Belumosudil is an inhibitor of rho-associated, coiled-coil containing protein kinase (ROCK) which inhibits ROCK2 and ROCK1 with IC50 values of approximately 100 nanoM and 3 microM, respectively. Belumosudil downregulated proinflammatory responses via regulation of STAT3/STAT5 phosphorylation and shifting Th17/Treg balance in ex-vivo or in vitro-human T cell assays. Belumosudil also inhibited aberrant pro-fibrotic signaling, in vitro. In vivo, belumosudil demonstrated activity in animal models of chronic GVHD.


Odevixibat

Odevixibat is a reversible inhibitor of the ileal bile acid transporter (IBAT). It decreases the reabsorption of bile acids (primarily the salt forms) from the terminal ileum. Pruritus is a common symptom in patients with PFIC and the pathophysiology of pruritus in patients with PFIC is not completely understood. Although the complete mechanism by which odevixibat improves pruritus in PFIC patients is unknown, it may involve inhibition of the IBAT, which results in decreased reuptake of bile salts, as observed by a decrease in serum bile acids.


progressive familial intrahepatic cholestasis

biolink:Disease biolink:DiseaseOrPhenotypicFeature biolink:ThingWithTaxon biolink:BiologicalEntity biolink:NamedThing biolink:Entity


belzutifan

Belzutifan is an inhibitor of hypoxia-inducible factor 2 alpha (HIF-2alpha), with potential antineoplastic activity. HIF-2alpha is a transcription factor that plays a role in oxygen sensing by regulating genes that promote adaptation to hypoxia. Under normal oxygen levels, HIF-2alpha is targeted for ubiquitin-proteasomal degradation by VHL protein. Lack of functional VHL protein results in stabilization and accumulation of HIF-2alpha. Upon stabilization, HIF-2alpha translocates into the nucleus and interacts with hypoxia-inducible factor 1 beta (HIF-1beta) to form a transcriptional complex that induces expression of downstream genes, including genes associated with cellular proliferation, angiogenesis, and tumor growth. Belzutifan binds to HIF-2alpha, and in conditions of hypoxia or impairment of VHL protein function, belzutifan blocks the HIF-2alpha-HIF-1beta interaction, leading to reduced transcription and expression of HIF-2alpha target genes. In vivo, belzutifan demonstrated anti-tumor activity in mouse xenograft models of renal cell carcinoma.


Difelikefalin

Difelikefalin is a kappa opioid receptor (KOR) agonist. The relevance of KOR activation to therapeutic effectiveness is not known.


Uremic pruritus

biolink:PhenotypicFeature biolink:DiseaseOrPhenotypicFeature biolink:ThingWithTaxon biolink:BiologicalEntity biolink:NamedThing biolink:Entity


Mobocertinib

Mobocertinib is a kinase inhibitor of the epidermal growth factor receptor (EGFR) that irreversibly binds to and inhibits EGFR exon 20 insertion mutations at lower concentrations than wild type (WT) EGFR. Two pharmacologically-active metabolites (AP32960 and AP32914) with similar inhibitory profiles to mobocertinib have been identified in the plasma after oral administration of mobocertinib. In vitro, mobocertinib also inhibited the activity of other EGFR family members (HER2 and HER4) and one additional kinase (BLK) at clinically relevant concentrations (IC50 values <2 nM).


Atogepant

Atogepant is a calcitonin gene-related peptide (CGRP) receptor antagonist.


Migraine prophylaxis

biolink:Procedure biolink:ActivityAndBehavior biolink:NamedThing biolink:Entity biolink:Occurrent biolink:PhysicalEssenceOrOccurrent


anifrolumab

Anifrolumab-fnia is a human IgG1kappa monoclonal antibody that binds to subunit 1 of the type I interferon receptor (IFNAR) with high specificity and affinity. This binding inhibits type I IFN signaling, thereby blocking the biologic activity of type I IFNs. Anifrolumab-fnia also induces the internalization of IFNAR1, thereby reducing the levels of cell surface IFNAR1 available for receptor assembly. Blockade of receptor mediated type I IFN signaling inhibits IFN responsive gene expression as well as downstream inflammatory and immunological processes. Inhibition of type I IFN blocks plasma cell differentiation and normalizes peripheral T-cell subsets. Type I IFNs play a role in the pathogenesis of SLE. Approximately 60-80% of adult patients with active SLE express elevated levels of type I IFN inducible genes.


avalglucosidase alfa

Avalglucosidase alfa-ngpt provides an exogenous source of GAA. The M6P on avalglucosidase alfa-ngpt mediates binding to M6P receptors on the cell surface with high affinity. After binding, it is internalized and transported into lysosomes where it undergoes proteolytic cleavage that results in increased GAA enzymatic activity. Avalglucosidase alfa-ngpt then exerts enzymatic activity in cleaving glycogen.


glycogen storage disease due to acid maltase deficiency, late-onset


LONAPEGSOMATROPIN

Lonapegsomatropin is a pegylated human growth hormone (somatropin) for once-weekly subcutaneous injection. Somatropin binds to the growth hormone (GH) receptor in the cell membrane of target cells resulting in intracellular signal transduction and a host of pharmacodynamic effects. Somatropin has direct tissue and metabolic effects, and indirect effects mediated by insulin-like growth factor-1 (IGF-1), including stimulation of chondrocyte differentiation and proliferation, stimulation of hepatic glucose output, protein synthesis and lipolysis. Somatropin stimulates skeletal growth in pediatric patients with growth hormone deficiency (GHD) as a result of effects on the growth plates (epiphyses) of long bones.


tisotumab vedotin

Tisotumab vedotin-tftv is a tissue factor (TF)-directed antibody drug conjugate (ADC). The antibody is a human IgG1 directed against cell surface TF. TF is the primary initiator of the extrinsic blood coagulation cascade. The small molecule, MMAE, is a microtubule-disrupting agent, attached to the antibody via a protease-cleavable linker. Nonclinical data suggests that the anticancer activity of tisotumab vedotin-tftv is due to the binding of the ADC to TF expressing cancer cells, followed by internalization of the ADC-TF complex, and release of MMAE via proteolytic cleavage. MMAE disrupts the microtubule network of actively dividing cells, leading to cell cycle arrest and apoptotic cell death. In vitro, tisotumab vedotin-tftv also mediates antibody-dependent cellular phagocytosis and antibody-dependent cellular cytotoxicity.


BIMEKIZUMAB

Bimekizumab is a humanised IgG1/kappa monoclonal antibody that selectively binds with high affinity to IL-17A, IL-17F and IL-17AF cytokines, blocking their interaction with the IL-17RA/IL-17RC receptor complex. Elevated concentrations of IL-17A and IL-17F have been implicated in the pathogenesis of several immune-mediated inflammatory diseases including plaque psoriasis. Bimekizumab inhibits these proinflammatory cytokines, resulting in the normalization of skin inflammation and as a consequence improvement in clinical symptoms associated with psoriasis. From in vitro models, bimekizumab was shown to inhibit psoriasis-related gene expression and cytokine production to a greater extent than inhibition of IL-17A alone.


obesity due to pro-opiomelanocortin deficiency


Obesity due to leptin receptor gene deficiency


TRALOKINUMAB

Tralokinumab is a fully human IgG4 monoclonal antibody that specifically binds to the type 2 cytokine interleukin-13 (IL-13) and inhibits its interaction with the IL-13 receptors. Tralokinumab neutralises the biological activity of IL-13 by blocking its interaction with the IL-13Ralpha1/IL-4Ralpha receptor complex. IL-13 is a major driver of human type 2 inflammatory disease, such as atopic dermatitis and inhibiting the IL-13 pathway with tralokinumab in patients decreases many of the mediators of type 2 inflammation.


Vosoritide

Vosoritide is a modified type C natriuretic peptide (CNP). In patients with achondroplasia, endochondral bone growth is negatively regulated due to a gain of function mutation in fibroblast growth factor receptor 3 (FGFR3). Binding of vosoritide to natriuretic peptide receptor-B (NPR-B) antagonises FGFR3 downstream signalling by inhibiting the extracellular signal-regulated kinases 1 and 2 (ERK1/2) in the mitogen-activated protein kinase (MAPK) pathway at the level of rapidly accelerating fibrosarcoma serine/threonine protein kinase (RAF-1). As a result, vosoritide, like CNP, acts as a positive regulator of endochondral bone growth as it promotes chondrocyte proliferation and differentiation.


Ioflupane I-123

Ioflupane binds reversibly to the human recombinant dopamine transporter (DaT). Following administration of DaTscan to humans, radioactive decay of the iodine 123 emits gamma radiation which can be detected externally using gamma detectors, allowing visualization of the brain striata through SPECT imaging. Autoradiography of post-mortem human brain slices exposed to radiolabeled ioflupane shows concentration of the radiolabel in striatum (caudate nucleus and putamen). The specificity of the binding of ioflupane I 125 to dopamine transporter was demonstrated by competition studies with the DaT inhibitor GBR 12909 (a dopamine reuptake inhibitor), the serotonin reuptake inhibitor citalopram, and the norepinephrine reuptake inhibitor desipramine in post-mortem human brain slices exposed to radiolabeled ioflupane.  Citalopram reduced binding in the neocortex and thalamus with only minor effects in the striatum. This indicated that the binding in the cortex and thalamus is mainly to the serotonin reuptake sites.  Desipramine showed no effect on the level of striatal binding of ioflupane I 125, but reduced extrastriatal binding by 60 to 85%.  The binding of ioflupane I 125 to the striatum was abolished in the presence of high concentrations of GBR 12909, indicating selectivity of ioflupane binding for the pre-synaptic DaT.


PEFICITINIB

Peficitinib inhibits the signal transduction of cytokines important for the pathological condition of RA as it inhibits the kinase activity of the JAK family (JAK1, JAK2, JAK3, and TYK2) and their signal transduction mediated by IL-2.


Imeglimin

Imeglimin is a first-in-class oral agent which improves pancreatic beta-cell function and enhances insulin action in key tissues, including liver and skeletal muscle.


Microsatellite instability-high colorectal cancer


Acute exacerbation of chronic congestive heart failure


Autologous Hematopoietic Stem Cell Transplantation


Potassium Sulfate

Potassium sulfate is used to cleanse the colon (bowel) before colonoscopy in combination with sodium sulfate and magnesium sulfate.


Molidustat

Molidustat (BAY 85–3934) is a novel, orally bioavailable HIF-PH inhibitor that mimics hypoxia by stabilizing HIF-a subunits. Molidustat inhibits HIF-PH, allowing the accumulation of HIF, which then translocates to the nucleus where it activates the transcription of erythropoietin (EPO) and other hypoxia-inducible genes, thereby increasing endogenous EPO levels and formation of the red blood cell.


Anamorelin

Anamorelin is a potent and selective novel ghrelin receptor agonist that mimics the N-terminal active core of ghrelin. ANAM stimulates neuroendocrine responses and can induce rapid positive effects on appetite and metabolism, which can lead to an increase in body weight and lean body mass.


Pabinafusp alfa

Pabinafusp alfa is a fusion protein consisting of a humanized anti-hTfR antibody and hIDS. The humanized anti-hTfR antibody is considered to bind to TfRs expressed in the luminal cell membrane of brain microvascular endothelial cells composing the blood-brain barrier, being transported together with the TfR, passing through brain microvascular endothelial cells via transcytosis (which involves the mechanisms of uptake into the cell via endocytosis and release outside the cell via exocytosis) and further penetrating the basal lamina into neuronal cells in the brain parenchyma. In addition, after binding of pabinafusp alfa to M6PR on the cell membrane and cellular uptake via endocytosis, newly formed endosomes are thought to fuse with lysosomes and move into them. In patients with MPS, the type of accumulating GAG differs depending on the MPS phenotype, and CNS symptoms develops in patients with MPS phenotypes that are associated with the accumulation of HS. HS concentrations in CSF are high in patients with MPS-II who have intellectual disability, compared with those who do not have intellectual disability. These findings and other factors have suggested that HS plays a vital role in the development of CNS symptoms. The hIDS of pabinafusp alfa is considered to promote the degradation of HS in the brain parenchyma, thereby suppressing the development or progression of CNS symptoms. It has been demonstrated that pabinafusp alfa has binding affinity for M6PR and hTfR, and is taken up by human fibroblasts via the receptors.


DICLOFENAC ETALHYALURONATE SODIUM

Diclofenac etalhyaluronate is a 130,000 kDa compound in which the diclofenac molecule is attached via a 2-aminoethanol linker to the glucuronic acid moiety of the hyaluronic acid. Diclofenac is released through hydrolytic cleavage of the ester linkage and it inhibits the synthesis of prostaglandin E2.


Esaxerenone

Esaxerenone is an oral, selective  nonsteroidal  mineralocorticoid  receptor antagonist used for the treatment of hypertension and diabetic nephropathies.


Mirogabalin besylate

Mirogabalin, a novel ligand for the alpha2delta subunit of voltage-gated calcium channels, has been approved for the treatment of peripheral neuropathic pain including painful diabetic peripheral neuropathy (DPNP) and postherpetic neuralgia (PHN) in Japan. Mirogabalin showed potent and selective binding affinities for the alpha2delta subunits, and slower dissociation rates for the alpha2delta-1 subunit than for the alpha2delta-2 subunit. It also showed potent and long-lasting analgesic effects in rat models of neuropathic pain, and wider safety margins for the central nervous system side effects. A pharmacological study using mutant mice demonstrated that the analgesic effects of mirogabalin were mediated by binding of the drug to the alpha2delta-1 subunit, not the alpha2delta-2 subunit.


secondary progressive multiple sclerosis


Anaplastic lymphoma kinase fusion oncogene positive non-small cell lung cancer


Sodium selenite

The disodium salt of selenious acid. It is used therapeutically to supply the trace element selenium and is prepared by the reaction of SELENIUM DIOXIDE with SODIUM HYDROXIDE.


Still's disease with juvenile onset and/or adult onset


Acute pyelonephritis caused by bacterium


Upacicalcet

Upacicalcet acts directly on parathyroid cell membrane calcium-sensing receptors and it suppresses excessive parathyroid hormone secretion.


Demycarosylturimycin H

A macrolide antibiotic produced by Streptomyces ambofaciens. The drug is effective against gram-positive aerobic pathogens, N. gonorrhoeae, and staphylococci. It is used to treat infections caused by bacteria and Toxoplasma gondii.


eosinophilic granulomatosis with polyangiitis


Stress echocardiography using dobutamine


Maralixibat

Maralixibat is a reversible inhibitor of the ileal bile acid transporter (IBAT). It decreases the reabsorption of bile acids (primarily the salt forms) from the terminal ileum. Pruritus is a common symptom in patients with ALGS and the pathophysiology of pruritus in patients with ALGS is not completely understood. Although the complete mechanism by which maralixibat improves pruritus in ALGS patients is unknown, it may involve inhibition of the IBAT, which results in decreased reuptake of bile salts, as observed by a decrease in serum bile acids.


Epiphysis closure

biolink:PhysiologicalProcess biolink:OntologyClass biolink:BiologicalProcess biolink:Occurrent biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:NamedThing biolink:Entity biolink:PhysicalEssenceOrOccurrent


a recombinant IL-2 product having a methionine added at the N-terminal.


idursulfase beta

Enzyme replacement therapy product for the treatment of Hunter syndrome


indocyanine green

A tricarbocyanine dye that is used diagnostically in liver function tests and to determine blood volume and cardiac output.


Nemorexant

The mechanism of action of daridorexant in the treatment of insomnia is presumed to be through antagonism of orexin receptors. The orexin neuropeptide signaling system plays a role in wakefulness. Blocking the binding of wake-promoting neuropeptides orexin A and orexin B to receptors OX1R and OX2R is thought to suppress wake drive.


avacopan

Avacopan is a complement 5a receptor (C5aR) antagonist that inhibits the interaction between C5aR and the anaphylatoxin C5a. Avacopan blocks C5a-mediated neutrophil activation and migration. The precise mechanism by which avacopan exerts a therapeutic effect in patients with ANCA-associated vasculitis has not been definitively established.


Asciminib

Asciminib is an ABL/BCR-ABL1 tyrosine kinase inhibitor. Asciminib inhibits the ABL1 kinase activity of the BCRABL1 fusion protein, by binding to the ABL myristoyl pocket. In studies conducted in vitro or in animal models of CML, asciminib showed activity against wild-type BCR-ABL1 and several mutant forms of the kinase, including the T315I mutation.


Maribavir

Livtencity is an antiviral drug against human cytomegalovirus. The antiviral activity of maribavir is mediated by competitive inhibition of the protein kinase activity of human CMV enzyme pUL97, which results in inhibition of the phosphorylation of proteins. Maribavir inhibited wildtype pUL97 protein kinase in a biochemical assay with an IC50 value of 0.003 microM.


pafolacianine

Cytalux is a fluorescent drug that targets folate receptor (FR) which may be overexpressed in ovarian cancer. Pafolacianine binds to FR-expressing cancer cells with affinity of approximately 1 nM, internalizes via receptor mediated endocytosis, and concentrates in FR-positive cancer tissues.


Cemdisiran

Inclisiran is a double-stranded small interfering ribonucleic acid (siRNA), conjugated on the sense strand with triantennary N-Acetylgalactosamine (GalNAc) to facilitate uptake by hepatocytes. In hepatocytes, inclisiran utilizes the RNA interference mechanism and directs catalytic breakdown of mRNA for PCSK9. This increases LDL-C receptor recycling and expression on the hepatocyte cell surface, which increases LDL-C uptake and lowers LDL-C levels in the circulation.


EFGARTIGIMOD ALFA

Efgartigimod alfa-fcab is a human IgG1 antibody fragment that binds to the neonatal Fc receptor (FcRn), resulting in the reduction of circulating IgG.


tezepelumab

Tezepelumab-ekko is a thymic stromal lymphopoietin (TSLP) blocker, human monoclonal antibody IgG2lambda that binds to human TSLP with a dissociation constant of 15.8 pM and blocks its interaction with the heterodimeric TSLP receptor. TSLP is a cytokine mainly derived from epithelial cells and occupies an upstream position in the asthma inflammatory cascade. Airway inflammation is an important component in the pathogenesis of asthma. Multiple cell types (e.g., mast cells, eosinophils, neutrophils, macrophages, lymphocytes, ILC2 cells) and mediators (e.g., histamine, eicosanoids, leukotrienes, cytokines) are involved in airway inflammation. Blocking TSLP with tezepelumab-ekko reduces biomarkers and cytokines associated with inflammation including blood eosinophils, airway submucosal eosinophils, IgE, FeNO, IL-5, and IL-13; however, the mechanism of tezepelumab-ekko action in asthma has not been definitively established.


Immunosuppressive therapy for transplant


diroximel fumarate

The mechanism by which diroximel fumarate exerts therapeutic effects in MS is not fully understood. Diroximel fumarate acts via the major active metabolite, monomethyl fumarate. Preclinical studies indicate that the pharmacodynamic responses of monomethyl fumarate appears to be mediated, at least in part, through activation of the Nuclear factor (erythroid-derived 2)-like 2 (Nrf2) transcriptional pathway. Dimethyl fumarate has been shown to up regulate Nrf2-dependent antioxidant genes in patients.


difamilast

Difamilast is a novel atopic dermatitis drug that has phosphodiesterase 4 inhibitory activity. PDE4 inhibitors are believed to improve the symptoms of atopic dermatitis through suppression of the production of chemical mediators such as pro-inflammatory cytokines and through other anti-inflammatory effects.


ABROCITINIB

Abrocitinib is a Janus kinase (JAK)1 inhibitor. JAKs phosphorylate and activate Signal Transducers and Activators of Transcription (STATs) which modulate intracellular activity including gene expression. Inhibition of JAK1 modulates the signalling pathways by preventing the phosphorylation and activation of STATs. It is used for  treating adults with moderate to severe atopic dermatitis (also known as eczema, when the skin is itchy, red and dry).


Iobenguane (131I)

AZEDRA is an I 131 labeled iobenguane. Iobenguane is similar in structure to the neurotransmitter norepinephrine (NE) and is subject to the same uptake and accumulation pathways as NE. Iobenguane is taken up by the NE transporter in adrenergic nerve terminals and accumulates in adrenergically innervated tissues, such as the heart, lungs, adrenal medulla, salivary glands, liver, and spleen as well as tumors of neural crest origin. Pheochromocytoma and paraganglioma (PPGL) are tumors of neural crest origin that express high levels of the NE transporter on their cell surfaces. Following intravenous administration, AZEDRA is taken up and accumulates within pheochromocytoma and paraganglioma cells, and radiation resulting from radioactive decay of I 131 causes cell death and tumor necrosis.


sotrovimab

Sotrovimab is a human IgG1 mAb that binds to a highly conserved epitope on the spike protein receptor binding domain of SARS-CoV-2.


REGDANVIMAB

Regdanvimab is a recombinant human IgG1 monoclonal antibody that binds to the receptor binding domain (RBD) of the spike(s) protein of SARS-CoV-2 consequently blocking cellular entry and SARS-CoV-2 infection.


Oteseconazole

Oteseconazole is an azole metalloenzyme inhibitor targeting the fungal sterol, 14alpha demethylase(CYP51), an enzyme that catalyzes an early step in the biosynthetic pathway of ergosterol, a sterol required for fungal cell membrane formation and integrity. Inhibition of CYP51 results in the accumulation of 14-methylated sterols, some of which are toxic to fungi. Through the inclusion of a tetrazole metal-binding group, oteseconazole has a lower affinity for human CYP enzymes.


SUTIMLIMAB

Sutimlimab-jome is an immunoglobulin G (IgG), subclass 4 (IgG4) monoclonal antibody (mAb) that inhibits the classical complement pathway (CP) and specifically binds to complement protein component 1, s subcomponent (C1s), a serine protease which cleaves C4. Sutimlimab-jome does not inhibit the lectin and alternative pathways. Inhibition of the classical complement pathway at the level of C1s prevents deposition of complement opsonins on the surface of RBCs, resulting in inhibition of hemolysis in patients with CAD.


TEBENTAFUSP

Tebentafusp-tebn is a bispecific gp100 peptide-HLA-A02:01 directed T cell receptor CD3 T cell engager. The TCR arm binds to a gp100 peptide presented by human leukocyte antigen-A*02:01 (HLA¬ A02:01) on the cell surface of uveal melanoma tumor cells. In vitro, tebentafusp-tebn bound to HLA-A02:01-positive uveal melanoma cells and activated polyclonal T cells to release inflammatory cytokines and cytolytic proteins, which results in direct lysis of uveal melanoma tumor cells.


relatlimab

Relatlimab is a human IgG4 monoclonal antibody that binds to the LAG-3 receptor, blocks interaction with its ligands, including MHC II, and reduces LAG-3 pathway-mediated inhibition of the immune response. Antagonism of this pathway promotes T cell proliferation and cytokine secretion. Binding of the PD-1 ligands, PD-L1 and PD-L2, to the PD-1 receptor found on T cells, inhibits T-cell proliferation and cytokine production. Upregulation of PD-1 ligands occurs in some tumors, and signaling through this pathway can contribute to inhibition of active T-cell immune surveillance of tumors. Nivolumab is a human IgG4 monoclonal antibody that binds to the PD-1 receptor, blocks interaction with its ligands PD-L1 and PD-L2, and reduces PD-1 pathwaymediated inhibition of the immune response, including the anti-tumor immune response. In syngeneic mouse tumor models, blocking PD-1 activity resulted in decreased tumor growth. The combination of nivolumab (anti-PD-1) and relatlimab (anti-LAG-3) results in increased T-cell activation compared to the activity of either antibody alone. In murine syngeneic tumor models, LAG-3 blockade potentiates the anti-tumor activity of PD-1 blockage, inhibiting tumor growth and promoting tumor regression.


faricimab

Faricimab is a humanized bispecific antibody that acts through inhibition of two pathways by binding to VEGF-A and Ang-2. By inhibiting VEGF-A, faricimab suppresses endothelial cell proliferation, neovascularization and vascular permeability. By inhibiting Ang-2, faricimab is thought to promote vascular stability and desensitize blood vessels to the effects of VEGF-A. Ang-2 levels are increased in some patients with nAMD and DME. The contribution of Ang-2 inhibition to the treatment effect and clinical response for nAMD and DME has yet to be established.


Infection of skin of eyelid and periocular region


Tirzepatide

Tirzepatide is a GIP receptor and GLP-1 receptor agonist. It is a 39-amino-acid modified peptide with a C20 fatty diacid moiety that enables albumin binding and prolongs the half-life. Tirzepatide selectively binds to and activates both the GIP and GLP-1 receptors, the targets for native GIP and GLP-1. Tirzepatide enhances first- and second-phase insulin secretion, and reduces glucagon levels, both in a glucosedependent manner.


SOMATROGON

Somatrogon is a glycoprotein comprised of the amino acid sequence of hGH with one copy of the of C-terminal peptide (CTP) from the beta chain of human chorionic gonadotropin (hCG) at the N-terminus and two copies of CTP (in tandem) at the C-terminus. The glycosylation and CTP domains account for the half-life of somatrogon, which allows for weekly dosing. Somatrogon binds to the GH receptor and initiates a signal transduction cascade culminating in changes in growth and metabolism. Consistent with GH signalling, somatrogon binding leads to activation of the STAT5b signalling pathway and increases the serum concentration of IGF-1. IGF-1 was found to increase in a dose-dependent manner during treatment with somatrogon partially mediating the clinical effect. As a result, GH and IGF-1 stimulate metabolic changes, linear growth and enhance growth velocity in paediatric patients with GHD.


Clazosentan

Clazosentan is an endothelin receptor antagonist indicated for the prevention of cerebrovascular spasm after surgery for subarachnoid hemorrhage caused by cerebral aneurysm, and cerebral infarctions and cerebral ischemic symptoms accompanying the cerebrovascular spasm.


gefapixant

Gefapixant is a selective, non-narcotic P2X3 receptor antagonist being approved for the treatment of refractory chronic cough or unexplained chronic cough.


Nirmatrelvir

Nirmatrelvir plus ritonavir (Paxlovid) is an antiviral therapeutic developed by Pfizer for the treatment and post-exposure prophylaxis of coronavirus disease 2019 (COVID-19). It received conditional approval  by EMA, FDA and PMDA. Nirmatrelvir (PF-07321332) is a peptidomimetic inhibitor of the SARS-CoV-2 main protease (Mpro), also referred to as 3C-like protease (3CLpro) or nsp5 protease. Inhibition of the SARS-CoV-2 Mpro renders the protein incapable of processing polyprotein precursors which leads to the prevention of viral replication. Ritonavir inhibits the CYP3A-mediated metabolism of PF-07321332, thereby providing increased plasma concentrations of PF-07321332.


Tapinarof is an aryl hydrocarbon receptor (AhR) agonist. The specific mechanisms by which VTAMA cream exerts its therapeutic action in psoriasis patients are unknown.


Mitapivat is a pyruvate kinase activator that acts by allosterically binding to the pyruvate kinase tetramer and increasing pyruvate kinase (PK) activity. The red blood cell (RBC) form of pyruvate kinase (PK-R) is mutated in PK deficiency, which leads to reduced adenosine triphosphate(ATP), shortened RBC lifespan, and chronic hemolysis.


Pacritinib

Pacritinib is a kinase inhibitor with activity against Janus-associated kinase 2 (JAK2) and Fms-like receptor tyrosine kinase 3 (FLT3). Pacritinib inhibits both wild-type JAK2 and the JAK2V617F mutant form that is common in patients with myeloproliferative neoplasms. Pacritinib also exhibits inhibitory activity against additional cellular kinases (such as colony-stimulating factor 1 and interleukin 1 receptor-associated kinase 1), the clinical relevance of which is unknown.


Ganaxolone

The precise mechanism by which ganaxolone exerts its therapeutic effects in the treatment of seizures associated with CDD is unknown, but its anticonvulsant effects are thought to result from positive allosteric modulation of the gamma-aminobutyric acid type A (GABAA) receptor in the CNS.


developmental and epileptic encephalopathy, 2


PSMA-617 Lu-177

Lutetium Lu 177 vipivotide tetraxetan is a radioligand therapeutic agent. The active moiety of lutetium Lu 177 vipivotide tetraxetan is the radionuclide lutetium-177 which is linked to a moiety that binds to PSMA, a transmembrane protein that is expressed in prostate cancer, including mCRPC. Upon binding of lutetium Lu 177 vipivotide tetraxetan to PSMA- expressing cells, the beta-minus emission from lutetium-177 delivers radiation to PSMA-expressing cells, as well as to surrounding cells, and induces DNA damage which can lead to cell death.


Mavacamten

Mavacamten is an allosteric and reversible inhibitor selective for cardiac myosin. Mavacamten modulates the number of myosin heads that can enter “on actin” (power-generating) states, thus reducing the probability of force-producing (systolic) and residual (diastolic) cross-bridge formation. Excess myosin actin cross-bridge formation and dysregulation of the super-relaxed state are mechanistic hallmarks of HCM. Mavacamten shifts the overall myosin population towards an energy-sparing, recruitable, super-relaxed state. In HCM patients, myosin inhibition with mavacamten reduces dynamic LVOT obstruction and improves cardiac filling pressures.


EIDD-1931 has broad spectrum antiviral activity against SARS-CoV-2, MERS-CoV, SARS-CoV, and related zoonotic group 2b or 2c Bat-CoVs, as well as increased potency against a coronavirus bearing resistance mutations to the nucleoside analog inhibitor remdesivir


Phthalylsulfathiazole

minor descriptor (63-86); on-line & INDEX MEDICUS search SULFATHIAZOLES (66-86); RN given refers to parent cpd


Sodium Chloride

A ubiquitous sodium salt that is commonly used to season food.


Metamizole

A drug that has analgesic, anti-inflammatory, and antipyretic properties. It is the sodium sulfonate of AMINOPYRINE.


ICODEXTRIN

A glucan that is structurally related to maltodextrin, with more than 85% of its molecules having molecular weights between 1640 and 45 000 Daltons (Da), and a weight-average molecular weight of about 20 000 Da; it is used in dialysis fluids as an alternative to glucose-based solutions, and to reduce adhesions after gynecological or abdominal surgery. It has also been used as a vehicle for drugs given via the peritoneal cavity.


Oxygen

An element with atomic symbol O, atomic number 8, and atomic weight [15.99903; 15.99977]. It is the most abundant element on earth and essential for respiration.


CHORIOGONADOTROPIN ALFA

Choriogonadotropin alfa, is an analogue of Luteinizing Hormone (LH) and binds to the LH/hCG receptor of the granulosa and theca cells of the ovary to effect these changes in the absence of an endogenous LH surge. In pregnancy, hCG, secreted by the placenta, maintains the viability of the corpus luteum to provide the continued secretion of estrogen and progesterone necessary to support the first trimester of pregnancy.


ATROPINE

An alkaloid, originally from Atropa belladonna, but found in other plants, mainly SOLANACEAE. Hyoscyamine is the 3(S)-endo isomer of atropine.


Sodium Bicarbonate

A white, crystalline powder that is commonly used as a pH buffering agent, an electrolyte replenisher, systemic alkalizer and in topical cleansing solutions.


Accident while engaged in work-related activity


Nordazepam

An intermediate in the metabolism of DIAZEPAM to OXAZEPAM. It may have actions similar to those of diazepam.


Activated partial thromboplastin time abnormal


Activated partial thromboplastin time shortened


Bromazepam

One of the BENZODIAZEPINES that is used in the treatment of ANXIETY DISORDERS.


Fenoterol

A synthetic adrenergic beta-2 agonist that is used as a bronchodilator and tocolytic.


Tiapride

A benzamide derivative that is used as a dopamine antagonist.


Nefopam

Non-narcotic analgesic chemically similar to ORPHENADRINE. Its mechanism of action is unclear. It is used for the relief of acute and chronic pain. (From Martindale, The Extra Pharmacopoeia, 30th ed, p26)


Carbon Dioxide

A solid form of carbon dioxide used as a refrigerant.


Elevated circulating alanine aminotransferase concentration


Mosapride

Mosapride is a 5-HT4 receptor agonist which increases the release of acetylcholine and stimulates GI motility.


Glutathione

A tripeptide with many roles in cells. It conjugates to drugs to make them more soluble for excretion, is a cofactor for some enzymes, is involved in protein disulfide bond rearrangement and reduces peroxides.


Flunitrazepam

A benzodiazepine with pharmacologic actions similar to those of DIAZEPAM that can cause ANTEROGRADE AMNESIA. Some reports indicate that it is used as a date rape drug and suggest that it may precipitate violent behavior. The United States Government has banned the importation of this drug.


; RN given refers to isomeric cpd without isomeric designation; mixture of (5E,9E,13E) & (5Z,9E,13E)-isomers


Digitoxin

A cardiac glycoside sometimes used in place of DIGOXIN. It has a longer half-life than digoxin; toxic effects, which are similar to those of digoxin, are longer lasting. (From Martindale, The Extra Pharmacopoeia, 30th ed, p665)


Canrenoic acid

A synthetic pregnadiene derivative with anti-aldosterone activity.


Dimethindene

A histamine H1 antagonist. It is used in hypersensitivity reactions, in rhinitis, for pruritus, and in some common cold remedies.


Etamsylate

Benzenesulfonate derivative used as a systemic hemostatic.


TERIZIDONE

minor descriptor (1975-1984); on-line & Index Medicus search OXAZOLES (1975-1984); RN given refers to parent cpd without isomeric designation


Megaloblastic anemia due to vitamin B>12< deficiency


Nitrous Oxide

Nitrogen oxide (N2O). A colorless, odorless gas that is used as an anesthetic and analgesic. High concentrations cause a narcotic effect and may replace oxygen, causing death by asphyxia. It is also used as a food aerosol in the preparation of whipping cream.


Iohexol

An effective non-ionic, water-soluble contrast agent which is used in myelography, arthrography, nephroangiography, arteriography, and other radiographic procedures. Its low systemic toxicity is the combined result of low chemotoxicity and low osmolality.


Iodixanol

dimeric contrast media; structure given in first source


Iopamidol

A non-ionic, water-soluble contrast agent which is used in myelography, arthrography, nephroangiography, arteriography, and other radiological procedures.


Gadoteridol

nonionic magnetic resonance contrast agent; structure given in first source


Sulfur hexafluoride

Sulfur hexafluoride. An inert gas used mainly as a test gas in respiratory physiology. Other uses include its injection in vitreoretinal surgery to restore the vitreous chamber and as a tracer in monitoring the dispersion and deposition of air pollutants.


Gadopentetate dimeglumine

A complex of gadolinium with a chelating agent, diethylenetriamine penta-acetic acid (DTPA see PENTETIC ACID), that is given to enhance the image in cranial and spinal MRIs. (From Martindale, The Extra Pharmacopoeia, 30th ed, p706)


Dexketoprofen

a water-soluble tromethamine salt of the racemic ketoprofen, rac(+-)-ketoprofen


isosulfan blue

2,5-disulfobenzylidene-isomer of sulfan blue; RN given refers to Na salt


Iron(III) hydroxide

additional RNs for iron hydroxide oxide: 11115-92-7, 20344-49-4; RN for unspecified iron hydroxide: 11113-66-9


Etoricoxib

A sulfone and pyridine derivative that acts as a cyclooxygenase-2 inhibitor. It is used as a NSAID for the treatment of pain associated with RHEUMATOID ARTHRITIS and ANKYLOSING SPONDYLITIS. It is also used for the short-term treatment of moderate postoperative dental pain.


Antimicrobial susceptibility test resistant


Diacerein

chelates with bivalent metals; a quinone which possesses redox properties; metabolized to active rhein; proposed mechanisms include inhibiting IL1 and metalloproteinases; called a slow acting symptomatic drug in osteoarthritis; no effect of cyclooxygenase


Elevated circulating aspartate aminotransferase concentration


Protionamide

Antitubercular agent similar in action and side effects to ETHIONAMIDE. It is used mostly in combination with other agents.


Barium Sulfate

A compound used as an x-ray contrast medium that occurs in nature as the mineral barite. It is also used in various manufacturing applications and mixed into heavy concrete to serve as a radiation shield.


precursor B-cell acute lymphoblastic leukemia


Blood bicarbonate level decreased below normal


Blood creatine phosphokinase MB increased


Blood follicle stimulating hormone increased


Blood thyroid stimulating hormone abnormal


Blood thyroid stimulating hormone decreased


Blood thyroid stimulating hormone increased


Blood thyroid stimulating hormone normal


Abnormal blood urea nitrogen concentration


Nitrendipine

A calcium channel blocker with marked vasodilator action. It is an effective antihypertensive agent and differs from other calcium channel blockers in that it does not reduce glomerular filtration rate and is mildly natriuretic, rather than sodium retentive.


Trimebutine

Proposed spasmolytic with possible local anesthetic action used in gastrointestinal disorders.


Canrenone

A synthetic pregnadiene compound with anti-aldosterone activity.


Elevated circulating C-reactive protein concentration


An antiseptic with mild fungistatic, bacteriostatic, anthelmintic, and amebicidal action. It is also used as a reagent and metal chelator, as a carrier for radio-indium for diagnostic purposes, and its halogenated derivatives are used in addition as topical anti-infective agents and oral antiamebics.


Metildigoxin

A semisynthetic digitalis glycoside with the general properties of DIGOXIN but more rapid onset of action. Its cardiotonic action is prolonged by its demethylation to DIGOXIN in the liver. It has been used in the treatment of congestive heart failure (HEART FAILURE).


Cilnidipine

has excitatory & inhibitory action on the Ca+ channels in the rabbit basilar artery; structure given in first source; RN given is for (+-) isomer


Pimobendan

produces arterial & venous dilatation in dogs; structure given in first source


Dimyristoylphosphatidylcholine, DL-

A synthetic phospholipid used in liposomes and lipid bilayers for the study of biological membranes.


Pristinamycin

An antibiotic mixture originally isolated from Streptomyces pristinaspiralis. It is a mixture of compounds from STREPTOGRAMIN GROUP A: pristinamycin IIA and IIB and from STREPTOGRAMIN GROUP B: pristinamycin IA, pristinamycin IB, pristinamycin IC.


Phloroglucinol

A trinitrobenzene derivative with antispasmodic properties that is used primarily as a laboratory reagent.


myalgic encephalomeyelitis/chronic fatigue syndrome


Bromhexine

A mucolytic agent used in the treatment of respiratory disorders associated with viscid or excessive mucus. (From Martindale, The Extra Pharmacopoeia, 30th ed, p744)


Creatine

An amino acid that occurs in vertebrate tissues and in urine. In muscle tissue, creatine generally occurs as phosphocreatine. Creatine is excreted as CREATININE in the urine.


Congenital anomaly of central nervous system


Flavin mononucleotide

A coenzyme for a number of oxidative enzymes including NADH DEHYDROGENASE. It is the principal form in which RIBOFLAVIN is found in cells and tissues.


Avobenzone

causes allergic or photoallergic contact dermatitis; structure given in first source


Sodium Carbonate

used topically for dermatitides, mouthwash, vaginal douche; veterinary use as emergency emetic; RN given refers to carbonic acid, di-Na salt; structure


Hyperglycemic Hyperosmolar Nonketotic Coma


Diabetic ketoacidotic hyperglycemic coma


Silver Nitrate

A silver salt with powerful germicidal activity. It has been used topically to prevent OPHTHALMIA NEONATORUM.


Differential white blood cell count abnormal


Phencyclidine

A hallucinogen formerly used as a veterinary anesthetic, and briefly as a general anesthetic for humans. Phencyclidine is similar to KETAMINE in structure and in many of its effects. Like ketamine, it can produce a dissociative state. It exerts its pharmacological action through inhibition of NMDA receptors (RECEPTORS, N-METHYL-D-ASPARTATE). As a drug of abuse, it is known as PCP and Angel Dust.


Lysergide

Semisynthetic derivative of ergot (Claviceps purpurea). It has complex effects on serotonergic systems including antagonism at some peripheral serotonin receptors, both agonist and antagonist actions at central nervous system serotonin receptors, and possibly effects on serotonin turnover. It is a potent hallucinogen, but the mechanisms of that effect are not well understood.


Methandrostenolone

A synthetic steroid with anabolic properties that are more pronounced than its androgenic effects. It has little progestational activity. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1188)


Thimerosal

An ethylmercury-sulfidobenzoate that has been used as a preservative in VACCINES; ANTIVENINS; and OINTMENTS. It was formerly used as a topical antiseptic. It degrades to ethylmercury and thiosalicylate.


Titanium Dioxide

used medically as protectant against externally caused irritation & sunlight; high concentrations of dust may cause irritation to respiratory tract; RN given refers to titanium oxide (TiO2); structure


Tetrofosmin

Tetrofosmin is a diagnostic agent used to assess areas of reversible myocardial ischemia in the presence or absence of infracted myocardium and is also used to assess ventricular function.


Flunarizine

Flunarizine is a selective calcium entry blocker with calmodulin binding properties and histamine H1 blocking activity. It is effective in the prophylaxis of migraine, occlusive peripheral vascular disease, vertigo of central and peripheral origin, and as an adjuvant in the therapy of epilepsy.


Copper(II) oxide

see also Copper(I) oxide (cuprous oxide, Cu2O)


CITICOLINE

Donor of choline in biosynthesis of choline-containing phosphoglycerides.


Rulide

Semisynthetic derivative of erythromycin. It is concentrated by human phagocytes and is bioactive intracellularly. While the drug is active against a wide spectrum of pathogens, it is particularly effective in the treatment of respiratory and genital tract infections.


Brivudine

anti-herpes agent; (Z)-isomer much less active against herpes simplex virus type 1 & somewhat less active against herpes simplex virus type 2 than is the (E)-isomer; both isomers show similar activity against vaccinia virus; RN given refers to (E)-trans-isomer; structure


Prothipendyl

a neuroleptic azaphenothiazine; RN given refers to parent cpd


Eucalyptol

A monoterpene and cyclohexanol derivative that is the major component of EUCALYPTUS OIL. It is used in mouthwash, insect repellent, and as a cough suppressant, and also is widely used as a flavoring agent and solvent. It has antimicrobial properties.


Iobitridol

a nonionic monomeric low-osmolality contrast medium; structure given in second source


Betamethasone phosphate

phosphate ester of betamethasone; RN given refers to the di-Na salt (11beta,16beta)-isomer; structure in Negwer,5th ed, 4975


Propiverine

anticholinergic used for overactive bladder syndrome


Febrile seizure (within the age range of 3 months to 6 years)


gastric adenocarcinoma and proximal polyposis of the stomach


Hangover from any Alcohol or Other Drugs substance


Pyridoxal

The 4-carboxyaldehyde form of VITAMIN B 6 which is converted to PYRIDOXAL PHOSPHATE which is a coenzyme for synthesis of amino acids, neurotransmitters (serotonin, norepinephrine), sphingolipids, aminolevulinic acid.


monoclonal gammopathy of uncertain significance


Loss of hypoglycemic warning due to diabetes mellitus


Estriol

A hydroxylated metabolite of ESTRADIOL or ESTRONE that has a hydroxyl group at C3, 16-alpha, and 17-beta position. Estriol is a major urinary estrogen. During PREGNANCY, a large amount of estriol is produced by the PLACENTA. Isomers with inversion of the hydroxyl group or groups are called epiestriol.


INR - international normal ratio abnormal


congenital short bowel syndrome, autosomal recessive


Dequalinium

A topical bacteriostat that is available as various salts. It is used in wound dressings and mouth infections and may also have antifungal action, but may cause skin ulceration.


T-cell large granular lymphocyte leukemia


Lung carcinoma cell type unspecified stage I


Lung carcinoma cell type unspecified stage II


Stage III Lung Carcinoma Cell Type Unspecified


Mean cell hemoglobin concentration decreased


Mean cell hemoglobin concentration increased


Decreased mean corpuscular hemoglobin concentration


Cyproterone acetate

An agent with anti-androgen and progestational properties. It shows competitive binding with dihydrotestosterone at androgen receptor sites.


Secondary malignant neoplasm of adrenal gland


metastatic malignant neoplasm in the lymph nodes


Secondary malignant neoplasm of vertebral column


Secondary malignant neoplasm of mediastinum


bronchiolitis obliterans with obstructive pulmonary disease


CHORIONIC GONADOTROPIN

A gonadotropic glycoprotein hormone produced primarily by the PLACENTA. Similar to the pituitary LUTEINIZING HORMONE in structure and function, chorionic gonadotropin is involved in maintaining the CORPUS LUTEUM during pregnancy. CG consists of two noncovalently linked subunits, alpha and beta. Within a species, the alpha subunit is virtually identical to the alpha subunits of the three pituitary glycoprotein hormones (TSH, LH, and FSH), but the beta subunit is unique and confers its biological specificity (CHORIONIC GONADOTROPIN, BETA SUBUNIT, HUMAN).


Patent ductus arteriosus - persisting type


Piritramide

A diphenylpropylamine with intense narcotic analgesic activity of long duration. It is a derivative of MEPERIDINE with similar activity and usage.


Dihydralazine

1,4-Dihydrazinophthalazine. An antihypertensive agent with actions and uses similar to those of HYDRALAZINE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p354)


Platelet aggregation increased (finding)


inherited bleeding disorder, platelet-type


Pneumonia due to respiratory syncytial virus


Atosiban

Atosiban is a synthetic peptide which is a competitive antagonist of human oxytocin at receptor level. In human pre-term labour, atosiban at the recommended dosage antagonises uterine contractions and induces uterine quiescence.


Increased pulmonary capillary wedge pressure


myelodysplastic syndrome with excess blasts


Respiratory syncytial virus bronchiolitis


Paraldehyde

A hypnotic and sedative with anticonvulsant effects. However, because of the hazards associated with its administration, its tendency to react with plastic, and the risks associated with its deterioration, it has largely been superseded by other agents. It is still occasionally used to control status epilepticus resistant to conventional treatment. (From Martindale, The Extra Pharmacopoeia, 30th ed, p608-9)


5-HTP (5-Hydroxytryptophan) is a chemical by-product of the protein building block L-tryptophan. It is also produced commercially from the seeds of an African plant known as Griffonia simplicifolia 5-HTP is used for sleep disorders such as insomnia, depression, anxiety, migraine and tension-type headaches, fibromyalgia, obesity, premenstrual syndrome (PMS), premenstrual dysphoric disorder (PMDD), attention deficit-hyperactivity disorder (ADHD), seizure disorder, and Parkinson's disease.


Abnormal circulating ferritin concentration


Decreased circulating ferritin concentration


Increased circulating ferritin concentration


Sleep disorder due to general medical condition, insomnia type


temporomandibular joint dysfunction syndrome


Nabiximols

Compounds having the cannabinoid structure. They were originally extracted from Cannabis sativa L. The most pharmacologically active constituents are TETRAHYDROCANNABINOL; CANNABINOL; and CANNABIDIOL.


Amsacrine

An aminoacridine derivative that intercalates into DNA and is used as an antineoplastic agent.


idiopathic spontaneous coronary artery dissection


acute generalized exanthematous pustulosis


Premature closure of the ductus arteriosus


inborn mitochondrial metabolism disorder


Blood urea nitrogen/creatinine ratio increased


Anti-neutrophil cytoplasmic antibody positive vasculitis


hyper-IgE recurrent infection syndrome 1


Drug ineffective for unapproved indication


Electrocardiogram QRS Complex Shortened by ECG Finding


5-hydroxyindolacetic acid in urine increased


Secondary malignant neoplasm of chest wall


Secondary malignant neoplasm of peritoneum


Metastasis from malignant neoplasm of colon and/or rectum


Detachment of retinal pigment epithelium


Human immunodeficiency virus transmission


Protein/Creatinine ratio in urine above normal


Urine albumin/creatinine ratio increased


Thymalfasin

A thymus hormone polypeptide found in thymosin fraction 5 (a crude thymus gland extract) but now produced by synthesis. It is used alone or with interferon as an immunomodulator for the treatment of CHRONIC HEPATITIS B and HEPATITIS C. Thymalfasin is also used for the treatment of chemotherapy-induced immunosuppression, and to enhance the efficacy of influenza and hepatitis B vaccines in immunocompromised patients.


Increased viscosity of bronchial secretion


Anticonvulsant drug level above therapeutic


Neutropenia in presence of anti-neutropil antibodies


Free thyroxine concentration decreased below normal


Free thyroxine concentration increased above normal


Bilateral tonic-clonic seizure with focal onset


Anticonvulsant drug level below therapeutic


Infective exacerbation of chronic obstructive airways disease


Gastrointestinal tract mucosal discoloration


chronic inflammatory demyelinating polyradiculoneuropathy


Electrocardiogram signs of myocardial ischemia


Chronic lymphocytic leukemia transformation


Reactivation of hepatitis B viral hepatitis


Antipsychotic drug level above therapeutic


Antipsychotic drug level below therapeutic


Right ventricular systolic pressure increased


Anticoagulation drug level above therapeutic


Anticoagulation drug level below therapeutic


congenital anomaly of cardiovascular system


Abnormality on pulmonary function testing


Antidepressant drug level above therapeutic


Cardioactive drug level above therapeutic


Amrubicin

Amrubicin is a third-generation anthracycline and potent topoisomerase II inhibitor, for used in the treatment of small-cell lung cancer (SCLC) in Japan.


Extranodal marginal zone B-cell lymphoma (MALT type)


postural orthostatic tachycardia syndrome


Crouzon syndrome-acanthosis nigricans syndrome


International normalized ratio fluctuation


Gene mutation identification test positive


Hyperglycemic hyperosmolar nonketotic syndrome


Lower respiratory tract infection bacterial


Sleep disorder due to a general medical condition


Non-high-density lipoprotein cholesterol increased


Labeled drug-drug interaction medication error


Labeled drug-disease interaction medication error


Clodronic Acid

A diphosphonate which affects calcium metabolism. It inhibits bone resorption and soft tissue calcification.


immune reconstitution inflammatory syndrome


Lower respiratory tract infection fungal


Left ventricle outflow tract obstruction


Acute graft versus host disease in liver


Acute graft versus host disease in intestine


hematopoietic and lymphoid system neoplasm


Human herpesvirus 6 infection reactivation


myelodysplastic syndrome with multilineage dysplasia


Eastern Cooperative Oncology Group performance status worsened


Epstein-Barr virus-associated malignant lymphoproliferative disorder


Creatinine clearance-glomerular filtration abnormal


myelodysplastic syndrome associated with isolated del(5q)


Respiratory syncytial virus test positive


Anti-cyclic citrullinated peptide antibody positive


tubulointerstitial nephritis and uveitis syndrome


Iotalamic acid

A contrast medium in diagnostic radiology with properties similar to those of diatrizoic acid. It is used primarily as its sodium and meglumine (IOTHALAMATE MEGLUMINE) salts.


Bambuterol

selective inhibitor of butyrylcholinesterase & acetylcholinesterase


Infective exacerbation of bronchiectasis


Mycobacterium tuberculosis complex test positive


Infective pulmonary exacerbation of cystic fibrosis


Heparin-induced thrombocytopenia test positive


Intentional medical device removal by patient


Expanded disability status scale score increased


Dydrogesterone

A synthetic progestational hormone with no androgenic or estrogenic properties. Unlike many other progestational compounds, dydrogesterone produces no increase in temperature and does not inhibit OVULATION.


N-terminal prohormone brain natriuretic peptide abnormal


N-terminal prohormone brain natriuretic peptide increased


Chronic graft versus host disease in intestine


Chronic graft versus host disease in skin


Chronic graft versus host disease in liver


technetium Tc 99m mebrofenin

A radioconjugate composed of the iminodiacetic acid derivative mebrofenin bound to an isotope of the synthetic element technetium (Tc). Upon administration and rapid clearance from the circulation, technetium Tc 99m mebrofenin is secreted into the hepatobiliary system, emitting gamma rays that are detectable with planar scintigraphy or single photon emission computer tomography (SPECT). Mebrofenin has no pharmacological effect at the recommended dosage for diagnostic imagining.


steroid-responsive encephalopathy associated with autoimmune thyroiditis


Inadequate aseptic technique in use of product


Myelodysplastic syndrome with single lineage dysplasia


Immune reconstitution inflammatory syndrome associated tuberculosis


Central Nervous System Fungal Infections


Post-injection delirium sedation syndrome


preterm premature rupture of the membranes


Primary malignant neoplasm of unknown site


congenital isolated adrenocorticotropic hormone deficiency


reversible cerebral vasoconstriction syndrome


drug rash with eosinophilia and systemic symptoms


Therapeutic drug monitoring analysis not performed


Infection by Pneumocystis jirovecii (disorder)


Hypothalamic pituitary adrenal axis suppression


Parenteral nutrition associated liver disease


Ectopic pregnancy with contraceptive device


Fetal heart rate deceleration abnormality


Graft versus host disease in gastrointestinal tract


Disability assessment scale score increased


Drug monitoring procedure incorrectly performed


Unmasking of previously unidentified disease


Documented hypersensitivity to administered product


Enbucrilate

A tissue adhesive that is applied as a monomer to moist tissue and polymerizes to form a bond. It is slowly biodegradable and used in all kinds of surgery, including dental.


Wrong technique in product usage process


Unintentional use for unapproved indication


Prescription drug used without a prescription


Osteonecrosis of external auditory canal


Behavioral and psychological symptoms of dementia


Transformation to acute myeloid leukemia


Drug effective for unapproved indication


Loss of personal independence in daily activities


Pancreatitis due to pancreatic duct obstruction


Gastrointestinal vascular malformation hemorrhagic


Increased reactive oxygen species production


Product administered at inappropriate site


Incorrect route of product administration


Inappropriate schedule of product administration


Intercepted product administration error


Product administered to patient of inappropriate age


Incorrect product administration duration


Philadelphia positive chronic myeloid leukemia


Autoimmune inflammation of skeletal muscle


Post 5-alpha-reductase inhibitor syndrome


Undetermined manner of death, suicide suspected


New onset diabetes after transplantation


Chronic graft versus host disease in eye


Failure of child resistant product closure


Disseminated varicella zoster virus infection


KCNH2_HUMAN Potassium voltage-gated channel subfamily H member 2 (sprot)


SCN1A_HUMAN Sodium channel protein type 1 subunit alpha (sprot)


SCN4A_HUMAN Sodium channel protein type 4 subunit alpha (sprot)


PE2R1_HUMAN Prostaglandin E2 receptor EP1 subtype (sprot)


5HT3A_HUMAN 5-hydroxytryptamine receptor 3A (sprot)


KCND3_HUMAN Potassium voltage-gated channel subfamily D member 3 (sprot)


KCNA5_HUMAN Potassium voltage-gated channel subfamily A member 5 (sprot)


(S)-Nicardipine

S-enantiomer of nicardipine is a calcium entry blocker (slow channel blocker or calcium ion antagonist) which inhibits the transmembrane influx of calcium ions into cardiac muscle and smooth muscle without changing serum calcium concentrations


CAC1D_HUMAN Voltage-dependent L-type calcium channel subunit alpha-1D (sprot)


CAC1C_HUMAN Voltage-dependent L-type calcium channel subunit alpha-1C (sprot)


KCNN4_HUMAN Intermediate conductance calcium-activated potassium channel protein 4 (sprot)


CAC1F_HUMAN Voltage-dependent L-type calcium channel subunit alpha-1F (sprot)


CAC1C_RAT Voltage-dependent L-type calcium channel subunit alpha-1C (sprot)


CAC1S_RAT Voltage-dependent L-type calcium channel subunit alpha-1S (sprot)


Levdobutamine

Levdobutamine, an investigational drug, is a  beta-adrenoceptor agonist selective for the beta1-subtype. It is the cardiotonic agent.


ADRB1_HUMAN Beta-1 adrenergic receptor (sprot)


DYR_MOUSE Dihydrofolate reductase (sprot)


DYR_ECOLI Dihydrofolate reductase (sprot)


DYR_LACCA Dihydrofolate reductase (sprot)


B0BL08_ECOLX Dihydrofolate reductase (trembl)


FOLC_MOUSE Folylpolyglutamate synthase, mitochondrial (sprot)


DYR_HUMAN Dihydrofolate reductase (sprot)


ALDR_HUMAN Aldo-keto reductase family 1 member B1 (sprot)


HDAC2_HUMAN Histone deacetylase 2 (sprot)


HDAC1_HUMAN Histone deacetylase 1 (sprot)


HDAC8_HUMAN Histone deacetylase 8 (sprot)


DNMT1_HUMAN DNA (cytosine-5)-methyltransferase 1 (sprot)


DNM3A_HUMAN DNA (cytosine-5)-methyltransferase 3A (sprot)


MRP5_HUMAN ATP-binding cassette sub-family C member 5 (sprot)


MRP8_HUMAN ATP-binding cassette sub-family C member 11 (sprot)


UPP_ECOLI Uracil phosphoribosyltransferase (sprot)


Azaribine

pyrimidine analogue; anti-metabolite used in psoriasis & mycosis fungoides


PYRF_METTH Orotidine 5'-phosphate decarboxylase (sprot)


PYRF_YEAST Orotidine 5'-phosphate decarboxylase (sprot)


AOFA_HUMAN Amine oxidase [flavin-containing] A (sprot)


Q72547_9HIV1 Reverse transcriptase/RNaseH (Fragment) (trembl)


Q9WKE8_9HIV1 Reverse transcriptase (Fragment) (trembl)


GNRHR_HUMAN Gonadotropin-releasing hormone receptor (sprot)


GBRA1_HUMAN Gamma-aminobutyric acid receptor subunit alpha-1 (sprot)


GBRG2_HUMAN Gamma-aminobutyric acid receptor subunit gamma-2 (sprot)


GBRB3_HUMAN Gamma-aminobutyric acid receptor subunit beta-3 (sprot)


NMDE4_HUMAN Glutamate receptor ionotropic, NMDA 2D (sprot)


NMD3B_HUMAN Glutamate receptor ionotropic, NMDA 3B (sprot)


NMDZ1_HUMAN Glutamate receptor ionotropic, NMDA 1 (sprot)


NMDE1_HUMAN Glutamate receptor ionotropic, NMDA 2A (sprot)


NMDE2_HUMAN Glutamate receptor ionotropic, NMDA 2B (sprot)


NMDE3_HUMAN Glutamate receptor ionotropic, NMDA 2C (sprot)


NMD3A_HUMAN Glutamate receptor ionotropic, NMDA 3A (sprot)


AMYP_HUMAN Pancreatic alpha-amylase (sprot)


LYAG_HUMAN Lysosomal alpha-glucosidase (sprot)


SUIS_RAT Sucrase-isomaltase, intestinal (sprot)


LYAG_RAT Lysosomal alpha-glucosidase (sprot)


MALX3_YEAST Oligo-1,6-glucosidase IMA1 (sprot)


AMYP_PIG Pancreatic alpha-amylase (sprot)


SUIS_HUMAN Sucrase-isomaltase, intestinal (sprot)


ADRB2_HUMAN Beta-2 adrenergic receptor (sprot)


5HT1A_RAT 5-hydroxytryptamine receptor 1A (sprot)


ALDR_RAT Aldo-keto reductase family 1 member B1 (sprot)


MK01_HUMAN Mitogen-activated protein kinase 1 (sprot)


PGH2_HUMAN Prostaglandin G/H synthase 2 (sprot)


Acediasulfone

antibacterial drug for treatment of ear infections


ALDR_BOVIN Aldo-keto reductase family 1 member B1 (sprot)


A0A113T0T6_PLABE Hydroxymethyldihydropterin pyrophosphokinase-dihydropteroate synthase, putative (trembl)


PGH1_HUMAN Prostaglandin G/H synthase 1 (sprot)


LGUL_HUMAN Lactoylglutathione lyase (sprot)


VKOR1_RAT Vitamin K epoxide reductase complex subunit 1 (sprot)


VKOR1_HUMAN Vitamin K epoxide reductase complex subunit 1 (sprot)


AA2BR_HUMAN Adenosine receptor A2b (sprot)


HRH1_HUMAN Histamine H1 receptor (sprot)


TRPV1_HUMAN Transient receptor potential cation channel subfamily V member 1 (sprot)


NR1I3_HUMAN Nuclear receptor subfamily 1 group I member 3 (sprot)


CAH12_HUMAN Carbonic anhydrase 12 (sprot)


CAH14_HUMAN Carbonic anhydrase 14 (sprot)


AL5AP_HUMAN Arachidonate 5-lipoxygenase-activating protein (sprot)


LOX15_RABIT Polyunsaturated fatty acid lipoxygenase ALOX15 (sprot)


CAH13_MOUSE Carbonic anhydrase 13 (sprot)


CAH15_MOUSE Carbonic anhydrase 15 (sprot)


CNR1_HUMAN Cannabinoid receptor 1 (sprot)


Acetanilide

a phenylacetamide; use ACETANILIDES for the plural group meaning of the singular term


PNCB_HUMAN Nicotinate phosphoribosyltransferase (sprot)


Q9VTU8_DROME Carbonic anhydrase 2, isoform A (trembl)


Q9V396_DROME Carbonic anhydrase (trembl)


CAH5A_HUMAN Carbonic anhydrase 5A, mitochondrial (sprot)


CAH5B_HUMAN Carbonic anhydrase 5B, mitochondrial (sprot)


Q50565_METTH Carbonic anhydrase (trembl)


CAH13_HUMAN Carbonic anhydrase 13 (sprot)


P96878_MYCTU Carbonic anhydrase (trembl)


Q6FTL6_CANGA Carbonic anhydrase (trembl)


B5SU02_STYPI Carbonic anhydrase (trembl)


C0IX24_STYPI Carbonic anhydrase (trembl)


Q3I4V7_CRYNV Carbonic anhydrase (trembl)


Q2PCB5_DICLA Carbonic anhydrase (trembl)


A6YCJ1_9METZ Carbonic anhydrase (trembl)


MTCA1_MYCTU Beta-carbonic anhydrase 1 (sprot)


Q5U9J1_THAWE Delta carbonic anhydrase (trembl)


MTCA2_MYCTU Carbonic anhydrase 2 (sprot)


ACM3_HUMAN Muscarinic acetylcholine receptor M3 (sprot)


Q5TU56_ANOGA Carbonic anhydrase (trembl)


Q9HVB9_PSEAE Carbonic anhydrase (trembl)


Q31FD6_HYDCU Carbonic anhydrase, alpha family (trembl)


B2V8E3_SULSY Carbonic anhydrase (trembl)


CAH11_HUMAN Carbonic anhydrase-related protein 11 (sprot)


KCJ11_HUMAN ATP-sensitive inward rectifier potassium channel 11 (sprot)


ABCC8_HUMAN ATP-binding cassette sub-family C member 8 (sprot)


URE1_ECOLX Urease subunit alpha (Fragment) (sprot)


Q0PXQ5_HELPX Urease subunit beta (trembl)


DRD2_HUMAN D(2) dopamine receptor (sprot)


ACE_HUMAN Angiotensin-converting enzyme (sprot)


ACE_RABIT Angiotensin-converting enzyme (sprot)


ECE1_HUMAN Endothelin-converting enzyme 1 (sprot)


EST1_HUMAN Liver carboxylesterase 1 (sprot)


DHB1_HUMAN 17-beta-hydroxysteroid dehydrogenase type 1 (sprot)


DHB2_HUMAN 17-beta-hydroxysteroid dehydrogenase type 2 (sprot)


DHI2_HUMAN 11-beta-hydroxysteroid dehydrogenase type 2 (sprot)


DHI1_HUMAN 11-beta-hydroxysteroid dehydrogenase 1 (sprot)


ACM1_HUMAN Muscarinic acetylcholine receptor M1 (sprot)


ACM2_HUMAN Muscarinic acetylcholine receptor M2 (sprot)


ACM4_HUMAN Muscarinic acetylcholine receptor M4 (sprot)


ACM5_HUMAN Muscarinic acetylcholine receptor M5 (sprot)


ACHA7_HUMAN Neuronal acetylcholine receptor subunit alpha-7 (sprot)


ACHP_LYMST Acetylcholine-binding protein (sprot)


ACHD_TETCF Acetylcholine receptor subunit delta (sprot)


ACHA7_RAT Neuronal acetylcholine receptor subunit alpha-7 (sprot)


ACHA2_RAT Neuronal acetylcholine receptor subunit alpha-2 (sprot)


ACHB2_RAT Neuronal acetylcholine receptor subunit beta-2 (sprot)


ACHA3_RAT Neuronal acetylcholine receptor subunit alpha-3 (sprot)


ACHB4_RAT Neuronal acetylcholine receptor subunit beta-4 (sprot)


ACHA4_RAT Neuronal acetylcholine receptor subunit alpha-4 (sprot)


ACHB2_HUMAN Neuronal acetylcholine receptor subunit beta-2 (sprot)


ACHA4_HUMAN Neuronal acetylcholine receptor subunit alpha-4 (sprot)


ACM1_RAT Muscarinic acetylcholine receptor M1 (sprot)


ACM3_RAT Muscarinic acetylcholine receptor M3 (sprot)


ACM4_RAT Muscarinic acetylcholine receptor M4 (sprot)


ACM5_RAT Muscarinic acetylcholine receptor M5 (sprot)


ACM2_RAT Muscarinic acetylcholine receptor M2 (sprot)


H6TY12_PERAM Nicotinic acetylcholine receptor alpha8 subunit (trembl)


VEGFA_HUMAN Vascular endothelial growth factor A (sprot)


SODM_HUMAN Superoxide dismutase [Mn], mitochondrial (sprot)


GSHB_HUMAN Glutathione synthetase (sprot)


XCT_HUMAN Cystine/glutamate transporter (sprot)


AT1A1_HUMAN Sodium/potassium-transporting ATPase subunit alpha-1 (sprot)


AT1B1_HUMAN Sodium/potassium-transporting ATPase subunit beta-1 (sprot)


AT1A3_HUMAN Sodium/potassium-transporting ATPase subunit alpha-3 (sprot)


AT1B2_HUMAN Sodium/potassium-transporting ATPase subunit beta-2 (sprot)


AT1A2_HUMAN Sodium/potassium-transporting ATPase subunit alpha-2 (sprot)


AT1B3_HUMAN Sodium/potassium-transporting ATPase subunit beta-3 (sprot)


ATNG_HUMAN Sodium/potassium-transporting ATPase subunit gamma (sprot)


AT1A4_HUMAN Sodium/potassium-transporting ATPase subunit alpha-4 (sprot)


Acepromazine

Acepromazine, a phenothiazine derivatives, was first used in the 1950s in the treatment of PSYCHOSES. Now, it is commonly used as tranquilizer/sedative agent in dogs, cats, horses, and other animals. It is thought to block dopamine receptors in the brain or inhibit the activity of dopamine in other ways.


DRD1_HUMAN D(1A) dopamine receptor (sprot)


PA2A3_NAJSG Acidic phospholipase A2 3 (Fragment) (sprot)


GGT1_HUMAN Glutathione hydrolase 1 proenzyme (sprot)


PGH1_SHEEP Prostaglandin G/H synthase 1 (sprot)


PGH2_SHEEP Prostaglandin G/H synthase 2 (sprot)


PGH1_BOVIN Prostaglandin G/H synthase 1 (sprot)


ASIC3_HUMAN Acid-sensing ion channel 3 (sprot)


HCAR2_HUMAN Hydroxycarboxylic acid receptor 2 (sprot)


RARA_HUMAN Retinoic acid receptor alpha (sprot)


ABCBB_HUMAN Bile salt export pump (sprot)


RARG_HUMAN Retinoic acid receptor gamma (sprot)


5HT2B_HUMAN 5-hydroxytryptamine receptor 2B (sprot)


MMP2_HUMAN 72 kDa type IV collagenase (sprot)


TOP2A_HUMAN DNA topoisomerase 2-alpha (sprot)


TOP2B_HUMAN DNA topoisomerase 2-beta (sprot)


MDR1_HUMAN ATP-dependent translocase ABCB1 (sprot)


HRH1_CAVPO Histamine H1 receptor (sprot)


PNPH_HUMAN Purine nucleoside phosphorylase (sprot)


PUNA_MYCTU Purine nucleoside phosphorylase (sprot)


DPOL_HHV11 DNA polymerase catalytic subunit (sprot)


DPOL_VZVD DNA polymerase catalytic subunit (sprot)


GLRA1_HUMAN Glycine receptor subunit alpha-1 (sprot)


RARB_HUMAN Retinoic acid receptor beta (sprot)


DPOG1_HUMAN DNA polymerase subunit gamma-1 (sprot)


Adenine

A purine base and a fundamental unit of ADENINE NUCLEOTIDES.


XDH_HUMAN Xanthine dehydrogenase/oxidase (sprot)


PI4KB_HUMAN Phosphatidylinositol 4-kinase beta (sprot)


P4K2A_HUMAN Phosphatidylinositol 4-kinase type 2-alpha (sprot)


P4K2B_HUMAN Phosphatidylinositol 4-kinase type 2-beta (sprot)


PI4KA_HUMAN Phosphatidylinositol 4-kinase alpha (sprot)


AA2AR_HUMAN Adenosine receptor A2a (sprot)


AA1R_HUMAN Adenosine receptor A1 (sprot)


AA3R_HUMAN Adenosine receptor A3 (sprot)


AA2AR_RAT Adenosine receptor A2a (sprot)


M3K7_HUMAN Mitogen-activated protein kinase kinase kinase 7 (sprot)


AA2BR_RAT Adenosine receptor A2b (sprot)


G3P_HUMAN Glyceraldehyde-3-phosphate dehydrogenase (sprot)


KAPCA_BOVIN cAMP-dependent protein kinase catalytic subunit alpha (sprot)


KAP2_BOVIN cAMP-dependent protein kinase type II-alpha regulatory subunit (sprot)


KAPCB_BOVIN cAMP-dependent protein kinase catalytic subunit beta (sprot)


KAP3_BOVIN cAMP-dependent protein kinase type II-beta regulatory subunit (sprot)


DOT1L_HUMAN Histone-lysine N-methyltransferase, H3 lysine-79 specific (sprot)


JAK2_HUMAN Tyrosine-protein kinase JAK2 (sprot)


TRPM4_HUMAN Transient receptor potential cation channel subfamily M member 4 (sprot)


MAPK2_HUMAN MAP kinase-activated protein kinase 2 (sprot)


GPR17_HUMAN Uracil nucleotide/cysteinyl leukotriene receptor (sprot)


TRAP1_HUMAN Heat shock protein 75 kDa, mitochondrial (sprot)


KAD2_RAT Adenylate kinase 2, mitochondrial (sprot)


HSP7C_HUMAN Heat shock cognate 71 kDa protein (sprot)


HS71A_HUMAN Heat shock 70 kDa protein 1A (sprot)


TRPM4_MOUSE Transient receptor potential cation channel subfamily M member 4 (sprot)


F16P1_HUMAN Fructose-1,6-bisphosphatase 1 (sprot)


F16P1_PIG Fructose-1,6-bisphosphatase 1 (sprot)


SRC_HUMAN Proto-oncogene tyrosine-protein kinase Src (sprot)


TRPM2_HUMAN Transient receptor potential cation channel subfamily M member 2 (sprot)


Q72874_9HIV1 Pol polyprotein (Fragment) (trembl)


ADH1E_HORSE Alcohol dehydrogenase E chain (sprot)


ADH1S_HORSE Alcohol dehydrogenase S chain (sprot)


LDHA_HUMAN L-lactate dehydrogenase A chain (sprot)


PANE_ECOLI 2-dehydropantoate 2-reductase (sprot)


DNPH1_HUMAN 2'-deoxynucleoside 5'-phosphate N-hydrolase 1 (sprot)


DNPH1_RAT 2'-deoxynucleoside 5'-phosphate N-hydrolase 1 (sprot)


GBRD_HUMAN Gamma-aminobutyric acid receptor subunit delta (sprot)


GBRB1_HUMAN Gamma-aminobutyric acid receptor subunit beta-1 (sprot)


GBRA5_HUMAN Gamma-aminobutyric acid receptor subunit alpha-5 (sprot)


GBRA3_HUMAN Gamma-aminobutyric acid receptor subunit alpha-3 (sprot)


GBRA2_HUMAN Gamma-aminobutyric acid receptor subunit alpha-2 (sprot)


GBRB2_HUMAN Gamma-aminobutyric acid receptor subunit beta-2 (sprot)


GBRA4_HUMAN Gamma-aminobutyric acid receptor subunit alpha-4 (sprot)


GBRA6_HUMAN Gamma-aminobutyric acid receptor subunit alpha-6 (sprot)


GBRG1_HUMAN Gamma-aminobutyric acid receptor subunit gamma-1 (sprot)


GBRG3_HUMAN Gamma-aminobutyric acid receptor subunit gamma-3 (sprot)


5HT2A_HUMAN 5-hydroxytryptamine receptor 2A (sprot)


MTR1A_HUMAN Melatonin receptor type 1A (sprot)


MTR1B_HUMAN Melatonin receptor type 1B (sprot)


MTR1A_CHICK Melatonin receptor type 1A (sprot)


MTR1C_CHICK Melatonin receptor type 1C (sprot)


MTR1B_CHICK Melatonin receptor type 1B (Fragment) (sprot)


5HT2C_HUMAN 5-hydroxytryptamine receptor 2C (sprot)


SCN5A_HUMAN Sodium channel protein type 5 subunit alpha (sprot)


PARC_ECOLI DNA topoisomerase 4 subunit A (sprot)


PARE_ECOLI DNA topoisomerase 4 subunit B (sprot)


C4PKZ2_ECHGR Tubulin beta chain (Fragment) (trembl)


C4PKZ6_ECHGR Beta-tubulin isoform 3 (Fragment) (trembl)


C4PKY4_ECHGR Beta-tubulin isoform 1 (Fragment) (trembl)


F1L005_ASCSU Tubulin alpha chain (trembl)


F1L4P8_ASCSU Tubulin beta chain (Fragment) (trembl)


F1L5G6_ASCSU Tubulin alpha chain (Fragment) (trembl)


F1L7U3_ASCSU Tubulin beta chain (Fragment) (trembl)


F1L7Y0_ASCSU Tubulin alpha chain (Fragment) (trembl)


F1L8A5_ASCSU Tubulin beta chain (Fragment) (trembl)


F1LCS0_ASCSU Tubulin alpha-3 chain (trembl)


Albendazole oxide

Albendazole oxide (also known as albendazole sulphoxide and ricobendazole) is a benzimidazole with a broad-spectrum anthelmintic used in veterinary medicine. It is also a metabolite of two other veterinary drugs: netobimin and albendazole. The mechanism of action of ricobendazole (albendazole sulfoxide), ensuring its anthelmintic activity, is associated with selective inhibition of beta-tubulin polymerization. It binds to the colchicine site of tubulin, inhibiting microtubule polymerization. It also exhibits anticancer activity, potentiating the effects of taxanes and inhibiting cell proliferation in breast cancer cells, non-small cell lung cancer (NSCLC) cells, and melanoma cells. Also, albendazole oxide has been shown to induce apoptosis in human cancer cell line HT-29, possibly by arresting the cell cycle at the G2/M phase.


ADRB2_CAVPO Beta-2 adrenergic receptor (sprot)


ADRB2_BOVIN Beta-2 adrenergic receptor (sprot)


A non-depolarizing skeletal muscle relaxant similar to TUBOCURARINE. It is used as an anesthesia adjuvant, for endotracheal intubation and to produce muscle relaxation in general anesthesia during surgical procedures.


ACHA2_HUMAN Neuronal acetylcholine receptor subunit alpha-2 (sprot)


ACM2_PIG Muscarinic acetylcholine receptor M2 (sprot)


ACHA_HUMAN Acetylcholine receptor subunit alpha (sprot)


ACHB_HUMAN Acetylcholine receptor subunit beta (sprot)


ACHD_HUMAN Acetylcholine receptor subunit delta (sprot)


ACHB4_HUMAN Neuronal acetylcholine receptor subunit beta-4 (sprot)


Aldosterone

A hormone secreted by the ADRENAL CORTEX that regulates electrolyte and water balance by increasing the renal retention of sodium and the excretion of potassium.


MCR_HUMAN Mineralocorticoid receptor (sprot)


CBG_HUMAN Corticosteroid-binding globulin (sprot)


SHBG_HUMAN Sex hormone-binding globulin (sprot)


MCR_RAT Mineralocorticoid receptor (sprot)


FPPS_HUMAN Farnesyl pyrophosphate synthase (sprot)


Q0GKD7_LEIDO Farnesyl pyrophosphate synthase (trembl)


FNTB_HUMAN Protein farnesyltransferase subunit beta (sprot)


FPPS_RAT Farnesyl pyrophosphate synthase (sprot)


IDI1_RAT Isopentenyl-diphosphate Delta-isomerase 1 (sprot)


FPPS_MOUSE Farnesyl pyrophosphate synthase (sprot)


Q4QBL1_LEIMA Farnesyl pyrophosphate synthase (trembl)


Alprenolol

One of the ADRENERGIC BETA-ANTAGONISTS used as an antihypertensive, anti-anginal, and anti-arrhythmic agent.


5HT1A_HUMAN 5-hydroxytryptamine receptor 1A (sprot)


Alexidine

until June 1975 was mistakenly treated as synonym for chlorhexidine; RN given refers to parent cpd


R1AB_SARS Replicase polyprotein 1ab (sprot)


PTPM1_HUMAN Phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1 (sprot)


OPRM_HUMAN Mu-type opioid receptor (sprot)


OPRM_RAT Mu-type opioid receptor (sprot)


OPRM_CAVPO Mu-type opioid receptor (Fragment) (sprot)


OPRD_RAT Delta-type opioid receptor (sprot)


OPRK_RAT Kappa-type opioid receptor (sprot)


SGMR1_RAT Sigma non-opioid intracellular receptor 1 (sprot)


ADA1A_HUMAN Alpha-1A adrenergic receptor (sprot)


ADA1D_HUMAN Alpha-1D adrenergic receptor (sprot)


ADA1B_HUMAN Alpha-1B adrenergic receptor (sprot)


S22A1_HUMAN Solute carrier family 22 member 1 (sprot)


ADA1D_RAT Alpha-1D adrenergic receptor (sprot)


ADA1A_BOVIN Alpha-1A adrenergic receptor (sprot)


Q9YQ12_9HIV1 Protease (Fragment) (trembl)


ADA2C_HUMAN Alpha-2C adrenergic receptor (sprot)


HPRT_HUMAN Hypoxanthine-guanine phosphoribosyltransferase (sprot)


XDH_BOVIN Xanthine dehydrogenase/oxidase (sprot)


XDH_RAT Xanthine dehydrogenase/oxidase (sprot)


STXA_SHIDY Shiga toxin subunit A (sprot)


5HT1B_HUMAN 5-hydroxytryptamine receptor 1B (sprot)


5HT1D_HUMAN 5-hydroxytryptamine receptor 1D (sprot)


5HT1F_HUMAN 5-hydroxytryptamine receptor 1F (sprot)


SC6A2_HUMAN Sodium-dependent noradrenaline transporter (sprot)


SC6A1_HUMAN Sodium- and chloride-dependent GABA transporter 1 (sprot)


GBRP_RAT Gamma-aminobutyric acid receptor subunit pi (sprot)


GBRB1_RAT Gamma-aminobutyric acid receptor subunit beta-1 (sprot)


GBRD_RAT Gamma-aminobutyric acid receptor subunit delta (sprot)


GBRG2_RAT Gamma-aminobutyric acid receptor subunit gamma-2 (sprot)


GBRA5_RAT Gamma-aminobutyric acid receptor subunit alpha-5 (sprot)


GBRA3_RAT Gamma-aminobutyric acid receptor subunit alpha-3 (sprot)


GBRG1_RAT Gamma-aminobutyric acid receptor subunit gamma-1 (sprot)


GBRA2_RAT Gamma-aminobutyric acid receptor subunit alpha-2 (sprot)


GBRA4_RAT Gamma-aminobutyric acid receptor subunit alpha-4 (sprot)


GBRG3_RAT Gamma-aminobutyric acid receptor subunit gamma-3 (sprot)


GBRA6_RAT Gamma-aminobutyric acid receptor subunit alpha-6 (sprot)


GBRA1_RAT Gamma-aminobutyric acid receptor subunit alpha-1 (sprot)


GBRB3_RAT Gamma-aminobutyric acid receptor subunit beta-3 (sprot)


GBRB2_RAT Gamma-aminobutyric acid receptor subunit beta-2 (sprot)


GBRE_RAT Gamma-aminobutyric acid receptor subunit epsilon (sprot)


PTAFR_HUMAN Platelet-activating factor receptor (sprot)


CCKAR_RAT Cholecystokinin receptor type A (sprot)


BRD4_HUMAN Bromodomain-containing protein 4 (sprot)


ADRB3_HUMAN Beta-3 adrenergic receptor (sprot)


PE2R3_HUMAN Prostaglandin E2 receptor EP3 subtype (sprot)


PI2R_HUMAN Prostacyclin receptor (sprot)


PE2R2_HUMAN Prostaglandin E2 receptor EP2 subtype (sprot)


PE2R4_HUMAN Prostaglandin E2 receptor EP4 subtype (sprot)


PD2R_HUMAN Prostaglandin D2 receptor (sprot)


PE2R1_MOUSE Prostaglandin E2 receptor EP1 subtype (sprot)


PE2R2_MOUSE Prostaglandin E2 receptor EP2 subtype (sprot)


PE2R3_MOUSE Prostaglandin E2 receptor EP3 subtype (sprot)


PE2R4_MOUSE Prostaglandin E2 receptor EP4 subtype (sprot)


PE2R2_RAT Prostaglandin E2 receptor EP2 subtype (sprot)


PE2R4_RAT Prostaglandin E2 receptor EP4 subtype (sprot)


CTSR1_HUMAN Cation channel sperm-associated protein 1 (sprot)


CTSR2_HUMAN Cation channel sperm-associated protein 2 (sprot)


CTSR3_HUMAN Cation channel sperm-associated protein 3 (sprot)


CTSR4_HUMAN Cation channel sperm-associated protein 4 (sprot)


PI2R_MOUSE Prostacyclin receptor (sprot)


PE2R3_RAT Prostaglandin E2 receptor EP3 subtype (sprot)


PE2R1_RAT Prostaglandin E2 receptor EP1 subtype (sprot)


OPRK_HUMAN Kappa-type opioid receptor (sprot)


OPRD_HUMAN Delta-type opioid receptor (sprot)


OPRK_CAVPO Kappa-type opioid receptor (sprot)


SGMR1_HUMAN Sigma non-opioid intracellular receptor 1 (sprot)


S47A1_HUMAN Multidrug and toxin extrusion protein 1 (sprot)


Q9W6Q1_9SALA Sodium/hydrogen exchanger (trembl)


SL9A5_HUMAN Sodium/hydrogen exchanger 5 (sprot)


Q20MD5_I72A8 Matrix protein 2 (Fragment) (trembl)


SC6A4_HUMAN Sodium-dependent serotonin transporter (sprot)


SCNAA_HUMAN Sodium channel protein type 10 subunit alpha (sprot)


GBA1_HUMAN Lysosomal acid glucosylceramidase (sprot)


GCR_HUMAN Glucocorticoid receptor (sprot)


ADA2B_RAT Alpha-2B adrenergic receptor (sprot)


ADA2C_RAT Alpha-2C adrenergic receptor (sprot)


ADA2A_RAT Alpha-2A adrenergic receptor (sprot)


ADA1B_RAT Alpha-1B adrenergic receptor (sprot)


ADA1A_RAT Alpha-1A adrenergic receptor (sprot)


DRD3_HUMAN D(3) dopamine receptor (sprot)


PPBT_HUMAN Alkaline phosphatase, tissue-nonspecific isozyme (sprot)


O32553_ECOLX Macrolide 2'-phosphotransferase II (trembl)


SCNNA_HUMAN Amiloride-sensitive sodium channel subunit alpha (sprot)


UROK_HUMAN Urokinase-type plasminogen activator (sprot)


SL9A1_HUMAN Sodium/hydrogen exchanger 1 (sprot)


ASIC2_HUMAN Acid-sensing ion channel 2 (sprot)


ASIC1_HUMAN Acid-sensing ion channel 1 (sprot)


AOC3_RAT Membrane primary amine oxidase (sprot)


SCNNB_HUMAN Amiloride-sensitive sodium channel subunit beta (sprot)


SCNNG_HUMAN Amiloride-sensitive sodium channel subunit gamma (sprot)


SL9A1_RAT Sodium/hydrogen exchanger 1 (sprot)


SL9A2_RABIT Sodium/hydrogen exchanger 2 (sprot)


UROK_MOUSE Urokinase-type plasminogen activator (sprot)


ASIC1_RAT Acid-sensing ion channel 1 (sprot)


NQO2_HUMAN Ribosyldihydronicotinamide dehydrogenase [quinone] (sprot)


TYTR_TRYCR Trypanothione reductase (sprot)


SC6A3_RAT Sodium-dependent dopamine transporter (sprot)


TPA_HUMAN Tissue-type plasminogen activator (sprot)


THAS_HUMAN Thromboxane-A synthase (sprot)


CP11A_HUMAN Cholesterol side-chain cleavage enzyme, mitochondrial (sprot)


CP11A_BOVIN Cholesterol side-chain cleavage enzyme, mitochondrial (sprot)


S22A6_HUMAN Solute carrier family 22 member 6 (sprot)


S22A6_MOUSE Solute carrier family 22 member 6 (sprot)


Aminopyrine

A pyrazolone with analgesic, anti-inflammatory, and antipyretic properties but has risk of AGRANULOCYTOSIS. A breath test with 13C-labeled aminopyrine has been used as a non-invasive measure of CYTOCHROME P-450 metabolic activity in LIVER FUNCTION TESTS.


NOS2_HUMAN Nitric oxide synthase, inducible (sprot)


MMP9_HUMAN Matrix metalloproteinase-9 (sprot)


MMP1_HUMAN Interstitial collagenase (sprot)


ADA2A_HUMAN Alpha-2A adrenergic receptor (sprot)


THA_HUMAN Thyroid hormone receptor alpha (sprot)


THB_HUMAN Thyroid hormone receptor beta (sprot)


BKRB2_HUMAN B2 bradykinin receptor (sprot)


5HT6R_HUMAN 5-hydroxytryptamine receptor 6 (sprot)


ADA2B_HUMAN Alpha-2B adrenergic receptor (sprot)


HRH2_HUMAN Histamine H2 receptor (sprot)


SC6A3_HUMAN Sodium-dependent dopamine transporter (sprot)


DRD4_HUMAN D(4) dopamine receptor (sprot)


CAC1H_HUMAN Voltage-dependent T-type calcium channel subunit alpha-1H (sprot)


EDNRA_HUMAN Endothelin-1 receptor (sprot)


ERG1_HUMAN Squalene monooxygenase (sprot)


FYN_HUMAN Tyrosine-protein kinase Fyn (sprot)


ERBB2_HUMAN Receptor tyrosine-protein kinase erbB-2 (sprot)


CCR2_HUMAN C-C chemokine receptor type 2 (sprot)


HCN4_HUMAN Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 (sprot)


KCNA7_HUMAN Potassium voltage-gated channel subfamily A member 7 (sprot)


5HT1B_RAT 5-hydroxytryptamine receptor 1B (sprot)


MC4R_HUMAN Melanocortin receptor 4 (sprot)


MC5R_HUMAN Melanocortin receptor 5 (sprot)


MC3R_HUMAN Melanocortin receptor 3 (sprot)


CCR4_HUMAN C-C chemokine receptor type 4 (sprot)


PGRC1_RAT Membrane-associated progesterone receptor component 1 (sprot)


ERG2_YEAST C-8 sterol isomerase ERG2 (sprot)


THAP1_HUMAN THAP domain-containing protein 1 (sprot)


SCN5A_RAT Sodium channel protein type 5 subunit alpha (sprot)


PHF2_HUMAN Lysine-specific demethylase PHF2 (sprot)


KDM5A_HUMAN Lysine-specific demethylase 5A (sprot)


KDM7A_HUMAN Lysine-specific demethylase 7A (sprot)


5HT7R_HUMAN 5-hydroxytryptamine receptor 7 (sprot)


DRD5_HUMAN D(1B) dopamine receptor (sprot)


HRH4_HUMAN Histamine H4 receptor (sprot)


SCN2A_HUMAN Sodium channel protein type 2 subunit alpha (sprot)


SCN9A_HUMAN Sodium channel protein type 9 subunit alpha (sprot)


RET_HUMAN Proto-oncogene tyrosine-protein kinase receptor Ret (sprot)


NTRK1_HUMAN High affinity nerve growth factor receptor (sprot)


SC6A4_RAT Sodium-dependent serotonin transporter (sprot)


5HT2A_RAT 5-hydroxytryptamine receptor 2A (sprot)


5HT7R_RAT 5-hydroxytryptamine receptor 7 (sprot)


5HT7R_MOUSE 5-hydroxytryptamine receptor 7 (sprot)


5HT2C_RAT 5-hydroxytryptamine receptor 2C (sprot)


5HT6R_RAT 5-hydroxytryptamine receptor 6 (sprot)


S22A2_HUMAN Solute carrier family 22 member 2 (sprot)


KCNJ6_MOUSE G protein-activated inward rectifier potassium channel 2 (sprot)


IKKE_HUMAN Inhibitor of nuclear factor kappa-B kinase subunit epsilon (sprot)


TBK1_HUMAN Serine/threonine-protein kinase TBK1 (sprot)


GPR35_HUMAN G-protein coupled receptor 35 (sprot)


PDE4A_HUMAN cAMP-specific 3',5'-cyclic phosphodiesterase 4A (sprot)


PDE4B_HUMAN cAMP-specific 3',5'-cyclic phosphodiesterase 4B (sprot)


PDE4C_HUMAN cAMP-specific 3',5'-cyclic phosphodiesterase 4C (sprot)


PDE4D_HUMAN cAMP-specific 3',5'-cyclic phosphodiesterase 4D (sprot)


CCG1_HUMAN Voltage-dependent calcium channel gamma-1 subunit (sprot)


CA2D1_HUMAN Voltage-dependent calcium channel subunit alpha-2/delta-1 (sprot)


KCNK2_HUMAN Potassium channel subfamily K member 2 (sprot)


Q8HY88_BOVIN Potassium channel subfamily K member 2 (trembl)


Amodiaquine

A 4-aminoquinoline compound with anti-inflammatory properties.


HNMT_HUMAN Histamine N-methyltransferase (sprot)


A4_HUMAN Amyloid-beta precursor protein (sprot)


SC6A5_HUMAN Sodium- and chloride-dependent glycine transporter 2 (sprot)


PBPA_CLOPE Penicillin-binding protein 1A (sprot)


PBPA_ECOLI Penicillin-binding protein 1A (sprot)


PBPB_ECOLI Penicillin-binding protein 1B (sprot)


DACC_ECOLI D-alanyl-D-alanine carboxypeptidase DacC (sprot)


MRDA_ECOLI Peptidoglycan D,D-transpeptidase MrdA (sprot)


FTSI_ECOLI Peptidoglycan D,D-transpeptidase FtsI (sprot)


DACA_ECOLI D-alanyl-D-alanine carboxypeptidase DacA (sprot)


DACB_ECOLI D-alanyl-D-alanine carboxypeptidase DacB (sprot)


FAAH1_HUMAN Fatty-acid amide hydrolase 1 (sprot)


CART_HUMAN Cocaine- and amphetamine-regulated transcript protein (sprot)


AOFA_RAT Amine oxidase [flavin-containing] A (sprot)


SC6A2_MOUSE Sodium-dependent noradrenaline transporter (sprot)


5HT2B_RAT 5-hydroxytryptamine receptor 2B (sprot)


SC6A4_MOUSE Sodium-dependent serotonin transporter (sprot)


5HT1D_RAT 5-hydroxytryptamine receptor 1D (sprot)


5HT1F_RAT 5-hydroxytryptamine receptor 1F (sprot)


5HT5A_RAT 5-hydroxytryptamine receptor 5A (sprot)


5HT5B_RAT 5-hydroxytryptamine receptor 5B (sprot)


5HT3A_RAT 5-hydroxytryptamine receptor 3A (sprot)


5HT4R_RAT 5-hydroxytryptamine receptor 4 (sprot)


5HT3B_RAT 5-hydroxytryptamine receptor 3B (sprot)


TAAR1_HUMAN Trace amine-associated receptor 1 (sprot)


TIE2_HUMAN Angiopoietin-1 receptor (sprot)


O90781_9PLVG HIV-1 protease (Fragment) (trembl)


Q9YQ30_9PLVG HIV-1 protease (Fragment) (trembl)


PDE3A_HUMAN cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A (sprot)


TTK_HUMAN Dual specificity protein kinase TTK (sprot)


PDE3B_HUMAN cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B (sprot)


TOP1M_HUMAN DNA topoisomerase I, mitochondrial (sprot)


PDE2A_HUMAN cGMP-dependent 3',5'-cyclic phosphodiesterase (sprot)


Androstenediol

An intermediate in TESTOSTERONE biosynthesis, found in the TESTIS or the ADRENAL GLANDS. Androstenediol, derived from DEHYDROEPIANDROSTERONE by the reduction of the 17-keto group (17-HYDROXYSTEROID DEHYDROGENASES), is converted to TESTOSTERONE by the oxidation of the 3-beta hydroxyl group to a 3-keto group (3-HYDROXYSTEROID DEHYDROGENASES).


ESR2_HUMAN Estrogen receptor beta (sprot)


Androstenedione

A delta-4 C19 steroid that is produced not only in the TESTIS, but also in the OVARY and the ADRENAL CORTEX. Depending on the tissue type, androstenedione can serve as a precursor to TESTOSTERONE as well as ESTRONE and ESTRADIOL.


DHB3_HUMAN 17-beta-hydroxysteroid dehydrogenase type 3 (sprot)


DHB3_RAT 17-beta-hydroxysteroid dehydrogenase type 3 (sprot)


PAI1_HUMAN Plasminogen activator inhibitor 1 (sprot)


MRP2_HUMAN ATP-binding cassette sub-family C member 2 (sprot)


MRP1_HUMAN Multidrug resistance-associated protein 1 (sprot)


MRP7_HUMAN ATP-binding cassette sub-family C member 10 (sprot)


TBB4B_HUMAN Tubulin beta-4B chain (sprot)


Anileridine

minor descriptor (64-86); on line & INDEX MEDICUS search ISONIPECOTIC ACIDS (68-86); RN given refers to parent cpd


Anisindione

a synthetic anticoagulant it exercises its therapeutic action by reducing the prothrombin activity of the blood by inhibiting the vitamin K–mediated gamma-carboxylation of precursor proteins


VKGC_HUMAN Vitamin K-dependent gamma-carboxylase (sprot)


LOX5_RAT Polyunsaturated fatty acid 5-lipoxygenase (sprot)


LX12B_HUMAN Arachidonate 12-lipoxygenase, 12R-type (sprot)


Q9BEG3_BOVIN 5-lipoxygenase (Fragment) (trembl)


SIR5_HUMAN NAD-dependent protein deacylase sirtuin-5, mitochondrial (sprot)


HEPS_HUMAN Serine protease hepsin (sprot)


TRPA1_HUMAN Transient receptor potential cation channel subfamily A member 1 (sprot)


DRD1_RAT D(1A) dopamine receptor (sprot)


DRD2_BOVIN D(2) dopamine receptor (sprot)


DRD1_MOUSE D(1A) dopamine receptor (sprot)


MEX5_CAEEL Zinc finger protein mex-5 (sprot)


G4VFD7_SCHMA Dihydroorotate dehydrogenase (quinone), mitochondrial (trembl)


DRD1_BOVIN D(1A) dopamine receptor (sprot)


DRD5_RAT D(1B) dopamine receptor (sprot)


MPI_HUMAN Mannose-6-phosphate isomerase (sprot)


G5EF15_CAEEL Cytoplasmic zinc-finger protein (trembl)


MDM2_HUMAN E3 ubiquitin-protein ligase Mdm2 (sprot)


NK3R_HUMAN Neuromedin-K receptor (sprot)


PSA1_HUMAN Proteasome subunit alpha type-1 (sprot)


NAC1_HUMAN Sodium/calcium exchanger 1 (sprot)


5HT5A_HUMAN 5-hydroxytryptamine receptor 5A (sprot)


5HT1E_HUMAN 5-hydroxytryptamine receptor 1E (sprot)


TRXR1_HUMAN Thioredoxin reductase 1, cytoplasmic (sprot)


S28A1_HUMAN Sodium/nucleoside cotransporter 1 (sprot)


ABCG2_HUMAN Broad substrate specificity ATP-binding cassette transporter ABCG2 (sprot)


SSR5_HUMAN Somatostatin receptor type 5 (sprot)


EGFR_HUMAN Epidermal growth factor receptor (sprot)


LCK_HUMAN Tyrosine-protein kinase Lck (sprot)


KCNH1_HUMAN Potassium voltage-gated channel subfamily H member 1 (sprot)


FNTA_BOVIN Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha (sprot)


FNTB_BOVIN Protein farnesyltransferase subunit beta (sprot)


HLAA_HUMAN HLA class I histocompatibility antigen, A alpha chain (sprot)


SGMR2_HUMAN Sigma intracellular receptor 2 (sprot)


NR4A2_HUMAN Nuclear receptor subfamily 4 group A member 2 (sprot)


Asulacrine

derivative of amsacrine; structure given in first source


UD11_HUMAN UDP-glucuronosyltransferase 1A1 (sprot)


B0FL73_CAVPO Beta-1 adrenergic receptor (trembl)


GABR2_RAT Gamma-aminobutyric acid type B receptor subunit 2 (sprot)


GABR1_RAT Gamma-aminobutyric acid type B receptor subunit 1 (sprot)


GABR2_HUMAN Gamma-aminobutyric acid type B receptor subunit 2 (sprot)


GABR1_HUMAN Gamma-aminobutyric acid type B receptor subunit 1 (sprot)


LOX5_HUMAN Polyunsaturated fatty acid 5-lipoxygenase (sprot)


PPARG_HUMAN Peroxisome proliferator-activated receptor gamma (sprot)


Q690N0_BOVIN Progesterone receptor (Fragment) (trembl)


AGRG3_HUMAN Adhesion G protein-coupled receptor G3 (sprot)


PRGR_HUMAN Progesterone receptor (sprot)


IL5RA_MOUSE Interleukin-5 receptor subunit alpha (sprot)


ACE_RAT Angiotensin-converting enzyme (sprot)


HDAC3_HUMAN Histone deacetylase 3 (sprot)


HDAC6_HUMAN Histone deacetylase 6 (sprot)


HDA10_HUMAN Polyamine deacetylase HDAC10 (sprot)


S12A3_HUMAN Solute carrier family 12 member 3 (sprot)


KCMA1_HUMAN Calcium-activated potassium channel subunit alpha-1 (sprot)


SCN3A_HUMAN Sodium channel protein type 3 subunit alpha (sprot)


Benserazide

An inhibitor of DOPA DECARBOXYLASE that does not enter the central nervous system. It is often given with LEVODOPA in the treatment of parkinsonism to prevent the conversion of levodopa to dopamine in the periphery, thereby increasing the amount that reaches the central nervous system and reducing the required dose. It has no antiparkinson actions when given alone.


DDC_HUMAN Aromatic-L-amino-acid decarboxylase (sprot)


SAE1_HUMAN SUMO-activating enzyme subunit 1 (sprot)


SAE2_HUMAN SUMO-activating enzyme subunit 2 (sprot)


S22AC_HUMAN Solute carrier family 22 member 12 (sprot)


EYA3_HUMAN Eyes absent homolog 3 (sprot)


EYA3_MOUSE Eyes absent homolog 3 (sprot)


AK1C1_HUMAN Aldo-keto reductase family 1 member C1 (sprot)


PTN1_HUMAN Tyrosine-protein phosphatase non-receptor type 1 (sprot)


MK14_HUMAN Mitogen-activated protein kinase 14 (sprot)


Q8IEK1_PLAF7 M1-family alanyl aminopeptidase (trembl)


Q75760_9HIV1 Envelope glycoprotein gp160 (trembl)


PA_I34A1 Polymerase acidic protein (sprot)


EYA2_HUMAN Eyes absent homolog 2 (sprot)


Q6QLK5_9HIV1 Envelope glycoprotein gp160 (trembl)


Q9HXM5_PSEAE Inosine-5'-monophosphate dehydrogenase (trembl)


Benziodarone

minor descriptor (75-89); on-line & INDEX MEDICUS search BENZOFURANS (68-89) & IODOBENZOATES (74)


BIRC5_HUMAN Baculoviral IAP repeat-containing protein 5 (sprot)


SCN8A_HUMAN Sodium channel protein type 8 subunit alpha (sprot)


KCNJ6_HUMAN G protein-activated inward rectifier potassium channel 2 (sprot)


KCNJ3_HUMAN G protein-activated inward rectifier potassium channel 1 (sprot)


KCNJ5_HUMAN G protein-activated inward rectifier potassium channel 4 (sprot)


KLF10_HUMAN Krueppel-like factor 10 (sprot)


HMDH_HUMAN 3-hydroxy-3-methylglutaryl-coenzyme A reductase (sprot)


HMDH_RAT 3-hydroxy-3-methylglutaryl-coenzyme A reductase (sprot)


HMDH_PIG 3-hydroxy-3-methylglutaryl-coenzyme A reductase (sprot)


PYRD_HUMAN Dihydroorotate dehydrogenase (quinone), mitochondrial (sprot)


QCR1_EUGGR Ubiquinol-cytochrome-c reductase complex core protein I, mitochondrial (sprot)


PYRD_RAT Dihydroorotate dehydrogenase (quinone), mitochondrial (sprot)


Q54A96_PLAFA Dihydroorotate dehydrogenase (quinone), mitochondrial (trembl)


KCNN3_RAT Small conductance calcium-activated potassium channel protein 3 (sprot)


ACHA3_HUMAN Neuronal acetylcholine receptor subunit alpha-3 (sprot)


ACM2_MOUSE Muscarinic acetylcholine receptor M2 (sprot)


Q8WMX0_BOVIN Muscarinic receptor M1 (Fragment) (trembl)


Q8VH26_CAVPO Muscarinic acetylcholine receptor (trembl)


A9XFY4_MUSDO Nicotinic acetylcholine receptor alpha 5 subunit (trembl)


Azasetron

a selective 5-HT3 receptor antagonist; structure given in first source


MRP4_HUMAN ATP-binding cassette sub-family C member 4 (sprot)


RAC1_HUMAN Ras-related C3 botulinum toxin substrate 1 (sprot)


TPMT_HUMAN Thiopurine S-methyltransferase (sprot)


S5A2_HUMAN 3-oxo-5-alpha-steroid 4-dehydrogenase 2 (sprot)


HRH3_HUMAN Histamine H3 receptor (sprot)


KCNH2_CAVPO Potassium voltage-gated channel subfamily H member 2 (Fragment) (sprot)


KCNQ1_CAVPO Potassium voltage-gated channel subfamily KQT member 1 (sprot)


KCNQ1_MOUSE Potassium voltage-gated channel subfamily KQT member 1 (sprot)


PBPA_PSEAE Penicillin-binding protein 1A (sprot)


Q51504_PSEAI Peptidoglycan D,D-transpeptidase FtsI (trembl)


Q51505_PSEAI Peptidoglycan D,D-transpeptidase FtsI (trembl)


Q9X6V3_PSEAI Peptidoglycan D,D-transpeptidase MrdA (trembl)


Q9X6V7_PSEAI Serine-type D-Ala-D-Ala carboxypeptidase (trembl)


Q9X6W0_PSEAI Penicillin-binding protein 1B (trembl)


Q3S5C3_SALNE Efflux transporter (trembl)


B2ZTR6_ACIBA Beta-lactamase (Fragment) (trembl)


CP2CJ_HUMAN Cytochrome P450 2C19 (sprot)


PSMD1_HUMAN 26S proteasome non-ATPase regulatory subunit 1 (sprot)


PSB8_HUMAN Proteasome subunit beta type-8 (sprot)


PPGB_HUMAN Lysosomal protective protein (sprot)


PSB1_HUMAN Proteasome subunit beta type-1 (sprot)


PSB2_HUMAN Proteasome subunit beta type-2 (sprot)


PSB5_HUMAN Proteasome subunit beta type-5 (sprot)


PSD1_HUMAN PH and SEC7 domain-containing protein 1 (sprot)


NFKB1_HUMAN Nuclear factor NF-kappa-B p105 subunit (sprot)


NFKB2_HUMAN Nuclear factor NF-kappa-B p100 subunit (sprot)


TF65_HUMAN Transcription factor p65 (sprot)


Q8IJT1_PLAF7 Proteasome subunit beta (trembl)


PSB8_MOUSE Proteasome subunit beta type-8 (sprot)


PSB9_HUMAN Proteasome subunit beta type-9 (sprot)


PSB10_HUMAN Proteasome subunit beta type-10 (sprot)


CLPP_STAA8 ATP-dependent Clp protease proteolytic subunit (sprot)


NR1I2_HUMAN Nuclear receptor subfamily 1 group I member 2 (sprot)


EDNRB_HUMAN Endothelin receptor type B (sprot)


EDNRB_RAT Endothelin receptor type B (sprot)


G3HDX1_CRIGR Alpha-1B adrenergic receptor (trembl)


KITH_HUMAN Thymidine kinase, cytosolic (sprot)


SCNBA_HUMAN Sodium channel protein type 11 subunit alpha (sprot)


SCN7A_HUMAN Sodium channel protein type 7 subunit alpha (sprot)


VMAT2_HUMAN Synaptic vesicular amine transporter (sprot)


S6A19_HUMAN Sodium-dependent neutral amino acid transporter B(0)AT1 (sprot)


LIPS_RAT Hormone-sensitive lipase (sprot)


CAC1A_HUMAN Voltage-dependent P/Q-type calcium channel subunit alpha-1A (sprot)


KCNQ4_HUMAN Potassium voltage-gated channel subfamily KQT member 4 (sprot)


CAC1C_RABIT Voltage-dependent L-type calcium channel subunit alpha-1C (sprot)


KCNT1_RAT Potassium channel subfamily T member 1 (sprot)


Q2Q167_9HEPC Core protein (Fragment) (trembl)


S22A8_HUMAN Organic anion transporter 3 (sprot)


ADRB1_RAT Beta-1 adrenergic receptor (sprot)


Q8VH27_CAVPO Muscarinic acetylcholine receptor (Fragment) (trembl)


Bethanidine

A guanidinium antihypertensive agent that acts by blocking adrenergic transmission. The precise mode of action is not clear.


Bevantolol

a beta-1 adrenoceptor antagonist that has been shown to be as effective as other beta blockers for the treatment of angina pectoris and hypertension


RXRA_HUMAN Retinoic acid receptor RXR-alpha (sprot)


RXRB_HUMAN Retinoic acid receptor RXR-beta (sprot)


RXRG_HUMAN Retinoic acid receptor RXR-gamma (sprot)


RXRB_MOUSE Retinoic acid receptor RXR-beta (sprot)


RXRG_MOUSE Retinoic acid receptor RXR-gamma (sprot)


RXRA_MOUSE Retinoic acid receptor RXR-alpha (sprot)


RXRA_RAT Retinoic acid receptor RXR-alpha (sprot)


CP26A_HUMAN Cytochrome P450 26A1 (sprot)


CP26B_HUMAN Cytochrome P450 26B1 (sprot)


NR1H2_HUMAN Oxysterols receptor LXR-beta (sprot)


NR1H3_HUMAN Oxysterols receptor LXR-alpha (sprot)


PPARA_HUMAN Peroxisome proliferator-activated receptor alpha (sprot)


PPARD_HUMAN Peroxisome proliferator-activated receptor delta (sprot)


FABPI_HUMAN Fatty acid-binding protein, intestinal (sprot)


FABPL_RAT Fatty acid-binding protein, liver (sprot)


Q5D1E9_STAAU Penicillin-binding protein 4 (trembl)


A1KS91_NEIMF Penicillin-binding protein 1A (trembl)


PRGR_RABIT Progesterone receptor (sprot)


AOFB_HUMAN Amine oxidase [flavin-containing] B (sprot)


LMBL1_HUMAN Lethal(3)malignant brain tumor-like protein 1 (sprot)


CP17A_HUMAN Steroid 17-alpha-hydroxylase/17,20 lyase (sprot)


CP51A_HUMAN Lanosterol 14-alpha demethylase (sprot)


I23O1_HUMAN Indoleamine 2,3-dioxygenase 1 (sprot)


AK1C3_HUMAN Aldo-keto reductase family 1 member C3 (sprot)


PF2R_HUMAN Prostaglandin F2-alpha receptor (sprot)


IDE_HUMAN Insulin-degrading enzyme (sprot)


NQO1_HUMAN NAD(P)H dehydrogenase [quinone] 1 (sprot)


ADRB1_MOUSE Beta-1 adrenergic receptor (sprot)


DRTS_TOXGO Bifunctional dihydrofolate reductase-thymidylate synthase (sprot)


DYR_PNECA Dihydrofolate reductase (sprot)


DYR_CHICK Dihydrofolate reductase (sprot)


Q8Z9J9_SALTI Dihydrofolate reductase (trembl)


PGH2_BOVIN Prostaglandin G/H synthase 2 (sprot)


VGLU3_RAT Vesicular glutamate transporter 3 (sprot)


ADA2A_BOVIN Alpha-2A adrenergic receptor (sprot)


A0A024AXB9_ZIKV Nonstructural protein 3 (Fragment) (trembl)


Bromperidol

bromine-substituted for chlorine in haloperidol; RN given refers to unlabeled parent cpd; structure


COMT_RAT Catechol O-methyltransferase (sprot)


S12A1_HUMAN Solute carrier family 12 member 1 (sprot)


S12A2_HUMAN Solute carrier family 12 member 2 (sprot)


ADRB3_MOUSE Beta-3 adrenergic receptor (sprot)


ADRB3_RAT Beta-3 adrenergic receptor (sprot)


KCNK3_HUMAN Potassium channel subfamily K member 3 (sprot)


KCND3_MOUSE Potassium voltage-gated channel subfamily D member 3 (sprot)


KCNK3_RAT Potassium channel subfamily K member 3 (sprot)


KCNK9_RAT Potassium channel subfamily K member 9 (sprot)


Buserelin

A potent synthetic analog of GONADOTROPIN-RELEASING HORMONE with D-serine substitution at residue 6, glycine10 deletion, and other modifications.


LSHR_HUMAN Lutropin-choriogonadotropic hormone receptor (sprot)


GNRHR_MOUSE Gonadotropin-releasing hormone receptor (sprot)


5HT2A_BOVIN 5-hydroxytryptamine receptor 2A (sprot)


S47A2_HUMAN Multidrug and toxin extrusion protein 2 (sprot)


Q4JEY0_TRIRU Squalene monooxygenase (trembl)


Q5NGQ3_FRATT Enoyl-[acyl-carrier-protein] reductase [NADH] (trembl)