D-xylulose reductase activity

Catalysis of the reaction: NAD+ + xylitol = D-xylulose + H+ + NADH.


azetidine-2-carboxylic acid acetyltransferase activity

biolink:MolecularActivity biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:NamedThing biolink:Occurrent biolink:OntologyClass biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

Catalysis of the reaction: L-azetidine-2-carboxylic acid + acetyl-CoA = CoA-SH + N-acetyl azetidine-2-carboxylic acid.


phosphatidate phosphatase activity

Catalysis of the reaction: a 1,2-diacylglycerol 3-phosphate + H2O = a 1,2-diacyl-sn-glycerol + phosphate.


acetyl-CoA C-acetyltransferase activity

Catalysis of the reaction: 2 acetyl-CoA = CoA + acetoacetyl-CoA.


sulfinoalanine decarboxylase activity

Catalysis of the reaction: 3-sulfino-L-alanine = hypotaurine + CO2.


glutamate dehydrogenase (NAD+) activity

Catalysis of the reaction: L-glutamate + H2O + NAD+ = 2-oxoglutarate + NH3 + NADH + H+.


tRNA dimethylallyltransferase activity

Catalysis of the reaction: dimethylallyl diphosphate + tRNA = diphosphate + tRNA containing 6-dimethylallyladenosine.


non-membrane spanning protein tyrosine phosphatase activity

Catalysis of the reaction: non-membrane spanning protein tyrosine phosphate + H2O = non-membrane spanning protein tyrosine + phosphate.


fructose 1,6-bisphosphate 1-phosphatase activity

Catalysis of the reaction: D-fructose 1,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate.


L-malate dehydrogenase activity

Catalysis of the reaction: (S)-malate + NAD+ = oxaloacetate + NADH + H+.


RNA nuclease activity

Catalysis of the hydrolysis of phosphodiester bonds in chains of RNA.


tubulin-glutamic acid ligase activity

Catalysis of the posttranslational transfer of one or more glutamate residues to the gamma-carboxyl group(s) of one or more specific glutamate residues on a tubulin molecule.


Catalysis of the reaction: acetoacetyl-CoA + acetyl-CoA + H2O = (S)-3-hydroxy-3-methylglutaryl-CoA + CoA + H+.


Catalysis of the reaction: isopentenyl diphosphate = dimethylallyl diphosphate.


Catalysis of the reaction: (R)-5-diphosphomevalonate + ATP = ADP + CO2 + H+ + isopentenyl diphosphate + phosphate.


phosphomevalonate kinase activity

Catalysis of the reaction: (R)-5-phosphomevalonate + ATP = (R)-5-diphosphomevalonate + ADP + H+.


hydroxymethylglutaryl-CoA reductase (NADPH) activity

Catalysis of the reaction: (R)-mevalonate + CoA + 2 NADP+ = (S)-3-hydroxy-3-methylglutaryl-CoA + 2 H+ + 2 NADPH.


mevalonate kinase activity

Catalysis of the reaction: (R)-mevalonate + ATP = (R)-5-phosphomevalonate + ADP + 2 H+.


iron ion binding

Binding to an iron (Fe) ion.


triokinase activity

Catalysis of the reaction: D-glyceraldehyde + ATP = D-glyceraldehyde 3-phosphate + ADP + 2 H+.


fructose-1-phosphate aldolase activity

Catalysis of the reaction: D-fructose-1-phosphate = dihydroxyacetone phosphate + D-glyceraldehyde.


ketohexokinase activity

Catalysis of the reaction: ATP + D-fructose = ADP + D-fructose 1-phosphate.


glycerate kinase activity

Catalysis of the reaction: D-glycerate + ATP = 3-phospho-D-glycerate + ADP + 2 H+.


aldehyde dehydrogenase (NAD+) activity

Catalysis of the reaction: an aldehyde + NAD+ + H2O = an acid + NADH + H+.


Catalysis of the reaction: an alditol + NADP+ = an aldose + NADPH + H+.


D-sorbitol dehydrogenase (acceptor) activity

Catalysis of the reaction: D-sorbitol + acceptor = L-sorbose + reduced acceptor.


L-iditol 2-dehydrogenase activity

Catalysis of the reaction: L-iditol + NAD+ = L-sorbose + NADH + H+.


Catalysis of the reaction: alpha-D-galactose 1-phosphate + UDP-D-glucose = alpha-D-glucose 1-phosphate + UDP-D-galactose.


galactokinase activity

Catalysis of the reaction: D-galactose + ATP = alpha-D-galactose 1-phosphate + ADP + 2 H+.


UDP-glucose 4-epimerase activity

Catalysis of the reaction: UDP-glucose = UDP-galactose.


6-phosphogluconolactonase activity

Catalysis of the reaction: 6-O-phosphono-D-glucono-1,5-lactone + H2O = 6-phospho-D-gluconate + H+.


phosphogluconate dehydrogenase (decarboxylating) activity

Catalysis of the reaction: 6-phospho-D-gluconate + NADP+ = D-ribulose 5-phosphate + CO2 + NADPH + H+.


ribose-5-phosphate isomerase activity

Catalysis of the reaction: D-ribose 5-phosphate = D-ribulose 5-phosphate.


transketolase activity

Catalysis of the reversible transfer of a 2-carbon ketol group (CH2OH-CO-) from a ketose phosphate donor to an aldose phosphate acceptor.


Catalysis of the reaction: D-ribulose 5-phosphate = D-xylulose 5-phosphate.


transaldolase activity

Catalysis of the reaction: sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = D-erythrose 4-phosphate + D-fructose 6-phosphate.


bisphosphoglycerate mutase activity

Catalysis of the reaction: 3-phospho-D-glyceroyl phosphate = 2,3-bisphospho-D-glycerate.


ribokinase activity

Catalysis of the reaction: ATP + D-ribose = ADP + D-ribose 5-phosphate.


ribose phosphate diphosphokinase activity

Catalysis of the reaction: D-ribose 5-phosphate + ATP = 5-phospho-alpha-D-ribose 1-diphosphate + AMP + 2 H+.


4-alpha-glucanotransferase activity

Catalysis of the transfer of a segment of a (1->4)-alpha-D-glucan to a new 4-position in an acceptor, which may be glucose or (1->4)-alpha-D-glucan.


phosphorylase kinase activity

Catalysis of the reaction: 4 ATP + 2 phosphorylase b = 4 ADP + phosphorylase a.


amylo-alpha-1,6-glucosidase activity

Catalysis of the hydrolysis of (1->6)-alpha-D-glucosidic branch linkages in glycogen phosphorylase limit dextrin. Limit dextrin is the highly branched core that remains after exhaustive treatment of glycogen with glycogen phosphorylase. It is formed because these enzymes cannot hydrolyze the (1->6) glycosidic linkages present.


xylulokinase activity

Catalysis of the reaction: D-xylulose + ATP = D-xylulose 5-phosphate + ADP + 2 H+.


Catalysis of the reaction: 3-dehydro-L-gulonate + H+ = L-xylulose + CO2.


L-gulonate 3-dehydrogenase activity

Catalysis of the reaction: L-gulonate + NAD+ = 3-dehydro-L-gulonate + H+ + NADH.


L-glucuronate reductase activity

Catalysis of the reaction: L-gulonate + NADP+ = D-glucuronate + H+ + NADPH.


L-xylulose reductase (NADP+) activity

Catalysis of the reaction: NADP+ + xylitol = L-xylulose + H+ + NADPH.


small molecule sensor activity

Binding to a small molecule and eliciting a change in the protein's activity in response to the intracellular level of that small molecule.


arginine binding

Binding to 2-amino-5-(carbamimidamido)pentanoic acid.


alcohol dehydrogenase (NADP+) activity

Catalysis of the reaction: an alcohol + NADP+ = an aldehyde + NADPH + H+.


6-methylsalicylic acid synthase activity

Catalysis of the reaction: acetyl-CoA + 3 H+ + 3 malonyl-CoA + NADPH = 6-methylsalicylate + 3 CO2 + 4 CoA + H2O + NADP+.


Catalysis of the reaction: 6-methylsalicylate + H+ = 3-cresol + CO2.


aldo-keto reductase (NADP) activity

Catalysis of the reaction: an alcohol + NADP+ = an aldehyde or a ketone + NADPH + H+.


sulfate adenylyltransferase (ATP) activity

Catalysis of the reaction: ATP + sulfate = diphosphate + adenylylsulfate.


adenylylsulfate kinase activity

Catalysis of the reaction: ATP + adenylylsulfate = ADP + 3'-phosphoadenosine 5'-phosphosulfate.


alpha-mannosidase activity

Catalysis of the hydrolysis of terminal, non-reducing alpha-D-mannose residues in alpha-D-mannosides.


ATP citrate synthase activity

Catalysis of the reaction: acetyl-CoA + ADP + H+ + oxaloacetate + phosphate = ATP + citrate + CoA.


O-methyltransferase activity

Catalysis of the transfer of a methyl group to the oxygen atom of an acceptor molecule.


enoyl-CoA hydratase activity

Catalysis of the reaction: a 3-hydroxy-fatty acyl-CoA = a enoyl-CoA + H2O. This reaction usually occurs in the reverse direction, leading to the reduction of the double bound of enoyl-CoA in position 2 or 3. Specific reactions catalyzed include: a 4-saturated-(3S)-3-hydroxyacyl-CoA = a (3E)-enoyl-CoA + H2O and a (3S)-3-hydroxyacyl-CoA = a (2E)-enoyl-CoA + H2O.


polyketide synthase activity

Catalysis of a multistep reaction that produce polyketides through decarboxylative condensation of carboxylic acids. The key chain-building reaction, a C-N bond-forming reaction, involves the generation of the characteristic peptide bond by nucleophilic attack of the amino group of an amino-acyl donor unit covalently bound to a downstream peptidyl carrier protein module (amino acyl-S-PCP) on the acyl group of an upstream electrophilic acyl- or peptidyl acyl-S-PCP chain, catalyzed by a condensation (C) domain. Supplementing these core chain-elongation domains are variable numbers of auxiliary domains that are responsible for modification of the growing polypeptide chain by a small set of iterated reactions including epimerization, N-methylation, and heterocyclization.


acyl-CoA hydrolase activity

Catalysis of the reaction: acyl-CoA + H2O = CoA + a carboxylate.


cysteine-type endopeptidase inhibitor activity involved in apoptotic process

Binds to and stops, prevents or reduces the activity of a cysteine-type endopeptidase involved in the apoptotic process.


isopenicillin-N synthase activity

Catalysis of the reaction: N-[(5S)-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine + O2 = 2 H2O + isopenicillin N.


Catalysis of the reaction: L-2-aminoadipate + L-cysteine + L-valine + 3 ATP + H2O = N-[(5S)-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine + 3 AMP + 3 diphosphate + 6 H+.


carboxypeptidase activity

Catalysis of the hydrolysis of a single C-terminal amino acid residue from a polypeptide chain.


cyclase activity

Catalysis of a ring closure reaction.


versicolorin B synthase activity

Catalysis of the reaction: versiconal = versicolorin B + H2O.


Catalysis of the reaction: sterigmatocystin + S-adenosyl-L-methionine = 7-O-methylsterigmatocystin + S-adenosyl-homocysteine.


Catalyzes the reaction: (1'S,5'S)-hydroxyaverantin + NAD+ <=> 5'-oxoaverantin + NADH.


flavin reductase (NADH) activity

Catalysis of the reaction: a reduced flavin + NAD+ = an oxidized flavin + 2 H+ + NADH.


versicolorin reductase activity

Catalysis of the reduction of versicolorin A to sterigmatocystin.


acyltransferase activity

Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor).


Catalysis of the reaction: adenosine 3',5'-bisphosphate + H2O = adenosine 5'-phosphate + phosphate.


eukaryotic translation initiation factor 2alpha kinase activity

Catalysis of the reaction: ATP + [eukaryotic translation initiation factor 2 alpha subunit] = ADP + [eukaryotic translation initiation factor 2 alpha subunit] phosphate.


metallocarboxypeptidase activity

Catalysis of the hydrolysis of a single C-terminal amino acid residue from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.


peroxisome matrix targeting signal-2 binding

Binding to a type 2 peroxisome targeting signal, a nonapeptide with a broad consensus sequence of (R/K)-(L/V/I)-(XXXXX)-(H/Q)-(L/A/F).


lactoylglutathione lyase activity

Catalysis of the reaction: (R)-S-lactoylglutathione = glutathione + methylglyoxal.


guanylate cyclase activity

Catalysis of the reaction: GTP = 3',5'-cyclic GMP + diphosphate.


Catalysis of the reaction: L-histidyl-[protein] + S-adenosyl-L-methionine = N(tele)-methyl-L-histidyl-[protein] + S-adenosyl-L-homocysteine.


aconitate hydratase activity

Catalysis of the reaction: citrate = isocitrate. The reaction occurs in two steps: (1) citrate = cis-aconitate + H2O, (2) cis-aconitate + H2O = isocitrate. This reaction is the interconversion of citrate and isocitrate via the labile, enzyme-bound intermediate cis-aconitate. Water is removed from one part of the citrate molecule and added back to a different atom to form isocitrate.


malate dehydrogenase (decarboxylating) (NADP+) activity

Catalysis of the reaction: (S)-malate + NADP+ = pyruvate + CO2 + NADPH + H+.


isocitrate dehydrogenase (NADP+) activity

Catalysis of the reaction: isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.


L-lactate dehydrogenase activity

Catalysis of the reaction: (S)-lactate + NAD+ = pyruvate + NADH + H+.


N-acetylglucosamine kinase activity

Catalysis of the reaction: N-acetyl-D-glucosamine + ATP = N-acetyl-D-glucosamine 6-phosphate + ADP + 2 H+.


pyridoxamine phosphate oxidase activity

Catalysis of the reaction: pyridoxamine 5'-phosphate + H2O + O2 = pyridoxal 5'-phosphate + NH4+ + hydrogen peroxide. This activity can also oxidize pyridoxine 5'-phosphate to  pyridoxal 5'-phosphate + hydrogen peroxide.


UDP-glucose 6-dehydrogenase activity

Catalysis of the reaction: H2O + 2 NAD+ + UDP-alpha-D-glucose = 3 H+ + 2 NADH + UDP-alpha-D-glucuronate.


K48-linked deubiquitinase activity

Hydrolysis of a ubiquitin unit from a ubiquitinated protein linked via the Lys48 residue of ubiquitin.


6-phosphofructo-2-kinase activity

Catalysis of the reaction: beta-D-fructose 6-phosphate + ATP = beta-D-fructose 2,6-bisphosphate + ADP + 2 H+.


retinal dehydrogenase activity

Catalysis of the reaction: retinal + NAD+ + H2O = retinoate + NADH. Acts on both 11-trans and 13-cis forms of retinal.


protein-L-isoaspartate (D-aspartate) O-methyltransferase activity

Catalysis of the reaction: S-adenosyl-L-methionine + protein L-beta-aspartate = S-adenosyl-L-homocysteine + protein L-beta-aspartate methyl ester.


Catalysis of the reaction: D-fructose 2,6-bisphosphate + H2O = D-fructose-6-phosphate + phosphate.


aspartoacylase activity

Catalysis of the reaction: N-acyl-L-aspartate + H2O = a fatty acid anion + L-aspartate.


metalloaminopeptidase activity

Catalysis of the hydrolysis of a single N-terminal amino acid residue from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.


acetyl-CoA carboxylase activity

Catalysis of the reaction: ATP + acetyl-CoA + HCO3- = ADP + phosphate + malonyl-CoA.


inositol hexakisphosphate kinase activity

Catalysis of the reaction: ATP + 1D-myo-inositol 1,2,3,4,5,6-hexakisphosphate = ADP + diphospho-1D-myo-inositol-pentakisphosphate. The isomeric configuration of diphospho-1D-myo-inositol-pentakisphosphate (PP-IP5) is unknown.


glycerol kinase activity

Catalysis of the reaction: ATP + glycerol = sn-glycerol 3-phosphate + ADP + 2 H+.


oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor

Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces oxygen.


guanyl nucleotide binding

Binding to a guanyl nucleotide, consisting of guanosine esterified with (ortho)phosphate.


thiamine diphosphokinase activity

Catalysis of the reaction: ATP + thiamine = AMP + thiamine diphosphate.


riboflavin kinase activity

Catalysis of the reaction: ATP + riboflavin = ADP + FMN + 2 H+.


FMN adenylyltransferase activity

Catalysis of the reaction: ATP + FMN = diphosphate + FAD.


thiamine triphosphate phosphatase activity

Catalysis of the reaction: H2O + thiamine triphosphate = thiamine diphosphate + H+ + phosphate.


thiamine-diphosphate kinase activity

Catalysis of the reaction: ATP + thiamin diphosphate = ADP + thiamin triphosphate.


Catalysis of the reaction: N-[(R)-4-phosphonatopantothenoyl]-L-cysteinate + H+ = CO2 + pantetheine 4'-phosphate.


pantothenate kinase activity

Catalysis of the reaction: ATP + pantothenate = ADP + D-4'-phosphopantothenate.


Catalysis of the reaction: CTP + (R)-4'-phosphopantothenate + L-cysteine = CMP + diphosphate + (R)-4'-phosphopantothenoyl-L-cysteine. Cysteine can be replaced by some of its derivatives.


UFM1 ligase activity

Catalysis of the transfer of UFM1 to a substrate protein via the reaction X-UFM1 + S = X + S-UFM1, where X is either an E2 or E3 enzyme, the X-UFM1 linkage is a thioester bond, and the S-UFM1 linkage is an isopeptide bond between the C-terminal amino acid of UFM1 and the epsilon-amino group of lysine residues in the substrate.


phosphotransferase activity, alcohol group as acceptor

Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor).


pyridoxal kinase activity

Catalysis of the reaction: ATP + pyridoxal = ADP + pyridoxal 5'-phosphate.


pyridoxal phosphatase activity

Catalysis of the reaction: pyridoxal 5'-phosphate + H2O = pyridoxal + phosphate.


pyridoxal oxidase activity

Catalysis of the reaction: pyridoxal + H2O + O2 = 4-pyridoxate + hydrogen peroxide.


biotin-protein ligase activity

Catalysis of the reaction: ATP + biotin + protein = AMP + diphosphate + biotin-protein.


sulfurtransferase activity

Catalysis of the transfer of sulfur atoms from one compound (donor) to another (acceptor).


Catalysis of the reaction adenylyl-molybdopterin + molybdate = molybdenum cofactor + AMP.


molybdopterin synthase activity

Catalysis of the conversion of precursor Z to molybdopterin, the final step in molybdopterin biosynthesis.


cysteine desulfurase activity

Catalysis of the reaction: L-cysteine + [enzyme]-cysteine = L-alanine + [enzyme]-S-sulfanylcysteine.


Mo-molybdopterin cofactor sulfurase activity

Catalysis of the sulfurylation of the desulfo form of molybdenum cofactor (MoCo), a cofactor required for the activity of some enzymes, such as aldehyde oxidase.


glycerol-3-phosphate dehydrogenase [NAD(P)+] activity

Catalysis of the reaction: sn-glycerol 3-phosphate + NAD(P)+ = glycerone phosphate + NAD(P)H + H+.


catechol O-methyltransferase activity

Catalysis of the reaction: S-adenosyl-L-methionine + a catechol = S-adenosyl-L-homocysteine + a guaiacol.


cysteine-type endopeptidase activator activity involved in apoptotic process

Binds to and increases the rate of proteolysis catalyzed by a cysteine-type endopeptidase involved in the apoptotic process.


porphobilinogen synthase activity

Catalysis of the reaction: 2 5-aminolevulinate = 2 H2O + H+ + porphobilinogen.


uroporphyrinogen-III synthase activity

Catalysis of the reaction: hydroxymethylbilane = H2O + uroporphyrinogen III.


uroporphyrinogen decarboxylase activity

Catalysis of the reaction: uroporphyrinogen-III = coproporphyrinogen + 4 CO2.


hydroxymethylbilane synthase activity

Catalysis of the reaction: H2O + 4 porphobilinogen = hydroxymethylbilane + 4 NH4.


Catalysis of the reaction: NAD+ + 4-trimethylammoniobutanal = NADH + 4-trimethylammoniobutanoate.


aldehyde-lyase activity

Catalysis of the cleavage of a C-C bond in a molecule containing a hydroxyl group and a carbonyl group to form two smaller molecules, each being an aldehyde or a ketone.


Catalysis of the reaction: 2-oxoglutarate + 4-(trimethylammonio)butanoate + O2 = carnitine + CO2 + succinate.


phospholipase activity

Catalysis of the hydrolysis of a glycerophospholipid.


phospholipase A2 activity

Catalysis of the reaction: a 1,2-diacyl-sn-glycero-3-phospholipid + H2O = 1-acyl-sn-glycero-3-phospholipid + a fatty acid. This reaction removes the fatty acid attached to the sn2-position. Substrates include phosphatidylcholine, phosphatidylethanolamine, choline plasmalogen and phosphatides.


carbonate dehydratase activity

Catalysis of the reaction: H2CO3 = CO2 + H2O.


NADP-retinol dehydrogenase activity

Catalysis of the reaction: all-trans-retinol + NADP+ = all-trans-retinal + NADPH + H+.


Catalysis of the reaction: tetradecanoyl-CoA + glycyl-peptide = CoA + N-tetradecanoylglycyl-peptide.


cytoskeletal motor activity

Generation of force resulting in movement, for example along a microfilament or microtubule, or in torque resulting in membrane scission or rotation of a flagellum. The energy required is obtained either from the hydrolysis of a nucleoside triphosphate or by an electrochemical proton gradient (proton-motive force).


sulfotransferase activity

Catalysis of the transfer of a sulfate group from 3'-phosphoadenosine 5'-phosphosulfate to the hydroxyl group of an acceptor, producing the sulfated derivative and 3'-phosphoadenosine 5'-phosphate.


aryl sulfotransferase activity

Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + a phenol = adenosine 3',5'-bisphosphate + an aryl sulfate.


SNARE binding

Binding to a SNARE (soluble N-ethylmaleimide-sensitive factor attached protein receptor) protein.


Catalysis of the reaction: a branched-chain amino acid + 2-oxoglutarate = L-glutamate + a 2-oxocarboxylate derived from the branched-chain amino acid.


glutamate-cysteine ligase activity

Catalysis of the reaction: L-cysteine + L-glutamate + ATP = L-gamma-glutamyl-L-cysteine + ADP + 2 H+ + phosphate.


cysteine dioxygenase activity

Catalysis of the reaction: L-cysteine + O2 = 3-sulfino-L-alanine + H+.


N-acylglucosamine 2-epimerase activity

Catalysis of the reaction: N-acyl-D-glucosamine = N-acyl-D-mannosamine.


electron transfer activity

Any molecular entity that serves as an electron acceptor and electron donor in an electron transport chain. An electron transport chain is a process in which a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient.


methylenetetrahydrofolate reductase (NAD(P)H) activity

Catalysis of the reaction: 5-methyltetrahydrofolate + NAD(P)+ = 5,10-methylenetetrahydrofolate + NAD(P)H + H+.


peptide-methionine (S)-S-oxide reductase activity

Catalysis of the reactions: peptide-L-methionine + thioredoxin disulfide + H2O = peptide-L-methionine (S)-S-oxide + thioredoxin, and L-methionine + thioredoxin disulfide + H2O = L-methionine (S)-S-oxide + thioredoxin. Can act on oxidized methionine in peptide linkage with specificity for the S enantiomer. Thioredoxin disulfide is the oxidized form of thioredoxin.


carbonyl reductase (NADPH) activity

Catalysis of the reaction: R-CHOH-R' + NADP+ = R-CO-R' + NADPH + H+.


calcium-dependent cysteine-type endopeptidase activity

Catalysis of the hydrolysis of nonterminal peptide bonds in a polypeptide chain by a mechanism using a cysteine residue at the enzyme active center, and requiring the presence of calcium.


peroxidase activity

Catalysis of the reaction: a donor + a peroxide = an oxidized donor + 2 H2O.


15-hydroxyprostaglandin dehydrogenase (NAD+) activity

Catalysis of the reaction: (5Z,13E)-(15S)-11-alpha,15-dihydroxy-9-oxoprost-13-enoate + NAD+ = (5Z,13E)-11-alpha-hydroxy-9,15-dioxoprost-13-enoate + NADH + H+.


selenide, water dikinase activity

Catalysis of the reaction: ATP + H2O + hydrogen selenide = AMP + 3 H+ + phosphate + selenophosphorate.


calmodulin-activated dual specificity 3',5'-cyclic-GMP, 3',5'-cyclic-AMP phosphodiesterase activity

Catalysis of the reactions: 3',5'-cyclic AMP + H2O = AMP + H+ and 3',5'-cyclic GMP + H2O = GMP + H+; this activity is activated by binding to calcium-bound calmodulin.


arylamine N-acetyltransferase activity

Catalysis of the reaction: acetyl-CoA + an arylamine = CoA + an N-acetylarylamine.


Catalysis of the reaction: 1D-myo-inositol 1,4,5-trisphosphate + ATP = 1D-myo-inositol 1,3,4,5-tetrakisphosphate + ADP + 2 H+.


spermine synthase activity

Catalysis of the reaction: S-adenosylmethioninamine + spermidine = 5'-methylthioadenosine + spermine.


thioredoxin peroxidase activity

Catalysis of the reaction: [thioredoxin]-dithiol + hydrogen peroxide = [thioredoxin]-disulfide + H2O.


Catalysis of the reaction: S-adenosyl-L-methionine(1+) + nicotinamide = 1-methylnicotinamide + S-adenosyl-L-homocysteine.


inositol bisphosphate phosphatase activity

Catalysis of the reaction: myo-inositol bisphosphate + H2O = myo-inositol phosphate + phosphate.


NAD-retinol dehydrogenase activity

Catalysis of the reaction: retinol + NAD+ = retinal + NADH + H+.


Catalysis of the reaction: 3',5'-cyclic GMP + H2O = GMP + H+.


Catalysis of the reaction: arachidonate + O2 = (5Z,8Z,10E,12S,14Z)-12-hydroperoxyicosa-5,8,10,14-tetraenoate.


sphinganine kinase activity

Catalysis of the reaction: ATP + sphinganine = ADP + sphinganine 1-phosphate.


arginase activity

Catalysis of the reaction: L-arginine + H2O = L-ornithine + urea.


Catalysis of the reaction: S-adenosyl-L-methionine + H+ = S-adenosylmethioninamine + CO2.


tubulin deacetylase activity

Catalysis of the reaction: N-acetyl(alpha-tubulin) + H2O = alpha-tubulin + acetate.


steroid hydroxylase activity

Catalysis of the formation of a hydroxyl group on a steroid by incorporation of oxygen from O2.


Catalysis of the reaction: 7,8-dihydroneopterin 3'-triphosphate = 6-pyruvoyl-5,6,7,8-tetrahydropterin + H+ + triphosphate.


protein-arginine deiminase activity

Catalysis of the reaction: H2O + L-arginyl-[protein] = L-citrullyl-[protein] + NH4+, resulting in citrullination of the target protein. This reaction is calcium-dependent.


glutamine-fructose-6-phosphate transaminase (isomerizing) activity

Catalysis of the reaction: beta-D-fructose 6-phosphate + L-glutamine = D-glucosamine 6-phosphate + L-glutamate.


Catalysis of the reaction: 5-formimidoyltetrahydrofolate + 2 H+ = 5,10-methenyltetrahydrofolate + NH4.


Catalysis of the reaction: L-homocysteine + glycine betaine = N,N-dimethylglycine + L-methionine.


cystathionine gamma-lyase activity

Catalysis of the reaction: L-cystathionine + H2O = 2-oxobutanoate + L-cysteine + NH4+.


geranyltranstransferase activity

Catalysis of the reaction: geranyl diphosphate + isopentenyl diphosphate = 2-trans,6-trans-farnesyl diphosphate + diphosphate.


phospholipase A1 activity

Catalysis of the reaction: phosphatidylcholine + H2O = 2-acylglycerophosphocholine + a carboxylate.


maleylacetoacetate isomerase activity

Catalysis of the reaction: 4-maleylacetoacetate = 4-fumarylacetoacetate.


lysine N-acetyltransferase activity, acting on acetyl phosphate as donor

Catalysis of the reaction: acetyl phosphate + L-lysine = phosphate + N6-acetyl-L-lysine.


Catalysis of the reaction: ATP = pppA(2'p5'A)n oligomers. This reaction requires the binding of double-stranded RNA.


methionine-tRNA ligase activity

Catalysis of the reaction: ATP + L-methionine + tRNA(Met) = AMP + diphosphate + L-methionyl-tRNA(Met).


Catalysis of the reaction: D-glucosamine 6-phosphate + H2O = beta-D-fructose 6-phosphate + NH4.


very long-chain fatty acid-CoA ligase activity

Catalysis of the reaction: ATP + a very-long-chain fatty acid + CoA = AMP + diphosphate + an acyl-CoA; a very long-chain fatty acid is a fatty acid which has a chain length greater than C22.


Catalysis of the reaction: 3-hydroxyanthranilate + O2 = cis,cis-2-amino-3-(3-oxoprop-1-enyl)but-2-enedioate + H+.


alcohol dehydrogenase activity, zinc-dependent

Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+, requiring the presence of zinc.


Catalysis of the reaction: NADPH + H+ + quinone = NADP+ + semiquinone.


asparagine synthase (glutamine-hydrolyzing) activity

Catalysis of the reaction: ATP + L-aspartate + L-glutamine = AMP + diphosphate + L-asparagine + L-glutamate.


peptide-methionine (R)-S-oxide reductase activity

Catalysis of the reaction: peptide-L-methionine + H2O + thioredoxin disulfide = peptide-L-methionine (R)-S-oxide + thioredoxin. Can act on oxidized methionine in peptide linkage with specificity for the R enantiomer. Thioredoxin disulfide is the oxidized form of thioredoxin.


serine racemase activity

Catalysis of the synthesis of free D-serine from L-serine.


adenyl-nucleotide exchange factor activity

Binds to and stimulates the hydrolysis and exchange of adenyl nucleotides by other proteins.


phosphoglycerate dehydrogenase activity

Catalysis of the reaction: 3-phosphoglycerate + NAD+ = 3-phosphohydroxypyruvate + NADH + H+.


dipeptidase activity

Catalysis of the hydrolysis of a dipeptide.


carboxylic ester hydrolase activity

Catalysis of the hydrolysis of a carboxylic ester bond.


Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 3-phosphate + H2O = 1-phosphatidyl-1D-myo-inositol + phosphate.


dimethylargininase activity

Catalysis of the reaction: N(G),N(G)-dimethyl-L-arginine + H2O = dimethylamine + L-citrulline.


glucosamine 6-phosphate N-acetyltransferase activity

Catalysis of the reaction: D-glucosamine 6-phosphate + acetyl-CoA = N-acetyl-D-glucosamine 6-phosphate + CoA + H+.


prostaglandin-D synthase activity

Catalysis of the reaction: prostaglandin H(2) = prostaglandin D(2).


N-acylmannosamine kinase activity

Catalysis of the reaction: ATP + N-acyl-D-mannosamine = ADP + N-acyl-D-mannosamine 6-phosphate.


aldehyde dehydrogenase [NAD(P)+] activity

Catalysis of the reaction: an aldehyde + NAD(P)+ + H2O = an acid + NAD(P)H + H+.


acetate-CoA ligase activity

Catalysis of the reaction: ATP + acetate + CoA = AMP + diphosphate + acetyl-CoA.


Catalysis of the reaction: a glycerophosphodiester + H2O = an alcohol + sn-glycerol 3-phosphate.


Catalysis of the reaction: 4-N-(N-acetyl-D-glucosaminyl)-protein + H2O = N-acetyl-beta-D-glucosaminylamine + peptide L-aspartate. This reaction is the hydrolysis of an N4-(acetyl-beta-D-glucosaminyl)asparagine residue in which the N-acetyl-D-glucosamine residue may be further glycosylated, to yield a (substituted) N-acetyl-beta-D-glucosaminylamine and the peptide containing an aspartic residue.


UDP-sugar diphosphatase activity

Catalysis of the reaction: UDP-sugar + H2O = UMP + sugar 1-phosphate.


ADP-ribose diphosphatase activity

Catalysis of the reaction: ADP-ribose + H2O = AMP + D-ribose 5-phosphate.


asparaginase activity

Catalysis of the reaction: L-asparagine + H2O = L-aspartate + NH3.


Catalysis of the reaction: ATP + nicotinamide nucleotide = diphosphate + NAD+.


pseudouridine synthase activity

Catalysis of the reaction: RNA uridine = RNA pseudouridine. Conversion of uridine in an RNA molecule to pseudouridine by rotation of the C1'-N-1 glycosidic bond of uridine in RNA to a C1'-C5.


nicotinate-nucleotide diphosphorylase (carboxylating) activity

Catalysis of the reaction: CO2 + diphosphate + nicotinate D-ribonucleotide = 5-phospho-alpha-D-ribose 1-diphosphate + 2 H+ + quinolinate.


ferroxidase activity

Catalysis of the reaction: 4 Fe2+ + 4 H+ + O2 = 4 Fe3+ + 2 H2O.


glutamine-tRNA ligase activity

Catalysis of the reaction: ATP + L-glutamine + tRNA(Gln) = AMP + diphosphate + L-glutaminyl-tRNA(Gln).


diamine N-acetyltransferase activity

Catalysis of the reaction: acetyl-CoA + an alkane-alpha,omega-diamine = CoA + an N-acetyldiamine.


tubulin-tyrosine ligase activity

Catalysis of the reaction: ATP + detyrosinated alpha-tubulin + L-tyrosine = alpha-tubulin + ADP + phosphate.


aminoacylase activity

Catalysis of the reaction: an N-acyl-L-amino acid + H2O = a carboxylate + an L-amino acid.


aldehyde oxidase activity

Catalysis of the reaction: an aldehyde + H2O + O2 = a carboxylic acid + hydrogen peroxide.


phosphatidylinositol transfer activity

Removes phosphatidylinositol from a membrane or a monolayer lipid particle, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to an acceptor membrane or lipid particle.


ADP-specific glucokinase activity

Catalysis of the reaction: ADP + D-glucose = AMP + D-glucose 6-phosphate.


phenylalanine 4-monooxygenase activity

Catalysis of the reaction: L-phenylalanine + tetrahydrobiopterin + O2 = L-tyrosine + 4-alpha-hydroxytetrahydrobiopterin.


Catalysis of the reaction: S-adenosyl-L-methionine + calmodulin L-lysine = S-adenosyl-L-homocysteine + calmodulin N6-methyl-L-lysine.


N-acetylneuraminate lyase activity

Catalysis of the reaction: N-acetylneuraminate = N-acetyl-D-mannosamine + pyruvate.


Catalysis of the reaction: 5-oxo-L-proline + ATP + 2 H2O = L-glutamate + ADP + 2 H+ + phosphate.


dITP diphosphatase activity

Catalysis of the reaction: dITP + H2O = dIMP + H+ + diphosphate.


primary amine oxidase activity

Catalysis of the reaction: a primary amine + H2O + O2 = an aldehyde + NH3 + hydrogen peroxide.


Catalysis of the reaction: ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.


NAD+ synthase (glutamine-hydrolyzing) activity

Catalysis of the reaction: ATP + deamido-NAD+ + L-glutamine + H2O = AMP + diphosphate + NAD+ + L-glutamate.


Catalysis of the reaction: all-trans-beta-carotene + O2 = 2 all-trans-retinal.


guanylate kinase activity

Catalysis of the reaction: ATP + GMP = ADP + GDP.


acid phosphatase activity

Catalysis of the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an acid pH optimum.


Catalysis of the reaction: diphosphate + nicotinamide mononucleotide = 5-phospho-alpha-D-ribose 1-diphosphate + H+ + nicotinamide.


arsenite methyltransferase activity

Catalysis of the reaction: S-adenosyl-L-methionine + arsenite = S-adenosyl-L-homocysteine + methylarsonate.


Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol 3-phosphate + phosphate.


inositol monophosphate 1-phosphatase activity

Catalysis of the reaction: myo-inositol 1-phosphate + H2O = myo-inositol + phosphate.


estradiol 17-beta-dehydrogenase [NAD(P)] activity

Catalysis of the reaction: estradiol-17-beta + NAD(P)+ = estrone + NAD(P)H + H+. The activity can use NAD+ or NADP+ as the acceptor.


racemase and epimerase activity, acting on carbohydrates and derivatives

Catalysis of a reaction that alters the configuration of one or more chiral centers in a carbohydrate molecule.


isoleucine-tRNA ligase activity

Catalysis of the reaction: L-isoleucine + ATP + tRNA(Ile) = L-isoleucyl-tRNA(Ile) + AMP + diphosphate + 2 H+.


carnosine synthase activity

Catalysis of the reaction: ATP + L-histidine + beta-alanine = AMP + diphosphate + carnosine.


Catalysis of the reaction: H2O + phosphoenolpyruvate + N-acyl-D-mannosamine 6-phosphate = phosphate + N-acylneuraminate 9-phosphate.


Catalysis of the reaction: a 3-oxo-5-alpha-steroid + acceptor = a 3-oxo-delta(4)-steroid + reduced acceptor.


ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor

Catalysis of the reaction: 2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin. Thioredoxin disulfide is the oxidized form of thioredoxin.


1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O = 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + phosphate.


carboxy-lyase activity

Catalysis of the nonhydrolytic addition or removal of a carboxyl group to or from a compound.


oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from one donor, and two oxygen atoms is incorporated into a donor.


microtubule severing ATPase activity

Catalysis of the reaction: ATP + H2O = ADP + phosphate. Catalysis of the severing of a microtubule at a specific spot along its length, coupled to the hydrolysis of ATP.


ornithine decarboxylase activity

Catalysis of the reaction: L-ornithine + H+ = CO2 + putrescine.


arginine decarboxylase activity

Catalysis of the reaction: L-arginine + H+ = agmatine + CO2.


methionine adenosyltransferase activity

Catalysis of the reaction: ATP + L-methionine + H2O = phosphate + diphosphate + S-adenosyl-L-methionine.


glycine-tRNA ligase activity

Catalysis of the reaction: ATP + glycine + tRNA(Gly) = AMP + diphosphate + glycyl-tRNA(Gly).


exo-alpha-sialidase activity

Catalysis of the hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)-glycosidic linkages of terminal sialic residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates.


deoxyhypusine synthase activity

Catalysis of the reaction: [eIF5A-precursor]-lysine + spermidine = [eIF5A-precursor]-deoxyhypusine + propane-1,3-diamine. Four sub-reactions have been identified,in which the intermediates remain tightly associated with the enzyme: spermidine + NAD+ = dehydrospermidine + NADH; dehydrospermidine + [enzyme]-lysine = N-(4-aminobutylidene)-[enzyme]-lysine + propane-1,3-diamine; N-(4-aminobutylidene)-[enzyme]-lysine + [eIF5A-precursor]-lysine = N-(4-aminobutylidene)-[eIF5A-precursor]-lysine + [enzyme]-lysine; N-(4-aminobutylidene)-[eIF5A-precursor]-lysine + NADH + H+ = [eIF5A-precursor]-deoxyhypusine + NAD+.


Catalysis of the reaction: ATP + N-acetyl-L-aspartate + L-glutamate = ADP + phosphate + N-acetylaspartyl-glutamate.


Catalysis of the reaction: S-(hydroxymethyl)glutathione + NAD(P)+ = S-formylglutathione + NAD(P)H + H+.


adenosylhomocysteinase activity

Catalysis of the reaction: S-adenosyl-L-homocysteine + H2O = adenosine + L-homocysteine.


adenylate kinase activity

Catalysis of the reaction: ATP + AMP = 2 ADP.


biliverdin reductase (NAD(P)+) activity

Catalysis of the reaction: bilirubin + NAD(P)+ = biliverdin + NAD(P)H + H+.


cystathionine beta-synthase activity

Catalysis of the reaction: L-serine + L-homocysteine = cystathionine + H2O.


choline O-acetyltransferase activity

Catalysis of the reaction: acetyl-CoA + choline = acetylcholine + CoA.


Catalysis of the reaction: L-amino acid + H+ = R-H + CO2.


fumarylacetoacetase activity

Catalysis of the reaction: 4-fumarylacetoacetate + H2O = acetoacetate + fumarate + H+.


GTP cyclohydrolase I activity

Catalysis of the reaction: GTP + H2O = formate + 7,8-dihydroneopterin 3'-triphosphate.


Catalysis of the reaction: (S)-(2-hydroxyacyl)glutathione + H2O = glutathione + a 2-hydroxy carboxylate.


glutathione-disulfide reductase (NADP) activity

Catalysis of the reaction: 2 glutathione + NADP+ = glutathione disulfide + NADPH + H+.


glutathione synthase activity

Catalysis of the reaction: L-gamma-glutamyl-L-cysteine + ATP + glycine = ADP + glutathione + 2 H+ + phosphate.


histidine ammonia-lyase activity

Catalysis of the reaction: L-histidine = urocanate + NH3.


histidine decarboxylase activity

Catalysis of the reaction: L-histidine = histamine + CO2.


Catalysis of the reaction: 4-hydroxyphenylpyruvate + O2 = homogentisate + CO2.


tryptophan 2,3-dioxygenase activity

Catalysis of the reaction: L-tryptophan + O2 = N-formyl-L-kynurenine.


mannose-6-phosphate isomerase activity

Catalysis of the reaction: D-mannose 6-phosphate = D-fructose 6-phosphate.


Catalysis of the reaction: N-acetyl-alpha-D-glucosamine 1-phosphate = N-acetyl-D-glucosamine 6-phosphate.


transaminase activity

Catalysis of the transfer of an amino group to an acceptor, usually a 2-oxo acid.


tyrosine 3-monooxygenase activity

Catalysis of the reaction: L-tyrosine + tetrahydrobiopterin + O2 = 3,4-dihydroxy-L-phenylalanine + 4-alpha-hydroxytetrahydrobiopterin + H2O.


thiopurine S-methyltransferase activity

Catalysis of the reaction: S-adenosyl-L-methionine + a thiopurine = S-adenosyl-L-homocysteine + a thiopurine S-methylether.


isomerase activity

Catalysis of the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5.


Catalysis of the reaction: inositol-1,3,4,5-tetrakisphosphate + H2O = inositol-1,4,5-trisphosphate + phosphate.


acireductone dioxygenase [iron(II)-requiring] activity

Catalysis of the reaction: 1,2-dihydroxy-5-(methylthio)pent-1-en-3-one + O2 = 4-methylthio-2-oxobutanoate + formate + H+.


Catalysis of the reaction: S-methyl-5-thio-alpha-D-ribose 1-phosphate = S-methyl-5-thio-D-ribulose 1-phosphate.


methylthioribulose 1-phosphate dehydratase activity

Catalysis of the reaction: S-methyl-5-thio-D-ribulose 1-phosphate = 5-(methylthio)-2,3-dioxopentyl phosphate + H2O.


spermidine synthase activity

Catalysis of the reaction: S-adenosylmethioninamine + putrescine = 5'-methylthioadenosine + spermidine.


Catalysis of the reaction: 5'-methylthioadenosine + phosphate = adenine + 5-methylthio-D-ribose 1-phosphate.


acireductone synthase activity

Catalysis of the reactions: 5-(methylthio)-2,3-dioxopentyl phosphate + H2O = 1,2-dihydroxy-5-(methylthio)pent-1-en-3-one + phosphate; (1a) 5-(methylthio)-2,3-dioxopentyl phosphate = 2-hydroxy-5-(methylthio)-3-oxopent-1-enyl phosphate; (1b) 2-hydroxy-5-(methylthio)-3-oxopent-1-enyl phosphate + H2O = 1,2-dihydroxy-5-(methylthio)pent-1-en-3-one + phosphate.


sterol transporter activity

Enables the directed movement of sterols into, out of or within a cell, or between cells. Sterol are steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule.


spermine:oxygen oxidoreductase (spermidine-forming) activity

Catalysis of the reaction: H2O + O2 + spermine = 3-aminopropanal + H2O2 + spermidine.


N1-acetylspermidine:oxygen oxidoreductase (3-acetamidopropanal-forming) activity

Catalysis of the reaction: H2O + N(1)-acetylspermidine + O2 = 3-acetamidopropanal + H2O2 + putrescine.


cGMP-dependent protein kinase activity

cGMP dependent catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein.


sepiapterin reductase activity

Catalysis of the reaction: 7,8-dihydrobiopterin + NADP+ = sepiapterin + NADPH + H+.


phosphatidylinositol phosphate 4-phosphatase activity

Catalysis of the removal of the 4-phosphate group of a phosphatidylinositol phosphate.


Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol + ATP = 1-phosphatidyl-1D-myo-inositol 4-phosphate + ADP + 2 H+.


Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol 5-phosphate + phosphate + 2 H+.


phosphocholine phosphatase activity

Catalysis of the reaction: choline phosphate + H2O = choline + phosphate.


Catalysis of the reaction: O-phosphoethanolamine + H2O = ethanolamine + phosphate.


pyridine N-methyltransferase activity

Catalysis of the reaction: S-adenosyl-L-methionine(1+) + pyridine = N-methylpyridinium + S-adenosyl-L-homocysteine.


methylarsonate reductase activity

Catalysis of the reaction: 2 glutathione + H+ + methylarsonate = glutathione disulfide + H2O + methylarsonous acid.


thiol S-methyltransferase activity

Catalysis of the reaction: S-adenosyl-L-methionine + a thiol = S-adenosyl-L-homocysteine + a thioether.


Catalysis of the reaction: ATP + tetrahydrofolyl-(Glu)(n) + L-glutamate = ADP + phosphate + tetrahydrofolyl-(Glu)(n+1).


steroid sulfotransferase activity

Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + a phenolic steroid = adenosine 3',5'-bisphosphate + steroid O-sulfate.


estrone sulfotransferase activity

Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + estrone = adenosine 3',5'-bisphosphate + estrone 3-sulfate.


alcohol sulfotransferase activity

Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + an alcohol = adenosine 3',5'-bisphosphate + an alkyl sulfate.


peptidyltransferase activity

Catalysis of the reaction: peptidyl-tRNA(1) + aminoacyl-tRNA(2) = tRNA(1) + peptidylaminoacyl-tRNA(2). This reaction is catalyzed by a ribozyme.


Catalysis of the reaction: thiosulfate + 2 glutathione = sulfite + glutathione disulfide + sulfide.


L-cysteine desulfhydrase activity

Catalysis of the reaction: L-cysteine + H2O = ammonia + pyruvate + hydrogen sulfide + H+.


Catalysis of the reaction: S-methyl-L-methionine + L-homocysteine = 2 L-methionine + H+.


carbon-sulfur lyase activity

Catalysis of the elimination of hydrogen sulfide or substituted H2S.


hypotaurine dehydrogenase activity

Catalysis of the reaction: H+ + hypotaurine + NADPH + O2 = H2O + NADP+ + taurine.


cysteamine dioxygenase activity

Catalysis of the reaction: cysteamine + O2 = H+ + hypotaurine.


homocysteine desulfhydrase activity

Catalysis of the reaction: L-homocysteine + H2O = sulfide + NH3 + 2-oxobutanoate.


Catalysis of the reaction: a 1-phosphatidyl-1D-myo-inositol 3-phosphate + ATP = a 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate + ADP + 2 H+.


Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol 4-phosphate + phosphate.


Catalysis of the reaction: phosphatidylinositol-3,5-bisphosphate + H2O = phosphatidylinositol-3-phosphate + orthophosphate.


Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol + ATP = a 1-phosphatidyl-1D-myo-inositol 5-phosphate + ADP + 2 H+.


Catalysis of the reaction: a 1-phosphatidyl-1D-myo-inositol 3-phosphate + ATP = a 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate + ADP + 2 H+.


ceramide 1-phosphate transfer activity

Removes a ceramide 1-phosphate from a membrane or a monolayer lipid particle, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to an acceptor membrane or lipid particle.


glycolipid transfer activity

Removes a glycolipid from a membrane or a monolayer lipid particle, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to an acceptor membrane or lipid particle. A glycolipid is a compound usually containing 1-4 linked monosaccharide residues joined by a glycosyl linkage to a lipid.


gamma-glutamylcyclotransferase activity

Catalysis of the reaction: (5-L-glutamyl)-L-amino acid = 5-oxoproline + L-amino acid.


inositol pentakisphosphate 2-kinase activity

Catalysis of the reaction: 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ATP = 1D-myo-inositol hexakisphosphate + ADP + 2 H+.


Catalysis of the reaction: 1D-myo-inositol 1,3,4-trisphosphate + ATP = 1D-myo-inositol 1,3,4,5-tetrakisphosphate + ADP + 2 H+.


inositol diphosphate pentakisphosphate diphosphatase activity

Catalysis of the reaction: diphospho-1D-myo-inositol pentakisphosphate + H2O = 1D-myo-inositol hexakisphosphate + phosphate.


inositol tetrakisphosphate 1-kinase activity

Catalysis of the reaction: 1D-myo-inositol 3,4,5,6-tetrakisphosphate + ATP = 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ADP.


inositol diphosphate tetrakisphosphate diphosphatase activity

Catalysis of the reaction: diphospho-1D-myo-inositol tetrakisphosphate + H2O = 1D-myo-inositol pentakisphosphate + phosphate.


Catalysis of the reaction: 1D-myo-inositol 3,4,6-trisphosphate + ATP = 1D-myo-inositol 1,3,4,6-tetrakisphosphate + ADP + 2 H+.


Catalysis of the reaction: 1D-myo-inositol 1,3,4-trisphosphate + ATP = 1D-myo-inositol 1,3,4,6-tetrakisphosphate + ADP + 2 H+.


Catalysis of the reaction: ATP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate = ADP + diphospho-1D-myo-inositol tetrakisphosphate. The isomeric configuration of diphospho-1D-myo-inositol tetrakisphosphate is unknown.


inositol diphosphate tetrakisphosphate kinase activity

Catalysis of the reaction: ATP + inositol diphosphate tetrakisphosphate = ADP + inositol bisdiphosphate trisphosphate.


inositol heptakisphosphate kinase activity

Catalysis of the reaction: ATP + diphospho-1D-myo-inositol-pentakisphosphate = ADP + bis(diphospho)-1D-myo-inositol-tetrakisphosphate. The isomeric configurations of the diphospho-1D-myo-inositol-pentakisphosphate (PP-IP5) and bis(diphospho)-1D-myo-inositol-tetrakisphosphate (bis-PP-IP4) are unknown.


inositol 5-diphosphate pentakisphosphate 5-kinase activity

Catalysis of the reaction: ATP + inositol 5-diphosphate pentakisphosphate = ADP + inositol 5-triphosphate pentakisphosphate.


inositol bisdiphosphate tetrakisphosphate diphosphatase activity

Catalysis of the reaction: bisdiphospho-1D-myo-inositol tetrakisphosphate + H2O = diphospho-1D-myo-inositol pentakisphosphate + phosphate.


Catalysis of the reaction: inositol-1,3,4,5,6-pentakisphosphate + H2O = inositol-3,4,5,6-tetrakisphosphate + phosphate.


Catalysis of the reaction: 1D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O = 1D-myo-inositol 1,3,4-trisphosphate + phosphate.


Catalysis of the reaction: inositol-1,3,4,6-tetrakisphosphate + H2O = inositol-1,3,4-trisphosphate + phosphate.


Catalysis of the reaction: inositol-1,3,4,6-tetrakisphosphate + H2O = inositol-3,4,6-trisphosphate + phosphate.


Catalysis of the reaction: 1D-myo-inositol 1,4-bisphosphate + H2O = 1D-myo-inositol 4-phosphate + phosphate.


inositol monophosphate 3-phosphatase activity

Catalysis of the reaction: myo-inositol 3-phosphate + H2O = myo-inositol + phosphate.


Catalysis of the reaction: D-myo-inositol 1,3,4-trisphosphate + H2O = myo-inositol 3,4-bisphosphate + phosphate.


inositol oxygenase activity

Catalysis of the reaction: myo-inositol + O2 = D-glucuronate + H2O + H+.


inositol-3-phosphate synthase activity

Catalysis of the reaction: D-glucose 6-phosphate = 1D-myo-inositol 3-phosphate. This reaction requires NAD, which dehydrogenates the CHOH group to CO at C-5 of the glucose 6-phosphate, making C-6 into an active methylene, able to condense with the aldehyde at C-1. Finally, the enzyme-bound NADH reconverts C-5 into the CHOH form.


Catalysis of the reaction: 1D-myo-inositol 3,4-bisphosphate + H2O = 1D-myo-inositol 3-phosphate + phosphate.


Catalysis of the reaction: 1D-myo-inositol 1,4,5-trisphosphate + H2O = 1D-myo-inositol 1,4-bisphosphate + phosphate.


inositol monophosphate 4-phosphatase activity

Catalysis of the reaction: myo-inositol 4-phosphate + H2O = myo-inositol + phosphate.


Catalysis of the reaction: D-myo-inositol 1,3,4-trisphosphate + H2O = myo-inositol 1,3-bisphosphate + phosphate.


RNA methyltransferase activity

Catalysis of the transfer of a methyl group from a donor to a nucleoside residue in an RNA molecule.


dimethylallyltranstransferase activity

Catalysis of the reaction: dimethylallyl diphosphate + isopentenyl diphosphate = diphosphate + geranyl diphosphate.


glutathione dehydrogenase (ascorbate) activity

Catalysis of the reaction: dehydroascorbate + 2 glutathione = L-ascorbate + glutathione disulfide.


ribosylnicotinamide kinase activity

Catalysis of the reaction: N-ribosylnicotinamide + ATP = ADP + 2 H+ + nicotinamide mononucleotide.


ribosylnicotinate kinase activity

Catalysis of the reaction: N-ribosylnicotinate + ATP = ADP + 2 H+ + nicotinate mononucleotide.


NAD+ kinase activity

Catalysis of the reaction: ATP + NAD+ = ADP + 2 H+ + NADP+.


Catalysis of the reaction: diphosphate + nicotinate D-ribonucleotide = 5-phospho-alpha-D-ribose 1-diphosphate + H+ + nicotinate.


Catalysis of the reaction: 5-formyltetrahydrofolate + ATP = 5,10-methenyltetrahydrofolate + ADP + H+ + phosphate.


Catalysis of the reaction: 5,10-methenyltetrahydrofolate + H2O = 10-formyltetrahydrofolate.


methylenetetrahydrofolate dehydrogenase [NAD(P)+] activity

Catalysis of the reaction: 5,10-methylenetetrahydrofolate + NAD(P)+ = 5,10-methenyltetrahydrofolate + NAD(P)H + H+.


folate reductase activity

Catalysis of the reaction: 7,8-dihydrofolate + NADP+ = folate + NADPH + H+.


Catalysis of the reaction: CoA + substrate-serine = adenosine 3',5'-bisphosphate + substrate-serine-4'-phosphopantetheine. The transfer of the 4'-phosphopantetheine (Ppant) co-factor from coenzyme A to the hydroxyl side chain of the serine residue of acyl- or peptidyl-carrier protein (ACP or PCP) to convert them from the apo to the holo form.


ribonuclease III activity

Catalysis of the endonucleolytic cleavage of RNA with 5'-phosphomonoesters and 3'-OH termini; makes two staggered cuts in both strands of dsRNA, leaving a 3' overhang of 2 nt.


nitric oxide dioxygenase activity

Catalysis of the reaction: 2 NO + 2 O2 + NADPH + H+ = 2 nitrate + NADP+.


deoxyhypusine monooxygenase activity

Catalysis of the reaction: protein N6-(4-aminobutyl)-L-lysine + donor-H2 + O2 = protein N6-((R)-4-amino-2-hydroxybutyl)-L-lysine + acceptor + H2O.


fatty acid elongase activity

Catalysis of the reaction: fatty acid (C-16 or longer) + 2-C = fatty acid (C-16 or longer with an additional 2-C unit). This reaction is the condensation step of the endoplasmic reticulum fatty acid elongation cycle.


Catalysis of the reaction: S-adenosyl-L-methionine + phenylethanolamine = S-adenosyl-L-homocysteine + N-methylphenylethanolamine.


S-methyltransferase activity

Catalysis of the transfer of a methyl group to the sulfur atom of an acceptor molecule.


Catalysis of the reaction: acetyl-CoA + an aralkylamine = CoA + an N-acetylaralkylamine.


glutamine synthetase activity

Catalysis of the reaction: ATP + L-glutamate + NH4+ = ADP + H+ + L-glutamine + phosphate.


hepoxilin-epoxide hydrolase activity

Catalysis of the reaction: (5Z,9E,14Z)-(8x,11R,12S)-11,12-epoxy-8-hydroxyicosa-5,9,14-trienoate + H2O = (5Z,9E,14Z)-(8x,11x,12S)-8,11,12-trihydroxyicosa-5,9,14-trienoate.


dihydronicotinamide riboside quinone reductase activity

Catalysis of the reaction: 1-(beta-D-ribofuranosyl)-1,4-dihydronicotinamide + a quinone = 1-(beta-D-ribofuranosyl)nicotinamide + a hydroquinone.


hepoxilin A3 synthase activity

Catalysis of the reaction: 12S-5Z,8Z,10E,14Z-12-hydro(pero)xy-eicosa-5,8,10,14-tetraenoic acid = (5Z,9E,14Z)-(8,11R,12S)-11,12-epoxy-8-hydroxyicosa-5,9,14-trienoate. 12S-5Z,8Z,10E,14Z-12-hydro(pero)xy-eicosa-5,8,10,14-tetraenoic acid is also known as 12S-HpETE, and (5Z,9E,14Z)-(8,11R,12S)-11,12-epoxy-8-hydroxyicosa-5,9,14-trienoate as hepoxilin A3.


Catalysis of the reaction: NAD(P)+ + (15S)-15-hydroxy-5,8,11-cis-13-trans-icosatetraenoate = NAD(P)H + H+ + 15-oxo-5,8,11-cis-13-trans-icosatetraenoate.


arachidonate 15-lipoxygenase activity

Catalysis of the reaction: arachidonate + O2 = (5Z,8Z,11Z,13E)-(15S)-15-hydroperoxyicosa-5,8,11,13-tetraenoate.


13-lipoxin reductase activity

Definition: Catalysis of the reaction: 15-oxolipoxin A4 + NAD(P)H + H+ = 13,14-dihydro-15-oxolipoxin A4 + NAD(P)+.


N6-methyl-AMP deaminase activity

Catalysis of the reaction: H+ + H2O + N6-methyl-AMP = IMP + methylamine. Can also use N6-methyl-dAMP as a substrate.


nucleoside phosphotransferase activity

Catalysis of the reaction: a nucleotide + a 2'-deoxynucleoside = a nucleoside + a 2'-deoxynucleoside 5'-monophosphate.


nucleoside monophosphate kinase activity

Catalysis of the reaction: ATP + nucleoside monophosphate = ADP + nucleoside diphosphate.


prostaglandin H2 endoperoxidase reductase activity

Catalysis of the reaction: prostaglandin H2 + NADPH + H+ -> prostaglandin F2alpha + NADP+. This reaction is the reduction of prostaglandin H2 ((5Z,13E)-(15S)-9alpha,11alpha-Epidioxy-15-hydroxyprosta-5,13-dienoate) to prostaglandin F2alpha ((5Z,13E)-(15S)-9alpha,11alpha,15-Trihydroxyprosta-5,13-dienoate).


13-prostaglandin reductase activity

Catalysis of the reaction: 15-keto-prostaglandin + NAD(P)H + H+ -> 13,14-dihydro-15-keto-prostaglandin + NAD(P)+. This reaction is the reduction of 15-keto-prostaglandin.


prostaglandin-E2 9-reductase activity

Catalysis of the reaction: (5Z,13E)-(15S)-9-alpha,11-alpha,15-trihydroxyprosta-5,13-dienoate + NADP+ = (5Z,13E)-(15S)-11-alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate + NADPH.


prostaglandin D2 11-ketoreductase activity

Catalysis of the reaction: prostaglandin D2 + H+ + NADPH = 11-epi-prostaglandin F2alpha + NADP+.


prostaglandin-E synthase activity

Catalysis of the reaction: prostaglandin H(2) = prostaglandin E(2).


selenodiglutathione-disulfide reductase (NADP) activity

Catalysis of the reaction: H+ + selenodiglutathione + NADPH = gluthathioselenol + glutathione + NADP+.


selenomethionine-tRNA ligase activity

Catalysis of the reaction: ATP + L-selenomethionine + tRNA(Met) => AMP + diphosphate + selenomethionyl-tRNA(Met).


8-oxo-dGDP phosphatase activity

Catalysis of the reaction 8-oxo-dGDP + H2O = 8-oxo-dGMP + phosphate.


2-hydroxy-dATP hydrolase activity

Catalysis of the reaction: 2-hydroxy-dATP + H2O = 2-hydroxy-dAMP + H+ + diphosphate.


8-hydroxy-dADP phosphatase activity

Catalysis of the reaction: 8-hydroxy-dADP + H2O = 8-hydroxy-dAMP + phosphate.


8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity

Catalysis of the reaction: 8-oxo-7,8-dihydrodeoxyguanosine-triphosphate (8-oxo-dGTP) + H2O = 8-oxo-7,8-dihydrodeoxyguanosine phosphate (8-oxo-dGMP) + diphosphate. 8-oxo-dGTP is the oxidised form of the free guanine nucleotide and can act as a potent mutagenic substrate for DNA synthesis causing transversion mutations. 8-oxo-dGTPase hydrolyses 8-oxo-dGTP to its monophosphate form to prevent the misincorporation of 8-oxo-dGTP into cellular DNA.


8-oxo-GDP phosphatase activity

Catalysis of the reaction 8-oxo-GDP + H2O = 8-oxo-GMP + phosphate.


8-oxo-(d)RTP hydrolase activity

Catalysis of the reaction: 8-oxo-(d)RTP + H20 = 8-oxo-(d)RMP + diphosphate + H+.


2-hydroxy-ATP hydrolase activity

Catalysis of the reaction: 2-hydroxy-ATP + H2O = 2-hydroxy-AMP + H+ + diphosphate.


adenosylselenohomocysteinase activity

Catalysis of the reaction: Se-Adenosyl-L-selenohomocysteine + H2O => Adenosine + Selenohomocysteine.


methylselenol reductase activity

Catalysis of the reaction: NADPH + H+ + CH3SeOH => NADP+ + CH3SeH + H2O.


selenol Se-methyltransferase activity

Catalysis of the reaction: R + Se-Adenosylselenomethionine => CH3-R + Se-Adenosyl-L-selenohomocysteine.


selenite reductase activity

Catalysis of the reaction: SeO3(2-) + 3NADPH + 5H+ = H2Se + 3NADP+ + 3H2O.


Catalysis of the reaction: L-Serine + Selenohomocysteine => L-Selenocystathionine + H2O.


Catalysis of the reaction: ATP + L-Selenomethionine + H2O => Orthophosphate + Diphosphate + Se-Adenosylselenomethionine.


selenomethionine gamma-lyase activity

Catalysis of the reaction: L-Selenomethionine + H2O => Methaneselenol + Ammonia + 2-oxobutanoic acid.


Catalysis of the reaction: L-Selenocystathionine + H2O => L-Selenocysteine + NH3 + 2-Oxobutanoic acid.


Catalysis of the reaction: Se-Methyl-L-selenocysteine + H2O => pyruvic acid + NH3 + Methaneselenol.


hydrogen selenide methyltransferase activity

Catalysis of the reaction: S-adenosyl-L-methionine + hydrogen selenide => S-adenosyl-L-homocysteine + methaneselenol.


selenocysteine lyase activity

Catalysis of the reaction: L-selenocysteine + reduced acceptor = hydrogen selenide + L-alanine + acceptor.


methylselenol demethylase activity

Catalysis of the reaction: methylselenol + H2O => H2Se + CH3OH.


adenylylselenate kinase activity

Catalysis of the reaction: ATP + adenylylselenate => ADP + 3'-phosphoadenylylselenate.


Catalysis of the reaction: 3'-phosphoadenylylselenate + NADPH => adenosine 3',5'-bisphosphate + selenite + NADP+ + H+.


selenate adenylyltransferase (ATP) activity

Catalysis of the reaction: ATP + H2SeO4 => diphosphate + adenylylselenate.


Catalysis of the reaction: S-adenosyl-L-methionine + methaneselenol => S-adenosyl-L-homocysteine + dimethyl selenide.


dimethyl selenide methyltransferase activity

Catalysis of the reaction: S-adenosyl-L-methionine + dimethyl selenide => S-adenosyl-L-homocysteine + trimethylselenonium.


O-phosphoseryl-tRNA(Sec) selenium transferase activity

Catalysis of the reaction: O-phosphoseryl-tRNA(Sec) + selenophosphoric acid + H2O => L-selenocysteinyl-tRNA(Sec) + 2 phosphoric acid.


Catalysis of the reaction: Ser-tRNA(Sec) + ATP = Sep-tRNA(Sec) + ADP.


selenocysteine-tRNA ligase activity

Catalysis of the reaction: tRNASec + L-Ser + ATP = Ser-tRNASec + AMP + diphosphate.


glycine N-acyltransferase activity

Catalysis of the reaction: acyl-CoA + glycine = CoA + N-acylglycine.


histone H3 methyltransferase activity

Catalysis of the reaction: S-adenosyl-L-methionine + a histone H3 = S-adenosyl-L-homocysteine + a methylated histone H3. Histone methylation generally occurs on either an arginine or a lysine residue.


iron-sulfur transferase activity

Catalysis of the transfer of a iron-sulfur cluster from one compound (donor) to another (acceptor).


inorganic diphosphate phosphatase activity

Catalysis of the reaction: diphosphate + H2O = H+ + 2 phosphate.


glutamate-tRNA ligase activity

Catalysis of the reaction: ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu).


valine-tRNA ligase activity

Catalysis of the reaction: L-valine + ATP + tRNA(Val) = L-valyl-tRNA(Val) + AMP + diphosphate + 2 H+.


alanine-tRNA ligase activity

Catalysis of the reaction: ATP + L-alanine + tRNA(Ala) = AMP + diphosphate + L-alanyl-tRNA(Ala).


phenylalanine-tRNA ligase activity

Catalysis of the reaction: ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + L-phenylalanyl-tRNA(Phe).


histidine-tRNA ligase activity

Catalysis of the reaction: ATP + L-histidine + tRNA(His) = AMP + diphosphate + L-histidyl-tRNA(His).


leucine-tRNA ligase activity

Catalysis of the reaction: L-leucine + ATP + tRNA(Leu) = AMP + diphosphate + 2 H+ + Leu-tRNA(Leu).


lysine-tRNA ligase activity

Catalysis of the reaction: ATP + L-lysine + tRNA(Lys) = AMP + diphosphate + L-lysyl-tRNA(Lys).


threonine-tRNA ligase activity

Catalysis of the reaction: ATP + L-threonine + tRNA(Thr) = AMP + diphosphate + L-threonyl-tRNA(Thr).


cysteine-tRNA ligase activity

Catalysis of the reaction: ATP + L-cysteine + tRNA(Cys) = AMP + diphosphate + L-cysteinyl-tRNA(Cys).


asparagine-tRNA ligase activity

Catalysis of the reaction: L-asparagine + ATP + tRNA(Asn) = AMP + Asn-tRNA(Asn) + diphosphate + 2 H+.


proline-tRNA ligase activity

Catalysis of the reaction: ATP + L-proline + tRNA(Pro) = AMP + diphosphate + L-prolyl-tRNA(Pro).


arginine-tRNA ligase activity

Catalysis of the reaction: ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg).


Catalysis of the reaction: RMP + diphosphate = R + 5-phospho-alpha-D-ribose 1-diphosphate.


argininosuccinate synthase activity

Catalysis of the reaction: ATP + L-citrulline + L-aspartate = AMP + diphosphate + (N(omega)-L-arginino)succinate.


glycine N-methyltransferase activity

Catalysis of the reaction: S-adenosyl-L-methionine + glycine = S-adenosyl-L-homocysteine + sarcosine.


myosin phosphatase activity

Catalysis of the reaction: phosphomyosin + H2O = myosin + phosphate.


Catalysis of the reaction: N-acylneuraminate 9-phosphate + H2O = N-acylneuraminate + phosphate.


Catalysis of the reaction: UDP-N-acetyl-D-glucosamine = UDP-N-acetyl-D-mannosamine.


beta-adrenergic receptor kinase activity

Catalysis of the reaction: ATP + beta-adrenergic receptor = ADP + phospho-beta-adrenergic receptor.


RNA exonuclease activity, producing 5'-phosphomonoesters

Catalysis of the hydrolysis of ester linkages within ribonucleic acids by removing nucleotide residues from the 3' or 5' end to yield 5' phosphomonoesters.


RNA exonuclease activity

Catalysis of the sequential cleavage of mononucleotides from a free 5' or 3' terminus of an RNA molecule.


myosin light chain kinase activity

Catalysis of the reaction: ATP + myosin-light-chain = ADP + myosin-light-chain phosphate.


Catalysis of the reaction: N-acetyl-D-glucosamine 6-phosphate + H2O = D-glucosamine 6-phosphate + acetate.


Catalysis of the reaction: N-acetyl-alpha-D-glucosamine 1-phosphate + UTP = diphosphate + UDP-N-acetyl-alpha-D-glucosamine.


methylseleninic acid reductase activity

Catalysis of the reaction: NADPH + H+ + CH3SeO2H => NADP+ + CH3SeOH + H2O.


Catalysis of the endohydrolysis of the N,N'-diacetylchitobiosyl unit in high-mannose glycopeptides and glycoproteins containing the -[Man(GlcNAc)2]Asn-structure. One N-acetyl-D-glucosamine residue remains attached to the protein; the rest of the oligosaccharide is released intact.


diphthine-ammonia ligase activity

Catalysis of the reaction: ATP + diphthine + NH4 = ADP + diphthamide + H+ + phosphate.


protein methylesterase activity

Catalysis of the reaction: protein amino acid methyl ester + H2O = protein amino acid + methanol.


Catalysis of the reaction S-adenosyl-L-methionine + L-histidine-[translation elongation factor 2] = S-methyl-5-thioadenosine + 2-[(3S)-3-amino-3-carboxypropyl]-L-histidine-[translation elongation factor 2].


diphthine synthase activity

Catalysis of the reaction: S-adenosyl-L-methionine + 2-(3-carboxy-3-aminopropyl)-L-histidine = S-adenosyl-L-homocysteine + 2-(3-carboxy-3-(methylammonio)propyl)-L-histidine.


nucleoside kinase activity

Catalysis of the reaction: ATP + nucleoside = ADP + nucleoside monophosphate.


CTP synthase activity

Catalysis of the reaction: ATP + UTP + glutamine + H20= ADP + phosphate + CTP + glutamate.


dCMP deaminase activity

Catalysis of the reaction: dCMP + H2O = dUMP + NH3.


dCTP diphosphatase activity

Catalysis of the reaction: dCTP + H2O = dCMP + H+ + diphosphate.


Catalysis of the reaction: S-substituted L-cysteine + acetyl-CoA = S-substituted N-acetyl-L-cysteine + CoA + H+.


Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing 2'-O-methylguanosine.


tRNA dihydrouridine synthase activity

Catalysis of the reaction: tRNA-uracil + acceptor = tRNA-dihydrouridine + reduced acceptor.


nucleotidyltransferase activity

Catalysis of the transfer of a nucleotidyl group to a reactant.


Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing 2'-O-methyluracil.


Catalysis of the reaction: S-adenosyl-L-methionine + tRNA containing guanine = S-adenosyl-L-homocysteine + tRNA containing N2-methylguanine.


fucokinase activity

Catalysis of the reaction: L-fucose + ATP = beta-L-fucose 1-phosphate + ADP + 2 H+.


Catalysis of the reaction: beta-L-fucose 1-phosphate + GTP + H+ = diphosphate + GDP-beta-L-fucose.


Catalysis of the reaction: 3-phospho-D-glyceroyl phosphate + alpha-D-glucose 1-phosphate = 3-phospho-D-glycerate + alpha-D-glucose 1,6-bisphosphate + H+.


glycerol-3-phosphatase activity

Catalysis of the reaction: glycerol 3-phosphate + H2O = glycerol + phosphate.


Catalysis of the reaction: 2-oxoglutarate + L-alanine = L-glutamate + pyruvate.


argininosuccinate lyase activity

Catalysis of the reaction: N-(L-arginino)succinate = fumarate + L-arginine.


urocanate hydratase activity

Catalysis of the reaction: 4-imidazolone-5-propanoate + H+ = trans-urocanate + H2O.


hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides

Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a cyclic amide.


histamine N-methyltransferase activity

Catalysis of the reaction: S-adenosyl-L-methionine(1+) + histamine = N(tau)-methylhistamine + S-adenosyl-L-homocysteine + H+.


carnosine N-methyltransferase activity

Catalysis of the reaction: S-adenosyl-L-methionine + carnosine = S-adenosyl-L-homocysteine + anserine + H+.


Catalysis of the reaction: L-kynurenine + 2-oxoglutarate = 4-(2-aminophenyl)-2,4-dioxobutanoate + L-glutamate.


Catalysis of the reaction: H2O + NAD+ + 2-aminomuconate semialdehyde = NADH + 2-amino-muconate.


arylformamidase activity

Catalysis of the reaction: N-formyl-L-kynurenine + H2O = formate + L-kynurenine.


kynureninase activity

Catalysis of the reaction: L-kynurenine + H2O = anthranilate + L-alanine.


kynurenine 3-monooxygenase activity

Catalysis of the reaction: L-kynurenine + H+ + NADPH + O2 = 3-hydroxy-L-kynurenine + H2O + NADP+.


deoxyribose-phosphate aldolase activity

Catalysis of the reaction: 2-deoxy-D-ribose 5-phosphate = D-glyceraldehyde 3-phosphate + acetaldehyde.


sedoheptulokinase activity

Catalysis of the reaction: ATP + sedoheptulose = ADP + 2 H+ + sedoheptulose 7-phosphate.


phosphopentomutase activity

Catalysis of the reaction: D-ribose 1-phosphate = D-ribose 5-phosphate.


Catalysis of the reaction: S-adenosyl-L-methionine + protein L-glutamine = S-adenosyl-L-homocysteine + protein N-methyl-L-glutamine.


pentosyltransferase activity

Catalysis of the transfer of a pentosyl group from one compound (donor) to another (acceptor).


ITP diphosphatase activity

Catalysis of the reaction: ITP + H2O = IMP + H+ + diphosphate.


XTP diphosphatase activity

Catalysis of the reaction: XTP + H2O = XMP + H+ + diphosphate.


myristoyltransferase activity

Catalysis of the transfer of a myristoyl (CH3-[CH2]12-CO-) group to an acceptor molecule.


Catalysis of the reaction: acyl-[acyl-carrier protein] + H2O = [acyl-carrier protein] + a fatty acid.


palmitoyl hydrolase activity

Catalysis of a hydrolase reaction that removes a palmitoyl moiety from some substrate.


Catalysis of the reaction: (R)-3-hydroxybutanoate + NAD+ = acetoacetate + H+ + NADH.


Catalysis of the reaction: (S)-3-hydroxy-3-methylglutaryl-CoA = acetoacetate + acetyl-CoA.


acetoacetate-CoA ligase activity

Catalysis of the reaction: acetoacetate + ATP + CoA = acetoacetyl-CoA + AMP + diphosphate + H+.


hydro-lyase activity

Catalysis of the cleavage of a carbon-oxygen bond by elimination of water.


glutamate decarboxylase activity

Catalysis of the reaction: L-glutamate = 4-aminobutanoate + CO2.


protein-glycine ligase activity

Catalysis of the reaction: ATP + glycine + L-glutamyl-[protein] = ADP + glycyl-L-glutamyl-[protein] + H+ + phosphate.


Catalysis of the reaction: L-tyrosine + 2-oxoglutarate = 4-hydroxyphenylpyruvate + L-glutamate.


homogentisate 1,2-dioxygenase activity

Catalysis of the reaction: homogentisate + O2 = 4-maleylacetoacetate + H+.


Catalysis of the reaction: (6R)-6-(L-erythro-1,2-dihydroxypropyl)-5,6,7,8-tetrahydro-4a-hydroxypterin = (6R)-6-(L-erythro-1,2-dihydroxypropyl)-7,8-dihydro-6H-pterin + H2O.


beta-aspartyl-peptidase activity

Catalysis of the cleavage of a beta-linked aspartic residue from the N-terminus of a polypeptide.


Catalysis of the reaction: pyruvate + L-phenylalanine = phenylpyruvate + L-alanine.


Catalysis of the reaction: L-glutamine + pyruvate = 2-oxoglutaramate + L-alanine.


Catalysis of the reaction: L-proline + NADP+ = 1-pyrroline-5-carboxylate + NADPH + H+.


oligoribonucleotidase activity

Catalysis of the exonucleolytic cleavage of oligoribonucleotides to yield ribonucleoside 5'-phosphates.


phospholipid-hydroperoxide glutathione peroxidase activity

Catalysis of the reaction: a hydroperoxy polyunsaturated fatty acid + 2 glutathione = a hydroxy polyunsaturated fatty acid + glutathione disulfide + H2O.


NADPH dehydrogenase activity

Catalysis of the reaction: NADPH + H+ + acceptor = NADP+ + reduced acceptor.


D-serine ammonia-lyase activity

Catalysis of the reaction: D-serine = pyruvate + NH3.


Catalysis of the reaction: O-phospho-L-serine + 2-oxoglutarate = 3-phosphonooxypyruvate + L-glutamate.


threonine-type endopeptidase activity

Catalysis of the hydrolysis of internal peptide bonds in a polypeptide chain by a mechanism in which the hydroxyl group of a threonine residue at the active center acts as a nucleophile.


sulfiredoxin activity

Catalysis of the reaction: peroxiredoxin-(S-hydroxy-S-oxocysteine) + ATP + 2 R-SH = peroxiredoxin-(S-hydroxycysteine) + ADP + phosphate + R-S-S-R.


Catalysis of the reaction: 4-aminobutanoate + 2-oxoglutarate = succinate semialdehyde + L-glutamate.


succinate-semialdehyde dehydrogenase [NAD(P)+] activity

Catalysis of the reaction: succinate semialdehyde + NAD(P)+ + H2O = succinate + NAD(P)H + H+.


acetoacetyl-CoA reductase activity

Catalysis of the reaction: (R)-3-hydroxyacyl-CoA + NADP+ = 3-oxoacyl-CoA + NADPH + H+.


very-long-chain enoyl-CoA reductase activity

Catalysis of the reaction: a very-long-chain 2,3-saturated fatty acyl-CoA + NADP+ = a very-long-chain (2E)-enoyl-CoA + H+ + NADPH.


allantoicase activity

Catalysis of the reaction: allantoate + H2O = (S)-ureidoglycolate + urea.


allantoinase activity

Catalysis of the reaction: allantoin + H2O = allantoate.


ureidoglycolate lyase activity

Catalysis of the reaction: (S)-ureidoglycolate = glyoxylate + urea.


allophanate hydrolase activity

Catalysis of the reaction: H2O + 3 H+ + urea-1-carboxylate = 2 CO2 + 2 NH4.


urea carboxylase activity

Catalysis of the reaction: ATP + bicarbonate + urea = ADP + 2 H+ + phosphate + urea-1-carboxylate.


Catalysis of the reaction: 4-amino-4-deoxychorismate = 4-aminobenzoate + H+ + pyruvate.


Catalysis of the reaction: L-glutamine + chorismate = 4-amino-4-deoxychorismate + L-glutamate. It is composed of two enzymatic activities (which may be present on one or two polypeptides); the first is a glutaminase which yields ammonia from glutamine, releasing glutamate. The ammonia is used by the second activity which catalyzes the amination of chorismate to form 4-amino-4-deoxychorismate.


chitin deacetylase activity

Catalysis of the reaction: chitin + H2O = chitosan + acetate.


trehalose-phosphatase activity

Catalysis of the reaction: trehalose 6-phosphate + H2O = trehalose + phosphate.


alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity

Catalysis of the reaction: UDP-glucose + D-glucose-6-phosphate = UDP + alpha,alpha-trehalose-6-phosphate.


Hydron

The general name for the hydrogen nucleus, to be used without regard to the hydrogen nuclear mass (either for hydrogen in its natural abundance or where it is not desired to distinguish between the isotopes).


An acyl-CoA(4-) that is the tetraanion of acetyl-CoA, arising from deprotonation of the phosphate and diphosphate OH groups.


PUR2_HUMAN Trifunctional purine biosynthetic protein adenosine-3 (sprot)

A trifunctional purine biosynthetic protein adenosine-3 that is encoded in the genome of human.


MMAD_HUMAN Cobalamin trafficking protein CblD (sprot)

A cobalamin trafficking protein CblD that is encoded in the genome of human.


5NT1A_HUMAN Cytosolic 5'-nucleotidase 1A (sprot)

A cytosolic 5'-nucleotidase 1A that is encoded in the genome of human.


MTRR_HUMAN Methionine synthase reductase (sprot)

A methionine synthase reductase that is encoded in the genome of human.


MMAC_HUMAN Cyanocobalamin reductase / alkylcobalamin dealkylase (sprot)

A cyanocobalamin reductase / alkylcobalamin dealkylase that is encoded in the genome of human.


Pentaanion of malonyl-CoA arising from deprotonation of phosphate, diphosphate and carboxylic acid functions.


A hydroxybenzoate that is obtained by removal of a proton from the carboxylic acid group of 6-methylsalicylic acid.


Conjugate base of L-2-aminoadipic acid.


An L-alpha-amino acid zwitterion obtained by transfer of a proton from the carboxy to the amino group of L-valine; major species at pH 7.3.


Conjugate base of N-[(5S)-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine.


Cysteine

An optically active form of cysteine having L-configuration.


isopenicillin N(1-)

Conjugate base of isopenicillin N.


Competence and sporulation factor

A pentapeptide zwitterion resulting from transfer of protons from the carboxy to the amino groups of L-glutamyl-L-arginyl-glycyl-L-methionyl-L-threonine; major species at pH 7.3. It is a quorum-sensing molecule secreted by Bacillus subtilis.


ninein isoform m4 (mouse)

A ninein (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q61043-4.


ATP-dependent (S)-NAD(P)H-hydrate dehydratase isoform 2 (mouse)

An ATP-dependent (S)-NAD(P)H-hydrate dehydratase (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9CZ42-2.


PANK2_MOUSE Pantothenate kinase 2, mitochondrial (sprot)

A pantothenate kinase 2, mitochondrial that is encoded in the genome of mouse.


pantothenate kinase 1 isoform 2 (mouse)

A pantothenate kinase 1 isoform 2 that is encoded in the genome of mouse.


HYES_HUMAN Bifunctional epoxide hydrolase 2 (sprot)

An epoxide hydrolase 2 that is encoded in the genome of human.


NOS3_HUMAN Nitric oxide synthase 3 (sprot)

A nitric oxide synthase, endothelial that is encoded in the genome of human.


BCR_HUMAN Breakpoint cluster region protein (sprot)

A breakpoint cluster region protein that is encoded in the genome of human.


5NT3A_HUMAN Cytosolic 5'-nucleotidase 3A (sprot)

A cytosolic 5'-nucleotidase 3A that is encoded in the genome of human.


CDD_HUMAN Cytidine deaminase (sprot)

A cytidine deaminase that is encoded in the genome of human.


UPP2_HUMAN Uridine phosphorylase 2 (sprot)

A uridine phosphorylase 2 that is encoded in the genome of human.


HS71A_HUMAN Heat shock 70 kDa protein 1A (sprot)

A heat shock 70 kDa protein 1A that is encoded in the genome of human.


deoxyguanosine kinase, mitochondrial isoform m2 (mouse)

A deoxyguanosine kinase, mitochondrial (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9QX60-2.


PPP6_HUMAN Serine/threonine-protein phosphatase 6 catalytic subunit (sprot)

A serine/threonine-protein phosphatase 6 catalytic subunit that is encoded in the genome of human.


PRDX1_HUMAN Peroxiredoxin-1 (sprot)

A peroxiredoxin-1 that is encoded in the genome of human.


NLRP6_HUMAN NACHT, LRR and PYD domains-containing protein 6 (sprot)

A NACHT, LRR and PYD domains-containing protein 6 that is encoded in the genome of human.


CASP4_HUMAN Caspase-4 (sprot)

A caspase-4 that is encoded in the genome of human.


E2AK4_HUMAN eIF-2-alpha kinase GCN2 (sprot)

An eIF-2-alpha kinase GCN2 that is encoded in the genome of human.


DPP9_HUMAN Dipeptidyl peptidase 9 (sprot)

A dipeptidyl peptidase 9 that is encoded in the genome of human.


SLN12_HUMAN Ribonuclease SLFN12 (sprot)

A ribonuclease SLFN12 that is encoded in the genome of human.


PDE3A_HUMAN cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A (sprot)

A cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A that is encoded in the genome of human.


TTLL1_HUMAN Polyglutamylase complex subunit TTLL1 (sprot)

A polyglutamylase complex subunit TTLL1 that is encoded in the genome of human.


PUR4_HUMAN Phosphoribosylformylglycinamidine synthase (sprot)

A phosphoribosylformylglycinamidine synthase that is encoded in the genome of human.


KCY_HUMAN UMP-CMP kinase (sprot)

A UMP-CMP kinase that is encoded in the genome of human.


GLCTK_HUMAN Glycerate kinase (sprot)

A glycerate kinase that is encoded in the genome of human.


A 6-phosphogluconolactonase that is encoded in the genome of human.


XYLB_HUMAN Xylulose kinase (sprot)

A xylulose kinase that is encoded in the genome of human.


STALP_HUMAN AMSH-like protease (sprot)

An AMSH-like protease that is encoded in the genome of human.


PATG_PENEN 6-methylsalicylic acid decarboxylase (sprot)


PATN_PENEN Isoepoxydon dehydrogenase patN (sprot)


PATD_PENEN Alcohol dehydrogenase patD (sprot)


PATF_PENEN Patulin biosynthesis cluster protein F (sprot)


PATK_PENEN 6-methylsalicylic acid synthase (sprot)


PAR16_HUMAN Protein mono-ADP-ribosyltransferase PARP16 (sprot)

A protein mono-ADP-ribosyltransferase PARP16 that is encoded in the genome of human.


SIR2_HUMAN NAD-dependent protein deacetylase sirtuin-2 (sprot)

An NAD-dependent protein deacetylase sirtuin-2 that is encoded in the genome of human.


MPAG2_PENBR O-methyltransferase mpaG' (sprot)


MPAC2_PENBR Non-reducing polyketide synthase mapC' (sprot)


CASPA_HUMAN Caspase-10 (sprot)

A caspase-10 that is encoded in the genome of human.


ACVA_PENCH N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valine synthase (sprot)


IPNA_PENCH Isopenicillin N synthase (sprot)


AFLK_ASPPU Versicolorin B synthase (sprot)


NADA_ASPPU NADH-dependent flavin oxidoreductase nadA (sprot)


AFLM_ASPPU Versicolorin reductase 1 (sprot)


AFLH_ASPPU 5'-hydroxyaverantin dehydrogenase (sprot)


AFLP_ASPPU Sterigmatocystin 8-O-methyltransferase (sprot)


TPH1_HUMAN Tryptophan 5-hydroxylase 1 (sprot)

A tryptophan 5-hydroxylase 1 that is encoded in the genome of human.


PEX7_HUMAN Peroxisomal targeting signal 2 receptor (sprot)

A peroxisomal targeting signal 2 receptor that is encoded in the genome of human.


peroxisomal targeting signal 1 receptor isoform h1 (human)

A peroxisomal targeting signal 1 receptor (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P50542-1.


MET18_HUMAN Histidine protein methyltransferase 1 homolog (sprot)

A histidine protein methyltransferase 1 homolog that is encoded in the genome of human.


GET3_HUMAN ATPase GET3 (sprot)

An ATPase GET3 that is encoded in the genome of human.


PRD16_HUMAN Histone-lysine N-methyltransferase PRDM16 (sprot)

A histone-lysine N-methyltransferase PRDM16 that is encoded in the genome of human.


XPP1_HUMAN Xaa-Pro aminopeptidase 1 (sprot)

An Xaa-Pro aminopeptidase 1 that is encoded in the genome of human.


HSP7C_HUMAN Heat shock cognate 71 kDa protein (sprot)

A heat shock cognate 71 kDa protein that is encoded in the genome of human.


UBP21_HUMAN Ubiquitin carboxyl-terminal hydrolase 21 (sprot)

A ubiquitin carboxyl-terminal hydrolase 21 that is encoded in the genome of human.


ATG4B_HUMAN Cysteine protease ATG4B (sprot)

A cysteine protease ATG4B that is encoded in the genome of human.


ATG4C_HUMAN Cysteine protease ATG4C (sprot)

A cysteine protease ATG4C that is encoded in the genome of human.


ATG4A_HUMAN Cysteine protease ATG4A (sprot)

A cysteine protease ATG4A that is encoded in the genome of human.


NMT1_HUMAN Glycylpeptide N-tetradecanoyltransferase 1 (sprot)

A glycylpeptide N-tetradecanoyltransferase 1 that is encoded in the genome of human.


DELE1_HUMAN DAP3-binding cell death enhancer 1 (sprot)

A DAP3-binding cell death enhancer 1 that is encoded in the genome of human.


UAP1_HUMAN UDP-N-acetylhexosamine pyrophosphorylase (sprot)

A UDP-N-acetylhexosamine pyrophosphorylase that is encoded in the genome of human.


RHG22_HUMAN Rho GTPase-activating protein 22 (sprot)

A Rho GTPase-activating protein 22 that is encoded in the genome of human.


RHG39_HUMAN Rho GTPase-activating protein 39 (sprot)

A Rho GTPase-activating protein 39 that is encoded in the genome of human.


OPHN1_HUMAN Oligophrenin-1 (sprot)

An oligophrenin-1 that is encoded in the genome of human.


PIN1_HUMAN Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (sprot)

A peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 that is encoded in the genome of human.


BMX_HUMAN Cytoplasmic tyrosine-protein kinase BMX (sprot)

A cytoplasmic tyrosine-protein kinase BMX that is encoded in the genome of human.


HSP72_HUMAN Heat shock-related 70 kDa protein 2 (sprot)

A heat shock-related 70 kDa protein 2 that is encoded in the genome of human.


SPEE_HUMAN Spermidine synthase (sprot)

A spermidine synthase that is encoded in the genome of human.


MTNA_HUMAN Methylthioribose-1-phosphate isomerase (sprot)

A methylthioribose-1-phosphate isomerase that is encoded in the genome of human.


SPSY_HUMAN Spermine synthase (sprot)

A spermine synthase that is encoded in the genome of human.


NAMPT_HUMAN Nicotinamide phosphoribosyltransferase (sprot)

A nicotinamide phosphoribosyltransferase that is encoded in the genome of human.


spermine oxidase isoform 3 (human)

A spermine oxidase isoform 3 that is encoded in the genome of human.


ELNE_HUMAN Neutrophil elastase (sprot)

A neutrophil elastase that is encoded in the genome of human.


KGP2_HUMAN cGMP-dependent protein kinase 2 (sprot)

A cGMP-dependent protein kinase 2 that is encoded in the genome of human.


PLPL9_HUMAN 85/88 kDa calcium-independent phospholipase A2 (sprot)

An 85/88 kDa calcium-independent phospholipase A2 that is encoded in the genome of human.


GPCP1_HUMAN Glycerophosphocholine phosphodiesterase GPCPD1 (sprot)

A glycerophosphocholine phosphodiesterase GPCPD1 that is encoded in the genome of human.


CATG_HUMAN Cathepsin G (sprot)

A cathepsin G that is encoded in the genome of human.


MTMR2_HUMAN Myotubularin-related protein 2 (sprot)

A myotubularin-related protein 2 that is encoded in the genome of human.


MTMR5_HUMAN Myotubularin-related protein 5 (sprot)

A myotubularin-related protein 5 that is encoded in the genome of human.


OSBP1_HUMAN Oxysterol-binding protein 1 (sprot)

An oxysterol-binding protein 1 that is encoded in the genome of human.


CLAT_HUMAN Choline O-acetyltransferase (sprot)

A choline O-acetyltransferase that is encoded in the genome of human.


ARY1_HUMAN Arylamine N-acetyltransferase 1 (sprot)

An arylamine N-acetyltransferase 1 that is encoded in the genome of human.


ARY2_HUMAN Arylamine N-acetyltransferase 2 (sprot)

An arylamine N-acetyltransferase 2 that is encoded in the genome of human.


NNMT_HUMAN Nicotinamide N-methyltransferase (sprot)

A nicotinamide N-methyltransferase that is encoded in the genome of human.


TPMT_HUMAN Thiopurine S-methyltransferase (sprot)

A thiopurine S-methyltransferase that is encoded in the genome of human.


AS3MT_HUMAN Arsenite methyltransferase (sprot)

An arsenite methyltransferase that is encoded in the genome of human.


COMT_HUMAN Catechol O-methyltransferase (sprot)

A catechol O-methyltransferase that is encoded in the genome of human.


folylpolyglutamate synthase, mitochondrial isoform h2 (human)

A folylpolyglutamate synthase, mitochondrial (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q05932-2.


AK1A1_HUMAN Aldo-keto reductase family 1 member A1 (sprot)

An aldo-keto reductase family 1 member A1 that is encoded in the genome of human.


BPNT1_HUMAN 3'(2'),5'-bisphosphate nucleotidase 1 (sprot)

A 3'(2'),5'-bisphosphate nucleotidase 1 that is encoded in the genome of human.


ABHEB_HUMAN Putative protein-lysine deacylase ABHD14B (sprot)

A putative protein-lysine deacylase ABHD14B that is encoded in the genome of human.


BAAT_HUMAN Bile acid-CoA:amino acid N-acyltransferase (sprot)

A bile acid-CoA:amino acid N-acyltransferase that is encoded in the genome of human.


TSTD1_HUMAN Thiosulfate:glutathione sulfurtransferase (sprot)

A thiosulfate:glutathione sulfurtransferase that is encoded in the genome of human.


FMO1_HUMAN Flavin-containing monooxygenase 1 (sprot)

A flavin-containing monooxygenase 1 that is encoded in the genome of human.


KT3K_HUMAN Ketosamine-3-kinase (sprot)

A ketosamine-3-kinase that is encoded in the genome of human.


A fructosamine-3-kinase that is encoded in the genome of human.


MTMR7_HUMAN Myotubularin-related protein 7 (sprot)

A myotubularin-related protein 7 that is encoded in the genome of human.


MTM1_HUMAN Myotubularin (sprot)

A myotubularin that is encoded in the genome of human.


NEUR2_HUMAN Sialidase-2 (sprot)

A sialidase-2 that is encoded in the genome of human.


CPTP_HUMAN Ceramide-1-phosphate transfer protein (sprot)

A ceramide-1-phosphate transfer protein that is encoded in the genome of human.


GBA3_HUMAN Cytosolic beta-glucosidase (sprot)

A cytosolic beta-glucosidase that is encoded in the genome of human.


GLTP_HUMAN Glycolipid transfer protein (sprot)

A glycolipid transfer protein that is encoded in the genome of human.


NTRK1_HUMAN High affinity nerve growth factor receptor (sprot)

A high affinity nerve growth factor receptor that is encoded in the genome of human.


MTMR6_HUMAN Myotubularin-related protein 6 (sprot)

A myotubularin-related protein 6 that is encoded in the genome of human.


SPHK2_HUMAN Sphingosine kinase 2 (sprot)

A sphingosine kinase 2 that is encoded in the genome of human.


SPHK1_HUMAN Sphingosine kinase 1 (sprot)

A sphingosine kinase 1 that is encoded in the genome of human.


TNAP3_HUMAN Tumor necrosis factor alpha-induced protein 3 (sprot)

A tumor necrosis factor alpha-induced protein 3 that is encoded in the genome of human.


CC14A_HUMAN Dual specificity protein phosphatase CDC14A (sprot)

A dual specificity protein phosphatase CDC14A that is encoded in the genome of human.


CSK_HUMAN Tyrosine-protein kinase CSK (sprot)

A tyrosine-protein kinase CSK that is encoded in the genome of human.


cAMP-specific 3',5'-cyclic phosphodiesterase 4B isoform hPDE4B3 (human)

A cAMP-specific 3',5'-cyclic phosphodiesterase 4B (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q07343-3.


IPPK_HUMAN Inositol-pentakisphosphate 2-kinase (sprot)

An inositol-pentakisphosphate 2-kinase that is encoded in the genome of human.


PTN3_HUMAN Tyrosine-protein phosphatase non-receptor type 3 (sprot)

A tyrosine-protein phosphatase non-receptor type 3 that is encoded in the genome of human.


HEM4_HUMAN Uroporphyrinogen-III synthase (sprot)

A uroporphyrinogen-III synthase that is encoded in the genome of human.


TGS1_HUMAN Trimethylguanosine synthase (sprot)

A trimethylguanosine synthase that is encoded in the genome of human.


DHB11_HUMAN Estradiol 17-beta-dehydrogenase 11 (sprot)

An estradiol 17-beta-dehydrogenase 11 that is encoded in the genome of human.


CP19A_HUMAN Aromatase (sprot)

An aromatase that is encoded in the genome of human.


S5A2_HUMAN 3-oxo-5-alpha-steroid 4-dehydrogenase 2 (sprot)

A 3-oxo-5-alpha-steroid 4-dehydrogenase 2 that is encoded in the genome of human.


MAGD1_HUMAN Melanoma-associated antigen D1 (sprot)

A melanoma-associated antigen D1 that is encoded in the genome of human.


AK1D1_HUMAN Aldo-keto reductase family 1 member D1 (sprot)

An aldo-keto reductase family 1 member D1 that is encoded in the genome of human.


PMVK_HUMAN Phosphomevalonate kinase (sprot)

A phosphomevalonate kinase that is encoded in the genome of human.


HMCS1_HUMAN Hydroxymethylglutaryl-CoA synthase, cytoplasmic (sprot)

A hydroxymethylglutaryl-CoA synthase, cytoplasmic that is encoded in the genome of human.


ALDR_HUMAN Aldo-keto reductase family 1 member B1 (sprot)

An aldo-keto reductase family 1 member B1 that is encoded in the genome of human.


BPL1_HUMAN Biotin--protein ligase (sprot)

A biotin--protein ligase that is encoded in the genome of human.


FAD1_HUMAN FAD synthase (sprot)

An FAD synthase that is encoded in the genome of human.


NRK2_HUMAN Nicotinamide riboside kinase 2 (sprot)

A nicotinamide riboside kinase 2 that is encoded in the genome of human.


NADC_HUMAN Nicotinate-nucleotide pyrophosphorylase [carboxylating] (sprot)

A nicotinate-nucleotide pyrophosphorylase [carboxylating] that is encoded in the genome of human.


NRK1_HUMAN Nicotinamide riboside kinase 1 (sprot)

A nicotinamide riboside kinase 1 that is encoded in the genome of human.


MP2K5_HUMAN Dual specificity mitogen-activated protein kinase kinase 5 (sprot)

A dual specificity mitogen-activated protein kinase kinase 5 that is encoded in the genome of human.


MTHFS_HUMAN 5-formyltetrahydrofolate cyclo-ligase (sprot)

A 5-formyltetrahydrofolate cyclo-ligase MTHFS that is encoded in the genome of human.


DYR2_HUMAN Dihydrofolate reductase 2, mitochondrial (sprot)

A dihydrofolate reductase 2, mitochondrial that is encoded in the genome of human.


ADPPT_HUMAN L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase (sprot)

An L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase that is encoded in the genome of human.


UBP34_HUMAN Ubiquitin carboxyl-terminal hydrolase 34 (sprot)

A ubiquitin carboxyl-terminal hydrolase 34 that is encoded in the genome of human.


RN146_HUMAN E3 ubiquitin-protein ligase RNF146 (sprot)

An E3 ubiquitin-protein ligase RNF146 that is encoded in the genome of human.


PTN22_HUMAN Tyrosine-protein phosphatase non-receptor type 22 (sprot)

A tyrosine-protein phosphatase non-receptor type 22 that is encoded in the genome of human.


DYN2_HUMAN Dynamin-2 (sprot)

A dynamin-2 that is encoded in the genome of human.


DICER_HUMAN Endoribonuclease Dicer (sprot)

An endoribonuclease Dicer that is encoded in the genome of human.


BN3D2_HUMAN RNA 5'-monophosphate methyltransferase (sprot)

A methyltransferase BCDIN3D that is encoded in the genome of human.


SAR1B_HUMAN GTP-binding protein SAR1b (sprot)

A GTP-binding protein SAR1b that is encoded in the genome of human.


BEX3_HUMAN Protein BEX3 (sprot)

A protein BEX3 that is encoded in the genome of human.


PNMT_HUMAN Phenylethanolamine N-methyltransferase (sprot)

A phenylethanolamine N-methyltransferase that is encoded in the genome of human.


ASMT_HUMAN Acetylserotonin O-methyltransferase (sprot)

An acetylserotonin O-methyltransferase that is encoded in the genome of human.


SNAT_HUMAN Serotonin N-acetyltransferase (sprot)

A serotonin N-acetyltransferase that is encoded in the genome of human.


VGLU1_HUMAN Vesicular glutamate transporter 1 (sprot)

A vesicular glutamate transporter 1 that is encoded in the genome of human.


RHG10_HUMAN Rho GTPase-activating protein 10 (sprot)

A Rho GTPase-activating protein 10 that is encoded in the genome of human.


AL8A1_HUMAN 2-aminomuconic semialdehyde dehydrogenase (sprot)

A 2-aminomuconic semialdehyde dehydrogenase that is encoded in the genome of human.


EST3_HUMAN Carboxylesterase 3 (sprot)

A carboxylesterase 3 that is encoded in the genome of human.


CBR3_HUMAN Carbonyl reductase [NADPH] 3 (sprot)

A carbonyl reductase [NADPH] 3 that is encoded in the genome of human.


CMBL_HUMAN Carboxymethylenebutenolidase homolog (sprot)

A carboxymethylenebutenolidase that is encoded in the genome of human.


AL3A1_HUMAN Aldehyde dehydrogenase, dimeric NADP-preferring (sprot)

An aldehyde dehydrogenase, dimeric NADP-preferring that is encoded in the genome of human.


LOXE3_HUMAN Hydroperoxide isomerase ALOXE3 (sprot)

A hydroperoxide isomerase ALOXE3 that is encoded in the genome of human.


PTGR1_HUMAN Prostaglandin reductase 1 (sprot)

A prostaglandin reductase 1 that is encoded in the genome of human.


MTMR4_HUMAN Myotubularin-related protein 4 (sprot)

A myotubularin-related protein 4 that is encoded in the genome of human.


PPM1A_HUMAN Protein phosphatase 1A (sprot)

A protein phosphatase 1A that is encoded in the genome of human.


AK1C3_HUMAN Aldo-keto reductase family 1 member C3 (sprot)

An aldo-keto reductase family 1 member C3 that is encoded in the genome of human.


CBR1_HUMAN Carbonyl reductase [NADPH] 1 (sprot)

A carbonyl reductase [NADPH] 1 that is encoded in the genome of human.


PXL2B_HUMAN Prostamide/prostaglandin F synthase (sprot)

A prostamide/prostaglandin F synthase that is encoded in the genome of human.


PTGR2_HUMAN Prostaglandin reductase 2 (sprot)

A prostaglandin reductase 2 that is encoded in the genome of human.


8-oxo-dGDP phosphatase NUDT18 isoform 1 (human)

An 8-oxo-dGDP phosphatase NUDT18 isoform 1 that is encoded in the genome of human.


NUDT5_HUMAN ADP-sugar pyrophosphatase (sprot)

An ADP-sugar pyrophosphatase that is encoded in the genome of human.


NUD15_HUMAN Nucleotide triphosphate diphosphatase NUDT15 (sprot)

A nucleotide triphosphate diphosphatase that is encoded in the genome of human.


An adenosylhomocysteinase that is encoded in the genome of human.


INMT_HUMAN Indolethylamine N-methyltransferase (sprot)

An indolethylamine N-methyltransferase that is encoded in the genome of human.


SELB_HUMAN Selenocysteine-specific elongation factor (sprot)

A selenocysteine-specific elongation factor that is encoded in the genome of human.


SPS2_HUMAN Selenide, water dikinase 2 (sprot)

A selenide, water dikinase 2 that is encoded in the genome of human.


ESPL1_HUMAN Separin (sprot)

A separin that is encoded in the genome of human.


histone deacetylase 8 isoform 1 (human)

A histone deacetylase 8 isoform 1 that is encoded in the genome of human.


ACACA_HUMAN Acetyl-CoA carboxylase 1 (sprot)

An acetyl-CoA carboxylase 1 that is encoded in the genome of human.


CMKMT_HUMAN Calmodulin-lysine N-methyltransferase (sprot)

A calmodulin-lysine N-methyltransferase that is encoded in the genome of human.


ANM3_HUMAN Protein arginine N-methyltransferase 3 (sprot)

A protein arginine N-methyltransferase 3 that is encoded in the genome of human.


HDAC6_HUMAN Histone deacetylase 6 (sprot)

A histone deacetylase 6 that is encoded in the genome of human.


DCOR_HUMAN Ornithine decarboxylase (sprot)

An ornithine decarboxylase that is encoded in the genome of human.


AZIN2_HUMAN Antizyme inhibitor 2 (sprot)

An antizyme inhibitor 2 that is encoded in the genome of human.


GLRX1_HUMAN Glutaredoxin-1 (sprot)

A glutaredoxin-1 that is encoded in the genome of human.


CCS_HUMAN Copper chaperone for superoxide dismutase (sprot)

A copper chaperone for superoxide dismutase that is encoded in the genome of human.


peroxiredoxin-5, mitochondrial isoform Cytoplasmic+peroxisomal (human)

A peroxiredoxin-5, mitochondrial (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P30044-2.


SAT1_HUMAN Diamine acetyltransferase 1 (sprot)

A diamine acetyltransferase 1 that is encoded in the genome of human.


DCAM_HUMAN S-adenosylmethionine decarboxylase proenzyme (sprot)

A SAM decarboxylase proenzyme that is encoded in the genome of human.


PTN1_HUMAN Tyrosine-protein phosphatase non-receptor type 1 (sprot)

A tyrosine-protein phosphatase non-receptor type 1 that is encoded in the genome of human.


LYPA2_HUMAN Acyl-protein thioesterase 2 (sprot)

An acyl-protein thioesterase 2 that is encoded in the genome of human.


SYQ_HUMAN Glutamine--tRNA ligase (sprot)

A glutamine--tRNA ligase that is encoded in the genome of human.


GUAA_HUMAN GMP synthase [glutamine-hydrolyzing] (sprot)

A GMP synthase [glutamine-hydrolyzing] that is encoded in the genome of human.


SYEP_HUMAN Bifunctional glutamate/proline--tRNA ligase (sprot)

A bifunctional glutamate/proline--tRNA ligase that is encoded in the genome of human.


SYIC_HUMAN Isoleucine--tRNA ligase, cytoplasmic (sprot)

An isoleucine--tRNA ligase, cytoplasmic that is encoded in the genome of human.


SYMC_HUMAN Methionine--tRNA ligase, cytoplasmic (sprot)

A methionine--tRNA ligase, cytoplasmic that is encoded in the genome of human.


SYVC_HUMAN Valine--tRNA ligase (sprot)

A valine--tRNA ligase that is encoded in the genome of human.


SYRC_HUMAN Arginine--tRNA ligase, cytoplasmic (sprot)

An arginine--tRNA ligase, cytoplasmic that is encoded in the genome of human.


SYLC_HUMAN Leucine--tRNA ligase, cytoplasmic (sprot)

A leucine--tRNA ligase, cytoplasmic that is encoded in the genome of human.


SYAC_HUMAN Alanine--tRNA ligase, cytoplasmic (sprot)

An alanine--tRNA ligase, cytoplasmic that is encoded in the genome of human.


SYNC_HUMAN Asparagine--tRNA ligase, cytoplasmic (sprot)

An asparagine--tRNA ligase, cytoplasmic that is encoded in the genome of human.


HARS1_HUMAN Histidine--tRNA ligase, cytoplasmic (sprot)

A histidyl-tRNA synthetase, cytoplasmic that is encoded in the genome of human.


ACSA_HUMAN Acetyl-coenzyme A synthetase, cytoplasmic (sprot)

An acetyl-coenzyme A synthetase, cytoplasmic that is encoded in the genome of human.


PA24B_HUMAN Cytosolic phospholipase A2 beta (sprot)

A cytosolic phospholipase A2 beta that is encoded in the genome of human.


GFPT1_HUMAN Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1 (sprot)

A glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1 that is encoded in the genome of human.


ADCY3_HUMAN Adenylate cyclase type 3 (sprot)

An adenylate cyclase type 3 that is encoded in the genome of human.


ADCY8_HUMAN Adenylate cyclase type 8 (sprot)

An adenylate cyclase type 8 that is encoded in the genome of human.


DYN1_HUMAN Dynamin-1 (sprot)

A dynamin-1 that is encoded in the genome of human.


FES_HUMAN Tyrosine-protein kinase Fes/Fps (sprot)

A tyrosine-protein kinase Fes/Fps that is encoded in the genome of human.


FARP2_HUMAN FERM, ARHGEF and pleckstrin domain-containing protein 2 (sprot)

A FERM, ARHGEF and pleckstrin domain-containing protein 2 that is encoded in the genome of human.


SIAS_HUMAN Sialic acid synthase (sprot)

A sialic acid synthase that is encoded in the genome of human.