ERG1_CANAL Squalene epoxidase ERG1 (sprot)


CP51_CANAL Lanosterol 14-alpha demethylase (sprot)


ACM1_MOUSE Muscarinic acetylcholine receptor M1 (sprot)


ACHA_TETCF Acetylcholine receptor subunit alpha (sprot)


DHI1_MOUSE 11-beta-hydroxysteroid dehydrogenase 1 (sprot)


DHI2_MOUSE 11-beta-hydroxysteroid dehydrogenase type 2 (sprot)


PCP_HUMAN Lysosomal Pro-X carboxypeptidase (sprot)


V1AR_HUMAN Vasopressin V1a receptor (sprot)


V2R_HUMAN Vasopressin V2 receptor (sprot)


Q9K2N0_PSEAI Beta-lactamase class B VIM-2 (trembl)


KDM4E_HUMAN Lysine-specific demethylase 4E (sprot)


Carminomycin

A very toxic anthracycline-type antineoplastic related to DAUNORUBICIN, obtained from Actinomadura carminata.


MK03_HUMAN Mitogen-activated protein kinase 3 (sprot)


FAAH1_RAT Fatty-acid amide hydrolase 1 (sprot)


SQOR_HUMAN Sulfide:quinone oxidoreductase, mitochondrial (sprot)


GSHR_HUMAN Glutathione reductase, mitochondrial (sprot)


CPT1A_HUMAN Carnitine O-palmitoyltransferase 1, liver isoform (sprot)


CPT1B_RAT Carnitine O-palmitoyltransferase 1, muscle isoform (sprot)


CPT2_RAT Carnitine O-palmitoyltransferase 2, mitochondrial (sprot)


ANPRA_HUMAN Atrial natriuretic peptide receptor 1 (sprot)


ANPRA_RAT Atrial natriuretic peptide receptor 1 (sprot)


Carprofen

anti-inflammatory drug (NSAID) of the propionic acid class with selective inhibition of COX-2 versus COX-1


5HT4R_CAVPO 5-hydroxytryptamine receptor 4 (sprot)


PK3CD_HUMAN Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (sprot)


PYGM_RABIT Glycogen phosphorylase, muscle form (sprot)


AA1R_BOVIN Adenosine receptor A1 (sprot)


AA1R_CAVPO Adenosine receptor A1 (sprot)


AA2AR_CAVPO Adenosine receptor A2a (sprot)


AA2BR_MOUSE Adenosine receptor A2b (sprot)


CP27B_HUMAN 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial (sprot)


CP2R1_HUMAN Vitamin D 25-hydroxylase (sprot)


VTDB_HUMAN Vitamin D-binding protein (sprot)


VDRA_DANRE Vitamin D3 receptor A (sprot)


TRPA1_MOUSE Transient receptor potential cation channel subfamily A member 1 (sprot)


HGFA_HUMAN Hepatocyte growth factor activator (sprot)


TMPS2_HUMAN Transmembrane protease serine 2 (sprot)


AGTR1_HUMAN Type-1 angiotensin II receptor (sprot)


AGTR1_BOVIN Type-1 angiotensin II receptor (sprot)


AGTR1_RABIT Type-1 angiotensin II receptor (sprot)


ULA1_HUMAN NEDD8-activating enzyme E1 regulatory subunit (sprot)


LKHA4_HUMAN Leukotriene A-4 hydrolase (sprot)


DAPE_HAEIN Succinyl-diaminopimelate desuccinylase (sprot)


BLAN1_KLEPN Metallo-beta-lactamase type 2 (sprot)


KCNKA_HUMAN Potassium channel subfamily K member 10 (sprot)


Cefacetrile

A derivative of 7-aminocephalosporanic acid.


S15A1_HUMAN Solute carrier family 15 member 1 (sprot)


O54286_STAAU Beta-lactam-inducible penicillin-binding protein (trembl)


Q14TG6_HAEIF Peptidoglycan D,D-transpeptidase FtsI (trembl)


Q54906_STRPY Penicillin-binding protein (trembl)


PBPC_BACSU Penicillin-binding protein 3 (sprot)


PLCG1_HUMAN 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 (sprot)


Cefmenoxime

A cephalosporin antibiotic that is administered intravenously or intramuscularly. It is active against most common gram-positive and gram-negative microorganisms, is a potent inhibitor of Enterobacteriaceae, and is highly resistant to hydrolysis by beta-lactamases. The drug has a high rate of efficacy in many types of infection and to date no severe side effects have been noted.


SSR4_HUMAN Somatostatin receptor type 4 (sprot)


COMT_HUMAN Catechol O-methyltransferase (sprot)


Cefotiam

One of the CEPHALOSPORINS that has a broad spectrum of activity against both gram-positive and gram-negative microorganisms.


VIPR1_HUMAN Vasoactive intestinal polypeptide receptor 1 (sprot)


SC6A3_MOUSE Sodium-dependent dopamine transporter (sprot)


Cefsulodin

A pyridinium-substituted semisynthetic, broad-spectrum antibacterial used especially for Pseudomonas infections in debilitated patients.


ARBK1_HUMAN Beta-adrenergic receptor kinase 1 (sprot)


PTN11_HUMAN Tyrosine-protein phosphatase non-receptor type 11 (sprot)


PTN6_HUMAN Tyrosine-protein phosphatase non-receptor type 6 (sprot)


5HT4R_MOUSE 5-hydroxytryptamine receptor 4 (sprot)


SGMR2_RAT Sigma intracellular receptor 2 (sprot)


AROQ_HELPY 3-dehydroquinate dehydratase (sprot)


AROQ_STRCO 3-dehydroquinate dehydratase (sprot)


TRPV4_MOUSE Transient receptor potential cation channel subfamily V member 4 (sprot)


BLKPC_KLEPN Carbapenem-hydrolyzing beta-lactamase KPC (sprot)


Q50H31_BRAPL Class D beta-lactamase (trembl)


Clebopride

antidopaminergic; RN given refers to parent cpd; structure


TRPC4_HUMAN Short transient receptor potential channel 4 (sprot)


TRPC5_HUMAN Short transient receptor potential channel 5 (sprot)


Q1J5W5_STRPF Penicillin-binding protein (trembl)


Q60FU1_HAEIF Peptidoglycan D,D-transpeptidase FtsI (trembl)


Cerulenin

An epoxydodecadienamide isolated from several species, including ACREMONIUM, Acrocylindrum, and Helicoceras. It inhibits the biosynthesis of several lipids by interfering with enzyme function.


F13A_HUMAN Coagulation factor XIII A chain (sprot)


PDE5A_HUMAN cGMP-specific 3',5'-cyclic phosphodiesterase (sprot)


COX2_HUMAN Cytochrome c oxidase subunit 2 (sprot)


PDPK1_HUMAN 3-phosphoinositide-dependent protein kinase 1 (sprot)


PGH2_MOUSE Prostaglandin G/H synthase 2 (sprot)


PGH1_MOUSE Prostaglandin G/H synthase 1 (sprot)


Q8SPQ9_CANLF Prostaglandin G/H synthase 2 (trembl)


PGH2_RAT Prostaglandin G/H synthase 2 (sprot)


PGH1_RAT Prostaglandin G/H synthase 1 (sprot)


PGH1_CANLF Prostaglandin G/H synthase 1 (sprot)


COX2_SHEEP Cytochrome c oxidase subunit 2 (sprot)


PTGES_HUMAN Prostaglandin E synthase (sprot)


COX1_SHEEP Cytochrome c oxidase subunit 1 (sprot)


S15A2_HUMAN Solute carrier family 15 member 2 (sprot)


S22AB_HUMAN Solute carrier family 22 member 11 (sprot)


PTN7_HUMAN Tyrosine-protein phosphatase non-receptor type 7 (sprot)


CCKAR_HUMAN Cholecystokinin receptor type A (sprot)


ADAM9_HUMAN Disintegrin and metalloproteinase domain-containing protein 9 (sprot)


CAT_SALTI Chloramphenicol acetyltransferase (sprot)


TTGR_PSEPK Probable HTH-type transcriptional regulator TtgR (sprot)


BCL2_HUMAN Apoptosis regulator Bcl-2 (sprot)


TRFR_HUMAN Thyrotropin-releasing hormone receptor (sprot)


TRHR_RAT Thyrotropin-releasing hormone receptor (sprot)


TRHR_MOUSE Thyrotropin-releasing hormone receptor (sprot)


GBRA1_BOVIN Gamma-aminobutyric acid receptor subunit alpha-1 (sprot)


GBRB1_BOVIN Gamma-aminobutyric acid receptor subunit beta-1 (sprot)


GBRA2_BOVIN Gamma-aminobutyric acid receptor subunit alpha-2 (sprot)


GBRA3_BOVIN Gamma-aminobutyric acid receptor subunit alpha-3 (sprot)


GBRA4_BOVIN Gamma-aminobutyric acid receptor subunit alpha-4 (sprot)


GBRG2_BOVIN Gamma-aminobutyric acid receptor subunit gamma-2 (sprot)


GASR_HUMAN Gastrin/cholecystokinin type B receptor (sprot)


GASR_RAT Gastrin/cholecystokinin type B receptor (sprot)


S22A3_HUMAN Solute carrier family 22 member 3 (sprot)


RCE1_YEAST CAAX prenyl protease 2 (sprot)


AT1A2_PIG Sodium/potassium-transporting ATPase subunit alpha-2 (sprot)


FAK1_HUMAN Focal adhesion kinase 1 (sprot)


HRP1_PLAFA Histidine-rich protein PFHRP-II (sprot)


RBP_CHICK Riboflavin-binding protein (sprot)


DYR_BOVIN Dihydrofolate reductase (sprot)


Q9N6S8_PLAFA Cysteine proteinase falcipain 2a (trembl)


Q9NAW2_PLAFA Cysteine proteinase falcipain 2a (trembl)


LOX15_HUMAN Polyunsaturated fatty acid lipoxygenase ALOX15 (sprot)


LOX12_HUMAN Polyunsaturated fatty acid lipoxygenase ALOX12 (sprot)


LX15B_HUMAN Polyunsaturated fatty acid lipoxygenase ALOX15B (sprot)


LMBL3_HUMAN Lethal(3)malignant brain tumor-like protein 3 (sprot)


MBTD1_HUMAN MBT domain-containing protein 1 (sprot)


CRT_PLAFA Chloroquine resistance transporter (sprot)


TRPV1_RAT Transient receptor potential cation channel subfamily V member 1 (sprot)


PDR5_YEAST Pleiotropic ABC efflux transporter of multiple drugs (sprot)


NMDZ1_RAT Glutamate receptor ionotropic, NMDA 1 (sprot)


NMDE1_RAT Glutamate receptor ionotropic, NMDA 2A (sprot)


NMDE2_RAT Glutamate receptor ionotropic, NMDA 2B (sprot)


NMDE3_RAT Glutamate receptor ionotropic, NMDA 2C (sprot)


NMDE4_RAT Glutamate receptor ionotropic, NMDA 2D (sprot)


NMD3B_RAT Glutamate receptor ionotropic, NMDA 3B (sprot)


NMD3A_RAT Glutamate receptor ionotropic, NMDA 3A (sprot)


D4A3N4_RAT Adenylate cyclase type 1 (trembl)


Q8CFM9_RAT Adenylyl cyclase 7 (Fragment) (trembl)


ADCY3_RAT Adenylate cyclase type 3 (sprot)


ADCY2_RAT Adenylate cyclase type 2 (sprot)


ADCY4_RAT Adenylate cyclase type 4 (sprot)


ADCY8_RAT Adenylate cyclase type 8 (sprot)


ADCY6_RAT Adenylate cyclase type 6 (sprot)


ADCY5_RAT Adenylate cyclase type 5 (sprot)


ALR_HUMAN FAD-linked sulfhydryl oxidase ALR (sprot)


ASM_HUMAN Sphingomyelin phosphodiesterase (sprot)


AT2A1_RABIT Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 (sprot)


S22A6_RAT Solute carrier family 22 member 6 (sprot)


PADI4_HUMAN Protein-arginine deiminase type-4 (sprot)


NOS1_HUMAN Nitric oxide synthase, brain (sprot)


NOS3_HUMAN Nitric oxide synthase, endothelial (sprot)


NOS1_RAT Nitric oxide synthase, brain (sprot)


KCNN2_RAT Small conductance calcium-activated potassium channel protein 2 (sprot)


UCK1_HUMAN Uridine-cytidine kinase 1 (sprot)


KIT_HUMAN Mast/stem cell growth factor receptor Kit (sprot)


MMP12_HUMAN Macrophage metalloelastase (sprot)


MDR1A_MOUSE ATP-dependent translocase ABCB1 (sprot)


Q4QEW7_LEIMA Dihydroorotate dehydrogenase (fumarate) (trembl)


UCK2_HUMAN Uridine-cytidine kinase 2 (sprot)


PARP1_HUMAN Poly [ADP-ribose] polymerase 1 (sprot)


DOHH_HUMAN Deoxyhypusine hydroxylase (sprot)


CAC1B_HUMAN Voltage-dependent N-type calcium channel subunit alpha-1B (sprot)


CAC1B_RAT Voltage-dependent N-type calcium channel subunit alpha-1B (sprot)


HRH2_CAVPO Histamine H2 receptor (sprot)


CASR_HUMAN Extracellular calcium-sensing receptor (sprot)


GRM5_RAT Metabotropic glutamate receptor 5 (sprot)


CLTR1_CAVPO Cysteinyl leukotriene receptor 1 (sprot)


CLTR1_HUMAN Cysteinyl leukotriene receptor 1 (sprot)


PARC_BACSU DNA topoisomerase 4 subunit A (sprot)


PARC_STAAU DNA topoisomerase 4 subunit A (sprot)


MDTK_ECOLI Multidrug resistance protein MdtK (sprot)


5HT4R_HUMAN 5-hydroxytryptamine receptor 4 (sprot)


5HT3E_HUMAN 5-hydroxytryptamine receptor 3E (sprot)


5HT3B_HUMAN 5-hydroxytryptamine receptor 3B (sprot)


5HT3D_HUMAN 5-hydroxytryptamine receptor 3D (sprot)


5HT3C_HUMAN 5-hydroxytryptamine receptor 3C (sprot)


TRPC3_HUMAN Short transient receptor potential channel 3 (sprot)


TRPC6_HUMAN Short transient receptor potential channel 6 (sprot)


TRPC4_MOUSE Short transient receptor potential channel 4 (sprot)


TRPC5_MOUSE Short transient receptor potential channel 5 (sprot)


TRPC7_MOUSE Short transient receptor potential channel 7 (sprot)


Clenbuterol

A substituted phenylaminoethanol that has beta-2 adrenomimetic properties at very low doses. It is used as a bronchodilator in asthma.


RL10_HALMA 50S ribosomal protein L10 (sprot)


ADT2_HUMAN ADP/ATP translocase 2 (sprot)


ADT1_HUMAN ADP/ATP translocase 1 (sprot)


ADT3_HUMAN ADP/ATP translocase 3 (sprot)


S17A9_HUMAN Solute carrier family 17 member 9 (sprot)


B1LRJ1_ECOSM Type IV secretion-like conjugative transfer relaxase protein TraI (trembl)


DPOLA_HUMAN DNA polymerase alpha catalytic subunit (sprot)


RIR1_HUMAN Ribonucleoside-diphosphate reductase large subunit (sprot)


RIR2_HUMAN Ribonucleoside-diphosphate reductase subunit M2 (sprot)


PRPS1_HUMAN Ribose-phosphate pyrophosphokinase 1 (sprot)


CZCO_GEOKA Uncharacterized oxidoreductase CzcO-like (sprot)


Clofibric acid

An antilipemic agent that is the biologically active metabolite of CLOFIBRATE.


PPARA_MOUSE Peroxisome proliferator-activated receptor alpha (sprot)


PTGDS_MOUSE Prostaglandin-H2 D-isomerase (sprot)


GSTP1_HUMAN Glutathione S-transferase P (sprot)


TYTR_TRYBB Trypanothione reductase (sprot)


GBRP_HUMAN Gamma-aminobutyric acid receptor subunit pi (sprot)


GBRE_HUMAN Gamma-aminobutyric acid receptor subunit epsilon (sprot)


GBRT_HUMAN Gamma-aminobutyric acid receptor subunit theta (sprot)


HCN1_MOUSE Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 (sprot)


HCN2_MOUSE Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 (sprot)


HCN4_MOUSE Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 (sprot)


KCNA3_HUMAN Potassium voltage-gated channel subfamily A member 3 (sprot)


CP51_MYCTU Lanosterol 14-alpha demethylase (sprot)


CXCR1_HUMAN C-X-C chemokine receptor type 1 (sprot)


CP51A_ASPFU Sterol 14-alpha demethylase cyp51A (sprot)


Q96W81_ASPFM 14-alpha sterol demethylase (trembl)


I23O2_MOUSE Indoleamine 2,3-dioxygenase 2 (sprot)


CP121_MYCTU Mycocyclosin synthase (sprot)


TERA_HUMAN Transitional endoplasmic reticulum ATPase (sprot)


MDHC_HUMAN Malate dehydrogenase, cytoplasmic (sprot)


I23O1_MOUSE Indoleamine 2,3-dioxygenase 1 (sprot)


CP8B1_HUMAN 7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase (sprot)


P72355_STAAU Penicillin-binding protein 4 (trembl)


Q53707_STAAU MecA PBP2' (penicillin binding protein 2') (trembl)


Q53725_STAAU Cell division protein FtsI (Peptidoglycan synthetase) (trembl)


Q53729_STAAU Penicillin-binding protein 2 (trembl)


Q9XDB3_STAAU Cell division protein FtsI [Peptidoglycan synthetase] / Transpeptidase, Penicillin binding protein transpeptidase domain, Penicillin-binding protein 3 (trembl)


UD14_HUMAN UDP-glucuronosyltransferase 1A4 (sprot)


DRD2_MOUSE D(2) dopamine receptor (sprot)


5HT1A_MOUSE 5-hydroxytryptamine receptor 1A (sprot)


DRD2_CHLAE D(2) dopamine receptor (sprot)


5HT3A_MOUSE 5-hydroxytryptamine receptor 3A (sprot)


DRD1_PIG D(1A) dopamine receptor (sprot)


DRD3_CHLAE D(3) dopamine receptor (sprot)


HRH4_MOUSE Histamine H4 receptor (sprot)


5HT2C_MOUSE 5-hydroxytryptamine receptor 2C (sprot)


5HT2A_MOUSE 5-hydroxytryptamine receptor 2A (sprot)


5HT2B_MOUSE 5-hydroxytryptamine receptor 2B (sprot)


5HT5A_MOUSE 5-hydroxytryptamine receptor 5A (sprot)


SC6A3_BOVIN Sodium-dependent dopamine transporter (sprot)


SC6A3_MACFA Sodium-dependent dopamine transporter (sprot)


GLRA2_HUMAN Glycine receptor subunit alpha-2 (sprot)


PIM1_HUMAN Serine/threonine-protein kinase pim-1 (sprot)


TBA1A_PIG Tubulin alpha-1A chain (sprot)


TBB2B_BOVIN Tubulin beta-2B chain (sprot)


TPPP_BOVIN Tubulin polymerization-promoting protein (sprot)


Q862F3_BOVIN Similar to alpha-tubulin isoform 1 (Fragment) (trembl)


Q862L2_BOVIN Similar to alpha-tubulin isoform 1 (Fragment) (trembl)


Colforsin daropate

Potent activator of the adenylate cyclase system and the biosynthesis of cyclic AMP. From the plant COLEUS FORSKOHLII. Has antihypertensive, positive inotropic, platelet aggregation inhibitory, and smooth muscle relaxant activities; also lowers intraocular pressure and promotes release of hormones from the pituitary gland.


ADCY1_HUMAN Adenylate cyclase type 1 (sprot)


GTR1_HUMAN Solute carrier family 2, facilitated glucose transporter member 1 (sprot)


ADCY1_BOVIN Adenylate cyclase type 1 (sprot)


ADCY8_HUMAN Adenylate cyclase type 8 (sprot)


V1AR_RAT Vasopressin V1a receptor (sprot)


KCNA1_HUMAN Potassium voltage-gated channel subfamily A member 1 (sprot)


FNTA_HUMAN Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha (sprot)


Cotinine

The N-glucuronide conjugate of cotinine is a major urinary metabolite of NICOTINE. It thus serves as a biomarker of exposure to tobacco SMOKING. It has CNS stimulating properties.


Coumarin

effective in reducing edema following crush & thermal injury; structure in Merck Index, 9th ed, #2547; Coumarin itself occurs in the Tonka bean


MCL1_HUMAN Induced myeloid leukemia cell differentiation protein Mcl-1 (sprot)


SETD7_HUMAN Histone-lysine N-methyltransferase SETD7 (sprot)


PPAP_HUMAN Prostatic acid phosphatase (sprot)


DPOD1_HUMAN DNA polymerase delta catalytic subunit (sprot)


DPOE1_HUMAN DNA polymerase epsilon catalytic subunit A (sprot)


DPOA2_HUMAN DNA polymerase alpha subunit B (sprot)


GRB2_HUMAN Growth factor receptor-bound protein 2 (sprot)


DDR2_HUMAN Discoidin domain-containing receptor 2 (sprot)


GRB2_MOUSE Growth factor receptor-bound protein 2 (sprot)


NGLY1_HUMAN Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase (sprot)


PROC_HUMAN Vitamin K-dependent protein C (sprot)


Q28731_RABIT Thrombin (Fragment) (trembl)


CISD1_HUMAN CDGSH iron-sulfur domain-containing protein 1 (sprot)


AOFB_RAT Amine oxidase [flavin-containing] B (sprot)


Q33BM1_RAT G protein-coupled receptor GPR35 (trembl)


GPR35_MOUSE G-protein coupled receptor 35 (sprot)


Cyclofenil

A gonadal stimulant and inducer of ovulation. It is used in the treatment of infertility and amenorrhea, but is thought to be less effective than CLOMIPHENE.


Cycloguanil

the active metabolite of proguanil; antifolate drug


DRTS_PLAFK Bifunctional dihydrofolate reductase-thymidylate synthase (sprot)


DDL_MYCTU D-alanine--D-alanine ligase (sprot)


FKB1A_HUMAN Peptidyl-prolyl cis-trans isomerase FKBP1A (sprot)


PPIA_HUMAN Peptidyl-prolyl cis-trans isomerase A (sprot)


FPR1_HUMAN fMet-Leu-Phe receptor (sprot)


SO1B1_HUMAN Solute carrier organic anion transporter family member 1B1 (sprot)


FKBP4_HUMAN Peptidyl-prolyl cis-trans isomerase FKBP4 (sprot)


PPIB_HUMAN Peptidyl-prolyl cis-trans isomerase B (sprot)


PP2BA_HUMAN Protein phosphatase 3 catalytic subunit alpha (sprot)


FKB1B_HUMAN Peptidyl-prolyl cis-trans isomerase FKBP1B (sprot)


PPID_HUMAN Peptidyl-prolyl cis-trans isomerase D (sprot)


SO1B3_HUMAN Solute carrier organic anion transporter family member 1B3 (sprot)


NTCP_HUMAN Hepatic sodium/bile acid cotransporter (sprot)


PK3CG_MOUSE Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (sprot)


Cyclothiazide

inhibits the desensitization of AMPA-type receptors; structure


GRIA1_HUMAN Glutamate receptor 1 (sprot)


GRIA2_HUMAN Glutamate receptor 2 (sprot)


GRIA4_HUMAN Glutamate receptor 4 (sprot)


GRIA3_HUMAN Glutamate receptor 3 (sprot)


Q7ZJM1_9HIV1 Integrase (Fragment) (trembl)


JUN_HUMAN Transcription factor Jun (sprot)


DEPTROPINE

minor descriptor (65-85); on-line & Index Medicus search TROPANES (66-85); RN given refers to parent cpd


Q8WSF8_APLCA Soluble acetylcholine receptor (trembl)


KCNK9_HUMAN Potassium channel subfamily K member 9 (sprot)


KCNKI_HUMAN Potassium channel subfamily K member 18 (sprot)


GLRB_HUMAN Glycine receptor subunit beta (sprot)


S29A4_HUMAN Equilibrative nucleoside transporter 4 (sprot)


KCNJ5_MOUSE G protein-activated inward rectifier potassium channel 4 (sprot)


Deslanoside

Deacetyllanatoside C. A cardiotonic glycoside from the leaves of Digitalis lanata.


GBRR2_HUMAN Gamma-aminobutyric acid receptor subunit rho-2 (sprot)


A2AMW3_MOUSE Gamma-aminobutyric acid (GABA) A receptor, subunit epsilon (trembl)


GBRA6_MOUSE Gamma-aminobutyric acid receptor subunit alpha-6 (sprot)


GBRG2_MOUSE Gamma-aminobutyric acid receptor subunit gamma-2 (sprot)


GBRD_MOUSE Gamma-aminobutyric acid receptor subunit delta (sprot)


GBRA2_MOUSE Gamma-aminobutyric acid receptor subunit alpha-2 (sprot)


GBRA3_MOUSE Gamma-aminobutyric acid receptor subunit alpha-3 (sprot)


GBRG3_MOUSE Gamma-aminobutyric acid receptor subunit gamma-3 (sprot)


GBRB1_MOUSE Gamma-aminobutyric acid receptor subunit beta-1 (sprot)


GBRA1_MOUSE Gamma-aminobutyric acid receptor subunit alpha-1 (sprot)


GBRB3_MOUSE Gamma-aminobutyric acid receptor subunit beta-3 (sprot)


GBRA5_MOUSE Gamma-aminobutyric acid receptor subunit alpha-5 (sprot)


GBRP_MOUSE Gamma-aminobutyric acid receptor subunit pi (sprot)


GBRA4_MOUSE Gamma-aminobutyric acid receptor subunit alpha-4 (sprot)


GBRT_MOUSE Gamma-aminobutyric acid receptor subunit theta (sprot)


GBRG1_MOUSE Gamma-aminobutyric acid receptor subunit gamma-1 (sprot)


V1BR_HUMAN Vasopressin V1b receptor (sprot)


V1BR_RAT Vasopressin V1b receptor (sprot)


Desoxycortone

A steroid metabolite that is the 11-deoxy derivative of CORTICOSTERONE and the 21-hydroxy derivative of PROGESTERONE


Deoxycorticosterone acetate

The 21-acetate derivative of desoxycorticosterone.


DHPS1_MYCLE Dihydropteroate synthase (sprot)


G6PD_HUMAN Glucose-6-phosphate 1-dehydrogenase (sprot)


OMPD_SALCH Outer membrane porin protein OmpD (sprot)


JAK3_HUMAN Tyrosine-protein kinase JAK3 (sprot)


PGFRB_HUMAN Platelet-derived growth factor receptor beta (sprot)


ABL1_HUMAN Tyrosine-protein kinase ABL1 (sprot)


MTOR_HUMAN Serine/threonine-protein kinase mTOR (sprot)


BCR_HUMAN Breakpoint cluster region protein (sprot)


YES_HUMAN Tyrosine-protein kinase Yes (sprot)


EPHA2_HUMAN Ephrin type-A receptor 2 (sprot)


RAF1_HUMAN RAF proto-oncogene serine/threonine-protein kinase (sprot)


BRAF_HUMAN Serine/threonine-protein kinase B-raf (sprot)


FLT3_HUMAN Receptor-type tyrosine-protein kinase FLT3 (sprot)


VGFR1_HUMAN Vascular endothelial growth factor receptor 1 (sprot)


VGFR2_HUMAN Vascular endothelial growth factor receptor 2 (sprot)


CSF1R_HUMAN Macrophage colony-stimulating factor 1 receptor (sprot)


PGFRA_HUMAN Platelet-derived growth factor receptor alpha (sprot)


MYLK_HUMAN Myosin light chain kinase, smooth muscle (sprot)


FGFR3_HUMAN Fibroblast growth factor receptor 3 (sprot)


HCK_HUMAN Tyrosine-protein kinase HCK (sprot)


ERBB4_HUMAN Receptor tyrosine-protein kinase erbB-4 (sprot)


KAPCB_HUMAN cAMP-dependent protein kinase catalytic subunit beta (sprot)


KSYK_HUMAN Tyrosine-protein kinase SYK (sprot)


MYLK2_HUMAN Myosin light chain kinase 2, skeletal/cardiac muscle (sprot)


CSK_HUMAN Tyrosine-protein kinase CSK (sprot)


EPHA8_HUMAN Ephrin type-A receptor 8 (sprot)


LYN_HUMAN Tyrosine-protein kinase Lyn (sprot)


BMX_HUMAN Cytoplasmic tyrosine-protein kinase BMX (sprot)


NEK2_HUMAN Serine/threonine-protein kinase Nek2 (sprot)


FGFR1_HUMAN Fibroblast growth factor receptor 1 (sprot)


STK10_HUMAN Serine/threonine-protein kinase 10 (sprot)


ABL2_HUMAN Tyrosine-protein kinase ABL2 (sprot)


MK11_HUMAN Mitogen-activated protein kinase 11 (sprot)


EPHA5_HUMAN Ephrin type-A receptor 5 (sprot)


EPHA4_HUMAN Ephrin type-A receptor 4 (sprot)


FGFR2_HUMAN Fibroblast growth factor receptor 2 (sprot)


PKN1_HUMAN Serine/threonine-protein kinase N1 (sprot)


KPCT_HUMAN Protein kinase C theta type (sprot)


EPHA6_HUMAN Ephrin type-A receptor 6 (sprot)


TNIK_HUMAN TRAF2 and NCK-interacting protein kinase (sprot)


KC1E_HUMAN Casein kinase I isoform epsilon (sprot)


FGR_HUMAN Tyrosine-protein kinase Fgr (sprot)


STK36_HUMAN Serine/threonine-protein kinase 36 (sprot)


EPHA3_HUMAN Ephrin type-A receptor 3 (sprot)


FRK_HUMAN Tyrosine-protein kinase FRK (sprot)


M4K5_HUMAN Mitogen-activated protein kinase kinase kinase kinase 5 (sprot)


M3K4_HUMAN Mitogen-activated protein kinase kinase kinase 4 (sprot)


GAK_HUMAN Cyclin-G-associated kinase (sprot)


RIPK2_HUMAN Receptor-interacting serine/threonine-protein kinase 2 (sprot)


EPHB1_HUMAN Ephrin type-B receptor 1 (sprot)


STK4_HUMAN Serine/threonine-protein kinase 4 (sprot)


ACK1_HUMAN Activated CDC42 kinase 1 (sprot)


SLK_HUMAN STE20-like serine/threonine-protein kinase (sprot)


DDR1_HUMAN Epithelial discoidin domain-containing receptor 1 (sprot)


EPHB4_HUMAN Ephrin type-B receptor 4 (sprot)


ACV1B_HUMAN Activin receptor type-1B (sprot)


ACVL1_HUMAN Serine/threonine-protein kinase receptor R3 (sprot)


ACVR1_HUMAN Activin receptor type-1 (sprot)


TGFR2_HUMAN TGF-beta receptor type-2 (sprot)


MP2K1_HUMAN Dual specificity mitogen-activated protein kinase kinase 1 (sprot)


MP2K2_HUMAN Dual specificity mitogen-activated protein kinase kinase 2 (sprot)


ITK_HUMAN Tyrosine-protein kinase ITK/TSK (sprot)


PTK6_HUMAN Protein-tyrosine kinase 6 (sprot)


LCK_MOUSE Proto-oncogene tyrosine-protein kinase LCK (sprot)


BTK_HUMAN Tyrosine-protein kinase BTK (sprot)


TEC_HUMAN Tyrosine-protein kinase Tec (sprot)


EPHB2_HUMAN Ephrin type-B receptor 2 (sprot)


TNK1_HUMAN Non-receptor tyrosine-protein kinase TNK1 (sprot)


TYK2_HUMAN Non-receptor tyrosine-protein kinase TYK2 (sprot)


PK3CA_HUMAN Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (sprot)


SRC_CHICK Proto-oncogene tyrosine-protein kinase Src (sprot)


WEE1_HUMAN Wee1-like protein kinase (sprot)


STK25_HUMAN Serine/threonine-protein kinase 25 (sprot)


M3K20_HUMAN Mitogen-activated protein kinase kinase kinase 20 (sprot)


TXK_HUMAN Tyrosine-protein kinase TXK (sprot)


STK26_HUMAN Serine/threonine-protein kinase 26 (sprot)


NLK_HUMAN Serine/threonine-protein kinase NLK (sprot)


E2AK4_HUMAN eIF-2-alpha kinase GCN2 (sprot)


SIK2_HUMAN Serine/threonine-protein kinase SIK2 (sprot)


AVR2A_HUMAN Activin receptor type-2A (sprot)


AVR2B_HUMAN Activin receptor type-2B (sprot)


TNI3K_HUMAN Serine/threonine-protein kinase TNNI3K (sprot)


DMPK_HUMAN Myotonin-protein kinase (sprot)


COQ8A_HUMAN Atypical kinase COQ8A, mitochondrial (sprot)


MRCKG_HUMAN Serine/threonine-protein kinase MRCK gamma (sprot)


M4K1_HUMAN Mitogen-activated protein kinase kinase kinase kinase 1 (sprot)


PMYT1_HUMAN Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase (sprot)


M4K3_HUMAN Mitogen-activated protein kinase kinase kinase kinase 3 (sprot)


BLK_HUMAN Tyrosine-protein kinase Blk (sprot)


BMR1A_HUMAN Bone morphogenetic protein receptor type-1A (sprot)


M4K4_HUMAN Mitogen-activated protein kinase kinase kinase kinase 4 (sprot)


MRCKA_HUMAN Serine/threonine-protein kinase MRCK alpha (sprot)


MRCKB_HUMAN Serine/threonine-protein kinase MRCK beta (sprot)


PAK4_HUMAN Serine/threonine-protein kinase PAK 4 (sprot)


SIK1_HUMAN Serine/threonine-protein kinase SIK1 (sprot)


SRMS_HUMAN Tyrosine-protein kinase Srms (sprot)


TESK1_HUMAN Dual specificity testis-specific protein kinase 1 (sprot)


TGFR1_HUMAN TGF-beta receptor type-1 (sprot)


EPHA1_HUMAN Ephrin type-A receptor 1 (sprot)


EPHB3_HUMAN Ephrin type-B receptor 3 (sprot)


TBA1A_RAT Tubulin alpha-1A chain (sprot)


M4K2_HUMAN Mitogen-activated protein kinase kinase kinase kinase 2 (sprot)


MINK1_HUMAN Misshapen-like kinase 1 (sprot)


BLK_MOUSE Tyrosine-protein kinase Blk (sprot)


EPHB6_HUMAN Ephrin type-B receptor 6 (sprot)


M3K13_HUMAN Mitogen-activated protein kinase kinase kinase 13 (sprot)


M3K2_HUMAN Mitogen-activated protein kinase kinase kinase 2 (sprot)


M3K3_HUMAN Mitogen-activated protein kinase kinase kinase 3 (sprot)


TAOK3_HUMAN Serine/threonine-protein kinase TAO3 (sprot)


ULK3_HUMAN Serine/threonine-protein kinase ULK3 (sprot)


M3K19_HUMAN Mitogen-activated protein kinase kinase kinase 19 (sprot)


STK35_HUMAN Serine/threonine-protein kinase 35 (sprot)


ERBB3_HUMAN Receptor tyrosine-protein kinase erbB-3 (sprot)


M3K1_HUMAN Mitogen-activated protein kinase kinase kinase 1 (sprot)


SIK3_HUMAN Serine/threonine-protein kinase SIK3 (sprot)


WEE2_HUMAN Wee1-like protein kinase 2 (sprot)


BMR1B_HUMAN Bone morphogenetic protein receptor type-1B (sprot)


NORA_STAAU Quinolone resistance protein NorA (sprot)


SBK1_HUMAN Serine/threonine-protein kinase SBK1 (sprot)


VRK2_HUMAN Serine/threonine-protein kinase VRK2 (sprot)


TAOK2_HUMAN Serine/threonine-protein kinase TAO2 (sprot)


MP2K5_HUMAN Dual specificity mitogen-activated protein kinase kinase 5 (sprot)


NEK11_HUMAN Serine/threonine-protein kinase Nek11 (sprot)


CDPK1_PLAF7 Calcium-dependent protein kinase 1 (sprot)


MK13_HUMAN Mitogen-activated protein kinase 13 (sprot)


MK12_HUMAN Mitogen-activated protein kinase 12 (sprot)


MYT1_HUMAN Myelin transcription factor 1 (sprot)


MRP6_HUMAN ATP-binding cassette sub-family C member 6 (sprot)


Deanol

An antidepressive agent that has also been used in the treatment of movement disorders. The mechanism of action is not well understood.


SC5A7_MOUSE High affinity choline transporter 1 (sprot)


SC6A8_RAT Sodium- and chloride-dependent creatine transporter 1 (sprot)


Debrisoquine

An adrenergic neuron-blocking drug similar in effects to GUANETHIDINE. It is also noteworthy in being a substrate for a polymorphic cytochrome P-450 enzyme. Persons with certain isoforms of this enzyme are unable to properly metabolize this and many other clinically important drugs. They are commonly referred to as having a debrisoquin 4-hydroxylase polymorphism.


ACHG_HUMAN Acetylcholine receptor subunit gamma (sprot)


ACHE_HUMAN Acetylcholine receptor subunit epsilon (sprot)


HIF1A_HUMAN Hypoxia-inducible factor 1-alpha (sprot)


Q9GRG7_9TRYP Glucose-6-phosphate 1-dehydrogenase (trembl)


Demecarium

major descriptor (65-85); on-line search AMMONIUM COMPOUNDS (66-85); Index Medicus search DEMECARIUM BROMIDE (65-85)


RS4_ECOLI 30S ribosomal protein S4 (sprot)


RS9_ECOLI 30S ribosomal protein S9 (sprot)


SGMR1_CAVPO Sigma non-opioid intracellular receptor 1 (sprot)


SCN1A_RAT Sodium channel protein type 1 subunit alpha (sprot)


SCN2A_RAT Sodium channel protein type 2 subunit alpha (sprot)


SCN3A_RAT Sodium channel protein type 3 subunit alpha (sprot)


T2R46_HUMAN Taste receptor type 2 member 46 (sprot)


THB_RAT Thyroid hormone receptor beta (sprot)


GLD1_CAEEL Female germline-specific tumor suppressor gld-1 (sprot)


NAAA_HUMAN N-acylethanolamine-hydrolyzing acid amidase (sprot)


AK1C2_HUMAN Aldo-keto reductase family 1 member C2 (sprot)


NAMPT_HUMAN Nicotinamide phosphoribosyltransferase (sprot)


KCJ11_MOUSE ATP-sensitive inward rectifier potassium channel 11 (sprot)


Dibekacin

Analog of KANAMYCIN with antitubercular as well as broad-spectrum antimicrobial properties.


PDK1_HUMAN [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial (sprot)


PDK2_HUMAN [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial (sprot)


PDK3_HUMAN [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 3, mitochondrial (sprot)


PDK4_HUMAN [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial (sprot)


BIP_HUMAN Endoplasmic reticulum chaperone BiP (sprot)


NR1I2_MOUSE Nuclear receptor subfamily 1 group I member 2 (sprot)


Dexamethasone palmitate

a liposteroid for treatment of hemophagocytic lymphohistiocytosis


ACM4_MOUSE Muscarinic acetylcholine receptor M4 (sprot)


ACM5_MOUSE Muscarinic acetylcholine receptor M5 (sprot)


ACM3_MOUSE Muscarinic acetylcholine receptor M3 (sprot)


Dexloxiglumide

a CCK receptor antagonist; structure given in first source


CAC1D_RAT Voltage-dependent L-type calcium channel subunit alpha-1D (sprot)


TAAR1_MACMU Trace amine-associated receptor 1 (sprot)


TAAR1_RAT Trace amine-associated receptor 1 (sprot)


TAAR1_MOUSE Trace amine-associated receptor 1 (sprot)


AK1BA_HUMAN Aldo-keto reductase family 1 member B10 (sprot)


UD17_HUMAN UDP-glucuronosyltransferase 1A7 (sprot)


UD16_HUMAN UDP-glucuronosyltransferase 1-6 (sprot)


UD19_HUMAN UDP-glucuronosyltransferase 1A9 (sprot)


UD110_HUMAN UDP-glucuronosyltransferase 1A10 (sprot)


TRPM3_HUMAN Transient receptor potential cation channel subfamily M member 3 (sprot)


PCSK7_HUMAN Proprotein convertase subtilisin/kexin type 7 (sprot)


HIS1_MYCTU ATP phosphoribosyltransferase (sprot)


NQO1_RAT NAD(P)H dehydrogenase [quinone] 1 (sprot)


Q72549_9HIV1 Reverse transcriptase/RNaseH (Fragment) (trembl)


Diethazine

phenothiazine derivative anti-Parkinson agent with anticholinergic and antihistaminic actions; is effective against Parkinson tremor; minor descriptor (75-86); on-line & INDEX MEDICUS search PHENOTHIAZINES (75-86); RN given refers to cpd without isomeric designation


ERR3_HUMAN Estrogen-related receptor gamma (sprot)


ERR2_HUMAN Steroid hormone receptor ERR2 (sprot)


GALE_HUMAN UDP-glucose 4-epimerase (sprot)


ERR1_MOUSE Steroid hormone receptor ERR1 (sprot)


ACMSD_HUMAN 2-amino-3-carboxymuconate-6-semialdehyde decarboxylase (sprot)


AT1A1_CANLF Sodium/potassium-transporting ATPase subunit alpha-1 (sprot)


STAT3_HUMAN Signal transducer and activator of transcription 3 (sprot)


RORG_HUMAN Nuclear receptor ROR-gamma (sprot)


RORG_MOUSE Nuclear receptor ROR-gamma (sprot)


alpha-Ergocryptine

a component of the ergotoxine complex; it is the main ergot alkaloid of Japanese & South American wid grasses; minor descriptor (76-86); on-line & INDEX MEDICUS search ERGOLINES (76-86); RN given refers to ((5'alpha)-isomer)


Dihydroergocristine

A 9,10alpha-dihydro derivative of ERGOTAMINE that contains an isopropyl sidechain at the 2' position of the molecule.


GASR_MOUSE Gastrin/cholecystokinin type B receptor (sprot)


Dihydroquinidine

urinary quinine metabolite; RN given refers to (9S)-isomer; structure in Merck Index, 9th ed, #4703


SCN1B_HUMAN Sodium channel subunit beta-1 (sprot)


SCN2B_HUMAN Sodium channel subunit beta-2 (sprot)


SCN3B_HUMAN Sodium channel subunit beta-3 (sprot)


SCN4B_HUMAN Sodium channel subunit beta-4 (sprot)


Dilazep

Coronary vasodilator with some antiarrhythmic activity.


S29A1_HUMAN Equilibrative nucleoside transporter 1 (sprot)


S29A2_RAT Equilibrative nucleoside transporter 2 (sprot)


CAC1S_HUMAN Voltage-dependent L-type calcium channel subunit alpha-1S (sprot)


KCNC1_MOUSE Potassium voltage-gated channel subfamily C member 1 (sprot)


KCNA7_MOUSE Potassium voltage-gated channel subfamily A member 7 (sprot)


CAC1F_MOUSE Voltage-dependent L-type calcium channel subunit alpha-1F (sprot)


Dimetacrine

minor descriptor (75-84); on-line & Index Medicus search ACRIDINES (75-84); RN given refers to parent cpd without isomeric designation


Q7KQK5_PLAF7 Apical membrane antigen 1 (trembl)


A4TVL0_9PROT Cereblon isoform 4 (trembl)


MAP2_HUMAN Methionine aminopeptidase 2 (sprot)


MAP11_HUMAN Methionine aminopeptidase 1 (sprot)


PD2R2_HUMAN Prostaglandin D2 receptor 2 (sprot)


TA2R_HUMAN Thromboxane A2 receptor (sprot)


PF2R_BOVIN Prostaglandin F2-alpha receptor (sprot)


PF2R_MOUSE Prostaglandin F2-alpha receptor (sprot)


PD2R2_MOUSE Prostaglandin D2 receptor 2 (sprot)


S22AK_MOUSE Solute carrier family 22 member 20 (sprot)


PDE11_HUMAN Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A (sprot)


PDE10_HUMAN cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (sprot)


PDE8B_HUMAN High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B (sprot)


PDE7B_HUMAN cAMP-specific 3',5'-cyclic phosphodiesterase 7B (sprot)


PDE8A_HUMAN High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A (sprot)


O77823_PIG 3',5'-cyclic-AMP phosphodiesterase (Fragment) (trembl)


PDE7A_HUMAN High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A (sprot)


PDE6D_HUMAN Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta (sprot)


CNRG_HUMAN Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma (sprot)


CNCG_HUMAN Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma (sprot)


PDE6A_HUMAN Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha (sprot)


PDE6B_HUMAN Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta (sprot)


PDE6C_HUMAN Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' (sprot)


PDE1A_HUMAN Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A (sprot)


PDE1B_HUMAN Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B (sprot)


PDE1C_HUMAN Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C (sprot)


PRUN1_HUMAN Exopolyphosphatase PRUNE1 (sprot)


R1AB_SARS2 Replicase polyprotein 1ab (sprot)


ALDH2_HUMAN Aldehyde dehydrogenase, mitochondrial (sprot)


CCR5_HUMAN C-C chemokine receptor type 5 (sprot)


CXCR2_HUMAN C-X-C chemokine receptor type 2 (sprot)


ALDH2_RAT Aldehyde dehydrogenase, mitochondrial (sprot)


GLMU_MYCTU Bifunctional protein GlmU (sprot)


LYOX_HUMAN Protein-lysine 6-oxidase (sprot)


LOXL3_HUMAN Lysyl oxidase homolog 3 (sprot)


LOXL4_HUMAN Lysyl oxidase homolog 4 (sprot)


EHMT2_HUMAN Histone-lysine N-methyltransferase EHMT2 (sprot)


EHMT1_HUMAN Histone-lysine N-methyltransferase EHMT1 (sprot)


LOXL2_HUMAN Lysyl oxidase homolog 2 (sprot)


Diethyldithiocarbamic acid

A chelating agent that has been used to mobilize toxic metals from the tissues of humans and experimental animals. It is the main metabolite of DISULFIRAM.


TRPM8_MOUSE Transient receptor potential cation channel subfamily M member 8 (sprot)


TRPM8_RAT Transient receptor potential cation channel subfamily M member 8 (sprot)


TRPM8_HUMAN Transient receptor potential cation channel subfamily M member 8 (sprot)


GHRHR_HUMAN Growth hormone-releasing hormone receptor (sprot)


TBB4A_HUMAN Tubulin beta-4A chain (sprot)


TBB2A_HUMAN Tubulin beta-2A chain (sprot)


TBB2B_HUMAN Tubulin beta-2B chain (sprot)


NOD2_HUMAN Nucleotide-binding oligomerization domain-containing protein 2 (sprot)


GN_HHV11 Envelope glycoprotein N (sprot)


GM_HHV11 Envelope glycoprotein M (sprot)


GE_HHV11 Envelope glycoprotein E (sprot)


GH_HHV11 Envelope glycoprotein H (sprot)


GJ_HHV11 Envelope glycoprotein J (sprot)


GG_HHV11 Envelope glycoprotein G (sprot)


GI_HHV11 Envelope glycoprotein I (sprot)


GL_HHV11 Envelope glycoprotein L (sprot)


GB_HHV11 Envelope glycoprotein B (sprot)


GC_HHV11 Envelope glycoprotein C (sprot)


GK_HHV11 Envelope glycoprotein K (sprot)


GD_HHV11 Envelope glycoprotein D (sprot)


CLAT_RAT Choline O-acetyltransferase (sprot)


Q9JKC1_RAT Carboxylic ester hydrolase (trembl)


Q9N1N9_HORSE Carboxylic ester hydrolase (trembl)


ADRB2_CANLF Beta-2 adrenergic receptor (sprot)


DOPO_HUMAN Dopamine beta-hydroxylase (sprot)


MMP8_HUMAN Neutrophil collagenase (sprot)


Q8I2J3_PLAF7 M18 aspartyl aminopeptidase (trembl)


TERT_HUMAN Telomerase reverse transcriptase (sprot)


RNAS1_BOVIN Ribonuclease pancreatic (sprot)


T2D3_HAEIN Type II restriction enzyme HindIII (sprot)


T2S1_STRCS Type II restriction enzyme ScaI (sprot)


GLF_MYCTU UDP-galactopyranose mutase (sprot)


DNM3A_MOUSE DNA (cytosine-5)-methyltransferase 3A (sprot)


TCR2_ECOLX Tetracycline resistance protein, class B (sprot)


Drotaverine

Hungarian drug; RN given refers to parent cpd; structure


GSTA1_HUMAN Glutathione S-transferase A1 (sprot)


GLYM_HUMAN Serine hydroxymethyltransferase, mitochondrial (sprot)


S5A1_HUMAN 3-oxo-5-alpha-steroid 4-dehydrogenase 1 (sprot)


NR2E1_HUMAN Nuclear receptor subfamily 2 group E member 1 (sprot)


Ebrotidine

an H2-receptor antagonist and gastric mucosa protector


NPY2R_HUMAN Neuropeptide Y receptor type 2 (sprot)


CRCM1_HUMAN Calcium release-activated calcium channel protein 1 (sprot)


FOLC_HUMAN Folylpolyglutamate synthase, mitochondrial (sprot)


CEGT_HUMAN Ceramide glucosyltransferase (sprot)


Q9XAY4_PSEAI Beta-lactamase VIM-1 (trembl)


Q9WJQ2_9HIV1 Reverse transcriptase protein (Fragment) (trembl)


CP46A_HUMAN Cholesterol 24-hydroxylase (sprot)


DCOR_HUMAN Ornithine decarboxylase (sprot)


DCOR_RAT Ornithine decarboxylase (sprot)


Q9TZZ6_TRYBG Ornithine decarboxylase (trembl)


CAC1G_RAT Voltage-dependent T-type calcium channel subunit alpha-1G (sprot)


Elliptinium

synthetic ellipticine deriv; RN given refers to parent cpd; structure given in first source


Pregnanolone

A pregnane found in the urine of pregnant women and sows. It has anesthetic, hypnotic, and sedative properties.


Emetine

The principal alkaloid of ipecac, from the ground roots of Uragoga (or Cephaelis) ipecacuanha or U. acuminata, of the Rubiaceae. It is used as an amebicide in many different preparations and may cause serious cardiac, hepatic, or renal damage and violent diarrhea and vomiting. Emetine inhibits protein synthesis in EUKARYOTIC CELLS but not PROKARYOTIC CELLS.


RBBP9_HUMAN Serine hydrolase RBBP9 (sprot)


A0A143MHK7_ZIKV Genome polyprotein (Fragment) (trembl)


ACE2_RAT Angiotensin-converting enzyme 2 (sprot)


ACE_MOUSE Angiotensin-converting enzyme (sprot)


Q53I07_9HIV1 Env polyprotein (Fragment) (trembl)


O40239_9PLVG Env polyprotein (Fragment) (trembl)


Q76270_9HIV1 Env polyprotein (Fragment) (trembl)


VATB2_HUMAN V-type proton ATPase subunit B, brain isoform (sprot)


PARC_NEIGO DNA topoisomerase 4 subunit A (sprot)


TRBP2_HUMAN RISC-loading complex subunit TARBP2 (sprot)


Enoximone

A selective phosphodiesterase inhibitor with vasodilating and positive inotropic activity that does not cause changes in myocardial oxygen consumption. It is used in patients with CONGESTIVE HEART FAILURE.


4,5-Heptadienoic acid, 7-(3-hydroxy-2-(3-hydroxy-4-phenoxy-1-butenyl)-5-oxocyclopentyl)-, methyl ester

A synthetic PGE2 analog that has an inhibitory effect on gastric acid secretion, a mucoprotective effect, and a postprandial lowering effect on gastrin. It has been shown to be efficient and safe in the treatment of gastroduodenal ulcers.


FTO_HUMAN Alpha-ketoglutarate-dependent dioxygenase FTO (sprot)


AK1A1_HUMAN Aldo-keto reductase family 1 member A1 (sprot)


AK1A1_PIG Aldo-keto reductase family 1 member A1 (sprot)


AK1A1_RAT Aldo-keto reductase family 1 member A1 (sprot)


DHSO_HUMAN Sorbitol dehydrogenase (sprot)


CP4AB_HUMAN Cytochrome P450 4A11 (sprot)


ADRB2_RAT Beta-2 adrenergic receptor (sprot)


A3EZI9_9HEPC Genome polyprotein (Fragment) (trembl)


A3EZJ3_9HEPC Genome polyprotein (Fragment) (trembl)


AGTRB_RAT Type-1 angiotensin II receptor B (sprot)


AGTR2_RAT Type-2 angiotensin II receptor (sprot)


AGTRA_RAT Type-1 angiotensin II receptor A (sprot)


MK09_HUMAN Mitogen-activated protein kinase 9 (sprot)


CCKAR_MOUSE Cholecystokinin receptor type A (sprot)


VGFR3_HUMAN Vascular endothelial growth factor receptor 3 (sprot)


CDK2_HUMAN Cyclin-dependent kinase 2 (sprot)


DAPK3_HUMAN Death-associated protein kinase 3 (sprot)


MK10_HUMAN Mitogen-activated protein kinase 10 (sprot)


KCC2D_HUMAN Calcium/calmodulin-dependent protein kinase type II subunit delta (sprot)


AAK1_HUMAN AP2-associated protein kinase 1 (sprot)


MET_HUMAN Hepatocyte growth factor receptor (sprot)


ST17B_HUMAN Serine/threonine-protein kinase 17B (sprot)


PLK4_HUMAN Serine/threonine-protein kinase PLK4 (sprot)


ST17A_HUMAN Serine/threonine-protein kinase 17A (sprot)


ALK_HUMAN ALK tyrosine kinase receptor (sprot)


BMP2K_HUMAN BMP-2-inducible protein kinase (sprot)


EPHA7_HUMAN Ephrin type-A receptor 7 (sprot)


MKNK2_HUMAN MAP kinase-interacting serine/threonine-protein kinase 2 (sprot)


ULK3_MOUSE Serine/threonine-protein kinase ULK3 (sprot)


UFO_HUMAN Tyrosine-protein kinase receptor UFO (sprot)


TYRO3_HUMAN Tyrosine-protein kinase receptor TYRO3 (sprot)


KC1D_HUMAN Casein kinase I isoform delta (sprot)


TIE1_HUMAN Tyrosine-protein kinase receptor Tie-1 (sprot)


MKNK1_HUMAN MAP kinase-interacting serine/threonine-protein kinase 1 (sprot)


LTK_HUMAN Leukocyte tyrosine kinase receptor (sprot)


MERTK_HUMAN Tyrosine-protein kinase Mer (sprot)


CTRO_HUMAN Citron Rho-interacting kinase (sprot)


COQ8B_HUMAN Atypical kinase COQ8B, mitochondrial (sprot)


MK04_HUMAN Mitogen-activated protein kinase 4 (sprot)


E2AK2_HUMAN Interferon-induced, double-stranded RNA-activated protein kinase (sprot)


KS6A4_HUMAN Ribosomal protein S6 kinase alpha-4 (sprot)


DYRK2_HUMAN Dual specificity tyrosine-phosphorylation-regulated kinase 2 (sprot)


GRK4_HUMAN G protein-coupled receptor kinase 4 (sprot)


HIPK4_HUMAN Homeodomain-interacting protein kinase 4 (sprot)


SRPK3_HUMAN SRSF protein kinase 3 (sprot)


RIPK4_HUMAN Receptor-interacting serine/threonine-protein kinase 4 (sprot)


PI42C_HUMAN Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma (sprot)


LRRK2_HUMAN Leucine-rich repeat serine/threonine-protein kinase 2 (sprot)


SO2B1_HUMAN Solute carrier organic anion transporter family member 2B1 (sprot)


HEMH_HUMAN Ferrochelatase, mitochondrial (sprot)


BRAF_MOUSE Serine/threonine-protein kinase B-raf (sprot)


BUB1_HUMAN Mitotic checkpoint serine/threonine-protein kinase BUB1 (sprot)


ACD11_HUMAN Acyl-CoA dehydrogenase family member 11 (sprot)


DCTP1_HUMAN dCTP pyrophosphatase 1 (sprot)


Erythromycin propionate

A macrolide antibiotic, produced by Streptomyces erythreus. It is the lauryl sulfate salt of the propionic ester of erythromycin. This erythromycin salt acts primarily as a bacteriostatic agent. In sensitive organisms, it inhibits protein synthesis by binding to 50S ribosomal subunits. This binding process inhibits peptidyl transferase activity and interferes with translocation of amino acids during translation and assembly of proteins.


ATP4A_HUMAN Potassium-transporting ATPase alpha chain 1 (sprot)


ATP4B_HUMAN Potassium-transporting ATPase subunit beta (sprot)


GPER1_HUMAN G-protein coupled estrogen receptor 1 (sprot)


ERR1_HUMAN Steroid hormone receptor ERR1 (sprot)


ESR2_MOUSE Estrogen receptor beta (sprot)


Estradiol benzoate

The 17-beta-isomer of estradiol, an aromatized C18 steroid with hydroxyl group at 3-beta- and 17-beta-position. Estradiol-17-beta is the most potent form of mammalian estrogenic steroids


O51E2_HUMAN Olfactory receptor 51E2 (sprot)


MP2K6_HUMAN Dual specificity mitogen-activated protein kinase kinase 6 (sprot)


GSTO1_HUMAN Glutathione S-transferase omega-1 (sprot)


EMBA_MYCTO Probable arabinosyltransferase A (sprot)


EMBB_MYCTO Probable arabinosyltransferase B (sprot)


EMBC_MYCTU Probable arabinosyltransferase C (sprot)


EMBA_MYCTU Probable arabinosyltransferase A (sprot)


INHA_MYCTU Enoyl-[acyl-carrier-protein] reductase [NADH] (sprot)


Ethisterone

17 alpha-Hydroxypregn-4-en-20-yn-3-one. A synthetic steroid hormone with progestational effects.


CAC1G_HUMAN Voltage-dependent T-type calcium channel subunit alpha-1G (sprot)


Ethoxzolamide

A carbonic anhydrase inhibitor used as diuretic and in glaucoma. It may cause hypokalemia.


Ethyl biscoumacetate

A coumarin that is used as an anticoagulant. It has actions similar to those of WARFARIN. (From Martindale, The Extra Pharmacopoeia, 30th ed, p226)


Ethylestrenol

An anabolic steroid with some progestational activity and little androgenic effect.


Etilefrine

A phenylephrine-related beta-1 adrenergic and alpha adrenergic agonist used as a cardiotonic and antihypotensive agent.


Etofylline

etophyllin appeared once in PubMed: Wien Med Wochenschr. 1986 May 15;136(9):213-8 as a combination drug with theophylline (spelt without e, theophllin)


C11B1_HUMAN Cytochrome P450 11B1, mitochondrial (sprot)


C11B2_HUMAN Cytochrome P450 11B2, mitochondrial (sprot)


MRP3_HUMAN ATP-binding cassette sub-family C member 3 (sprot)


GLP1R_HUMAN Glucagon-like peptide 1 receptor (sprot)


GLP1R_RAT Glucagon-like peptide 1 receptor (sprot)


NPCL1_HUMAN NPC1-like intracellular cholesterol transporter 1 (sprot)


NPCL1_RAT NPC1-like intracellular cholesterol transporter 1 (sprot)


Fadrozole

A selective aromatase inhibitor effective in the treatment of estrogen-dependent disease including breast cancer.


C11B2_MOUSE Cytochrome P450 11B2, mitochondrial (sprot)


HS90A_HUMAN Heat shock protein HSP 90-alpha (sprot)


KPCD_HUMAN Protein kinase C delta type (sprot)


KPCE_HUMAN Protein kinase C epsilon type (sprot)


CLK1_HUMAN Dual specificity protein kinase CLK1 (sprot)


KS6A5_HUMAN Ribosomal protein S6 kinase alpha-5 (sprot)


CCL2_HUMAN C-C motif chemokine 2 (sprot)


CDK9_HUMAN Cyclin-dependent kinase 9 (sprot)


PKN2_HUMAN Serine/threonine-protein kinase N2 (sprot)


MELK_HUMAN Maternal embryonic leucine zipper kinase (sprot)


LATS1_HUMAN Serine/threonine-protein kinase LATS1 (sprot)


KAPCA_HUMAN cAMP-dependent protein kinase catalytic subunit alpha (sprot)


KPCD2_HUMAN Serine/threonine-protein kinase D2 (sprot)


KPCD3_HUMAN Serine/threonine-protein kinase D3 (sprot)


ROCK2_RAT Rho-associated protein kinase 2 (sprot)


CDK13_HUMAN Cyclin-dependent kinase 13 (sprot)


PKN3_HUMAN Serine/threonine-protein kinase N3 (sprot)


CDK12_HUMAN Cyclin-dependent kinase 12 (sprot)


ROCK1_HUMAN Rho-associated protein kinase 1 (sprot)


ROCK2_HUMAN Rho-associated protein kinase 2 (sprot)


CFTR_HUMAN Cystic fibrosis transmembrane conductance regulator (sprot)


Fenbufen

an orally active nonsteroidal anti-inflammatory drug with analgesic and antipyretic activity


LUXR_ALIFS Transcriptional activator protein LuxR (sprot)


CASR_BOVIN Extracellular calcium-sensing receptor (sprot)


SC5A8_HUMAN Sodium-coupled monocarboxylate transporter 1 (sprot)


OPRM_MOUSE Mu-type opioid receptor (sprot)


OPRD_MOUSE Delta-type opioid receptor (sprot)


SO1A2_HUMAN Solute carrier organic anion transporter family member 1A2 (sprot)


3BHS1_HUMAN 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1 (sprot)


S5A1_RAT 3-oxo-5-alpha-steroid 4-dehydrogenase 1 (sprot)


S5A2_RAT 3-oxo-5-alpha-steroid 4-dehydrogenase 2 (sprot)


KCND2_RAT Potassium voltage-gated channel subfamily D member 2 (sprot)


Fleroxacin

A broad-spectrum antimicrobial fluoroquinolone. The drug strongly inhibits the DNA-supercoiling activity of DNA GYRASE.


CP51_TRYCC Sterol 14-alpha demethylase (sprot)


HSP82_YEAST ATP-dependent molecular chaperone HSP82 (sprot)


KCNT2_HUMAN Potassium channel subfamily T member 2 (sprot)


TRPM5_HUMAN Transient receptor potential cation channel subfamily M member 5 (sprot)


TEAD4_HUMAN Transcriptional enhancer factor TEF-3 (sprot)


T2R14_HUMAN Taste receptor type 2 member 14 (sprot)


FACE2_HUMAN CAAX prenyl protease 2 (sprot)


CAC1I_HUMAN Voltage-dependent T-type calcium channel subunit alpha-1I (sprot)


ANM1_HUMAN Protein arginine N-methyltransferase 1 (sprot)


KCNC1_RAT Potassium voltage-gated channel subfamily C member 1 (sprot)


KCNQ2_HUMAN Potassium voltage-gated channel subfamily KQT member 2 (sprot)


KCNQ3_HUMAN Potassium voltage-gated channel subfamily KQT member 3 (sprot)


Fluprednisolone

A synthetic glucocorticoid with anti-inflammatory properties.


PA24A_HUMAN Cytosolic phospholipase A2 (sprot)


gamma-Aminobutyric acid

The most common inhibitory neurotransmitter in the central nervous system.


SIR6_HUMAN NAD-dependent protein deacylase sirtuin-6 (sprot)


ADH1B_HUMAN All-trans-retinol dehydrogenase [NAD(+)] ADH1B (sprot)


ADH1G_HUMAN Alcohol dehydrogenase 1C (sprot)


ADH1A_HUMAN Alcohol dehydrogenase 1A (sprot)


DPOL_HCMVA DNA polymerase catalytic subunit (sprot)


MURA1_ENTFA UDP-N-acetylglucosamine 1-carboxyvinyltransferase 1 (sprot)


MURA2_ENTFA UDP-N-acetylglucosamine 1-carboxyvinyltransferase 2 (sprot)


MURA_ECOLI UDP-N-acetylglucosamine 1-carboxyvinyltransferase (sprot)


MURA_PSEAE UDP-N-acetylglucosamine 1-carboxyvinyltransferase (sprot)


D-Fructose

A monosaccharide in sweet fruits and honey that is soluble in water, alcohol, or ether. It is used as a preservative and an intravenous infusion in parenteral feeding.


HYES_HUMAN Bifunctional epoxide hydrolase 2 (sprot)


ACPS_BACSU Holo-[acyl-carrier-protein] synthase (sprot)


SC6A1_RAT Sodium- and chloride-dependent GABA transporter 1 (sprot)


SC6A1_MOUSE Sodium- and chloride-dependent GABA transporter 1 (sprot)


GBRR1_HUMAN Gamma-aminobutyric acid receptor subunit rho-1 (sprot)


S6A11_HUMAN Sodium- and chloride-dependent GABA transporter 3 (sprot)


S6A12_HUMAN Sodium- and chloride-dependent betaine transporter (sprot)


S6A11_MOUSE Sodium- and chloride-dependent GABA transporter 3 (sprot)


S6A13_RAT Sodium- and chloride-dependent GABA transporter 2 (sprot)


S6A13_MOUSE Sodium- and chloride-dependent GABA transporter 2 (sprot)


GPVI_HUMAN Platelet glycoprotein VI (sprot)


S6A13_HUMAN Sodium- and chloride-dependent GABA transporter 2 (sprot)


LAT1_HUMAN Large neutral amino acids transporter small subunit 1 (sprot)


KCNQ5_HUMAN Potassium voltage-gated channel subfamily KQT member 5 (sprot)


CA2D1_MOUSE Voltage-dependent calcium channel subunit alpha-2/delta-1 (sprot)


O77773_PIG Voltage-dependent calcium channel alpha-2 delta subunit (trembl)


CA2D2_HUMAN Voltage-dependent calcium channel subunit alpha-2/delta-2 (sprot)


Alpha D-Galactose

An aldohexose that occurs naturally in the D-form in lactose, cerebrosides, gangliosides, and mucoproteins. Deficiency of galactosyl-1-phosphate uridyltransferase (GALACTOSE-1-PHOSPHATE URIDYL-TRANSFERASE DEFICIENCY DISEASE) causes an error in galactose metabolism called GALACTOSEMIA, resulting in elevations of galactose in the blood.


Flaxedil

A synthetic nondepolarizing blocking drug. The actions of gallamine triethiodide are similar to those of TUBOCURARINE, but this agent blocks the cardiac vagus and may cause sinus tachycardia and, occasionally, hypertension and increased cardiac output. It should be used cautiously in patients at risk from increased heart rate but may be preferred for patients with bradycardia. (From AMA Drug Evaluations Annual, 1992, p198)


Gallopamil

Coronary vasodilator that is an analog of iproveratril (VERAPAMIL) with one more methoxy group on the benzene ring.


gamma-Linolenic acid

An omega-6 fatty acid produced in the body as the delta 6-desaturase metabolite of linoleic acid. It is converted to dihomo-gamma-linolenic acid, a biosynthetic precursor of monoenoic prostaglandins such as PGE1. (From Merck Index, 11th ed)


FFAR1_HUMAN Free fatty acid receptor 1 (sprot)


GRM1_HUMAN Metabotropic glutamate receptor 1 (sprot)


GRM5_HUMAN Metabotropic glutamate receptor 5 (sprot)


SCAF_HHV11 Capsid scaffolding protein (sprot)


PARC_STRPN DNA topoisomerase 4 subunit A (sprot)


PARE_STRPN DNA topoisomerase 4 subunit B (sprot)


PHKG2_HUMAN Phosphorylase b kinase gamma catalytic chain, liver/testis isoform (sprot)


PHKG1_HUMAN Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform (sprot)


CDK7_HUMAN Cyclin-dependent kinase 7 (sprot)


KPCD1_HUMAN Serine/threonine-protein kinase D1 (sprot)


DCLK3_HUMAN Serine/threonine-protein kinase DCLK3 (sprot)


NUAK2_HUMAN NUAK family SNF1-like kinase 2 (sprot)


IRAK3_HUMAN Interleukin-1 receptor-associated kinase 3 (sprot)


PIM3_HUMAN Serine/threonine-protein kinase pim-3 (sprot)


MK06_HUMAN Mitogen-activated protein kinase 6 (sprot)


IRAK4_HUMAN Interleukin-1 receptor-associated kinase 4 (sprot)


CHK2_HUMAN Serine/threonine-protein kinase Chk2 (sprot)


IRAK1_HUMAN Interleukin-1 receptor-associated kinase 1 (sprot)


RIPK3_HUMAN Receptor-interacting serine/threonine-protein kinase 3 (sprot)


ACD10_HUMAN Acyl-CoA dehydrogenase family member 10 (sprot)


Gestodene

synthetic steroid with progestational activity; RN given refers to (17alpha)-isomer


Gestrinone

A non-estrogenic contraceptive which is a weak progestin with strong anti-progesterone properties. It is effective if used once a week orally or can also be used in intravaginal devices.


DPYD_HUMAN Dihydropyrimidine dehydrogenase [NADP(+)] (sprot)


Glafenine

An anthranilic acid derivative with analgesic properties used for the relief of all types of pain.


ABCC9_HUMAN ATP-binding cassette sub-family C member 9 (sprot)


GRIK1_HUMAN Glutamate receptor ionotropic, kainate 1 (sprot)


DHE3_HUMAN Glutamate dehydrogenase 1, mitochondrial (sprot)


DHE4_HUMAN Glutamate dehydrogenase 2, mitochondrial (sprot)


GRIK5_HUMAN Glutamate receptor ionotropic, kainate 5 (sprot)


GRM4_HUMAN Metabotropic glutamate receptor 4 (sprot)


GRIK2_HUMAN Glutamate receptor ionotropic, kainate 2 (sprot)


GRIK3_HUMAN Glutamate receptor ionotropic, kainate 3 (sprot)


GRM7_HUMAN Metabotropic glutamate receptor 7 (sprot)


GRM6_HUMAN Metabotropic glutamate receptor 6 (sprot)


GRM2_HUMAN Metabotropic glutamate receptor 2 (sprot)


EAA1_HUMAN Excitatory amino acid transporter 1 (sprot)


EAA2_HUMAN Excitatory amino acid transporter 2 (sprot)


EAA3_HUMAN Excitatory amino acid transporter 3 (sprot)


GRIK4_HUMAN Glutamate receptor ionotropic, kainate 4 (sprot)


GRM3_HUMAN Metabotropic glutamate receptor 3 (sprot)


GRM8_HUMAN Metabotropic glutamate receptor 8 (sprot)


GRIK2_RAT Glutamate receptor ionotropic, kainate 2 (sprot)


GRIK1_RAT Glutamate receptor ionotropic, kainate 1 (sprot)


GRM4_RAT Metabotropic glutamate receptor 4 (sprot)


GRM6_RAT Metabotropic glutamate receptor 6 (sprot)


GRIK3_RAT Glutamate receptor ionotropic, kainate 3 (sprot)


GRM8_RAT Metabotropic glutamate receptor 8 (sprot)


GRM8_MOUSE Metabotropic glutamate receptor 8 (sprot)


GRM1_RAT Metabotropic glutamate receptor 1 (sprot)


GRM2_RAT Metabotropic glutamate receptor 2 (sprot)


GRM3_RAT Metabotropic glutamate receptor 3 (sprot)


EAA4_RAT Excitatory amino acid transporter 4 (sprot)


Q9Z1J7_RAT Amino acid transporter (trembl)


GSTK1_HUMAN Glutathione S-transferase kappa 1 (sprot)


NLRP3_HUMAN NACHT, LRR and PYD domains-containing protein 3 (sprot)


NLRP3_MOUSE NACHT, LRR and PYD domains-containing protein 3 (sprot)


ABCC8_RAT ATP-binding cassette sub-family C member 8 (sprot)


TRPM4_RAT Transient receptor potential cation channel subfamily M member 4 (sprot)


SC6A9_HUMAN Sodium- and chloride-dependent glycine transporter 1 (sprot)


Glycyrrhizic acid

A widely used anti-inflammatory agent isolated from the licorice root. It is metabolized to GLYCYRRHETINIC ACID, which inhibits 11-BETA-HYDROXYSTEROID DEHYDROGENASES and other enzymes involved in the metabolism of CORTICOSTEROIDS. Therefore, glycyrrhizic acid, which is the main and sweet component of licorice, has been investigated for its ability to cause hypermineralocorticoidism with sodium retention and potassium loss, edema, increased blood pressure, as well as depression of the renin-angiotensin-aldosterone system.


HMGB1_HUMAN High mobility group protein B1 (sprot)


Gossypol

A dimeric sesquiterpene found in cottonseed (GOSSYPIUM). The (-) isomer is active as a male contraceptive (CONTRACEPTIVE AGENTS, MALE) whereas toxic symptoms are associated with the (+) isomer.


ASPH_HUMAN Aspartyl/asparaginyl beta-hydroxylase (sprot)


B2CL1_HUMAN Bcl-2-like protein 1 (sprot)


MDHM_PIG Malate dehydrogenase, mitochondrial (sprot)


Q0PJ46_PLAFA L-lactate dehydrogenase (trembl)


Q6VVP7_PLAFA L-lactate dehydrogenase (trembl)


MDHC_PIG Malate dehydrogenase, cytoplasmic (sprot)


B2CL2_HUMAN Bcl-2-like protein 2 (sprot)


KIF11_HUMAN Kinesin-like protein KIF11 (sprot)


3MG_HUMAN DNA-3-methyladenine glycosylase (sprot)


LDHB_HUMAN L-lactate dehydrogenase B chain (sprot)


F2SG63_TRIRC Tubulin alpha chain (trembl)


F2SZ02_TRIRC Tubulin alpha chain (trembl)


F2SZD3_TRIRC Tubulin beta chain (trembl)


KCNA2_HUMAN Potassium voltage-gated channel subfamily A member 2 (sprot)


KCNA6_HUMAN Potassium voltage-gated channel subfamily A member 6 (sprot)


KCNA4_HUMAN Potassium voltage-gated channel subfamily A member 4 (sprot)


KCNC1_HUMAN Potassium voltage-gated channel subfamily C member 1 (sprot)


KCNQ1_HUMAN Potassium voltage-gated channel subfamily KQT member 1 (sprot)


KCNC4_HUMAN Potassium voltage-gated channel subfamily C member 4 (sprot)


KCNC3_HUMAN Potassium voltage-gated channel subfamily C member 3 (sprot)


KCNB1_HUMAN Potassium voltage-gated channel subfamily B member 1 (sprot)


KCA10_HUMAN Potassium voltage-gated channel subfamily A member 10 (sprot)


KCNV1_HUMAN Potassium voltage-gated channel subfamily V member 1 (sprot)


KCNH5_HUMAN Potassium voltage-gated channel subfamily H member 5 (sprot)


KCNG3_HUMAN Potassium voltage-gated channel subfamily G member 3 (sprot)


KCNG4_HUMAN Potassium voltage-gated channel subfamily G member 4 (sprot)


KCNV2_HUMAN Potassium voltage-gated channel subfamily V member 2 (sprot)


KCNB2_HUMAN Potassium voltage-gated channel subfamily B member 2 (sprot)


KCNS1_HUMAN Potassium voltage-gated channel subfamily S member 1 (sprot)


KCNH8_HUMAN Potassium voltage-gated channel subfamily H member 8 (sprot)


KCNC2_HUMAN Potassium voltage-gated channel subfamily C member 2 (sprot)


KCNS3_HUMAN Potassium voltage-gated channel subfamily S member 3 (sprot)


KCNH6_HUMAN Potassium voltage-gated channel subfamily H member 6 (sprot)


KCNF1_HUMAN Potassium voltage-gated channel subfamily F member 1 (sprot)


KCNH7_HUMAN Potassium voltage-gated channel subfamily H member 7 (sprot)


KCND1_HUMAN Potassium voltage-gated channel subfamily D member 1 (sprot)


KCND2_HUMAN Potassium voltage-gated channel subfamily D member 2 (sprot)


KCNG1_HUMAN Potassium voltage-gated channel subfamily G member 1 (sprot)


KCNG2_HUMAN Potassium voltage-gated channel subfamily G member 2 (sprot)


KCNH3_HUMAN Potassium voltage-gated channel subfamily H member 3 (sprot)


KCNS2_HUMAN Potassium voltage-gated channel subfamily S member 2 (sprot)


KCNH4_HUMAN Potassium voltage-gated channel subfamily H member 4 (sprot)


Q4U254_9ENTO Genome polyprotein (Fragment) (trembl)


5HT2A_PIG 5-hydroxytryptamine receptor 2A (sprot)


VACHT_RAT Vesicular acetylcholine transporter (sprot)


AP2S1_RAT AP-2 complex subunit sigma (sprot)


ZN664_CAVPO Zinc finger protein 664 (sprot)


DPP4_HUMAN Dipeptidyl peptidase 4 (sprot)


GSK3B_HUMAN Glycogen synthase kinase-3 beta (sprot)


KDM1A_HUMAN Lysine-specific histone demethylase 1A (sprot)


Q54618_STREE Penicillin binding protein 2B (trembl)


Q75Y37_STREE Serine-type D-Ala-D-Ala carboxypeptidase (trembl)


Q75Y54_STREE Penicillin-binding protein 2X (trembl)


Q75YD8_STREE PBP1A family penicillin-binding protein (trembl)


Q75YK0_STREE Penicillin-binding protein (trembl)


Q9RET4_STREE Penicillin-binding protein 1A (trembl)


DLD_ECOLI Quinone-dependent D-lactate dehydrogenase (sprot)


FABI_ECOLI Enoyl-[acyl-carrier-protein] reductase [NADH] FabI (sprot)


MIF_HUMAN Macrophage migration inhibitory factor (sprot)


NAPEP_HUMAN N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D (sprot)


NAPEP_MOUSE N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D (sprot)


Hexafluronium

curarimimetic agent for use with succinylcholine; muscle relaxant; structure; RN given refers to parent cpd


Hexamethonium

A nicotinic cholinergic antagonist often referred to as the prototypical ganglionic blocker. It is poorly absorbed from the gastrointestinal tract and does not cross the blood-brain barrier. It has been used for a variety of therapeutic purposes including hypertension but, like the other ganglionic blockers, it has been replaced by more specific drugs for most purposes, although it is widely used a research tool.


ACHB_TETCF Acetylcholine receptor subunit beta (sprot)


ACHG_TETCF Acetylcholine receptor subunit gamma (sprot)


ACHA6_HUMAN Neuronal acetylcholine receptor subunit alpha-6 (sprot)


Hexestrol

A synthetic estrogen that has been used as a hormonal antineoplastic agent.


Hexobarbital

A barbiturate that is effective as a hypnotic and sedative.


Hexobendine

A potent vasoactive agent that dilates cerebral and coronary arteries, but slightly constricts femoral arteries, without any effects on heart rate, blood pressure or cardiac output.


HRH3_MOUSE Histamine H3 receptor (sprot)


HRH3_CAVPO Histamine H3 receptor (sprot)


Q91ZY3_CAVPO Histamine H4 receptor (trembl)


Hycanthone

Potentially toxic, but effective antischistosomal agent, it is a metabolite of LUCANTHONE.


APEX1_HUMAN DNA-(apurinic or apyrimidinic site) endonuclease (sprot)


DNM3B_HUMAN DNA (cytosine-5)-methyltransferase 3B (sprot)


GCR_MOUSE Glucocorticoid receptor (sprot)


HBA_HUMAN Hemoglobin subunit alpha (sprot)


Hidroxiestilbamidina

minor descriptor (63-86); on-line & INDEX MEDICUS search STILBAMIDINES (66-86); RN given refers to parent cpd


Hymecromone

A coumarin derivative possessing properties as a spasmolytic, choleretic and light-protective agent. It is also used in ANALYTICAL CHEMISTRY TECHNIQUES for the determination of NITRIC ACID.


GGPPS_HUMAN Geranylgeranyl pyrophosphate synthase (sprot)


DHRS9_RAT Dehydrogenase/reductase SDR family member 9 (sprot)


DGAT1_HUMAN Diacylglycerol O-acyltransferase 1 (sprot)


T1VXA1_SCHMA NAD-dependent protein deacetylase (trembl)


Ifenprodil

NMDA receptor antagonist; RN given refers to parent cpd without isomeric designation; structure


MK08_HUMAN Mitogen-activated protein kinase 8 (sprot)


CLK4_HUMAN Dual specificity protein kinase CLK4 (sprot)


CSK22_HUMAN Casein kinase II subunit alpha' (sprot)


CDK19_HUMAN Cyclin-dependent kinase 19 (sprot)


ABL1_MOUSE Tyrosine-protein kinase ABL1 (sprot)


PGFRB_RAT Platelet-derived growth factor receptor beta (sprot)


DDX3X_HUMAN ATP-dependent RNA helicase DDX3X (sprot)


8ODP_HUMAN Oxidized purine nucleoside triphosphate hydrolase (sprot)


Q8MTZ4_9TRYP H(+)-exporting diphosphatase (trembl)


Indalpine

selective 5-hydroxytryptamine uptake inhibitor; RN given refers to parent cpd


INDISETRON

an anti-emetic agent, indisetron hydrochloride was developed in Japan


DHRS9_HUMAN Dehydrogenase/reductase SDR family member 9 (sprot)


Indoramin

An alpha-1 adrenergic antagonist that is commonly used as an antihypertensive agent.


NOS2_MOUSE Nitric oxide synthase, inducible (sprot)


AK1C4_HUMAN Aldo-keto reductase family 1 member C4 (sprot)


Indoprofen

A drug that has analgesic and anti-inflammatory properties. Following reports of adverse reactions including reports of carcinogenicity in animal studies it was withdrawn from the market worldwide. (From Martindale, The Extra Pharmacopoeia, 30th ed, p21)


LUCI_PHOPY Luciferin 4-monooxygenase (sprot)


Iprindole

A tricyclic antidepressant that has actions and uses similar to those of AMITRIPTYLINE, but has only weak antimuscarinic and sedative effects. (From Martindale, The Extra Pharmacopoeia, 30th ed, p257)


Isoetharine

Adrenergic beta-2 agonist used as bronchodilator for emphysema, bronchitis and asthma.


Diisopropyl fluorophosphate

A di-isopropyl-fluorophosphate which is an irreversible cholinesterase inhibitor used to investigate the NERVOUS SYSTEM.


DYR_MYCTU Dihydrofolate reductase (sprot)


ADRB2_MESAU Beta-2 adrenergic receptor (sprot)


T2R38_HUMAN Taste receptor type 2 member 38 (sprot)


T2R39_HUMAN Taste receptor type 2 member 39 (sprot)


T2R40_HUMAN Taste receptor type 2 member 40 (sprot)


T2R41_HUMAN Taste receptor type 2 member 41 (sprot)


T2R43_HUMAN Taste receptor type 2 member 43 (sprot)


T2R31_HUMAN Taste receptor type 2 member 31 (sprot)


T2R45_HUMAN Taste receptor type 2 member 45 (sprot)


T2R30_HUMAN Taste receptor type 2 member 30 (sprot)


T2R19_HUMAN Taste receptor type 2 member 19 (sprot)


T2R20_HUMAN Taste receptor type 2 member 20 (sprot)


T2R50_HUMAN Taste receptor type 2 member 50 (sprot)


T2R60_HUMAN Taste receptor type 2 member 60 (sprot)


T2R42_HUMAN Taste receptor type 2 member 42 (sprot)


T2R16_HUMAN Taste receptor type 2 member 16 (sprot)


T2R13_HUMAN Taste receptor type 2 member 13 (sprot)


T2R10_HUMAN Taste receptor type 2 member 10 (sprot)


TA2R9_HUMAN Taste receptor type 2 member 9 (sprot)


TA2R8_HUMAN Taste receptor type 2 member 8 (sprot)


TA2R7_HUMAN Taste receptor type 2 member 7 (sprot)


TA2R5_HUMAN Taste receptor type 2 member 5 (sprot)


TA2R4_HUMAN Taste receptor type 2 member 4 (sprot)


TA2R3_HUMAN Taste receptor type 2 member 3 (sprot)


TA2R1_HUMAN Taste receptor type 2 member 1 (sprot)


GCYA2_HUMAN Guanylate cyclase soluble subunit alpha-2 (sprot)


GCYA1_HUMAN Guanylate cyclase soluble subunit alpha-1 (sprot)


GCYB2_HUMAN Guanylate cyclase soluble subunit beta-2 (sprot)


GCYB1_HUMAN Guanylate cyclase soluble subunit beta-1 (sprot)


ADH4_HUMAN All-trans-retinol dehydrogenase [NAD(+)] ADH4 (sprot)


RDH5_HUMAN Retinol dehydrogenase 5 (sprot)


H17B6_HUMAN 17-beta-hydroxysteroid dehydrogenase type 6 (sprot)


RABP1_CHICK Cellular retinoic acid-binding protein 1 (sprot)


CAC1C_MOUSE Voltage-dependent L-type calcium channel subunit alpha-1C (sprot)


FABH_ECOLI Beta-ketoacyl-[acyl-carrier-protein] synthase III (sprot)


CXB2_HUMAN Gap junction beta-2 protein (sprot)


CXA1_HUMAN Gap junction alpha-1 protein (sprot)


Bekanamycin

kanendomycin is the sulfate of bekanamycin; RN given refers to parent cpd; structure


C3TDZ2_ECOLX 3-oxoacyl-[acyl-carrier-protein] synthase 3 (trembl)


VMAT1_HUMAN Chromaffin granule amine transporter (sprot)


5HT1B_MOUSE 5-hydroxytryptamine receptor 1B (sprot)


VMAT2_MOUSE Synaptic vesicular amine transporter (sprot)


SGMR1_MOUSE Sigma non-opioid intracellular receptor 1 (sprot)


OPRK_MOUSE Kappa-type opioid receptor (sprot)


PAK1_HUMAN Serine/threonine-protein kinase PAK 1 (sprot)


GNRHR_RAT Gonadotropin-releasing hormone receptor (sprot)


CP24A_HUMAN 1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial (sprot)


CP21A_HUMAN Steroid 21-hydroxylase (sprot)


C11B1_BOVIN Cytochrome P450 11B1, mitochondrial (sprot)


CP11A_RAT Cholesterol side-chain cleavage enzyme, mitochondrial (sprot)


CP24A_RAT 1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial (sprot)


CP51A_RAT Lanosterol 14-alpha demethylase (sprot)


CP17A_RAT Steroid 17-alpha-hydroxylase/17,20 lyase (sprot)


CP27B_MOUSE 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial (sprot)


STE24_YEAST CAAX prenyl protease 1 (sprot)


SCNAA_RAT Sodium channel protein type 10 subunit alpha (sprot)


SSR2_HUMAN Somatostatin receptor type 2 (sprot)


SSR3_HUMAN Somatostatin receptor type 3 (sprot)


SSR2_MOUSE Somatostatin receptor type 2 (sprot)


SSR3_MOUSE Somatostatin receptor type 3 (sprot)


SSR5_RAT Somatostatin receptor type 5 (sprot)


SSR1_HUMAN Somatostatin receptor type 1 (sprot)


SSR2_RAT Somatostatin receptor type 2 (sprot)


SSR3_RAT Somatostatin receptor type 3 (sprot)


PHOP1_HUMAN Phosphoethanolamine/phosphocholine phosphatase (sprot)


TAU_HUMAN Microtubule-associated protein tau (sprot)


DDAH1_HUMAN N(G),N(G)-dimethylarginine dimethylaminohydrolase 1 (sprot)


ENASE_HUMAN Cytosolic endo-beta-N-acetylglucosaminidase (sprot)


MP2K7_HUMAN Dual specificity mitogen-activated protein kinase kinase 7 (sprot)


P3C2B_HUMAN Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta (sprot)


P3C2G_HUMAN Phosphatidylinositol 3-kinase C2 domain-containing subunit gamma (sprot)


GPC6A_HUMAN G-protein coupled receptor family C group 6 member A (sprot)


S2512_HUMAN Electrogenic aspartate/glutamate antiporter SLC25A12, mitochondrial (sprot)


AATC_HUMAN Aspartate aminotransferase, cytoplasmic (sprot)


ASNS_HUMAN Asparagine synthetase [glutamine-hydrolyzing] (sprot)


ASSY_HUMAN Argininosuccinate synthase (sprot)


AATM_HUMAN Aspartate aminotransferase, mitochondrial (sprot)


SYDC_HUMAN Aspartate--tRNA ligase, cytoplasmic (sprot)


S2513_HUMAN Electrogenic aspartate/glutamate antiporter SLC25A13, mitochondrial (sprot)


GLT_PYRHO Glutamate transporter homolog (sprot)


DAPA_ECOLI 4-hydroxy-tetrahydrodipicolinate synthase (sprot)


PYRD_MOUSE Dihydroorotate dehydrogenase (quinone), mitochondrial (sprot)


Levallorphan

An opioid antagonist with properties similar to those of NALOXONE; in addition it also possesses some agonist properties. It should be used cautiously; levallorphan reverses severe opioid-induced respiratory depression but may exacerbate respiratory depression such as that induced by alcohol or other non-opioid central depressants. (From Martindale, The Extra Pharmacopoeia, 30th ed, p683)


ACH6_CAEEL Acetylcholine receptor subunit alpha-type unc-63 (sprot)


O96760_ASCSU Nicotinic acetylcholine receptor alpha subunit (Fragment) (trembl)


PPBT_BOVIN Alkaline phosphatase, tissue-nonspecific isozyme (sprot)


PPBI_HUMAN Intestinal-type alkaline phosphatase (sprot)


SV2A_RAT Synaptic vesicle glycoprotein 2A (sprot)


SV2A_HUMAN Synaptic vesicle glycoprotein 2A (sprot)


NTR2_HUMAN Neurotensin receptor type 2 (sprot)


NTR2_RAT Neurotensin receptor type 2 (sprot)


NTR2_MOUSE Neurotensin receptor type 2 (sprot)


KCNJ8_HUMAN ATP-sensitive inward rectifier potassium channel 8 (sprot)


TNNC1_HUMAN Troponin C, slow skeletal and cardiac muscles (sprot)


Lidoflazine

Coronary vasodilator with some antiarrhythmic action.


GBRB_MUSDO Gamma-aminobutyric acid receptor subunit beta (sprot)


H9U2V9_TETUR GABA-gated chloride channel 1 (trembl)


H9U2W0_TETUR GABA-gated chloride channel 2 (Fragment) (trembl)


H9U2W1_TETUR GABA-gated chloride channel 3 (Fragment) (trembl)


E0V9W2_PEDHC Gaba-gated chloride channel, putative (trembl)


E0VY07_PEDHC Gaba-gated chloride channel, putative (trembl)


E0W492_PEDHC Gaba-gated chloride channel, putative (trembl)


SDHA_HUMAN Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial (sprot)


PCNA_HUMAN Proliferating cell nuclear antigen (sprot)


FACE1_MOUSE CAAX prenyl protease 1 homolog (sprot)


S6A15_HUMAN Sodium-dependent neutral amino acid transporter B(0)AT2 (sprot)


AGTR2_HUMAN Type-2 angiotensin II receptor (sprot)


AGTR1_CAVPO Type-1 angiotensin II receptor (sprot)


HCAR3_HUMAN Hydroxycarboxylic acid receptor 3 (sprot)


HMDH_MOUSE 3-hydroxy-3-methylglutaryl-coenzyme A reductase (sprot)


Q95214_RABIT Acyl-CoA:cholesterol acyltransferase (Fragment) (trembl)


KCNT1_HUMAN Potassium channel subfamily T member 1 (sprot)


Loxiglumide

cholecystokinin receptor antagonist; RN refers to (+-)-isomer


Lucanthone

One of the SCHISTOSOMICIDES, it has been replaced largely by HYCANTHONE and more recently PRAZIQUANTEL. (From Martindale The Extrapharmacopoeia, 30th ed., p46)


DHPS_ECOLI Dihydropteroate synthase (sprot)


A2PZ98_9NEOP Carboxylic ester hydrolase (trembl)


Q39829_SOYBN Lipoxygenase (Fragment) (trembl)


CCR5_MOUSE C-C chemokine receptor type 5 (sprot)


CCR5_MACMU C-C chemokine receptor type 5 (sprot)


IGF1R_HUMAN Insulin-like growth factor 1 receptor (sprot)


LT4R1_HUMAN Leukotriene B4 receptor 1 (sprot)


LOX1_SOYBN Seed linoleate 13S-lipoxygenase-1 (sprot)


LOX5_MOUSE Polyunsaturated fatty acid 5-lipoxygenase (sprot)


HPL_SOLLC Fatty acid hydroperoxide lyase, chloroplastic (sprot)


Q9BJF5_TOXGO Calmodulin-domain protein kinase 1 (trembl)


ACHB3_HUMAN Neuronal acetylcholine receptor subunit beta-3 (sprot)


AMDINOCILLIN

An amidinopenicillanic acid derivative with broad spectrum antibacterial action.


NR1I3_MOUSE Nuclear receptor subfamily 1 group I member 3 (sprot)


Medazepam

A benzodiazepine derivative used in the treatment of anxiety. It has sedative, muscle relaxant, and anticonvulsant properties. One of its metabolites is DIAZEPAM and one of its excretion products is OXAZEPAM.


P90584_PLAFA MO15-related protein kinase Pfmrk (trembl)


Meglutol

An antilipemic agent which lowers cholesterol, triglycerides, serum beta-lipoproteins and phospholipids. It acts by interfering with the enzymatic steps involved in the conversion of acetate to hydroxymethylglutaryl coenzyme A as well as inhibiting the activity of HYDROXYMETHYLGLUTARYL COA REDUCTASES which is the rate limiting enzyme in the biosynthesis of cholesterol.


RORA_HUMAN Nuclear receptor ROR-alpha (sprot)


MTR1C_XENLA Melatonin receptor type 1C (sprot)


LAT1_RAT Large neutral amino acids transporter small subunit 1 (sprot)


MPIP2_HUMAN M-phase inducer phosphatase 2 (sprot)


MPIP3_HUMAN M-phase inducer phosphatase 3 (sprot)


UCHL3_HUMAN Ubiquitin carboxyl-terminal hydrolase isozyme L3 (sprot)


MPIP1_HUMAN M-phase inducer phosphatase 1 (sprot)


DUS6_RAT Dual specificity protein phosphatase 6 (sprot)


DUS1_MOUSE Dual specificity protein phosphatase 1 (sprot)


Menadione bisulfite

A synthetic naphthoquinone without the isoprenoid side chain and biological activity, but can be converted to active vitamin K2, menaquinone, after alkylation in vivo.


MALT1_HUMAN Mucosa-associated lymphoid tissue lymphoma translocation protein 1 (sprot)


Meproscillarin

semi-synthetic derivative of proscillaridin of Scilla (Liliaceae); structure in Negwer, 5th ed, #6625; RN given refers to (3beta)-isomer


Q389T8_TRYB2 Trypanothione reductase (trembl)


TNFA_HUMAN Tumor necrosis factor (sprot)


HAOX1_MOUSE 2-Hydroxyacid oxidase 1 (sprot)


Metergoline

A dopamine agonist and serotonin antagonist. It has been used similarly to BROMOCRIPTINE as a dopamine agonist and also for MIGRAINE DISORDERS therapy.


AAKB1_HUMAN 5'-AMP-activated protein kinase subunit beta-1 (sprot)


NDUA4_HUMAN Cytochrome c oxidase subunit NDUFA4 (sprot)


ACPM_HUMAN Acyl carrier protein, mitochondrial (sprot)


NDUA1_HUMAN NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 (sprot)


NDUS4_HUMAN NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial (sprot)


NDUB5_HUMAN NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial (sprot)


NDUB3_HUMAN NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 (sprot)


NDUC1_HUMAN NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial (sprot)


NDUA2_HUMAN NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 (sprot)


NDUS5_HUMAN NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 (sprot)


NDUS6_HUMAN NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial (sprot)


NDUB1_HUMAN NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 (sprot)


NDUS3_HUMAN NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial (sprot)


NDUB6_HUMAN NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 (sprot)


NDUA3_HUMAN NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 (sprot)


NDUB4_HUMAN NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 (sprot)


NDUB8_HUMAN NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial (sprot)


NDUB2_HUMAN NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial (sprot)


NDUA7_HUMAN NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 (sprot)


NDUC2_HUMAN NADH dehydrogenase [ubiquinone] 1 subunit C2 (sprot)


NDUBA_HUMAN NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 (sprot)


NU1M_HUMAN NADH-ubiquinone oxidoreductase chain 1 (sprot)


NU2M_HUMAN NADH-ubiquinone oxidoreductase chain 2 (sprot)


NU3M_HUMAN NADH-ubiquinone oxidoreductase chain 3 (sprot)


NU4LM_HUMAN NADH-ubiquinone oxidoreductase chain 4L (sprot)


NU4M_HUMAN NADH-ubiquinone oxidoreductase chain 4 (sprot)


NU5M_HUMAN NADH-ubiquinone oxidoreductase chain 5 (sprot)


NU6M_HUMAN NADH-ubiquinone oxidoreductase chain 6 (sprot)


NDUB7_HUMAN NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 (sprot)


NDUA8_HUMAN NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 (sprot)


NDUV3_HUMAN NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial (sprot)


NDUA6_HUMAN NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 (sprot)


NDUA5_HUMAN NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 (sprot)


NDUAB_HUMAN NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 (sprot)


NDUF2_HUMAN NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 2 (sprot)


NDUF3_HUMAN NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 3 (sprot)


NUA4L_HUMAN NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2 (sprot)


NDUBB_HUMAN NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial (sprot)


NDUF4_HUMAN NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 4 (sprot)


NDUAD_HUMAN NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 (sprot)


NDUAC_HUMAN NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 (sprot)


CIA30_HUMAN Complex I intermediate-associated protein 30, mitochondrial (sprot)


NDUB9_HUMAN NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 (sprot)


NDUS8_HUMAN NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial (sprot)


NDUS7_HUMAN NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial (sprot)


NDUS2_HUMAN NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial (sprot)


NDUAA_HUMAN NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial (sprot)


NDUV2_HUMAN NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial (sprot)


NDUS1_HUMAN NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial (sprot)


NDUV1_HUMAN NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial (sprot)


NDUA9_HUMAN NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial (sprot)


RAD52_HUMAN DNA repair protein RAD52 homolog (sprot)


ACH10_HUMAN Neuronal acetylcholine receptor subunit alpha-10 (sprot)


VMAT2_RAT Synaptic vesicular amine transporter (sprot)


Methaqualone

A quinazoline derivative with hypnotic and sedative properties. It has been withdrawn from the market in many countries because of problems with abuse. (From Martindale, The Extra Pharmacopoeia, 30th ed, p604)


PBP_STAAU Beta-lactam-inducible penicillin-binding protein (sprot)


NADE_ECOLI NH(3)-dependent NAD(+) synthetase (sprot)


DOPO_BOVIN Dopamine beta-hydroxylase (sprot)


FOLR2_HUMAN Folate receptor beta (sprot)


PCFT_HUMAN Proton-coupled folate transporter (sprot)


DRTS_LEIMA Bifunctional dihydrofolate reductase-thymidylate synthase (sprot)


C3SWJ7_ECOLX Thymidylate synthase (trembl)


PTR1_LEIMA Pteridine reductase 1 (sprot)


DYR_STAAU Dihydrofolate reductase (sprot)


Q81R22_BACAN Dihydrofolate reductase (trembl)


DYR_ENTFC Dihydrofolate reductase (sprot)


S19A1_HUMAN Reduced folate transporter (sprot)


FOLR1_HUMAN Folate receptor alpha (sprot)


PUR9_HUMAN Bifunctional purine biosynthesis protein ATIC (sprot)


Methoxyflurane

An inhalation anesthetic. Currently, methoxyflurane is rarely used for surgical, obstetric, or dental anesthesia. If so employed, it should be administered with NITROUS OXIDE to achieve a relatively light level of anesthesia, and a neuromuscular blocking agent given concurrently to obtain the desired degree of muscular relaxation. (From AMA Drug Evaluations Annual, 1994, p180)


GSHR_PLAF7 Glutathione reductase (sprot)


Methylparaben

used as a preservative in cosmetics but potentiates UV-induced damage of skin; RN given refers to parent cpd


Methysergide

An ergot derivative that is a congener of LYSERGIC ACID DIETHYLAMIDE. It antagonizes the effects of serotonin in blood vessels and gastrointestinal smooth muscle, but has few of the properties of other ergot alkaloids. Methysergide is used prophylactically in migraine and other vascular headaches and to antagonize serotonin in the carcinoid syndrome.


Metiazinic acid

phenothiazine which acts as an anti-inflammatory agent; minor descriptor (75-86); on line & INDEX MEDICUS search PHENOTHIAZINES (75-86)


5HT3B_MOUSE 5-hydroxytryptamine receptor 3B (sprot)


C4LW95_ENTHI Thioredoxin reductase (trembl)


C11B1_RAT Cytochrome P450 11B1, mitochondrial (sprot)


TY3H_HUMAN Tyrosine 3-monooxygenase (sprot)


SCN9A_MOUSE Sodium channel protein type 9 subunit alpha (sprot)


SCN1A_MOUSE Sodium channel protein type 1 subunit alpha (sprot)


CNR2_HUMAN Cannabinoid receptor 2 (sprot)


IL1R1_HUMAN Interleukin-1 receptor type 1 (sprot)


PTGDS_HUMAN Prostaglandin-H2 D-isomerase (sprot)


Q9NG02_APIME G-protein coupled receptor (trembl)


CAC1E_RAT Voltage-dependent R-type calcium channel subunit alpha-1E (sprot)


CAC1A_RAT Voltage-dependent P/Q-type calcium channel subunit alpha-1A (sprot)


SCN4A_RAT Sodium channel protein type 4 subunit alpha (sprot)


O13428_CANAX 1,3-beta-glucan synthase (trembl)


GDE_RABIT Glycogen debranching enzyme (sprot)


LPH_HUMAN Lactase/phlorizin hydrolase (sprot)


GBA2_MOUSE Non-lysosomal glucosylceramidase (sprot)


GBA2_HUMAN Non-lysosomal glucosylceramidase (sprot)


GDE_HUMAN Glycogen debranching enzyme (sprot)


LYAG_MOUSE Lysosomal alpha-glucosidase (sprot)


Q9LGC6_ORYSJ Putative alpha-glucosidase (trembl)


O70282_RAT Trehalase (Fragment) (trembl)


CEGT_MOUSE Ceramide glucosyltransferase (sprot)


PDE5A_BOVIN cGMP-specific 3',5'-cyclic phosphodiesterase (sprot)


PDE4A_CAVPO cAMP-specific 3',5'-cyclic phosphodiesterase 4A (Fragment) (sprot)


AKT1_HUMAN RAC-alpha serine/threonine-protein kinase (sprot)


L-mimosine

3-Hydroxy-4-oxo-1(4H)-pyridinealanine. An antineoplastic alanine-substituted pyridine derivative isolated from Leucena glauca.


GLYC_HUMAN Serine hydroxymethyltransferase, cytosolic (sprot)


RIR1_HHV11 Ribonucleoside-diphosphate reductase large subunit (sprot)


Minaprine

Agr 1240 refers to di-HCl; short-acting type A MAO inhibitor (MAOI) of mild potency; structure


RS4_CHLPN 30S ribosomal protein S4 (sprot)


RS9_CHLPN 30S ribosomal protein S9 (sprot)


KCNJ1_HUMAN ATP-sensitive inward rectifier potassium channel 1 (sprot)


ADX_HUMAN Adrenodoxin, mitochondrial (sprot)


ROS1_HUMAN Proto-oncogene tyrosine-protein kinase ROS (sprot)


DYR1A_RAT Dual specificity tyrosine-phosphorylation-regulated kinase 1A (sprot)


TADBP_HUMAN TAR DNA-binding protein 43 (sprot)


AOFA_BOVIN Amine oxidase [flavin-containing] A (sprot)


Mofezolac

Cyclooxygenase 1 inhibitor; ; RN from Toxlit


CLTR2_HUMAN Cysteinyl leukotriene receptor 2 (sprot)


GPR17_MOUSE Uracil nucleotide/cysteinyl leukotriene receptor (sprot)


OPRM_BOVIN Mu-type opioid receptor (sprot)


Q98UH1_DANRE Mu-type opioid receptor (trembl)


B3DH72_DANRE Opioid receptor, delta 1b (trembl)


O57585_DANRE Opioid receptor homologue (trembl)


Latamoxef

Broad- spectrum beta-lactam antibiotic similar in structure to the CEPHALOSPORINS except for the substitution of an oxaazabicyclo moiety for the thiaazabicyclo moiety of certain CEPHALOSPORINS. It has been proposed especially for the meningitides because it passes the blood-brain barrier and for anaerobic infections.


SYI_ECOLI Isoleucine--tRNA ligase (sprot)


SYIC_HUMAN Isoleucine--tRNA ligase, cytoplasmic (sprot)


SYI1_STAAU Isoleucine--tRNA ligase (sprot)


SYI_STRP1 Isoleucine--tRNA ligase (sprot)


SYI_THET8 Isoleucine--tRNA ligase (sprot)


Q8I5G6_PLAF7 Isoleucine--tRNA ligase, putative (trembl)


IMDH1_HUMAN Inosine-5'-monophosphate dehydrogenase 1 (sprot)


IMDH2_HUMAN Inosine-5'-monophosphate dehydrogenase 2 (sprot)


IMDH_CRYNJ Inosine-5'-monophosphate dehydrogenase (sprot)


CNR2_MOUSE Cannabinoid receptor 2 (sprot)


ST14_HUMAN Suppressor of tumorigenicity 14 protein (sprot)


C1R_HUMAN Complement C1r subcomponent (sprot)


C1S_HUMAN Complement C1s subcomponent (sprot)


TRYB1_HUMAN Tryptase alpha/beta-1 (sprot)


FA12_HUMAN Coagulation factor XII (sprot)


CRTN_STAAE 4,4'-diapophytoene desaturase (4,4'-diaponeurosporene-forming) (sprot)


Nalorphine

A narcotic antagonist with some agonist properties. It is an antagonist at mu opioid receptors and an agonist at kappa opioid receptors. Given alone it produces a broad spectrum of unpleasant effects and it is considered to be clinically obsolete.


Nemonapride

an atypical antipsychotic approved in Japan for the treatment of schizophrenia


Neomycin

A component of NEOMYCIN that is produced by Streptomyces fradiae. On hydrolysis it yields neamine and neobiosamine B. (From Merck Index, 11th ed)


RS12_ECOLI 30S ribosomal protein S12 (sprot)


SYFA_ECOLI Phenylalanine--tRNA ligase alpha subunit (sprot)


SYFB_ECOLI Phenylalanine--tRNA ligase beta subunit (sprot)


LRAT_HUMAN Lecithin retinol acyltransferase (sprot)


CASR_RAT Extracellular calcium-sensing receptor (sprot)


NNMT_HUMAN Nicotinamide N-methyltransferase (sprot)


NADC_HUMAN Nicotinate-nucleotide pyrophosphorylase [carboxylating] (sprot)


SIR1_HUMAN NAD-dependent protein deacetylase sirtuin-1 (sprot)


SIR2_HUMAN NAD-dependent protein deacetylase sirtuin-2 (sprot)


HST2_YEAST NAD-dependent protein deacetylase HST2 (sprot)


SIR3_HUMAN NAD-dependent protein deacetylase sirtuin-3, mitochondrial (sprot)


SARM1_HUMAN NAD(+) hydrolase SARM1 (sprot)


S29A1_RAT Equilibrative nucleoside transporter 1 (sprot)


KCNA4_RAT Potassium voltage-gated channel subfamily A member 4 (sprot)


Niclosamide

An antihelmintic that is active against most tapeworms. (From Martindale, The Extra Pharmacopoeia, 30th ed, p48). Although suggested as a potential treatment for COVID-19 based on its broad antiviral activity, including in vitro activity against coronaviruses, there are no data to support the use of niclosamide in the treatment of COVID-19.


ACHA7_MOUSE Neuronal acetylcholine receptor subunit alpha-7 (sprot)


ACHA9_RAT Neuronal acetylcholine receptor subunit alpha-9 (sprot)


CRTY_PANAN Lycopene beta-cyclase (sprot)


ACH4_DROME Acetylcholine receptor subunit beta-like 2 (sprot)


ACHA4_CHICK Neuronal acetylcholine receptor subunit alpha-4 (sprot)


ACHA4_MOUSE Neuronal acetylcholine receptor subunit alpha-4 (sprot)


ACHB3_RAT Neuronal acetylcholine receptor subunit beta-3 (sprot)


ACHA5_RAT Neuronal acetylcholine receptor subunit alpha-5 (sprot)


ACHA_RAT Acetylcholine receptor subunit alpha (sprot)


ACHB_RAT Acetylcholine receptor subunit beta (sprot)


ACHA6_RAT Neuronal acetylcholine receptor subunit alpha-6 (sprot)


ACH10_RAT Neuronal acetylcholine receptor subunit alpha-10 (sprot)


KCND3_RAT Potassium voltage-gated channel subfamily D member 3 (sprot)


GLRA3_HUMAN Glycine receptor subunit alpha-3 (sprot)


CAC1C_CAVPO Voltage-dependent L-type calcium channel subunit alpha-1C (sprot)


KCNA1_MOUSE Potassium voltage-gated channel subfamily A member 1 (sprot)


KCNA2_RAT Potassium voltage-gated channel subfamily A member 2 (sprot)


Niflumic acid

An analgesic and anti-inflammatory agent used in the treatment of rheumatoid arthritis.


CLCKA_HUMAN Chloride channel protein ClC-Ka (sprot)


CLCKB_HUMAN Chloride channel protein ClC-Kb (sprot)


SOX18_MOUSE Transcription factor SOX-18 (sprot)


NTRK2_HUMAN BDNF/NT-3 growth factors receptor (sprot)


NTRK3_HUMAN NT-3 growth factor receptor (sprot)


TAOK1_HUMAN Serine/threonine-protein kinase TAO1 (sprot)


ILK_HUMAN Integrin-linked protein kinase (sprot)


S6A19_RAT Sodium-dependent neutral amino acid transporter B(0)AT1 (sprot)


L8I2E6_9CETA Dipeptidyl peptidase 3 (trembl)


CAC1D_MOUSE Voltage-dependent L-type calcium channel subunit alpha-1D (sprot)


PNO_CRYPV Pyruvate dehydrogenase [NADP(+)] (sprot)


Q24982_GIAIN Pyruvate:ferredoxin oxidoreductase (trembl)


Q0P8E1_CAMJE Pyruvate-flavodoxin oxidoreductase (trembl)


HPPD_HUMAN 4-hydroxyphenylpyruvate dioxygenase (sprot)


HPPD_PIG 4-hydroxyphenylpyruvate dioxygenase (sprot)


HPPD_RAT 4-hydroxyphenylpyruvate dioxygenase (sprot)


PTAFR_CAVPO Platelet-activating factor receptor (sprot)


VM1B1_BOTAS Snake venom metalloproteinase BaP1 (sprot)


CGL_HUMAN Cystathionine gamma-lyase (sprot)


Nomifensine

An isoquinoline derivative that prevents dopamine reuptake into synaptosomes. The maleate was formerly used in the treatment of depression. It was withdrawn worldwide in 1986 due to the risk of acute hemolytic anemia with intravascular hemolysis resulting from its use. In some cases, renal failure also developed. (From Martindale, The Extra Pharmacopoeia, 30th ed, p266)


HBB_HUMAN Hemoglobin subunit beta (sprot)


ADA1B_MESAU Alpha-1B adrenergic receptor (sprot)


ADA2C_MOUSE Alpha-2C adrenergic receptor (sprot)


ADA2A_MOUSE Alpha-2A adrenergic receptor (sprot)


KCJ10_HUMAN ATP-sensitive inward rectifier potassium channel 10 (sprot)


Novobiocin

An antibiotic compound derived from Streptomyces niveus. It has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, and blocks adenosine triphosphatase (ATPase) activity. (From Reynolds, Martindale The Extra Pharmacopoeia, 30th ed, p189)


Q7X1P7_STREE DNA topoisomerase (ATP-hydrolyzing) (Fragment) (trembl)


C3SLN2_ECOLX DNA gyrase subunit B (trembl)


C3SLN3_ECOLX DNA gyrase subunit B (trembl)


PARE_STAAU DNA topoisomerase 4 subunit B (sprot)


SSR5_MOUSE Somatostatin receptor type 5 (sprot)


POL_HTL1A Gag-Pro-Pol polyprotein (sprot)


ATP4B_PIG Potassium-transporting ATPase subunit beta (sprot)


ATP4A_PIG Potassium-transporting ATPase alpha chain 1 (sprot)


ATP4B_RABIT Potassium-transporting ATPase subunit beta (sprot)


ATP4A_RABIT Potassium-transporting ATPase alpha chain 1 (sprot)


DGLA_HUMAN Diacylglycerol lipase-alpha (sprot)


DGLB_HUMAN Diacylglycerol lipase-beta (sprot)


ABHGA_HUMAN Phosphatidylserine lipase ABHD16A (sprot)


ABD12_HUMAN Lysophosphatidylserine lipase ABHD12 (sprot)


PAFA_HUMAN Platelet-activating factor acetylhydrolase (sprot)


LIPP_PIG Pancreatic triacylglycerol lipase (sprot)


ABHD6_HUMAN Monoacylglycerol lipase ABHD6 (sprot)


DGLA_MOUSE Diacylglycerol lipase-alpha (sprot)


LIPC_HUMAN Hepatic triacylglycerol lipase (sprot)


LIPP_HUMAN Pancreatic triacylglycerol lipase (sprot)


LIPG_HUMAN Gastric triacylglycerol lipase (sprot)


Phenindione

An indandione that has been used as an anticoagulant. Phenindione has actions similar to WARFARIN, but it is now rarely employed because of its higher incidence of severe adverse effects. (From Martindale, The Extra Pharmacopoeia, 30th ed, p234)


Q2LFS1_9INFA Neuraminidase (Fragment) (trembl)


UMPS_HUMAN Uridine 5'-monophosphate synthase (sprot)


Ouabain

A cardioactive glycoside consisting of rhamnose and ouabagenin, obtained from the seeds of Strophanthus gratus and other plants of the Apocynaceae; used like DIGITALIS. It is commonly used in cell biological studies as an inhibitor of the NA(+)-K(+)-EXCHANGING ATPASE.


HYES_MOUSE Bifunctional epoxide hydrolase 2 (sprot)


HYES_RAT Bifunctional epoxide hydrolase 2 (sprot)


Oxatomide

orally active H1-histamine receptor antagonist used to treat chronic urticaria and allergic rhinitis


ADA2A_PIG Alpha-2A adrenergic receptor (sprot)


ADA2B_MOUSE Alpha-2B adrenergic receptor (sprot)


Oxyphenbutazone

A non-steroidal anti-inflammatory drug. Oxyphenbutazone eyedrops have been used abroad in the management of postoperative ocular inflammation, superficial eye injuries, and episcleritis. (From AMA, Drug Evaluations Annual, 1994, p2000) It had been used by mouth in rheumatic disorders such as ankylosing spondylitis, osteoarthritis, and rheumatoid arthritis but such use is no longer considered justified owing to the risk of severe hematological adverse effects. (From Martindale, The Extra Pharmacopoeia, 30th ed, p27)


PTGIS_HUMAN Prostacyclin synthase (sprot)


Oxyphenonium

A quaternary ammonium anticholinergic agent with peripheral side effects similar to those of ATROPINE. It is used as an adjunct in the treatment of gastric and duodenal ulcer, and to relieve visceral spasms. The drug has also been used in the form of eye drops for mydriatic effect.


NEU1_HUMAN Oxytocin-neurophysin 1 (sprot)


Palmitoylethanolamide

a cannabinoid receptor-inactive eCB-related molecule used as prophylactic in helping to prevent respiratory viral infection; structure


GPR55_HUMAN G-protein coupled receptor 55 (sprot)


HPRT_TRYBB Hypoxanthine-guanine phosphoribosyltransferase (sprot)


Q81VW8_BACAN Dihydropteroate synthase (trembl)


HPPK_MYCTO 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase (sprot)


PDE10_RAT cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (sprot)


PDE1A_BOVIN Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A (sprot)


PDE1B_BOVIN Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B (sprot)


PDE1B_RAT Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B (sprot)


PDE1C_RAT Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C (sprot)


ARBK1_BOVIN Beta-adrenergic receptor kinase 1 (sprot)


Pefloxacin

A synthetic broad-spectrum fluoroquinolone antibacterial agent active against most gram-negative and gram-positive bacteria.


E2QDN0_ECOLX Thymidylate synthase (trembl)


PUR2_MOUSE Trifunctional purine biosynthetic protein adenosine-3 (sprot)


PUR2_HUMAN Trifunctional purine biosynthetic protein adenosine-3 (sprot)


A1AG1_HUMAN Alpha-1-acid glycoprotein 1 (sprot)


Penfluridol

One of the long-acting ANTIPSYCHOTIC AGENTS used for maintenance or long-term therapy of SCHIZOPHRENIA and other PSYCHOTIC DISORDERS.


Pentagastrin

A synthetic pentapeptide that has effects like gastrin when given parenterally. It stimulates the secretion of gastric acid, pepsin, and intrinsic factor, and has been used as a diagnostic aid.


AOC1_HUMAN Amiloride-sensitive amine oxidase [copper-containing] (sprot)


SAT1_HUMAN Diamine acetyltransferase 1 (sprot)


TP4A3_HUMAN Protein tyrosine phosphatase type IVA 3 (sprot)


TP4A2_HUMAN Protein tyrosine phosphatase type IVA 2 (sprot)


TP4A1_HUMAN Protein tyrosine phosphatase type IVA 1 (sprot)


Pentolinium

A nicotinic antagonist that has been used as a ganglionic blocking agent in hypertension.


Q86GS5_PLAFA Adenosine deaminase (trembl)


Perhexiline

2-(2,2-Dicyclohexylethyl)piperidine. Coronary vasodilator used especially for angina of effort. It may cause neuropathy and hepatitis.


CPT2_HUMAN Carnitine O-palmitoyltransferase 2, mitochondrial (sprot)


CPT1A_RAT Carnitine O-palmitoyltransferase 1, liver isoform (sprot)


Phenazocine

An opioid analgesic with actions and uses similar to MORPHINE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1095)


AOC3_HUMAN Membrane primary amine oxidase (sprot)


Phenformin

A biguanide hypoglycemic agent with actions and uses similar to those of METFORMIN. Although it is generally considered to be associated with an unacceptably high incidence of lactic acidosis, often fatal, it is still available in some countries. (From Martindale, The Extra Pharmacopoeia, 30th ed, p290)


PPBI_BOVIN Intestinal-type alkaline phosphatase (sprot)


GP139_HUMAN Probable G-protein coupled receptor 139 (sprot)


XIAP_HUMAN E3 ubiquitin-protein ligase XIAP (sprot)


Picrotoxin

A noncompetitive antagonist at GABA-A receptors and thus a convulsant. Picrotoxin blocks the GAMMA-AMINOBUTYRIC ACID-activated chloride ionophore. Although it is most often used as a research tool, it has been used as a CNS stimulant and an antidote in poisoning by CNS depressants, especially the barbiturates.


Picrotin

the less toxic component of picrotoxin lacking GABA activity


ACM1_DROME Muscarinic acetylcholine receptor DM1 (sprot)


PP2BC_HUMAN Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform (sprot)


FKB1A_RAT Peptidyl-prolyl cis-trans isomerase FKBP1A (sprot)


UBP1_HUMAN Ubiquitin carboxyl-terminal hydrolase 1 (sprot)


CAC1H_RAT Voltage-dependent T-type calcium channel subunit alpha-1H (sprot)


PPARG_MOUSE Peroxisome proliferator-activated receptor gamma (sprot)


PPARG_RAT Peroxisome proliferator-activated receptor gamma (sprot)


CISD1_RAT CDGSH iron-sulfur domain-containing protein 1 (sprot)


CISD2_HUMAN CDGSH iron-sulfur domain-containing protein 2 (sprot)


GBRB_CAEEL Gamma-aminobutyric acid receptor subunit beta (sprot)


TEAD1_HUMAN Transcriptional enhancer factor TEF-1 (sprot)


TEAD2_HUMAN Transcriptional enhancer factor TEF-4 (sprot)


TEAD3_HUMAN Transcriptional enhancer factor TEF-5 (sprot)


Pirmenol

an antiarrhythmic with class Ia activity


Pirprofen

anti-inflammatory agent used in therapy of rheumatoid arthritis; prostaglandin synthetase inhibitor; more potent than indomethacin; structure


Pizotifen

Serotonin antagonist used against MIGRAINE DISORDERS and vascular headaches.


GHSR_RAT Growth hormone secretagogue receptor type 1 (sprot)


GHSR_HUMAN Growth hormone secretagogue receptor type 1 (sprot)


RAMP2_HUMAN Receptor activity-modifying protein 2 (sprot)


RAMP1_HUMAN Receptor activity-modifying protein 1 (sprot)


RAMP3_HUMAN Receptor activity-modifying protein 3 (sprot)


R1AB_MERS1 Replicase polyprotein 1ab (sprot)


GST26_SCHJA Glutathione S-transferase class-mu 26 kDa isozyme (sprot)


Q95US7_SCHMA High voltage-activated calcium channel beta subunit CavB1 (trembl)


Q962H3_SCHMA High voltage-activated calcium channel beta subunit CavB2 (trembl)


GPBAR_HUMAN G-protein coupled bile acid receptor 1 (sprot)


ADA17_HUMAN Disintegrin and metalloproteinase domain-containing protein 17 (sprot)


Pregnenolone succinate

A 21-carbon steroid, derived from CHOLESTEROL and found in steroid hormone-producing tissues. Pregnenolone is the precursor to GONADAL STEROID HORMONES and the adrenal CORTICOSTEROIDS.