": "Multivacuolated Brown Fat Cell", "d": [], "t": []}, {"i": "NCIT:C36968", "l": "Multivacuolated Brown Fat Cell", "d": [], "t": []}], "preferred_name": "Multivacuolated Brown Fat Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 84.21065366064373, "identifiers": [{"i": "UMLS:C1513742", "l": "Multilobated Neoplastic B-Lymphocyte", "d": [], "t": []}, {"i": "NCIT:C37169", "l": "Multilobated Neoplastic B-Lymphocyte", "d": [], "t": []}], "preferred_name": "Multilobated Neoplastic B-Lymphocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0008053", "l": "circumventricular organ capillary endothelial cell", "d": ["A capillary endothelial cell that is part of the circumventricular organs (CVOs), characterized by fenestrations that facilitate selective permeability to molecules, distinguishing it from the non-fenestrated endothelial cells of the blood-brain barrier. This cell is integral to the unique vascular structure of CVOs, which lack a traditional blood-brain barrier. It enables bidirectional exchange of polar molecules between blood and neural tissue, supporting neuroendocrine signaling, fluid balance, and immune responses. It is marked by the expression of PLVAP, a component of the fenestral diaphragm, in both rodents and humans."], "t": []}], "preferred_name": "circumventricular organ capillary endothelial cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1267888", "l": "Lymphocyte positive for both CD19 antigen and surface lambda immunoglobulin light chain", "d": [], "t": []}, {"i": "SNOMEDCT:117564007", "l": "", "d": [], "t": []}], "preferred_name": "Lymphocyte positive for both CD19 antigen and surface lambda immunoglobulin light chain", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5170919", "l": "Leukocytes | Blood product unit | Blood | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Leukocytes | Blood product unit | Blood | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5170939", "l": "Leukocytes | Sputum | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Leukocytes | Sputum | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4733590", "l": "high efficiency killing T cells", "d": [], "t": []}], "preferred_name": "high efficiency killing T cells", "taxa": []}
{"type": "biolink:Cell", "ic": 81.34422831136257, "identifiers": [{"i": "CL:0005010", "l": "renal intercalated cell", "d": ["A cuboidal epithelial cell of the kidney that regulates acid/base balance."], "t": []}], "preferred_name": "renal intercalated cell", "taxa": []}
{"type": "biolink:Cell", "ic": 79.35380886648232, "identifiers": [{"i": "CL:0000465", "l": "cardioblast (sensu Arthropoda)", "d": ["A precursor of the cells that form the dorsal vessel of arthropods."], "t": []}], "preferred_name": "cardioblast (sensu Arthropoda)", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:2000057", "l": "femoral osteoblast", "d": ["Any osteoblast that is part of a femur."], "t": []}], "preferred_name": "femoral osteoblast", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1444184", "l": "Entire cleidoic ovum", "d": [], "t": []}], "preferred_name": "Entire cleidoic ovum", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1717943", "l": "Immunodeficiency markers", "d": [], "t": []}], "preferred_name": "Immunodeficiency markers", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0002586", "l": "retinal pigment epithelial cell", "d": ["An epithelial cell of the retinal pigmented epithelium."], "t": []}, {"i": "UMLS:C2330894", "l": "Retinal pigment epithelial cell", "d": [], "t": []}], "preferred_name": "retinal pigment epithelial cell", "taxa": []}
{"type": "biolink:Cell", "ic": 90.871710685482, "identifiers": [{"i": "CL:1000147", "l": "cardiac valve cell", "d": ["A cell that is part of a cardiac valve."], "t": []}], "preferred_name": "cardiac valve cell", "taxa": []}
{"type": "biolink:Cell", "ic": 80.61184433509295, "identifiers": [{"i": "UMLS:C1517715", "l": "Lacunar Reed-Sternberg Cell", "d": [], "t": []}, {"i": "NCIT:C37023", "l": "Lacunar Reed-Sternberg Cell", "d": [], "t": []}], "preferred_name": "Lacunar Reed-Sternberg Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 88.20185721311867, "identifiers": [{"i": "CL:1000601", "l": "ureteral cell", "d": ["Any cell that is part of some ureter."], "t": []}], "preferred_name": "ureteral cell", "taxa": []}
{"type": "biolink:Cell", "ic": 92.76600187037766, "identifiers": [{"i": "CL:4033039", "l": "lung resident memory CD8-positive, alpha-beta T cell", "d": ["An alpha-beta CD8 T cell that resides in the lung."], "t": []}], "preferred_name": "lung resident memory CD8-positive, alpha-beta T cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5556488", "l": "Zamtocabtagene autoleucel", "d": [], "t": []}], "preferred_name": "Zamtocabtagene autoleucel", "taxa": []}
{"type": "biolink:Cell", "ic": 83.11065783093733, "identifiers": [{"i": "UMLS:C1515408", "l": "Therapeutic Tumor Infiltrating Lymphocytes", "d": [], "t": []}, {"i": "NCIT:C28699", "l": "Therapeutic Tumor Infiltrating Lymphocytes", "d": ["A preparation of cells, consisting of autologous tumor infiltrating lymphocytes, that are manipulated in vitro and, upon administration in vivo, re-infiltrate the tumor to initiate tumor cell lysis. In vitro, therapeutic tumor-infiltrating lymphocytes (TILs) are isolated from tumor tissue and cultured with lymphokines such as interleukin-2; the therapeutic TILs are then infused into the patient, where, after re-infiltration of the tumor, they may induce lysis of tumor cells and tumor regression.  The use of therapeutic TILs is considered a form of adoptive immunotherapy."], "t": []}], "preferred_name": "Therapeutic Tumor Infiltrating Lymphocytes", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "MESH:D033761", "l": "Spores, Protozoan", "d": [], "t": []}], "preferred_name": "Spores, Protozoan", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0229541", "l": "Pituitary chromophobe cell", "d": [], "t": []}, {"i": "SNOMEDCT:27186004", "l": "", "d": [], "t": []}], "preferred_name": "Pituitary chromophobe cell", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "CL:0008042", "l": "tanycyte of subfornical organ", "d": ["A tanycyte of the subfornical organ (SFO).  These cells extend long and slender fibers extending from their cell bodies in the ependyma toward fenestrated capillaries associated with the SFO, where they form a dense network surrounding these capillaries."], "t": []}], "preferred_name": "tanycyte of subfornical organ", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5708695", "l": "Allogeneic Anti-CD19/CD22 CAR-BBz T-cells", "d": [], "t": []}, {"i": "NCIT:C189702", "l": "Allogeneic Anti-CD19/CD22 CAR-BBz T-cells", "d": ["A preparation of allogeneic T-lymphocytes that have been transduced with a bivalent lentiviral vector encoding a chimeric antigen receptor (CAR) targeting the two tumor-associated antigens (TAAs) CD19 and CD22, linked to the co-stimulatory domain 4-1BB (CD137) coupled to the zeta chain of the TCR/CD3 complex (TCRzeta; CD247; CD3zeta), with potential immunostimulating and antineoplastic activities. Upon administration, the allogeneic anti-CD19/CD22 CAR-BBz T-cells bind to and induce selective toxicity in tumor cells expressing CD19 and CD22. CD19 and CD22, both transmembrane phosphoglycoproteins expressed on the surface of cells in the B lineage, are often overexpressed on malignant B-cells. By simultaneously targeting two B-cell antigens, this preparation may minimize relapse due to single antigen loss in patients with B-cell malignancies."], "t": []}], "preferred_name": "Allogeneic Anti-CD19/CD22 CAR-BBz T-cells", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C4525956", "l": "LN 145", "d": [], "t": []}, {"i": "NCIT:C135634", "l": "Autologous Tumor Infiltrating Lymphocytes LN-145", "d": ["A proprietary preparation of autologous tumor infiltrating lymphocytes (TILs), with potential immunomodulating activity. The autologous TILs are isolated from an autologous tumor sample and expanded ex vivo in the presence of interleukin-2 (IL-2). Upon infusion of the autologous TILs LN-145 back into the patient, the cells specifically recognize, target and kill the patient's tumor cells."], "t": []}], "preferred_name": "LN 145", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4033068", "l": "cycling B cell", "d": ["A(n) B cell that is cycling."], "t": []}], "preferred_name": "cycling B cell", "taxa": []}
{"type": "biolink:Cell", "ic": 76.78008365410358, "identifiers": [{"i": "UMLS:C1518995", "l": "Peripheral B-Lymphocyte of Inner Mantle Zone", "d": [], "t": []}, {"i": "NCIT:C38332", "l": "Peripheral B-Lymphocyte of Inner Mantle Zone", "d": [], "t": []}], "preferred_name": "Peripheral B-Lymphocyte of Inner Mantle Zone", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C6063215", "l": "CD16+CD57+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:1372972003", "l": "", "d": [], "t": []}], "preferred_name": "CD16+CD57+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": 86.30756602822301, "identifiers": [{"i": "CL:0000061", "l": "cementoblast", "d": ["Skeletogenic cell that produces cementum (a bony substance that covers the root of a tooth), is part of the odontogenic papilla, and develops from a precementoblast cell."], "t": []}], "preferred_name": "cementoblast", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5706336", "l": "an autologous Chimeric Antigen Receptors (CAR) T-cell therapy expressing CD19/CD20 bi-specific CAR", "d": [], "t": []}], "preferred_name": "an autologous Chimeric Antigen Receptors (CAR) T-cell therapy expressing CD19/CD20 bi-specific CAR", "taxa": []}
{"type": "biolink:Cell", "ic": 90.871710685482, "identifiers": [{"i": "CL:0000631", "l": "labyrinth supporting cell", "d": ["Cells forming a framework supporting the organ of Corti. Specific cells are those of Claudius, Deiters and Hensen."], "t": []}, {"i": "UMLS:C0022891", "l": "Labyrinth Supporting Cells", "d": [], "t": []}, {"i": "NCIT:C12590", "l": "Supporting Cell of Organ of Corti", "d": ["One of the non-sensory cells that compose the supporting structures of the Organ of Corti."], "t": []}, {"i": "NCIT:C33240", "l": "Outer Supporting Cell", "d": ["A cell forming a cup for the outer hair cell of the Organ of Corti. The supporting cell sends out a narrow filament that angles towards the base of the cochlea. The structure is such that the supporting cell touches the outer hair cell only at the top and bottom."], "t": []}, {"i": "MESH:D007760", "l": "Labyrinth Supporting Cells", "d": [], "t": []}, {"i": "SNOMEDCT:28199004", "l": "", "d": [], "t": []}], "preferred_name": "labyrinth supporting cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0333832", "l": "Tart cell", "d": [], "t": []}, {"i": "SNOMEDCT:26819005", "l": "", "d": [], "t": []}], "preferred_name": "Tart cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0009083", "l": "rearranging double negative thymocyte (Homo sapiens)", "d": ["The human equivalent of a DN4 thymocyte."], "t": []}], "preferred_name": "rearranging double negative thymocyte (Homo sapiens)", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "CL:4033076", "l": "cycling macrophage", "d": ["A(n) macrophage that is cycling."], "t": []}], "preferred_name": "cycling macrophage", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5670750", "l": "Autologous MUC1-activated T-cells", "d": [], "t": []}, {"i": "NCIT:C186784", "l": "Autologous MUC1-activated T-cells", "d": ["A preparation of autologous T-lymphocytes that have been activated against the tumor associated antigen (TAA) mucin-1 (MUC1), with potential immunomodulating and antineoplastic activities. Upon re-introduction into the patient, autologous MUC1-activated T-cells specifically recognize and induce selective toxicity in MUC1-expressing tumor cells. MUC1, a glycoprotein overexpressed on the surface of a variety of cancer cells, plays a key role in tumor cell survival and proliferation."], "t": []}], "preferred_name": "Autologous MUC1-activated T-cells", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1507174", "l": "CD4+CD28+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:1373107000", "l": "", "d": [], "t": []}], "preferred_name": "CD4+CD28+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:1000373", "l": "transitional myocyte of ventricular part of atrioventricular bundle", "d": ["A transitional myocyte that is part of the ventricular part of atrioventricular bundle."], "t": []}, {"i": "UMLS:C2322913", "l": "Transitional myocyte of ventricular part of atrioventricular bundle", "d": [], "t": []}], "preferred_name": "transitional myocyte of ventricular part of atrioventricular bundle", "taxa": []}
{"type": "biolink:Cell", "ic": 85.53200374075534, "identifiers": [{"i": "UMLS:C5908900", "l": "Therapeutic Allogeneic Hematopoietic Stem Cells", "d": [], "t": []}, {"i": "NCIT:C203000", "l": "Therapeutic Allogeneic Hematopoietic Stem Cells", "d": ["Any preparation of allogeneic hematopoietic stem cells (HSCs)."], "t": []}], "preferred_name": "Therapeutic Allogeneic Hematopoietic Stem Cells", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "UMLS:C1708921", "l": "Malignant Thyrotroph Cell", "d": [], "t": []}, {"i": "NCIT:C45948", "l": "Malignant Thyrotroph Cell", "d": [], "t": []}], "preferred_name": "Malignant Thyrotroph Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1510962", "l": "Atypical Parabasal Cell", "d": [], "t": []}, {"i": "NCIT:C36787", "l": "Atypical Parabasal Cell", "d": [], "t": []}], "preferred_name": "Atypical Parabasal Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 81.743421370964, "identifiers": [{"i": "UMLS:C1518565", "l": "Olfactory Receptor Cells", "d": [], "t": []}, {"i": "NCIT:C12633", "l": "Olfactory Receptor Neuron", "d": ["A bipolar neuron located in the sensory epithelium within the nasal cavity that detects odor signal molecules and transmits olfactory information to the central nervous system."], "t": []}, {"i": "MESH:D018034", "l": "Olfactory Receptor Neurons", "d": [], "t": []}], "preferred_name": "Olfactory Receptor Cells", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5182506", "l": "Synovial cells | Body fluid | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Synovial cells | Body fluid | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": 73.04009684703995, "identifiers": [{"i": "UMLS:C1514099", "l": "Neoplastic Spindle-Shaped to Round Cell", "d": [], "t": []}, {"i": "NCIT:C37123", "l": "Neoplastic Spindle-Shaped to Round Cell", "d": [], "t": []}], "preferred_name": "Neoplastic Spindle-Shaped to Round Cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5888640", "l": "Amtagvi", "d": [], "t": []}], "preferred_name": "Amtagvi", "taxa": []}
{"type": "biolink:Cell", "ic": 86.30756602822301, "identifiers": [{"i": "CL:0000392", "l": "crystal cell", "d": ["A hemocyte that synthesizes and secretes melanins as part of the antimicrobial immune response. It is characterized morphologically by crystal inclusions of phenoloxidases in its cytoplasm, hence its name."], "t": []}, {"i": "UMLS:C0932034", "l": "Cell crystal", "d": [], "t": []}], "preferred_name": "crystal cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0020000", "l": "gut mesenchymal lymphoid tissue organizer cell", "d": ["A mesenchymal stromal cell found in the gut during development, and interacts with lymphoid tissue inducer (LTi) cells to drive secondary lymphoid organ formation (Prados et al., 2021). It expresses LTβR, PDGFRα, and VCAM, and upon activation secretes chemokines(e.g. CXCL13) and cytokines to organise lymphoid tissue architecture and recruit immune cells in both mice and humans (Denton el al., 2019; Elmentaite et al., 2021). As a multipotent progenitor, an mLTo cell differentiates into adult stromal subsets, including fibroblastic reticular cells (FRCs) (Prados et al., 2021), and its descendants persist in the adult gut-associated lymphoid tissues to maintain immune homeostasis(Denton el al., 2019; Lütge et al., 2021)."], "t": []}], "preferred_name": "gut mesenchymal lymphoid tissue organizer cell", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "UMLS:C1513729", "l": "Mucus-Secreting Cell", "d": [], "t": []}, {"i": "NCIT:C13142", "l": "Mucus-Secreting Cell", "d": ["It is the epithelium cell that produces mucin gel adherent to the mucosal surface. Mucus-secreting cells are widely distributed through the body. (NCI)"], "t": []}], "preferred_name": "Mucus-Secreting Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "CL:1000979", "l": "ureter smooth muscle cell", "d": ["Any smooth muscle cell that is part of some muscular coat of ureter."], "t": []}], "preferred_name": "ureter smooth muscle cell", "taxa": []}
{"type": "biolink:Cell", "ic": 88.20185721311867, "identifiers": [{"i": "UMLS:C1880955", "l": "Giant Melanoma Cell", "d": [], "t": []}, {"i": "NCIT:C62346", "l": "Giant Melanoma Cell", "d": [], "t": []}], "preferred_name": "Giant Melanoma Cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C2337350", "l": "Type III enteric ganglion neuron", "d": [], "t": []}], "preferred_name": "Type III enteric ganglion neuron", "taxa": []}
{"type": "biolink:Cell", "ic": 92.76600187037766, "identifiers": [{"i": "CL:0010001", "l": "stromal cell of bone marrow", "d": ["A stromal cell that is part_of a bone marrow."], "t": []}], "preferred_name": "stromal cell of bone marrow", "taxa": []}
{"type": "biolink:Cell", "ic": 74.37365206292206, "identifiers": [{"i": "CL:0002174", "l": "follicular cell of ovary", "d": ["A cell within the follicle of an ovary."], "t": []}, {"i": "UMLS:C1182635", "l": "Follicular cell of ovary", "d": [], "t": []}, {"i": "NCIT:C32620", "l": "Follicular Ovarian Cell", "d": ["A cell located in the epithelium of the ovarian follicles."], "t": []}], "preferred_name": "follicular cell of ovary", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0882819", "l": "CD22+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:732269007", "l": "", "d": [], "t": []}], "preferred_name": "CD22+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": 80.96785908349635, "identifiers": [{"i": "CL:1000618", "l": "juxtaglomerular complex cell", "d": ["Any kidney cortical cell that is part of some juxtaglomerular apparatus."], "t": []}], "preferred_name": "juxtaglomerular complex cell", "taxa": []}
{"type": "biolink:Cell", "ic": 69.61095963409787, "identifiers": [{"i": "CL:0000775", "l": "neutrophil", "d": ["Any of the immature or mature forms of a granular leukocyte that in its mature form has a nucleus with three to five lobes connected by slender threads of chromatin, and cytoplasm containing fine inconspicuous granules and stainable by neutral dyes."], "t": []}], "preferred_name": "neutrophil", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:1000447", "l": "epithelial cell of stratum germinativum of esophagus", "d": ["A basal cell that is part of the epithelium of esophagus."], "t": []}, {"i": "UMLS:C1182708", "l": "Epithelial cell of stratum germinativum of esophagus", "d": [], "t": []}], "preferred_name": "epithelial cell of stratum germinativum of esophagus", "taxa": []}
{"type": "biolink:Cell", "ic": 76.22330125402472, "identifiers": [{"i": "CL:0000069", "l": "branched duct epithelial cell", "d": [], "t": []}], "preferred_name": "branched duct epithelial cell", "taxa": []}
{"type": "biolink:Cell", "ic": 92.76600187037766, "identifiers": [{"i": "UMLS:C0949666", "l": "Oxyphil Cells", "d": [], "t": []}, {"i": "NCIT:C12654", "l": "Oxyphil Cell", "d": ["A glandular cell with acidophilic cytoplasm that contains tightly packed mitochondria. Oxyphil cells are found in the thyroid gland (Hurthle cells) and parathyroid gland."], "t": []}, {"i": "MESH:D024862", "l": "Oxyphil Cells", "d": [], "t": []}], "preferred_name": "Oxyphil Cells", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1267984", "l": "Lymphocyte positive for CD97 antigen", "d": [], "t": []}, {"i": "SNOMEDCT:117424006", "l": "", "d": [], "t": []}], "preferred_name": "Lymphocyte positive for CD97 antigen", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "UMLS:C3146292", "l": "Mouse Basophil", "d": [], "t": []}, {"i": "NCIT:C22591", "l": "Mouse Basophil", "d": [], "t": []}], "preferred_name": "Mouse Basophil", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:1000342", "l": "enterocyte of epithelium proper of ileum", "d": ["An enterocyte that is part of the epithelium proper of ileum."], "t": []}, {"i": "UMLS:C2329553", "l": "Enterocyte of epithelium proper of ileum", "d": [], "t": []}], "preferred_name": "enterocyte of epithelium proper of ileum", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5157486", "l": "CD33 cells | Blood | Cell markers", "d": [], "t": []}], "preferred_name": "CD33 cells | Blood | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C3494246", "l": "Sf21 Cells", "d": [], "t": []}], "preferred_name": "Sf21 Cells", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5175162", "l": "Nucleated erythrocytes | XXX | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Nucleated erythrocytes | XXX | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1267854", "l": "Lymphocyte positive for both CD8 antigen and CD25 antigen", "d": [], "t": []}, {"i": "SNOMEDCT:116735005", "l": "", "d": [], "t": []}], "preferred_name": "Lymphocyte positive for both CD8 antigen and CD25 antigen", "taxa": []}
{"type": "biolink:Cell", "ic": 61.278637547029746, "identifiers": [{"i": "CL:0000098", "l": "sensory epithelial cell", "d": ["A specialized epithelial cell involved in sensory perception. Restricted to special sense organs of the olfactory, gustatory, and vestibulocochlear receptor systems; contain sensory cells surrounded by supportive, non-receptive cells."], "t": []}], "preferred_name": "sensory epithelial cell", "taxa": []}
{"type": "biolink:Cell", "ic": 73.49439205968403, "identifiers": [{"i": "CL:0000017", "l": "spermatocyte", "d": ["A male germ cell that develops from spermatogonia. The euploid primary spermatocytes undergo meiosis and give rise to the haploid secondary spermatocytes which in turn give rise to spermatids."], "t": []}, {"i": "UMLS:C0037863", "l": "Spermatocytes", "d": [], "t": []}, {"i": "NCIT:C12605", "l": "Spermatocyte", "d": ["An immature male germ cell that is formed during the spermatocytogenesis phase of spermatogenesis. Spermatocytes are derived from spermatogonia and develop into spermatids."], "t": []}, {"i": "MESH:D013090", "l": "Spermatocytes", "d": [], "t": []}], "preferred_name": "spermatocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C4683836", "l": "IL13Ralpha2-specific Hinge-optimized 4-1BB-co-stimulatory CAR/Truncated CD19-expressing Autologous TN/MEM Cells", "d": [], "t": []}, {"i": "NCIT:C141460", "l": "IL13Ralpha2-specific Hinge-optimized 4-1BB-co-stimulatory CAR/Truncated CD19-expressing Autologous TN/MEM Cells", "d": ["A preparation of ex vivo expanded, genetically modified autologous naïve and memory T-cells (TN/MEM) transduced with a replication incompetent, self-inactivating (SIN) lentiviral vector expressing a hinge-optimized, chimeric antigen receptor (CAR) specific for interleukin-13 receptor alpha 2 (IL13Ra2), and containing the cluster of differentiation 137 (CD137; 4-1BB) co-stimulatory signaling domain fused to the signaling domain of the T-cell antigen receptor complex zeta chain (CD3-zeta), and a truncated form of human cluster of differentiation 19 (CD19t), with potential immunostimulating and antineoplastic activities. Upon intratumoral or intracavitary administration, IL13Ra2-specific hinge-optimized 4-1BB-co-stimulatory CAR/truncated CD19-expressing autologous TN/MEM cells are directed to, and induce selective toxicity and cytolysis in, IL13Ra2-expressing tumor cells. IL13Ra2, overexpressed by a variety of tumor cell types, is associated with increased proliferation, migration and invasiveness of tumor cells. The co-stimulatory signaling domain enhances both proliferation of T-cells and antitumor activity. Hinge optimization prevents the recognition and clearance of the CAR by endogenous Fc receptors (FcRs). CD19t is used as a surface marker to both track and quantify the modified T-cells in vivo."], "t": []}], "preferred_name": "IL13Ralpha2-specific Hinge-optimized 4-1BB-co-stimulatory CAR/Truncated CD19-expressing Autologous TN/MEM Cells", "taxa": []}
{"type": "biolink:Cell", "ic": 73.85694246010084, "identifiers": [{"i": "CL:0000121", "l": "Purkinje cell", "d": ["An inhibitory neuron and the sole output neuron of the cerebellar cortex, the Purkinje cell's soma is located between the granular and molecular layers of the cerebellum. It is one of the largest neural cells in the mammalian brain, ranging from 50 to 80 micrometres in diameter. Purkinje cells have planar, fan-shaped dendrites that branch extensively with little overlap. This cell type receives synaptic input from parallel fibres, which modulate high-frequency spike activity known as \"simple spikes,\" and climbing fibres, which modulate infrequent calcium spike activity known as \"complex spikes\". Purkinje cells are involved in motor coordination, particularly in correcting movements in progress."], "t": []}, {"i": "UMLS:C0034143", "l": "Purkinje Cells", "d": [], "t": []}, {"i": "NCIT:C12651", "l": "Purkinje Cell", "d": ["A large neuron that transmits signals from the cerebellar cortex and play a major role in controlling motor movement."], "t": []}, {"i": "MESH:D011689", "l": "Purkinje Cells", "d": [], "t": []}, {"i": "SNOMEDCT:83626009", "l": "", "d": [], "t": []}], "preferred_name": "Purkinje cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5554950", "l": "Autologous Anti-BCMA CAR T-cells spCART-269", "d": [], "t": []}, {"i": "NCIT:C178325", "l": "Autologous Anti-BCMA CAR T-cells spCART-269", "d": ["A preparation of autologous T-lymphocytes that have been genetically engineered to express a chimeric antigen receptor (CAR) targeting the human tumor-associated antigen (TAA) B-cell maturation antigen (BCMA; tumor necrosis factor receptor superfamily member 17; TNFRSF17; CD269), with potential immunostimulating and antineoplastic activities. Upon administration, the autologous anti-BCMA CAR T-cells spCART-269 recognize and induce selective toxicity against BCMA-expressing tumor cells. BCMA, a tumor-specific antigen and a receptor for both a proliferation-inducing ligand (APRIL) and B-cell activating factor (BAFF), is a member of the tumor necrosis factor receptor superfamily (TNFRSF) and plays a key role in plasma cell survival. BCMA is found on the surfaces of plasma cells and is overexpressed on malignant plasma cells."], "t": []}], "preferred_name": "Autologous Anti-BCMA CAR T-cells spCART-269", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "MESH:D000090002", "l": "Stromal Vascular Fraction", "d": [], "t": []}], "preferred_name": "Stromal Vascular Fraction", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5447470", "l": "iPSC-derived Allogeneic Anti-CD19 1XX-CAR T-cells FT819", "d": [], "t": []}, {"i": "NCIT:C176850", "l": "iPSC-derived Allogeneic Anti-CD19 1XX-CAR T-cells FT819", "d": ["A preparation of off-the-shelf (OTS) T-lymphocytes, generated from an induced pluripotent stem cell (iPSC) line, that have been genetically modified to express a CD19 1XX chimeric antigen receptor (CAR) that targets the tumor-associated antigen (TAA) CD19, linked to the co-stimulatory intracellular signaling domains of CD28 and the zeta chain of the TCR (T-cell receptor)/CD3 complex (CD3-zeta) (CD28zeta; CD28z), and inserted into the T-cell receptor alpha constant (TRAC) locus and edited for elimination of TCR expression, with potential immunostimulating and antineoplastic activities. Upon administration, the iPSC-derived allogeneic anti-CD19 1XX-CAR T-cells FT819 specifically recognize and bind to CD19-expressing tumor cells, resulting in specific T-cell-mediated tumor cell lysis. CD19 antigen is a B-cell specific cell surface antigen, which is expressed in all B-cell lineage malignancies and normal B-cells. The CD19 1XX CAR T-cells include a 1928zeta mutant, 1XX, which contains one instead of all three immunoreceptor tyrosine-based activation motifs (iTAMs). This may help prevent counterproductive T-cell differentiation and exhaustion, and may enhance the anti-tumor activity of the CAR T-cells. By nullifying the TCR, the possibility of graft versus host disease (GvHD) is eliminated."], "t": []}], "preferred_name": "iPSC-derived Allogeneic Anti-CD19 1XX-CAR T-cells FT819", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C3176885", "l": "Blasts.cytoplasmic CD13", "d": [], "t": []}], "preferred_name": "Blasts.cytoplasmic CD13", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5419454", "l": "Autologous CD34+-enriched HSPCs Transduced with VSV-G Encoding IFN-a2", "d": [], "t": []}], "preferred_name": "Autologous CD34+-enriched HSPCs Transduced with VSV-G Encoding IFN-a2", "taxa": []}
{"type": "biolink:Cell", "ic": 44.612330722134004, "identifiers": [{"i": "CL:0000988", "l": "hematopoietic cell", "d": ["A cell of a hematopoietic lineage."], "t": []}, {"i": "UMLS:C2323499", "l": "Hematopoietic cell", "d": [], "t": []}], "preferred_name": "hematopoietic cell", "taxa": []}
{"type": "biolink:Cell", "ic": 90.871710685482, "identifiers": [{"i": "UMLS:C1711215", "l": "Bone Marrow Stem Cell Committed to the Basophil Lineage", "d": [], "t": []}, {"i": "NCIT:C43227", "l": "Bone Marrow Stem Cell Committed to the Basophil Lineage", "d": ["A primitive, undifferentiated blood cell which can undergo division and will give rise to a cell in the basophil lineage."], "t": []}], "preferred_name": "Bone Marrow Stem Cell Committed to the Basophil Lineage", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1183176", "l": "Set of aminergic cells in reticular formation", "d": [], "t": []}], "preferred_name": "Set of aminergic cells in reticular formation", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C4289823", "l": "Central Memory T-Lymphocyte", "d": [], "t": []}, {"i": "NCIT:C126420", "l": "Central Memory T-Lymphocyte", "d": ["Long-lived antigen-specific T-lymphocytes, which express CD45RO, L-selectin and CCR7. Upon subsequent exposure to their target antigen, these cells rapidly proliferate and differentiate into effector cells."], "t": []}], "preferred_name": "Central Memory T-Lymphocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 92.76600187037766, "identifiers": [{"i": "CL:1001064", "l": "kidney artery smooth muscle cell", "d": [], "t": []}], "preferred_name": "kidney artery smooth muscle cell", "taxa": []}
{"type": "biolink:Cell", "ic": 90.871710685482, "identifiers": [{"i": "CL:0000440", "l": "melanocyte stimulating hormone secreting cell", "d": ["A cell of the intermediate pituitary that produces melanocyte stimulating hormone."], "t": []}], "preferred_name": "melanocyte stimulating hormone secreting cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:3000000", "l": "ciliated epithelial cell of esophagus", "d": ["A ciliated epithelial cell of the esophagus."], "t": []}], "preferred_name": "ciliated epithelial cell of esophagus", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5572255", "l": "Leukocyte clumps | Body fluid | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Leukocyte clumps | Body fluid | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0000676", "l": "cap cell", "d": [], "t": []}], "preferred_name": "cap cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1719174", "l": "CD19+CD27+IgD+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:1373158003", "l": "", "d": [], "t": []}], "preferred_name": "CD19+CD27+IgD+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5380994", "l": "Cells.CD8.HLA-B8 CMV specific.CMV antigen stimulated gamma interferon producing", "d": [], "t": []}], "preferred_name": "Cells.CD8.HLA-B8 CMV specific.CMV antigen stimulated gamma interferon producing", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0009104", "l": "B cell zone reticular cell", "d": ["A fibroblastic reticular cell found in the lymph node germinal center dark zone (B cell zone)."], "t": []}], "preferred_name": "B cell zone reticular cell", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "CL:1000708", "l": "ureter adventitial cell", "d": ["Any ureteral cell that is part of some adventitia of ureter."], "t": []}], "preferred_name": "ureter adventitial cell", "taxa": []}
{"type": "biolink:Cell", "ic": 89.40238429118027, "identifiers": [{"i": "UMLS:C1709201", "l": "Neoplastic Somatotroph Cell with Abundant Secretory Granules", "d": [], "t": []}, {"i": "NCIT:C45939", "l": "Neoplastic Somatotroph Cell with Abundant Secretory Granules", "d": [], "t": []}], "preferred_name": "Neoplastic Somatotroph Cell with Abundant Secretory Granules", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5908010", "l": "Autologous Anti-GPRC5D CAR T-cells BMS-986393", "d": [], "t": []}], "preferred_name": "Autologous Anti-GPRC5D CAR T-cells BMS-986393", "taxa": []}
{"type": "biolink:Cell", "ic": 80.96785908349635, "identifiers": [{"i": "CL:0011025", "l": "exhausted T cell", "d": ["An effector T cell that displays impaired effector functions (e.g., rapid production of effector cytokines, cytotoxicity) and has limited proliferative potential."], "t": []}], "preferred_name": "exhausted T cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5157310", "l": "CD14 cells | Blood | Cell markers", "d": [], "t": []}], "preferred_name": "CD14 cells | Blood | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "MESH:D016175", "l": "B-Lymphocyte Subsets", "d": [], "t": []}], "preferred_name": "B-Lymphocyte Subsets", "taxa": []}
{"type": "biolink:Cell", "ic": 88.20185721311867, "identifiers": [{"i": "CL:4023071", "l": "L5/6 cck GABAergic interneuron (Mmus)", "d": ["A GABAergic cortical interneuron that expresses cck. L5/6 cck cells have soma found mainly in L5 and L6 and have large axonal arborization."], "t": []}], "preferred_name": "L5/6 cck GABAergic interneuron (Mmus)", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C4055458", "l": "Anti-HLA-A2/NY-ESO-1 TCR-transduced Autologous T Lymphocytes", "d": [], "t": []}, {"i": "NCIT:C122679", "l": "Anti-HLA-A2/NY-ESO-1 TCR-transduced Autologous T Lymphocytes", "d": ["Autologous human peripheral blood T-lymphocytes transduced with a lentiviral or retroviral vector encoding a human leukocyte antigen A2 (HLA-A2) restricted anti-cancer-testis antigen 1 (NY-ESO-1) T-cell receptor (TCR) gene, with potential antineoplastic activity. Following leukapheresis, isolation of lymphocytes, expansion ex vivo, transduction, and re-introduction into the patient, the anti-HLA-A2/NY-ESO-1 TCR-transduced autologous T lymphocytes recognize and bind to NY-ESO-1/HLA-A2-positive tumor cells. This results in cytotoxic T-lymphocyte (CTL)-mediated elimination of NY-ESO-1-positive cancer cells. NY-ESO-1, a tumor-associated antigen (TAA), is found in normal testis and on the surface of various tumor cell types."], "t": []}], "preferred_name": "Anti-HLA-A2/NY-ESO-1 TCR-transduced Autologous T Lymphocytes", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5854670", "l": "Anti-CLL1/Anti-CD33 CAR-T Cells LCAR-AMDR", "d": [], "t": []}, {"i": "NCIT:C199306", "l": "Anti-CLL1/Anti-CD33 CAR-T Cells LCAR-AMDR", "d": ["A preparation of T-lymphocytes that have been genetically modified to express a chimeric antigen receptor (CAR) specific for the tumor-associated antigens (TAAs) C-type-lectin-like molecule-1 (CLL-1; CLL1; C-type lectin domain family 12 member A; CLEC12A) and CD33, with potential immunomodulating and antineoplastic activities. Upon administration, the anti-CLL1/anti-CD33 CAR-T cells LCAR-AMDR specifically and simultaneously target and bind to CD33- and CLL1-expressing tumor cells. This induces selective toxicity in CD33- and CLL1-expressing tumor cells. CD33 is expressed on normal non-pluripotent hematopoietic stem cells and is overexpressed on myeloid leukemia cells. CLL1, a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily, is overexpressed in leukemic stem cells (LSCs) and plays an important role in disease progression and relapse for myeloid malignancies."], "t": []}], "preferred_name": "Anti-CLL1/Anti-CD33 CAR-T Cells LCAR-AMDR", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C4684891", "l": "Anti-K-RAS G12V mTCR-transduced Autologous Peripheral Blood Lymphocytes", "d": [], "t": []}, {"i": "NCIT:C142888", "l": "Anti-K-RAS G12V mTCR-transduced Autologous Peripheral Blood Lymphocytes", "d": ["Autologous peripheral blood lymphocytes (PBLs) transduced with an HLA class I histocompatibility antigen A*11:01 (HLA-A1101)-restricted murine T-cell receptor (mTCR) that recognizes the glycine to valine point mutation at position 12 (G12V) variant of K-RAS, with potential antineoplastic activity. HLA-A1101 positive PBLs are harvested from a K-RAS G12V-expressing cancer patient and transfected with a retroviral vector that encodes anti-K-RAS G12V mTCR. The transduced PBLs are then expanded in culture. When reintroduced to the patient, these anti-K-RAS G12V mTCR-expressing PBLs target and bind to K-RAS G12V-overexpressing tumor cells, which results in both cytokine secretion and tumor cell lysis. K-RAS, a member of the RAS family of oncogenes, serves an important role in cell signaling, division and differentiation. Mutation of K-RAS may induce constitutive signal transduction leading to tumor cell growth, proliferation, invasion, and metastasis."], "t": []}], "preferred_name": "Anti-K-RAS G12V mTCR-transduced Autologous Peripheral Blood Lymphocytes", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1267892", "l": "Lymphocyte positive for CD22 antigen", "d": [], "t": []}, {"i": "SNOMEDCT:116819008", "l": "", "d": [], "t": []}], "preferred_name": "Lymphocyte positive for CD22 antigen", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C2736926", "l": "CD10+FMC7+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:1373093007", "l": "", "d": [], "t": []}], "preferred_name": "CD10+FMC7+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "CL:0000747", "l": "cyanophore", "d": ["A pigment cell derived from the neural crest. Contains blue pigment of unknown chemical composition in fibrous organelles termed cyanosomes. This gives a blue appearance."], "t": []}], "preferred_name": "cyanophore", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "UMLS:C1708112", "l": "Fusiform Melanocyte", "d": [], "t": []}, {"i": "NCIT:C54078", "l": "Fusiform Melanocyte", "d": [], "t": []}], "preferred_name": "Fusiform Melanocyte", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C6070744", "l": "Granulocytes | Vaginal | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Granulocytes | Vaginal | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5886245", "l": "Cells.chromosome region 1p32 deletion", "d": [], "t": []}], "preferred_name": "Cells.chromosome region 1p32 deletion", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0009100", "l": "hepatic portal fibroblast", "d": ["A fibroblast located in the portal triad. Hepatic portal fibroblast are a non-parenchymal cell population located adjacent to bile duct epithelia in liver and are distinct from stellate cells. They differentiate into fibrogenic myofibroblasts during chronic injury states producing high levels of collagen."], "t": []}], "preferred_name": "hepatic portal fibroblast", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1267802", "l": "CYIG+ lymphocyte", "d": [], "t": []}, {"i": "SNOMEDCT:117506006", "l": "", "d": [], "t": []}], "preferred_name": "CYIG+ lymphocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "CL:0000358", "l": "sphincter associated smooth muscle cell", "d": ["A smooth muscle cell that is part of a sphincter. A sphincter is a typically circular muscle that normally maintains constriction of a natural body passage or orifice and which relaxes as required by normal physiological functioning."], "t": []}], "preferred_name": "sphincter associated smooth muscle cell", "taxa": []}
{"type": "biolink:Cell", "ic": 84.83823963392128, "identifiers": [{"i": "UMLS:C1514000", "l": "Neoplastic Large Cell with Abundant Pale Cytoplasm", "d": [], "t": []}, {"i": "NCIT:C37163", "l": "Neoplastic Large Cell with Abundant Pale Cytoplasm", "d": [], "t": []}], "preferred_name": "Neoplastic Large Cell with Abundant Pale Cytoplasm", "taxa": []}
{"type": "biolink:Cell", "ic": 57.73719225543571, "identifiers": [{"i": "UMLS:C1711172", "l": "therapeutic autologous lymphocytes", "d": [], "t": []}, {"i": "NCIT:C28681", "l": "Therapeutic Autologous Lymphocytes", "d": ["A population of lymphocytes isolated from an individual, altered in vitro, and returned to the same individual for therapeutic purposes. (NCI04)"], "t": []}], "preferred_name": "therapeutic autologous lymphocytes", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C4055421", "l": "Autologous WT1-TCRc4 Gene-transduced CD8-positive Tcm/Tn Lymphocytes", "d": [], "t": []}, {"i": "NCIT:C121308", "l": "Autologous WT1-TCRc4 Gene-transduced CD8-positive Tcm/Tn Lymphocytes", "d": ["Autologous, human CD8 T-lymphocytes, comprised of both central memory T-cells (Tcm) and naïve T-cells (Tn), that are transduced, ex vivo, with a self-inactivating (SIN) lentiviral vector encoding a high-affinity T-cell receptor (TCRc4) specific for the human tumor antigen Wilms tumor 1 (WT1) epitope 126-134 (RMFPNAPYL), with potential antineoplastic activity. Upon isolation of peripheral blood lymphocytes (PBLs), transduction, expansion ex vivo, priming of the Tn subset, but not the Tcm subset, with interleukin-21 (IL-21) and reintroduction of equal amounts of Tcm and Tn cells into the patient, WT1-TCRc4 gene-transduced CD8-positive Tcm/Tn lymphocytes redirect T-lymphocytes to WT1-expressing tumor cells and specifically bind to and lyse those cells. This inhibits proliferation of WT1-expressing tumor cells. WT1 protein, a zinc finger DNA-binding transcriptional regulator, is overexpressed in most leukemias and various solid tumors, while expression in normal, healthy tissues is very limited; its expression is correlated with aggressiveness and poor prognosis."], "t": []}], "preferred_name": "Autologous WT1-TCRc4 Gene-transduced CD8-positive Tcm/Tn Lymphocytes", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C2334588", "l": "Pyramidal cell of cerebral cortex", "d": [], "t": []}], "preferred_name": "Pyramidal cell of cerebral cortex", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5171712", "l": "Lymphocytes.vacuolated | Blood | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Lymphocytes.vacuolated | Blood | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4322733", "l": "CD56+ NK cell", "d": [], "t": []}], "preferred_name": "CD56+ NK cell", "taxa": []}
{"type": "biolink:Cell", "ic": 62.991521422342, "identifiers": [{"i": "CL:0000225", "l": "anucleate cell", "d": ["A cell that lacks a nucleus."], "t": []}, {"i": "UMLS:C1180924", "l": "Non-nucleated cell", "d": [], "t": []}], "preferred_name": "anucleate cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5154480", "l": "Basophils | Pericardial fluid | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Basophils | Pericardial fluid | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0000662", "l": "neuroglioblast (sensu Nematoda)", "d": [], "t": []}], "preferred_name": "neuroglioblast (sensu Nematoda)", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5706377", "l": "Allogeneic NAM-expanded NK Cells GDA-201", "d": [], "t": []}], "preferred_name": "Allogeneic NAM-expanded NK Cells GDA-201", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "CL:0020010", "l": "arkypallidal neuron", "d": ["A GABAergic projection neuron located in the external segment of the globus pallidus (GPe) and defined by its exclusive projection to the dorsal striatum rather than to the subthalamic nucleus or basal ganglia output nuclei. In rodents and primates, it is characterized molecularly by expression of FOXP2, MEIS2, and NPAS1, and lacks expression of canonical pallidal markers NKX2-1 and LHX6 (Dodson et al., 2015; Abdi et al., 2015; Courtney et al., 2023). This neuron is GABAergic (GAD1/2⁺, SLC32A1/VGAT⁺) and typically PV⁻, forming the transcriptionally and developmentally LGE-derived subclass of GPe neurons (Dodson et al., 2015; Mallet et al., 2012)."], "t": []}], "preferred_name": "arkypallidal neuron", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1564017", "l": "Gastric delta Cells", "d": [], "t": []}], "preferred_name": "Gastric delta Cells", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5960911", "l": "Anti-mesothelin CAR T-cells UCMYM802", "d": [], "t": []}, {"i": "NCIT:C208072", "l": "Anti-mesothelin CAR T-cells UCMYM802", "d": ["A preparation of T-lymphocytes that have been genetically modified to express a chimeric antigen receptor (CAR) specific for the human tumor-associated antigen (TAA) mesothelin (MSLN), with potential immunomodulating and antineoplastic activities. Upon administration, anti-MSLN CAR T-cells UCMYM802 specifically target and kill MSLN-expressing tumor cells. MSLN, a cell surface glycoprotein involved in cell adhesion, is overexpressed in a variety of cancer cell types."], "t": []}], "preferred_name": "Anti-mesothelin CAR T-cells UCMYM802", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5157472", "l": "CD3+TCR alpha beta+ cells | Blood | Cell markers", "d": [], "t": []}], "preferred_name": "CD3+TCR alpha beta+ cells | Blood | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": 80.96785908349635, "identifiers": [{"i": "CL:0002504", "l": "enteric smooth muscle cell", "d": ["A smooth muscle cell of the intestine."], "t": []}], "preferred_name": "enteric smooth muscle cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1267931", "l": "Lymphocyte positive for CD45RB antigen", "d": [], "t": []}, {"i": "SNOMEDCT:117374009", "l": "", "d": [], "t": []}], "preferred_name": "Lymphocyte positive for CD45RB antigen", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4033156", "l": "jugular ganglion SPARCL1 neuron", "d": ["A sensory neuron that has the soma located in the jugular ganglion and expresses the marker SPARC-like protein 1 (SPARCL1)."], "t": []}], "preferred_name": "jugular ganglion SPARCL1 neuron", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C4086009", "l": "Autologous T-lymphocytes-expressing NY-ESO-1-C259-specific Enhanced T-cell Receptors", "d": [], "t": []}, {"i": "NCIT:C124655", "l": "Autologous T-lymphocytes-expressing NY-ESO-1-C259-specific Enhanced T-cell Receptors", "d": ["Human autologous lymphocytes transduced with a retroviral vector encoding a T-cell receptor (TCR) specific for the cancer/testis antigen NY-ESO-1, with potential antineoplastic activity. Upon isolation, transduction, expansion ex vivo, and reintroduction into the patient, the autologous T-lymphocytes expressing NY-ESO-1-C259-specific enhanced T-cell receptors bind to NY-ESO-1-overexpressing tumor cells. This may result in the specific cytotoxic T-lymphocyte (CTL) killing of NY-ESO-1-positive cancer cells. NY-ESO-1, a tumor-associated antigen (TAA), is found in normal testis and on the surface of various tumor cell types; the TCR is specific for SLLMWITQC, an NY-ESO-1-derived peptide, in a complex with human leukocyte antigen (HLA) A2 peptide."], "t": []}], "preferred_name": "Autologous T-lymphocytes-expressing NY-ESO-1-C259-specific Enhanced T-cell Receptors", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5184822", "l": "Variant lymphocytes | Peritoneal fluid | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Variant lymphocytes | Peritoneal fluid | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1979663", "l": "BCLXL+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:725314007", "l": "", "d": [], "t": []}], "preferred_name": "BCLXL+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0004228", "l": "broad diffuse amacrine cell", "d": ["An amacrine cell with a small dendritic field that has post-synaptic terminals in S1, S2, S3, and S4."], "t": []}], "preferred_name": "broad diffuse amacrine cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4240445", "l": "Vascular smooth muscle cell of aorta", "d": [], "t": []}], "preferred_name": "Vascular smooth muscle cell of aorta", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4510882", "l": "Blast cell positive for CD36 antigen", "d": [], "t": []}, {"i": "SNOMEDCT:725109000", "l": "", "d": [], "t": []}], "preferred_name": "Blast cell positive for CD36 antigen", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1441141", "l": "Immature reticulocyte", "d": [], "t": []}, {"i": "SNOMEDCT:409888001", "l": "", "d": [], "t": []}], "preferred_name": "Immature reticulocyte", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5853372", "l": "Lyophilized activated platelets", "d": [], "t": []}], "preferred_name": "Lyophilized activated platelets", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5417842", "l": "Autologous Bispecific CD19/CD22-targeted CAR-T Cells GC022", "d": [], "t": []}, {"i": "NCIT:C171093", "l": "Autologous Bispecific CD19/CD22-targeted CAR-T Cells GC022", "d": ["A preparation of autologous human T-lymphocytes engineered to express chimeric T-cell receptors (chimeric antigen receptors or CARs) targeting the tumor-associated antigens (TAAs) CD19 and CD22 and fused to as of yet not fully elucidated co-stimulatory domains, with potential immunostimulating and antineoplastic activities. Upon administration, the autologous bispecific CD19/CD22-targeted CAR-T cells GC022 bind to CD19 and CD22 on the surface of, and induce selective toxicity against, tumor cells expressing CD19 and CD22. CD19 and CD22, both transmembrane phosphoglycoproteins expressed on the surface of cells in the B lineage, are overexpressed on malignant B-cells."], "t": []}], "preferred_name": "Autologous Bispecific CD19/CD22-targeted CAR-T Cells GC022", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C4086006", "l": "Autologous Cytotoxic T-lymphocytes Induced with MUC1 Peptide-pulsed Dendritic Cells", "d": [], "t": []}, {"i": "NCIT:C124998", "l": "Autologous Cytotoxic T-lymphocytes Induced with MUC1 Peptide-pulsed Dendritic Cells", "d": ["A preparation of autologous cytotoxic T-lymphocytes (CTL), specifically reactive to the tumor-associated antigen (TAA) mucin-1 (MUC1), with potential antineoplastic activity. Peripheral blood mononuclear cells (PBMCs) are collected from the patient with MUC1-positive tumors and are exposed ex vivo to dendritic cells (DCs) that are pulsed with a MUC1 peptide to generate MUC1-specific CTLs, which are subsequently expanded in vitro. Upon re-infusion of autologous CTLs induced with MUC1 peptide-pulsed DCs to the patient, the CTLs target and lyse the MUC1-expressing tumor cells. This inhibits tumor cell proliferation. MUC1 is expressed by a variety of tumor cell types."], "t": []}], "preferred_name": "Autologous Cytotoxic T-lymphocytes Induced with MUC1 Peptide-pulsed Dendritic Cells", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0009099", "l": "fibro/adipogenic progenitor cell", "d": ["A progenitor cell that is a tissue-resident mesenchymal cell, important for skeletal muscle regeneration, and able to differentiate into both adipocytes or fibroblasts."], "t": []}], "preferred_name": "fibro/adipogenic progenitor cell", "taxa": []}
{"type": "biolink:Cell", "ic": 85.53200374075534, "identifiers": [{"i": "CL:1000893", "l": "kidney venous blood vessel cell", "d": ["Any kidney blood vessel cell that is part of some renal vein."], "t": []}], "preferred_name": "kidney venous blood vessel cell", "taxa": []}
{"type": "biolink:Cell", "ic": 68.10263212560105, "identifiers": [{"i": "UMLS:C1709176", "l": "Neoplastic Follicle Center B-Cell", "d": [], "t": []}, {"i": "NCIT:C45317", "l": "Neoplastic Follicle Center B-Cell", "d": [], "t": []}], "preferred_name": "Neoplastic Follicle Center B-Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 92.76600187037766, "identifiers": [{"i": "UMLS:C1514090", "l": "Neoplastic Small Mature Neuroepithelial Cell", "d": [], "t": []}, {"i": "NCIT:C41837", "l": "Neoplastic Small Mature Neuroepithelial Cell", "d": [], "t": []}], "preferred_name": "Neoplastic Small Mature Neuroepithelial Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0004137", "l": "retinal ganglion cell A2 inner", "d": ["A retinal ganglion A2 cell with dendrites terminating in S4."], "t": []}], "preferred_name": "retinal ganglion cell A2 inner", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C3899817", "l": "CD19CAR-CD3zeta-4-1BB-CD28-expressing Autologous T-Lymphocytes", "d": [], "t": []}, {"i": "NCIT:C116069", "l": "CD19CAR-CD3zeta-4-1BB-CD28-expressing Autologous T-Lymphocytes", "d": ["Autologous T-lymphocytes transduced with a retroviral vector expressing a chimeric antigen receptor (CAR) consisting of an anti-CD19 scFv (single chain variable fragment) coupled to three co-stimulatory signaling domains derived from CD28, 4-1BB (CD137), and the zeta chain of the T-cell receptor (TCR)/CD3 complex (CD3-zeta), with potential immunomodulating and antineoplastic activities. Upon transfusion, the CD19CAR-CD3zeta-4-1BB-CD28-expressing autologous T-lymphocytes direct the T-lymphocytes to CD19-expressing tumor cells and induce their selective toxicity. CD28, a T-cell surface-associated co-stimulatory molecule, is required for T-cell activation, proliferation, and survival. The 4-1BB co-stimulatory molecule signaling domain enhances activation and signaling after recognition of CD19. CD3-zeta is a transmembrane signaling adaptor polypeptide that regulates the assembly of TCR complexes, modulates the expression of the complex on the cell surface and plays a key role in antigen recognition. CD19 antigen, a B-cell specific cell surface antigen, is expressed in all B-cell lineage malignancies."], "t": []}], "preferred_name": "CD19CAR-CD3zeta-4-1BB-CD28-expressing Autologous T-Lymphocytes", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1267928", "l": "Lymphocyte positive for CD45 antigen", "d": [], "t": []}, {"i": "SNOMEDCT:116853007", "l": "", "d": [], "t": []}], "preferred_name": "Lymphocyte positive for CD45 antigen", "taxa": []}
{"type": "biolink:Cell", "ic": 74.11023018174025, "identifiers": [{"i": "CL:0000765", "l": "erythroblast", "d": ["A nucleated precursor of an erythrocyte that lacks hematopoietic lineage markers."], "t": []}, {"i": "UMLS:C2350151", "l": "Normoblasts", "d": [], "t": []}], "preferred_name": "erythroblast", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5382751", "l": "CD11a cells | Blood | Cell markers", "d": [], "t": []}], "preferred_name": "CD11a cells | Blood | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1518421", "l": "Mouse Olfactory Cell", "d": [], "t": []}, {"i": "NCIT:C22726", "l": "Mouse Olfactory Cell", "d": [], "t": []}], "preferred_name": "Mouse Olfactory Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5708216", "l": "Anti-CD38-CAR-TCRz/4-1BB-expressing T-lymphocytes", "d": [], "t": []}, {"i": "NCIT:C189049", "l": "Anti-CD38-CAR-TCRz/4-1BB-expressing T-lymphocytes", "d": ["A preparation of genetically modified T-lymphocytes that have been transduced with a lentiviral vector expressing a chimeric antigen receptor (CAR) specific for the tumor-associated antigen (TAA) cluster of differentiation 38 (CD38) that is linked to tandem costimulatory domains of the zeta chain of the T-cell receptor (TCR)/CD3 complex (CD3z) and 4-1BB (CD137), with potential immunostimulating and antineoplastic activities. Upon administration, anti-CD38-CAR-TCRz/4-1BB-expressing T-lymphocytes are directed to and induce selective toxicity in CD38-expressing tumor cells. CD38, a type II transmembrane glycoprotein, is present on various immune cells and hematologic malignancies, and its expression has been correlated with poor prognosis."], "t": []}], "preferred_name": "Anti-CD38-CAR-TCRz/4-1BB-expressing T-lymphocytes", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5216296", "l": "Neutrophils|NCnc|Pt|Synv fld", "d": [], "t": []}], "preferred_name": "Neutrophils|NCnc|Pt|Synv fld", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1267954", "l": "Lymphocyte positive for CD62L antigen", "d": [], "t": []}, {"i": "SNOMEDCT:117395004", "l": "", "d": [], "t": []}], "preferred_name": "Lymphocyte positive for CD62L antigen", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C0014355", "l": "Argentaffin Cell", "d": [], "t": []}, {"i": "NCIT:C12575", "l": "Enterochromaffin Cell", "d": ["The most abundant and widely distributed type of enteroendocrine cell found in the gastrointestinal tract. It is characterized by serotonin production and an affinity to binding silver and chromium salts."], "t": []}, {"i": "NCIT:C32140", "l": "Argentaffin Cell", "d": ["An enteroendocrine cell located in the basilar portions of the glands of the gastrointestinal tract. The granules in the cell stain readily with chromium and silver salts without pretreatment with a reducing agent."], "t": []}, {"i": "MESH:D004759", "l": "Enterochromaffin Cells", "d": [], "t": []}], "preferred_name": "Argentaffin Cell", "taxa": []}
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{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5171865", "l": "Macrophages | Cerebral spinal fluid | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Macrophages | Cerebral spinal fluid | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0229608", "l": "Histioblast", "d": [], "t": []}, {"i": "SNOMEDCT:1605008", "l": "", "d": [], "t": []}], "preferred_name": "Histioblast", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1511465", "l": "CY40", "d": [], "t": []}, {"i": "NCIT:C20239", "l": "CY40", "d": ["Provider: CyThera, Inc., San Diego, CA. No information from provider. This cell line meets the criteria for the use of human embryonic stem cells by federally funded researchers."], "t": []}], "preferred_name": "CY40", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5157383", "l": "CD20+FMC7+ cells | Body fluid | Cell markers", "d": [], "t": []}], "preferred_name": "CD20+FMC7+ cells | Body fluid | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5186846", "l": "Neutrophils | Fetus | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Neutrophils | Fetus | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C4085999", "l": "Autologous Anti-CD123 CAR TCR/4-1BB-expressing T-lymphocytes", "d": [], "t": []}, {"i": "NCIT:C125101", "l": "Autologous Anti-CD123 CAR TCR/4-1BB-expressing T-lymphocytes", "d": ["Autologous, genetically engineered T-lymphocytes that have been electroporated with a messenger RNA (mRNA) encoding a chimeric antigen receptor (CAR) consisting of an anti-human interleukin-3 receptor alpha chain (IL3RA; CD123) single chain variable fragment (scFv) coupled to the co-stimulatory signaling domains of 4-1BB (CD137) and the zeta chain of the T-cell receptor (TCR) CD3 complex (CD3-zeta), with potential immunomodulating and antineoplastic activities.  Upon transfusion, the mRNA-electroporated autologous anti-CD123 CAR TCR/4-1BB expressing T-lymphocytes attach to cancer cells expressing CD123. This induces selective toxicity in and causes lysis of CD123-expressing tumor cells. The 4-1BB co-stimulatory molecule signaling domain enhances T-cell activation and signaling after recognition of CD123. CD123 is normally expressed on committed blood progenitor cells in the bone marrow; its overexpression is associated with both increased leukemic cell proliferation and aggressiveness."], "t": []}], "preferred_name": "Autologous Anti-CD123 CAR TCR/4-1BB-expressing T-lymphocytes", "taxa": []}
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{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0000256", "l": "uric acid accumulating cell", "d": [], "t": []}], "preferred_name": "uric acid accumulating cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1522252", "l": "Mouse Ovarian Granulosa Cell", "d": [], "t": []}, {"i": "NCIT:C22662", "l": "Mouse Granulosa Cell", "d": [], "t": []}], "preferred_name": "Mouse Ovarian Granulosa Cell", "taxa": []}
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{"type": "biolink:Cell", "ic": 51.628955304037056, "identifiers": [{"i": "UMLS:C1513019", "l": "Mature B-Lymphocyte", "d": [], "t": []}, {"i": "NCIT:C33058", "l": "Mature B-Lymphocyte", "d": ["A descendant of a lymphoid stem cell that differentiates into either a plasma cell or a memory B cell in response to a specific antigen. The mature B lymphocyte develops and differentiates in the bone marrow."], "t": []}], "preferred_name": "Mature B-Lymphocyte", "taxa": []}
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{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1440146", "l": "Blasts.CD33", "d": [], "t": []}], "preferred_name": "Blasts.CD33", "taxa": []}
{"type": "biolink:Cell", "ic": 78.29800561113302, "identifiers": [{"i": "UMLS:C1514013", "l": "Neoplastic Mature Ganglion Cell", "d": [], "t": []}, {"i": "NCIT:C42084", "l": "Neoplastic Mature Ganglion Cell", "d": [], "t": []}], "preferred_name": "Neoplastic Mature Ganglion Cell", "taxa": []}
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{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0004225", "l": "spider amacrine cell", "d": ["A broadly stratifying amacrine cell with a small dendritic field, straight dendrites and post-synaptic terminals in S1, S2, and S3."], "t": []}], "preferred_name": "spider amacrine cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C2698062", "l": "Alpha-Galactosylceramide-Pulsed Autologous Dendritic Cells", "d": [], "t": []}, {"i": "NCIT:C78489", "l": "Alpha-Galactosylceramide-Pulsed Autologous Dendritic Cells", "d": ["A cancer vaccine comprised of autologous dendritic cells (DCs) pulsed with the marine sponge glycolipid alpha-galactosylceramide (alpha-GalCer) with potential immunostimulatory and antimetastatic activities. Upon administration, alpha-galactosylceramide-pulsed autologous dendritic cells may result in the activation and proliferation of a subset of endogenous natural killer T (NKT) cells, B cells, and CD4+ and CD8+ T cells, and the production of interferon-gamma and interleukin-12; these cascade events may result in a T helper-1 cell-biased proinflammatory antitumor immune response. The NKT cell ligand alpha-GalCer was originally isolated from the marine sponge Agelas mauritianusis."], "t": []}], "preferred_name": "Alpha-Galactosylceramide-Pulsed Autologous Dendritic Cells", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5419626", "l": "ROBO1-targeted BiCAR-NKT Cells", "d": [], "t": []}, {"i": "NCIT:C172380", "l": "ROBO1-targeted BiCAR-NKT Cells", "d": ["A preparation of natural killer T (NKT) cells engineered to express a chimeric antigen receptor (CAR) specific for roundabout homolog 1 (ROBO1, Robo1), with potential immunostimulating and antineoplastic activities. Upon administration, the ROBO1-targeted BiCAR-NK/T cells target and bind to ROBO1 expressed on the surface of tumor cells. This induces selective toxicity in ROBO1-expressing tumor cells. ROBO1, a member of the axon guidance receptor family, is often overexpressed in a variety of tumor types. It is involved in axon guidance, cell proliferation, cell motility and angiogenesis."], "t": []}], "preferred_name": "ROBO1-targeted BiCAR-NKT Cells", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5221012", "l": "Platelets.reticulated|NCnc|Pt|Bld", "d": [], "t": []}], "preferred_name": "Platelets.reticulated|NCnc|Pt|Bld", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4030055", "l": "intermediate cell of urothelium", "d": ["A urothelial cell that is part of the regenerative layer(s) of cells directly superficial to basal cells in urothelium. The layer of intermediate cells in the urothelium ranges from one to several layers thick depending on the species with intermediate cells attached to adjacent cell layers and one another via desmosomes."], "t": []}], "preferred_name": "intermediate cell of urothelium", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1440349", "l": "CD69+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:1372927006", "l": "", "d": [], "t": []}], "preferred_name": "CD69+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5155101", "l": "Bizarre platelets | Blood | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Bizarre platelets | Blood | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": 88.20185721311867, "identifiers": [{"i": "CL:1000280", "l": "smooth muscle cell of colon", "d": ["A smooth muscle cell that is part of the colon."], "t": []}, {"i": "UMLS:C0734782", "l": "Smooth muscle fiber of colon", "d": [], "t": []}], "preferred_name": "smooth muscle cell of colon", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1522235", "l": "Mouse Pancreas Acinar Cell", "d": [], "t": []}, {"i": "NCIT:C22643", "l": "Mouse Acinar Cell", "d": [], "t": []}], "preferred_name": "Mouse Pancreas Acinar Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 35.87795395804164, "identifiers": [{"i": "CL:0002321", "l": "embryonic cell (metazoa)", "d": ["A cell of the embryo."], "t": []}, {"i": "UMLS:C1947950", "l": "Embryonic Cell", "d": [], "t": []}, {"i": "NCIT:C13054", "l": "Embryonic Cell", "d": ["A cell formed in the initial stages of embryonic development, after zygote formation."], "t": []}], "preferred_name": "embryonic cell (metazoa)", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C2698130", "l": "Anti-CEA IgCD28TCR-Transduced Autologous T Cells", "d": [], "t": []}, {"i": "NCIT:C77865", "l": "Anti-CEA IgCD28TCR-Transduced Autologous T Cells", "d": ["A population of autologous tumor infiltrating lymphocytes (TIL) transduced with a retroviral vector encoding the chimeric gene IgCD28TCR with potential immunostimulating and antineoplastic activities. The chimeric IgCD28TCR gene consists of portions of CD28, the zeta chain of the T-cell receptor (TCRzeta), and a single chain antibody domain (sFv) specific for the tumor-associated antigen CEA.  Upon administration, these gene-modified TIL bind to tumor cells expressing CEA, which may result in activation and proliferation of TIL and an enhanced cytotoxic T-lymphocyte (CTL) response against CEA-expressing tumor cells. CEA may be overexpressed in various gastrointestinal and breast cancers. CD28, a T-cell surface-associated co-stimulatory molecule, is required for full T-cell activation, proliferation, and survival; expression of the CD28 fragment in this chimeric gene construct may impede activation-induced cell death (AICD) of TIL."], "t": []}], "preferred_name": "Anti-CEA IgCD28TCR-Transduced Autologous T Cells", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5446544", "l": "Autologous Universal CAR-expressing T-lymphocytes UniCAR02-T", "d": [], "t": []}, {"i": "NCIT:C175463", "l": "Autologous Universal CAR-expressing T-lymphocytes UniCAR02-T", "d": ["A preparation of autologous T-lymphocytes that has been genetically engineered to express a fully humanized, universal, second generation chimeric antigen receptor (CAR) with a CD28/CD3zeta co-stimulatory domain, and a binding domain that can recognize a peptide motive of an antigen-specific targeting module (TM), with potential immunomodulating and antineoplastic activities. Upon administration, autologous universal CAR-expressing T-lymphocytes UniCAR02-T remain inactivated. Upon administration of an antigen-specific TM, the binding domain of UniCAR02-T binds to the nuclear antigen motif of the TM, and UniCAR02-T is activated when the antigen-binding moiety of the TM binds to the specific antigen expressed on tumor cells. This induces selective toxicity in and causes lysis of tumor cells expressing the specific antigen."], "t": []}], "preferred_name": "Autologous Universal CAR-expressing T-lymphocytes UniCAR02-T", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:1000337", "l": "enterocyte of epithelium of duodenal gland", "d": ["An enterocyte that is part of the epithelium of duodenal gland."], "t": []}, {"i": "UMLS:C2334580", "l": "Enterocyte of epithelium of duodenal gland", "d": [], "t": []}], "preferred_name": "enterocyte of epithelium of duodenal gland", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1276977", "l": "Entire primordial sex cell", "d": [], "t": []}, {"i": "SNOMEDCT:343721007", "l": "", "d": [], "t": []}], "preferred_name": "Entire primordial sex cell", "taxa": []}
{"type": "biolink:Cell", "ic": 66.1054533964356, "identifiers": [{"i": "UMLS:C1514056", "l": "Neoplastic Perineural Cell", "d": [], "t": []}, {"i": "NCIT:C41413", "l": "Neoplastic Perineural Cell", "d": [], "t": []}], "preferred_name": "Neoplastic Perineural Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4072103", "l": "hair follicle dermal stem cell", "d": ["A bipotent mesenchymal stem cell that resides in the dermal sheath, specifically within the dermal sheath cup at the base of the hair follicle, characterized by its capacity for self-renewal and differentiation into both dermal sheath and dermal papilla cells throughout hair cycling. In humans, this cell is marked by enriched expression of gremlin-2 (GREM2) and dipeptidase-1 (DPEP1), and acts as a progenitor reservoir sustaining and regenerating the follicle's mesenchymal compartments."], "t": []}], "preferred_name": "hair follicle dermal stem cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4697031", "l": "Cells.CD38+IgM-", "d": [], "t": []}], "preferred_name": "Cells.CD38+IgM-", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1717630", "l": "Bizarre Cell", "d": [], "t": []}, {"i": "NCIT:C206319", "l": "Bizarre Cell", "d": ["A cell of squamous origin characterized by a dysmorphic, enlarged nucleus, an irregular nuclear membrane and hyperchromasia. It may be an associated finding in squamous intraepithelial lesions."], "t": []}], "preferred_name": "Bizarre Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 88.20185721311867, "identifiers": [{"i": "CL:0002622", "l": "prostate stromal cell", "d": ["A stromal cell of the prostate."], "t": []}], "preferred_name": "prostate stromal cell", "taxa": []}
{"type": "biolink:Cell", "ic": 56.78847871155304, "identifiers": [{"i": "UMLS:C1514100", "l": "Neoplastic Spindle Cell", "d": [], "t": []}, {"i": "NCIT:C36823", "l": "Neoplastic Spindle Cell", "d": [], "t": []}], "preferred_name": "Neoplastic Spindle Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5854379", "l": "Allogeneic Natural Killer Cells CHM 0201", "d": [], "t": []}, {"i": "NCIT:C198882", "l": "Allogeneic Natural Killer Cells CHM 0201", "d": ["A preparation of off-the-shelf (OTS) allogeneic, natural killer (NK) cells that are activated and expanded ex vivo, with potential cytolytic and antineoplastic activities. Upon administration, allogeneic NK cells CHM 0201 recognize and lyse cancer cells. These cells also secrete pro-inflammatory cytokines, which further stimulate an anti-tumor immune response."], "t": []}], "preferred_name": "Allogeneic Natural Killer Cells CHM 0201", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "CL:0002279", "l": "type L enteroendocrine cell", "d": ["A enteroendocrine cell type that is numerous in ileum, present in jejunum and large intestine, few in duodenum. This cell type produces glucagon-like immunoreactants (glicentin, glucagon-37, glucagon-29, GLP-1 and -2) and PYY."], "t": []}, {"i": "UMLS:C2333553", "l": "Type L enteroendocrine cell", "d": [], "t": []}], "preferred_name": "type L enteroendocrine cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1266875", "l": "Epidermal Langerhans cell", "d": [], "t": []}, {"i": "SNOMEDCT:127854005", "l": "", "d": [], "t": []}], "preferred_name": "Epidermal Langerhans cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5173432", "l": "Monocytes | Body fluid | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Monocytes | Body fluid | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5170918", "l": "Leukocytes | Blood cord | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Leukocytes | Blood cord | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5418112", "l": "Haploidentical Natural Killer Cells K-NK002", "d": [], "t": []}, {"i": "NCIT:C175232", "l": "Haploidentical Natural Killer Cells K-NK002", "d": ["A population of ex-vivo expanded and activated haploidentical donor-derived natural killer (NK) cells, with potential immunomodulating and antineoplastic activities. Upon administration prior to and following haploidentical hematopoietic cell transplantation, the haploidentical NK cells K-NK002 may induce an anti-tumor immune response and may exert cytotoxicity against tumor cells."], "t": []}], "preferred_name": "Haploidentical Natural Killer Cells K-NK002", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5557524", "l": "BCMA-specific Universal CAR-expressing T-lymphocytes LCAR-BCX", "d": [], "t": []}, {"i": "NCIT:C178575", "l": "BCMA-specific Universal CAR-expressing T-lymphocytes LCAR-BCX", "d": ["A preparation of universal T-lymphocytes that have been genetically modified to express a chimeric antigen receptor (CAR) targeting the tumor-associated antigen (TAA) B-cell maturation antigen (BCMA), with potential immunostimulating and antineoplastic activities. Upon intravenous administration, BCMA-specific universal CAR-expressing T-lymphocytes LCAR-BCX are directed to cells expressing BCMA and induce selective toxicity in BCMA-expressing tumor cells. BCMA, a receptor for both a proliferation-inducing ligand (APRIL) and B-cell activating factor (BAFF), is a member of the tumor necrosis factor receptor superfamily (TNFRSF) and plays a key role in plasma cell survival. BCMA is overexpressed on malignant plasma cells."], "t": []}], "preferred_name": "BCMA-specific Universal CAR-expressing T-lymphocytes LCAR-BCX", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5966208", "l": "KTEC19", "d": [], "t": []}], "preferred_name": "KTEC19", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1440348", "l": "CD68+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:1372926002", "l": "", "d": [], "t": []}], "preferred_name": "CD68+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4510904", "l": "Blast cell positive for CD179a antigen", "d": [], "t": []}, {"i": "SNOMEDCT:724249006", "l": "", "d": [], "t": []}], "preferred_name": "Blast cell positive for CD179a antigen", "taxa": []}
{"type": "biolink:Cell", "ic": 74.37365206292206, "identifiers": [{"i": "UMLS:C1514009", "l": "Neoplastic Leydig Cell", "d": [], "t": []}, {"i": "NCIT:C36896", "l": "Neoplastic Leydig Cell", "d": [], "t": []}], "preferred_name": "Neoplastic Leydig Cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5170945", "l": "Leukocytes | Vaginal | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Leukocytes | Vaginal | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": 56.09192508175291, "identifiers": [{"i": "UMLS:C1517806", "l": "Leukemic Cell", "d": [], "t": []}, {"i": "NCIT:C25553", "l": "Leukemic Cell", "d": ["Malignant hematopoietic cell originating in the clonal proliferation of myeloid or lymphoid precursor that undergoes an aberrant and poorly regulated process of organogenesis resulted in arrested maturation and cell capacity for unlimited self-renewal."], "t": []}], "preferred_name": "Leukemic Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:1000706", "l": "ureter urothelial cell", "d": ["A urothelial cell that is part of the urothelium of ureter."], "t": []}], "preferred_name": "ureter urothelial cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1956121", "l": "Skin Dendritic Cells", "d": [], "t": []}], "preferred_name": "Skin Dendritic Cells", "taxa": []}
{"type": "biolink:Cell", "ic": 78.80476858236055, "identifiers": [{"i": "CL:0000856", "l": "neuromast hair cell", "d": ["Neuromast hair cell is a hair cell that acts as a sensory receptor of the neuromast; it is morphologically polarized as a result of the relative position of the single kinocilium and the clusters of stereocilia on its apical surface."], "t": []}], "preferred_name": "neuromast hair cell", "taxa": []}
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{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1267981", "l": "Lymphocyte positive for CD94 antigen", "d": [], "t": []}, {"i": "SNOMEDCT:117421003", "l": "", "d": [], "t": []}], "preferred_name": "Lymphocyte positive for CD94 antigen", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5783500", "l": "Anti-CD19 Cord Blood-derived CAR-NK Cells", "d": [], "t": []}], "preferred_name": "Anti-CD19 Cord Blood-derived CAR-NK Cells", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4697020", "l": "Cell negative for CD25 antigen and positive for CD127 antigen", "d": [], "t": []}, {"i": "SNOMEDCT:1373171000", "l": "", "d": [], "t": []}], "preferred_name": "Cell negative for CD25 antigen and positive for CD127 antigen", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C2826134", "l": "HUMAN ALLOGENIC MYELOID PROGENITOR CELLS", "d": [], "t": []}], "preferred_name": "HUMAN ALLOGENIC MYELOID PROGENITOR CELLS", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C3274612", "l": "Allogeneic CD19-specific CAR-modified CD8 Plus Central Memory-derived Virus-specific T Cells", "d": [], "t": []}, {"i": "NCIT:C99215", "l": "Allogeneic CD19-specific CAR-modified CD8 Plus Central Memory-derived Virus-specific T Cells", "d": ["A preparation of allogeneic Epstein-Barr virus (EBV)- and human cytomegalovirus (CMV)-specific CD8+ central memory-derived T effector-lymphocytes that have been genetically modified to express a chimeric antigen receptor (CAR) anti-CD19/CD3 zeta chain fusion protein coupled to the intracellular signal domain of CD28 antigen, with potential immunostimulating, anti-viral and antineoplastic activities. Upon infusion, allogeneic CD19-specific CAR-modified CD8+ central memory-derived virus-specific T cells directs the T-lymphocytes to CD19-expressing tumor cells, stimulating a selective toxicity to tumor cells which may eventually result in tumor cell lysis. CD19 antigen is a B-cell specific cell surface antigen expressed in all B-cell lineage malignancies. The viral specific T-cells exert antiviral immunity."], "t": []}], "preferred_name": "Allogeneic CD19-specific CAR-modified CD8 Plus Central Memory-derived Virus-specific T Cells", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4740238", "l": "Spermatozoa.excess residual cytoplasm", "d": [], "t": []}], "preferred_name": "Spermatozoa.excess residual cytoplasm", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0002264", "l": "type A cell of stomach", "d": ["A type of enteroendocrine cell found in the stomach that secretes glucagon."], "t": []}, {"i": "UMLS:C2334654", "l": "Type A cell of stomach", "d": [], "t": []}], "preferred_name": "type A cell of stomach", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4040001", "l": "chorionic girdle cell", "d": ["A horse-specific, highly invasive trophoblast cell that invades the endometrium where it forms endometrial cups."], "t": []}], "preferred_name": "chorionic girdle cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4033082", "l": "cycling basal cell", "d": ["A(n) basal cell that is cycling."], "t": []}], "preferred_name": "cycling basal cell", "taxa": []}
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{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "CL:0002053", "l": "CD22-positive, CD38-low small pre-B cell", "d": ["A small pre-B cell that is CD22-positive and CD38-low."], "t": []}], "preferred_name": "CD22-positive, CD38-low small pre-B cell", "taxa": []}
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{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C3261871", "l": "Circulating tumor cells.prostate", "d": [], "t": []}], "preferred_name": "Circulating tumor cells.prostate", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4511888", "l": "Population of all atypical lymphocytes in portion of fluid", "d": [], "t": []}, {"i": "SNOMEDCT:726506006", "l": "", "d": [], "t": []}], "preferred_name": "Population of all atypical lymphocytes in portion of fluid", "taxa": []}
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{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4696657", "l": "CD3+CD4+CD28+HLA-DR+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:1373248008", "l": "", "d": [], "t": []}], "preferred_name": "CD3+CD4+CD28+HLA-DR+ cell", "taxa": []}
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{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0882903", "l": "Cell positive for CD56 antigen", "d": [], "t": []}, {"i": "SNOMEDCT:116828009", "l": "", "d": [], "t": []}], "preferred_name": "Cell positive for CD56 antigen", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "CL:0000600", "l": "heterokaryon", "d": ["A fungal cell with two or more genetically distinct nuclei."], "t": []}], "preferred_name": "heterokaryon", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1522253", "l": "Mouse Lutein Cell", "d": [], "t": []}, {"i": "NCIT:C22664", "l": "Mouse Lutein Cell", "d": [], "t": []}], "preferred_name": "Mouse Lutein Cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1440269", "l": "CD198+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:1372859000", "l": "", "d": [], "t": []}], "preferred_name": "CD198+ cell", "taxa": []}
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{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C6008048", "l": "Oocyte within ovarian follicle", "d": [], "t": []}, {"i": "SNOMEDCT:1351769001", "l": "", "d": [], "t": []}], "preferred_name": "Oocyte within ovarian follicle", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C4744827", "l": "Derived Cell Line", "d": [], "t": []}, {"i": "NCIT:C156445", "l": "Derived Cell Line", "d": ["A biospecimen generated by in vitro culturing of a single cell isolated from a tissue of interest."], "t": []}], "preferred_name": "Derived Cell Line", "taxa": []}
{"type": "biolink:Cell", "ic": 63.77603635410234, "identifiers": [{"i": "CL:0000147", "l": "pigment cell", "d": ["A pigment cell is a cell that contains pigment granules."], "t": []}, {"i": "UMLS:C0008572", "l": "Chromatophore", "d": [], "t": []}, {"i": "NCIT:C12581", "l": "Chromatophore", "d": ["A pigment-producing cell located in the deeper layers of the skin."], "t": []}, {"i": "MESH:D002856", "l": "Chromatophores", "d": [], "t": []}], "preferred_name": "pigment cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5170948", "l": "Leukocytes | XXX | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Leukocytes | XXX | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4023158", "l": "octopus cell of the mammalian cochlear nucleus", "d": ["A neuron in the posterior ventral cochlear nucleus that is distinguished by their long, thick and tentacle-shaped dendrites that typically emanate from one side of the cell body."], "t": []}], "preferred_name": "octopus cell of the mammalian cochlear nucleus", "taxa": []}
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{"type": "biolink:Cell", "ic": 70.44381585922123, "identifiers": [{"i": "CL:0000424", "l": "excretory cell", "d": ["A cell involved in the elimination of metabolic and foreign toxins, and in maintaining the ionic, acid-base and water balance of biological fluids."], "t": []}], "preferred_name": "excretory cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0002476", "l": "bone marrow macrophage", "d": ["A tissue-resident macrophage located in the bone marrow. This cell type is B220-negative, CD3e-negative, Ly-6C-negative, CD115-positive, F4/80-positive."], "t": []}], "preferred_name": "bone marrow macrophage", "taxa": []}
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{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5910061", "l": "Dazagamglogene Autogedtemcel", "d": [], "t": []}, {"i": "NCIT:C203029", "l": "Dazagamglogene Autogedtemcel", "d": [], "t": []}], "preferred_name": "Dazagamglogene Autogedtemcel", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1979677", "l": "CD81+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:1372935009", "l": "", "d": [], "t": []}], "preferred_name": "CD81+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": 90.871710685482, "identifiers": [{"i": "CL:0000407", "l": "scolopidial ligament cell", "d": ["A cell that anchors the cell body of a scolopidial neuron to the integument."], "t": []}], "preferred_name": "scolopidial ligament cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:1000359", "l": "microfold cell of epithelium proper of appendix", "d": ["A M cell that is part of the epithelium proper of appendix."], "t": []}, {"i": "UMLS:C2326918", "l": "Microfold cell of epithelium proper of appendix", "d": [], "t": []}], "preferred_name": "microfold cell of epithelium proper of appendix", "taxa": []}
{"type": "biolink:Cell", "ic": 69.74265740139907, "identifiers": [{"i": "CL:0000513", "l": "cardiac muscle myoblast", "d": ["A precursor cell destined to differentiate into cardiac muscle cell."], "t": []}], "preferred_name": "cardiac muscle myoblast", "taxa": []}
{"type": "biolink:Cell", "ic": 54.46878679519379, "identifiers": [{"i": "CL:0000145", "l": "professional antigen presenting cell", "d": ["A cell capable of processing and presenting lipid and protein antigens to T cells in order to initiate an immune response."], "t": []}, {"i": "UMLS:C0003315", "l": "Antigen-Presenting Cells", "d": [], "t": []}, {"i": "NCIT:C12621", "l": "Antigen Presenting Cell", "d": ["A cell that enables a T-lymphocyte to recognize an antigen by engulfing the antigen, breaking down the antigen into smaller fragments which bind to MHC molecules on the surface of the antigen presenting cell. The T-lymphocyte can now recognize and bind with the MHC-linked antigen."], "t": []}, {"i": "MESH:D000938", "l": "Antigen-Presenting Cells", "d": [], "t": []}], "preferred_name": "professional antigen presenting cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5163436", "l": "Eosinophils | Blood cord | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Eosinophils | Blood cord | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": 71.48355502057495, "identifiers": [{"i": "CL:1000612", "l": "kidney corpuscule cell", "d": ["Any renal cortical epithelial cell that is part of some renal corpuscle."], "t": []}], "preferred_name": "kidney corpuscule cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4033032", "l": "diffuse bipolar 6 cell", "d": ["An ON diffuse bipolar cell that has a large dendritic field and large axon terminals, which show little or no overlap. This cell predominantly connects to narrow thorny ganglion cells."], "t": []}], "preferred_name": "diffuse bipolar 6 cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4331902", "l": "Immuncell-LC", "d": [], "t": []}], "preferred_name": "Immuncell-LC", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5174641", "l": "Neutrophils.hypogranulated | Blood | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Neutrophils.hypogranulated | Blood | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4511515", "l": "Reticulocyte specimen", "d": [], "t": []}, {"i": "SNOMEDCT:725946000", "l": "", "d": [], "t": []}], "preferred_name": "Reticulocyte specimen", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4082861", "l": "Vascular smooth muscle cell", "d": [], "t": []}], "preferred_name": "Vascular smooth muscle cell", "taxa": []}
{"type": "biolink:Cell", "ic": 90.871710685482, "identifiers": [{"i": "UMLS:C1514016", "l": "Neoplastic Medium-Sized Myeloblast with Basophilic Agranular Cytoplasm", "d": [], "t": []}, {"i": "NCIT:C37177", "l": "Neoplastic Medium-Sized Myeloblast with Basophilic Agranular Cytoplasm", "d": [], "t": []}], "preferred_name": "Neoplastic Medium-Sized Myeloblast with Basophilic Agranular Cytoplasm", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1267863", "l": "Lymphocyte positive for both CD10 antigen and CD20 antigen", "d": [], "t": []}, {"i": "SNOMEDCT:117544002", "l": "", "d": [], "t": []}], "preferred_name": "Lymphocyte positive for both CD10 antigen and CD20 antigen", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C4764291", "l": "CRISPR-Cas9-mediated PD-1 and TCR Gene-deleted Anti-mesothelin CAR T-cells", "d": [], "t": []}, {"i": "NCIT:C158606", "l": "CRISPR-Cas9-mediated PD-1 and TCR Gene-deleted Anti-mesothelin CAR T-cells", "d": ["A preparation of human T-lymphocytes transduced with a chimeric antigen receptor (CAR) specific for the tumor-associated antigen (TAA) mesothelin and gene-edited with the clustered regularly interspaced short palindromic repeats (CRISPR)-Cas9 nuclease complex to eliminate endogenous TCR and programmed death 1 (PD-1; PDCD1; CD279; programmed cell death-1) expression, with potential immunostimulating and antineoplastic activities. The CRISPR guide RNA (gRNA) specifically targets and binds to complementary sites on TCRalpha, TCRbeta and PD-1. In turn, Cas9 cleaves these specific DNA sites, thereby disrupting transcription. Upon isolation, transduction, electroporation with TCRalpha, TCRbeta and PD-1 gRNAs, which are complexed to Cas9 RNA to disrupt expression of endogenous TCRalpha, TCRbeta and PD-1, expansion ex vivo, and introduction into the patient, the CRISPR-Cas9-mediated PD-1 and TCR gene-deleted anti-mesothelin CAR T-cells recognize and bind to mesothelin-overexpressing tumor cells. This may result in a specific cytotoxic T-lymphocyte (CTL)-mediated killing of mesothelin-positive tumor cells. PD-1, an immune checkpoint receptor expressed on T-cells, plays a key role in tumor immune evasion by binding to its ligand programmed death ligand 1 (PD-L1; cluster of differentiation 274; CD274; programmed cell death-1 ligand 1) expressed on tumor cells. By removing PD-1 from T-cells, PD-1-mediated signaling is halted which may decrease T-cell exhaustion and may enhance T-cell activity against the mesothelin-expressing tumor cells. Removal of endogenous TCR reduces TCR competition for expression, increases the persistence and function of the expressed transgenic TCR, enhances resistance to T-cell exhaustion and increases T-cell activity. Mesothelin is upregulated on a variety of tumor cell types."], "t": []}], "preferred_name": "CRISPR-Cas9-mediated PD-1 and TCR Gene-deleted Anti-mesothelin CAR T-cells", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5157525", "l": "CD3-CD56+ cells | Blood | Cell markers", "d": [], "t": []}], "preferred_name": "CD3-CD56+ cells | Blood | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0009044", "l": "lymphocyte of small intestine lamina propria", "d": ["A lymphocyte that resides in the lamina propria of the small intestine. Lamina propria leukocytes and intraepithelial lymphocytes are the effector compartments of the gut mucosal immune system. Lymphocytes circulate through gut associated lymphoid tissues until recruitment by intestinal antigens. They are involved in the gut immune response."], "t": []}], "preferred_name": "lymphocyte of small intestine lamina propria", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4243124", "l": "Set of erythropoietic cells", "d": [], "t": []}], "preferred_name": "Set of erythropoietic cells", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C0206436", "l": "Photoreceptor Cells, Invertebrate", "d": [], "t": []}, {"i": "NCIT:C12635", "l": "Photoreceptors, Invertebrate", "d": ["Specialized cells in invertebrate animals that convert light signals into nerve impulses."], "t": []}, {"i": "MESH:D017956", "l": "Photoreceptor Cells, Invertebrate", "d": [], "t": []}], "preferred_name": "Photoreceptor Cells, Invertebrate", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1148324", "l": "CD20+CD25+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:1372994006", "l": "", "d": [], "t": []}], "preferred_name": "CD20+CD25+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1636284", "l": "Cord blood stem cell", "d": [], "t": []}, {"i": "SNOMEDCT:419423006", "l": "", "d": [], "t": []}], "preferred_name": "Cord blood stem cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5907976", "l": "Allogeneic Natural Killer Cells IDP-023", "d": [], "t": []}, {"i": "NCIT:C202601", "l": "Allogeneic Natural Killer Cells IDP-023", "d": ["A preparation of off-the-shelf (OTS) allogeneic, natural killer (NK) cells that contains g minus NK cells (G-NKs), with potential cytolytic and antineoplastic activities. Upon administration, allogeneic NK cells IDP-023 recognize and lyse cancer cells. These cells also secrete pro-inflammatory cytokines, which further stimulate an anti-tumor immune response. G-NKs are deficient in the FceR1g protein and show increased cytokine secretion, higher levels of cytolytic enzymes, increased persistence, and higher antibody dependent cell mediated cytotoxicity (ADCC) when combined with monoclonal antibody treatment."], "t": []}], "preferred_name": "Allogeneic Natural Killer Cells IDP-023", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5983492", "l": "Nespecabtagene Autoleucel", "d": [], "t": []}, {"i": "NCIT:C211707", "l": "Nespecabtagene Autoleucel", "d": [], "t": []}], "preferred_name": "Nespecabtagene Autoleucel", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5854323", "l": "Hemacord", "d": [], "t": []}], "preferred_name": "Hemacord", "taxa": []}
{"type": "biolink:Cell", "ic": 81.34422831136257, "identifiers": [{"i": "CL:0002010", "l": "pre-conventional dendritic cell", "d": ["A lin-negative, MHC-II-negative, CD11c-positive, FLT3-positive cell with intermediate expression of SIRP-alpha."], "t": []}], "preferred_name": "pre-conventional dendritic cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0002616", "l": "perirenal adipocyte", "d": ["An adipocyte of perirenal fat tissue."], "t": []}], "preferred_name": "perirenal adipocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 84.21065366064373, "identifiers": [{"i": "CL:0000910", "l": "cytotoxic T cell", "d": ["A mature T cell that differentiated and acquired cytotoxic function with the phenotype perforin-positive and granzyme-B positive."], "t": []}], "preferred_name": "cytotoxic T cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4033166", "l": "myenteric ganglion of small intestine VIP/GAL neuron", "d": ["An enteric neuron that has the soma located in the myenteric ganglion of the small intestine and expresses the marker vasoactive intestinal peptide (VIP) and galanin (GAL)."], "t": []}], "preferred_name": "myenteric ganglion of small intestine VIP/GAL neuron", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1440149", "l": "Blasts.CD7", "d": [], "t": []}], "preferred_name": "Blasts.CD7", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1267798", "l": "CV+ lymphocyte", "d": [], "t": []}, {"i": "SNOMEDCT:117502008", "l": "", "d": [], "t": []}], "preferred_name": "CV+ lymphocyte", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5171862", "l": "Macrocytes | Blood | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Macrocytes | Blood | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4531900", "l": "Plasma cells.monotypic population", "d": [], "t": []}], "preferred_name": "Plasma cells.monotypic population", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C6050332", "l": "Autologous Anti-CD19 KIR-CAR-transduced T-cells SynKIR-310", "d": [], "t": []}, {"i": "NCIT:C216197", "l": "Autologous Anti-CD19 KIR-CAR-transduced T-cells SynKIR-310", "d": ["A preparation of autologous T-lymphocytes that have been genetically modified to express a killer cell immunoglobulin-like receptor (KIR)-based chimeric antigen receptor (CAR) consisting of an anti-CD19 single chain variable fragment (scFv) fused to the transmembrane and cytoplasmic domains of the stimulatory KIR 2DS2 (KIR2DS2), and the immunoreceptor tyrosine-based activation motif (ITAM)-containing adaptor protein and costimulatory chain DAP12, with potential immunomodulating and antineoplastic activities. Upon administration, the autologous anti-CD19 KIR-CAR-transduced T-cells SynKIR-310 specifically target and kill CD19-expressing tumor cells. CD19, a B-cell-specific cell surface antigen, is overexpressed in B-cell lineage malignancies and in certain B-cell-driven autoimmune diseases. KIR is normally expressed by natural killer (NK) cells, and KIR-based CAR may decrease T-cell exhaustion and enhance T-cell persistence."], "t": []}], "preferred_name": "Autologous Anti-CD19 KIR-CAR-transduced T-cells SynKIR-310", "taxa": []}
{"type": "biolink:Cell", "ic": 92.76600187037766, "identifiers": [{"i": "CL:0002590", "l": "smooth muscle cell of the brain vasculature", "d": ["A vascular associated smooth muscle cell of the brain vasculature."], "t": []}], "preferred_name": "smooth muscle cell of the brain vasculature", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5163441", "l": "Eosinophils | Nose | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Eosinophils | Nose | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": 57.054178630765854, "identifiers": [{"i": "UMLS:C4706671", "l": "Genetically modified T-cell", "d": [], "t": []}, {"i": "NCIT:C213868", "l": "Genetically-engineered T-cells", "d": ["Autologous or allogeneic T-cells that have been genetically modified."], "t": []}, {"i": "SNOMEDCT:764084004", "l": "", "d": [], "t": []}, {"i": "SNOMEDCT:764087006", "l": "", "d": [], "t": []}], "preferred_name": "Genetically modified T-cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C0029048", "l": "Oogonia", "d": [], "t": []}, {"i": "NCIT:C12600", "l": "Primary Oocyte", "d": ["An oocyte that is arrested in the diplotene stage of meiosis prophase 1."], "t": []}, {"i": "MESH:D009867", "l": "Oogonia", "d": [], "t": []}, {"i": "SNOMEDCT:78829006", "l": "", "d": [], "t": []}], "preferred_name": "Oogonia", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5417935", "l": "obecabtagene autoleucel", "d": [], "t": []}], "preferred_name": "obecabtagene autoleucel", "taxa": []}
{"type": "biolink:Cell", "ic": 75.38868324457971, "identifiers": [{"i": "UMLS:C1707339", "l": "Neoplastic Centrocyte", "d": [], "t": []}, {"i": "NCIT:C36743", "l": "Neoplastic Centrocyte", "d": [], "t": []}], "preferred_name": "Neoplastic Centrocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 66.26039393006171, "identifiers": [{"i": "UMLS:C1517532", "l": "Germinal Center B-Lymphocyte", "d": [], "t": []}, {"i": "NCIT:C38335", "l": "Germinal Center B-Lymphocyte", "d": ["A mature B-lymphocyte that is present in the geminal center of a lymphoid follicle."], "t": []}], "preferred_name": "Germinal Center B-Lymphocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "CL:0000781", "l": "mononuclear odontoclast", "d": ["A specialized mononuclear osteoclast associated with the absorption and removal of cementum."], "t": []}], "preferred_name": "mononuclear odontoclast", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C2951309", "l": "Endothelial cell of endocardium for left atrium", "d": [], "t": []}], "preferred_name": "Endothelial cell of endocardium for left atrium", "taxa": []}
{"type": "biolink:Cell", "ic": 55.83753240423128, "identifiers": [{"i": "CL:0008019", "l": "mesenchymal cell", "d": ["A non-polarised cell precursor cell that is part of some mesenchyme, is associated with the cell matrix but is not connected to other cells and is capable of migration."], "t": []}], "preferred_name": "mesenchymal cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5174613", "l": "Neutrophils | Blood cord | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Neutrophils | Blood cord | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C2736936", "l": "CD56-CD138+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:1373188007", "l": "", "d": [], "t": []}], "preferred_name": "CD56-CD138+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5420827", "l": "MUC-1/WT1 Peptide-primed Autologous Dendritic Cells", "d": [], "t": []}, {"i": "NCIT:C174519", "l": "MUC-1/WT1 Peptide-primed Autologous Dendritic Cells", "d": ["A cell-based cancer vaccine composed of autologous monocyte-derived dendritic cells (DCs) loaded with the human tumor-associated antigens (TAAs) mucin-1 (MUC1) and Wilms tumor protein 1 (WT1), with potential immunomodulating and antineoplastic activities. Upon vaccination, the MUC-1/WT1 peptide-primed autologous DCs expose the immune system to MUC1 and WT1 peptides and may stimulate the host immune system to mount a cytotoxic T-lymphocyte (CTL) response against MUC1 and WT1-expressing cancer cells, which could result in cancer cell lysis. MUC1 and WT1, are overexpressed in a variety of tumor types and play an important role in tumor cell proliferation."], "t": []}], "preferred_name": "MUC-1/WT1 Peptide-primed Autologous Dendritic Cells", "taxa": []}
{"type": "biolink:Cell", "ic": 92.76600187037766, "identifiers": [{"i": "CL:4301579", "l": "CBX MLI Megf11 Gaba_1 molecular layer interneuron (Mmus)", "d": ["A molecular layer interneuron of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Dnah11 (Mmus), Sla (Mmus), Gldc (Mmus), Sdk2 (Mmus). Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Supertype:1149 CBX MLI Megf11 Gaba_1."], "t": []}], "preferred_name": "CBX MLI Megf11 Gaba_1 molecular layer interneuron (Mmus)", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4322823", "l": "CD24+ B lymphocyte", "d": [], "t": []}], "preferred_name": "CD24+ B lymphocyte", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C6065164", "l": "AZD0120", "d": [], "t": []}], "preferred_name": "AZD0120", "taxa": []}
{"type": "biolink:Cell", "ic": 67.7493467736566, "identifiers": [{"i": "UMLS:C1518179", "l": "Malignant Epithelial Spindle Cell", "d": [], "t": []}, {"i": "NCIT:C37109", "l": "Malignant Epithelial Spindle Cell", "d": [], "t": []}], "preferred_name": "Malignant Epithelial Spindle Cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C2325885", "l": "Free macrophage", "d": [], "t": []}], "preferred_name": "Free macrophage", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4763339", "l": "Axonic neuron", "d": [], "t": []}], "preferred_name": "Axonic neuron", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:1001581", "l": "lateral ventricle glial cell", "d": ["Glial cell of lateral ventricle."], "t": []}], "preferred_name": "lateral ventricle glial cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5908979", "l": "Acmucabtagene Autoleucel", "d": [], "t": []}, {"i": "NCIT:C203090", "l": "Acmucabtagene Autoleucel", "d": [], "t": []}], "preferred_name": "Acmucabtagene Autoleucel", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0231010", "l": "Penetrated oocyte", "d": [], "t": []}, {"i": "SNOMEDCT:3447009", "l": "", "d": [], "t": []}], "preferred_name": "Penetrated oocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1879789", "l": "Basophilic Adenocarcinoma Cell", "d": [], "t": []}, {"i": "NCIT:C61051", "l": "Basophilic Adenocarcinoma Cell", "d": [], "t": []}], "preferred_name": "Basophilic Adenocarcinoma Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4033056", "l": "onychocyte", "d": ["A terminally differentiated, specialized keratinocyte originating primarily from the nail matrix. During onychokeratinization, these cells undergo progressive flattening and produce high levels of hard, disulfide cross-linked keratins (Eckhart et al., 2024) that form the rigid, compact nail plate. Unlike epidermal keratinocytes, onychocytes are firmly integrated into the nail plate and do not desquamate."], "t": []}], "preferred_name": "onychocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "CL:0000935", "l": "CD4-negative, CD8-negative, alpha-beta intraepithelial T cell", "d": ["A CD4-negative, CD8-negative, alpha-beta intraepithelial T cell that is found in the columnar epithelium of the gastrointestinal tract."], "t": []}], "preferred_name": "CD4-negative, CD8-negative, alpha-beta intraepithelial T cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4307089", "l": "OPC NN_1 Col27a1 oligodendrocyte precursor cell (Mmus)", "d": ["A oligodendrocyte precursor cell of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Pdgfra (Mmus), Olig1 (Mmus), Col27a1 (Mmus). It is distinguished from other OPC NN_1 cells by expression of Col27a1. These cells are located in the Midbrain, Pons, brain . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5269 OPC NN_1."], "t": []}], "preferred_name": "OPC NN_1 Col27a1 oligodendrocyte precursor cell (Mmus)", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4033124", "l": "lumbar ganglion TH neuron", "d": ["A sympathetic neuron that has the soma located in the lumbar ganglion and expresses the marker tyrosine hydroxylase (TH)."], "t": []}], "preferred_name": "lumbar ganglion TH neuron", "taxa": []}
{"type": "biolink:Cell", "ic": 92.76600187037766, "identifiers": [{"i": "CL:0002218", "l": "immature dendritic epithelial T cell precursor", "d": ["A double negative thymocyte that has a T cell receptor consisting of a gamma chain that has as part a Vgamma3 segment, and a delta chain. This cell type is CD4-negative, CD8-negative and CD24-positive. This cell-type is found in the fetal thymus with highest numbers occurring at E17-E18."], "t": []}], "preferred_name": "immature dendritic epithelial T cell precursor", "taxa": []}
{"type": "biolink:Cell", "ic": 80.96785908349635, "identifiers": [{"i": "CL:2000021", "l": "sebaceous gland cell", "d": ["Any native cell that is part of a sebaceous gland."], "t": []}], "preferred_name": "sebaceous gland cell", "taxa": []}
{"type": "biolink:Cell", "ic": 85.53200374075534, "identifiers": [{"i": "CL:1001320", "l": "urethra cell", "d": ["Any cell that is part of some urethra."], "t": []}], "preferred_name": "urethra cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C4764287", "l": "Autologous Cytotoxic T-lymphocytes Exposed to Dendritic Cells loaded with 6B11 Anti-idiotype Minibody", "d": [], "t": []}, {"i": "NCIT:C158601", "l": "Autologous Cytotoxic T-lymphocytes Exposed to Dendritic Cells loaded with 6B11 Anti-idiotype Minibody", "d": ["A preparation of autologous cytotoxic T-lymphocytes (CTLs) that are exposed, ex vivo, to autologous dendritic cells (DCs) loaded with the anti-idiotype minibody 6B11, which mimics the epithelial ovarian tumor-associated antigen (TAA), OC166-9, with potential immunostimulatory and antineoplastic activities. Upon administration, the CTLs exposed to DCs loaded with 6B11 anti-idiotype minibody target and kill autologous ovarian cells expressing the TAA."], "t": []}], "preferred_name": "Autologous Cytotoxic T-lymphocytes Exposed to Dendritic Cells loaded with 6B11 Anti-idiotype Minibody", "taxa": []}
{"type": "biolink:Cell", "ic": 71.48355502057495, "identifiers": [{"i": "CL:0000097", "l": "mast cell", "d": ["A cell that is found in almost all tissues containing numerous basophilic granules and capable of releasing large amounts of histamine and heparin upon activation. Progenitors leave bone marrow and mature in connective and mucosal tissue. Mature mast cells are found in all tissues, except the bloodstream. Their phenotype is CD117-high, CD123-negative, CD193-positive, CD200R3-positive, and FceRI-high. Stem-cell factor (KIT-ligand; SCF) is the main controlling signal of their survival and development."], "t": []}, {"i": "UMLS:C0024880", "l": "mast cell", "d": [], "t": []}, {"i": "NCIT:C12747", "l": "Mast Cell", "d": ["Mast cells are hematopoietic tissue cells that contain coarse, basophilic, metachromatic granules.  They are believed to contain heparin and histamine and derive from hematopoietic progenitor cells."], "t": []}, {"i": "MESH:D008407", "l": "Mast Cells", "d": [], "t": []}, {"i": "SNOMEDCT:6445007", "l": "", "d": [], "t": []}], "preferred_name": "mast cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0011000", "l": "dorsal horn interneuron", "d": ["A CNS interneuron located in the dorsal horn of the spinal cord."], "t": []}], "preferred_name": "dorsal horn interneuron", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5700404", "l": "Teb-cel", "d": [], "t": []}], "preferred_name": "Teb-cel", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "UMLS:C1513746", "l": "Multinucleated Malignant Squamous Cell", "d": [], "t": []}, {"i": "NCIT:C36774", "l": "Multinucleated Malignant Squamous Cell", "d": [], "t": []}], "preferred_name": "Multinucleated Malignant Squamous Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 92.76600187037766, "identifiers": [{"i": "CL:0000423", "l": "tip cell", "d": [], "t": []}], "preferred_name": "tip cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5421408", "l": "Allogeneic Red Cells Expressing 4-1BBL and IL-15TP", "d": [], "t": []}], "preferred_name": "Allogeneic Red Cells Expressing 4-1BBL and IL-15TP", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5171963", "l": "Malignant cells | Peritoneal fluid | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Malignant cells | Peritoneal fluid | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5216215", "l": "Erythrocytes|NCnc|Pt|Gast fld", "d": [], "t": []}], "preferred_name": "Erythrocytes|NCnc|Pt|Gast fld", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4322559", "l": "Set of antigen-presenting cells", "d": [], "t": []}], "preferred_name": "Set of antigen-presenting cells", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5216275", "l": "Monocytes|NCnc|Pt|Periton fld", "d": [], "t": []}], "preferred_name": "Monocytes|NCnc|Pt|Periton fld", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4023002", "l": "dynamic beta motor neuron", "d": ["A beta motor neuron that innervates the nuclear bag fibers of muscle spindles."], "t": []}], "preferred_name": "dynamic beta motor neuron", "taxa": []}
{"type": "biolink:Cell", "ic": 83.63771255585968, "identifiers": [{"i": "CL:0002334", "l": "preadipocyte", "d": ["An undifferentiated fibroblast that can be stimulated to form a fat cell."], "t": []}], "preferred_name": "preadipocyte", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1440357", "l": "CD7-CD13+CD33+cell", "d": [], "t": []}, {"i": "SNOMEDCT:1373279007", "l": "", "d": [], "t": []}], "preferred_name": "CD7-CD13+CD33+cell", "taxa": []}
{"type": "biolink:Cell", "ic": 80.61184433509295, "identifiers": [{"i": "CL:0002312", "l": "somatotroph", "d": ["An acidophilic cell of the anterior pituitary that produces growth hormone, somatotropin."], "t": []}, {"i": "UMLS:C1519424", "l": "Somatotrophs", "d": [], "t": []}, {"i": "NCIT:C33578", "l": "Somatotroph Cell", "d": ["An acidophil of the adenohypophysis that stains preferentially with orange G and secretes growth hormone."], "t": []}, {"i": "MESH:D052683", "l": "Somatotrophs", "d": [], "t": []}], "preferred_name": "somatotroph", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0000592", "l": "large luteal cell", "d": ["A large, progesterone secreting cell in the corpus luteum that develops from the granulosa cells."], "t": []}], "preferred_name": "large luteal cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0945923", "l": "Cells.CD21", "d": [], "t": []}], "preferred_name": "Cells.CD21", "taxa": []}
{"type": "biolink:Cell", "ic": 90.871710685482, "identifiers": [{"i": "CL:0000490", "l": "photopic photoreceptor cell", "d": [], "t": []}], "preferred_name": "photopic photoreceptor cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C4764288", "l": "Anti-EGFR CAR-transduced IL-12-expressing T-lymphocytes", "d": [], "t": []}, {"i": "NCIT:C158602", "l": "Anti-EGFR CAR-transduced IL-12-expressing T-lymphocytes", "d": ["A preparation of human T-lymphocytes transduced with a retroviral vector encoding an anti-epidermal growth factor receptor (EGFR) chimeric antigen receptor (CAR) gene coupled to the signaling domains from CD28, 4-1BB (CD137) and CD3 zeta, and modified to express the cytokine interleukin-12 (IL-12), with potential immunostimulatory and antineoplastic activities. Upon administration, the anti-EGFR CAR-transduced IL-12-expressing T-lymphocytes target and bind to the EGFR antigen on tumor cell surfaces; subsequently, EGFR-expressing tumor cells may be lysed. IL-12 expression activates the immune system by promoting the secretion of interferon-gamma (IFNg), activating natural killer cells (NKs), and inducing cytotoxic T-cell responses, which may result in both decreased cell proliferation and increased cell death for the EGFR-overexpressing tumor cells. EGFR, overexpressed by a variety of cancer cell types, plays a key role in tumor cell proliferation, tumor angiogenesis and radio- and chemoresistance."], "t": []}], "preferred_name": "Anti-EGFR CAR-transduced IL-12-expressing T-lymphocytes", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C2322965", "l": "Set of all cells", "d": [], "t": []}], "preferred_name": "Set of all cells", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C4727554", "l": "Autologous Anti-HER2-CAR-4-1BB-CD3zeta-CD19t+-expressing Tcm-enriched T-lymphocytes", "d": [], "t": []}, {"i": "NCIT:C154281", "l": "Autologous Anti-HER2-CAR-4-1BB-CD3zeta-CD19t+-expressing Tcm-enriched T-lymphocytes", "d": ["A preparation of genetically modified autologous central memory (Tcm) enriched T-cells transduced with a lentiviral vector expressing a chimeric antigen receptor (CAR) consisting of an anti-human epidermal growth factor receptor 2 (HER2) single chain variable fragment (scFv) derived from trastuzumab, with a 4-1BB (CD137) costimulatory domain that is linked to the signaling domain of the T-cell antigen receptor complex zeta chain (CD3-zeta) (BBz), and truncated CD19 (CD19t), with potential immunostimulatory and antineoplastic activities. Upon intravenous infusion, Anti-HER2-CAR-4-1BB-CD19t+-expressing Tcm-enriched T-lymphocytes are directed against HER2-expressing cells, thereby inducing selective toxicity in HER2-expressing tumor cells. HER2, a receptor tyrosine kinase, is mutated or overexpressed in many tumor cell types, plays a significant role in tumor cell proliferation and tumor vascularization. The BBz costimulatory signaling domain enhances proliferation of T-cells and antitumor activity, while CD19t, a marker for transduction, is utilized to calculate CAR T-cell dosing and for CAR-expressing cell tracking. Tcm cells have the capacity for long-lived persistence and retain their ability to proliferate upon antigen re-encounter. The immunoglobulin G4 (IgG4) extracellular spacer contains a double mutation, (L235E;N297Q) (EQ) within the CH2 region to reduce Fc receptor recognition."], "t": []}], "preferred_name": "Autologous Anti-HER2-CAR-4-1BB-CD3zeta-CD19t+-expressing Tcm-enriched T-lymphocytes", "taxa": []}
{"type": "biolink:Cell", "ic": 63.56446252712605, "identifiers": [{"i": "UMLS:C1514302", "l": "Precursor Natural Killer Cell", "d": [], "t": []}, {"i": "NCIT:C39300", "l": "Precursor Natural Killer Cell", "d": [], "t": []}], "preferred_name": "Precursor Natural Killer Cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1440311", "l": "CD42d+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:1372889007", "l": "", "d": [], "t": []}], "preferred_name": "CD42d+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C3831169", "l": "CD19CAR-CD28zeta-4-1BB-expressing Allogeneic T Lymphocytes", "d": [], "t": []}, {"i": "NCIT:C107242", "l": "CD19CAR-CD28zeta-4-1BB-expressing Allogeneic T Lymphocytes", "d": ["Allogeneic T-lymphocytes transduced with a retroviral vector expressing a chimeric antigen receptor (CAR) consisting of an anti-CD19 scFv (single chain variable fragment) coupled to the costimulatory signaling domain CD28, the signaling domain of 4-1BB (CD137), and the zeta chain of the T-cell receptor (TCR), with potential immunomodulating and antineoplastic activities. Upon transfusion, CD19CAR-CD28 zeta-4-1BB-expressing allogeneic T lymphocytes directs the T-lymphocytes to and induces selective toxicity in CD19-expressing tumor cells. CD28, a T-cell surface-associated co-stimulatory molecule, is required for T-cell activation, proliferation, and survival. The 4-1BB co-stimulatory molecule signaling domain enhances activation and signaling after recognition of CD19. Furthermore, inclusion of the 4-1BB signaling domain may increase the antitumor activity compared to the inclusion of the CD28 costimulatory domain and TCR zeta chain alone. CD19 antigen is a B-cell specific cell surface antigen, which is expressed in all B-cell lineage malignancies."], "t": []}], "preferred_name": "CD19CAR-CD28zeta-4-1BB-expressing Allogeneic T Lymphocytes", "taxa": []}
{"type": "biolink:Cell", "ic": 69.94527858408269, "identifiers": [{"i": "CL:0002425", "l": "early T lineage precursor", "d": ["A pro-T cell that is lin-negative, CD25-negative, CD127-negative, CD44-positive and kit-positive."], "t": []}], "preferred_name": "early T lineage precursor", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5216261", "l": "Malignant cells|NCnc|Pt|Pericard fld", "d": [], "t": []}], "preferred_name": "Malignant cells|NCnc|Pt|Pericard fld", "taxa": []}
{"type": "biolink:Cell", "ic": 77.17927671370501, "identifiers": [{"i": "UMLS:C1709675", "l": "Primitive Skeletal Muscle Cell", "d": [], "t": []}, {"i": "NCIT:C49200", "l": "Primitive Skeletal Muscle Cell", "d": [], "t": []}], "preferred_name": "Primitive Skeletal Muscle Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 75.38868324457971, "identifiers": [{"i": "UMLS:C1709168", "l": "Neoplastic Chromaffin Cell", "d": [], "t": []}, {"i": "NCIT:C48559", "l": "Neoplastic Chromaffin Cell", "d": [], "t": []}], "preferred_name": "Neoplastic Chromaffin Cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C2825117", "l": "AlloStim", "d": [], "t": []}], "preferred_name": "AlloStim", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5783503", "l": "Autologous Anti-PSMA CAR/CD2/dnTGF-BRII/PD-1:CD28 Switch Receptor-expressing T-cells TmPSMA-02", "d": [], "t": []}, {"i": "NCIT:C190115", "l": "Autologous Anti-PSMA CAR/CD2/dnTGF-BRII/PD-1:CD28 Switch Receptor-expressing T-cells TmPSMA-02", "d": ["A preparation of autologous T-lymphocytes that have been genetically modified and transduced with a lentiviral vector to express a chimeric antigen receptor (CAR) consisting of an anti-prostate specific membrane antigen (PSMA) single chain variable fragment (scFv) and the co-stimulatory domain CD2, a dominant negative (dn) form of transforming growth factor-beta (TGF-beta; TGFb) receptor (dnTGF-BRII), and a PD-1:CD28 switch receptor composed of the extracellular ligand binding domain of the human inhibitory receptor programmed cell death protein 1 (PD-1; PDCD1) fused to the transmembrane and cytoplasmic co-stimulatory signaling domains of CD28, with potential immunomodulating and antineoplastic activities. Upon reintroduction into the patient, autologous anti-PSMA CAR/CD2/dnTGF-BRII/PD-1:CD28 switch receptor-expressing T-cells TmPSMA-02 are directed to and induce selective toxicity in PSMA-expressing tumor cells. PSMA, a tumor-associated antigen (TAA) and type II transmembrane protein, is expressed on the membrane of prostatic epithelial cells and overexpressed on prostate tumor cells as well as a variety of other solid tumors. The inclusion of dnTGF-BRII blocks the signaling of the immunosuppressive cytokine TGFb in the tumor microenvironment (TME) and makes the TmPSMA-02 T-cells resistant to TGFb. TGFb negatively regulates T-cell proliferation and activation and plays a key role in tumor immune suppression. The PD-1:CD28 switch receptor expressed by the TmPSMA-02 T-cells targets and binds to the PD-1 ligands, programmed cell death ligand 1 (PD-L1) and 2 (PD-L2), expressed on tumor cells. The nature of the PD-1/CD28 switch receptor fusion protein prevents the normal PD1/PD-L1-mediated T-cell suppression and, instead, promotes signaling through the CD28 domain, which results in the stimulation of T-lymphocytes. This induces enhanced toxicity against tumor cells."], "t": []}], "preferred_name": "Autologous Anti-PSMA CAR/CD2/dnTGF-BRII/PD-1:CD28 Switch Receptor-expressing T-cells TmPSMA-02", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5170903", "l": "Leukocyte clumps | Urine | Urinalysis", "d": [], "t": []}], "preferred_name": "Leukocyte clumps | Urine | Urinalysis", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5446460", "l": "Donor-Derived Multi-Tumor-Associated Antigen-specific T Cells", "d": [], "t": []}], "preferred_name": "Donor-Derived Multi-Tumor-Associated Antigen-specific T Cells", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C3898995", "l": "HLA-DP0401/0402-Restricted MAGE-A3-Reactive T Cell Receptor-transduced Autologous T Cells", "d": [], "t": []}, {"i": "NCIT:C115979", "l": "HLA-DP0401/0402-Restricted MAGE-A3-Reactive T Cell Receptor-transduced Autologous T Cells", "d": ["Human autologous T-lymphocytes transduced with a retroviral vector encoding a T-cell receptor (TCR) specific for the human leukocyte antigen (HLA)-DP0401/0402-restricted, melanoma antigen A3 (MAGE-A3), with potential antineoplastic activity. CD4-positive cells are isolated from a patient, transduced with an anti-MAGE-A3-DP0401/0402 restricted TCR, expanded ex vivo, and reintroduced into the HLA-DP0401/0402 positive patient. Then, the HLA-DP0401/0402-restricted, MAGE-A3-reactive TCR-transduced autologous T cells bind to tumor cells expressing the MAGE-A3 antigen, which may result in both an inhibition of growth and increased cell death for MAGE-A3-expressing cancer cells. The tumor-associated antigen MAGE-A3 is overexpressed by a variety of cancer cell types."], "t": []}], "preferred_name": "HLA-DP0401/0402-Restricted MAGE-A3-Reactive T Cell Receptor-transduced Autologous T Cells", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C3897804", "l": "RNA Electroporated CD19CAR-CD3zeta-4-1BB-expressing Autologous T-lymphocytes", "d": [], "t": []}, {"i": "NCIT:C118947", "l": "RNA Electroporated CD19CAR-CD3zeta-4-1BB-expressing Autologous T-lymphocytes", "d": ["Autologous, genetically engineered T-lymphocytes that have been electroporated with an mRNA encoding for an anti-CD19 chimeric antigen receptor (CAR) consisting of an anti-CD19 single chain variable fragment (scFv) coupled to the co-stimulatory signaling domain of 4-1BB (CD137) and the zeta chain of the T-cell receptor CD3 complex (CD3-zeta), with potential immunomodulating and antineoplastic activities.  Upon transfusion, the RNA electroporated CD19CAR-CD3zeta-4-1BB-expressing autologous T-lymphocytes attach to cancer cells expressing CD19. This induces selective toxicity against CD19-expressing tumor cells and causes tumor cell lysis. The 4-1BB co-stimulatory molecule signaling domain enhances T-cell activation and signaling after recognition of CD19. CD19 antigen is a B-cell specific cell surface antigen, which is expressed in all B-cell lineage malignancies."], "t": []}], "preferred_name": "RNA Electroporated CD19CAR-CD3zeta-4-1BB-expressing Autologous T-lymphocytes", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0228076", "l": "Primitive neuroblastic cell", "d": [], "t": []}, {"i": "SNOMEDCT:20367003", "l": "", "d": [], "t": []}], "preferred_name": "Primitive neuroblastic cell", "taxa": []}
{"type": "biolink:Cell", "ic": 62.48652591022127, "identifiers": [{"i": "CL:4023040", "l": "L2/3-6 intratelencephalic projecting glutamatergic neuron", "d": ["An intratelencephalic-projecting glutamatergic neuron with a soma found in cortical layers L2/3-6."], "t": []}], "preferred_name": "L2/3-6 intratelencephalic projecting glutamatergic neuron", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C2708698", "l": "HLA-B27+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:1373074005", "l": "", "d": [], "t": []}], "preferred_name": "HLA-B27+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": 79.9528279018387, "identifiers": [{"i": "UMLS:C1517107", "l": "Faggot Cell", "d": [], "t": []}, {"i": "NCIT:C37052", "l": "Faggot Cell", "d": [], "t": []}], "preferred_name": "Faggot Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0001079", "l": "NKp44-positive group 3 innate lymphoid cell, human", "d": ["A group 3 innate lymphoid cell in the human with the phenotype IL-7Ralpha-positive, and NKp44-positive."], "t": []}], "preferred_name": "NKp44-positive group 3 innate lymphoid cell, human", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4533461", "l": "Cells.CD4-CD8-CD45R+TCR alpha beta+", "d": [], "t": []}], "preferred_name": "Cells.CD4-CD8-CD45R+TCR alpha beta+", "taxa": []}
{"type": "biolink:Cell", "ic": 79.9528279018387, "identifiers": [{"i": "CL:0002043", "l": "CD34-positive, CD38-negative multipotent progenitor cell", "d": ["A hematopoietic multipotent progenitor cell that is CD34-positive, CD38-negative, CD45RA-negative, and CD90-negative."], "t": []}], "preferred_name": "CD34-positive, CD38-negative multipotent progenitor cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C2936239", "l": "HEK293 Cells", "d": [], "t": []}, {"i": "MESH:D057809", "l": "HEK293 Cells", "d": [], "t": []}], "preferred_name": "HEK293 Cells", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0000971", "l": "IgM memory B cell", "d": ["An IgM memory B cell is an unswitched memory B cell with the phenotype IgM-positive and IgD-negative."], "t": []}], "preferred_name": "IgM memory B cell", "taxa": []}
{"type": "biolink:Cell", "ic": 57.80196001233664, "identifiers": [{"i": "UMLS:C1518241", "l": "Malignant Small Cell", "d": [], "t": []}, {"i": "NCIT:C36860", "l": "Malignant Small Cell", "d": ["A malignant round or round to fusiform cell with scant amount of cytoplasm, small nucleus, and absent or inconspicuous nucleolus."], "t": []}], "preferred_name": "Malignant Small Cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1979645", "l": "Blasts.CD33+CD34+", "d": [], "t": []}], "preferred_name": "Blasts.CD33+CD34+", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5148822", "l": "Reticulocytes.high fluorescence", "d": [], "t": []}], "preferred_name": "Reticulocytes.high fluorescence", "taxa": []}
{"type": "biolink:Cell", "ic": 64.39556439996649, "identifiers": [{"i": "CL:0000235", "l": "macrophage", "d": ["A mononuclear phagocyte present in variety of tissues, typically differentiated from monocytes, capable of phagocytosing a variety of extracellular particulate material, including immune complexes, microorganisms, and dead cells."], "t": []}, {"i": "UMLS:C0024432", "l": "macrophage", "d": [], "t": []}, {"i": "NCIT:C12558", "l": "Macrophage", "d": ["A cell that arises from stem cells and/or bone marrow-derived monocytes that function in different aspects of host defense and tissue repair; such as phagocytosis, cytotoxic activity, and regulation of the immune response (antigen presentation and T-cell activation)."], "t": []}, {"i": "MESH:D008264", "l": "Macrophages", "d": [], "t": []}, {"i": "SNOMEDCT:58986001", "l": "", "d": [], "t": []}], "preferred_name": "macrophage", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5157669", "l": "CD8+CD38+ cells | Blood | Cell markers", "d": [], "t": []}], "preferred_name": "CD8+CD38+ cells | Blood | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0002147", "l": "clear chief cell of parathyroid gland", "d": ["A chief cell of parathyroid glands that does not stain with hematoxylin or eosin. This cell is larger, has a larger nucleus and fewer secretory granules than dark chief cells."], "t": []}, {"i": "UMLS:C1181299", "l": "Clear chief cell of parathyroid cell", "d": [], "t": []}, {"i": "NCIT:C33267", "l": "Parathyroid Gland Clear Cell", "d": ["A large cell of the parathyroid gland. It has abundant clear cytoplasm packed with glycogen and a basal nucleus."], "t": []}], "preferred_name": "clear chief cell of parathyroid gland", "taxa": []}
{"type": "biolink:Cell", "ic": 69.48184434309724, "identifiers": [{"i": "UMLS:C1519468", "l": "Neoplastic Spindle-Shaped Smooth Muscle Cell", "d": [], "t": []}, {"i": "NCIT:C36945", "l": "Neoplastic Spindle-Shaped Smooth Muscle Cell", "d": [], "t": []}], "preferred_name": "Neoplastic Spindle-Shaped Smooth Muscle Cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4740211", "l": "Erythrocytes.CD59 complete loss", "d": [], "t": []}], "preferred_name": "Erythrocytes.CD59 complete loss", "taxa": []}
{"type": "biolink:Cell", "ic": 85.53200374075534, "identifiers": [{"i": "UMLS:C4745256", "l": "Adenocarcinoma Cell with Abundant Pale Cytoplasm", "d": [], "t": []}, {"i": "NCIT:C54724", "l": "Adenocarcinoma Cell with Abundant Pale Cytoplasm", "d": [], "t": []}], "preferred_name": "Adenocarcinoma Cell with Abundant Pale Cytoplasm", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0011029", "l": "cnidocyte", "d": ["An explosive cell containing one giant secretory organelle called a cnidocyst (also known as a cnida (plural cnidae) or nematocyst) that contains a toxin responsible for the stings delivered by a cnidarian to other organisms. Cnidae are used to capture prey and as a defense against predators. The presence of cnidocytes defines the phylum Cnidaria (corals, sea anemones, hydrae, jellyfish, etc.)."], "t": []}], "preferred_name": "cnidocyte", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5418006", "l": "Mozafancogene autotemcel", "d": [], "t": []}], "preferred_name": "Mozafancogene autotemcel", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5216242", "l": "Lymphoblasts|NCnc|Pt|Bld", "d": [], "t": []}], "preferred_name": "Lymphoblasts|NCnc|Pt|Bld", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5157668", "l": "CD8+CD28+ cells | Blood | Cell markers", "d": [], "t": []}], "preferred_name": "CD8+CD28+ cells | Blood | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "CL:0000346", "l": "hair follicle dermal papilla cell", "d": ["A specialized fibroblast that resides in the dermal papilla located at the bottom of hair follicles. This cell orchestrates reciprocal epithelial-mesenchymal signaling essential for hair follicle morphogenesis and cycling, regulating matrix cell proliferation and differentiation to control hair shaft size, shape, and growth. The dermal papilla cell is replenished each hair cycle from bipotent hair follicle dermal stem cells in the dermal sheath that simultaneously self-renew and contribute progeny to the papilla, particularly during anagen."], "t": []}], "preferred_name": "hair follicle dermal papilla cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1266873", "l": "Urinary bladder epithelial cell", "d": [], "t": []}, {"i": "SNOMEDCT:115596003", "l": "", "d": [], "t": []}], "preferred_name": "Urinary bladder epithelial cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0020064", "l": "tuft cell of sublingual gland", "d": ["A tuft cell that is part of the epithelium of the sublingual gland, localized to the ductal compartment. This cell is characterized by expression of POU2F3, consistent with tuft cell identity. Immunohistochemical analysis detected POU2F3-positive cells in normal human sublingual gland tissue (Hoki et al., 2024)."], "t": []}], "preferred_name": "tuft cell of sublingual gland", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5216216", "l": "Erythrocytes|NCnc|Pt|Pericard fld", "d": [], "t": []}], "preferred_name": "Erythrocytes|NCnc|Pt|Pericard fld", "taxa": []}
{"type": "biolink:Cell", "ic": 70.01422862627324, "identifiers": [{"i": "UMLS:C1518194", "l": "Malignant Mesothelial Cell", "d": [], "t": []}, {"i": "NCIT:C36831", "l": "Malignant Mesothelial Cell", "d": [], "t": []}], "preferred_name": "Malignant Mesothelial Cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5158933", "l": "Cerebroventricular lining cells | Cerebral spinal fluid | Cytology", "d": [], "t": []}], "preferred_name": "Cerebroventricular lining cells | Cerebral spinal fluid | Cytology", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1440326", "l": "CD49f+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:1372903009", "l": "", "d": [], "t": []}], "preferred_name": "CD49f+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4300405", "l": "Cells.chromosome region 13q14", "d": [], "t": []}], "preferred_name": "Cells.chromosome region 13q14", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4310110", "l": "SN EBF2 GABA GABAergic interneuron (Primate)", "d": ["A GABAergic interneuron of the Primates brain. These cells are located in the striatum, substantia nigra . Reference transcriptomic data for this type can be found in the dataset/taxonomy - HMBA Basal Ganglia Consensus Taxonomy in cell set Group:SN EBF2 GABA."], "t": []}], "preferred_name": "SN EBF2 GABA GABAergic interneuron (Primate)", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5666839", "l": "SUPLEXA Therapeutic Cells", "d": [], "t": []}], "preferred_name": "SUPLEXA Therapeutic Cells", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4505326", "l": "Dendritic Epithelial T Cells", "d": [], "t": []}], "preferred_name": "Dendritic Epithelial T Cells", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0009033", "l": "plasma cell of appendix", "d": ["A plasma cell that is located in a vermiform appendix."], "t": []}], "preferred_name": "plasma cell of appendix", "taxa": []}
{"type": "biolink:Cell", "ic": 89.40238429118027, "identifiers": [{"i": "CL:0017000", "l": "pulmonary ionocyte", "d": ["An ionocyte that is part of the lung epithelium. The cells from this type are major sources of the CFTR protein in human and mice."], "t": []}], "preferred_name": "pulmonary ionocyte", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C2736935", "l": "CD56+CD138+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:1373044002", "l": "", "d": [], "t": []}], "preferred_name": "CD56+CD138+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": 73.49439205968403, "identifiers": [{"i": "UMLS:C1514028", "l": "Neoplastic Monocytoid B-Lymphocyte", "d": [], "t": []}, {"i": "NCIT:C37003", "l": "Neoplastic Monocytoid B-Lymphocyte", "d": [], "t": []}], "preferred_name": "Neoplastic Monocytoid B-Lymphocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0002302", "l": "type A synovial cell", "d": ["A synovial cell that is macrophage-like, characterized by surface ruffles or lamellipodia, plasma membrane invaginations and associated micropinocytotic vesicles, Golgi apparatus and little granular endoplasmic reticulum."], "t": []}, {"i": "UMLS:C0933803", "l": "Type A synoviocyte", "d": [], "t": []}], "preferred_name": "type A synovial cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5561413", "l": "Stratagraft", "d": [], "t": []}], "preferred_name": "Stratagraft", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5380996", "l": "Cells.CD8.HLA-A2 CMV specific.CMV antigen stimulated gamma interferon producing", "d": [], "t": []}], "preferred_name": "Cells.CD8.HLA-A2 CMV specific.CMV antigen stimulated gamma interferon producing", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5446661", "l": "Autologous Anti-mesothelin TCR-expressing T-cells FH-TCR TMSLN", "d": [], "t": []}, {"i": "NCIT:C175659", "l": "Autologous Anti-mesothelin TCR-expressing T-cells FH-TCR TMSLN", "d": ["A preparation of autologous T-lymphocytes that have been genetically engineered to express a T-cell receptor (TCR) specific for the tumor-associated antigen (TAA) human mesothelin (TMSLN), with potential immunomodulating and antineoplastic activities. Upon administration, the autologous anti-mesothelin TCR-expressing T-cells FH-TCR TMSLN specifically target and bind to mesothelin-expressing tumor cells. This leads to T-cell activation and T-cell mediated lysis of mesothelin-expressing tumor cells. Mesothelin, a cell surface glycoprotein involved in cell adhesion, is overexpressed in a variety of cancer cell types."], "t": []}], "preferred_name": "Autologous Anti-mesothelin TCR-expressing T-cells FH-TCR TMSLN", "taxa": []}
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{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C3485979", "l": "Allogeneic Cells", "d": [], "t": []}, {"i": "MESH:D000078422", "l": "Allogeneic Cells", "d": [], "t": []}], "preferred_name": "Allogeneic Cells", "taxa": []}
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{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5171960", "l": "Malignant cells | Body fluid | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Malignant cells | Body fluid | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0000560", "l": "band form neutrophil", "d": ["A late neutrophilic metamyelocyte in which the nucleus is indented to more than half the distance to the farthest nuclear margin but in no area being condensed to a single filament. The nucleus is in the form of a curved or coiled band, not having acquired the typical multilobar shape of the mature neutrophil. These cells are fMLP receptor-positive, CD11b-positive, CD35-negative, and CD49d-negative."], "t": []}], "preferred_name": "band form neutrophil", "taxa": []}
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{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5448075", "l": "LentiGlobin Drug Product for SCD", "d": [], "t": []}], "preferred_name": "LentiGlobin Drug Product for SCD", "taxa": []}
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{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4505244", "l": "Suprachiasmatic Nucleus Cells", "d": [], "t": []}], "preferred_name": "Suprachiasmatic Nucleus Cells", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4072014", "l": "tanycyte of vascular organ of lamina terminalis", "d": ["A specialized, non-ciliated ependymal glial cell located in the ventricular wall of the organum vasculosum of the lamina terminalis (OVLT) and characterized by elongated basal processes extending into the parenchyma to contact fenestrated capillaries. In mice, it is characterised by the expression of tight junction proteins (claudin 1, occludin, ZO-1) forming a continuous honeycomb junctional pattern. This cell contributes to a functional blood–cerebrospinal fluid (CSF) barrier at the ventricular interface of the OVLT."], "t": []}], "preferred_name": "tanycyte of vascular organ of lamina terminalis", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4241340", "l": "Set of enteroendocrine cells of epithelium of stomach", "d": [], "t": []}], "preferred_name": "Set of enteroendocrine cells of epithelium of stomach", "taxa": []}
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{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1440365", "l": "CD88+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:1372940001", "l": "", "d": [], "t": []}], "preferred_name": "CD88+ cell", "taxa": []}
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{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0427530", "l": "Lymphosarcoma cell", "d": [], "t": []}, {"i": "SNOMEDCT:250289002", "l": "", "d": [], "t": []}], "preferred_name": "Lymphosarcoma cell", "taxa": []}
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{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0002284", "l": "type X enteroendocrine cell", "d": ["An enteroendocrine cell found in the fundus and pylorus; this cell type has dense round secretory granules that contain ghrelin."], "t": []}, {"i": "UMLS:C2336812", "l": "Type X enteroendocrine cell", "d": [], "t": []}], "preferred_name": "type X enteroendocrine cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C3826976", "l": "IL-12-expressing Mesenchymal Stem Cell Vaccine GX-051", "d": [], "t": []}, {"i": "NCIT:C114385", "l": "IL-12-expressing Mesenchymal Stem Cell Vaccine GX-051", "d": ["Human mesenchymal stem cells (MSCs) transduced with a retroviral vector encoding a modified form of the cytokine interleukin-12 (IL-12), with potential immunomodulating and antineoplastic activities. Upon intratumoral administration, IL-12-expressing MSC vaccine GX-051 secretes IL-12. IL-12 activates the immune system by both promoting the secretion of interferon-gamma, which activates natural killer cells (NKs), and inducing cytotoxic T-cell responses, which may result in both decreased cell proliferation and increased cell death in tumor cells."], "t": []}], "preferred_name": "IL-12-expressing Mesenchymal Stem Cell Vaccine GX-051", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4033079", "l": "cycling endothelial cell of lymphatic vessel", "d": ["A(n) endothelial cell of lymphatic vessel that is cycling."], "t": []}], "preferred_name": "cycling endothelial cell of lymphatic vessel", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0002557", "l": "fibroblast of pulmonary artery", "d": ["A fibroblast of pulmonary artery."], "t": []}], "preferred_name": "fibroblast of pulmonary artery", "taxa": []}
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{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5783504", "l": "Autologous Tumor Infiltrating Lymphocytes C-TIL052A", "d": [], "t": []}, {"i": "NCIT:C190116", "l": "Autologous Tumor Infiltrating Lymphocytes C-TIL052A", "d": ["A preparation of autologous tumor infiltrating lymphocytes (TILs) derived from each patient's resected tumor and expanded ex vivo, with potential immunomodulating and antineoplastic activities. Upon administration back into the patient, the autologous TILs C-TIL052A specifically recognize and kill the patient's tumor cells."], "t": []}], "preferred_name": "Autologous Tumor Infiltrating Lymphocytes C-TIL052A", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1440259", "l": "Cell positive for CD16 antigen and negative for CD57 antigen", "d": [], "t": []}, {"i": "SNOMEDCT:1373168008", "l": "", "d": [], "t": []}], "preferred_name": "Cell positive for CD16 antigen and negative for CD57 antigen", "taxa": []}
{"type": "biolink:Cell", "ic": 65.84278220428874, "identifiers": [{"i": "CL:0000624", "l": "CD4-positive, alpha-beta T cell", "d": ["A mature alpha-beta T cell that expresses an alpha-beta T cell receptor and the CD4 coreceptor."], "t": []}], "preferred_name": "CD4-positive, alpha-beta T cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C4725105", "l": "CD33-specific CAR Lentiviral Vector-transduced Autologous T-lymphocytes", "d": [], "t": []}, {"i": "NCIT:C148530", "l": "CD33-specific CAR Lentiviral Vector-transduced Autologous T-lymphocytes", "d": ["Autologous T-lymphocytes transduced with a lentiviral vector expressing a chimeric antigen receptor (CAR) specific for the CD33 antigen, with potential immunomodulating and antineoplastic activities. Upon transfusion, CD33-specific CAR lentiviral vector-transduced autologous T-lymphocytes target and induce selective toxicity in CD33-expressing tumor cells. CD33 is expressed on normal non-pluripotent hematopoietic stem cells and on myeloid leukemia cells."], "t": []}], "preferred_name": "CD33-specific CAR Lentiviral Vector-transduced Autologous T-lymphocytes", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C4724838", "l": "iC9-GD2-CAR-CD28-OX40-expressing Autologous NKT Cells", "d": [], "t": []}, {"i": "NCIT:C148135", "l": "iC9-GD2-CAR-CD28-OX40-expressing Autologous NKT Cells", "d": ["A preparation of autologous interleukin-15 (IL-15)-expressing natural killer T-cells (NKT) transduced with a retroviral vector encoding a chimeric antigen receptor (CAR) derived from the antibody 14G2a that recognizes disialoganglioside GD2 (GD2-CAR) that is coupled to the co-stimulatory domains of CD28 and OX40 (CD134), and to the zeta chain of the TCR/CD3 complex (CD3-zeta), and linked to the suicide gene inducible caspase 9 (iCasp9 or iC9), with potential immunomodulating and antineoplastic activities. Upon transfusion, the iC9-GD2-CAR-CD28-OX40-expressing autologous NKT cells recognize, bind to and induce selective cytotoxicity in GD2-expressing tumor cells. The tumor-associated antigen (TAA) GD2 is overexpressed on the surface of neuroblastoma cells and by other neuroectoderm-derived neoplasms, while it is minimally expressed on normal, healthy cells. The iCasp9 safety switch consists of a full-length caspase 9, including its caspase recruitment domain, linked to a human FK506 drug-binding domain with an F36V mutation (FKBP12-F36V). If the administered NKT cells lead to unacceptable side effects, the chemical homodimerizer AP1903, which binds to the FKBP12-F36V drug-binding domain, activates caspase 9, and results in apoptosis of the administered NKT cells, can be administered."], "t": []}], "preferred_name": "iC9-GD2-CAR-CD28-OX40-expressing Autologous NKT Cells", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C2350831", "l": "Retinal Photoreceptor Cells", "d": [], "t": []}], "preferred_name": "Retinal Photoreceptor Cells", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "CL:0002441", "l": "CD94-positive natural killer cell, mouse", "d": ["A NK1.1-positive T cell that is CD94-positive."], "t": []}], "preferred_name": "CD94-positive natural killer cell, mouse", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4696708", "l": "CD19+CD38+IgM+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:1373154001", "l": "", "d": [], "t": []}], "preferred_name": "CD19+CD38+IgM+ cell", "taxa": []}
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{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5178306", "l": "Promyelocytes | Blood | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Promyelocytes | Blood | Hematology and Cell counts", "taxa": []}
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{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5853637", "l": "Natural Regulatory T Cells (T-Regs), Expanded with Interleukin-2, ExpAct Beads (CD3/CD28; Miltenyi), Rapamycin and Transforming Growth Factor-beta", "d": [], "t": []}], "preferred_name": "Natural Regulatory T Cells (T-Regs), Expanded with Interleukin-2, ExpAct Beads (CD3/CD28; Miltenyi), Rapamycin and Transforming Growth Factor-beta", "taxa": []}
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{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C2326151", "l": "Set of erythrocytes", "d": [], "t": []}], "preferred_name": "Set of erythrocytes", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4324141", "l": "Wasserhelle cell", "d": [], "t": []}], "preferred_name": "Wasserhelle cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1440286", "l": "CD3+CD7+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:1373016003", "l": "", "d": [], "t": []}], "preferred_name": "CD3+CD7+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1513923", "l": "Neoplastic Acidophilic Stem Cell", "d": [], "t": []}, {"i": "NCIT:C36924", "l": "Neoplastic Acidophilic Stem Cell", "d": [], "t": []}], "preferred_name": "Neoplastic Acidophilic Stem Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 89.40238429118027, "identifiers": [{"i": "UMLS:C1709164", "l": "Neoplastic Blast Coexpressing Myeloid and Lymphoid Lineage Antigens", "d": [], "t": []}, {"i": "NCIT:C42875", "l": "Neoplastic Blast Coexpressing Myeloid and Lymphoid Lineage Antigens", "d": [], "t": []}], "preferred_name": "Neoplastic Blast Coexpressing Myeloid and Lymphoid Lineage Antigens", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4245840", "l": "Set of regular cardiac myocytes", "d": [], "t": []}], "preferred_name": "Set of regular cardiac myocytes", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0228007", "l": "Prespermatogonia", "d": [], "t": []}, {"i": "SNOMEDCT:64216006", "l": "", "d": [], "t": []}], "preferred_name": "Prespermatogonia", "taxa": []}
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{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C6052167", "l": "Autologous Anti-B7-H3 CAR T-cells TX103", "d": [], "t": []}, {"i": "NCIT:C218851", "l": "Autologous Anti-B7-H3 CAR T-cells TX103", "d": ["A preparation of autologous T-lymphocytes that have been genetically engineered to express a chimeric antigen receptor (CAR) targeting the immunoregulatory protein B7-homologue 3 (B7-H3, CD276), with potential immunostimulating and antineoplastic activities. Upon infusion back into the patient, autologous anti-B7-H3 CAR T-cells TX103 target and bind to B7-H3-expressing tumor cells, thereby inducing selective toxicity in B7-H3-expressing tumor cells. B7-H3, a type I transmembrane protein and a member of the B7 co-stimulatory protein superfamily, is overexpressed on certain tumor cell types and on various immune cells. It is a negative regulator of the T-cell activation and its overexpression plays a key role in tumor cell invasion and metastasis."], "t": []}], "preferred_name": "Autologous Anti-B7-H3 CAR T-cells TX103", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1512134", "l": "ES05", "d": [], "t": []}, {"i": "NCIT:C20253", "l": "ES05", "d": ["Provider: ES Cell International Pte Ltd., Melbourne, Australia. Information from provider and not independently verified by NIH: Undergoing characterization. This cell line meets the criteria for the use of human embryonic stem cells by federally funded researchers."], "t": []}], "preferred_name": "ES05", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5161801", "l": "Cytoplasmic CD3 blasts | Blood | Cell markers", "d": [], "t": []}], "preferred_name": "Cytoplasmic CD3 blasts | Blood | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4033110", "l": "middle cervical ganglion TH/NPY neuron", "d": ["A sympathetic neuron that has the soma located in the middle cervical ganglion and expresses the marker tyrosine hydroxylase (TH) and neuropeptide Y (NPY)."], "t": []}], "preferred_name": "middle cervical ganglion TH/NPY neuron", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4518155", "l": "Population of all spermatozoa with abnormal midpiece in portion of fluid", "d": [], "t": []}, {"i": "SNOMEDCT:725226000", "l": "", "d": [], "t": []}], "preferred_name": "Population of all spermatozoa with abnormal midpiece in portion of fluid", "taxa": []}
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{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0333739", "l": "Pinocytotic cell", "d": [], "t": []}, {"i": "SNOMEDCT:57852008", "l": "", "d": [], "t": []}], "preferred_name": "Pinocytotic cell", "taxa": []}
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{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0228074", "l": "Medium sized neuron", "d": [], "t": []}, {"i": "SNOMEDCT:5802004", "l": "", "d": [], "t": []}], "preferred_name": "Medium sized neuron", "taxa": []}
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{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4277577", "l": "A549 Cells", "d": [], "t": []}, {"i": "MESH:D000072283", "l": "A549 Cells", "d": [], "t": []}], "preferred_name": "A549 Cells", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0314583", "l": "Colony-forming unit of basophilic lineage", "d": [], "t": []}, {"i": "SNOMEDCT:445114000", "l": "", "d": [], "t": []}], "preferred_name": "Colony-forming unit of basophilic lineage", "taxa": []}
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{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0000692", "l": "terminal Schwann cell", "d": ["A neuroglial cell of the peripheral nervous system inside the basal lamina of the neuromuscular junction providing chemical and physical support to the synapse."], "t": []}], "preferred_name": "terminal Schwann cell", "taxa": []}
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{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5780042", "l": "PEI 19-187", "d": [], "t": []}], "preferred_name": "PEI 19-187", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:1000356", "l": "microfold cell of epithelium proper of duodenum", "d": ["A M cell that is part of the epithelium proper of duodenum."], "t": []}, {"i": "UMLS:C2331946", "l": "Microfold cell of epithelium proper of duodenum", "d": [], "t": []}], "preferred_name": "microfold cell of epithelium proper of duodenum", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1979668", "l": "CD19+IgD+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:732276002", "l": "", "d": [], "t": []}], "preferred_name": "CD19+IgD+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0598090", "l": "permanent cell line", "d": [], "t": []}], "preferred_name": "permanent cell line", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0002282", "l": "type TG enteroendocrine cell", "d": ["An enteroendocrine cell which produces a gastrin- and cholecystokinin-like peptide. The apical microvilli-rich plasma membrane is in open contact with the small intestine mucosa. This cell type is devoid of gastrin-17 but contains other fragments of the gastrin polypeptide."], "t": []}, {"i": "UMLS:C2328068", "l": "Type TG enteroendocrine cell", "d": [], "t": []}], "preferred_name": "type TG enteroendocrine cell", "taxa": []}
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{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0004230", "l": "diffuse bistratified amacrine cell", "d": ["A bistratified amacrine cell with a small dendritic field that has post-synaptic terminals in S1 and the border of S1-S2, and termination of a second arbor within the border of S2-S3 and S3."], "t": []}], "preferred_name": "diffuse bistratified amacrine cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4023164", "l": "globular bushy cell", "d": ["A bushy cell that receives a large number of medium-sized synapses, called modified endbulbs. Globular bushy cells extend to the superior olive on both sides of the brainstem where they give input to the bipolar neurons."], "t": []}], "preferred_name": "globular bushy cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1267966", "l": "Lymphocyte positive for CD72 antigen", "d": [], "t": []}, {"i": "SNOMEDCT:117406009", "l": "", "d": [], "t": []}], "preferred_name": "Lymphocyte positive for CD72 antigen", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5157549", "l": "CD4+CD45RA+CD45RB+CD45RC+ cells | XXX | Cell markers", "d": [], "t": []}], "preferred_name": "CD4+CD45RA+CD45RB+CD45RC+ cells | XXX | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0009064", "l": "lymph node paracortex T cell", "d": ["A T cell located in the lymph node paracortex, where macrophages and dendritic cells present antigenic peptides to these naïve T cells, stimulating them to become activated helper T cells or cytotoxic T lymphocytes."], "t": []}], "preferred_name": "lymph node paracortex T cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1267815", "l": "Lymphocyte positive for both CD2 antigen and CD26 antigen", "d": [], "t": []}, {"i": "SNOMEDCT:117518002", "l": "", "d": [], "t": []}], "preferred_name": "Lymphocyte positive for both CD2 antigen and CD26 antigen", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1268008", "l": "Eosinophilic granulocytic cell", "d": [], "t": []}, {"i": "SNOMEDCT:127916009", "l": "", "d": [], "t": []}], "preferred_name": "Eosinophilic granulocytic cell", "taxa": []}
{"type": "biolink:Cell", "ic": 57.79112104879796, "identifiers": [{"i": "UMLS:C1706683", "l": "Abnormal Germ Cell", "d": [], "t": []}, {"i": "NCIT:C54103", "l": "Abnormal Germ Cell", "d": [], "t": []}], "preferred_name": "Abnormal Germ Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 92.76600187037766, "identifiers": [{"i": "UMLS:C1881554", "l": "Malignant Giant Germ Cell", "d": [], "t": []}, {"i": "NCIT:C61385", "l": "Malignant Giant Germ Cell", "d": [], "t": []}], "preferred_name": "Malignant Giant Germ Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 84.21065366064373, "identifiers": [{"i": "UMLS:C1512977", "l": "Mammalian Cell Specimen", "d": [], "t": []}, {"i": "NCIT:C12958", "l": "Mammalian Cell Specimen", "d": ["A biospecimen consisting of cells originating from or isolated from an animal of class Mammalia."], "t": []}], "preferred_name": "Mammalian Cell Specimen", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0003048", "l": "L cone cell", "d": ["A cone cell that detects long wavelength light. Exact peak of spectra detected differs between species. In humans, spectra peaks at 564-580 nm."], "t": []}], "preferred_name": "L cone cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5159000", "l": "Chediak-Higashi cells | Blood | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Chediak-Higashi cells | Blood | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1267829", "l": "T lymphocyte positive for CD16 antigen and negative for CD57 antigen", "d": [], "t": []}, {"i": "SNOMEDCT:115415001", "l": "", "d": [], "t": []}], "preferred_name": "T lymphocyte positive for CD16 antigen and negative for CD57 antigen", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5571708", "l": "Erythrocytes.non-dysmorphic|Urine/Urine sed", "d": [], "t": []}], "preferred_name": "Erythrocytes.non-dysmorphic|Urine/Urine sed", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0002615", "l": "adipocyte of omentum tissue", "d": ["An adipocyte that is part of omentum tissue."], "t": []}], "preferred_name": "adipocyte of omentum tissue", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4006001", "l": "fibroblast of skin of scalp", "d": ["A fibroblast that is part of the skin of scalp."], "t": []}], "preferred_name": "fibroblast of skin of scalp", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4263667", "l": "T-cell naive & memory & effector (CD27 and CD45RA) subsets", "d": [], "t": []}], "preferred_name": "T-cell naive & memory & effector (CD27 and CD45RA) subsets", "taxa": []}
{"type": "biolink:Cell", "ic": 84.83823963392128, "identifiers": [{"i": "UMLS:C1707673", "l": "Dendritic Melanoma Cell", "d": [], "t": []}, {"i": "NCIT:C53275", "l": "Dendritic Melanoma Cell", "d": [], "t": []}], "preferred_name": "Dendritic Melanoma Cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1254948", "l": "C5 Lymphocyte", "d": [], "t": []}], "preferred_name": "C5 Lymphocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "CL:0000733", "l": "lymph gland plasmatocyte", "d": ["A plasmatocyte that derives from the larval lymph gland."], "t": []}], "preferred_name": "lymph gland plasmatocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0002390", "l": "uninucleate blastconidium", "d": ["A blastoconidium that has only one nucleus."], "t": []}], "preferred_name": "uninucleate blastconidium", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5186017", "l": "Blasts | Fetus | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Blasts | Fetus | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1440284", "l": "CD3+CD4+CD45RA+CD45RO- cell", "d": [], "t": []}, {"i": "SNOMEDCT:1373250000", "l": "", "d": [], "t": []}], "preferred_name": "CD3+CD4+CD45RA+CD45RO- cell", "taxa": []}
{"type": "biolink:Cell", "ic": 72.4125108737624, "identifiers": [{"i": "CL:1000450", "l": "epithelial cell of glomerular capsule", "d": ["An epithelial cell that is part of the glomerular capsule."], "t": []}, {"i": "UMLS:C1182788", "l": "Epithelial cell of glomerular capsule", "d": [], "t": []}], "preferred_name": "epithelial cell of glomerular capsule", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5154478", "l": "Basophils | Fetus | Blood | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Basophils | Fetus | Blood | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": 92.76600187037766, "identifiers": [{"i": "UMLS:C1882058", "l": "Neoplastic Sertoli Cell with Clear Cytoplasm", "d": [], "t": []}, {"i": "NCIT:C61418", "l": "Neoplastic Sertoli Cell with Clear Cytoplasm", "d": [], "t": []}], "preferred_name": "Neoplastic Sertoli Cell with Clear Cytoplasm", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "CL:0000828", "l": "thromboblast", "d": ["A progenitor cell of the thrombocyte, a nucleated blood cell involved in coagulation typically seen in birds and other non-mammalian vertebrates."], "t": []}], "preferred_name": "thromboblast", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0011015", "l": "amoeboid sperm cell", "d": ["A motile sperm cell that contain no F-actin, and their motility is powered by a dynamic filament system."], "t": []}], "preferred_name": "amoeboid sperm cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1440243", "l": "CD117 Cells", "d": [], "t": []}, {"i": "SNOMEDCT:1372824000", "l": "", "d": [], "t": []}], "preferred_name": "CD117 Cells", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4253021", "l": "Set of type A cells of pancreatic islet", "d": [], "t": []}], "preferred_name": "Set of type A cells of pancreatic islet", "taxa": []}
{"type": "biolink:Cell", "ic": 86.30756602822301, "identifiers": [{"i": "CL:1000432", "l": "conjunctival epithelial cell", "d": ["An epithelial cell that is part of the conjunctiva."], "t": []}, {"i": "UMLS:C1182611", "l": "Conjunctival epithelial cell", "d": [], "t": []}], "preferred_name": "conjunctival epithelial cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5706399", "l": "Autologous BAFF-expressing CAR T Cells LMY-920", "d": [], "t": []}, {"i": "NCIT:C187330", "l": "Autologous BAFF-expressing CAR T Cells LMY-920", "d": ["A preparation of autologous cluster of differentiation 4 (CD4) -and CD8 positive T-lymphocytes that are genetically engineered, using the non-viral transposon system, to express a chimeric antigen receptor (CAR) expressing the B-cell activating factor (BAFF) ligand and targeting BAFF receptor family members, with potential immunostimulating and antineoplastic activities. Upon administration, the autologous BAFF-expressing CAR T cells LMY-920 are directed to, specifically bind to, and induce selective toxicity in tumor cells expressing any of the three BAFF receptor family members, including BAFF receptor (BAFF-R), B-cell maturation antigen (BCMA), and transmembrane activator and calcium modulator and cyclophilin ligand interactor (TACI). Almost all B cell cancers are reported to express at least one of these three receptors which play a key role in the regulation of peripheral B-cell survival."], "t": []}], "preferred_name": "Autologous BAFF-expressing CAR T Cells LMY-920", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C2335706", "l": "Interleukin 2-activated natural killer cell", "d": [], "t": []}], "preferred_name": "Interleukin 2-activated natural killer cell", "taxa": []}
{"type": "biolink:Cell", "ic": 46.241277557611944, "identifiers": [{"i": "CL:0011005", "l": "GABAergic interneuron", "d": ["An interneuron that uses GABA as a vesicular neurotransmitter.  These interneurons are inhibitory"], "t": []}], "preferred_name": "GABAergic interneuron", "taxa": []}
{"type": "biolink:Cell", "ic": 92.76600187037766, "identifiers": [{"i": "CL:1000302", "l": "fibroblast of papillary layer of dermis", "d": ["A fibroblast that is part of the papillary layer of dermis."], "t": []}, {"i": "UMLS:C2335912", "l": "Fibroblast of papillary layer of dermis", "d": [], "t": []}], "preferred_name": "fibroblast of papillary layer of dermis", "taxa": []}
{"type": "biolink:Cell", "ic": 76.5892103226413, "identifiers": [{"i": "UMLS:C1514045", "l": "Neoplastic Neuroendocrine Polygonal Cell", "d": [], "t": []}, {"i": "NCIT:C36933", "l": "Neoplastic Neuroendocrine Polygonal Cell", "d": [], "t": []}], "preferred_name": "Neoplastic Neuroendocrine Polygonal Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 37.491507836996185, "identifiers": [{"i": "CL:0000521", "l": "fungal cell", "d": ["Any cell that in taxon some Fungi."], "t": []}], "preferred_name": "fungal cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5557410", "l": "Autologous Tumor Killer Cells", "d": [], "t": []}, {"i": "NCIT:C182001", "l": "Autologous Tumor Killer Cells", "d": ["A preparation of autologous tumor killer cells (TKCs) which consists of the innate immune cells natural killer (NK) cells and gamma delta T (gdT) cells, which are T-lymphocytes that express only gamma chain and delta chain T-cell receptors (TCRs), with potential cytolytic and antineoplastic activities. NK cells and gdT cells are isolated from the patients' peripheral blood mononuclear cells (PBMCs) and co-cultured ex vivo in a certain proportion with TKC technology. Upon administration, autologous TKCs may lyse cancer cells, and further stimulate an anti-tumor immune response."], "t": []}], "preferred_name": "Autologous Tumor Killer Cells", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5556435", "l": "Autologous Anti-gp100:154-162 TCR Tumor Infiltrating Lymphocytes", "d": [], "t": []}, {"i": "NCIT:C180517", "l": "Autologous Anti-gp100:154-162 TCR Tumor Infiltrating Lymphocytes", "d": ["A preparation of human tumor infiltrating lymphocytes (TILs) isolated from a melanoma patient and engineered to encode a T-cell receptor (TCR) specific for the amino acid 154 through 162 of the melanoma antigen glycoprotein 100 (gp100), with potential immunomodulating and antineoplastic activities. Upon intravenous administration, the autologous anti-gp100:154-162 TCR TILs may recognize and halt the growth of gp100-expressing melanoma cells."], "t": []}], "preferred_name": "Autologous Anti-gp100:154-162 TCR Tumor Infiltrating Lymphocytes", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0002116", "l": "B220-low CD38-positive unswitched memory B cell", "d": ["A B220-low CD38-positive unswitched memory B cell is a CD38-positive unswitched memory B cell that has the phenotype B220-low, CD38-positive, IgD-positive, CD138-negative, and IgG-negative."], "t": []}], "preferred_name": "B220-low CD38-positive unswitched memory B cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1317194", "l": "CD235a+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:1372820009", "l": "", "d": [], "t": []}], "preferred_name": "CD235a+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0228088", "l": "Bergmann Glia", "d": [], "t": []}, {"i": "SNOMEDCT:55306009", "l": "", "d": [], "t": []}], "preferred_name": "Bergmann Glia", "taxa": []}
{"type": "biolink:Cell", "ic": 78.54651317367835, "identifiers": [{"i": "CL:0000354", "l": "blastemal cell", "d": [], "t": []}], "preferred_name": "blastemal cell", "taxa": []}
{"type": "biolink:Cell", "ic": 89.40238429118027, "identifiers": [{"i": "UMLS:C1882044", "l": "Neoplastic Apocrine Cell with Eosinophilic Granular Cytoplasm", "d": [], "t": []}, {"i": "NCIT:C62207", "l": "Neoplastic Apocrine Cell with Eosinophilic Granular Cytoplasm", "d": [], "t": []}], "preferred_name": "Neoplastic Apocrine Cell with Eosinophilic Granular Cytoplasm", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "CL:1001575", "l": "uterine cervix squamous cell", "d": ["Squamous cell of uterine cervix epithelium."], "t": []}], "preferred_name": "uterine cervix squamous cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5978066", "l": "Colony forming unit granulocyte macrophage | Blood product unit | Hematopoietic progenitor cells | Cell markers", "d": [], "t": []}], "preferred_name": "Colony forming unit granulocyte macrophage | Blood product unit | Hematopoietic progenitor cells | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C2360310", "l": "Reticulocytes.high light scatter", "d": [], "t": []}], "preferred_name": "Reticulocytes.high light scatter", "taxa": []}
{"type": "biolink:Cell", "ic": 92.76600187037766, "identifiers": [{"i": "CL:1001142", "l": "arcuate vein cell", "d": ["Any kidney cortex vein cell that is part of some kidney arcuate vein."], "t": []}], "preferred_name": "arcuate vein cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C4682464", "l": "Autologous ACTR-CD16-CD28-expressing T-lymphocytes ACTR707", "d": [], "t": []}, {"i": "NCIT:C139730", "l": "Autologous ACTR-CD16-CD28-expressing T-lymphocytes ACTR707", "d": ["A preparation of autologous T-lymphocytes that have been genetically modified, using proprietary Antibody-Coupled T-cell Receptor (ACTR) technology, to express a chimeric protein containing, at least, the extracellular Fc receptor domain of CD16, normally found on certain immune cells, such as natural killer (NK) cells, coupled to the co-stimulatory signaling domain of CD28, with potential immunostimulating and antineoplastic activities. Upon reintroduction into the patient with co-administration of a cancer-specific antibody, the co-administered antibody targets and binds to the tumor-associated antigen (TAA) expressed on the tumor cell. In turn, the autologous ACTR-CD16-CD28-expressing T-lymphocytes ACTR707 bind to the antibody, become activated and induce the destruction of the tumor cells by a) releasing cytotoxins that directly kill cancer cells; b) releasing cytokines that trigger an immune response and recruit other immune-mediated killer cells to kill the tumor cells; c) targeting and killing adjacent tumor cells that are not bound to the antibody; d) inducing T-cell proliferation and thereby further enhancing the T-cell mediated tumor cell attack. Compared to other T-cell products, ACTR-based products do not target a specific TAA and can potentially be used in a variety of tumors because targeting is based on the specificity of the co-administered antibody."], "t": []}], "preferred_name": "Autologous ACTR-CD16-CD28-expressing T-lymphocytes ACTR707", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5216241", "l": "Leukocytes|NCnc|Pt|Synv fld", "d": [], "t": []}], "preferred_name": "Leukocytes|NCnc|Pt|Synv fld", "taxa": []}
{"type": "biolink:Cell", "ic": 66.91941036331596, "identifiers": [{"i": "CL:0000064", "l": "ciliated cell", "d": ["A cell that has a filiform extrusion of the cell surface."], "t": []}], "preferred_name": "ciliated cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0003006", "l": "G4-ON retinal ganglion cell", "d": ["A G4 retinal ganglion cell that has post sympatic terminals in sublaminar layers S3 and S4 and is depolarized by illumination of its receptive field center."], "t": []}], "preferred_name": "G4-ON retinal ganglion cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5174097", "l": "Myelocytes | Body fluid | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Myelocytes | Body fluid | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5854545", "l": "Autologous T-cells-targeting Six TAAs MT-601", "d": [], "t": []}], "preferred_name": "Autologous T-cells-targeting Six TAAs MT-601", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0002168", "l": "border cell of cochlea", "d": ["A border cell is a slender columnar cell on the medial portion of the basilar membrane."], "t": []}, {"i": "UMLS:C2325383", "l": "Border cell of cochlea", "d": [], "t": []}], "preferred_name": "border cell of cochlea", "taxa": []}
{"type": "biolink:Cell", "ic": 73.04009684703995, "identifiers": [{"i": "CL:0000731", "l": "urothelial cell", "d": ["A cell of a layer of transitional epithelium in the wall of the proximal urethra, bladder, ureter or renal pelvis, external to the lamina propria."], "t": []}], "preferred_name": "urothelial cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C4683875", "l": "Atypical Squamous Cell-Favor High-Grade Squamous Intraepithelial Lesion", "d": [], "t": []}, {"i": "NCIT:C141519", "l": "Atypical Squamous Cell-Favor High-Grade Squamous Intraepithelial Lesion", "d": ["An abnormal squamous cell found in a cervical smear with cytologic features suggestive of high-grade squamous intraepithelial lesion."], "t": []}], "preferred_name": "Atypical Squamous Cell-Favor High-Grade Squamous Intraepithelial Lesion", "taxa": []}
{"type": "biolink:Cell", "ic": 92.76600187037766, "identifiers": [{"i": "CL:0000998", "l": "CD8-alpha-negative CD11b-negative dendritic cell", "d": ["CD8-alpha-negative CD11b-negative dendritic cell is a conventional dendritic cell that is CD11b-negative, CD4-negative CD8-alpha-negative and is CD205-positive. This cell is able to cross- present antigen to CD8-alpha-positive T cells."], "t": []}], "preferred_name": "CD8-alpha-negative CD11b-negative dendritic cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0000112", "l": "columnar neuron", "d": ["A neuron of the invertebrate central nervous system. This neuron innervates the central complex (CX) of an invertebrate brain and it forms columnar patterns with its dendrites. It is involved in navigation and spatial processing."], "t": []}], "preferred_name": "columnar neuron", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "CL:0002530", "l": "immature CD1a-positive dermal dendritic cell", "d": ["An immature CD1a-positive dermal dendritic cell is CD80-low, CD86-low, and MHCII-low."], "t": []}], "preferred_name": "immature CD1a-positive dermal dendritic cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5763110", "l": "ALLOGENEIC HUMAN UMBILICAL CORD-DERIVED MESENCHYMAL STEM CELLS", "d": [], "t": []}], "preferred_name": "ALLOGENEIC HUMAN UMBILICAL CORD-DERIVED MESENCHYMAL STEM CELLS", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4316898", "l": "Segmented basophil", "d": [], "t": []}, {"i": "SNOMEDCT:30061004", "l": "", "d": [], "t": []}], "preferred_name": "Segmented basophil", "taxa": []}
{"type": "biolink:Cell", "ic": 90.871710685482, "identifiers": [{"i": "CL:4301574", "l": "CB PLI Gly-Gaba_1 Purkinje layer interneuron (Mmus)", "d": ["A Purkinje layer interneuron of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Hmga2 (Mmus), Afap1l2 (Mmus). Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Supertype:1144 CB PLI Gly-Gaba_1."], "t": []}], "preferred_name": "CB PLI Gly-Gaba_1 Purkinje layer interneuron (Mmus)", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1267845", "l": "Lymphocyte positive for CD5 antigen", "d": [], "t": []}, {"i": "SNOMEDCT:116854001", "l": "", "d": [], "t": []}], "preferred_name": "Lymphocyte positive for CD5 antigen", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5814372", "l": "L.acidophil,brevis,casei,sal/B.anim,bifid/Lactococcus lactis 15 billion cell ORAL POWDER IN PACKET (EA)", "d": [], "t": []}], "preferred_name": "L.acidophil,brevis,casei,sal/B.anim,bifid/Lactococcus lactis 15 billion cell ORAL POWDER IN PACKET (EA)", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1440382", "l": "Cells.cytoplasmic Ig mu", "d": [], "t": []}], "preferred_name": "Cells.cytoplasmic Ig mu", "taxa": []}
{"type": "biolink:Cell", "ic": 88.20185721311867, "identifiers": [{"i": "CL:1000480", "l": "transitional myocyte of internodal tract", "d": ["A transitional myocyte that is part of the internodal tract."], "t": []}, {"i": "UMLS:C2334698", "l": "Transitional myocyte of internodal tract", "d": [], "t": []}], "preferred_name": "transitional myocyte of internodal tract", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0000411", "l": "Caenorhabditis hypodermal cell", "d": ["An epithelial cell of the hypodermis of Caenorhabditis."], "t": []}], "preferred_name": "Caenorhabditis hypodermal cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1440322", "l": "CD49b+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:1372899002", "l": "", "d": [], "t": []}], "preferred_name": "CD49b+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:1000350", "l": "basal cell of epithelium of terminal bronchiole", "d": ["A basal cell that is part of the epithelium of terminal bronchiole."], "t": []}, {"i": "UMLS:C2327656", "l": "Basal cell of epithelium of terminal bronchiole", "d": [], "t": []}], "preferred_name": "basal cell of epithelium of terminal bronchiole", "taxa": []}
{"type": "biolink:Cell", "ic": 75.38868324457971, "identifiers": [{"i": "UMLS:C1510722", "l": "Abnormal Erythroblast", "d": [], "t": []}, {"i": "NCIT:C37057", "l": "Abnormal Erythroblast", "d": [], "t": []}], "preferred_name": "Abnormal Erythroblast", "taxa": []}
{"type": "biolink:Cell", "ic": 81.34422831136257, "identifiers": [{"i": "CL:0005018", "l": "ghrelin secreting cell", "d": ["A cell that secretes ghrelin, the peptide hormone that stimulates hunger."], "t": []}], "preferred_name": "ghrelin secreting cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:2000090", "l": "dentate gyrus of hippocampal formation stellate cell", "d": ["Any stellate cell that is part of a dentate gyrus of hippocampal formation."], "t": []}], "preferred_name": "dentate gyrus of hippocampal formation stellate cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5856664", "l": "CD3+/CD19+ Cell-depleted Autologous Hematopoietic Stem Cells", "d": [], "t": []}, {"i": "NCIT:C201219", "l": "CD3+/CD19+ Cell-depleted Autologous Hematopoietic Stem Cells", "d": ["A preparation of autologous hematopoietic stem cells (HSCs) that have been selectively depleted of CD3-positive (CD3+) T-cells and CD19-positive (CD19+) B-cells, with potential immune reconstituting activity. Upon administration, the CD3+/CD19+ cell-depleted autologous HSCs are used for autologous stem cell transplant (ASCT) and may allow for rapid and sustained engraftment and immune reconstitution without the autoreactive CD3+ T-cells and CD19+ B-cells. This may alleviate manifestations of autoimmune diseases such as systemic lupus erythematosus (SLE) and systemic sclerosis."], "t": []}], "preferred_name": "CD3+/CD19+ Cell-depleted Autologous Hematopoietic Stem Cells", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5173434", "l": "Monocytes | Fetus | Blood | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Monocytes | Fetus | Blood | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": 66.62294433047852, "identifiers": [{"i": "CL:0002608", "l": "hippocampal neuron", "d": ["A neuron with a soma found in the hippocampus."], "t": []}], "preferred_name": "hippocampal neuron", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4072762", "l": "Cells.CCND1 gene", "d": [], "t": []}], "preferred_name": "Cells.CCND1 gene", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C4763554", "l": "Allogeneic HAdV Antigen-specific T-lymphocytes", "d": [], "t": []}, {"i": "NCIT:C157341", "l": "Allogeneic HAdV Antigen-specific T-lymphocytes", "d": ["A population of allogeneic T-lymphocytes specifically reactive to human adenovirus (HAdV) with potential antiviral activity. Allogeneic HAdV antigen-specific T-cells are prepared via ex vivo stimulation of donor-derived peripheral blood mononuclear cells (PBMCs) with HAdV hexon protein. T-cells that secrete interferon (IFN)-gamma in response to HAdV antigen exposure are selected and expanded for administration. Infusion of the HAdV antigen-specific T-lymphocytes into hematopoietic stem cell transplant (HSCT) patients infected with HAdV may potentially reconstitute virus-specific responses, thereby controlling HAdV infections."], "t": []}], "preferred_name": "Allogeneic HAdV Antigen-specific T-lymphocytes", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5707658", "l": "Autologous Anti-H3.3K27M TCR-expressing T-cells", "d": [], "t": []}, {"i": "NCIT:C188203", "l": "Autologous Anti-H3.3K27M TCR-expressing T-cells", "d": ["A preparation of autologous T-lymphocytes that have been genetically engineered to express a T-cell receptor (TCR) specific for the histone H3.3 containing the amino acid substitution mutation lysine (Lys) 27-to-methionine (H3.3K27M), with potential immunomodulating and antineoplastic activities. Upon administration, the autologous anti-H3.3K27M TCR-expressing T-cells specifically target and bind to H3.3K27M-expressing tumor cells. This leads to T-cell activation and T-cell mediated lysis of H3.3K27M-expressing tumor cells. The H3.3K27M mutation alters the methylation and acetylation profile of the histone H3 variant H3.3 at Lys 27. Modification of H3.3 at Lys 27 regulates gene expression, and the H3.3K27M mutation occurs in a variety of cancer cell types."], "t": []}], "preferred_name": "Autologous Anti-H3.3K27M TCR-expressing T-cells", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4518166", "l": "Population of all spermatozoa with duplicate head in portion of fluid", "d": [], "t": []}, {"i": "SNOMEDCT:725247001", "l": "", "d": [], "t": []}], "preferred_name": "Population of all spermatozoa with duplicate head in portion of fluid", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0008045", "l": "tanycyte of subcommissural organ", "d": ["A tanycyte of the subcommisural organ (SCO).  These cells extend long and slender fibers extending from their cell bodies in the ependyma toward fenestrated capillaries associated with the SCO, where they form a dense network surrounding these capillaries."], "t": []}], "preferred_name": "tanycyte of subcommissural organ", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C3896982", "l": "Autologous CD123CAR-CD28-CD3zeta-EGFRt-expressing T Lymphocytes", "d": [], "t": []}, {"i": "NCIT:C116329", "l": "Autologous CD123CAR-CD28-CD3zeta-EGFRt-expressing T Lymphocytes", "d": ["A preparation of genetically modified autologous T-cells transduced with a replication incompetent, self-inactivating lentiviral vector expressing a hinge-optimized, chimeric antigen receptor (CAR), containing a CD28 co-stimulatory signaling domain fused to CD3 zeta, the single-chain variable fragment of CD123 (Interleukin-3 receptor alpha chain or IL3RA) antigen, and a truncated form of the human epidermal growth factor receptor (EGFRt), with potential immunostimulating and antineoplastic activities. Upon intravenous administration, autologous CD123CAR-CD28-CD3zeta-EGFRt-expressing T Lymphocytes are directed to and induce selective toxicity in CD123-expressing tumor cells. CD123 is normally expressed on committed blood progenitor cells in the bone marrow; its overexpression is associated with increased leukemic cell proliferation and aggressiveness. Devoid of both ligand binding domains and tyrosine kinase activity, EGFRt both facilitates detection of the administered T-cells in vivo and can promote elimination of those cells following a cetuximab-induced antibody-dependent cellular cytotoxicity response. The costimulatory signaling domain enhances both proliferation of T-cells and antitumor activity. Hinge optimization prevents recognition of the CAR by Fc receptors (FcRs)."], "t": []}], "preferred_name": "Autologous CD123CAR-CD28-CD3zeta-EGFRt-expressing T Lymphocytes", "taxa": []}
{"type": "biolink:Cell", "ic": 90.871710685482, "identifiers": [{"i": "CL:0002203", "l": "tuft cell of large intestine", "d": ["A tuft cell that is part of the epithelium of large intestine."], "t": []}, {"i": "UMLS:C2329382", "l": "Brush cell of epithelium proper of large intestine", "d": [], "t": []}], "preferred_name": "tuft cell of large intestine", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5555352", "l": "Peripheral Blood Mononuclear Cell Sample", "d": [], "t": []}, {"i": "NCIT:C178965", "l": "Peripheral Blood Mononuclear Cell Sample", "d": ["A sample of peripheral blood mononuclear cells."], "t": []}], "preferred_name": "Peripheral Blood Mononuclear Cell Sample", "taxa": []}
{"type": "biolink:Cell", "ic": 69.35521219301899, "identifiers": [{"i": "CL:2000019", "l": "compound eye photoreceptor cell", "d": ["Any photoreceptor cell that is part of a compound eye."], "t": []}], "preferred_name": "compound eye photoreceptor cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0312864", "l": "Sensitized cell", "d": [], "t": []}, {"i": "SNOMEDCT:52976009", "l": "", "d": [], "t": []}], "preferred_name": "Sensitized cell", "taxa": []}
{"type": "biolink:Cell", "ic": 85.53200374075534, "identifiers": [{"i": "CL:4029001", "l": "gamete-nursing cell", "d": ["A cell that supports the development of a gamete by providing it cytoplasmic material (including entire organelles) by direct cross-membrane channels (del Pino, 2021)."], "t": []}], "preferred_name": "gamete-nursing cell", "taxa": []}
{"type": "biolink:Cell", "ic": 60.81698926956468, "identifiers": [{"i": "CL:0000838", "l": "lymphoid lineage restricted progenitor cell", "d": ["A progenitor cell restricted to the lymphoid lineage."], "t": []}], "preferred_name": "lymphoid lineage restricted progenitor cell", "taxa": []}
{"type": "biolink:Cell", "ic": 37.602623006943254, "identifiers": [{"i": "UMLS:C0334227", "l": "Malignant neoplasm cell", "d": [], "t": []}, {"i": "NCIT:C12917", "l": "Malignant Cell", "d": ["Cells of, or derived from, a malignant tumor."], "t": []}, {"i": "SNOMEDCT:88400008", "l": "", "d": [], "t": []}], "preferred_name": "Malignant neoplasm cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4518175", "l": "Population of all immature granulocytes in portion of fluid", "d": [], "t": []}, {"i": "SNOMEDCT:726595000", "l": "", "d": [], "t": []}], "preferred_name": "Population of all immature granulocytes in portion of fluid", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1267846", "l": "Lymphocyte positive for CD5 antigen and negative for CD2 antigen", "d": [], "t": []}, {"i": "SNOMEDCT:117533005", "l": "", "d": [], "t": []}], "preferred_name": "Lymphocyte positive for CD5 antigen and negative for CD2 antigen", "taxa": []}
{"type": "biolink:Cell", "ic": 92.76600187037766, "identifiers": [{"i": "CL:4301582", "l": "CBX Purkinje Gaba_1 Purkinje cell (Mmus)", "d": ["A Purkinje cell of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Pcp2 (Mmus), Stk17b (Mmus). Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Supertype:1152 CBX Purkinje Gaba_1."], "t": []}], "preferred_name": "CBX Purkinje Gaba_1 Purkinje cell (Mmus)", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C3495991", "l": "C2 adrenaline cells", "d": [], "t": []}], "preferred_name": "C2 adrenaline cells", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C2981629", "l": "Anti-CD19-CAR Retroviral Vector-Transduced Autologous T Cells", "d": [], "t": []}, {"i": "NCIT:C88055", "l": "Anti-CD19-CAR Retroviral Vector-Transduced Autologous T Cells", "d": ["A preparation of autologous peripheral blood T-lymphocytes (PBTL) that have been genetically modified to express a chimeric antigen receptor (CAR) consisting of an anti-CD19 scFv (single chain variable fragment) coupled to the costimulatory signaling domain CD28 and the zeta chain of the T-cell receptor (TCR)/CD3 complex (CD3 zeta), with potential immunostimulating and antineoplastic activities. Upon administration, anti-CD19-CAR retroviral vector-transduced autologous T cells direct the T-lymphocytes to CD19-expressing tumor cells, thereby inducing selective toxicity in CD19-expressing tumor cells. CD19 antigen is a B-cell specific cell surface antigen expressed in all B-cell lineage malignancies. CD3 zeta is one of several membrane-bound polypeptides found in the TCR/CD3 complex, which regulates both the assembly of complete TCR complexes and their expression on the cell surface. CD28 is essential for CD4+ T-cell proliferation, interleukin-2 production, and T-helper type-2 (Th2) development."], "t": []}], "preferred_name": "Anti-CD19-CAR Retroviral Vector-Transduced Autologous T Cells", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5908090", "l": "Rapcabtagene Autoleucel", "d": [], "t": []}], "preferred_name": "Rapcabtagene Autoleucel", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "CL:0000997", "l": "immature CD8-alpha-negative CD11b-positive dendritic cell", "d": ["Immature CD8-alpha-negative CD11b-positive dendritic cell is a CD8-alpha-negative CD11b-positive dendritic cell that is CD80-low, CD86-low, and MHCII-low."], "t": []}], "preferred_name": "immature CD8-alpha-negative CD11b-positive dendritic cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5783718", "l": "Nulabeglogene Autogedtemcel", "d": [], "t": []}, {"i": "NCIT:C190451", "l": "Nulabeglogene Autogedtemcel", "d": [], "t": []}], "preferred_name": "Nulabeglogene Autogedtemcel", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0229215", "l": "Horizontal cells of retina", "d": [], "t": []}, {"i": "SNOMEDCT:29729006", "l": "", "d": [], "t": []}], "preferred_name": "Horizontal cells of retina", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5178300", "l": "Promonocytes | Blood | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Promonocytes | Blood | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4023052", "l": "Betz upper motor neuron", "d": ["A Betz cell that synapses with lower motor neurons directly."], "t": []}], "preferred_name": "Betz upper motor neuron", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1306700", "l": "Platycyte", "d": [], "t": []}], "preferred_name": "Platycyte", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5219007", "l": "Erythrocytes|PrThr|Urine", "d": [], "t": []}], "preferred_name": "Erythrocytes|PrThr|Urine", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0231011", "l": "Ootid", "d": [], "t": []}, {"i": "SNOMEDCT:49268005", "l": "", "d": [], "t": []}], "preferred_name": "Ootid", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4072037", "l": "L2/3 intratelencephalic projecting glutamatergic neuron (Homo sapiens)", "d": ["A transcriptomically distinct intratelencephalic-projecting glutamatergic neuron with a soma found between cortical layer 2-4. This intratelencephalic-projecting glutamatergic neuron has thin-tufted apical dendrites and extends its axonal projection into L5 in the neocortex. This neuronal type has a hyperpolarised resting membrane potential. The standard transcriptomic reference data for this cell type can be found on the CellxGene census under the collection: 'Transcriptomic cytoarchitecture reveals principles of human neocortex organization', dataset: 'Supercluster: IT-projecting excitatory neurons', Author Categories: 'CrossArea_subclass', clusters L2/3 IT."], "t": []}], "preferred_name": "L2/3 intratelencephalic projecting glutamatergic neuron (Homo sapiens)", "taxa": []}
{"type": "biolink:Cell", "ic": 68.20715287354084, "identifiers": [{"i": "UMLS:C1708905", "l": "Malignant Skeletal Muscle Cell", "d": [], "t": []}, {"i": "NCIT:C49197", "l": "Malignant Skeletal Muscle Cell", "d": ["A malignant mesenchymal cell that originates from a skeletal muscle cell."], "t": []}], "preferred_name": "Malignant Skeletal Muscle Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0004125", "l": "retinal ganglion cell C2 inner", "d": ["A retinal ganglion cell C inner that has dense dendritic diversity."], "t": []}], "preferred_name": "retinal ganglion cell C2 inner", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5163447", "l": "Eosinophils | Synovial fluid | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Eosinophils | Synovial fluid | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": 74.93438803193563, "identifiers": [{"i": "UMLS:C5856890", "l": "Therapeutic Hematopoietic Stem Cells", "d": [], "t": []}, {"i": "NCIT:C201554", "l": "Therapeutic Hematopoietic Stem Cells", "d": ["Any preparation of hematopoietic stem cells (HSCs)."], "t": []}], "preferred_name": "Therapeutic Hematopoietic Stem Cells", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4510886", "l": "Blast cell positive for CD127 antigen", "d": [], "t": []}, {"i": "SNOMEDCT:724302005", "l": "", "d": [], "t": []}], "preferred_name": "Blast cell positive for CD127 antigen", "taxa": []}
{"type": "biolink:Cell", "ic": 90.871710685482, "identifiers": [{"i": "CL:1000222", "l": "stomach neuroendocrine cell", "d": ["A specialised neuroendocrine cell located in the gastric mucosa that regulates digestive processes including acid secretion and gut motility. This cell stores hormones in large dense core vesicles and synaptic-like microvesicles."], "t": []}], "preferred_name": "stomach neuroendocrine cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1514655", "l": "RL07", "d": [], "t": []}, {"i": "NCIT:C20289", "l": "RL07", "d": ["Provider: Reliance Life Sciences, Mumbai, India. No information from provider. This cell line meets the criteria for the use of human embryonic stem cells by federally funded researchers."], "t": []}], "preferred_name": "RL07", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4733125", "l": "", "d": [], "t": []}], "preferred_name": "", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:1000469", "l": "myoepithelial cell of main lactiferous duct", "d": ["A myoepithelial cell that is part of the main lactiferous duct."], "t": []}], "preferred_name": "myoepithelial cell of main lactiferous duct", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0007019", "l": "epidermal mucus secreting cell", "d": [], "t": []}], "preferred_name": "epidermal mucus secreting cell", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "CL:0002471", "l": "MHC-II-negative non-classical monocyte", "d": ["Gr1-low non-classical monocyte that lacks expression of a MHC-II complex."], "t": []}], "preferred_name": "MHC-II-negative non-classical monocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1513171", "l": "Metaplastic Columnar Cell", "d": [], "t": []}, {"i": "NCIT:C37096", "l": "Metaplastic Columnar Cell", "d": [], "t": []}], "preferred_name": "Metaplastic Columnar Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 79.07356789860069, "identifiers": [{"i": "UMLS:C1517812", "l": "Leukemic Small Lymphocyte with Clumped Chromatin", "d": [], "t": []}, {"i": "NCIT:C41066", "l": "Leukemic Small Lymphocyte with Clumped Chromatin", "d": [], "t": []}], "preferred_name": "Leukemic Small Lymphocyte with Clumped Chromatin", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1267975", "l": "Lymphocyte positive for CD85 antigen", "d": [], "t": []}, {"i": "SNOMEDCT:117415002", "l": "", "d": [], "t": []}], "preferred_name": "Lymphocyte positive for CD85 antigen", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5856957", "l": "Autologous Anti-GPC2-CAR T-cells", "d": [], "t": []}, {"i": "NCIT:C201197", "l": "Autologous Anti-GPC2-CAR T-cells", "d": ["A preparation of autologous T-lymphocytes that have been genetically modified to express a chimeric antigen receptor (CAR) specific for glypican-2 (GPC2), with potential immunostimulating and antineoplastic activities. Upon administration, autologous anti-GPC2-CAR T-cells specifically target and bind to GPC2-expressing tumor cells, resulting in tumor cell lysis. GPC2, a heparan sulfate proteoglycan and a member of the glypican family, is overexpressed on certain tumor cell types while minimally expressed in normal, healthy cells."], "t": []}], "preferred_name": "Autologous Anti-GPC2-CAR T-cells", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1513020", "l": "Mature B-Lymphocyte at the Germinal Center Stage of Differentiation", "d": [], "t": []}, {"i": "NCIT:C38436", "l": "Mature B-Lymphocyte at the Germinal Center Stage of Differentiation", "d": ["A mature naive B-lymphocyte in the germinal center of secondary lymphoid organ that has had contact with an antigen and a helper T-cell."], "t": []}], "preferred_name": "Mature B-Lymphocyte at the Germinal Center Stage of Differentiation", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0684118", "l": "Early erythroblast", "d": [], "t": []}, {"i": "SNOMEDCT:115610004", "l": "", "d": [], "t": []}], "preferred_name": "Early erythroblast", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5888372", "l": "Allogeneic UCB-derived Hematopoietic Stem and Progenitor Cells NLA101", "d": [], "t": []}], "preferred_name": "Allogeneic UCB-derived Hematopoietic Stem and Progenitor Cells NLA101", "taxa": []}
{"type": "biolink:Cell", "ic": 59.32028375530532, "identifiers": [{"i": "UMLS:C0017471", "l": "Germ Cells", "d": [], "t": []}, {"i": "NCIT:C12597", "l": "Germ Cell", "d": ["Gametes, also known as sex cells or germ cells, are the cells that come together during fertilization or conception in organisms that reproduce sexually.  Their genetic complement consists of a single set of unpaired chromosomes."], "t": []}, {"i": "MESH:D005854", "l": "Germ Cells", "d": [], "t": []}, {"i": "SNOMEDCT:787781003", "l": "", "d": [], "t": []}], "preferred_name": "Germ Cells", "taxa": []}
{"type": "biolink:Cell", "ic": 92.76600187037766, "identifiers": [{"i": "UMLS:C4727589", "l": "Neoplastic Corticotroph Cell with Scarce Secretory Granules", "d": [], "t": []}, {"i": "NCIT:C154338", "l": "Neoplastic Corticotroph Cell with Scarce Secretory Granules", "d": ["A neoplastic faintly basophilic or chromophobic PAS-positive and weakly ACTH-positive cell with scant and small secretory granules seen at the ultrastructural level."], "t": []}], "preferred_name": "Neoplastic Corticotroph Cell with Scarce Secretory Granules", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5187191", "l": "Platelets^BPU", "d": [], "t": []}], "preferred_name": "Platelets^BPU", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5670737", "l": "Autologous Anti-FSHR CER-4-1BB/CD3zeta-expressing T-lymphocytes", "d": [], "t": []}, {"i": "NCIT:C186768", "l": "Autologous Anti-FSHR CER-4-1BB/CD3zeta-expressing T-lymphocytes", "d": ["A preparation of autologous human T-lymphocytes genetically modified to express a chimeric endocrine receptor (CER) targeting the human follicle stimulating hormone receptor (FSHR) and coupled to the signaling domains of 4-1BB (CD137) and CD3 zeta, with potential immunostimulatory and antineoplastic activities. Upon administration, the autologous anti-FSHR CER-4-1BB/CD3zeta-expressing T-lymphocytes target and bind to the FSHR on FSHR-expressing tumor cell surfaces, thereby killing FSHR-expressing tumor cells. FSHR is not normally expressed in healthy non-ovarian tissue, but is present on several types of ovarian, fallopian tube, or primary peritoneal cancers."], "t": []}], "preferred_name": "Autologous Anti-FSHR CER-4-1BB/CD3zeta-expressing T-lymphocytes", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5977950", "l": "Lymphocytes | Blood product unit | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Lymphocytes | Blood product unit | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4733516", "l": "Cytorex EBV", "d": [], "t": []}], "preferred_name": "Cytorex EBV", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5182767", "l": "T-cell naive and memory and effector (CD27 and CD45RA) subsets | Blood | Cell markers", "d": [], "t": []}], "preferred_name": "T-cell naive and memory and effector (CD27 and CD45RA) subsets | Blood | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1440402", "l": "Cells.t(11;22)(p13;q12.2)(WT1,EWSR1)", "d": [], "t": []}], "preferred_name": "Cells.t(11;22)(p13;q12.2)(WT1,EWSR1)", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5157238", "l": "CD10+CD19+ cells | Blood | Cell markers", "d": [], "t": []}], "preferred_name": "CD10+CD19+ cells | Blood | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1518313", "l": "Nevus Cell B-Type", "d": [], "t": []}, {"i": "NCIT:C36865", "l": "Nevus Cell B-Type", "d": [], "t": []}], "preferred_name": "Nevus Cell B-Type", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1267963", "l": "Lymphocyte positive for CD68 antigen", "d": [], "t": []}, {"i": "SNOMEDCT:117404007", "l": "", "d": [], "t": []}], "preferred_name": "Lymphocyte positive for CD68 antigen", "taxa": []}
{"type": "biolink:Cell", "ic": 82.16838616155795, "identifiers": [{"i": "CL:0000666", "l": "fenestrated endothelial cell", "d": ["An endothelial cell that has small pores, or fenestrations, which allow for the efficient exchange of substances between the blood and surrounding tissues."], "t": []}], "preferred_name": "fenestrated endothelial cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1513965", "l": "Neoplastic Fetal Epithelial Cell", "d": [], "t": []}, {"i": "NCIT:C37113", "l": "Neoplastic Fetal Epithelial Cell", "d": [], "t": []}], "preferred_name": "Neoplastic Fetal Epithelial Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 70.44381585922123, "identifiers": [{"i": "UMLS:C1518311", "l": "Nevus cell", "d": [], "t": []}, {"i": "NCIT:C25585", "l": "Nevus Cell", "d": ["A neoplastic cutaneous melanocyte that characterizes benign and atypical cutaneous neoplastic lesions called nevi."], "t": []}], "preferred_name": "Nevus cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0814997", "l": "Intestinal cell", "d": [], "t": []}], "preferred_name": "Intestinal cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5668164", "l": "CD19x22 Bicistronic CAR T-cells", "d": [], "t": []}, {"i": "NCIT:C183133", "l": "CD19x22 Bicistronic CAR T-cells", "d": ["A preparation of T-lymphocytes that have that have been transduced with a bicistronic vector encoding two distinct chimeric antigen receptors (CARs), one against the tumor-associated antigen (TAA) CD19 and the other one against the TAA CD22, with potential immunomodulating and antineoplastic activities. Upon administration, the CD19x22 bicistronic CAR T-cells target, bind to and induce selective toxicity in tumor cells expressing CD19 and CD22. CD19 and CD22, both transmembrane phosphoglycoproteins expressed on the surface of cells in the B lineage, are often overexpressed on malignant B-cells. By simultaneously targeting two B-cell antigens using two different CARs, this preparation may minimize relapse due to single antigen loss in patients with B-cell malignancies."], "t": []}], "preferred_name": "CD19x22 Bicistronic CAR T-cells", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5540451", "l": "allogeneic cultured keratinocytes and dermal fibroblasts in murine collagen", "d": [], "t": []}], "preferred_name": "allogeneic cultured keratinocytes and dermal fibroblasts in murine collagen", "taxa": []}
{"type": "biolink:Cell", "ic": 86.30756602822301, "identifiers": [{"i": "CL:0000198", "l": "pain receptor cell", "d": ["The peripheral receptor for pain. Includes receptors which are sensitive to painful mechanical stimuli, extreme heat or cold, and chemical stimuli. All mammalian nociceptors are free nerve endings."], "t": []}, {"i": "UMLS:C0028246", "l": "Nociceptors", "d": [], "t": []}, {"i": "NCIT:C13176", "l": "Nociceptor", "d": ["A free nerve ending that is a receptor for painful stimuli. (Kanner)"], "t": []}, {"i": "MESH:D009619", "l": "Nociceptors", "d": [], "t": []}, {"i": "UBERON:0035017", "l": "nociceptor nerve ending", "d": ["A peripheral terminal of a peripheral, afferent sensory pain receptor cell that is sensitive to injury or pain, usually caused by extreme thermal exposures, mechanical forces, or other noxious stimuli. The nociceptor nerve ending innervates target tissue and transduces noxious stimuli to the central nervous system via some axon(s)."], "t": []}], "preferred_name": "pain receptor cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1511548", "l": "Cryopreserved Cell", "d": [], "t": []}, {"i": "NCIT:C19314", "l": "Cryopreserved Cell", "d": ["Cells which are indefinitely maintained in a viable state at extremely low temperatures."], "t": []}], "preferred_name": "Cryopreserved Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5984566", "l": "Autologous Anti-BCMA CAR T-cells UF-KURE-BCMA", "d": [], "t": []}, {"i": "NCIT:C212900", "l": "Autologous Anti-BCMA CAR T-cells UF-KURE-BCMA", "d": ["A preparation of autologous CD4+ and CD8+ T-lymphocytes that have been transduced with a lentiviral vector (LV) encoding for a chimeric antigen receptor (CAR) specific for human B-cell maturation antigen (BCMA; tumor necrosis factor receptor superfamily member 17; TNFRSF17), with potential immunostimulating and antineoplastic activities. Upon administration, autologous anti-BCMA CAR T-cells UF-KURE-BCMA specifically recognize and induce selective toxicity in BCMA-expressing tumor cells. BCMA, a tumor specific antigen and a receptor for both a proliferation-inducing ligand (APRIL) and B-cell activating factor (BAFF), is a member of the tumor necrosis factor (TNF) receptor superfamily (TNFRSF) and plays a key role in plasma cell survival. BCMA is found on the surfaces of plasma cells and overexpressed on malignant plasma cells."], "t": []}], "preferred_name": "Autologous Anti-BCMA CAR T-cells UF-KURE-BCMA", "taxa": []}
{"type": "biolink:Cell", "ic": 89.40238429118027, "identifiers": [{"i": "UMLS:C1514002", "l": "Neoplastic Large Ganglioid Astrocyte", "d": [], "t": []}, {"i": "NCIT:C41469", "l": "Neoplastic Large Ganglioid Astrocyte", "d": [], "t": []}], "preferred_name": "Neoplastic Large Ganglioid Astrocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 73.26332733876373, "identifiers": [{"i": "UMLS:C5442137", "l": "Anti-BCMA CAR T Cells Preparation", "d": [], "t": []}, {"i": "NCIT:C176023", "l": "Anti-BCMA CAR T Cells Preparation", "d": ["A preparation of CAR-T cells that targets the tumor-associated antigen (TAA)  B-cell maturation antigen (BCMA;TNFRSF17)."], "t": []}], "preferred_name": "Anti-BCMA CAR T Cells Preparation", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1637798", "l": "Leukocyte component of blood", "d": [], "t": []}, {"i": "SNOMEDCT:419030006", "l": "", "d": [], "t": []}], "preferred_name": "Leukocyte component of blood", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5417758", "l": "Zynteglo", "d": [], "t": []}], "preferred_name": "Zynteglo", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4310129", "l": "STRd D1 Matrix medium spiny neuron (Primate)", "d": ["A matrix D1 medium spiny neuron of the Primates brain. These cells are located in the striatum . Reference transcriptomic data for this type can be found in the dataset/taxonomy - HMBA Basal Ganglia Consensus Taxonomy in cell set Group:STRd D1 Matrix MSN."], "t": []}], "preferred_name": "STRd D1 Matrix medium spiny neuron (Primate)", "taxa": []}
{"type": "biolink:Cell", "ic": 74.37365206292206, "identifiers": [{"i": "UMLS:C1513993", "l": "Neoplastic Keratinocyte", "d": [], "t": []}, {"i": "NCIT:C36749", "l": "Neoplastic Keratinocyte", "d": [], "t": []}], "preferred_name": "Neoplastic Keratinocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5667674", "l": "Autologous MGMTP140K Lentiviral Vector-transduced HSCs", "d": [], "t": []}, {"i": "NCIT:C182624", "l": "Autologous MGMTP140K Lentiviral Vector-transduced HSCs", "d": ["A preparation of autologous CD34+ hematopoietic stem cells (HSCs) transduced with a lentiviral-based proviral vector encoding for MGMTP140K, a mutant version of the human DNA repair protein O6-alkylguanine-DNA methyltransferase (MGMT), with potential protective activity against myelosuppression. MGMTP140K is resistant to the MGMT inhibitor O6-benzylguanine (O6BG; BG). Upon administration of the autologous MGMTP140K lentiviral vector-transduced HSCs back into the patient, the HSCs expressing the BG-resistant mutant MGMT protein could, when used in combination with BG, protect the hematopoietic system against the hematopoietic toxicity of BG by enabling normal methyltransferase activity. This protects hematopoiesis and allows for temozolomide (TMZ) and BG chemotherapy without myelosuppression. MGMT repairs TMZ-induced DNA methylation. The MGMT inhibitor BG depletes MGMT and thereby maximizes TMZ-mediated anti-tumor response. The depletion of MGMT in hematopoietic cells leads to unacceptable bone marrow toxicity."], "t": []}], "preferred_name": "Autologous MGMTP140K Lentiviral Vector-transduced HSCs", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5157267", "l": "CD11a blasts | XXX | Cell markers", "d": [], "t": []}], "preferred_name": "CD11a blasts | XXX | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4304487", "l": "Population of all smudge cells in portion of fluid", "d": [], "t": []}, {"i": "SNOMEDCT:719701000", "l": "", "d": [], "t": []}], "preferred_name": "Population of all smudge cells in portion of fluid", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5380990", "l": "Cells.CD8.HLA-A2 CMV specific.CMV antigen stimulated CD107a+b expressing", "d": [], "t": []}], "preferred_name": "Cells.CD8.HLA-A2 CMV specific.CMV antigen stimulated CD107a+b expressing", "taxa": []}
{"type": "biolink:Cell", "ic": 86.30756602822301, "identifiers": [{"i": "CL:0000803", "l": "CD4-negative CD8-negative gamma-delta intraepithelial T cell", "d": ["A gamma-delta intraepithelial T cell that has the phenotype CD4-negative and CD8-negative."], "t": []}], "preferred_name": "CD4-negative CD8-negative gamma-delta intraepithelial T cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C2924221", "l": "CD11c-CD103+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:1373163004", "l": "", "d": [], "t": []}], "preferred_name": "CD11c-CD103+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "UMLS:C1514085", "l": "Neoplastic Small Cell", "d": [], "t": []}, {"i": "NCIT:C37103", "l": "Neoplastic Small Cell", "d": ["A benign or malignant cell that is characterized by the presence of a small nucleus and scant amount of cytoplasm.  It may be epithelial, lymphoid, neuroepithelial, or mesenchymal in origin."], "t": []}], "preferred_name": "Neoplastic Small Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 78.54651317367835, "identifiers": [{"i": "UMLS:C1513994", "l": "Neoplastic Langerhans Cell", "d": [], "t": []}, {"i": "NCIT:C36889", "l": "Neoplastic Langerhans Cell", "d": [], "t": []}], "preferred_name": "Neoplastic Langerhans Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 82.16838616155795, "identifiers": [{"i": "CL:4023007", "l": "L2/3 bipolar VIP GABAergic interneuron (Mmus)", "d": ["A VIP GABAergic cortical interneuron with bipolar morphology, with a soma found in L2/3. L2/3 bipolar VIP cells have extending axons across all layers (with preferences for layers II/III and Va) and a dendritic tree that is vertically more restricted than deeper layer VIP cells and extend fewer dendrites into the layers outside their home layer (location of soma). L2/3 bipolar VIP cells have great variability in firing patterns, though most are continuous adapting. L2/3 bipolar VIP cells are more depolarized in their resting state, had less fast rectification, and had smaller after hyperpolarization than deeper VIP cells."], "t": []}], "preferred_name": "L2/3 bipolar VIP GABAergic interneuron (Mmus)", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0000920", "l": "CD8-positive, CD28-negative, alpha-beta regulatory T cell", "d": ["CD8-positive, alpha-beta positive regulatory T cell with the phenotype CD28-negative and FoxP3-positive."], "t": []}, {"i": "UMLS:C0039198", "l": "Regulatory T-Lymphocytes", "d": [], "t": []}, {"i": "MESH:D050378", "l": "T-Lymphocytes, Regulatory", "d": [], "t": []}], "preferred_name": "CD8-positive, CD28-negative, alpha-beta regulatory T cell", "taxa": []}
{"type": "biolink:Cell", "ic": 90.871710685482, "identifiers": [{"i": "CL:0000005", "l": "neural crest derived fibroblast", "d": ["Any fibroblast that is derived from the neural crest."], "t": []}], "preferred_name": "neural crest derived fibroblast", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5977951", "l": "Lymphocytes | Blood product unit | Hematopoietic progenitor cells | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Lymphocytes | Blood product unit | Hematopoietic progenitor cells | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C3652652", "l": "indium (111In) tropolonate labelled cells", "d": [], "t": []}], "preferred_name": "indium (111In) tropolonate labelled cells", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5557362", "l": "Autologous Anti-KK-LC-1 TCR-expressing T-cells", "d": [], "t": []}, {"i": "NCIT:C181918", "l": "Autologous Anti-KK-LC-1 TCR-expressing T-cells", "d": ["A preparation of autologous T-lymphocytes that have been genetically engineered to express a T-cell receptor (TCR) specific for the tumor-associated antigen (TAA) Kita-Kyushu lung cancer antigen-1 (KK-LC-1), with potential immunomodulating and antineoplastic activities. Upon administration, the autologous anti-KK-LC-1 TCR-expressing T-cells specifically target and bind to KK-LC-1-expressing tumor cells. This leads to T-cell activation and T-cell mediated lysis of KK-LC-1-expressing tumor cells. KK-LC-1, a cancer germline (CG) antigen, is expressed in a variety of epithelial cancers and has restricted expression in normal tissues."], "t": []}], "preferred_name": "Autologous Anti-KK-LC-1 TCR-expressing T-cells", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C2736929", "l": "CD19+CD20+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:1372975001", "l": "", "d": [], "t": []}], "preferred_name": "CD19+CD20+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5555088", "l": "Allogeneic Invariant Natural Killer T-cells agenT-797", "d": [], "t": []}, {"i": "NCIT:C178501", "l": "Allogeneic Invariant Natural Killer T-cells agenT-797", "d": ["A preparation of allogeneic, off-the shelf, natural killer T-cells (NKTs) expressing an invariant (alpha, beta) T-cell receptor (iNKTs), with potential immunomodulating and antineoplastic activities. Upon administration of allogeneic iNKT agenT-797, the invariant T-cell receptor (TCR) and natural-killer group 2, member D receptor (NKG2D; KLRK1; natural killer cell activating receptor group 2D) expressed by these cells recognize CD1d-restricted lipid ligands and stress ligands, which are expressed on certain tumor cells. These receptor-ligand interactions may induce the secretion of large amounts of various pro-inflammatory cytokines, including interferon gamma (IFN-g), and activate the immune system against tumor cells. Additionally, iNKTs directly target and lyse tumor cells."], "t": []}], "preferred_name": "Allogeneic Invariant Natural Killer T-cells agenT-797", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1440052", "l": "Abnormal blood cells.CD2", "d": [], "t": []}], "preferred_name": "Abnormal blood cells.CD2", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4304489", "l": "Population of all macrophages in portion of fluid", "d": [], "t": []}, {"i": "SNOMEDCT:719699000", "l": "", "d": [], "t": []}], "preferred_name": "Population of all macrophages in portion of fluid", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0946057", "l": "Erythrocytes.CD55", "d": [], "t": []}], "preferred_name": "Erythrocytes.CD55", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C6021867", "l": "T Lymphocytes.CD3+CD19-", "d": [], "t": []}], "preferred_name": "T Lymphocytes.CD3+CD19-", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0020026", "l": "alpha retinal ganglion cell OFF-transient (Mmus)", "d": ["An alpha retinal ganglion cell subtype found in the mouse retina that responds selectively and transiently to decreases in light intensity. It is characterized by a large soma, a broad dendritic arbor that stratifies within sublamina a of the inner plexiform layer, and rapid OFF-transient firing kinetics that decay even during sustained stimulation (Krieger et al., 2017). Functionally, it corresponds to G8 in the Baden functional classification (Baden et al., 2016; Goetz et al., 2022) and C45 in the Tran transcriptomic atlas (Tran et al., 2019), and it is considered the evolutionary ortholog of the primate OFF Parasol RGC (Hahn et al., 2023). This cell type acts as a detector of rapidly approaching dark objects and contributes to innate defensive responses by encoding looming stimuli (Münch et al., 2009). It exhibits a distinctive molecular signature by its expression of Brn3c (Krieger et al., 2017)."], "t": []}], "preferred_name": "alpha retinal ganglion cell OFF-transient (Mmus)", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0553712", "l": "Marrow monocytoid cell", "d": [], "t": []}], "preferred_name": "Marrow monocytoid cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5853684", "l": "allogeneic CRISPR/Cas9-mediated genetically modified CAR T cells targeting CD19 antigen", "d": [], "t": []}], "preferred_name": "allogeneic CRISPR/Cas9-mediated genetically modified CAR T cells targeting CD19 antigen", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4522890", "l": "T Lymphocytes, Cultured, Autologous, Genetically-modified", "d": [], "t": []}], "preferred_name": "T Lymphocytes, Cultured, Autologous, Genetically-modified", "taxa": []}
{"type": "biolink:Cell", "ic": 66.06728129612489, "identifiers": [{"i": "UMLS:C1708886", "l": "Malignant Large Germ Cell with Abundant Cytoplasm", "d": [], "t": []}, {"i": "NCIT:C54127", "l": "Malignant Large Germ Cell with Abundant Cytoplasm", "d": [], "t": []}], "preferred_name": "Malignant Large Germ Cell with Abundant Cytoplasm", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C2985406", "l": "DU 145", "d": [], "t": []}, {"i": "NCIT:C93036", "l": "DU 145", "d": ["A carcinoma cell line established from a brain metastasis from a 69 year old male patient with prostate carcinoma.  The carcinoma cells do not express PSA and are not sensitive to hormones."], "t": []}], "preferred_name": "DU 145", "taxa": []}
{"type": "biolink:Cell", "ic": 72.615132056446, "identifiers": [{"i": "CL:0000462", "l": "adepithelial cell", "d": ["A cell of mesodermal origin that is closely associated with the epithelium of an imaginal disc. It is a precursor of some of the insect's adult muscles."], "t": []}], "preferred_name": "adepithelial cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0684134", "l": "exciter neuron", "d": [], "t": []}], "preferred_name": "exciter neuron", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4052017", "l": "choroid plexus capillary endothelial cell", "d": ["A capillary endothelial cell that is part of the choroid plexus, characterized by its fenestrated nature with 60 to 80 nm fenestrations and lack of tight junctions. This fenestrated structure allows for the rapid delivery of water and other components, aiding in the production of cerebrospinal fluid (CSF)."], "t": []}], "preferred_name": "choroid plexus capillary endothelial cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0002089", "l": "group 2 innate lymphoid cell, mouse", "d": ["A group 2 innate lymphoid cell in the mouse capable of secreting IL-13 in response to a helminth infection. This cell is lineage-negative, ICOS-positive, IL1RL1-positive, IL7Ralpha-positive, and IL17Br-positive."], "t": []}], "preferred_name": "group 2 innate lymphoid cell, mouse", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5171657", "l": "Lymphocytes | Blood | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Lymphocytes | Blood | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4511163", "l": "Blast cell positive for cytoplasmic CD3 antigen", "d": [], "t": []}, {"i": "SNOMEDCT:725483008", "l": "", "d": [], "t": []}], "preferred_name": "Blast cell positive for cytoplasmic CD3 antigen", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5690872", "l": "L929 Cells", "d": [], "t": []}], "preferred_name": "L929 Cells", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5556709", "l": "Autologous Multiple Antigen-specific T-cells MASE-T", "d": [], "t": []}, {"i": "NCIT:C180908", "l": "Autologous Multiple Antigen-specific T-cells MASE-T", "d": ["A preparation of autologous T-cells targeting multiple antigens expressed by melanoma cells, with potential immunomodulating and antineoplastic activities. Peripheral blood T-cells from the patient are collected, processed with artificial antigen-presenting scaffolds, and enriched and expanded ex-vivo to generate multiple antigen-specific endogenously-derived T-cells (MASE-T) targeting multiple antigens expressed by melanoma cells. Upon administration, the autologous multiple antigen-specific T-cells MASE-T are re-introduced into the patient, where they target and kill melanoma cells expressing these specific antigens."], "t": []}], "preferred_name": "Autologous Multiple Antigen-specific T-cells MASE-T", "taxa": []}
{"type": "biolink:Cell", "ic": 80.27409497666227, "identifiers": [{"i": "UMLS:C1513953", "l": "Neoplastic Endocrine Clear Cell", "d": [], "t": []}, {"i": "NCIT:C36930", "l": "Neoplastic Endocrine Clear Cell", "d": [], "t": []}], "preferred_name": "Neoplastic Endocrine Clear Cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5184395", "l": "Unidentified cells | Blood | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Unidentified cells | Blood | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5706397", "l": "Autologous GCC-targeting CAR T Cells GCC19CART", "d": [], "t": []}, {"i": "NCIT:C187317", "l": "Autologous GCC-targeting CAR T Cells GCC19CART", "d": ["A preparation of autologous T-lymphocytes that are genetically engineered to express a chimeric antigen receptor (CAR) targeting the enterocyte differentiation antigen guanylyl cyclase C (GUCY2C) that are activated with CAR T-cells specific for the CD19 antigen, and coupled to as of yet not fully elucidated signaling domains, with potential immunostimulating and antineoplastic activities. Upon intravenous administration, the autologous GCC-targeting CAR T cells GCC19CART are directed to, specifically bind to, activate, proliferate and release cytokines that promote killing of GCC-expressing tumor cells. GCC is overexpressed in various tumor cell types. The activation of the GCC-targeting T-cells by activated CD19 CAR  that secrete cytokines, enhances CAR T-cell activation and proliferation,  and may increase the T-cell-mediated killing of GCC-expressing tumor cells."], "t": []}], "preferred_name": "Autologous GCC-targeting CAR T Cells GCC19CART", "taxa": []}
{"type": "biolink:Cell", "ic": 86.30756602822301, "identifiers": [{"i": "CL:0000861", "l": "elicited macrophage", "d": ["A macrophage which develops from an inflammatory monocyte and is recruited into the tissues in response to injury and infection as part of an inflammatory response. Markers include CD11b-positive, CD68-positive, and F4/80-positive."], "t": []}], "preferred_name": "elicited macrophage", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C3495544", "l": "A10 cell group", "d": [], "t": []}], "preferred_name": "A10 cell group", "taxa": []}
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{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0682701", "l": "Central neuron", "d": [], "t": []}], "preferred_name": "Central neuron", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5216256", "l": "Lymphoma cells|NCnc|Pt|Bld", "d": [], "t": []}], "preferred_name": "Lymphoma cells|NCnc|Pt|Bld", "taxa": []}
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{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5960714", "l": "Autologous IL-15/IL-21-armored Anti-glypican-3 CAR T-cells", "d": [], "t": []}, {"i": "NCIT:C207805", "l": "Autologous IL-15/IL-21-armored Anti-glypican-3 CAR T-cells", "d": ["A preparation of autologous T-lymphocytes that have been genetically modified to express a chimeric antigen receptor (CAR) specific for glypican-3 (GPC3), interleukin-15 (IL-15) and interleukin-21 (IL-21), with potential immunostimulating and antineoplastic activities. Upon administration, autologous IL-15/IL-21-armored anti-GPC3 CAR T-cells specifically target and bind to GPC3-expressing tumor cells, resulting in tumor cell lysis. GPC3, a heparan sulfate proteoglycan and a member of the glypican family, is overexpressed on certain tumor cell types while minimally expressed on normal, healthy cells; GPC3 plays an important role in cellular proliferation and differentiation. The cytokines IL-15 and IL-21 promote T-cell survival, expansion and persistence, which may potentiate the immune response against tumor cells."], "t": []}], "preferred_name": "Autologous IL-15/IL-21-armored Anti-glypican-3 CAR T-cells", "taxa": []}
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{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5178285", "l": "Prolymphocytes | Body fluid | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Prolymphocytes | Body fluid | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": 81.743421370964, "identifiers": [{"i": "CL:4042003", "l": "border associated macrophage", "d": ["A central nervous system macrophage that is part of a choroid plexus, a meninx and a perivascular space. A border associated macrophage interacts with various components of the CNS vasculature and meninges, it participates in immune surveillance and in the regulation of the blood brain barrier."], "t": []}], "preferred_name": "border associated macrophage", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1267797", "l": "Lymphocyte positive for CDA antigen", "d": [], "t": []}, {"i": "SNOMEDCT:117501001", "l": "", "d": [], "t": []}], "preferred_name": "Lymphocyte positive for CDA antigen", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0882939", "l": "CD8+HLA-DR+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:1373215008", "l": "", "d": [], "t": []}], "preferred_name": "CD8+HLA-DR+ cell", "taxa": []}
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{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5167637", "l": "HLA Ab positive cells | Serum | HLA antigens", "d": [], "t": []}], "preferred_name": "HLA Ab positive cells | Serum | HLA antigens", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5853963", "l": "TRK-001", "d": [], "t": []}], "preferred_name": "TRK-001", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5708969", "l": "CytoTIL15", "d": [], "t": []}], "preferred_name": "CytoTIL15", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0002463", "l": "SIRPa-positive adipose dendritic cell", "d": ["An adipose dendritic cell that is SIRPa-positive."], "t": []}], "preferred_name": "SIRPa-positive adipose dendritic cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C2698146", "l": "Anti-Her-2-CAR Retroviral Vector-Transduced Autologous Peripheral Blood Lymphocytes", "d": [], "t": []}, {"i": "NCIT:C79834", "l": "Anti-Her-2-CAR Retroviral Vector-Transduced Autologous Peripheral Blood Lymphocytes", "d": ["Autologous human peripheral blood lymphocytes (PBLs) transduced with a retroviral vector encoding an anti-Her-2 (epidermal growth factor receptor 2) chimeric T cell receptor (chimeric antigen receptor or CAR) gene with potential immunostimulatory and antineoplastic activities. Autologous PBLs from a patient with Her-2-positive cancer are pulsed with a retroviral vector that encodes the CAR gene specific for Her-2. After expansion in culture and reintroduction into the patient, anti-Her-2-CAR retroviral vector-transduced autologous peripheral blood lymphocytes, which express anti-Her-2-CAR on their cell surfaces, bind to Her-2 antigen on tumor cell surfaces. Subsequently, Her-2-expressing tumor cells may be lysed. Her-2 (ErbB-2), a receptor tyrosine kinase (RTK) overexpressed by a variety of cancer cell types, belongs to the EGFR superfamily and plays key roles in both tumor cell proliferation and tumor angiogenesis."], "t": []}], "preferred_name": "Anti-Her-2-CAR Retroviral Vector-Transduced Autologous Peripheral Blood Lymphocytes", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4033038", "l": "lung resident memory CD4-positive, alpha-beta T cell", "d": ["An alpha-beta CD4 T cell that resides in the lung."], "t": []}], "preferred_name": "lung resident memory CD4-positive, alpha-beta T cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4030012", "l": "kidney loop of Henle short descending thin limb epithelial cell", "d": ["Epithelial cell of the descending thin limb of the short loop (cortical) nephron limited to the outer medulla (mainly inner strip). It is known in some mammalian species that the short descending limb of the loop of Henle selectively expresses the serine protease Corin, the homeobox TF Uncx, and the urea channel Slc14a2."], "t": []}], "preferred_name": "kidney loop of Henle short descending thin limb epithelial cell", "taxa": []}
{"type": "biolink:Cell", "ic": 92.76600187037766, "identifiers": [{"i": "CL:4028001", "l": "pulmonary capillary endothelial cell", "d": ["Any capillary endothelial cell that is part of a lung."], "t": []}], "preferred_name": "pulmonary capillary endothelial cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5849093", "l": "Stromal Tumor Infiltrating Lymphocyte", "d": [], "t": []}, {"i": "NCIT:C200223", "l": "Stromal Tumor Infiltrating Lymphocyte", "d": ["A tumor infiltrating lymphocyte found within the boundary of a tumor but located within the intervening stroma. These cells do not infiltrate tumor nests and lack cell-cell contacts with tumor cells."], "t": []}], "preferred_name": "Stromal Tumor Infiltrating Lymphocyte", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C2333402", "l": "Ciliary ganglion neuron", "d": [], "t": []}], "preferred_name": "Ciliary ganglion neuron", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0008044", "l": "tanycyte of area postrema", "d": ["A tanycyte of the area postrema (AP).  These cells extend long and slender fibers extending from their cell bodies in the ependyma toward fenestrated capillaries associated with the AP, where they form a dense network surrounding these capillaries."], "t": []}], "preferred_name": "tanycyte of area postrema", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C4744787", "l": "Alpha/Beta T-Lymphocyte", "d": [], "t": []}, {"i": "NCIT:C156387", "l": "Alpha/Beta T-Lymphocyte", "d": ["A mature T-cell that expresses a T-cell receptor complex comprised of the highly variable alpha and beta chains complexed with the invariant CD3 antigen complex and plays a primary role in adaptive immunity."], "t": []}], "preferred_name": "Alpha/Beta T-Lymphocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4033008", "l": "vein endothelial cell of respiratory system", "d": ["A(n) vein endothelial cell that is part of a(n) respiratory system."], "t": []}], "preferred_name": "vein endothelial cell of respiratory system", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4246476", "l": "Ectomesenchymal cell", "d": [], "t": []}], "preferred_name": "Ectomesenchymal cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5238373", "l": "Allogeneic NKG2DL-targeting CAR-grafted Gamma Delta T Cells", "d": [], "t": []}, {"i": "NCIT:C167220", "l": "Allogeneic NKG2DL-targeting CAR-grafted Gamma Delta T Cells", "d": ["A preparation of a subset of allogeneic T-lymphocytes that express only gamma chain and delta chain T-cell receptors (TCRs) and that are engineered to express a chimeric antigen receptor (CAR) encoding for human natural-killer group 2, member D receptor protein (NKG2D or KLRK1; natural killer cell activating receptor group 2D), with potential immunomodulating and antineoplastic activities. Upon administration of the NKG2DL-targeting CAR-grafted gamma delta T cells, these cells specifically target and bind to tumor cells expressing NKG2D ligands (NKG2DL). This induces secretion of pro-inflammatory cytokines and results in the lysis of NKG2DL-expressing tumor cells. In addition, these cells target, bind to and kill NKG2DL-expressing tumor-associated endothelial cells in the neovasculature and immunosuppressive cells, such as regulatory T-cells (Tregs) and myeloid-derived suppressor cells (MDSCs) in the tumor microenvironment (TME) that express NKG2D ligands. Gamma/delta T-lymphocytes play a key role in the activation of the immune system and do not require major histocompatibility complex (MHC)-mediated antigen presentation to exert their cytotoxic effect. Ligands for NKG2D, such as MHC class I chain-related protein A (MICA), MICB, and members of the UL16-binding proteins (ULBP)/retinoic acid early transcript 1 (RAET1) family, are overexpressed on infected cells and most cancer cell types, but are not expressed on most normal, healthy cells."], "t": []}], "preferred_name": "Allogeneic NKG2DL-targeting CAR-grafted Gamma Delta T Cells", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C2326796", "l": "Chromophil cell of pars distalis of adenohypophysis", "d": [], "t": []}], "preferred_name": "Chromophil cell of pars distalis of adenohypophysis", "taxa": []}
{"type": "biolink:Cell", "ic": 68.05098739918701, "identifiers": [{"i": "CL:0002489", "l": "double negative thymocyte", "d": ["A thymocyte that lacks expression of CD4 and CD8."], "t": []}], "preferred_name": "double negative thymocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0004161", "l": "510 nm-cone", "d": ["A cone whose sensitivity measurements have an average spectral peak of 510 nm. These cones are described in rat."], "t": []}], "preferred_name": "510 nm-cone", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5706522", "l": "Autologous Anti-PRAME TCR/CD8alphabeta-expressing T-cells IMA203CD8", "d": [], "t": []}, {"i": "NCIT:C188985", "l": "Autologous Anti-PRAME TCR/CD8alphabeta-expressing T-cells IMA203CD8", "d": ["A preparation of autologous T-lymphocytes that are genetically modified with a lentiviral vector encoding a T-cell receptor (TCR) specific for the tumor-associated antigen (TAA) preferentially expressed antigen in melanoma (PRAME) and a CD8alphabeta (CD8ab) co-receptor, with potential immunostimulating and antineoplastic activities. Upon administration back into the patient, the autologous anti-PRAME TCR/CD8ab-expressing T-cells IMA203CD8 specifically recognize and bind to PRAME expressed on cancer cells, which induces a cytotoxic T-lymphocyte (CTL)-mediated immune response against the PRAME-expressing cancer cells. PRAME is overexpressed by a variety of cancer cell types. Co-expression of the CD8ab heterodimer may enhance anti-tumor immune response by engaging CD4+ T-cells."], "t": []}], "preferred_name": "Autologous Anti-PRAME TCR/CD8alphabeta-expressing T-cells IMA203CD8", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5447428", "l": "Autologous Anti-CD20 CAR T-cells C-CAR066", "d": [], "t": []}, {"i": "NCIT:C176772", "l": "Autologous Anti-CD20 CAR T-cells C-CAR066", "d": ["A preparation of autologous T-lymphocytes that have been genetically modified to express a chimeric antigen receptor (CAR) targeting the tumor-associated antigen (TAA) cluster of differentiation 20 (CD20), with potential immunostimulating and antineoplastic activities. Upon administration, C-CAR066 specifically recognize and kill CD20-expressing tumor cells. The CD20 antigen, a non-glycosylated cell surface phosphoprotein, is a B-cell specific cell surface antigen expressed in B-cell lineage malignancies and certain melanoma cell subpopulations."], "t": []}], "preferred_name": "Autologous Anti-CD20 CAR T-cells C-CAR066", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0333840", "l": "Non-lipid histiocyte", "d": [], "t": []}, {"i": "SNOMEDCT:42766006", "l": "", "d": [], "t": []}], "preferred_name": "Non-lipid histiocyte", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C2333098", "l": "Set of cholinergic cells of diagonal gyrus [Ch2]", "d": [], "t": []}], "preferred_name": "Set of cholinergic cells of diagonal gyrus [Ch2]", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4079018", "l": "lumbar dorsal root ganglion substance P neuron", "d": ["A peptidergic nociceptor whose soma is located in the lumbar dorsal root ganglion and that expresses substance P, an 11-amino-acid neuropeptide cleaved from protachykinin-1 (encoded by TAC1). This small-diameter neuron frequently co-expresses CGRP and belongs to the TrkA-positive peptidergic population. Upon nociceptive activation, it releases substance P both centrally in the spinal cord dorsal horn and peripherally at sensory nerve terminals, mediating neurogenic inflammation through NK1 receptor signalling (Haberberger et al. 2019, PMID:31293388). Substance P-immunoreactive neurons have been consistently identified in human DRG by immunohistochemistry across multiple studies."], "t": []}], "preferred_name": "lumbar dorsal root ganglion substance P neuron", "taxa": []}
{"type": "biolink:Cell", "ic": 75.08236434612573, "identifiers": [{"i": "CL:0011103", "l": "sympathetic neuron", "d": ["Sympathetic neurons are part of the sympathetic nervous system and are primarily adrenergic producing the neurotransmitter noradrenalin along with other neuropeptides."], "t": []}], "preferred_name": "sympathetic neuron", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1440270", "l": "CD1a+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:1372860005", "l": "", "d": [], "t": []}], "preferred_name": "CD1a+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0002521", "l": "subcutaneous adipocyte", "d": ["An adipocyte that is part of subcutaneous adipose tissue."], "t": []}], "preferred_name": "subcutaneous adipocyte", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0229568", "l": "Adrenal medullary cell", "d": [], "t": []}, {"i": "SNOMEDCT:35284004", "l": "", "d": [], "t": []}], "preferred_name": "Adrenal medullary cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5853555", "l": "allogeneic human placental hematopoietic stem cell derived natural killer (NK) cell therapy product that is genetically modified to express a variant of CD16 (CD16VP)", "d": [], "t": []}], "preferred_name": "allogeneic human placental hematopoietic stem cell derived natural killer (NK) cell therapy product that is genetically modified to express a variant of CD16 (CD16VP)", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1515148", "l": "TE06", "d": [], "t": []}, {"i": "NCIT:C20300", "l": "TE06", "d": ["Provider: Technion University, Haifa, Israel. No information from provider. This cell line meets the criteria for the use of human embryonic stem cells by federally funded researchers."], "t": []}], "preferred_name": "TE06", "taxa": []}
{"type": "biolink:Cell", "ic": 53.04539250746212, "identifiers": [{"i": "CL:0000723", "l": "somatic stem cell", "d": ["A stem cell that can give rise to cell types of the body other than those of the germ-line."], "t": []}, {"i": "UMLS:C1171322", "l": "Adult Stem Cells", "d": [], "t": []}, {"i": "NCIT:C43420", "l": "Adult Stem Cell", "d": ["Mostly multipotent undifferentiated stem cells found in a specific tissue admixed with differentiated cells."], "t": []}, {"i": "MESH:D053687", "l": "Adult Stem Cells", "d": [], "t": []}, {"i": "SNOMEDCT:417904004", "l": "", "d": [], "t": []}], "preferred_name": "somatic stem cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0684127", "l": "stage II megakaryocyte", "d": [], "t": []}], "preferred_name": "stage II megakaryocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5855324", "l": "Evruleucel", "d": [], "t": []}, {"i": "NCIT:C199046", "l": "Evruleucel", "d": [], "t": []}], "preferred_name": "Evruleucel", "taxa": []}
{"type": "biolink:Cell", "ic": 70.66959805369461, "identifiers": [{"i": "CL:0000152", "l": "exocrine cell", "d": ["A cell of an exocrine gland; i.e. a gland that discharges its secretion via a duct."], "t": []}, {"i": "UMLS:C0734999", "l": "Exocrine cell", "d": [], "t": []}], "preferred_name": "exocrine cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5978037", "l": "CD3 cells | Blood product unit | Hematopoietic progenitor cells | Cell markers", "d": [], "t": []}], "preferred_name": "CD3 cells | Blood product unit | Hematopoietic progenitor cells | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": 92.76600187037766, "identifiers": [{"i": "CL:0002166", "l": "epithelial cell of Malassez", "d": ["An epithelial cell that remains from the disintegration of the epithelial root sheath involved in the development of teeth."], "t": []}, {"i": "UMLS:C1179491", "l": "Epithelial cell of Malassez", "d": [], "t": []}], "preferred_name": "epithelial cell of Malassez", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5962497", "l": "Autologous Anti-IL-1RAP CAR T-cells CCTx-001", "d": [], "t": []}, {"i": "NCIT:C209763", "l": "Autologous Anti-IL-1RAP CAR T-cells CCTx-001", "d": ["A preparation of autologous CD4+ and CD8+ T-lymphocytes that have been transduced to express a chimeric antigen receptor (CAR) consisting of an anti-interleukin-1 receptor accessory protein (IL-1RAP; IL-1 receptor 3; IL-1R3) single chain variable fragment (scFv) coupled to the hinge domain of human immunoglobulin G1 (IgG1), the co-stimulatory signaling domain CD28, the signaling domain of 4-1BB (CD137), and the zeta chain of the T-cell receptor (TCR)/CD3 complex (CD3zeta), with potential immunostimulating and antineoplastic activities. Upon administration, autologous anti-IL-1RAP CAR T-cells CCTx-001 specifically recognize and kill IL-1RAP-expressing tumor cells. IL-1RAP, a transmembrane glycoprotein, is highly expressed on leukemic cells but not on healthy hematopoietic stem and progenitor cells (HSPCs); its expression has been correlated with poor prognosis."], "t": []}], "preferred_name": "Autologous Anti-IL-1RAP CAR T-cells CCTx-001", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4033143", "l": "submandibular ganglion nNOS neuron", "d": ["A parasympathetic neuron that has the soma located in the submandibular ganglion and expresses the marker neuronal nitric oxide synthase 1 (nNOS)."], "t": []}], "preferred_name": "submandibular ganglion nNOS neuron", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C6021789", "l": "Clue cells|PrThr|Sys:ANYGU", "d": [], "t": []}], "preferred_name": "Clue cells|PrThr|Sys:ANYGU", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4740204", "l": "Cells.CD4+2H4", "d": [], "t": []}], "preferred_name": "Cells.CD4+2H4", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5814740", "l": "OMIDUBICEL NON-CULTURED FRACTION", "d": [], "t": []}], "preferred_name": "OMIDUBICEL NON-CULTURED FRACTION", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4052033", "l": "biliary tuft cell", "d": ["A tuft cell that is part of the extrahepatic biliary tree, including the gallbladder and extrahepatic bile ducts. It shares a core genetic program with intestinal tuft cells but has unique tissue-specific genes. Biliary tuft cell functions as a bile acid-sensitive regulator, suppressing inflammation and modulating microbiome-dependent neutrophil infiltration in biliary tissues. Unlike its intestinal counterparts, this cell decreases in number postnatally as bile acid production matures, with its abundance negatively regulated by bile acids."], "t": []}], "preferred_name": "biliary tuft cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1709635", "l": "Precursor Adenohypophysial Cell", "d": [], "t": []}, {"i": "NCIT:C45957", "l": "Precursor Adenohypophysial Cell", "d": [], "t": []}], "preferred_name": "Precursor Adenohypophysial Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C3641631", "l": "FAP-specific CD8-positive T Cells", "d": [], "t": []}, {"i": "NCIT:C103829", "l": "FAP-specific CD8-positive T Cells", "d": ["A preparation of CD8-positive T cells specific for human fibroblast activating protein (FAP) with potential immunopotentiating activity. T cells have been genetically modified to express a chimeric antigen receptor specific for FAP. Upon infusion, the FAP-specific CD8-positive T cells bind to FAP-expressing tumor cells and exhibit a selective toxicity to tumor cells. This may result in both tumor cell lysis and inhibition of tumor cell growth. FAP, a cell surface glycoprotein, is overexpressed on tumor-associated fibroblasts but minimally expressed on normal, healthy cells."], "t": []}], "preferred_name": "FAP-specific CD8-positive T Cells", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4023114", "l": "calyx vestibular afferent neuron", "d": ["A vestibular afferent neuron which posseses a unique postsynaptic terminal, the calyx, which completely covers the basolateral walls of type I hair cells and receives input from multiple ribbon synapses."], "t": []}], "preferred_name": "calyx vestibular afferent neuron", "taxa": []}
{"type": "biolink:Cell", "ic": 88.20185721311867, "identifiers": [{"i": "CL:0004115", "l": "retinal ganglion cell B", "d": ["A monostratified retinal ganglion cell with small to medium soma and small to medium dendritic field."], "t": []}], "preferred_name": "retinal ganglion cell B", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5172506", "l": "Mesothelial cells | Peritoneal fluid | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Mesothelial cells | Peritoneal fluid | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0002460", "l": "CD8-alpha-negative thymic conventional dendritic cell", "d": ["A conventional thymic dendritic cell that is CD8-alpha-negative."], "t": []}], "preferred_name": "CD8-alpha-negative thymic conventional dendritic cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5157335", "l": "CD16-CD57+ | White blood cells | Cell markers", "d": [], "t": []}], "preferred_name": "CD16-CD57+ | White blood cells | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5447838", "l": "Allogeneic Anti-CD19-CAR-CD28-IL-15-expressing Natural Killer T-cells", "d": [], "t": []}, {"i": "NCIT:C177533", "l": "Allogeneic Anti-CD19-CAR-CD28-IL-15-expressing Natural Killer T-cells", "d": ["A preparation of allogeneic natural killer T-lymphocytes (NKTs) that have been engineered to express a chimeric antigen receptor (CAR) specific for the human tumor associated antigen (TAA) CD19, interleukin 15 (IL-15) and the costimulatory T-cell-specific surface glycoprotein CD28, with potential immunostimulating and antineoplastic activities. Upon administration, allogeneic anti-CD19-CAR-CD28-IL-15-expressing NKTs target, bind to, and induce selective toxicity in CD19-expressing tumor cells. IL-15 is a pro-survival cytokine that promotes T-cell persistence and potentiates the immune response against tumor cells. CD28 costimulatory molecule enhances activation and signaling after recognition of CD19, and may increase proliferation of T-cells and antitumor activity. CD19 antigen is a B-cell specific cell surface antigen overexpressed in B-cell lineage malignancies."], "t": []}], "preferred_name": "Allogeneic Anti-CD19-CAR-CD28-IL-15-expressing Natural Killer T-cells", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0004221", "l": "flag A amacrine cell", "d": ["A flag amacrine cell with post-synaptic terminals in S2 and S3. This cell type releases the neurotransmitter glycine."], "t": []}], "preferred_name": "flag A amacrine cell", "taxa": []}
{"type": "biolink:Cell", "ic": 92.76600187037766, "identifiers": [{"i": "CL:0000981", "l": "double negative memory B cell", "d": ["A memory B cell with the phenotype IgD-negative and CD27-negative."], "t": []}], "preferred_name": "double negative memory B cell", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "CL:2000011", "l": "dermis lymphatic vessel endothelial cell", "d": ["Any endothelial cell of lymphatic vessel that is part of a dermis."], "t": []}], "preferred_name": "dermis lymphatic vessel endothelial cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4484161", "l": "Cells.Ki-67 nuclear", "d": [], "t": []}], "preferred_name": "Cells.Ki-67 nuclear", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "UMLS:C1513410", "l": "Monkey Cell Line", "d": [], "t": []}, {"i": "NCIT:C20219", "l": "Monkey Cell Line", "d": [], "t": []}], "preferred_name": "Monkey Cell Line", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0002238", "l": "male gonocyte", "d": ["A primordial germ cell that is destined to become a male germ cell."], "t": []}, {"i": "UMLS:C0683194", "l": "Male gonocyte", "d": [], "t": []}], "preferred_name": "male gonocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 83.11065783093733, "identifiers": [{"i": "UMLS:C5237484", "l": "Anti-B7-H3 CAR T Cells Preparation", "d": [], "t": []}, {"i": "NCIT:C165844", "l": "Anti-B7-H3 CAR T-cells", "d": ["A preparation of T-lymphocytes that have been genetically modified to express a chimeric antigen receptor (CAR) targeting the immunoregulatory protein B7-homologue 3 (B7-H3, CD276) and containing, as of yet undisclosed co-stimulatory signaling domains, with potential immunostimulating and antineoplastic activities. Upon administration, anti-B7-H3 CAR T-cells target and bind to B7-H3-expressing tumor cells, thereby inducing selective toxicity in B7-H3-expressing tumor cells. B7-H3, a type I transmembrane protein and a member of the B7 co-stimulatory protein superfamily, is overexpressed on certain tumor cell types and on various immune cells. It is a negative regulator of T-cell activation and its overexpression plays a key role in tumor cell invasion and metastasis."], "t": []}, {"i": "NCIT:C201492", "l": "Anti-B7-H3 CAR T Cells Preparation", "d": ["Any preparation of chimeric antigen receptor (CAR) expressing T-lymphocytes that targets the tumor-associated antigen (TAA) B7-H3 (CD276)."], "t": []}], "preferred_name": "Anti-B7-H3 CAR T Cells Preparation", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C2984201", "l": "Leukemic Apoptotic Corpse-Pulsed Autologous Dendritic Cells", "d": [], "t": []}, {"i": "NCIT:C91379", "l": "Leukemic Apoptotic Corpse-Pulsed Autologous Dendritic Cells", "d": ["A cell-based cancer vaccine composed of autologous dendritic cells (DCs) pulsed with corpses of apoptotic leukemic cells, with potential immunostimulatory and antineoplastic activities. Upon vaccination, autologous dendritic cells pulsed with leukemic apoptotic corpse may activate the immune system to mount an anti-tumoral cytotoxic T-lymphocyte (CTL) response against leukemic cells expressing leukemia-associated antigens, which may result in leukemic cell lysis and inhibition of tumor cell growth. Apoptotic tumor cell corpses contain an array of tumor associated antigens (TAAs)."], "t": []}], "preferred_name": "Leukemic Apoptotic Corpse-Pulsed Autologous Dendritic Cells", "taxa": []}
{"type": "biolink:Cell", "ic": 83.63771255585968, "identifiers": [{"i": "CL:1000279", "l": "smooth muscle cell of large intestine", "d": ["A smooth muscle cell that is part of the large intestine."], "t": []}, {"i": "UMLS:C0734774", "l": "Smooth muscle fiber of large intestine", "d": [], "t": []}], "preferred_name": "smooth muscle cell of large intestine", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5666913", "l": "Autologous Anti-FLT3 CAR T Cells TAA05", "d": [], "t": []}, {"i": "NCIT:C183535", "l": "Autologous Anti-FLT3 CAR T Cells TAA05", "d": ["A preparation of autologous T-lymphocytes genetically engineered with a chimeric antigen receptor (CAR) specific for the tumor-associated antigen FMS-like tyrosine kinase 3 (FLT3; CD135; STK1; FLK2), with potential immunostimulating and antineoplastic activities. Upon administration, the autologous anti-FLT3 CAR T cells TAA05 target and bind to tumor cells expressing FLT3, which results in the cytotoxic T-lymphocyte (CTL)-mediated cell killing of FLT3-expressing tumor cells. FLT3, a class III receptor tyrosine kinase (RTK), is overexpressed or mutated in most B-lineage neoplasms and in acute myeloid leukemias (AMLs)."], "t": []}], "preferred_name": "Autologous Anti-FLT3 CAR T Cells TAA05", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0020041", "l": "oRGC4", "d": ["A conserved retinal ganglion cell orthotype whose transcriptomic profile groups together ON midget RGCs from primate foveal and peripheral retina with their molecularly homologous mouse alpha RGC subtype (ON-sustained α RGC, C43) (Hahn et al., 2023; Tran et al., 2019). Reference to the transcriptomic evidence is found at: GSE237215."], "t": []}], "preferred_name": "oRGC4", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5216270", "l": "Monocytes.abnormal|NCnc|Pt|Bld", "d": [], "t": []}], "preferred_name": "Monocytes.abnormal|NCnc|Pt|Bld", "taxa": []}
{"type": "biolink:Cell", "ic": 83.63771255585968, "identifiers": [{"i": "CL:0000975", "l": "short lived plasma cell", "d": ["A fully differentiated plasma cell that lives for months."], "t": []}], "preferred_name": "short lived plasma cell", "taxa": []}
{"type": "biolink:Cell", "ic": 88.20185721311867, "identifiers": [{"i": "UMLS:C1512105", "l": "Dysplastic Granulocyte", "d": [], "t": []}, {"i": "NCIT:C37051", "l": "Dysplastic Granulocyte", "d": [], "t": []}], "preferred_name": "Dysplastic Granulocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 89.40238429118027, "identifiers": [{"i": "CL:0002058", "l": "Gr1-low non-classical monocyte", "d": ["A resident monocyte that is Gr-1 low, CD43-positive, and CX3CR1-positive."], "t": []}], "preferred_name": "Gr1-low non-classical monocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5785510", "l": "Reprogrammed Cell Specimen", "d": [], "t": []}, {"i": "NCIT:C193000", "l": "Reprogrammed Cell Specimen", "d": ["A biospecimen consisting of cells that began as specialized cells but were transformed such that they are in an unspecialized state or have acquired different specialized characteristics."], "t": []}], "preferred_name": "Reprogrammed Cell Specimen", "taxa": []}
{"type": "biolink:Cell", "ic": 89.40238429118027, "identifiers": [{"i": "CL:0000564", "l": "neutrophilic promyelocyte", "d": ["A promyelocyte committed to the neutrophil lineage. This cell type is GATA-1-positive, C/EBPa-positive, AML-1-positive, MPO-positive, has low expression of PU.1 transcription factor and lacks lactotransferrin expression."], "t": []}], "preferred_name": "neutrophilic promyelocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 90.871710685482, "identifiers": [{"i": "CL:0015000", "l": "cranial motor neuron", "d": ["Motor neuron that innervate muscles that control eye, jaw, and facial movements of the vertebrate head and parasympathetic neurons that innervate certain glands and organs."], "t": []}], "preferred_name": "cranial motor neuron", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C2709135", "l": "Frozen erythrocytes pediatric units", "d": [], "t": []}], "preferred_name": "Frozen erythrocytes pediatric units", "taxa": []}
{"type": "biolink:Cell", "ic": 69.80950740566307, "identifiers": [{"i": "CL:0000894", "l": "DN1 thymic pro-T cell", "d": ["A pro-T cell that has the phenotype CD4-negative, CD8-negative, CD44-positive, and CD25-negative."], "t": []}], "preferred_name": "DN1 thymic pro-T cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1440373", "l": "CD97+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:1372946007", "l": "", "d": [], "t": []}], "preferred_name": "CD97+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": 92.76600187037766, "identifiers": [{"i": "CL:0001010", "l": "mature dermal dendritic cell", "d": ["Mature dermal dendritic cell is a dermal dendritic cell that is CD80-high, CD86-high, MHCII-high and is CD83-positive."], "t": []}], "preferred_name": "mature dermal dendritic cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C6052664", "l": "Autologous Anti-CCR4 CAR-4-1BB-CD3zeta-expressing T-cells", "d": [], "t": []}, {"i": "NCIT:C219649", "l": "Autologous Anti-CCR4 CAR-4-1BB-CD3zeta-expressing T-cells", "d": ["A preparation of autologous T-lymphocytes that have been transduced with a lentiviral vector to express a chimeric antigen receptor (CAR) targeting C-C chemokine receptor 4 (CCR4) and linked to the intracellular signaling domains of 4-1BB (CD137) and the zeta chain of the TCR/CD3 complex (TCRzeta; CD247; CD3zeta), with potential immunomodulating and antineoplastic activities. Upon administration, the autologous anti-CCR4 CAR-4-1BB-CD3zeta-expressing T-cells target, bind to and induce selective toxicity in CCR4-expressing tumor cells. CCR4 is a chemokine receptor overexpressed on certain cancer cell types including adult T-cell lymphoma (ATL) and peripheral T-cell lymphoma (PTCL)."], "t": []}], "preferred_name": "Autologous Anti-CCR4 CAR-4-1BB-CD3zeta-expressing T-cells", "taxa": []}
{"type": "biolink:Cell", "ic": 83.11065783093733, "identifiers": [{"i": "CL:0002001", "l": "CD34-positive, CD38-positive granulocyte monocyte progenitor", "d": ["A granulocyte monocyte progenitor is CD34-positive, CD38-positive, IL-3receptor-alpha-positive and is CD45RA-negative."], "t": []}], "preferred_name": "CD34-positive, CD38-positive granulocyte monocyte progenitor", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0221279", "l": "Burr cell", "d": [], "t": []}, {"i": "SNOMEDCT:51384001", "l": "", "d": [], "t": []}], "preferred_name": "Burr cell", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "CL:0002054", "l": "fraction E immature B cell", "d": ["An immature B cell that is IgM-positive, CD45R-positive, CD43-low, CD25-negative, and CD127-negative. This cell type has also been described as being AA4-positive, IgM-positive, CD19-positive, CD43-low/negative, and HSA-positive."], "t": []}], "preferred_name": "fraction E immature B cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5571714", "l": "Transitional cells.superficial|Urine/Urine sed", "d": [], "t": []}], "preferred_name": "Transitional cells.superficial|Urine/Urine sed", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5175145", "l": "Nucleated cells | Blood | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Nucleated cells | Blood | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5854439", "l": "Allogeneic Anti-CD33 CAR-NK Cells QN-023a", "d": [], "t": []}, {"i": "NCIT:C199622", "l": "Allogeneic Anti-CD33 CAR-NK Cells QN-023a", "d": ["A preparation of off-the-shelf (OTS), allogeneic natural killer (NK) cells, derived from genetically engineered human induced pluripotent stem cells (iPSCs), that are genetically engineered to express a chimeric antigen receptor (CAR) specific for the tumor-associated antigen (TAA) cluster of differentiation 33 (CD33), and containing a high-affinity, non-cleavable CD16 (hnCD16) to enhance antibody-dependent cell-mediated cytotoxicity (ADCC), an interleukin-15 (IL-15) molecule to increase the persistence of allogeneic cells in vivo, and a CD38 knockout to avoid depletion of CAR-NK cells, with potential immunomodulating and antineoplastic activities. Upon administration, the allogeneic anti-CD33 CAR-NK cells QN-023a recognize, bind to and induce selective cytotoxicity in CD33-expressing tumor cells. CD33 is expressed on normal non-pluripotent hematopoietic stem cells and on myeloid leukemia cells."], "t": []}], "preferred_name": "Allogeneic Anti-CD33 CAR-NK Cells QN-023a", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5554955", "l": "Autologous Natural Killer Cells SNK01", "d": [], "t": []}, {"i": "NCIT:C178330", "l": "Autologous Natural Killer Cells SNK01", "d": ["A preparation of autologous, ex-vivo expanded and activated natural killer (NK) cells, with potential cytolytic and antineoplastic activities. Upon infusion back into the patient, the autologous NK cells SNK01 may lyse cancer cells. These cells also secrete pro-inflammatory cytokines, which further stimulate an anti-tumor immune response."], "t": []}], "preferred_name": "Autologous Natural Killer Cells SNK01", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1317190", "l": "CD2+CD7+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:1372991003", "l": "", "d": [], "t": []}], "preferred_name": "CD2+CD7+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": 67.05067056748027, "identifiers": [{"i": "UMLS:C0682523", "l": "Human Cell Line", "d": [], "t": []}, {"i": "NCIT:C20218", "l": "Human Cell Line", "d": [], "t": []}], "preferred_name": "Human Cell Line", "taxa": []}
{"type": "biolink:Cell", "ic": 77.38833137893549, "identifiers": [{"i": "UMLS:C1513755", "l": "Multivacuolated Lipoblast", "d": [], "t": []}, {"i": "NCIT:C36973", "l": "Multivacuolated Lipoblast", "d": [], "t": []}], "preferred_name": "Multivacuolated Lipoblast", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4033031", "l": "diffuse bipolar 4 cell", "d": ["An ON diffuse bipolar cell that predominantly connects to ON parasol cells and lateral amacrine cells."], "t": []}], "preferred_name": "diffuse bipolar 4 cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4239859", "l": "Vascular smooth muscle cell of arch of aorta", "d": [], "t": []}], "preferred_name": "Vascular smooth muscle cell of arch of aorta", "taxa": []}
{"type": "biolink:Cell", "ic": 38.13489571127312, "identifiers": [{"i": "CL:0000133", "l": "neurectodermal cell", "d": ["Ectoderm destined to be nervous tissue."], "t": []}], "preferred_name": "neurectodermal cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1370155", "l": "Lymphocytes+Monocytes", "d": [], "t": []}], "preferred_name": "Lymphocytes+Monocytes", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0003028", "l": "M1 retinal ganglion cell", "d": ["A monostratified retinal ganglion cell that has a small dendrite field with a dense dendrite arbor with post synaptic terminals in sublaminer layer S4."], "t": []}], "preferred_name": "M1 retinal ganglion cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C2325214", "l": "Submandibular ganglion neuron", "d": [], "t": []}], "preferred_name": "Submandibular ganglion neuron", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C3826997", "l": "Carboxylesterase-expressing Allogeneic Neural Stem Cells", "d": [], "t": []}, {"i": "NCIT:C113657", "l": "Carboxylesterase-expressing Allogeneic Neural Stem Cells", "d": ["A preparation of allogeneic neural stem cells (NSC), derived from a human fetal cell line, that are adenovirally-transduced to express a modified form of the human enzyme carboxylesterase (CE) hCE1m6, with potential adjuvant activity. Upon intracranial administration, NSCs localize to tumor sites, due to their tumor-trophic nature, and transiently express hCE1m6. Intravenous co-administration of the prodrug irinotecan allows for the selective conversion by hCE1m6 to its active metabolite and topoisomerase I inhibitor, SN-38, in the vicinity of tumor sites. This leads to a local anti-neoplastic effect and causes reduced toxicity and increased therapeutic efficacy of irinotecan. Since NSCs freely cross the blood-brain barrier, these cells can also be intravenously administered to target brain tumor cells. hCE1m6 shows increased activity as compared to unmodified human CE."], "t": []}], "preferred_name": "Carboxylesterase-expressing Allogeneic Neural Stem Cells", "taxa": []}
{"type": "biolink:Cell", "ic": 89.40238429118027, "identifiers": [{"i": "CL:1000223", "l": "pulmonary neuroendocrine cell", "d": ["A neuroendocrine cell that is part of respiratory epithelium of the lung and is involved in the sensory detection of environmental stimuli, including hypoxia, nicotine and air pressure. Ultrastructurally, this cell type is characterized by the presence of cytoplasmic dense core granules, which are considered the storage sites of amine and peptide hormones. Pulmonary neuroendocrine cells are innervated and appear as solitary cells or as clustered masses, localized at airway bifurcation sites, called neuroepithelial bodies that can release serotonin in response to hypoxia and interact with sensory nerve terminals. Pulmonary neuroendocrine cells also function as reserve stem cells that repair the surrounding epithelium after injury."], "t": []}], "preferred_name": "pulmonary neuroendocrine cell", "taxa": []}
{"type": "biolink:Cell", "ic": 65.24536274840406, "identifiers": [{"i": "CL:0002159", "l": "general ecto-epithelial cell", "d": ["Epithelial cells derived from general body ectoderm and ectoderm placodes."], "t": []}, {"i": "UMLS:C1182615", "l": "General ecto-epithelial cell", "d": [], "t": []}], "preferred_name": "general ecto-epithelial cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4023081", "l": "inverted L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (Mmus)", "d": ["a L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex that has inverted pyramidal morphology."], "t": []}], "preferred_name": "inverted L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (Mmus)", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1179009", "l": "Retinal pigment cell", "d": [], "t": []}], "preferred_name": "Retinal pigment cell", "taxa": []}
{"type": "biolink:Cell", "ic": 92.76600187037766, "identifiers": [{"i": "CL:0002118", "l": "CD38-negative IgG-negative class switched memory B cell", "d": ["A CD38-negative IgG-negative memory B cell is a IgG-negative class switched memory B cell that lacks IgG on the cell surface with the phenotype CD38-negative and IgG-negative."], "t": []}], "preferred_name": "CD38-negative IgG-negative class switched memory B cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5203928", "l": "Autologous HER2-CAR-modified Adenovirus-specific Cytotoxic T-lymphocytes", "d": [], "t": []}, {"i": "NCIT:C158744", "l": "Autologous HER2-CAR-modified Adenovirus-specific Cytotoxic T-lymphocytes", "d": ["A population of autologous cytotoxic T-lymphocytes (CTLs) specifically reactive to human adenovirus (Ad) that have been transduced with a retroviral vector expressing a second-generation human epidermal growth factor receptor type 2 (HER2; EGFR2; ErbB2)-specific chimeric antigen receptor (CAR) comprised of an exodomain based on a anti-CD22 single chain variable fragment (scFv) from the anti-HER2 monoclonal antibody FRP5 that is linked to the costimulatory domains of CD28 and the zeta chain of the TCR/CD3 complex (CD3zeta), with potential immunostimulating and antineoplastic activities. Upon intravenous administration, the autologous HER2-CAR-modified Ad-specific CTLs are directed to and induce selective toxicity in HER2-expressing tumor cells. Additionally, these cells may help reconstitute Ad-specific CTL responses in immunocompromised individuals and others at risk of developing Ad-infection. HER2, a receptor tyrosine kinase (RTK) overexpressed by a variety of tumor cell types, belongs to the EGFR superfamily and plays a key role in tumor cell proliferation."], "t": []}], "preferred_name": "Autologous HER2-CAR-modified Adenovirus-specific Cytotoxic T-lymphocytes", "taxa": []}
{"type": "biolink:Cell", "ic": 90.871710685482, "identifiers": [{"i": "CL:1000082", "l": "stretch receptor cell", "d": [], "t": []}], "preferred_name": "stretch receptor cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5783387", "l": "Motacabtagene Lurevgedleucel", "d": [], "t": []}], "preferred_name": "Motacabtagene Lurevgedleucel", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4310109", "l": "SN-VTR CALB1 Dopa substantia nigra dopaminergic neuron (Primate)", "d": ["A substantia nigra dopaminergic neuron of the Primates brain. These cells are located in the substantia nigra . Reference transcriptomic data for this type can be found in the dataset/taxonomy - HMBA Basal Ganglia Consensus Taxonomy in cell set Group:SN-VTR CALB1 Dopa."], "t": []}], "preferred_name": "SN-VTR CALB1 Dopa substantia nigra dopaminergic neuron (Primate)", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0007023", "l": "flask cell", "d": ["Epidermal cell rich in mitochondria. In amphibians, appears during metamorphosis."], "t": []}], "preferred_name": "flask cell", "taxa": []}
{"type": "biolink:Cell", "ic": 89.40238429118027, "identifiers": [{"i": "CL:0000326", "l": "glycogen accumulating cell", "d": [], "t": []}], "preferred_name": "glycogen accumulating cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:1001005", "l": "glomerular capillary endothelial cell", "d": ["An endothelial cell that is part of the glomerular capillary of the kidney."], "t": []}], "preferred_name": "glomerular capillary endothelial cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0002644", "l": "endo-epithelial cell of tympanic part of viscerocranial mucosa", "d": ["An endothelial cell of viscerocranial mucosa that is part of the tympanic region of the viscerocranial mucosa."], "t": []}, {"i": "UMLS:C1182667", "l": "Endo-epithelial cell of tympanic part of viscerocranial mucosa", "d": [], "t": []}], "preferred_name": "endo-epithelial cell of tympanic part of viscerocranial mucosa", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5983692", "l": "Negatively-selected Cell Sample", "d": [], "t": []}, {"i": "NCIT:C211925", "l": "Negatively-selected Cell Sample", "d": ["A cell sample that has had at least one type of cell removed."], "t": []}], "preferred_name": "Negatively-selected Cell Sample", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4072046", "l": "pvalb chandelier GABAergic interneuron (Homo sapiens)", "d": ["A transcriptomically definined GABAergic interneuron of the human pallium.  These cells correspond to the classically defined pvalb chandelier neuron type. The standard transcriptomic reference data for this cell type can be found on the CellxGene census under the collection: 'Transcriptomic cytoarchitecture reveals principles of human neocortex organization', dataset: 'Supercluster: CGE-derived interneurons', Author Categories: 'CrossArea_subclass', clusters Chandelier."], "t": []}], "preferred_name": "pvalb chandelier GABAergic interneuron (Homo sapiens)", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0000410", "l": "CNS long range interneuron", "d": [], "t": []}], "preferred_name": "CNS long range interneuron", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C6021981", "l": "Leukocytes | Aspirate | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Leukocytes | Aspirate | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5237723", "l": "Engineered Mobilized Peripheral Blood-derived Donor Graft OGFT-001", "d": [], "t": []}, {"i": "NCIT:C166136", "l": "Engineered Mobilized Peripheral Blood-derived Donor Graft OGFT-001", "d": ["An engineered donor graft derived from mobilized peripheral blood stem cells (PBSCs) that can potentially be used for immune reconstitution purposes. Upon administration of the engineered mobilized peripheral blood-derived donor graft OGFT-001 after an allogeneic hematopoietic cell transplantation, these cells provide hematopoietic cell recovery."], "t": []}], "preferred_name": "Engineered Mobilized Peripheral Blood-derived Donor Graft OGFT-001", "taxa": []}
{"type": "biolink:Cell", "ic": 92.76600187037766, "identifiers": [{"i": "CL:0000991", "l": "CD11c-negative plasmacytoid dendritic cell", "d": ["CD11c-negative plasmacytoid dendritic cell is a leukocyte is CD11c-negative, CD45RA-positive, CD85g-positive(ILT7), CD123-positive, CD303-positive."], "t": []}], "preferred_name": "CD11c-negative plasmacytoid dendritic cell", "taxa": []}
{"type": "biolink:Cell", "ic": 76.22330125402472, "identifiers": [{"i": "UMLS:C1522040", "l": "Signet Ring Adenocarcinoma Cell", "d": [], "t": []}, {"i": "NCIT:C36777", "l": "Signet Ring Adenocarcinoma Cell", "d": ["A malignant glandular cell containing cytoplasmic mucin. The presence of mucin pushes the nucleus of the cell to the periphery, assuming a configuration resembling a signet ring."], "t": []}], "preferred_name": "Signet Ring Adenocarcinoma Cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0545589", "l": "Blood monocytic cell", "d": [], "t": []}], "preferred_name": "Blood monocytic cell", "taxa": []}
{"type": "biolink:Cell", "ic": 92.76600187037766, "identifiers": [{"i": "UMLS:C1519715", "l": "Type II Epithelial Receptor Cell", "d": [], "t": []}, {"i": "NCIT:C33825", "l": "Type II Epithelial Receptor Cell", "d": ["A light cell found in taste buds that has large amorphous areas of cytoplasmic matrix, scarce ribosomes and RER. Most are alpha-gustducin immunoreactive, some may be AbH immunoreactive and/or PGP 9.5 immunoreactive."], "t": []}], "preferred_name": "Type II Epithelial Receptor Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4052008", "l": "crypt-bottom fibroblast", "d": ["A subepithelial intestinal fibroblast that is located adjacent to the base of the crypt of Lieberkühn, near the intestinal stem cells. Characterized by low PDGFRα expression, this cell is crucial for maintaining the intestinal stem cell niche. Crypt-bottom fibroblast secretes key signaling molecules including canonical Wnt ligands (Wnt2, Wnt2b), Wnt potentiators (Rspo3), and BMP inhibitors (Grem1), which collectively regulate intestinal stem cell function and epithelial homeostasis."], "t": []}], "preferred_name": "crypt-bottom fibroblast", "taxa": []}
{"type": "biolink:Cell", "ic": 92.76600187037766, "identifiers": [{"i": "CL:0000024", "l": "oogonial cell", "d": ["An undifferentiated germ cell that proliferates rapidly and gives rise to oocytes."], "t": []}, {"i": "UMLS:C4277534", "l": "Oogonial Stem Cells", "d": [], "t": []}, {"i": "MESH:D000072977", "l": "Oogonial Stem Cells", "d": [], "t": []}], "preferred_name": "oogonial cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0000142", "l": "hyalocyte", "d": ["A cell occurring in the peripheral part of the vitreous body of the eye that may be responsible for production of hyaluronic acid and collagen."], "t": []}, {"i": "UMLS:C1182659", "l": "Hyalocyte", "d": [], "t": []}], "preferred_name": "hyalocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 71.31251504405601, "identifiers": [{"i": "CL:0000808", "l": "DN4 thymocyte", "d": ["A thymocyte that has the phenotype CD4-negative, CD8-negative, CD44-negative, CD25-negative, and pre-TCR-positive."], "t": []}], "preferred_name": "DN4 thymocyte", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1267932", "l": "Lymphocyte positive for CD45RO antigen", "d": [], "t": []}, {"i": "SNOMEDCT:117375005", "l": "", "d": [], "t": []}], "preferred_name": "Lymphocyte positive for CD45RO antigen", "taxa": []}
{"type": "biolink:Cell", "ic": 79.35380886648232, "identifiers": [{"i": "CL:0002625", "l": "seminiferous tubule epithelial cell", "d": ["A cell of the seminiferous tubule epithelium."], "t": []}], "preferred_name": "seminiferous tubule epithelial cell", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "CL:0002150", "l": "epithelioid macrophage", "d": ["Epithelioid macrophage is an activated macrophage that resembles an epithelial cell with finely granular, pale eosinophilic cytoplasm and central, ovoid nucleus (oval or elongate). This cell type is able to merge into one another to form aggregates. The presence of such aggregates may characterize some pathologic conditions, mainly granulomatous inflammation."], "t": []}, {"i": "UMLS:C0014603", "l": "Epithelioid Cells", "d": [], "t": []}, {"i": "NCIT:C12559", "l": "Epithelioid Cell", "d": ["A cell of mononuclear phagocyte system origin that resembles an epithelial cell and is involved in immune granuloma formation."], "t": []}, {"i": "MESH:D015622", "l": "Epithelioid Cells", "d": [], "t": []}], "preferred_name": "epithelioid macrophage", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0020065", "l": "ionocyte of salivary gland", "d": ["An ionocyte that is part of a salivary gland, localized to the ductal compartment on the luminal side. This specialized epithelial cell is characterized by expression of FOXI1 and is involved in regulating and maintaining osmotic pressure within the glandular environment (Dong et al., 2024). In normal human salivary glands, FOXI1-positive cells constitute less than 5% of ductal epithelial cells and are found exclusively in ducts, never in acini, across all major gland types including parotid, submandibular, sublingual, and minor salivary glands (Hoki et al., 2024). Like ionocytes in other tissues, this cell is expected to express high levels of CFTR and possess abundant mitochondria and ion transporters."], "t": []}], "preferred_name": "ionocyte of salivary gland", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:1000470", "l": "myoepithelial cell of primary lactiferous duct", "d": ["A myoepithelial cell that is part of the primary lactiferous duct."], "t": []}, {"i": "UMLS:C1184138", "l": "Myoepithelial cell of primary lactiferous duct", "d": [], "t": []}], "preferred_name": "myoepithelial cell of primary lactiferous duct", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4052062", "l": "onychofibroblast", "d": ["A specialized fibroblast located in the onychodermis that play a key role in nail growth and regeneration by interacting with LGR6-positive nail matrix keratinocytes. These interactions mediate essential signaling pathways, particularly WNT signaling, which is critical for epithelial–mesenchymal communication and coordinated nail development. In humans, this cell expresses key markers, including RSPO4, MSX1, WIF1, and BMP5, all involved in nail differentiation."], "t": []}], "preferred_name": "onychofibroblast", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5985524", "l": "Autologous Anti-CD83 CAR T-cells", "d": [], "t": []}, {"i": "NCIT:C214495", "l": "Autologous Anti-CD83 CAR T-cells", "d": ["A preparation of autologous T-lymphocytes engineered to express a chimeric antigen receptor (CAR) targeting CD83, with potential antineoplastic activity. Upon administration, autologous anti-CD83 CAR T-cells recognize and kill CD83-expressing tumor cells. CD83 is expressed on acute myeloid leukemia (AML) blasts."], "t": []}], "preferred_name": "Autologous Anti-CD83 CAR T-cells", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0333742", "l": "Syncytial cell", "d": [], "t": []}, {"i": "SNOMEDCT:72263005", "l": "", "d": [], "t": []}], "preferred_name": "Syncytial cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5909016", "l": "Solizmestrocel", "d": [], "t": []}, {"i": "NCIT:C203133", "l": "Solizmestrocel", "d": [], "t": []}], "preferred_name": "Solizmestrocel", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C6063210", "l": "CD1c+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:1372861009", "l": "", "d": [], "t": []}], "preferred_name": "CD1c+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0002414", "l": "immature Vgamma1.1-positive, Vdelta6.3-negative thymocyte", "d": ["A Vgamma1.1-positive, Vdelta6.3-negative thymocyte that is CD24-positive."], "t": []}], "preferred_name": "immature Vgamma1.1-positive, Vdelta6.3-negative thymocyte", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1440282", "l": "CD3+CD4+CD45RA+CD45RO+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:1373249000", "l": "", "d": [], "t": []}], "preferred_name": "CD3+CD4+CD45RA+CD45RO+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1704617", "l": "Perivascular Epithelioid Cell", "d": [], "t": []}, {"i": "NCIT:C45634", "l": "Perivascular Epithelioid Cell", "d": ["A perivascular cell with abundant clear or eosinophilic cytoplasm that contains glycogen. -- 2005"], "t": []}], "preferred_name": "Perivascular Epithelioid Cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1545578", "l": "Neutrophils.hypogranulated", "d": [], "t": []}], "preferred_name": "Neutrophils.hypogranulated", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0009105", "l": "T cell zone reticular cell", "d": ["A fibroblastic reticular cell found in the lymph node T cell domain."], "t": []}], "preferred_name": "T cell zone reticular cell", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "UMLS:C1709771", "l": "Pulmonary Neuroendocrine Cell", "d": [], "t": []}, {"i": "NCIT:C45572", "l": "Pulmonary Neuroendocrine Cell", "d": [], "t": []}], "preferred_name": "Pulmonary Neuroendocrine Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 84.83823963392128, "identifiers": [{"i": "CL:0002165", "l": "phalangeal cell", "d": ["A supporting cell that is attached to the basement membrane and forms rows that support the hair cells."], "t": []}], "preferred_name": "phalangeal cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0682538", "l": "intact cell", "d": [], "t": []}], "preferred_name": "intact cell", "taxa": []}
{"type": "biolink:Cell", "ic": 83.11065783093733, "identifiers": [{"i": "CL:0000011", "l": "migratory trunk neural crest cell", "d": ["Cell that is part of the migratory trunk neural crest population. Migratory trunk neural crest cells develop from premigratory trunk neural crest cells and have undergone epithelial to mesenchymal transition and delamination."], "t": []}], "preferred_name": "migratory trunk neural crest cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1515146", "l": "TE03", "d": [], "t": []}, {"i": "NCIT:C20296", "l": "TE03", "d": ["Provider: Technion University, Haifa, Israel. No information from provider. This cell line meets the criteria for the use of human embryonic stem cells by federally funded researchers."], "t": []}], "preferred_name": "TE03", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C3658289", "l": "Human Induced Pluripotent Stem Cells", "d": [], "t": []}], "preferred_name": "Human Induced Pluripotent Stem Cells", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5419242", "l": "Tonogenconcel", "d": [], "t": []}, {"i": "NCIT:C171656", "l": "Tonogenconcel", "d": [], "t": []}], "preferred_name": "Tonogenconcel", "taxa": []}
{"type": "biolink:Cell", "ic": 92.76600187037766, "identifiers": [{"i": "CL:4023188", "l": "midget ganglion cell of retina", "d": ["A retinal ganglion cell that originate in the ganglion cell layer of the retina, and project to the parvocellular layers of the lateral geniculate nucleus (LGN). These cells are known as midget retinal ganglion cells due to the small sizes of their dendritic trees and cell bodies."], "t": []}, {"i": "UMLS:C2338777", "l": "Midget ganglion cell of retina", "d": [], "t": []}], "preferred_name": "midget ganglion cell of retina", "taxa": []}
{"type": "biolink:Cell", "ic": 78.80476858236055, "identifiers": [{"i": "CL:0000122", "l": "stellate neuron", "d": ["A neuron that has dendritic processes radiating from the cell body forming a star-like shape."], "t": []}], "preferred_name": "stellate neuron", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4033176", "l": "dorsal root ganglion CGRP neuron", "d": ["A sensory neuron that has the soma located in the dorsal root ganglion and expresses the marker calcitonin gene-related peptide (CGRP). This peptidergic nociceptor subpopulation is involved in neurogenic inflammation and pain signaling."], "t": []}], "preferred_name": "dorsal root ganglion CGRP neuron", "taxa": []}
{"type": "biolink:Cell", "ic": 79.9528279018387, "identifiers": [{"i": "UMLS:C1706981", "l": "Bone Marrow Stem Cell with Potential to Differentiate to Granulocytic Lineage", "d": [], "t": []}, {"i": "NCIT:C42716", "l": "Bone Marrow Stem Cell with Potential to Differentiate to Granulocytic Lineage", "d": ["A primitive, undifferentiated blood cell which can undergo division and give rise to white blood cells in the neutrophil, eosinophil or basophil lines."], "t": []}], "preferred_name": "Bone Marrow Stem Cell with Potential to Differentiate to Granulocytic Lineage", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0002022", "l": "Ly-76 high positive erythrocyte", "d": ["An enucleate erythrocyte that is Lyg-76-high."], "t": []}], "preferred_name": "Ly-76 high positive erythrocyte", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4733878", "l": "Keratinocytes (Human)", "d": [], "t": []}], "preferred_name": "Keratinocytes (Human)", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0002055", "l": "CD38-negative immature B cell", "d": ["An immature B cell that is CD38-negative, CD10-low, CD21-low, and CD22-high."], "t": []}], "preferred_name": "CD38-negative immature B cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1257741", "l": "BALB 3T3 Cells", "d": [], "t": []}, {"i": "MESH:D041702", "l": "BALB 3T3 Cells", "d": [], "t": []}], "preferred_name": "BALB 3T3 Cells", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:1000478", "l": "transitional myocyte of sinoatrial node", "d": ["A transitional myocyte that is part of the sinoatrial node."], "t": []}, {"i": "UMLS:C1179871", "l": "Myocyte of sinuatrial node", "d": [], "t": []}], "preferred_name": "transitional myocyte of sinoatrial node", "taxa": []}
{"type": "biolink:Cell", "ic": 92.76600187037766, "identifiers": [{"i": "CL:0001069", "l": "group 2 innate lymphoid cell", "d": ["An innate lymphoid cell that is capable of producing T-helper 2-cell associated cytokines upon stimulation."], "t": []}], "preferred_name": "group 2 innate lymphoid cell", "taxa": []}
{"type": "biolink:Cell", "ic": 72.615132056446, "identifiers": [{"i": "CL:0000018", "l": "spermatid", "d": ["A male germ cell that develops from the haploid secondary spermatocytes. Without further division, spermatids undergo structural changes and give rise to spermatozoa."], "t": []}, {"i": "UMLS:C0037857", "l": "Spermatid", "d": [], "t": []}, {"i": "NCIT:C12604", "l": "Spermatid", "d": ["An immature male germ cell that is formed by meiotic division of a secondary spermatocyte. Spermatids develop into spermatozoa."], "t": []}, {"i": "MESH:D013087", "l": "Spermatids", "d": [], "t": []}, {"i": "SNOMEDCT:38326003", "l": "", "d": [], "t": []}], "preferred_name": "spermatid", "taxa": []}
{"type": "biolink:Cell", "ic": 66.06728129612489, "identifiers": [{"i": "CL:0007004", "l": "premigratory neural crest cell", "d": ["Cell that is part of the neural crest region of the neuroepithelium, prior to migration. Note that not all premigratory neural crest cells may become migratory neural crest cells."], "t": []}], "preferred_name": "premigratory neural crest cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0000915", "l": "CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell", "d": ["An alpha-beta intraepithelial T cell with the phenotype CD8-alpha-alpha-positive located in the columnar epithelium of the gastrointestinal tract. These cells have a memory phenotype of CD2-negative and CD5-negative."], "t": []}], "preferred_name": "CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5170900", "l": "Leukemia markers | Cerebral spinal fluid | Cell markers", "d": [], "t": []}], "preferred_name": "Leukemia markers | Cerebral spinal fluid | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5172504", "l": "Mesothelial cells | Cerebral spinal fluid | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Mesothelial cells | Cerebral spinal fluid | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": 84.21065366064373, "identifiers": [{"i": "CL:0000611", "l": "eosinophil progenitor cell", "d": ["Any granulocytopoietic cell that has part some transcription factor PU.1 and has part some CCAAT/enhancer-binding protein alpha and has part some erythroid transcription factor and lacks plasma membrane part some CD19 molecule and lacks plasma membrane part some CD4 molecule and lacks plasma membrane part some integrin alpha-M and lacks plasma membrane part some CD3 epsilon and lacks plasma membrane part some neural cell adhesion molecule 1 and lacks plasma membrane part some CD2 molecule and lacks plasma membrane part some T-cell surface glycoprotein CD8 alpha chain and lacks plasma membrane part some membrane-spanning 4-domains subfamily A member 1 and lacks plasma membrane part some T-cell surface glycoprotein CD5 and lacks plasma membrane part some CD14 molecule and lacks plasma membrane part some lymphocyte antigen 6G and lacks plasma membrane part some lymphocyte antigen 76 (mouse) and has plasma membrane part some CD34 molecule and has plasma membrane part some ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 and has plasma membrane part some interleukin-3 receptor class 2 alpha chain and has plasma membrane part some interleukin-5 receptor subunit alpha and has plasma membrane part some mast/stem cell growth factor receptor and is capable of some eosinophil differentiation."], "t": []}], "preferred_name": "eosinophil progenitor cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4307045", "l": "Astro-TE NN_3 Fam163a astrocyte (Mmus)", "d": ["A astrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of S1pr1 (Mmus), Fam163a (Mmus), Kcnq3 (Mmus), Kcnq1ot1 (Mmus). It is distinguished from other Astro-TE NN_3 cells by expression of Fam163a, Nr2f1, Kcnq1ot1. These cells are located in the Isocortex, Olfactory areas . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5225 Astro-TE NN_3."], "t": []}], "preferred_name": "Astro-TE NN_3 Fam163a astrocyte (Mmus)", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0333859", "l": "Convoluted cell", "d": [], "t": []}, {"i": "SNOMEDCT:33873001", "l": "", "d": [], "t": []}], "preferred_name": "Convoluted cell", "taxa": []}
{"type": "biolink:Cell", "ic": 92.76600187037766, "identifiers": [{"i": "CL:1001285", "l": "vasa recta descending limb cell", "d": ["A cell that is part of some vasa recta descending limb."], "t": []}], "preferred_name": "vasa recta descending limb cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4079031", "l": "thoracic dorsal root ganglion Nav1.7 neuron", "d": ["A nociceptor whose soma is located in the thoracic dorsal root ganglion and that expresses the voltage-gated sodium channel Nav1.7 (encoded by SCN9A). This neuron is characterized by Nav1.7-dependent action potential initiation and amplification, which is essential for normal pain sensation in humans. Nav1.7 contributes approximately 50% of total sodium channel current in human DRG nociceptors (Chang et al. 2018, PMID:28424991). In human DRG, Nav1.7 immunoreactivity is detected in 54-57% of TrkA-positive neurons (Rostock et al. 2018, PMID:29229553). Human genetic evidence confirms Nav1.7 as necessary and sufficient for nociceptive function in these neurons."], "t": []}], "preferred_name": "thoracic dorsal root ganglion Nav1.7 neuron", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:2000062", "l": "placental villus capillary endothelial cell", "d": ["Any capillary endothelial cell that is part of a placenta."], "t": []}], "preferred_name": "placental villus capillary endothelial cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0002621", "l": "gingival epithelial cell", "d": ["Any stratified squamous epithelial cell that is part of some gingival epithelium."], "t": []}], "preferred_name": "gingival epithelial cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0545577", "l": "Marrow plasma cell", "d": [], "t": []}], "preferred_name": "Marrow plasma cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C2349140", "l": "WT1-Sensitized Allogeneic T-Lymphocytes", "d": [], "t": []}, {"i": "NCIT:C74091", "l": "WT1-Sensitized Allogeneic T-Lymphocytes", "d": ["A population of allogeneic T-cells sensitized with Wilms tumor 1 (WT1) antigen with potential immunostimulatory and antineoplastic activities. Upon administration, WT1-sensitized T cells may bind to and lyse WT1-expressing tumor cells. WT1 antigen, a zinc finger DNA-binding protein acting as a transcriptional activator or repressor depending on the cellular or chromosomal context, is overexpressed in leukemic cells and in a vast number of nonhematological solid tumors."], "t": []}], "preferred_name": "WT1-Sensitized Allogeneic T-Lymphocytes", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5556788", "l": "Anti-CD7 CAR T Cells SenL-T7", "d": [], "t": []}, {"i": "NCIT:C181024", "l": "Anti-CD7 CAR T Cells SenL-T7", "d": ["A preparation of T-lymphocytes that have been genetically engineered to express a chimeric antigen receptor (CAR) directed against the tumor-associated antigen (TAA) CD7, with potential immunostimulating and antineoplastic activities. Upon administration, the anti-CD7 CAR T cells SenL-T7 specifically recognize and bind to CD7-expressing tumor cells, resulting in specific T-cell-mediated tumor cell lysis. CD7 is a transmembrane glycoprotein expressed by T-cells and natural killer (NK) cells and their precursors. It is expressed in the majority of lymphoblastic T-cell leukemias and lymphomas and in a subset of peripheral T-cell lymphomas."], "t": []}], "preferred_name": "Anti-CD7 CAR T Cells SenL-T7", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5220577", "l": "Epithelial cells|Urine/Urine sed", "d": [], "t": []}], "preferred_name": "Epithelial cells|Urine/Urine sed", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0487022", "l": "Irregularly contracted cell", "d": [], "t": []}, {"i": "SNOMEDCT:725684008", "l": "", "d": [], "t": []}], "preferred_name": "Irregularly contracted cell", "taxa": []}
{"type": "biolink:Cell", "ic": 84.21065366064373, "identifiers": [{"i": "UMLS:C1510783", "l": "Adenocarcinoma Spindle Cell", "d": [], "t": []}, {"i": "NCIT:C37108", "l": "Adenocarcinoma Spindle Cell", "d": [], "t": []}], "preferred_name": "Adenocarcinoma Spindle Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5206714", "l": "Indium In 111-Autologous CMV-pp65-LAMP mRNA Loaded Dendritic Cells", "d": [], "t": []}, {"i": "NCIT:C162641", "l": "Indium In 111-Autologous CMV-pp65-LAMP mRNA Loaded Dendritic Cells", "d": ["A radioimmunoconjugate composed of mature autologous dendritic cells (DCs) generated from peripheral blood leukocytes pulsed with mRNA encoding for a fusion protein comprised of the human cytomegalovirus (CMV) matrix protein pp65 (65 kDa lower matrix phosphoprotein; UL83) fused with the lysosome-associated membrane protein (pp65-LAMP) and radiolabeled with the isotope indium In 111, with potential ability to track DC migration upon single-photon emission computed tomography (SPECT)/ computed tomography (CT). Upon intradermal injection of the indium In 111-autologous CMV pp65-LAMP mRNA loaded DCs into the groin area, the DCs migrate in vivo to the inguinal lymph nodes. Upon SPECT/CT imaging, DC in vivo migration to the lymph nodes can be assessed."], "t": []}], "preferred_name": "Indium In 111-Autologous CMV-pp65-LAMP mRNA Loaded Dendritic Cells", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5783501", "l": "CD19-targeted CAR T Cells BZ019", "d": [], "t": []}, {"i": "NCIT:C190113", "l": "CD19-targeted CAR T Cells BZ019", "d": ["A preparation of T-lymphocytes that have been genetically modified and transduced with a non-viral vector expressing a chimeric antigen receptor (CAR) targeting the tumor-associated antigen (TAA) CD19 and containing, as of yet undisclosed co-stimulatory signaling domains, with potential immunostimulating and antineoplastic activities. Upon administration, CD19-targeted CAR T cells BZ019 recognize and bind to CD19-expressing tumor cells, thereby inducing selective toxicity in CD19-expressing tumor cells. CD19 antigen is a B-cell-specific cell surface antigen overexpressed in B-cell lineage malignancies."], "t": []}], "preferred_name": "CD19-targeted CAR T Cells BZ019", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1183498", "l": "Primitive node cell", "d": [], "t": []}], "preferred_name": "Primitive node cell", "taxa": []}
{"type": "biolink:Cell", "ic": 84.83823963392128, "identifiers": [{"i": "UMLS:C1513996", "l": "Neoplastic Large B-Lymphocyte with Pale Cytoplasm", "d": [], "t": []}, {"i": "NCIT:C38660", "l": "Neoplastic Large B-Lymphocyte with Pale Cytoplasm", "d": [], "t": []}], "preferred_name": "Neoplastic Large B-Lymphocyte with Pale Cytoplasm", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5157386", "l": "CD20+FMC7+ cells | Tissue and Smears | Cell markers", "d": [], "t": []}], "preferred_name": "CD20+FMC7+ cells | Tissue and Smears | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4033173", "l": "pelvic ganglion nNOS/VAChT neuron", "d": ["A parasympathetic neuron that has the soma located in the pelvic ganglion and expresses the marker neuronal nitric oxide synthase 1(nNOS) and vesicular acetylcholine transporter (VAChT)."], "t": []}], "preferred_name": "pelvic ganglion nNOS/VAChT neuron", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4511161", "l": "Blast cell positive for cytoplasmic CD13 antigen", "d": [], "t": []}, {"i": "SNOMEDCT:725480006", "l": "", "d": [], "t": []}], "preferred_name": "Blast cell positive for cytoplasmic CD13 antigen", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C2936409", "l": "Palisade Parenchyma Cells", "d": [], "t": []}], "preferred_name": "Palisade Parenchyma Cells", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5700416", "l": "Autologous Anti-mesothelin T-cell Receptor Fusion Construct T-cells TC-210", "d": [], "t": []}], "preferred_name": "Autologous Anti-mesothelin T-cell Receptor Fusion Construct T-cells TC-210", "taxa": []}
{"type": "biolink:Cell", "ic": 69.54608552448124, "identifiers": [{"i": "CL:0000202", "l": "auditory hair cell", "d": ["A mechanoreceptor cell of the auditory or vestibular system that is sensitive to auditory stimuli. The accessory sensory structures are arranged so that appropriate stimuli cause movement of the hair-like projections (stereocilia and kinocilia) which relay the information centrally in the nervous system."], "t": []}], "preferred_name": "auditory hair cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C3273371", "l": "CD4 Positive Memory T-Lymphocyte", "d": [], "t": []}, {"i": "NCIT:C97349", "l": "CD4 Positive Memory T-Lymphocyte", "d": ["A mature T lymphocyte that has encountered antigen at a previous time and is primed to react strongly during its next encounter with that antigen. These cells can be identified by the presence of both the CD4 and CD45RO molecules on their surface."], "t": []}], "preferred_name": "CD4 Positive Memory T-Lymphocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "CL:0000430", "l": "xanthophore cell", "d": ["A pigment cell derived from the neural crest. Contains cartenoid pigments in structures called pterinosomes or xanthosomes. This gives an appearance ranging from a golden yellow to orange and red."], "t": []}], "preferred_name": "xanthophore cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0022539", "l": "KB Cells", "d": [], "t": []}, {"i": "MESH:D007624", "l": "KB Cells", "d": [], "t": []}], "preferred_name": "KB Cells", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4072032", "l": "VIP GABAergic interneuron (Homo sapiens)", "d": ["A transcriptomically distinct GABAergic neuron that expresses the vasoactive intestinal polypeptide and that has its soma located in the forebrain. The standard transcriptomic reference data for this cell type can be found on the CellxGene census under the collection: 'Transcriptomic cytoarchitecture reveals principles of human neocortex organization', dataset: 'Supercluster: CGE-derived interneurons', Author Categories: 'CrossArea_subclass', cluster Vip."], "t": []}], "preferred_name": "VIP GABAergic interneuron (Homo sapiens)", "taxa": []}
{"type": "biolink:Cell", "ic": 82.16838616155795, "identifiers": [{"i": "CL:0000442", "l": "follicular dendritic cell", "d": ["A cell with extensive dendritic processes found in the B cell areas (primary follicles and germinal centers) of lymphoid tissue. They are unrelated to the dendritic cell associated with T cells. Follicular dendritic cells have Fc receptors and C3b receptors, but unlike other dendritic cells, they do not process or present antigen in a way that allows recognition by T cells. Instead, they hold antigen in the form of immune complexes on their surfaces for long periods and can present antigen to B cells during an immune response."], "t": []}, {"i": "UMLS:C0242245", "l": "Dendritic Cells, Follicular", "d": [], "t": []}, {"i": "NCIT:C12622", "l": "Follicular Dendritic Cell", "d": ["Antigen Presenting Cells (APCs) located in the follicles of secondary lymphoid organs.  These dendritic cells are unique because of their location, primarily in lymphoid follicles, and because of their function in retaining antigen molecules for extended periods of time and serving as APCs for B cells."], "t": []}, {"i": "MESH:D020566", "l": "Dendritic Cells, Follicular", "d": [], "t": []}, {"i": "SNOMEDCT:56685008", "l": "", "d": [], "t": []}], "preferred_name": "follicular dendritic cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5909951", "l": "Autologous 19-28z/IL-18 CAR T-lymphocytes", "d": [], "t": []}, {"i": "NCIT:C204737", "l": "Autologous 19-28z/IL-18 CAR T-lymphocytes", "d": ["A preparation of autologous T-lymphocytes engineered to express a chimeric antigen receptor (CAR) specific for the tumor-associated antigen (TAA) cluster of differentiation 19 (CD19) fused to the extracellular, transmembrane and intracellular signaling domains of the T-cell co-stimulatory receptor CD28 and the cytoplasmic signaling domain of the zeta chain of the TCR/CD3 complex (CD3-zeta) (19-28z), and expressing the human pro-inflammatory cytokine interleukin 18 (IL-18), with potential immunomodulating and antineoplastic activities. Upon intravenous administration, autologous 19-28z/IL-18 CAR T-lymphocytes target, bind to, and induce selective toxicity in CD19-expressing tumor cells. IL-18 promotes T-cell persistence and potentiates the immune response against tumor cells. CD19 is a B-cell-specific cell surface antigen overexpressed in B-cell lineage tumors. Incorporation of costimulatory signaling domains increases human T-cell function, expansion, and survival."], "t": []}], "preferred_name": "Autologous 19-28z/IL-18 CAR T-lymphocytes", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5173472", "l": "Monocytes+Macrophages | Synovial fluid | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Monocytes+Macrophages | Synovial fluid | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5179518", "l": "Reticulocytes | Fetus | Blood | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Reticulocytes | Fetus | Blood | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0002133", "l": "stromal cell of ovarian cortex", "d": ["A stromal cell of the ovarian cortex."], "t": []}, {"i": "UMLS:C2327311", "l": "Stromal cell of ovarian cortex", "d": [], "t": []}], "preferred_name": "stromal cell of ovarian cortex", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4033021", "l": "myoepithelial cell of trachea gland", "d": ["A myoepithelial cell that is part of a submucosal gland of the trachea."], "t": []}], "preferred_name": "myoepithelial cell of trachea gland", "taxa": []}
{"type": "biolink:Cell", "ic": 49.71451615134895, "identifiers": [{"i": "CL:0000095", "l": "neuron associated cell", "d": [], "t": []}], "preferred_name": "neuron associated cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4079030", "l": "thoracic dorsal root ganglion endothelin-1 neuron", "d": ["A sensory neuron whose soma is located in the thoracic dorsal root ganglion and that expresses endothelin-1 (EDN1). In rat DRG, EDN1 immunoreactivity has been detected in a subset of neuron somata (Giaid et al. 1989, PMID:2678100). Endothelin-1 acts as an endogenous pain mediator, sensitizing nociceptors through activation of ETA and ETB receptors, and these neurons are implicated in vascular pain signalling. EDN1-expressing DRG neurons have been characterized in rat; their prevalence and properties in human DRG remain to be systematically determined, as EDN1 is not yet represented in human DRG single-cell transcriptomic datasets."], "t": []}], "preferred_name": "thoracic dorsal root ganglion endothelin-1 neuron", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C4527154", "l": "TCR-specific, alpha Fetoprotein-enhanced Autologous T Lymphocytes", "d": [], "t": []}, {"i": "NCIT:C136982", "l": "TCR-specific, alpha Fetoprotein-enhanced Autologous T Lymphocytes", "d": ["A preparation of human autologous T-lymphocytes transduced with a viral vector encoding for a T-cell receptor (TCR) specific for human alpha-fetoprotein (AFP), with potential antineoplastic activity. Following administration, the TCR-specific, alpha fetoprotein-enhanced autologous T-lymphocytes recognize and bind to AFP antigen-positive cells, which results in lysis and killing of AFP-positive cancer cells. AFP is overexpressed in a variety of cancers."], "t": []}], "preferred_name": "TCR-specific, alpha Fetoprotein-enhanced Autologous T Lymphocytes", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "UMLS:C1710442", "l": "Totipotent Primordial Germ Cell", "d": [], "t": []}, {"i": "NCIT:C45734", "l": "Totipotent Primordial Germ Cell", "d": ["One of the earliest cells of an organism that will be able to reproduce that kind of organism. It is able to develop into any variety of germ cell."], "t": []}], "preferred_name": "Totipotent Primordial Germ Cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5171964", "l": "Malignant cells | Pleural fluid | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Malignant cells | Pleural fluid | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C3832086", "l": "Human Cord Blood Hematopoietic Progenitor Cell 500000000 in 35 mL INTRAVENOUS INJECTION, SOLUTION [ALLOCORD]", "d": [], "t": []}], "preferred_name": "Human Cord Blood Hematopoietic Progenitor Cell 500000000 in 35 mL INTRAVENOUS INJECTION, SOLUTION [ALLOCORD]", "taxa": []}
{"type": "biolink:Cell", "ic": 76.78008365410358, "identifiers": [{"i": "UMLS:C1514047", "l": "Neoplastic Neuroendocrine Spindle Cell", "d": [], "t": []}, {"i": "NCIT:C36935", "l": "Neoplastic Neuroendocrine Spindle Cell", "d": [], "t": []}], "preferred_name": "Neoplastic Neuroendocrine Spindle Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 66.1054533964356, "identifiers": [{"i": "CL:0002681", "l": "kidney cortical cell", "d": ["A cell that is part of a cortex of kidney."], "t": []}], "preferred_name": "kidney cortical cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5174860", "l": "Nonhematic cells | Body fluid | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Nonhematic cells | Body fluid | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5708809", "l": "Dust Vitreous Seed", "d": [], "t": []}, {"i": "NCIT:C189885", "l": "Dust Vitreous Seed", "d": ["A histopathologic classification of vitreous seeding that is characterized by small, localized granules of tumor cells."], "t": []}], "preferred_name": "Dust Vitreous Seed", "taxa": []}
{"type": "biolink:Cell", "ic": 73.49439205968403, "identifiers": [{"i": "UMLS:C1513710", "l": "Mucin-Producing Neoplastic Epithelial Cell", "d": [], "t": []}, {"i": "NCIT:C36891", "l": "Mucin-Producing Neoplastic Epithelial Cell", "d": [], "t": []}], "preferred_name": "Mucin-Producing Neoplastic Epithelial Cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C3824982", "l": "Pancreatic acinar cells--Cancer", "d": [], "t": []}], "preferred_name": "Pancreatic acinar cells--Cancer", "taxa": []}
{"type": "biolink:Cell", "ic": 79.9528279018387, "identifiers": [{"i": "UMLS:C1514019", "l": "Neoplastic Medium-Sized to Large Lymphocyte", "d": [], "t": []}, {"i": "NCIT:C36992", "l": "Neoplastic Medium-Sized to Large Lymphocyte", "d": [], "t": []}], "preferred_name": "Neoplastic Medium-Sized to Large Lymphocyte", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1440325", "l": "CD49e+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:1372902004", "l": "", "d": [], "t": []}], "preferred_name": "CD49e+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4310088", "l": "BF SKOR1 Glut glutamatergic neuron of the basal ganglia (Primate)", "d": ["A glutamatergic neuron of the basal ganglia of the Primates brain. These cells are located in the striatum, external segment of globus pallidus . Reference transcriptomic data for this type can be found in the dataset/taxonomy - HMBA Basal Ganglia Consensus Taxonomy in cell set Group:BF SKOR1 Glut."], "t": []}], "preferred_name": "BF SKOR1 Glut glutamatergic neuron of the basal ganglia (Primate)", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1882409", "l": "Pluripotent Bronchial Precursor Cell", "d": [], "t": []}, {"i": "NCIT:C55819", "l": "Pluripotent Bronchial Precursor Cell", "d": [], "t": []}], "preferred_name": "Pluripotent Bronchial Precursor Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4052064", "l": "nail matrix keratinocyte", "d": ["A keratinocyte that is part of the nail matrix epithelium, distinguished by its high proliferative capacity and its role in nail plate formation via onychokeratinization, a differentiation process that uniquely bypasses the formation of a granular layer, resulting in the production of hard, compact keratin. Unlike skin epidermal keratinocytes, this cell expresses a distinctive mix of hard (hair-type) and select epidermal keratins (Kitahara and Ogawa, 1993). In humans, LGR6 and WNT6 are enriched in the basal compartment, with LGR6 marking nail stem cells in both mice and humans, and exhibiting strong expression in the human proximal nail matrix (Kim et al., 2021)."], "t": []}], "preferred_name": "nail matrix keratinocyte", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1979063", "l": "Blasts.CD1", "d": [], "t": []}], "preferred_name": "Blasts.CD1", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5666888", "l": "Allogeneic Anti-CD38 DAR-T Cells STI-1492", "d": [], "t": []}, {"i": "NCIT:C182613", "l": "Allogeneic Anti-CD38 DAR-T Cells STI-1492", "d": ["A preparation of human allogeneic T-lymphocytes that are gene-edited with the clustered regularly interspaced short palindromic repeats (CRISPR)-Cas9 nuclease complex to disrupt the expression of endogenous T-cell receptor (TCR) alpha and to express a dimeric antigen receptor (DAR) composed of a fragment antigen-binding variable region (Fab) recognizing the tumor-associated antigen (TAA) cluster of differentiation 38 (CD38), linked to the intracellular signaling domains of 4-1BB (CD137) and the zeta chain of the TCR/CD3 complex (TCRzeta; CD247; CD3zeta), with potential immunomodulating and antineoplastic activities. Upon intravenous administration, allogeneic anti-CD38 DAR-T cells STI-1492 are directed to and induce selective toxicity in CD38-expressing tumor cells. CD38, a type II transmembrane glycoprotein, is present on various immune cells and hematologic malignancies, and its expression has been correlated with poor prognosis. The disruption of endogenous TCR alpha prevents graft-versus-host disease (GvHD)."], "t": []}], "preferred_name": "Allogeneic Anti-CD38 DAR-T Cells STI-1492", "taxa": []}
{"type": "biolink:Cell", "ic": 89.40238429118027, "identifiers": [{"i": "UMLS:C1522160", "l": "Mouse Granulocyte", "d": [], "t": []}, {"i": "NCIT:C22590", "l": "Mouse Granulocyte", "d": [], "t": []}], "preferred_name": "Mouse Granulocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5984537", "l": "Allogeneic Virus-specific T-lymphocytes", "d": [], "t": []}, {"i": "NCIT:C212854", "l": "Allogeneic Virus-specific T-lymphocytes", "d": ["A preparation of allogeneic donor-derived T-lymphocytes that are specifically reactive to adenovirus (AdV), cytomegalovirus (CMV), Epstein-Barr virus (EBV) and human polyomavirus type I (BKV), with potential antiviral activity. Upon administration, allogeneic VSTs may kill AdV, CMV, EBV and/or BKV-infected cells, thereby preventing or reducing the severity of viral infections by these pathogens."], "t": []}], "preferred_name": "Allogeneic Virus-specific T-lymphocytes", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5380747", "l": "CD21LowCD38- cell", "d": [], "t": []}, {"i": "SNOMEDCT:1373289006", "l": "", "d": [], "t": []}], "preferred_name": "CD21LowCD38- cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C6065117", "l": "EDIT-301", "d": [], "t": []}], "preferred_name": "EDIT-301", "taxa": []}
{"type": "biolink:Cell", "ic": 71.39747969210477, "identifiers": [{"i": "UMLS:C1518369", "l": "Non-Keratinizing Malignant Squamous Cell", "d": [], "t": []}, {"i": "NCIT:C36792", "l": "Non-Keratinizing Malignant Squamous Cell", "d": ["A malignant squamous cell that does not produce keratin."], "t": []}], "preferred_name": "Non-Keratinizing Malignant Squamous Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 88.20185721311867, "identifiers": [{"i": "CL:4023097", "l": "arachnoid barrier cell", "d": ["A mesothelial fibroblast of the arachnoid barrier layer. Arachnoid barrier cells make up the tight-junctioned layer in the leptomeninx that functions as the physiologic barrier between the cerebrospinal fluid in the subarachnoid space and the fenestrated capillaries in the dura."], "t": []}], "preferred_name": "arachnoid barrier cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C3899738", "l": "CXCR2-transduced Autologous Tumor Infiltrating Lymphocytes", "d": [], "t": []}, {"i": "NCIT:C120001", "l": "CXCR2-transduced Autologous Tumor Infiltrating Lymphocytes", "d": ["A preparation of autologous tumor infiltrating lymphocytes (TILs) that are transduced, ex vivo, with a retroviral vector encoding a gene for CXC chemokine receptor 2 (CXCR2), with potential antineoplastic activity. Upon administration of the CXCR2-transduced autologous TILs, the CXCR2-expressing T-cells selectively migrate toward tumor cells expressing CXCR2 ligands, which leads to tumor cell killing. CXCR2 expression allows for optimal TIL migration towards tumor cells and enhances the TILs anti-tumor activity. This leads to a reduction in both tumor cell proliferation and survival. CXCR2, a transmembrane protein also known as IL-8 receptor B (IL-8RB), plays a key role in inflammation and cancer progression. Certain CXCR2 ligands, such as CXCL1 and CXCL8 (IL-8), are expressed by tumor cells."], "t": []}], "preferred_name": "CXCR2-transduced Autologous Tumor Infiltrating Lymphocytes", "taxa": []}
{"type": "biolink:Cell", "ic": 70.08390831208611, "identifiers": [{"i": "UMLS:C1510738", "l": "Abnormal Trophoblastic Cell", "d": [], "t": []}, {"i": "NCIT:C36799", "l": "Abnormal Trophoblastic Cell", "d": [], "t": []}], "preferred_name": "Abnormal Trophoblastic Cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1631818", "l": "CD20+CD117+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:1372992005", "l": "", "d": [], "t": []}], "preferred_name": "CD20+CD117+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C6049699", "l": "Rondecabtagene Autoleucel", "d": [], "t": []}], "preferred_name": "Rondecabtagene Autoleucel", "taxa": []}
{"type": "biolink:Cell", "ic": 92.76600187037766, "identifiers": [{"i": "CL:0002480", "l": "nasal mucosa goblet cell", "d": ["A goblet cell located in the nasal epithelium."], "t": []}], "preferred_name": "nasal mucosa goblet cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0003045", "l": "M12 retinal ganglion cell", "d": ["A bistratified ganglion cell with larger, asymetric dendritic fields that terminate in S2 and S4."], "t": []}], "preferred_name": "M12 retinal ganglion cell", "taxa": []}
{"type": "biolink:Cell", "ic": 92.76600187037766, "identifiers": [{"i": "CL:0002657", "l": "glandular cell of esophagus", "d": ["A glandular epithelial cell of the esophagus."], "t": []}, {"i": "UMLS:C1516963", "l": "Glandular cell of esophagus", "d": [], "t": []}, {"i": "NCIT:C32537", "l": "Esophageal Glandular Cell", "d": ["An epithelial cell that covers the lower third of the esophageal lumen. It is also found in the submucosal glands of the esophagus."], "t": []}], "preferred_name": "glandular cell of esophagus", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1268002", "l": "Lymphocyte positive for CD128 antigen", "d": [], "t": []}, {"i": "SNOMEDCT:117442001", "l": "", "d": [], "t": []}], "preferred_name": "Lymphocyte positive for CD128 antigen", "taxa": []}
{"type": "biolink:Cell", "ic": 58.487292272771946, "identifiers": [{"i": "CL:0000206", "l": "chemoreceptor cell", "d": ["A cell specialized to detect chemical substances and relay that information centrally in the nervous system. Chemoreceptors may monitor external stimuli, as in taste and olfaction, or internal stimuli, such as the concentrations of oxygen and carbon dioxide in the blood."], "t": []}, {"i": "UMLS:C0008010", "l": "Chemoreceptor Cells", "d": [], "t": []}, {"i": "MESH:D002628", "l": "Chemoreceptor Cells", "d": [], "t": []}], "preferred_name": "chemoreceptor cell", "taxa": []}
{"type": "biolink:Cell", "ic": 81.743421370964, "identifiers": [{"i": "CL:0001204", "l": "CD4-positive, alpha-beta memory T cell, CD45RO-positive", "d": ["CD4-positive, alpha-beta long-lived T cell with the phenotype CD45RO-positive and CD127-positive. This cell type is also described as being CD25-negative."], "t": []}], "preferred_name": "CD4-positive, alpha-beta memory T cell, CD45RO-positive", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4511593", "l": "Population of all immature reticulocytes in portion of fluid", "d": [], "t": []}, {"i": "SNOMEDCT:725998003", "l": "", "d": [], "t": []}], "preferred_name": "Population of all immature reticulocytes in portion of fluid", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0002094", "l": "interstitial cell of ovary", "d": ["A cell that makes up the loose connective tissue of the ovary."], "t": []}], "preferred_name": "interstitial cell of ovary", "taxa": []}
{"type": "biolink:Cell", "ic": 87.18682603146104, "identifiers": [{"i": "CL:0002035", "l": "Slamf1-negative multipotent progenitor cell", "d": ["A hematopoietic progenitor that has restricted self-renewal capability. Cell is Kit-positive, Ly6-positive, CD150-negative and Flt3-negative."], "t": []}], "preferred_name": "Slamf1-negative multipotent progenitor cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5669565", "l": "Rebonuputemcel", "d": [], "t": []}, {"i": "NCIT:C184826", "l": "Rebonuputemcel", "d": [], "t": []}], "preferred_name": "Rebonuputemcel", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5983867", "l": "Allogeneic TCRa/b-depleted HA-1 Minor Histocompatibility Antigen-Reactive TCR-Modified RQR8-expressing T Cells BSB-1001", "d": [], "t": []}, {"i": "NCIT:C212124", "l": "Allogeneic TCRa/b-depleted HA-1 Minor Histocompatibility Antigen-Reactive TCR-Modified RQR8-expressing T Cells BSB-1001", "d": ["A preparation of T-cell receptor (TCR) alpha and beta (TCRa/b)-depleted donor-derived T-lymphocytes that have been transduced with a lentivirus vector encoding a TCR specific for HLA-A*02:01-restricted minor histocompatibility antigen HA-1 (HA1) and expressing RQR8, with potential immunomodulating and antineoplastic activities. Following HLA-matched allogeneic hematopoietic cell transplantation (HCT) in HLA-A*02:01 positive patients, allogeneic TCRa/b-depleted HA-1 minor histocompatibility antigen-reactive TCR-modified RQR8-expressing T cells BSB-1001 specifically recognize and bind to HA-1 expressed on tumor cells. This may lead to cytotoxic T-lymphocyte (CTL)-mediated elimination of tumor cells expressing HLA-A*02:01 HA-1. HA-1 is a lineage-specific antigen found on leukemia cells. BSB-1001 carries the universal RQR8 safety \"off\" switch, which allows selective removal of the T-cells through both complement-dependent cytotoxicity (CDC) and antibody-dependent cellular cytotoxicity (ADCC) following administration of rituximab if unacceptable side-effects occur. CRISPR-cas9 editing of the donor T-cells deletes the endogenous TCRa/b chains. Depletion of TCRa/b increases expression of the transduced TCR and reduces risk of graft-versus-host disease (GVHD) caused by native TCRs."], "t": []}], "preferred_name": "Allogeneic TCRa/b-depleted HA-1 Minor Histocompatibility Antigen-Reactive TCR-Modified RQR8-expressing T Cells BSB-1001", "taxa": []}
{"type": "biolink:Cell", "ic": 84.83823963392128, "identifiers": [{"i": "CL:0002252", "l": "epithelial cell of esophagus", "d": ["An epithelial cell of the lining of the esophagus."], "t": []}, {"i": "UMLS:C1179549", "l": "Epithelial cell of esophagus", "d": [], "t": []}], "preferred_name": "epithelial cell of esophagus", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C4288626", "l": "NK Cell-enriched Donor Lymphocytes", "d": [], "t": []}, {"i": "NCIT:C127939", "l": "NK Cell-enriched Donor Lymphocytes", "d": ["A preparation of donor-derived lymphocytes that are enriched for donor-derived natural killer (NK) cells, with direct tumor cytotoxic activity. Following allogeneic stem cell transplantation and subsequent infusion of the NK cell-enriched donor lymphocytes, these cells recognize and bind to tumor cells, upon which they secrete and release perforins, granzymes, and cytokines, which results in cancer cell lysis. Infusion of donor lymphocytes is limited by the risk of graft-versus-host disease (GVHD) and NK cells normally constitute only a small portion of circulating lymphocytes. Therefore, NK cell-enrichment may result in higher amounts of NK cells per infusion and improved anti-tumor immunity without increasing the risk of GVHD."], "t": []}], "preferred_name": "NK Cell-enriched Donor Lymphocytes", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5964753", "l": "Cesnicabtagene Autoleucel", "d": [], "t": []}], "preferred_name": "Cesnicabtagene Autoleucel", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1545228", "l": "Cells.CD3-CD57+", "d": [], "t": []}, {"i": "SNOMEDCT:1373181001", "l": "", "d": [], "t": []}], "preferred_name": "Cells.CD3-CD57+", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0682524", "l": "fibroblast cell line", "d": [], "t": []}], "preferred_name": "fibroblast cell line", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5157454", "l": "CD3+CD8+ (T8 suppressor) cells | Blood | Cell markers", "d": [], "t": []}], "preferred_name": "CD3+CD8+ (T8 suppressor) cells | Blood | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1267927", "l": "Lymphocyte positive for CD44R antigen", "d": [], "t": []}, {"i": "SNOMEDCT:117371001", "l": "", "d": [], "t": []}], "preferred_name": "Lymphocyte positive for CD44R antigen", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1267960", "l": "Lymphocyte positive for CD66C antigen", "d": [], "t": []}, {"i": "SNOMEDCT:117401004", "l": "", "d": [], "t": []}], "preferred_name": "Lymphocyte positive for CD66C antigen", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5666883", "l": "Autologous Tumor Infiltrating Lymphocytes ITIL-168", "d": [], "t": []}, {"i": "NCIT:C182132", "l": "Autologous Tumor Infiltrating Lymphocytes ITIL-168", "d": ["A preparation of autologous tumor infiltrating lymphocytes (TILs) derived from each patient's digested and cryopreserved tumor, with potential immunomodulating and antineoplastic activities. Upon administration back into the patient, the autologous TILs ITIL-168 specifically recognize and kill the patient's tumor cells."], "t": []}], "preferred_name": "Autologous Tumor Infiltrating Lymphocytes ITIL-168", "taxa": []}
{"type": "biolink:Cell", "ic": 76.78008365410358, "identifiers": [{"i": "UMLS:C1709898", "l": "Renal Pelvis Urothelial Cell", "d": [], "t": []}, {"i": "NCIT:C54557", "l": "Renal Pelvis Urothelial Cell", "d": [], "t": []}], "preferred_name": "Renal Pelvis Urothelial Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0002121", "l": "CD24-negative CD38-negative IgG-negative class switched memory B cell", "d": ["A CD24-negative CD38-negative IgG-negative memory B cell is a CD38-negative IgG-negative class switched memory B cell that lacks IgG on the cell surface with the phenotype CD24-negative, CD38-negative, and IgG-negative."], "t": []}], "preferred_name": "CD24-negative CD38-negative IgG-negative class switched memory B cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0001003", "l": "mature CD8-alpha-negative CD11b-positive dendritic cell", "d": ["Mature CD8-alpha-negative CD11b-positive dendritic cell is a CD8-alpha-negative CD11b-positive dendritic cell that is CD80-high, CD86-high, MHCII-high and is CD83-positive."], "t": []}], "preferred_name": "mature CD8-alpha-negative CD11b-positive dendritic cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1267994", "l": "Lymphocyte positive for CD107B antigen", "d": [], "t": []}, {"i": "SNOMEDCT:117434002", "l": "", "d": [], "t": []}], "preferred_name": "Lymphocyte positive for CD107B antigen", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4240450", "l": "Vascular smooth muscle cell of arteriole", "d": [], "t": []}], "preferred_name": "Vascular smooth muscle cell of arteriole", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5157402", "l": "CD23 cells | Blood | Cell markers", "d": [], "t": []}], "preferred_name": "CD23 cells | Blood | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1979779", "l": "Other cells", "d": [], "t": []}], "preferred_name": "Other cells", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1267990", "l": "Lymphocyte positive for CD104 antigen", "d": [], "t": []}, {"i": "SNOMEDCT:117430006", "l": "", "d": [], "t": []}], "preferred_name": "Lymphocyte positive for CD104 antigen", "taxa": []}
{"type": "biolink:Cell", "ic": 63.93930097063971, "identifiers": [{"i": "CL:0000233", "l": "platelet", "d": ["A non-nucleated disk-shaped cell formed by extrusion from megakaryocytes, found in the blood of all mammals, and mainly involved in blood coagulation."], "t": []}, {"i": "UMLS:C0005821", "l": "Blood Platelets", "d": [], "t": []}, {"i": "NCIT:C12520", "l": "Platelet", "d": ["An irregular, disc-shaped element in the blood that assists in blood clotting. Platelets are not blood cells, they are fragments of large bone marrow cells called megakaryocytes."], "t": []}, {"i": "MESH:D001792", "l": "Blood Platelets", "d": [], "t": []}, {"i": "SNOMEDCT:16378004", "l": "", "d": [], "t": []}], "preferred_name": "platelet", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "CL:0000940", "l": "mucosal-associated invariant T cell", "d": ["An alpha-beta T cell that is found in the lamina propria of mucosal tissues and is restricted by the MR-1 molecule. This cell develops from double-positive, alpha-beta thymocyte."], "t": []}, {"i": "UMLS:C3891065", "l": "Mucosal-Associated Invariant T-Cell", "d": [], "t": []}, {"i": "NCIT:C115217", "l": "Mucosal-Associated Invariant T-Cell", "d": ["A T-cell subtype bearing a semi-invariant T-cell receptor and restricted by the major histocompatibility complex related molecule MR1. These cells occupy peripheral tissues and are noted for their reactivity against various microorganisms of either bacterial or fungal origin."], "t": []}, {"i": "MESH:D000072336", "l": "Mucosal-Associated Invariant T Cells", "d": [], "t": []}], "preferred_name": "mucosal-associated invariant T cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:2000081", "l": "melanocyte of skin of face", "d": ["Any melanocyte of skin that is part of a skin of face."], "t": []}], "preferred_name": "melanocyte of skin of face", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5908980", "l": "Plixacabtagene Autoleucel", "d": [], "t": []}, {"i": "NCIT:C203091", "l": "Plixacabtagene Autoleucel", "d": [], "t": []}], "preferred_name": "Plixacabtagene Autoleucel", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5157453", "l": "CD3+CD62L+ cells | Blood | Cell markers", "d": [], "t": []}], "preferred_name": "CD3+CD62L+ cells | Blood | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C2340022", "l": "Resting histiocyte", "d": [], "t": []}], "preferred_name": "Resting histiocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:1001100", "l": "kidney efferent arteriole smooth muscle cell", "d": ["Any smooth muscle cell that is part of some renal efferent arteriole."], "t": []}], "preferred_name": "kidney efferent arteriole smooth muscle cell", "taxa": []}
{"type": "biolink:Cell", "ic": 65.31289840569757, "identifiers": [{"i": "UMLS:C1514071", "l": "Malignant Primitive Germ Cell", "d": [], "t": []}, {"i": "NCIT:C36897", "l": "Malignant Primitive Germ Cell", "d": [], "t": []}], "preferred_name": "Malignant Primitive Germ Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "UMLS:C5446656", "l": "Tall Columnar Adenocarcinoma Cell with Reversed Polarity", "d": [], "t": []}, {"i": "NCIT:C175606", "l": "Tall Columnar Adenocarcinoma Cell with Reversed Polarity", "d": ["A tall columnar adenocarcinoma cell with its nucleus located at the apical pole of the cell rather than the basal pole."], "t": []}], "preferred_name": "Tall Columnar Adenocarcinoma Cell with Reversed Polarity", "taxa": []}
{"type": "biolink:Cell", "ic": 71.39747969210477, "identifiers": [{"i": "CL:0000114", "l": "surface ectodermal cell", "d": ["An ectodermal cell that is part of the external ectoderm, forming the outermost layer of the developing embryo. It is characterized by its polarized nature, with distinct apical and basal surfaces (Ferrante Jr., Reinke, & Stanley, 1995). Surface ectodermal cell gives rise to the epidermis, hair follicles, nails, sensory organs, and specialized structures like the apical ectodermal ridge crucial for limb development (Skoufa et al., 2024)."], "t": []}, {"i": "UMLS:C1183497", "l": "Cell of surface ectoderm", "d": [], "t": []}], "preferred_name": "surface ectodermal cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4695105", "l": "Kymriah (DLBCL)", "d": [], "t": []}], "preferred_name": "Kymriah (DLBCL)", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5704896", "l": "Skysona", "d": [], "t": []}], "preferred_name": "Skysona", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5157379", "l": "CD20 cells | Blood | Cell markers", "d": [], "t": []}], "preferred_name": "CD20 cells | Blood | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1440360", "l": "CD82+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:1372936005", "l": "", "d": [], "t": []}], "preferred_name": "CD82+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4307063", "l": "Tanycyte NN_1 Cnmd tanycyte of subfornical organ (Mmus)", "d": ["A tanycyte of subfornical organ of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Cnmd (Mmus), Sfta3-ps (Mmus). It is distinguished from other Tanycyte NN_1 cells by expression of Cnmd. These cells are located in the brain , in or close to the regions: choroid plexus, third ventricle . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5243 Tanycyte NN_1."], "t": []}], "preferred_name": "Tanycyte NN_1 Cnmd tanycyte of subfornical organ (Mmus)", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4079006", "l": "cervical dorsal root ganglion RET neuron", "d": ["A non-peptidergic nociceptor whose soma is located in the cervical dorsal root ganglion and that expresses the receptor tyrosine kinase RET (encoded by RET). This neuron is distinguished from peptidergic nociceptors by its dependence on glial cell-derived neurotrophic factor family ligands rather than nerve growth factor, and in rodents it characteristically binds isolectin B4. In human DRG, RET-immunoreactive neurons constitute approximately 46% of TrkA-positive neurons, a significantly higher proportion than the 23% observed in mouse (Rostock et al. 2018, PMID:29229553), indicating an expanded non-peptidergic nociceptor compartment in humans."], "t": []}], "preferred_name": "cervical dorsal root ganglion RET neuron", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5163442", "l": "Eosinophils | Pericardial fluid | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Eosinophils | Pericardial fluid | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "CL:0002406", "l": "immature Vgamma2-positive thymocyte", "d": ["A double negative post-natal thymocyte that has a T cell receptor consisting of a gamma chain containing a Vgamma2 segment, and a delta chain. This cell type is CD4-negative, CD8-negative and CD24-positive."], "t": []}], "preferred_name": "immature Vgamma2-positive thymocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4030032", "l": "valve interstitial cell", "d": ["An interstitial cell that is part of a cardiac valve leaflet. Along with valve endothelial cells, a valve interstitial cell maintains tissue homeostasis for the function of cardiac valves through secreting biochemical signals, matrix proteins and matrix remodeling enzymes."], "t": []}], "preferred_name": "valve interstitial cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0487770", "l": "CD16+CD57- lymphocyte", "d": [], "t": []}], "preferred_name": "CD16+CD57- lymphocyte", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5977982", "l": "Mononuclear cells | Blood | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Mononuclear cells | Blood | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C3176907", "l": "Cytoplasmic CD79a+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:1373306003", "l": "", "d": [], "t": []}], "preferred_name": "Cytoplasmic CD79a+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "CL:0000571", "l": "leucophore", "d": ["A pigment cell derived from the neural crest. Contains uric acid or other purine crystals deposited in stacks called leucosomes. The crystals reflect light and this gives a white appearance under white light."], "t": []}], "preferred_name": "leucophore", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1522072", "l": "Mouse Keratinocyte", "d": [], "t": []}, {"i": "NCIT:C22542", "l": "Mouse Keratinocyte", "d": [], "t": []}], "preferred_name": "Mouse Keratinocyte", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4317150", "l": "Vacuolated lymphocyte", "d": [], "t": []}, {"i": "SNOMEDCT:725384001", "l": "", "d": [], "t": []}], "preferred_name": "Vacuolated lymphocyte", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1267983", "l": "Lymphocyte positive for CD96 antigen", "d": [], "t": []}, {"i": "SNOMEDCT:117423000", "l": "", "d": [], "t": []}], "preferred_name": "Lymphocyte positive for CD96 antigen", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C4086555", "l": "M2 Macrophage", "d": [], "t": []}, {"i": "NCIT:C123783", "l": "M2 Macrophage", "d": ["A macrophage that produces high levels of interleukin (IL)-10, TGF-beta and low levels of IL-12 and converts arginine to ornithine. These cells may both encourage tissue repair and inhibit inflammation."], "t": []}], "preferred_name": "M2 Macrophage", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0920751", "l": "Heart cell", "d": [], "t": []}], "preferred_name": "Heart cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4304486", "l": "Population of all nonhematic cells in portion of fluid", "d": [], "t": []}, {"i": "SNOMEDCT:719702007", "l": "", "d": [], "t": []}], "preferred_name": "Population of all nonhematic cells in portion of fluid", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C4733644", "l": "Autologous Anti-CD19 CAR T-cells IM19", "d": [], "t": []}, {"i": "NCIT:C155888", "l": "Autologous Anti-CD19 CAR T-cells IM19", "d": ["A preparation of autologous T-lymphocytes that have been genetically modified and transduced with a lentiviral vector expressing a chimeric antigen receptor (CAR) targeting the tumor-associated antigen (TAA) CD19 and containing, as of yet undisclosed co-stimulatory signaling domains, with potential immunostimulating and antineoplastic activities. Upon administration, autologous anti-CD19 CAR T-cells IM19 target and bind to CD19-expressing tumor cells, thereby inducing selective toxicity in CD19-expressing tumor cells. CD19 antigen is a B-cell specific cell surface antigen expressed in all B-cell lineage malignancies."], "t": []}], "preferred_name": "Autologous Anti-CD19 CAR T-cells IM19", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5420310", "l": "Autologous Anti-CD19 CAR T-cells 19(T2)28z1xx", "d": [], "t": []}, {"i": "NCIT:C173622", "l": "Autologous Anti-CD19 CAR T-cells 19(T2)28z1xx", "d": ["A preparation of autologous T-lymphocytes that have been genetically modified to express a chimeric antigen receptor (CAR) targeting the tumor-associated antigen (TAA) CD19, and linked to the co-stimulatory intracellular signaling domains of CD28 and the zeta chain of the TCR/CD3 complex (CD3-zeta) (CD28zeta; CD28z), with potential immunostimulating and antineoplastic activities. Upon administration, the autologous anti-CD19 CAR T-cells 19(T2)28z1xx specifically recognize and bind to CD19-expressing tumor cells, resulting in specific T-cell-mediated tumor cell lysis. CD19 antigen is a B-cell specific cell surface antigen, which is expressed in all B-cell lineage malignancies and normal B-cells. CD28 and CD3zeta provide co-stimulatory activity and may enhance the cytotoxic effect and anti-tumor activity of the CAR T-cells. The 19(T2)28z1xx CAR T-cells include a 1928zeta mutant, 1xx, which contains one instead of all three immunoreceptor tyrosine-based activation motifs (iTAMs). This may help prevent counterproductive T-cell differentiation and exhaustion."], "t": []}], "preferred_name": "Autologous Anti-CD19 CAR T-cells 19(T2)28z1xx", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "CL:0011022", "l": "fibroblast of skin of back", "d": ["A fibroblast that is part of skin of back."], "t": []}], "preferred_name": "fibroblast of skin of back", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "UMLS:C1880084", "l": "Ciliated Adenocarcinoma Cell", "d": [], "t": []}, {"i": "NCIT:C61577", "l": "Ciliated Adenocarcinoma Cell", "d": [], "t": []}], "preferred_name": "Ciliated Adenocarcinoma Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5706421", "l": "Autologous PD-1-knockout Tumor-infiltrating Lymphocytes IOV-4001", "d": [], "t": []}, {"i": "NCIT:C187652", "l": "Autologous PD-1-knockout Tumor-infiltrating Lymphocytes IOV-4001", "d": ["A preparation of autologous tumor-infiltrating lymphocytes (TILs) where the programmed cell death protein 1 (PD-1; PDCD1; CD279; programmed death-1) gene has been disrupted using transcription activator-like effector nuclease (TALEN), with potential immunomodulating and antineoplastic activities. The autologous TILs are isolated from an autologous tumor sample, expanded ex-vivo and genetically modified to inactivate PD-1. Upon administration, the autologous PD-1-knockout TILs IOV-4001 induce a T-cell-mediated immune response against tumor cells. Expression of PD-1, an inhibitory receptor expressed on activated T-cells, plays a key role in cytotoxic T-lymphocyte (CTL) suppression, T-cell exhaustion and CTL apoptosis. PD-1 knockout may abrogate T-cell exhaustion and increase T-cell activity and cytotoxicity."], "t": []}], "preferred_name": "Autologous PD-1-knockout Tumor-infiltrating Lymphocytes IOV-4001", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4307065", "l": "Tanycyte NN_2 Mylk3 alpha1-tanycyte (Mmus)", "d": ["A alpha1-tanycyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Dynlrb2 (Mmus), Mylk3 (Mmus), Sfta3-ps (Mmus). It is distinguished from other Tanycyte NN_2 cells by expression of Mylk3. It is glutamatergic. These cells are located in the Hypothalamus , in or close to the regions: Periventricular hypothalamic nucleus, intermediate part . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5245 Tanycyte NN_2.", "A alpha1-tanycyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Dynlrb2 (Mmus), Mylk3 (Mmus), Sfta3-ps (Mmus). It is distinguished from other Tanycyte NN_2 cells by expression of Mylk3. It is glutamatergic (inferred from expression of Slc17a8). These cells are located in the Hypothalamus , in or close to the regions: Periventricular hypothalamic nucleus, intermediate part . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5245 Tanycyte NN_2."], "t": []}], "preferred_name": "Tanycyte NN_2 Mylk3 alpha1-tanycyte (Mmus)", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5175005", "l": "Normoblasts | Blood cord | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Normoblasts | Blood cord | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": 90.871710685482, "identifiers": [{"i": "CL:4040003", "l": "fetal pre-type II pulmonary alveolar epithelial cell", "d": ["Precursor of type II pneumocyte. These cells do not have lamellar bodies, which are a marker of type II pneumocyte maturity."], "t": []}], "preferred_name": "fetal pre-type II pulmonary alveolar epithelial cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5571713", "l": "Transitional cells.deep|Urine/Urine sed", "d": [], "t": []}], "preferred_name": "Transitional cells.deep|Urine/Urine sed", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5216224", "l": "Leukocytes other|NCnc|Pt|Bld", "d": [], "t": []}], "preferred_name": "Leukocytes other|NCnc|Pt|Bld", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5690883", "l": "Tumor-Infiltrating B Cells", "d": [], "t": []}], "preferred_name": "Tumor-Infiltrating B Cells", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "CL:0000626", "l": "olfactory granule cell", "d": ["A granule cell that has a soma located in an olfactory bulb granule cell layer. An olfactory granule cell is an interneuron that lacks an axon, makes reciprocal dendro-dendritic synapses with mitral cells and tufted cells and is involved in the fine spatio-temporal tuning of the responses of these principal olfactory bulb neurons to odors."], "t": []}], "preferred_name": "olfactory granule cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0000886", "l": "nasal and broncial associated lymphoid tissue macrophage", "d": ["A mucosa-associated lymphoid tissue macrophage found in the nasal and bronchial mucosa-associated lymphoid tissues."], "t": []}], "preferred_name": "nasal and broncial associated lymphoid tissue macrophage", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C3661517", "l": "Neutrophil Band Cells", "d": [], "t": []}, {"i": "NCIT:C13117", "l": "Band Cell", "d": ["A late precursor of a granulocyte in which the nucleus is in the form of a curved or coiled band, not having acquired the typical multilobar shape of the mature polymorphonuclear neutrophil."], "t": []}, {"i": "SNOMEDCT:702697008", "l": "", "d": [], "t": []}], "preferred_name": "Neutrophil Band Cells", "taxa": []}
{"type": "biolink:Cell", "ic": 84.83823963392128, "identifiers": [{"i": "CL:0010008", "l": "cardiac endothelial cell", "d": ["Any endothelial cell that is part of some heart."], "t": []}], "preferred_name": "cardiac endothelial cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C3282453", "l": "human cord blood hematopoietic progenitor cell", "d": [], "t": []}], "preferred_name": "human cord blood hematopoietic progenitor cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4042015", "l": "VIP-ChAT interneuron", "d": ["A VIP GABAergic cortical interneuron expressing vasoactive intestinal polypeptide and choline acetyltransferase in the Mmus neocortex. This interneuron releases both γ-aminobutyric acid and acetylcholine."], "t": []}], "preferred_name": "VIP-ChAT interneuron", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4512352", "l": "Entire primary sclerotic mastoid cell", "d": [], "t": []}, {"i": "SNOMEDCT:727108007", "l": "", "d": [], "t": []}], "preferred_name": "Entire primary sclerotic mastoid cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5549345", "l": "FOXP3+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:1373073004", "l": "", "d": [], "t": []}], "preferred_name": "FOXP3+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C3641721", "l": "Naive T-Lymphocyte", "d": [], "t": []}, {"i": "NCIT:C104081", "l": "Naive T-Lymphocyte", "d": ["A mature T-lymphocyte that has differentiated in the bone marrow and undergone central tolerance selection in the thymus but has not interacted with its cognate antigen. These cells are characterized by the presence of the T-cell receptor, L-selectin and the IL-7 receptor and the absence of CD25, CD44, CD69 and CD45R0."], "t": []}], "preferred_name": "Naive T-Lymphocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 60.32166794997866, "identifiers": [{"i": "CL:0000015", "l": "male germ cell", "d": ["A germ cell that supports male gamete production. In some species, non-germ cells known as Sertoli cells also play a role in spermatogenesis."], "t": []}], "preferred_name": "male germ cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0003021", "l": "retinal ganglion cell C4", "d": ["A retinal ganglion cell C outer that has a medium dendritic field and a dense dendritic arbor."], "t": []}], "preferred_name": "retinal ganglion cell C4", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:1000085", "l": "stratified non keratinized epithelial stem cell", "d": [], "t": []}], "preferred_name": "stratified non keratinized epithelial stem cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1518624", "l": "Mouse Osteoblast", "d": [], "t": []}, {"i": "NCIT:C22680", "l": "Mouse Osteoblast", "d": [], "t": []}], "preferred_name": "Mouse Osteoblast", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5171965", "l": "Malignant cells | Synovial fluid | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Malignant cells | Synovial fluid | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5706526", "l": "Autologous CAR T-Cells RD14-01", "d": [], "t": []}, {"i": "NCIT:C189050", "l": "Autologous Anti-ROR1 CAR T-Cells RD14-01", "d": ["A preparation of autologous T-lymphocytes genetically modified to express a chimeric antigen receptor (CAR) targeting the tumor-associated antigen (TAA) receptor tyrosine kinase-like orphan receptor 1 (ROR1), with potential immunomodulatory and antineoplastic activities. Upon administration, the autologous anti-ROR1 CAR T-cells RD14-01 are directed to, bind to, and induce selective toxicity in tumor cells expressing ROR1. ROR1, also known as neurotrophic tyrosine kinase, receptor-related 1 (NTRKR1), is expressed during embryogenesis and in various hematological and solid malignancies. It plays key roles in tumor cell proliferation and survival."], "t": []}], "preferred_name": "Autologous CAR T-Cells RD14-01", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5856327", "l": "Allogeneic Human Cord Blood-derived Hematopoietic Progenitor Cells", "d": [], "t": []}], "preferred_name": "Allogeneic Human Cord Blood-derived Hematopoietic Progenitor Cells", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0003015", "l": "G11-ON retinal ganglion cell", "d": ["A G11 retinal ganglion cell that has post synaptic terminals in sublaminar layer S4 and is depolarized by illumination of its receptive field center."], "t": []}], "preferred_name": "G11-ON retinal ganglion cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1440320", "l": "CD48+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:1372896009", "l": "", "d": [], "t": []}], "preferred_name": "CD48+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": 64.0504372605254, "identifiers": [{"i": "CL:0000287", "l": "eye photoreceptor cell", "d": ["Any photoreceptor cell that is part of some eye."], "t": []}], "preferred_name": "eye photoreceptor cell", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "CL:0000574", "l": "erythrophore", "d": ["A pigment cell derived from the neural crest. Contains pteridine and/or carotenoid pigments in structures called pterinosomes or erythrosomes. This gives an orange to red appearance."], "t": []}], "preferred_name": "erythrophore", "taxa": []}
{"type": "biolink:Cell", "ic": 69.61095963409787, "identifiers": [{"i": "CL:0009001", "l": "compound eye retinal cell", "d": ["Any cell in the compound eye, a light sensing organ composed of ommatidia."], "t": []}], "preferred_name": "compound eye retinal cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1512639", "l": "Immature Platelet", "d": [], "t": []}, {"i": "NCIT:C13126", "l": "Immature Platelet", "d": ["A young platelet that contains residual mRNA and rRNA when released from the bone marrow into the peripheral circulation as a result of thrombopoiesis. Immature platelets normally make up a small percentage of the total circulating platelets (1.1-6.1%, with a mean of 3.4%.). An increased proportion of immature platelets in blood indicates increased thrombopoiesis. The relationship between the percent of immature platelets and the platelet count can be used to determine the rate of platelet turnover."], "t": []}], "preferred_name": "Immature Platelet", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5157390", "l": "CD21 cells | Blood | Cell markers", "d": [], "t": []}], "preferred_name": "CD21 cells | Blood | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5667017", "l": "Anti-Claudin18.2 CAR T Cells IBI345", "d": [], "t": []}, {"i": "NCIT:C185607", "l": "Anti-Claudin18.2 CAR T Cells IBI345", "d": ["A preparation of T-lymphocytes engineered to express a chimeric antigen receptor (CAR) specific for the tumor-associated antigen (TAA) Claudin18.2 (CLDN18.2; A2 isoform of claudin-18), with potential immunostimulating and antineoplastic activities. Upon administration, anti-CLDN18.2 CAR T cells IBI345 specifically recognize and induce selective toxicity in CLDN18.2-expressing tumor cells. CLDN18.2, a tight junction protein, is expressed on a variety of tumor cells, but its expression in healthy tissues is strictly confined to short-lived differentiated epithelial cells of the gastric mucosa."], "t": []}], "preferred_name": "Anti-Claudin18.2 CAR T Cells IBI345", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5157320", "l": "CD15 cells | Blood | Cell markers", "d": [], "t": []}], "preferred_name": "CD15 cells | Blood | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": 84.21065366064373, "identifiers": [{"i": "UMLS:C1881535", "l": "Malignant Apocrine Cell", "d": [], "t": []}, {"i": "NCIT:C62500", "l": "Malignant Apocrine Cell", "d": [], "t": []}], "preferred_name": "Malignant Apocrine Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 83.63771255585968, "identifiers": [{"i": "UMLS:C1515965", "l": "Anaplastic Large B-Lymphocyte", "d": [], "t": []}, {"i": "NCIT:C37015", "l": "Anaplastic Large B-Lymphocyte", "d": [], "t": []}], "preferred_name": "Anaplastic Large B-Lymphocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 84.83823963392128, "identifiers": [{"i": "CL:0000958", "l": "T1 B cell", "d": ["A transitional stage B cell that migrates from the bone marrow into the peripheral circulation, and finally to the spleen. This cell type has the phenotype surface IgM-positive, surface IgD-negative, CD21-negative, CD23-negative, and CD62L-negative, and CD93-positive. This cell type has also been described as IgM-high, CD19-positive, B220-positive, AA4-positive, and CD23-negative."], "t": []}], "preferred_name": "T1 B cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0882908", "l": "CD61+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:116829001", "l": "", "d": [], "t": []}], "preferred_name": "CD61+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5575455", "l": "Autologous Anti-GPC3 CAR-IL-15-iCasp9-expressing T-lymphocytes", "d": [], "t": []}, {"i": "NCIT:C185429", "l": "Autologous Interleukin-15-armored Anti-glypican-3 CAR-iC9-expressing T-lymphocytes", "d": ["A preparation of T-lymphocytes that have been genetically modified to express a chimeric antigen receptor (CAR) specific for glypican-3 (GPC3) and express interleukin-15 (IL-15) and the suicide gene, inducible caspase 9 (iCasp9 or iC9), with potential immunostimulating and antineoplastic activities. Upon administration, autologous IL-15-armored anti-GPC3 CAR-iC9-expressing T-lymphocytes specifically target and bind to GPC3-expressing tumor cells, resulting in tumor cell lysis. GPC3, a heparan sulfate proteoglycan and a member of the glypican family, is overexpressed on certain tumor cell types while minimally expressed on normal, healthy cells; GPC3 plays an important role in cellular proliferation and differentiation. IL-15 is a pro-survival cytokine that potentiates, in addition to promoting T-cell proliferation and persistence, the immune response against tumor cells. The iCasp9 safety switch consists of a full-length caspase 9, including its caspase recruitment domain, linked to a human FK506 drug-binding domain with an F36V mutation (FKBP12-F36V). If the administered CAR T-cells lead to unacceptable side effects, the chemical homodimerizer AP1903 can be administered. AP1903 binds to the FKBP12-F36V drug-binding domain, activates caspase 9 and results in apoptosis of the administered CAR T-cells."], "t": []}], "preferred_name": "Autologous Anti-GPC3 CAR-IL-15-iCasp9-expressing T-lymphocytes", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "CL:0002662", "l": "luminal cell of lactiferous duct", "d": ["A luminal epithelial cell of the lactiferous duct. This cuboidal epithelial cell expresses keratin-18 and is estrogen-receptor alpha positive."], "t": []}, {"i": "UMLS:C1184142", "l": "Luminal cell of lactiferous duct", "d": [], "t": []}], "preferred_name": "luminal cell of lactiferous duct", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0230521", "l": "Mitotic cell in anaphase", "d": [], "t": []}, {"i": "SNOMEDCT:7566005", "l": "", "d": [], "t": []}], "preferred_name": "Mitotic cell in anaphase", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "CL:1000182", "l": "malpighian tubule tip cell", "d": ["Any tip cell that is part of some Malpighian tubule."], "t": []}], "preferred_name": "malpighian tubule tip cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5171668", "l": "Lymphocytes | Synovial fluid | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Lymphocytes | Synovial fluid | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5670722", "l": "Anti-CD19/CD20/CD22 CAR T-Cells", "d": [], "t": []}, {"i": "NCIT:C186728", "l": "Anti-CD19/CD20/CD22 CAR T-Cells", "d": ["A preparation of human T-lymphocytes engineered to express a chimeric antigen receptor (CAR) specific for the tumor-associated antigens (TAAs) cluster of differentiation 19 (CD19), CD20 and CD22, with potential immunostimulating and antineoplastic activities. Upon administration, the anti-CD19/CD20/CD22 CAR-T cells target and bind to CD19, CD20 and CD22 expressed on the surface of certain tumor cells. This induces selective toxicity in tumor cells expressing these TAAs. The TAAs are overexpressed in certain hematologic malignancies."], "t": []}], "preferred_name": "Anti-CD19/CD20/CD22 CAR T-Cells", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5853580", "l": "ISP 001", "d": [], "t": []}], "preferred_name": "ISP 001", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5220579", "l": "Erythrocyte clumps|Urine/Urine sed", "d": [], "t": []}], "preferred_name": "Erythrocyte clumps|Urine/Urine sed", "taxa": []}
{"type": "biolink:Cell", "ic": 53.97147567732198, "identifiers": [{"i": "CL:0000468", "l": "neuroglioblast (sensu Nematoda and Protostomia)", "d": ["A precursor of the central nervous system that gives rise to both neurons and glial cells."], "t": []}], "preferred_name": "neuroglioblast (sensu Nematoda and Protostomia)", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C4687728", "l": "Allogeneic Double Negative T Cells", "d": [], "t": []}, {"i": "NCIT:C147134", "l": "Allogeneic Double Negative T Cells", "d": ["A population of healthy, donor-derived CD4 and CD8 double-negative T-lymphocytes (DNTs), with potential immunomodulating and anti-leukemic activities. The DNTs are expanded ex vivo in order to enhance their tumor destroying potential. Upon administration of the allogeneic DNTs (DNT-UHN-1), the receptors NKG2-D type II integral membrane protein (KLRK1; NKG2D) and  DNAX accessory molecule 1 (cluster of differentiation 226; CD226; DNAM-1) expressed on the DNTs recognize and bind to their cognate ligands expressed on leukemia cells. Upon binding, the DNTs release interferon-gamma (IFN-g), thereby destroying the tumor cells. DNTs derived from peripheral blood of healthy donors appear to be effective against certain types of tumor cells, including leukemia cells, and do not attack normal hematopoietic cells. NKG2D, a member of the CD94/NKG2 family of C-type lectin-like receptors, and DNAM-1, a member of the immunoglobulin superfamily containing 2 Ig-like domains of the V-set, play a key role in natural killer cell (NK)-mediated tumor cell killing. Certain tumor cells express higher levels of NKG2D and DNAM-1 ligands on their surfaces, thereby increasing their susceptibility to DNT-mediated cell lysis."], "t": []}], "preferred_name": "Allogeneic Double Negative T Cells", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0000246", "l": "Mauthner neuron", "d": [], "t": []}], "preferred_name": "Mauthner neuron", "taxa": []}
{"type": "biolink:Cell", "ic": 87.18682603146104, "identifiers": [{"i": "UMLS:C1707838", "l": "EBV-Transformed Late Germinal Center/Post-Germinal Center B-Lymphocyte", "d": [], "t": []}, {"i": "NCIT:C45694", "l": "EBV-Transformed Late Germinal Center/Post-Germinal Center B-Lymphocyte", "d": ["A B-lymphocyte that has been activated to be receptive to Epstein Barr virus and is found in the area of a lymph nodule containing aggregations of actively proliferating lymphocytes."], "t": []}], "preferred_name": "EBV-Transformed Late Germinal Center/Post-Germinal Center B-Lymphocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 65.45008396901423, "identifiers": [{"i": "CL:0000891", "l": "foam cell", "d": ["A type of cell containing lipids in small vacuoles and typically seen in atherolosclerotic lesions, as well as other conditions."], "t": []}], "preferred_name": "foam cell", "taxa": []}
{"type": "biolink:Cell", "ic": 86.30756602822301, "identifiers": [{"i": "CL:4023028", "l": "L5 non-Martinotti sst GABAergic interneuron (Mmus)", "d": ["A sst GABAergic cortical interneuron with a soma found in lower L5 with mostly local axonal arborization but with some sparse ascending axons. L5 non-Martinotti sst cells show somatic localization and local axon plexus in L5b and L5b/6 and substantial innervation of L3 and L4, and receive thalamic input from the ventral posteromedial nucleus and specifically target L4 neurons, avoiding L5 pyramidal cells. L5 non-Martinotti sst cells tend to show a higher input resistance and seem to be less stuttering."], "t": []}], "preferred_name": "L5 non-Martinotti sst GABAergic interneuron (Mmus)", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C6021831", "l": "Blasts.CD45+", "d": [], "t": []}], "preferred_name": "Blasts.CD45+", "taxa": []}
{"type": "biolink:Cell", "ic": 89.40238429118027, "identifiers": [{"i": "CL:0000562", "l": "nucleate erythrocyte", "d": ["An erythrocyte having a nucleus."], "t": []}], "preferred_name": "nucleate erythrocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5417809", "l": "Autologous Anti-BCMA-CAR-4-1BB-CD3zeta-expressing T-cells C-CAR088", "d": [], "t": []}, {"i": "NCIT:C170747", "l": "Autologous Anti-BCMA-CAR-4-1BB-CD3zeta-expressing T-cells C-CAR088", "d": ["A preparation of autologous T-lymphocytes that have been transduced with a vector expressing a chimeric antigen receptor (CAR) containing a single chain variable fragment (scFv) specific for the epitome cluster E3 in the extracellular domain (ECD) of the tumor-associated antigen (TAA) B-cell maturation antigen (BCMA; tumor necrosis factor receptor superfamily member 17; TNFRSF17) that is fused to the co-stimulatory domain of 4-1BB (CD137) and the T-cell receptor signaling domain of CD3zeta (CD3z), with potential immunostimulating and antineoplastic activities. Upon administration, the autologous anti-BCMA-CAR-4-1BB-CD3zeta-expressing T-cells C-CAR088 specifically recognize and induce selective toxicity in BCMA-expressing tumor cells. BCMA, a tumor-specific antigen and a receptor for both a proliferation-inducing ligand (APRIL) and B-cell activating factor (BAFF), is a member of the tumor necrosis factor receptor superfamily (TNFRSF) and plays a key role in the survival of B-lymphocytes and plasma cells. BCMA is found on the surfaces of B-cells and is overexpressed on malignant plasma cells."], "t": []}], "preferred_name": "Autologous Anti-BCMA-CAR-4-1BB-CD3zeta-expressing T-cells C-CAR088", "taxa": []}
{"type": "biolink:Cell", "ic": 74.50942324134168, "identifiers": [{"i": "CL:4042028", "l": "immature neuron", "d": ["A neuron in the central nervous system that is not committed to a differentiated fate, has not been newly derived from neurogenesis, and does not integrate into any circuit."], "t": []}], "preferred_name": "immature neuron", "taxa": []}
{"type": "biolink:Cell", "ic": 80.96785908349635, "identifiers": [{"i": "CL:0005020", "l": "lymphangioblast", "d": ["Lymphatic progenitor cells."], "t": []}], "preferred_name": "lymphangioblast", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5380986", "l": "Cells.CD8.CMV specific.CMV antigen stimulated CD107a+b expressing", "d": [], "t": []}], "preferred_name": "Cells.CD8.CMV specific.CMV antigen stimulated CD107a+b expressing", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5417959", "l": "CTX130", "d": [], "t": []}, {"i": "NCIT:C173153", "l": "Allogeneic CRISPR-Cas9 Engineered Anti-CD70 CAR-T Cells CTX130", "d": ["A preparation of human allogeneic T-lymphocytes gene-edited with the clustered regularly interspaced short palindromic repeats (CRISPR)-Cas9 nuclease complex to disrupt expression of endogenous TCR and major histocompatibility complex (MHC) class I molecules and modified to express a chimeric antigen receptor (CAR) specific for the tumor-associated antigen (TAA) human cluster of differentiation 70 (CD70), with potential immunostimulating and antineoplastic activities. Upon introduction into the patient, the allogeneic CRISPR-Cas9 engineered anti-CD70 CAR T-cells CTX130 recognize and bind to CD70-overexpressing tumor cells. This may result in a specific cytotoxic T-lymphocyte (CTL)-mediated killing of CD70-positive tumor cells. CD70, the ligand for the costimulatory receptor CD27 and a member of the tumor necrosis factor (TNF) family, is found on the surfaces of various types of cancer cells. Disruption of endogenous TCR prevents graft-versus-host disease (GvHD); the disruption of MHC class I molecules increases the persistence of the CAR T-cells."], "t": []}], "preferred_name": "CTX130", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1440248", "l": "CD11c+CD25+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:1372965004", "l": "", "d": [], "t": []}], "preferred_name": "CD11c+CD25+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1717693", "l": "Chronic leukemia markers", "d": [], "t": []}], "preferred_name": "Chronic leukemia markers", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0230522", "l": "Mitotic cell in telophase", "d": [], "t": []}, {"i": "SNOMEDCT:31443005", "l": "", "d": [], "t": []}], "preferred_name": "Mitotic cell in telophase", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C3178786", "l": "Noradrenergic Neurons", "d": [], "t": []}], "preferred_name": "Noradrenergic Neurons", "taxa": []}
{"type": "biolink:Cell", "ic": 53.24324153491741, "identifiers": [{"i": "CL:0000647", "l": "multinucleated giant cell", "d": ["A phagocytic syncytial cell formed by the fusion of macrophages, occurs in chronic inflammatory responses to persistent microorganism such as M.tuberculosis, component of granulomas. Sometimes used to refer to megakaryocytes."], "t": []}, {"i": "UMLS:C0017526", "l": "Giant Cells", "d": [], "t": []}, {"i": "NCIT:C12607", "l": "Giant Cell", "d": ["An abnormally large cell that contains multiple nuclei and an abundant amount of cytoplasm."], "t": []}, {"i": "MESH:D015726", "l": "Giant Cells", "d": [], "t": []}, {"i": "SNOMEDCT:60401004", "l": "", "d": [], "t": []}, {"i": "SNOMEDCT:81480003", "l": "", "d": [], "t": []}], "preferred_name": "multinucleated giant cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0002154", "l": "early promyelocyte", "d": ["A promyelocyte with a nucleus that is indented and contains more marginated heterochromatin compared to its precursor cell (myeloblast); cytoplasm is deeply basophilic and contains numerous mitochondria and meandering cysternae of endoplasmic reticulum; largest of the granulocyte lineages."], "t": []}, {"i": "UMLS:C2335624", "l": "Early promyelocyte", "d": [], "t": []}], "preferred_name": "early promyelocyte", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5157653", "l": "CD71 cells | Blood | Cell markers", "d": [], "t": []}], "preferred_name": "CD71 cells | Blood | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4310135", "l": "STR cholinergic-GABAergic neuron (Primate)", "d": ["A striatal cholinergic-GABAergic neuron of the Primates brain. These cells are located in the striatum . Reference transcriptomic data for this type can be found in the dataset/taxonomy - HMBA Basal Ganglia Consensus Taxonomy in cell set Group:STR Cholinergic GABA."], "t": []}], "preferred_name": "STR cholinergic-GABAergic neuron (Primate)", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1267956", "l": "Lymphocyte positive for CD63 antigen", "d": [], "t": []}, {"i": "SNOMEDCT:117397007", "l": "", "d": [], "t": []}], "preferred_name": "Lymphocyte positive for CD63 antigen", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5216322", "l": "Unidentified cells|NCnc|Pt|Pericard fld", "d": [], "t": []}], "preferred_name": "Unidentified cells|NCnc|Pt|Pericard fld", "taxa": []}
{"type": "biolink:Cell", "ic": 90.871710685482, "identifiers": [{"i": "CL:0019003", "l": "tracheobronchial goblet cell", "d": ["Any goblet cell that is part of the tracheobronchial epithelium."], "t": []}], "preferred_name": "tracheobronchial goblet cell", "taxa": []}
{"type": "biolink:Cell", "ic": 83.63771255585968, "identifiers": [{"i": "CL:0000841", "l": "mature conventional dendritic cell", "d": ["A mature cell of the conventional dendritic cell lineage, characterized by a high capacity for antigen presentation and typically found in a lymph node."], "t": []}, {"i": "UMLS:C1522445", "l": "Interdigitating Dendritic Cell", "d": [], "t": []}, {"i": "NCIT:C38336", "l": "Interdigitating Dendritic Cell", "d": ["A dendritic cell found in the paracortex that captures blood-borne antigens in peripheral tissues and transports them to the periarteriolar lymphoid sheath where initial B and T cell activation takes place. These cells play an important role in cellular immunity."], "t": []}, {"i": "SNOMEDCT:24333000", "l": "", "d": [], "t": []}], "preferred_name": "mature conventional dendritic cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5427250", "l": "Macrophages | Prostatic fluid | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Macrophages | Prostatic fluid | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0008010", "l": "cranial somatomotor neuron", "d": ["A cranial motor neuron whose soma is located in the midbrain andor hindbrain and which innervates the skeletal muscles of the eye or tongue."], "t": []}], "preferred_name": "cranial somatomotor neuron", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "UMLS:C0007658", "l": "Cementoblasts", "d": [], "t": []}, {"i": "NCIT:C32274", "l": "Cementoblast", "d": ["A large cell ranging in shape from cuboidal to squamous with a large central nucleus. The nucleus usually has a single nucleolus, which is active in the formation of cementum."], "t": []}], "preferred_name": "Cementoblasts", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5426675", "l": "Monocytes.programmed cell death ligand 1", "d": [], "t": []}], "preferred_name": "Monocytes.programmed cell death ligand 1", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0009046", "l": "T cell of medullary sinus of lymph node", "d": ["A T cell found in the lymph node medullary sinus."], "t": []}], "preferred_name": "T cell of medullary sinus of lymph node", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C4763523", "l": "Autologous CLL1-CD33 Compound CAR T Cells", "d": [], "t": []}, {"i": "NCIT:C157281", "l": "Autologous CLL1-CD33 Compound CAR T Cells", "d": ["Autologous T-lymphocytes transduced with a lentiviral vector expressing a compound chimeric antigen receptor (cCAR) containing two CARs, one specific for the CD33 antigen and one specific for the C-type-lectin-like molecule-1 (CLL1; C-type lectin domain family 12 member A; CLEC12A), with potential immunomodulating and antineoplastic activities. Upon administration, the CD33/CLL1-specific CARs lentiviral vector-transduced autologous T-lymphocytes, expressing both the anti-CD33 CAR and the anti-CLL1 CAR on their surfaces, specifically and simultaneously target and bind to CD33- and CLL1-expressing tumor cells, with their anti-CD33 CAR and their anti-CLL1 CAR, respectively. This induces selective toxicity in tumor cells that express the CD33 antigen and the CLL1 antigen. CD33 is expressed on normal non-pluripotent hematopoietic stem cells and is overexpressed on myeloid leukemia cells. CLL1, a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily, is overexpressed in leukemic stem cells (LSCs) and plays an important role in disease progression and relapse for myeloid malignancies."], "t": []}], "preferred_name": "Autologous CLL1-CD33 Compound CAR T Cells", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5419315", "l": "Evagenretcel", "d": [], "t": []}, {"i": "NCIT:C171809", "l": "Evagenretcel", "d": [], "t": []}], "preferred_name": "Evagenretcel", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "UMLS:C1519464", "l": "Spindle Cell Myoblast", "d": [], "t": []}, {"i": "NCIT:C36952", "l": "Spindle Cell Myoblast", "d": [], "t": []}], "preferred_name": "Spindle Cell Myoblast", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5669566", "l": "Tenvumestrocel", "d": [], "t": []}, {"i": "NCIT:C184827", "l": "Tenvumestrocel", "d": [], "t": []}], "preferred_name": "Tenvumestrocel", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0001046", "l": "memory CCR4-positive regulatory T cell", "d": ["A memory regulatory T cell with phenotype CD4-positive, CD25-positive, CD127lo, CCR4-positive, and CD45RO-positive."], "t": []}], "preferred_name": "memory CCR4-positive regulatory T cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0009074", "l": "medullary thymic epithelial cell type 4", "d": ["A thymic medullary epithelial cell that expresses typical tuft cell markers instead of classical mTEC or cTEC markers. This population has a bulbous-like structure."], "t": []}], "preferred_name": "medullary thymic epithelial cell type 4", "taxa": []}
{"type": "biolink:Cell", "ic": 58.078900276075245, "identifiers": [{"i": "CL:0000167", "l": "peptide hormone secreting cell", "d": ["Any secretory cell that is capable of some peptide hormone secretion."], "t": []}], "preferred_name": "peptide hormone secreting cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1301169", "l": "Pyknocyte", "d": [], "t": []}, {"i": "SNOMEDCT:397049008", "l": "", "d": [], "t": []}], "preferred_name": "Pyknocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5960198", "l": "T-cell Membrane-anchored Tumor-targeted IL-12-modified Tumor Infiltrating Lymphocytes", "d": [], "t": []}, {"i": "NCIT:C207054", "l": "T-cell Membrane-anchored Tumor-targeted IL-12-modified Tumor Infiltrating Lymphocytes", "d": ["A preparation of tumor infiltrating lymphocytes (TILs) engineered to express membrane-bound interleukin-12 (mbIL-12), with potential immunomodulating and antineoplastic activities. Upon infusion of the T-cell membrane-anchored tumor-targeted IL-12-modified TILs, the cells specifically recognize and kill the tumor cells. IL-12 expression activates the immune system by promoting the secretion of interferon-gamma (IFNg), activating natural killer cells (NKs), and inducing cytotoxic T-lymphocyte (CTL) responses, further killing tumor cells."], "t": []}], "preferred_name": "T-cell Membrane-anchored Tumor-targeted IL-12-modified Tumor Infiltrating Lymphocytes", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0002259", "l": "neuroepithelial stem cell", "d": ["The stem cell from which glial precursor cell arises from."], "t": []}, {"i": "UMLS:C1519562", "l": "Totipotent neuroepithelial stem cell", "d": [], "t": []}, {"i": "NCIT:C33796", "l": "Totipotent Neuroepithelial Stem Cell", "d": ["A relatively undifferentiated cell that retains the ability to divide into any type of nerve cell."], "t": []}], "preferred_name": "neuroepithelial stem cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C2324839", "l": "Set of cholinergic cells of diagonal gyrus [Ch3]", "d": [], "t": []}], "preferred_name": "Set of cholinergic cells of diagonal gyrus [Ch3]", "taxa": []}
{"type": "biolink:Cell", "ic": 87.18682603146104, "identifiers": [{"i": "CL:4301589", "l": "Astro-NT NN_1 astrocyte (Mmus)", "d": ["A astrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Gfap (Mmus), Lhfpl3 (Mmus), Gria1 (Mmus), Hopx (Mmus). Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Supertype:1159 Astro-NT NN_1."], "t": []}], "preferred_name": "Astro-NT NN_1 astrocyte (Mmus)", "taxa": []}
{"type": "biolink:Cell", "ic": 73.49439205968403, "identifiers": [{"i": "UMLS:C0225356", "l": "Myoepithelial cell", "d": [], "t": []}, {"i": "NCIT:C33152", "l": "Myoepithelial Cell", "d": ["A contractile cell found between the secretory cells and basement membrane of exocrine glands. Each myoepithelial cell has long cytoplasmic processes that wrap around a secretory unit. The contraction of the myoepithelial processes forces the secretory product from the secretory unit into its duct."], "t": []}, {"i": "SNOMEDCT:71343003", "l": "", "d": [], "t": []}], "preferred_name": "Myoepithelial cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5446453", "l": "Autologous BCL11A-disrupted Human Hematopoietic Stem and Progenitor Cells HIX763", "d": [], "t": []}, {"i": "NCIT:C175343", "l": "Autologous BCL11A-disrupted Human Hematopoietic Stem and Progenitor Cells HIX763", "d": ["A population of autologous human hematopoietic stem and progenitor cells (HSPCs) that are genetically modified to disrupt the activity of B-cell lymphoma/leukemia 11A (BCL11A), with potential usage for transplantation in patients with sickle cell disease (SCD). Upon infusion into the patient, the autologous BCL11A-disrupted HSPCs HIX763 can populate the bone marrow and differentiate into a variety of blood cell types including lymphoid cells, myeloid cells and erythroblasts. As BCL11A is a suppressor of fetal hemoglobin (HbF; hemoglobin F) expression, disruption of the expression of BCL11A stimulates the expression of HbF in erythrocytes that differentiate from HIX763. HbF may compensate for reduced or absent expression of adult hemoglobin (Hb) in patients with SCD. HbF is a form of the oxygen carrying Hb that is naturally present at birth and is then replaced by the adult form of hemoglobin."], "t": []}], "preferred_name": "Autologous BCL11A-disrupted Human Hematopoietic Stem and Progenitor Cells HIX763", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5163540", "l": "Epithelial cells | Semen | Fertility testing", "d": [], "t": []}], "preferred_name": "Epithelial cells | Semen | Fertility testing", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0945930", "l": "CD4+CD45RA+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:1373110007", "l": "", "d": [], "t": []}], "preferred_name": "CD4+CD45RA+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": 69.54608552448124, "identifiers": [{"i": "CL:0000670", "l": "primordial germ cell", "d": ["A primordial germ cell is a diploid germ cell precursors that transiently exist in the embryo before they enter into close association with the somatic cells of the gonad and become irreversibly committed as germ cells."], "t": []}, {"i": "UMLS:C0231044", "l": "Structure of primordial sex cell", "d": [], "t": []}, {"i": "NCIT:C33401", "l": "Primordial Germ Cell", "d": ["A mesodermal precursor of germ cells, detectable at four weeks of fetal development. It originates in the allantois and then migrates through the hindgut and into the genital ridge, where it proliferates and differentiates into an oogonia or spermatogonia cell."], "t": []}, {"i": "SNOMEDCT:23430009", "l": "", "d": [], "t": []}], "preferred_name": "primordial germ cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1182459", "l": "Differentiated muscle cell", "d": [], "t": []}], "preferred_name": "Differentiated muscle cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4510901", "l": "Blast cell positive for CD117 antigen", "d": [], "t": []}, {"i": "SNOMEDCT:724245000", "l": "", "d": [], "t": []}], "preferred_name": "Blast cell positive for CD117 antigen", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "CL:1000123", "l": "metanephric nephron tubule epithelial cell", "d": ["Any epithelial cell that is part of some metanephric nephron tubule."], "t": []}], "preferred_name": "metanephric nephron tubule epithelial cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C6021821", "l": "Cells.CD3+CD19- (T cells)", "d": [], "t": []}], "preferred_name": "Cells.CD3+CD19- (T cells)", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "CL:0002112", "l": "B220-positive CD38-negative unswitched memory B cell", "d": ["A B220-positive CD38-negative unswitched memory B cell is a CD38-negative unswitched memory B cell that has the phenotype B220-positive, CD38-negative, IgD-positive, CD138-negative, and IgG-negative."], "t": []}], "preferred_name": "B220-positive CD38-negative unswitched memory B cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4033096", "l": "diffuse bipolar 4b cell", "d": ["An ON bipolar cell that has high expression of NOS1AP compared with other bipolar cells."], "t": []}], "preferred_name": "diffuse bipolar 4b cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0009053", "l": "stromal cell of anorectum lamina propria", "d": ["A stromal cell found in the lamina propria of the anorectum."], "t": []}], "preferred_name": "stromal cell of anorectum lamina propria", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5175006", "l": "Normoblasts | Fetus | Blood | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Normoblasts | Fetus | Blood | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": 90.871710685482, "identifiers": [{"i": "CL:1000398", "l": "endothelial cell of hepatic sinusoid", "d": ["An endothelial cell that is part of the hepatic sinusoid. These cells possess flattened areas containing perforations about 0.1 micrometers in diameter, known as fenestrae. The fenestrae are arranged in groups known as sieve plates."], "t": []}, {"i": "UMLS:C1179463", "l": "Endothelial cell of hepatic sinusoid", "d": [], "t": []}], "preferred_name": "endothelial cell of hepatic sinusoid", "taxa": []}
{"type": "biolink:Cell", "ic": 81.743421370964, "identifiers": [{"i": "CL:0000467", "l": "adrenocorticotropic hormone secreting cell", "d": ["A peptide hormone secreting cell that produces adrenocorticotropin, or corticotropin."], "t": []}], "preferred_name": "adrenocorticotropic hormone secreting cell", "taxa": []}
{"type": "biolink:Cell", "ic": 70.82453858732072, "identifiers": [{"i": "UMLS:C3161470", "l": "Cartilage Cell", "d": [], "t": []}, {"i": "NCIT:C48695", "l": "Cartilage Cell", "d": [], "t": []}, {"i": "SNOMEDCT:86024004", "l": "", "d": [], "t": []}], "preferred_name": "Cartilage Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5666975", "l": "Autologous Anti-GPC3 CAR T Cells BOXR1030", "d": [], "t": []}, {"i": "NCIT:C185392", "l": "Autologous Anti-GPC3 CAR T Cells BOXR1030", "d": ["A preparation of autologous T-lymphocytes that have been genetically modified to express a chimeric antigen receptor (CAR) specific for glypican-3 (GPC3) and glutamic-oxaloacetic transaminase 2 (GOT2) transgene, with potential immunostimulating and antineoplastic activities. Upon administration, autologous anti-GPC3 CAR T cells BOXR1030 specifically targets and binds to GPC3-expressing tumor cells, resulting in tumor cell lysis. GPC3, a heparan sulfate proteoglycan and a member of the glypican family, is overexpressed on certain tumor cell types while minimally expressed on normal, healthy cells; GPC3 plays an important role in cellular proliferation and differentiation. The inclusion of GOT2, a mitochondrial enzyme that plays an important role in cellular metabolism, may improve T-cell metabolic function and anti-tumor activity."], "t": []}], "preferred_name": "Autologous Anti-GPC3 CAR T Cells BOXR1030", "taxa": []}
{"type": "biolink:Cell", "ic": 81.34422831136257, "identifiers": [{"i": "CL:4072001", "l": "newly formed oligodendrocyte", "d": ["A post-mitotic oligodendrocyte that has exited the cell cycle and begun early stage differentiation. The cell begins to acquire oligodendrocyte-like characteristics but has not yet initiated myelination. In mice, NFOL is marked by the expression of Tcf7l2 and Cemip2 (also known as Tmem2), among other early myelin-related genes. These markers highlight cells transitioning from a precursor to a more differentiated, pre-myelinating state."], "t": []}], "preferred_name": "newly formed oligodendrocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0002663", "l": "myocardial endocrine cell of atrium", "d": ["A myocardial endocrine cell that is part of the atrium."], "t": []}, {"i": "UMLS:C2336924", "l": "Myocardial endocrine cell of atrium", "d": [], "t": []}], "preferred_name": "myocardial endocrine cell of atrium", "taxa": []}
{"type": "biolink:Cell", "ic": 92.76600187037766, "identifiers": [{"i": "CL:1000465", "l": "chromaffin cell of ovary", "d": ["A chromaffin cell that is part of the ovary."], "t": []}, {"i": "UMLS:C1183980", "l": "Chromaffin cell of ovary", "d": [], "t": []}], "preferred_name": "chromaffin cell of ovary", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "CL:0002630", "l": "actinomycete-type spore", "d": ["A spore formed from bacteria in the order Actinomycetales."], "t": []}], "preferred_name": "actinomycete-type spore", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5148824", "l": "Reticulocytes.low fluorescence", "d": [], "t": []}], "preferred_name": "Reticulocytes.low fluorescence", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4240449", "l": "Vascular smooth muscle cell of peripheral artery", "d": [], "t": []}], "preferred_name": "Vascular smooth muscle cell of peripheral artery", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5963649", "l": "Deltacel", "d": [], "t": []}], "preferred_name": "Deltacel", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C2346934", "l": "Malignant Fusiform Osteoblast", "d": [], "t": []}, {"i": "NCIT:C67521", "l": "Malignant Fusiform Osteoblast", "d": [], "t": []}], "preferred_name": "Malignant Fusiform Osteoblast", "taxa": []}
{"type": "biolink:Cell", "ic": 63.80296755263789, "identifiers": [{"i": "UMLS:C1513925", "l": "Neoplastic Astrocyte", "d": [], "t": []}, {"i": "NCIT:C37127", "l": "Neoplastic Astrocyte", "d": [], "t": []}], "preferred_name": "Neoplastic Astrocyte", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5216258", "l": "Macrophages|NCnc|Pt|Synv fld", "d": [], "t": []}], "preferred_name": "Macrophages|NCnc|Pt|Synv fld", "taxa": []}
{"type": "biolink:Cell", "ic": 73.04009684703995, "identifiers": [{"i": "UMLS:C1510723", "l": "Abnormal Erythroid Precursor", "d": [], "t": []}, {"i": "NCIT:C37053", "l": "Abnormal Erythroid Precursor", "d": [], "t": []}], "preferred_name": "Abnormal Erythroid Precursor", "taxa": []}
{"type": "biolink:Cell", "ic": 90.871710685482, "identifiers": [{"i": "CL:1000370", "l": "transitional myocyte of left branch of atrioventricular bundle", "d": ["A transitional myocyte that is part of the left branch of atrioventricular bundle."], "t": []}, {"i": "UMLS:C2332614", "l": "Transitional myocyte of left branch of atrioventricular bundle", "d": [], "t": []}], "preferred_name": "transitional myocyte of left branch of atrioventricular bundle", "taxa": []}
{"type": "biolink:Cell", "ic": 79.9528279018387, "identifiers": [{"i": "UMLS:C5706882", "l": "PIT1-Lineage Adenohypophysial Cell", "d": [], "t": []}, {"i": "NCIT:C187077", "l": "PIT1-Lineage Adenohypophysial Cell", "d": ["An adenohypophysial cell determined by the expression of pituitary specific transcription factor 1."], "t": []}], "preferred_name": "PIT1-Lineage Adenohypophysial Cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1717809", "l": "Erythrocytes.CD55 & CD59", "d": [], "t": []}], "preferred_name": "Erythrocytes.CD55 & CD59", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "CL:1000487", "l": "smooth muscle cell of prostate", "d": ["A smooth muscle cell that is part of the prostate gland."], "t": []}, {"i": "UMLS:C2336187", "l": "Smooth muscle fiber of prostate", "d": [], "t": []}], "preferred_name": "smooth muscle cell of prostate", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4267783", "l": "Cells.CD4-CD8-", "d": [], "t": []}], "preferred_name": "Cells.CD4-CD8-", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C3642419", "l": "Autologous Pluripotent ALDHbr Stem Cells ALD-451", "d": [], "t": []}, {"i": "NCIT:C78466", "l": "Autologous Pluripotent ALDHbr Stem Cells ALD-451", "d": ["A specific population of autologous, pluripotent bone marrow derived cells that express high levels of the cytosolic enzyme aldehyde dehydrogenase (ALDH) with potential protective and neuro-cognition improving activity. Expression of high levels of ALDH is an indicator of the biological activity in heterogenous early stage stem cells. Upon intravenous administration, these ALDH bright cells may protect normal cells and may repair damaged cells. These cells may also protect brain cells from damage and may improve neurocognition."], "t": []}], "preferred_name": "Autologous Pluripotent ALDHbr Stem Cells ALD-451", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "CL:0010004", "l": "mononuclear cell of bone marrow", "d": ["A mononuclear cell that is part_of a bone marrow."], "t": []}], "preferred_name": "mononuclear cell of bone marrow", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4023170", "l": "trigeminal sensory neuron", "d": ["A trigeminal neuron that is responsible for sensation in the face."], "t": []}], "preferred_name": "trigeminal sensory neuron", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5157459", "l": "CD3+CD8+CD27+CD62L+ cells | Blood | Cell markers", "d": [], "t": []}], "preferred_name": "CD3+CD8+CD27+CD62L+ cells | Blood | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "CL:0009028", "l": "intestinal crypt stem cell of appendix", "d": ["An intestinal crypt stem cell that is located in the vermiform appendix. These stem cells reside at the bottom of crypts in the appendix and are highly proliferative. They either differentiate into transit amplifying cells or self-renew to form new stem cells."], "t": []}], "preferred_name": "intestinal crypt stem cell of appendix", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4033146", "l": "pterygopalatine ganglion nNOS neuron", "d": ["A parasympathetic neuron that has the soma located in the pterygopalatine ganglion and expresses the marker neuronal nitric oxide synthase 1 (nNOS)."], "t": []}], "preferred_name": "pterygopalatine ganglion nNOS neuron", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C4684956", "l": "Autologous Gamma-retroviral MSGV1 139 scFv EGFRvIII CAR Gene-modified T Cells", "d": [], "t": []}, {"i": "NCIT:C143060", "l": "Autologous Gamma-retroviral MSGV1 139 scFv EGFRvIII CAR Gene-modified T Cells", "d": ["A preparation of autologous T-lymphocytes transduced with the gamma retroviral vector MSGV1 expressing a chimeric T-cell antigen receptor (CAR) consisting of a single-chain variable fragment (scFv) from a specific antibody clone (mAb139) that targets a mutant form of epidermal growth factor receptor (EGFR) known as variant III (EGFRvIII; EGFR-vIII), with potential antineoplastic activity. Upon intratumoral administration, the gamma-retroviral MSGV1 139 scFv EGFRvIII CAR gene-modified T-cells specifically target and bind to tumor cells expressing EGFRvIII, leading to selective cytotoxicity in EGFRvIII-expressing tumor cells. EGFRvIII, a tumor-associated antigen (TAA) encoded by an in-frame deletion of exons 2-7 in the EGFR gene, is specifically overexpressed by a subset of tumor cells and is not expressed in normal, healthy cells. It plays a key role in tumor cell proliferation, tumor angiogenesis and radio- and chemoresistance."], "t": []}], "preferred_name": "Autologous Gamma-retroviral MSGV1 139 scFv EGFRvIII CAR Gene-modified T Cells", "taxa": []}
{"type": "biolink:Cell", "ic": 76.40371442623734, "identifiers": [{"i": "CL:4030067", "l": "L5/6 near-projecting glutamatergic neuron", "d": ["A near-projecting glutamatergic neuron with a soma found in cortical layer 5/6.", "A transcriptomically defined near-projecting glutamatergic neuron with a soma found in cortical layer 5/6."], "t": []}], "preferred_name": "L5/6 near-projecting glutamatergic neuron", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0009077", "l": "subcapsular thymic epithelial cell", "d": ["A thymic epithelial cell located within the subcapsular region of the thymus."], "t": []}], "preferred_name": "subcapsular thymic epithelial cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C6056164", "l": "Multipotent adult arogenitor cells", "d": [], "t": []}], "preferred_name": "Multipotent adult arogenitor cells", "taxa": []}
{"type": "biolink:Cell", "ic": 86.30756602822301, "identifiers": [{"i": "UMLS:C1513968", "l": "Neoplastic Follicular Dendritic Cell", "d": [], "t": []}, {"i": "NCIT:C36893", "l": "Neoplastic Follicular Dendritic Cell", "d": [], "t": []}], "preferred_name": "Neoplastic Follicular Dendritic Cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C3642149", "l": "Rivogenlecleucel", "d": [], "t": []}], "preferred_name": "Rivogenlecleucel", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0003013", "l": "G10 retinal ganglion cell", "d": ["A mono-stratified retinal ganglion cell that has a large dendritic field, a medium dendritic arbor, and a long secondary dendrite shaft with post synaptic terminals in sublaminar layer S4."], "t": []}], "preferred_name": "G10 retinal ganglion cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4310104", "l": "Islands of Calleja granule cell (Primate)", "d": ["A Islands of Calleja granule cell of the Primates brain. These cells are located in the striatum . Reference transcriptomic data for this type can be found in the dataset/taxonomy - HMBA Basal Ganglia Consensus Taxonomy in cell set Group:OT D1 ICj."], "t": []}], "preferred_name": "Islands of Calleja granule cell (Primate)", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5154003", "l": "B lymphocytes | Bone marrow | Cell markers", "d": [], "t": []}], "preferred_name": "B lymphocytes | Bone marrow | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": 47.449681707798185, "identifiers": [{"i": "CL:0000527", "l": "efferent neuron", "d": ["A neuron which sends impulses peripherally to activate muscles or secretory cells."], "t": []}, {"i": "UMLS:C0027884", "l": "Neurons, Efferent", "d": [], "t": []}, {"i": "NCIT:C12643", "l": "Efferent Neuron", "d": ["A neuron that sends impulses from the central nervous system to skeletal muscles, glands, and visceral organs."], "t": []}, {"i": "MESH:D009476", "l": "Neurons, Efferent", "d": [], "t": []}], "preferred_name": "efferent neuron", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1518113", "l": "MB01", "d": [], "t": []}, {"i": "NCIT:C20275", "l": "MB01", "d": ["Provider: Maria Biotech Co. Ltd. - Maria Infertility Hospital Medical Institute, Seoul, Korea. Information from provider and not independently verified by NIH: Cells are positive for cell markers Oct-4, alkaline phosphatase activity and telomerase activity; Differentiate in vitro into mature neuron, glia cells, muscle cells and beating cardiomyocytes; AFP was also detected in this cells. This cell line meets the criteria for the use of human embryonic stem cells by federally funded researchers."], "t": []}], "preferred_name": "MB01", "taxa": []}
{"type": "biolink:Cell", "ic": 78.05853671694304, "identifiers": [{"i": "UMLS:C0229659", "l": "Myelomonocyte", "d": [], "t": []}, {"i": "NCIT:C37041", "l": "Neoplastic Monocyte", "d": ["An abnormal myeloid cell that is present in the peripheral blood of patients with myelomonocytic leukemia."], "t": []}, {"i": "SNOMEDCT:41621006", "l": "", "d": [], "t": []}], "preferred_name": "Myelomonocyte", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0682698", "l": "Projection neuron", "d": [], "t": []}], "preferred_name": "Projection neuron", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4246477", "l": "Mesomesenchymal cell", "d": [], "t": []}], "preferred_name": "Mesomesenchymal cell", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "CL:0002678", "l": "memory regulatory T cell", "d": ["A CD4-positive, CD25-positive alpha-beta regulatory T cell that has encountered antigen."], "t": []}], "preferred_name": "memory regulatory T cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1267809", "l": "Lymphocyte negative for surface membrane immunoglobulin and positive for CD79 antigen", "d": [], "t": []}, {"i": "SNOMEDCT:117513006", "l": "", "d": [], "t": []}], "preferred_name": "Lymphocyte negative for surface membrane immunoglobulin and positive for CD79 antigen", "taxa": []}
{"type": "biolink:Cell", "ic": 87.18682603146104, "identifiers": [{"i": "CL:4029002", "l": "germline-derived nurse cell", "d": ["A gamete-nursing cell that derives from a germline cell (del Pino, 2021)."], "t": []}], "preferred_name": "germline-derived nurse cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:1000333", "l": "serous cell of epithelium of lobular bronchiole", "d": ["A serous secreting cell that is part of the epithelium of bronchiole."], "t": []}, {"i": "UMLS:C2325557", "l": "Serous cell of epithelium of lobular bronchiole", "d": [], "t": []}], "preferred_name": "serous cell of epithelium of lobular bronchiole", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5783692", "l": "Rilparencel", "d": [], "t": []}, {"i": "NCIT:C190422", "l": "Rilparencel", "d": [], "t": []}], "preferred_name": "Rilparencel", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1257857", "l": "COS-1 Cells", "d": [], "t": []}], "preferred_name": "COS-1 Cells", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "CL:2000056", "l": "Meynert cell", "d": ["Any pyramidal cell that is part of a regional part of cerebral cortex."], "t": []}], "preferred_name": "Meynert cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1267961", "l": "Lymphocyte positive for CD66D antigen", "d": [], "t": []}, {"i": "SNOMEDCT:117402006", "l": "", "d": [], "t": []}], "preferred_name": "Lymphocyte positive for CD66D antigen", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5157397", "l": "CD22+CD19+ | White blood cells | Cell markers", "d": [], "t": []}], "preferred_name": "CD22+CD19+ | White blood cells | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0002577", "l": "placental epithelial cell", "d": ["An epithelial cell of the placenta."], "t": []}], "preferred_name": "placental epithelial cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C4054455", "l": "Multinucleated Hepatocyte", "d": [], "t": []}, {"i": "NCIT:C120900", "l": "Multinucleated Hepatocyte", "d": ["A giant hepatocyte with multiple nuclei."], "t": []}], "preferred_name": "Multinucleated Hepatocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 59.67098798069023, "identifiers": [{"i": "UMLS:C1518178", "l": "Malignant Epithelial Small Cell", "d": [], "t": []}, {"i": "NCIT:C36795", "l": "Malignant Epithelial Small Cell", "d": ["A malignant cell of epithelial origin with a small nucleus and scant amount of cytoplasm."], "t": []}], "preferred_name": "Malignant Epithelial Small Cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5171653", "l": "Lymphocyte T-cell and B-cell and Natural killer subsets | Blood | Cell markers", "d": [], "t": []}], "preferred_name": "Lymphocyte T-cell and B-cell and Natural killer subsets | Blood | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1267673", "l": "Ovum of parasite (cell)", "d": [], "t": []}], "preferred_name": "Ovum of parasite (cell)", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C6049815", "l": "Olmocabtagene Autoleucel", "d": [], "t": []}, {"i": "NCIT:C215290", "l": "Olmocabtagene Autoleucel", "d": [], "t": []}], "preferred_name": "Olmocabtagene Autoleucel", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C3825563", "l": "Ultrastructure (Biology)", "d": [], "t": []}], "preferred_name": "Ultrastructure (Biology)", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "UMLS:C1709187", "l": "Neoplastic Osteoclast-Like Giant Cell", "d": [], "t": []}, {"i": "NCIT:C47815", "l": "Neoplastic Osteoclast-Like Giant Cell", "d": [], "t": []}], "preferred_name": "Neoplastic Osteoclast-Like Giant Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 75.70995031940328, "identifiers": [{"i": "UMLS:C1512550", "l": "Hyperchromatic Spindle Cell", "d": [], "t": []}, {"i": "NCIT:C37084", "l": "Hyperchromatic Spindle Cell", "d": [], "t": []}], "preferred_name": "Hyperchromatic Spindle Cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5853467", "l": "TBX-1400", "d": [], "t": []}], "preferred_name": "TBX-1400", "taxa": []}
{"type": "biolink:Cell", "ic": 89.40238429118027, "identifiers": [{"i": "CL:0001070", "l": "beige adipocyte", "d": ["An adipocyte that is beige in color, thermogenic, and which differentiates in white fat tissue from a Myf5-negative progenitor."], "t": []}, {"i": "UMLS:C4277680", "l": "Adipocytes, Beige", "d": [], "t": []}, {"i": "MESH:D000069797", "l": "Adipocytes, Beige", "d": [], "t": []}], "preferred_name": "beige adipocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1514276", "l": "Postradiation Dysplastic Glandular Cell", "d": [], "t": []}, {"i": "NCIT:C36805", "l": "Postradiation Dysplastic Glandular Cell", "d": [], "t": []}], "preferred_name": "Postradiation Dysplastic Glandular Cell", "taxa": []}
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{"type": "biolink:Cell", "ic": 89.40238429118027, "identifiers": [{"i": "CL:0010020", "l": "cardiac glial cell", "d": ["Any glial cell that is part of some heart."], "t": []}], "preferred_name": "cardiac glial cell", "taxa": []}
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{"type": "biolink:Cell", "ic": 81.34422831136257, "identifiers": [{"i": "UMLS:C1514171", "l": "Pleomorphic Connective and Soft Tissue Cell", "d": [], "t": []}, {"i": "NCIT:C37112", "l": "Pleomorphic Connective and Soft Tissue Cell", "d": [], "t": []}], "preferred_name": "Pleomorphic Connective and Soft Tissue Cell", "taxa": []}
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{"type": "biolink:Cell", "ic": 71.22863277767533, "identifiers": [{"i": "UMLS:C1518229", "l": "Malignant Osteoblast", "d": [], "t": []}, {"i": "NCIT:C36901", "l": "Malignant Osteoblast", "d": [], "t": []}], "preferred_name": "Malignant Osteoblast", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C3495384", "l": "A16 cell group", "d": [], "t": []}], "preferred_name": "A16 cell group", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1148320", "l": "CD11c-CD20+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:1373164005", "l": "", "d": [], "t": []}], "preferred_name": "CD11c-CD20+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C6052570", "l": "Autologous IL-2-expressing Anti-mesothelin CAR T-cells OPB-101", "d": [], "t": []}, {"i": "NCIT:C219516", "l": "Autologous IL-2-expressing Anti-mesothelin CAR T-cells OPB-101", "d": ["A preparation of autologous T-lymphocytes that have been genetically modified to express a chimeric antigen receptor (CAR) specific for the human tumor-associated antigen (TAA) mesothelin (MSLN) and conditionally expressing the human cytokine interleukin-2 (IL-2) and containing an epidermal growth factor receptor (EGFR) safety switch, with potential immunomodulating and antineoplastic activities. Upon administration, autologous IL-2-expressing anti-MSLN CAR T-cells OPB-101 specifically target and kill MSLN-expressing tumor cells. MSLN, a cell surface glycoprotein involved in cell adhesion, is overexpressed in a variety of tumor cell types. Expression of IL-2, under the control of an inducible \"stim-on\" promoter (OP1), is localized at the tumor site, and may specifically enhance T-cell proliferation, limit T-cell exhaustion, enhance persistence, and increase cytotoxicity of the CAR T-cells while not affecting regulatory T-cells (Tregs). Administration of cetuximab can promote elimination of the CAR-T cells by inducing an antibody dependent cellular cytotoxicity (ADCC) response."], "t": []}], "preferred_name": "Autologous IL-2-expressing Anti-mesothelin CAR T-cells OPB-101", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0009073", "l": "medullary thymic epithelial cell type 3", "d": ["A thymic medullary epithelial cell considered to be a post-AIRE cell. This group of AIRE-mTECs is heterogeneous and also includes mTECs within Hassall's Corpuscles."], "t": []}], "preferred_name": "medullary thymic epithelial cell type 3", "taxa": []}
{"type": "biolink:Cell", "ic": 90.871710685482, "identifiers": [{"i": "CL:0002353", "l": "fetal liver hematopoietic progenitor cell", "d": ["A hematopoietic stem cell that resides in the fetal liver. In mice, this cell type is first observed at E10.5. This cell type is MHC-positive, HSA-positive, AA4.1-positive, CD45-positive, Sca-1 positive, CD150-positive, CD48-negative and CD244-negative."], "t": []}], "preferred_name": "fetal liver hematopoietic progenitor cell", "taxa": []}
{"type": "biolink:Cell", "ic": 84.21065366064373, "identifiers": [{"i": "CL:0001008", "l": "Kit and Sca1-positive hematopoietic stem cell", "d": ["A hematopoietic stem cell that has plasma membrane part Kit-positive, SCA-1-positive, CD150-positive and CD34-negative."], "t": []}], "preferred_name": "Kit and Sca1-positive hematopoietic stem cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0000367", "l": "sheath cell (sensu Nematoda)", "d": [], "t": []}], "preferred_name": "sheath cell (sensu Nematoda)", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5172505", "l": "Mesothelial cells | Pericardial fluid | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Mesothelial cells | Pericardial fluid | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5448035", "l": "afamitresgene autoleucel", "d": [], "t": []}], "preferred_name": "afamitresgene autoleucel", "taxa": []}
{"type": "biolink:Cell", "ic": 80.96785908349635, "identifiers": [{"i": "CL:0000007", "l": "early embryonic cell (metazoa)", "d": ["A cell found in the embryo before the formation of all the gem layers is complete."], "t": []}], "preferred_name": "early embryonic cell (metazoa)", "taxa": []}
{"type": "biolink:Cell", "ic": 83.11065783093733, "identifiers": [{"i": "CL:0000438", "l": "luteinizing hormone secreting cell", "d": ["A peptide hormone secreting cell pituitary that produces luteinizing hormone."], "t": []}], "preferred_name": "luteinizing hormone secreting cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0002310", "l": "mammosomatotroph", "d": ["An acidophil cell of the anterior pituitary gland that produces both prolactin and growth hormone."], "t": []}, {"i": "UMLS:C2330808", "l": "Mammosomatotroph", "d": [], "t": []}], "preferred_name": "mammosomatotroph", "taxa": []}
{"type": "biolink:Cell", "ic": 54.894187526657376, "identifiers": [{"i": "UMLS:C1517736", "l": "Large Osteoclastic Giant Cell", "d": [], "t": []}, {"i": "NCIT:C36818", "l": "Large Osteoclastic Giant Cell", "d": [], "t": []}], "preferred_name": "Large Osteoclastic Giant Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4033133", "l": "celiac ganglion SOM/CGRP neuron", "d": ["A sympathetic neuron that has the soma located in the celiac ganglion and expresses the marker somatostatin (SOM) and calcitonin gene-related peptide (CGRP)."], "t": []}], "preferred_name": "celiac ganglion SOM/CGRP neuron", "taxa": []}
{"type": "biolink:Cell", "ic": 84.83823963392128, "identifiers": [{"i": "UMLS:C1956385", "l": "Plasmacytoid Dendritic Cells", "d": [], "t": []}, {"i": "NCIT:C45236", "l": "Plasmacytoid Dendritic Cell", "d": ["A cell found in peripheral blood, lymphoid tissue, and some inflamed tissue. It produces vast amounts of type I interferons especially in response to viruses, therefore playing an important role in antiviral immunity and triggers for adaptive immune responses."], "t": []}], "preferred_name": "Plasmacytoid Dendritic Cells", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5222945", "l": "CD3- CD16+ cells/100 cells in body fluid", "d": [], "t": []}], "preferred_name": "CD3- CD16+ cells/100 cells in body fluid", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5380998", "l": "Cells.CD8.CMV specific", "d": [], "t": []}], "preferred_name": "Cells.CD8.CMV specific", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5960772", "l": "Allogeneic iPSC-derived Anti-MICA/B CAR/CD16/IL-15RF-expressing CD38-eliminated NK Cells FT536", "d": [], "t": []}, {"i": "NCIT:C207866", "l": "Allogeneic iPSC-derived Anti-MICA/B CAR/CD16/IL-15RF-expressing CD38-eliminated NK Cells FT536", "d": ["A preparation of allogeneic, off-the-shelf (OTS), natural killer (NK) cells derived from a clonal master induced pluripotent stem cell (iPSC) line, and engineered and multiplex-edited to express a chimeric antigen receptor (CAR) specific for the alpha 3 domain of the natural-killer group 2, member D receptor protein (NKG2D or KLRK1) ligands MHC class I polypeptide-related sequence A (MICA) and B (MICB), a high-affinity, non-cleavable CD16 (hnCD16) Fc receptor and a recombinant fusion of IL-15 and IL-15 receptor alpha (IL-15RF), and to eliminate CD38 expression, with potential immunostimulatory and antineoplastic activities. Upon administration, allogeneic iPSC-derived anti-MICA/B CAR/CD16/IL-15RF-expressing CD38-eliminated NK cells FT536 recognize, bind to and induce selective cytotoxicity in MICA/B-expressing tumor cells, leading to tumor cell lysis and the release of tumor neoantigens. Additionally, FT536 NK cells secrete inflammatory cytokines and chemokines, thereby enhancing T-cell activity and recruitment to the tumor site. MICA and MICB are stress-induced NKG2D ligands overexpressed on infected cells and many cancer cell types, but are not expressed on most normal, healthy cells. The shedding of the alpha 1 and alpha 2 domains of MICA and MICB from tumor cell surface allows the tumor cells to evade NKG2D-expressing immune cells, and FT536 specifically targets the alpha 3 domain of MICA/B to overcome this shedding and tumor escape mechanism. IL-15RF promotes the survival of NK cells and enhances the cytotoxic effect of the NK cells and the activated anti-tumor T-cells. When used in combination with monoclonal antibodies, the hnCD16 Fc receptor of FT536 binds to the Fc portion of tumor cell-bound monoclonal antibodies, leading to NK cell activation, cytokine secretion and enhanced antibody-dependent cellular cytotoxicity (ADCC). CD16, also known as Fc-gamma receptor III, is normally expressed on the surface of NK cells, neutrophils, monocytes and macrophages, and plays a key role in initiating ADCC. It is often downregulated in certain cancers, thereby inhibiting the anti-tumor immune response. The lack of CD38 in FT536 NK cells prevents NK cell fratricide upon co-administration with a CD38-targeting monoclonal antibody as CD38 is normally expressed on the surface of activated NK cells. This enhances ADCC mediated by CD38-targeting monoclonal antibodies."], "t": []}], "preferred_name": "Allogeneic iPSC-derived Anti-MICA/B CAR/CD16/IL-15RF-expressing CD38-eliminated NK Cells FT536", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C3686472", "l": "Biliary epithelial cell", "d": [], "t": []}], "preferred_name": "Biliary epithelial cell", "taxa": []}
{"type": "biolink:Cell", "ic": 84.21065366064373, "identifiers": [{"i": "CL:1000155", "l": "Malpighian tubule stellate cell", "d": ["A specialized epithelial secretory cell that moves chloride ions and water across the tubule epithelium."], "t": []}], "preferred_name": "Malpighian tubule stellate cell", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "CL:0020004", "l": "internal globus pallidus shell projection neuron", "d": ["A projection neuron that has its soma located in the internal segment of the globus pallidus (GPi), in the peripheral 'shell' region. In mice and primates, it expresses somatostatin and shows dual expression of GABAergic and glutamatergic markers, enabling co-release of GABA and glutamate (Wallace et al., 2017). It projects primarily to the lateral habenula (Parent & De Bellefeuille, 1982; Wallace et al., 2017), forming the limbic/aversive output stream of the GPi."], "t": []}], "preferred_name": "internal globus pallidus shell projection neuron", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5157672", "l": "CD8+CD95+ cells | Blood | Cell markers", "d": [], "t": []}], "preferred_name": "CD8+CD95+ cells | Blood | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C4055479", "l": "Allogeneic CD3- CD19- Selected Natural Killer Cells", "d": [], "t": []}, {"i": "NCIT:C121445", "l": "Allogeneic CD3- CD19- Selected Natural Killer Cells", "d": ["Human leukocyte antigen (HLA)-haploidentical donor-derived natural killer (NK) cells that are activated with the cytokine interleukin-15 (IL-15), with immunomodulating and antineoplastic activities. Upon leukapheresis, the HLA-haploidentical donor peripheral blood mononuclear cells (PBMCs) are treated to remove T-lymphocytes (CD3+) and B-lymphocytes (CD19+) cells. In turn, NK cells are expanded and activated with IL-15. Upon infusion of the allogeneic CD3- CD19- selected NK cells, these cells recognize and bind to tumor cells, and secrete perforins, granzymes, and cytokines, which results in cancer cell lysis."], "t": []}], "preferred_name": "Allogeneic CD3- CD19- Selected Natural Killer Cells", "taxa": []}
{"type": "biolink:Cell", "ic": 55.662778221241986, "identifiers": [{"i": "CL:0000188", "l": "cell of skeletal muscle", "d": ["A somatic cell located in skeletal muscle."], "t": []}], "preferred_name": "cell of skeletal muscle", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5668437", "l": "Allogeneic Anti-CD70-CAR-IL-15-transduced Cord Blood-derived Natural Killer Cells", "d": [], "t": []}, {"i": "NCIT:C183511", "l": "Allogeneic Anti-CD70-CAR-IL-15-transduced Cord Blood-derived Natural Killer Cells", "d": ["A preparation of allogeneic, umbilical cord blood (CB)-derived natural killer cells (NKs) that have been engineered to express a chimeric antigen receptor (CAR) specific for the tumor-associated antigen (TAA) human cluster of differentiation 70 (CD70) and interleukin-15 (IL-15), with potential immunostimulating and antineoplastic activities. Upon administration, the allogeneic anti-CD70-CAR-IL-15-transduced CB-derived NK cells target, bind to and induce selective cytotoxicity in CD70-expressing tumor cells. CD70, the ligand for the costimulatory receptor CD27, is overexpressed on the surfaces of various cancer cell types. IL-15 is a pro-survival cytokine that promotes persistence of multiple lymphocyte lineages and potentiates the immune response against tumor cells."], "t": []}], "preferred_name": "Allogeneic Anti-CD70-CAR-IL-15-transduced Cord Blood-derived Natural Killer Cells", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0002566", "l": "dark melanocyte", "d": ["A melanocyte that appears darker due to content or amount of melanin granules."], "t": []}], "preferred_name": "dark melanocyte", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5157527", "l": "CD3-CD57+ cells | Body fluid | Cell markers", "d": [], "t": []}], "preferred_name": "CD3-CD57+ cells | Body fluid | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5420606", "l": "MAGE-A1-specific T Cell Receptor-transduced Autologous T-cells", "d": [], "t": []}, {"i": "NCIT:C174139", "l": "MAGE-A1-specific T Cell Receptor-transduced Autologous T-cells", "d": ["A preparation of autologous CD4- and CD8-positive T-lymphocytes genetically modified to express a T-cell receptor (TCR) that specifically targets the human melanoma-associated antigen A1 (MAGE-A1), with potential antineoplastic activity. Upon isolation, transduction, expansion ex vivo, and reintroduction into the patient, the MAGE-A1-specific TCR-transduced autologous T-cells bind to tumor cells expressing MAGE-A1, which may halt the growth of and kill MAGE-A1-expressing cancer cells. MAGE-A1 is a tumor-associated antigen (TAA) overexpressed by a variety of cancer cell types."], "t": []}], "preferred_name": "MAGE-A1-specific T Cell Receptor-transduced Autologous T-cells", "taxa": []}
{"type": "biolink:Cell", "ic": 55.877904504111456, "identifiers": [{"i": "UMLS:C1513978", "l": "Neoplastic Glial Cell", "d": [], "t": []}, {"i": "NCIT:C37126", "l": "Neoplastic Glial Cell", "d": [], "t": []}], "preferred_name": "Neoplastic Glial Cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C2936184", "l": "Fibroblast-Derived Induced Pluripotent Stem Cells", "d": [], "t": []}], "preferred_name": "Fibroblast-Derived Induced Pluripotent Stem Cells", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1514024", "l": "Neoplastic Merkel Cell", "d": [], "t": []}, {"i": "NCIT:C37098", "l": "Neoplastic Merkel Cell", "d": [], "t": []}], "preferred_name": "Neoplastic Merkel Cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0872362", "l": "primitive cell", "d": [], "t": []}], "preferred_name": "primitive cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5978036", "l": "CD3 cells | Blood product unit | Cell markers", "d": [], "t": []}], "preferred_name": "CD3 cells | Blood product unit | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1276265", "l": "Bite cell (cell)", "d": [], "t": []}, {"i": "SNOMEDCT:111013009", "l": "", "d": [], "t": []}], "preferred_name": "Bite cell (cell)", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5963537", "l": "Polymorphonuclear Myeloid-Derived Suppressor Cell", "d": [], "t": []}, {"i": "NCIT:C211592", "l": "Polymorphonuclear Myeloid-Derived Suppressor Cell", "d": ["A population of immature polymorphonuclear neutrophil-like myeloid cells that are pathologically activated and potentially have immunosuppressive and tumor promoting activities."], "t": []}], "preferred_name": "Polymorphonuclear Myeloid-Derived Suppressor Cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1267837", "l": "B lymphocyte positive for CD19 antigen", "d": [], "t": []}, {"i": "SNOMEDCT:115417009", "l": "", "d": [], "t": []}], "preferred_name": "B lymphocyte positive for CD19 antigen", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5666817", "l": "Allogeneic Virus-specific T-lymphocytes R-MVST", "d": [], "t": []}, {"i": "NCIT:C186371", "l": "Allogeneic Virus-specific T-lymphocytes R-MVST", "d": ["A preparation of allogeneic T-lymphocytes generated from partially human leukocyte antigen (HLA)-matched healthy donors or from the original allogeneic hematopoietic stem cell transplantation (HSCT) donor, ex-vivo expanded, and specifically reactive to viruses that may include adenovirus (AdV), cytomegalovirus (CMV), Epstein-Barr virus (EBV) and human polyomavirus type I (BKV), with potential antiviral activity. Upon administration, the allogeneic virus-specific T-lymphocytes R-MVST may kill AdV, CMV, EBV and/or BKV-infected cells, and may prevent or reduce the severity of viral infections by these pathogens."], "t": []}], "preferred_name": "Allogeneic Virus-specific T-lymphocytes R-MVST", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5157380", "l": "CD20 cells | XXX | Cell markers", "d": [], "t": []}], "preferred_name": "CD20 cells | XXX | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:2000093", "l": "bronchus fibroblast of lung", "d": ["Any fibroblast of lung that is part of a bronchus."], "t": []}], "preferred_name": "bronchus fibroblast of lung", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1515996", "l": "Anti-gp100 TCR Retroviral Vector-Transduced Autologous PBL", "d": [], "t": []}, {"i": "NCIT:C38136", "l": "Anti-gp100 TCR Retroviral Vector-Transduced Autologous PBL", "d": ["Human peripheral blood lymphocytes (PBL) isolated from a melanoma patient and were engineered to react with the melanoma antigen glycoprotein 100 (gp100). These PBL are transduced with a retroviral pGCsam vector encoding T-cell receptors specific for gp100, grown in culture, and then transferred back to the patient. These genetically modified PBL may recognize and halt the growth of gp100-expressing melanoma cells."], "t": []}], "preferred_name": "Anti-gp100 TCR Retroviral Vector-Transduced Autologous PBL", "taxa": []}
{"type": "biolink:Cell", "ic": 90.871710685482, "identifiers": [{"i": "CL:1000412", "l": "endothelial cell of arteriole", "d": ["An endothelial cell that is part of the arteriole."], "t": []}, {"i": "UMLS:C1180241", "l": "Endothelial cell of arteriole", "d": [], "t": []}], "preferred_name": "endothelial cell of arteriole", "taxa": []}
{"type": "biolink:Cell", "ic": 47.5472341418692, "identifiers": [{"i": "UMLS:C1512108", "l": "Dysplastic Squamous Cell", "d": [], "t": []}, {"i": "NCIT:C36789", "l": "Dysplastic Squamous Cell", "d": [], "t": []}], "preferred_name": "Dysplastic Squamous Cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5175146", "l": "Nucleated cells | Body fluid | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Nucleated cells | Body fluid | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4033065", "l": "preplasmablast", "d": ["A mature B cell that serves as an intermediate stage in the differentiation of naive B cells into a plasmablast. A preplasmablast expresses CD30 and IL-6R and lacks expression of CD20, CD23, CD38 and CD138."], "t": []}], "preferred_name": "preplasmablast", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1370102", "l": "Cells.CD4+CD45RA+/Cells.CD8", "d": [], "t": []}], "preferred_name": "Cells.CD4+CD45RA+/Cells.CD8", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "CL:0002136", "l": "type II cell of adrenal cortex", "d": ["A cell in the zona fasciculata that produce glucocorticoids, e.g cortisol."], "t": []}, {"i": "UMLS:C1181725", "l": "Type II cell of adrenal cortex", "d": [], "t": []}], "preferred_name": "type II cell of adrenal cortex", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:1000697", "l": "kidney interstitial suppressor macrophage", "d": [], "t": []}], "preferred_name": "kidney interstitial suppressor macrophage", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C4724860", "l": "Autologous Mesothelin-specific CAR-T Cells", "d": [], "t": []}, {"i": "NCIT:C148160", "l": "Autologous Mesothelin-specific CAR-T Cells", "d": ["Genetically modified, autologous T-lymphocytes transduced with a gene encoding a chimeric antigen receptor (CAR) specific for the human tumor-associated antigen (TAA) mesothelin, with potential immunomodulating and antineoplastic activities. After isolation, transduction, expansion in culture, and reintroduction into the patient, the autologous mesothelin-specific CAR-T cells specifically target and kill mesothelin-expressing tumor cells. Mesothelin, a cell surface glycoprotein involved in cell adhesion, is overexpressed in a variety of cancer cell types."], "t": []}], "preferred_name": "Autologous Mesothelin-specific CAR-T Cells", "taxa": []}
{"type": "biolink:Cell", "ic": 92.76600187037766, "identifiers": [{"i": "CL:0000388", "l": "tendon cell", "d": ["An elongated fibroblast that is part of a tendon. Its cytoplasm is stretched between the collagen fibres of the tendon, and it possesses a central nucleus with a prominent nucleolus. Tendon cell has a well-developed rough endoplasmic reticulum, and it is responsible for the synthesis and turnover of tendon fibres and ground substance."], "t": []}, {"i": "UMLS:C4277739", "l": "Tenocytes", "d": [], "t": []}, {"i": "MESH:D000070916", "l": "Tenocytes", "d": [], "t": []}], "preferred_name": "tendon cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0444088", "l": "Tissue cell sample", "d": [], "t": []}], "preferred_name": "Tissue cell sample", "taxa": []}
{"type": "biolink:Cell", "ic": 66.33925318234348, "identifiers": [{"i": "CL:0000021", "l": "female germ cell", "d": ["Female germ cell is a germ cell that supports female gamete production."], "t": []}], "preferred_name": "female germ cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5761823", "l": "Attenuated autologous cancer cells and granulocyte macrophage colony stimulating factor in combination with activated autologous blood derived T-cells", "d": [], "t": []}], "preferred_name": "Attenuated autologous cancer cells and granulocyte macrophage colony stimulating factor in combination with activated autologous blood derived T-cells", "taxa": []}
{"type": "biolink:Cell", "ic": 92.76600187037766, "identifiers": [{"i": "CL:0002002", "l": "Kit-positive granulocyte monocyte progenitor", "d": ["A granulocyte monocyte progenitor that is Kit-positive, CD34-positive, Fc-gamma receptor II/II-positive, and is Sca-1-negative, Il7ra-negative, Cxc3r1-negative, and CD90-negative."], "t": []}], "preferred_name": "Kit-positive granulocyte monocyte progenitor", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5171670", "l": "Lymphocytes | Vitreous fluid | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Lymphocytes | Vitreous fluid | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": 35.28616749926292, "identifiers": [{"i": "CL:2000029", "l": "central nervous system neuron", "d": ["Any neuron that is part of a central nervous system."], "t": []}], "preferred_name": "central nervous system neuron", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5157562", "l": "CD41 cells | Blood | Cell markers", "d": [], "t": []}], "preferred_name": "CD41 cells | Blood | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5700423", "l": "AUTO1 CAR-T Cells", "d": [], "t": []}], "preferred_name": "AUTO1 CAR-T Cells", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5163439", "l": "Eosinophils | Fetus | Blood | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Eosinophils | Fetus | Blood | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C4725019", "l": "Partially HLA-matched Adenovirus-specific T Lymphocytes", "d": [], "t": []}, {"i": "NCIT:C148419", "l": "Partially HLA-matched Adenovirus-specific T Lymphocytes", "d": ["A population of frozen, off-the-shelf, ready to administer, allogeneic, partially or closely human leukocyte antigen (HLA) matched cytotoxic T-lymphocytes (CTLs) specifically reactive to human adenovirus (Ad; AdV), with potential immunomodulating and anti-adenoviral activities. Ex vivo, Ad-derived peptides were mixed with peripheral blood mononuclear cells (PBMCs) from healthy donors and the Ad-reactive CTLs were selected, grown and frozen. Upon thawing and infusion, the partially HLA-matched Ad-specific CTLs may help reconstitute Ad-specific CTL responses in patients at risk of developing Ad infections after allogeneic stem cell transplant (HSCT) or in Ad-infected immunocompromised hosts. This may induce killing of Ad-infected cells and may prevent or reduce severity of Ad infection."], "t": []}], "preferred_name": "Partially HLA-matched Adenovirus-specific T Lymphocytes", "taxa": []}
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{"type": "biolink:Cell", "ic": 48.74730412584413, "identifiers": [{"i": "UMLS:C1510779", "l": "Adenocarcinoma Cell", "d": [], "t": []}, {"i": "NCIT:C36773", "l": "Adenocarcinoma Cell", "d": [], "t": []}], "preferred_name": "Adenocarcinoma Cell", "taxa": []}
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{"type": "biolink:Cell", "ic": 92.76600187037766, "identifiers": [{"i": "CL:0001014", "l": "CD1a-positive Langerhans cell", "d": ["CD1a-positive Langerhans cell is a Langerhans_cell that is CD1a-positive and CD324-positive."], "t": []}], "preferred_name": "CD1a-positive Langerhans cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1979638", "l": "Blasts.CD1a", "d": [], "t": []}], "preferred_name": "Blasts.CD1a", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0229609", "l": "Secretory macrophage", "d": [], "t": []}, {"i": "SNOMEDCT:35113007", "l": "", "d": [], "t": []}], "preferred_name": "Secretory macrophage", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1267814", "l": "Lymphocyte positive for CD2 antigen and CD20 antigen", "d": [], "t": []}, {"i": "SNOMEDCT:117517007", "l": "", "d": [], "t": []}], "preferred_name": "Lymphocyte positive for CD2 antigen and CD20 antigen", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4023128", "l": "rostral periventricular region of the third ventricle KNDy neuron", "d": ["a KNDy neuron that is located in the rostral periventricular region of the third ventricle."], "t": []}], "preferred_name": "rostral periventricular region of the third ventricle KNDy neuron", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0009008", "l": "gastrointestinal tract (lamina propria) macrophage of large intestine", "d": ["A macrophage which is resident in the lamina propria of the large intestine."], "t": []}], "preferred_name": "gastrointestinal tract (lamina propria) macrophage of large intestine", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0002142", "l": "dark cell of eccrine sweat gland", "d": ["A cell pyramidal in shape, with their broad ends facing and forming the greater extent of the lining of the main lumen. Secretes glycoproteins associated with mucus."], "t": []}, {"i": "UMLS:C1182693", "l": "Dark cell of eccrine sweat gland", "d": [], "t": []}], "preferred_name": "dark cell of eccrine sweat gland", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1440390", "l": "Cells.hyperdiploid", "d": [], "t": []}], "preferred_name": "Cells.hyperdiploid", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0883468", "l": "CD16+CD56+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:732275003", "l": "", "d": [], "t": []}], "preferred_name": "CD16+CD56+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0677626", "l": "hepatoma cell", "d": [], "t": []}], "preferred_name": "hepatoma cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0000944", "l": "Be2 cell", "d": ["A Be cell that facilitates development of T-helper 2 (Th2) phenotype T cells, and secretes high levels of interleukin-2, interleukin-10, interleukin-4, and interleukin-6."], "t": []}], "preferred_name": "Be2 cell", "taxa": []}
{"type": "biolink:Cell", "ic": 92.76600187037766, "identifiers": [{"i": "CL:4301576", "l": "CB PLI Gly-Gaba_3 Purkinje layer interneuron (Mmus)", "d": ["A Purkinje layer interneuron of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Pax2 (Mmus), C1ql3 (Mmus), Tfap2b (Mmus), Gabrb1 (Mmus). Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Supertype:1146 CB PLI Gly-Gaba_3."], "t": []}], "preferred_name": "CB PLI Gly-Gaba_3 Purkinje layer interneuron (Mmus)", "taxa": []}
{"type": "biolink:Cell", "ic": 89.40238429118027, "identifiers": [{"i": "CL:0002013", "l": "GlyA-positive basophilic erythroblast", "d": ["A basophilic erythroblast that is GlyA-positive."], "t": []}], "preferred_name": "GlyA-positive basophilic erythroblast", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4052011", "l": "follicle associated enterocyte", "d": ["An enterocyte found in the follicle-associated epithelium (FAE) that covers Peyer's patches and other mucosa-associated lymphoid tissues. This cell has reduced absorptive capacity and expresses higher levels of chemokines CCL20 and CXCL16, compared to regular villus enterocytes. It contributes to antigen sampling and immune interactions, supporting the specialized function of the FAE in mucosal immunity."], "t": []}], "preferred_name": "follicle associated enterocyte", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5171671", "l": "Lymphocytes | XXX | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Lymphocytes | XXX | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": 85.53200374075534, "identifiers": [{"i": "CL:0002417", "l": "primitive erythroid lineage cell", "d": ["An immature or mature cell of the first erythroid lineage to arise during embryonic development."], "t": []}], "preferred_name": "primitive erythroid lineage cell", "taxa": []}
{"type": "biolink:Cell", "ic": 87.18682603146104, "identifiers": [{"i": "UMLS:C0206441", "l": "Pyramidal Cells", "d": [], "t": []}, {"i": "NCIT:C12652", "l": "Pyramidal Cell", "d": ["A neuron located in the cerebral cortex, hippocampus, and amygdala that is characterized by a pyramidal-shaped cell body and apical and basal dendritic trees. Pyramidal cells are involved in complex cortical functions."], "t": []}, {"i": "MESH:D017966", "l": "Pyramidal Cells", "d": [], "t": []}, {"i": "SNOMEDCT:17522008", "l": "", "d": [], "t": []}], "preferred_name": "Pyramidal Cells", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5549477", "l": "Spermatozoa Motile | Urine | Fertility testing", "d": [], "t": []}], "preferred_name": "Spermatozoa Motile | Urine | Fertility testing", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5174612", "l": "Neutrophils | Blood | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Neutrophils | Blood | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": 72.0250656653823, "identifiers": [{"i": "CL:0000025", "l": "egg cell", "d": ["A female gamete where meiosis has progressed to metaphase II and is able to participate in fertilization."], "t": []}, {"i": "UMLS:C0029974", "l": "Ovum", "d": [], "t": []}, {"i": "MESH:D010063", "l": "Ovum", "d": [], "t": []}, {"i": "SNOMEDCT:263828003", "l": "", "d": [], "t": []}, {"i": "SNOMEDCT:308796009", "l": "", "d": [], "t": []}, {"i": "SNOMEDCT:73153001", "l": "", "d": [], "t": []}], "preferred_name": "egg cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0597690", "l": "WI38 cell", "d": [], "t": []}], "preferred_name": "WI38 cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5156213", "l": "Burr cells | Blood | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Burr cells | Blood | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1514077", "l": "Neoplastic Round Cell with Lipomatous Differentiation", "d": [], "t": []}, {"i": "NCIT:C37102", "l": "Neoplastic Round Cell with Lipomatous Differentiation", "d": [], "t": []}], "preferred_name": "Neoplastic Round Cell with Lipomatous Differentiation", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0004231", "l": "recurving diffuse amacrine cell", "d": ["A broadly stratifying amacrine cell with a small dendritic field and a complex dendritic arbor. Recurving diffuse amacrine cells have post-synaptic terminals in S2, S3, and S4."], "t": []}], "preferred_name": "recurving diffuse amacrine cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C4087054", "l": "Donor-derived WT1/PRAME/NY-ESO-1/Survivin-specific T-lymphocytes", "d": [], "t": []}, {"i": "NCIT:C123817", "l": "Donor-derived WT1/PRAME/NY-ESO-1/Survivin-specific T-lymphocytes", "d": ["Allogeneic T-lymphocytes specifically reactive to the tumor-associated antigens (TAAs) human Wilms tumor protein-1 (WT1), Preferentially Expressed Antigen in Melanoma (PRAME), the cancer-testis antigen NY-ESO-1, and survivin, with potential antineoplastic activity. Donor derived T-cells are mixed, ex vivo, with protein fragments derived from the TAAs WT1, PRAME, NY-ESO-1, and survivin. Upon intravenous administration, the donor-derived WT1/PRAME/NY-ESO-1/Survivin-specific T-lymphocytes recognize and kill cancer cells expressing these TAAs. WT1, NY-ESO-1, PRAME, and survivin, are expressed on certain tumor cell types and play key role in tumor cell proliferation and survival."], "t": []}], "preferred_name": "Donor-derived WT1/PRAME/NY-ESO-1/Survivin-specific T-lymphocytes", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C2599947", "l": "Purkinje cell cytoplasmic type 1", "d": [], "t": []}], "preferred_name": "Purkinje cell cytoplasmic type 1", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0546492", "l": "P.B. neutrophilic myelocyte", "d": [], "t": []}], "preferred_name": "P.B. neutrophilic myelocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:1001221", "l": "arcuate vein smooth muscle cell", "d": ["Any smooth muscle cell that is part of some kidney arcuate vein."], "t": []}], "preferred_name": "arcuate vein smooth muscle cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5446937", "l": "Autologous Anti-NY-ESO-1 TCR/CD8alpha-expressing T-cells GSK3901961", "d": [], "t": []}, {"i": "NCIT:C176040", "l": "Autologous Anti-NY-ESO-1 TCR/CD8alpha-expressing T-cells GSK3901961", "d": ["A preparation of human autologous T-lymphocytes that are genetically modified to express a T-cell receptor (TCR) specific for the human cancer-testis antigen NY-ESO-1 and the CD8alpha co-receptor, with potential immunostimulating and antineoplastic activities. Upon leukapheresis, isolation, transduction, expansion ex vivo, and reintroduction into the patient, the autologous anti-NY-ESO-1 TCR/CD8alpha-expressing T-cells GSK3901961 recognize and bind to NY-ESO-1-overexpressing tumor cells. This may result in a specific cytotoxic T-lymphocyte (CTL)-mediated killing of NY-ESO-1-positive tumor cells. NY-ESO-1, a tumor-associated antigen (TAA), is found in normal testis and on the surface of various tumor cell types. Co-expression of CD8alpha may broaden the immune response against tumors and increase antitumor activity by converting CD4+ helper T-cells into CD8+ cytotoxic T-cells."], "t": []}], "preferred_name": "Autologous Anti-NY-ESO-1 TCR/CD8alpha-expressing T-cells GSK3901961", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0002205", "l": "brush cell of lobular bronchiole", "d": ["A brush cell found in the epithelium of lobular bronchiole."], "t": []}, {"i": "UMLS:C2331834", "l": "Brush cell of epithelium of lobular bronchiole", "d": [], "t": []}], "preferred_name": "brush cell of lobular bronchiole", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0000742", "l": "periarticular chondrocyte", "d": ["A round chondrocyte that first differentiates in the late embryonic growth plate of bone."], "t": []}], "preferred_name": "periarticular chondrocyte", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4518165", "l": "Population of all spermatozoa with abnormal head shape in portion of fluid", "d": [], "t": []}, {"i": "SNOMEDCT:725223008", "l": "", "d": [], "t": []}], "preferred_name": "Population of all spermatozoa with abnormal head shape in portion of fluid", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5978015", "l": "Epithelial cells | Urethra | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Epithelial cells | Urethra | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": 70.22551955196433, "identifiers": [{"i": "CL:0000669", "l": "pericyte", "d": ["An elongated, contractile cell found wrapped about precapillary arterioles outside the basement membrane. Pericytes are present in capillaries where proper adventitia and muscle layer are missing (thus distingushing this cell type from adventitial cells). They are relatively undifferentiated and may become fibroblasts, macrophages, or smooth muscle cells."], "t": []}, {"i": "UMLS:C0598800", "l": "Pericytes", "d": [], "t": []}, {"i": "NCIT:C12656", "l": "Pericyte", "d": ["A multipotent perivascular cell that is embedded in the basement membrane of capillaries and contributes to tissue repair in response to injury."], "t": []}, {"i": "MESH:D020286", "l": "Pericytes", "d": [], "t": []}, {"i": "SNOMEDCT:34773004", "l": "", "d": [], "t": []}], "preferred_name": "pericyte", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0002175", "l": "primary follicular cell of ovary", "d": ["A cell within the primary follicle of the ovary."], "t": []}, {"i": "UMLS:C1182636", "l": "Primary follicular cell of ovary", "d": [], "t": []}], "preferred_name": "primary follicular cell of ovary", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4321645", "l": "Set of embryonic stem cells", "d": [], "t": []}], "preferred_name": "Set of embryonic stem cells", "taxa": []}
{"type": "biolink:Cell", "ic": 88.20185721311867, "identifiers": [{"i": "UMLS:C5856861", "l": "Anti-CD38 CAR T Cells Preparation", "d": [], "t": []}, {"i": "NCIT:C201510", "l": "Anti-CD38 CAR T Cells Preparation", "d": ["A preparation of T-lymphocytes that  express a chimeric antigen receptor (CAR) specific for the tumor-associated antigen (TAA) CD38."], "t": []}], "preferred_name": "Anti-CD38 CAR T Cells Preparation", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5186196", "l": "Donated egg | Patient | Fertility testing", "d": [], "t": []}], "preferred_name": "Donated egg | Patient | Fertility testing", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "CL:4023006", "l": "static nuclear bag fiber", "d": ["A nuclear bag fiber that is sensitive only changes in muscle length but not the rate of that change."], "t": []}], "preferred_name": "static nuclear bag fiber", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5419239", "l": "Avoplacel", "d": [], "t": []}, {"i": "NCIT:C171652", "l": "Avoplacel", "d": [], "t": []}], "preferred_name": "Avoplacel", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5151350", "l": "Abnormal lymphocytes | Cerebral spinal fluid | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Abnormal lymphocytes | Cerebral spinal fluid | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4047060", "l": "BAG3-positive monocyte", "d": ["A circulating mononuclear phagocyte characterized by the expression of BCL-2-associated athanogene 3 (BAG3) protein, a co-chaperone involved in protein quality control and anti-apoptotic processes. (Fontanella, 2009). It undergoes cellular stress during the differentiation into M2 macrophages and is linked to poor survival rates in multiple cancer types. (Park, 2023)"], "t": []}], "preferred_name": "BAG3-positive monocyte", "taxa": []}
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{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0333718", "l": "Anuclear cell", "d": [], "t": []}, {"i": "SNOMEDCT:54656004", "l": "", "d": [], "t": []}], "preferred_name": "Anuclear cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5446539", "l": "Autologous CLL1-CAR-CD28-expressing T-lymphocytes", "d": [], "t": []}, {"i": "NCIT:C175458", "l": "Autologous CLL1-CAR-CD28-expressing T-lymphocytes", "d": ["A preparation of autologous T-lymphocytes expressing a chimeric antigen receptor (CAR) specific for the tumor-associated antigen (TAA) C-type-lectin-like molecule-1 (CLL1; C-type lectin domain family 12 member A; CLEC12A) linked to the CD28 co-stimulatory signaling domain, with potential immunomodulating and antineoplastic activities. Upon administration, the autologous CLL1-CAR-CD28-expressing T-lymphocytes specifically target and bind to CLL1-expressing tumor cells. This induces selective toxicity in tumor cells that express the CLL1 antigen. CLL1, a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily, is overexpressed in leukemic stem cells (LSCs) and plays an important role in disease progression and relapse for myeloid malignancies."], "t": []}], "preferred_name": "Autologous CLL1-CAR-CD28-expressing T-lymphocytes", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C3282679", "l": "foreskin keratinocyte, neonatal", "d": [], "t": []}], "preferred_name": "foreskin keratinocyte, neonatal", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C0020204", "l": "Hybridomas", "d": [], "t": []}, {"i": "NCIT:C16700", "l": "Hybridoma", "d": ["A tumor of hybrid cells used in the in vitro production of specific monoclonal antibodies; produced by fusion of an established tissue culture line of lymphocyte tumor cells (e.g., mouse plasmacytoma cells) and specific antibody-producing cells (e.g., splenocytes from specifically immunized mice); fusions are accomplished by use of polyethylene glycol or other methods."], "t": []}, {"i": "MESH:D006825", "l": "Hybridomas", "d": [], "t": []}, {"i": "SNOMEDCT:25326005", "l": "", "d": [], "t": []}], "preferred_name": "Hybridomas", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4727694", "l": "Satricabtagene autoleucel", "d": [], "t": []}], "preferred_name": "Satricabtagene autoleucel", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0229616", "l": "Small lymphocyte", "d": [], "t": []}, {"i": "SNOMEDCT:91233007", "l": "", "d": [], "t": []}], "preferred_name": "Small lymphocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5783520", "l": "Autologous Anti-Siglec-6 CAR-T Cells", "d": [], "t": []}, {"i": "NCIT:C190142", "l": "Autologous Anti-Siglec-6 CAR-T Cells", "d": ["A preparation of autologous T-lymphocytes that have been genetically engineered to express a chimeric antigen receptor (CAR) targeting sialic acid-binding immunoglobulin (Ig)-like lectin 6 (Siglec-6) and containing, as of yet undisclosed co-stimulatory signaling domains, with potential immunostimulating and antineoplastic activities. Upon infusion back into the patient, autologous anti-Siglec-6 CAR-T cells target and bind to Siglec-6-expressing tumor cells, thereby inducing selective toxicity in Siglec-6-expressing tumor cells. Siglec-6 is overexpressed in certain malignancies, including acute myeloid leukemia (AML) and chronic lymphocytic leukemia (CLL), and not expressed in normal hematopoietic stem and progenitor cells (HSPCs)."], "t": []}], "preferred_name": "Autologous Anti-Siglec-6 CAR-T Cells", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C3899314", "l": "EGFRvIII-specific CAR-transduced Autologous T Lymphocytes", "d": [], "t": []}, {"i": "NCIT:C117727", "l": "EGFRvIII-specific CAR-transduced Autologous T Lymphocytes", "d": ["Autologous human T-lymphocytes transduced with a retroviral vector encoding an anti-epidermal growth factor receptor variant III (EGFRvIII) mutant chimeric T-cell receptor (chimeric antigen receptor or CAR) gene, with potential immunostimulatory and antineoplastic activities. Upon administration, the EGFRvIII-specific CAR-transduced autologous T-lymphocytes bind to the EGFRvIII antigen on tumor cell surfaces; subsequently, EGFRvIII-expressing tumor cells may be lysed. EGFRvIII, an in-frame deletion of exons 2-7 in the EGFR gene, is overexpressed by a variety of cancer cell types but absent in normal, healthy cells. It plays a key role in tumor cell proliferation, tumor angiogenesis and resistance to both radio- and chemotherapy."], "t": []}], "preferred_name": "EGFRvIII-specific CAR-transduced Autologous T Lymphocytes", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5854423", "l": "Allogeneic CRISPR-edited Anti-BCMA CAR-T Cells CB-011", "d": [], "t": []}, {"i": "NCIT:C199479", "l": "Allogeneic CRISPR-edited Anti-BCMA CAR-T Cells CB-011", "d": ["A preparation of allogeneic, off-the-shelf T-lymphocytes genetically modified and clustered regularly interspaced short palindromic repeats (CRISPR)-edited to contain a deletion of the TRAC gene, a site-specific insertion of a chimeric antigen receptor (CAR) specific for the tumor-associated antigen (TAA) B-cell maturation antigen (BCMA; tumor necrosis factor receptor superfamily member 17; TNFRSF17) into the TRAC gene, a deletion of the B2M gene, and a site-specific insertion of a gene encoding a B2M-HLA-E-peptide fusion into the B2M gene, with potential immunostimulating and antineoplastic activities. Upon administration, the allogeneic CRISPR-edited anti-BCMA CAR-T cells CB-011 recognize and bind to BCMA-expressing tumor cells. This may result in a specific cytotoxic T-lymphocyte (CTL)-mediated killing of BCMA-positive tumor cells. Knock out of the TRAC gene eliminates the endogenous T-cell receptors (TCRs), thereby preventing graft-versus-host disease (GvHD). The B2M protein is removed to eliminate endogenous HLA class I expression on the surface of the CB-011 CAR-T cells, which protects the CAR-T cells from host T-cell rejection. The B2M-HLA-E fusion protein is inserted to protect the CAR-T cells from host natural killer (NK) cell rejection. BCMA, a receptor for both a proliferation-inducing ligand (APRIL) and B-cell activating factor (BAFF), is a member of the tumor necrosis factor receptor superfamily (TNFRSF). BCMA is found on the surfaces of plasma cells, is overexpressed on malignant plasma cells and plays a key role in plasma cell proliferation and survival."], "t": []}], "preferred_name": "Allogeneic CRISPR-edited Anti-BCMA CAR-T Cells CB-011", "taxa": []}
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{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0019026", "l": "periportal region hepatocyte", "d": ["Any hepatocyte that is part of the liver lobule periportal region. These cells are primarily involved in oxidative energy metabolism."], "t": []}], "preferred_name": "periportal region hepatocyte", "taxa": []}
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{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1267847", "l": "Lymphocyte positive for both CD5 antigen and CD20 antigen", "d": [], "t": []}, {"i": "SNOMEDCT:117534004", "l": "", "d": [], "t": []}], "preferred_name": "Lymphocyte positive for both CD5 antigen and CD20 antigen", "taxa": []}
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{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5171959", "l": "Malignant cells | Blood | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Malignant cells | Blood | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5557580", "l": "AloCelyvir", "d": [], "t": []}], "preferred_name": "AloCelyvir", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0000445", "l": "apoptosis fated cell", "d": [], "t": []}], "preferred_name": "apoptosis fated cell", "taxa": []}
{"type": "biolink:Cell", "ic": 73.85694246010084, "identifiers": [{"i": "CL:0000637", "l": "chromophil cell of anterior pituitary gland", "d": ["A cell that stains readily in the anterior pituitary gland."], "t": []}], "preferred_name": "chromophil cell of anterior pituitary gland", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0546496", "l": "P.B. monoblast", "d": [], "t": []}], "preferred_name": "P.B. monoblast", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "CL:0000618", "l": "sheath cell", "d": [], "t": []}], "preferred_name": "sheath cell", "taxa": []}
{"type": "biolink:Cell", "ic": 79.07356789860069, "identifiers": [{"i": "CL:1000409", "l": "myocyte of sinoatrial node", "d": ["A muscle cell that is part of the sinoatrial node."], "t": []}], "preferred_name": "myocyte of sinoatrial node", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5977364", "l": "CD3+CD14-CD45+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:1373222000", "l": "", "d": [], "t": []}], "preferred_name": "CD3+CD14-CD45+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C3179110", "l": "Feeder Cells", "d": [], "t": []}, {"i": "MESH:D061252", "l": "Feeder Cells", "d": [], "t": []}], "preferred_name": "Feeder Cells", "taxa": []}
{"type": "biolink:Cell", "ic": 89.40238429118027, "identifiers": [{"i": "CL:0009016", "l": "intestinal crypt stem cell of large intestine", "d": ["An intestinal stem cell that is located in the large intestine crypt of Liberkuhn. These stem cells reside at the bottom of crypts in the large intestine and are highly proliferative. They either differentiate into transit amplifying cells or self-renew to form new stem cells."], "t": []}], "preferred_name": "intestinal crypt stem cell of large intestine", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1440315", "l": "CD45RA+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:1372891004", "l": "", "d": [], "t": []}], "preferred_name": "CD45RA+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": 78.80476858236055, "identifiers": [{"i": "UMLS:C1882063", "l": "Nephrogenic Blastemal Cell", "d": [], "t": []}, {"i": "NCIT:C61287", "l": "Nephrogenic Blastemal Cell", "d": [], "t": []}], "preferred_name": "Nephrogenic Blastemal Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5855517", "l": "Allogeneic Anti-CD19 T-cells ThisCART19A", "d": [], "t": []}, {"i": "NCIT:C199286", "l": "Allogeneic Anti-CD19 T-cells ThisCART19A", "d": ["A preparation of allogeneic engineered T-lymphocytes expressing a lentiviral vector encoding chimeric antigen receptor (CAR) targeting the tumor-associated antigen (TAA) CD19 and an anti-CD3 single chain antibody with the KDEL peptide fused to its C-terminus, with potential immunostimulating and antineoplastic activities. Upon administration, allogeneic anti-CD19 CAR T-cells ThisCART19A specifically target and bind to CD19-expressing tumor cells, thereby selectively lysing CD19-expressing tumor cells. CD19 antigen is a B-cell specific cell surface antigen expressed in all B-cell lineage malignancies. By eliminating TCR/CD3 expression, the potential induction of graft-versus-host disease (GvHD) by the donor T-cells is abrogated."], "t": []}], "preferred_name": "Allogeneic Anti-CD19 T-cells ThisCART19A", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C3896917", "l": "siRNA-transfected Peripheral Blood Mononuclear Cells APN401", "d": [], "t": []}, {"i": "NCIT:C116353", "l": "siRNA-transfected Peripheral Blood Mononuclear Cells APN401", "d": ["Autologous peripheral blood mononuclear cells (PBMCs) transfected ex vivo with small-interfering ribonucleic acid (siRNA) directed against the E3 ubiquitin ligase casitas B-lineage lymphoma-b gene (Cbl-b), with potential immunoactivating and antineoplastic activities. The Cbl-b gene is silenced ex vivo through the binding of Cbl-b siRNA to Cbl-b mRNA, which prevents the translation of the Cbl-b protein in T-lymphocytes. Upon infusion, the activated, Cbl-b-silenced T-lymphocytes are able to increase the production of cytokines, proliferate and activate the immune system, which leads to cancer cell eradication. Cbl-b, a negative regulator of the immune system, is mutated in a variety of cancer cell types. Its expression is inversely correlated with activation of T-lymphocytes and tumor cell eradication."], "t": []}], "preferred_name": "siRNA-transfected Peripheral Blood Mononuclear Cells APN401", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4070010", "l": "gastric mill neuron", "d": ["A motor neuron that moves the medial tooth forward"], "t": []}], "preferred_name": "gastric mill neuron", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4518158", "l": "Population of all motile spermatozoa in portion of fluid", "d": [], "t": []}, {"i": "SNOMEDCT:726584006", "l": "", "d": [], "t": []}], "preferred_name": "Population of all motile spermatozoa in portion of fluid", "taxa": []}
{"type": "biolink:Cell", "ic": 77.17927671370501, "identifiers": [{"i": "UMLS:C1515880", "l": "Activated Mature Cytotoxic T-Lymphocyte", "d": [], "t": []}, {"i": "NCIT:C39687", "l": "Activated Mature Cytotoxic T-Lymphocyte", "d": ["A white blood cell that is derived from a lymphocyte stem cell matured in the thymus and characterized by a CD8 marker on the surface and an antigen-specific T cell receptor which recognizes antigens in the context of MHC class I."], "t": []}], "preferred_name": "Activated Mature Cytotoxic T-Lymphocyte", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0545585", "l": "Blood small lymphocyte", "d": [], "t": []}], "preferred_name": "Blood small lymphocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C2360256", "l": "Anulocyte", "d": [], "t": []}, {"i": "NCIT:C206311", "l": "Anulocyte", "d": ["An abnormal red blood cell with a single concave surface, sometimes observed in conditions of severe iron deficiency."], "t": []}, {"i": "SNOMEDCT:724194007", "l": "", "d": [], "t": []}], "preferred_name": "Anulocyte", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5178307", "l": "Promyelocytes | Body fluid | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Promyelocytes | Body fluid | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C3496529", "l": "A14 dopamine cells", "d": [], "t": []}], "preferred_name": "A14 dopamine cells", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5978060", "l": "Lymphocytes | Bone marrow | Cell markers", "d": [], "t": []}], "preferred_name": "Lymphocytes | Bone marrow | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C3176906", "l": "Cytoplasmic CD3+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:1373304000", "l": "", "d": [], "t": []}], "preferred_name": "Cytoplasmic CD3+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5157437", "l": "CD3+CD4+ (T4 helper) cells | Cerebral spinal fluid | Cell markers", "d": [], "t": []}], "preferred_name": "CD3+CD4+ (T4 helper) cells | Cerebral spinal fluid | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5163552", "l": "Epithelial cells.renal | Urine | Urinalysis", "d": [], "t": []}], "preferred_name": "Epithelial cells.renal | Urine | Urinalysis", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5157469", "l": "CD3+HLA-DR+ cells | Tissue and Smears | Cell markers", "d": [], "t": []}], "preferred_name": "CD3+HLA-DR+ cells | Tissue and Smears | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5856193", "l": "Allogeneic Anti-interleukin-13 Receptor Alpha 2 Universal CAR-T Cells", "d": [], "t": []}, {"i": "NCIT:C200279", "l": "Allogeneic Anti-interleukin-13 Receptor Alpha 2 Universal CAR-T Cells", "d": ["A preparation of allogeneic, off-the-shelf (OTS), universal, gene-edited T-lymphocytes expressing a chimeric antigen receptor (CAR) specific for interleukin-13 receptor alpha 2 (IL13Ra2), with potential immunostimulating and antineoplastic activities. Upon administration, allogeneic anti-IL13Ra2 UCAR-T cells target and bind to IL13Ra2 expressed on the surface of tumor cells. This induces selective toxicity in tumor cells expressing IL13Ra2. IL13Ra2, a cancer-associated receptor, is overexpressed by a variety of tumor cell types including glioblastoma multiforme (GBM); it is associated with increased invasiveness of tumor cells."], "t": []}], "preferred_name": "Allogeneic Anti-interleukin-13 Receptor Alpha 2 Universal CAR-T Cells", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C4733638", "l": "Allogeneic HPV-specific Cytotoxic T Lymphocytes", "d": [], "t": []}, {"i": "NCIT:C155881", "l": "Allogeneic HPV-specific Cytotoxic T Lymphocytes", "d": ["A population of allogeneic cytotoxic T-lymphocytes (CTLs) that are specifically reactive to human papillomavirus (HPV), with potential antiviral and antineoplastic activities. Upon infusion of the allogeneic HPV-specific CTLs, these CTLs induce selective toxicity in HPV-positive cancer cells and other HPV-infected cells. HPV is associated with various cancer cell types."], "t": []}], "preferred_name": "Allogeneic HPV-specific Cytotoxic T Lymphocytes", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5157353", "l": "CD19+CD27+IgD+IgM+ cells | Blood | Cell markers", "d": [], "t": []}], "preferred_name": "CD19+CD27+IgD+IgM+ cells | Blood | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4033030", "l": "diffuse bipolar 3b cell", "d": ["An OFF calbindin-negative bipolar cell that has a large dendritic field and stratifies narrowly close to the middle of the inner plexiform layer. Its axon terminal is characterized by regularly branching and varicose processes resembling beads on a string. Most of DB3b contacts with cones are non-triad-associated."], "t": []}], "preferred_name": "diffuse bipolar 3b cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0596713", "l": "horizontal cell", "d": [], "t": []}], "preferred_name": "horizontal cell", "taxa": []}
{"type": "biolink:Cell", "ic": 72.11981073685999, "identifiers": [{"i": "CL:4023057", "l": "cerebellar inhibitory GABAergic interneuron", "d": ["A GABAergic interneuron whose soma is located in the cerebellar cortex.", "Any GABAergic interneuron that has its soma located in some cerebellar cortex."], "t": []}], "preferred_name": "cerebellar inhibitory GABAergic interneuron", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5157327", "l": "CD16+CD56+ cells | XXX | Cell markers", "d": [], "t": []}], "preferred_name": "CD16+CD56+ cells | XXX | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": 80.27409497666227, "identifiers": [{"i": "UMLS:C0018207", "l": "granulosa cell", "d": [], "t": []}, {"i": "NCIT:C12587", "l": "Granulosa Cell", "d": [], "t": []}, {"i": "NCIT:C41607", "l": "Ovarian Granulosa Cell", "d": ["A cuboidal cell derived from a spindle-shaped granulosa cell precursor. Initially, ovarian granulosa cells create a single layer surrounding an oocyte. The oocyte and its single layer of ovarian granulosa cells make up a primary follicle. Proliferation of the ovarian granulosa cells leads to multiple cell layers surrounding the oocyte and maturation into a secondary follicle. The granulosa cells extend cytoplasmic processes to form gestational gap-junction-like unions with the plasma membrane of the oocyte. The continued growth of the ovarian granulosa cells takes the oocyte to the Graafian follicle stage. Once ovulation occurs, the granulosa cells become part of the corpus luteum. A major function of an ovarian granulosa cell is hormone production and secretion."], "t": []}, {"i": "MESH:D006107", "l": "Granulosa Cells", "d": [], "t": []}], "preferred_name": "granulosa cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1514180", "l": "Pleomorphic Smooth Muscle Cell", "d": [], "t": []}, {"i": "NCIT:C36946", "l": "Pleomorphic Smooth Muscle Cell", "d": [], "t": []}], "preferred_name": "Pleomorphic Smooth Muscle Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 90.871710685482, "identifiers": [{"i": "UMLS:C1511446", "l": "Mouse Oligodendroglial Cell", "d": [], "t": []}, {"i": "NCIT:C22620", "l": "Mouse Oligodendroglial Cell", "d": [], "t": []}], "preferred_name": "Mouse Oligodendroglial Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 84.83823963392128, "identifiers": [{"i": "UMLS:C1511247", "l": "Bone Marrow Stem Cell at the Earliest Stage of Myeloid Differentiation", "d": [], "t": []}, {"i": "NCIT:C41061", "l": "Bone Marrow Stem Cell at the Earliest Stage of Myeloid Differentiation", "d": ["An undifferentiated cell which can undergo division and can give rise to any of the early stage myeloid cells."], "t": []}], "preferred_name": "Bone Marrow Stem Cell at the Earliest Stage of Myeloid Differentiation", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5705653", "l": "Allogeneic human retinal pigment epithelial cells on gelatin microcarriers", "d": [], "t": []}], "preferred_name": "Allogeneic human retinal pigment epithelial cells on gelatin microcarriers", "taxa": []}
{"type": "biolink:Cell", "ic": 86.30756602822301, "identifiers": [{"i": "CL:0002306", "l": "epithelial cell of proximal tubule", "d": ["An epithelial cell of the proximal tubule of the kidney."], "t": []}, {"i": "UMLS:C1182792", "l": "Epithelial cell of proximal tubule", "d": [], "t": []}], "preferred_name": "epithelial cell of proximal tubule", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0001049", "l": "activated CD8-positive, alpha-beta T cell, human", "d": ["A recently activated CD8-positive, alpha-beta T cell with the phenotype HLA-DRA-positive, CD38-positive, CD69-positive, CD62L-negative, CD127-negative, CCR7-negative, and CD25-positive."], "t": []}], "preferred_name": "activated CD8-positive, alpha-beta T cell, human", "taxa": []}
{"type": "biolink:Cell", "ic": 92.76600187037766, "identifiers": [{"i": "CL:0000654", "l": "primary oocyte", "d": ["A primary oocyte is an oocyte that has not completed female meosis I."], "t": []}], "preferred_name": "primary oocyte", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0805579", "l": "Cerebroventricular lining cells", "d": [], "t": []}], "preferred_name": "Cerebroventricular lining cells", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0883472", "l": "CD3-CD16+CD56+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:732281006", "l": "", "d": [], "t": []}], "preferred_name": "CD3-CD16+CD56+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0682697", "l": "Golgi type II neuron", "d": [], "t": []}], "preferred_name": "Golgi type II neuron", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C6022430", "l": "Cell negative for CD8 antigen and positive for CD57 antigen", "d": [], "t": []}, {"i": "SNOMEDCT:1373189004", "l": "", "d": [], "t": []}], "preferred_name": "Cell negative for CD8 antigen and positive for CD57 antigen", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:1000291", "l": "myocyte of posterior internodal tract", "d": ["A muscle cell that is part of the posterior internodal tract."], "t": []}, {"i": "UMLS:C2325022", "l": "Myocyte of posterior internodal tract", "d": [], "t": []}], "preferred_name": "myocyte of posterior internodal tract", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5173499", "l": "Mononuclear cells | Pleural fluid | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Mononuclear cells | Pleural fluid | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": 51.428136623448694, "identifiers": [{"i": "CL:0010012", "l": "cerebral cortex neuron", "d": ["A CNS neuron of the cerebral cortex."], "t": []}, {"i": "UMLS:C2333134", "l": "Neuron of cerebral cortex", "d": [], "t": []}], "preferred_name": "cerebral cortex neuron", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:2000048", "l": "anterior horn motor neuron", "d": ["A lower motor neuron whose soma is located in the anterior horn. Anterior horn motor neurons project from the anterior portion of the grey matter in the spinal cord to some skeletal muscles."], "t": []}], "preferred_name": "anterior horn motor neuron", "taxa": []}
{"type": "biolink:Cell", "ic": 70.51821968886674, "identifiers": [{"i": "UMLS:C1708883", "l": "Malignant Hyperchromatic Epithelial Cell", "d": [], "t": []}, {"i": "NCIT:C54245", "l": "Malignant Hyperchromatic Epithelial Cell", "d": [], "t": []}], "preferred_name": "Malignant Hyperchromatic Epithelial Cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5853550", "l": "allogenic bone-marrow-derived mesenchymal stem cells", "d": [], "t": []}], "preferred_name": "allogenic bone-marrow-derived mesenchymal stem cells", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C6064638", "l": "TNFRSF13B+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:1373082005", "l": "", "d": [], "t": []}], "preferred_name": "TNFRSF13B+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5963427", "l": "Allogeneic Gamma-delta T-lymphocytes KB-GDT-01", "d": [], "t": []}], "preferred_name": "Allogeneic Gamma-delta T-lymphocytes KB-GDT-01", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C6063262", "l": "FMC7+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:1373072009", "l": "", "d": [], "t": []}], "preferred_name": "FMC7+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1512308", "l": "HL-60/MX1", "d": [], "t": []}, {"i": "NCIT:C20230", "l": "HL-60/MX1", "d": ["HL-60/MX1 is a mitoxantrone resistant derivative of the HL-60 cell line. The cells were selected and subcloned in 1987 for resistance to 39 nM mitoxantrone, an anthracenedione antitumor agent. Subsequent exposure of the HL-60/MX1 cells to higher concentrations of mitoxantrone led to the emergence of cells capable of growth at 190 nM. HL-60/MX1 cells are cross resistant to etoposide, teniposide, bisantrene, actinomycin, 4'-(9-acridinylamino)methane-sulfon-m-anisidide, and the anthracyclines daunorubicin and doxorubicin but retain sensitivity to the Vinca alkaloids vincristine and vinblastine, melphalan, mitomycin C and cisplatin."], "t": []}], "preferred_name": "HL-60/MX1", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1517771", "l": "Lepra Cell", "d": [], "t": []}, {"i": "NCIT:C36737", "l": "Lepra Cell", "d": [], "t": []}], "preferred_name": "Lepra Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0000603", "l": "dikaryon", "d": ["A fungal cell with two genetically distinct haploid nuclei."], "t": []}], "preferred_name": "dikaryon", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5184823", "l": "Variant lymphocytes | Pleural fluid | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Variant lymphocytes | Pleural fluid | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5216197", "l": "Blasts|NCnc|Pt|Body fld", "d": [], "t": []}], "preferred_name": "Blasts|NCnc|Pt|Body fld", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5186228", "l": "Erythrocytes | Fetus | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Erythrocytes | Fetus | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1507326", "l": "CD158+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:1372850001", "l": "", "d": [], "t": []}], "preferred_name": "CD158+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": 60.7318047844785, "identifiers": [{"i": "CL:0008028", "l": "visual system neuron", "d": ["Any neuron that is capable of part of some visual perception."], "t": []}], "preferred_name": "visual system neuron", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:1000330", "l": "serous cell of epithelium of trachea", "d": ["A serous secreting cell that is part of the epithelium of trachea."], "t": []}, {"i": "UMLS:C2339101", "l": "Serous cell of epithelium of trachea", "d": [], "t": []}], "preferred_name": "serous cell of epithelium of trachea", "taxa": []}
{"type": "biolink:Cell", "ic": 92.76600187037766, "identifiers": [{"i": "CL:0002025", "l": "CD34-positive, CD41-positive, CD42-negative megakaryocyte progenitor cell", "d": ["A megakaryocyte progenitor cell that is CD34-positive, CD41-positive, and CD42-negative."], "t": []}], "preferred_name": "CD34-positive, CD41-positive, CD42-negative megakaryocyte progenitor cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5447497", "l": "Allogeneic shRNA-based Anti-BCMA CAR T-cells CYAD-211", "d": [], "t": []}, {"i": "NCIT:C176885", "l": "Allogeneic shRNA-based Anti-BCMA CAR T-cells CYAD-211", "d": ["A preparation of human allogeneic, 'off-the-shelf' (OTS), non-gene edited T-lymphocytes that are engineered to co-express a chimeric antigen receptor (CAR) specific for the tumor-associated antigen (TAA) human B-cell maturation antigen (BCMA; tumor necrosis factor receptor superfamily member 17; TNFRSF17) and a single short hairpin RNA (shRNA) that disrupts the expression of the CD3zeta component of the T-cell receptor (TCR), with potential immunostimulating and antineoplastic activities. Upon administration, the allogeneic shRNA-based anti-BCMA CAR T-cells CYAD-211 recognize and bind to BCMA-overexpressing tumor cells. This may result in a specific cytotoxic T-lymphocyte (CTL)-mediated killing of BCMA-expressing tumor cells. BCMA, a receptor for both a proliferation-inducing ligand (APRIL) and B-cell activating factor (BAFF), is a member of the tumor necrosis factor receptor superfamily (TNFRSF) and plays a key role in plasma cell survival. BCMA is found on the surfaces of plasma cells and overexpressed on malignant plasma cells. The downregulation of the expression of the TCR CD3zeta subunit by shRNA prevents the potential induction of graft-versus-host disease (GvHD) by the donor T-cells."], "t": []}], "preferred_name": "Allogeneic shRNA-based Anti-BCMA CAR T-cells CYAD-211", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5186830", "l": "Myelocytes | Fetus | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Myelocytes | Fetus | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5856153", "l": "HER2-targeted Hypoxia-stimulated CAR T Cells", "d": [], "t": []}, {"i": "NCIT:C200187", "l": "HER2-targeted Hypoxia-stimulated CAR T Cells", "d": ["A preparation of T-lymphocytes that have been genetically modified to express a hypoxia-stimulated chimeric antigen receptor (CAR) targeting the tumor-associated antigen (TAA) human epidermal growth factor receptor 2 (HER2; ErbB2; HER-2), with potential immunostimulating and antineoplastic activities. Upon administration, HER2-targeted hypoxia-stimulated CAR T cells target and bind to HER2-expressing tumor cells, thereby inducing selective toxicity in HER2-expressing tumor cells. HER2 is overexpressed in a variety of cancer cell types and is associated with increased tumor cell proliferation. Hypoxia-stimulated CAR may improve the expansion and survival of the CAR T cells in the hypoxic tumor microenvironment (TME)."], "t": []}], "preferred_name": "HER2-targeted Hypoxia-stimulated CAR T Cells", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "CL:0002081", "l": "type II cell of carotid body", "d": ["This cell resembles a glia cell, express the glial marker S100 and act as a supporting cell to type I cell. This cell is located in a small cluster of type I and type II cells near the fork of the carotid artery."], "t": []}, {"i": "UMLS:C2331667", "l": "Type II of carotid body", "d": [], "t": []}], "preferred_name": "type II cell of carotid body", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5854522", "l": "Autologous Anti-LGR5 CAR-T Cells CNA3103", "d": [], "t": []}, {"i": "NCIT:C200325", "l": "Autologous Anti-LGR5 CAR-T Cells CNA3103", "d": ["A preparation of autologous T-lymphocytes transduced to express a chimeric antigen receptor (CAR) targeting the cancer stem cell (CSC) marker leucine-rich repeat-containing G-protein coupled receptor 5 (LGR5), with potential  immunomodulating and antineoplastic activities. Upon administration, the autologous anti-LGR5 CAR-T cells CNA3103 selectively target, binds to and lyse LGR5-expressing tumor cells.  LGR5, a member of the Wnt signaling pathway, is overexpressed on certain cancer cells; it plays a key role in CSC proliferation and survival, tumor initiation, growth, and metastasis. Its expression is linked to poor survival and poor patient response to therapy. CNA3103 contains the antigen-biding domain of the humanized monoclonal LGR5 antibody BNC101."], "t": []}], "preferred_name": "Autologous Anti-LGR5 CAR-T Cells CNA3103", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1689938", "l": "Erythrocyte component of blood", "d": [], "t": []}, {"i": "SNOMEDCT:418525009", "l": "", "d": [], "t": []}], "preferred_name": "Erythrocyte component of blood", "taxa": []}
{"type": "biolink:Cell", "ic": 79.64650900338474, "identifiers": [{"i": "CL:0010007", "l": "His-Purkinje system cell", "d": ["Any cell that is part of some His-Purkinje system."], "t": []}], "preferred_name": "His-Purkinje system cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5163558", "l": "Epithelial cells.squamous | Urine sediment | Urinalysis", "d": [], "t": []}], "preferred_name": "Epithelial cells.squamous | Urine sediment | Urinalysis", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5446533", "l": "Autologous PD1-knockout CD19-specific CAR T Cells", "d": [], "t": []}, {"i": "NCIT:C175452", "l": "Autologous PD1-knockout CD19-specific CAR T Cells", "d": ["A preparation of autologous CD4+ and CD8+ T-lymphocytes gene-edited to integrate a chimeric antigen receptor (CAR) targeting the tumor-associated antigen (TAA) CD19 and to eliminate the programmed cell death 1 (PD-1; PDCD1; CD279; programmed death-1) gene, with potential immunomodulating and antineoplastic activities. Upon administration, autologous PD1-knockout CD19-specific CAR T cells specifically target and bind to CD19-expressing tumor cells, thereby selectively lysing CD19-expressing tumor cells. CD19 antigen is a B-cell specific cell surface antigen overexpressed in B-cell lineage malignancies. Expression of PD-1, an inhibitory receptor expressed on activated T-cells, plays a key role in CTL suppression, T-cell exhaustion and CTL apoptosis. PD-1 knockout may abrogate T-cell exhaustion and increase T-cell activity and cytotoxicity."], "t": []}], "preferred_name": "Autologous PD1-knockout CD19-specific CAR T Cells", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0000987", "l": "IgA plasma cell", "d": ["A fully differentiated plasma cell that secretes IgA."], "t": []}], "preferred_name": "IgA plasma cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C2322975", "l": "Radial astrocyte", "d": [], "t": []}], "preferred_name": "Radial astrocyte", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1267948", "l": "Lymphocyte positive for CD56 antigen", "d": [], "t": []}, {"i": "SNOMEDCT:116732008", "l": "", "d": [], "t": []}], "preferred_name": "Lymphocyte positive for CD56 antigen", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4322185", "l": "Epithelial cell of exocervix", "d": [], "t": []}], "preferred_name": "Epithelial cell of exocervix", "taxa": []}
{"type": "biolink:Cell", "ic": 79.64650900338474, "identifiers": [{"i": "UMLS:C1708911", "l": "Malignant Spindle-Shaped Fibroblast", "d": [], "t": []}, {"i": "NCIT:C49021", "l": "Malignant Spindle-Shaped Fibroblast", "d": [], "t": []}], "preferred_name": "Malignant Spindle-Shaped Fibroblast", "taxa": []}
{"type": "biolink:Cell", "ic": 86.30756602822301, "identifiers": [{"i": "CL:0000693", "l": "neurogliaform cell", "d": ["An interneuron that has spider-like appearance with a small round soma, a large number (7-10) of short, smooth, or slightly beaded primary dendrites that give rise to only a few secondary branches, and a branched axon that establishes a dense axonal mesh with thin shafts."], "t": []}], "preferred_name": "neurogliaform cell", "taxa": []}
{"type": "biolink:Cell", "ic": 80.61184433509295, "identifiers": [{"i": "CL:0002495", "l": "fetal cardiomyocyte", "d": ["A fetal and neonatal heart cell that undergoes proliferation and is not yet terminally differentiated into a binucleate or a multinucleate cardiac myocyte."], "t": []}], "preferred_name": "fetal cardiomyocyte", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1440338", "l": "CD62E Cells", "d": [], "t": []}, {"i": "SNOMEDCT:1372915008", "l": "", "d": [], "t": []}], "preferred_name": "CD62E Cells", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5157449", "l": "CD3+CD56+ cells | Body fluid | Cell markers", "d": [], "t": []}], "preferred_name": "CD3+CD56+ cells | Body fluid | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0002545", "l": "thoracic aorta endothelial cell", "d": ["An endothelial cell that is part of the thoracic endothelium."], "t": []}], "preferred_name": "thoracic aorta endothelial cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C0225699", "l": "Type-I Pneumocytes", "d": [], "t": []}, {"i": "NCIT:C13144", "l": "Alveolar Cell Type I", "d": ["A squamous cell that forms the inner lining of the alveoli and is distinguished by its greatly attenuated cytoplasm and paucity of organelles."], "t": []}, {"i": "SNOMEDCT:34826000", "l": "", "d": [], "t": []}], "preferred_name": "Type-I Pneumocytes", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C6021986", "l": "Leukocytes | Wound shallow | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Leukocytes | Wound shallow | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0427529", "l": "Smear cell", "d": [], "t": []}, {"i": "SNOMEDCT:250288005", "l": "", "d": [], "t": []}], "preferred_name": "Smear cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C6022186", "l": "Epithelial cells | Wound shallow | Urinalysis", "d": [], "t": []}], "preferred_name": "Epithelial cells | Wound shallow | Urinalysis", "taxa": []}
{"type": "biolink:Cell", "ic": 92.76600187037766, "identifiers": [{"i": "UMLS:C4727588", "l": "Neoplastic Corticotroph Cell with Abundant Secretory Granules", "d": [], "t": []}, {"i": "NCIT:C154337", "l": "Neoplastic Corticotroph Cell with Abundant Secretory Granules", "d": ["A neoplastic basophilic PAS-positive and ACTH-positive cell with an abundance of secretory granules seen at the ultrastructural level."], "t": []}], "preferred_name": "Neoplastic Corticotroph Cell with Abundant Secretory Granules", "taxa": []}
{"type": "biolink:Cell", "ic": 87.18682603146104, "identifiers": [{"i": "UMLS:C1513985", "l": "Neoplastic Histiocyte-Like Cell", "d": [], "t": []}, {"i": "NCIT:C36961", "l": "Neoplastic Histiocyte-Like Cell", "d": [], "t": []}], "preferred_name": "Neoplastic Histiocyte-Like Cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1440368", "l": "CD91+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:1372942009", "l": "", "d": [], "t": []}], "preferred_name": "CD91+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4477473", "l": "human cord blood hematopoietic progenitor cell 500000000 in 25 mL INTRAVENOUS INJECTION, SUSPENSION [CLEVECORD]", "d": [], "t": []}], "preferred_name": "human cord blood hematopoietic progenitor cell 500000000 in 25 mL INTRAVENOUS INJECTION, SUSPENSION [CLEVECORD]", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5784990", "l": "Autologous Anti-ROR1 CAR-mbIL15-Safety Switch/Intrinsic PD-1 Blockade T-cells PRGN-3007", "d": [], "t": []}, {"i": "NCIT:C192220", "l": "Autologous Anti-ROR1 CAR-mbIL15-Safety Switch/Intrinsic PD-1 Blockade T-cells PRGN-3007", "d": ["A preparation of autologous T-lymphocytes engineered to express, using a single non-viral multicistronic transposon plasmid, a chimeric antigen receptor (CAR) targeting the receptor tyrosine kinase-like orphan receptor 1 (ROR1), membrane-bound IL-15 (mbIL15), a kill switch and an intrinsic programmed death 1 (PD-1; PDCD1; CD279; programmed cell death-1) checkpoint blockade, with potential immunomodulatory and antineoplastic activities. After isolation, non-viral gene transfer, and expansion in culture, the autologous anti-ROR1 CAR-mbIL15-safety switch/intrinsic PD-1 blockade T-cells PRGN-3007 are reintroduced into the patient and are directed to tumor cells expressing ROR1, which may result in a selective toxicity against, and lysis of ROR1-expressing tumor cells. ROR1 is expressed during embryogenesis and upregulated in certain tumor types with minimal expression in healthy adult tissues. High levels of ROR1 expression often correlate with poor prognosis. PD-1, an immune checkpoint receptor expressed on T-cells, plays a key role in tumor immune evasion by binding to its ligand programmed death ligand 1 (PD-L1; cluster of differentiation 274; CD274; programmed cell death-1 ligand 1) expressed on tumor cells. By removing PD-1 from T-cells, PD-1-mediated signaling is halted which may decrease T-cell exhaustion and may enhance T-cell activity against ROR1-expressing tumor cells. mbIL15 enhances T-cell expansion and persistence through sustained IL-15 signaling. The kill switch allows for improved safety as it can promote selective elimination of the CAR-T cells upon treatment with the kill switch activator antibody."], "t": []}], "preferred_name": "Autologous Anti-ROR1 CAR-mbIL15-Safety Switch/Intrinsic PD-1 Blockade T-cells PRGN-3007", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4047018", "l": "early colonocyte", "d": ["An enterocyte that is part of the colon, in the early stages of differentiation, located in the intestinal crypt-villus axis."], "t": []}], "preferred_name": "early colonocyte", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1440234", "l": "CD102+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:725326002", "l": "", "d": [], "t": []}], "preferred_name": "CD102+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5154514", "l": "Basophils+Eosinophils+Monocytes | Blood | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Basophils+Eosinophils+Monocytes | Blood | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0000200", "l": "touch receptor cell", "d": ["Any neuron that is capable of some detection of mechanical stimulus involved in sensory perception of touch."], "t": []}], "preferred_name": "touch receptor cell", "taxa": []}
{"type": "biolink:Cell", "ic": 92.76600187037766, "identifiers": [{"i": "CL:4030051", "l": "nucleus accumbens shell and olfactory tubercle D1 medium spiny neuron", "d": ["A DRD1-expressing medium spiny neuron that is part of a nucleus accumbens shell or olfactory tubercle."], "t": []}], "preferred_name": "nucleus accumbens shell and olfactory tubercle D1 medium spiny neuron", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1519122", "l": "SA03", "d": [], "t": []}, {"i": "NCIT:C20266", "l": "SA03", "d": ["Provider: Goteborg University, Goteborg, Sweden. No information from provider. This cell line meets the criteria for the use of human embryonic stem cells by federally funded researchers."], "t": []}], "preferred_name": "SA03", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4307111", "l": "OEC NN_1 A330076C08Rik olfactory ensheathing cell (Mmus)", "d": ["A olfactory ensheathing cell of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Apod (Mmus), Mybpc1 (Mmus), Syk (Mmus). It is distinguished from other OEC cells by expression of A330076C08Rik. These cells are located in the Olfactory areas, brain , in or close to the regions: olfactory nerve layer of main olfactory bulb, Main olfactory bulb . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5291 OEC NN_1."], "t": []}], "preferred_name": "OEC NN_1 A330076C08Rik olfactory ensheathing cell (Mmus)", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1515168", "l": "TNF Transduced TIL", "d": [], "t": []}, {"i": "NCIT:C29482", "l": "TNF Transduced TIL", "d": ["A preparation of autologous tumor-infiltrating lymphocytes (TILs) that have been transduced with a retroviral vector encoding the gene for tumor necrosis factor (TNF), a cytokine with anti-angiogenic and cytotoxic activity.  Following genetic modification, the lymphocytes are returned to the patient, infiltrate the tumor site, and deliver TNF directly to the tumor site, thereby exerting a specific antitumor effect, and avoiding TNF-related systemic toxicity. (NCI04)"], "t": []}], "preferred_name": "TNF Transduced TIL", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5447453", "l": "Autologous Anti-HER2 CAR Macrophages CT-0508", "d": [], "t": []}, {"i": "NCIT:C176824", "l": "Autologous Anti-HER2 CAR Macrophages CT-0508", "d": ["A preparation of autologous macrophages transduced with the adenoviral vector Ad5f35 to express a chimeric antigen receptor (CAR) targeting the tumor-associated antigen (TAA) human epidermal growth factor receptor 2 (EGFR2; HER2; ErbB2), with potential immunostimulatory and antineoplastic activities. Upon administration, autologous anti-HER2 CAR Macrophages (CAR-M) CT-0508 specifically recognize and bind to HER2-expressing tumor cells, resulting in the phagocytosis of HER2-expressing tumor cells. CAR-M CT-0508 maintain the pro-inflammatory, anti-tumor M1 phenotype within the human tumor microenvironment (TME). In addition, CAR-M CT-0508 may activate an anti-tumor T-lymphocyte immune response resulting in T-cell-mediated killing of tumor cells. HER2, a receptor tyrosine kinase that is mutated or overexpressed in many tumor cell types, plays an important role in tumor cell proliferation and tumor vascularization."], "t": []}], "preferred_name": "Autologous Anti-HER2 CAR Macrophages CT-0508", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0553711", "l": "Blood band cell", "d": [], "t": []}], "preferred_name": "Blood band cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1512135", "l": "ES06 (cell line)", "d": [], "t": []}, {"i": "NCIT:C20254", "l": "ES06", "d": ["Provider: ES Cell International Pte Ltd., Melbourne, Australia. Information from provider and not independently verified by NIH: Undergoing characterization. This cell line meets the criteria for the use of human embryonic stem cells by federally funded researchers."], "t": []}], "preferred_name": "ES06 (cell line)", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1516898", "l": "Eosinophil Precursor Cell", "d": [], "t": []}, {"i": "NCIT:C41177", "l": "Eosinophil Precursor Cell", "d": [], "t": []}], "preferred_name": "Eosinophil Precursor Cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5157532", "l": "CD4 cells | Blood | Cell markers", "d": [], "t": []}], "preferred_name": "CD4 cells | Blood | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C3652665", "l": "chromium (51Cr) chromate labelled cells", "d": [], "t": []}], "preferred_name": "chromium (51Cr) chromate labelled cells", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C4684836", "l": "Autologous Dendritic Cells Pulsed with MART-1 (26-35) Peptide", "d": [], "t": []}, {"i": "NCIT:C142814", "l": "Autologous Dendritic Cells Pulsed with MART-1 (26-35) Peptide", "d": ["A cell-based vaccine consisting of autologous HLA-A2*0201-restricted dendritic cells (DC), which were derived from patient-harvested adherent peripheral blood monocytes cultured in vitro with granulocyte-macrophage colony-stimulating factor (GM-CSF) and interleukin-4 (IL-4), that were pulsed with a peptide fragment comprised of amino acid residues 26 through 35 of melanoma antigen recognized by T-cells 1 (MART-1 (26-35)), with potential immunostimulatory and antineoplastic activities. Upon intradermal vaccination, autologous DC pulsed with MART-1 (26-35) peptide may stimulate the host immune system to mount a cytotoxic T-lymphocyte immune response against tumor cells expressing MART-1. MART-1, a protein involved in melanosome biogenesis, is overexpressed by melanoma cells. The MART-1 (26-35) peptide is highly immunogenic for the HLA-A2*0201 haplotype."], "t": []}], "preferred_name": "Autologous Dendritic Cells Pulsed with MART-1 (26-35) Peptide", "taxa": []}
{"type": "biolink:Cell", "ic": 67.05067056748027, "identifiers": [{"i": "CL:0000826", "l": "pro-B cell", "d": ["A progenitor cell of the B cell lineage, with some lineage specific activity such as early stages of recombination of B cell receptor genes, but not yet fully committed to the B cell lineage until the expression of PAX5 occurs."], "t": []}], "preferred_name": "pro-B cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4032000", "l": "club-like cell of the urethral epithelium", "d": ["An epithelial cell of the urethra that has an expression profile similar to lung club cells. Club-like cells of the urethra epithelium are similar to lung club cells in their expression of SCGB1A1 and in their enrichment of immunomodulatory programs."], "t": []}], "preferred_name": "club-like cell of the urethral epithelium", "taxa": []}
{"type": "biolink:Cell", "ic": 63.48684274192801, "identifiers": [{"i": "UMLS:C0879438", "l": "Allogeneic Lymphocyte", "d": [], "t": []}, {"i": "NCIT:C13396", "l": "Allogeneic Lymphocyte", "d": ["A cell that is antigenically distinct from other lymphocytes."], "t": []}, {"i": "NCIT:C28676", "l": "Therapeutic Allogeneic Lymphocytes", "d": ["A population of lymphocytes therapeutically administered to a recipient individual who is genetically distinct from a donor of the same species. (NCI04)"], "t": []}], "preferred_name": "Allogeneic Lymphocyte", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5400079", "l": "Adult human mesenchymal stem cells", "d": [], "t": []}], "preferred_name": "Adult human mesenchymal stem cells", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0002079", "l": "pancreatic ductal cell", "d": ["Epithelial cell found in the ducts of the pancreas. This cell type contributes to the high luminal pH."], "t": []}, {"i": "UMLS:C1179554", "l": "Pancreatic ductal cell", "d": [], "t": []}], "preferred_name": "pancreatic ductal cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4030042", "l": "glandular endometrial multiciliated epithelial cell", "d": ["A ciliated cell of the endometrial glandular epithelium. This cell is characterized by the presence of motile cilia on its apical surface."], "t": []}], "preferred_name": "glandular endometrial multiciliated epithelial cell", "taxa": []}
{"type": "biolink:Cell", "ic": 65.41551869876032, "identifiers": [{"i": "CL:4023035", "l": "lateral ganglionic eminence derived neuron", "d": ["A neuron that is derived from a precursor cell in the lateral ganglion eminence."], "t": []}], "preferred_name": "lateral ganglionic eminence derived neuron", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5148041", "l": "CD55 Monocytes", "d": [], "t": []}], "preferred_name": "CD55 Monocytes", "taxa": []}
{"type": "biolink:Cell", "ic": 92.76600187037766, "identifiers": [{"i": "UMLS:C1708875", "l": "Malignant Epithelioid Smooth Muscle Cell", "d": [], "t": []}, {"i": "NCIT:C49127", "l": "Malignant Epithelioid Smooth Muscle Cell", "d": [], "t": []}], "preferred_name": "Malignant Epithelioid Smooth Muscle Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1514067", "l": "Neoplastic Plump Epithelial Cell", "d": [], "t": []}, {"i": "NCIT:C36886", "l": "Neoplastic Plump Epithelial Cell", "d": [], "t": []}], "preferred_name": "Neoplastic Plump Epithelial Cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5157228", "l": "CD1 blasts | Blood | Cell markers", "d": [], "t": []}], "preferred_name": "CD1 blasts | Blood | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4042041", "l": "middle primary motoneuron", "d": ["A type of primary motor neuron located in the middle region of the spinal cord. This primary motor neuron type is characterized by their distinct axonal pathways that innervate the middle trunk muscles."], "t": []}], "preferred_name": "middle primary motoneuron", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5166080", "l": "Granulocytes | Body fluid | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Granulocytes | Body fluid | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0020050", "l": "ascending interneuron of myenteric plexus", "d": ["An interneuron of the myenteric plexus whose axon projects orally (in the ascending direction) along the gut axis. This neuron is immunopositive for choline acetyltransferase (ChAT) and enkephalin (ENK), and forms the excitatory limb of ascending reflex pathways that coordinate peristalsis."], "t": []}], "preferred_name": "ascending interneuron of myenteric plexus", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0684115", "l": "macroblast of Naegeli", "d": [], "t": []}], "preferred_name": "macroblast of Naegeli", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0883208", "l": "Lymphoma cells", "d": [], "t": []}, {"i": "SNOMEDCT:1382197005", "l": "", "d": [], "t": []}], "preferred_name": "Lymphoma cells", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0598089", "l": "established cell line", "d": [], "t": []}], "preferred_name": "established cell line", "taxa": []}
{"type": "biolink:Cell", "ic": 66.91941036331596, "identifiers": [{"i": "CL:0002656", "l": "glandular endometrial unciliated epithelial cell", "d": ["A glandular epithelial cell of the endometrium. Following ovulation, these cells secrete a glycogen-rich substance known as histotroph or uterine milk, which nourishes the embryo if implantation occurs."], "t": []}, {"i": "UMLS:C0524457", "l": "Structure of endometrial glandular cell", "d": [], "t": []}, {"i": "NCIT:C32515", "l": "Endometrial Glandular Cell", "d": ["An epithelial cell lining the endometrial cavity, located in the uterus. These cells proliferate and respond to the cyclic variations of estrogen and progesterone.  They synthesize or transport and secrete substances essential for survival and development of the embryo/fetus and associated extraembryonic membranes."], "t": []}, {"i": "SNOMEDCT:91768008", "l": "", "d": [], "t": []}], "preferred_name": "glandular endometrial unciliated epithelial cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4052047", "l": "late luteal cell", "d": ["A luteal cell that is part of the older, regressing corpus luteum. This cell exhibits increased expression of genes involved in progesterone metabolism - Akr1c18 in mice (Lan et al., 2024), cell cycle arrest, and apoptosis. A late luteal cell contributes to corpus luteum regression and eventual clearance from the ovary through luteolysis."], "t": []}], "preferred_name": "late luteal cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0002219", "l": "anchoring trophoblast", "d": ["A trophoblast found at the junction of the placenta. This cell type makes a unique fibronectin-trophouteronectin junction that helps mediate attachment of the placenta to the uterus. This cell type is also found junction of the chorion layer of the external membranes and the decidua."], "t": []}], "preferred_name": "anchoring trophoblast", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:1000479", "l": "Purkinje myocyte of atrioventricular node", "d": ["A Purkinje myocyte that is part of the atrioventricular node."], "t": []}, {"i": "UMLS:C2337923", "l": "Purkinje myocyte of atrioventricular node", "d": [], "t": []}], "preferred_name": "Purkinje myocyte of atrioventricular node", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4510889", "l": "Blast cell positive for CD7 antigen", "d": [], "t": []}, {"i": "SNOMEDCT:724315001", "l": "", "d": [], "t": []}], "preferred_name": "Blast cell positive for CD7 antigen", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "CL:0000484", "l": "connective tissue type mast cell", "d": ["Mast cell subtype whose granules contain both the serine proteases tryptase and chymase. These cells are primarily found in connective tissue, such as the peritoneal cavity, skin, and intestinal submucosa. Their development is T-cell independent."], "t": []}], "preferred_name": "connective tissue type mast cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1507325", "l": "CD13+CD16+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:1372966003", "l": "", "d": [], "t": []}], "preferred_name": "CD13+CD16+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": 88.20185721311867, "identifiers": [{"i": "CL:2000031", "l": "lateral line ganglion neuron", "d": ["Any neuron that is part of a lateral line ganglion."], "t": []}], "preferred_name": "lateral line ganglion neuron", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5706521", "l": "Allogeneic Natural Killer Cells DVX201", "d": [], "t": []}, {"i": "NCIT:C188962", "l": "Allogeneic Natural Killer Cells DVX201", "d": ["A preparation of allogeneic natural killer (NK) cells, with potential cytolytic and antineoplastic activities. Upon administration, allogeneic NK cells DVX201 may directly lyse cancer cells. These cells also secrete pro-inflammatory cytokines and further stimulate a systemic immune response against cancer cells."], "t": []}], "preferred_name": "Allogeneic Natural Killer Cells DVX201", "taxa": []}
{"type": "biolink:Cell", "ic": 77.17927671370501, "identifiers": [{"i": "CL:0000822", "l": "B-2 B cell", "d": ["A conventional B cell subject to antigenic stimulation and dependent on T cell help and with a distinct surface marker expression pattern from B-1 B cells. These cells are CD43-negative."], "t": []}], "preferred_name": "B-2 B cell", "taxa": []}
{"type": "biolink:Cell", "ic": 64.19204850040359, "identifiers": [{"i": "CL:0000451", "l": "dendritic cell", "d": ["A cell of hematopoietic origin, typically resident in particular tissues, specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation. These cells are lineage negative (CD3-negative, CD19-negative, CD34-negative, and CD56-negative)."], "t": []}, {"i": "UMLS:C0011306", "l": "Dendritic Cells", "d": [], "t": []}, {"i": "NCIT:C12583", "l": "Dendritic Cell", "d": ["Immunocompetent cells of the lymphoid and hemopoietic systems and skin. They function morphologically and phenotypically by presenting or processing antigens, thereby stimulating cellular immunity. They represent the most potent antigen-presenting cells and, therefore, play a critical role in the primary T cell immune response."], "t": []}, {"i": "MESH:D003713", "l": "Dendritic Cells", "d": [], "t": []}], "preferred_name": "dendritic cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:1001099", "l": "kidney efferent arteriole endothelial cell", "d": ["Any endothelial cell that is part of some renal efferent arteriole."], "t": []}], "preferred_name": "kidney efferent arteriole endothelial cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5163728", "l": "Erythrocytes | Urine | Urinalysis", "d": [], "t": []}], "preferred_name": "Erythrocytes | Urine | Urinalysis", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1441349", "l": "Abnormal blood cells.total", "d": [], "t": []}], "preferred_name": "Abnormal blood cells.total", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5163443", "l": "Eosinophils | Peritoneal fluid | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Eosinophils | Peritoneal fluid | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": 68.8717166271425, "identifiers": [{"i": "CL:0000623", "l": "natural killer cell", "d": ["A lymphocyte that can spontaneously kill a variety of target cells without prior antigenic activation via germline encoded activation receptors and also regulate immune responses via cytokine release and direct contact with other cells."], "t": []}, {"i": "UMLS:C0022688", "l": "Natural Killer Cells", "d": [], "t": []}, {"i": "NCIT:C12536", "l": "Natural Killer Cell", "d": ["Natural killer cells are cells that resemble large granular lymphocytes.  They do not express markers of either T or B cell lineage. They are positive for CD16, CD56, and CD 94.  These cells do possess Fc receptors for IgG and can kill target cells using antibody-dependent cell-mediated cytotoxicity. They can also use perforin to kill cells in the absence of antibody and killing may occur without previous sensitization."], "t": []}, {"i": "MESH:D007694", "l": "Killer Cells, Natural", "d": [], "t": []}, {"i": "SNOMEDCT:259717003", "l": "", "d": [], "t": []}], "preferred_name": "natural killer cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C4764038", "l": "Anti-CD38/BCMA CAR T-lymphocytes", "d": [], "t": []}, {"i": "NCIT:C158087", "l": "Anti-CD38/BCMA CAR T-lymphocytes", "d": ["A preparation of T-lymphocytes that have been genetically modified to express a dual-targeted chimeric antigen receptor (CAR) recognizing the tumor-associated antigens (TAAs), cluster of differentiation 38 (CD38) and B-cell maturation antigen (BCMA; tumor necrosis factor receptor superfamily member 17; TNFRSF17), with potential immunostimulating and antineoplastic activities. Upon intravenous administration, the anti-CD38/BCMA CAR T-cells are directed to and induce selective toxicity in both CD38- and BCMA-expressing cells. CD38, a type II transmembrane glycoprotein, is present on various immune cells and hematologic malignancies, and its expression has been correlated with poor prognosis. BCMA is found on the surfaces of plasma cells and is and overexpressed on malignant plasma cells."], "t": []}], "preferred_name": "Anti-CD38/BCMA CAR T-lymphocytes", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5220597", "l": "Leukocyte clumps|Urine/Urine sed", "d": [], "t": []}], "preferred_name": "Leukocyte clumps|Urine/Urine sed", "taxa": []}
{"type": "biolink:Cell", "ic": 92.76600187037766, "identifiers": [{"i": "CL:0002052", "l": "fraction D precursor B cell", "d": ["A pre-B cell that is pre-BCR-negative, and the kappa- and lambda- light immunoglobulin light chain-negative, CD43-low, and is BP-1-positive, CD45R-positive and CD25-positive. This cell type is also described as being AA4-positive, IgM-negative, CD19-positive, CD43-low/negative, and HSA-positive."], "t": []}], "preferred_name": "fraction D precursor B cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1512131", "l": "ES02", "d": [], "t": []}, {"i": "NCIT:C20250", "l": "ES02", "d": ["Provider: ES Cell International Pte Ltd., Melbourne, Australia. Information from provider and not independently verified by NIH: Cells are positive for cell markers Oct-4, SSEA-4, TRA-1-60, GCTM-2, and alkaline phosphatase activity; Cells are negative for cell marker SSEA-1; Give rise to teratomas containing derivatives of three germ layers in SCID mice; Differentiate in vitro into extraembryonic and somatic cell lineages; Neural progenitor cells may be isolated from differentiating ES cell cultures and induced to form mature neurons; Available for distribution. This cell line meets the criteria for the use of human embryonic stem cells by federally funded researchers."], "t": []}], "preferred_name": "ES02", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5177620", "l": "Platelets | Dialysis fluid | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Platelets | Dialysis fluid | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5157443", "l": "CD3+CD4+CD28+HLA DR+ cells | Blood | Cell markers", "d": [], "t": []}], "preferred_name": "CD3+CD4+CD28+HLA DR+ cells | Blood | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5962154", "l": "Autologous Anti-CD19 AbTCR-expressing T-lymphocytes EB103", "d": [], "t": []}, {"i": "NCIT:C209361", "l": "Autologous Anti-CD19 AbTCR-expressing T-lymphocytes EB103", "d": ["A preparation of autologous T-lymphocytes transduced with a lentiviral vector encoding an antibody-T-cell-receptor (AbTCR) composed of a CD19-binding domain derived from an antibody fragment antigen binding (Fab) region and an effector domain derived from human gamma/delta TCR, and a co-stimulatory molecule composed of a CD19-binding domain derived from a single-chain variable fragment (scFv) and a co-stimulatory domain derived from a human co-stimulatory receptor, with potential immunostimulating and antineoplastic activities. Upon administration of the autologous anti-CD19 AbTCR-expressing T-lymphocytes EB103, both the AbTCR moiety and the co-stimulatory molecule recognize and bind to CD-19-expressing tumor cells, resulting in specific T-cell-mediated tumor cell lysis. CD19, a B-cell-specific cell surface antigen, is overexpressed in B-cell lineage malignancies."], "t": []}], "preferred_name": "Autologous Anti-CD19 AbTCR-expressing T-lymphocytes EB103", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1276850", "l": "Entire parathyroid chief cell", "d": [], "t": []}, {"i": "SNOMEDCT:177527004", "l": "", "d": [], "t": []}], "preferred_name": "Entire parathyroid chief cell", "taxa": []}
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{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C2953987", "l": "Type D cell of colon", "d": [], "t": []}], "preferred_name": "Type D cell of colon", "taxa": []}
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{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C3178785", "l": "Adrenergic Neurons", "d": [], "t": []}, {"i": "MESH:D059331", "l": "Adrenergic Neurons", "d": [], "t": []}], "preferred_name": "Adrenergic Neurons", "taxa": []}
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{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C3496264", "l": "B1 cell group", "d": [], "t": []}], "preferred_name": "B1 cell group", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5160255", "l": "Clue cells | XXX | Microbiology", "d": [], "t": []}], "preferred_name": "Clue cells | XXX | Microbiology", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1440394", "l": "Cells.S phase", "d": [], "t": []}], "preferred_name": "Cells.S phase", "taxa": []}
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{"type": "biolink:Cell", "ic": 87.18682603146104, "identifiers": [{"i": "UMLS:C1514202", "l": "Polygonal Brown Fat Cell", "d": [], "t": []}, {"i": "NCIT:C36967", "l": "Polygonal Brown Fat Cell", "d": [], "t": []}], "preferred_name": "Polygonal Brown Fat Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 55.230468567797324, "identifiers": [{"i": "UMLS:C3641722", "l": "Effector T-Lymphocyte", "d": [], "t": []}, {"i": "NCIT:C104083", "l": "Effector T-Lymphocyte", "d": ["A mature T-lymphocyte that has differentiated into a form that can mount an antigen-specific immune response."], "t": []}], "preferred_name": "Effector T-Lymphocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0009065", "l": "tuft cell of anorectum", "d": ["An intestinal tuft cell that is located in the anorectum."], "t": []}], "preferred_name": "tuft cell of anorectum", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0011032", "l": "lysosome-rich enterocyte", "d": ["An enterocyte that possesses a large supranuclear vacuolar system that preferentially internalizes dietary protein via receptor-mediated and fluid-phase endocytosis for intracellular digestion and trans-cellular transport. In zebrafish these cells are located in the posterior region of the mid intestine throughout life. In mammals they are found in the ileum pre-weaning and later are replaced by mature enterocytes."], "t": []}], "preferred_name": "lysosome-rich enterocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C4525597", "l": "Autologous Peripheral Blood Mononuclear Cells", "d": [], "t": []}, {"i": "NCIT:C135058", "l": "Autologous Peripheral Blood Mononuclear Cells", "d": ["A preparation of autologous peripheral blood mononuclear cells (PBMCs)."], "t": []}], "preferred_name": "Autologous Peripheral Blood Mononuclear Cells", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0682525", "l": "W138 cell", "d": [], "t": []}], "preferred_name": "W138 cell", "taxa": []}
{"type": "biolink:Cell", "ic": 37.10409098978309, "identifiers": [{"i": "CL:0011115", "l": "precursor cell", "d": ["A cell that, by division or terminal differentiation, can give rise to other cell types."], "t": []}], "preferred_name": "precursor cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C6049742", "l": "Autologous TIM-4 Chimeric Engulfment Receptor T-cells CER-1236", "d": [], "t": []}, {"i": "NCIT:C215203", "l": "Autologous TIM-4 Chimeric Engulfment Receptor T-cells CER-1236", "d": ["A preparation of autologous T-cells genetically engineered to express a chimeric engulfment receptor (CER) that contains the phosphatidylserine (PS) receptor T-cell immunoglobulin and mucin domain-containing protein 4 (TIM-4) extracellular signaling domain linked to the transmembrane domain of the co-stimulatory signaling protein CD28 and the zeta chain of the TCR/CD3 complex (CD3-zeta) fused to the Toll/interleukin-1 receptor (TIR) domain from Toll-like receptor 2 (TLR-2; TLR2; Toll/Interleukin 1 Receptor-Like 4) (TLR2-TIR) as an additional innate signaling domain to enhance antigen-presenting cell (APC)-function, with potential phagocytic, immunomodulating and antineoplastic activities. Upon administration, autologous TIM-4 CER T-cells CER-1236 target and bind to the phospholipid and TIM-4 ligand (TIM-4-L) phosphatidylserine expressed on tumor cells. This binding induces cytolytic and phagocyte-like engulfment activity of the CER T-cells, thereby killing TIM-4-L expressing tumor cells. Activation of the T-cell signaling domains activate and enhance the cytotoxic T-lymphocyte response against the tumor cells, thereby further killing tumor cells. In addition, the tumor-associated antigens (TAAs) that are leaked from the tumor cells are taken up by CER-1236 and are processed and presented to the immune system through an APC-like presentation, thereby inducing secondary immune responses and activating bystander T-cells. Aberrant TIM-4-L expression is observed on malignant cells of multiple lineages, but its expression is minimal on normal, healthy cells."], "t": []}], "preferred_name": "Autologous TIM-4 Chimeric Engulfment Receptor T-cells CER-1236", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0004223", "l": "AB diffuse-1 amacrine cell", "d": ["A amacrine cell with a small dendritic field and post-synaptic terminals in S1, S2, S3, and S4. AB diffuse-1 amacrine cells have a tent-shaped dendritic arbor and undulate dendrites."], "t": []}], "preferred_name": "AB diffuse-1 amacrine cell", "taxa": []}
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{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C4329333", "l": "Anti-LeY-CAR-transduced Autologous T-Lymphocytes", "d": [], "t": []}, {"i": "NCIT:C132683", "l": "Anti-LeY-CAR-transduced Autologous T-Lymphocytes", "d": ["Genetically modified, autologous T-lymphocytes transduced with a retroviral vector encoding a chimeric antigen receptor (CAR) specific for the tumor-associated antigen (TAA) Lewis-Y (LeY), with potential immunomodulating and antineoplastic activities. Upon intravenous administration, anti-LeY-CAR-transduced autologous T-lymphocytes specifically target and induce selective toxicity in LeY-expressing tumor cells. LeY, a difucosylated carbohydrate antigen, is overexpressed by a variety of cancer cell types."], "t": []}], "preferred_name": "Anti-LeY-CAR-transduced Autologous T-Lymphocytes", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5157352", "l": "CD19+CD27+ cells | Blood | Cell markers", "d": [], "t": []}], "preferred_name": "CD19+CD27+ cells | Blood | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5700424", "l": "Autologous CD34+ HSCs Transduced with LentiGlobin BB305", "d": [], "t": []}], "preferred_name": "Autologous CD34+ HSCs Transduced with LentiGlobin BB305", "taxa": []}
{"type": "biolink:Cell", "ic": 85.53200374075534, "identifiers": [{"i": "CL:1001596", "l": "salivary gland glandular cell", "d": ["Glandular cell of salivary gland. Example: Serous cells, mucous cells, cuboidal epithelial cells of the intercalated ducts, simple cuboidal epithelium of the striated ducts, epithelial cells of excretory ducts."], "t": []}], "preferred_name": "salivary gland glandular cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5157350", "l": "CD19+CD103+ cells | Blood | Cell markers", "d": [], "t": []}], "preferred_name": "CD19+CD103+ cells | Blood | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C6022184", "l": "Epithelial cells | Bronchial | Urinalysis", "d": [], "t": []}], "preferred_name": "Epithelial cells | Bronchial | Urinalysis", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1979086", "l": "Blasts.CD11a", "d": [], "t": []}], "preferred_name": "Blasts.CD11a", "taxa": []}
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{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1956157", "l": "Suppressor T-Lymphocytes, CD8-Positive", "d": [], "t": []}], "preferred_name": "Suppressor T-Lymphocytes, CD8-Positive", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5446774", "l": "Nalotimagene carmaleucel", "d": [], "t": []}, {"i": "NCIT:C175827", "l": "Nalotimagene Carmaleucel", "d": [], "t": []}], "preferred_name": "Nalotimagene carmaleucel", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0028876", "l": "Odontoclasts", "d": [], "t": []}], "preferred_name": "Odontoclasts", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1545529", "l": "Invasive trophoblast", "d": [], "t": []}], "preferred_name": "Invasive trophoblast", "taxa": []}
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{"type": "biolink:Cell", "ic": 83.11065783093733, "identifiers": [{"i": "UMLS:C1522173", "l": "Mouse Astrocyte", "d": [], "t": []}, {"i": "NCIT:C22607", "l": "Mouse Astrocyte", "d": [], "t": []}], "preferred_name": "Mouse Astrocyte", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C2709162", "l": "Mycobacterium tuberculosis A60", "d": [], "t": []}], "preferred_name": "Mycobacterium tuberculosis A60", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5854685", "l": "Ebvallo", "d": [], "t": []}], "preferred_name": "Ebvallo", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C3900004", "l": "Autologous CD171-specific CAR-CD28 zeta-4-1-BB-EGFRt-expressing T Lymphocytes", "d": [], "t": []}, {"i": "NCIT:C119746", "l": "Autologous CD171-specific CAR-CD28 zeta-4-1-BB-EGFRt-expressing T Lymphocytes", "d": ["A preparation of genetically modified autologous human T-lymphocytes transduced with a lentiviral vector expressing a chimeric antigen receptor (CAR) specific for the L1 cell adhesion molecule (L1-CAM/CD171) antigen, and the co-stimulatory signaling domains CD28, 4-1BB (CD137) and CD3 zeta, and a truncated form of the human epidermal growth factor receptor (EGFRt), with potential immunostimulating and antineoplastic activities. Upon re-infusion into the patient, the autologous L1-CAM-specific CAR-CD28 zeta-4-1-BB-EGFRt-expressing T-lymphocytes are directed to and induce selective toxicity in L1-CAM-expressing tumor cells. L1-CAM, a neuronal cell adhesion molecule and member of the L1 protein family, plays a key role in the development of the nervous system; it is overexpressed in various tumor cell types and is associated with increased chemoresistance, tumor progression, migration and metastasis. Devoid of both ligand-binding domains and tyrosine kinase activity, EGFRt facilitates both the detection of the administered T-cells in vivo and the elimination of the modified T-cells following a cetuximab-induced antibody-dependent cellular cytotoxicity (ADCC) response. The co-stimulatory signaling domains enhance both proliferation of T-cells and antitumor activity."], "t": []}], "preferred_name": "Autologous CD171-specific CAR-CD28 zeta-4-1-BB-EGFRt-expressing T Lymphocytes", "taxa": []}
{"type": "biolink:Cell", "ic": 87.18682603146104, "identifiers": [{"i": "UMLS:C1514172", "l": "Pleomorphic Epithelial Cell", "d": [], "t": []}, {"i": "NCIT:C37170", "l": "Pleomorphic Epithelial Cell", "d": [], "t": []}], "preferred_name": "Pleomorphic Epithelial Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 89.40238429118027, "identifiers": [{"i": "CL:0002128", "l": "Tc17 cell", "d": ["A CD8-positive, alpha-beta T cell that has the phenotype CXCR3-negative, CCR6-positive, CCR5-high, CD45RA-negative, and capable of producing IL-17 and some IFNg."], "t": []}], "preferred_name": "Tc17 cell", "taxa": []}
{"type": "biolink:Cell", "ic": 54.45572197173523, "identifiers": [{"i": "CL:0002032", "l": "hematopoietic oligopotent progenitor cell", "d": ["A hematopoietic oligopotent progenitor cell that has the ability to differentiate into limited cell types but lacks lineage cell markers and self renewal capabilities."], "t": []}], "preferred_name": "hematopoietic oligopotent progenitor cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5986016", "l": "Autologous Anti-mesothelin TNhYP218 CAR T-cells", "d": [], "t": []}, {"i": "NCIT:C215093", "l": "Autologous Anti-mesothelin TNhYP218 CAR T-cells", "d": ["A preparation of autologous T-lymphocytes containing primarily naive and stem cell-like memory (scm) T-cells that have been genetically modified to express a chimeric antigen receptor (CAR) specific for the membrane-proximal region of the human tumor-associated antigen (TAA) mesothelin (MSLN), with potential immunomodulating and antineoplastic activities. Upon administration, autologous anti-MSLN TNhYP218 CAR T-cells specifically target the membrane-proximal region of MSLN and kill MSLN-expressing tumor cells. Mesothelin, a cell surface glycoprotein involved in cell adhesion, is overexpressed in a variety of cancer cell types. Targeting the membrane-proximal region of MSLN may increase the killing of tumor cells and improve T-cell persistence. Naive and scm T-cells may exhibit increased persistence and decreased exhaustion."], "t": []}], "preferred_name": "Autologous Anti-mesothelin TNhYP218 CAR T-cells", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4033150", "l": "nodose ganglion TRPV2 neuron", "d": ["A sensory neuron that has the soma located in the nodose ganglion and expresses the marker transient receptor potential vanilloid 2 (TRPV2)."], "t": []}], "preferred_name": "nodose ganglion TRPV2 neuron", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5157440", "l": "CD3+CD4+CD27+CD45RO+CD62L+ cells | Blood | Cell markers", "d": [], "t": []}], "preferred_name": "CD3+CD4+CD27+CD45RO+CD62L+ cells | Blood | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": 89.40238429118027, "identifiers": [{"i": "UMLS:C1519907", "l": "Vacuolated Endothelial Cell", "d": [], "t": []}, {"i": "NCIT:C37091", "l": "Vacuolated Endothelial Cell", "d": [], "t": []}], "preferred_name": "Vacuolated Endothelial Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 83.11065783093733, "identifiers": [{"i": "UMLS:C1706982", "l": "Granulocyte-Monocyte Progenitor Cell", "d": [], "t": []}, {"i": "NCIT:C42766", "l": "Granulocyte-Monocyte Progenitor Cell", "d": ["A primitive, undifferentiated blood cell which can undergo division and give rise to white blood cells in the neutrophil, eosinophil, basophil or monocyte lines."], "t": []}], "preferred_name": "Granulocyte-Monocyte Progenitor Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 90.871710685482, "identifiers": [{"i": "CL:0001023", "l": "Kit-positive, CD34-positive common myeloid progenitor", "d": ["A common myeloid progenitor that is Kit-positive and CD34-positive, Il7ra-negative, and is SCA1-low and Fcgr2-low and Fcgr3-low."], "t": []}], "preferred_name": "Kit-positive, CD34-positive common myeloid progenitor", "taxa": []}
{"type": "biolink:Cell", "ic": 73.98236851641934, "identifiers": [{"i": "UMLS:C1708877", "l": "Malignant Fibrohistiocytic Cell", "d": [], "t": []}, {"i": "NCIT:C49062", "l": "Malignant Fibrohistiocytic Cell", "d": [], "t": []}], "preferred_name": "Malignant Fibrohistiocytic Cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1267940", "l": "Lymphocyte positive for CD49E antigen", "d": [], "t": []}, {"i": "SNOMEDCT:117383004", "l": "", "d": [], "t": []}], "preferred_name": "Lymphocyte positive for CD49E antigen", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5157627", "l": "CD59 Monocytes | Blood | Cell markers", "d": [], "t": []}], "preferred_name": "CD59 Monocytes | Blood | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C2924224", "l": "Cells.CD25+C69+", "d": [], "t": []}], "preferred_name": "Cells.CD25+C69+", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0545677", "l": "Alveolar cell, type 3", "d": [], "t": []}], "preferred_name": "Alveolar cell, type 3", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1370091", "l": "CD11+CD18+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:1372958007", "l": "", "d": [], "t": []}], "preferred_name": "CD11+CD18+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": 87.18682603146104, "identifiers": [{"i": "CL:1001431", "l": "kidney collecting duct principal cell", "d": ["Any renal principal cell that is part of some collecting duct of renal tubule."], "t": []}], "preferred_name": "kidney collecting duct principal cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0009062", "l": "germinal center T cell", "d": ["A specialized type of CD4 positive T cell, the follicular helper T cell (TFH cell), that upregulates CXCR5 expression to enable its follicular localization. These specialised T cells reside in the germinal center of the lymph node."], "t": []}], "preferred_name": "germinal center T cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0301863", "l": "\"U\" lymphocyte", "d": [], "t": []}], "preferred_name": "\"U\" lymphocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 52.95124949037481, "identifiers": [{"i": "CL:0000075", "l": "columnar/cuboidal epithelial cell", "d": ["A columnar/cuboidal epithelial cell is a cell usually found in a two dimensional sheet with a free surface. Columnar/cuboidal epithelial cells take on the shape of a column or cube."], "t": []}], "preferred_name": "columnar/cuboidal epithelial cell", "taxa": []}
{"type": "biolink:Cell", "ic": 92.76600187037766, "identifiers": [{"i": "UMLS:C1514733", "l": "Rat Cell Line", "d": [], "t": []}, {"i": "NCIT:C20222", "l": "Rat Cell Line", "d": [], "t": []}], "preferred_name": "Rat Cell Line", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1254552", "l": "Band Form Leukocytes", "d": [], "t": []}], "preferred_name": "Band Form Leukocytes", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1267922", "l": "Lymphocyte positive for CD42B antigen", "d": [], "t": []}, {"i": "SNOMEDCT:117366008", "l": "", "d": [], "t": []}], "preferred_name": "Lymphocyte positive for CD42B antigen", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "UMLS:C1512035", "l": "Dopaminergic Neurons", "d": [], "t": []}, {"i": "NCIT:C26454", "l": "Dopaminergic Cell", "d": ["A nerve cell that employs dopamine as its neurotransmitter."], "t": []}, {"i": "MESH:D059290", "l": "Dopaminergic Neurons", "d": [], "t": []}], "preferred_name": "Dopaminergic Neurons", "taxa": []}
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{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C2337324", "l": "Glandular cell of prostate", "d": [], "t": []}], "preferred_name": "Glandular cell of prostate", "taxa": []}
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{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:2000096", "l": "fibroblast of the reticular layer of dermis", "d": ["A fibroblast of dermis that resides in the deep reticular layer, characterised by robust extracellular matrix production with high type I collagen deposition forming densely packed, organised fibrillar networks (Ghetti et al., 2018). This cell exhibits pro-fibrotic properties during wound healing, entering wounds early where it proliferates and deposits collagen to restore dermal architecture (Knoedler et al., 2023; McAndrews et al., 2022). It is distinguished from papillary dermal fibroblasts by expression of COL11A1, POSTN, and SPP1 in humans (Wu et al., 2022)."], "t": []}], "preferred_name": "fibroblast of the reticular layer of dermis", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1444185", "l": "Cleidoic ovum part", "d": [], "t": []}], "preferred_name": "Cleidoic ovum part", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C2599203", "l": "Donated egg", "d": [], "t": []}], "preferred_name": "Donated egg", "taxa": []}
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{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0002027", "l": "CD9-positive, CD41-positive megakaryocyte cell", "d": ["A megakaryocyte cell with is CD9-positive and CD41-positive."], "t": []}], "preferred_name": "CD9-positive, CD41-positive megakaryocyte cell", "taxa": []}
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{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0043380", "l": "Y-Chromosome-Bearing Sperm", "d": [], "t": []}], "preferred_name": "Y-Chromosome-Bearing Sperm", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0333824", "l": "Pancake cell", "d": [], "t": []}, {"i": "SNOMEDCT:28789003", "l": "", "d": [], "t": []}], "preferred_name": "Pancake cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1257793", "l": "Lymphatic Endothelial Cells", "d": [], "t": []}], "preferred_name": "Lymphatic Endothelial Cells", "taxa": []}
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{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5157302", "l": "CD135 blasts | XXX | Cell markers", "d": [], "t": []}], "preferred_name": "CD135 blasts | XXX | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5556527", "l": "Autologous CD34+ cells transduced ex vivo with a lentiviral vector (Chim-CD18-WPRE) encoding the ITGB2 gene", "d": [], "t": []}, {"i": "NCIT:C180650", "l": "Marnetegragene Autotemcel", "d": [], "t": []}], "preferred_name": "Autologous CD34+ cells transduced ex vivo with a lentiviral vector (Chim-CD18-WPRE) encoding the ITGB2 gene", "taxa": []}
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{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C2325162", "l": "Primary afferent neuron", "d": [], "t": []}], "preferred_name": "Primary afferent neuron", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4696640", "l": "CD4+CD25-CD127+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:1373277009", "l": "", "d": [], "t": []}], "preferred_name": "CD4+CD25-CD127+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5571734", "l": "Acanthocytes|Urine/Urine sed", "d": [], "t": []}], "preferred_name": "Acanthocytes|Urine/Urine sed", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C2713244", "l": "Pooled platelet concentrate", "d": [], "t": []}], "preferred_name": "Pooled platelet concentrate", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0000879", "l": "meningeal macrophage", "d": ["A border associated macrophage that is part of a meninx. This macrophage type is elongated and amoeboid spindle-shaped with limited mobility. This macrophage is highly phagocytic, expresses scavenger receptors, has dynamic protrusions and extends its processes during inflammation."], "t": []}], "preferred_name": "meningeal macrophage", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0882808", "l": "Cell positive for CD19 antigen", "d": [], "t": []}, {"i": "SNOMEDCT:116753004", "l": "", "d": [], "t": []}], "preferred_name": "Cell positive for CD19 antigen", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1831954", "l": "Allogeneic Epstein-Barr Virus-Specific Cytotoxic T-Lymphocytes", "d": [], "t": []}, {"i": "NCIT:C62769", "l": "Allogeneic Epstein-Barr Virus-Specific Cytotoxic T-Lymphocytes", "d": ["A preparation of allogeneic Epstein-Barr virus (EBV) specific cytotoxic T-lymphocytes (CTL) with potential antineoplastic activity. Upon administration, the allogeneic EBV-specific CTLs are either harvested from a donor with an EBV-positive tumor or are donor CTLs activated against EBV-specific antigens ex vivo. Administration into a patient exerts a CTL response against EBV-positive tumor cells or EBV-infected cells. This results in cell lysis and inhibition of cancer cell proliferation. EBV, a ubiquitous human herpes virus, is associated with various malignancies, including nasopharyngeal carcinoma, Hodgkin disease, non-Hodgkin lymphoma, and other lymphomas."], "t": []}], "preferred_name": "Allogeneic Epstein-Barr Virus-Specific Cytotoxic T-Lymphocytes", "taxa": []}
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{"type": "biolink:Cell", "ic": 79.35380886648232, "identifiers": [{"i": "UMLS:C1517724", "l": "Large Atypical Platelet", "d": [], "t": []}, {"i": "NCIT:C37039", "l": "Large Atypical Platelet", "d": [], "t": []}], "preferred_name": "Large Atypical Platelet", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5174626", "l": "Neutrophils | Urine | Urinalysis", "d": [], "t": []}], "preferred_name": "Neutrophils | Urine | Urinalysis", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4072017", "l": "agouti-related protein expressing neuron", "d": ["A GABAergic neuron located in the arcuate nucleus of the hypothalamus that expresses agouti-related protein (AgRP). This neuron can coexpress AgRP, GABA, and neuropeptide Y (NPY) in mice, and plays a key role in integrating metabolic signals. It is activated by hunger-related hormones such as ghrelin and inhibited by satiety signals like leptin."], "t": []}], "preferred_name": "agouti-related protein expressing neuron", "taxa": []}
{"type": "biolink:Cell", "ic": 72.11981073685999, "identifiers": [{"i": "CL:0002676", "l": "neural crest derived neuroblast", "d": ["A neuroblast derived from a neural crest cell."], "t": []}], "preferred_name": "neural crest derived neuroblast", "taxa": []}
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{"type": "biolink:Cell", "ic": 90.871710685482, "identifiers": [{"i": "UMLS:C1522059", "l": "Balloon Nevus Cell", "d": [], "t": []}, {"i": "NCIT:C36863", "l": "Balloon Nevus Cell", "d": [], "t": []}], "preferred_name": "Balloon Nevus Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0009048", "l": "anorectum macrophage", "d": ["A macrophage that is located in the anorectum."], "t": []}], "preferred_name": "anorectum macrophage", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C3826603", "l": "Cell metabolism", "d": [], "t": []}], "preferred_name": "Cell metabolism", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0228008", "l": "Primary spermatocyte", "d": [], "t": []}, {"i": "SNOMEDCT:49904001", "l": "", "d": [], "t": []}], "preferred_name": "Primary spermatocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5854452", "l": "Autologous Anti-ROR1 CAR-T Cells ONCT-808", "d": [], "t": []}, {"i": "NCIT:C199660", "l": "Autologous Anti-ROR1 CAR-T Cells ONCT-808", "d": ["A preparation of autologous T-lymphocytes transduced with a lentiviral vector to express a chimeric antigen receptor (CAR) targeting the receptor tyrosine kinase-like orphan receptor 1 (ROR1; neurotrophic tyrosine kinase receptor-related 1; NTRKR1), with potential immunomodulatory and antineoplastic activities. After isolation, transduction, and expansion in culture, the autologous anti-ROR1 CAR-T cells ONCT-808 are reintroduced into the patient and are directed to tumor cells expressing ROR1, which may result in a selective toxicity against, and lysis of ROR1-expressing tumor cells. ROR1 is expressed during embryogenesis and upregulated in certain tumor types. High levels of ROR1 expression often correlate with poor prognosis."], "t": []}], "preferred_name": "Autologous Anti-ROR1 CAR-T Cells ONCT-808", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4042878", "l": "Embryonic Germ Cells", "d": [], "t": []}, {"i": "MESH:D000066473", "l": "Embryonic Germ Cells", "d": [], "t": []}], "preferred_name": "Embryonic Germ Cells", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5181333", "l": "Spermatogonia | Semen | Fertility testing", "d": [], "t": []}], "preferred_name": "Spermatogonia | Semen | Fertility testing", "taxa": []}
{"type": "biolink:Cell", "ic": 89.40238429118027, "identifiers": [{"i": "CL:0000001", "l": "primary cultured cell", "d": ["A cultured cell that is freshly isolated from a organismal source, or derives in culture from such a cell prior to the culture being passaged."], "t": []}], "preferred_name": "primary cultured cell", "taxa": []}
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{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0002266", "l": "type D cell of small intestine", "d": ["A type D cell of the small intestine."], "t": []}, {"i": "UMLS:C2950850", "l": "Type D cell of small intestine", "d": [], "t": []}], "preferred_name": "type D cell of small intestine", "taxa": []}
{"type": "biolink:Cell", "ic": 88.20185721311867, "identifiers": [{"i": "UMLS:C0229545", "l": "Pituicyte", "d": [], "t": []}, {"i": "NCIT:C45919", "l": "Pituicyte", "d": ["A cell of the neural lobe of the hypophysis. It has long branching processes and resembles neuroglia. It secretes antidiuretic hormone."], "t": []}, {"i": "SNOMEDCT:29708002", "l": "", "d": [], "t": []}], "preferred_name": "Pituicyte", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0002468", "l": "Gr1-low myeloid suppressor cell", "d": ["A myeloid suppressor cell that is Gr1-low and CD11c-positive."], "t": []}], "preferred_name": "Gr1-low myeloid suppressor cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1522099", "l": "Mouse Lymphoblast", "d": [], "t": []}, {"i": "NCIT:C22571", "l": "Mouse Lymphoblast", "d": [], "t": []}], "preferred_name": "Mouse Lymphoblast", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C3899032", "l": "Genetically Engineered NY-ESO-1-specific T Lymphocytes", "d": [], "t": []}, {"i": "NCIT:C116846", "l": "Genetically Engineered NY-ESO-1-specific T Lymphocytes", "d": ["A preparation of human T-lymphocytes recognizing the tumor-associated antigen (TAA), cancer/testis antigen 1 (NY-ESO-1), with potential immunostimulating and antineoplastic activities. Genetically engineered NY-ESO-1-specific T-lymphocytes target tumor cells expressing the NY-ESO-1 antigen, resulting in tumor cell lysis. NY-ESO-1, an antigen found in normal testis, is overexpressed on the surface of various tumor cell types."], "t": []}], "preferred_name": "Genetically Engineered NY-ESO-1-specific T Lymphocytes", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5556428", "l": "Allogeneic AdV/CMV/EBV-specific T-lymphocytes", "d": [], "t": []}, {"i": "NCIT:C180509", "l": "Allogeneic AdV/CMV/EBV-specific T-lymphocytes", "d": ["A preparation of human leukocyte antigen (HLA)-matched or HLA-mismatched, allogeneic CD4+ and CD8+ T-lymphocytes, ex vivo incubated with synthetic peptides of the viral antigens of the three human viruses adenovirus (AdV), cytomegalovirus (CMV) and Epstein-Barr virus (EBV), with potential antiviral activity. Upon administration of the allogeneic AdV/CMV/EBV-specific T-lymphocytes after allogeneic hematopoietic stem cell transplantation (HSCT), these T-lymphocytes may kill AdV, CMV, and/or EBV-infected cells, and may prevent or reduce the severity of viral infections by these pathogens."], "t": []}], "preferred_name": "Allogeneic AdV/CMV/EBV-specific T-lymphocytes", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:2000060", "l": "placental villous trophoblast", "d": ["A trophoblast of placental villi.  These cells fuse to form synctial  trophoplast - the placental side of the interface between the placenta and maternal blood sinusoids in the decidua."], "t": []}], "preferred_name": "placental villous trophoblast", "taxa": []}
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{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1520026", "l": "Visceral Afferent Neuron", "d": [], "t": []}, {"i": "NCIT:C33877", "l": "Visceral Afferent Neuron", "d": ["A cell that conducts a nerve impulse that originated at a receptor in one of the interior organs of the one of the three cavities of the body and proceeds towards the central nervous system."], "t": []}], "preferred_name": "Visceral Afferent Neuron", "taxa": []}
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{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "UMLS:C1514437", "l": "Primitive Mesenchymal Round Cell", "d": [], "t": []}, {"i": "NCIT:C36910", "l": "Primitive Mesenchymal Round Cell", "d": [], "t": []}], "preferred_name": "Primitive Mesenchymal Round Cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1440253", "l": "CD126+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:1372832008", "l": "", "d": [], "t": []}], "preferred_name": "CD126+ cell", "taxa": []}
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{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:1000340", "l": "enterocyte of epithelium proper of duodenum", "d": ["An enterocyte that is part of the epithelium proper of duodenum."], "t": []}, {"i": "UMLS:C2327156", "l": "Enterocyte of epithelium proper of duodenum", "d": [], "t": []}], "preferred_name": "enterocyte of epithelium proper of duodenum", "taxa": []}
{"type": "biolink:Cell", "ic": 66.91941036331596, "identifiers": [{"i": "UMLS:C1514113", "l": "Neoplastic Thyroid Gland Follicular Cell", "d": [], "t": []}, {"i": "NCIT:C36835", "l": "Neoplastic Thyroid Gland Follicular Cell", "d": [], "t": []}], "preferred_name": "Neoplastic Thyroid Gland Follicular Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5854460", "l": "Allogeneic CRISPR-Cas9 Engineered Anti-CD70 CAR-T Cells CTX131", "d": [], "t": []}, {"i": "NCIT:C200041", "l": "Allogeneic CRISPR-Cas9 Engineered Anti-CD70 CAR-T Cells CTX131", "d": ["A preparation of human allogeneic T-lymphocytes gene-edited with the clustered regularly interspaced short palindromic repeats (CRISPR)-Cas9 nuclease complex to disrupt expression of endogenous TCR and major histocompatibility complex (MHC) class I molecules and modified to express a chimeric antigen receptor (CAR) specific for the tumor-associated antigen (TAA) human cluster of differentiation 70 (CD70), with potential immunostimulating and antineoplastic activities. Upon introduction into the patient, the allogeneic CRISPR-Cas9 engineered anti-CD70 CAR T-cells CTX131 recognize and bind to CD70-overexpressing tumor cells. This may result in a specific cytotoxic T-lymphocyte (CTL)-mediated killing of CD70-positive tumor cells. CD70, the ligand for the costimulatory receptor CD27 and a member of the tumor necrosis factor (TNF) family, is found on the surfaces of various types of cancer cells. Disruption of endogenous TCR prevents graft-versus-host disease (GvHD); the disruption of MHC class I molecules increases the persistence of the CAR T-cells."], "t": []}], "preferred_name": "Allogeneic CRISPR-Cas9 Engineered Anti-CD70 CAR-T Cells CTX131", "taxa": []}
{"type": "biolink:Cell", "ic": 69.74265740139907, "identifiers": [{"i": "CL:0011110", "l": "histaminergic neuron", "d": ["Neuron that secretes histamine."], "t": []}], "preferred_name": "histaminergic neuron", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1267986", "l": "Lymphocyte positive for CD99 antigen", "d": [], "t": []}, {"i": "SNOMEDCT:117426008", "l": "", "d": [], "t": []}], "preferred_name": "Lymphocyte positive for CD99 antigen", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5853682", "l": "allogeneic CRISPR/Cas9 genome-edited hematopoietic stem and progenitor cell (HSPC) therapy product lacking the CD33 protein", "d": [], "t": []}], "preferred_name": "allogeneic CRISPR/Cas9 genome-edited hematopoietic stem and progenitor cell (HSPC) therapy product lacking the CD33 protein", "taxa": []}
{"type": "biolink:Cell", "ic": 46.2394034523302, "identifiers": [{"i": "CL:0000498", "l": "inhibitory interneuron", "d": ["An interneuron (also called relay neuron, association neuron or local circuit neuron) is a multipolar neuron which connects afferent neurons and efferent neurons in neural pathways. Like motor neurons, interneuron cell bodies are always located in the central nervous system (CNS)."], "t": []}, {"i": "UMLS:C0682694", "l": "Inhibitory interneuron", "d": [], "t": []}], "preferred_name": "inhibitory interneuron", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0333843", "l": "Myeloma cell", "d": [], "t": []}, {"i": "SNOMEDCT:64446007", "l": "", "d": [], "t": []}], "preferred_name": "Myeloma cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0003031", "l": "M3-ON retinal ganglion cell", "d": ["A monostratified retinal ganglion cell that has post synaptic terminals in sublaminar layer S4 and is depolarized by illumination of its receptive field center."], "t": []}], "preferred_name": "M3-ON retinal ganglion cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4023066", "l": "horizontal pyramidal neuron", "d": ["A pyramidal neuron which has an apical tree which is oriented parallel to the pia. This is unlike typical pyramidal neurons which have its apical dendrite aligned vertically."], "t": []}], "preferred_name": "horizontal pyramidal neuron", "taxa": []}
{"type": "biolink:Cell", "ic": 69.94527858408269, "identifiers": [{"i": "CL:0000107", "l": "autonomic neuron", "d": ["A neuron whose cell body is within an autonomic ganglion."], "t": []}], "preferred_name": "autonomic neuron", "taxa": []}
{"type": "biolink:Cell", "ic": 67.36751988375978, "identifiers": [{"i": "CL:0000312", "l": "keratinocyte", "d": ["An epithelial cell of stratified squamous tissues, including skin, oral mucosa (Hiroshima et al., 2011), and esophagus (Whelan et al., 2018), that produces keratin proteins and secretes antimicrobial peptides to form a resilient barrier against environmental damage, dehydration, pathogens, and microbial invasion. It undergoes successive stages of differentiation marked by changes in keratin expression, supporting tissue integrity, wound repair, and contributing to immune defense."], "t": []}, {"i": "UMLS:C0022567", "l": "keratinocyte", "d": [], "t": []}, {"i": "NCIT:C12589", "l": "Keratinocyte", "d": ["The keratin-producing cells of the epidermis.  They are the predominant cells of the epidermis that form in the deep basal layer of the stratified epithelium of the epidermis.  They gradually migrate upward to the cornified layer of the epidermis undergoing characteristic changes."], "t": []}, {"i": "MESH:D015603", "l": "Keratinocytes", "d": [], "t": []}, {"i": "SNOMEDCT:74447004", "l": "", "d": [], "t": []}], "preferred_name": "keratinocyte", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C2335490", "l": "Cranial parasympathetic ganglion neuron", "d": [], "t": []}], "preferred_name": "Cranial parasympathetic ganglion neuron", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5216248", "l": "Lymphocytes.variant|NCnc|Pt|Body fld", "d": [], "t": []}], "preferred_name": "Lymphocytes.variant|NCnc|Pt|Body fld", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1510808", "l": "Adipocyte with Nuclear Atypia", "d": [], "t": []}, {"i": "NCIT:C36978", "l": "Adipocyte with Nuclear Atypia", "d": [], "t": []}], "preferred_name": "Adipocyte with Nuclear Atypia", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5911037", "l": "Lenmeldy", "d": [], "t": []}], "preferred_name": "Lenmeldy", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1267889", "l": "Lymphoblast positive for CD20 antigen", "d": [], "t": []}, {"i": "SNOMEDCT:117565008", "l": "", "d": [], "t": []}], "preferred_name": "Lymphoblast positive for CD20 antigen", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5959093", "l": "Autologous Tumor Infiltrating Lymphocytes BST02", "d": [], "t": []}, {"i": "NCIT:C205438", "l": "Autologous Tumor Infiltrating Lymphocytes BST02", "d": ["A preparation of autologous tumor infiltrating lymphocytes (TILs) derived from the patient's resected tumor and expanded ex vivo, with potential immunomodulating and antineoplastic activities. Upon administration back into the patient, the autologous TILs BST02 specifically recognize and kill the patient's tumor cells."], "t": []}], "preferred_name": "Autologous Tumor Infiltrating Lymphocytes BST02", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5418107", "l": "Autologous CD19-targeted CAR T Cells CC-97540", "d": [], "t": []}], "preferred_name": "Autologous CD19-targeted CAR T Cells CC-97540", "taxa": []}
{"type": "biolink:Cell", "ic": 85.53200374075534, "identifiers": [{"i": "CL:0000702", "l": "R5 photoreceptor cell", "d": [], "t": []}], "preferred_name": "R5 photoreceptor cell", "taxa": []}
{"type": "biolink:Cell", "ic": 71.83956976897835, "identifiers": [{"i": "CL:4023009", "l": "extratelencephalic-projecting glutamatergic cortical neuron", "d": ["A glutamatergic neuron located in the cerebral cortex that projects to structures not derived from telencephalon."], "t": []}], "preferred_name": "extratelencephalic-projecting glutamatergic cortical neuron", "taxa": []}
{"type": "biolink:Cell", "ic": 84.83823963392128, "identifiers": [{"i": "UMLS:C5856643", "l": "Anti-CD70 CAR T Cells Preparation", "d": [], "t": []}, {"i": "NCIT:C201176", "l": "Anti-CD70 CAR T Cells Preparation", "d": ["Any preparation of chimeric antigen receptor (CAR) expressing T-lymphocytes that targets the tumor-associated antigen (TAA) CD70."], "t": []}], "preferred_name": "Anti-CD70 CAR T Cells Preparation", "taxa": []}
{"type": "biolink:Cell", "ic": 80.96785908349635, "identifiers": [{"i": "CL:4023068", "l": "thalamic excitatory neuron", "d": ["An excitatory neuron that has its soma located in the thalamic complex. This neuron type can be involved in a series of circuits related to sensory integration, motor integration, pain processing, social behaviour and reward response."], "t": []}], "preferred_name": "thalamic excitatory neuron", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "UMLS:C4085194", "l": "Conventional Dendritic Cell", "d": [], "t": []}, {"i": "NCIT:C123782", "l": "Conventional Dendritic Cell", "d": ["A subset of dendritic cells that are derived from myeloid precursors. They express toll-like receptors 2 and 4 and secrete interleukin-12."], "t": []}], "preferred_name": "Conventional Dendritic Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 83.11065783093733, "identifiers": [{"i": "UMLS:C1515969", "l": "Anaplastic Plasma Cell", "d": [], "t": []}, {"i": "NCIT:C37081", "l": "Anaplastic Plasma Cell", "d": [], "t": []}], "preferred_name": "Anaplastic Plasma Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0019022", "l": "endothelial cell of pericentral hepatic sinusoid", "d": ["An endothelial cell found in the centrilobular region hepatic sinusoid, near the central vein. The fenestrae of these cells are smaller but more numerous compared with those of endothelial cells near the periportal region of the hepatic sinusoid."], "t": []}], "preferred_name": "endothelial cell of pericentral hepatic sinusoid", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C3827754", "l": "Tumor Infiltrating Macrophages", "d": [], "t": []}, {"i": "NCIT:C111027", "l": "Tumor Infiltrating Macrophages", "d": ["Non-neoplastic macrophages that infiltrate a tumor."], "t": []}], "preferred_name": "Tumor Infiltrating Macrophages", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C3534455", "l": "Anucleated bodies", "d": [], "t": []}], "preferred_name": "Anucleated bodies", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5163724", "l": "Erythrocytes | Semen | Fertility testing", "d": [], "t": []}], "preferred_name": "Erythrocytes | Semen | Fertility testing", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4033159", "l": "geniculate ganglion VGLUT2 neuron", "d": ["A sensory neuron that has the soma located in the geniculate ganglion and expresses the marker vesicular glutamate transporter 2 (VGLUT2)."], "t": []}], "preferred_name": "geniculate ganglion VGLUT2 neuron", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0000345", "l": "dental papilla cell", "d": ["A mesenchymal cell that is part of a small mass of condensed mesenchyme in the enamel organ; it differentiates into the dentin and dental pulp."], "t": []}], "preferred_name": "dental papilla cell", "taxa": []}
{"type": "biolink:Cell", "ic": 80.27409497666227, "identifiers": [{"i": "CL:0002352", "l": "gestational hematopoietic stem cell", "d": ["A hematopoietic stem cell that exists during embryogenesis."], "t": []}], "preferred_name": "gestational hematopoietic stem cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0020062", "l": "junctional epithelial cell", "d": ["An epithelial cell that is part of the junctional epithelium of the gingiva, forming a collar-like band around the cervix of the tooth. This cell attaches to the tooth surface via hemidesmosomes and an internal basal lamina rich in laminin-332 and ODAM (Gavriiloglou et al., 2024). The junctional epithelium is a stratified squamous non-keratinized epithelium ranging from 15-30 cell layers coronally to 1-3 cell layers apically. This cell expresses cytokeratin 19 (CK19) as a specific marker, along with ODAM and FDC-SP, and participates in innate immune defense by producing IL-8, IL-1alpha, and MMP-7, facilitating the transmigration of polymorphonuclear leukocytes through the epithelium (Gavriiloglou et al., 2024). This cell has a high turnover rate, with complete renewal occurring every 4-6 days (Lin et al., 2025), and develops from the reduced enamel epithelium during tooth eruption, although it can regenerate de novo without this precursor."], "t": []}], "preferred_name": "junctional epithelial cell", "taxa": []}
{"type": "biolink:Cell", "ic": 87.18682603146104, "identifiers": [{"i": "CL:0000904", "l": "central memory CD4-positive, alpha-beta T cell", "d": ["CD4-positive, alpha-beta memory T cell with the phenotype CCR7-positive, CD127-positive, CD45RA-negative, CD45RO-positive, and CD25-negative."], "t": []}], "preferred_name": "central memory CD4-positive, alpha-beta T cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C3178740", "l": "Be1 Cells", "d": [], "t": []}], "preferred_name": "Be1 Cells", "taxa": []}
{"type": "biolink:Cell", "ic": 59.09204608367191, "identifiers": [{"i": "UMLS:C1514022", "l": "Neoplastic Melanocyte", "d": [], "t": []}, {"i": "NCIT:C36862", "l": "Neoplastic Melanocyte", "d": [], "t": []}], "preferred_name": "Neoplastic Melanocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 73.04009684703995, "identifiers": [{"i": "UMLS:C0151776", "l": "Abnormal megakaryocyte", "d": [], "t": []}, {"i": "NCIT:C37043", "l": "Abnormal Megakaryocyte", "d": [], "t": []}, {"i": "SNOMEDCT:68425008", "l": "", "d": [], "t": []}], "preferred_name": "Abnormal megakaryocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 92.76600187037766, "identifiers": [{"i": "CL:0000931", "l": "activated type II NK T cell", "d": ["A type II NK T cell that has been recently activated, secretes interferon-gamma and interleukin-4, and has the phenotype CD69-positive and downregulated NK markers."], "t": []}], "preferred_name": "activated type II NK T cell", "taxa": []}
{"type": "biolink:Cell", "ic": 88.20185721311867, "identifiers": [{"i": "CL:2000044", "l": "brain microvascular endothelial cell", "d": ["Any microvascular endothelial cell that is part of a brain."], "t": []}], "preferred_name": "brain microvascular endothelial cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0883475", "l": "CD5+CD25+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:1373041005", "l": "", "d": [], "t": []}], "preferred_name": "CD5+CD25+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1183406", "l": "Epithelial cell of gut", "d": [], "t": []}], "preferred_name": "Epithelial cell of gut", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1517357", "l": "Geron H14 stem cell line", "d": [], "t": []}, {"i": "NCIT:C20260", "l": "GE14", "d": ["Provider: Geron Corporation, Menlo Park, CA. No information from provider. This cell line meets the criteria for the use of human embryonic stem cells by federally funded researchers."], "t": []}], "preferred_name": "Geron H14 stem cell line", "taxa": []}
{"type": "biolink:Cell", "ic": 80.96785908349635, "identifiers": [{"i": "UMLS:C5908901", "l": "Therapeutic Autologous Hematopoietic Stem Cells", "d": [], "t": []}, {"i": "NCIT:C203001", "l": "Therapeutic Autologous Hematopoietic Stem Cells", "d": ["Any preparation of autologous hematopoietic stem cells (HSCs)."], "t": []}], "preferred_name": "Therapeutic Autologous Hematopoietic Stem Cells", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4696004", "l": "CD3+CD8+CD27+CD62L+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:1373244005", "l": "", "d": [], "t": []}], "preferred_name": "CD3+CD8+CD27+CD62L+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5206827", "l": "Uzatresgene Autoleucel", "d": [], "t": []}, {"i": "NCIT:C162804", "l": "Uzatresgene Autoleucel", "d": ["Autologous human T-lymphocytes transduced with a retroviral vector encoding a T-cell receptor (TCR) specific for the human melanoma antigen A4 (MAGE-A4) and the CD8alpha co-receptor, with potential immunostimulatory and antineoplastic activities. Upon leukapheresis, isolation, transduction, expansion ex vivo, and reintroduction into the patient, uzatresgene autoleucel bind to tumor cells expressing MAGE-A4. This may result in both inhibition of growth and increased cell death of MAGE-A4-expressing tumor cells. The tumor-associated antigen MAGE-A4, a member of the MAGE-A family of cancer testis antigens, is overexpressed by a variety of cancer cell types. Co-expression of CD8alpha may broaden the immune response against tumors and increase antitumor activity by converting CD4+ helper T-cells into CD8+ cytotoxic T-cells."], "t": []}], "preferred_name": "Uzatresgene Autoleucel", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0596889", "l": "Mauthner's neuron", "d": [], "t": []}], "preferred_name": "Mauthner's neuron", "taxa": []}
{"type": "biolink:Cell", "ic": 77.17927671370501, "identifiers": [{"i": "CL:0000477", "l": "follicle cell of egg chamber", "d": ["A somatic epithelial cell of the insect egg chamber."], "t": []}], "preferred_name": "follicle cell of egg chamber", "taxa": []}
{"type": "biolink:Cell", "ic": 59.83141974270748, "identifiers": [{"i": "CL:0000148", "l": "melanocyte", "d": ["A pigment cell derived from the neural crest. Contains melanin-filled pigment granules, which gives a brown to black appearance."], "t": []}, {"i": "UMLS:C0025201", "l": "melanocyte", "d": [], "t": []}, {"i": "NCIT:C12591", "l": "Melanocyte", "d": [], "t": []}, {"i": "MESH:D008544", "l": "Melanocytes", "d": [], "t": []}, {"i": "SNOMEDCT:9683001", "l": "", "d": [], "t": []}], "preferred_name": "melanocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C2981182", "l": "Autologous EBV-CTL CD19CAR zeta", "d": [], "t": []}, {"i": "NCIT:C78824", "l": "Autologous EBV-CTL CD19CAR zeta", "d": ["Autologous Epstein-Barr virus (EBV)-specific cytotoxic T-lymphocytes (CTL) that have been genetically modified to express a T-cell chimeric antigen receptor (CAR) targeting the CD19 antigen, with potential immunotherapeutic activity. The CAR consists of a single chain Fv of anti-CD19 IgG1 coupled with an intracellular signaling region of the zeta-chain of the TCR/CD3 complex (CD3 zeta). Autologous EBV-CTL CD19CAR zeta directs the T-lymphocytes to CD19-expressing tumor cells, stimulating a selective toxicity to tumor cells. CD19 antigen is a B-cell specific cell surface antigen expressed in all B-cell lineage malignancies."], "t": []}], "preferred_name": "Autologous EBV-CTL CD19CAR zeta", "taxa": []}
{"type": "biolink:Cell", "ic": 87.18682603146104, "identifiers": [{"i": "CL:0002454", "l": "CD4-negative, CD8-alpha-negative, CD11b-positive dendritic cell", "d": ["CD4-negative, CD8-alpha-negative, CD11b-positive dendritic cell is a conventional dendritic cell that is CD11b-positive, CD4-negative, CD8-alpha-negative and is CD205-positive."], "t": []}], "preferred_name": "CD4-negative, CD8-alpha-negative, CD11b-positive dendritic cell", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "CL:0005002", "l": "xanthoblast", "d": ["A non-terminally differentiated cell that differentiates into a xanthophore."], "t": []}], "preferred_name": "xanthoblast", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5380995", "l": "Cells.CD8.HLA-B7 CMV specific.CMV antigen stimulated gamma interferon producing", "d": [], "t": []}], "preferred_name": "Cells.CD8.HLA-B7 CMV specific.CMV antigen stimulated gamma interferon producing", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:1000361", "l": "transitional myocyte of interatrial septum", "d": ["A transitional myocyte that is part of the interatrial septum."], "t": []}, {"i": "UMLS:C2336943", "l": "Transitional myocyte of interatrial septum", "d": [], "t": []}], "preferred_name": "transitional myocyte of interatrial septum", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5186011", "l": "Band form neutrophils | Fetus | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Band form neutrophils | Fetus | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1520103", "l": "WA01 cell line", "d": [], "t": []}, {"i": "NCIT:C20308", "l": "WA01", "d": ["Provider: Wisconsin Alumni Research Foundation (WARF), Madison, WI. Information from provider and not independently verified by NIH: Cells are positive for cell markers SSEA-3, SSEA-4, TRA-1-60, TRA-1-81, and alkaline phosphatase; Cells are negative for SSEA-1; Give rise to teratomas containing derivatives of three germ layers in SCID mice; Differentiate in vitro; Documented quality control includes karyotype analysis, DNA fingerprinting, mycoplasma testing, and human virus testing. Frozen vials of cells in passage 22 are available immediately. Publication: Thomson et al., Science 282, 1145, 1998. This cell line meets the criteria for the use of human embryonic stem cells by federally funded researchers."], "t": []}], "preferred_name": "WA01 cell line", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C4725789", "l": "Autologous BCMA/TACI-targeted CAR T Cells AUTO2", "d": [], "t": []}, {"i": "NCIT:C150509", "l": "Autologous BCMA/TACI-targeted CAR T Cells AUTO2", "d": ["A preparation of autologous T-lymphocytes that are genetically engineered to contain a dual-targeted chimeric antigen receptor (CAR), which includes the natural protein a proliferation-inducing ligand (APRIL; TNFSF13), that targets the tumor-associated antigens (TAAs) B-cell maturation antigen (BCMA; TNFRSF17) and transmembrane activator and calcium modulator and cyclophilin ligand interactor (TACI; TNFRSF13B), with potential immunomodulating and antineoplastic activities. Upon administration, the autologous BCMA/TACI-targeted CAR T-cells AUTO2 bind to BCMA and TACI expressed on tumor cells and induce selective cytotoxicity in those cells. In addition, AUTO2 carries the universal RQR8 safety \"off\" switch, which allows selective removal of the T-cells through both complement-dependent cytotoxicity (CDC) and antibody-dependent cellular cytotoxicity (ADCC) following administration of rituximab if unacceptable side-effects occur."], "t": []}], "preferred_name": "Autologous BCMA/TACI-targeted CAR T Cells AUTO2", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4505243", "l": "Suprachiasmatic Nucleus Neurons", "d": [], "t": []}, {"i": "MESH:D000074523", "l": "Suprachiasmatic Nucleus Neurons", "d": [], "t": []}], "preferred_name": "Suprachiasmatic Nucleus Neurons", "taxa": []}
{"type": "biolink:Cell", "ic": 57.67305536333419, "identifiers": [{"i": "CL:0002494", "l": "cardiocyte", "d": ["A cell located in the heart, including both muscle and non muscle cells."], "t": []}, {"i": "UMLS:C2333889", "l": "Cardiocyte - general anatomical term", "d": [], "t": []}], "preferred_name": "cardiocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0002106", "l": "IgD-positive CD38-positive IgG memory B cell", "d": ["An IgD-positive CD38-positive IgG memory B cell is a CD38-positive IgG-positive class switched memory B cell that has class switched and expresses IgD on the cell surface with the phenotype IgD-positive, CD38-positive, and IgG-positive."], "t": []}], "preferred_name": "IgD-positive CD38-positive IgG memory B cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0009029", "l": "mesothelial cell of appendix", "d": ["A mesothelial cell that is located in a vermiform appendix."], "t": []}], "preferred_name": "mesothelial cell of appendix", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1721028", "l": "Blastocyst Inner Cell Mass", "d": [], "t": []}, {"i": "MESH:D053624", "l": "Blastocyst Inner Cell Mass", "d": [], "t": []}], "preferred_name": "Blastocyst Inner Cell Mass", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5416843", "l": "CK0802", "d": [], "t": []}], "preferred_name": "CK0802", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1267958", "l": "Lymphocyte positive for CD66A antigen", "d": [], "t": []}, {"i": "SNOMEDCT:117399005", "l": "", "d": [], "t": []}], "preferred_name": "Lymphocyte positive for CD66A antigen", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5555588", "l": "CD8-depleted Non-engrafting HLA-mismatched Unrelated Donor Lymphocytes", "d": [], "t": []}, {"i": "NCIT:C179290", "l": "CD8-depleted Non-engrafting HLA-mismatched Unrelated Donor Lymphocytes", "d": ["A preparation of allogeneic lymphocytes from an HLA-mismatched donor that have been selectively depleted of CD8+ T-cells, with potential T-cell reconstitution purposes. Upon infusion, the donor-derived CD8+-depleted lymphocytes may increase the levels of CD4+ T-cells (Teffs) and promote T-cell reconstitution. The infusion of donor lymphocytes depleted of CD8 T-cells may reduce the risk of inducing graft-versus-host disease (GVHD) compared to the infusion of non-CD8-depleted T-cells."], "t": []}], "preferred_name": "CD8-depleted Non-engrafting HLA-mismatched Unrelated Donor Lymphocytes", "taxa": []}
{"type": "biolink:Cell", "ic": 92.76600187037766, "identifiers": [{"i": "CL:0003030", "l": "M3 retinal ganglion cell", "d": ["A monostratified retinal ganglion cell that has a medium soma and a small dendrite field."], "t": []}], "preferred_name": "M3 retinal ganglion cell", "taxa": []}
{"type": "biolink:Cell", "ic": 92.76600187037766, "identifiers": [{"i": "UMLS:C1514105", "l": "Neoplastic Subependymal Glial Cell", "d": [], "t": []}, {"i": "NCIT:C41451", "l": "Neoplastic Subependymal Glial Cell", "d": [], "t": []}], "preferred_name": "Neoplastic Subependymal Glial Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:3000002", "l": "sympathetic noradrenergic neuron", "d": ["Sympathetic noradrenergic neuron."], "t": []}], "preferred_name": "sympathetic noradrenergic neuron", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5854408", "l": "Allogeneic CRISPR-Cas9 Engineered Anti-CD19 CAR T-cells CTX112", "d": [], "t": []}, {"i": "NCIT:C199293", "l": "Allogeneic CRISPR-Cas9 Engineered Anti-CD19 CAR T-cells CTX112", "d": ["A preparation of human allogeneic T-lymphocytes transduced with a chimeric antigen receptor (CAR) specific for the tumor-associated antigen (TAA) CD19 and gene-edited with the clustered regularly interspaced short palindromic repeats (CRISPR)-Cas9 nuclease complex to eliminate endogenous TCR, transforming growth factor-beta receptor II (TGFbRII), and Regnase-1, with potential immunostimulating and antineoplastic activities. Upon introduction into the patient, the allogeneic CRISPR-Cas9 engineered anti-CD19 CAR T-cells CTX112 recognize and bind to CD19-expressing tumor cells. This may result in a specific cytotoxic T-lymphocyte (CTL)-mediated killing of CD19-positive tumor cells. Removal of endogenous TCR reduces the risk of graft-versus-host disease (GvHD). CD19 antigen is a B-cell specific cell surface antigen expressed in all B-cell lineage malignancies. Incorporation of the Regnase-1 and TGFBR2 double knockout increases the potency, persistence and efficacy of the CAR-T cells and enhances anti-tumor activity."], "t": []}], "preferred_name": "Allogeneic CRISPR-Cas9 Engineered Anti-CD19 CAR T-cells CTX112", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0009071", "l": "medullary thymic epithelial cell type 1", "d": ["A thymic medullary epithelial cell considered to be a pre-AIRE mTEC population."], "t": []}], "preferred_name": "medullary thymic epithelial cell type 1", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0020063", "l": "tuft cell of parotid gland", "d": ["A tuft cell that is part of the epithelium of the parotid gland, localized to the striated ducts and never observed in acini. This cell is characterized by expression of POU2F3 and is expected to possess chemosensory function consistent with tuft cells in other tissues. Immunohistochemical analysis of normal human parotid gland tissue detected POU2F3-positive cells as a very rare population within the ductal compartment, positioned on the luminal side (Hoki et al., 2024)."], "t": []}], "preferred_name": "tuft cell of parotid gland", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0545578", "l": "Marrow plasmablast", "d": [], "t": []}], "preferred_name": "Marrow plasmablast", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0002206", "l": "brush cell of terminal bronchiole", "d": ["A brush cell of the epithelium in the terminal bronchiole."], "t": []}, {"i": "UMLS:C2329360", "l": "Brush cell of epithelium of terminal bronchiole", "d": [], "t": []}], "preferred_name": "brush cell of terminal bronchiole", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5173060", "l": "Microcytes | Blood | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Microcytes | Blood | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4310145", "l": "AMY-SLEA-BNST D1 GABA GABAergic interneuron (Primate)", "d": ["A GABAergic interneuron of the Primates brain. These cells are located in the striatum . Reference transcriptomic data for this type can be found in the dataset/taxonomy - HMBA Basal Ganglia Consensus Taxonomy in cell set Group:AMY-SLEA-BNST D1 GABA."], "t": []}], "preferred_name": "AMY-SLEA-BNST D1 GABA GABAergic interneuron (Primate)", "taxa": []}
{"type": "biolink:Cell", "ic": 47.99157841056296, "identifiers": [{"i": "CL:0000842", "l": "mononuclear leukocyte", "d": ["A leukocyte with a single non-segmented nucleus in the mature form."], "t": []}, {"i": "UMLS:C1321301", "l": "Peripheral blood mononuclear cell (cell)", "d": [], "t": []}, {"i": "NCIT:C12954", "l": "Peripheral Blood Mononuclear Cell", "d": ["A peripheral blood cell with a single nucleus. This category includes lymphocytes and monocytes."], "t": []}, {"i": "SNOMEDCT:404798000", "l": "", "d": [], "t": []}], "preferred_name": "mononuclear leukocyte", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5177623", "l": "Platelets | Platelet rich plasma | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Platelets | Platelet rich plasma | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0002448", "l": "Ly49H-negative natural killer cell, mouse", "d": ["A NK1.1-positive T cell that is Ly49H-negative."], "t": []}], "preferred_name": "Ly49H-negative natural killer cell, mouse", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1267890", "l": "Lymphocyte positive for CD20 antigen", "d": [], "t": []}, {"i": "SNOMEDCT:116842001", "l": "", "d": [], "t": []}], "preferred_name": "Lymphocyte positive for CD20 antigen", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4030020", "l": "kidney connecting tubule alpha-intercalated cell", "d": ["A renal alpha-intercalated cell that is part of the renal connecting tubule."], "t": []}], "preferred_name": "kidney connecting tubule alpha-intercalated cell", "taxa": []}
{"type": "biolink:Cell", "ic": 87.18682603146104, "identifiers": [{"i": "CL:0000833", "l": "eosinophilic promyelocyte", "d": ["A promyelocyte committed to the eosinophil lineage."], "t": []}], "preferred_name": "eosinophilic promyelocyte", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1440232", "l": "CD10+CD19+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:1372955005", "l": "", "d": [], "t": []}], "preferred_name": "CD10+CD19+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": 73.26332733876373, "identifiers": [{"i": "UMLS:C1513756", "l": "Mummified Cell", "d": [], "t": []}, {"i": "NCIT:C37025", "l": "Mummified Cell", "d": [], "t": []}], "preferred_name": "Mummified Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1518218", "l": "Malignant Neuroendocrine Cell with Moderate Cytoplasm", "d": [], "t": []}, {"i": "NCIT:C36916", "l": "Malignant Neuroendocrine Cell with Moderate Cytoplasm", "d": [], "t": []}], "preferred_name": "Malignant Neuroendocrine Cell with Moderate Cytoplasm", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5908099", "l": "Nadravaleucel", "d": [], "t": []}], "preferred_name": "Nadravaleucel", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C2337416", "l": "Chromophilic cell", "d": [], "t": []}], "preferred_name": "Chromophilic cell", "taxa": []}
{"type": "biolink:Cell", "ic": 69.16971629661502, "identifiers": [{"i": "UMLS:C1514025", "l": "Neoplastic Mesothelial Cell", "d": [], "t": []}, {"i": "NCIT:C41605", "l": "Neoplastic Mesothelial Cell", "d": [], "t": []}], "preferred_name": "Neoplastic Mesothelial Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C4727553", "l": "Therapeutic Ex-vivo-treated Autologous Central Memory T Cells", "d": [], "t": []}, {"i": "NCIT:C154280", "l": "Therapeutic Ex-vivo-treated Autologous Central Memory T Cells", "d": ["A preparation of autologous ex-vivo treated central memory T (Tcm) cells with potential immunostimulatory activity. Upon isolation and ex-vivo treatment through as an of yet not elucidated method, the therapeutic ex-vivo-treated autologous Tcm cells, upon reintroduction into the patient, can activate an antitumor immune response which may eradicate tumor cells."], "t": []}], "preferred_name": "Therapeutic Ex-vivo-treated Autologous Central Memory T Cells", "taxa": []}
{"type": "biolink:Cell", "ic": 88.20185721311867, "identifiers": [{"i": "UMLS:C1709207", "l": "Neoplastic Striated Muscle Cell with Eosinophilic Granular Cytoplasm", "d": [], "t": []}, {"i": "NCIT:C49170", "l": "Neoplastic Striated Muscle Cell with Eosinophilic Granular Cytoplasm", "d": [], "t": []}], "preferred_name": "Neoplastic Striated Muscle Cell with Eosinophilic Granular Cytoplasm", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C6005370", "l": "Amimestrocel", "d": [], "t": []}], "preferred_name": "Amimestrocel", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0000984", "l": "IgA plasmablast", "d": ["A plasmablast that secretes IgA."], "t": []}], "preferred_name": "IgA plasmablast", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1257743", "l": "3T3-L1 Cells", "d": [], "t": []}, {"i": "MESH:D041721", "l": "3T3-L1 Cells", "d": [], "t": []}], "preferred_name": "3T3-L1 Cells", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5886352", "l": "Amniocytes", "d": [], "t": []}], "preferred_name": "Amniocytes", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5854578", "l": "Allogeneic Anti-CD7 CAR-T Cells BEAM-201", "d": [], "t": []}, {"i": "NCIT:C200791", "l": "Allogeneic Anti-CD7 CAR-T Cells BEAM-201", "d": ["A preparation of off-the-shelf (OTS) donor-derived T-lymphocytes that have been multiplex base-edited and transduced with a lentiviral vector to express a chimeric antigen receptor (CAR) directed against the tumor-associated antigen (TAA) CD7, with potential immunostimulating and antineoplastic activities. Upon administration, allogeneic anti-CD7 CAR-T cells BEAM-201 specifically target and kill CD7-expressing tumor cells. CD7 is a transmembrane glycoprotein expressed by T-cells and natural killer (NK) cells and their precursors. It is expressed in the majority of lymphoblastic T-cell leukemias and lymphomas and in a subset of peripheral T-cell lymphomas."], "t": []}], "preferred_name": "Allogeneic Anti-CD7 CAR-T Cells BEAM-201", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0000470", "l": "digestive enzyme secreting cell", "d": [], "t": []}], "preferred_name": "digestive enzyme secreting cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5420597", "l": "Mixed Adherent Cells in Suspension", "d": [], "t": []}, {"i": "NCIT:C174118", "l": "Mixed Adherent Cells in Suspension", "d": ["A sample comprised of a mixture of cells or clumps of cells, which may have been isolated from normal or tumor tissues, that are maintained in a suspension culture."], "t": []}], "preferred_name": "Mixed Adherent Cells in Suspension", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4033122", "l": "lumbar ganglion SST/TH neuron", "d": ["A sympathetic neuron that has the soma located in the lumbar ganglion and expresses the marker somatostatin (SST) and tyrosine hydroxylase (TH)."], "t": []}], "preferred_name": "lumbar ganglion SST/TH neuron", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5157342", "l": "CD19 blasts | Blood | Cell markers", "d": [], "t": []}], "preferred_name": "CD19 blasts | Blood | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C2709115", "l": "CD138+lambda+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:1376044005", "l": "", "d": [], "t": []}], "preferred_name": "CD138+lambda+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1267879", "l": "Lymphocyte positive for CD16B antigen", "d": [], "t": []}, {"i": "SNOMEDCT:117556001", "l": "", "d": [], "t": []}], "preferred_name": "Lymphocyte positive for CD16B antigen", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4301985", "l": "Motile spermatozoa", "d": [], "t": []}, {"i": "SNOMEDCT:723202000", "l": "", "d": [], "t": []}], "preferred_name": "Motile spermatozoa", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C2362002", "l": "CD41-Bf", "d": [], "t": []}], "preferred_name": "CD41-Bf", "taxa": []}
{"type": "biolink:Cell", "ic": 78.05853671694304, "identifiers": [{"i": "UMLS:C1515962", "l": "Anaplastic Astrocyte", "d": [], "t": []}, {"i": "NCIT:C37136", "l": "Anaplastic Astrocyte", "d": [], "t": []}], "preferred_name": "Anaplastic Astrocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4310128", "l": "STRd cholinergic-GABAergic neuron (Primate)", "d": ["A dorso-striatal cholinergic-GABAergic neuron of the Primates brain. These cells are located in the striatum . Reference transcriptomic data for this type can be found in the dataset/taxonomy - HMBA Basal Ganglia Consensus Taxonomy in cell set Group:STRd Cholinergic GABA."], "t": []}], "preferred_name": "STRd cholinergic-GABAergic neuron (Primate)", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C4744926", "l": "Bone Marrow Mononuclear Cell", "d": [], "t": []}, {"i": "NCIT:C156591", "l": "Bone Marrow Mononuclear Cell", "d": ["Any cell with a single nucleus found in the bone marrow, for example lymphocytes, monocytes, mesenchymal stem cells and hematopoietic progenitor cells."], "t": []}], "preferred_name": "Bone Marrow Mononuclear Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 82.16838616155795, "identifiers": [{"i": "UMLS:C1519111", "l": "Round Cell with Primitive Myoblastic Differentiation", "d": [], "t": []}, {"i": "NCIT:C36951", "l": "Round Cell with Primitive Myoblastic Differentiation", "d": [], "t": []}], "preferred_name": "Round Cell with Primitive Myoblastic Differentiation", "taxa": []}
{"type": "biolink:Cell", "ic": 92.76600187037766, "identifiers": [{"i": "CL:0000711", "l": "cumulus granulosa cell", "d": ["Cumulus cell is a specialized granulosa cell that surrounds and nourishes the oocyte. This cell-type surrounds the fully-grown oocyte to form a cumulus-oocyte complex (abbr. COC). The terms cumulus oophorus cells, cumulus granulosa cells, cumulus oophorous granulosa cells, granulosa-cumulus cells are used to make a distinction between this cell and the other functionally different subpopulation of granulosa cells at the wall of the Graafian follicle."], "t": []}, {"i": "UMLS:C1956101", "l": "Cumulus Cells", "d": [], "t": []}, {"i": "MESH:D054885", "l": "Cumulus Cells", "d": [], "t": []}], "preferred_name": "cumulus granulosa cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1267935", "l": "Lymphocyte positive for CD48 antigen", "d": [], "t": []}, {"i": "SNOMEDCT:117378007", "l": "", "d": [], "t": []}], "preferred_name": "Lymphocyte positive for CD48 antigen", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4322815", "l": "CD45RO+ T lymphocyte", "d": [], "t": []}], "preferred_name": "CD45RO+ T lymphocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "CL:0002301", "l": "type B synovial cell", "d": ["A resident stromal cell located in the synovial membrane and responsible for the production of immune-related cytokines and chemokines. This cell type secretes glycoproteins and hyaluronic acid, has abundant granular endoplasmic reticulum, but contains fewer vacuoles and vesicles."], "t": []}, {"i": "UMLS:C0933804", "l": "Type B synoviocyte", "d": [], "t": []}], "preferred_name": "type B synovial cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5572250", "l": "Epithelial cells | Bronchoalveolar lavage | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Epithelial cells | Bronchoalveolar lavage | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": 88.20185721311867, "identifiers": [{"i": "CL:4033084", "l": "cuboidal granulosa cell", "d": ["A granulosa cell that has a cuboidal morphology and develops from squamous granulosa cell during the transition between primordial follicle to primary follicle. Cuboidal granulosa cells proliferate to form a second layer within secondary follicles."], "t": []}], "preferred_name": "cuboidal granulosa cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4310100", "l": "GPe-NDB-SI LHX6-LHX8-GBX1 GABA GABAergic interneuron (Primate)", "d": ["A GABAergic interneuron of the Primates brain. These cells are located in the striatum, external segment of globus pallidus . Reference transcriptomic data for this type can be found in the dataset/taxonomy - HMBA Basal Ganglia Consensus Taxonomy in cell set Group:GPe-NDB-SI LHX6-LHX8-GBX1 GABA."], "t": []}], "preferred_name": "GPe-NDB-SI LHX6-LHX8-GBX1 GABA GABAergic interneuron (Primate)", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1513815", "l": "NC02", "d": [], "t": []}, {"i": "NCIT:C20282", "l": "NC02", "d": ["Provider: National Centre for Biological Sciences/ Tata Institute of Fundamental Research, Bangalore, India. No information from provider. This cell line meets the criteria for the use of human embryonic stem cells by federally funded researchers."], "t": []}], "preferred_name": "NC02", "taxa": []}
{"type": "biolink:Cell", "ic": 77.60424150429895, "identifiers": [{"i": "CL:1000600", "l": "lower urinary tract cell", "d": ["Any cell that is part of some lower urinary tract."], "t": []}], "preferred_name": "lower urinary tract cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0002297", "l": "type-3 epithelial cell of thymus", "d": ["A thymic epithelial cell with moderate nuclear and cytoplasmic electron-density. Scattered in the cortex, this cell type is predominant in the mid and deep cortex."], "t": []}, {"i": "UMLS:C1183359", "l": "Type-3 epithelial cell of thymus", "d": [], "t": []}], "preferred_name": "type-3 epithelial cell of thymus", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5382907", "l": "HLA-B7 CMV specific CD8 cells | Blood | Cell markers", "d": [], "t": []}], "preferred_name": "HLA-B7 CMV specific CD8 cells | Blood | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0229615", "l": "Pyroninophilic lymphoid cell", "d": [], "t": []}, {"i": "SNOMEDCT:20472006", "l": "", "d": [], "t": []}], "preferred_name": "Pyroninophilic lymphoid cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5417845", "l": "Autologous Clonal Neoantigen T Cells ATL001", "d": [], "t": []}, {"i": "NCIT:C171097", "l": "Autologous Clonal Neoantigen T Cells ATL001", "d": ["A preparation of personalized tumor-derived T-lymphocytes composed of tumor infiltrating lymphocytes (TILs) that are reactive to clonal cancer neoantigens, with potential immunostimulating and antineoplastic activities. The TILs are removed from the suppressive tumor microenvironment (TME) and re-activated. Upon reintroduction into the patient, the clonal neoantigen T (cNeT) cells recognize and bind to tumor cells expressing the targeted neoantigen, resulting in a cytotoxic T-lymphocyte (CTL)-mediated immune response against the patient's tumor cells."], "t": []}], "preferred_name": "Autologous Clonal Neoantigen T Cells ATL001", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "UMLS:C1317543", "l": "Immature monocytes", "d": [], "t": []}, {"i": "NCIT:C13120", "l": "Immature Monocyte", "d": ["A cell derived from a myeloid stem cell. It is the representation of one stage of monocyte development."], "t": []}, {"i": "SNOMEDCT:655151010000103", "l": "", "d": [], "t": []}], "preferred_name": "Immature monocytes", "taxa": []}
{"type": "biolink:Cell", "ic": 92.76600187037766, "identifiers": [{"i": "CL:4023169", "l": "trigeminal neuron", "d": ["A neuron that is responsible for sensation in the face or motor functions such as biting and chewing. Trigeminal neurons extend a single axon shaft along the lateral white matter of the hindbrain and spinal cord. The highly branched axons innervate the integument of the head."], "t": []}], "preferred_name": "trigeminal neuron", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1267902", "l": "Lymphocyte positive for CD29 antigen", "d": [], "t": []}, {"i": "SNOMEDCT:117573004", "l": "", "d": [], "t": []}], "preferred_name": "Lymphocyte positive for CD29 antigen", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5909986", "l": "Allogeneic CD33CAR-CD3zeta-4-1BB-expressing T-lymphocytes", "d": [], "t": []}, {"i": "NCIT:C204783", "l": "Allogeneic CD33CAR-CD3zeta-4-1BB-expressing T-lymphocytes", "d": ["A preparation of allogeneic T-lymphocytes transduced with a lentiviral vector expressing a chimeric antigen receptor (CAR) specific for the CD33 antigen, coupled to the signaling domain of 4-1BB (CD137) and the zeta chain of the T-cell receptor (TCRzeta), with potential immunomodulating and antineoplastic activities. Upon administration, allogeneic CD33CAR-CD3zeta-4-1BB-expressing T-lymphocytes target and induce selective toxicity in CD33-expressing tumor cells. CD33 is expressed on normal non-pluripotent hematopoietic stem cells and on myeloid leukemia cells."], "t": []}], "preferred_name": "Allogeneic CD33CAR-CD3zeta-4-1BB-expressing T-lymphocytes", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5783961", "l": "Cell Membrane-anchored/CSV-targeted IL-12-expressing T-lymphocytes", "d": [], "t": []}, {"i": "NCIT:C190860", "l": "Cell Membrane-anchored/CSV-targeted IL-12-expressing T-lymphocytes", "d": ["A preparation of T-lymphocytes engineered to express cell membrane-anchored and cell-surface vimentin (CSV)-targeted interleukin-12 (IL-12), with potential immunostimulatory and antineoplastic activities. Upon administration, the cell membrane-anchored/CSV-targeted IL-12-expressing T-lymphocytes are directed to and induce selective toxicity in CSV-expressing tumor cells. The cell membrane-anchored IL-12 cytokine promotes the secretion of interferon-gamma (IFNg), activates natural killer cells (NKs), and induces cytotoxic T-lymphocyte (CTL) responses against tumor cells locally, which may result in immune-mediated tumor cell death and the inhibition of tumor cell proliferation. Vimentin, overexpressed in various tumors, is associated with tumor growth and metastasis. Cell membrane-anchored IL-12 reduces the circulating levels of the inflammatory cytokine and the associated systemic adverse effects."], "t": []}], "preferred_name": "Cell Membrane-anchored/CSV-targeted IL-12-expressing T-lymphocytes", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5186736", "l": "Leukocytes other | Fetus | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Leukocytes other | Fetus | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5182777", "l": "TCR gamma delta cells | Blood | Cell markers", "d": [], "t": []}], "preferred_name": "TCR gamma delta cells | Blood | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": 88.20185721311867, "identifiers": [{"i": "UMLS:C5909956", "l": "Melanocyte with Clear Cytoplasm", "d": [], "t": []}, {"i": "NCIT:C204744", "l": "Melanocyte with Clear Cytoplasm", "d": ["A neoplastic large melanocyte with abundant clear cytoplasm."], "t": []}], "preferred_name": "Melanocyte with Clear Cytoplasm", "taxa": []}
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{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0521392", "l": "Peripheral motor neuron", "d": [], "t": []}], "preferred_name": "Peripheral motor neuron", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1518789", "l": "PG13/LNc8 Retroviral Transduced Cloned T-Cells", "d": [], "t": []}, {"i": "NCIT:C2790", "l": "PG13/LNc8 Retroviral Transduced Cloned T-Cells", "d": ["A preparation of T lymphocytes harvested from a patient with cancer and transduced with the PG13/Lnc8 retroviral vector, a clone of the LN vector that encodes the neomycin phosphotransferase gene.  The modified T lymphocytes are cloned using an ex vivo technique and infused back into the patient, where they may elicit a host immune response against tumor cells.  The neomycin phosphotransferase gene product has no direct therapeutic value; it serves as a molecular marker to monitor the presence and localization of the PG13/Lnc8-transduced T-lymphocytes in the host. (NCI04)"], "t": []}], "preferred_name": "PG13/LNc8 Retroviral Transduced Cloned T-Cells", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5706465", "l": "Autologous Anti-CD7 CAR T-cells SENL101", "d": [], "t": []}, {"i": "NCIT:C188233", "l": "Autologous Anti-CD7 CAR T-cells SENL101", "d": ["A preparation of autologous T-lymphocytes that have been genetically engineered to express a chimeric antigen receptor (CAR) directed against the tumor-associated antigen (TAA) CD7, with potential immunostimulating and antineoplastic activities. Upon intravenous administration, the autologous anti-CD7 CAR T-cells SENL101 specifically recognize and bind to CD7-expressing tumor cells, resulting in specific T-cell-mediated tumor cell lysis. CD7 is a transmembrane glycoprotein expressed by T-cells and natural killer (NK) cells and their precursors. It is expressed in the majority of lymphoblastic T-cell leukemias and lymphomas and in a subset of peripheral T-cell lymphomas."], "t": []}], "preferred_name": "Autologous Anti-CD7 CAR T-cells SENL101", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1267864", "l": "Lymphocyte positive for CD11 antigen", "d": [], "t": []}, {"i": "SNOMEDCT:117545001", "l": "", "d": [], "t": []}], "preferred_name": "Lymphocyte positive for CD11 antigen", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4030030", "l": "peripheral blood lymphocyte", "d": ["A blood lymphocyte located in the flowing, circulating blood of the body."], "t": []}], "preferred_name": "peripheral blood lymphocyte", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5157495", "l": "CD34 cells | Body fluid | Cell markers", "d": [], "t": []}], "preferred_name": "CD34 cells | Body fluid | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": 83.63771255585968, "identifiers": [{"i": "CL:4042013", "l": "Lamp5 Lhx6 neuron", "d": ["A transcriptomically distinct GABAergic interneuron marked by Lamp5 and Lhx6 expression, derived from the Medial Ganglionic Eminence (MGE), and located in the pallium.", "A transcriptomically distinct lamp5 GABAergic cortical interneuron located in the cerebral cortex that expresses Lamp5 and Lhx6. The standard transcriptomic reference data for this cell type can be found on the CellxGene census under the collection: 'Transcriptomic cytoarchitecture reveals principles of human neocortex organization', dataset: 'Supercluster: CGE-derived interneurons', Author Categories: 'CrossArea_subclass', Lamp5 Lhx6."], "t": []}], "preferred_name": "Lamp5 Lhx6 neuron", "taxa": []}
{"type": "biolink:Cell", "ic": 61.48413325233415, "identifiers": [{"i": "CL:0000110", "l": "peptidergic neuron", "d": ["A neuron that uses neuropeptides as transmitters."], "t": []}], "preferred_name": "peptidergic neuron", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C4724740", "l": "CMV/EBV/ADV/BKV-specific Cytotoxic T Lymphocytes", "d": [], "t": []}, {"i": "NCIT:C150381", "l": "CMV/EBV/ADV/BKV-specific Cytotoxic T Lymphocytes", "d": ["A population of cytotoxic T-lymphocytes (CTLs) specifically reactive to cytomegalovirus (CMV), Epstein-Barr virus (EBV), adenovirus (ADV) and BK virus (BKV), with potential antiviral and protective activities. T-cells derived from peripheral blood mononuclear cells (PBMCs) are exposed to and activated by dendritic cells (DCs) that are loaded with specific peptides from CMV, EBV, ADV and BKV. Upon infusion of the CMV/EBV/ADV/BKV-specific CTLs, these lymphocytes target and cause lysis of CMV-, EBV-, ADV- and/or BKV-infected cells and may prevent infection and complications from CMV-, EBV-, ADV- and BKV-driven viral diseases. Opportunistic infections caused by these viruses are often seen in immunosuppressed patients."], "t": []}], "preferred_name": "CMV/EBV/ADV/BKV-specific Cytotoxic T Lymphocytes", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0427536", "l": "white blood cell type", "d": [], "t": []}], "preferred_name": "white blood cell type", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0002288", "l": "type V taste receptor cell", "d": ["A cell type that forms the boundary with the surrounding epithelium."], "t": []}, {"i": "UMLS:C1180369", "l": "Type V taste bud cell", "d": [], "t": []}], "preferred_name": "type V taste receptor cell", "taxa": []}
{"type": "biolink:Cell", "ic": 92.76600187037766, "identifiers": [{"i": "CL:0008037", "l": "gamma motor neuron", "d": ["A lower motor neuron that innervates only intrafusal muscle fibers. Unlike the alpha motor neurons, gamma motor neurons do not directly adjust the lengthening or shortening of muscles but function in adjusting the sensitivity of muscle spindles and in keeping muscle spindles taut, thereby allowing the continued firing of alpha neurons."], "t": []}, {"i": "UMLS:C0026610", "l": "Motor Neurons, Gamma", "d": [], "t": []}, {"i": "NCIT:C12646", "l": "Gamma Motor Neuron", "d": ["A type of motor neuron, found in the ventral horn of the spinal cord, that innervates intrafusal muscle fibers of neuromuscular spindles to help regulate skeletal muscle tone."], "t": []}, {"i": "MESH:D009047", "l": "Motor Neurons, Gamma", "d": [], "t": []}], "preferred_name": "gamma motor neuron", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "CL:2000038", "l": "posterior lateral line neuromast mantle cell", "d": ["Any neuromast mantle cell that is part of a posterior lateral line."], "t": []}], "preferred_name": "posterior lateral line neuromast mantle cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5669562", "l": "Azamidugene Autotemcel", "d": [], "t": []}, {"i": "NCIT:C184823", "l": "Azamidugene Autotemcel", "d": [], "t": []}], "preferred_name": "Azamidugene Autotemcel", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C2953590", "l": "Type D enteroendocrine cell of epithelium proper of duodenum", "d": [], "t": []}], "preferred_name": "Type D enteroendocrine cell of epithelium proper of duodenum", "taxa": []}
{"type": "biolink:Cell", "ic": 81.743421370964, "identifiers": [{"i": "CL:0002028", "l": "basophil mast progenitor cell", "d": ["A cell type that can give rise to basophil and mast cells. This cell is CD34-positive, CD117-positive, CD125-positive, FceRIa-negative, and T1/ST2-negative, and expresses Gata-1, Gata-2, C/EBPa"], "t": []}], "preferred_name": "basophil mast progenitor cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5886263", "l": "Cells.CD3+HLA DR+", "d": [], "t": []}], "preferred_name": "Cells.CD3+HLA DR+", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5417851", "l": "Autologous Anti-B7-H3/CD19 CAR T-cells SCRI-CARB7H3(s)x19", "d": [], "t": []}, {"i": "NCIT:C171318", "l": "Autologous Anti-B7-H3/CD19 CAR T-cells SCRI-CARB7H3(s)x19", "d": ["A preparation of autologous CD4+ and CD8+ T-lymphocytes lentivirally transduced to express a chimeric antigen receptor (CAR) targeting the immunoregulatory protein B7-homologue 3 (B7-H3, CD276) and the tumor-associated antigen (TAA) CD19, and containing, as of yet undisclosed co-stimulatory signaling domains, and a truncated form of the human epidermal growth factor receptor (EGFRt), with potential immunostimulating and antineoplastic activities. Upon administration, anti-B7-H3/CD19 CAR T-cells target and bind to both B7-H3 on T-cells and CD19 on tumor cells. This crosslinks T-cells and tumor cells, and induces selective toxicity in B7-H3/CD19-expressing tumor cells. B7-H3, a type I transmembrane protein and a member of the B7 co-stimulatory protein superfamily, is overexpressed on certain tumor cell types and on various immune cells. It promotes the activation of T cells. CD19, a transmembrane phosphoglycoprotein expressed on the surface of cells in the B lineage, are often overexpressed on malignant B-cells. Devoid of both ligand binding domains and tyrosine kinase activity, the expressed EGFRt both facilitates in vivo detection of the administered, transduced T-cells and can promote elimination of those cells through a cetuximab-induced antibody dependent cellular cytotoxicity (ADCC) response."], "t": []}], "preferred_name": "Autologous Anti-B7-H3/CD19 CAR T-cells SCRI-CARB7H3(s)x19", "taxa": []}
{"type": "biolink:Cell", "ic": 75.70995031940328, "identifiers": [{"i": "CL:0000909", "l": "CD8-positive, alpha-beta memory T cell", "d": ["A CD8-positive, alpha-beta T cell that has differentiated into a memory T cell."], "t": []}], "preferred_name": "CD8-positive, alpha-beta memory T cell", "taxa": []}
{"type": "biolink:Cell", "ic": 55.59260346615606, "identifiers": [{"i": "CL:0000945", "l": "lymphocyte of B lineage", "d": ["A lymphocyte of B lineage with the commitment to express an immunoglobulin complex."], "t": []}], "preferred_name": "lymphocyte of B lineage", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4304491", "l": "Population of all polymorphonuclear cells in portion of fluid", "d": [], "t": []}, {"i": "SNOMEDCT:719697003", "l": "", "d": [], "t": []}], "preferred_name": "Population of all polymorphonuclear cells in portion of fluid", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C6004919", "l": "Zevaskyn", "d": [], "t": []}], "preferred_name": "Zevaskyn", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4310130", "l": "striosomal D1 medium spiny neuron (Primate)", "d": ["A striosomal D1 medium spiny neuron of the Primates brain. These cells are located in the striatum . Reference transcriptomic data for this type can be found in the dataset/taxonomy - HMBA Basal Ganglia Consensus Taxonomy in cell set Group:STRd D1 Striosome MSN."], "t": []}], "preferred_name": "striosomal D1 medium spiny neuron (Primate)", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:1000473", "l": "myoepithelial cell of quarternary lactiferous duct", "d": ["A myoepithelial cell that is part of the quarternary lactiferous duct."], "t": []}, {"i": "UMLS:C1184141", "l": "Myoepithelial cell of quarternary lactiferous duct", "d": [], "t": []}], "preferred_name": "myoepithelial cell of quarternary lactiferous duct", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5216289", "l": "Neutrophils.segmented|NCnc|Pt|Body fld", "d": [], "t": []}], "preferred_name": "Neutrophils.segmented|NCnc|Pt|Body fld", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5157334", "l": "CD16-CD57- | White blood cells | Cell markers", "d": [], "t": []}], "preferred_name": "CD16-CD57- | White blood cells | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1441340", "l": "100 cells", "d": [], "t": []}], "preferred_name": "100 cells", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1513976", "l": "Neoplastic Glandular Cell with Enlarged Nucleus and Prominent Nucleolus", "d": [], "t": []}, {"i": "NCIT:C37128", "l": "Neoplastic Glandular Cell with Enlarged Nucleus and Prominent Nucleolus", "d": [], "t": []}], "preferred_name": "Neoplastic Glandular Cell with Enlarged Nucleus and Prominent Nucleolus", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5216302", "l": "Nucleated cells|NCnc|Pt|Periton fld", "d": [], "t": []}], "preferred_name": "Nucleated cells|NCnc|Pt|Periton fld", "taxa": []}
{"type": "biolink:Cell", "ic": 88.20185721311867, "identifiers": [{"i": "CL:4023130", "l": "kisspeptin neuron", "d": ["A neuron that expresses kisspeptin. These neurons are predominantly located in the hypothalamus, but also found in other parts of the brain including the hippocampal dentate gyrus."], "t": []}], "preferred_name": "kisspeptin neuron", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0002679", "l": "natural helper lymphocyte", "d": ["A lymphocyte found in adipose tissue that lacks lineage markers of other lymphocytes but is capable of mediating TH2 cytokine responses. This cell type is found in fat associated lymphoid clusters, proliferates in response to IL2 and produce large amounts of TH2 cytokines such as IL5, IL6 and IL13"], "t": []}], "preferred_name": "natural helper lymphocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 75.70995031940328, "identifiers": [{"i": "CL:2000008", "l": "microvascular endothelial cell", "d": ["Any blood vessel endothelial cell that is part of a microvascular endothelium."], "t": []}], "preferred_name": "microvascular endothelial cell", "taxa": []}
{"type": "biolink:Cell", "ic": 86.30756602822301, "identifiers": [{"i": "UMLS:C1883046", "l": "Small Cuboidal Cell Resembling Fetal Hepatocyte", "d": [], "t": []}, {"i": "NCIT:C60804", "l": "Small Cuboidal Cell Resembling Fetal Hepatocyte", "d": [], "t": []}], "preferred_name": "Small Cuboidal Cell Resembling Fetal Hepatocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 52.78207391601376, "identifiers": [{"i": "CL:0000084", "l": "T cell", "d": ["A type of lymphocyte whose defining characteristic is the expression of a T cell receptor complex."], "t": []}, {"i": "UMLS:C0039194", "l": "T-Lymphocyte", "d": [], "t": []}, {"i": "NCIT:C12476", "l": "T-Lymphocyte", "d": ["A thymocyte-derived lymphocyte of immunological importance that is long-lived (months to years) and is responsible for cell-mediated immunity. T lymphocyte cells form rosettes with sheep erythrocytes and, in the presence of transforming agents (mitogens), differentiate and divide. These cells have the characteristic T3 surface marker and may be further divided into subsets according to function, such as helper, cytotoxic, etc."], "t": []}, {"i": "MESH:D013601", "l": "T-Lymphocytes", "d": [], "t": []}, {"i": "SNOMEDCT:57184004", "l": "", "d": [], "t": []}], "preferred_name": "T cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0229662", "l": "Marrow fibrocyte", "d": [], "t": []}, {"i": "SNOMEDCT:42901005", "l": "", "d": [], "t": []}], "preferred_name": "Marrow fibrocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0008015", "l": "inhibitory motor neuron", "d": ["A motor neuron that is capable of directly inhibiting muscle contraction."], "t": []}], "preferred_name": "inhibitory motor neuron", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0000343", "l": "visual pigment cell (sensu Vertebrata)", "d": ["A pigment cell that is capable of detecting light stimulus that is involved in visual perception."], "t": []}, {"i": "UMLS:C0440745", "l": "Pigment cell", "d": [], "t": []}, {"i": "SNOMEDCT:256892003", "l": "", "d": [], "t": []}], "preferred_name": "visual pigment cell (sensu Vertebrata)", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5157237", "l": "CD10 cells | Blood | Cell markers", "d": [], "t": []}], "preferred_name": "CD10 cells | Blood | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "MESH:D065309", "l": "Atypical Squamous Cells of the Cervix", "d": [], "t": []}], "preferred_name": "Atypical Squamous Cells of the Cervix", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5395460", "l": "Autologous cultured chondrocyte-containing product", "d": [], "t": []}, {"i": "SNOMEDCT:840611003", "l": "", "d": [], "t": []}], "preferred_name": "Autologous cultured chondrocyte-containing product", "taxa": []}
{"type": "biolink:Cell", "ic": 59.430489990794015, "identifiers": [{"i": "UMLS:C1517808", "l": "Leukemic Lymphocyte", "d": [], "t": []}, {"i": "NCIT:C41073", "l": "Leukemic Lymphocyte", "d": [], "t": []}], "preferred_name": "Leukemic Lymphocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5983815", "l": "Allogeneic Anti-CD20 CAR T Cells LUCAR-20SP", "d": [], "t": []}, {"i": "NCIT:C212067", "l": "Allogeneic Anti-CD20 CAR T Cells LUCAR-20SP", "d": ["A preparation of donor-derived T-lymphocytes that have been genetically modified to express a chimeric antigen receptor (CAR) targeting the tumor-associated antigen (TAA) cluster of differentiation 20 (CD20), with potential immunostimulating and antineoplastic activities. Upon administration, allogeneic anti-CD20 CAR T-cells LUCAR-20SP specifically recognize and kill CD20-expressing tumor cells. CD20, a non-glycosylated cell surface phosphoprotein, is a B-cell specific cell surface antigen expressed in B-cell lineage malignancies."], "t": []}], "preferred_name": "Allogeneic Anti-CD20 CAR T Cells LUCAR-20SP", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C4733660", "l": "Total Tumor mRNA-pulsed Tumor-specific Ex vivo-expanded Autologous Lymphocyte Transfer Cells", "d": [], "t": []}, {"i": "NCIT:C155969", "l": "Total Tumor mRNA-pulsed Tumor-specific Ex vivo-expanded Autologous Lymphocyte Transfer Cells", "d": ["A preparation of ex vivo expanded, autologous lymphocyte transfer cells (xALTs) that are loaded with total tumor RNA (TTRNA) derived from autologous tumor cells, with potential immunostimulatory and antineoplastic activities. Upon re-infusion of the TTRNA-loaded ALTs into the patient, these ALTs may elicit a highly specific cytotoxic T-lymphocyte (CTL) response against the tumor-associated antigens (TAAs) encoded by the TTRNA."], "t": []}], "preferred_name": "Total Tumor mRNA-pulsed Tumor-specific Ex vivo-expanded Autologous Lymphocyte Transfer Cells", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C3714800", "l": "SCID-Repopulating Cell", "d": [], "t": []}, {"i": "NCIT:C114279", "l": "SCID-Repopulating Cell", "d": ["A human hematopoietic stem cell that is able to repopulate the hematopoietic system of non-obese diabetic/severe combined immunodeficient mice (NOD/SCID). Ex vivo culture conditions that can enrich these stem cells from peripheral blood samples could potentially be used to treat immunodeficiency in human patients."], "t": []}], "preferred_name": "SCID-Repopulating Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 89.40238429118027, "identifiers": [{"i": "UMLS:C1708709", "l": "Lipoblast-Like Malignant Transitional Cell", "d": [], "t": []}, {"i": "NCIT:C54562", "l": "Lipoblast-Like Malignant Transitional Cell", "d": [], "t": []}], "preferred_name": "Lipoblast-Like Malignant Transitional Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 89.40238429118027, "identifiers": [{"i": "CL:0001074", "l": "CD34-positive, CD56-positive, CD117-positive common innate lymphoid precursor, human", "d": ["An innate lymphoid cell precursor in the human with the phenotype CD34-positive, CD56-positive, CD117-positive.Thie cell type may include precusors to NK cells and ILC3 cells."], "t": []}], "preferred_name": "CD34-positive, CD56-positive, CD117-positive common innate lymphoid precursor, human", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "CL:0000348", "l": "choroidal cell of the eye", "d": ["A cell that is part of optic choroid."], "t": []}], "preferred_name": "choroidal cell of the eye", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5186791", "l": "Lymphocytes | Fetus | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Lymphocytes | Fetus | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": 61.13311408027457, "identifiers": [{"i": "UMLS:C1516839", "l": "Endocrine-Stromal Cell", "d": [], "t": []}, {"i": "NCIT:C41608", "l": "Endocrine-Stromal Cell", "d": ["A cell that forms the supporting matrix of one of the glands that secretes substances into the blood or lymph."], "t": []}], "preferred_name": "Endocrine-Stromal Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 74.64805296934512, "identifiers": [{"i": "UMLS:C1708880", "l": "Malignant Goblet-Like Mucous Cell", "d": [], "t": []}, {"i": "NCIT:C47812", "l": "Malignant Goblet-Like Mucous Cell", "d": [], "t": []}], "preferred_name": "Malignant Goblet-Like Mucous Cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1955381", "l": "Spermatozoa.angled midpiece", "d": [], "t": []}], "preferred_name": "Spermatozoa.angled midpiece", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5707893", "l": "Lecilimogene Autotemcel", "d": [], "t": []}, {"i": "NCIT:C188589", "l": "Lecilimogene Autotemcel", "d": [], "t": []}], "preferred_name": "Lecilimogene Autotemcel", "taxa": []}
{"type": "biolink:Cell", "ic": 75.54735764213513, "identifiers": [{"i": "CL:0002429", "l": "CD69-positive double-positive thymocyte", "d": ["A double-positive thymocyte that is CD69-positive and has begun positive selection."], "t": []}], "preferred_name": "CD69-positive double-positive thymocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 83.63771255585968, "identifiers": [{"i": "UMLS:C1518307", "l": "Neutrophil with Cytoplasmic Hypogranularity", "d": [], "t": []}, {"i": "NCIT:C37174", "l": "Neutrophil with Cytoplasmic Hypogranularity", "d": [], "t": []}], "preferred_name": "Neutrophil with Cytoplasmic Hypogranularity", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0002339", "l": "prostate stem cell", "d": ["A prostate epithelial cell that is CD133-positive, CD44-positive, integrin A2beta3-high. This cell is a stem cell for the prostate epithelium."], "t": []}], "preferred_name": "prostate stem cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1440224", "l": "CD43.T-Cell monocyte+Myeloid cell", "d": [], "t": []}], "preferred_name": "CD43.T-Cell monocyte+Myeloid cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1267906", "l": "Lymphoblast positive for CD33 antigen", "d": [], "t": []}, {"i": "SNOMEDCT:117577003", "l": "", "d": [], "t": []}], "preferred_name": "Lymphoblast positive for CD33 antigen", "taxa": []}
{"type": "biolink:Cell", "ic": 84.83823963392128, "identifiers": [{"i": "UMLS:C1512993", "l": "Marginal Zone B-Lymphocyte of Nodal Type", "d": [], "t": []}, {"i": "NCIT:C38322", "l": "Marginal Zone B-Lymphocyte of Nodal Type", "d": ["A lymphocyte found in the marginal zones of lymph nodes. It has a naive B lymphoid lineage and plays an important role in the early phases of immune response with its ability to rapidly differentiate into an antibody secreting cell. These cells can directly activate T cells, interact with other antigen presenting cells, transporting and concentrating antigen during the course of T-dependent and T-independent immune responses."], "t": []}], "preferred_name": "Marginal Zone B-Lymphocyte of Nodal Type", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5855716", "l": "Autologous Anti-TM4SF1 CAR-T Cells", "d": [], "t": []}, {"i": "NCIT:C199625", "l": "Autologous Anti-TM4SF1 CAR-T Cells", "d": ["A preparation of autologous T-lymphocytes that have been genetically engineered to express a chimeric antigen receptor (CAR) specific for the tumor-associated antigen (TAA) transmembrane 4 L six family member 1 (TM4SF1) and containing a safety/kill switch composed of a truncated form of the human epidermal growth factor receptor (ErbB1t; EGFRt HER1t), with potential immunostimulating and antineoplastic activities. Upon administration, the autologous anti-TM4SF1 CAR-T cells specifically recognize and bind to TM4SF1-expressing tumor cells, resulting in tumor cell lysis. TM4SF1 plays a key role in the regulation of cell development, activation, growth and motility, and is overexpressed by a variety of tumor cells."], "t": []}], "preferred_name": "Autologous Anti-TM4SF1 CAR-T Cells", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5216199", "l": "Eosinophils.immature|NCnc|Pt|Bld", "d": [], "t": []}], "preferred_name": "Eosinophils.immature|NCnc|Pt|Bld", "taxa": []}
{"type": "biolink:Cell", "ic": 80.96785908349635, "identifiers": [{"i": "CL:0010005", "l": "atrioventricular bundle cell", "d": ["A specialized cardiomyocyte that transmit signals from the AV node to the cardiac Purkinje fibers."], "t": []}], "preferred_name": "atrioventricular bundle cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1516922", "l": "Mouse Epididymal Interstitial Cell", "d": [], "t": []}, {"i": "NCIT:C22171", "l": "Mouse Epididymal Interstitial Cell", "d": [], "t": []}], "preferred_name": "Mouse Epididymal Interstitial Cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C6063341", "l": "CD3+IgM- cell", "d": [], "t": []}, {"i": "SNOMEDCT:1373183003", "l": "", "d": [], "t": []}], "preferred_name": "CD3+IgM- cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1267835", "l": "Lymphocyte positive for both CD3 antigen and HLA-DR antigen", "d": [], "t": []}, {"i": "SNOMEDCT:117525009", "l": "", "d": [], "t": []}], "preferred_name": "Lymphocyte positive for both CD3 antigen and HLA-DR antigen", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5216211", "l": "Erythrocytes|NCnc|Pt|Body fld", "d": [], "t": []}], "preferred_name": "Erythrocytes|NCnc|Pt|Body fld", "taxa": []}
{"type": "biolink:Cell", "ic": 87.18682603146104, "identifiers": [{"i": "CL:0002196", "l": "hepatic oval stem cell", "d": ["A transient hepatic stem cell observed after liver injury with a high nuclear to cytoplasm ratio that can differentiate into mature hepatocytes and bile duct cells. Arises from more than one tissue."], "t": []}, {"i": "UMLS:C2336695", "l": "Hepatic oval stem cell", "d": [], "t": []}], "preferred_name": "hepatic oval stem cell", "taxa": []}
{"type": "biolink:Cell", "ic": 89.40238429118027, "identifiers": [{"i": "CL:0000636", "l": "Mueller cell", "d": ["Astrocyte-like radial glial cell that extends vertically throughout the retina, with the nucleus are usually in the middle of the inner nuclear layer."], "t": []}], "preferred_name": "Mueller cell", "taxa": []}
{"type": "biolink:Cell", "ic": 89.40238429118027, "identifiers": [{"i": "CL:0002049", "l": "fraction C precursor B cell", "d": ["A precursor B cell that is CD45R-positive, CD43-positive, CD24-positive, and BP-positive. Intracellularly expression of surrogate light chain, Rag1 and Rag2, TdT, occurs while there is no expression of mu heavy chain."], "t": []}], "preferred_name": "fraction C precursor B cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1261568", "l": "CD10+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:116749001", "l": "", "d": [], "t": []}], "preferred_name": "CD10+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": 49.06473286254507, "identifiers": [{"i": "UMLS:C4551752", "l": "Abnormal Lymphocyte cell", "d": [], "t": []}, {"i": "NCIT:C36725", "l": "Abnormal Lymphocyte", "d": ["A lymphocyte characterized by a structural or functional abnormality."], "t": []}], "preferred_name": "Abnormal Lymphocyte cell", "taxa": []}
{"type": "biolink:Cell", "ic": 87.18682603146104, "identifiers": [{"i": "CL:0000916", "l": "dendritic epidermal T cell", "d": ["A mature gamma-delta T cell located in the epidermis that regulates wound healing."], "t": []}], "preferred_name": "dendritic epidermal T cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C0017528", "l": "Giant Cells, Langhans", "d": [], "t": []}, {"i": "NCIT:C12562", "l": "Langhans Cell", "d": [], "t": []}, {"i": "MESH:D015744", "l": "Giant Cells, Langhans", "d": [], "t": []}, {"i": "SNOMEDCT:30938003", "l": "", "d": [], "t": []}], "preferred_name": "Giant Cells, Langhans", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C4289001", "l": "HPV-16 E7 TCR Expressing T-cells", "d": [], "t": []}, {"i": "NCIT:C128485", "l": "HPV-16 E7 TCR Expressing T-cells", "d": ["A preparation of allogeneic, genetically engineered T-lymphocytes transduced with a retroviral vector MSGV1 that encodes a T-cell receptor (TCR) targeting a specific epitope of the human papillomavirus (HPV) type 16 oncoprotein E7 (HPV-16 E7 TCR), with potential antineoplastic activity. The TCR especially recognizes and binds with high affinity to the HPV 16 E7 11-19 epitope. Upon administration, HPV-16 E7 expressing T-cells target and bind to tumor cells expressing the HPV-16 E7 antigen leading to selective cytotoxicity in HLA-A2-positive, HPV-16 E7-expressing tumor cells. HPV16 E7, a tumor-associated antigen (TAA), overexpressed in a variety of tumor cell types while not expressed in normal, healthy cells, plays a key role in tumor cell proliferation. E7 11-19 is a naturally processed epitope of HPV-16 E7 that binds specifically to human leukocyte antigen (HLA)-A*02:01 and that has been isolated from the surface of HPV-16 positive, HLA-A*02:01-positive tumor cells."], "t": []}], "preferred_name": "HPV-16 E7 TCR Expressing T-cells", "taxa": []}
{"type": "biolink:Cell", "ic": 57.81281684721655, "identifiers": [{"i": "UMLS:C1513971", "l": "Neoplastic Germ Cell", "d": [], "t": []}, {"i": "NCIT:C36903", "l": "Neoplastic Germ Cell", "d": [], "t": []}], "preferred_name": "Neoplastic Germ Cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4699464", "l": "Monotypic kappa plasma cells", "d": [], "t": []}], "preferred_name": "Monotypic kappa plasma cells", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0003046", "l": "M13 retinal ganglion cell", "d": ["A bistratifed retinal ganglion cell that has small, symmetric dendritic fields that terminate in S2 and S4."], "t": []}], "preferred_name": "M13 retinal ganglion cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1516687", "l": "Coactivated T Cell", "d": [], "t": []}, {"i": "NCIT:C12941", "l": "Coactivated T Cell", "d": [], "t": []}], "preferred_name": "Coactivated T Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 72.71882977221638, "identifiers": [{"i": "UMLS:C1513065", "l": "Neoplastic Medium-Sized B-Lymphocyte with Basophilic Cytoplasm", "d": [], "t": []}, {"i": "NCIT:C37005", "l": "Neoplastic Medium-Sized B-Lymphocyte with Basophilic Cytoplasm", "d": [], "t": []}], "preferred_name": "Neoplastic Medium-Sized B-Lymphocyte with Basophilic Cytoplasm", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5776766", "l": "RBC^Father", "d": [], "t": []}], "preferred_name": "RBC^Father", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4322735", "l": "CD20+ B lymphocyte", "d": [], "t": []}], "preferred_name": "CD20+ B lymphocyte", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1267810", "l": "Lymphocyte positive for CD1 antigen", "d": [], "t": []}, {"i": "SNOMEDCT:116850005", "l": "", "d": [], "t": []}], "preferred_name": "Lymphocyte positive for CD1 antigen", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4307028", "l": "Astro-NT NN_1 Galnt15 astrocyte (Mmus)", "d": ["A astrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Gfap (Mmus), Galnt15 (Mmus), Agt (Mmus). It is distinguished from other Astro-NT NN_1 cells by expression of Galnt15. These cells are located in the Cerebellum, brain , in or close to the regions: arbor vitae . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5208 Astro-NT NN_1."], "t": []}], "preferred_name": "Astro-NT NN_1 Galnt15 astrocyte (Mmus)", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1440414", "l": "Cells.t(8;14)(q24;q32)(MYC,IGH)", "d": [], "t": []}], "preferred_name": "Cells.t(8;14)(q24;q32)(MYC,IGH)", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1524111", "l": "Mouse Erythrocyte", "d": [], "t": []}, {"i": "NCIT:C22566", "l": "Mouse Erythrocyte", "d": [], "t": []}], "preferred_name": "Mouse Erythrocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0009025", "l": "mesothelial cell of colon", "d": ["A mesothelial cell that is part of the colon."], "t": []}], "preferred_name": "mesothelial cell of colon", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4484158", "l": "Cells.chromosome 3 monosomy", "d": [], "t": []}], "preferred_name": "Cells.chromosome 3 monosomy", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C2362027", "l": "Frozen erythrocytes", "d": [], "t": []}], "preferred_name": "Frozen erythrocytes", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C4725769", "l": "Cord Blood-derived Expanded Allogeneic Natural Killer Cells", "d": [], "t": []}, {"i": "NCIT:C150483", "l": "Cord Blood-derived Expanded Allogeneic Natural Killer Cells", "d": ["A preparation of human umbilical cord blood (UCB)-derived and ex vivo-expanded allogeneic natural killer (NK) cells, with immunomodulating and cytotoxic activities. Upon infusion of the cord blood-derived expanded allogeneic NK cells, these cells recognize and bind to tumor cells, and secrete perforins, granzymes, and cytokines, which cause cancer cell lysis."], "t": []}], "preferred_name": "Cord Blood-derived Expanded Allogeneic Natural Killer Cells", "taxa": []}
{"type": "biolink:Cell", "ic": 87.18682603146104, "identifiers": [{"i": "CL:1001052", "l": "kidney cortex vein cell", "d": ["Any kidney venous blood vessel cell that is part of some renal cortex vein."], "t": []}], "preferred_name": "kidney cortex vein cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0009017", "l": "intestinal crypt stem cell of small intestine", "d": ["An intestinal stem cell that is located in the small intestine crypt of Liberkuhn. These stem cells reside at the bottom of crypts in the small intestine and are highly proliferative. They either differentiate into transit amplifying cells or self-renew to form new stem cells."], "t": []}], "preferred_name": "intestinal crypt stem cell of small intestine", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5177617", "l": "Platelets | Blood cord | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Platelets | Blood cord | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": 87.18682603146104, "identifiers": [{"i": "CL:0000517", "l": "macrophage derived foam cell", "d": ["A type of foam cell derived from a macrophage containing lipids in small vacuoles and typically seen in atherolosclerotic lesions, as well as other conditions."], "t": []}, {"i": "UMLS:C0016390", "l": "Foam Cells", "d": [], "t": []}, {"i": "NCIT:C12560", "l": "Foam Cell", "d": ["A type of macrophage that ingests low-density lipoproteins found in fatty deposits on blood vessel walls, resulting in a foamy appearance."], "t": []}, {"i": "MESH:D005487", "l": "Foam Cells", "d": [], "t": []}, {"i": "SNOMEDCT:16980002", "l": "", "d": [], "t": []}], "preferred_name": "macrophage derived foam cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5555864", "l": "Oncolytic Adenovirus ICOVIR5-infected Allogeneic Mesenchymal Stem Cells", "d": [], "t": []}], "preferred_name": "Oncolytic Adenovirus ICOVIR5-infected Allogeneic Mesenchymal Stem Cells", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5985782", "l": "Allogeneic Anti-EGFR CAR/HLA-A*02-gated Inhibitory Receptor-expressing T-lymphocytes A2B395", "d": [], "t": []}, {"i": "NCIT:C214776", "l": "Allogeneic Anti-EGFR CAR/HLA-A*02-gated Inhibitory Receptor-expressing T-lymphocytes A2B395", "d": ["A preparation of allogeneic T-lymphocytes that have been genetically modified to express a chimeric antigen receptor (CAR) specific for the epidermal growth factor receptor (EGFR; HER1; ErbB1), and a leukocyte immunoglobulin-like receptor 1 (LIR-1)-based inhibitory receptor specific for human leukocyte antigen (HLA)-A*02 (HLA-A*02), with potential immunomodulating and antineoplastic activities. Upon administration, the allogeneic anti-EGFR CAR/HLA-A*02-gated inhibitory receptor-expressing T-lymphocytes A2B395 target and bind to EGFR-expressing tumor cells, thereby killing EGFR-expressing tumor cells that have loss of heterozygosity (LOH) for HLA-A*02 protein. The inhibitory receptor specific for HLA-A*02 acts as a self-regulated safety switch that blocks the killing of HLA-A*02-positive EGFR-expressing normal, healthy cells. This may also protect the normal, healthy cells from graft versus host disease (GvHD) resulting from the administration of the allogeneic T-cells. HLA-A*02 is expressed on normal cells but not on tumor cells due to LOH. EGFR, overexpressed by a variety of cancers, plays a key role in tumor cell proliferation and survival."], "t": []}], "preferred_name": "Allogeneic Anti-EGFR CAR/HLA-A*02-gated Inhibitory Receptor-expressing T-lymphocytes A2B395", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "UMLS:C1709192", "l": "Neoplastic Parathyroid Gland Water-Clear Cell", "d": [], "t": []}, {"i": "NCIT:C48625", "l": "Neoplastic Parathyroid Gland Water-Clear Cell", "d": [], "t": []}], "preferred_name": "Neoplastic Parathyroid Gland Water-Clear Cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5183792", "l": "Transitional cells | Urine | Urinalysis", "d": [], "t": []}], "preferred_name": "Transitional cells | Urine | Urinalysis", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4696688", "l": "CD19+CD27+IgD-IgM+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:1373237001", "l": "", "d": [], "t": []}], "preferred_name": "CD19+CD27+IgD-IgM+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": 82.62268137420203, "identifiers": [{"i": "UMLS:C1709210", "l": "Neoplastic Vacuolated Stromal Cell", "d": [], "t": []}, {"i": "NCIT:C54090", "l": "Neoplastic Vacuolated Stromal Cell", "d": [], "t": []}], "preferred_name": "Neoplastic Vacuolated Stromal Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4052012", "l": "interna theca cell", "d": ["A specialized theca cell that forms the inner, highly vascularized layer of the theca surrounding ovarian follicles. Originating from progenitor theca cells, the theca interna cell is steroidogenic, playing a crucial role in the production of androgens, which serves as a precursor for estrogen synthesis in granulosa cells. This cell expresses luteinizing hormone receptors, enabling it to respond to hormonal signals that regulate steroidogenesis."], "t": []}], "preferred_name": "interna theca cell", "taxa": []}
{"type": "biolink:Cell", "ic": 72.9312568671559, "identifiers": [{"i": "UMLS:C1514054", "l": "Neoplastic Oncocyte", "d": [], "t": []}, {"i": "NCIT:C36941", "l": "Neoplastic Oncocyte", "d": [], "t": []}], "preferred_name": "Neoplastic Oncocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 68.98930312440238, "identifiers": [{"i": "UMLS:C1708904", "l": "Malignant Rhabdomyoblast", "d": [], "t": []}, {"i": "NCIT:C49198", "l": "Malignant Rhabdomyoblast", "d": [], "t": []}], "preferred_name": "Malignant Rhabdomyoblast", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "CL:4023045", "l": "medulla-projecting glutamatergic neuron of the primary motor cortex", "d": ["An extratelencephalic-projecting glutamatergic neuron located in layer 5b of the primary motor cortex that projects to the medulla. MY ET cells are large, big-tufted cells with the apical dendrite often bifurcating close to the soma, suggesting they are corticospinal cells. MY ET cells have bigger hyperpolarization sag, lower input resistance, and smaller AP width, compared to L5 IT neurons."], "t": []}], "preferred_name": "medulla-projecting glutamatergic neuron of the primary motor cortex", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C3896577", "l": "LMP1/BARF1/EBNA1-specific Cytotoxic T-lymphocytes", "d": [], "t": []}, {"i": "NCIT:C118956", "l": "LMP1/BARF1/EBNA1-specific Cytotoxic T-lymphocytes", "d": ["A preparation of allogeneic cytotoxic T-lymphocytes (CTL) made specifically reactive to three Epstein-Barr virus (EBV) proteins, latent membrane protein (LMP) 1, BamH1-A rightward frame-1 (BARF1) and EBV nuclear antigen 1 (EBNA1), with potential antineoplastic activity. Administration of LMP1/BARF1/ EBNA1-specific CTLs to patients with LMP1/BARF1/EBNA1-positive tumors may result in a specific CTL response against the tumor cells expressing these antigens, which can result in both cell lysis and the inhibition of tumor cell proliferation. LMP1, BARF1 and EBNA1 are expressed in various, EBV-associated malignancies, including nasopharyngeal cancer and EBV-positive Hodgkin lymphoma."], "t": []}], "preferred_name": "LMP1/BARF1/EBNA1-specific Cytotoxic T-lymphocytes", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:1000445", "l": "myoepithelial cell of dilator pupillae", "d": ["A myoepithelial cell that is part of the dilatator pupillae."], "t": []}, {"i": "UMLS:C1182658", "l": "Myoepithelial cell of dilator pupillae", "d": [], "t": []}], "preferred_name": "myoepithelial cell of dilator pupillae", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5154475", "l": "Basophils | Blood cord | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Basophils | Blood cord | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5446899", "l": "Anti-CD20/Anti-CD22 CAR T-cells", "d": [], "t": []}, {"i": "NCIT:C175977", "l": "Anti-CD20/Anti-CD22 CAR T-cells", "d": ["A preparation of human T-lymphocytes engineered to express chimeric antigen receptors (CARs) specific for the tumor-associated antigens (TAAs) cluster of differentiation 20 (CD20) and CD22, with potential immunostimulating and antineoplastic activities. Upon administration, the anti-CD20/anti-CD22 CAR T-cells target and bind to both CD20 and CD22 expressed on the surface of tumor cells. This induces selective toxicity in tumor cells expressing these TAAs. CD20 and CD22 are overexpressed in certain hematologic malignancies."], "t": []}], "preferred_name": "Anti-CD20/Anti-CD22 CAR T-cells", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C3825466", "l": "Paraneurons", "d": [], "t": []}], "preferred_name": "Paraneurons", "taxa": []}
{"type": "biolink:Cell", "ic": 83.63771255585968, "identifiers": [{"i": "CL:1001603", "l": "lung macrophage", "d": ["Circulating macrophages and tissue macrophages (alveolar macrophages) of lung."], "t": []}], "preferred_name": "lung macrophage", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4030004", "l": "thymic nurse cell", "d": ["A large epithelial cell found in the thymus. This cell type may internalize thymocytes through extensions of plasma membrane. The cell surface and cytoplasmic vacuoles of a thymic nurse cell express MHC Class I and MHC Class II antigens. The interaction of these antigens with a developing thymocyte determines whether the thymocyte undergoes positive or negative selection."], "t": []}], "preferred_name": "thymic nurse cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1444183", "l": "Cleidoic ovum", "d": [], "t": []}], "preferred_name": "Cleidoic ovum", "taxa": []}
{"type": "biolink:Cell", "ic": 79.64650900338474, "identifiers": [{"i": "CL:0000840", "l": "immature conventional dendritic cell", "d": ["An immature cell of the conventional dendritic cell lineage, characterized by high levels of antigen uptake via endocytosis, macropinocytosis, and phagocytosis, and typically found resident in the tissues. Markers for this cell are CD80-low, CD86-low, and MHC-II-low."], "t": []}], "preferred_name": "immature conventional dendritic cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0945916", "l": "CD11b+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:1372827007", "l": "", "d": [], "t": []}], "preferred_name": "CD11b+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C0221280", "l": "Elliptocyte (cell)", "d": [], "t": []}, {"i": "NCIT:C206314", "l": "Pencil Cell", "d": ["A rod-shaped erythrocyte seen in iron deficiency anemia. They typically have long axes at least triple the length of the cell's short axis."], "t": []}, {"i": "SNOMEDCT:45028007", "l": "", "d": [], "t": []}, {"i": "SNOMEDCT:57882002", "l": "", "d": [], "t": []}, {"i": "SNOMEDCT:739028009", "l": "", "d": [], "t": []}], "preferred_name": "Elliptocyte (cell)", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0882934", "l": "CD8+CD38+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:1373051006", "l": "", "d": [], "t": []}], "preferred_name": "CD8+CD38+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4070014", "l": "pyloric motor neuron", "d": ["A motor neuron that controls pyloric filter movements; innervates the pyloric muscle."], "t": []}], "preferred_name": "pyloric motor neuron", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C4763759", "l": "Expanded/Activated Gamma Delta T-cells", "d": [], "t": []}, {"i": "NCIT:C157634", "l": "Expanded/Activated Gamma Delta T-cells", "d": ["A preparation of gamma delta T-lymphocytes derived from donor T-cells that have been expanded and activated ex-vivo and further depleted of alpha and beta T-cell receptors (TCRs), with potential immunomodulating and antineoplastic activities. Upon administration, these expanded/activated gamma delta (EAGD) T-cells secrete interferon-gamma (IFN-g) and exert direct killing of tumor cells. In addition, these cells activate the immune system to exert a cytotoxic T-lymphocyte (CTL) response against tumor cells. Gamma delta T-lymphocytes play a key role in the activation of the immune system and do not require major histocompatibility complex (MHC)-mediated antigen presentation to exert their cytotoxic effect."], "t": []}], "preferred_name": "Expanded/Activated Gamma Delta T-cells", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4023090", "l": "small basket cell", "d": ["A basket cell with axonal arbors composed of frequent, short, curvy axonal branches that tend to be near their somata and within the same layer."], "t": []}], "preferred_name": "small basket cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0004121", "l": "retinal ganglion cell B2", "d": ["A retinal ganglion cell B that has a very small but very dense dendritic field, and has post synaptic terminals in S2."], "t": []}], "preferred_name": "retinal ganglion cell B2", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C3871166", "l": "2000 erythrocytes", "d": [], "t": []}], "preferred_name": "2000 erythrocytes", "taxa": []}
{"type": "biolink:Cell", "ic": 55.63930344107435, "identifiers": [{"i": "CL:0002372", "l": "myotube", "d": ["A transversely striated, multinucleated syncytial muscle cell, formed by the fusion of myoblasts during muscle development."], "t": []}], "preferred_name": "myotube", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C3897252", "l": "Umbilical Cord Blood-derived Natural Killer Cells", "d": [], "t": []}, {"i": "NCIT:C118949", "l": "Umbilical Cord Blood-derived Natural Killer Cells", "d": ["A population of allogeneic, cytokine-differentiated, highly lytic natural killer (NK) cells derived from CD34+ cells isolated from human umbilical cord blood (UCB) with potential cytotoxic activity. CD34+ hematopoietic stem cells (HSC) are isolated from human UCB mononuclear cells, differentiated into mature, highly lytic, CD3- CD56+ NK cells, by a specific combination of cytokines that includes stem cell factor (SCF), fms-related tyrosine kinase 3 ligand (Flt3-L), interleukin-15 (IL-15) and insulin-like growth factor-1 (IGF-1), and expanded ex vivo. Upon administration, the UCB-derived NK cells may lyse cancer cells."], "t": []}], "preferred_name": "Umbilical Cord Blood-derived Natural Killer Cells", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0002099", "l": "type I cell of adrenal cortex", "d": ["A small, polyhedral, cell found in rounded groups or curved columns with deeply staining nuclei, scanty basophilic cytoplasm and a few lipid droplets. This cell in the zona glomerulosa produces mineralocorticoids."], "t": []}, {"i": "UMLS:C2327016", "l": "Type I cell of adrenal cortex", "d": [], "t": []}], "preferred_name": "type I cell of adrenal cortex", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1545464", "l": "Cells.t(2;13)(q36.1;q14.4)(PAX3,FOXO1)", "d": [], "t": []}], "preferred_name": "Cells.t(2;13)(q36.1;q14.4)(PAX3,FOXO1)", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5157492", "l": "CD34 blasts | XXX | Cell markers", "d": [], "t": []}], "preferred_name": "CD34 blasts | XXX | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5157557", "l": "CD4+CD95+ cells | Blood | Cell markers", "d": [], "t": []}], "preferred_name": "CD4+CD95+ cells | Blood | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "CL:0000919", "l": "CD8-positive, CD25-positive, alpha-beta regulatory T cell", "d": ["A CD8-positive alpha beta-positive T cell with the phenotype FoxP3-positive and having suppressor function."], "t": []}], "preferred_name": "CD8-positive, CD25-positive, alpha-beta regulatory T cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C4055459", "l": "Anti-GPC3-CAR Autologous T Lymphocytes", "d": [], "t": []}, {"i": "NCIT:C121638", "l": "Anti-GPC3-CAR Autologous T Lymphocytes", "d": ["A preparation of autologous T-lymphocytes that have been genetically modified to express a chimeric antigen receptor (CAR) specific for glypican-3 (GPC3), with potential immunostimulating and antineoplastic activities. Upon administration, anti-GPC3-CAR autologous T-lymphocytes specifically target and bind to GPC3-expressing tumor cells, resulting in tumor cell lysis. GPC3, a heparan sulfate proteoglycan and a member of the glypican family, is overexpressed on certain tumor cell types while minimally expressed in normal, healthy cells; GPC3 plays an important role in cellular proliferation and differentiation."], "t": []}], "preferred_name": "Anti-GPC3-CAR Autologous T Lymphocytes", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "CL:2000036", "l": "anterior lateral line neuromast supporting cell", "d": ["Any neuromast support cell that is part of a anterior lateral line."], "t": []}], "preferred_name": "anterior lateral line neuromast supporting cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1979744", "l": "Leukocytes.CD59 deficient", "d": [], "t": []}], "preferred_name": "Leukocytes.CD59 deficient", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C2338017", "l": "Neuron of retina", "d": [], "t": []}], "preferred_name": "Neuron of retina", "taxa": []}
{"type": "biolink:Cell", "ic": 76.40371442623734, "identifiers": [{"i": "CL:0000459", "l": "noradrenergic cell", "d": ["A cell capable of producting norepiniphrine. Norepiniphrine is a catecholamine with multiple roles including as a hormone and a neurotransmitter. In addition, epiniphrine is synthesized from norepiniphrine by the actions of the phenylethanolamine N-methyltransferase enzyme."], "t": []}], "preferred_name": "noradrenergic cell", "taxa": []}
{"type": "biolink:Cell", "ic": 79.07356789860069, "identifiers": [{"i": "CL:1000615", "l": "kidney cortex tubule cell", "d": ["Any kidney tubule cell that is part of some renal cortex tubule."], "t": []}], "preferred_name": "kidney cortex tubule cell", "taxa": []}
{"type": "biolink:Cell", "ic": 72.0250656653823, "identifiers": [{"i": "UMLS:C1711178", "l": "Bronchial Epithelial Cell", "d": [], "t": []}, {"i": "NCIT:C54242", "l": "Bronchial Epithelial Cell", "d": [], "t": []}], "preferred_name": "Bronchial Epithelial Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 77.82747199602274, "identifiers": [{"i": "UMLS:C0014793", "l": "Abnormal Red Blood Cell", "d": [], "t": []}, {"i": "NCIT:C12522", "l": "Abnormal Red Blood Cell", "d": [], "t": []}, {"i": "MESH:D004913", "l": "Erythrocytes, Abnormal", "d": [], "t": []}, {"i": "SNOMEDCT:397019006", "l": "", "d": [], "t": []}], "preferred_name": "Abnormal Red Blood Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 66.49986282425168, "identifiers": [{"i": "CL:4033054", "l": "perivascular cell", "d": ["A cell that is adjacent to a vessel. A perivascular cell plays a crucial role in maintaining vascular function and tissue homeostasis. This cell type regulates vessel integrity and flow dynamics."], "t": []}], "preferred_name": "perivascular cell", "taxa": []}
{"type": "biolink:Cell", "ic": 71.93166454101878, "identifiers": [{"i": "UMLS:C1513931", "l": "Neoplastic Basaloid Cell", "d": [], "t": []}, {"i": "NCIT:C36759", "l": "Neoplastic Basaloid Cell", "d": [], "t": []}], "preferred_name": "Neoplastic Basaloid Cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5572244", "l": "Siderocytes | Blood or Marrow | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Siderocytes | Blood or Marrow | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4052071", "l": "quiescent fibroblast", "d": ["A fibroblast in a quiescent state, characterized by a smaller, spindle-shaped morphology with a relatively small cytoplasm, modest rough endoplasmic reticulum and condensed chromatin. Despite low proliferation and contractility, it maintains high metabolic activity for extracellular-matrix homeostasis through continuous matrix protein turnover and mechanosensitive signaling. This cell can rapidly differentiate into contractile myofibroblasts under injury or inflammatory cues to drive tissue repair."], "t": []}], "preferred_name": "quiescent fibroblast", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1440354", "l": "CD77+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:1372931000", "l": "", "d": [], "t": []}], "preferred_name": "CD77+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5216223", "l": "Large unstained cells|NCnc|Pt|Bld", "d": [], "t": []}], "preferred_name": "Large unstained cells|NCnc|Pt|Bld", "taxa": []}
{"type": "biolink:Cell", "ic": 92.76600187037766, "identifiers": [{"i": "CL:0002213", "l": "white muscle cell", "d": ["A muscle cell with low content of myoglobin and other oxygen storing proteins. This muscle cell has a white appearance."], "t": []}], "preferred_name": "white muscle cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0000882", "l": "thymic medullary macrophage", "d": ["A thymic macrophage found in the thymic medulla."], "t": []}], "preferred_name": "thymic medullary macrophage", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C0228089", "l": "Protoplasmic astrocyte", "d": [], "t": []}, {"i": "NCIT:C33415", "l": "Protoplasmic Astrocyte", "d": [], "t": []}, {"i": "SNOMEDCT:4328003", "l": "", "d": [], "t": []}], "preferred_name": "Protoplasmic astrocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 85.53200374075534, "identifiers": [{"i": "CL:0000821", "l": "B-1b B cell", "d": ["A B-1 B cell that has the phenotype CD5-negative, but having other phenotypic attributes of a B-1 B cell."], "t": []}], "preferred_name": "B-1b B cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1265905", "l": "Oat cell", "d": [], "t": []}, {"i": "NCIT:C36762", "l": "Oat Cell", "d": [], "t": []}, {"i": "SNOMEDCT:125409002", "l": "", "d": [], "t": []}], "preferred_name": "Oat cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0947286", "l": "CD14+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:116752009", "l": "", "d": [], "t": []}], "preferred_name": "CD14+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C2698278", "l": "Autologous Anti-PSMA Gene-Modified T-Lymphocytes", "d": [], "t": []}, {"i": "NCIT:C78197", "l": "Autologous Anti-PSMA Gene-Modified T-Lymphocytes", "d": ["Autologous prostate specific membrane antigen (PSMA) gene-modified T lymphocytes with potential antineoplastic activity. Human autologous T-lymphocytes are isolated and transduced ex vivo with a retrovirus encoding a chimeric immune receptor (CIR) consisting of an antibody fragment against PSMA fused with signaling domains of the T cell. Upon reintroduction into the patient, autologous anti-PSMA gene-modified T-cells bind to PSMA-expressing prostate cancer cells, which may result in specific cytotoxic T-lymphocyte (CTL) tumor cell killing."], "t": []}], "preferred_name": "Autologous Anti-PSMA Gene-Modified T-Lymphocytes", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0178708", "l": "immortalized cell", "d": [], "t": []}], "preferred_name": "immortalized cell", "taxa": []}
{"type": "biolink:Cell", "ic": 90.871710685482, "identifiers": [{"i": "CL:0002341", "l": "basal cell of prostate epithelium", "d": ["An undifferentiated cell of the prostate epithelium that lacks secretory activity."], "t": []}], "preferred_name": "basal cell of prostate epithelium", "taxa": []}
{"type": "biolink:Cell", "ic": 92.76600187037766, "identifiers": [{"i": "CL:4033089", "l": "atretic follicular cell of ovary", "d": ["A follicular cell of ovary that has begun to degenerate and undergo atresia, a specialized apoptosis. This cell is found in an atretic follicle, which is an ovarian follicle that started to mature but failed to reach full development and instead regresses."], "t": []}], "preferred_name": "atretic follicular cell of ovary", "taxa": []}
{"type": "biolink:Cell", "ic": 88.20185721311867, "identifiers": [{"i": "UMLS:C1883692", "l": "Small to Medium Size Adenocarcinoma Cell with Oval Nucleus", "d": [], "t": []}, {"i": "NCIT:C62176", "l": "Small to Medium Size Adenocarcinoma Cell with Oval Nucleus", "d": [], "t": []}], "preferred_name": "Small to Medium Size Adenocarcinoma Cell with Oval Nucleus", "taxa": []}
{"type": "biolink:Cell", "ic": 77.60424150429895, "identifiers": [{"i": "CL:0000767", "l": "basophil", "d": ["Any of the immature or mature forms of a granular leukocyte that in its mature form has an irregularly shaped, pale-staining nucleus that is partially constricted into two lobes, and with cytoplasm that contains coarse, bluish-black granules of variable size. Basophils contain vasoactive amines such as histamine and serotonin, which are released on appropriate stimulation. A basophil is CD123-positive, CD193-positive, CD203c-positive, and FceRIa-positive."], "t": []}, {"i": "UMLS:C0004827", "l": "Basophils", "d": [], "t": []}, {"i": "NCIT:C12531", "l": "Basophil", "d": [], "t": []}, {"i": "MESH:D001491", "l": "Basophils", "d": [], "t": []}], "preferred_name": "basophil", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4033075", "l": "cycling CD4-positive, alpha-beta T cell", "d": ["A(n) CD4-positive, alpha-beta T cell that is cycling."], "t": []}], "preferred_name": "cycling CD4-positive, alpha-beta T cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C4684830", "l": "Autologous Anti-BCMA-CAR-expressing CD4+/CD8+ T-lymphocytes FCARH143", "d": [], "t": []}, {"i": "NCIT:C142807", "l": "Autologous Anti-BCMA-CAR-expressing CD4+/CD8+ T-lymphocytes FCARH143", "d": ["A preparation of ex vivo expanded autologous CD8+ and CD4+ T-cells that have been genetically modified to express a chimeric antigen receptor (CAR) specific for human B-cell maturation antigen (BCMA; tumor necrosis factor receptor superfamily member 17; TNFRSF17), with potential immunostimulating and antineoplastic activities. Upon administration, autologous anti-BCMA-CAR-expressing CD4+/CD8+ T-lymphocytes FCARH143 specifically recognize and induce selective toxicity in BCMA-expressing tumor cells. BCMA, a tumor specific antigen and a receptor for both a proliferation-inducing ligand (APRIL) and B-cell activating factor (BAFF), is a member of the tumor necrosis factor (TNF) receptor superfamily (TNFRSF) and plays a key role in plasma cell survival. BCMA is found on the surfaces of plasma cells and overexpressed on malignant plasma cells."], "t": []}], "preferred_name": "Autologous Anti-BCMA-CAR-expressing CD4+/CD8+ T-lymphocytes FCARH143", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5784958", "l": "Anti-interleukin-13 Receptor Alpha 2 CAR T Cells YYB-103", "d": [], "t": []}, {"i": "NCIT:C192172", "l": "Anti-interleukin-13 Receptor Alpha 2 CAR T Cells YYB-103", "d": ["A preparation of T-lymphocytes genetically modified to express a chimeric antigen receptors (CAR) specific for interleukin-13 receptor alpha 2 (IL13Ra2), with potential immunostimulating and antineoplastic activities. Upon administration, the anti-IL13Ra2 CAR T cells YYB-103 target and bind to IL13Ra2 expressed on the surface of tumor cells. This induces selective toxicity in tumor cells expressing IL13Ra2. IL13Ra2, a cancer-associated receptor, is overexpressed by a variety of tumor cell types including glioblastoma multiforme (GBM); it is associated with increased invasiveness of tumor cells."], "t": []}], "preferred_name": "Anti-interleukin-13 Receptor Alpha 2 CAR T Cells YYB-103", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C4053742", "l": "Anti-thyroglobulin mTCR-transduced Autologous Peripheral Blood Lymphocytes", "d": [], "t": []}, {"i": "NCIT:C121552", "l": "Anti-thyroglobulin mTCR-transduced Autologous Peripheral Blood Lymphocytes", "d": ["Peripheral blood lymphocytes (PBLs) transduced with a gene encoding for a thyroglobulin (TG)-specific murine T-cell receptor (mTCR), with potential antineoplastic activity. PBLs are harvested from a thyroid cancer patient, and transfected with a retroviral vector that encodes the mTCR gene specific for the human TG antigen. The transduced PBLs are then expanded in culture. When reintroduced to the patient, these anti-TG mTCR-expressing PBLs target and bind to TG-overexpressing tumor cells, which results in both cytokine secretion and tumor cell lysis. TG is a thyroid-specific protein."], "t": []}], "preferred_name": "Anti-thyroglobulin mTCR-transduced Autologous Peripheral Blood Lymphocytes", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1267875", "l": "Lymphocyte positive for CD16 antigen", "d": [], "t": []}, {"i": "SNOMEDCT:117554003", "l": "", "d": [], "t": []}], "preferred_name": "Lymphocyte positive for CD16 antigen", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5179533", "l": "Reticulocytes.mid | Blood | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Reticulocytes.mid | Blood | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0000754", "l": "type 2 cone bipolar cell (sensu Mus)", "d": ["An OFF-bipolar neuron found in the retina and having connections with cone photoreceptors cells and neurons in the outer half of the inner plexiform layer. The dendritic tree is not well filled and the dendrites are more delicate than in type 1 cells. The axon terminal is bushier and exhibits a dense plexus of varicosities in the inner part of sublamina 1 (Ghosh et al., 2004).  It can be differentiated from other retinal bipolar neurons by its expression of marker genes: Neto1, Lhx3 and Irx-6 (Shekhar, 2016)."], "t": []}], "preferred_name": "type 2 cone bipolar cell (sensu Mus)", "taxa": []}
{"type": "biolink:Cell", "ic": 87.18682603146104, "identifiers": [{"i": "CL:0002153", "l": "corneocyte", "d": ["The dead keratin-filled squamous cell of the stratum corneum. This cell type lacks a nucleus."], "t": []}, {"i": "UMLS:C1180925", "l": "Corneocyte", "d": [], "t": []}], "preferred_name": "corneocyte", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4038460", "l": "Non-hematopoietic stem cell", "d": [], "t": []}, {"i": "SNOMEDCT:725272001", "l": "", "d": [], "t": []}], "preferred_name": "Non-hematopoietic stem cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4033138", "l": "otic ganglion VIP neuron", "d": ["A parasympathetic neuron that has the soma located in the otic ganglion and expresses the marker vasoactive intestinal peptide (VIP)."], "t": []}], "preferred_name": "otic ganglion VIP neuron", "taxa": []}
{"type": "biolink:Cell", "ic": 88.20185721311867, "identifiers": [{"i": "UMLS:C1709206", "l": "Neoplastic Stellate Chondrocyte", "d": [], "t": []}, {"i": "NCIT:C53472", "l": "Neoplastic Stellate Chondrocyte", "d": [], "t": []}], "preferred_name": "Neoplastic Stellate Chondrocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0002127", "l": "innate effector T cell", "d": ["A T cell with a receptor of limited diversity that is capable of immediate effector functions upon stimulation."], "t": []}], "preferred_name": "innate effector T cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C6063209", "l": "CD16c+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:1372856007", "l": "", "d": [], "t": []}], "preferred_name": "CD16c+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4038488", "l": "Cervical cells.overexpressing HPV E6+E7 mRNA", "d": [], "t": []}], "preferred_name": "Cervical cells.overexpressing HPV E6+E7 mRNA", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0806987", "l": "Mononuclear cells", "d": [], "t": []}], "preferred_name": "Mononuclear cells", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1507335", "l": "Ciliated columnar lining cells", "d": [], "t": []}], "preferred_name": "Ciliated columnar lining cells", "taxa": []}
{"type": "biolink:Cell", "ic": 65.91676802607104, "identifiers": [{"i": "UMLS:C1518272", "l": "Neuroectodermal Cell", "d": [], "t": []}, {"i": "NCIT:C42050", "l": "Neuroectodermal Cell", "d": ["An embryonic cell on the dorsal surface of the early vertebrate embryo that gives rise to the cells of the nervous system"], "t": []}], "preferred_name": "Neuroectodermal Cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5157470", "l": "CD3+HLA-DR+ cells | XXX | Cell markers", "d": [], "t": []}], "preferred_name": "CD3+HLA-DR+ cells | XXX | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": 74.50942324134168, "identifiers": [{"i": "CL:0000898", "l": "naive T cell", "d": ["Mature T cell not yet exposed to antigen with the phenotype CCR7-positive, CD45RA-positive, and CD127-positive. This cell type is also described as being CD25-negative, CD62L-high and CD44-low."], "t": []}], "preferred_name": "naive T cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5854451", "l": "Autologous Anti-CD19/CD20 Bispecific CAR-T Cells IMPT-314", "d": [], "t": []}], "preferred_name": "Autologous Anti-CD19/CD20 Bispecific CAR-T Cells IMPT-314", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5963423", "l": "Autologous Anti-mesothelin M28z1XXPD1DNR CAR-expressing T-cells", "d": [], "t": []}, {"i": "NCIT:C210957", "l": "Autologous Anti-mesothelin M28z1XXPD1DNR CAR-expressing T-cells", "d": ["A preparation of autologous T-lymphocytes that have been genetically modified to express a chimeric antigen receptor (CAR) specific for the human tumor-associated antigen (TAA) mesothelin (MSLN) linked to the signaling domains for the co-stimulatory molecules CD28 and CD3 zeta, as well as a PD-1 dominant negative receptor (DNR), with potential immunomodulating and antineoplastic activities. Upon administration, the autologous anti-MSLN M28z1XXPD1DNR CAR-expressing T-cells specifically target and kill MSLN-expressing tumor cells. MSLN, a cell surface glycoprotein involved in cell adhesion, is overexpressed in a variety of cancer cell types. PD-1, an immune checkpoint receptor expressed on T-cells, plays a key role in tumor immune evasion by binding to its ligand programmed death ligand 1 (PD-L1; cluster of differentiation 274; CD274; programmed cell death-1 ligand 1) expressed on tumor cells. PD-1 DNR lacks the PD-1 transmembrane and intracellular signaling domains and acts as a decoy receptor, thereby blocking PD-1-mediated signaling. This may decrease T-cell exhaustion and may enhance T-cell activity against MSLN-expressing tumor cells."], "t": []}], "preferred_name": "Autologous Anti-mesothelin M28z1XXPD1DNR CAR-expressing T-cells", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0002267", "l": "type D cell of stomach", "d": ["A type D cell found in the stomach."], "t": []}, {"i": "UMLS:C2328822", "l": "Type D cell of stomach", "d": [], "t": []}], "preferred_name": "type D cell of stomach", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0000204", "l": "acceleration receptive cell", "d": [], "t": []}], "preferred_name": "acceleration receptive cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C6053234", "l": "Autologous Anti-PHOX2B Peptide-centric CAR T-cells", "d": [], "t": []}, {"i": "NCIT:C220615", "l": "Autologous Anti-PHOX2B Peptide-centric CAR T-cells", "d": ["A preparation of autologous T-lymphocytes that have been genetically modified to express a chimeric antigen receptor (CAR) specific for the paired mesoderm homeobox protein 2B (PHOX2B) peptide-major histocompatibility complex (p-HLA), with potential immunostimulating and antineoplastic activities. Upon administration, autologous anti-PHOX2B peptide-centric (PC) CAR T-cells specifically recognize and induce selective toxicity in PHOX2B-expressing tumor cells. PHOX2B, a transcription factor that regulates the differentiation of neural crest cells, is overexpressed in neuroblastoma and has limited expression in normal tissue after birth. The PC CAR T-cells recognize PHOX2B tumor peptides across multiple HLA allotypes across the population."], "t": []}], "preferred_name": "Autologous Anti-PHOX2B Peptide-centric CAR T-cells", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4052023", "l": "luminal endometrial unciliated epithelial cell", "d": ["An epithelial cell that is part of the endometrial luminal epithelium, forming a continuous layer lining the uterine cavity. This cell undergoes cyclical changes during the menstrual cycle, proliferating under estrogen in the proliferative phase, and differentiating under progesterone in the secretory phase to prepare for potential implantation. During the window of implantation, this cell changes from a tall columnar shape to a shorter columnar or cuboidal form, loses polarity, and becomes receptive to blastocyst implantation."], "t": []}], "preferred_name": "luminal endometrial unciliated epithelial cell", "taxa": []}
{"type": "biolink:Cell", "ic": 90.871710685482, "identifiers": [{"i": "CL:4033057", "l": "luminal adaptive secretory precursor cell of mammary gland", "d": ["A luminal epithelial cell of the mammary gland that can proliferate and has the potential to differentiate into a lactocyte during pregnancy. In humans, a luminal adaptive secretory precursor cell can be identified by high levels of the markers EpCAM and CD49f, and in mice it can be identified by low levels of CD29 and high levels of CD14, Kit, CD61, and Tspan8."], "t": []}], "preferred_name": "luminal adaptive secretory precursor cell of mammary gland", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5853678", "l": "Ex vivo expanded autologous human corneal epithelial cells containing stem cells", "d": [], "t": []}], "preferred_name": "Ex vivo expanded autologous human corneal epithelial cells containing stem cells", "taxa": []}
{"type": "biolink:Cell", "ic": 92.76600187037766, "identifiers": [{"i": "CL:0002507", "l": "langerin-positive lymph node dendritic cell", "d": ["A dermal dendritic cell isolated from skin draining lymph nodes that is langerin-positive, MHC-II-positive, and CD4-negative and CD8a-negative."], "t": []}], "preferred_name": "langerin-positive lymph node dendritic cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5966020", "l": "Anti-CD22-CAR m971-BBz Lentiviral Vector-transduced Autologous T Lymphocytes CRG-022", "d": [], "t": []}], "preferred_name": "Anti-CD22-CAR m971-BBz Lentiviral Vector-transduced Autologous T Lymphocytes CRG-022", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "UMLS:C1709188", "l": "Neoplastic Ovoid Mononuclear Stromal Cell", "d": [], "t": []}, {"i": "NCIT:C49053", "l": "Neoplastic Ovoid Mononuclear Stromal Cell", "d": [], "t": []}], "preferred_name": "Neoplastic Ovoid Mononuclear Stromal Cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0333806", "l": "Macrocytic normochromic erythrocyte", "d": [], "t": []}, {"i": "SNOMEDCT:7841003", "l": "", "d": [], "t": []}], "preferred_name": "Macrocytic normochromic erythrocyte", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5157543", "l": "CD4+CD45+ cells | Blood | Cell markers", "d": [], "t": []}], "preferred_name": "CD4+CD45+ cells | Blood | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": 92.76600187037766, "identifiers": [{"i": "CL:0002529", "l": "CD1a-positive dermal dendritic cell", "d": ["A dermal dendritic cell that is CD1a-positive and CD14-negative."], "t": []}], "preferred_name": "CD1a-positive dermal dendritic cell", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "UMLS:C1708882", "l": "Malignant Histiocyte-Like Cell", "d": [], "t": []}, {"i": "NCIT:C49051", "l": "Malignant Histiocyte-Like Cell", "d": [], "t": []}], "preferred_name": "Malignant Histiocyte-Like Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0002342", "l": "circulating endothelial cell", "d": ["A circulating endothelial cell of the phenotype CD146-positive, CD105-positive, CD45-negative. This cell type is indicative of recent vascular damage."], "t": []}, {"i": "UMLS:C3272886", "l": "Circulating Endothelial Cell Count", "d": [], "t": []}], "preferred_name": "circulating endothelial cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1267897", "l": "Lymphocyte positive for CD25 antigen", "d": [], "t": []}, {"i": "SNOMEDCT:116844000", "l": "", "d": [], "t": []}], "preferred_name": "Lymphocyte positive for CD25 antigen", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5157499", "l": "CD34+CD117+ blasts | XXX | Cell markers", "d": [], "t": []}], "preferred_name": "CD34+CD117+ blasts | XXX | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0002103", "l": "IgG-positive double negative memory B cell", "d": ["An IgG-positive double negative memory B cell is a double negative memory B cell with the phenotype IgG-positive, IgD-negative, and CD27-negative."], "t": []}], "preferred_name": "IgG-positive double negative memory B cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5853522", "l": "Autologous rapamycin-resistant Th1/Tc1 cells", "d": [], "t": []}], "preferred_name": "Autologous rapamycin-resistant Th1/Tc1 cells", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0947305", "l": "Erythrocytes.CD59", "d": [], "t": []}], "preferred_name": "Erythrocytes.CD59", "taxa": []}
{"type": "biolink:Cell", "ic": 80.27409497666227, "identifiers": [{"i": "UMLS:C1514020", "l": "Neoplastic Medium-Sized to Large T-Lymphocyte", "d": [], "t": []}, {"i": "NCIT:C39614", "l": "Neoplastic Medium-Sized to Large T-Lymphocyte", "d": [], "t": []}], "preferred_name": "Neoplastic Medium-Sized to Large T-Lymphocyte", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1182804", "l": "Epithelial cell of endocrine pancreas", "d": [], "t": []}], "preferred_name": "Epithelial cell of endocrine pancreas", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4706843", "l": "Indium (111-In) labeled granulocyte", "d": [], "t": []}, {"i": "SNOMEDCT:763410001", "l": "", "d": [], "t": []}], "preferred_name": "Indium (111-In) labeled granulocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 76.9766555310214, "identifiers": [{"i": "UMLS:C1881559", "l": "Malignant Hobnail Cell", "d": [], "t": []}, {"i": "NCIT:C61543", "l": "Malignant Hobnail Cell", "d": [], "t": []}], "preferred_name": "Malignant Hobnail Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1513176", "l": "Metaplastic Squamous Cell", "d": [], "t": []}, {"i": "NCIT:C36817", "l": "Metaplastic Squamous Cell", "d": [], "t": []}], "preferred_name": "Metaplastic Squamous Cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5157625", "l": "CD59 cells | Blood | Cell markers", "d": [], "t": []}], "preferred_name": "CD59 cells | Blood | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": 68.3133595125128, "identifiers": [{"i": "CL:4023111", "l": "cerebral cortex pyramidal neuron", "d": ["A pyramidal neuron with soma located in the cerebral cortex."], "t": []}], "preferred_name": "cerebral cortex pyramidal neuron", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C4724730", "l": "Autologous Mesothelin-specific CAR-T-Cells Expressing Anti-PD-1/CTLA-4 Antibodies", "d": [], "t": []}, {"i": "NCIT:C150682", "l": "Autologous Mesothelin-specific CAR-T-Cells Expressing Anti-PD-1/CTLA-4 Antibodies", "d": ["A preparation of autologous, engineered T-lymphocytes that express both a second-generation chimeric antigen receptor (CAR) specific for the human gastric carcinoma-associated antigen MG7, and the co-stimulatory molecule 4-1BB (CD137), with potential antineoplastic activity. Upon intratumoral injection, the autologous anti-MG7-CAR T-lymphocytes target and attach to cancer cells expressing MG7. This induces selective toxicity in and causes lysis of MG7-expressing tumor cells. MG7, a glycosylated protein sequence from the tumor-associated antigen (TAA) carcinoembryonic antigen (CEA), plays a key role in the development of certain tumor cell types. 4-1BB enhances T-cell activation and signaling after recognition of MG7."], "t": []}], "preferred_name": "Autologous Mesothelin-specific CAR-T-Cells Expressing Anti-PD-1/CTLA-4 Antibodies", "taxa": []}
{"type": "biolink:Cell", "ic": 87.18682603146104, "identifiers": [{"i": "CL:0004253", "l": "wide field retinal amacrine cell", "d": ["An amicrine that has a wide dendritic field."], "t": []}], "preferred_name": "wide field retinal amacrine cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C4744782", "l": "Autologous MCPyV-specific HLA-A02-restricted TCR-transduced CD4+ and CD8+ T-cells FH-MCVA2TCR", "d": [], "t": []}, {"i": "NCIT:C156382", "l": "Autologous MCPyV-specific HLA-A02-restricted TCR-transduced CD4+ and CD8+ T-cells FH-MCVA2TCR", "d": ["A preparation of autologous CD4+ and CD62L-expressing CD8+ T-cells transduced with a third generation lentiviral vector (LV) to express the high affinity T-cell receptor (TCR) A2 -MCC1, specific for the human leukocyte antigen (HLA)-A02-restricted Merkel cell polyomavirus (MCPyV; MCV) viral oncoprotein, with potential immunomodulating and antineoplastic activities. Upon reintroduction into the patient, the autologous MCPyV-specific HLA-A02-restricted TCR-transduced CD8+ and CD4+ T-cells FH-MCVA2TCR selectively bind to the KLLEIAPNC epitope (KLL epitope) within the MCPyV viral oncoprotein. This results in cytotoxic T-lymphocyte (CTL)-mediated elimination of tumor cells expressing the MCPyV viral oncoprotein. Additionally, tumor-specific HLA-A02-restricted CD4+ cells promote class I-restricted CD8+ proliferation, survival and effector functions by producing interleukin (IL)-2 and facilitating the activation of dendritic cells (DCs). MCPyV viral oncoprotein is highly expressed in Merkel cell carcinoma (MCC) caused by MCPyV."], "t": []}], "preferred_name": "Autologous MCPyV-specific HLA-A02-restricted TCR-transduced CD4+ and CD8+ T-cells FH-MCVA2TCR", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1956421", "l": "Neoplastic Stem Cells", "d": [], "t": []}, {"i": "MESH:D014411", "l": "Neoplastic Stem Cells", "d": [], "t": []}], "preferred_name": "Neoplastic Stem Cells", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1955383", "l": "Spermatozoa.isolated head", "d": [], "t": []}], "preferred_name": "Spermatozoa.isolated head", "taxa": []}
{"type": "biolink:Cell", "ic": 59.458332183916376, "identifiers": [{"i": "CL:0000058", "l": "chondroblast", "d": ["Skeletogenic cell that is typically non-terminally differentiated, secretes an avascular, GAG rich matrix; is not buried in cartilage tissue matrix, retains the ability to divide, located adjacent to cartilage tissue (including within the perichondrium), and develops from prechondroblast (and thus prechondrogenic) cell."], "t": []}], "preferred_name": "chondroblast", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1440347", "l": "CD66e+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:1372925003", "l": "", "d": [], "t": []}], "preferred_name": "CD66e+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4310085", "l": "striatal LAMP5 LHX6 GABAergic interneuron (Primate)", "d": ["A Lamp5 Lhx6 neuron of the Primates brain. These cells are located in the striatum . Reference transcriptomic data for this type can be found in the dataset/taxonomy - HMBA Basal Ganglia Consensus Taxonomy in cell set Group:LAMP5-LHX6 GABA."], "t": []}], "preferred_name": "striatal LAMP5 LHX6 GABAergic interneuron (Primate)", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5555556", "l": "CB-010", "d": [], "t": []}, {"i": "NCIT:C179255", "l": "Allogeneic CRISPR-edited Anti-CD19 CAR-T Cells CB-010", "d": ["A preparation of allogeneic, off-the-shelf T-lymphocytes genetically modified to express a chimeric antigen receptor (CAR) specific for the tumor-associated antigen (TAA) CD19, and clustered regularly interspaced short palindromic repeats (CRISPR)-edited to eliminate endogenous T-cell receptor (TCR) and programmed death 1 (PD-1; PDCD1; CD279; programmed cell death-1) expression, with potential immunostimulating and antineoplastic activities. Upon administration, the allogeneic CRISPR-edited anti-CD19 CAR-T cells CB-010 recognize and bind to CD19-expressing tumor cells. This may result in a specific cytotoxic T-lymphocyte (CTL)-mediated killing of CD19-positive tumor cells. PD-1, an immune checkpoint receptor expressed on T-cells, plays a key role in tumor immune evasion by binding to its ligand programmed death ligand 1 (PD-L1; cluster of differentiation 274; CD274; programmed cell death-1 ligand 1) expressed on tumor cells. By removing PD-1 from T-cells, PD-1-mediated signaling is halted which may decrease T-cell exhaustion and may enhance T-cell activity against the CD19-expressing tumor cells. The endogenous TCR is removed to prevent graft-versus-host disease (GvHD). CD19 antigen is a B-cell specific cell surface antigen overexpressed in B-cell lineage malignancies."], "t": []}], "preferred_name": "CB-010", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1267988", "l": "Lymphocyte positive for CD102 antigen", "d": [], "t": []}, {"i": "SNOMEDCT:117428009", "l": "", "d": [], "t": []}], "preferred_name": "Lymphocyte positive for CD102 antigen", "taxa": []}
{"type": "biolink:Cell", "ic": 47.03725525642213, "identifiers": [{"i": "UMLS:C0024264", "l": "Lymphocyte", "d": [], "t": []}, {"i": "NCIT:C12535", "l": "Lymphocyte", "d": ["White blood cells formed in the body's lymphoid tissue. The nucleus is round or ovoid with coarse, irregularly clumped chromatin while the cytoplasm is typically pale blue with azurophilic (if any) granules. Most lymphocytes can be classified as either T or B (with subpopulations of each); those with characteristics of neither major class are called null cells."], "t": []}, {"i": "MESH:D008214", "l": "Lymphocytes", "d": [], "t": []}, {"i": "SNOMEDCT:56972008", "l": "", "d": [], "t": []}], "preferred_name": "Lymphocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 89.40238429118027, "identifiers": [{"i": "CL:0002014", "l": "Kit-negative, Ly-76 high basophilic erythroblast", "d": ["A basophilic erythroblast that is Lyg 76-high and is Kit-negative."], "t": []}], "preferred_name": "Kit-negative, Ly-76 high basophilic erythroblast", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5216315", "l": "Promonocytes|NCnc|Pt|Bld", "d": [], "t": []}], "preferred_name": "Promonocytes|NCnc|Pt|Bld", "taxa": []}
{"type": "biolink:Cell", "ic": 70.98321298487613, "identifiers": [{"i": "UMLS:C1879552", "l": "Adenocarcinoma Cell with Abundant Cytoplasm", "d": [], "t": []}, {"i": "NCIT:C60433", "l": "Adenocarcinoma Cell with Abundant Cytoplasm", "d": [], "t": []}], "preferred_name": "Adenocarcinoma Cell with Abundant Cytoplasm", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0004213", "l": "type 3a cone bipolar cell", "d": ["A type of type 3 cone bipolar cell with distinctive curly dendrites."], "t": []}], "preferred_name": "type 3a cone bipolar cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0000485", "l": "mucosal type mast cell", "d": ["Mast cell subtype that contains only the serine protease trypase in its granules. These cells are primarily found in mucosal tissue, such as intestinal mucosa and alveoli. They depend upon T-cells for development of phenotype."], "t": []}], "preferred_name": "mucosal type mast cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C3899239", "l": "Exhausted T-Cell", "d": [], "t": []}, {"i": "NCIT:C120000", "l": "Exhausted T-Cell", "d": ["An effector T-lymphocyte that is losing or has lost the ability to kill virally infected cells. T-cell exhaustion occurs during infections with high viral loads and/or prolonged duration. These T-lymphocytes undergo a gradual phenotype change and in the final stage they are unable to mount a T-cell antiviral response and are highly susceptible to apoptosis."], "t": []}], "preferred_name": "Exhausted T-Cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5157300", "l": "CD135 blasts | Blood | Cell markers", "d": [], "t": []}], "preferred_name": "CD135 blasts | Blood | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": 92.76600187037766, "identifiers": [{"i": "CL:0002126", "l": "CD25-positive, CD27-positive immature gamma-delta T cell", "d": ["A CD25-positive, CD27-positive immature gamma-delta T cell found in the thymus that has an immature phenotype (i.e. CD24-high, CD25-high, CD62L-high, CD44-high, CD2-low, CD5-low)."], "t": []}], "preferred_name": "CD25-positive, CD27-positive immature gamma-delta T cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5706491", "l": "Autologous Anti-CD20CAR-CD28-4-1BB-CD3zeta T-lymphocytes MB-106", "d": [], "t": []}, {"i": "NCIT:C188358", "l": "Autologous Anti-CD20CAR-CD28-4-1BB-CD3zeta T-lymphocytes MB-106", "d": ["A preparation of autologous T-lymphocytes that have been transduced with a lentiviral vector expressing a chimeric antigen receptor (CAR) targeting the tumor-associated antigen (TAA) cluster of differentiation 20 (CD20) and coupled to the co-stimulatory signaling domain CD28, the signaling domain of 4-1BB (CD137), and the zeta chain of the T-cell receptor (TCR)/CD3 complex (CD3zeta), with potential immunostimulating and antineoplastic activities. Upon administration, autologous anti-CD20CAR-CD28-4-1BB-CD3zeta T-lymphocytes MB-106 specifically recognize and kill CD20-expressing tumor cells. The CD20 antigen, a non-glycosylated B-cell specific surface phosphoprotein that plays a role in the differentiation of B-cells into plasma cells, is overexpressed in B-cell lineage malignancies and certain melanoma cell subpopulations."], "t": []}], "preferred_name": "Autologous Anti-CD20CAR-CD28-4-1BB-CD3zeta T-lymphocytes MB-106", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1440307", "l": "CD41a+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:1372884002", "l": "", "d": [], "t": []}], "preferred_name": "CD41a+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5216251", "l": "Lymphocytes|NCnc|Pt|CSF", "d": [], "t": []}], "preferred_name": "Lymphocytes|NCnc|Pt|CSF", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5171667", "l": "Lymphocytes | Stool | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Lymphocytes | Stool | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5986003", "l": "Anti-DLL3 CAR-NK Cells SNC-115", "d": [], "t": []}, {"i": "NCIT:C215080", "l": "Anti-DLL3 CAR-NK Cells SNC-115", "d": ["A preparation of natural killer (NK) cells engineered to express a chimeric antigen receptor (CAR) specific for the tumor-associated antigen (TAA) delta-like protein 3 (DLL3), with potential immunomodulating and antineoplastic activities. Upon administration, anti-DLL3 CAR-NK cells SNC-115 recognize, bind to and induce selective cytotoxicity in DLL3-expressing tumor cells. DLL3, a Notch pathway protein, is overexpressed on a variety of cancer cell types. It plays a key role in embryonic development and in tumor initiation and proliferation."], "t": []}], "preferred_name": "Anti-DLL3 CAR-NK Cells SNC-115", "taxa": []}
{"type": "biolink:Cell", "ic": 67.27542511171934, "identifiers": [{"i": "CL:0008060", "l": "GABA-Glut neuron", "d": ["A neuron that releases both gamma-aminobutyric acid and glutamate as vesicular neurotransmitters."], "t": []}], "preferred_name": "GABA-Glut neuron", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1254548", "l": "Polychromatocyte", "d": [], "t": []}], "preferred_name": "Polychromatocyte", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0333827", "l": "Monocytoid cell", "d": [], "t": []}, {"i": "SNOMEDCT:35907002", "l": "", "d": [], "t": []}], "preferred_name": "Monocytoid cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1317495", "l": "Leukocyte clumps", "d": [], "t": []}], "preferred_name": "Leukocyte clumps", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0007012", "l": "non-terminally differentiated odontoblast", "d": ["Odontoblast that non-terminally differentiated, located in the odontogenic papilla and dentine tissue, and transforms from a odontoblast cell."], "t": []}], "preferred_name": "non-terminally differentiated odontoblast", "taxa": []}
{"type": "biolink:Cell", "ic": 69.94527858408269, "identifiers": [{"i": "CL:0000806", "l": "DN2 thymocyte", "d": ["A thymocyte that has the phenotype CD4-negative, CD8-negative, CD44-positive, and CD25-positive."], "t": []}], "preferred_name": "DN2 thymocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 83.11065783093733, "identifiers": [{"i": "UMLS:C1518240", "l": "Malignant Polygonal Cell with Abundant Granular Cytoplasm", "d": [], "t": []}, {"i": "NCIT:C36884", "l": "Malignant Polygonal Cell with Abundant Granular Cytoplasm", "d": [], "t": []}], "preferred_name": "Malignant Polygonal Cell with Abundant Granular Cytoplasm", "taxa": []}
{"type": "biolink:Cell", "ic": 72.8241867216765, "identifiers": [{"i": "CL:0000573", "l": "retinal cone cell", "d": ["One of the two photoreceptor cell types in the vertebrate retina. In cones the photopigment is in invaginations of the cell membrane of the outer segment. Cones are less sensitive to light than rods, but they provide vision with higher spatial and temporal acuity, and the combination of signals from cones with different pigments allows color vision."], "t": []}, {"i": "UMLS:C0206428", "l": "Retinal Cone", "d": [], "t": []}, {"i": "NCIT:C12637", "l": "Retinal Cone", "d": ["A photoreceptor cell located in the retina of the eye that allows high spatial acuity and color sensitivity."], "t": []}, {"i": "MESH:D017949", "l": "Retinal Cone Photoreceptor Cells", "d": [], "t": []}, {"i": "SNOMEDCT:67540009", "l": "", "d": [], "t": []}], "preferred_name": "retinal cone cell", "taxa": []}
{"type": "biolink:Cell", "ic": 56.02532862165879, "identifiers": [{"i": "CL:0017006", "l": "B-lymphoblast", "d": ["A lymphocyte of B lineage that has gotten larger after being stimulated by an antigen."], "t": []}, {"i": "UMLS:C1516097", "l": "B lymphoblast", "d": [], "t": []}, {"i": "NCIT:C33931", "l": "Precursor B-Lymphoblast", "d": ["A morphologically immature B-lymphocyte, once thought to represent an early stage in lymphocyte development but now known to be an activated lymphocyte that has been transformed in response to antigenic stimulation."], "t": []}], "preferred_name": "B-lymphoblast", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0546505", "l": "P.B. hemohistioblast", "d": [], "t": []}], "preferred_name": "P.B. hemohistioblast", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4047044", "l": "type 2 interganglionic glia", "d": ["An enteric glial cell that has an elongated, fibrous morphology with long processes that run parallel to nerve fibers connecting enteric myenteric ganglia. This cell is located in the interganglionic fiber tracts of the enteric nervous system."], "t": []}], "preferred_name": "type 2 interganglionic glia", "taxa": []}
{"type": "biolink:Cell", "ic": 81.743421370964, "identifiers": [{"i": "UMLS:C1711354", "l": "Malignant Mesenchymal Spindle Cell", "d": [], "t": []}, {"i": "NCIT:C49056", "l": "Malignant Mesenchymal Spindle Cell", "d": [], "t": []}], "preferred_name": "Malignant Mesenchymal Spindle Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5785424", "l": "Autologous HPV16/HPV18/Survivin-specific CD8+ T-cells NEXI-003", "d": [], "t": []}, {"i": "NCIT:C192801", "l": "Autologous HPV16/HPV18/Survivin-specific CD8+ T-cells NEXI-003", "d": ["A preparation of autologous CD3+ CD4- CD8+ T-cells targeting multiple human papilloma virus (HPV) tumor-associated antigens, including HPV types 16 and 18 antigens and survivin, with potential immunomodulating and antineoplastic activities. Following leukapheresis and ex vivo priming and expansion, the autologous HPV16/HPV18/survivin-specific CD8+ T-cells NEXI-003 are re-introduced into the patient, where they target and kill tumor cells expressing these HPV tumor-associated antigens."], "t": []}], "preferred_name": "Autologous HPV16/HPV18/Survivin-specific CD8+ T-cells NEXI-003", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5205410", "l": "Allogeneic CD34-positive Enriched Peripheral Blood Stem Cells", "d": [], "t": []}, {"i": "NCIT:C160626", "l": "Allogeneic CD34-positive Enriched Peripheral Blood Stem Cells", "d": ["A preparation of allogeneic CD34+ selected peripheral blood stem cells (PBSCs) that can potentially be used for immune reconstitution purposes. Upon administration of the allogeneic CD34-positive enriched PBSCs after a hematopoietic cell transplantation (HCT), these cells may provide memory T-cell (Tm) recovery and potentially prevent viral infections. They potentially reduce the occurrence of graft-versus-host disease (GvHD) without increasing the risk of graft failure or poor graft function."], "t": []}], "preferred_name": "Allogeneic CD34-positive Enriched Peripheral Blood Stem Cells", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4033155", "l": "jugular ganglion CGRP neuron", "d": ["A sensory neuron that has the soma located in the jugular ganglion and expresses the marker calcitonin gene-related peptide (CGRP)."], "t": []}], "preferred_name": "jugular ganglion CGRP neuron", "taxa": []}
{"type": "biolink:Cell", "ic": 84.83823963392128, "identifiers": [{"i": "UMLS:C0333735", "l": "Gemistocyte", "d": [], "t": []}, {"i": "NCIT:C37132", "l": "Gemistocytic Neoplastic Astrocyte", "d": ["A pathologic astrocyte in which the cell body swells and contains glial filaments and an eccentric nucleus; seen particularly in demyelinating and neoplastic conditions."], "t": []}, {"i": "SNOMEDCT:55319008", "l": "", "d": [], "t": []}], "preferred_name": "Gemistocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0000384", "l": "ligament cell", "d": [], "t": []}], "preferred_name": "ligament cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5886247", "l": "Cells.chromosome Y deletion", "d": [], "t": []}], "preferred_name": "Cells.chromosome Y deletion", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C4687465", "l": "Allogeneic CD123-specific Universal CAR123-expressing T-lymphocytes", "d": [], "t": []}, {"i": "NCIT:C146806", "l": "Allogeneic CD123-specific Universal CAR123-expressing T-lymphocytes", "d": ["Allogeneic, off-the-shelf, universal transcription activator-like effector nuclease (TALEN)-engineered T-lymphocytes that have been genetically modified to express a chimeric antigen receptor (CAR) targeting the tumor-associated antigen (TAA) human interleukin-3 receptor alpha chain (IL3RA; cluster of differentiation 123; CD123), with potential immunomodulating and antineoplastic activities.  Upon transfusion of allogeneic CD123-specific universal CAR123-expressing T-lymphocytes (UCART123), these cells target and bind to cancer cells expressing CD123. This induces selective toxicity in and causes lysis of CD123-expressing tumor cells. CD123 is normally expressed on committed blood progenitor cells in the bone marrow; its overexpression is associated with both increased leukemic cell proliferation and aggressiveness. Using TALEN technology, the UCART123 cells no longer express the endogenous T-cell receptor (TCR) thereby abrogating the potential induction of graft-versus-host disease (GvHD) by the donor T-cells."], "t": []}], "preferred_name": "Allogeneic CD123-specific Universal CAR123-expressing T-lymphocytes", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0000780", "l": "multinuclear odontoclast", "d": ["A specialized multinuclear osteoclast associated with the absorption and removal of cementum."], "t": []}], "preferred_name": "multinuclear odontoclast", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5181363", "l": "Spermatozoa Motile | Semen | Fertility testing", "d": [], "t": []}], "preferred_name": "Spermatozoa Motile | Semen | Fertility testing", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4684850", "l": "Autologous Anti-CD19/CD22 CAR-T Cells", "d": [], "t": []}], "preferred_name": "Autologous Anti-CD19/CD22 CAR-T Cells", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C2326142", "l": "Keratinized squamous cell", "d": [], "t": []}], "preferred_name": "Keratinized squamous cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4530304", "l": "Yescarta", "d": [], "t": []}], "preferred_name": "Yescarta", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C2328956", "l": "Set of cholinergic cells of dorsal tegmental area [Ch5]", "d": [], "t": []}], "preferred_name": "Set of cholinergic cells of dorsal tegmental area [Ch5]", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5166478", "l": "Helmet cells | Blood | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Helmet cells | Blood | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C3495561", "l": "A7 noradrenaline cells", "d": [], "t": []}], "preferred_name": "A7 noradrenaline cells", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0009012", "l": "transit amplifying cell of small intestine", "d": ["A rapidly proliferating population of cells that differentiate from stem cells of the intestinal crypt of the small intestine. Stem cells located in the crypts of Lieberkühn give rise to proliferating progenitor or transit amplifying cells that differentiate into the four major epithelial cell types. These include columnar absorptive cells or enterocytes, mucous secreting goblet cells, enteroendocrine cells and paneth cells."], "t": []}], "preferred_name": "transit amplifying cell of small intestine", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5177473", "l": "Plasma cells/100 leukocytes | Dialysis fluid | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Plasma cells/100 leukocytes | Dialysis fluid | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "CL:0002469", "l": "MHC-II-negative classical monocyte", "d": ["Gr1-high monocyte that lacks MHC-II receptor complex."], "t": []}], "preferred_name": "MHC-II-negative classical monocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5783615", "l": "C7R-expressing EBVSTs", "d": [], "t": []}, {"i": "NCIT:C190298", "l": "C7R-expressing EBVSTs", "d": ["A preparation of human Epstein-Barr virus (EBV)-specific T-lymphocytes (EBVSTs) that have been genetically modified to express the constitutively active interleukin 7 (IL-7) receptor (C7R; IL-7R), with potential immunostimulating and antineoplastic activities. Upon administration, the CR7-expressing EBVSTs specifically recognize and bind EBV-infected tumor cells, resulting in tumor cell lysis. EBV, a ubiquitous human herpes virus, is associated with various malignancies, specifically nasopharyngeal carcinoma and lymphomas, including Hodgkin and non-Hodgkin. C7R triggers IL-7-mediated signaling that promotes T-cell proliferation and survival. The enhanced T-cell survival prolongs EBV-infected tumor cell killing and anti-tumor activity."], "t": []}], "preferred_name": "C7R-expressing EBVSTs", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5157376", "l": "CD2+CD7+ cells | Blood | Cell markers", "d": [], "t": []}], "preferred_name": "CD2+CD7+ cells | Blood | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": 78.54651317367835, "identifiers": [{"i": "CL:0005024", "l": "somatomotor neuron", "d": ["A motor neuron that innervates a skeletal muscle.  These motor neurons are all excitatory and cholinergic."], "t": []}], "preferred_name": "somatomotor neuron", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4253020", "l": "Set of type B cells of pancreatic islet", "d": [], "t": []}], "preferred_name": "Set of type B cells of pancreatic islet", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5157354", "l": "CD19+CD27+IgD-IgM- cells | Blood | Cell markers", "d": [], "t": []}], "preferred_name": "CD19+CD27+IgD-IgM- cells | Blood | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": 87.18682603146104, "identifiers": [{"i": "CL:4023044", "l": "non-medulla, extratelencephalic-projecting glutamatergic neuron of the primary motor cortex", "d": ["An extratelencephalic-projecting glutamatergic neuron located in layer 5b of the primary motor cortex that does not project to the medulla. Non-MY ET cells are large, big-tufted cells with the apical dendrite often bifurcating close to the soma, suggesting they are corticospinal cells. Non-MY ET cells have bigger hyperpolarization sag, lower input resistance, and smaller AP width, compared to L5 IT neurons."], "t": []}], "preferred_name": "non-medulla, extratelencephalic-projecting glutamatergic neuron of the primary motor cortex", "taxa": []}
{"type": "biolink:Cell", "ic": 84.21065366064373, "identifiers": [{"i": "CL:0008047", "l": "intrafusal muscle fiber", "d": ["A skeletal muscle fiber that is part of a muscle spindle. These are specialized muscle fibers that serve as proprioceptors, detecting the amount and rate of change in length of a muscle. They are innervated by both sensory neurons and motor neurons (gamma and beta motorneurons, collectively referred to as fusimotor neurons)."], "t": []}], "preferred_name": "intrafusal muscle fiber", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5185785", "l": "ZAP70 cells | Blood | Cell markers", "d": [], "t": []}], "preferred_name": "ZAP70 cells | Blood | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5154297", "l": "Band form neutrophils | Blood | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Band form neutrophils | Blood | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1267951", "l": "Lymphocyte positive for CD59 antigen", "d": [], "t": []}, {"i": "SNOMEDCT:117392001", "l": "", "d": [], "t": []}], "preferred_name": "Lymphocyte positive for CD59 antigen", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4307037", "l": "Astro-NT NN_2 Gm30524 astrocyte (Mmus)", "d": ["A astrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Aqp4 (Mmus), A330076C08Rik (Mmus), Fbln5 (Mmus), Mdga2 (Mmus). It is distinguished from other Astro-NT NN_2 cells by expression of Gm30524. These cells are located in the Medulla, Cerebellum, brain , in or close to the regions: Ventral cochlear nucleus, arbor vitae . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5217 Astro-NT NN_2."], "t": []}], "preferred_name": "Astro-NT NN_2 Gm30524 astrocyte (Mmus)", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1440327", "l": "Cell negative for CD2 antigen and positive for CD5 antigen", "d": [], "t": []}, {"i": "SNOMEDCT:1373187002", "l": "", "d": [], "t": []}], "preferred_name": "Cell negative for CD2 antigen and positive for CD5 antigen", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1514078", "l": "Neoplastic Round Cell with Neuronal Differentiation", "d": [], "t": []}, {"i": "NCIT:C37101", "l": "Neoplastic Round Cell with Neuronal Differentiation", "d": [], "t": []}], "preferred_name": "Neoplastic Round Cell with Neuronal Differentiation", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0020033", "l": "stem cell memory CD4-positive, alpha-beta T cell", "d": ["A CD4-positive memory alpha-beta T cell with stem-like properties that is long-lived, retains a naïve-like phenotype, and exhibits self-renewal and multipotent differentiation capacity. This cell acts as a stem-like reservoir capable of regenerating central and effector memory T cell subsets."], "t": []}], "preferred_name": "stem cell memory CD4-positive, alpha-beta T cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5177458", "l": "Plasma cells immature | Bone marrow | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Plasma cells immature | Bone marrow | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C4086002", "l": "Autologous CD19CAR-CD28-CD3zeta-EGFRt-expressing Tn/mem-enriched T-lymphocytes", "d": [], "t": []}, {"i": "NCIT:C124795", "l": "Autologous CD19CAR-CD28-CD3zeta-EGFRt-expressing Tn/mem-enriched T-lymphocytes", "d": ["A preparation of genetically modified autologous lymphocytes comprised of CD62L-positive naïve and memory T-cells (Tn/mem), that are transduced ex vivo with a self-inactivating (SIN) lentiviral vector expressing a hinge-optimized chimeric antigen receptor (CAR) specific for the CD19 antigen and containing CD28 and CD3 zeta signaling domains, and a truncated form of the human epidermal growth factor receptor (EGFRt), with potential immunostimulating and antineoplastic activities. Upon isolation of peripheral blood lymphocytes (PBLs), transduction of the CD62L-positive T-lymphocytes, expansion ex vivo and reintroduction of the cells into the patient, the autologous CD19R(EQ)-CD28-CD3zeta-EGFRt-expressing Tn/mem-enriched T-cells target CD19-expressing tumor cells, thereby inducing selective toxicity in CD19-expressing tumor cells. CD19 antigen is a B-cell specific cell surface antigen expressed in all B-cell lineage malignancies.  Devoid of both ligand binding domains and tyrosine kinase activity, EGFRt both facilitates in vivo detection of the administered T-cells and can promote elimination of those cells upon a cetuximab-induced antibody dependent cellular cytotoxicity response. Tn/mem T-cells include naïve T-cells, central memory T-cells (Tcm) and stem cell memory T-cells (Tscm). CD19R(EQ) contains two point mutations in the immunoglobulin (Ig) G4 spacer region, thereby preventing recognition of the CAR by Fc receptors (FcRs)."], "t": []}], "preferred_name": "Autologous CD19CAR-CD28-CD3zeta-EGFRt-expressing Tn/mem-enriched T-lymphocytes", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4038491", "l": "Cells.diploid.G2 phase", "d": [], "t": []}], "preferred_name": "Cells.diploid.G2 phase", "taxa": []}
{"type": "biolink:Cell", "ic": 85.53200374075534, "identifiers": [{"i": "CL:1001036", "l": "vasa recta cell", "d": ["A cell that is part of a vasa recta."], "t": []}], "preferred_name": "vasa recta cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5184820", "l": "Variant lymphocytes | Cerebral spinal fluid | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Variant lymphocytes | Cerebral spinal fluid | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": 90.871710685482, "identifiers": [{"i": "CL:2000086", "l": "neocortex basket cell", "d": ["Any basket cell that is part of a neocortex."], "t": []}], "preferred_name": "neocortex basket cell", "taxa": []}
{"type": "biolink:Cell", "ic": 65.27904399249529, "identifiers": [{"i": "CL:0000827", "l": "pro-T cell", "d": ["A lymphoid progenitor cell of the T cell lineage, with some lineage specific marker expression, but not yet fully committed to the T cell lineage."], "t": []}], "preferred_name": "pro-T cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5157513", "l": "CD38+CD138+ cells | Blood | Cell markers", "d": [], "t": []}], "preferred_name": "CD38+CD138+ cells | Blood | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": 90.871710685482, "identifiers": [{"i": "UMLS:C1518308", "l": "Neutrophil with Pseudo Chediak-Higashi Granules", "d": [], "t": []}, {"i": "NCIT:C37175", "l": "Neutrophil with Pseudo Chediak-Higashi Granules", "d": [], "t": []}], "preferred_name": "Neutrophil with Pseudo Chediak-Higashi Granules", "taxa": []}
{"type": "biolink:Cell", "ic": 63.48684274192801, "identifiers": [{"i": "UMLS:C0016030", "l": "Fibroblasts", "d": [], "t": []}, {"i": "NCIT:C12482", "l": "Fibroblast", "d": [], "t": []}, {"i": "MESH:D005347", "l": "Fibroblasts", "d": [], "t": []}, {"i": "SNOMEDCT:52547004", "l": "", "d": [], "t": []}], "preferred_name": "Fibroblasts", "taxa": []}
{"type": "biolink:Cell", "ic": 89.40238429118027, "identifiers": [{"i": "UMLS:C1709208", "l": "Neoplastic Thyroid Gland Follicular Clear Cell", "d": [], "t": []}, {"i": "NCIT:C47832", "l": "Neoplastic Thyroid Gland Follicular Clear Cell", "d": [], "t": []}], "preferred_name": "Neoplastic Thyroid Gland Follicular Clear Cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1267823", "l": "T lymphocyte positive for both CD4 antigen and CD29 antigen", "d": [], "t": []}, {"i": "SNOMEDCT:115401003", "l": "", "d": [], "t": []}], "preferred_name": "T lymphocyte positive for both CD4 antigen and CD29 antigen", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5163715", "l": "Erythrocytes | Dialysis fluid peritoneal | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Erythrocytes | Dialysis fluid peritoneal | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1507170", "l": "CD3+CD62L+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:1373014000", "l": "", "d": [], "t": []}], "preferred_name": "CD3+CD62L+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "UMLS:C1708872", "l": "Malignant Epithelial Cell with Ground Glass Cytoplasm", "d": [], "t": []}, {"i": "NCIT:C54589", "l": "Malignant Epithelial Cell with Ground Glass Cytoplasm", "d": [], "t": []}], "preferred_name": "Malignant Epithelial Cell with Ground Glass Cytoplasm", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5554942", "l": "Autologous PD-1 Nanobody-expressing Anti-MSLN CAR T-cells", "d": [], "t": []}, {"i": "NCIT:C178316", "l": "Autologous PD-1 Nanobody-expressing Anti-MSLN CAR T-cells", "d": ["A preparation of autologous T-lymphocytes that have been genetically modified to express a nanobody that targets the negative immunoregulatory human cell surface receptor programmed cell death protein 1 (PD-1; PDCD1; CD279) and transduced with a gene encoding a chimeric antigen receptor (CAR) specific for the human tumor-associated antigen (TAA) mesothelin (MSLN), with potential immunomodulating and antineoplastic activities. After isolation, transduction, expansion in culture, and reintroduction into the patient, the autologous PD-1 nanobody-expressing anti-MSLN CAR T-cells specifically target and kill MSLN-expressing tumor cells. The anti-PD-1 expressed on the CAR T-cells binds to PD-1 expressed on T-cells and prevents the interaction of PD-1 with its ligand programmed cell death 1 ligand 1 (PD-L1, PD-1L1; CD274) expressed on tumor cells. This prevents PD-1-mediated signaling and T-cell exhaustion, enhances T-cell activation, and results in enhanced toxicity in MSLN-expressing tumor cells. PD-1, an immunoglobulin (Ig) superfamily transmembrane protein and inhibitory receptor, negatively regulates T-cell activation and overexpression within the tumor microenvironment (TME) and inhibits T-cell function. MSLN, a cell surface glycoprotein involved in cell adhesion, is overexpressed in a variety of cancer cell types."], "t": []}], "preferred_name": "Autologous PD-1 Nanobody-expressing Anti-MSLN CAR T-cells", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4080738", "l": "human cord blood hematopoietic progenitor cell 500000000 in 25 mL INTRAVENOUS INJECTION, SUSPENSION [CORDCYTE]", "d": [], "t": []}], "preferred_name": "human cord blood hematopoietic progenitor cell 500000000 in 25 mL INTRAVENOUS INJECTION, SUSPENSION [CORDCYTE]", "taxa": []}
{"type": "biolink:Cell", "ic": 80.96785908349635, "identifiers": [{"i": "CL:4300359", "l": "astrocyte of cerebrum (Mmus)", "d": ["A transcritpomically defined type of astrocytes primarily restricted to the dorsal regions of the cerebrum. It is distinguished from other cells in the brain by selective expression of Gja1 (Mmus), Lhx2 (Mmus), Gpc5 (Mmus), Nr2f1 (Mmus). Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Subclass:319 Astro-TE NN."], "t": []}], "preferred_name": "astrocyte of cerebrum (Mmus)", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5157329", "l": "CD16+CD57- | White blood cells | Cell markers", "d": [], "t": []}], "preferred_name": "CD16+CD57- | White blood cells | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5853758", "l": "OSSM-001", "d": [], "t": []}], "preferred_name": "OSSM-001", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4033165", "l": "myenteric ganglion of small intestine ChAT/CALR/SOM/SP neuron", "d": ["An enteric neuron that has the soma located in the myenteric ganglion of the small intestine and expresses the marker choline acetyltransferase (ChAT), calretinin (CALR), somatostatin (SOM), and substance P (SP)."], "t": []}], "preferred_name": "myenteric ganglion of small intestine ChAT/CALR/SOM/SP neuron", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0007021", "l": "alarm substance cell", "d": ["Secretory cell that produces a chemical mixture that triggers antipredator behavior. The substance is released only upon disruption of the epidermis. [Behavior of teleost fishes, second edition, edited by Pitcher, 1992]"], "t": []}], "preferred_name": "alarm substance cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4518168", "l": "Population of all immature basophils in portion of fluid", "d": [], "t": []}, {"i": "SNOMEDCT:725439004", "l": "", "d": [], "t": []}], "preferred_name": "Population of all immature basophils in portion of fluid", "taxa": []}
{"type": "biolink:Cell", "ic": 52.29445898610551, "identifiers": [{"i": "UMLS:C1513929", "l": "Neoplastic B-Lymphocyte", "d": [], "t": []}, {"i": "NCIT:C38640", "l": "Neoplastic B-Lymphocyte", "d": [], "t": []}], "preferred_name": "Neoplastic B-Lymphocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0009069", "l": "CD8aa(II) thymocyte", "d": ["An unconventional T lymphocyte population within the thymic medulla that expresses both alpha/beta and gamma/delta T cell signatures."], "t": []}], "preferred_name": "CD8aa(II) thymocyte", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C6065687", "l": "E-CEL UVEC cells", "d": [], "t": []}], "preferred_name": "E-CEL UVEC cells", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "CL:0002214", "l": "type IIa muscle cell", "d": ["A type II muscle cell that contains large amounts of myoglobin, has many mitochondria and very many blood capillaries. Type II A cells are red, have a very high capacity for generating ATP by oxidative metabolic processes, split ATP at a very rapid rate, have a fast contraction velocity and are resistant to fatigue."], "t": []}, {"i": "UMLS:C2336252", "l": "Type 2A muscle fiber", "d": [], "t": []}], "preferred_name": "type IIa muscle cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5706428", "l": "Autologous Tumor Infiltrating Lymphocytes LM103", "d": [], "t": []}, {"i": "NCIT:C187659", "l": "Autologous Tumor Infiltrating Lymphocytes LM103", "d": ["A preparation of autologous tumor infiltrating lymphocytes (TILs) derived from each patient's resected tumor and expanded ex vivo, with potential immunomodulating and antineoplastic activities. Upon administration back into the patient, the autologous TILs LM103 specifically recognize and kill the patient's tumor cells."], "t": []}], "preferred_name": "Autologous Tumor Infiltrating Lymphocytes LM103", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0369602", "l": "Leukocytes other", "d": [], "t": []}], "preferred_name": "Leukocytes other", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4038446", "l": "Reticulocytes.hypochromic", "d": [], "t": []}], "preferred_name": "Reticulocytes.hypochromic", "taxa": []}
{"type": "biolink:Cell", "ic": 90.871710685482, "identifiers": [{"i": "CL:0008012", "l": "quiescent skeletal muscle satellite cell", "d": ["A skeletal muscle satellite cell that is mitotically quiescent.  These cells are wedge shaped and have a large nuclear to cytoplasmic ratio with few organelles, a small nucleus and condensed interphase chromatin. Satellite cells typically remain in this state until activated following muscle damage."], "t": []}], "preferred_name": "quiescent skeletal muscle satellite cell", "taxa": []}
{"type": "biolink:Cell", "ic": 90.871710685482, "identifiers": [{"i": "CL:4023123", "l": "hypothalamus kisspeptin neuron", "d": ["A kisspeptin neuron that is located in the hypothalamus. These neurons project to and activate gonadotrophin-releasing hormone neurons (acting via the kisspeptin receptor) in the hypothalamus and stimulate the secretion of gonadotrophin-releasing hormone."], "t": []}], "preferred_name": "hypothalamus kisspeptin neuron", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:2000041", "l": "dermis microvascular lymphatic vessel endothelial cell", "d": ["Any dermis lymphatic vessel endothelial cell that is part of a microvascular endothelium."], "t": []}], "preferred_name": "dermis microvascular lymphatic vessel endothelial cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5855516", "l": "Autologous Anti-CD19 DASH CAR-T Cells", "d": [], "t": []}, {"i": "NCIT:C199282", "l": "Autologous Anti-CD19 DASH CAR-T Cells", "d": ["A preparation of autologous T-lymphocytes that have been genetically modified and transduced with a gamma-retrovirus vector expressing a second-generation chimeric antigen receptor (CAR) targeting the tumor-associated antigen (TAA) CD19, with potential immunostimulating and antineoplastic activities. Upon administration, autologous anti-CD19 DASH CAR-T cells target and bind to CD19-expressing tumor cells, thereby inducing selective toxicity in CD19-expressing tumor cells. CD19 antigen is a B-cell specific cell surface antigen expressed in B-cell lineage malignancies."], "t": []}], "preferred_name": "Autologous Anti-CD19 DASH CAR-T Cells", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C4727097", "l": "Autologous TCR-engineered T-cells IMA202", "d": [], "t": []}, {"i": "NCIT:C153218", "l": "Autologous TCR-engineered T-cells IMA202", "d": ["A preparation of autologous T-lymphocytes that are genetically modified with a lentiviral vector encoding a T-cell receptor (TCR) targeting patient-specific tumor associated antigens (TAAs), with potential antineoplastic activity. Upon intravenous administration back into the patient, the autologous TCR-engineered T-cells IMA202 specifically recognize and bind to the TAA on cancer cells, which induces a cytotoxic T-lymphocyte (CTL)-mediated immune response against the TAA-positive cancer cells."], "t": []}], "preferred_name": "Autologous TCR-engineered T-cells IMA202", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1267980", "l": "Lymphocyte positive for CD93 antigen", "d": [], "t": []}, {"i": "SNOMEDCT:117420002", "l": "", "d": [], "t": []}], "preferred_name": "Lymphocyte positive for CD93 antigen", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0682542", "l": "ciliated cell", "d": [], "t": []}], "preferred_name": "ciliated cell", "taxa": []}
{"type": "biolink:Cell", "ic": 82.16838616155795, "identifiers": [{"i": "CL:0002209", "l": "intermediate epitheliocyte", "d": ["An epithelial cell present in the trachea and bronchi; columnar in shape; generally lack cilia; immature forms of ciliated or secretory cells which have been formed from stem cells."], "t": []}, {"i": "UMLS:C1181286", "l": "Intermediate epitheliocyte", "d": [], "t": []}], "preferred_name": "intermediate epitheliocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4033067", "l": "mural granulosa cell", "d": ["A follicular cell of ovary that differentiates from a cuboidal granulosa cell during the secondary follicle stage. Mural granulosa cells line the inner surface of the follicle wall, surrounding the fluid-filled antral cavity. These cells produce oestrogen during the follicular phase in response to follicle-stimulating hormone (FSH), and progesterone after ovulation in response to luteinizing hormone (LH)."], "t": []}], "preferred_name": "mural granulosa cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4307090", "l": "OPC NN_1 Rmi2 oligodendrocyte precursor cell (Mmus)", "d": ["A oligodendrocyte precursor cell of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Pdgfra (Mmus), Olig1 (Mmus), Rmi2 (Mmus), Col27a1 (Mmus). It is distinguished from other OPC NN_1 cells by expression of Rmi2, Col27a1. These cells are located in the Hypothalamus, Midbrain, Pallidum, brain . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5270 OPC NN_1."], "t": []}], "preferred_name": "OPC NN_1 Rmi2 oligodendrocyte precursor cell (Mmus)", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4307027", "l": "cerebellar astrocyte (Mmus)", "d": ["A transcriptomically defined type of astrocyte localized exclusively in the cerebellum beneath the Purkinje cell layer. It is distinguished from other cells in the brain by selective expression of Dao (Mmus), Efemp1 (Mmus). Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5207 Astro-CB NN_1."], "t": []}], "preferred_name": "cerebellar astrocyte (Mmus)", "taxa": []}
{"type": "biolink:Cell", "ic": 89.40238429118027, "identifiers": [{"i": "CL:0001054", "l": "CD14-positive monocyte", "d": ["A monocyte that expresses CD14 and is negative for the lineage markers CD3, CD19, and CD20."], "t": []}], "preferred_name": "CD14-positive monocyte", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1440337", "l": "CD62 Cells", "d": [], "t": []}, {"i": "SNOMEDCT:1372914007", "l": "", "d": [], "t": []}], "preferred_name": "CD62 Cells", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5163550", "l": "Epithelial cells.non-squamous | Urine sediment | Urinalysis", "d": [], "t": []}], "preferred_name": "Epithelial cells.non-squamous | Urine sediment | Urinalysis", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5238364", "l": "Partially Engineered T-regulatory Cell Donor Graft TRGFT-201", "d": [], "t": []}], "preferred_name": "Partially Engineered T-regulatory Cell Donor Graft TRGFT-201", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5854546", "l": "TCR-engineered T-cells HRYZ-T101", "d": [], "t": []}, {"i": "NCIT:C200468", "l": "TCR-engineered T-cells HRYZ-T101", "d": ["A preparation of genetically engineered T-lymphocytes expressing a T-cell receptor (TCR) targeting a specific tumor-associated antigen (TAA) of the human papillomavirus (HPV) type 18 (HPV-18), with potential antineoplastic activity. Upon administration, HPV-18 expressing TCR T-cells target and bind to tumor cells expressing the HPV-18 TAA leading to selective cytotoxicity in HPV-18 TAA-expressing tumor cells. HPV18 TAAs are overexpressed in a variety of tumor cell types."], "t": []}], "preferred_name": "TCR-engineered T-cells HRYZ-T101", "taxa": []}
{"type": "biolink:Cell", "ic": 79.07356789860069, "identifiers": [{"i": "UMLS:C0229571", "l": "Type I cell of carotid body", "d": [], "t": []}, {"i": "NCIT:C36965", "l": "Glomus Cell", "d": [], "t": []}, {"i": "SNOMEDCT:75737006", "l": "", "d": [], "t": []}], "preferred_name": "Type I cell of carotid body", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0001043", "l": "activated CD4-positive, alpha-beta T cell, human", "d": ["A recently activated CD4-positive, alpha-beta T cell with the phenotype HLA-DRA-positive, CD38-positive, CD69-positive, CD62L-negative, CD127-negative, and CD25-positive."], "t": []}], "preferred_name": "activated CD4-positive, alpha-beta T cell, human", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4042036", "l": "melanin-concentrating hormone neuron", "d": ["A neuron of the central nervous system with its soma primarily located in the lateral hypothalamic area and surrounding regions, including the zona incerta. This neuron type expresses melanin-concentrating hormone and is involved in regulating various physiological processes, including sleep, feeding behavior, and energy homeostasis."], "t": []}], "preferred_name": "melanin-concentrating hormone neuron", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C4055480", "l": "Allogeneic BKV-specific Cytotoxic T-lymphocytes", "d": [], "t": []}, {"i": "NCIT:C123277", "l": "Allogeneic BKV-specific Cytotoxic T-lymphocytes", "d": ["Allogeneic cytotoxic T-lymphocytes (CTLs) that are specifically reactive to BK virus (BKV), with potential antiviral activity. Upon infusion of allogeneic BK-specific CTLs into immunocompromised patients who were infected with BKV after allogeneic stem cell transplantation, these cells exert a specific CTL response against BKV, thereby killing and eliminating the BKV-infected cells. BKV is a member of the polyomavirus family that may cause mild symptoms in normal, healthy people; however, BKV infection can lead to severe disease in immunocompromised patients."], "t": []}], "preferred_name": "Allogeneic BKV-specific Cytotoxic T-lymphocytes", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1440302", "l": "CD38+CD56+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:1373024008", "l": "", "d": [], "t": []}], "preferred_name": "CD38+CD56+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0000973", "l": "IgA memory B cell", "d": ["A class switched memory B cell that expresses IgA."], "t": []}], "preferred_name": "IgA memory B cell", "taxa": []}
{"type": "biolink:Cell", "ic": 92.76600187037766, "identifiers": [{"i": "CL:0000691", "l": "stellate interneuron", "d": ["Any interneuron that has characteristic some stellate morphology."], "t": []}], "preferred_name": "stellate interneuron", "taxa": []}
{"type": "biolink:Cell", "ic": 85.53200374075534, "identifiers": [{"i": "CL:0000443", "l": "calcitonin secreting cell", "d": ["Any secretory cell that is capable of some calcitonin secretion."], "t": []}], "preferred_name": "calcitonin secreting cell", "taxa": []}
{"type": "biolink:Cell", "ic": 90.871710685482, "identifiers": [{"i": "CL:0001040", "l": "non-terminally differentiated osteoblast", "d": ["Osteoblast that is non-terminally differentiated and located in cellular bone tissue or under the periosteum in acellular bone."], "t": []}], "preferred_name": "non-terminally differentiated osteoblast", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C3899843", "l": "C46/CCR5/P140K Lentiviral Vector-transduced Autologous HSPCs", "d": [], "t": []}, {"i": "NCIT:C119735", "l": "C46/CCR5/P140K Lentiviral Vector-transduced Autologous HSPCs", "d": ["Autologous CD34-positive, hematopoietic stem progenitor cells (HSPCs) genetically modified with a lentiviral vector expressing short hairpin RNA that targets human chemokine receptor 5 (CCR5) mRNA (shCCR5), the HIV entry inhibitor C46, a membrane-anchored 46-amino acid sequence found in HIV-1 gp41, and the drug resistance gene P140K, a mutant form of the DNA repair protein O6-methylguanine-DNA methyltransferase (MGMT), used to potentially provide resistance against human immunodeficiency virus (HIV) infection. Human autologous CD34+ HSPCs are isolated and transduced ex vivo with the pRSC-H1.shCCR5.Ubic.C46.EF1alpha.P140K.wpre lentiviral vector. shCCR5 binds to CCR5 mRNA and inhibits the expression of CCR5, a HIV-1 co-receptor that mediates HIV attachment and cell entry. Additionally, the expression of C46 blocks HIV-1 fusion to the cellular membrane. Upon re-infusion into the HIV-infected lymphoma patient, the C46/shCCR5/P140K lentiviral vector-transduced autologous HSPCs are resistant to HIV entry, which protects these cells against HIV infection and replication, and increases the amount of HIV-resistant CD4+ T-cells. HIV-resistant HSPCs could provide long-term protection against latent HIV infection and against HIV-associated cancers. In addition, the formation of immune cells resistant to HIV may result in the destruction of HIV-infected cells. P140K expression facilitates the in vivo chemoselection of gene-modified HSPCs, using O6-benzylguanine (O6BG)/bis-chloroethylnitrosourea (BCNU/carmustine), which increases the proportion of these HIV resistant CD34+ cells. P140K also protects these stem cells from future destruction by certain chemotherapeutic agents; if cancer were to develop, P140K is not inactivated by the MGMT inhibitor O6BG."], "t": []}], "preferred_name": "C46/CCR5/P140K Lentiviral Vector-transduced Autologous HSPCs", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5157511", "l": "CD38 cells | Blood | Cell markers", "d": [], "t": []}], "preferred_name": "CD38 cells | Blood | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0002207", "l": "brush cell of trachea", "d": ["Brush cell of the epithelium in the trachea."], "t": []}, {"i": "UMLS:C2334994", "l": "Brush cell of epithelium of trachea", "d": [], "t": []}], "preferred_name": "brush cell of trachea", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5157548", "l": "CD4+CD45RA+CD45RB+CD45RC+ cells | Tissue and Smears | Cell markers", "d": [], "t": []}], "preferred_name": "CD4+CD45RA+CD45RB+CD45RC+ cells | Tissue and Smears | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1516092", "l": "Atypical Endothelial Cell", "d": [], "t": []}, {"i": "NCIT:C37087", "l": "Atypical Endothelial Cell", "d": [], "t": []}], "preferred_name": "Atypical Endothelial Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 81.743421370964, "identifiers": [{"i": "CL:0002074", "l": "myocardial endocrine cell", "d": ["The myoendocrine cellis a specialized myocyte localized mainly in the right and left atrial appendages, and also scattered within other areas of the atria and along the conductive system in the ventricular septum. The most conspicuous feature distinguishing myoendocrine cells from other atrial myoctyes is the presence of membane-bounded secretory granules (these granules contain precursor of cardiodilatins or atrial natriuretic polypeptides)."], "t": []}, {"i": "UMLS:C1179876", "l": "Myocardial endocrine cell", "d": [], "t": []}], "preferred_name": "myocardial endocrine cell", "taxa": []}
{"type": "biolink:Cell", "ic": 90.871710685482, "identifiers": [{"i": "UMLS:C1514041", "l": "Neoplastic Myoid Cell", "d": [], "t": []}, {"i": "NCIT:C36964", "l": "Neoplastic Myoid Cell", "d": ["A neoplastic spindle-shaped cell with cytological and immunohistochemical features of a muscle cell."], "t": []}], "preferred_name": "Neoplastic Myoid Cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5216253", "l": "Lymphocytes|NCnc|Pt|Periton fld", "d": [], "t": []}], "preferred_name": "Lymphocytes|NCnc|Pt|Periton fld", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "CL:0001039", "l": "terminally differentiated osteoblast", "d": ["Osteoblast that is terminally differentiated, located adjacent to acellular or cellular bone tissue within periosteum, and is capable of mineralizing the matrix."], "t": []}], "preferred_name": "terminally differentiated osteoblast", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "UMLS:C2986568", "l": "Neoplastic Eosinophilic Spindle Cell", "d": [], "t": []}, {"i": "NCIT:C94551", "l": "Neoplastic Eosinophilic Spindle Cell", "d": ["A spindle-shaped neoplastic cell with eosinophilic and granular, often abundant cytoplasm."], "t": []}], "preferred_name": "Neoplastic Eosinophilic Spindle Cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4722589", "l": "KTE-C19", "d": [], "t": []}], "preferred_name": "KTE-C19", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C6063340", "l": "Cell negative for CD3 antigen and positive for CD56 antigen", "d": [], "t": []}, {"i": "SNOMEDCT:1373180000", "l": "", "d": [], "t": []}], "preferred_name": "Cell negative for CD3 antigen and positive for CD56 antigen", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4023119", "l": "displaced amacrine cell", "d": ["A subpopulation of amacrine cell that migrate further than other amacrine cells, and come to lie basal to the inner plexiform layer (IPL) in the ganglion cell layer. Displaced amacrine cells still have their neurites extending apically into the IPL, and therefore exhibit an inverted polarity with respect to the other amacrine cells."], "t": []}], "preferred_name": "displaced amacrine cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4267789", "l": "Cells.CD27+IgD-", "d": [], "t": []}], "preferred_name": "Cells.CD27+IgD-", "taxa": []}
{"type": "biolink:Cell", "ic": 73.15076615569336, "identifiers": [{"i": "UMLS:C1709185", "l": "Neoplastic Mature Adipocyte", "d": [], "t": []}, {"i": "NCIT:C48897", "l": "Neoplastic Mature Adipocyte", "d": [], "t": []}], "preferred_name": "Neoplastic Mature Adipocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1511468", "l": "CY82", "d": [], "t": []}, {"i": "NCIT:C20242", "l": "CY82", "d": ["Provider: CyThera, Inc., San Diego, CA. No information from provider. This cell line meets the criteria for the use of human embryonic stem cells by federally funded researchers."], "t": []}], "preferred_name": "CY82", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0599819", "l": "PBL (peripheral blood lymphocyte)", "d": [], "t": []}], "preferred_name": "PBL (peripheral blood lymphocyte)", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5179962", "l": "Round cells | Semen | Fertility testing", "d": [], "t": []}], "preferred_name": "Round cells | Semen | Fertility testing", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "CL:2000075", "l": "anterior visceral endoderm cell", "d": ["Any endodermal cell that is part of a anterior visceral endoderm."], "t": []}], "preferred_name": "anterior visceral endoderm cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4052004", "l": "intestinal fibroblastic reticular cell", "d": ["A specialized fibroblastic reticular cell that is part of gut-associated lymphoid tissue (GALT), responsible for forming a structural network that facilitates immune cell interactions. This cell is found in Peyer's patches, cryptopatches, and isolated lymphoid follicles. It plays crucial roles in maintaining intestinal immunity by controlling innate lymphoid cell homeostasis and function, organizing lymphoid structures, and contributing to intestinal microbiome balance."], "t": []}], "preferred_name": "intestinal fibroblastic reticular cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0004217", "l": "H1 horizontal cell", "d": ["A horizontal cell with a large cell body, thick dendrites, and a large dendritic arbor."], "t": []}, {"i": "UMLS:C2329330", "l": "H I cell of retina", "d": [], "t": []}], "preferred_name": "H1 horizontal cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5163683", "l": "Erythrocyte clumps | Urine sediment | Urinalysis", "d": [], "t": []}], "preferred_name": "Erythrocyte clumps | Urine sediment | Urinalysis", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C0225668", "l": "Clara cell", "d": [], "t": []}, {"i": "NCIT:C13143", "l": "Club Cell", "d": ["A rounded, club-shaped, nonciliated cell found in between ciliated cells in the epithelium of respiratory and terminal bronchioles. It has a secretory function."], "t": []}, {"i": "SNOMEDCT:77810002", "l": "", "d": [], "t": []}], "preferred_name": "Clara cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5556547", "l": "ECT204", "d": [], "t": []}, {"i": "NCIT:C180673", "l": "ECT204 Transgene-transduced Autologous T Cells ECT204", "d": ["A preparation of autologous human T-lymphocytes transduced with a lentiviral vector expressing the ECT204 transgene that encodes an antibody-based antigen-binding domain targeting the tumor-associated antigen (TAA) glypican-3 (GPC3) and an effector-binding domain, with potential immunomodulating and antineoplastic activities. Following leukapheresis, isolation of lymphocytes, expansion ex vivo, transduction, and re-introduction into the patient, the ECT204 transgene-transduced autologous T cells ECT204 target and bind to tumor cells expressing GPC3. This results in cytotoxic T-lymphocyte (CTL)-mediated elimination of GPC3-positive tumor cells. GPC3, a heparan sulfate proteoglycan and a member of the glypican family, is overexpressed on certain tumor cell types while minimally expressed on normal, healthy cells. GPC3 plays an important role in cellular proliferation and differentiation.Compared to conventional CAR T-cells, ECT204 may be less likely to stimulate cytokine release syndrome (CRS) and other cytokine-mediated toxicities."], "t": []}], "preferred_name": "ECT204", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C3282454", "l": "HUMAN CORD BLOOD HEMATOPOIETIC PROGENITOR CELL 500000000 in 25 mL INTRAVENOUS INJECTION [HemaCord]", "d": [], "t": []}], "preferred_name": "HUMAN CORD BLOOD HEMATOPOIETIC PROGENITOR CELL 500000000 in 25 mL INTRAVENOUS INJECTION [HemaCord]", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5154002", "l": "B lymphocytes | Blood | Cell markers", "d": [], "t": []}], "preferred_name": "B lymphocytes | Blood | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C2350623", "l": "Retinal Rod Cell", "d": [], "t": []}], "preferred_name": "Retinal Rod Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:2000088", "l": "Ammon's horn basket cell", "d": ["Any basket cell that is part of a Ammon's horn."], "t": []}], "preferred_name": "Ammon's horn basket cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1514741", "l": "Reactive Squamous Cell", "d": [], "t": []}, {"i": "NCIT:C36810", "l": "Reactive Squamous Cell", "d": [], "t": []}], "preferred_name": "Reactive Squamous Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:1000351", "l": "basal cell of epithelium of respiratory bronchiole", "d": ["A basal cell that is part of the epithelium of respiratory bronchiole."], "t": []}, {"i": "UMLS:C2335233", "l": "Basal cell of epithelium of respiratory bronchiole", "d": [], "t": []}], "preferred_name": "basal cell of epithelium of respiratory bronchiole", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4307038", "l": "Astro-TE NN_1 Myoc astrocyte (Mmus)", "d": ["A astrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Myoc (Mmus), Lhx2 (Mmus), Kcne1l (Mmus), Alpk1 (Mmus). It is distinguished from other Astro-TE NN_1 cells by expression of Myoc, Kcne1l, Alpk1. These cells are located in the Isocortex, Olfactory areas, brain . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5218 Astro-TE NN_1."], "t": []}], "preferred_name": "Astro-TE NN_1 Myoc astrocyte (Mmus)", "taxa": []}
{"type": "biolink:Cell", "ic": 40.193202611091465, "identifiers": [{"i": "UMLS:C1513959", "l": "Neoplastic Epithelial Cell", "d": [], "t": []}, {"i": "NCIT:C36753", "l": "Neoplastic Epithelial Cell", "d": [], "t": []}], "preferred_name": "Neoplastic Epithelial Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5984639", "l": "Allogeneic HPV-specific CD4+ T-lymphocytes", "d": [], "t": []}, {"i": "NCIT:C213014", "l": "Allogeneic HPV-specific CD4+ T-lymphocytes", "d": ["A preparation of allogeneic T-lymphocytes, collected from a haploidentical donor of the patient after vaccination with human papillomavirus (HPV) vaccine series, and depleted of CD8+ lymphocytes, with potential antiviral and antineoplastic activities. Upon administration, allogeneic HPV-specific CD4+ T-lymphocytes may induce selective toxicity in HPV-positive cancer cells and other HPV-infected cells. HPV is associated with various cancer cell types. The depletion of CD8+ lymphocytes from the donor cell preparation may lower the risk of graft-versus-host disease (GvHD)."], "t": []}], "preferred_name": "Allogeneic HPV-specific CD4+ T-lymphocytes", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1979641", "l": "Blast cell positive for CD24 antigen", "d": [], "t": []}, {"i": "SNOMEDCT:724264006", "l": "", "d": [], "t": []}], "preferred_name": "Blast cell positive for CD24 antigen", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4030025", "l": "renal cortical fibroblast", "d": ["A fibroblast that is located in the renal cortical interstitium."], "t": []}], "preferred_name": "renal cortical fibroblast", "taxa": []}
{"type": "biolink:Cell", "ic": 77.82747199602274, "identifiers": [{"i": "UMLS:C1514091", "l": "Neoplastic Small Neuroepithelial Cell", "d": [], "t": []}, {"i": "NCIT:C41835", "l": "Neoplastic Small Neuroepithelial Cell", "d": [], "t": []}], "preferred_name": "Neoplastic Small Neuroepithelial Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 87.18682603146104, "identifiers": [{"i": "UMLS:C1708899", "l": "Malignant Parathyroid Gland Chief Cell", "d": [], "t": []}, {"i": "NCIT:C48269", "l": "Malignant Parathyroid Gland Chief Cell", "d": [], "t": []}], "preferred_name": "Malignant Parathyroid Gland Chief Cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C2348423", "l": "Allogeneic CD4+ Memory Th1-like T Cells/Microparticle-bound Anti-CD3/anti-CD28", "d": [], "t": []}], "preferred_name": "Allogeneic CD4+ Memory Th1-like T Cells/Microparticle-bound Anti-CD3/anti-CD28", "taxa": []}
{"type": "biolink:Cell", "ic": 84.83823963392128, "identifiers": [{"i": "UMLS:C1708898", "l": "Malignant Parathyroid Gland Cell", "d": [], "t": []}, {"i": "NCIT:C48266", "l": "Malignant Parathyroid Gland Cell", "d": [], "t": []}], "preferred_name": "Malignant Parathyroid Gland Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "CL:0003051", "l": "UV cone cell", "d": ["A cone cell that detects ultraviolet (UV) wavelength light."], "t": []}], "preferred_name": "UV cone cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1267941", "l": "Lymphocyte positive for CD49F antigen", "d": [], "t": []}, {"i": "SNOMEDCT:117384005", "l": "", "d": [], "t": []}], "preferred_name": "Lymphocyte positive for CD49F antigen", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0000420", "l": "syncytial epithelial cell", "d": ["An epithelial cell that forms a syncytium, which is a multinucleated cell resulting from the fusion of multiple cells."], "t": []}], "preferred_name": "syncytial epithelial cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C2736927", "l": "Cell positive for CD13 antigen and HLA-DR antigen", "d": [], "t": []}, {"i": "SNOMEDCT:1373096004", "l": "", "d": [], "t": []}], "preferred_name": "Cell positive for CD13 antigen and HLA-DR antigen", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C6050268", "l": "Autologous Tumor-infiltrating Lymphocytes GT307", "d": [], "t": []}, {"i": "NCIT:C216088", "l": "Autologous Tumor-infiltrating Lymphocytes GT307", "d": ["A preparation of autologous tumor-infiltrating lymphocytes (TILs) derived from each patient's resected tumor and edited with the clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR associated protein 9 (Cas9) system to eliminate the expression of as of yet not elucidated immunoregulatory targets, with potential immunomodulating and antineoplastic activities. Upon administration back into the patient, autologous TILs GT307 specifically recognize and kill the patient's tumor cells. The knockout of the immunoregulatory targets may enhance the proliferation and cytokine release of the TILs."], "t": []}], "preferred_name": "Autologous Tumor-infiltrating Lymphocytes GT307", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1317193", "l": "CD23+CD38+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:1372998009", "l": "", "d": [], "t": []}], "preferred_name": "CD23+CD38+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5216294", "l": "Neutrophils|NCnc|Pt|Periton fld", "d": [], "t": []}], "preferred_name": "Neutrophils|NCnc|Pt|Periton fld", "taxa": []}
{"type": "biolink:Cell", "ic": 83.63771255585968, "identifiers": [{"i": "CL:0000104", "l": "multipolar neuron", "d": ["A neuron with three or more neurites, usually an axon and multiple dendrites."], "t": []}, {"i": "UMLS:C1513752", "l": "Multipolar neuron", "d": [], "t": []}, {"i": "NCIT:C33143", "l": "Multipolar Neuron", "d": ["A nerve cell with several processes, usually an axon and three or more dendrites."], "t": []}], "preferred_name": "multipolar neuron", "taxa": []}
{"type": "biolink:Cell", "ic": 90.871710685482, "identifiers": [{"i": "CL:0002623", "l": "acinar cell of salivary gland", "d": ["An acinar cell that is part of the salivary gland epithelium, responsible for synthesizing and secreting the primary saliva essential for oral digestion, antimicrobial defense, and mucosal immunity. It features apical-basal polarity with apical secretory granules, and tight junctions that maintain polarity and regulate calcium-dependent saliva exocytosis triggered by parasympathetic and sympathetic signals (Ambudkar, 2015). This cell functions in coordination with contractile myoepithelial cells, which aid saliva flow through the ducts into the oral cavity (Khan et al., 2022). In mice and humans, acinar cell development relies on the transcription factor SOX2 (Emmerson et al., 2017), with self-renewal achieved primarily through acinar cell self-duplication and supported by progenitor populations during injury and regeneration (Aure et al., 2016)."], "t": []}], "preferred_name": "acinar cell of salivary gland", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5171868", "l": "Macrophages | Peritoneal fluid | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Macrophages | Peritoneal fluid | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4052022", "l": "fallopian tube smooth muscle cell", "d": ["A smooth muscle cell that is part of the fallopian tube. This cell is responsible for peristaltic contractions that facilitate gamete and embryo transport, fluid mixing, and embryo admission to the uterus."], "t": []}], "preferred_name": "fallopian tube smooth muscle cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1267855", "l": "Lymphocyte positive for both CD8 antigen and CD28 antigen", "d": [], "t": []}, {"i": "SNOMEDCT:117540006", "l": "", "d": [], "t": []}], "preferred_name": "Lymphocyte positive for both CD8 antigen and CD28 antigen", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "CL:0002421", "l": "nucleated reticulocyte", "d": ["A reticulocyte that retains the nucleus and other organelles. Found in birds, fish, amphibians and reptiles."], "t": []}], "preferred_name": "nucleated reticulocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 64.16348156248243, "identifiers": [{"i": "CL:0001060", "l": "hematopoietic oligopotent progenitor cell, lineage-negative", "d": ["A hematopoietic oligopotent progenitor cell that has the ability to differentiate into limited cell types but lacks lineage cell markers and self renewal capabilities. Cell lacks hematopoeitic lineage markers."], "t": []}], "preferred_name": "hematopoietic oligopotent progenitor cell, lineage-negative", "taxa": []}
{"type": "biolink:Cell", "ic": 47.78695699092984, "identifiers": [{"i": "UMLS:C1518245", "l": "Malignant Squamous Cell", "d": [], "t": []}, {"i": "NCIT:C36771", "l": "Malignant Squamous Cell", "d": [], "t": []}], "preferred_name": "Malignant Squamous Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C2717959", "l": "Induced Pluripotent Stem Cells", "d": [], "t": []}, {"i": "NCIT:C124144", "l": "Induced Pluripotent Stem Cell", "d": ["Adult cells that have been genetically reprogrammed to an embryonic stem cell-like state by the expression of genes and factors important for maintaining the defining properties of embryonic stem cells."], "t": []}, {"i": "MESH:D057026", "l": "Induced Pluripotent Stem Cells", "d": [], "t": []}], "preferred_name": "Induced Pluripotent Stem Cells", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0002618", "l": "endothelial cell of umbilical vein", "d": ["An endothelial cell of the umbilical vein."], "t": []}], "preferred_name": "endothelial cell of umbilical vein", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1440250", "l": "CD120a+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:1372829005", "l": "", "d": [], "t": []}], "preferred_name": "CD120a+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5175152", "l": "Nucleated cells | Peritoneal fluid | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Nucleated cells | Peritoneal fluid | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1180238", "l": "Capillary Endothelial Cells", "d": [], "t": []}], "preferred_name": "Capillary Endothelial Cells", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:1000699", "l": "kidney resident dendritic cell", "d": ["A resident-dendritic cell that is part of a kidney."], "t": []}], "preferred_name": "kidney resident dendritic cell", "taxa": []}
{"type": "biolink:Cell", "ic": 85.53200374075534, "identifiers": [{"i": "UMLS:C1881597", "l": "Malignant Spindle Transitional Cell", "d": [], "t": []}, {"i": "NCIT:C60303", "l": "Malignant Spindle Transitional Cell", "d": [], "t": []}], "preferred_name": "Malignant Spindle Transitional Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 92.76600187037766, "identifiers": [{"i": "UMLS:C1519513", "l": "Pituitary TSH-Secreting Cells", "d": [], "t": []}, {"i": "NCIT:C33786", "l": "Thyrotroph Cell", "d": [], "t": []}, {"i": "MESH:D052684", "l": "Thyrotrophs", "d": [], "t": []}], "preferred_name": "Pituitary TSH-Secreting Cells", "taxa": []}
{"type": "biolink:Cell", "ic": 88.20185721311867, "identifiers": [{"i": "CL:0002367", "l": "trabecular meshwork cell", "d": ["An ocular connective tissue cell that is part of the eye's trabecular meshwork and is directly responsible for regulating the outflow of aqueous humor from the anterior chamber of the eye, thereby maintaining proper intraocular pressure."], "t": []}], "preferred_name": "trabecular meshwork cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0002513", "l": "Vgamma5-positive CD8-alpha alpha positive gamma-delta intraepithelial T cell", "d": ["A CD8-alpha alpha positive gamma-delta intraepithelial T cell that expresses a TCR encoded in part by the Vgamma5 gene segment."], "t": []}], "preferred_name": "Vgamma5-positive CD8-alpha alpha positive gamma-delta intraepithelial T cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4030016", "l": "epithelial cell of early distal convoluted tubule", "d": ["An epithelial cell located in the early distal convoluted tubule."], "t": []}], "preferred_name": "epithelial cell of early distal convoluted tubule", "taxa": []}
{"type": "biolink:Cell", "ic": 31.13806972295536, "identifiers": [{"i": "CL:0002319", "l": "neural cell", "d": ["A cell that is part of the nervous system."], "t": []}], "preferred_name": "neural cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5785378", "l": "Autologous Polyclonal Tumor Infiltrating Lymphocytes LYL845", "d": [], "t": []}, {"i": "NCIT:C192699", "l": "Autologous Polyclonal Tumor Infiltrating Lymphocytes LYL845", "d": ["A preparation of autologous, epigenetically reprogrammed, polyclonal tumor infiltrating lymphocytes (TILs), with potential immunomodulating and antineoplastic activities. The autologous TILs LYL845 are prepared and expanded ex vivo by co-culturing autologous tumor cells with specific Epi-R cell culture media containing optimized cytokine composition and cell activation which creates TILs enriched with CD8-positive T-cells with diverse tumor-reactive clones and an enhanced proportion of stem-like T-cells. Upon administration, the autologous TILs LYL845 may target and kill tumor cells and secrete pro-inflammatory cytokines. LYL845 shows increased durability of expanded TILs, enhanced polyclonality and increased tumor-reactive cytolytic T-cells compared to TILs derived from the standard process."], "t": []}], "preferred_name": "Autologous Polyclonal Tumor Infiltrating Lymphocytes LYL845", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4246712", "l": "Vascular smooth muscle cell of right coronary artery", "d": [], "t": []}], "preferred_name": "Vascular smooth muscle cell of right coronary artery", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1522117", "l": "Mouse Plasma Cell", "d": [], "t": []}, {"i": "NCIT:C22577", "l": "Mouse Plasma Cell", "d": [], "t": []}], "preferred_name": "Mouse Plasma Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 84.21065366064373, "identifiers": [{"i": "CL:0002097", "l": "cortical cell of adrenal gland", "d": ["A cell of the adrenal cortex. Cell types include those that synthesize and secrete chemical derivatives (steroids) of cholesterol."], "t": []}, {"i": "UMLS:C1181723", "l": "Cortical cell of adrenal gland", "d": [], "t": []}], "preferred_name": "cortical cell of adrenal gland", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0002610", "l": "raphe nuclei neuron", "d": ["A neuron of the raphe nuclei."], "t": []}], "preferred_name": "raphe nuclei neuron", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4033129", "l": "celiac ganglion PHI neuron", "d": ["A sympathetic neuron that has the soma located in the celiac ganglion and expresses the marker peptide histidine isoleucine (PHI)."], "t": []}], "preferred_name": "celiac ganglion PHI neuron", "taxa": []}
{"type": "biolink:Cell", "ic": 87.18682603146104, "identifiers": [{"i": "CL:1000742", "l": "glomerular mesangial cell", "d": ["A mesangial cell located among the glomerular capillaries in a renal corpuscle."], "t": []}, {"i": "UMLS:C1512199", "l": "Glomerular Mesangial Cells", "d": [], "t": []}, {"i": "NCIT:C32685", "l": "Glomerular Mesangial Cell", "d": ["Cells found within the glomerular lobules of mammalian kidney, where they serve as structural supports, may regulate blood flow, are phagocytic and may act as accessory cells, presenting antigen in immune responses."], "t": []}], "preferred_name": "glomerular mesangial cell", "taxa": []}
{"type": "biolink:Cell", "ic": 79.35380886648232, "identifiers": [{"i": "CL:0002605", "l": "astrocyte of the cerebral cortex", "d": ["A transcriptomically distinct astrocyte that is found in the cerebral cortex."], "t": []}], "preferred_name": "astrocyte of the cerebral cortex", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C2328733", "l": "Pseudo-unipolar neuron", "d": [], "t": []}], "preferred_name": "Pseudo-unipolar neuron", "taxa": []}
{"type": "biolink:Cell", "ic": 69.048893294565, "identifiers": [{"i": "CL:0000864", "l": "tissue-resident macrophage", "d": ["A macrophage constitutively resident in a particular tissue under non-inflammatory conditions, and capable of phagocytosing a variety of extracellular particulate material, including immune complexes, microorganisms, and dead cells."], "t": []}], "preferred_name": "tissue-resident macrophage", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1267999", "l": "Lymphocyte positive for CD120B antigen", "d": [], "t": []}, {"i": "SNOMEDCT:117439007", "l": "", "d": [], "t": []}], "preferred_name": "Lymphocyte positive for CD120B antigen", "taxa": []}
{"type": "biolink:Cell", "ic": 83.11065783093733, "identifiers": [{"i": "CL:0002096", "l": "internodal tract myocyte", "d": ["A specialised myocyte that lies between the sinoatrial node and the atrioventricular node and is involved in the conduction of electrical signals."], "t": []}, {"i": "UMLS:C2332129", "l": "Internodal tract myocyte", "d": [], "t": []}], "preferred_name": "internodal tract myocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C3898837", "l": "Hsp70-peptide TKD/IL-2-activated Autologous Natural Killer Cells", "d": [], "t": []}, {"i": "NCIT:C115969", "l": "Hsp70-peptide TKD/IL-2-activated Autologous Natural Killer Cells", "d": ["A preparation of autologous natural killer (NK) cells that are stimulated ex vivo by a 14-mer heat shock protein 70 (Hsp70) TKD peptide and interleukin-2 (IL-2), with potential tumor-selective cytolytic activity. Upon re-infusion into the patient, the treated NK cells recognize and bind to Hsp70-expressing tumor cells, which induces NK-mediated tumor cell lysis. Hsp70, a membrane-bound, stress-inducible protein, is overexpressed on almost all tumor cells; however, it is absent or minimally present on normal, healthy cells. TKD is the C-terminal substrate-binding domain of Hsp70 and is the structure recognized by the activated NK cells."], "t": []}], "preferred_name": "Hsp70-peptide TKD/IL-2-activated Autologous Natural Killer Cells", "taxa": []}
{"type": "biolink:Cell", "ic": 92.76600187037766, "identifiers": [{"i": "UMLS:C3178844", "l": "Mesenchymal Stromal Cells", "d": [], "t": []}, {"i": "NCIT:C179841", "l": "Mesenchymal Stromal Cell", "d": ["A heterogeneous, non-hematopoietic fibroblast-like cell with the potential for differentiating into connective tissue cells of multiple lineages.  It plays a significant role in tissue repair and regeneration, and interacts with immune cells to downregulate the immune response and enable immunosuppression via the induction of tolerance."], "t": []}], "preferred_name": "Mesenchymal Stromal Cells", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5157263", "l": "CD117 cells | Blood | Cell markers", "d": [], "t": []}], "preferred_name": "CD117 cells | Blood | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4310121", "l": "striatal SST-LYPD6-RSPO2 GABAergic interneuron (Primate)", "d": ["A GABAergic interneuron of the Primates brain. These cells are located in the striatum . Reference transcriptomic data for this type can be found in the dataset/taxonomy - HMBA Basal Ganglia Consensus Taxonomy in cell set Group:STR LYPD6-RSPO2 GABA."], "t": []}], "preferred_name": "striatal SST-LYPD6-RSPO2 GABAergic interneuron (Primate)", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C0000886", "l": "Acanthocytes", "d": [], "t": []}, {"i": "NCIT:C12523", "l": "Acanthocyte", "d": ["An abnormal red blood cell, characterized by an irregularly spiculated cell membrane, that is typically associated with abetalipoproteinemia or liver disease."], "t": []}, {"i": "MESH:D000050", "l": "Acanthocytes", "d": [], "t": []}, {"i": "SNOMEDCT:63599005", "l": "", "d": [], "t": []}], "preferred_name": "Acanthocytes", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C4329372", "l": "Autologous PD-1-targeted Chimeric Switch Receptor-modified T Lymphocytes", "d": [], "t": []}, {"i": "NCIT:C132251", "l": "Autologous PD-1-targeted Chimeric Switch Receptor-modified T Lymphocytes", "d": ["Autologous human T-lymphocytes that are genetically engineered to express a chimeric switch receptor (CSR) composed of the extracellular ligand binding domain of the human inhibitory receptor programmed cell death protein 1 (PD-1; PDCD1) fused to the transmembrane and cytoplasmic co-stimulatory signaling domains of CD28 (PD1CD28; PD-1:CD28 switch receptor), with potential immunomodulating and antineoplastic activities. Upon reintroduction of autologous PD-1-targeted CSR-modified T-lymphocytes into the patient, the switch receptor expressed by the engineered T-cells targets and binds to the PD-1 ligands, programmed cell death ligand 1 (PD-L1) and 2 (PD-L2) expressed, on tumor cells. The nature of the PD-1/CD28 switch receptor fusion protein prevents the normal PD1/PD-L1-mediated T-cell suppression and, instead, promotes signaling through the CD28 domain, which results in the stimulation of T-lymphocytes. This induces enhanced toxicity against PD-L1-expressing tumor cells. PD-1 protein, found on activated T-cells, negatively regulates T-cell activity; it plays a key role in immune evasion and prevents tumor cell lysis. Exchanging the transmembrane and intracellular domain of PD-1 with that of CD28 converts PD-L1 into a co-stimulation ligand of primary human CD8+ cytotoxic T-lymphocytes (CTLs). CD28, is a molecule expressed by T-cells that stimulates increased T-lymphocyte proliferation and activity."], "t": []}], "preferred_name": "Autologous PD-1-targeted Chimeric Switch Receptor-modified T Lymphocytes", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4253014", "l": "Set of enteroendocrine cells of epithelium of small intestine", "d": [], "t": []}], "preferred_name": "Set of enteroendocrine cells of epithelium of small intestine", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5216307", "l": "Platelets|NCnc|Pt|Bld", "d": [], "t": []}], "preferred_name": "Platelets|NCnc|Pt|Bld", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0002338", "l": "CD56-positive, CD161-positive immature natural killer cell, human", "d": ["A natural killer cell that is developmentally immature, has the phenotype CD34-negative, CD56-positive, CD117-positive, CD122-positive,and CD161-positive."], "t": []}], "preferred_name": "CD56-positive, CD161-positive immature natural killer cell, human", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0230519", "l": "Mitotic cell in prophase", "d": [], "t": []}, {"i": "SNOMEDCT:13056009", "l": "", "d": [], "t": []}], "preferred_name": "Mitotic cell in prophase", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5855011", "l": "Autologous Anti-CD3/Anti-SLAMF7 Bispecific Antibody-armed Activated T-lymphocytes", "d": [], "t": []}, {"i": "NCIT:C198647", "l": "Autologous Anti-CD3/Anti-SLAMF7 Bispecific Antibody-armed Activated T-lymphocytes", "d": ["A preparation of autologous activated T-lymphocytes that have been coated with a bispecific antibody comprised of an anti-CD3 monoclonal antibody heteroconjugated to an anti-signaling lymphocytic activation molecule family member 7 (SLAMF7; CD319; CRACC; CS-1) monoclonal antibody, with potential immunomodulating and antineoplastic activities. Upon administration, autologous anti-CD3/anti-SLAMF7 bispecific antibody-armed activated T-lymphocytes target and bind to both CD3 expressed on T-cells and SLAMF7 expressed on tumor cells, thereby cross-linking CD3-expressing T-cells and SLAMF7-expressing tumor cells. This results in the activation of cytotoxic T-lymphocytes (CTLs) and selective cytotoxicity towards SLAMF7-expressing tumor cells. In addition, cytokine and chemokine secretion by the T-cells further activates the immune system, which leads to the recruitment and activation of CTLs, and additional CTL-mediated tumor-specific cell lysis. SLAMF7 is a member of the signaling lymphocytic activation molecule (SLAM) family of transmembrane receptors that modulate the function of immune cells through immunoreceptor tyrosine-based switch motifs (ITSMs) and intracellular adaptor proteins. SLAMF7 is highly expressed on certain malignant plasma cells and is minimally expressed on healthy immune cells."], "t": []}], "preferred_name": "Autologous Anti-CD3/Anti-SLAMF7 Bispecific Antibody-armed Activated T-lymphocytes", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5157455", "l": "CD3+CD8+ (T8 suppressor) cells | Bone marrow | Cell markers", "d": [], "t": []}], "preferred_name": "CD3+CD8+ (T8 suppressor) cells | Bone marrow | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": 68.93024740242504, "identifiers": [{"i": "CL:0000790", "l": "immature alpha-beta T cell", "d": ["An alpha-beta T cell that has an immature phenotype and has not completed T cell selection."], "t": []}], "preferred_name": "immature alpha-beta T cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0004222", "l": "flag B amacrine cell", "d": ["A flag amacrine cell with post-synaptic terminals in S3, S4, and S5. This cell type releases the neurotransmitter glycine."], "t": []}], "preferred_name": "flag B amacrine cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5179528", "l": "Reticulocytes.low fluorescence/100 erythrocytes | Blood | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Reticulocytes.low fluorescence/100 erythrocytes | Blood | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5216254", "l": "Lymphocytes|NCnc|Pt|Plr fld", "d": [], "t": []}], "preferred_name": "Lymphocytes|NCnc|Pt|Plr fld", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "UMLS:C1708868", "l": "Malignant Corticotroph Cell", "d": [], "t": []}, {"i": "NCIT:C45944", "l": "Malignant Corticotroph Cell", "d": [], "t": []}], "preferred_name": "Malignant Corticotroph Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 70.74661260254285, "identifiers": [{"i": "UMLS:C1514080", "l": "Neoplastic Schwann Cell", "d": [], "t": []}, {"i": "NCIT:C37151", "l": "Neoplastic Schwann Cell", "d": [], "t": []}], "preferred_name": "Neoplastic Schwann Cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1257740", "l": "Swiss 3T3 Cells", "d": [], "t": []}, {"i": "MESH:D041701", "l": "Swiss 3T3 Cells", "d": [], "t": []}], "preferred_name": "Swiss 3T3 Cells", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C4683874", "l": "Atypical Glandular Cell-Favor Neoplasia", "d": [], "t": []}, {"i": "NCIT:C141517", "l": "Atypical Glandular Cell-Favor Neoplasia", "d": ["An abnormal endocervical or endometrial cell found in a cervical smear with cytologic features suggestive of a neoplastic process."], "t": []}], "preferred_name": "Atypical Glandular Cell-Favor Neoplasia", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1267857", "l": "Lymphocyte positive for both CD8 antigen and CD56 antigen", "d": [], "t": []}, {"i": "SNOMEDCT:116816001", "l": "", "d": [], "t": []}], "preferred_name": "Lymphocyte positive for both CD8 antigen and CD56 antigen", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C4287655", "l": "Autologous MAGE-A10-specific HLA-A2-restricted TCR c796 Gene-engineered Lymphocytes", "d": [], "t": []}, {"i": "NCIT:C126686", "l": "Autologous MAGE-A10-specific HLA-A2-restricted TCR c796 Gene-engineered Lymphocytes", "d": ["Human autologous T-lymphocytes transduced with a retroviral vector encoding a high-affinity T-cell receptor (TCR) specific for human leukocyte antigen (HLA)-A2-restricted, human melanoma-associated antigen A10 (MAGE-A10), clone 796 (c796), with potential antineoplastic activity. Peripheral blood mononuclear cells (PBMCs) are isolated from a patient, transduced with an anti-MAGE-A10(c796)-HLA-A2 restricted TCR, expanded ex vivo, and reintroduced into the HLA-A2-positive patient. Upon reintroduction, the autologous MAGE-A10-specific, HLA-A2-restricted TCR c796 gene-engineered lymphocytes bind to tumor cells expressing the MAGE-A10 antigen, which may induce cell death in and halt the growth of MAGE-A10-expressing cancer cells. The tumor-associated antigen MAGE-A10, a member of the MAGE-A family of cancer/testis tumor-associated antigens (CT-TAAs), is overexpressed by a variety of cancer cell types."], "t": []}], "preferred_name": "Autologous MAGE-A10-specific HLA-A2-restricted TCR c796 Gene-engineered Lymphocytes", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5181480", "l": "Spherocytes.micro | Blood | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Spherocytes.micro | Blood | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5170944", "l": "Leukocytes | Urine sediment | Urinalysis", "d": [], "t": []}], "preferred_name": "Leukocytes | Urine sediment | Urinalysis", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C2350150", "l": "Pronormoblasts", "d": [], "t": []}], "preferred_name": "Pronormoblasts", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4033181", "l": "dorsal root ganglion Piezo2 neuron", "d": ["A sensory neuron that has the soma located in the dorsal root ganglion and expresses the marker piezo-type mechanosensitive ion channel component 2 (Piezo2). Piezo2 is the primary mechanotransduction channel and is present in approximately 35% of TrkA-positive human DRG neurons."], "t": []}], "preferred_name": "dorsal root ganglion Piezo2 neuron", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4253023", "l": "Set of enteroendocrine cells", "d": [], "t": []}], "preferred_name": "Set of enteroendocrine cells", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0009114", "l": "monocytoid B cell", "d": ["A B cell found in the perisinusoidal area of a lymph node. In humans, monocytoid B cells are a morphologically distinct B cell population\n(oval nuclei, abundant cytoplasm, monocyte-like appearance), share many similarities with marginal zone B cells including marker expression, and are increased in disease settings."], "t": []}], "preferred_name": "monocytoid B cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5417828", "l": "Autologous 1928T2z CAR T-cells WZTL-002", "d": [], "t": []}, {"i": "NCIT:C170905", "l": "Autologous 1928T2z CAR T-cells WZTL-002", "d": ["A preparation of autologous, third-generation T-lymphocytes that have been transduced with a self-inactivating lentiviral vector to express a chimeric antigen receptor (CAR) containing a single-chain variable fragment (scFv) from the monoclonal antibody FMC63, which is directed against the CD19 antigen, and linked to the co-stimulatory intracellular signaling domains of CD28 and the zeta chain of the TCR/CD3 complex (CD3-zeta) (CD28zeta; CD28z), and the Toll/interleukin-1 receptor (TIR) domain from Toll-like receptor 2 (TLR2) as an additional co-stimulatory domain, with potential immunostimulating and antineoplastic activities. Upon administration, the autologous 1928T2z CAR T-cells WZTL-002 specifically recognize and bind to CD19-expressing tumor cells, resulting in specific T-cell-mediated tumor cell lysis. CD19 antigen is a B-cell specific cell surface antigen, which is expressed in all B-cell lineage malignancies and normal B-cells. In addition to CD28 and CD3zeta, the TLR2-TIR domain provides co-stimulatory activity and may enhance the cytotoxic effect and anti-tumor activity of the CAR T-cells. The TIR domain from TLR2 mediates the intracellular signaling of TLR2; TLR2 stimulation enhances T-cell activation, proliferation and cytokine production."], "t": []}], "preferred_name": "Autologous 1928T2z CAR T-cells WZTL-002", "taxa": []}
{"type": "biolink:Cell", "ic": 83.11065783093733, "identifiers": [{"i": "UMLS:C1514032", "l": "Neoplastic Protoplasmic Astrocyte", "d": [], "t": []}, {"i": "NCIT:C41459", "l": "Neoplastic Protoplasmic Astrocyte", "d": [], "t": []}], "preferred_name": "Neoplastic Protoplasmic Astrocyte", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0427567", "l": "Microthrombocyte", "d": [], "t": []}, {"i": "SNOMEDCT:250316002", "l": "", "d": [], "t": []}], "preferred_name": "Microthrombocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4052031", "l": "respiratory airway secretory cell", "d": ["A secretory epithelial cell of the respiratory and terminal bronchioles."], "t": []}], "preferred_name": "respiratory airway secretory cell", "taxa": []}
{"type": "biolink:Cell", "ic": 87.18682603146104, "identifiers": [{"i": "CL:4072003", "l": "mature myelinating oligodendrocyte", "d": ["A post-mitotic oligodendrocyte derived from a myelin-forming oligodendrocyte (MFOL). A mature Myelinating Oligodendrocyte is a fully differentiated cell that is actively engaged in myelination. In addition to high expression of canonical myelin genes (e.g., Mbp, Plp1, Mog), a MOL can be distinguished by the expression of stage-enriched genes Grm3, Klk6, Ptgds, Anxa5, and Hopx in mice. These markers reflect the functional specialization of a mature oligodendrocyte, including roles in signalling, lipid metabolism, and myelin maintenance."], "t": []}], "preferred_name": "mature myelinating oligodendrocyte", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1440362", "l": "CD85+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:1372938006", "l": "", "d": [], "t": []}], "preferred_name": "CD85+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C4764235", "l": "Autologous Anti-MUC1*-CAR-4-1BB-CD3zeta-expressing T-lymphocytes", "d": [], "t": []}, {"i": "NCIT:C158439", "l": "Autologous Anti-MUC1*-CAR-4-1BB-CD3zeta-expressing T-lymphocytes", "d": ["A preparation of autologous T-lymphocytes transduced with a lentiviral vector encoding a human CD8 alpha leader sequence, a humanized MNC2-single chain variable fragment (scFv) targeting the extracellular domain of the cleaved form of mucin-1 (MUC-1), known as MUC1*, portions of human CD8 hinge and transmembrane domains, and human 4-1BB and human CD3-zeta costimulatory domains, with potential antineoplastic and immunostimulating activities. Upon re-introduction into the patient, the autologous anti-MUC1*-CAR-4-1BB-CD3zeta-expressing T-lymphocytes specifically recognize and induce selective toxicity in MUC1*-expressing tumor cells. MUC1* is a post-translationally modified form of MUC1, a single pass type I transmembrane protein that is normally expressed in the glandular or luminal epithelial cells of the esophagus, stomach, duodenum, pancreas, uterus, prostate, and lungs, and may be aberrantly expressed in certain tumor types. MUC1* is a growth factor that is activated by ligand-induced dimerization of its extracellular domain, which may stimulate mitogen-activated protein kinase (MAP kinase, MAPK) signaling and promote tumor cell growth. MUC1* is frequently expressed in certain cancer types, with increased expression noted in higher grade lesions and tumor cells resistant to certain chemotherapies."], "t": []}], "preferred_name": "Autologous Anti-MUC1*-CAR-4-1BB-CD3zeta-expressing T-lymphocytes", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0882836", "l": "CD3+CD8+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:732280007", "l": "", "d": [], "t": []}], "preferred_name": "CD3+CD8+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C3176805", "l": "Blasts.cytoplasmic CD22", "d": [], "t": []}], "preferred_name": "Blasts.cytoplasmic CD22", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5555558", "l": "Anti-GD2/PSMA/CD276 4SCAR-expressing T-cells", "d": [], "t": []}, {"i": "NCIT:C179257", "l": "Anti-GD2/PSMA/CD276 4SCAR-expressing T-cells", "d": ["A preparation of  T-cells that are genetically engineered to express fourth generation chimeric antigen receptors (4SCARs) targeting the three tumor-associated antigens (TAAs) prostate-specific membrane antigen (PSMA), disialoganglioside (GD2), and the immune checkpoint molecule protein B7-homologue 3 (B7-H3, CD276), coupled to the costimulatory signaling domains CD28, CD137, CD27 and the zeta chain of the T-cell receptor (CD3zeta; CD3z), and fused with the suicide gene inducible caspase 9 (iCasp9), with potential immunostimulating and antineoplastic activities. Upon administration, the anti-GD2/PSMA/CD276-4SCAR-expressing T-cells are directed to and induce selective toxicity in GD2-, PSMA- and CD276-expressing tumor cells. iCasp9 consists of a human FK506 drug-binding domain with an F36V mutation (FKBP12-F36V) linked to human caspase 9. If the administered T-cells lead to unacceptable side effects, the chemical homodimerizer AP1903 can be administered. AP1903 binds to the drug binding FKBP12-F36V domain and induces activation of caspase 9, which results in the apoptosis of the administered T-cells and enhances safety of this agent. PSMA, a type II transmembrane protein, is expressed on the membrane of prostatic epithelial cells and overexpressed on prostate tumor cells as well as a variety of other solid tumors, including brain tumor, neuroblastoma (NB) and some lymphoma tumor tissues. CD276, a type I transmembrane protein and a member of the B7 co-stimulatory protein superfamily, is highly expressed on many solid tumors including NB. It is a negative regulator of the T-cell activation and plays a key role in tumor evasion. GD2 is overexpressed on the surface of NB cells and by other neuroectoderm-derived neoplasms, while it is minimally expressed on normal cells. CD28, CD137 and CD27, T-cell surface-associated co-stimulatory molecules, are required for full T-cell activation and enhance both proliferation of T-cells and antitumor activity."], "t": []}], "preferred_name": "Anti-GD2/PSMA/CD276 4SCAR-expressing T-cells", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5239341", "l": "WT1-loaded Artificial Adjuvant Vector Cell Immunotherapeutic ASP7517", "d": [], "t": []}, {"i": "NCIT:C169049", "l": "WT1-loaded Artificial Adjuvant Vector Cell Immunotherapeutic ASP7517", "d": ["A preparation of artificial adjuvant vector cells (aAVCs) composed of cells from the cell line HEK293, which is derived from human embryonic kidney cells, that are transfected with the natural killer T (NKT) immune cell receptor cluster of differentiation 1d (CD1d) and loaded with the glycolipid and CD1d ligand alpha-galactosylceramide (alpha-GalCer) on the cell surface, and loaded with the full-length tumor-associated antigen (TAA) Wilms' tumor 1 (WT1), with potential immunomodulating and antineoplastic activities. Upon administration of the WT1-loaded aAVC immunotherapeutic ASP7517, the alphaGalCer on the cell surface activates invariant NKT (iNKT) cells, thereby eliciting WT1-specific NKT cell responses against ASP7517. This in turn activates a natural killer (NK) cell response against WT1-expressing tumor cells. Also, the WT1 released from destroyed ASP7517 is taken up by antigen-presenting cells (APCs), mainly by dendritic cells (DCs), which in turn activates cytotoxic T-lymphocytes (CTL) and results in a CTL-mediated immune response against WT1-expressing tumor cells, thereby further destroying WT1-expressing tumor cells. In addition, the activation of antigen-specific memory T cells provides long-lasting anti-tumor effects against the WT1-expressing tumor cells."], "t": []}], "preferred_name": "WT1-loaded Artificial Adjuvant Vector Cell Immunotherapeutic ASP7517", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C4724886", "l": "Autologous Mesenchymal Stem Cells-Poly Lactic-co-glycolic Acid", "d": [], "t": []}, {"i": "NCIT:C148189", "l": "Autologous Mesenchymal Stem Cells-Poly Lactic-co-glycolic Acid", "d": ["A preparation of autologous bone marrow derived mesenchymal stem cells (MSC) that are seeded on biodegradable poly lactic-co-glycolic acid (PLGA)-containing polymer scaffolds, that can potentially be used for bone marrow engraftment. When administered into the bone lesion of the patient, the autologous MSC-PLGA can be used for bone marrow engraftment."], "t": []}], "preferred_name": "Autologous Mesenchymal Stem Cells-Poly Lactic-co-glycolic Acid", "taxa": []}
{"type": "biolink:Cell", "ic": 80.96785908349635, "identifiers": [{"i": "CL:0000216", "l": "Sertoli cell", "d": ["A supporting cell projecting inward from the basement membrane of seminiferous tubules. They surround and nourish the developing male germ cells and secrete androgen binding protein. Their tight junctions with the spermatogonia and spermatocytes provide a blood-testis barrier."], "t": []}, {"i": "UMLS:C0036770", "l": "Structure of sertoli cell", "d": [], "t": []}, {"i": "NCIT:C12595", "l": "Sertoli Cell", "d": ["Elongated cells in the seminiferous tubules to which spermatids are attached during spermiogenesis; they secrete androgen-binding protein and establish the blood-testis barrier by forming tight junctions with adjacent Sertoli's cells."], "t": []}, {"i": "MESH:D012708", "l": "Sertoli Cells", "d": [], "t": []}, {"i": "SNOMEDCT:40281007", "l": "", "d": [], "t": []}], "preferred_name": "Sertoli cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1510781", "l": "Adenocarcinoma Cell with Intranuclear Inclusion", "d": [], "t": []}, {"i": "NCIT:C36876", "l": "Adenocarcinoma Cell with Intranuclear Inclusion", "d": [], "t": []}], "preferred_name": "Adenocarcinoma Cell with Intranuclear Inclusion", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1515150", "l": "TE32", "d": [], "t": []}, {"i": "NCIT:C20297", "l": "TE32", "d": ["Provider: Technion University, Haifa, Israel. No information from provider. This cell line meets the criteria for the use of human embryonic stem cells by federally funded researchers."], "t": []}], "preferred_name": "TE32", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:1000338", "l": "enterocyte of epithelium of crypt of Lieberkuhn of small intestine", "d": ["An enterocyte that is part of the epithelium of crypt of Lieberkuhn of small intestine."], "t": []}, {"i": "UMLS:C2339635", "l": "Enterocyte of epithelium of crypt of Lieberkuhn of small intestine", "d": [], "t": []}], "preferred_name": "enterocyte of epithelium of crypt of Lieberkuhn of small intestine", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C2339528", "l": "Retinal astrocyte", "d": [], "t": []}], "preferred_name": "Retinal astrocyte", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0682549", "l": "argentaffin cell (stain)", "d": [], "t": []}], "preferred_name": "argentaffin cell (stain)", "taxa": []}
{"type": "biolink:Cell", "ic": 62.44248113822024, "identifiers": [{"i": "CL:0002251", "l": "epithelial cell of alimentary canal", "d": ["An epithelial cell of the musculomembranous digestive tube extending from the mouth to the anus."], "t": []}], "preferred_name": "epithelial cell of alimentary canal", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5854487", "l": "Autologous Gene-modified PD-1-positive T-lymphocytes ScTIL210", "d": [], "t": []}, {"i": "NCIT:C200166", "l": "Autologous Gene-modified PD-1-positive T-lymphocytes ScTIL210", "d": ["A preparation of autologous programmed cell death protein 1 (PD-1; PDCD1; CD279)-positive T-lymphocytes transduced with a lentiviral vector encoding for an as of yet undisclosed receptor, with potential immunomodulating activity. Upon administration, autologous gene-modified PD-1-positive T-lymphocytes ScTIL210 may recognize and kill the patient's tumor cells through as of yet not elucidated receptor binding."], "t": []}], "preferred_name": "Autologous Gene-modified PD-1-positive T-lymphocytes ScTIL210", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5216207", "l": "Erythrocytes.nucleated|NCnc|Pt|Body fld", "d": [], "t": []}], "preferred_name": "Erythrocytes.nucleated|NCnc|Pt|Body fld", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5171872", "l": "Macrophages | Vitreous fluid | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Macrophages | Vitreous fluid | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": 83.63771255585968, "identifiers": [{"i": "CL:0002167", "l": "olfactory epithelial cell", "d": ["A specialized cell involved in sensory perception of smell."], "t": []}, {"i": "UMLS:C1180326", "l": "Olfactory epithelial cell", "d": [], "t": []}, {"i": "NCIT:C13150", "l": "Olfactory Epithelial Cell", "d": ["A cell found in the pseudostratified epithelium lining the olfactory region of the nasal cavity. The olfactory epithelium has three major cell types - olfactory receptor cells, basal cell and sustentacular cells."], "t": []}], "preferred_name": "olfactory epithelial cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5382812", "l": "Cytomegalovirus-specific CD8 cells | Blood | Cell markers", "d": [], "t": []}], "preferred_name": "Cytomegalovirus-specific CD8 cells | Blood | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": 92.76600187037766, "identifiers": [{"i": "CL:0000880", "l": "choroid plexus macrophage", "d": ["A border associated macrophage found at the interface between the blood and the cerebrospinal fluid in the brain. This central nervous system macrophage has a star-like shaped body and expresses scavenger receptors."], "t": []}], "preferred_name": "choroid plexus macrophage", "taxa": []}
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{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1317333", "l": "Erythrocytes.lytic resistant", "d": [], "t": []}], "preferred_name": "Erythrocytes.lytic resistant", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5787225", "l": "CAR-NK019", "d": [], "t": []}], "preferred_name": "CAR-NK019", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4038494", "l": "Cells.aneuploid.S phase population 2", "d": [], "t": []}], "preferred_name": "Cells.aneuploid.S phase population 2", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "CL:0005005", "l": "cyanoblast", "d": ["A non-terminally differentiated cell that originates from the neural crest and differentiates into a cyanophore."], "t": []}], "preferred_name": "cyanoblast", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C6054158", "l": "Enlarged Spermatocyte", "d": [], "t": []}, {"i": "NCIT:C221701", "l": "Enlarged Spermatocyte", "d": ["Spermatocytes that appear enlarged and are considered to be individual germ cells arrested during meiosis"], "t": []}], "preferred_name": "Enlarged Spermatocyte", "taxa": []}
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{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5761852", "l": "GPRC5D-CAR-T", "d": [], "t": []}], "preferred_name": "GPRC5D-CAR-T", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "CL:4072104", "l": "fibrochondrocyte", "d": ["A chondrocyte with hybrid fibroblastic-chondrogenic characteristics found in fibrocartilage, particularly in the avascular inner zone and transitional middle zone of the meniscus. In humans, fibrochondrocytes are marked by predominant expression of type I collagen (COL1A1) and fibril-associated collagens (COL3A1, COL6A1), while retaining type II collagen (COL2A1) expression and exhibiting lower SOX9 than hyaline chondrocytes. This molecular profile underlies the synthesis of abundant type I collagen essential for fibrocartilage matrix and reflects an intermediate phenotype between fibroblast and chondrocyte."], "t": []}], "preferred_name": "fibrochondrocyte", "taxa": []}
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{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C3828708", "l": "Oncolytic Adenovirus ICOVIR5-infected Autologous Mesenchymal Stem Cells", "d": [], "t": []}, {"i": "NCIT:C107160", "l": "Oncolytic Adenovirus ICOVIR5-infected Autologous Mesenchymal Stem Cells", "d": ["Bone marrow-derived autologous mesenchymal stem cells (MSCs) infected with the oncolytic, replication-competent adenovirus ICOVIR5, with potential antineoplastic activity. Upon infusion of the oncolytic adenovirus ICOVIR5-infected autologous MSCs, these cells target the adenovirus to tumors. The oncolytic virus then selectively transfects and replicates in the tumor cells causing a direct cytotoxic effect and lysis of the tumor cells. In addition, the viral infection may stimulate an immune response against the virally-infected tumor cells. This may lead to an inhibition of cancer cell proliferation. ICOVIR-5, a virus derived from wild-type human adenovirus serotype 5 (Had5), has been modified to selectively replicate in tumor cells that have a deregulated retinoblastoma/E2F pathway."], "t": []}], "preferred_name": "Oncolytic Adenovirus ICOVIR5-infected Autologous Mesenchymal Stem Cells", "taxa": []}
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{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5182912", "l": "Terminal deoxyribonucleotidyl transferase cells | Body fluid | Cell markers", "d": [], "t": []}], "preferred_name": "Terminal deoxyribonucleotidyl transferase cells | Body fluid | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "UMLS:C0035286", "l": "Reticulocytes", "d": [], "t": []}, {"i": "NCIT:C12528", "l": "Reticulocyte", "d": ["Immature erythrocytes that have just undergone extrusion of their cell nucleus. They still contain some organelles that gradually decrease in number as the cells mature."], "t": []}, {"i": "MESH:D012156", "l": "Reticulocytes", "d": [], "t": []}, {"i": "SNOMEDCT:52802009", "l": "", "d": [], "t": []}], "preferred_name": "Reticulocytes", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1959571", "l": "Suppressor T-Lymphocytes, Naturally-Occurring", "d": [], "t": []}], "preferred_name": "Suppressor T-Lymphocytes, Naturally-Occurring", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1267946", "l": "Lymphocyte positive for CD54 antigen", "d": [], "t": []}, {"i": "SNOMEDCT:117389000", "l": "", "d": [], "t": []}], "preferred_name": "Lymphocyte positive for CD54 antigen", "taxa": []}
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{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0004234", "l": "diffuse multistratified amacrine cell", "d": ["An amacrine cell with a medium dendritic field and post-synaptic terminals in S2, and in S3-S4."], "t": []}], "preferred_name": "diffuse multistratified amacrine cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5186857", "l": "Nucleated erythrocytes | Fetus | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Nucleated erythrocytes | Fetus | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5157265", "l": "CD11a blasts | Blood | Cell markers", "d": [], "t": []}], "preferred_name": "CD11a blasts | Blood | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0546445", "l": "Russell-Crooke cell", "d": [], "t": []}], "preferred_name": "Russell-Crooke cell", "taxa": []}
{"type": "biolink:Cell", "ic": 90.871710685482, "identifiers": [{"i": "CL:4047034", "l": "smooth muscle cell of stomach", "d": ["A smooth muscle cell that is part of the muscularis externa of the stomach wall. It is characterized by its fusiform shape, involuntary control, and ability to generate slow, sustained contractions. This cell is organized in distinct layers and is essential for gastric motility and digestion."], "t": []}], "preferred_name": "smooth muscle cell of stomach", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4023003", "l": "nuclear chain fiber", "d": ["A type of intrafusal muscle fiber that has nuclei arranged in a linear row. Unlike nuclear bag fibers, the equatorial region of these fibers (in the centre of the spindle) is not expanded. These fibers are responsible for the detection of changes in muscle length. They are innervated by static gamma motor neurons and are principally associated with type II sensory fibers."], "t": []}], "preferred_name": "nuclear chain fiber", "taxa": []}
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{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5205962", "l": "Autologous Anti-SLAMF7 CAR-expressing T-cells", "d": [], "t": []}, {"i": "NCIT:C161635", "l": "Autologous Anti-SLAMF7 CAR-expressing T-cells", "d": ["A preparation of autologous T-lymphocytes that have been genetically modified to express a chimeric antigen receptor (CAR) recognizing human SLAM family member 7 (SLAMF7; CD319 CRACC; CS-1) with potential antineoplastic activity. Upon intravenous administration, the autologous anti-SLAMF7 CAR-expressing T-cells target and induce selective toxicity in SLAMF7-expressing tumor cells. SLAMF7 is a member of the signaling lymphocytic activation molecule (SLAM) family of transmembrane receptors that modulate the function of immune cells through immunoreceptor tyrosine-based switch motifs (ITSMs) and intracellular adaptor proteins. SLAMF7 is highly expressed on certain malignant plasma cells and is minimally expressed on healthy immune cells."], "t": []}], "preferred_name": "Autologous Anti-SLAMF7 CAR-expressing T-cells", "taxa": []}
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{"type": "biolink:Cell", "ic": 78.80476858236055, "identifiers": [{"i": "CL:0000709", "l": "R8 photoreceptor cell", "d": [], "t": []}], "preferred_name": "R8 photoreceptor cell", "taxa": []}
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{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5960292", "l": "Osencabtagene Autoleucel", "d": [], "t": []}, {"i": "NCIT:C207225", "l": "Osencabtagene Autoleucel", "d": [], "t": []}], "preferred_name": "Osencabtagene Autoleucel", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0002567", "l": "light melanocyte", "d": ["A melanocyte that appears lighter in color."], "t": []}], "preferred_name": "light melanocyte", "taxa": []}
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{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1440385", "l": "Cells.euploid+Cells.aneuploid.population 1", "d": [], "t": []}], "preferred_name": "Cells.euploid+Cells.aneuploid.population 1", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0230517", "l": "Dividing cell", "d": [], "t": []}, {"i": "SNOMEDCT:35853008", "l": "", "d": [], "t": []}], "preferred_name": "Dividing cell", "taxa": []}
{"type": "biolink:Cell", "ic": 39.89699065071225, "identifiers": [{"i": "UMLS:C1510716", "l": "Abnormal Connective and Soft Tissue Cell", "d": [], "t": []}, {"i": "NCIT:C36843", "l": "Abnormal Connective and Soft Tissue Cell", "d": [], "t": []}], "preferred_name": "Abnormal Connective and Soft Tissue Cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C3495621", "l": "A15 cell group", "d": [], "t": []}], "preferred_name": "A15 cell group", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5908922", "l": "renizgamglogene autogedtemcel", "d": [], "t": []}, {"i": "NCIT:C203030", "l": "Renizgamglogene Autogedtemcel", "d": [], "t": []}], "preferred_name": "renizgamglogene autogedtemcel", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C3495620", "l": "A11 dopamine cells", "d": [], "t": []}], "preferred_name": "A11 dopamine cells", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1979149", "l": "Blasts.CD135", "d": [], "t": []}], "preferred_name": "Blasts.CD135", "taxa": []}
{"type": "biolink:Cell", "ic": 92.76600187037766, "identifiers": [{"i": "CL:0002119", "l": "CD38-positive IgG-negative class switched memory B cell", "d": ["A CD38-positive IgG-negative memory B cell is an IgG-negative class switched memory B cell that lacks IgG on the cell surface with the phenotype CD38-positive and IgG-negative."], "t": []}], "preferred_name": "CD38-positive IgG-negative class switched memory B cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5416853", "l": "Allogeneic Umbilical Cord Blood Derived Regulatory T-Cells", "d": [], "t": []}], "preferred_name": "Allogeneic Umbilical Cord Blood Derived Regulatory T-Cells", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4745265", "l": "ALLOGENEIC UMBILICAL CORD BLOOD-DERIVED HEMATOPOIETIC STEM AND PROGENITOR CELLS MGTA-456", "d": [], "t": []}], "preferred_name": "ALLOGENEIC UMBILICAL CORD BLOOD-DERIVED HEMATOPOIETIC STEM AND PROGENITOR CELLS MGTA-456", "taxa": []}
{"type": "biolink:Cell", "ic": 75.38868324457971, "identifiers": [{"i": "CL:1000428", "l": "stem cell of epidermis", "d": ["A somatic stem cell that is part of the epidermis."], "t": []}, {"i": "UMLS:C1182604", "l": "Stem cell of epidermis", "d": [], "t": []}], "preferred_name": "stem cell of epidermis", "taxa": []}
{"type": "biolink:Cell", "ic": 63.85716266402846, "identifiers": [{"i": "CL:0000333", "l": "migratory neural crest cell", "d": ["A cell derived from the specialized ectoderm flanking each side of the embryonic neural plate, which after the closure of the neural tube, forms masses of cells that migrate out from the dorsal aspect of the neural tube to spread throughout the body."], "t": []}], "preferred_name": "migratory neural crest cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5157295", "l": "CD13 blasts | Blood | Cell markers", "d": [], "t": []}], "preferred_name": "CD13 blasts | Blood | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0002451", "l": "mammary stem cell", "d": ["A multi-fate stem cell that is the source of cells for growth of the mammary gland during puberty and gestation. This cell type gives rise to both the luminal and myoepithelial cell types of the gland, and have been shown to have the ability to regenerate the entire organ in mice. This cell type also plays an important role in carcinogenesis of the breast. This cell type is Lin-, CD24-positive, CD29-hi."], "t": []}], "preferred_name": "mammary stem cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5705651", "l": "NEURONATA-R", "d": [], "t": []}], "preferred_name": "NEURONATA-R", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0019017", "l": "lymphatic vessel smooth muscle cell", "d": ["A smooth muscle cell that is part of any lymphatic vessel."], "t": []}], "preferred_name": "lymphatic vessel smooth muscle cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0000949", "l": "IgD plasmablast", "d": ["A plasmablast that secretes IgD, and which occur in a small proportion of B cells in the adult."], "t": []}], "preferred_name": "IgD plasmablast", "taxa": []}
{"type": "biolink:Cell", "ic": 92.76600187037766, "identifiers": [{"i": "UMLS:C0225700", "l": "Type-II Pneumocytes", "d": [], "t": []}, {"i": "NCIT:C32055", "l": "Alveolar Cell Type II", "d": ["A pleomorphic cell of the pulmonary alveolar epithelium that secretes surfactant and is distinguished by abundant cytoplasm containing numerous lipid-rich multilamellar bodies."], "t": []}, {"i": "SNOMEDCT:52782001", "l": "", "d": [], "t": []}], "preferred_name": "Type-II Pneumocytes", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1979649", "l": "Blasts.cytoplasmic CD2", "d": [], "t": []}], "preferred_name": "Blasts.cytoplasmic CD2", "taxa": []}
{"type": "biolink:Cell", "ic": 44.893398985673166, "identifiers": [{"i": "UMLS:C1512385", "l": "Hematopoietic and Lymphoid Cell", "d": [], "t": []}, {"i": "NCIT:C32725", "l": "Hematopoietic and Lymphoid Cell", "d": ["One of the cells of the blood or bone marrow, a leukocyte or erythrocyte."], "t": []}], "preferred_name": "Hematopoietic and Lymphoid Cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5216240", "l": "Leukocytes|NCnc|Pt|Stool", "d": [], "t": []}], "preferred_name": "Leukocytes|NCnc|Pt|Stool", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5216319", "l": "Sezary cells|NCnc|Pt|Bld", "d": [], "t": []}], "preferred_name": "Sezary cells|NCnc|Pt|Bld", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5554878", "l": "Single Cell Specimen", "d": [], "t": []}, {"i": "NCIT:C178226", "l": "Single Cell Specimen", "d": ["A biospecimen that contains the contents of a single cell."], "t": []}], "preferred_name": "Single Cell Specimen", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C4725083", "l": "Autologous BCMA-4-1BBz-targeted CAR T-cells", "d": [], "t": []}, {"i": "NCIT:C148506", "l": "Autologous BCMA-4-1BBz-targeted CAR T-cells", "d": ["A preparation of autologous T-lymphocytes that have been ex vivo transduced with a retroviral vector expressing a chimeric antigen receptor (CAR) containing a single chain variable fragment (scFv) specific for the human tumor-associated antigen (TAA) B-cell maturation antigen (BCMA; tumor necrosis factor receptor superfamily member 17; TNFRSF17) fused to the co-stimulatory domain of 4-1BB (CD137), and the CD3-zeta (CD3z) T-cell signaling domain (4-1BBz), with potential immunostimulating and antineoplastic activities. Upon administration, the autologous BCMA-4-1BBz-targeted CAR T-cells specifically recognize and induce selective toxicity in BCMA-expressing tumor cells. BCMA, a receptor for both a proliferation-inducing ligand (APRIL) and B-cell activating factor (BAFF), is a member of the tumor necrosis factor receptor superfamily (TNFRSF). BCMA is found on the surfaces of plasma cells; it is overexpressed on malignant plasma cells, and plays a key role in plasma cell survival."], "t": []}], "preferred_name": "Autologous BCMA-4-1BBz-targeted CAR T-cells", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0427527", "l": "Cleft lymphocyte", "d": [], "t": []}, {"i": "SNOMEDCT:134202006", "l": "", "d": [], "t": []}], "preferred_name": "Cleft lymphocyte", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1954356", "l": "X linked heterotaxy", "d": [], "t": []}], "preferred_name": "X linked heterotaxy", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0229425", "l": "Primary sclerotic mastoid cell", "d": [], "t": []}, {"i": "SNOMEDCT:57003005", "l": "", "d": [], "t": []}], "preferred_name": "Primary sclerotic mastoid cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4030035", "l": "dental pulp stem cell", "d": ["A dental pulp cell that possesses stem-cell-like qualities, including self-renewal capability and multi-lineage differentiation."], "t": []}], "preferred_name": "dental pulp stem cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C4316814", "l": "Pelger Huet cell (cell)", "d": [], "t": []}, {"i": "NCIT:C36721", "l": "Pelger-Huet Cell", "d": [], "t": []}, {"i": "SNOMEDCT:726587004", "l": "", "d": [], "t": []}], "preferred_name": "Pelger Huet cell (cell)", "taxa": []}
{"type": "biolink:Cell", "ic": 90.871710685482, "identifiers": [{"i": "UMLS:C1882052", "l": "Neoplastic Epithelial Small Polygonal Cell", "d": [], "t": []}, {"i": "NCIT:C60993", "l": "Neoplastic Epithelial Small Polygonal Cell", "d": [], "t": []}], "preferred_name": "Neoplastic Epithelial Small Polygonal Cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0524456", "l": "Structure of endocervical glandular cell", "d": [], "t": []}, {"i": "SNOMEDCT:91767003", "l": "", "d": [], "t": []}], "preferred_name": "Structure of endocervical glandular cell", "taxa": []}
{"type": "biolink:Cell", "ic": 81.34422831136257, "identifiers": [{"i": "CL:0000336", "l": "adrenal medulla chromaffin cell", "d": ["A cell found within the adrenal medulla that secrete biogenic amine hormones upon stimulation."], "t": []}, {"i": "UMLS:C1181474", "l": "Chromaffin cell of adrenal medulla", "d": [], "t": []}], "preferred_name": "adrenal medulla chromaffin cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C2330475", "l": "Goblet cell of epithelium of crypt of Lieberkuhn of small intestine", "d": [], "t": []}], "preferred_name": "Goblet cell of epithelium of crypt of Lieberkuhn of small intestine", "taxa": []}
{"type": "biolink:Cell", "ic": 80.61184433509295, "identifiers": [{"i": "CL:0000896", "l": "activated CD4-positive, alpha-beta T cell", "d": ["A recently activated CD4-positive, alpha-beta T cell with the phenotype CD69-positive, CD62L-negative, CD127-negative, and CD25-positive."], "t": []}], "preferred_name": "activated CD4-positive, alpha-beta T cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:1001577", "l": "tonsil squamous cell", "d": ["Squamous cell of tonsil epithelium."], "t": []}], "preferred_name": "tonsil squamous cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5216191", "l": "Basophils|NCnc|Pt|Body fld", "d": [], "t": []}], "preferred_name": "Basophils|NCnc|Pt|Body fld", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4042034", "l": "CGRP-expressing neuron", "d": ["An interneuron neuron characterized by the expression of calcitonin gene-related peptide (CGRP), a 37-amino acid neuropeptide. This neuron type is involved in nociception and pain modulation by facilitating the transmission of nociceptive signals from peripheral sensory nerve endings to central nervous system structures. This neuron type is found in the dorsal root ganglia (DRG) and trigeminal ganglion, and the spinal cord dorsal horn."], "t": []}], "preferred_name": "CGRP-expressing neuron", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5854443", "l": "Autologous Anti-DLL3 CAR-T Cells LB2102", "d": [], "t": []}, {"i": "NCIT:C199628", "l": "Autologous Anti-DLL3 CAR-T Cells LB2102", "d": ["A preparation of autologous T-lymphocytes that have been genetically engineered to express a chimeric antigen receptor (CAR) specific for the tumor-associated antigen (TAA) delta-like protein 3 (DLL3), with potential immunomodulating and antineoplastic activities. Upon administration, autologous anti-DLL3 CAR-T cells LB2102 recognize and induce selective toxicity in DLL3-expressing tumor cells. DLL3, a Notch pathway protein, is overexpressed on a variety of cancer cell types. It plays a key role in embryonic development and in tumor initiation and proliferation."], "t": []}], "preferred_name": "Autologous Anti-DLL3 CAR-T Cells LB2102", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5907929", "l": "Autologous Anti-CLDN18.2 TAC T-cells TAC01-CLDN18.2", "d": [], "t": []}, {"i": "NCIT:C201811", "l": "Autologous Anti-CLDN18.2 TAC T-cells TAC01-CLDN18.2", "d": ["A preparation of autologous T-lymphocytes that have been genetically engineered to express a T-cell Antigen Coupler (TAC), comprised of a domain that targets the tumor-associated antigen (TAA) claudin 18.2 (CLDN18.2; A2 isoform of claudin-18) and another domain that binds to the endogenous T-cell receptor (TCR), with potential immunostimulating and antineoplastic activities. Upon administration, autologous anti-CLDN18.2 TAC T-cells TAC01-CLDN18.2 target and bind to CLDN18.2-expressing tumor cells and activate TCR-mediated signaling pathways, leading to T-cell-mediated killing of CLDN18.2-expressing tumor cells. CLDN18.2, a tight junction protein and stomach-specific isoform of claudin-18, is expressed on a variety of tumor cells. Its expression in healthy tissues is strictly confined to short-lived differentiated epithelial cells of the gastric mucosa."], "t": []}], "preferred_name": "Autologous Anti-CLDN18.2 TAC T-cells TAC01-CLDN18.2", "taxa": []}
{"type": "biolink:Cell", "ic": 79.9528279018387, "identifiers": [{"i": "CL:0000171", "l": "pancreatic A cell", "d": ["A type A enteroendocrine cell found in the periphery of the islets of Langerhans that secretes glucagon."], "t": []}], "preferred_name": "pancreatic A cell", "taxa": []}
{"type": "biolink:Cell", "ic": 76.78008365410358, "identifiers": [{"i": "UMLS:C1708902", "l": "Malignant Polygonal Cell with Eosinophilic Cytoplasm", "d": [], "t": []}, {"i": "NCIT:C53641", "l": "Malignant Polygonal Cell with Eosinophilic Cytoplasm", "d": [], "t": []}], "preferred_name": "Malignant Polygonal Cell with Eosinophilic Cytoplasm", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5982792", "l": "revakinagene taroretcel-lwey", "d": [], "t": []}], "preferred_name": "revakinagene taroretcel-lwey", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4047030", "l": "pre-venule capillary cell", "d": ["A specialized endothelial cell located in the transition zone between capillaries and small venules in the microvascular system. It exhibits characteristics of both capillary and venous cells, expressing markers from both types. This cell plays a role in regulating blood flow and substance exchange between blood and tissues."], "t": []}], "preferred_name": "pre-venule capillary cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5214313", "l": "Villous lymphocytes | Blood | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Villous lymphocytes | Blood | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0020048", "l": "secretomotor/vasodilator neuron of myenteric plexus", "d": ["An enteric neuron whose soma resides in the myenteric plexus and which controls mucosal secretion and blood flow by innervating secretory epithelia and submucosal blood vessels. This neuron is characterised by expression of vasoactive intestinal peptide (VIP). In mouse, two Glp2r+ subtypes have been identified: PSVN1 (VIP+, non-cholinergic) and PSVN2 (ChAT+, cholinergic). In human, only the VIP+ non-cholinergic subtype has been detected."], "t": []}], "preferred_name": "secretomotor/vasodilator neuron of myenteric plexus", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4511887", "l": "Population of all epithelial cells in portion of fluid", "d": [], "t": []}, {"i": "SNOMEDCT:726504009", "l": "", "d": [], "t": []}], "preferred_name": "Population of all epithelial cells in portion of fluid", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5555595", "l": "Allogeneic Anti-CD19 CAR T-cells PBCAR19B", "d": [], "t": []}, {"i": "NCIT:C179301", "l": "Allogeneic Anti-CD19 CAR T-cells PBCAR19B", "d": ["A preparation of allogeneic T-lymphocytes that have been genetically modified to express a chimeric antigen receptor (CAR) targeting the tumor-associated antigen (TAA) CD19 (cluster of differentiation 19), a single short hairpin RNA (shRNA) that disrupts the expression of beta-2 microglobulin (B2M) component of the class 1 major histocompatibility complex (MHC) molecules, and a HLA-E gene, with potential immunostimulating and antineoplastic activities. Upon administration, the allogeneic anti-CD19 CAR T-cells PBCAR19B specifically recognize and bind to CD19-expressing tumor cells. This may result in a specific cytotoxic T-lymphocyte (CTL)-mediated killing of CD19-expressing tumor cells. The downregulation of the expression of the class 1 MHC molecule component B2M by shRNA and the HLA-E gene decrease the number of CAR T-cells that are rejected and killed by natural killer (NK) and cytotoxic T-cells. CD19 antigen is a B-cell specific cell surface antigen overexpressed in B-cell lineage malignancies."], "t": []}], "preferred_name": "Allogeneic Anti-CD19 CAR T-cells PBCAR19B", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C2330901", "l": "Set of granulocytes", "d": [], "t": []}], "preferred_name": "Set of granulocytes", "taxa": []}
{"type": "biolink:Cell", "ic": 90.871710685482, "identifiers": [{"i": "CL:1000682", "l": "kidney medulla interstitial cell", "d": ["A cell that is part of an interstitum of a renal medulla."], "t": []}], "preferred_name": "kidney medulla interstitial cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0222619", "l": "Structure of granular polyhedral cells of breast", "d": [], "t": []}, {"i": "SNOMEDCT:15192008", "l": "", "d": [], "t": []}], "preferred_name": "Structure of granular polyhedral cells of breast", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1979124", "l": "Blasts.CD126", "d": [], "t": []}], "preferred_name": "Blasts.CD126", "taxa": []}
{"type": "biolink:Cell", "ic": 89.40238429118027, "identifiers": [{"i": "UMLS:C1514042", "l": "Neoplastic Natural Killer Cell", "d": [], "t": []}, {"i": "NCIT:C36994", "l": "Neoplastic Natural Killer Cell", "d": [], "t": []}], "preferred_name": "Neoplastic Natural Killer Cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5575850", "l": "Autologous CD19/CD22 Chimeric Antigen Receptor T-cells CT120", "d": [], "t": []}], "preferred_name": "Autologous CD19/CD22 Chimeric Antigen Receptor T-cells CT120", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1518223", "l": "Malignant Neuroendocrine Small Cell with Round Nucleus", "d": [], "t": []}, {"i": "NCIT:C36853", "l": "Malignant Neuroendocrine Small Cell with Round Nucleus", "d": [], "t": []}], "preferred_name": "Malignant Neuroendocrine Small Cell with Round Nucleus", "taxa": []}
{"type": "biolink:Cell", "ic": 54.62762067996328, "identifiers": [{"i": "CL:0002092", "l": "bone marrow cell", "d": ["A cell found in the bone marrow. This can include fibroblasts, macrophages, adipocytes, osteoblasts, osteoclasts, endothelial cells and hematopoietic cells."], "t": []}, {"i": "UMLS:C0005955", "l": "Bone Marrow Cells", "d": [], "t": []}, {"i": "MESH:D001854", "l": "Bone Marrow Cells", "d": [], "t": []}], "preferred_name": "bone marrow cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5784969", "l": "CD40L-augmented Autologous Tumor Infiltrating Lymphocytes", "d": [], "t": []}, {"i": "NCIT:C192191", "l": "CD40L-augmented Autologous Tumor Infiltrating Lymphocytes", "d": ["A preparation of autologous tumor-infiltrating lymphocytes (TILs) derived from a patient's tumor that have been stimulated ex vivo with CD40 ligand (CD40L, tumor necrosis factor superfamily member 5, TNFSF5, CD154, TNF-related activation protein, TRAP, gp39) during cell expansion, with potential immunomodulating and antineoplastic activities. Upon administration, the CD40L-augmented autologous TILs specifically recognize and kill the patient's tumor cells. Stimulation with a CD40L may enhance both the expansion of the TILs and the tumor-killing ability of the TILs when returned to the patient."], "t": []}], "preferred_name": "CD40L-augmented Autologous Tumor Infiltrating Lymphocytes", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:2000064", "l": "ovarian surface epithelial cell", "d": ["A meso-epithelial cell of the ovarian surface epithelium, varying in shape from flat to cuboidal to pseudostratified columnar. This cell plays a crucial role in ovulation by producing proteolytic enzymes in response to gonadotropins, facilitating follicle rupture through tissue breakdown and TNF-alpha signaling. Additionally, this cell contributes to post-ovulatory wound repair (Morris et al., 2022) and exhibits stem cell-like properties (Flesken-Nikitin et al., 2013; Wang et al., 2019)."], "t": []}], "preferred_name": "ovarian surface epithelial cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C3176884", "l": "Blasts.cytoplasmic CD117", "d": [], "t": []}], "preferred_name": "Blasts.cytoplasmic CD117", "taxa": []}
{"type": "biolink:Cell", "ic": 90.871710685482, "identifiers": [{"i": "CL:0002343", "l": "decidual natural killer cell, human", "d": ["A natural killer cell subset that is found in the decidual of the uterus and is CD56-high, Galectin-1-positive and CD16-negative. This cell type represents the most abundant immune cell type in the decidual during the first trimester of pregnancy."], "t": []}], "preferred_name": "decidual natural killer cell, human", "taxa": []}
{"type": "biolink:Cell", "ic": 77.38833137893549, "identifiers": [{"i": "UMLS:C1709198", "l": "Neoplastic Sebocyte", "d": [], "t": []}, {"i": "NCIT:C43338", "l": "Neoplastic Sebocyte", "d": [], "t": []}], "preferred_name": "Neoplastic Sebocyte", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5163557", "l": "Epithelial cells.squamous | Urine | Urinalysis", "d": [], "t": []}], "preferred_name": "Epithelial cells.squamous | Urine | Urinalysis", "taxa": []}
{"type": "biolink:Cell", "ic": 71.93166454101878, "identifiers": [{"i": "UMLS:C0225369", "l": "Chondrocyte", "d": [], "t": []}, {"i": "NCIT:C12557", "l": "Chondrocyte", "d": ["A cell arising from mesenchymal stem cells that produces and is surrounded by the extracellular matrix of cartilage."], "t": []}, {"i": "MESH:D019902", "l": "Chondrocytes", "d": [], "t": []}, {"i": "SNOMEDCT:433180002", "l": "", "d": [], "t": []}, {"i": "SNOMEDCT:81272008", "l": "", "d": [], "t": []}], "preferred_name": "Chondrocyte", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5216235", "l": "Leukocytes|NCnc|Pt|Dial fld prt", "d": [], "t": []}], "preferred_name": "Leukocytes|NCnc|Pt|Dial fld prt", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5691293", "l": "Intestinal Villous M Cells", "d": [], "t": []}], "preferred_name": "Intestinal Villous M Cells", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1267852", "l": "Lymphocyte positive for CD7 antigen", "d": [], "t": []}, {"i": "SNOMEDCT:117538001", "l": "", "d": [], "t": []}], "preferred_name": "Lymphocyte positive for CD7 antigen", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C4724851", "l": "Allogeneic TCR alpha/beta-positive T-lymphocyte-depleted Peripheral Blood Stem Cells", "d": [], "t": []}, {"i": "NCIT:C148149", "l": "Allogeneic TCR alpha/beta-positive T-lymphocyte-depleted Peripheral Blood Stem Cells", "d": ["A preparation of allogeneic T-cell receptor (TCR) alpha/beta-positive T cell-depleted peripheral blood stem cells (PBSCs), that can potentially be used for hematopoietic stem cell transplantation (HSCT). Allogeneic PBMCs are processed, using the proprietary CliniMACS device, to remove TCRalpha/beta T-cells, while retaining other cells, such as donor-derived natural killer (NK) cells and gamma/delta T-cells. As TCR alpha/beta-positive T-cells appear to be related to the development of graft versus host disease (GvHD), depletion of these cells may lower the risk of the recipient developing GvHD. Upon infusion of the TCR alpha/beta-positive T-cell-depleted PBSCs for allogeneic stem cell transplantation (allo SCT), the alpha/beta-positive T-cell depletion as well as the presence of allogeneic NK cells, and other cells, may facilitate engraftment, exert graft-versus-leukemia effects, enhance post-transplant immune recovery, and reduce the risk of infections and GvHD."], "t": []}], "preferred_name": "Allogeneic TCR alpha/beta-positive T-lymphocyte-depleted Peripheral Blood Stem Cells", "taxa": []}
{"type": "biolink:Cell", "ic": 85.53200374075534, "identifiers": [{"i": "CL:0000096", "l": "mature neutrophil", "d": ["A fully differentiated neutrophil, a granular leukocyte having a nucleus with three to five lobes connected by slender threads, and cytoplasm containing fine inconspicuous granules and stainable by neutral dyes. They are produced in bone marrow at a rate of 5e10-10e10/day and have a half-life of 6-8 hours. Neutrophils are CD15-positive, CD16-positive, CD32-positive, CD43-positive, CD181-positive, and CD182-positive."], "t": []}], "preferred_name": "mature neutrophil", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1267819", "l": "Lymphocyte positive for both CD3 antigen and CD26 antigen", "d": [], "t": []}, {"i": "SNOMEDCT:117520004", "l": "", "d": [], "t": []}], "preferred_name": "Lymphocyte positive for both CD3 antigen and CD26 antigen", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5175161", "l": "Nucleated erythrocytes | Synovial fluid | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Nucleated erythrocytes | Synovial fluid | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0002583", "l": "subcutaneous preadipocyte", "d": ["A preadipocyte that is part of subcutaneous tissue."], "t": []}], "preferred_name": "subcutaneous preadipocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 85.53200374075534, "identifiers": [{"i": "UMLS:C5856642", "l": "Anti-EGFR CAR T Cells Preparation", "d": [], "t": []}, {"i": "NCIT:C201175", "l": "Anti-EGFR CAR T Cells Preparation", "d": ["Any preparation of chimeric antigen receptor (CAR) expressing T-lymphocytes that targets the tumor-associated antigen (TAA) epidermal growth factor receptor (EGFR)."], "t": []}], "preferred_name": "Anti-EGFR CAR T Cells Preparation", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0002458", "l": "langerin-positive dermal dendritic cell", "d": ["A dermal dendritic cell that is langerin-positive and CD103-positive."], "t": []}], "preferred_name": "langerin-positive dermal dendritic cell", "taxa": []}
{"type": "biolink:Cell", "ic": 53.31419182370224, "identifiers": [{"i": "UMLS:C1519004", "l": "Peripheral (Post-Thymic) T-Lymphocyte", "d": [], "t": []}, {"i": "NCIT:C38434", "l": "Peripheral (Post-Thymic) T-Lymphocyte", "d": [], "t": []}], "preferred_name": "Peripheral (Post-Thymic) T-Lymphocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C4524565", "l": "Hematopoietic Progenitor Cells from Apheresis", "d": [], "t": []}, {"i": "NCIT:C133328", "l": "Hematopoietic Progenitor Cells from Apheresis", "d": ["Peripheral blood collected by apheresis as a source of hematopoietic progenitor cells."], "t": []}], "preferred_name": "Hematopoietic Progenitor Cells from Apheresis", "taxa": []}
{"type": "biolink:Cell", "ic": 88.20185721311867, "identifiers": [{"i": "CL:0000783", "l": "multinucleated phagocyte", "d": ["A phagocyte formed by the fusion of mononuclear phagocytes."], "t": []}], "preferred_name": "multinucleated phagocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C4085987", "l": "Anti-mesothelin CAR Vector-transduced Autologous T-lymphocytes", "d": [], "t": []}, {"i": "NCIT:C124650", "l": "Anti-mesothelin CAR Vector-transduced Autologous T-lymphocytes", "d": ["Genetically modified, autologous T-lymphocytes transduced with a retroviral vector encoding a chimeric antigen receptor (CAR) consisting of an anti-human tumor-associated antigen (TAA) mesothelin single chain variable fragment (scFv), the intracellular CD3 zeta T-cell receptor domain and the 4-1BB (cd137) costimulatory domain, with potential immunomodulating and antineoplastic activities. After isolation, transduction, expansion in culture, and reintroduction into the patient, the anti-mesothelin CAR vector-transduced autologous T-lymphocytes specifically target and kill mesothelin-expressing tumor cells. Mesothelin, a cell surface glycoprotein involved in cell adhesion, is overexpressed in a variety of cancer cell types."], "t": []}], "preferred_name": "Anti-mesothelin CAR Vector-transduced Autologous T-lymphocytes", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1717663", "l": "CD20+FMC7+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:1373101004", "l": "", "d": [], "t": []}], "preferred_name": "CD20+FMC7+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1267848", "l": "Lymphocyte positive for both CD5 antigen and CD25 antigen", "d": [], "t": []}, {"i": "SNOMEDCT:116818000", "l": "", "d": [], "t": []}], "preferred_name": "Lymphocyte positive for both CD5 antigen and CD25 antigen", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5960001", "l": "Allogeneic TCR-CD3 complex/CD16/IL-15-expressing Natural Killer Cells", "d": [], "t": []}, {"i": "NCIT:C206683", "l": "Allogeneic TCR-CD3 complex/CD16/IL-15-expressing Natural Killer Cells", "d": ["A preparation of allogeneic natural killer (NK) cells that have been engineered to express a T-cell receptor (TCR)-CD3 complex, CD16 Fc receptor, and interleukin 15 (IL-15), with potential immunostimulating and antineoplastic activities. Upon administration, allogeneic TCR-CD3 complex/CD16/IL-15-expressing NK cells lyse tumor cells. Upon coadministration with tumor-targeting and CD3-targeting bispecific antibodies, the tumor-targeting moiety binds to the tumor-associated antigens (TAAs) expressed on tumor cells and the anti-CD3 moiety binds to the TCR-CD3 complex expressed on the allogeneic NK cells. This may enhance NK cell-mediated lysis of the TAA-expressing tumor cells. Upon coadministration with certain tumor-targeting monoclonal antibodies, the Fab moiety of the antibodies binds to the TAAs expressed on tumor cells and the Fc moiety of the antibodies binds to CD16 expressed on the allogeneic NK cells. This leads to antibody-dependent cellular cytotoxicity (ADCC) of the antibody-bound tumor cells. CD16, also known as Fc-gamma receptor III, is normally expressed on the surface of NK cells, neutrophils, monocytes and macrophages, and plays a key role in initiating ADCC. It is often downregulated in certain cancers, thereby inhibiting the anti-tumor immune response. IL-15 promotes the survival of NK cells and enhances the cytotoxic effect of NK cells and activated anti-tumor T-cells."], "t": []}], "preferred_name": "Allogeneic TCR-CD3 complex/CD16/IL-15-expressing Natural Killer Cells", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5545270", "l": "Virtual Memory T Cells", "d": [], "t": []}], "preferred_name": "Virtual Memory T Cells", "taxa": []}
{"type": "biolink:Cell", "ic": 87.18682603146104, "identifiers": [{"i": "UMLS:C1711302", "l": "Malignant Parathyroid Gland Oncocyte", "d": [], "t": []}, {"i": "NCIT:C48273", "l": "Malignant Parathyroid Gland Oncocyte", "d": [], "t": []}], "preferred_name": "Malignant Parathyroid Gland Oncocyte", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1861193", "l": "THROMBOCYTE B", "d": [], "t": []}], "preferred_name": "THROMBOCYTE B", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0000956", "l": "pre-B-I cell", "d": ["A pre-B-I cell is a precursor B cell that expresses CD34 and surrogate immunoglobulin light chain (VpreB , Lambda 5 (mouse)/14.1 (human)) on the cell surface, and TdT, Rag1,and Rag2 intracellularly. Cell type carries a D-JH DNA rearrangement, and lacks expression of immunglobulin heavy chain protein."], "t": []}], "preferred_name": "pre-B-I cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0945934", "l": "CD8+CD11b+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:1373048004", "l": "", "d": [], "t": []}], "preferred_name": "CD8+CD11b+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5220592", "l": "Histiocytes|Urine/Urine sed", "d": [], "t": []}], "preferred_name": "Histiocytes|Urine/Urine sed", "taxa": []}
{"type": "biolink:Cell", "ic": 46.80043091380106, "identifiers": [{"i": "CL:0000048", "l": "multi fate stem cell", "d": ["A stem cell that can give rise to multiple lineages of cells."], "t": []}, {"i": "UMLS:C1136335", "l": "Multipotent Stem Cells", "d": [], "t": []}, {"i": "NCIT:C43419", "l": "Multipotent Stem Cell", "d": ["A cell that can only differentiate to a particular type of cells (e.g. hematopoietic cells or epithelial cells). --2005"], "t": []}, {"i": "MESH:D039902", "l": "Multipotent Stem Cells", "d": [], "t": []}], "preferred_name": "multi fate stem cell", "taxa": []}
{"type": "biolink:Cell", "ic": 71.22863277767533, "identifiers": [{"i": "CL:0000065", "l": "ependymal cell", "d": ["A neuroepithelial glial cell, derived from a radial glial cell originating from the neuroectoderm, lines the ventricles of the brain and the central canal of the spinal cord. This cell is characterized by the presence of cilia on its apical surface, which can be motile or non-motile."], "t": []}, {"i": "UMLS:C0228092", "l": "Ependymal cell", "d": [], "t": []}, {"i": "NCIT:C13003", "l": "Ependymal Cell", "d": ["A cell that lines cavities in the central nervous system.  It is considered to be a type of glial cell."], "t": []}, {"i": "SNOMEDCT:46940003", "l": "", "d": [], "t": []}], "preferred_name": "ependymal cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0546497", "l": "P.B. plasmoblast", "d": [], "t": []}], "preferred_name": "P.B. plasmoblast", "taxa": []}
{"type": "biolink:Cell", "ic": 92.76600187037766, "identifiers": [{"i": "UMLS:C0682649", "l": "Proprioceptor", "d": [], "t": []}, {"i": "NCIT:C13823", "l": "Proprioceptor", "d": ["A primary sensory neuron that acts as a receptor of the somatic afferent component of the nervous system. It is stimulated by the contraction of muscles, movements of joints, and changes in body position."], "t": []}], "preferred_name": "Proprioceptor", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0444746", "l": "Endocyte", "d": [], "t": []}, {"i": "SNOMEDCT:262506003", "l": "", "d": [], "t": []}], "preferred_name": "Endocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 78.29800561113302, "identifiers": [{"i": "CL:0000801", "l": "gamma-delta intraepithelial T cell", "d": ["A mature gamma-delta T cell that is found in the columnar epithelium of the gastrointestinal tract. These cells participate in mucosal immune responses."], "t": []}], "preferred_name": "gamma-delta intraepithelial T cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4304490", "l": "Population of all blast cells in portion of fluid", "d": [], "t": []}, {"i": "SNOMEDCT:719698008", "l": "", "d": [], "t": []}], "preferred_name": "Population of all blast cells in portion of fluid", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5181132", "l": "Smudge cells | Blood | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Smudge cells | Blood | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "CL:0002041", "l": "immature NK T cell stage III, mouse", "d": ["A CD24-low, CD44-positive, DX5-low, NK1.1-negative NK T cell."], "t": []}], "preferred_name": "immature NK T cell stage III, mouse", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5708042", "l": "Anti-PSMA/Anti-CD70 4SCAR-expressing Bispecific T-cells", "d": [], "t": []}, {"i": "NCIT:C188802", "l": "Anti-PSMA/Anti-CD70 4SCAR-expressing Bispecific T-cells", "d": ["A preparation of T-lymphocytes that are genetically engineered to express a fourth-generation chimeric antigen receptor (4SCAR) targeting the two tumor-associated antigens (TAAs) prostate-specific membrane antigen (PSMA) and CD70 (CD27 ligand; tumor necrosis factor superfamily member 7; TNFSF7), with potential immunostimulating and antineoplastic activities. Upon administration, the anti-PSMA/anti-CD70 4SCAR-expressing bispecific T-cells are directed to and induce selective toxicity in PSMA- and CD70-expressing tumor cells. PSMA, a type II transmembrane protein, is expressed on the membrane of prostatic epithelial cells and overexpressed on prostate tumor cells as well as a variety of other solid tumors, including brain tumor, neuroblastoma and some lymphoma tumor tissues. CD70, a cytokine belonging to the tumor necrosis superfamily (TNFSF) and the ligand for the costimulatory receptor CD27, is expressed on the surfaces of various types of cancer cells; its overexpression may play an important role in the evasion of immune surveillance."], "t": []}], "preferred_name": "Anti-PSMA/Anti-CD70 4SCAR-expressing Bispecific T-cells", "taxa": []}
{"type": "biolink:Cell", "ic": 73.26332733876373, "identifiers": [{"i": "UMLS:C5856883", "l": "Therapeutic Tumor Infiltrating Lymphocytes Preparation", "d": [], "t": []}, {"i": "NCIT:C201547", "l": "Therapeutic Tumor Infiltrating Lymphocytes Preparation", "d": ["A preparation of tumor infiltrating lymphocytes (TILs)."], "t": []}], "preferred_name": "Therapeutic Tumor Infiltrating Lymphocytes Preparation", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:1000365", "l": "transitional myocyte of atrial septal branch of anterior internodal tract", "d": ["A transitional myocyte that is part of the atrial septal branch of anterior internodal tract."], "t": []}, {"i": "UMLS:C2337273", "l": "Transitional myocyte of atrial septal branch of anterior internodal tract", "d": [], "t": []}], "preferred_name": "transitional myocyte of atrial septal branch of anterior internodal tract", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0312866", "l": "Sensitized leukocyte", "d": [], "t": []}, {"i": "SNOMEDCT:64668006", "l": "", "d": [], "t": []}], "preferred_name": "Sensitized leukocyte", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5171660", "l": "Lymphocytes | Cerebral spinal fluid | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Lymphocytes | Cerebral spinal fluid | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0002247", "l": "pleural macrophage", "d": ["A tissue macrophage that is in the pleural space."], "t": []}, {"i": "UMLS:C2336257", "l": "Pleural macrophage", "d": [], "t": []}], "preferred_name": "pleural macrophage", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4033170", "l": "pelvic ganglion nNOS neuron", "d": ["A parasympathetic neuron that has the soma located in the pelvic ganglion and expresses the marker neuronal nitric oxide synthase 1 (nNOS)."], "t": []}], "preferred_name": "pelvic ganglion nNOS neuron", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5157598", "l": "CD5+CD20+ cells | Blood | Cell markers", "d": [], "t": []}], "preferred_name": "CD5+CD20+ cells | Blood | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": 92.76600187037766, "identifiers": [{"i": "CL:4301602", "l": "Tanycyte NN_1 tanycyte (Mmus)", "d": ["A tanycyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Cnmd (Mmus), Lpl (Mmus). Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Supertype:1172 Tanycyte NN_1."], "t": []}], "preferred_name": "Tanycyte NN_1 tanycyte (Mmus)", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5157556", "l": "CD4+CD8+ | White blood cells | Cell markers", "d": [], "t": []}], "preferred_name": "CD4+CD8+ | White blood cells | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0009038", "l": "colon macrophage", "d": ["A macrophage that is located in the colon."], "t": []}], "preferred_name": "colon macrophage", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C6022152", "l": "Cells.CD3-CD19+ | Blood | Cell markers", "d": [], "t": []}], "preferred_name": "Cells.CD3-CD19+ | Blood | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": 53.54878499100308, "identifiers": [{"i": "CL:0000163", "l": "endocrine cell", "d": ["A cell of an endocrine gland, ductless glands that secrete substances which are released directly into the circulation and which influence metabolism and other body functions."], "t": []}, {"i": "UMLS:C0229525", "l": "Endocrine Cells", "d": [], "t": []}, {"i": "NCIT:C32506", "l": "Endocrine Cell", "d": [], "t": []}, {"i": "MESH:D055098", "l": "Endocrine Cells", "d": [], "t": []}, {"i": "SNOMEDCT:68233007", "l": "", "d": [], "t": []}], "preferred_name": "endocrine cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0002007", "l": "Kit-low, CD34-positive eosinophil progenitor cell", "d": ["A lineage marker-negative, CD34-positive, IL5r-alpha-positive, and Sca1-negative eosinophil progenitor cell."], "t": []}], "preferred_name": "Kit-low, CD34-positive eosinophil progenitor cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:1001214", "l": "arcuate artery smooth muscle cell", "d": ["Any smooth muscle cell that is part of some kidney arcuate artery."], "t": []}], "preferred_name": "arcuate artery smooth muscle cell", "taxa": []}
{"type": "biolink:Cell", "ic": 86.30756602822301, "identifiers": [{"i": "CL:0000632", "l": "hepatic stellate cell", "d": ["A cell that is found in the perisinusoidal space of the liver that is capable of multiple roles including storage of retinol, presentation of antigen to T cells (including CD1d-restricted NKT cells), and upon activation, production of extracellular matrix components that can contribute to liver fibrosis. This activated state has a myofibroblast-like phenotype, though it's not clear in the literature if this is terminally differentiated. This cell type comprises approximately 8-15% of total cells in the liver."], "t": []}, {"i": "UMLS:C0227531", "l": "Ito Cells", "d": [], "t": []}, {"i": "SNOMEDCT:39977009", "l": "", "d": [], "t": []}], "preferred_name": "hepatic stellate cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0002515", "l": "interrenal norepinephrine type cell", "d": ["An interrenal chromaffin cell found in teleosts that contain heterogeneous vesicles with electron-dense granules located asymmetrically within the vesicular membrane."], "t": []}], "preferred_name": "interrenal norepinephrine type cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5170959", "l": "Leukocytes other | Vitreous fluid | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Leukocytes other | Vitreous fluid | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C2736938", "l": "CD8+CD45RO+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:1373053009", "l": "", "d": [], "t": []}], "preferred_name": "CD8+CD45RO+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": 67.8984399852903, "identifiers": [{"i": "CL:0000040", "l": "monoblast", "d": ["A myeloid progenitor cell committed to the monocyte lineage. This cell is CD11b-positive, has basophilic cytoplasm, euchromatin, and the presence of a nucleolus."], "t": []}], "preferred_name": "monoblast", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4296891", "l": "L cell, Glucagon-like peptide-producing and PP/PYY-producing NETs", "d": [], "t": []}], "preferred_name": "L cell, Glucagon-like peptide-producing and PP/PYY-producing NETs", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C3496265", "l": "B2 cell group", "d": [], "t": []}], "preferred_name": "B2 cell group", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4307029", "l": "Astro-NT NN_1 Slc36a2 astrocyte (Mmus)", "d": ["A astrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Gfap (Mmus), Slc36a2 (Mmus), Sfrp5 (Mmus). It is distinguished from other Astro-NT NN_1 cells by expression of Slc36a2, Sfrp5. These cells are located in the Midbrain, Cerebellum, brain . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5209 Astro-NT NN_1."], "t": []}], "preferred_name": "Astro-NT NN_1 Slc36a2 astrocyte (Mmus)", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5157505", "l": "CD36 blasts | Bone marrow | Cell markers", "d": [], "t": []}], "preferred_name": "CD36 blasts | Bone marrow | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": 79.64650900338474, "identifiers": [{"i": "CL:1000410", "l": "myocyte of atrioventricular node", "d": ["A muscle cell that is part of the atrioventricular node."], "t": []}, {"i": "UMLS:C1179873", "l": "Myocyte of atrioventricular node", "d": [], "t": []}], "preferred_name": "myocyte of atrioventricular node", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5216320", "l": "Smudge cells|NCnc|Pt|Bld", "d": [], "t": []}], "preferred_name": "Smudge cells|NCnc|Pt|Bld", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4310095", "l": "GPi Core neuron (Primate)", "d": ["A internal globus pallidus core projecting neuron of the Primates brain. These cells are located in the internal segment of globus pallidus . Reference transcriptomic data for this type can be found in the dataset/taxonomy - HMBA Basal Ganglia Consensus Taxonomy in cell set Group:GPi Core."], "t": []}], "preferred_name": "GPi Core neuron (Primate)", "taxa": []}
{"type": "biolink:Cell", "ic": 90.871710685482, "identifiers": [{"i": "CL:0000796", "l": "CD8-alpha-beta-positive, alpha-beta intraepithelial T cell", "d": ["A alpha-beta intraepithelial T cell found in the columnar epithelium of the gastrointestinal tract. Intraepithelial T cells often have distinct developmental pathways and activation requirements."], "t": []}], "preferred_name": "CD8-alpha-beta-positive, alpha-beta intraepithelial T cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C6070747", "l": "Leptocytes | Blood | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Leptocytes | Blood | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": 89.40238429118027, "identifiers": [{"i": "CL:4052018", "l": "fallopian tube epithelial cell", "d": ["Any epithelial cell that is part of the fallopian tube."], "t": []}], "preferred_name": "fallopian tube epithelial cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1527294", "l": "GE07 cell line", "d": [], "t": []}, {"i": "NCIT:C20257", "l": "GE07", "d": ["Provider: Geron Corporation, Menlo Park, CA. No information from provider. This cell line meets the criteria for the use of human embryonic stem cells by federally funded researchers."], "t": []}], "preferred_name": "GE07 cell line", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5216206", "l": "Erythrocytes.nucleated|NCnc|Pt|Bld", "d": [], "t": []}], "preferred_name": "Erythrocytes.nucleated|NCnc|Pt|Bld", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0004162", "l": "360 nm-cone", "d": ["A cone whose sensitivity measurements have an average spectral peak of 358.2 nm. These cones are described in rat."], "t": []}], "preferred_name": "360 nm-cone", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5185787", "l": "ZAP70 cells | XXX | Cell markers", "d": [], "t": []}], "preferred_name": "ZAP70 cells | XXX | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0598088", "l": "continuous cell line", "d": [], "t": []}], "preferred_name": "continuous cell line", "taxa": []}
{"type": "biolink:Cell", "ic": 65.66137489470532, "identifiers": [{"i": "UMLS:C3811668", "l": "Circulating Plasma Cell", "d": [], "t": []}, {"i": "NCIT:C114278", "l": "Circulating Plasma Cell", "d": ["A plasma cell myeloma-derived cell found in the peripheral blood."], "t": []}], "preferred_name": "Circulating Plasma Cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5381002", "l": "Cells.CD8.HLA-A2 CMV specific", "d": [], "t": []}], "preferred_name": "Cells.CD8.HLA-A2 CMV specific", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1440421", "l": "TCR alpha beta+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:1376054009", "l": "", "d": [], "t": []}], "preferred_name": "TCR alpha beta+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": 88.20185721311867, "identifiers": [{"i": "UMLS:C1518353", "l": "Malignant Non-Cutaneous Basaloid Cell", "d": [], "t": []}, {"i": "NCIT:C36783", "l": "Malignant Non-Cutaneous Basaloid Cell", "d": [], "t": []}], "preferred_name": "Malignant Non-Cutaneous Basaloid Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1513814", "l": "NC01", "d": [], "t": []}, {"i": "NCIT:C20281", "l": "NC01", "d": ["Provider: National Centre for Biological Sciences/ Tata Institute of Fundamental Research, Bangalore, India. No information from provider. This cell line meets the criteria for the use of human embryonic stem cells by federally funded researchers."], "t": []}], "preferred_name": "NC01", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1268458", "l": "CD43+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:116833008", "l": "", "d": [], "t": []}], "preferred_name": "CD43+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": 64.39556439996649, "identifiers": [{"i": "UMLS:C1709177", "l": "Neoplastic Granulocyte", "d": [], "t": []}, {"i": "NCIT:C43230", "l": "Neoplastic Granulocyte", "d": [], "t": []}], "preferred_name": "Neoplastic Granulocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5785375", "l": "Anti-CD7 CAR T Cells BT-007", "d": [], "t": []}, {"i": "NCIT:C192687", "l": "Anti-CD7 CAR T Cells BT-007", "d": ["A preparation of T-lymphocytes that have been  genetically engineered and transduced with a lentiviral vector to express a chimeric antigen receptor (CAR) directed against the tumor-associated antigen (TAA) CD7, the co-immunostimulatory signaling domain 4-1BB (CD137) and the intracellular CD3 zeta domain (CD3z), with potential immunostimulating and antineoplastic activities. Upon administration, the anti-CD7 CAR T cells BT-007 specifically recognize and bind to CD7-expressing tumor cells, resulting in specific T-cell-mediated tumor cell lysis. CD7 is a transmembrane glycoprotein expressed by T-cells and natural killer (NK) cells and their precursors. It is expressed in the majority of lymphoblastic T-cell leukemias and lymphomas and in a subset of peripheral T-cell lymphomas."], "t": []}], "preferred_name": "Anti-CD7 CAR T Cells BT-007", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0011018", "l": "lymphoid tissue–inducer cell", "d": ["A group 3 innate lymphoid cell that express ROR gamma t and IL-7R alpha in the absence of lineage markers (e.g. CD3, CD19, B220, CD11c, Gr-1), with the functional ability to interact with mesenchymal cells through lymphotoxin and tumor necrosis factor. Lymphoid tissue-inducer cells are key to the development of lymph nodes and Peyer’s patches."], "t": []}], "preferred_name": "lymphoid tissue–inducer cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5186810", "l": "Metamyelocytes | Fetus | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Metamyelocytes | Fetus | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": 66.41906832761713, "identifiers": [{"i": "UMLS:C1708909", "l": "Malignant Smooth Muscle Cell", "d": [], "t": []}, {"i": "NCIT:C49124", "l": "Malignant Smooth Muscle Cell", "d": ["A malignant mesenchymal cell that originates from a smooth muscle cell."], "t": []}], "preferred_name": "Malignant Smooth Muscle Cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4722559", "l": "NKCARCD19", "d": [], "t": []}], "preferred_name": "NKCARCD19", "taxa": []}
{"type": "biolink:Cell", "ic": 73.15076615569336, "identifiers": [{"i": "UMLS:C1265916", "l": "Abnormal macrophage", "d": [], "t": []}, {"i": "NCIT:C36832", "l": "Abnormal Macrophage", "d": [], "t": []}, {"i": "SNOMEDCT:127565009", "l": "", "d": [], "t": []}], "preferred_name": "Abnormal macrophage", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0882818", "l": "Cell positive for CD20 antigen", "d": [], "t": []}, {"i": "SNOMEDCT:116754005", "l": "", "d": [], "t": []}], "preferred_name": "Cell positive for CD20 antigen", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C3640295", "l": "Allogeneic GM-CSF-secreting Tumor Vaccine PANC 6.03 pcDNA-1/GM-Neo", "d": [], "t": []}, {"i": "NCIT:C101891", "l": "Allogeneic GM-CSF-secreting Tumor Vaccine PANC 6.03 pcDNA-1/GM-Neo", "d": ["An allogeneic cancer vaccine composed of lethally irradiated, whole pancreatic cancer cells transfected with a plasmid carrying the gene for cytokine granulocyte-macrophage colony-stimulating factor (GM-CSF), with potential immunostimulating and antineoplastic activities. Allogeneic GM-CSF-secreting tumor vaccine PANC 6.03 pcDNA-1/GM-Neo secretes GM-CSF thereby activating dendritic cells, promoting antigen presentation to B- and T-cells, and promoting a cytotoxic T-lymphocyte (CTL) response. This may eventually kill tumor cells. The pancreatic tumor cells are derived from the PANC 6.03 tumor cell line."], "t": []}], "preferred_name": "Allogeneic GM-CSF-secreting Tumor Vaccine PANC 6.03 pcDNA-1/GM-Neo", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "CL:0001016", "l": "immature CD1a-positive Langerhans cell", "d": ["Immature CD1a-positive Langerhans cell is a CD1a-positive Langerhans cell that is CD80-low, CD86-low, and MHCII-low."], "t": []}], "preferred_name": "immature CD1a-positive Langerhans cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5179530", "l": "Reticulocytes.mature | Blood | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Reticulocytes.mature | Blood | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0002237", "l": "luminal epithelial cell of prostatic duct", "d": ["A cell that constitutes the luminal layer of epithelium of prostatic duct."], "t": []}, {"i": "UMLS:C1183899", "l": "Luminal cell of prostatic duct", "d": [], "t": []}], "preferred_name": "luminal epithelial cell of prostatic duct", "taxa": []}
{"type": "biolink:Cell", "ic": 72.11981073685999, "identifiers": [{"i": "UMLS:C1706715", "l": "Adenohypophysial Cell", "d": [], "t": []}, {"i": "NCIT:C45920", "l": "Adenohypophysial Cell", "d": ["One of five types of secreting cells (somatotrophs, lactotrophs, corticotrophs, thyrotrophs, and gonadotrophs) found in the anterior lobe of the pituitary gland."], "t": []}], "preferred_name": "Adenohypophysial Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 84.83823963392128, "identifiers": [{"i": "UMLS:C1520165", "l": "Xanthomatous Astrocyte", "d": [], "t": []}, {"i": "NCIT:C37139", "l": "Xanthomatous Astrocyte", "d": [], "t": []}], "preferred_name": "Xanthomatous Astrocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1511006", "l": "BG01", "d": [], "t": []}, {"i": "NCIT:C20233", "l": "BG01", "d": ["Provider: BresaGen, Inc., Athens, GA. Information from provider and not independently verified by NIH: Cells are positive for cell markers SSEA-3, SSEA-4, TRA 1-60, TRA 1-81, Oct-4, and alkaline phosphatase; Cells are negative for the cell marker SSEA1. This cell line meets the criteria for the use of human embryonic stem cells by federally funded researchers."], "t": []}], "preferred_name": "BG01", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0020018", "l": "proliferative fibrochondrocyte", "d": ["A fibrochondrocyte located in fibrocartilage that exhibits active proliferation capacity and is in S phase of the cell cycle. It functions as a progenitor cell positioned at the root of developmental trajectories alongside fibrochondrocyte progenitors (FCP), with the capacity to diverge toward one of two developmental fates: (1) fibrochondrocytes and prehypertrophic chondrocytes, or (2) regulatory chondrocytes and prehypertrophic chondrocytes. It is characterised by co-expression of COL1A1, the growth factors FGF7 and CTGF, and the cell-cycle genes STMN1, KIAA0101, and MCM3 in humans. During early progenitor differentiation, FGF7 and COL1A1 expression increases and then declines as the cell commits to terminal fates."], "t": []}], "preferred_name": "proliferative fibrochondrocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C3897094", "l": "IL13Ralpha2-specific Hinge-optimized 41BB-co-stimulatory CAR Truncated CD19-expressing Autologous T-Lymphocytes", "d": [], "t": []}, {"i": "NCIT:C117233", "l": "IL13Ralpha2-specific Hinge-optimized 41BB-co-stimulatory CAR Truncated CD19-expressing Autologous T-Lymphocytes", "d": ["A preparation of ex vivo expanded, genetically modified autologous central memory-enriched T-cells (Tcm) transduced with a replication incompetent, self-inactivating (SIN) lentiviral vector expressing a hinge-optimized, chimeric antigen receptor (CAR) specific for interleukin-13 receptor alpha 2 (IL13Ra2), and containing the cluster of differentiation 137 (CD137; 4-1BB) co-stimulatory signaling domain fused to the signaling domain of the T cell antigen receptor complex zeta chain (CD3-zeta), and a truncated form of human cluster of differentiation 19 (CD19t), with potential immunostimulating and antineoplastic activities. Upon intratumoral or intracavitary administration, IL13Ra2-specific, hinge-optimized, 41BB-co-stimulatory CAR/truncated CD19 expressing T-lymphocytes are directed to, and induce selective toxicity and cytolysis in IL13Ra2-expressing tumor cells. IL13Ra2, overexpressed by a variety of tumor cell types, is associated with increased tumor cell proliferation, migration and invasiveness. The costimulatory signaling domain enhances both proliferation of T-cells and antitumor activity. Hinge optimization prevents the recognition and clearance of the CAR by endogenous Fc receptors (FcRs). CD19t is used as a surface marker to both quantify and track the gene modified T-cells in vivo."], "t": []}], "preferred_name": "IL13Ralpha2-specific Hinge-optimized 41BB-co-stimulatory CAR Truncated CD19-expressing Autologous T-Lymphocytes", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C3640216", "l": "TIL 1383I T Cell Receptor-Transduced Autologous T Cells", "d": [], "t": []}, {"i": "NCIT:C101787", "l": "TIL 1383I T Cell Receptor-Transduced Autologous T Cells", "d": ["Autologous peripheral blood lymphocytes-derived T cells transduced with a retroviral encoding TIL 1383I, a T cell receptor (TCR) specific for melanoma antigen tyrosinase, with potential immunostimulating and antineoplastic activity. After transduction, expansion in culture, and reintroduction into the patient, TIL 1383I TCR-transduced autologous T cells bind to tumor cells expressing tyrosinase, which may induce cytokine expression, activation and proliferation of T-cells, and a specific cytotoxic T-lymphocyte (CTL) response against tyrosinase-expressing tumor cells. TIL 1383I TCR originated from a melanoma patient's CD4+ tumor-infiltrating lymphocytes and is reactive against a class I MHC (HLA-A2)-restricted epitope (368-376) of tyrosinase."], "t": []}], "preferred_name": "TIL 1383I T Cell Receptor-Transduced Autologous T Cells", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0229610", "l": "Tissue eosinophil", "d": [], "t": []}, {"i": "SNOMEDCT:55109005", "l": "", "d": [], "t": []}], "preferred_name": "Tissue eosinophil", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "CL:0000032", "l": "neuroplacodal cell", "d": ["A cell of a platelike structure, especially a thickened plate of ectoderm in the early embryo, from which a sense organ develops."], "t": []}], "preferred_name": "neuroplacodal cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1514656", "l": "RL10", "d": [], "t": []}, {"i": "NCIT:C20290", "l": "RL10", "d": ["Provider: Reliance Life Sciences, Mumbai, India. No information from provider. This cell line meets the criteria for the use of human embryonic stem cells by federally funded researchers."], "t": []}], "preferred_name": "RL10", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5154481", "l": "Basophils | Peritoneal fluid | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Basophils | Peritoneal fluid | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0581780", "l": "Stem cell colony-forming unit", "d": [], "t": []}, {"i": "SNOMEDCT:259731003", "l": "", "d": [], "t": []}], "preferred_name": "Stem cell colony-forming unit", "taxa": []}
{"type": "biolink:Cell", "ic": 85.53200374075534, "identifiers": [{"i": "CL:0000690", "l": "R2 photoreceptor cell", "d": [], "t": []}], "preferred_name": "R2 photoreceptor cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1440308", "l": "CD42a+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:1372886000", "l": "", "d": [], "t": []}], "preferred_name": "CD42a+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0333821", "l": "Micromyeloblast", "d": [], "t": []}, {"i": "SNOMEDCT:19651007", "l": "", "d": [], "t": []}], "preferred_name": "Micromyeloblast", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4033180", "l": "dorsal root ganglion peripherin neuron", "d": ["A sensory neuron that has the soma located in the dorsal root ganglion and expresses the intermediate filament protein peripherin (PRPH). Peripherin marks small-diameter unmyelinated C-fiber neurons in the DRG."], "t": []}], "preferred_name": "dorsal root ganglion peripherin neuron", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4033158", "l": "geniculate ganglion SPARCL1 neuron", "d": ["A sensory neuron that has the soma located in the geniculate ganglion and expresses the marker SPARC-like protein 1 (SPARCL1)."], "t": []}], "preferred_name": "geniculate ganglion SPARCL1 neuron", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0009039", "l": "colon goblet cell", "d": ["A goblet cell that is located in the colon."], "t": []}], "preferred_name": "colon goblet cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1507327", "l": "FLAER+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:1381847007", "l": "", "d": [], "t": []}], "preferred_name": "FLAER+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5925681", "l": "Carteyva", "d": [], "t": []}], "preferred_name": "Carteyva", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1524046", "l": "CNS - Brain - Neuron (MMHCC)", "d": [], "t": []}, {"i": "NCIT:C22618", "l": "Mouse Brain Neuron", "d": [], "t": []}], "preferred_name": "CNS - Brain - Neuron (MMHCC)", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C2717771", "l": "Generative Cells, Plant", "d": [], "t": []}], "preferred_name": "Generative Cells, Plant", "taxa": []}
{"type": "biolink:Cell", "ic": 85.53200374075534, "identifiers": [{"i": "CL:0002326", "l": "luminal epithelial cell of mammary gland", "d": ["A mammary epithelial cell that occurs in the lumen of the ductal and alveoli structure in the breast."], "t": []}, {"i": "UMLS:C1183712", "l": "Luminal cell of lactiferous gland", "d": [], "t": []}], "preferred_name": "luminal epithelial cell of mammary gland", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "UMLS:C2350466", "l": "Natural Killer T-Cells", "d": [], "t": []}, {"i": "NCIT:C129906", "l": "Natural Killer T-Cell", "d": ["A subset of T-lymphocytes that coexpress an alpha/beta T-cell receptor, and variety of molecular markers that are typically associated with natural killer (NK) cells, which may include CD161, CD16, CD68, and granzyme. NK T-cells recognize glycolipids presented by antigen-presenting glycoprotein CD1d on antigen presenting cells; antigen recognition stimulates a rapid release of various cytokines from the NK T-cells."], "t": []}, {"i": "MESH:D055611", "l": "Natural Killer T-Cells", "d": [], "t": []}], "preferred_name": "Natural Killer T-Cells", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4072007", "l": "A10 dopaminergic neuron", "d": ["A type of dopaminergic neuron found in the ventral tegmental area that is involved in reward processes, motivation and addiction."], "t": []}], "preferred_name": "A10 dopaminergic neuron", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5572422", "l": "Superficial transitional cells | Urine sediment | Urinalysis", "d": [], "t": []}], "preferred_name": "Superficial transitional cells | Urine sediment | Urinalysis", "taxa": []}
{"type": "biolink:Cell", "ic": 79.35380886648232, "identifiers": [{"i": "UMLS:C1883265", "l": "Tall Columnar Adenocarcinoma Cell", "d": [], "t": []}, {"i": "NCIT:C60531", "l": "Tall Columnar Adenocarcinoma Cell", "d": [], "t": []}], "preferred_name": "Tall Columnar Adenocarcinoma Cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1267843", "l": "Lymphocyte positive for both CD4 antigen and CD8 antigen", "d": [], "t": []}, {"i": "SNOMEDCT:117530008", "l": "", "d": [], "t": []}], "preferred_name": "Lymphocyte positive for both CD4 antigen and CD8 antigen", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5966019", "l": "Deltacel (TM)", "d": [], "t": []}], "preferred_name": "Deltacel (TM)", "taxa": []}
{"type": "biolink:Cell", "ic": 87.18682603146104, "identifiers": [{"i": "UMLS:C3273605", "l": "Disseminated Tumor Cell", "d": [], "t": []}, {"i": "NCIT:C97750", "l": "Disseminated Tumor Cell", "d": ["Metastatic tumor cells found singly or in small clusters in the tissues."], "t": []}], "preferred_name": "Disseminated Tumor Cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1955926", "l": "Pro-B Lymphocytes", "d": [], "t": []}], "preferred_name": "Pro-B Lymphocytes", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0086031", "l": "Colony-Forming Units, Hematopoietic", "d": [], "t": []}], "preferred_name": "Colony-Forming Units, Hematopoietic", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "UMLS:C1881550", "l": "Malignant Epithelial Medium-Sized Polygonal Cell", "d": [], "t": []}, {"i": "NCIT:C61002", "l": "Malignant Epithelial Medium-Sized Polygonal Cell", "d": [], "t": []}], "preferred_name": "Malignant Epithelial Medium-Sized Polygonal Cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1267978", "l": "Lymphocyte positive for CD88 antigen", "d": [], "t": []}, {"i": "SNOMEDCT:117418000", "l": "", "d": [], "t": []}], "preferred_name": "Lymphocyte positive for CD88 antigen", "taxa": []}
{"type": "biolink:Cell", "ic": 66.22131566187467, "identifiers": [{"i": "UMLS:C1518981", "l": "Perineural Cell", "d": [], "t": []}, {"i": "NCIT:C41416", "l": "Perineural Cell", "d": ["A cell surrounding a neuron."], "t": []}], "preferred_name": "Perineural Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4023001", "l": "static beta motor neuron", "d": ["A beta motor neuron that innervates nuclear chain fibers."], "t": []}], "preferred_name": "static beta motor neuron", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1267962", "l": "Lymphocyte positive for CD66E antigen", "d": [], "t": []}, {"i": "SNOMEDCT:117403001", "l": "", "d": [], "t": []}], "preferred_name": "Lymphocyte positive for CD66E antigen", "taxa": []}
{"type": "biolink:Cell", "ic": 92.76600187037766, "identifiers": [{"i": "CL:4033097", "l": "Schlemm's canal endothelial cell", "d": ["A specialised endothelial cell that is part of the canal of Schlemm. This cell type shares characteristics and expresses markers of both blood and lymphatic endothelial cells (Kizhatil et al., 2014) and regulates aqueous humor outflow resistance by modulating pore formation and responding to mechanical strain (Stamer et al., 2015)."], "t": []}], "preferred_name": "Schlemm's canal endothelial cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1268000", "l": "Lymphocyte positive for CD122 antigen", "d": [], "t": []}, {"i": "SNOMEDCT:117440009", "l": "", "d": [], "t": []}], "preferred_name": "Lymphocyte positive for CD122 antigen", "taxa": []}
{"type": "biolink:Cell", "ic": 92.76600187037766, "identifiers": [{"i": "CL:0008049", "l": "Betz cell", "d": ["A giant pyramidal neuron with a soma in layer Vb of the primary motor cortex that sends its axons down the spinal cord via the corticospinal tract, either synapsing directly with alpha motor neurons, or targeting interneurons in the spinal cord. In humans, Betz cells are the largest known in the central nervous system."], "t": []}], "preferred_name": "Betz cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1257774", "l": "Granulocyte Precursor Cells", "d": [], "t": []}, {"i": "MESH:D042381", "l": "Granulocyte Precursor Cells", "d": [], "t": []}], "preferred_name": "Granulocyte Precursor Cells", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4510903", "l": "Blast cell positive for CD11b antigen", "d": [], "t": []}, {"i": "SNOMEDCT:724243007", "l": "", "d": [], "t": []}], "preferred_name": "Blast cell positive for CD11b antigen", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4307052", "l": "Astro-OLF NN_1 Stk32a astrocyte (Mmus)", "d": ["A astrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Aqp4 (Mmus), Prss23 (Mmus), Stk32a (Mmus). It is distinguished from other Astro-OLF NN_1 cells by expression of Stk32a. These cells are located in the Olfactory areas, brain , in or close to the regions: olfactory nerve layer of main olfactory bulb, Main olfactory bulb . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5232 Astro-OLF NN_1."], "t": []}], "preferred_name": "Astro-OLF NN_1 Stk32a astrocyte (Mmus)", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5161797", "l": "Cytoplasmic CD179a blasts | XXX | Cell markers", "d": [], "t": []}], "preferred_name": "Cytoplasmic CD179a blasts | XXX | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1267917", "l": "Lymphocyte positive for CD40 antigen", "d": [], "t": []}, {"i": "SNOMEDCT:117585007", "l": "", "d": [], "t": []}], "preferred_name": "Lymphocyte positive for CD40 antigen", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4551909", "l": "Bone Marrow Stromal Stem Cells", "d": [], "t": []}, {"i": "SNOMEDCT:418460001", "l": "", "d": [], "t": []}], "preferred_name": "Bone Marrow Stromal Stem Cells", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5446902", "l": "Allogeneic Anti-CD30 CAR-Epstein-Barr Virus-specific T-lymphocytes", "d": [], "t": []}, {"i": "NCIT:C175980", "l": "Allogeneic Anti-CD30 CAR-Epstein-Barr Virus-specific T-lymphocytes", "d": ["A preparation of allogeneic human Epstein-Barr virus (EBV)-specific T-lymphocytes (EBVSTs) that have been genetically modified to express a chimeric antigen receptor (CAR) recognizing the tumor-associated antigen (TAA) cluster of differentiation 30 (CD30), with potential immunostimulating and antineoplastic activities. Upon administration, allogeneic anti-CD30 CAR-EBVSTs specifically recognize and bind to CD30-expressing EBV-infected tumor cells, resulting in tumor cell lysis. CD30, a cell surface receptor and a member of the tumor necrosis factor (TNF) receptor superfamily, is transiently expressed on activated lymphocytes and is constitutively expressed in hematologic malignancies. EBV, a ubiquitous human herpes virus, is associated with various malignancies, including nasopharyngeal carcinoma, Hodgkin disease, non-Hodgkin lymphoma, and other lymphomas."], "t": []}], "preferred_name": "Allogeneic Anti-CD30 CAR-Epstein-Barr Virus-specific T-lymphocytes", "taxa": []}
{"type": "biolink:Cell", "ic": 89.40238429118027, "identifiers": [{"i": "CL:0003020", "l": "retinal ganglion cell C outer", "d": ["A retinal ganglion cell C that has post-synaptic terminals in S2."], "t": []}], "preferred_name": "retinal ganglion cell C outer", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1441341", "l": "100 erythrocytes", "d": [], "t": []}], "preferred_name": "100 erythrocytes", "taxa": []}
{"type": "biolink:Cell", "ic": 87.18682603146104, "identifiers": [{"i": "CL:0002400", "l": "fraction B/C precursor B cell", "d": ["A precursor B cell that is AA4-positive, IgM-negative, CD19-positive, CD43-positive and HSA-positive."], "t": []}], "preferred_name": "fraction B/C precursor B cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4033119", "l": "thoracic ganglion TH neuron", "d": ["A sympathetic neuron that has the soma located in the thoracic ganglion and expresses the marker tyrosine hydroxylase (TH)."], "t": []}], "preferred_name": "thoracic ganglion TH neuron", "taxa": []}
{"type": "biolink:Cell", "ic": 67.8984399852903, "identifiers": [{"i": "CL:0000083", "l": "epithelial cell of pancreas", "d": ["An epithelial cell of the pancreas."], "t": []}], "preferred_name": "epithelial cell of pancreas", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0282479", "l": "Muscle Fibers, Red", "d": [], "t": []}], "preferred_name": "Muscle Fibers, Red", "taxa": []}
{"type": "biolink:Cell", "ic": 84.83823963392128, "identifiers": [{"i": "CL:0000644", "l": "Bergmann glial cell", "d": ["Type of radial astrocyte in the cerebellar cortex that have their cell bodies in the Purkinje cell layer and processes that extend into the molecular layer, terminating with bulbous endfeet at the pial surface. Bergmann glia express high densities of glutamate transporters that limit diffusion of the neurotransmitter glutamate during its release from synaptic terminals. Besides their role in early development of the cerebellum, Bergmann glia are also required for the pruning or addition of synapses."], "t": []}], "preferred_name": "Bergmann glial cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0002562", "l": "hair germinal matrix cell", "d": ["An epidermal cell that is part of the germinal matrix."], "t": []}], "preferred_name": "hair germinal matrix cell", "taxa": []}
{"type": "biolink:Cell", "ic": 76.04769967783396, "identifiers": [{"i": "UMLS:C1881561", "l": "Malignant Intermediate Type Trophoblastic Cell", "d": [], "t": []}, {"i": "NCIT:C61405", "l": "Malignant Intermediate Type Trophoblastic Cell", "d": [], "t": []}], "preferred_name": "Malignant Intermediate Type Trophoblastic Cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0546500", "l": "P.B. megakaryoblast", "d": [], "t": []}], "preferred_name": "P.B. megakaryoblast", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5554913", "l": "Autologous BAFFR-targeting CAR T Cells", "d": [], "t": []}, {"i": "NCIT:C178272", "l": "Autologous BAFFR-targeting CAR T Cells", "d": ["A preparation of autologous T-lymphocytes that are genetically engineered to express a chimeric antigen receptor (CAR) specific for the tumor-associated antigen (TAA) B-cell activating factor receptor (BAFFR; tumor necrosis factor receptor superfamily member 13C; TNFRSF13C; BLyS receptor 3; BR3), with potential immunostimulating and antineoplastic activities. Upon administration, the autologous BAFFR-targeting CAR T cells are directed to and induce selective toxicity in BAFFR-expressing tumor cells. BAFFR, a protein belonging to the TNF receptor superfamily, is expressed on the surface of certain types of cancer cells, including B-cell acute lymphoblastic leukemia. It plays a key role in the regulation of peripheral B-cell survival."], "t": []}], "preferred_name": "Autologous BAFFR-targeting CAR T Cells", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4307039", "l": "Astro-TE NN_1 Rasl10b astrocyte (Mmus)", "d": ["A astrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Gfap (Mmus), Ddn (Mmus), Myoc (Mmus), Rasl10b (Mmus). It is distinguished from other Astro-TE NN_1 cells by expression of Rasl10b, Igfbp5. These cells are located in the Hippocampal region, Isocortex, brain . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5219 Astro-TE NN_1."], "t": []}], "preferred_name": "Astro-TE NN_1 Rasl10b astrocyte (Mmus)", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1979664", "l": "CD13+CD33+HLA-DR+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:1373153007", "l": "", "d": [], "t": []}], "preferred_name": "CD13+CD33+HLA-DR+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4687632", "l": "Dilanubicel", "d": [], "t": []}], "preferred_name": "Dilanubicel", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5206754", "l": "Anti-CD70 CAR-expressing T Lymphocytes", "d": [], "t": []}, {"i": "NCIT:C162699", "l": "Anti-CD70 CAR-expressing T Lymphocytes", "d": ["A preparation of human T-lymphocytes transduced with a recombinant viral vector encoding a chimeric T-cell receptor (chimeric antigen receptor or CAR) consisting of one or more binding domains that target the tumor-associated antigen (TAA) CD70 (CD27 ligand; tumor necrosis factor superfamily member 7; TNFSF7) fused to one or more co-stimulatory TCR-signaling domains, with potential immunostimulating and antineoplastic activities. Upon administration, the anti-CD70 CAR-expressing T-lymphocytes, express anti-CD70-CAR on their cell surfaces and bind to the CD70 antigen on tumor cell surfaces thereby neutralizing the activity of CD70. This may induce antibody-dependent cellular cytotoxicity (ADCC) against CD70-expressing tumor cells. CD70, a cytokine belonging to the tumor necrosis superfamily (TNFSF) and the ligand for the costimulatory receptor CD27, is expressed on the surfaces of various types of cancer cells; its overexpression may play an important role in the evasion of immune surveillance."], "t": []}], "preferred_name": "Anti-CD70 CAR-expressing T Lymphocytes", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "CL:0000936", "l": "early lymphoid progenitor", "d": ["A lymphoid progenitor cell that is found in bone marrow, gives rise to B cells, T cells, natural killer cells and dendritic cells, and has the phenotype Lin-negative, Kit-positive, Sca-1-positive, FLT3-positive, CD34-positive, CD150 negative, and GlyA-negative."], "t": []}], "preferred_name": "early lymphoid progenitor", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "UMLS:C1879716", "l": "Apocrine Carcinoma Cell with Eosinophilic Granular Cytoplasm", "d": [], "t": []}, {"i": "NCIT:C62206", "l": "Apocrine Carcinoma Cell with Eosinophilic Granular Cytoplasm", "d": [], "t": []}], "preferred_name": "Apocrine Carcinoma Cell with Eosinophilic Granular Cytoplasm", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C6063237", "l": "Cell positive for CD5 antigen and CD19 antigen", "d": [], "t": []}, {"i": "SNOMEDCT:1373037006", "l": "", "d": [], "t": []}], "preferred_name": "Cell positive for CD5 antigen and CD19 antigen", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "UMLS:C1519318", "l": "Signet Ring-Like Neoplastic T-Lymphocyte", "d": [], "t": []}, {"i": "NCIT:C39683", "l": "Signet Ring-Like Neoplastic T-Lymphocyte", "d": [], "t": []}], "preferred_name": "Signet Ring-Like Neoplastic T-Lymphocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:2000027", "l": "cerebellar basket cell", "d": ["A GABAergic inhibitory interneuron located in the molecular layer of the cerebellar cortex. It projects axons that form specialized synaptic structures around Purkinje cells, including pericellular baskets, which wrap around the Purkinje cell soma, and the pinceau: a brush-like terminal that contacts the initial segment of the Purkinje cell axon. The basket cell modulates Purkinje cell activity through both chemical (GABAergic) and non-synaptic (ephaptic) mechanisms. It is arranged in sagittal rows that align with Purkinje cell zones, contributing to the cerebellum's modular and topographically organized architecture. It plays an essential role in regulating motor coordination and potentially cognitive functions."], "t": []}], "preferred_name": "cerebellar basket cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5157395", "l": "CD22 blasts | XXX | Cell markers", "d": [], "t": []}], "preferred_name": "CD22 blasts | XXX | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1440410", "l": "Cells.t(21;22)(q22.3;q12.2)(ERG,EWSR1)", "d": [], "t": []}], "preferred_name": "Cells.t(21;22)(q22.3;q12.2)(ERG,EWSR1)", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5238225", "l": "Chlorotoxin (EQ)-CD28-CD3zeta-CD19t-expressing CAR T-lymphocytes", "d": [], "t": []}, {"i": "NCIT:C167056", "l": "Chlorotoxin (EQ)-CD28-CD3zeta-CD19t-expressing CAR T-lymphocytes", "d": ["A preparation of genetically modified T-lymphocytes transduced with a lentiviral vector expressing a chimeric antigen receptor (CAR) comprised of a CD28 co-stimulatory signaling domain fused to the zeta chain of the TCR/CD3 complex (CD3zeta), a truncated form of CD19 (CD19t), an immunoglobulin (Ig) G4-Fc (EQ) spacer, and a peptide derived from chlorotoxin (CLTX), with potential imaging and antineoplastic activities. Upon administration, chlorotoxin (EQ)-CD28-CD3zeta-CD19t-expressing CAR T-lymphocytes are re-directed to specific tumor cells in the brain inducing selective toxicity in these tumor cells. CLTX, a 36-amino acid peptide found in the venom of the deathstalker scorpion (Leiurus quinquestriatus) and a chloride channel blocker, preferentially binds to glioma (and other neuroectodermal origin) cells via membrane bound forms of the endopeptidase matrix metalloproteinase-2 (MMP-2). This may direct the T-lymphocytes to and induce selective toxicity in MMP-2-expressing tumor cells. Additionally, binding to MMP-2 on glioma cells may both interfere with transmembrane chloride exchange and inhibit proteolytic extracellular matrix remodeling by MMP-2, which may further limit the spread of these tumor cells. MMP-2 is specifically upregulated in gliomas and related cancers, but is not normally expressed in brain. The CD28 co-stimulatory molecule signaling domain enhances activation and signaling; its inclusion may increase proliferation of T-cells and antitumor activity compared to the inclusion of the CD3 zeta chain alone. IgG4-Fc (EQ) contains two point mutations in its spacer region which prevents recognition of the CAR by Fc receptors (FcRs) without altering the ability of the CAR to mediate antigen-specific lysis. CD19t, which lacks the cytoplasmic signaling tail, provides a non-immunogenic surface marker that allows for accurate measurement, efficient cell tracking and/or imaging of the therapeutic T-cells in vivo following adoptive transfer. Additionally, co-expression of CD19t functions as a \"suicide\" switch via clinically available antibodies or immunotoxins which can be used to selectively eliminate the genetically modified cells."], "t": []}], "preferred_name": "Chlorotoxin (EQ)-CD28-CD3zeta-CD19t-expressing CAR T-lymphocytes", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4322818", "l": "CD99+ T lymphocyte", "d": [], "t": []}], "preferred_name": "CD99+ T lymphocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4033164", "l": "myenteric ganglion of small intestine nNOS/ChAT neuron", "d": ["An enteric neuron that has the soma located in the myenteric ganglion of the small intestine and expresses the marker neuronal nitric oxide synthase 1 (nNOS) and choline O-acetyltransferase (ChAT)."], "t": []}], "preferred_name": "myenteric ganglion of small intestine nNOS/ChAT neuron", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C2924227", "l": "CD7+CD34+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:1373046000", "l": "", "d": [], "t": []}], "preferred_name": "CD7+CD34+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0376351", "l": "Photoreceptor Cells, Vertebrate", "d": [], "t": []}, {"i": "MESH:D020419", "l": "Photoreceptor Cells, Vertebrate", "d": [], "t": []}], "preferred_name": "Photoreceptor Cells, Vertebrate", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C4725796", "l": "Autologous Anti-EGFRvIII 4SCAR-IgT Cells", "d": [], "t": []}, {"i": "NCIT:C150518", "l": "Autologous Anti-EGFRvIII 4SCAR-IgT Cells", "d": ["A preparation of autologous T-cells that are genetically modified to express immunoglobulins (Igs) that target the negative immunoregulatory human cell surface receptor programmed cell death protein 1 (PD-1; PDCD1; CD279) and programmed death-ligand 1 (PD-L1; CD274) and are transduced with a replication incompetent, self-inactivating lentiviral vector expressing a fourth generation chimeric antigen receptor (4SCAR) consisting of a single chain variable fragment (scFv) targeting anti-epidermal growth factor receptor variant III (EGFRvIII) that is coupled to the costimulatory signaling domains CD28, CD137, CD27 and the zeta chain of the T-cell receptor (TCR), and is fused with the suicide gene inducible caspase 9 (iCasp9), with potential immunostimulating and antineoplastic activities. Upon administration, autologous anti-EGFRvIII 4SCAR-IgT cells are directed to and induce selective toxicity in EGFRvIII-expressing tumor cells. iCasp9 consists of a human FK506 drug-binding domain with an F36V mutation (FKBP12-F36V) linked to human caspase 9. If the administered T-cells lead to unacceptable side effects, the chemical homodimerizer AP1903 can be administered. AP1903 binds to the drug binding FKBP12-F36V domain and induces activation of caspase 9, which results in the apoptosis of the administered T-cells and enhances safety of this agent. EGFRvIII, a tumor-associated antigen (TAA) encoded by an in-frame deletion of exons 2-7 in the EGFR gene, is overexpressed by a variety of cancer cell types and is not expressed by normal, healthy cells. It plays a key role in tumor cell proliferation, tumor angiogenesis and resistance to both radio- and chemotherapy. CD28, CD137 and CD27, T-cell surface-associated co-stimulatory molecules, are required for full T-cell activation and enhance both proliferation of T-cells and antitumor activity. The anti-PD-1 and anti-PD-L1 antibodies produced by the T-cells (IgT) bind to PD-1, expressed on T-cells, and its ligand PD-L1 expressed on cancer cells, respectively. This inhibits PD-1/PD-L1-mediated signaling, prevents T-cell inhibition and exhaustion, enhances T-cell activation within the tumor microenvironment (TME) and results in an enhanced T-cell-mediated immune response against and toxicity in the EGFRvIII-expressing tumor cells."], "t": []}], "preferred_name": "Autologous Anti-EGFRvIII 4SCAR-IgT Cells", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5556476", "l": "Autologous Anti-CD19 CAR T Cells CRC01", "d": [], "t": []}], "preferred_name": "Autologous Anti-CD19 CAR T Cells CRC01", "taxa": []}
{"type": "biolink:Cell", "ic": 86.30756602822301, "identifiers": [{"i": "CL:0000905", "l": "effector memory CD4-positive, alpha-beta T cell", "d": ["CD4-positive, alpha-beta memory T cell with the phenotype CCR7-negative, CD127-positive, CD45RA-negative, CD45RO-positive, and CD25-negative."], "t": []}], "preferred_name": "effector memory CD4-positive, alpha-beta T cell", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "CL:0002294", "l": "type-1 epithelial cell of thymus", "d": ["An epithelial cell with a well defined Golgi apparatus that makes up the continuous layer of cells bordering the thymic tissue beneath the capsule."], "t": []}, {"i": "UMLS:C1183357", "l": "Type-1 epithelial cell of thymus", "d": [], "t": []}], "preferred_name": "type-1 epithelial cell of thymus", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5856947", "l": "Autologous B7-H3/EGFR806/HER2/IL13-zetakine CAR-expressing CD4+/CD8+ T-cells SC-CAR4BRAIN", "d": [], "t": []}, {"i": "NCIT:C200272", "l": "Autologous B7-H3/EGFR806/HER2/IL13-zetakine CAR-expressing CD4+/CD8+ T-cells SC-CAR4BRAIN", "d": ["A preparation of autologous CD4+ and CD8+ T-lymphocytes transduced with a lentiviral vector to express four chimeric antigen receptors (CARs) targeting the immunoregulatory protein B7-homologue 3 (B7-H3, CD276), epidermal growth factor receptor (EGFR) mAb806 epitope, human epidermal growth factor 2 (HER2; ErbB2; HER-2), and interleukin-13 receptor alpha 2 (IL13Ra2), with potential immunostimulating and antineoplastic activities. Upon administration, autologous B7-H3/EGFR806/HER2/IL13-zetakine CAR-expressing CD4+/CD8+ T-cells SC-CAR4BRAIN target and bind to tumor cells that express B7-H3, EGFR mAb806 epitope, HER2 and IL13Ra2, thereby inducing selective toxicity in these cells. B7-H3, a type I transmembrane protein and a member of the B7 co-stimulatory protein superfamily, is overexpressed on certain tumor cell types and on various immune cells. It is a negative regulator of T-cell activation and its overexpression plays a key role in tumor cell invasion and metastasis. EGFR, overexpressed by a variety of cancer cell types, plays a key role in tumor cell proliferation, tumor angiogenesis and radio- and chemoresistance. EGFR806 CAR specifically targets abnormal conformational states of EGFR, including EGFR deletion mutation variant III (EGFRvIII), and activating mutations, with lower affinity for wild-type EGFR. HER2 is overexpressed in a variety of cancer cell types and is associated with increased tumor cell proliferation. IL13Ra2, a cancer-associated receptor, is overexpressed by a variety of tumor cell types including glioblastoma multiforme (GBM); it is associated with increased invasiveness of tumor cells."], "t": []}], "preferred_name": "Autologous B7-H3/EGFR806/HER2/IL13-zetakine CAR-expressing CD4+/CD8+ T-cells SC-CAR4BRAIN", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5216250", "l": "Lymphocytes|NCnc|Pt|Body fld", "d": [], "t": []}], "preferred_name": "Lymphocytes|NCnc|Pt|Body fld", "taxa": []}
{"type": "biolink:Cell", "ic": 73.15076615569336, "identifiers": [{"i": "CL:0000646", "l": "basal cell", "d": ["Undifferentiated; mitotic stem cell for other epithelial cell types; rounded or elliptical with little cytoplasm and few organelles; contain cytokeratin intermediate filament."], "t": []}, {"i": "UMLS:C0596155", "l": "Basal Cell", "d": [], "t": []}, {"i": "NCIT:C12475", "l": "Skin Basal Cell", "d": ["A cuboidal or low columnar cell in the deepest epidermal layer, stratum basale (stratum germinativum), adjacent to the basal lamina."], "t": []}], "preferred_name": "basal cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5854632", "l": "Autologous Anti-MAGE-A1 TCR-engineered T-cells TSC-204-C0702", "d": [], "t": []}, {"i": "NCIT:C201132", "l": "Autologous Anti-MAGE-A1 TCR-engineered T-cells TSC-204-C0702", "d": ["A preparation of autologous T-lymphocytes that are engineered to express a T-cell receptor (TCR) specific for melanoma-associated antigen A1 (MAGE-A1) presented on human leukocyte antigen (HLA)-C*07:02, with potential immunomodulating and antineoplastic activities. Upon administration, the autologous anti-MAGE-A1 TCR-engineered T-cells TSC-204-C0702 specifically recognize and bind to MAGE-A1 expressed on tumor cells. This may lead to cytotoxic T-lymphocyte (CTL)-mediated elimination of tumor cells expressing MAGE-A1. MAGE-A1 is a tumor-associated antigen (TAA) overexpressed by a variety of cancer cell types."], "t": []}], "preferred_name": "Autologous Anti-MAGE-A1 TCR-engineered T-cells TSC-204-C0702", "taxa": []}
{"type": "biolink:Cell", "ic": 50.575197783291856, "identifiers": [{"i": "CL:0012001", "l": "neuron of the forebrain", "d": ["A CNS neuron of the forebrain."], "t": []}], "preferred_name": "neuron of the forebrain", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4033179", "l": "dorsal root ganglion Nav1.9 neuron", "d": ["A sensory neuron that has the soma located in the dorsal root ganglion and expresses the marker sodium channel protein type 11 subunit alpha (Nav1.9/SCN11A). Nav1.9 is present in approximately 26% of TrkA-positive human DRG neurons and defines a nociceptor subpopulation."], "t": []}], "preferred_name": "dorsal root ganglion Nav1.9 neuron", "taxa": []}
{"type": "biolink:Cell", "ic": 81.34422831136257, "identifiers": [{"i": "CL:0002255", "l": "stromal cell of endometrium", "d": ["A stromal cell of the endometrium, characterized by its fibroblast-like morphology, regenerative capacity, and ability to undergo decidualization. It differentiates into a decidual stromal cell during pregnancy, essential for embryo implantation and maintenance. This cell is involved in tissue proliferation, remodeling, and breakdown, responding to hormonal changes, particularly estrogen and progesterone."], "t": []}, {"i": "UMLS:C1516859", "l": "Stromal cell of endometrium", "d": [], "t": []}, {"i": "NCIT:C33921", "l": "Endometrial Stromal Cell", "d": ["A cell of the uterine wall immediately underling the endometrial epithelium. Endometrial stromal cells proliferate and respond to the cyclic variations of estrogen and progesterone. These cells produce growth factors and hormones that mediate the proliferative response of epithelial cells to the steroid hormones estrogen and progesterone. In response to embryo implantation, endometrial stromal cells accumulate lipid and glycogen."], "t": []}], "preferred_name": "stromal cell of endometrium", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5216276", "l": "Monocytes|NCnc|Pt|Plr fld", "d": [], "t": []}], "preferred_name": "Monocytes|NCnc|Pt|Plr fld", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C4764271", "l": "Autologous Anti-MUC16 CAR-mbIL15-Safety Switch T-cells PRGN-3005", "d": [], "t": []}, {"i": "NCIT:C158533", "l": "Autologous Anti-MUC16 CAR-mbIL15-Safety Switch T-cells PRGN-3005", "d": ["A preparation of autologous T-lymphocytes that have been genetically modified to co-express three transgenes using the Sleeping Beauty (SB) transposon system and include a chimeric antigen receptor (CAR) targeting the unshed portion of the tumor-associated antigen (TAA) human mucin 16 (MUC16, cancer antigen 125; CA125; FLJ14303), a membrane-bound IL-15 (mbIL15) and a safety/kill switch, with potential immunostimulating and antineoplastic activities. Upon introduction of the autologous anti-MUC16 CAR-mbIL15-safety switch T-cells PRGN-3005 into the patient, the T-cells target and bind to MUC16-expressing tumor cells, thereby inducing selective toxicity in MUC16-expressing tumor cells. MUC16, a member of the mucin family of glycoproteins, is overexpressed on a variety of cancer cell types. IL-15 is a pro-survival cytokine that is required for the maintenance of long-lived CD8+ memory T-cells and use of mbIL15 preserves T stem-cell memory (TSCM) through sustained IL-15 signaling, improves T-cell persistence and potentiates the immune response against tumor cells. The safety switch can promote selective elimination of the CAR-T cells. The SB system permits integration of the CAR, the IL-15 fusion variant and safety switch transgenes into T-cells without the need for viral vectors and accelerates the manufacturing process."], "t": []}], "preferred_name": "Autologous Anti-MUC16 CAR-mbIL15-Safety Switch T-cells PRGN-3005", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "CL:0020059", "l": "serous demilune cell of salivary gland", "d": ["A serous secreting cell that is part of a salivary gland, forming crescent-shaped (demilune) caps at the distal ends of mucous acini in mixed glands. Prominent in human submandibular and sublingual glands, this cell delivers its watery, enzyme-rich secretions including alpha-amylase through intercellular canaliculi that run between adjacent mucous cells to reach the acinar lumen (Amano et al., 2012). In rodents, these cells also express neuronal nitric oxide synthase (nNOS)."], "t": []}], "preferred_name": "serous demilune cell of salivary gland", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4310117", "l": "SN-VTR-HTH GATA3-TCF7L2 GABA GABAergic interneuron (Primate)", "d": ["A GABAergic interneuron of the Primates brain. These cells are located in the substantia nigra . Reference transcriptomic data for this type can be found in the dataset/taxonomy - HMBA Basal Ganglia Consensus Taxonomy in cell set Group:SN-VTR-HTH GATA3-TCF7L2 GABA."], "t": []}], "preferred_name": "SN-VTR-HTH GATA3-TCF7L2 GABA GABAergic interneuron (Primate)", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5216291", "l": "Neutrophils|NCnc|Pt|Body fld", "d": [], "t": []}], "preferred_name": "Neutrophils|NCnc|Pt|Body fld", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5959727", "l": "Irregularly Contracted Erythrocyte", "d": [], "t": []}, {"i": "NCIT:C206312", "l": "Irregularly Contracted Erythrocyte", "d": ["A red blood cell that lacks central pallor, with hemoglobin that appears condensed and irregularly distributed in the cell."], "t": []}], "preferred_name": "Irregularly Contracted Erythrocyte", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1441017", "l": "Neutrophil cytoplasmic", "d": [], "t": []}], "preferred_name": "Neutrophil cytoplasmic", "taxa": []}
{"type": "biolink:Cell", "ic": 92.76600187037766, "identifiers": [{"i": "CL:0001044", "l": "effector CD4-positive, alpha-beta T cell", "d": ["A CD4-positive, alpha-beta T cell with the phenotype CCR7-negative, CD45RA-positive."], "t": []}], "preferred_name": "effector CD4-positive, alpha-beta T cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0333839", "l": "Lipid histiocyte", "d": [], "t": []}, {"i": "SNOMEDCT:76237002", "l": "", "d": [], "t": []}], "preferred_name": "Lipid histiocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 65.69725873753356, "identifiers": [{"i": "UMLS:C1517811", "l": "Leukemic Plasma Cell", "d": [], "t": []}, {"i": "NCIT:C41071", "l": "Leukemic Plasma Cell", "d": [], "t": []}], "preferred_name": "Leukemic Plasma Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 87.18682603146104, "identifiers": [{"i": "CL:0002071", "l": "enterocyte of epithelium of large intestine", "d": ["A columnar absorptive epithelial cell found in the epithelium of large intestine, specialized for water and electrolyte absorption. Unlike small intestinal enterocytes, those in the large intestine have fewer apical microvilli."], "t": []}, {"i": "UMLS:C2324975", "l": "Enterocyte of epithelium proper of large intestine", "d": [], "t": []}], "preferred_name": "enterocyte of epithelium of large intestine", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0000629", "l": "storage cell", "d": ["A cell that is specialized to store a particular substance(s), which is(are) later released from the store for a particular purpose."], "t": []}], "preferred_name": "storage cell", "taxa": []}
{"type": "biolink:Cell", "ic": 87.18682603146104, "identifiers": [{"i": "CL:0000155", "l": "peptic cell", "d": ["An epithelial cell of the stomach that is part of the fundic gastric gland. This cell is characterized by a basally located nucleus, abundant rough endoplasmic reticulum, and large apical secretory granules. It produces and secretes pepsinogen, the inactive precursor of the digestive enzyme pepsin."], "t": []}, {"i": "UMLS:C0524987", "l": "Chief Cells, Gastric", "d": [], "t": []}, {"i": "NCIT:C32305", "l": "Chief Cell of the Stomach", "d": ["An epithelial cell of the stomach that secretes digestive enzymes. Chief cells may be found at any level in the fundic glands, but are most common in the deeper region, toward the muscularis mucosae. They are basophilic."], "t": []}, {"i": "MESH:D019872", "l": "Chief Cells, Gastric", "d": [], "t": []}, {"i": "SNOMEDCT:70935009", "l": "", "d": [], "t": []}], "preferred_name": "peptic cell", "taxa": []}
{"type": "biolink:Cell", "ic": 84.83823963392128, "identifiers": [{"i": "CL:0009116", "l": "progenitor cell of mammary luminal epithelium", "d": ["A progenitor cell with the potential to differentiate into luminal epithelial cells of mammary glands. In mouse, CD61 and c-kit were found to be coexpressed by the majority of, but not all, committed luminal progenitor cells."], "t": []}], "preferred_name": "progenitor cell of mammary luminal epithelium", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0314587", "l": "Colony-forming unit of granulocytic lineage (cell)", "d": [], "t": []}, {"i": "SNOMEDCT:445400007", "l": "", "d": [], "t": []}], "preferred_name": "Colony-forming unit of granulocytic lineage (cell)", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:1000372", "l": "transitional myocyte of atrial part of atrioventricular bundle", "d": ["A transitional myocyte that is part of the atrial part of atrioventricular bundle."], "t": []}, {"i": "UMLS:C2330614", "l": "Transitional myocyte of atrial part of atrioventricular bundle", "d": [], "t": []}], "preferred_name": "transitional myocyte of atrial part of atrioventricular bundle", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5216299", "l": "Nucleated cells|NCnc|Pt|CSF", "d": [], "t": []}], "preferred_name": "Nucleated cells|NCnc|Pt|CSF", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C4763556", "l": "Autologous CT-RCC-1 HERV-E-TCR-transduced-HLA-A11-restricted CD8+/CD34t+ T-cells", "d": [], "t": []}, {"i": "NCIT:C157344", "l": "Autologous CT-RCC-1 HERV-E-TCR-transduced-HLA-A11-restricted CD8+/CD34t+ T-cells", "d": ["A preparation of autologous T-lymphocytes transduced with a retroviral vector encoding a T-cell receptor (TCR) sequence specific for CT-RCC-1, a tumor-associated antigen (TAA) and HLA-A11-restricted peptide encoded by human endogenous retrovirus (HERV) type E as well as a truncated CD34 chain (CD34t), with potential antineoplastic activity. Upon isolation, transduction, expansion ex vivo and re-introduction into the patient, the autologous CT-RCC-1 HERV-E-TCR-transduced-HLA-A11-restricted CD8+/CD34t+ T-cells bind to and induce selective toxicity in tumor cells expressing both the HLA-A11 allele and the CT-RCC-1 HERV-E antigen. The CD34t protein allows the transduced cells to be identified with an anti-CD34 antibody, and facilitates monitoring of the genetically modified T-cells following adoptive transfer. CT-RCC-1 HERV-E is a TAA found in a high percentage of clear cell renal cell carcinoma (ccRCC) cells."], "t": []}], "preferred_name": "Autologous CT-RCC-1 HERV-E-TCR-transduced-HLA-A11-restricted CD8+/CD34t+ T-cells", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1292101", "l": "IgM B lymphocyte", "d": [], "t": []}, {"i": "SNOMEDCT:115607006", "l": "", "d": [], "t": []}], "preferred_name": "IgM B lymphocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 75.54735764213513, "identifiers": [{"i": "UMLS:C1514108", "l": "Neoplastic T-Lymphoblast", "d": [], "t": []}, {"i": "NCIT:C37071", "l": "Neoplastic T-Lymphoblast", "d": [], "t": []}], "preferred_name": "Neoplastic T-Lymphoblast", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1440321", "l": "CD49a+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:1372898005", "l": "", "d": [], "t": []}], "preferred_name": "CD49a+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C6003402", "l": "HUMAN CORD BLOOD HEMATOPOIETIC PROGENITOR CELL 500000000 in 30 mL INTRAVENOUS LIQUID [Hematopoietic Progenitor Cells, Cord Blood]", "d": [], "t": []}], "preferred_name": "HUMAN CORD BLOOD HEMATOPOIETIC PROGENITOR CELL 500000000 in 30 mL INTRAVENOUS LIQUID [Hematopoietic Progenitor Cells, Cord Blood]", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0003033", "l": "M4 retinal ganglion cell", "d": ["A monostratified retinal ganglion cell that has a large soma, a medium dendritic field with post synaptic terminals in sublaminar layer S3."], "t": []}], "preferred_name": "M4 retinal ganglion cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C4329343", "l": "Anti-hCD70-CAR Retroviral Vector-transduced Autologous PBLs", "d": [], "t": []}, {"i": "NCIT:C129593", "l": "Anti-hCD70-CAR Retroviral Vector-transduced Autologous PBLs", "d": ["A preparation of autologous human peripheral blood lymphocytes (PBLs) transduced with a retroviral vector encoding for a T-cell chimeric antigen receptor (CAR) gene specific for the human cluster of differentiation 70 (CD70), with potential immunostimulatory and antineoplastic activities. Autologous PBLs from a patient with CD70-positive cancer are transduced with a retroviral vector that encodes the CAR gene specific for CD70. After expansion in culture and reintroduction into the patient, anti-hCD70-CAR retroviral vector-transduced autologous PBLs bind to the CD70 antigen on tumor cell surfaces; subsequently, CD70-expressing tumor cells are lysed. CD70, the ligand for the costimulatory receptor CD27, is overexpressed on the surfaces of various cancer cell types."], "t": []}], "preferred_name": "Anti-hCD70-CAR Retroviral Vector-transduced Autologous PBLs", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5175603", "l": "Other cells | Blood cord | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Other cells | Blood cord | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": 72.615132056446, "identifiers": [{"i": "UMLS:C1513753", "l": "Multipotent Bone Marrow Stem Cell", "d": [], "t": []}, {"i": "NCIT:C41058", "l": "Multipotent Bone Marrow Stem Cell", "d": ["A bone marrow myeloid stem cell that can differentiate into all the blood lineages."], "t": []}], "preferred_name": "Multipotent Bone Marrow Stem Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 80.61184433509295, "identifiers": [{"i": "CL:0000511", "l": "androgen binding protein secreting cell", "d": ["A peptide hormone secreting cell that secretes androgen binding protein."], "t": []}], "preferred_name": "androgen binding protein secreting cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C2323361", "l": "Midget cone bipolar cell", "d": [], "t": []}], "preferred_name": "Midget cone bipolar cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1440254", "l": "CD128+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:1372833003", "l": "", "d": [], "t": []}], "preferred_name": "CD128+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1515267", "l": "Tendinocyte", "d": [], "t": []}, {"i": "NCIT:C33747", "l": "Tendinocyte", "d": ["An elongated cell with invisible cytoplasm and flattened, poorly-stained, nucleus. It is found in the tendon and is positioned in a very regular pattern of rows between parallel bundles of collagen fibers. It makes up the fibers and ground substance of the tendon."], "t": []}], "preferred_name": "Tendinocyte", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1440277", "l": "CD28+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:732270008", "l": "", "d": [], "t": []}], "preferred_name": "CD28+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5171864", "l": "Macrophages | Body fluid | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Macrophages | Body fluid | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": 87.18682603146104, "identifiers": [{"i": "CL:0000377", "l": "tracheoblast", "d": [], "t": []}], "preferred_name": "tracheoblast", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5204822", "l": "Autologous HPV16 E7-specific HLA-A*02:01-restricted TCR Gene Engineered Lymphocytes KITE-439", "d": [], "t": []}, {"i": "NCIT:C159977", "l": "Autologous HPV16 E7-specific HLA-A*02:01-restricted TCR Gene Engineered Lymphocytes KITE-439", "d": ["A preparation of autologous T-lymphocytes that have been genetically modified to express a T-cell receptor (TCR) specific for the human leukocyte antigen (HLA)-A*02:01-restricted human papillomavirus type 16 isoform E7 protein (HPV16 E7) with potential antineoplastic activity. Upon isolation, transduction, expansion ex vivo and re-introduction into the patient, the autologous HPV16 E7-specific HLA-A*02:01-restricted T-lymphocytes KITE-439 target and bind HPV16 E7-expressing tumor cells. This may lead to cytotoxic T-lymphocyte (CTL)-mediated elimination of tumor cells expressing the HPV16 E7 antigen. HPV16 E7, a cell surface glycoprotein and tumor-associated antigen (TAA), is overexpressed in various HPV-mediated cancers."], "t": []}], "preferred_name": "Autologous HPV16 E7-specific HLA-A*02:01-restricted TCR Gene Engineered Lymphocytes KITE-439", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0002391", "l": "multinucleate blastoconidium", "d": ["A blastoconidium that has more than one nucleus."], "t": []}], "preferred_name": "multinucleate blastoconidium", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C4725094", "l": "EPS8 Peptide-specific Dendritic Cells", "d": [], "t": []}, {"i": "NCIT:C148518", "l": "EPS8 Peptide-specific Dendritic Cells", "d": ["A preparation of dendritic cells (DCs) pulsed with peptides derived from epidermal growth factor receptor (EGFR) pathway substrate 8 (EPS8), with potential immunostimulating and antineoplastic activities. Upon administration of the EPS8 peptide-specific DCs, the immune system is exposed to the EPS8 antigens. This results in the induction of a specific cytotoxic T-lymphocyte (CTL) response against EPS8-expressing tumor cells and tumor cell lysis. EPS8, a tumor-associated antigen (TAA), is overexpressed in a variety of tumor cell types but rarely in normal tissues. As a substrate for the EGFR kinase, it plays a key role in tumor progression through the EGFR-dependent pathway. Its expression is correlated with a poor prognosis."], "t": []}], "preferred_name": "EPS8 Peptide-specific Dendritic Cells", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5163730", "l": "Erythrocytes | Vaginal | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Erythrocytes | Vaginal | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0545061", "l": "May-Hegglin cell", "d": [], "t": []}], "preferred_name": "May-Hegglin cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:1001286", "l": "inner medulla vasa recta descending limb cell", "d": ["Any vasa recta descending limb cell that is part of some inner medulla descending vasa recta."], "t": []}], "preferred_name": "inner medulla vasa recta descending limb cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5706544", "l": "LYL 132", "d": [], "t": []}], "preferred_name": "LYL 132", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C0017527", "l": "Giant Cells, Foreign-Body", "d": [], "t": []}, {"i": "NCIT:C12561", "l": "Foreign Body Giant Cell", "d": ["An assemblage of macrophages that become fused in an inflammatory response to the presence of exogenous material."], "t": []}, {"i": "MESH:D015743", "l": "Giant Cells, Foreign-Body", "d": [], "t": []}, {"i": "SNOMEDCT:21386001", "l": "", "d": [], "t": []}], "preferred_name": "Giant Cells, Foreign-Body", "taxa": []}
{"type": "biolink:Cell", "ic": 69.94527858408269, "identifiers": [{"i": "CL:4023018", "l": "pvalb GABAergic cortical interneuron", "d": ["A transcriptomically distinct GABAergic interneuron with a soma located in the pallium. These neurons express Parvalbumin.", "A transcriptomically distinct GABAergic interneuron with a soma located in a cerebral cortex and it expresses Parvalbumin. The standard transcriptomic reference data for this cell type can be found on the CellxGene census under the collection: 'Transcriptomic cytoarchitecture reveals principles of human neocortex organization', dataset: 'Supercluster: MGE-derived interneurons', Author Categories: 'CrossArea_subclass', cluster Pvalb."], "t": []}], "preferred_name": "pvalb GABAergic cortical interneuron", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4310148", "l": "OB FRMD7 GABA GABAergic neuron (Primate)", "d": ["A GABAergic neuron of the Primates brain. These cells are located in the striatum . Reference transcriptomic data for this type can be found in the dataset/taxonomy - HMBA Basal Ganglia Consensus Taxonomy in cell set Group:OB FRMD7 GABA."], "t": []}], "preferred_name": "OB FRMD7 GABA GABAergic neuron (Primate)", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5417906", "l": "AMG-553", "d": [], "t": []}, {"i": "NCIT:C172197", "l": "Autologous Anti-FLT3 CAR T Cells AMG 553", "d": ["A preparation of autologous T-lymphocytes genetically engineered with a chimeric antigen receptor (CAR) specific for the tumor-associated antigen FMS-like tyrosine kinase 3 (FLT3; CD135; STK1; FLK2), with potential immunostimulating and antineoplastic activities. Upon administration, the anti-FLT3 CAR T cells AMG 553 target and bind to tumor cells expressing FLT3, which results in the cytotoxic T-lymphocyte (CTL)-mediated cell killing of FLT3-expressing tumor cells. FLT3, a class III receptor tyrosine kinase (RTK), is overexpressed or mutated in most B-lineage neoplasms and in acute myeloid leukemias (AMLs)."], "t": []}], "preferred_name": "AMG-553", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5708224", "l": "Autologous Tumor-infiltrating Lymphocytes-Central Memory T-cells", "d": [], "t": []}, {"i": "NCIT:C189071", "l": "Autologous Tumor-infiltrating Lymphocytes-Central Memory T-cells", "d": ["A preparation of autologous ex-vivo expanded central memory T (Tcm) cell-like tumor-infiltrating lymphocytes (TILs) derived from the patient's tumor tissue and peripheral blood, with potential immunostimulatory and antineoplastic activities. Upon isolation and ex-vivo treatment, the therapeutic ex-vivo-treated autologous TIL-Tcm cells, upon reintroduction into the patient, can activate an antitumor immune respone and eradicate tumor cells."], "t": []}], "preferred_name": "Autologous Tumor-infiltrating Lymphocytes-Central Memory T-cells", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4518164", "l": "Population of all spermatozoa with abnormal head in portion of fluid", "d": [], "t": []}, {"i": "SNOMEDCT:725222003", "l": "", "d": [], "t": []}], "preferred_name": "Population of all spermatozoa with abnormal head in portion of fluid", "taxa": []}
{"type": "biolink:Cell", "ic": 90.871710685482, "identifiers": [{"i": "CL:0002523", "l": "mesonephric podocyte", "d": ["A specialized epithelial cell that contains \"feet\" that interdigitate with the \"feet\" of other glomerular epithelial cells in the mesonephros."], "t": []}], "preferred_name": "mesonephric podocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 78.54651317367835, "identifiers": [{"i": "CL:0001034", "l": "cell in vitro", "d": ["A cell that is maintained or propagated in a controlled artificial environment for use in an investigation."], "t": []}], "preferred_name": "cell in vitro", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0009072", "l": "medullary thymic epithelial cell type 2", "d": ["A thymic medullary epithelial cell that expresses AIRE or other canonical markers of mature mTECs like Fezf2."], "t": []}], "preferred_name": "medullary thymic epithelial cell type 2", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0020002", "l": "mucosal-associated invariant T cell, human", "d": ["A mucosal-associated invariant T (MAIT) cell found in various tissues including human blood, liver, gut, and lung, characterised by a semi-invariant T cell receptor (TCR) comprising TRAV1-2 (Vα7.2) predominantly paired with TRAJ33, and high expression of CD161. Upon activation, MAIT cells produce inflammatory cytokines, including IFN-γ, TNF-α, and IL-17."], "t": []}], "preferred_name": "mucosal-associated invariant T cell, human", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5554748", "l": "Allogeneic Anti-CD70-CAR T-cells ALLO-316", "d": [], "t": []}, {"i": "NCIT:C177917", "l": "Allogeneic Anti-CD70-CAR T-cells ALLO-316", "d": ["An off-the-shelf (OTS) preparation of human allogeneic T-lymphocytes obtained from healthy donors that are engineered to express a chimeric antigen receptor (CAR) specific for the tumor-associated antigen (TAA) human cluster of differentiation 70 (CD70) and gene-edited with transcription activator-like effector nuclease (TALEN) to inactivate the endogenous T-cell receptor alpha constant (TRAC) and CD52 loci, with potential immunostimulating and antineoplastic activities. Upon introduction into the patient, the allogeneic anti-CD70-CAR T-cells ALLO-316 recognize and bind to CD70-expressing tumor cells. This may result in a specific cytotoxic T-lymphocyte (CTL)-mediated killing of CD70-positive tumor cells. CD70, a type II transmembrane glycoprotein and member of the tumor necrosis factor (TNF) family, is found on the surfaces of various types of cancer cells. Deletion of the CD52 gene makes the modified donor T-cells resistant to anti-CD52 monoclonal antibodies, which can be used during lymphodepletion. The deletion of the TRAC gene abrogates the potential induction of graft-versus-host disease (GvHD) by the donor T-cells."], "t": []}], "preferred_name": "Allogeneic Anti-CD70-CAR T-cells ALLO-316", "taxa": []}
{"type": "biolink:Cell", "ic": 92.76600187037766, "identifiers": [{"i": "CL:0002181", "l": "mucous neck cell of gastric gland", "d": ["A columnar epithelial mucous secreting cell located in the neck of the gastric glands. These cells have numerous apical secretory vesicles containing mucins and a basally displaced nucleus. The mucous they secrete is distinct histochemically from that of the surface mucous cells of stomach."], "t": []}, {"i": "UMLS:C1179476", "l": "Mucous cell of gastric gland", "d": [], "t": []}], "preferred_name": "mucous neck cell of gastric gland", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5939463", "l": "Epithelial cells.non-squamous|PrThr|Urine", "d": [], "t": []}], "preferred_name": "Epithelial cells.non-squamous|PrThr|Urine", "taxa": []}
{"type": "biolink:Cell", "ic": 77.38833137893549, "identifiers": [{"i": "CL:0000824", "l": "mature natural killer cell", "d": ["A natural killer cell that is developmentally mature and expresses a variety of inhibitory and activating receptors that recognize MHC class I and other stress related molecules."], "t": []}], "preferred_name": "mature natural killer cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1881195", "l": "Indium In 111-Labeled Autologous Peripheral Blood Mononuclear Cells", "d": [], "t": []}, {"i": "NCIT:C67085", "l": "Indium In 111-Labeled Autologous Peripheral Blood Mononuclear Cells", "d": ["A preparation of autologous peripheral blood mononuclear cells (PBMCs) radiolabeled with indium In 111 with radioisotopic activity. Autologous PBMCs are isolated, expanded ex vivo, radiolabeled with indium In 111, and then infused back into the patient. Gamma scintigraphy may then be used to image gamma ray-emitting indium In 111 PBMCs localized in lymphoma tissue."], "t": []}], "preferred_name": "Indium In 111-Labeled Autologous Peripheral Blood Mononuclear Cells", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C2981784", "l": "WT1 mRNA-Electroporated Autologous Dendritic Cell Vaccine", "d": [], "t": []}, {"i": "NCIT:C88260", "l": "WT1 mRNA-Electroporated Autologous Dendritic Cell Vaccine", "d": ["A cancer vaccine containing autologous dendritic cells electroporated with full-length mRNA encoding Wilms' tumor 1 (WT1) antigen with potential immunostimulatory and antineoplastic activities. Upon administration, WT1 mRNA-electroporated autologous dendritic cell vaccine may elicit a cytotoxic T-cell (CTL) response against tumor cells expressing WT1. Wt1 is frequently overexpressed in a variety of tumor cell types and often correlates with disease progression and poor prognosis."], "t": []}], "preferred_name": "WT1 mRNA-Electroporated Autologous Dendritic Cell Vaccine", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0333771", "l": "Coil/whorled fibers", "d": [], "t": []}], "preferred_name": "Coil/whorled fibers", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0682642", "l": "fixed or free macrophage", "d": [], "t": []}], "preferred_name": "fixed or free macrophage", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5854636", "l": "Anti-CLDN18.2 CAR-T Cells AZD6422", "d": [], "t": []}, {"i": "NCIT:C201144", "l": "Anti-CLDN18.2 CAR-T Cells AZD6422", "d": ["A preparation of T-lymphocytes that have been genetically modified to express a chimeric antigen receptor (CAR) targeting the tumor-associated antigen (TAA) Claudin18.2 (CLDN18.2; A2 isoform of claudin-18), with potential immunostimulating and antineoplastic activities. Upon administration, anti-CLDN18.2 CAR-T cells AZD6422 specifically recognize and bind to CLDN18.2-expressing tumor cells. This may result in a specific cytotoxic T-lymphocyte (CTL)-mediated killing of CLDN18.2-expressing tumor cells. CLDN18.2, a tight junction protein and stomach-specific isoform of claudin-18, is overexpressed on a variety of tumor cells, but its expression in healthy tissues is strictly confined to short-lived differentiated epithelial cells of the gastric mucosa."], "t": []}], "preferred_name": "Anti-CLDN18.2 CAR-T Cells AZD6422", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C1515314", "l": "Mouse Leydig Cell", "d": [], "t": []}, {"i": "NCIT:C22181", "l": "Mouse Leydig Cell", "d": [], "t": []}], "preferred_name": "Mouse Leydig Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 83.11065783093733, "identifiers": [{"i": "CL:4023079", "l": "midbrain-derived inhibitory neuron", "d": ["A GABAergic inhibitory neuron that is derived from the midbrain."], "t": []}], "preferred_name": "midbrain-derived inhibitory neuron", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0002637", "l": "keratinized epithelial cell of the anal canal", "d": ["An epithelial cell of the anal canal that is keratinized. This cell type is found towards the lower, rectal end of the anal canal."], "t": []}], "preferred_name": "keratinized epithelial cell of the anal canal", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0882833", "l": "CD3+CD4+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:732279009", "l": "", "d": [], "t": []}], "preferred_name": "CD3+CD4+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1267901", "l": "Lymphocyte positive for CD28 antigen", "d": [], "t": []}, {"i": "SNOMEDCT:117572009", "l": "", "d": [], "t": []}], "preferred_name": "Lymphocyte positive for CD28 antigen", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0000376", "l": "humidity receptor cell", "d": [], "t": []}], "preferred_name": "humidity receptor cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5157541", "l": "CD4+CD28+ cells | Blood | Cell markers", "d": [], "t": []}], "preferred_name": "CD4+CD28+ cells | Blood | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4322830", "l": "Bone marrow-derived hemopoietic stem cell", "d": [], "t": []}], "preferred_name": "Bone marrow-derived hemopoietic stem cell", "taxa": []}
{"type": "biolink:Cell", "ic": 92.76600187037766, "identifiers": [{"i": "CL:0000941", "l": "thymic conventional dendritic cell", "d": ["A dendritic cell arising in thymus that has the phenotype CD11c-positive, CD11b-negative, and CD45RA-negative."], "t": []}], "preferred_name": "thymic conventional dendritic cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1267859", "l": "Lymphocyte positive for both CD8 antigen and HLA-DR antigen", "d": [], "t": []}, {"i": "SNOMEDCT:116815002", "l": "", "d": [], "t": []}], "preferred_name": "Lymphocyte positive for both CD8 antigen and HLA-DR antigen", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5220581", "l": "Erythrocytes|Urine/Urine sed", "d": [], "t": []}], "preferred_name": "Erythrocytes|Urine/Urine sed", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5238118", "l": "Adimlecleucel", "d": [], "t": []}, {"i": "NCIT:C166763", "l": "Adimlecleucel", "d": [], "t": []}], "preferred_name": "Adimlecleucel", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0002500", "l": "P enteroendocrine cell", "d": ["A P/D1 enteroendocrine cell that is Grimelius positive and stores bombesin-like polypeptide."], "t": []}, {"i": "UMLS:C2338609", "l": "Type P enteroendocrine cell", "d": [], "t": []}], "preferred_name": "P enteroendocrine cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0000969", "l": "regulatory B cell", "d": ["A mature B cell that has the phenotype CD1d-positive and expresses interleukin-10. This cell type has been associated with suppression of chronic inflammatory responses and T cell responses."], "t": []}, {"i": "UMLS:C3178914", "l": "B-Lymphocytes, Regulatory", "d": [], "t": []}, {"i": "NCIT:C113502", "l": "Regulatory B Cell", "d": ["A subset of B-cells that can negatively regulate immune responses mediated by T-cells. These B-lymphocytes produce interleukin-10."], "t": []}, {"i": "MESH:D060151", "l": "B-Lymphocytes, Regulatory", "d": [], "t": []}], "preferred_name": "regulatory B cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0020049", "l": "intestinofugal neuron", "d": ["An enteric neuron whose soma resides in the myenteric plexus of the intestine and whose axon projects outside the gut wall to synapse on neurons in prevertebral sympathetic ganglia (celiac, superior mesenteric, or inferior mesenteric ganglia). This neuron provides a pathway for gut-to-brain communication via sympathetic prevertebral ganglia. In humans, 89% are immunopositive for choline acetyltransferase (ChAT); CART (cocaine- and amphetamine-regulated transcript) is NOT a human marker (0% CART+) but is present in rodent viscerofugal neurons."], "t": []}], "preferred_name": "intestinofugal neuron", "taxa": []}
{"type": "biolink:Cell", "ic": 92.76600187037766, "identifiers": [{"i": "CL:4023125", "l": "KNDy neuron", "d": ["A hypothalamus kisspeptin neuron that coexpresses kisspeptin, neurokinin B and dynorphin."], "t": []}], "preferred_name": "KNDy neuron", "taxa": []}
{"type": "biolink:Cell", "ic": 70.37024337467663, "identifiers": [{"i": "UMLS:C0225338", "l": "Columnar epithelial cell", "d": [], "t": []}, {"i": "NCIT:C13158", "l": "Columnar Cell", "d": ["An epithelial cell that is taller than it is wide. The nucleus is oval, usually situated at the base of the cell. These cells line large glands and ducts."], "t": []}, {"i": "SNOMEDCT:6032003", "l": "", "d": [], "t": []}], "preferred_name": "Columnar epithelial cell", "taxa": []}
{"type": "biolink:Cell", "ic": 90.871710685482, "identifiers": [{"i": "CL:0020046", "l": "intrinsic primary afferent neuron of myenteric plexus", "d": ["A sensory neuron of the enteric nervous system whose soma resides in the myenteric plexus and which functions as the afferent limb of intrinsic reflex circuits controlling motility, secretion, and blood flow. This neuron is characterised by Dogiel type II morphology (large smooth soma with multiple long axon-like processes), AH-type electrophysiology (prolonged afterhyperpolarization following an action potential), and is immunopositive for choline acetyltransferase (ChAT) and immunonegative for neuronal nitric oxide synthase (NOS1)."], "t": []}], "preferred_name": "intrinsic primary afferent neuron of myenteric plexus", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5853919", "l": "a fourth generation activating chimeric receptor (ACR) natural killer (NK) cell therapy engineered with an NKG2D ACR, OX40 costimulatory domain, CD3zeta signaling moiety, and membrane bound IL-15 (mb-IL15)", "d": [], "t": []}], "preferred_name": "a fourth generation activating chimeric receptor (ACR) natural killer (NK) cell therapy engineered with an NKG2D ACR, OX40 costimulatory domain, CD3zeta signaling moiety, and membrane bound IL-15 (mb-IL15)", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0000720", "l": "anterior cone cell (sensu Endopterygota)", "d": [], "t": []}], "preferred_name": "anterior cone cell (sensu Endopterygota)", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5157529", "l": "CD3-CD57+ cells | Tissue and Smears | Cell markers", "d": [], "t": []}], "preferred_name": "CD3-CD57+ cells | Tissue and Smears | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": 88.20185721311867, "identifiers": [{"i": "CL:0000776", "l": "immature neutrophil", "d": ["Any of the immature forms of a neutrophil in which neutrophilic specific granules are present but other phenotypic features of the mature form may be lacking."], "t": []}], "preferred_name": "immature neutrophil", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1317735", "l": "Agglutinated spermatozoa", "d": [], "t": []}, {"i": "SNOMEDCT:726593007", "l": "", "d": [], "t": []}], "preferred_name": "Agglutinated spermatozoa", "taxa": []}
{"type": "biolink:Cell", "ic": 88.20185721311867, "identifiers": [{"i": "UMLS:C1518267", "l": "Mouse Neuroblast", "d": [], "t": []}, {"i": "NCIT:C22630", "l": "Mouse Neuroblast", "d": [], "t": []}], "preferred_name": "Mouse Neuroblast", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0000544", "l": "slowly adapting mechanoreceptor cell", "d": [], "t": []}], "preferred_name": "slowly adapting mechanoreceptor cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5163731", "l": "Erythrocytes | Vitreous fluid | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Erythrocytes | Vitreous fluid | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": 90.871710685482, "identifiers": [{"i": "CL:0002670", "l": "type I spiral ligament fibrocyte", "d": ["A spiral ligament fibrocyte that underlies the stria vascularis and is part of a mesenchymal gap junction network that regulates ionic homeostasis of the endolymph. In mice, expression of connexin 26 (Gjb2) and connexin 30 (Gjb6) serves as a distinguishing molecular signature."], "t": []}], "preferred_name": "type I spiral ligament fibrocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4033135", "l": "inferior mesenteric ganglion TH neuron", "d": ["A sympathetic neuron that has the soma located in the inferior mesenteric ganglion and expresses the marker tyrosine hydroxylase (TH)."], "t": []}], "preferred_name": "inferior mesenteric ganglion TH neuron", "taxa": []}
{"type": "biolink:Cell", "ic": 80.61184433509295, "identifiers": [{"i": "CL:0007003", "l": "preodontoblast", "d": ["Skeletogenic cell that has the potential to form an odontoblast, deposits predentine, and arises from a cranial neural crest cell."], "t": []}], "preferred_name": "preodontoblast", "taxa": []}
{"type": "biolink:Cell", "ic": 88.20185721311867, "identifiers": [{"i": "CL:0000852", "l": "neuromast supporting cell", "d": ["Neuromast support cell is a non-sensory cell of the neuromast that extend between the sensory hair cells from the basement membrane to the apical surface; neuromast support cells are surrounded by neuromast mantle cells."], "t": []}], "preferred_name": "neuromast supporting cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0000406", "l": "CNS short range interneuron", "d": [], "t": []}], "preferred_name": "CNS short range interneuron", "taxa": []}
{"type": "biolink:Cell", "ic": 92.76600187037766, "identifiers": [{"i": "CL:0002044", "l": "Kit-positive, integrin beta7-high basophil mast progenitor cell", "d": ["A basophil mast progenitor cell that is Beta-7 integrin-high, Kit-positive FcRgammaII/III-positive and Sca1-negative."], "t": []}], "preferred_name": "Kit-positive, integrin beta7-high basophil mast progenitor cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0312737", "l": "Immunologic cell", "d": [], "t": []}, {"i": "SNOMEDCT:64419002", "l": "", "d": [], "t": []}], "preferred_name": "Immunologic cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0009056", "l": "transit amplifying cell of anorectum", "d": ["A transit amplifying cell that is located in the anorectum."], "t": []}], "preferred_name": "transit amplifying cell of anorectum", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C4086003", "l": "Autologous CEA-specific Cytotoxic T-lymphocytes", "d": [], "t": []}, {"i": "NCIT:C123822", "l": "Autologous CEA-specific Cytotoxic T-lymphocytes", "d": ["Autologous cytotoxic T-lymphocytes (CTLs) specifically reactive to the tumor-associated antigen (TAA) human carcinoembryonic antigen (CEA), with potential antineoplastic activity. Dendritic cells (DCs) isolated from the patient's blood are infected with recombinant adeno-associated virus (AAV) expressing the CEA gene. Exposure of T-lymphocytes to DCs creates CEA-specific CTLs which are expanded. Upon reintroduction of these CTLs into the patient, these cells recognize and kill CEA-expressing tumor cells. CEA, a tumor-associated antigen and a member of the CEA family of proteins, plays a key role in cell migration, cell invasion, and cell adhesion and is overexpressed by a variety of cancer types."], "t": []}], "preferred_name": "Autologous CEA-specific Cytotoxic T-lymphocytes", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0002626", "l": "immature astrocyte", "d": ["An immature astrocyte."], "t": []}], "preferred_name": "immature astrocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:1000362", "l": "transitional myocyte of interventricular septum", "d": ["A transitional myocyte that is part of the interventricular septum."], "t": []}, {"i": "UMLS:C2325226", "l": "Transitional myocyte of interventricular septum", "d": [], "t": []}], "preferred_name": "transitional myocyte of interventricular septum", "taxa": []}
{"type": "biolink:Cell", "ic": 83.11065783093733, "identifiers": [{"i": "UMLS:C1514173", "l": "Pleomorphic Lipoblast", "d": [], "t": []}, {"i": "NCIT:C36974", "l": "Pleomorphic Lipoblast", "d": [], "t": []}], "preferred_name": "Pleomorphic Lipoblast", "taxa": []}
{"type": "biolink:Cell", "ic": 75.876659701315, "identifiers": [{"i": "CL:0000656", "l": "primary spermatocyte", "d": ["A diploid cell that has derived from a spermatogonium and can subsequently begin meiosis and divide into two haploid secondary spermatocytes."], "t": []}], "preferred_name": "primary spermatocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0003023", "l": "retinal ganglion cell C6", "d": ["A retinal ganglion cell C outer that has dense dendritic diversity."], "t": []}], "preferred_name": "retinal ganglion cell C6", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "CL:4030052", "l": "nucleus accumbens shell and olfactory tubercle D2 medium spiny neuron", "d": ["A DRD2-expressing medium spiny neuron that is part of a nucleus accumbens shell or olfactory tubercle."], "t": []}], "preferred_name": "nucleus accumbens shell and olfactory tubercle D2 medium spiny neuron", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C4329309", "l": "Anti-ACTR/4-1BB/CD3zeta-Viral Vector-transduced Autologous T-Lymphocytes ACTR087", "d": [], "t": []}, {"i": "NCIT:C129715", "l": "Anti-ACTR/4-1BB/CD3zeta-Viral Vector-transduced Autologous T-Lymphocytes ACTR087", "d": ["Autologous T-lymphocytes that are genetically modified and transfected with a viral vector expressing the ACTR gene, a proprietary gene encoding for an antibody-coupled T-cell receptor (ATCR), with potential antineoplastic activity. The ACTR contains the extracellular Fc receptor CD16 domain, normally found on certain immune cells, such as natural killer (NK) cells, coupled to the co-immunostimulatory signaling domain 4-1BB, normally expressed on T-cells, and linked to the intracellular CD3 zeta domain (CD3z), which is needed for TCR signaling. Upon reintroduction into the patient and co-administration of a cancer-specific antibody, the co-administered antibody targets and binds to the tumor-associated antigen (TAA) expressed on the tumor cell. In turn, this induces the activation of the ACTR087 cells and destruction of the tumor cells by a) releasing cytotoxins that directly kill cancer cells; b) releasing cytokines that trigger an immune response and recruit other immune-mediated killer cells to kill the tumor cells; b) targeting and killing adjacent tumor cells that are not bound to the antibody; c) inducing T-cell proliferation and thereby further enhancing the T-cell mediated tumor cell attack. CD3 zeta is one of several membrane-bound polypeptides found in the TCR/CD3 complex; it enhances the survival and persistence of T-lymphocytes. The 4-1BB co-stimulatory molecule signaling domain enhances activation and signaling after recognition of the TAA."], "t": []}], "preferred_name": "Anti-ACTR/4-1BB/CD3zeta-Viral Vector-transduced Autologous T-Lymphocytes ACTR087", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5163712", "l": "Erythrocytes | Bronchoalveolar lavage | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Erythrocytes | Bronchoalveolar lavage | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C2340574", "l": "Horizontal cell of cerebral cortex", "d": [], "t": []}], "preferred_name": "Horizontal cell of cerebral cortex", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5669239", "l": "Allogeneic Anti-CD5 CAR T Cells", "d": [], "t": []}, {"i": "NCIT:C184378", "l": "Allogeneic Anti-CD5 CAR T Cells", "d": ["A preparation of allogeneic T-lymphocytes that have been genetically modified to express a chimeric antigen receptor (CAR) specific for CD5, with potential immunomodulating and antineoplastic activities. Upon administration, the allogeneic anti-CD5 CAR T cells target and bind to CD5-expressing tumor cells, thereby inducing selective cytotoxicity in CD5-expressing tumor cells. CD5 is a T-cell surface glycoprotein expressed on the surface of normal T-cells and overexpressed on various B- and T-cell malignancies."], "t": []}], "preferred_name": "Allogeneic Anti-CD5 CAR T Cells", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4267788", "l": "CD27-IgD+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:1373175009", "l": "", "d": [], "t": []}], "preferred_name": "CD27-IgD+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": 68.3133595125128, "identifiers": [{"i": "CL:0000818", "l": "transitional stage B cell", "d": ["An immature B cell of an intermediate stage between the pre-B cell stage and the mature naive stage with the phenotype surface IgM-positive and CD19-positive, and are subject to the process of B cell selection. A transitional B cell migrates from the bone marrow into the peripheral circulation, and then to the spleen."], "t": []}], "preferred_name": "transitional stage B cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0000947", "l": "IgE plasma cell", "d": ["A long lived plasma cell that secretes IgE."], "t": []}], "preferred_name": "IgE plasma cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:1000285", "l": "smooth muscle cell of sigmoid colon", "d": ["A smooth muscle cell that is part of the sigmoid colon."], "t": []}, {"i": "UMLS:C0736251", "l": "Smooth muscle fiber of sigmoid colon", "d": [], "t": []}], "preferred_name": "smooth muscle cell of sigmoid colon", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0002059", "l": "CD8-alpha-positive thymic conventional dendritic cell", "d": ["A conventional thymic dendritic cell that is CD8-alpha-positive."], "t": []}], "preferred_name": "CD8-alpha-positive thymic conventional dendritic cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1719198", "l": "CD20+CD52+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:1372995007", "l": "", "d": [], "t": []}], "preferred_name": "CD20+CD52+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5908950", "l": "Sitocabnagene Loxiveleucel", "d": [], "t": []}], "preferred_name": "Sitocabnagene Loxiveleucel", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "CL:4042032", "l": "PAX6 GABAergic interneuron", "d": ["A transcriptomically distinct GABAergic neuron, located in the cerebral cortex and derived from the CGE, that expresses the transcript PAX6."], "t": []}], "preferred_name": "PAX6 GABAergic interneuron", "taxa": []}
{"type": "biolink:Cell", "ic": 74.37365206292206, "identifiers": [{"i": "CL:0000561", "l": "amacrine cell", "d": ["Interneuron of the vertebrate retina. They integrate, modulate, and interpose a temporal domain in the visual message presented to the retinal ganglion cells, with which they synapse in the inner plexiform layer. They lack large axons."], "t": []}, {"i": "UMLS:C0229216", "l": "Amacrine Cells", "d": [], "t": []}, {"i": "NCIT:C12626", "l": "Amacrine Cell", "d": ["A retinal neuron that lacks large axons, having only processes that resemble dendrites."], "t": []}, {"i": "MESH:D025042", "l": "Amacrine Cells", "d": [], "t": []}, {"i": "SNOMEDCT:9475001", "l": "", "d": [], "t": []}], "preferred_name": "amacrine cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1979078", "l": "Blasts.CD117", "d": [], "t": []}], "preferred_name": "Blasts.CD117", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "MESH:D034101", "l": "Sporozoites", "d": [], "t": []}], "preferred_name": "Sporozoites", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "UMLS:C1519373", "l": "Goblet cell of small intestine", "d": [], "t": []}, {"i": "NCIT:C33567", "l": "Small Intestinal Goblet Cell", "d": ["A unicellular mucous cell found in the epithelium of the small intestine. Droplets of mucigen collect in the upper part of the cell and distend it, while the basal end remains slender, and the cell assumes the shape of a goblet."], "t": []}], "preferred_name": "Goblet cell of small intestine", "taxa": []}
{"type": "biolink:Cell", "ic": 83.11065783093733, "identifiers": [{"i": "CL:0020030", "l": "CD4-positive exhausted alpha-beta T cell", "d": ["A CD4-positive alpha-beta T cell that displays impaired function and altered differentiation as a result of chronic antigenic stimulation (e.g., chronic infection, tumors, or persistent inflammation). This state is characterised by sustained expression of PD-1 as a shared feature. Additional exhaustion-associated molecules, including the transcription factor TOX, and context- or stage-dependent changes in markers such as LAG-3, TIM-3, CD39, and T-bet, may also be observed; however, the expression levels of these molecules vary depending on exhaustion stage and tissue environment."], "t": []}], "preferred_name": "CD4-positive exhausted alpha-beta T cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C2328697", "l": "Hemal cell", "d": [], "t": []}], "preferred_name": "Hemal cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C4727549", "l": "Autologous AXL-targeted CAR T-cells CCT301-38", "d": [], "t": []}, {"i": "NCIT:C154276", "l": "Autologous AXL-targeted CAR T-cells CCT301-38", "d": ["A preparation of genetically modified autologous T-lymphocytes transduced with a lentiviral vector to express a chimeric antigen receptor (CAR) targeting the receptor tyrosine kinase (RTK) AXL, with potential immunomodulatory and antineoplastic activities. After isolation, transduction, and expansion in culture, the CCT301-38 cells are reintroduced into the patient and are activated within the tumor microenvironment (TME) using proprietary Conditionally Active Biologic (CAB) technology. Upon activation, CAB antibodies bind to a proprietary T-cell signaling domain, promoting T-cell recognition and killing of AXL-expressing tumor cells. AXL is a RTK and oncogene that is overexpressed in many cancer types and is involved in the stimulation of tumor cell proliferation."], "t": []}], "preferred_name": "Autologous AXL-targeted CAR T-cells CCT301-38", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1979635", "l": "Blasts.CD11b", "d": [], "t": []}], "preferred_name": "Blasts.CD11b", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4518147", "l": "Population of all spermatozoa with cytoplasmic droplet in portion of fluid", "d": [], "t": []}, {"i": "SNOMEDCT:725252006", "l": "", "d": [], "t": []}], "preferred_name": "Population of all spermatozoa with cytoplasmic droplet in portion of fluid", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5707291", "l": "Autologous IL-15-expanded HER2-specific CD4+ T-cells", "d": [], "t": []}, {"i": "NCIT:C187685", "l": "Autologous IL-15-expanded HER2-specific CD4+ T-cells", "d": ["A preparation of autologous, interleukin-15 (IL-15)-expanded, human epidermal growth factor receptor 2 (EGFR2; HER2; ErbB2)-specific, cluster of differentiation 4 (CD4)-positive T-lymphocytes, with potential immunostimulating and antineoplastic activities. Autologous HER2-specific CD4+ T-cells are expanded ex vivo with IL-15. Upon reintroduction into the patient, the autologous IL-15-expanded HER2-specific CD4+ T-cells recognize and stimulate a T-cell-mediated immune response against HER2-expressing tumor cells. HER2, a receptor tyrosine kinase (RTK) mutated or overexpressed in many tumor cell types, plays a key role in tumor cell proliferation and tumor vascularization. IL-15 is a cytokine that enhances T-cell expansion."], "t": []}], "preferred_name": "Autologous IL-15-expanded HER2-specific CD4+ T-cells", "taxa": []}
{"type": "biolink:Cell", "ic": 66.96287368193121, "identifiers": [{"i": "CL:0000311", "l": "keratin accumulating cell", "d": [], "t": []}], "preferred_name": "keratin accumulating cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0009047", "l": "macrophage of medullary sinus of lymph node", "d": ["A macrophage found in the medullary sinus of the lymph node."], "t": []}], "preferred_name": "macrophage of medullary sinus of lymph node", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "UMLS:C1513370", "l": "MizMedi ES Cell Line", "d": [], "t": []}, {"i": "NCIT:C20278", "l": "MizMedi ES Cell Line", "d": [], "t": []}], "preferred_name": "MizMedi ES Cell Line", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0001646", "l": "Adrenergic Fibers", "d": [], "t": []}, {"i": "MESH:D000320", "l": "Adrenergic Fibers", "d": [], "t": []}, {"i": "SNOMEDCT:361060001", "l": "", "d": [], "t": []}], "preferred_name": "Adrenergic Fibers", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0000688", "l": "perijunctional fibroblast", "d": ["A fibroblast-like cell that provides support at neuromuscular junctions in vertebrates and are localized outside the synaptic basal lamina."], "t": []}], "preferred_name": "perijunctional fibroblast", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C2334011", "l": "Wandering histiocyte", "d": [], "t": []}], "preferred_name": "Wandering histiocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 53.156954713108284, "identifiers": [{"i": "CL:0000071", "l": "blood vessel endothelial cell", "d": ["An endothelial cell that lines the vasculature."], "t": []}], "preferred_name": "blood vessel endothelial cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5417884", "l": "Autologous Anti-CD19 TAC-T cells TAC01-CD19", "d": [], "t": []}, {"i": "NCIT:C172055", "l": "Autologous Anti-CD19 TAC-T cells TAC01-CD19", "d": ["A preparation of autologous T-lymphocytes genetically engineered with a T cell Antigen Coupler (TAC), comprising of a domain that targets the tumor-associated antigen (TAA) cluster of differentiation 19 (CD 19) and another domain that binds to the endogenous T cell receptor (TCR), anchored in the membrane via the CD4 co-receptor domain, with potential immunostimulating and antineoplastic activities. Upon administration, autologous anti-CD19 TAC-T cells TAC01-CD19 targets and binds to CD19-expressing tumor cells and activates TCR-mediated signaling pathways, leading to T cell-mediated killing of CD19-expressing tumor cells. CD19 antigen is a B-cell specific cell surface antigen overexpressed in B-cell lineage malignancies."], "t": []}], "preferred_name": "Autologous Anti-CD19 TAC-T cells TAC01-CD19", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5708220", "l": "Anti-CD19/Anti-CD70 4SCAR-expressing Bispecific T-cells", "d": [], "t": []}, {"i": "NCIT:C189058", "l": "Anti-CD19/Anti-CD70 4SCAR-expressing Bispecific T-cells", "d": ["A preparation of T-lymphocytes that are genetically engineered to express a fourth-generation chimeric antigen receptor (4SCAR) targeting the two tumor-associated antigens (TAAs) CD19 and CD70 (CD27 ligand; tumor necrosis factor superfamily member 7; TNFSF7), with potential immunostimulating and antineoplastic activities. Upon administration, the anti-CD19/anti-CD70 4SCAR-expressing bispecific T-cells are directed to and induce selective toxicity in CD19- and CD70-expressing tumor cells. CD19 antigen is a B-cell specific cell surface antigen expressed in all B-cell lineage malignancies. CD70, a cytokine belonging to the tumor necrosis superfamily (TNFSF) and the ligand for the costimulatory receptor CD27, is expressed on the surfaces of various types of cancer cells; its overexpression may play an important role in the evasion of immune surveillance. CD19 and CD70 are expressed at high levels on tumor cells but not at significant levels on normal tissues. Targeting two antigens may protect against antigen escape and may enhance CAR-T cell efficacy."], "t": []}], "preferred_name": "Anti-CD19/Anti-CD70 4SCAR-expressing Bispecific T-cells", "taxa": []}
{"type": "biolink:Cell", "ic": 68.3133595125128, "identifiers": [{"i": "UMLS:C0596993", "l": "Myeloid Progenitor Cells", "d": [], "t": []}, {"i": "NCIT:C12552", "l": "Bone Marrow Myeloid Stem Cell", "d": ["A hematopoietic stem cell found in the bone marrow that is committed to form erythrocytes, megakaryocytes, and all leukocytes except lymphocytes."], "t": []}, {"i": "MESH:D023461", "l": "Myeloid Progenitor Cells", "d": [], "t": []}], "preferred_name": "Myeloid Progenitor Cells", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C3641794", "l": "Gene-Modified HIV-Protected Hematopoietic Stem Cells", "d": [], "t": []}, {"i": "NCIT:C104415", "l": "Gene-Modified HIV-Protected Hematopoietic Stem Cells", "d": ["Autologous hematopoietic stem cells (HSCs) genetically modified to be resistant to infection by human immunodeficiency virus (HIV). Allogeneic human autologous HSCs are isolated and transduced ex vivo with three different anti-HIV genes. Upon infusion into the HIV-infected lymphoma patient, the gene-modified HIV-protected HSCs are resistant to HIV entry and replication thereby preventing HIV infection in these proliferating stem cells and any differentiated cells that they give rise to. This results in the formation of immune cells resistant to HIV which also may be able to destroy HIV-infected cells."], "t": []}], "preferred_name": "Gene-Modified HIV-Protected Hematopoietic Stem Cells", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1267818", "l": "Lymphocyte positive for both CD3 antigen and CD25 antigen", "d": [], "t": []}, {"i": "SNOMEDCT:116856004", "l": "", "d": [], "t": []}], "preferred_name": "Lymphocyte positive for both CD3 antigen and CD25 antigen", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4033072", "l": "cycling gamma-delta T cell", "d": ["A(n) gamma-delta T cell that is cycling."], "t": []}], "preferred_name": "cycling gamma-delta T cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0002271", "l": "type EC1 enteroendocrine cell", "d": ["A type EC enteredocrine cell in the intestines that stores and secretes substance P and 5-hydroxytryptamine."], "t": []}, {"i": "UMLS:C2323033", "l": "Type EC1 enteroendocrine cell", "d": [], "t": []}], "preferred_name": "type EC1 enteroendocrine cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5571779", "l": "Siderocytes.Type 1", "d": [], "t": []}], "preferred_name": "Siderocytes.Type 1", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4307041", "l": "Astro-TE NN_1 Jph4 astrocyte (Mmus)", "d": ["A astrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Myoc (Mmus), Sptbn2 (Mmus), Alpk1 (Mmus). It is distinguished from other Astro-TE NN_1 cells by expression of Myoc, Jph4, Alpk1. It is glutamatergic. These cells are located in the Isocortex, brain . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5221 Astro-TE NN_1.", "A astrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Myoc (Mmus), Sptbn2 (Mmus), Alpk1 (Mmus). It is distinguished from other Astro-TE NN_1 cells by expression of Myoc, Jph4, Alpk1. It is glutamatergic (inferred from expression of Aldh1a1, Slc17a7). These cells are located in the Isocortex, brain . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5221 Astro-TE NN_1."], "t": []}], "preferred_name": "Astro-TE NN_1 Jph4 astrocyte (Mmus)", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5706862", "l": "Equecabtagene autoleucel", "d": [], "t": []}], "preferred_name": "Equecabtagene autoleucel", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4307099", "l": "NFOL NN_2 Dbx2 newly formed oligodendrocyte (Mmus)", "d": ["A newly formed oligodendrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of 9630013A20Rik (Mmus), Dbx2 (Mmus), Rassf10 (Mmus). It is distinguished from other NFOL NN_2 cells by expression of Dbx2, Rassf10. These cells are located in the Isocortex, brain . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5279 NFOL NN_2."], "t": []}], "preferred_name": "NFOL NN_2 Dbx2 newly formed oligodendrocyte (Mmus)", "taxa": []}
{"type": "biolink:Cell", "ic": 70.01422862627324, "identifiers": [{"i": "CL:0008003", "l": "somatic muscle myotube", "d": ["A myotube that is part of some somatic muscle.  Examples include arthropod somatic muscle cells."], "t": []}], "preferred_name": "somatic muscle myotube", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C6063338", "l": "CD27+IgD+IgM+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:1373160001", "l": "", "d": [], "t": []}], "preferred_name": "CD27+IgD+IgM+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "UMLS:C0027625", "l": "Circulating Neoplastic Cells", "d": [], "t": []}, {"i": "NCIT:C63797", "l": "Circulating Tumor Cell", "d": ["A metastatic cancer cell found in the peripheral blood."], "t": []}, {"i": "MESH:D009360", "l": "Neoplastic Cells, Circulating", "d": [], "t": []}], "preferred_name": "Circulating Neoplastic Cells", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0014802", "l": "Erythroid Precursor Cells", "d": [], "t": []}, {"i": "MESH:D015672", "l": "Erythroid Precursor Cells", "d": [], "t": []}, {"i": "SNOMEDCT:304601009", "l": "", "d": [], "t": []}], "preferred_name": "Erythroid Precursor Cells", "taxa": []}
{"type": "biolink:Cell", "ic": 92.76600187037766, "identifiers": [{"i": "CL:0002412", "l": "Vgamma1.1-positive, Vdelta6.3-positive thymocyte", "d": ["A gamma-delta receptor that expresses Vgamma1.1-Vdelta6.3 chains in the T-cell receptor."], "t": []}], "preferred_name": "Vgamma1.1-positive, Vdelta6.3-positive thymocyte", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4512367", "l": "Entire glia", "d": [], "t": []}, {"i": "SNOMEDCT:727123002", "l": "", "d": [], "t": []}], "preferred_name": "Entire glia", "taxa": []}
{"type": "biolink:Cell", "ic": 69.87704306295657, "identifiers": [{"i": "UMLS:C1519778", "l": "Undifferentiated Carcinoma Cell", "d": [], "t": []}, {"i": "NCIT:C37085", "l": "Undifferentiated Carcinoma Cell", "d": [], "t": []}], "preferred_name": "Undifferentiated Carcinoma Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C4727117", "l": "Hematopoietic Immune Cell", "d": [], "t": []}, {"i": "NCIT:C153245", "l": "Hematopoietic Immune Cell", "d": ["A population of cells involved in the formation of blood cells and in host defense."], "t": []}], "preferred_name": "Hematopoietic Immune Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 88.20185721311867, "identifiers": [{"i": "CL:0000593", "l": "androgen secreting cell", "d": ["A steroid hormone secreting cell that secretes androgen."], "t": []}], "preferred_name": "androgen secreting cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1440298", "l": "CD34+HLA-DR+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:1373276000", "l": "", "d": [], "t": []}], "preferred_name": "CD34+HLA-DR+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4023053", "l": "spinal interneuron synapsing Betz cell", "d": ["A Betz cell that syanpses with spinal interneurons."], "t": []}], "preferred_name": "spinal interneuron synapsing Betz cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0002627", "l": "mature astrocyte", "d": ["A mature astrocyte that is capable of producing cytokines."], "t": []}], "preferred_name": "mature astrocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 72.8241867216765, "identifiers": [{"i": "UMLS:C1882047", "l": "Neoplastic Epithelial Cell with Eosinophilic Cytoplasm", "d": [], "t": []}, {"i": "NCIT:C61295", "l": "Neoplastic Epithelial Cell with Eosinophilic Cytoplasm", "d": [], "t": []}], "preferred_name": "Neoplastic Epithelial Cell with Eosinophilic Cytoplasm", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4518162", "l": "Population of all immature spermatozoa in portion of fluid", "d": [], "t": []}, {"i": "SNOMEDCT:725438007", "l": "", "d": [], "t": []}], "preferred_name": "Population of all immature spermatozoa in portion of fluid", "taxa": []}
{"type": "biolink:Cell", "ic": 76.5892103226413, "identifiers": [{"i": "CL:0000650", "l": "mesangial cell", "d": ["A cell type that encapsulates the capillaries and venules in the kidney. This cell secretes mesangial matrix that provides the structural support for the capillaries."], "t": []}, {"i": "UMLS:C0227651", "l": "Mesangial Cells, Kidney", "d": [], "t": []}, {"i": "NCIT:C13159", "l": "Mesangial Cell", "d": ["Cell found within the glomerular lobules of mammalian kidney. Mesangial cells serve as structural supports, may regulate blood flow, are phagocytic and may act as accessory cells, presenting antigen in immune responses."], "t": []}, {"i": "MESH:D050527", "l": "Mesangial Cells", "d": [], "t": []}, {"i": "SNOMEDCT:24259000", "l": "", "d": [], "t": []}], "preferred_name": "mesangial cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5157367", "l": "CD2 blasts | XXX | Cell markers", "d": [], "t": []}], "preferred_name": "CD2 blasts | XXX | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5216277", "l": "Monocytes|NCnc|Pt|Synv fld", "d": [], "t": []}], "preferred_name": "Monocytes|NCnc|Pt|Synv fld", "taxa": []}
{"type": "biolink:Cell", "ic": 53.61737591187899, "identifiers": [{"i": "CL:0000325", "l": "stuff accumulating cell", "d": ["A cell that is specialised to accumulate a particular substance(s)."], "t": []}], "preferred_name": "stuff accumulating cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0002606", "l": "astrocyte of the spinal cord", "d": ["An astrocyte of the spinal cord."], "t": []}], "preferred_name": "astrocyte of the spinal cord", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C6049737", "l": "Naive/Stem Cell Memory T-cells", "d": [], "t": []}, {"i": "NCIT:C215197", "l": "Naive/Stem Cell Memory T-cells", "d": ["A preparation of naive (Tnaive) and stem cell memory T-cells (Tscm)."], "t": []}], "preferred_name": "Naive/Stem Cell Memory T-cells", "taxa": []}
{"type": "biolink:Cell", "ic": 92.76600187037766, "identifiers": [{"i": "CL:1001068", "l": "kidney venous system smooth muscle cell", "d": [], "t": []}], "preferred_name": "kidney venous system smooth muscle cell", "taxa": []}
{"type": "biolink:Cell", "ic": 88.20185721311867, "identifiers": [{"i": "CL:0002381", "l": "uninucleate conidium", "d": ["A conidium that has only one nucleus."], "t": []}], "preferred_name": "uninucleate conidium", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4511162", "l": "Blast cell positive for cytoplasmic CD22 antigen", "d": [], "t": []}, {"i": "SNOMEDCT:725482003", "l": "", "d": [], "t": []}], "preferred_name": "Blast cell positive for cytoplasmic CD22 antigen", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "UMLS:C1513975", "l": "Neoplastic Glandular Cell with Enlarged Nucleus", "d": [], "t": []}, {"i": "NCIT:C37122", "l": "Neoplastic Glandular Cell with Enlarged Nucleus", "d": [], "t": []}], "preferred_name": "Neoplastic Glandular Cell with Enlarged Nucleus", "taxa": []}
{"type": "biolink:Cell", "ic": 71.83956976897835, "identifiers": [{"i": "CL:0000912", "l": "helper T cell", "d": ["A effector T cell that provides help in the form of secreted cytokines to other immune cells."], "t": []}, {"i": "UMLS:C0039215", "l": "CD4 Positive T Lymphocytes", "d": [], "t": []}, {"i": "NCIT:C12537", "l": "CD4-Positive T-Lymphocyte", "d": [], "t": []}, {"i": "MESH:D015496", "l": "CD4-Positive T-Lymphocytes", "d": [], "t": []}, {"i": "SNOMEDCT:115412003", "l": "", "d": [], "t": []}], "preferred_name": "helper T cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5148826", "l": "Reticulocytes.medium fluorescence", "d": [], "t": []}], "preferred_name": "Reticulocytes.medium fluorescence", "taxa": []}
{"type": "biolink:Cell", "ic": 70.15433324931317, "identifiers": [{"i": "UMLS:C1708917", "l": "Malignant Spindle-Shaped Smooth Muscle Cell", "d": [], "t": []}, {"i": "NCIT:C49126", "l": "Malignant Spindle-Shaped Smooth Muscle Cell", "d": [], "t": []}], "preferred_name": "Malignant Spindle-Shaped Smooth Muscle Cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5834401", "l": "Autologous CD3+ T cells genetically modified using a non-viral system to express a CD33 CAR, membrane bound Interleukin-15, and a truncated form of human HER1t (kill switch) on the cell surface", "d": [], "t": []}], "preferred_name": "Autologous CD3+ T cells genetically modified using a non-viral system to express a CD33 CAR, membrane bound Interleukin-15, and a truncated form of human HER1t (kill switch) on the cell surface", "taxa": []}
{"type": "biolink:Cell", "ic": 92.76600187037766, "identifiers": [{"i": "UMLS:C1514205", "l": "Polylobated T-Lymphocyte", "d": [], "t": []}, {"i": "NCIT:C39599", "l": "Polylobated T-Lymphocyte", "d": [], "t": []}], "preferred_name": "Polylobated T-Lymphocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 86.30756602822301, "identifiers": [{"i": "UMLS:C1510965", "l": "Atypical Squamous Cells", "d": [], "t": []}, {"i": "NCIT:C36913", "l": "Atypical Squamous Cell", "d": [], "t": []}], "preferred_name": "Atypical Squamous Cells", "taxa": []}
{"type": "biolink:Cell", "ic": 83.63771255585968, "identifiers": [{"i": "UMLS:C1708914", "l": "Malignant Spindle-Shaped to Round Cell", "d": [], "t": []}, {"i": "NCIT:C51147", "l": "Malignant Spindle-Shaped to Round Cell", "d": [], "t": []}], "preferred_name": "Malignant Spindle-Shaped to Round Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 66.66448812041634, "identifiers": [{"i": "CL:0000893", "l": "thymocyte", "d": ["An immature T cell located in the thymus."], "t": []}, {"i": "UMLS:C0814999", "l": "thymocyte", "d": [], "t": []}, {"i": "NCIT:C12994", "l": "Thymocyte", "d": ["A cell that develops in the thymus, seemingly from a stem cell of bone marrow and of fetal liver, and is the precursor of the thymus-derived lymphocyte (T lymphocyte) that effects cell-mediated (delayed type) sensitivity."], "t": []}, {"i": "MESH:D060168", "l": "Thymocytes", "d": [], "t": []}, {"i": "SNOMEDCT:39105001", "l": "", "d": [], "t": []}], "preferred_name": "thymocyte", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C6005371", "l": "Ruibosheng", "d": [], "t": []}], "preferred_name": "Ruibosheng", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5177460", "l": "Plasma cells with abnormal marker pattern | Bone marrow | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Plasma cells with abnormal marker pattern | Bone marrow | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "CL:2000002", "l": "decidual cell", "d": ["A specialized, enlarged, connective tissue cell of the decidua with enlarged nucleus, dense membrane‐bound secretory granules and cytoplasmic accumulation of glycogen and lipid droplets. These cells develop by the transformation of endometrial stromal cells during decidualization."], "t": []}, {"i": "UMLS:C1511740", "l": "Decidual cell", "d": [], "t": []}, {"i": "NCIT:C32429", "l": "Decidual Cell", "d": ["An endometrial fibroblast that differentiates during pregnancy in response to the implanting embryo by accumulating lipid and glycogen. It is polygonal, possesses a large, vesicular nucleus and is believed to secrete placental prolactin. The decidual cells form a tightly adherent, massive cellular matrix that first surrounds the implanting embryo and later occupies most of the endometrium."], "t": []}], "preferred_name": "decidual cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1657751", "l": "CD4+CD7+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:1373112004", "l": "", "d": [], "t": []}], "preferred_name": "CD4+CD7+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": 71.06400748151069, "identifiers": [{"i": "UMLS:C1514006", "l": "Neoplastic Centroblast", "d": [], "t": []}, {"i": "NCIT:C37014", "l": "Neoplastic Centroblast", "d": [], "t": []}], "preferred_name": "Neoplastic Centroblast", "taxa": []}
{"type": "biolink:Cell", "ic": 76.40371442623734, "identifiers": [{"i": "CL:0000825", "l": "pro-NK cell", "d": ["A lymphoid progenitor cell that is committed to the natural killer cell lineage, expressing CD122 (IL-15) receptor, but lacking many of the phenotypic characteristics of later stages of natural killer cell development such as expression of NK activating and inhibitory molecules. In human this cell has the phenotype CD34-positive, CD45RA-positive, CD10-positive, CD117-negative, and CD161 negative."], "t": []}], "preferred_name": "pro-NK cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1979672", "l": "CD4+CD7- cell", "d": [], "t": []}, {"i": "SNOMEDCT:1373186006", "l": "", "d": [], "t": []}], "preferred_name": "CD4+CD7- cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5170925", "l": "Leukocytes | Cervix | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Leukocytes | Cervix | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4263664", "l": "Lymphocyte T-cell & B-cell & Natural killer subsets", "d": [], "t": []}], "preferred_name": "Lymphocyte T-cell & B-cell & Natural killer subsets", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "CL:0002019", "l": "Ly-76 high reticulocyte", "d": ["A reticulocyte that is Ly76-high and is Kit-negative."], "t": []}], "preferred_name": "Ly-76 high reticulocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 90.871710685482, "identifiers": [{"i": "CL:1000448", "l": "epithelial cell of sweat gland", "d": ["An epithelial cell that is part of the sweat gland."], "t": []}, {"i": "UMLS:C1182778", "l": "Epithelial cell of sweat gland", "d": [], "t": []}], "preferred_name": "epithelial cell of sweat gland", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5216295", "l": "Neutrophils|NCnc|Pt|Plr fld", "d": [], "t": []}], "preferred_name": "Neutrophils|NCnc|Pt|Plr fld", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C6053201", "l": "Allogeneic Anti-TROP2-CAR-IL-15-transduced TGFBR2-knockout Cord Blood-derived Natural Killer Cells", "d": [], "t": []}, {"i": "NCIT:C220579", "l": "Allogeneic Anti-TROP2-CAR-IL-15-transduced TGFBR2-knockout Cord Blood-derived Natural Killer Cells", "d": ["A preparation of allogeneic, umbilical cord blood (CB)-derived natural killer cells (NKs) that have been engineered to express a chimeric antigen receptor (CAR) specific for the tumor-associated antigen (TAA) trophoblast cell surface protein 2 (trophoblast antigen 2; tumor-associated calcium signal transducer 2; TROP2; TROP-2; TACSTD2; GA733-1; M1S1) and expressing the cytokine interleukin-15 (IL-15) and in which the gene transforming growth factor-beta receptor II (TGFbRII; TGFBR2) is deleted, with potential immunostimulating and antineoplastic activities. Upon administration, the allogeneic anti-TROP2-CAR-IL-15-transduced TGFBR2-KO CB-derived NK cells target, bind to and induce selective cytotoxicity in TROP2-expressing tumor cells. TROP2 is a transmembrane protein overexpressed in various tumors. Its expression is associated with enhanced tumor aggressiveness, metastasis, drug resistance and increased tumor cell survival. IL-15 is a pro-survival cytokine that promotes the persistence of multiple lymphocyte lineages and potentiates the immune response against tumor cells. As TGF-beta activation and release leads to NK cell inactivation, deletion of the TGFBR2 gene increases the potency, persistence and efficacy of the NK cells and enhances anti-tumor activity."], "t": []}], "preferred_name": "Allogeneic Anti-TROP2-CAR-IL-15-transduced TGFBR2-knockout Cord Blood-derived Natural Killer Cells", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0002467", "l": "Gr1-high myeloid suppressor cell", "d": ["A myeloid suppressor cell that is Gr1-high and CD11c-negative."], "t": []}], "preferred_name": "Gr1-high myeloid suppressor cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C3496533", "l": "A13 dopamine cells", "d": [], "t": []}], "preferred_name": "A13 dopamine cells", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1277067", "l": "Entire corneal corpuscle", "d": [], "t": []}, {"i": "SNOMEDCT:368826000", "l": "", "d": [], "t": []}], "preferred_name": "Entire corneal corpuscle", "taxa": []}
{"type": "biolink:Cell", "ic": 69.87704306295657, "identifiers": [{"i": "UMLS:C4527420", "l": "T-cell Receptor-engineered T-cells", "d": [], "t": []}, {"i": "NCIT:C138180", "l": "T-cell Receptor-engineered T-cells", "d": ["T-lymphocytes that have been engineered to express a modified antigen-specific T-cell receptor (TCR). In cancer therapy, the TCR-engineered T-cell recognizes a tumor-specific protein fragment complexed with major histocompatibility complex (MHC) molecules on the surface of the tumor cells and kills the tumor cell."], "t": []}], "preferred_name": "T-cell Receptor-engineered T-cells", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4304384", "l": "hypothalamic gonadotropin-releasing hormone neuron (Mmus)", "d": ["A hypothalamic gonadotropin-releasing hormone neuron of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Gnrh1 (Mmus). It is glutamatergic. These cells are located in the Hypothalamus, Olfactory areas, Pallidum, brain , in or close to the regions: Lateral septal nucleus, rostral (rostroventral) part, Medial septal nucleus, Diagonal band nucleus . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:2564 HY Gnrh1 Glut_1.", "A hypothalamic gonadotropin-releasing hormone neuron of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Gnrh1 (Mmus). It is glutamatergic (inferred from expression of Gad1, Slc17a6, Gad2). These cells are located in the Hypothalamus, Olfactory areas, Pallidum, brain , in or close to the regions: Lateral septal nucleus, rostral (rostroventral) part, Medial septal nucleus, Diagonal band nucleus . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:2564 HY Gnrh1 Glut_1."], "t": []}], "preferred_name": "hypothalamic gonadotropin-releasing hormone neuron (Mmus)", "taxa": []}
{"type": "biolink:Cell", "ic": 80.61184433509295, "identifiers": [{"i": "CL:0000594", "l": "skeletal muscle satellite cell", "d": ["An elongated, spindle-shaped, cell that is located between the basal lamina and the plasmalemma of a muscle fiber. These cells are mostly quiescent, but upon activation they divide to produce cells that generate new muscle fibers."], "t": []}, {"i": "UMLS:C0599856", "l": "Muscle satellite cell", "d": [], "t": []}, {"i": "MESH:D032496", "l": "Satellite Cells, Skeletal Muscle", "d": [], "t": []}], "preferred_name": "skeletal muscle satellite cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5690102", "l": "Cells.CD4.Interferon gamma-expressing", "d": [], "t": []}], "preferred_name": "Cells.CD4.Interferon gamma-expressing", "taxa": []}
{"type": "biolink:Cell", "ic": 92.76600187037766, "identifiers": [{"i": "CL:1001006", "l": "kidney afferent arteriole cell", "d": ["An endothelial cell which is part of the afferent arteriole in the kidney. This cell is  responsible for maintaining renal blood flow and glomerular filtration rate."], "t": []}], "preferred_name": "kidney afferent arteriole cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5157458", "l": "CD3+CD8+ (T8 suppressor) cells | XXX | Cell markers", "d": [], "t": []}], "preferred_name": "CD3+CD8+ (T8 suppressor) cells | XXX | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C3831438", "l": "Autologous Cultured Acute Myeloid Leukemia-specific Cytotoxic T Lymphocytes", "d": [], "t": []}, {"i": "NCIT:C111996", "l": "Autologous Cultured Acute Myeloid Leukemia-specific Cytotoxic T Lymphocytes", "d": ["A preparation of cytotoxic, autologous acute myelogenous leukemia (AML)-reactive T lymphocytes (CTL), with potential immunomodulating and antineoplastic activities. The autologous cultured AML-specific CTLs are prepared using a specific AML-CTL culture method. Autologous peripheral blood lymphocytes are taken from an AML patient and the autologous AML blasts are treated with granulocyte macrophage colony-stimulating factor (GM-CSF) and interleukin 4 (IL-4), both of which promote ex vivo differentiation of AML blasts into dendritic cells (DCs). In the same culture, T cells are treated and activated by low-dose interleukin 2 (IL-2), and expanded using anti-CD3. This results in cultured AML-reactive CTLs which are administered back into the patient after autologous hematopoietic stem cell transplant (AHSCT). The autologous cultured AML-specific CTLs may eradicate residual AML cells."], "t": []}], "preferred_name": "Autologous Cultured Acute Myeloid Leukemia-specific Cytotoxic T Lymphocytes", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5171584", "l": "Lymphoblasts | Blood | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Lymphoblasts | Blood | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": 89.40238429118027, "identifiers": [{"i": "CL:4023065", "l": "meis2 expressing cortical GABAergic cell", "d": ["A GABAergic cell located in the cerebral cortex that expresses meis2."], "t": []}], "preferred_name": "meis2 expressing cortical GABAergic cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1257742", "l": "BALB 3T3 clone A31", "d": [], "t": []}], "preferred_name": "BALB 3T3 clone A31", "taxa": []}
{"type": "biolink:Cell", "ic": 90.871710685482, "identifiers": [{"i": "UMLS:C0333836", "l": "Sea-blue histiocyte", "d": [], "t": []}, {"i": "NCIT:C36733", "l": "Sea-Blue Histiocyte", "d": [], "t": []}, {"i": "SNOMEDCT:39474009", "l": "", "d": [], "t": []}], "preferred_name": "Sea-blue histiocyte", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1442179", "l": "Amniotic Fluid cells", "d": [], "t": []}], "preferred_name": "Amniotic Fluid cells", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5182508", "l": "Synovial lining cells | Synovial fluid | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Synovial lining cells | Synovial fluid | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4072041", "l": "L6 intratelencephalic projecting glutamatergic neuron (Homo sapiens)", "d": ["A transcriptomically distinct intratelencephalic-projecting glutamatergic neuron with a soma found in L6 of the primary motor cortex. These cells are short untufted pyramidal cells, which could be stellate or inverted.  The standard transcriptomic reference data for this cell type can be found on the CellxGene census under the collection: 'Transcriptomic cytoarchitecture reveals principles of human neocortex organization', dataset: 'Supercluster: IT-projecting excitatory neurons', Author Categories: 'CrossArea_subclass', L6 IT."], "t": []}], "preferred_name": "L6 intratelencephalic projecting glutamatergic neuron (Homo sapiens)", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5157517", "l": "CD3-CD16+ cells | Bone marrow | Cell markers", "d": [], "t": []}], "preferred_name": "CD3-CD16+ cells | Bone marrow | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": 67.18460065295824, "identifiers": [{"i": "UMLS:C1181052", "l": "Thyroid Gland Follicular Cell", "d": [], "t": []}, {"i": "NCIT:C33783", "l": "Thyroid Gland Follicular Cell", "d": ["An epithelial cell lining the thyroid follicles."], "t": []}, {"i": "MESH:D000072637", "l": "Thyroid Epithelial Cells", "d": [], "t": []}], "preferred_name": "Thyroid Gland Follicular Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:1001109", "l": "kidney loop of Henle cortical thick ascending limb epithelial cell", "d": ["An epithelial cell that is part of some loop of Henle thick ascending limb segment located in the renal cortex."], "t": []}], "preferred_name": "kidney loop of Henle cortical thick ascending limb epithelial cell", "taxa": []}
{"type": "biolink:Cell", "ic": 78.80476858236055, "identifiers": [{"i": "CL:0000059", "l": "ameloblast", "d": ["Skeletogenic cell that produces enamel, overlies the odontogenic papilla, and arises from the differentiation of a preameloblast cell."], "t": []}, {"i": "UMLS:C0002449", "l": "Ameloblasts", "d": [], "t": []}, {"i": "NCIT:C12579", "l": "Ameloblast", "d": ["A columnar epithelial cell located in the inner layer of the enamel organ of a developing tooth that plays a role in calcium transport and the synthesis and resorption of enamel matrix proteins."], "t": []}, {"i": "MESH:D000565", "l": "Ameloblasts", "d": [], "t": []}], "preferred_name": "ameloblast", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5853577", "l": "APR-2020", "d": [], "t": []}], "preferred_name": "APR-2020", "taxa": []}
{"type": "biolink:Cell", "ic": 72.615132056446, "identifiers": [{"i": "UMLS:C1708876", "l": "Malignant Fibroblast", "d": [], "t": []}, {"i": "NCIT:C49028", "l": "Malignant Fibroblast", "d": [], "t": []}], "preferred_name": "Malignant Fibroblast", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "CL:0002540", "l": "mesenchymal stem cell of the bone marrow", "d": ["A mesenchymal stem cell that is part of the bone marrow."], "t": []}], "preferred_name": "mesenchymal stem cell of the bone marrow", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5157670", "l": "CD8+CD45RA+ cells | Blood | Cell markers", "d": [], "t": []}], "preferred_name": "CD8+CD45RA+ cells | Blood | Cell markers", "taxa": []}
{"type": "biolink:Cell", "ic": 84.21065366064373, "identifiers": [{"i": "CL:0002048", "l": "late pro-B cell", "d": ["A pre-B cell precursor is CD19-low, CD22-positive , CD34-positive, CD38-positive."], "t": []}], "preferred_name": "late pro-B cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4310127", "l": "striatal VIP GABAergic interneuron (Primate)", "d": ["A VIP GABAergic interneuron of the Primates brain. These cells are located in the striatum . Reference transcriptomic data for this type can be found in the dataset/taxonomy - HMBA Basal Ganglia Consensus Taxonomy in cell set Group:VIP GABA."], "t": []}], "preferred_name": "striatal VIP GABAergic interneuron (Primate)", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4684874", "l": "P-BCMA-101", "d": [], "t": []}], "preferred_name": "P-BCMA-101", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5551176", "l": "Tumor cells", "d": [], "t": []}, {"i": "SNOMEDCT:252987004", "l": "", "d": [], "t": []}], "preferred_name": "Tumor cells", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "UMLS:C1523993", "l": "Mouse Macrophage", "d": [], "t": []}, {"i": "NCIT:C22587", "l": "Mouse Macrophage", "d": [], "t": []}], "preferred_name": "Mouse Macrophage", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C4086005", "l": "Autologous Cytotoxic T-lymphocytes Induced with MUC1 Gene-transfected Dendritic Cells", "d": [], "t": []}, {"i": "NCIT:C124997", "l": "Autologous Cytotoxic T-lymphocytes Induced with MUC1 Gene-transfected Dendritic Cells", "d": ["A preparation of autologous cytotoxic T-lymphocytes (CTL), specifically reactive to the tumor-associated antigen (TAA) mucin-1 (MUC1), with potential antineoplastic activity. Peripheral blood mononuclear cells (PBMCs) are collected from the patient with MUC1-positive tumors and are exposed ex vivo to dendritic cells (DCs) transfected with a replication-deficient adenovirus encoding MUC1 to generate MUC1-specific CTLs, which are subsequently expanded in vitro. Upon re-infusion of autologous CTLs induced with MUC1 gene-transfected DCs to the patient, the CTLs target and lyse the MUC1-expressing tumor cells. This inhibits tumor cell proliferation. MUC1 is expressed by a variety of tumor cell types."], "t": []}], "preferred_name": "Autologous Cytotoxic T-lymphocytes Induced with MUC1 Gene-transfected Dendritic Cells", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0019021", "l": "endothelial cell of periportal hepatic sinusoid", "d": ["An endothelial cell found in the periportal region hepatic sinusoid, near the portal triad. The fenestrae of these cells are larger but fewer in number compared with those of endothelial cells near the centrilobular region of the hepatic sinusoid."], "t": []}], "preferred_name": "endothelial cell of periportal hepatic sinusoid", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5555029", "l": "Allogeneic CRISPR-edited Anti-CD19 CAR T Cells PBLTT52CAR19", "d": [], "t": []}, {"i": "NCIT:C178434", "l": "Allogeneic CRISPR-edited Anti-CD19 CAR T Cells PBLTT52CAR19", "d": ["A preparation of allogeneic T-lymphocytes transduced with a lentiviral vector encoding a chimeric antigen receptor (CAR) specific for the tumor-associated antigen (TAA) CD19, with genetic modification of CD52 and T-cell receptor alpha constant (TRAC) loci via clustered regularly interspaced short palindromic repeats (CRISPR), with potential immunostimulating and antineoplastic activities. Upon administration, the allogeneic CRISPR-edited anti-CD19 CAR T cells PBLTT52CAR19 recognize and bind to CD19-overexpressing tumor cells. This may result in a specific cytotoxic T-lymphocyte (CTL)-mediated killing of CD19-positive tumor cells. CD19 antigen is a B-cell specific cell surface antigen expressed in all B-cell lineage malignancies. The editing of the CD52 gene may make the modified donor T-cells resistant to the anti-CD52 monoclonal antibody alemtuzumab, which is used during lymphodepletion. The editing of the TRAC may eliminate TCR expression, which may abrogate the potential induction of graft-versus-host disease (GvHD) by the donor T-cells, and may also result in uniform CAR expression and enhanced T-cell potency."], "t": []}], "preferred_name": "Allogeneic CRISPR-edited Anti-CD19 CAR T Cells PBLTT52CAR19", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:0000249", "l": "hatching gland cell", "d": [], "t": []}], "preferred_name": "hatching gland cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C2362084", "l": "Washed packed erythrocytes", "d": [], "t": []}], "preferred_name": "Washed packed erythrocytes", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C2950040", "l": "Type D cell of ileum", "d": [], "t": []}], "preferred_name": "Type D cell of ileum", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:1001210", "l": "outer medulla vasa recta ascending limb cell", "d": ["Any vasa recta ascending limb cell that is part of some outer medulla ascending vasa recta."], "t": []}], "preferred_name": "outer medulla vasa recta ascending limb cell", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "CL:0000994", "l": "immature CD11c-negative plasmacytoid dendritic cell", "d": ["Immature CD11c-negative plasmacytoid dendritic cell is a CD11c-negative plasmacytoid dendritic cell is CD80-negative, CD86-low and MHCII-low."], "t": []}], "preferred_name": "immature CD11c-negative plasmacytoid dendritic cell", "taxa": []}
{"type": "biolink:Cell", "ic": 86.30756602822301, "identifiers": [{"i": "UMLS:C0333862", "l": "Giant megakaryocyte", "d": [], "t": []}, {"i": "NCIT:C37045", "l": "Giant Megakaryocyte", "d": [], "t": []}, {"i": "SNOMEDCT:60191001", "l": "", "d": [], "t": []}], "preferred_name": "Giant megakaryocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 62.39872902467222, "identifiers": [{"i": "CL:0000019", "l": "sperm", "d": ["A mature male germ cell that develops from a spermatid."], "t": []}], "preferred_name": "sperm", "taxa": []}
{"type": "biolink:Cell", "ic": 90.871710685482, "identifiers": [{"i": "CL:0000131", "l": "gut endothelial cell", "d": ["An endothelial cell that lines the blood and lymphatic vessels of the digestive tract. This cell forms the gut–vascular barrier (GVB) through tight junctions and crosstalk with pericytes and enteric glial cells, regulating the passage of nutrients and immune cells while restricting microbial translocation into the bloodstream."], "t": []}], "preferred_name": "gut endothelial cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5886244", "l": "Cells.chromosome region 1p32", "d": [], "t": []}], "preferred_name": "Cells.chromosome region 1p32", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4518149", "l": "Population of all spermatozoa with broken tail in portion of fluid", "d": [], "t": []}, {"i": "SNOMEDCT:725253001", "l": "", "d": [], "t": []}], "preferred_name": "Population of all spermatozoa with broken tail in portion of fluid", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "CL:4033109", "l": "middle cervical ganglion TH neuron", "d": ["A sympathetic neuron that has the soma located in the middle cervical ganglion and expresses the marker tyrosine hydroxylase (TH)."], "t": []}], "preferred_name": "middle cervical ganglion TH neuron", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C0882865", "l": "CD4+HLA-DR+ cell", "d": [], "t": []}, {"i": "SNOMEDCT:1373115002", "l": "", "d": [], "t": []}], "preferred_name": "CD4+HLA-DR+ cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C4764336", "l": "OmnImmune", "d": [], "t": []}], "preferred_name": "OmnImmune", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C5669194", "l": "Anti-BCMA CAR-NK Cells", "d": [], "t": []}, {"i": "NCIT:C184309", "l": "Anti-BCMA CAR-NK Cells", "d": ["A preparation of umbilical cord blood (CB)-derived natural killer cells (NKs) expressing a chimeric antigen receptor (CAR) specific for the tumor-associated antigen (TAA) B-cell maturation antigen (BCMA; tumor necrosis factor receptor superfamily member 17; TNFRSF17), with potential immunomodulating and antineoplastic activities. Upon transfusion, the anti-BCMA CAR-NK cells recognize, bind to and induce selective cytotoxicity in BCMA-expressing tumor cells. BCMA, a receptor for both a proliferation-inducing ligand (APRIL) and B-cell activating factor (BAFF), is a member of the tumor necrosis factor receptor superfamily (TNFRSF). BCMA is found on the surfaces of plasma cells, is overexpressed on malignant plasma cells and plays a key role in plasma cell proliferation and survival."], "t": []}], "preferred_name": "Anti-BCMA CAR-NK Cells", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C1254546", "l": "Anisocyte (cell)", "d": [], "t": []}], "preferred_name": "Anisocyte (cell)", "taxa": []}
{"type": "biolink:Cell", "ic": 92.76600187037766, "identifiers": [{"i": "CL:2000010", "l": "dermis blood vessel endothelial cell", "d": ["Any blood vessel endothelial cell that is part of a dermis."], "t": []}], "preferred_name": "dermis blood vessel endothelial cell", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5180942", "l": "Siderocytes per HPF | Blood | Hematology and Cell counts", "d": [], "t": []}], "preferred_name": "Siderocytes per HPF | Blood | Hematology and Cell counts", "taxa": []}
{"type": "biolink:Cell", "ic": 89.40238429118027, "identifiers": [{"i": "CL:0002346", "l": "Dx5-negative, NK1.1-positive immature natural killer cell, mouse", "d": ["An immature natural killer cell that is NK1.1-positive and DX-5 negative."], "t": []}], "preferred_name": "Dx5-negative, NK1.1-positive immature natural killer cell, mouse", "taxa": []}
{"type": "biolink:Cell", "ic": 79.07356789860069, "identifiers": [{"i": "CL:0000639", "l": "basophil cell of pars distalis of adenohypophysis", "d": ["A basophilic chromophil cell that of the anterior pituitary gland."], "t": []}, {"i": "UMLS:C0229537", "l": "Pituitary beta cell", "d": [], "t": []}, {"i": "SNOMEDCT:37514005", "l": "", "d": [], "t": []}], "preferred_name": "basophil cell of pars distalis of adenohypophysis", "taxa": []}
{"type": "biolink:Cell", "ic": 52.70658968628814, "identifiers": [{"i": "UMLS:C1514048", "l": "Neoplastic Neuroepithelial Cell", "d": [], "t": []}, {"i": "NCIT:C37125", "l": "Neoplastic Neuroepithelial Cell", "d": [], "t": []}], "preferred_name": "Neoplastic Neuroepithelial Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C6049806", "l": "Soficabtagene Geleucel", "d": [], "t": []}, {"i": "NCIT:C215281", "l": "Soficabtagene Geleucel", "d": [], "t": []}], "preferred_name": "Soficabtagene Geleucel", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C5216267", "l": "Metamyelocytes|NCnc|Pt|Bld", "d": [], "t": []}], "preferred_name": "Metamyelocytes|NCnc|Pt|Bld", "taxa": []}
{"type": "biolink:Cell", "ic": 100.0, "identifiers": [{"i": "UMLS:C4053969", "l": "Suppressive Monocyte", "d": [], "t": []}, {"i": "NCIT:C122732", "l": "Suppressive Monocyte", "d": ["A population of monocytes that express CD14 and low or non-detectable levels of HLA-DR. The cells are able to suppress cellular immunity by inhibiting both T-cell proliferation and dendritic cell maturation."], "t": []}], "preferred_name": "Suppressive Monocyte", "taxa": []}
{"type": "biolink:Cell", "ic": 90.871710685482, "identifiers": [{"i": "CL:0002539", "l": "aortic smooth muscle cell", "d": ["A smooth muscle cell of the aorta."], "t": []}], "preferred_name": "aortic smooth muscle cell", "taxa": []}
{"type": "biolink:Cell", "ic": 64.24955689095262, "identifiers": [{"i": "CL:4023017", "l": "sst GABAergic cortical interneuron", "d": ["A transcriptomically distinct GABAergic neuron located in the cerebral cortex that expresses somatostatin (sst) and derived from the MGE.", "A transcriptomically distinct GABAergic neuron located in the cerebral cortex that expresses somatostatin (sst). The standard transcriptomic reference data for this cell type can be found on the CellxGene census under the collection: 'Transcriptomic cytoarchitecture reveals principles of human neocortex organization', dataset: 'Supercluster: MGE-derived interneurons', Author Categories: 'CrossArea_subclass', cluster Sst."], "t": []}], "preferred_name": "sst GABAergic cortical interneuron", "taxa": []}
{"type": "biolink:Cell", "ic": null, "identifiers": [{"i": "UMLS:C3496353", "l": "C1 adrenaline cells", "d": [], "t": []}], "preferred_name": "C1 adrenaline cells", "taxa": []}
{"type": "biolink:Cell", "ic": 70.90339783960249, "identifiers": [{"i": "UMLS:C1513958", "l": "Neoplastic Ependymal Cell", "d": [], "t": []}, {"i": "NCIT:C37143", "l": "Neoplastic Ependymal Cell", "d": [], "t": []}], "preferred_name": "Neoplastic Ependymal Cell", "taxa": []}
{"type": "biolink:Cell", "ic": 95.43585534274101, "identifiers": [{"i": "UMLS:C1513955", "l": "Neoplastic Endocrine Null Cell", "d": [], "t": []}, {"i": "NCIT:C36923", "l": "Neoplastic Endocrine Null Cell", "d": [], "t": []}], "preferred_name": "Neoplastic Endocrine Null Cell", "taxa": []}