glomerular mesangium development

The process whose specific outcome is the progression of the glomerular mesangium over time, from its formation to the mature structure. The glomerular mesangium is the thin membrane connective tissue composed of mesangial cells, which helps to support the capillary loops in a renal glomerulus.


endochitinase activity

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Catalysis of the hydrolysis of nonterminal (1->4)-beta linkages of N-acetyl-D-glucosamine (GlcNAc) polymers of chitin and chitodextrins. Typically, endochitinases cleave randomly within the chitin chain.


exochitinase activity

Catalysis of the hydrolysis of terminal 1,4-beta-linkages of N-acetyl-D-glucosamine (GlcNAc) polymers of chitin and chitodextrins. Typically, exochitinases progressively cleave off two subunits from the reducing or non-reducing ends of the chitin chain.


ubiquitin-like protein ligase activity

Catalysis of the transfer of a ubiquitin-like protein (ULP) to a substrate protein via the reaction X-ULP + S = X + S-ULP, where X is either an E2 or E3 enzyme, the X-ULP linkage is a thioester bond, and the S-ULP linkage is an isopeptide bond between the C-terminal glycine of ULP and the epsilon-amino group of lysine residues in the substrate.


OFF retinal ganglion cell

biolink:Cell biolink:AnatomicalEntity biolink:OrganismalEntity biolink:BiologicalEntity biolink:NamedThing biolink:PhysicalEssence biolink:SubjectOfInvestigation biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

A retinal ganglion cell that is depolarized by decreased illumination of their receptive field center.


G protein-coupled receptor signaling pathway coupled to cGMP nucleotide second messenger

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The series of molecular signals generated as a consequence of a G protein-coupled receptor binding to its physiological ligand, followed by activation of guanylyl cyclase (GC) activity and a subsequent increase in the concentration of cyclic GMP (cGMP).


regulation of glomerulus development

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Any process that modulates the rate, frequency or extent of glomerulus development, the progression of the glomerulus over time from its initial formation until its mature state. The glomerulus is a capillary tuft surrounded by Bowman's capsule in nephrons of the vertebrate kidney.


proximal tubule development

The process whose specific outcome is the progression of the proximal tubule over time, from its formation to the mature structure. In mammals, the proximal tubule is a nephron tubule that connects Bowman's capsule to the descending thin limb of the loop of Henle. It has a brush border epithelial morphology.


regulation of DNA biosynthetic process

Any process that modulates the frequency, rate or extent of DNA biosynthetic process.


Golgi stack

biolink:CellularComponent biolink:AnatomicalEntity biolink:OrganismalEntity biolink:BiologicalEntity biolink:NamedThing biolink:PhysicalEssence biolink:SubjectOfInvestigation biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

The set of thin, flattened membrane-bounded compartments, called cisternae, that form the central portion of the Golgi complex. The stack usually comprises cis, medial, and trans cisternae; the cis- and trans-Golgi networks are not considered part of the stack.


An organophosphate oxoanion obtained by global deprotonation of the hexaphosphate OH groups of P(1),P(6)-bis(5'-adenosyl)hexaphosphate


Adenosine 5'-tetraphosphate(5-)

An organophosphate oxoanion that is the pentaanionic form of adenosine 5'-tetraphosphate.


tripeptide

Any oligopeptide that consists of three amino-acid residues connected by peptide linkages.


dipeptide zwitterion

Any peptide zwitterion comprising two amino acid residues. Major structure at pH 7.3.


MIP_CHLTR Peptidyl-prolyl cis-trans isomerase Mip (sprot)


regulation of meiosis I

Any process that modulates the rate, frequency, or extent of meiosis I, a cell cycle process comprising the steps by which a cell progresses through the first phase of meiosis, in which cells divide and homologous chromosomes are paired and segregated from each other, producing two daughter cells.


acetyl-CoA catabolic process

The chemical reactions and pathways resulting in the breakdown of acetyl-CoA, a derivative of coenzyme A in which the sulfhydryl group is acetylated.


positive regulation of hematopoietic stem cell migration

Any process that activates or increases the frequency, rate or extent of hematopoietic stem cell migration.


negative regulation of cardioblast differentiation

Any process that stops, prevents, or reduces the frequency, rate or extent of cardioblast differentiation, the process in which a relatively unspecialized mesodermal cell acquires the specialized structural and/or functional features of a cardioblast. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating.


negative regulation of hippo signaling

Any process that stops, prevents, or reduces the frequency, rate or extent of hippo signaling.


fat cell apoptotic process

Any apoptotic process in a fat cell.


response to interleukin-7

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-7 stimulus.


myofibroblast differentiation

The process in which an undifferentiated cell acquires the features of a myofibroblast cell.


regulation of myofibroblast differentiation

Any process that modulates the frequency, rate or extent of myofibroblast differentiation.


response to bleomycin

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a bleomycin stimulus.


lung connective tissue development

The biological process whose specific outcome is the progression of lung connective tissue from an initial condition to its mature state. This process begins with the formation of lung connective tissue and ends with the mature structure. The lung connective tissue is a material made up of fibers forming a framework and support structure for the lungs.


response to interleukin-13

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-13 stimulus.


chemokine (C-C motif) ligand 11 production

The appearance of chemokine (C-C motif) ligand 11 (CCL11, also known as eotaxin-1) due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.


gland morphogenesis

The process in which the anatomical structures of a gland are generated and organized.


positive regulation of smooth muscle cell migration

Any process that activates, maintains or increases the frequency, rate or extent of smooth muscle cell migration.


regulation of nitrogen utilization

Any process that modulates the frequency, rate or extent of nitrogen utilization.


positive regulation of neuron maturation

Any process that activates or increases the frequency, rate or extent of neuron maturation.


negative regulation of calcium ion transport into cytosol

Any process that decreases the rate of the directed movement of calcium ions into the cytosol of a cell. The cytosol is that part of the cytoplasm that does not contain membranous or particulate subcellular components.


leukemia inhibitory factor receptor binding

Binding to an leukemia inhibitory factor receptor.


maternal process involved in female pregnancy

A reproductive process occurring in the mother that allows an embryo or fetus to develop within it.


regulation of RNA polymerase II regulatory region sequence-specific DNA binding

Any process that modulates the frequency, rate or extent of RNA polymerase II regulatory region sequence-specific DNA binding.


spongiotrophoblast differentiation

The process in which a relatively unspecialized cell of the ectoplacental cone acquires specialized features of a spongiotrophoblast of the placenta. A spongiotrophoblast cell is a basophilic cell.


vitamin B6 catabolic process

The chemical reactions and pathways resulting in the breakdown of any of the vitamin B6 compounds; pyridoxal, pyridoxamine and pyridoxine and the active form, pyridoxal phosphate.


Pyridoxal phosphate gamma-aminobutyric acid


heat shock protein binding

Binding to a heat shock protein, a protein synthesized or activated in response to heat shock.


pronephric proximal tubule morphogenesis

The process in which the anatomical structures of a pronephric nephron proximal tubule are generated and organized. A pronephric nephron tubule is an epithelial tube that is part of the pronephros.


Chelerythrine

A benzophenanthridine alkaloid isolated from the root of Zanthoxylum simulans, Chelidonium majus L., and other Papaveraceae.


Azide ion

Any nitrogen molecular entity containing the group -N3.


A dinitrophenol having the nitro groups at the 2- and 4-positions.


The (4R,5S)-isomer of dethiobiotin.


gamma-aminobutyric acid reuptake

The uptake of gamma-aminobutyric acid (GABA, 4-aminobutyrate) by neurons or glial cells. This process leads to inactivation and recycling of neurotransmitters.


potassium ion binding

Binding to a potassium ion (K+).


acetylspermidine deacetylase activity

Catalysis of the reaction: N(8)-acetylspermidine + H2O = acetate + spermidine.


polyamine deacetylation

The modification of acetylpolyamine by the removal of acetyl groups.


spermidine deacetylation

The modification of acetylspermadine by the removal of acetyl groups.


nucleus ambiguus

biolink:AnatomicalEntity biolink:OrganismalEntity biolink:BiologicalEntity biolink:NamedThing biolink:PhysicalEssence biolink:SubjectOfInvestigation biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

A region of histologically disparate cells located just dorsal to the inferior olivary nucleus in the lateral portion of the upper medulla. It receives upper motor neuron innervation directly via the corticobulbar tract This nucleus gives rise to the efferent motor fibers of the vagus nerve terminating in the laryngeal and pharyngeal muscles, as well as to the efferent motor fibers of the glossopharyngeal nerve (CN IX) terminating in the stylopharyngeus. [WP,unvetted].


GTP 3',8'-cyclase activity

Catalysis of the reaction: GTP=(8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate.


cyclic pyranopterin monophosphate synthase activity

Catalysis of the reaction: (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate = cyclic pyranopterin phosphate + diphosphate.


spliceosomal complex assembly

The aggregation, arrangement and bonding together of a spliceosomal complex, a ribonucleoprotein apparatus that catalyzes nuclear mRNA splicing via transesterification reactions.


regulation of oxygen metabolic process

Any process that modulates the frequency, rate or extent of oxygen metabolic process.


CEACAM1a-2L (mouse)

A carcinoembryonic antigen-related cell adhesion molecule 1 sequence variant CEACAM1a (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P31809-3. This form contains the two copies of the Ig domain and is the version with longer cytoplasmic tail.


ANXA6_HUMAN Annexin A6 (sprot)

An annexin A6 that is encoded in the genome of human.


TRI72_HUMAN Tripartite motif-containing protein 72 (sprot)

A tripartite motif-containing protein 72 that is encoded in the genome of human.


CAV3_HUMAN Caveolin-3 (sprot)

A caveolin-3 that is encoded in the genome of human.


DYSF_HUMAN Dysferlin (sprot)

A dysferlin that is encoded in the genome of human.


cell migration involved in heart development

The orderly movement of a cell from one site to another that will contribute to the progression of the heart over time, from its initial formation, to the mature organ.


MRC1_HUMAN Macrophage mannose receptor 1 (sprot)

A macrophage mannose receptor 1 that is encoded in the genome of human.


MRC2_HUMAN C-type mannose receptor 2 (sprot)

A C-type mannose receptor 2 that is encoded in the genome of human.


CLC4K_HUMAN C-type lectin domain family 4 member K (sprot)

A C-type lectin domain family 4 member K that is encoded in the genome of human.


regulation of action potential firing pattern

Any process that regulates the temporal pattern of a sequence of action potentials in a neuron.


Calcitroic acid

A hydroxycalciol that is calcidiol in which the pro-S hydrogen of calcidiol is replaced by a hydroxy group and the C-23/C-27 unit is replaced by a carboxy group.


HG2A_HUMAN HLA class II histocompatibility antigen gamma chain (sprot)

An MHC class II histocompatibility antigen gamma chain that is encoded in the genome of human.


regulation of lamellipodium assembly

Any process that modulates the rate, frequency or extent of the formation of a lamellipodium, a thin sheetlike extension of the surface of a migrating cell.


myoblast migration involved in skeletal muscle regeneration

The process in which a myoblast migrates along an entire fiber to the site of injury. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers.


An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate.


NADH oxidation

A metabolic process that results in the oxidation of reduced nicotinamide adenine dinucleotide, NADH, to the oxidized form, NAD+.


glycerol-3-phosphate metabolic process

The chemical reactions and pathways involving glycerol-3-phosphate, a phosphoric monoester of glycerol.


response to hepatocyte growth factor

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hepatocyte growth factor stimulus.


uterine epithelium development

The progression of an epithelium of the uterus over time from its initial formation to the mature structure. An epithelium is a tissue that covers the internal or external surfaces of an anatomical structure.


response to 1-oleoyl-sn-glycerol 3-phosphate

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a 1-oleoyl-sn-glycerol 3-phosphate stimulus.


response to epidermal growth factor

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an epidermal growth factor stimulus.


regulation of protein tyrosine kinase activity

Any process that modulates the rate, frequency, or extent of protein tyrosine kinase activity.


iris morphogenesis

The process in which the iris is generated and organized. The iris is an anatomical structure in the eye whose opening forms the pupil. The iris is responsible for controlling the diameter and size of the pupil and the amount of light reaching the retina.


nitric oxide binding

Binding to nitric oxide (NO).


hemangioblast

A pluripotent cell in the yolk sac that can give rise to mesenchymal cells including erythrocytes and endothelial cells.


transmembrane transporter complex

A transmembrane protein complex which enables the transfer of a substance from one side of a membrane to the other.


ATP-gated ion channel activity

Enables the transmembrane transfer of an ion by a channel that opens when ATP has been bound by the channel complex or one of its constituent parts.


CTP binding

Binding to CTP, cytidine 5'-triphosphate.


maintenance of protein complex location

Any process in which a protein complex is maintained in a location and prevented from moving elsewhere. These include sequestration, stabilization to prevent transport elsewhere and the active retrieval of protein complexes that move away.


microspike assembly

Formation of a microspike, a dynamic, actin-rich projection extending from the surface of a migrating animal cell.


negative regulation of phospholipase C activity

Any process that stops, prevents or reduces the frequency, rate or extent of phospholipase C activity.


regulation of chondrocyte development

Any process that modulates the rate, frequency, or extent of the process whose specific outcome is the progression of a chondrocyte over time, from its commitment to its mature state. Chondrocyte development does not include the steps involved in committing a chondroblast to a chondrocyte fate.


An oxysterol that is cholesterol which is substituted by hydroxy groups at the 7alpha and 26 positions.


5beta-Cholestane-3alpha,7alpha,12alpha,24,26-pentol with S-configuration at C-24.


3alpha,7alpha,24-trihydroxy-5beta-cholestan-26-al with S-configuration at C-24.


3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestan-26-al with S-configuration at C-24.


5beta-Cholestane-3alpha,7alpha,24,26-tetrol with S-configuration at C-24.


A cholestanoid that is 5beta-cholestan-26-al substituted by hydroxy groups at positions 3, 7 and 12 respectively.


acid-sensing ion channel 1 isoform m2 (mouse)

An acid-sensing ion channel 1 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q6NXK8-2.


peroxisome inheritance

The acquisition of peroxisomes by daughter cells from the mother cell after replication. In Saccharomyces cerevisiae, the number of peroxisomes cells is fairly constant; a subset of the organelles are targeted and segregated to the bud in a highly ordered, vectorial process. Efficient segregation of peroxisomes from mother to bud is dependent on the actin cytoskeleton, and active movement of peroxisomes along actin filaments is driven by the class V myosin motor protein, Myo2p.


vacuole inheritance

The distribution of vacuoles into daughter cells after mitosis or meiosis, mediated by interactions between vacuoles and the cytoskeleton.


embryonic olfactory bulb interneuron precursor migration

The directed movement of individual interneuron precursors during the embryonic development of the olfactory bulb.


regulation of neuron maturation

Any process that modulates the frequency, rate or extent of neuron maturation, the process leading to the attainment of the full functional capacity of a neuron. This process is independent of morphogenetic change.


cerebral cortex GABAergic interneuron development

The process whose specific outcome is the progression of a cerebral cortex GABAergic interneuron over time, from initial commitment to its fate, to the fully functional differentiated cell.


regulation of ERK5 cascade

Any process that modulates the frequency, rate or extent of signal transduction mediated by the ERK5 cascade.


anatomical structure arrangement

The process that gives rise to the configuration of the constituent parts of an anatomical structure. This process pertains to the physical shaping of a rudimentary structure. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome.


GTPase regulator activity

Binds to and modulates the activity of a GTPase.


CAPON_HUMAN Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein (sprot)

A carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein that is encoded in the genome of human.


SRCN1_HUMAN SRC kinase signaling inhibitor 1 (sprot)

A SRC kinase signaling inhibitor 1 that is encoded in the genome of human.


RAC3_HUMAN Ras-related C3 botulinum toxin substrate 3 (sprot)

A Ras-related C3 botulinum toxin substrate 3 that is encoded in the genome of human.


regulation of skeletal muscle acetylcholine-gated channel clustering

Any process that modulates the frequency, rate or extent of skeletal muscle acetylcholine-gated channel clustering.


acetylcholine receptor binding

Binding to an acetylcholine receptor.


regulation of mitotic cell cycle, embryonic

Any process that modulates the frequency, rate or extent of replication and segregation of genetic material in the embryo.


negative regulation of megakaryocyte differentiation

Any process that stops, prevents, or reduces the frequency, rate or extent of megakaryocyte differentiation.


regulation of voltage-gated calcium channel activity

Any process that modulates the frequency, rate or extent of voltage-gated calcium channel activity.


pulmonary artery morphogenesis

The process in which the anatomical structures of the pulmonary artery are generated and organized. The pulmonary artery is the artery that carries blood from the heart to the lungs.


intrahepatic cholangiocyte

An epithelial cell of the intrahepatic portion of the bile duct. These cells are flattened or cuboidal in shape, and have a small nuclear-to-cytoplasmic ratio relative to large/extrahepatic cholangiocytes.


glandular cell of stomach

A glandular epithelial cell that is part of the stomach.


urothelial cell

A cell of a layer of transitional epithelium in the wall of the proximal urethra, bladder, ureter or renal pelvis, external to the lamina propria.


regulation of dendrite extension

Any process that modulates the frequency, rate or extent of dendrite extension.


stereocilia tip-link density

An electron-dense plaque at either end of a stereocilia tip link that provides the anchor in the stereocilia membrane.


ESCRT I complex

An endosomal sorting complex required for transport. It consists of the class E vacuolar protein sorting (Vps) proteins and interacts with ubiquitinated cargoes.


regulation of deacetylase activity

Any process that modulates the frequency, rate or extent of deacetylase activity.


actin crosslink formation

The process in which two or more actin filaments are connected together by proteins that act as crosslinks between the filaments. The crosslinked filaments may be on the same or differing axes.


actin nucleation

The initial step in the formation of an actin filament, in which actin monomers combine to form a new filament. Nucleation is slow relative to the subsequent addition of more monomers to extend the filament.


protein-containing complex remodeling

The acquisition, loss, or modification of macromolecules within a complex, resulting in the alteration of an existing complex.


alpha-tubulin binding

Binding to the microtubule constituent protein alpha-tubulin.


protein deacylation

The removal of an acyl group, any group or radical of the form RCO- where R is an organic group, from a protein amino acid.


Hsp90 deacetylation

The modification of an Hsp90 protein by removal of acetyl groups.


ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway

The chemical reactions and pathways resulting in the breakdown of a protein or peptide covalently tagged with ubiquitin, via the multivesicular body (MVB) sorting pathway; ubiquitin-tagged proteins are sorted into MVBs, and delivered to a lysosome/vacuole for degradation.


cellular response to misfolded protein

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a misfolded protein stimulus.


aggresome assembly

The aggregation, arrangement and bonding together of a set of components to form an aggresome; requires the microtubule cytoskeleton and dynein.


regulation of vascular associated smooth muscle cell proliferation

Any process that modulates the frequency, rate or extent of vascular smooth muscle cell proliferation.


positive regulation of microtubule plus-end binding

Any process that activates or increases the frequency, rate or extent of microtubule plus-end binding.


regulation of cell projection organization

Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell projections.


positive regulation of vascular associated smooth muscle contraction

Any process that activates or increases the frequency, rate or extent of vascular smooth muscle contraction.


endothelial tube lumen extension

Any endothelial tube morphogenesis process by which the tube is increased in length.


negative regulation of cell migration involved in sprouting angiogenesis

Any process that decreases the frequency, rate or extent of cell migration involved in sprouting angiogenesis. Cell migration involved in sprouting angiogenesis is the orderly movement of endothelial cells into the extracellular matrix in order to form new blood vessels contributing to the process of sprouting angiogenesis.


regulation of systemic arterial blood pressure by endothelin

The process in which endothelin modulates the force with which blood passes through the circulatory system. Endothelin is a hormone that is released by the endothelium, and it is a vasoconstrictor.


negative regulation of intracellular steroid hormone receptor signaling pathway

Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of any intracellular steroid hormone receptor signaling pathway.


actomyosin contractile ring

A cytoskeletal structure composed of actin filaments and myosin that forms beneath the plasma membrane of many cells, including animal cells and yeast cells, in a plane perpendicular to the axis of the spindle, i.e. the cell division plane. In animal cells, the contractile ring is located at the cleavage furrow. In budding fungal cells, e.g. mitotic S. cerevisiae cells, the contractile ring forms at the mother-bud neck before mitosis.


neuron projection retraction

The organization process which results in the disassembly (either partial or complete) of constituent parts of a neuron projection. A neuron projection is a prolongation or process extending from a nerve cell, e.g. an axon or dendrite.


negative regulation of neuron projection regeneration

Any process that stops, prevents, or reduces the frequency, rate or extent of neuron projection regeneration, the regrowth of neuronal processes such as axons or dendrites following their loss or damage.


regulation of cellular component size

A process that modulates the size of a cellular component.


profilin binding

Binding to profilin, an actin-binding protein that forms a complex with G-actin and prevents it from polymerizing to form F-actin.


regulation of spindle checkpoint

Any process that modulates the rate, frequency, or extent of the spindle checkpoint, a cell cycle checkpoint that delays the metaphase/anaphase transition until the spindle is correctly assembled and oriented, and chromosomes are attached to the spindle.


negative regulation of sensory perception of pain

Any process that stops, prevents or reduces the frequency, rate or extent of sensory perception of pain.


mastication

The process of biting and mashing food with the teeth prior to swallowing.


catecholamine metabolic process

The chemical reactions and pathways involving any of a group of physiologically important biogenic amines that possess a catechol (3,4-dihydroxyphenyl) nucleus and are derivatives of 3,4-dihydroxyphenylethylamine.


response to corticosterone

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a corticosterone stimulus. Corticosterone is a 21 carbon steroid hormone of the corticosteroid type, produced in the cortex of the adrenal glands. In many species, corticosterone is the principal glucocorticoid, involved in regulation of fuel metabolism, immune reactions, and stress responses.


response to external stimulus

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an external stimulus.


response to dopamine

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a dopamine stimulus.


response to methylphenidate

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methylphenidate stimulus.


cellular response to phosphate starvation

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of phosphate.


negative regulation of catecholamine metabolic process

Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving catecholamine.


benzil reductase [(S)-benzoin-forming] activity

Catalysis of the reaction: (S)-benzoin + NADP(3-) <=> benzil + NADPH(4-) + H+.


regulation of synaptic transmission, dopaminergic

Any process that modulates the frequency, rate or extent of dopaminergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter dopamine.


regulation of norepinephrine secretion

Any process that modulates the frequency, rate or extent of the regulated release of norepinephrine.


inactivation of paternal X chromosome by genomic imprinting

Compensating for the two-fold variation in X-chromosome:autosome ratios between sexes by a global inactivation of all, or most of, the genes on the paternal X-chromosome in the XX sex by genomic imprinting.


regulation of sensory perception of pain

Any process that modulates the frequency, rate or extent of the sensory perception of pain, the series of events required for an organism to receive a painful stimulus, convert it to a molecular signal, and recognize and characterize the signal.


ammonium excretion

The elimination of ammonium ions from an excretory cell.


positive regulation of integrin-mediated signaling pathway

Any process that activates or increases the frequency, rate or extent of integrin-mediated signaling pathway.


negative regulation of integrin-mediated signaling pathway

Any process that stops, prevents or reduces the frequency, rate or extent of integrin-mediated signaling pathway.


cytoplasm protein quality control

The chemical reactions and pathways resulting in the breakdown of misfolded proteins in the cytoplasm, which are either targeted to cytoplasmic proteasomes for degradation or protected by chaperones to shield thermosensitive proteins from degradation until conditions allow disaggregation and refolding.


LUBAC complex

A ubiquitin ligase complex that catalyzes linear head-to-tail polyubiquitin conjugation on its targets. In human the complex consists of RBCK1, RNF31 and SHARPIN, and has an MW of approximately 600 kDa, suggesting a heteromultimeric assembly of its subunits. LUBAC stands for Linear Ubiquitin Chain Assembly Complex.


positive regulation of protein polyubiquitination

Any process that activates or increases the frequency, rate or extent of protein polyubiquitination.


septal nuclear complex

Collection of nerve cells in the medial forebrain lying generally in front of the anterior commissure (Maryann Martone).


SUMO1_HUMAN Small ubiquitin-related modifier 1 (sprot)

A small ubiquitin-related modifier 1 that is encoded in the genome of human.


SUMO2_HUMAN Small ubiquitin-related modifier 2 (sprot)

A small ubiquitin-related modifier 2 that is encoded in the genome of human.


SUMO3_HUMAN Small ubiquitin-related modifier 3 (sprot)

A small ubiquitin-related modifier 3 that is encoded in the genome of human.


IF2B1_HUMAN Insulin-like growth factor 2 mRNA-binding protein 1 (sprot)

An insulin-like growth factor 2 mRNA-binding protein 1 that is encoded in the genome of human.


IF2B3_HUMAN Insulin-like growth factor 2 mRNA-binding protein 3 (sprot)

An insulin-like growth factor 2 mRNA-binding protein 3 that is encoded in the genome of human.


IF2B2_HUMAN Insulin-like growth factor 2 mRNA-binding protein 2 (sprot)

An insulin-like growth factor 2 mRNA-binding protein 2 that is encoded in the genome of human.


DCP1A_HUMAN mRNA-decapping enzyme 1A (sprot)

An mRNA-decapping enzyme 1A that is encoded in the genome of human.


TISB_HUMAN mRNA decay activator protein ZFP36L1 (sprot)

An mRNA decay activator protein ZFP36L1 that is encoded in the genome of human.


TNPO1_HUMAN Transportin-1 (sprot)

A transportin-1 that is encoded in the genome of human.


TTP_HUMAN mRNA decay activator protein ZFP36 (sprot)

An mRNA decay activator protein ZFP36 that is encoded in the genome of human.


PARN_HUMAN Poly(A)-specific ribonuclease PARN (sprot)

A poly(A)-specific ribonuclease PARN that is encoded in the genome of human.


Z385A_HUMAN Zinc finger protein 385A (sprot)

A zinc finger protein 385A that is encoded in the genome of human.


BRD7_HUMAN Bromodomain-containing protein 7 (sprot)

A bromodomain-containing protein 7 that is encoded in the genome of human.


PO4F1_HUMAN POU domain, class 4, transcription factor 1 (sprot)

A POU domain, class 4, transcription factor 1 that is encoded in the genome of human.


IASPP_HUMAN RelA-associated inhibitor (sprot)

A RelA-associated inhibitor that is encoded in the genome of human.


PO4F2_HUMAN POU domain, class 4, transcription factor 2 (sprot)

A POU domain, class 4, transcription factor 2 that is encoded in the genome of human.


BANP_HUMAN Protein BANP (sprot)

A protein BANP that is encoded in the genome of human.


HIPK1_HUMAN Homeodomain-interacting protein kinase 1 (sprot)

A homeodomain-interacting protein kinase 1 that is encoded in the genome of human.


ASPP2_HUMAN Apoptosis-stimulating of p53 protein 2 (sprot)

An apoptosis-stimulating of p53 protein 2 that is encoded in the genome of human.


ASPP1_HUMAN Apoptosis-stimulating of p53 protein 1 (sprot)

An apoptosis-stimulating of p53 protein 1 that is encoded in the genome of human.


sperm mitochondrial sheath assembly

The assembly and organization of the sperm mitochondrial sheath, the tightly packed helical sheath of ATP-producing mitochondria restricted to the midpiece of the sperm flagellum.


Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dopamine(out) + Na+(out) + Cl-(out)= dopamine(in) + Na+(in) + Cl-(in).


TR10D_HUMAN Tumor necrosis factor receptor superfamily member 10D (sprot)

A tumor necrosis factor receptor superfamily member 10D that is encoded in the genome of human.


MSH2_HUMAN DNA mismatch repair protein Msh2 (sprot)

A DNA mismatch repair protein Msh2 that is encoded in the genome of human.


CCNK_HUMAN Cyclin-K (sprot)

A cyclin-K that is encoded in the genome of human.


CDK12_HUMAN Cyclin-dependent kinase 12 (sprot)

A cyclin-dependent kinase 12 that is encoded in the genome of human.


B2L14_HUMAN Apoptosis facilitator Bcl-2-like protein 14 (sprot)

An apoptosis facilitator Bcl-2-like protein 14 that is encoded in the genome of human.


PERP_HUMAN p53 apoptosis effector related to PMP-22 (sprot)

A p53 apoptosis effector related to PMP-22 that is encoded in the genome of human.


PGTA_HUMAN Geranylgeranyl transferase type-2 subunit alpha (sprot)

A geranylgeranyl transferase type-2 subunit alpha that is encoded in the genome of human.


NDRG1_HUMAN Protein NDRG1 (sprot)

A protein NDRG1 that is encoded in the genome of human.


PGTB2_HUMAN Geranylgeranyl transferase type-2 subunit beta (sprot)

A geranylgeranyl transferase type-2 subunit beta that is encoded in the genome of human.


TM219_HUMAN Insulin-like growth factor-binding protein 3 receptor (sprot)

A transmembrane protein 219 that is encoded in the genome of human.


NLRC4_HUMAN NLR family CARD domain-containing protein 4 (sprot)

An NLR family CARD domain-containing protein 4 that is encoded in the genome of human.


GA45A_HUMAN Growth arrest and DNA damage-inducible protein GADD45 alpha (sprot)

A growth arrest and DNA damage-inducible protein GADD45 alpha that is encoded in the genome of human.


BNI3L_HUMAN BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like (sprot)

A BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like that is encoded in the genome of human.


TRIA1_HUMAN TP53-regulated inhibitor of apoptosis 1 (sprot)

A TP53-regulated inhibitor of apoptosis 1 that is encoded in the genome of human.


BTG2_HUMAN Protein BTG2 (sprot)

A protein BTG2 that is encoded in the genome of human.


PLAL1_HUMAN Zinc finger protein PLAGL1 (sprot)

A zinc finger protein PLAGL1 that is encoded in the genome of human.


RGCC_HUMAN Regulator of cell cycle RGCC (sprot)

A response gene to complement 32 protein that is encoded in the genome of human.


E2F8_HUMAN Transcription factor E2F8 (sprot)

A transcription factor E2F8 that is encoded in the genome of human.


ARI3A_HUMAN AT-rich interactive domain-containing protein 3A (sprot)

An AT-rich interactive domain-containing protein 3A that is encoded in the genome of human.


E2F7_HUMAN Transcription factor E2F7 (sprot)

A transcription factor E2F7 that is encoded in the genome of human.


TR10A_HUMAN Tumor necrosis factor receptor superfamily member 10A (sprot)

A tumor necrosis factor receptor superfamily member 10A that is encoded in the genome of human.


TR10B_HUMAN Tumor necrosis factor receptor superfamily member 10B (sprot)

A tumor necrosis factor receptor superfamily member 10B that is encoded in the genome of human.


TR10C_HUMAN Tumor necrosis factor receptor superfamily member 10C (sprot)

A tumor necrosis factor receptor superfamily member 10C that is encoded in the genome of human.


PLD3A_HUMAN PRELI domain containing protein 3A (sprot)

A PRELI domain containing protein 3A that is encoded in the genome of human.


PRLD1_HUMAN PRELI domain-containing protein 1, mitochondrial (sprot)

A PRELI domain-containing protein 1, mitochondrial that is encoded in the genome of human.


early stripe melanocyte differentiation

The process in which a relatively unspecialized cell acquires the specialized features of an early stripe melanocyte (ESM). In zebrafish, ESMs develop during the first phase (2-3 weeks of development) of the larva to adult transition (2-4 weeks of development).


articular chondrocyte

Chondrocyte forming the hyaline cartilage found in joints.


beige adipocyte

A fat cell that is beige in color, thermogenic, and which differentiates in white fat tissue from a Myf5-negative progenitor.


regulation of collagen fibril organization

Any process that modulates the frequency, rate or extent of collagen fibril organization.


muscle system process

A organ system process carried out at the level of a muscle. Muscle tissue is composed of contractile cells or fibers.


extracellular matrix structural constituent conferring tensile strength

A constituent of the extracellular matrix that enables the matrix to resist longitudinal stress.


muscle cell apoptotic process

A form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases, whose actions dismantle a muscle cell and result in its death. A muscle cell is a mature contractile cell, commonly known as a myocyte, that forms one of three kinds of muscle.


mitochondrial transmembrane transport

The process in which a solute is transported from one side of a membrane to the other into, out of or within a mitochondrion.


response to polyamine macromolecule

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a polyamine macromolecule stimulus.


pronephric nephron development

The process whose specific outcome is the progression of the pronephric nephron over time, from its formation to the mature structure. A pronephric nephron is the functional unit of the pronephros.


fetal thymocyte

A thymocyte found in the fetal thymus.


experimentally modified cell in vitro

A cell in vitro that has undergone physical changes as a consequence of a deliberate and specific experimental procedure.


negative regulation of hh target transcription factor activity

Any process that decreases the activity of a transcription factor that activates transcription of Hedgehog-target genes in response to Smoothened signaling. In Drosophila, Cubitus interruptus (Ci) is the only identified transcription factor so far in the Hedgehog signaling pathway. In vertebrates members of the Gli protein family are activated by Hedgehog signaling.


regulation of oligodendrocyte apoptotic process

Any process that modulates the frequency, rate or extent of oligodendrocyte apoptotic process.


smoothened signaling pathway involved in ventral spinal cord patterning

The series of molecular signals generated as a consequence of activation of the transmembrane protein Smoothened that results in the spatial identity of regions along the dorsal-ventral axis of the spinal cord.


Noc1p-Noc2p complex

A heterodimer associated with 90S and 66S preribosomes. Predominantly, but not exclusively, nucleolar; involved in ribosomal large subunit biogenesis.


regulation of apoptotic signaling pathway

Any process that modulates the frequency, rate or extent of apoptotic signaling pathway.


death receptor binding

Binding to a member of the death receptor (DR) family. The DR family falls within the tumor necrosis factor receptor superfamily and is characterized by a cytoplasmic region of ~80 residues termed the death domain (DD).


protein homooligomerization

The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer.


Pyrogallol

A  benzenetriol carrying hydroxy groups at positions 1, 2 and 3.


Caffeic Acid

The trans-isomer of caffeic acid.


Tempo carboxylic acid

A member of the class of aminoxyls that is TEMPO carrying a carboxy group at position 4.


Butin

A trihydroxyflavanone in which the three hydroxy substituents are located at positions 3', 4' and 7. It is found in Acacia mearnsii, Vernonia anthelmintica and Dalbergia odorifera and has a protective affect against oxidative stress-induced mitochondrial dysfunction.


Tempamine

A member of the class of aminoxyls that is TEMPO carrying an amino group at position 4.


A polymer composed of PEG-ylated sorbitan, where the total number of poly(ethylene glycol) units is 20 (w + x + y + z = 20) and a single terminal is capped by an oleoyl group.


tetrapyrrole binding

Binding to a tetrapyrrole, a compound containing four pyrrole nuclei variously substituted and linked to each other through carbons at the alpha position.


protoporphyrinogen IX metabolic process

The chemical reactions and pathways involving protoporphyrinogen IX, the specific substrate for the enzyme ferrochelatase, which catalyzes the insertion of iron to form protoheme. It is probably also the substrate for chlorophyll formation.


regulation of hemoglobin biosynthetic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of hemoglobin, an oxygen carrying, conjugated protein containing four heme groups and globin.


detection of UV

The series of events in which an ultraviolet radiation (UV light) stimulus is received and converted into a molecular signal. Ultraviolet radiation is electromagnetic radiation with a wavelength in the range of 10 to 380 nanometers.


Sodium dodecyl sulfate

An organic sodium salt that is the sodium salt of dodecyl hydrogen sulfate.


Diphenyleneiodonium

An organic cation that is fluorene in which the methylene group is replaced by a positively charged iodine.


Methylene Blue

An organic chloride salt having 3,7-bis(dimethylamino)phenothiazin-5-ium as the counterion. A commonly used dye that also exhibits antioxidant, antimalarial, antidepressant and cardioprotective properties.


Triton X-100

A poly(ethylene glycol) derivative that is poly(ethylene glycol) in which one of the terminal hydroxy groups has been converted into the corresponding p-(2,4,4-trimethylpentan-3-yl)phenyl ether.


Mevalonic acid

The (R)-enantiomer of mevalonic acid.


positive regulation of intracellular protein transport

Any process that activates or increases the frequency, rate or extent of the directed movement of proteins within cells.


entrainment of circadian clock by photoperiod

The synchronization of a circadian rhythm to photoperiod, the intermittent cycle of light (day) and dark (night).


'de novo' GMP biosynthetic process

The chemical reactions and pathways resulting in the formation of guanosine 5'-monophosphate (GMP) through an inosine 5'-monophosphate (IMP) intermediate.


phosphatidylinositol 3-kinase regulatory subunit binding

Binding to a regulatory subunit of phosphatidylinositol 3-kinase. The regulatory subunit associates with the catalytic subunit to regulate both its activity and subcellular location.


protein heterooligomerization

The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of component monomers that are not all identical. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer.


response to glial cell derived neurotrophic factor

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glial cell derived neurotrophic factor stimulus.


neurotrophin signaling pathway

The series of molecular signals initiated by neurotrophin binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. Neurotrophins are a family of secreted growth factors that induce the survival, development, and function of neurons.


Rab protein signal transduction

The series of molecular signals within the cell that are mediated by a member of the Rab family of proteins switching to a GTP-bound active state.


negative regulation of stress-activated MAPK cascade

Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the stress-activated MAPK cascade.


slow muscle cell migration

The orderly movement of a slow muscle cell from one site to another.


cellular biogenic amine catabolic process

The chemical reactions and pathways occurring at the level of individual cells resulting in the breakdown of biogenic amines, any of a group of naturally occurring, biologically active amines, such as norepinephrine, histamine, and serotonin, many of which act as neurotransmitters.


An acyl-sn-glycero-3-phosphate in which a single acyl substituent is located at position 2.


An octadecenoyl-CoA that results from the formal condensation of the thiol group of coenzyme A with the carboxy group of trans-2-octadecenoic acid.


A 3-hydroxy fatty acyl-CoA that results from the formal condensation of the thiol group of coenzyme A with the carboxy group of 3-hydroxyoctadecanoic acid.


A 3-oxo-fatty acyl-CoA(4-) arising from deprotonation of the phosphate and diphosphate groups of 3-oxooctadecanoyl-CoA; major species at pH 7.3.


Tetraanion of icosanoyl-CoA arising from deprotonation of phosphate and diphosphate functions.


sphinganine metabolic process

The chemical reactions and pathways involving sphinganine, D-erythro-2-amino-1,3-octadecanediol.


RACK1_HUMAN Small ribosomal subunit protein RACK1 (sprot)

A receptor of activated protein C kinase 1 that is encoded in the genome of human.


FAN_HUMAN Protein FAN (sprot)

A protein FAN that is encoded in the genome of human.


acyltransferase activity, transferring groups other than amino-acyl groups

Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor).


melanocyte apoptotic process

Any apoptotic process in a melanocyte, the main structural component of the epidermis.


stem cell fate commitment

The process in which the developmental fate of a cell becomes restricted such that it will develop into a stem cell.


swim bladder formation

The process that gives rise to the swim bladder. This process pertains to the initial formation of a structure from unspecified parts. The swim bladder is used by some fishes to maintain buoyancy and may function in addition as a sound producing organ, a sound receptor, and a respiratory organ.


negative regulation of protein sumoylation

Any process that stops, prevents, or reduces the frequency, rate or extent of the addition of SUMO groups to a protein.


outward rectifier potassium channel activity

Enables the transmembrane transfer of a potassium ion by an outwardly-rectifying voltage-gated channel. An outwardly rectifying current-voltage relation is one where at any given driving force the outward flow of K+ ions exceeds the inward flow for the opposite driving force.


cellular response to nerve growth factor stimulus

A process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nerve growth factor stimulus.


regulation of neurotrophin TRK receptor signaling pathway

Any process that modulates the frequency, rate or extent of the neurotrophin TRK receptor signaling pathway.


regulation of trans-synaptic signaling by BDNF, modulating synaptic transmission

Any process that modulates the frequency, rate or extent of trans-synaptic signaling by BDNF, modulating synaptic transmission.


regulation of postsynaptic dense core vesicle exocytosis

Any process that modulates the frequency, rate or extent of postsynaptic dense core vesicle exocytosis.


negative regulation of neurotransmitter secretion

Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of a neurotransmitter.


regulation of neurotransmitter secretion

Any process that modulates the frequency, rate or extent of the regulated release of a neurotransmitter from a cell.


substance P secreting cell

A peptide hormone secreting cell that secretes substance P.


mRNA 5'-splice site recognition

Recognition of the intron 5'-splice site by components of the assembling spliceosome.


regulation of vasoconstriction by circulating norepinephrine

Any process that modulates the frequency, rate or extent of reductions in the diameter of blood vessels as a result of secretion of norepinephrine into the bloodstream.


longitudinal sarcoplasmic reticulum

The portion of the free sarcoplasmic reticulum consisting of longitudinal tubules that connect terminal cisternae.


skeletal muscle adaptation

Any process in which skeletal muscles change their phenotypic profiles in response to altered functional demands and a variety of signals.


regulation of excitatory postsynaptic membrane potential involved in skeletal muscle contraction

Any process, involved in skeletal muscle contraction, that modulates the establishment or extent of the excitatory postsynaptic potential (EPSP). Excitatory postsynaptic potential (EPSP) is a temporay increase in postsynaptic potential due to the flow of positively charged ions into the postsynaptic cell. The flow of ions that causes an EPSP is an excitatory postsynaptic current (EPSC) and makes it easier for the neuron to fire an action potential.


serine phosphorylation of STAT protein

The process of introducing a phosphate group to a serine residue of a STAT (Signal Transducer and Activator of Transcription) protein.


positive regulation of protein targeting to membrane

Any process that increases the frequency, rate or extent of the process of directing proteins towards a membrane, usually using signals contained within the protein.


superior olivary nucleus maturation

A developmental process, independent of morphogenetic (shape) change, that is required for the superior olivary nucleus to attain its fully functional state. The superior olivary nucleus is a small cylindrical mass on the dorsal surface of the lateral part of the trapezoid body of the pons, and it is situated immediately above the inferior olivary nucleus. It receives projections from the cochlear nucleus and thus is involved in the perception of sound.


epinephrine secretion

The regulated release of epinephrine by a cell. Epinephrine is a catecholamine hormone secreted by the adrenal medulla and a neurotransmitter, released by certain neurons and active in the central nervous system.


adrenal chromaffin cell differentiation

The process in which a relatively unspecialized cell acquires specialized structural and/or functional features of an adrenal chromaffin cell. An adrenal chromaffin cell is a neuroendocrine cell that stores epinephrine secretory vesicles.


type I enteroendocrine cell

An enteroendocrine cell commonest in the duodenum and jejunum, rare in ileum, that secretes cholecystokinin. This cell type is involved in the regulation of digestive enzymes and bile.


mitotic spindle midzone

The area in the center of the anaphase spindle consisting of microtubules, microtubule bundling factors and kinesin motors where the spindle microtubules from opposite poles overlap in an antiparallel manner.


mitotic metaphase chromosome alignment

A chromosome localization process whereby chromosomes are positioned in a specific order and orientation at the metaphase plate (spindle equator), during mitotic chromosome segregation. This alignment ensures that each daughter cell will receive the correct number of chromosomes during cell division.


protein complex involved in cell adhesion

Any protein complex that is capable of carrying out some part of the process of cell adhesion to the cell matrix or to another cell.


inducible T-cell costimulator isoform 1 (human)

An inducible T-cell costimulator isoform 1 that is encoded in the genome of human.


TNR14_HUMAN Tumor necrosis factor receptor superfamily member 14 (sprot)

A tumor necrosis factor receptor superfamily member 14 that is encoded in the genome of human.


BTLA_HUMAN B- and T-lymphocyte attenuator (sprot)

A B- and T-lymphocyte attenuator that is encoded in the genome of human.


ICOSL_HUMAN ICOS ligand (sprot)

An ICOS ligand that is encoded in the genome of human.


positive regulation of centriole replication

Any process that activates or increases the frequency, rate or extent of centriole replication.


Myb complex

A multisubunit complex consisting of Myb and other proteins that regulates site specific DNA replication, gene amplification and transcriptional repression.


WW domain-binding protein 5 isoform 1 (mouse)

A transcription elongation factor A protein-like 9 isoform 1 that is encoded in the genome of mouse.


NALCN_HUMAN Sodium leak channel NALCN (sprot)

A sodium leak channel NALCN that is encoded in the genome of human.


neuroblast fate determination

The cell fate determination process in which a cell becomes capable of differentiating autonomously into a neuroblast cell regardless of its environment; upon determination, the cell fate cannot be reversed. An example of this process is found in Mus musculus.


regulation of timing of subpallium neuron differentiation

The process controlling the timing and/or rate at which a relatively unspecialized cell in the subpallium acquires features of a neuron. The subpallium is the base region of the telencephalon.


histone acetyltransferase binding

Binding to an histone acetyltransferase.


glutamate-cysteine ligase complex

An enzyme complex that catalyzes the ligation of glutamate to cysteine, forming glutamylcysteine.


negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway

Any process that stops, prevents or reduces the frequency, rate or extent of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway.


regulation of mitochondrial depolarization

Any process that modulates the frequency, rate or extent of the change in the membrane potential of the mitochondria from negative to positive.


positive regulation of calcium ion-dependent exocytosis

Any process that activates or increases the frequency, rate or extent of calcium ion-dependent exocytosis.


negative regulation of synaptic plasticity

A process that decreases synaptic plasticity, the ability of synapses to change as circumstances require. They may alter function, such as increasing or decreasing their sensitivity, or they may increase or decrease in actual numbers.


negative regulation of protein export from nucleus

Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of proteins from the nucleus into the cytoplasm.


nuclear membrane disassembly

The controlled breakdown of the nuclear membranes, for example during cellular division.


acetylcholine binding

Binding to acetylcholine, an acetic acid ester of the organic base choline that functions as a neurotransmitter, released at the synapses of parasympathetic nerves and at neuromuscular junctions.


platelet alpha granule

A secretory organelle found in blood platelets, which is unique in that it exhibits further compartmentalization and acquires its protein content via two distinct mechanisms: (1) biosynthesis predominantly at the megakaryocyte (MK) level (with some vestigial platelet synthesis) (e.g. platelet factor 4) and (2) endocytosis and pinocytosis at both the MK and circulating platelet levels (e.g. fibrinogen (Fg) and IgG).


cerebellar granular layer morphogenesis

The process in which the anatomical structure of the cerebellar granular layer is generated and organized. The granular layer is the innermost layer of the cerebellar cortex. This layer contains densely packed small neurons, mostly granule cells. Some Golgi cells are found at the outer border. Granule neurons send parallel fibers to the upper molecular layer, where they synapse with Purkinje cell dendrites. Mossy fibers from the pontine nuclei in the white matter synapse with granule cell axons, Golgi cell axons and unipolar brush interneuron axons at cerebellar glomeruli in the granule cell layer.


negative regulation of platelet activation

Any process that decreases the rate or frequency of platelet activation. Platelet activation is a series of progressive, overlapping events triggered by exposure of the platelets to subendothelial tissue.


mating plug formation

The deposition of a plug of sperm or other gelatinous material into the opening of the vulva by a male at the termination of copulation. Probably acts to prevent subsequent matings by other males.


seminal vesicle epithelium development

The progression of the seminal vesicle epithelium over time, from its formation to the mature structure.


regulation of interleukin-1 beta production

Any process that modulates the frequency, rate, or extent of interleukin-1 beta production.


positive regulation of focal adhesion assembly

Any process that activates or increases the frequency, rate or extent of focal adhesion assembly, the establishment and maturation of focal adhesions.


positive regulation of actin nucleation

Any process that activates or increases the frequency, rate or extent of actin nucleation, the initial step in the formation of an actin filament in which actin monomers combine to form a new filament.


ureteric bud invasion

The process in which the ureteric bud grows along its axis and contributes to the formation of the metanephros.


dynamin-1-like protein isoform m2 (mouse)

A dynamin-1-like protein (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q8K1M6-2.


phospholipid catabolic process

The chemical reactions and pathways resulting in the breakdown of phospholipids, any lipid containing phosphoric acid as a mono- or diester.


regulation of phospholipase A2 activity

Any process that modulates the activity of the enzyme phospholipase A2.


regulation of phospholipid catabolic process

Any process that modulates the rate, frequency, or extent of phospholipid catabolism, the chemical reactions and pathways resulting in the breakdown of phospholipids, any lipid containing phosphoric acid as a mono- or diester.


dark adaptation

The process by which the rods of the retina gradually become fully responsive to dim light when no longer exposed to bright light.


heterotrimeric G-protein complex assembly

The aggregation, arrangement and bonding together of a set of components to form a heterotrimeric G-protein complex.


photoreceptor inner segment layer

Layer of the retina composed of the inner segments of the photoreceptor cells.


pyruvate kinase PKM isoform M1 (mouse)

A pyruvate kinase PKM isoform M1 that is encoded in the genome of mouse.


regulation of epidermal cell differentiation

Any process that modulates the frequency, rate or extent of epidermal cell differentiation.


traversing start control point of mitotic cell cycle

A cell cycle process by which a cell commits to entering S phase via a positive feedback mechanism between the regulation of transcription and G1 CDK activity.


MutSalpha complex

A heterodimer involved in the recognition and repair of base-base and small insertion/deletion mismatches. In human the complex consists of two subunits, MSH2 and MSH6.


guanine/thymine mispair binding

Binding to a double-stranded DNA region containing a G/T mispair.


mismatched DNA binding

Binding to a double-stranded DNA region containing one or more mismatches.


negative regulation of DNA recombination

Any process that stops, prevents, or reduces the frequency, rate or extent of DNA recombination.


somatic recombination of immunoglobulin genes involved in immune response

The process in which immunoglobulin genes are formed through recombination of the germline genetic elements, also known as immunoglobulin gene segments, within a single locus following the induction of and contributing to an immune response.


positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator

Any process that activates or increases the frequency, rate or extent of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator.


negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator

Any process that stops, prevents or reduces the frequency, rate or extent of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator.


MSH6_HUMAN DNA mismatch repair protein Msh6 (sprot)

A DNA mismatch repair protein Msh6 that is encoded in the genome of human.


MSH3_HUMAN DNA mismatch repair protein Msh3 (sprot)

A DNA mismatch repair protein Msh3 that is encoded in the genome of human.


STAP2_HUMAN Signal-transducing adaptor protein 2 (sprot)

A signal-transducing adaptor protein 2 that is encoded in the genome of human.


proprioception involved in equilibrioception

The series of events contributing to equilibrioception by which an organism senses the position, location, orientation, and movement of the body and its parts. Proprioception plays an important role in the ability of an organism to perceive its orientation with respect to gravity.


cellular response to interleukin-3

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-3 stimulus.


neural fold bending

The morphogenesis of the neural fold elevations that results in the movement of the tips of the elevations towards each other in order to fuse.


midbrain-hindbrain boundary maturation during brain development

A developmental process occurring after the brain has been specified along the neural axis that is required for the midbrain-hindbrain boundary to attain its fully functional state. The midbrain-hindbrain domain of the embryonic brain is comprised of the mesencephalic vesicle and the first rhombencephalic vesicle at early somitogenesis stages. An organizing center at the boundary patterns the midbrain and hindbrain primordia of the neural plate.


planar cell polarity pathway involved in outflow tract morphogenesis

The series of molecular signals initiated by binding of a Wnt protein to a receptor on the surface of the target cell where activated receptors signal via downstream effectors including C-Jun N-terminal kinase (JNK) to modulate cytoskeletal elements and control cell polarity that contributes to the shaping of the outflow tract.


salivary gland development

The process whose specific outcome is the progression of the salivary gland over time, from its formation to the mature structure. Salivary glands include any of the saliva-secreting exocrine glands of the oral cavity.


glandular epithelial cell development

The process whose specific outcome is the progression of a glandular epithelial cell over time, from its formation to the mature structure. A glandular epithelial cell is a columnar/cuboidal epithelial cell is a cell found in a two dimensional sheet with a free surface exposed to the lumen of a gland.


convergent extension involved in somitogenesis

The morphogenetic process in which a presomitic mesoderm narrows along the left-right axis and lengthens in the rostral-caudal axis contributing to somitogenesis.


tau-protein kinase activity

Catalysis of the reaction: ATP + tau-protein = ADP + O-phospho-tau-protein.


negative regulation of neuron maturation

Any process that stops, prevents, or reduces the frequency, rate or extent of neuron maturation.


positive regulation of peptidyl-threonine phosphorylation

Any process that increases the frequency, rate or extent of peptidyl-threonine phosphorylation. Peptidyl-threonine phosphorylation is the phosphorylation of peptidyl-threonine to form peptidyl-O-phospho-L-threonine.


phosphatidylglycerol metabolic process

The chemical reactions and pathways involving phosphatidylglycerols, any of a class of phospholipids in which the phosphatidyl group is esterified to the hydroxyl group of glycerol. They are important constituents of cell membranes.


cerebellar Purkinje cell layer maturation

A developmental process, independent of morphogenetic (shape) change, that is required for the cerebellar Purkinje cell layer to attain its fully functional state. The Purkinje cell layer lies just underneath the molecular layer of the cerebellar cortex. It contains the neuronal cell bodies of the Purkinje cells that are arranged side by side in a single layer. Candelabrum interneurons are vertically oriented between the Purkinje cells. Purkinje neurons are inhibitory and provide the output of the cerebellar cortex through axons that project into the white matter. Extensive dendritic trees from the Purkinje cells extend upward in a single plane into the molecular layer where they synapse with parallel fibers of granule cells.


inhibition of neuroepithelial cell differentiation

Any process that prevents the activation of neuroepithelial cell differentiation. Neuroepithelial cell differentiation is the process in which epiblast cells acquire specialized features of neuroepithelial cells.


forebrain ventricular zone progenitor cell division

The mitotic division of a basal progenitor giving rise to two neurons.


stomach neuroendocrine cell differentiation

The process in which a relatively unspecialized cell acquires specialized features of a neuroendocrine cell of the stomach epithelium.


lung neuroendocrine cell differentiation

The process in which a relatively unspecialized cell acquires specialized features of a neuroendocrine cell of the lung epithelium.


carotid body glomus cell differentiation

The process in which a relatively unspecialized cell acquires specialized structural and/or functional features of a glomus cell of the carotid body. The carotid body is a specialized chemosensory organ that helps respond to hypoxia.


pituicyte

A glial cell of astrocytic lineage with long processes running parallel to adjacent axons in the proximal infundibulum of the neurohypophysis. These processes form a three-dimensional network among the axons of the hypothalamic neurosecretory cells and are connected by gap junctions which provide for their metabolic coupling. This cell type constitutes most of the nonexcitable tissue in the neurohypophsis; function may include possibly acting as an intermediate in the modulation of oxytocin and vasopressin release. This cell type is highly variable in size and shape and commonly contain lipid droplets and deposits of lipochrome pigment.


APOA_HUMAN Apolipoprotein(a) (sprot)

An apolipoprotein(a) that is encoded in the genome of human.


stimulatory C-type lectin receptor signaling pathway

The series of molecular signals initiated by the binding of C-type lectin to its receptor on the surface of a target cell, and resulting in cellular activation.


natural killer cell inhibitory signaling pathway

The series of molecular signals initiated by an extracellular ligand binding to a receptor on the surface of a natural killer cell capable of inhibiting an immune effector process contributing to an immune response.


intussusceptive angiogenesis

The formation of new blood vessels as a result of the insertion and extension of lumenal tissue pillars.


keratinocyte migration

The directed movement of a keratinocyte, epidermal cells which synthesize keratin, from one site to another.


nuclear receptor binding

Binding to a nuclear receptor protein. Nuclear receptor proteins are DNA-binding transcription factors which are regulated by binding to a ligand.


myosin filament assembly

The aggregation, arrangement and bonding together of a filament composed of myosin molecules.


striated muscle cell apoptotic process

A form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases, whose actions dismantle a striated muscle cell and result in its death. Striated muscle cells make up striated muscle fibers which are divided by transverse bands into striations.


craniofacial suture morphogenesis

The process in which any suture between cranial and/or facial bones is generated and organized.


regulation of forebrain neuron differentiation

Any process that modulates the frequency, rate or extent of forebrain neuron differentiation.


regulation of protein dephosphorylation

Any process that modulates the frequency, rate or extent of removal of phosphate groups from a protein.


myoepithelial cell of mammary gland

A myoepithelial cell that surrounds milk-secreting luminal epithelial cells. This cell type contracts under the stimulation of oxytocin and is attached to the basement membrane by hemidesmosomes and to the adjacent luminal cells by desmosomes. This cell type expresses high level of keratin-14 and is estrogen receptor alpha negative.


calcium ion binding involved in regulation of presynaptic cytosolic calcium ion concentration

The directed change of presynaptic cytosolic free calcium ion concentration in the cytosol via the reversible binding of calcium ions to calcium-binding proteins in the cytosol thereby modulating the spatial and temporal dynamics of changes in presynaptic cytosolic calcium concentrations.


antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent

The process in which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC class I protein complex following intracellular transport via a TAP-dependent ER pathway. The peptide is typically a fragment of a larger endogenous protein which has been degraded within the cell and becomes associated with the MHC class I molecule in the ER following TAP-dependent transport from the cytosol. Class I here refers to classical class I molecules.


protein localization to endoplasmic reticulum exit site

A process in which a protein is transported to, or maintained in, a location at an endoplasmic reticulum exit site.


membrane coat

Any of several different proteinaceous coats that can associate with membranes. Membrane coats include those formed by clathrin plus an adaptor complex, the COPI and COPII complexes, and possibly others. They are found associated with membranes on many vesicles as well as other membrane features such as pits and perhaps tubules.


copper ion transport

The directed movement of copper (Cu) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


5-methylcytosine metabolic process

The chemical reactions and pathways involving 5-methylcytosine, a methylated base of DNA.


basal cortex

The region that lies just beneath the plasma membrane on the basal edge of a cell.


RNA metabolic process

The cellular chemical reactions and pathways involving RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage.


pinocytosis

An endocytosis process that results in the uptake of liquid material by cells from their external environment; literally 'cell drinking'. Liquid is enclosed in vesicles, called pinosomes, formed by invagination of the plasma membrane.


positive regulation of cell-matrix adhesion

Any process that activates or increases the rate or extent of cell adhesion to an extracellular matrix.


squamous basal epithelial stem cell differentiation involved in prostate gland acinus development

The process in which a relatively unspecialized epithelial cell acquires specialized features of a squamous basal epithelial stem cell of the prostate.


type D cell of stomach

A type D cell found in the stomach.


optic fissure

Groove that is in the developing ventral optic cup and through which blood vessels pass to the enclosed mesenchyme[ZFA]. a ventral fissure in the developing optic cup through which blood vessels pass to the enclosed mesenchyme[Free online medical dictionary].


negative regulation of cAMP-dependent protein kinase activity

Any process that stops, prevents or reduces the frequency, rate or extent of cAMP-dependent protein kinase activity.


regulation of corticosterone secretion

Any process that modulates the frequency, rate or extent of corticosterone secretion.


anoikis

Apoptosis triggered by inadequate or inappropriate adherence to substrate e.g. after disruption of the interactions between normal epithelial cells and the extracellular matrix.


soft palate development

The biological process whose specific outcome is the progression of the soft palate from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure, whatever form that may be including its natural destruction. The soft palate is the posterior portion of the palate extending from the posterior edge of the hard palate.


DNA double-strand break processing involved in repair via single-strand annealing

The 5' to 3' exonucleolytic resection of the DNA at the site of the break to form a 3' single-strand DNA overhang that results in the repair of a double strand break via single-strand annealing.


lens fiber cell apoptotic process

Any apoptotic process in a lens fiber cell. Lens fiber cells are elongated, tightly packed cells that make up the bulk of the mature lens in a camera-type eye.


importin-alpha family protein binding

Binding to a member of the importin-alpha family.


alpha DNA polymerase:primase complex

A complex of four polypeptides, comprising large and small DNA polymerase alpha subunits and two primase subunits, which are capable of catalyzing the synthesis of an RNA primer on the lagging strand of replicating DNA and the subsequent synthesis of a smal stretch of DNA. The smaller of the two primase subunits alone can catalyze oligoribonucleotide synthesis.


calcitonin receptor activity

Combining with calcitonin and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex.


late recombination nodule

An electron dense structure that is associated with meiotic chromosomes in pachytene during meiosis I.


meiotic spindle midzone assembly

The formation of the spindle midzone, the area in the center of the spindle where the spindle microtubules from opposite poles overlap, as a part of the process of meiosis.


meiotic metaphase I homologous chromosome alignment

A cell cycle process whereby homlogous chromosomes are positioned in a specific order and orientation at the metaphase plate (spindle equator) by the spindle machinery and centromere/kinetochore arrangement during meiosis I chromosome segregation. This alignment ensures that each daughter cell will receive the correct number of chromosomes during cell division.


triplet codon-amino acid adaptor activity

The codon binding activity of a tRNA that positions an activated amino acid, mediating its insertion at the correct point in the sequence of a nascent polypeptide chain during protein synthesis.


negative regulation of mesenchymal cell proliferation

Any process that decreases the frequency, rate or extent of mesenchymal cell proliferation. A mesenchymal cell is a cell that normally gives rise to other cells that are organized as three-dimensional masses, rather than sheets.


cellular response to cisplatin

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cisplatin stimulus.


AATF_HUMAN Protein AATF (sprot)

A protein AATF that is encoded in the genome of human.


receptor tyrosine-protein kinase erbB-4 isoform JM-B CYT-2 (mouse)

A receptor tyrosine-protein kinase erbB-4 isoform 2 that is encoded in the genome of mouse.


TSC22 domain family protein 1 isoform 2 (mouse)

A TSC22 domain family protein 1 isoform 2 that is encoded in the genome of mouse.


Bcl-2-modifying factor isoform 2 (mouse)

A Bcl-2-modifying factor (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by [LM]DPGAEPWHHNSEAETLSWSHPGE followed by the sequence in UniProtKB:Q91ZE9-1. It is uncertain whether Leu or Met is the starting residue. The authors in PMID:20706276 claim the use of a non-conventional CUG-translation initiation site.


Bcl-2-modifying factor isoform 1 (mouse)

A Bcl-2-modifying factor (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q91ZE9-1.


Bcl-2-like protein 1 isoform Bcl-X(S) (mouse)

A Bcl-2-like protein 1 isoform 2 that is encoded in the genome of mouse.


DLL3_HUMAN Delta-like protein 3 (sprot)

A delta-like protein 3 that is encoded in the genome of human.


NOGG_HUMAN Noggin (sprot)

A noggin that is encoded in the genome of human.


MESP2_HUMAN Mesoderm posterior protein 2 (sprot)

A mesoderm posterior protein 2 that is encoded in the genome of human.


CRUM3_HUMAN Protein crumbs homolog 3 (sprot)

A protein crumbs homolog 3 that is encoded in the genome of human.


PALS1_HUMAN Protein PALS1 (sprot)

A protein PALS1 that is encoded in the genome of human.


INADL_HUMAN InaD-like protein (sprot)

An InaD-like protein that is encoded in the genome of human.


CLD5_HUMAN Claudin-5 (sprot)

A claudin-5 that is encoded in the genome of human.


CLD4_HUMAN Claudin-4 (sprot)

A claudin-4 that is encoded in the genome of human.


CLD11_HUMAN Claudin-11 (sprot)

A claudin-11 that is encoded in the genome of human.


CLD7_HUMAN Claudin-7 (sprot)

A claudin-7 that is encoded in the genome of human.


CLD9_HUMAN Claudin-9 (sprot)

A claudin-9 that is encoded in the genome of human.


CLD14_HUMAN Claudin-14 (sprot)

A claudin-14 that is encoded in the genome of human.


CLD1_HUMAN Claudin-1 (sprot)

A claudin-1 that is encoded in the genome of human.


CLD15_HUMAN Claudin-15 (sprot)

A claudin-15 that is encoded in the genome of human.


CLD6_HUMAN Claudin-6 (sprot)

A claudin-6 that is encoded in the genome of human.


CLD8_HUMAN Claudin-8 (sprot)

A claudin-8 that is encoded in the genome of human.


CLD12_HUMAN Claudin-12 (sprot)

A claudin-12 that is encoded in the genome of human.


CLD17_HUMAN Claudin-17 (sprot)

A claudin-17 that is encoded in the genome of human.


CLD18_HUMAN Claudin-18 (sprot)

A claudin-18 that is encoded in the genome of human.


CLD20_HUMAN Claudin-20 (sprot)

A claudin-20 that is encoded in the genome of human.


CLD2_HUMAN Claudin-2 (sprot)

A claudin-2 that is encoded in the genome of human.


CLD10_HUMAN Claudin-10 (sprot)

A claudin-10 that is encoded in the genome of human.


CLD19_HUMAN Claudin-19 (sprot)

A claudin-19 that is encoded in the genome of human.


CLD22_HUMAN Claudin-22 (sprot)

A claudin-22 that is encoded in the genome of human.


CLD23_HUMAN Claudin-23 (sprot)

A claudin-23 that is encoded in the genome of human.


CLD16_HUMAN Claudin-16 (sprot)

A claudin-16 that is encoded in the genome of human.


negative regulation of T-helper 17 cell differentiation

Any process that stops, prevents or reduces the frequency, rate or extent of T-helper 17 cell differentiation.


MRF binding

Binding to Myogenic Regulatory Factor (MRF), a member of the basic Helix-Loop-Helix (bHLH) superfamily of transcription factors.


cell migration involved in endocardial cushion formation

The orderly movement of a cell from one site to another that will contribute to the formation of an endocardial cushion. The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves.


Fc-gamma receptor signaling pathway

The series of molecular signals initiated by the binding of the Fc portion of immunoglobulin G (IgG) to an Fc-gamma receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. The Fc portion of an immunoglobulin is its C-terminal constant region.


multinuclear osteoclast differentiation

The process in which a relatively unspecialized monocyte acquires the specialized features of a multinuclear osteoclast. An osteoclast is a specialized phagocytic cell associated with the absorption and removal of the mineralized matrix of bone tissue.


positive regulation of cytochrome-c oxidase activity

Any process that activates or increases the frequency, rate or extent of cytochrome-c oxidase activity.


L-amino acid transport

The directed movement of L-enantiomer amino acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


regulation of mammary gland epithelial cell proliferation

Any process that modulates the frequency, rate or extent of mammary gland epithelial cell proliferation.


epithelial cell differentiation involved in mammary gland alveolus development

The process in which a relatively unspecialized epithelial cell becomes a more specialized epithelial cell of the mammary gland alveolus.


superior olivary complex

A collection of brainstem nuclei that functions in multiple aspects of hearing and is an important component of the ascending and descending auditory pathways of the auditory system.


hematopoietic system

Anatomical system that is involved in the production of hematopoietic cells.


The myristoylation of the N-terminal glycine of proteins to form the derivative N-myristoyl-glycine.


N-terminal protein myristoylation

The covalent attachment of a myristoyl group to the N-terminal amino acid residue of a protein.


red nucleus

Large round nucleus located in the midbrain tegmentum, consisting of a magnocellular and parvicellular portion in most species studied.


rhombomere 3 lateral wall

A rhombomere lateral wall that is part of a rhombomere 3.


positive regulation of high voltage-gated calcium channel activity

Any process that activates or increases the frequency, rate or extent of high voltage-gated calcium channel activity.


voltage-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential

Any voltage-gated ion channel activity that is involved in regulation of postsynaptic membrane potential.


lipase activator activity

Binds to and increases the activity of a lipase, an enzyme that catalyzes of the hydrolysis of a lipid.


hormone binding

Binding to an hormone, a naturally occurring substance secreted by specialized cells that affect the metabolism or behavior of cells possessing functional receptors for the hormone. Hormones may be produced by the same, or different, cell as express the receptor.


chondroitin sulfate proteoglycan binding

Binding to a chondroitin sulfate proteoglycan, any proteoglycan containing chondroitin sulfate as the glycosaminoglycan carbohydrate unit.


CSPG2_MOUSE Versican core protein (sprot)

A versican core protein that is encoded in the genome of mouse.


regulation of immune system process

Any process that modulates the frequency, rate, or extent of an immune system process.


olfactory receptor activity

Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell.


Carvone, (+/-)-

A p-menthane monoterpenoid that consists of cyclohex-2-enone having methyl and isopropenyl substituents at positions 2 and 5, respectively.


mitochondrion distribution

Any process that establishes the spatial arrangement of mitochondria between and within cells.


sarcoplasmic reticulum calcium ion transport

The directed movement of calcium ions (Ca2+) into, out of or within the sarcoplasmic reticulum.


kidney proximal convoluted tubule epithelial cell


regulation of CD8-positive, alpha-beta T cell differentiation

Any process that modulates the frequency, rate, or extent of CD8-positive, alpha-beta T cell differentiation.


regulation of guanylate cyclase activity

Any process that modulates the frequency, rate or extent of guanylate cyclase activity.


guanylate cyclase regulator activity

Modulates the activity of guanylate cyclase.


calcium sensitive guanylate cyclase activator activity

Binds to and increases the activity of guanylate cyclase in response to a change in calcium ion concentration.


fatty-acyl-CoA synthase activity

Catalysis of the reaction: acetyl-CoA + n malonyl-CoA + 2n NADH + 2n NADPH + 4n H+ = a long-chain acyl-CoA + n CoA + n CO2 + 2n NAD+ + 2n NADP+.


negative regulation of glucocorticoid biosynthetic process

Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glucocorticoids.


positive regulation of striated muscle contraction

Any process that activates or increases the frequency, rate or extent of striated muscle contraction.


EMAL4_HUMAN Echinoderm microtubule-associated protein-like 4 (sprot)

An echinoderm microtubule-associated protein-like 4 that is encoded in the genome of human.


exonuclease activity

Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' or 5' end.


flap endonuclease activity

Catalysis of the cleavage of a flap structure in DNA, but not other DNA structures; processes the ends of Okazaki fragments in lagging strand DNA synthesis.


manganese ion binding

Binding to a manganese ion (Mn).


mesenchymal stem cell maintenance involved in nephron morphogenesis

The process in which an organism retains a population of mesenchymal stem cells that contributes to the shaping of a nephron. A mesenchymal stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized mesenchymal cells.


adiponectin-activated signaling pathway

The series of molecular signals initiated by adiponectin binding to its receptor on the surface of a cell, and ending with the regulation of a downstream cellular process, e.g. transcription.


corticotrophin-releasing factor receptor activity

Combining with the corticotrophin-releasing factor family of ligands, including the urocortins, to initiate a change in cell activity.


regulation of hair follicle cell proliferation

Any process that modulates the frequency, rate or extent of hair follicle cell proliferation.


positive regulation of cell maturation

Any process that activates or increases the frequency, rate or extent of cell maturation.


negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator

Any process that stops, prevents or reduces the frequency, rate or extent of intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator.


negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress

Any process that stops, prevents or reduces the frequency, rate or extent of intrinsic apoptotic signaling pathway in response to osmotic stress.


planar cell polarity pathway involved in cardiac muscle tissue morphogenesis

The series of molecular signals initiated by binding of a Wnt protein to a receptor on the surface of the target cell where activated receptors signal via downstream effectors including C-Jun N-terminal kinase (JNK) to modulate cytoskeletal elements and control cell polarity that contributes to the shaping of the cardiac muscle tissue.


SUN domain-containing protein 1 isoform m5 (mouse)

A SUN domain-containing protein 1 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9D666-5.


cardiac left ventricle morphogenesis

The process in which the left cardiac ventricle is generated and organized.


fibroblast growth factor production

The appearance of a fibroblast growth factor due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.


positive regulation of fibroblast growth factor production

Any process that increases the rate, frequency or extent of the appearance of a fibroblast growth factor due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.


response to peptide hormone

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptide hormone stimulus. A peptide hormone is any of a class of peptides that are secreted into the blood stream and have endocrine functions in living animals.


myosin heavy chain binding

Binding to a heavy chain of a myosin complex.


MYH6_MOUSE Myosin-6 (sprot)

A myosin-6 that is encoded in the genome of mouse.


MYO19_MOUSE Unconventional myosin-XIX (sprot)

A myosin-XIX that is encoded in the genome of mouse.


activin binding

Binding to activin, a dimer of inhibin-beta subunits.


sperm ejaculation

The expulsion of seminal fluid, thick white fluid containing spermatozoa, from the male genital tract.


activin receptor binding

Binding to an activin receptor.


INHBA_MOUSE Inhibin beta A chain (sprot)

An activin/inhibin beta A chain that is encoded in the genome of mouse.


PTPRF_MOUSE Receptor-type tyrosine-protein phosphatase F (sprot)

A receptor-type tyrosine-protein phosphatase F that is encoded in the genome of mouse.


DUS3_MOUSE Dual specificity protein phosphatase 3 (sprot)

A dual specificity protein phosphatase 3 that is encoded in the genome of mouse.


thioether S-methyltransferase activity

Catalysis of the reaction: S-adenosyl-L-methionine(1+) + dimethyl sulfide = S-adenosyl-L-homocysteine + trimethylsulfonium.


vitamin E biosynthetic process

The chemical reactions and pathways resulting in the formation of vitamin E, tocopherol, which includes a series of eight structurally similar compounds. Alpha-tocopherol is the most active form in humans and is a powerful biological antioxidant.


negative regulation of post-translational protein modification

Any process that stops, prevents or reduces the frequency, rate or extent of post-translational protein modification.


synaptonemal complex organization

A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a synaptonemal complex. A synaptonemal complex is a proteinaceous scaffold formed between homologous chromosomes during meiosis.


positive regulation of reciprocal meiotic recombination

Any process that increases the frequency, rate or extent of recombination during meiosis. Reciprocal meiotic recombination is the cell cycle process in which double strand breaks are formed and repaired through a double Holliday junction intermediate.


histone lysine demethylation

The modification of a histone by the removal of a methyl group from a lysine residue.


melatonin receptor activity

Combining with melatonin, N-acetyl-5-methoxytryptamine, to initiate a change in cell activity. Melatonin is a neuroendocrine substance that stimulates the aggregation of melanosomes in melanophores, thus lightening the skin.


prostaglandin J receptor activity

Combining with prostaglandin J (PGJ(2)), a metabolite of prostaglandin D (PGD(2)) to initiate a change in cell activity.


prostaglandin D receptor activity

Combining with prostaglandin D (PGD(2)) to initiate a change in cell activity.


cellular response to prostaglandin D stimulus

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a prostagladin D stimulus.


negative regulation of type B pancreatic cell apoptotic process

Any process that stops, prevents or reduces the frequency, rate or extent of type B pancreatic cell apoptotic process.


negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway

Any process that stops, prevents or reduces the frequency, rate or extent of an endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway.


positive regulation of type B pancreatic cell apoptotic process

Any process that activates or increases the frequency, rate or extent of type B pancreatic cell apoptotic process.


determination of bilateral symmetry

The establishment of an organism's body plan or part of an organism with respect to a single longitudinal plane. The pattern can either be symmetric, such that the halves are mirror images, or asymmetric where the pattern deviates from this symmetry.


dynein intermediate chain binding

Binding to an intermediate chain of the dynein complex.


dynactin binding

Binding to a dynactin complex; a large protein complex that activates dynein-based motor activity.


positive regulation of pancreatic amylase secretion

Any process that activates or increases the frequency, rate or extent of pancreatic amylase secretion.


calcium-mediated signaling using intracellular calcium source

The series of molecular signals in which a cell uses calcium ions released from an intracellular store to convert a signal into a response.


spine apparatus membrane

The lipid bilayer surrounding the spine apparatus.


postsynaptic recycling endosome membrane

The lipid bilayer surrounding a postsynaptic recycling endosome.


extrinsic component of postsynaptic density membrane

The component of the postsynaptic density membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region.


extrinsic component of postsynaptic early endosome membrane

The component of the postsynaptic early endosome membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region.


postsynaptic Golgi apparatus

The network of the Golgi apparatus structures located within the postsynapse.


postsynaptic endocytic zone membrane

The region of the postsynaptic membrane that is part of the postsynaptic endocytic zone. This region of membrane is associated with stable clathrin puncta.


postsynaptic septin cytoskeleton

The portion of the septin cytoskeleton contained within the postsynapse.


modification of postsynaptic actin cytoskeleton

Any process that modifies the structure of a postsynaptic actin cytoskeleton.


trans-synaptic signaling by trans-synaptic complex, modulating synaptic transmission

Cell-cell signaling between presynapse and postsynapse, mediated by transynaptic protein complexes, that modulates the synaptic transmission properties of the synapse.


regulation of modification of postsynaptic structure

Any process that modulates the frequency, rate or extent of modification of postsynaptic structure.


postsynaptic dense core vesicle exocytosis

The secretion of molecules (e.g. neuropeptides, insulin-related peptides or neuromodulators such as serotonin and dopamine) contained within a postsynaptic dense core vesicle by fusion of the granule with the plasma membrane of the postsynapse in response to increased cytosolic calcium levels.


regulation of recycling endosome localization within postsynapse

Any process that modulates the frequency, rate or extent of transport or maintenance of location of a postsynaptic recycling endosome within the postsynapse.


regulation of neurotransmitter receptor transport, endosome to postsynaptic membrane

Any process that modulates the frequency, rate or extent of the directed movement of neurotransmitter receptor from the postsynaptic endosome to the postsynaptic membrane in transport vesicles.


maintenance of postsynaptic specialization structure

A process which maintains the organization and the arrangement of proteins in the presynaptic specialization.


modification of synaptic structure

Any process that modifies the structure/morphology of a synapse.