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At least in mammals, IRE1 can also signal through additional intracellular pathways including JNK and NF-kappaB."], "t": []}], "preferred_name": "IRE1-mediated unfolded protein response", "taxa": []} {"type": "biolink:Pathway", "ic": null, "identifiers": [{"i": "SMPDB:SMP0057277", "l": "Cardiolipin Biosynthesis CL(i-13:0/i-13:0/a-17:0/i-24:0),Disease", "d": [], "t": []}], "preferred_name": "Cardiolipin Biosynthesis CL(i-13:0/i-13:0/a-17:0/i-24:0),Disease", "taxa": []} {"type": "biolink:Pathway", "ic": null, "identifiers": [{"i": "SMPDB:SMP0061213", "l": "Cardiolipin Biosynthesis CL(i-14:0/a-15:0/a-17:0/a-17:0),Disease", "d": [], "t": []}], "preferred_name": "Cardiolipin Biosynthesis CL(i-14:0/a-15:0/a-17:0/a-17:0),Disease", "taxa": []} {"type": "biolink:Pathway", "ic": null, "identifiers": [{"i": "SMPDB:SMP0038529", "l": "De Novo Triacylglycerol Biosynthesis TG(a-21:0/i-16:0/i-21:0),Metabolic", "d": [], "t": []}], "preferred_name": "De Novo Triacylglycerol Biosynthesis TG(a-21:0/i-16:0/i-21:0),Metabolic", "taxa": []} {"type": "biolink:Pathway", "ic": null, "identifiers": [{"i": "SMPDB:SMP0053407", "l": "Cardiolipin Biosynthesis CL(i-12:0/i-19:0/a-21:0/i-17:0),Disease", "d": [], "t": []}], "preferred_name": "Cardiolipin Biosynthesis CL(i-12:0/i-19:0/a-21:0/i-17:0),Disease", "taxa": []} {"type": "biolink:Pathway", "ic": null, "identifiers": [{"i": "REACT:R-BTA-6787639", "l": "GDP-fucose biosynthesis (Bos taurus)", "d": [], "t": []}], "preferred_name": "GDP-fucose biosynthesis (Bos taurus)", "taxa": []} {"type": "biolink:Pathway", "ic": null, "identifiers": [{"i": "SMPDB:SMP0050721", "l": "Cardiolipin Biosynthesis CL(i-12:0/a-21:0/i-24:0/a-15:0),Disease", "d": [], "t": []}], "preferred_name": "Cardiolipin Biosynthesis CL(i-12:0/a-21:0/i-24:0/a-15:0),Disease", "taxa": []} {"type": "biolink:Pathway", "ic": null, "identifiers": [{"i": "SMPDB:SMP0054553", "l": "Cardiolipin Biosynthesis CL(i-12:0/i-22:0/i-20:0/i-15:0),Disease", "d": [], "t": []}], "preferred_name": "Cardiolipin Biosynthesis CL(i-12:0/i-22:0/i-20:0/i-15:0),Disease", "taxa": []} {"type": "biolink:Pathway", "ic": null, "identifiers": [{"i": "SMPDB:SMP0042711", "l": "De Novo Triacylglycerol Biosynthesis TG(i-24:0/20:0/10:0),Metabolic", "d": [], "t": []}], "preferred_name": "De Novo Triacylglycerol Biosynthesis TG(i-24:0/20:0/10:0),Metabolic", "taxa": []} {"type": "biolink:Pathway", "ic": null, "identifiers": [{"i": "REACT:R-DME-69239", "l": "Synthesis of DNA (Drosophila melanogaster)", "d": [], "t": []}], "preferred_name": "Synthesis of DNA (Drosophila melanogaster)", "taxa": []} {"type": "biolink:Pathway", "ic": null, "identifiers": [{"i": "SMPDB:SMP0039708", "l": "De Novo Triacylglycerol Biosynthesis TG(i-19:0/a-25:0/16:0),Metabolic", "d": [], "t": []}], "preferred_name": "De Novo Triacylglycerol Biosynthesis TG(i-19:0/a-25:0/16:0),Metabolic", "taxa": []} {"type": "biolink:Pathway", "ic": null, "identifiers": [{"i": "REACT:R-DME-1307965", "l": "betaKlotho-mediated ligand binding (Drosophila melanogaster)", "d": [], "t": []}], "preferred_name": "betaKlotho-mediated ligand binding (Drosophila melanogaster)", "taxa": []} {"type": "biolink:Pathway", "ic": null, "identifiers": [{"i": "REACT:R-DME-69200", "l": "Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes (Drosophila melanogaster)", "d": [], "t": []}], "preferred_name": "Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes (Drosophila melanogaster)", "taxa": []} {"type": "biolink:Pathway", "ic": null, "identifiers": [{"i": "REACT:R-RNO-597592", "l": "Post-translational protein modification (Rattus norvegicus)", "d": [], "t": []}], "preferred_name": "Post-translational protein modification (Rattus norvegicus)", "taxa": []} {"type": "biolink:Pathway", "ic": null, "identifiers": [{"i": "SMPDB:SMP0060563", "l": "Cardiolipin Biosynthesis CL(i-13:0/i-24:0/a-17:0/i-13:0),Disease", "d": [], "t": []}], "preferred_name": "Cardiolipin Biosynthesis CL(i-13:0/i-24:0/a-17:0/i-13:0),Disease", "taxa": []} {"type": "biolink:Pathway", "ic": null, "identifiers": [{"i": "REACT:R-CEL-181431", "l": "Acetylcholine binding and downstream events (Caenorhabditis elegans)", "d": [], "t": []}], "preferred_name": "Acetylcholine binding and downstream events (Caenorhabditis elegans)", "taxa": []} {"type": "biolink:Pathway", "ic": null, "identifiers": [{"i": "SMPDB:SMP0030374", "l": "Phosphatidylethanolamine Biosynthesis PE(11M3/13M5),Metabolic", "d": [], "t": []}], "preferred_name": "Phosphatidylethanolamine Biosynthesis PE(11M3/13M5),Metabolic", "taxa": []} {"type": "biolink:Pathway", "ic": null, "identifiers": [{"i": "SMPDB:SMP0051755", "l": "Cardiolipin Biosynthesis CL(i-12:0/i-14:0/a-15:0/i-16:0),Disease", "d": [], "t": []}], "preferred_name": "Cardiolipin Biosynthesis CL(i-12:0/i-14:0/a-15:0/i-16:0),Disease", "taxa": []} {"type": "biolink:Pathway", "ic": null, "identifiers": [{"i": "REACT:R-BTA-434316", "l": "Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion (Bos taurus)", "d": [], "t": []}], "preferred_name": "Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion (Bos taurus)", "taxa": []} {"type": "biolink:Pathway", "ic": null, "identifiers": [{"i": "REACT:R-BTA-177128", "l": "Conjugation of salicylate with glycine (Bos taurus)", "d": [], "t": []}], "preferred_name": "Conjugation of salicylate with glycine (Bos taurus)", "taxa": []} {"type": "biolink:Pathway", "ic": null, "identifiers": [{"i": "REACT:R-BTA-75896", "l": "Plasmalogen biosynthesis (Bos taurus)", "d": [], "t": []}], "preferred_name": "Plasmalogen biosynthesis (Bos taurus)", "taxa": []} {"type": "biolink:Pathway", "ic": null, "identifiers": [{"i": "REACT:R-DDI-166208", "l": "mTORC1-mediated signalling (Dictyostelium discoideum)", "d": [], "t": []}], "preferred_name": "mTORC1-mediated signalling (Dictyostelium discoideum)", "taxa": []} {"type": "biolink:Pathway", "ic": null, "identifiers": [{"i": "REACT:R-SCE-2029485", "l": "Role of phospholipids in phagocytosis (Saccharomyces cerevisiae)", "d": [], "t": []}], "preferred_name": "Role of phospholipids in phagocytosis (Saccharomyces cerevisiae)", "taxa": []} {"type": "biolink:Pathway", "ic": null, "identifiers": [{"i": "SMPDB:SMP0044341", "l": "Cardiolipin Biosynthesis CL(a-13:0/a-17:0/a-15:0/i-22:0),Disease", "d": [], "t": []}], "preferred_name": "Cardiolipin Biosynthesis CL(a-13:0/a-17:0/a-15:0/i-22:0),Disease", "taxa": []} {"type": "biolink:Pathway", "ic": null, "identifiers": [{"i": "SMPDB:SMP0047753", "l": "Cardiolipin Biosynthesis CL(a-13:0/i-19:0/i-19:0/i-13:0),Disease", "d": [], "t": []}], "preferred_name": "Cardiolipin Biosynthesis CL(a-13:0/i-19:0/i-19:0/i-13:0),Disease", "taxa": []} {"type": "biolink:Pathway", "ic": null, "identifiers": [{"i": "SMPDB:SMP0054084", "l": "Cardiolipin Biosynthesis CL(i-12:0/i-21:0/i-12:0/a-25:0),Disease", "d": [], "t": []}], "preferred_name": "Cardiolipin Biosynthesis CL(i-12:0/i-21:0/i-12:0/a-25:0),Disease", "taxa": []} {"type": "biolink:Pathway", "ic": null, "identifiers": [{"i": "SMPDB:SMP0059211", "l": "Promethazine H1-Antihistamine Action,Drug Action", "d": [], "t": []}], "preferred_name": "Promethazine H1-Antihistamine Action,Drug Action", "taxa": []} {"type": "biolink:Pathway", "ic": 88.20185721311867, "identifiers": [{"i": "GO:0009740", "l": "gibberellic acid mediated signaling pathway", "d": ["The series of molecular signals mediated by the detection of gibberellic acid."], "t": []}], "preferred_name": "gibberellic acid mediated signaling pathway", "taxa": []} {"type": "biolink:Pathway", "ic": null, "identifiers": [{"i": "REACT:R-DDI-947581", "l": "Molybdenum cofactor biosynthesis (Dictyostelium discoideum)", "d": [], "t": []}], "preferred_name": "Molybdenum cofactor biosynthesis (Dictyostelium discoideum)", "taxa": []} {"type": "biolink:Pathway", "ic": null, "identifiers": [{"i": "SMPDB:SMP0034094", "l": "De Novo Triacylglycerol 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"preferred_name": "TP53 Regulates Transcription of Genes Involved in Cytochrome C Release (Plasmodium falciparum)", "taxa": []} {"type": "biolink:Pathway", "ic": null, "identifiers": [{"i": "SMPDB:SMP0039651", "l": "De Novo Triacylglycerol Biosynthesis TG(i-19:0/22:0/17:0),Metabolic", "d": [], "t": []}], "preferred_name": "De Novo Triacylglycerol Biosynthesis TG(i-19:0/22:0/17:0),Metabolic", "taxa": []} {"type": "biolink:Pathway", "ic": null, "identifiers": [{"i": "SMPDB:SMP0056945", "l": "Cardiolipin Biosynthesis CL(i-13:0/i-12:0/a-17:0/i-12:0),Disease", "d": [], "t": []}], "preferred_name": "Cardiolipin Biosynthesis CL(i-13:0/i-12:0/a-17:0/i-12:0),Disease", "taxa": []} {"type": "biolink:Pathway", "ic": null, "identifiers": [{"i": "SMPDB:SMP0035501", "l": "De Novo Triacylglycerol Biosynthesis TG(21:0/8:0/a-13:0),Metabolic", "d": [], "t": []}], "preferred_name": "De Novo Triacylglycerol Biosynthesis TG(21:0/8:0/a-13:0),Metabolic", "taxa": []} {"type": "biolink:Pathway", "ic": null, "identifiers": [{"i": "REACT:R-HSA-75158", "l": "TRAIL signaling (Homo sapiens)", "d": [], "t": []}], "preferred_name": "TRAIL signaling (Homo sapiens)", "taxa": []} {"type": "biolink:Pathway", "ic": null, "identifiers": [{"i": "REACT:R-DME-110526", "l": "Insulin receptor mediated signaling (Drosophila melanogaster)", "d": [], "t": []}], "preferred_name": "Insulin receptor mediated signaling (Drosophila melanogaster)", "taxa": []} {"type": "biolink:Pathway", "ic": null, "identifiers": [{"i": "SMPDB:SMP0050887", "l": "Cardiolipin Biosynthesis CL(i-12:0/a-25:0/i-14:0/i-12:0),Disease", "d": [], "t": []}], "preferred_name": "Cardiolipin Biosynthesis CL(i-12:0/a-25:0/i-14:0/i-12:0),Disease", "taxa": []} {"type": "biolink:Pathway", "ic": null, "identifiers": [{"i": "SMPDB:SMP0015229", "l": "Phosphatidylethanolamine Biosynthesis PE(18:1(11Z)/14:0),Metabolic", "d": [], "t": []}], "preferred_name": "Phosphatidylethanolamine Biosynthesis PE(18:1(11Z)/14:0),Metabolic", "taxa": []} {"type": 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{"type": "biolink:Pathway", "ic": null, "identifiers": [{"i": "SMPDB:SMP0053164", "l": "Cardiolipin Biosynthesis CL(i-12:0/i-18:0/i-15:0/a-13:0),Disease", "d": [], "t": []}], "preferred_name": "Cardiolipin Biosynthesis CL(i-12:0/i-18:0/i-15:0/a-13:0),Disease", "taxa": []} {"type": "biolink:Pathway", "ic": null, "identifiers": [{"i": "SMPDB:SMP0043087", "l": "De Novo Triacylglycerol Biosynthesis TG(i-24:0/i-15:0/i-21:0),Metabolic", "d": [], "t": []}], "preferred_name": "De Novo Triacylglycerol Biosynthesis TG(i-24:0/i-15:0/i-21:0),Metabolic", "taxa": []} {"type": "biolink:Pathway", "ic": null, "identifiers": [{"i": "REACT:R-SPO-6811558", "l": "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Schizosaccharomyces pombe)", "d": [], "t": []}], "preferred_name": "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Schizosaccharomyces pombe)", "taxa": []} {"type": "biolink:Pathway", "ic": null, "identifiers": [{"i": "SMPDB:SMP0043268", "l": "De Novo Triacylglycerol Biosynthesis 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"Cardiolipin Biosynthesis CL(a-13:0/a-21:0/i-21:0/i-24:0),Disease", "taxa": []} {"type": "biolink:Pathway", "ic": null, "identifiers": [{"i": "SMPDB:SMP0060823", "l": "Cardiolipin Biosynthesis CL(i-13:0/i-24:0/i-24:0/i-17:0),Disease", "d": [], "t": []}], "preferred_name": "Cardiolipin Biosynthesis CL(i-13:0/i-24:0/i-24:0/i-17:0),Disease", "taxa": []} {"type": "biolink:Pathway", "ic": null, "identifiers": [{"i": "REACT:R-XTR-983705", "l": "Signaling by the B Cell Receptor (BCR) (Xenopus tropicalis)", "d": [], "t": []}], "preferred_name": "Signaling by the B Cell Receptor (BCR) (Xenopus tropicalis)", "taxa": []} {"type": "biolink:Pathway", "ic": null, "identifiers": [{"i": "REACT:R-SPO-426117", "l": "Cation-coupled Chloride cotransporters (Schizosaccharomyces pombe)", "d": [], "t": []}], "preferred_name": "Cation-coupled Chloride cotransporters (Schizosaccharomyces pombe)", "taxa": []} {"type": "biolink:Pathway", "ic": null, "identifiers": [{"i": "SMPDB:SMP0030348", "l": "Phosphatidylethanolamine Biosynthesis PE(13D5/9M5),Metabolic", "d": [], "t": []}], "preferred_name": "Phosphatidylethanolamine Biosynthesis PE(13D5/9M5),Metabolic", "taxa": []} {"type": "biolink:Pathway", "ic": null, "identifiers": [{"i": "SMPDB:SMP0038061", "l": "De Novo Triacylglycerol Biosynthesis TG(a-21:0/17:0/i-17:0),Metabolic", "d": [], "t": []}], "preferred_name": "De Novo Triacylglycerol Biosynthesis TG(a-21:0/17:0/i-17:0),Metabolic", "taxa": []} {"type": "biolink:Pathway", "ic": null, "identifiers": [{"i": "SMPDB:SMP0057655", "l": "Cardiolipin Biosynthesis CL(i-13:0/i-14:0/i-12:0/i-14:0),Disease", "d": [], "t": []}], "preferred_name": "Cardiolipin Biosynthesis CL(i-13:0/i-14:0/i-12:0/i-14:0),Disease", "taxa": []} {"type": "biolink:Pathway", "ic": null, "identifiers": [{"i": "SMPDB:SMP0052127", "l": "Cardiolipin Biosynthesis CL(i-12:0/i-15:0/a-25:0/a-25:0),Disease", "d": [], "t": []}], "preferred_name": "Cardiolipin Biosynthesis CL(i-12:0/i-15:0/a-25:0/a-25:0),Disease", "taxa": []} {"type": "biolink:Pathway", "ic": null, "identifiers": [{"i": "REACT:R-BTA-73621", "l": "Pyrimidine catabolism (Bos taurus)", "d": [], "t": []}], "preferred_name": "Pyrimidine catabolism (Bos taurus)", "taxa": []} {"type": "biolink:Pathway", "ic": null, "identifiers": [{"i": "SMPDB:SMP0063284", "l": "Cardiolipin Biosynthesis CL(i-14:0/i-17:0/a-13:0/a-15:0),Disease", "d": [], "t": []}], "preferred_name": "Cardiolipin Biosynthesis CL(i-14:0/i-17:0/a-13:0/a-15:0),Disease", "taxa": []} {"type": "biolink:Pathway", "ic": null, "identifiers": [{"i": "SMPDB:SMP0038245", "l": "De Novo Triacylglycerol Biosynthesis TG(a-21:0/a-13:0/14:0),Metabolic", "d": [], "t": []}], "preferred_name": "De Novo Triacylglycerol Biosynthesis TG(a-21:0/a-13:0/14:0),Metabolic", "taxa": []} {"type": "biolink:Pathway", "ic": null, "identifiers": [{"i": "REACT:R-DDI-162710", "l": "Synthesis of glycosylphosphatidylinositol (GPI) (Dictyostelium discoideum)", "d": [], "t": []}], "preferred_name": "Synthesis of 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