hepaticobiliary system development

The progression of the hepaticobiliary system over time, from its formation to the mature structure. The hepaticobiliary system is responsible for metabolic and catabolic processing of small molecules absorbed from the blood or gut, hormones and serum proteins, detoxification, storage of glycogen, triglycerides, metals and lipid soluble vitamins and excretion of bile. Included are the synthesis of albumin, blood coagulation factors, complement, and specific binding proteins.


swim bladder development

biolink:BiologicalProcess biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:NamedThing biolink:Occurrent biolink:OntologyClass biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

The process whose specific outcome is the progression of the swim bladder over time, from its formation to the mature structure. The swim bladder is used by some fishes to maintain buoyancy and may function in addition as a sound producing organ, a sound receptor, and a respiratory organ.


hepatocyte proliferation

The multiplication or reproduction of hepatocytes, resulting in the expansion of a cell population. Hepatocytes form the main structural component of the liver. They are specialized epithelial cells that are organized into interconnected plates called lobules.


gallbladder development

The progression of the gallbladder over time, from its initial formation to the mature structure. The gallbladder is a cavitated organ that stores bile.


hepatic duct development

The progression of the hepatic duct over time, from its formation to the mature structure. The hepatic duct is the duct that leads from the liver to the common bile duct.


liver morphogenesis

The process in which the anatomical structures of the liver are generated and organized.


endodermal digestive tract morphogenesis

The process in which the anatomical structures of the endodermal digestive tract are generated and organized. The endodermal digestive tract includes those portions of the digestive tract that are derived from endoderm.


positive regulation of Wnt signaling pathway

Any process that activates or increases the frequency, rate or extent of Wnt signal transduction.


embryonic retina morphogenesis in camera-type eye

The process in which the anatomical structure of the retina is generated and organized in a camera-type eye during the embryonic life stage.


positive regulation of Wnt signaling pathway, planar cell polarity pathway

Any process that activates or increases the frequency, rate or extent of Wnt signaling pathway, planar cell polarity pathway.


apoptotic body

biolink:CellularComponent biolink:AnatomicalEntity biolink:OrganismalEntity biolink:BiologicalEntity biolink:NamedThing biolink:PhysicalEssence biolink:SubjectOfInvestigation biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

A vesicle containing parts of a dying cell. Apoptotic bodies can be formed during the execution phase of the apoptotic process, when the cell's cytoskeleton breaks up and causes the membrane to bulge outward. These bulges may separate from the cell, taking a portion of cytoplasm with them, to become apoptotic bodies. These are then engulfed by phagocytic cells, and their components recycled. Apoptotic bodies may range in size from 0.8 to 5um.


neural plate pattern specification

The developmental process that results in the creation of defined areas or spaces within the neural plate to which cells respond and eventually are instructed to differentiate.


spinal cord anterior/posterior patterning

The process that regulates the coordinated growth and differentiation that establishes the non-random anterior-posterior spatial arrangement of the spinal cord.


mesodermal cell fate commitment

The cell differentiation process that results in commitment of a cell to become part of the mesoderm.


brain segmentation

Division of the brain into a series of semi-repetitive parts or segments.


regulation of anterior head development

Any process that modulates the frequency, rate or extent of anterior head development.


cell proliferation involved in pronephros development

The multiplication or reproduction of cells, resulting in the expansion of the population in the pronephros.


AXIN1_HUMAN Axin-1 (sprot)

An Axin-1 that is encoded in the genome of human.


AXIN2_HUMAN Axin-2 (sprot)

An Axin-2 that is encoded in the genome of human.


basement membrane assembly

The aggregation, arrangement and bonding together of a set of components to form a basement membrane, a part of the extracellular region that consists of a thin layer of dense material found in various animal tissues interposed between the cells and the adjacent connective tissue.


basal regeneration epithelium of regenerating fin/limb

biolink:AnatomicalEntity biolink:OrganismalEntity biolink:BiologicalEntity biolink:NamedThing biolink:PhysicalEssence biolink:SubjectOfInvestigation biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

Layer of the wound epidermis that surrounds the blastema in the fin or limb[ZFA,modified].


cyclin-dependent protein kinase holoenzyme complex

Cyclin-dependent protein kinases (CDKs) are enzyme complexes that contain a kinase catalytic subunit associated with a regulatory cyclin partner.


re-entry into mitotic cell cycle

The resumption of the mitotic cell division cycle by cells that were in a quiescent or other non-dividing state.


mammary gland alveolus development

The progression of the mammary gland alveolus over time, from its formation to its mature state. The mammary gland alveolus is a sac-like structure that is found in the mature gland.


lactation

The regulated release of milk from the mammary glands and the period of time that a mother lactates to feed her young.


regulation of G1/S transition of mitotic cell cycle

Any signaling pathway that modulates the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G1 phase to S phase of the mitotic cell cycle.


positive regulation of mammary gland epithelial cell proliferation

Any process that activates or increases the rate or extent of mammary gland epithelial cell proliferation.


SUMO ligase complex

A protein ligase complex that enables protein sumoylation. Consists of a SUMO-protein transferase and other proteins that may confer substrate specificity of the complex.


WW domain binding

biolink:MolecularActivity biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:NamedThing biolink:Occurrent biolink:OntologyClass biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

Binding to a WW domain of a protein, a small module composed of 40 amino acids and plays a role in mediating protein-protein interactions via proline-rich regions.


cellular response to organic cyclic compound

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic cyclic compound stimulus.


placenta development

The process whose specific outcome is the progression of the placenta over time, from its formation to the mature structure. The placenta is an organ of metabolic interchange between fetus and mother, partly of embryonic origin and partly of maternal origin.


cold-induced thermogenesis

The process by which heat is generated by increasing metabolism in response to cold ambient temperatures in order to maintain a stable core body temperature.


diet induced thermogenesis

The process that results in increased metabolic rate in tissues of an organism. It is triggered by the detection of dietary excess. This process is achieved via signaling in the sympathetic nervous system.


mucus layer

An extracellular region part that consists of a protective layer of mucus secreted by epithelial cells lining tubular organs of the body such as the colon or secreted into fluids such as saliva. Mucus is a viscous slimy secretion consisting of mucins (i.e. highly glycosylated mucin proteins) and various inorganic salts dissolved in water, with suspended epithelial cells and leukocytes.


extracellular matrix structural constituent

The action of a molecule that contributes to the structural integrity of the extracellular matrix.


axonal growth cone

The migrating motile tip of a growing nerve cell axon.


microtubule plus-end binding

Binding to the plus end of a microtubule.


cytoplasmic microtubule organization

A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of structures formed of microtubules and associated proteins in the cytoplasm of a cell.


muscle cell cellular homeostasis

The cellular homeostatic process that preserves a muscle cell in a stable functional or structural state.


regulation of epithelial cell differentiation

Any process that modulates the frequency, rate or extent of epithelial cell differentiation.


negative regulation of epithelial cell proliferation involved in prostate gland development

Any process that decreases the rate, frequency or extent of epithelial cell proliferation that contributes to the progression of the prostate gland over time.


positive regulation of microtubule polymerization

Any process that activates or increases the frequency, rate or extent of microtubule polymerization.


proximal/distal pattern formation

The regionalization process in which specific areas of cell differentiation are determined along a proximal/distal axis. The proximal/distal axis is defined by a line that runs from main body (proximal end) of an organism outward (distal end).


positive regulation of cell division

Any process that activates or increases the frequency, rate or extent of cell division.


negative regulation of odontogenesis

Any process that stops, prevents, or reduces the frequency, rate or extent of the formation and development of a tooth or teeth.


positive regulation of pseudopodium assembly

Any process that activates or increases the frequency, rate or extent of the assembly of pseudopodia.


regulation of nitrogen compound metabolic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving nitrogen or nitrogenous compounds.


regulation of attachment of spindle microtubules to kinetochore

Any process that modulates the frequency, rate or extent of the attachment of spindle microtubules to the kinetochore.


microvillus membrane

The portion of the plasma membrane surrounding a microvillus.


morula cell

biolink:Cell biolink:AnatomicalEntity biolink:OrganismalEntity biolink:BiologicalEntity biolink:NamedThing biolink:PhysicalEssence biolink:SubjectOfInvestigation biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

A cell of the early embryo at the developmental stage in which the blastomeres, resulting from repeated mitotic divisions of the fertilized ovum (zygote), form a compact cell mass.


cadherin binding

Binding to cadherin, a type I membrane protein involved in cell adhesion.


alpha-catenin binding

Binding to catenin complex alpha subunit.


central nervous system vasculogenesis

The differentiation of endothelial cells from progenitor cells during blood vessel development, and the de novo formation of blood vessels and tubes in the central nervous system. The capillary endothelial cells in the brain are specialized to form the blood-brain barrier.


limb development

The process whose specific outcome is the progression of a limb over time, from its formation to the mature structure. A limb is an appendage of an animal used for locomotion or grasping. Examples include legs, arms or some types of fin.


embryonic axis specification

The establishment, maintenance and elaboration of a pattern along a line or a point in an embryo.


layer formation in cerebral cortex

The detachment of cells from radial glial fibers at the appropriate time when they cease to migrate and form distinct layer in the cerebral cortex.


establishment of blood-brain barrier

Establishment of the barrier between the blood and the brain. The cells in the brain are packed tightly together preventing the passage of most molecules from the blood into the brain. Only lipid soluble molecules or those that are actively transported can pass through the blood-brain barrier.


positive regulation of epithelial to mesenchymal transition

Any process that increases the rate, frequency, or extent of epithelial to mesenchymal transition. Epithelial to mesenchymal transition is where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell.


genitalia morphogenesis

The process in which the anatomical structures of genitalia are generated and organized. The genitalia are the organs of reproduction or generation, external and internal.


establishment of blood-retinal barrier

Establishment of the barrier between the blood and the retina. The blood-retinal barrier is located at two levels, forming an outer barrier in the retinal pigment epithelium and an inner barrier in the endothelial membrane of the retinal vessels. Both these membranes have tight junctions of the 'nonleaky' type.


lens morphogenesis in camera-type eye

The process in which the anatomical structures of the lens are generated and organized. The lens is a transparent structure in the eye through which light is focused onto the retina. An example of this process is found in Mus musculus.


endodermal cell fate commitment

The cell differentiation process that results in commitment of a cell to become part of the endoderm.


mesenchymal cell proliferation

The multiplication or reproduction of cells, resulting in the expansion of a mesenchymal cell population. A mesenchymal cell is a cell that normally gives rise to other cells that are organized as three-dimensional masses, rather than sheets.


positive regulation of neuroblast proliferation

Any process that activates or increases the rate of neuroblast proliferation.


embryonic forelimb morphogenesis

The process, occurring in the embryo, by which the anatomical structures of the forelimb are generated and organized. The forelimbs are the front limbs of an animal, e.g. the arms of a human.


animal organ development

Development of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions.


embryonic hindlimb morphogenesis

The process, occurring in the embryo, by which the anatomical structures of the hindlimbs are generated and organized. The hindlimbs are the posterior limbs of an animal.


lung-associated mesenchyme development

The biological process whose specific outcome is the progression of a lung-associated mesenchyme from an initial condition to its mature state. This process begins with the formation of lung-associated mesenchyme and ends with the mature structure. Lung-associated mesenchyme is the tissue made up of loosely connected mesenchymal cells in the lung.


negative regulation of oligodendrocyte differentiation

Any process that stops, prevents, or reduces the frequency, rate or extent of oligodendrocyte differentiation.


metanephros morphogenesis

The process in which the anatomical structures of the metanephros are generated and organized.


hair follicle placode formation

The developmental process in which a hair placode forms. An hair follicle placode is a thickening of the ectoderm that will give rise to the hair follicle bud.


male genitalia development

The process whose specific outcome is the progression of the male genitalia over time, from its formation to the mature structure.


lung induction

The close range interaction of two or more cells or tissues that causes the cells of the foregut to change their fates and specify the development of the lung.


renal inner medulla development

The process whose specific outcome is the progression of the renal inner medulla over time, from its formation to the mature structure. The renal inner medulla is unique to mammalian kidneys and is the innermost region of the mammalian kidney.


trachea formation

The process pertaining to the initial formation of a trachea from unspecified parts. The process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the trachea is recognizable. The trachea is the portion of the airway that attaches to the bronchi as it branches.


positive regulation of determination of dorsal identity

Any process that activates or increases the frequency, rate or extent of determination of dorsal identity.


negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis

Any process that decreases the rate, frequency or extent of the transition where a mesenchymal cell establishes apical/basolateral polarity,forms intercellular adhesive junctions, synthesizes basement membrane components and becomes an epithelial cell that will contribute to the shaping of the metanephros.


regulation of T cell proliferation

Any process that modulates the frequency, rate or extent of T cell proliferation.


mesenchymal cell proliferation involved in lung development

The multiplication or reproduction of cells, resulting in the expansion of a mesenchymal cell population that contributes to the progression of the lung over time. A mesenchymal cell is a cell that normally gives rise to other cells that are organized as three-dimensional masses, rather than sheets.


positive regulation of epithelial cell proliferation involved in prostate gland development

Any process that increases the rate, frequency or extent of epithelial cell proliferation that contributes to the progression of the prostate gland over time.


fungiform papilla formation

The developmental process pertaining to the initial formation of a spongiform papilla from unspecified parts. The fungiform papilla is a mushroom-shaped papilla of the tongue.


renal outer medulla development

The process whose specific outcome is the progression of the renal outer medulla over time, from its formation to the mature structure. The renal outer medulla is the region of the kidney that lies between the renal cortex and the renal inner medulla.


nephron tubule formation

The developmental process pertaining to the initial formation of a nephron tubule from unspecified parts. A nephron tubule is an epithelial tube that is part of the nephron, the functional part of the kidney.


oviduct development

The reproductive developmental process whose specific outcome is the progression of an oviduct over time, from its formation to the mature structure. An oviduct is a tube through which an ova passes from the ovary to the uterus, or from the ovary to the outside of the organism.


renal vesicle formation

The developmental process pertaining to the initial formation of the renal vesicle from condensed mesenchymal cells. The renal vesicle is the primordial structure of the nephron epithelium, and is formed by the condensation of mesenchymal cells.


lung cell differentiation

The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features of a mature cell found in the lung. Differentiation includes the processes involved in commitment of a cell to a specific fate.


positive regulation of endothelial cell differentiation

Any process that activates or increases the frequency, rate or extent of endothelial cell differentiation.


trachea morphogenesis

The process in which a trachea is generated and organized. The trachea is the portion of the airway that attaches to the bronchi as it branches.


positive regulation of branching involved in lung morphogenesis

Any process that increases the rate, frequency, or extent of the process in which a highly ordered sequence of patterning events generates the branched structures of the lung, consisting of reiterated combinations of bud outgrowth, elongation, and dichotomous subdivision of terminal units.


PROP1_MOUSE Homeobox protein prophet of Pit-1 (sprot)

A homeobox protein prophet of Pit-1 that is encoded in the genome of mouse.


proximal straight tubule development

The process whose specific outcome is the progression of the proximal straight tubule over time, from its formation to the mature structure. The proximal straight tubule is the part of the descending limb that extends from the proximal convoluted tubule to the descending thin tubule.


pronephric proximal tubule development

The progression of the pronephric proximal tubule over time, from its formation to the mature structure. A pronephric nephron tubule is an epithelial tube that is part of the pronephros.


diencephalon development

The process whose specific outcome is the progression of the diencephalon over time, from its formation to the mature structure. The diencephalon is the paired caudal parts of the prosencephalon from which the thalamus, hypothalamus, epithalamus and subthalamus are derived; these regions regulate autonomic, visceral and endocrine function, and process information directed to the cerebral cortex.


hypothalamus cell differentiation

The differentiation of cells that will contribute to the structure and function of the hypothalamus.


response to steroid hormone

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a steroid hormone stimulus.


prostaglandin E receptor activity

Combining with prostaglandin E (PGE(2)) to initiate a change in cell activity.


regulation of pronephric nephron tubule development

Any process that modulates the frequency, rate or extent of pronephric nephron tubule development.


pronephric distal tubule development

The process whose specific outcome is the progression of the pronephric distal tubule over time, from its formation to the mature structure. A pronephric nephron tubule is an epithelial tube that is part of the pronephros.


pronephric duct morphogenesis

The process in which the anatomical structures of the pronephric duct are generated and organized. The pronephric duct collects the filtrate from the pronephric tubules and opens to the exterior of the kidney.


regulation of RNA biosynthetic process

Any process that modulates the frequency, rate or extent of RNA biosynthetic process.


centrosome separation

The process in which duplicated centrosome components move away from each other. The centriole pair within each centrosome becomes part of a separate microtubule organizing center that nucleates a radial array of microtubules called an aster. The two asters move to opposite sides of the nucleus to form the two poles of the mitotic spindle.


BORG1_MOUSE Cdc42 effector protein 2 (sprot)

A Cdc42 effector protein 2 that is encoded in the genome of mouse.


S12A3_MOUSE Solute carrier family 12 member 3 (sprot)

A solute carrier family 12 member 3 that is encoded in the genome of mouse.


RP1_MOUSE Oxygen-regulated protein 1 (sprot)

An oxygen-regulated protein 1 that is encoded in the genome of mouse.


RL13A_HUMAN Large ribosomal subunit protein uL13 (sprot)

A 60S ribosomal protein L13a that is encoded in the genome of human.


STE20-related kinase adapter protein beta isoform 1 (mouse)

A STE20-related kinase adapter protein beta isoform 1 that is encoded in the genome of mouse.


sporulation resulting in formation of a cellular spore

The process in which a relatively unspecialized cell acquires the specialized features of a cellular spore, a cell form that can be used for dissemination, for survival of adverse conditions because of its heat and dessication resistance, and/or for reproduction.


ascospore-type prospore membrane formation

The process in which the nascent membrane forms at the meiotic outer plaque and grows until closure occurs and forespores, or prospores, are formed.


RRAS_HUMAN Ras-related protein R-Ras (sprot)

A Ras-related protein R-Ras that is encoded in the genome of human.


ARFG2_HUMAN ADP-ribosylation factor GTPase-activating protein 2 (sprot)

An ADP-ribosylation factor GTPase-activating protein 2 that is encoded in the genome of human.


ARFG3_HUMAN ADP-ribosylation factor GTPase-activating protein 3 (sprot)

An ADP-ribosylation factor GTPase-activating protein 3 that is encoded in the genome of human.


RB3GP_HUMAN Rab3 GTPase-activating protein catalytic subunit (sprot)

A Rab3 GTPase-activating protein catalytic subunit that is encoded in the genome of human.


GRP3_HUMAN Ras guanyl-releasing protein 3 (sprot)

A Ras guanyl-releasing protein 3 that is encoded in the genome of human.


pro-T cell differentiation

The process in which a precursor cell type acquires the specialized features of a pro-T cell. Pro-T cells are the earliest stage of the T cell lineage but are not fully committed.


bulbus arteriosus development

The process whose specific outcome is the progression of the bulbus arteriosus over time, from its formation to the mature structure. The bulbus arteriosus is an elastic heart chamber.


swimming behavior

The response to external or internal stimuli that results in the locomotory process of swimming. Swimming is the self-propelled movement of an organism through the water.


optomotor response

Eye, head or whole body movements that help to compensate movements of the environment in order to stabilize its image on the retina. In the case of whole body movements, these motor actions may also stabilize a locomotor course in response to some disturbance. Examples include: the optokinetic reflex, which allows human eyes to follow objects in motion while the head remains stationary reflex; the optomotor responses of flying insects and swimming fish.


amyloid-beta formation

The generation of amyloid-beta by cleavage of the amyloid precursor protein (APP).


regulation of endopeptidase activity

Any process that modulates the frequency, rate or extent of endopeptidase activity, the endohydrolysis of peptide bonds within proteins.


regulation of protein localization

Any process that modulates the frequency, rate or extent of any process in which a protein is transported to, or maintained in, a specific location.


myotome development

The progression of the myotome over time, from its formation to the mature structure. The myotome is the portion of the somite that will give rise to muscle.


T-tubule

Invagination of the plasma membrane of a muscle cell that extends inward from the cell surface around each myofibril. The ends of T-tubules make contact with the sarcoplasmic reticulum membrane.


stress fiber

A contractile actin filament bundle that consists of short actin filaments with alternating polarity, cross-linked by alpha-actinin and possibly other actin bundling proteins, and with myosin present in a periodic distribution along the fiber.


mitochondrial translation

The chemical reactions and pathways resulting in the formation of a protein in a mitochondrion. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein; the mitochondrion has its own ribosomes and transfer RNAs, and uses a genetic code that differs from the nuclear code.


voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization

Enables the transmembrane transfer of a potassium ion by a voltage-gated channel through the plasma membrane of a cardiac muscle cell contributing to the repolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded.


voltage-gated sodium channel activity involved in cardiac muscle cell action potential

Enables the transmembrane transfer of a sodium ion by a voltage-gated channel through the plasma membrane of a cardiac muscle cell contributing to the depolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded.


T-tubule organization

A process that is carried out at the cellular level that results in the assembly, arrangement of constituent parts, or disassembly of the T-tubule. A T-tubule is an invagination of the plasma membrane of a muscle cell that extends inward from the cell surface around each myofibril.


calcium ion import across plasma membrane

The directed movement of calcium ions from outside of a cell, across the plasma membrane and into the cytosol.


cell communication involved in cardiac conduction

Any process that mediates interactions between a cell and its surroundings that contributes to the process of cardiac conduction. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment.


voltage-gated calcium channel activity involved in cardiac muscle cell action potential

Enables the transmembrane transfer of a calcium ion by a voltage-gated channel across the plasma membrane of a cardiac muscle cell that contributes to the depolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded.


negative regulation of glucose import

Any process that stops, prevents, or reduces the frequency, rate or extent of the import of the hexose monosaccharide glucose into a cell or organelle.


release of sequestered calcium ion into cytosol by sarcoplasmic reticulum

The process in which the release of sequestered calcium ion by sarcoplasmic reticulum into cytosol occurs via calcium release channels.


cellular response to caffeine

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a caffeine stimulus. Caffeine is an alkaloid found in numerous plant species, where it acts as a natural pesticide that paralyzes and kills certain insects feeding upon them.


ventricular cardiac muscle cell membrane repolarization

The process in which ions are transported across the plasma membrane of a ventricular cardiac muscle cell such that the membrane potential changes in the repolarizing direction, toward the steady state potential. For example, the repolarization during an action potential is from a positive membrane potential towards a negative resting potential.


protein-DNA complex assembly

The aggregation, arrangement and bonding together of proteins and DNA molecules to form a protein-DNA complex.


ventricular cardiac muscle cell action potential

An action potential that occurs in a ventricular cardiac muscle cell.


cellular component maintenance

The organization process that preserves a cellular component in a stable functional or structural state.


mitochondrial RNA catabolic process

The chemical reactions and pathways resulting in the breakdown of RNA transcribed from the mitochondrial genome and occurring in the mitochondrion.


cardiac muscle cell action potential involved in contraction

An action potential that occurs in a cardiac muscle cell and is involved in its contraction.


potassium ion export across plasma membrane

The directed movement of potassium ions from inside of a cell, across the plasma membrane and into the extracellular region.


atrial cardiac muscle cell action potential

An action potential that occurs in an atrial cardiac muscle cell.


negative regulation of glucose catabolic process to lactate via pyruvate

Any process that stops, prevents or reduces the frequency, rate or extent of glucose catabolic process to lactate via pyruvate.


fructose 2,6-bisphosphate metabolic process

The chemical reactions and pathways involving fructose 2,6-bisphosphate. The D enantiomer is an important regulator of the glycolytic and gluconeogenic pathways. It inhibits fructose 1,6-bisphosphatase and activates phosphofructokinase.


glucose catabolic process to lactate via pyruvate

The anaerobic enzymatic chemical reactions and pathways resulting in the breakdown of glucose to lactate, via canonical glycolysis, yielding energy in the form of adenosine triphosphate (ATP).


potassium channel regulator activity

Binds to and modulates the activity of a potassium channel.


sodium ion import across plasma membrane

The directed movement of sodium ions from outside of a cell, across the plasma membrane and into the cytosol.


ventricular cardiac muscle cell development

The process whose specific outcome is the progression of a ventricular cardiac muscle cell over time, from its formation to the mature state. Cardiac muscle cells are striated muscle cells that are responsible for heart contraction. The ventricle is the part of the heart that pumps blood out of the organ.


Purkinje myocyte differentiation

The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of a Purkinje myocyte (also known as cardiac Purkinje fiber cell). These cells are specialized cardiomyocytes that receive signals from the bundle of His and innervate the ventricular cardiac muscle.


troponin complex

A complex of accessory proteins (typically troponin T, troponin I and troponin C) found associated with actin in muscle thin filaments; involved in calcium regulation of muscle contraction.


ATP-binding cassette sub-family C member 9 isoform 1 (mouse)

An ATP-binding cassette sub-family C member 9 isoform 1 that is encoded in the genome of mouse.


potassium voltage-gated channel subfamily D member 3 isoform 1 (mouse)

A voltage-gated potassium channel KCND3 isoform 1 that is encoded in the genome of mouse.


sodium channel protein type 5 subunit alpha isoform 1 (mouse)

A sodium channel protein type 5 subunit alpha (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9JJV9-1.


positive regulation of heart contraction

Any process that activates or increases the frequency, rate or extent of heart contraction.


regulation of convergent extension involved in gastrulation

Any process that modulates the frequency, rate or extent of convergent extension involved in gastrulation.


lens fiber cell morphogenesis

The process in which the structures of a lens fiber cell are generated and organized. This process occurs while the initially relatively unspecialized cell is acquiring the specialized features of a lens fiber cell. A lens fiber cell is any of the elongated, tightly packed cells that make up the bulk of the mature lens in a camera-type eye.


The process in which the anatomical structure of the midbrain-hindbrain boundary is generated and organized. The midbrain-hindbrain domain of the embryonic brain is comprised of the mesencephalic vesicle and the first rhombencephalic vesicle at early somitogenesis stages. An organizing center at the boundary patterns the midbrain and hindbrain primordia of the neural plate.


protein localization to cell junction

A process in which a protein is transported to, or maintained in, a location within a cell junction.


regulation of cell-substrate junction organization

Any process that modulates the frequency, rate or extent of cell-substrate junction organization.


negative regulation of establishment of protein localization

Any process that stops, prevents or reduces the frequency, rate or extent of establishment of protein localization.


positive regulation of establishment of protein localization

Any process that activates or increases the frequency, rate or extent of establishment of protein localization.


membrane repolarization during cardiac muscle cell action potential

The process in which ions are transported across a membrane such that the cardiac muscle cell plasma membrane potential changes in the direction from the positive membrane potential at the peak of the action potential towards the negative resting potential.


phospholipase binding

Binding to a phospholipase.


negative regulation of protein localization

Any process that stops, prevents or reduces the frequency, rate or extent of a protein localization.


perisynaptic space

The extracellular region immediately adjacent to to a synapse.


protein-containing complex organization

Any process in which macromolecules aggregate, disaggregate, or are modified, resulting in the formation, disassembly, or alteration of a protein complex.


rod bipolar cell (sensu Mus)

A bipolar neuron found in the retina that is synapsed by rod photoreceptor cells.  These neurons have axons that arborize and synapse to targets in inner plexiform layers 4 and 5 and depolarize in response to light.


TPBG_MOUSE Trophoblast glycoprotein (sprot)

A trophoblast glycoprotein that is encoded in the genome of mouse.


CP110_MOUSE Centriolar coiled-coil protein of 110 kDa (sprot)

A centriolar coiled-coil protein of 110 kDa that is encoded in the genome of mouse.


CANB2_MOUSE Calcineurin subunit B type 2 (sprot)

A calcineurin subunit B type 2 that is encoded in the genome of mouse.


E9Q8Q6_MOUSE Coiled-coil domain containing 141 (trembl)


cellular response to glucocorticoid stimulus

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucocorticoid stimulus. Glucocorticoids are hormonal C21 corticosteroids synthesized from cholesterol with the ability to bind with the cortisol receptor and trigger similar effects. Glucocorticoids act primarily on carbohydrate and protein metabolism, and have anti-inflammatory effects.


ADA complex

A chromatin remodeling complex that regulates transcription via acetylation primarily of nucleosomal histones H3 and H2B. In budding yeast shares the histone acetylation (HAT) module of ADA2-GCN5-NGG1-SGF29 with the related SAGA complex.


regulation of JNK cascade

Any process that modulates the frequency, rate or extent of signal transduction mediated by the JNK cascade.


olfactory placode formation

The formation of a thickening of the neural ectoderm in the head region of the vertebrate embryo which develops into the olfactory region of the nasal cavity.


forebrain anterior/posterior pattern specification

The creation of specific areas of progenitor domains along the anterior-posterior axis of the developing forebrain.


embryonic eye morphogenesis

The process occurring in the embryo by which the anatomical structures of the post-embryonic eye are generated and organized.


lens placode formation

The initial developmental process that will lead to the formation of an eye.


WNT3A_HUMAN Protein Wnt-3a (sprot)

A protein Wnt-3a that is encoded in the genome of human.


WNT5A_HUMAN Protein Wnt-5a (sprot)

A protein Wnt-5a that is encoded in the genome of human.


WIF1_HUMAN Wnt inhibitory factor 1 (sprot)

A Wnt inhibitory factor 1 that is encoded in the genome of human.


SOST_HUMAN Sclerostin (sprot)

A sclerostin that is encoded in the genome of human.


DACT1_HUMAN Dapper homolog 1 (sprot)

A dapper homolog 1 that is encoded in the genome of human.


WNT9A_HUMAN Protein Wnt-9a (sprot)

A protein Wnt-9a that is encoded in the genome of human.


LRP5_HUMAN Low-density lipoprotein receptor-related protein 5 (sprot)

A low-density lipoprotein receptor-related protein 5 that is encoded in the genome of human.


LRP6_HUMAN Low-density lipoprotein receptor-related protein 6 (sprot)

A low-density lipoprotein receptor-related protein 6 that is encoded in the genome of human.


DKK1_HUMAN Dickkopf-related protein 1 (sprot)

A dickkopf-related protein 1 that is encoded in the genome of human.


WNT4_HUMAN Protein Wnt-4 (sprot)

A protein Wnt-4 that is encoded in the genome of human.


SFRP1_HUMAN Secreted frizzled-related protein 1 (sprot)

A secreted frizzled-related protein 1 that is encoded in the genome of human.


KREM2_HUMAN Kremen protein 2 (sprot)

A Kremen protein 2 that is encoded in the genome of human.


SFRP2_HUMAN Secreted frizzled-related protein 2 (sprot)

A secreted frizzled-related protein 2 that is encoded in the genome of human.


KREM1_HUMAN Kremen protein 1 (sprot)

A Kremen protein 1 that is encoded in the genome of human.


DKK4_HUMAN Dickkopf-related protein 4 (sprot)

A dickkopf-related protein 4 that is encoded in the genome of human.


DKK2_HUMAN Dickkopf-related protein 2 (sprot)

A dickkopf-related protein 2 that is encoded in the genome of human.


posterior lateral line neuromast primordium migration

The migration of a relatively undifferentiated cell along the developing posterior lateral line, originating from cranial ectodermal placodes situated behind the ear. The neuromast primordium deposits proneuromasts along the lateral line, from which the neuromasts will develop.


heart valve development

The progression of a heart valve over time, from its formation to the mature structure. A heart valve is a structure that restricts the flow of blood to different regions of the heart and forms from an endocardial cushion.


spindle organization

A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the spindle, the array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during DNA segregation and serves to move the duplicated chromosomes apart.


regulation of retinoic acid biosynthetic process

Any process that modulates the frequency, rate or extent of retinoic acid biosynthetic process.


zona limitans intrathalamica formation

The formation of the narrow stripe of cells that lies between the prospective dorsal and ventral thalami. This boundary contains signals that pattern the prethalamic and thalamic territories of the future mid-diencephalon.


superior colliculus development

The process whose specific outcome is the progression of the superior colliculus over time, from its formation to the mature structure. The superior colliculus is also known as the optic tectum or simply tectum and is a paired structure that forms a major component of the vertebrate midbrain.


cell morphogenesis involved in conjugation with cellular fusion

The change in form (cell shape and size) that occurs during sexual reproduction in order to facilitate direct contact between the compatible mating types in organisms that undergo conjugation cellular fusion.


myosin V binding

Binding to a class V myosin; myosin V is a dimeric molecule involved in intracellular transport.


site of polarized growth

Any part of a cell where non-isotropic growth takes place.


mating projection tip

The apex of the mating projection in unicellular fungi exposed to mating pheromone; site of polarized growth.


regulation of retinoic acid receptor signaling pathway

Any process that modulates the frequency, rate or extent of retinoic acid receptor signaling pathway activity.


rostrocaudal neural tube patterning

The process in which the neural tube is divided into specific regions along the rostrocaudal axis.


endothelial cell fate specification

The process involved in the specification of identity of an endothelial cell. Once specification has taken place, a cell will be committed to differentiate down a specific pathway if left in its normal environment.


cell proliferation in dorsal spinal cord

The multiplication or reproduction of cells, resulting in the expansion of the dorsal spinal cord cell population.


cell proliferation in midbrain

The multiplication or reproduction of cells, resulting in the expansion of a cell population in the midbrain.


CADH2_CHICK Cadherin-2 (sprot)

A cadherin-2 that is encoded in the genome of chicken.


posterior lateral line development

The process whose specific outcome is the progression of the posterior lateral line over time, from its formation to the mature structure. The posterior lateral line consists of small sensory patches (neuromasts) located superficially on the skin or just under the skin in fluid-filled canals on the body and trunk of all fishes and most amphibians. The posterior lateral line develops from cranial ectodermal placodes situated behind the ear.


fin development

The process whose specific outcome is the progression of a fin over time, from its formation to the mature structure.


positive regulation of neurogenesis

Any process that activates or increases the frequency, rate or extent of neurogenesis, the generation of cells within the nervous system.


posterior lateral line neuromast deposition

The process in which a migrating neuromast primordium deposits clusters of undifferentiated cells (proneuromasts) along its migratory path in the developing posterior lateral line.


posterior lateral line neuromast development

The process whose specific outcome is the progression of the posterior lateral line neuromast over time, from its formation to the mature structure. The neuromast is the sensory receptor of the anterior lateral line system and is composed of a population of sensory hair cells, and nonsensory supporting cells and mantle cells. Neuromast are located superficially on the epithelium or in lateral line canals.


regulation of cell proliferation involved in tissue homeostasis

Any process that modulates the frequency, rate or extent of cell proliferation resulting in the maintenance of a steady-state number of cells within a tissue.


caudal fin development

The process whose specific outcome is the progression of the caudal fin over time, from its formation to the mature structure.


embryonic camera-type eye morphogenesis

The process in which the anatomical structures of the eye are generated and organized during embryonic development.


embryonic camera-type eye formation

The developmental process pertaining to the initial formation of a camera-type eye from unspecified neurectoderm. This process begins with the differentiation of cells that form the optic field and ends when the optic cup has attained its shape.


GDP phosphatase activity

Catalysis of the reaction: GDP + H2O = GMP + phosphate.


carbohydrate binding

Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates.


nucleic acid binding

Binding to a nucleic acid.


unfolded protein binding

Binding to an unfolded protein.


ER retention sequence binding

Binding to an endoplasmic reticulum (ER) retention sequence, a specific peptide sequence that ensures a protein is retained within the ER.


soluble NSF attachment protein activity

Binding to both N-ethylmaleimide-sensitive fusion protein (NSF) and a cis-SNARE complex (i.e. a SNARE complex in which all proteins are associated with the same membrane) and increasing the ATPase activity of NSF, thereby allowing ATP hydrolysis by NSF to disassemble the cis-SNARE complex.


Catalysis of the reaction: UDP-N-acetyl-D-glucosamine = UDP-N-acetyl-D-galactosamine.


nucleotide binding

Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose.


ATP-dependent peptidase activity

Catalysis of the hydrolysis of peptide bonds, driven by ATP hydrolysis.


UDP-galactose transmembrane transporter activity

Enables the transfer of a UDP-galactose from one side of a membrane to the other. UDP-galactose is a substance composed of galactose in glycosidic linkage with uridine diphosphate.


oligopeptide transmembrane transporter activity

Enables the transfer of oligopeptides from one side of a membrane to the other. Oligopeptides are molecules that contain a small number (2 to 20) of amino-acid residues connected by peptide linkages.


oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor

Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces disulfide.


glycolipid binding

Binding to a glycolipid, any compound containing one or more monosaccharide residues bound by a glycosidic linkage to a hydrophobic group such as an acylglycerol, a sphingoid, a ceramide (N-acylsphingoid) or a prenyl phosphate.


structural constituent of cuticle

The action of a molecule that contributes to the structural integrity of a cuticle.


syntaxin-1 binding

Binding to a syntaxin-1 SNAP receptor.


PDIA6_HUMAN Protein disulfide-isomerase A6 (sprot)

A protein disulfide-isomerase A6 that is encoded in the genome of human.


ERN1_HUMAN Serine/threonine-protein kinase/endoribonuclease IRE1 (sprot)

A serine/threonine-protein kinase/endoribonuclease IRE1 that is encoded in the genome of human.


negative regulation of IRE1-mediated unfolded protein response

Any process that stops, prevents or reduces the frequency, rate or extent of the IRE1-mediated unfolded protein response.


IL23A_HUMAN Interleukin-23 subunit alpha (sprot)

An interleukin-23 subunit alpha that is encoded in the genome of human.


ribosomal large subunit export from nucleus

The directed movement of a ribosomal large subunit from the nucleus into the cytoplasm.


regulation of chaperone-mediated protein folding

Any process that modulates the frequency, rate or extent of chaperone-mediated protein folding.


MHC class I peptide loading complex

A large, multisubunit complex which consists of the MHC class I-beta 2 microglobulin dimer, the transporter associated with antigen presentation (TAP), tapasin (an MHC-encoded membrane protein), the chaperone calreticulin and the thiol oxidoreductase ERp57. Functions in the assembly of peptides with newly synthesized MHC class I molecules.


epithelial cell maturation involved in salivary gland development

The developmental process, independent of morphogenetic (shape) change, that is required for an epithelial cell of the salivary gland to attain its fully functional state.


ER overload response

biolink:Pathway biolink:BiologicalProcess biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:NamedThing biolink:OntologyClass biolink:Occurrent biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

The series of molecular signals initiated by the accumulation of normal or misfolded proteins in the endoplasmic reticulum and leading to activation of transcription by NF-kappaB.


nuclear-transcribed mRNA catabolic process, no-go decay

The chemical reactions and pathways resulting in the breakdown of the transcript body of a nuclear-transcribed mRNA with stalls in translation elongation.


CCA tRNA nucleotidyltransferase activity

Catalysis of the reaction: a tRNA precursor + ATP + 2 CTP = a tRNA with a 3' CCA end + 3 diphosphate.


RNZ1_HUMAN Zinc phosphodiesterase ELAC protein 1 (sprot)

A zinc phosphodiesterase ELAC protein 1 that is encoded in the genome of human.


RIOK3_HUMAN Serine/threonine-protein kinase RIO3 (sprot)

A serine/threonine-protein kinase RIO3 that is encoded in the genome of human.


BYST_HUMAN Bystin (sprot)

A bystin that is encoded in the genome of human.


RIOK1_HUMAN Serine/threonine-protein kinase RIO1 (sprot)

A serine/threonine-protein kinase RIO1 that is encoded in the genome of human.


RIOK2_HUMAN Serine/threonine-protein kinase RIO2 (sprot)

A serine/threonine-protein kinase RIO2 that is encoded in the genome of human.


LTV1_HUMAN Protein LTV1 homolog (sprot)

A protein LTV1 that is encoded in the genome of human.


PNO1_HUMAN RNA-binding protein PNO1 (sprot)

An RNA-binding protein PNO1 that is encoded in the genome of human.


TSR1_HUMAN Pre-rRNA-processing protein TSR1 homolog (sprot)

A pre-rRNA-processing protein TSR1 that is encoded in the genome of human.


ANKZ1_HUMAN tRNA endonuclease ANKZF1 (sprot)

An ankyrin repeat and zinc finger domain-containing protein 1 that is encoded in the genome of human.


NEMF_HUMAN Ribosome quality control complex subunit NEMF (sprot)

A serologically defined colon cancer antigen 1 that is encoded in the genome of human.


negative regulation of RNA export from nucleus

Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of RNA from the nucleus into the cytoplasm.


peripheral nervous system axon ensheathment

The process in which a Schwann cell membrane closes around an axon in the peripheral nervous system. This can be a myelinating or a non-myelinating neuron-glial interaction.


response to virus

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a virus.


protein homotrimerization

The formation of a protein homotrimer, a macromolecular structure consisting of three noncovalently associated identical subunits.


response to arsenic-containing substance

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an arsenic stimulus from compounds containing arsenic, including arsenates, arsenites, and arsenides.


response to molecule of bacterial origin

Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus by molecules of bacterial origin such as peptides derived from bacterial flagellin.


regulation of hematopoietic progenitor cell differentiation

Any process that modulates the frequency, rate or extent of hematopoietic progenitor cell differentiation.


positive regulation of hematopoietic progenitor cell differentiation

Any process that activates or increases the frequency, rate or extent of hematopoietic progenitor cell differentiation.


positive regulation of type II interferon-mediated signaling pathway

Any process that increases the rate, frequency or extent of an interferon-gamma-mediated signaling pathway.


RIG-I signaling pathway

The series of molecular signals initiated by the binding ssRNA or dsRNA from another organism to the cytoplasmic pattern recognition receptor (PRR) RIG-1 (also known as DDX58). RIG-I detects RNA synthesized during viral replication or shed by non-viral pathogens, and triggers a signaling pathway to protect the host against infection, for example by inducing the expression of cytokines.


lipopolysaccharide immune receptor activity

Combining with a lipopolysaccharide and transmitting the signal across the cell membrane to initiate an innate immune response. Lipopolysaccharides (LPS) are major components of the outer membrane of Gram-negative bacteria, making them prime targets for recognition by the immune system.


nuclear factor NF-kappa-B p105 subunit isoform 2 (human)

A nuclear factor NF-kappa-B p105 subunit isoform 3 that is encoded in the genome of human.


transcription factor NF-kappa-B subunit

A protein that has a core domain composition consisting of a Rel homology domain (RHD) (Pfam:PF00554), an IPT/TIG domain (Pfam:PF01833), six copies of the Ankyrin repeat (Pfam:PF00023), a Death domain (Pfam:PF00531) and a C-terminal PEST region.


CARD domain binding

Binding to a CARD (N-terminal caspase recruitment) domain, a protein-protein interaction domain that belongs to the death domain-fold superfamily. These protein molecule families are similar in structure with each consisting of six or seven anti-parallel alpha-helices that form highly specific homophilic interactions between signaling partners. CARD exists in the N-terminal prodomains of several caspases and in apoptosis-regulatory proteins and mediates the assembly of CARD-containing proteins that participate in activation or suppression of CARD carrying members of the caspase family.


response to cadmium ion

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cadmium (Cd) ion stimulus.


LDH6B_HUMAN L-lactate dehydrogenase A-like 6B (sprot)

An L-lactate dehydrogenase A-like 6B that is encoded in the genome of human.


negative regulation of retinoic acid receptor signaling pathway

Any process that stops, prevents, or reduces the frequency, rate or extent of retinoic acid receptor signaling pathway activity.


sulfatide binding

Binding to sulfatide, also known as 3-O-sulfogalactosylceramide, SM4, or sulfated galactocerebroside. Sulfatide is a class of sulfoglycolipid, which are glycolipids that contain a sulfate group.


MANF_HUMAN Mesencephalic astrocyte-derived neurotrophic factor (sprot)

A protein ARMET that is encoded in the genome of human.


BIP_HUMAN Endoplasmic reticulum chaperone BiP (sprot)

An endoplasmic reticulum chaperone BiP that is encoded in the genome of human.


ENPL_HUMAN Endoplasmin (sprot)

An endoplasmin that is encoded in the genome of human.


regulation of IRE1-mediated unfolded protein response

Any process that modulates the frequency, rate or extent of the IRE1-mediated unfolded protein response.


chitin

An aminoglycan consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues.


An N-acetyl-D-glucosaminyl group derived from N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosamine. A disaccharide group formed from the hydrolysis of chitin (a linear polymer of repeated GlcNAc units)


An N-acetyl-D-glucosaminyl group derived from N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosamine. A trisaccharide group formed from the hydrolysis of chitin (a linear polymer of repeated GlcNAc units).


retinoic acid receptor beta isoform 3 (mouse)

A retinoic acid receptor beta isoform 3 that is encoded in the genome of mouse.


retinoic acid receptor RXR-beta isoform Long (mouse)

A retinoic acid receptor RXR-beta (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P28704-1.


positive regulation of cytokine production involved in inflammatory response

Any process that activates or increases the frequency, rate or extent of cytokine production involved in inflammatory response.


white fat cell proliferation

The multiplication or reproduction of white fat cells by cell division, resulting in the expansion of their population.


PG12B_MOUSE Group XIIB secretory phospholipase A2-like protein (sprot)

A group XIIB secretory phospholipase A2-like protein that is encoded in the genome of mouse.


metamorphosis

A biological process in which an animal physically develops after birth or hatching, involving a conspicuous and relatively abrupt change in the animal's form or structure. Examples include the change from tadpole to frog, and the change from larva to adult. An example of this is found in Drosophila melanogaster.


positive regulation of circadian rhythm

Any process that activates or increases the frequency, rate or extent of a circadian rhythm behavior.


positive regulation of hemopoiesis

Any process that activates or increases the frequency, rate or extent of hemopoiesis.


synaptic receptor adaptor activity

The binding activity of a molecule that provides a physical support bridging a synaptic signaling receptor and a downstream signaling molecule.


meiotic cell cycle phase

One of the distinct periods or stages into which the meiotic cell cycle is divided. Each phase is characterized by the occurrence of specific biochemical and morphological events.


NOLC1_HUMAN Nucleolar and coiled-body phosphoprotein 1 (sprot)

A nucleolar phosphoprotein p130 that is encoded in the genome of human.


sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform mSERCA3B (mouse)

A sarcoplasmic/endoplasmic reticulum calcium ATPase 3 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q64518-1.


sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform SERCA3A (mouse)

A sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform 2 that is encoded in the genome of mouse.


sarcoplasmic/endoplasmic reticulum calcium ATPase 2 isoform 2 (mouse)

A sarcoplasmic/endoplasmic reticulum calcium ATPase 2 isoform 2 that is encoded in the genome of mouse.


Rab geranylgeranyltransferase activity

Catalysis of the reaction: 2 geranylgeranyl diphosphate + protein-cysteine = 2 S-geranylgeranyl-protein + 2 diphosphate. This reaction is the formation of two thioether linkages between the C-1 atom of the geranylgeranyl groups and two cysteine residues within the terminal sequence motifs XXCC, XCXC or CCXX. Known substrates include Ras-related GTPases of a single family and the Rab family.


HERP1_HUMAN Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein (sprot)

A homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein that is encoded in the genome of human.


IBP1_HUMAN Insulin-like growth factor-binding protein 1 (sprot)

An insulin-like growth factor-binding protein 1 that is encoded in the genome of human.


glyceryl-ether monooxygenase activity

Catalysis of the reaction: 1-alkyl-sn-glycerol + O2 + (tetrahydrobiopterin/tetrahydropteridine) = 1-hydroxyalkyl-sn-glycerol + H2O + (dihydrobiopterin/dihydropteridine).


cardiolipin synthase (CMP-forming)

Catalysis of the reaction: CDP-diacylglycerol + phosphatidylglycerol = CMP + diphosphatidylglycerol.


phosphatidylserine biosynthetic process

The chemical reactions and pathways resulting in the formation of phosphatidylserines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of L-serine.


rRNA modification

The covalent alteration of one or more nucleotides within an rRNA molecule to produce an rRNA molecule with a sequence that differs from that coded genetically.


epidermal growth factor receptor ligand maturation

Any process leading to the attainment of the full functional capacity of a ligand for an epidermal growth factor receptor. The ligand is functional when it can bind to and activate an epidermal growth factor receptor.


signaling receptor ligand precursor processing

The cleavage of a peptide bond in a precursor form of a signaling receptor ligand, resulting in the mature (active) form of the ligand.


EGF_MOUSE Pro-epidermal growth factor (sprot)

A pro-epidermal growth factor that is encoded in the genome of mouse.


EPHA1_HUMAN Ephrin type-A receptor 1 (sprot)

An ephrin type-A receptor 1 that is encoded in the genome of human.


EFNA2_HUMAN Ephrin-A2 (sprot)

An ephrin-A2 that is encoded in the genome of human.


EFNA1_HUMAN Ephrin-A1 (sprot)

An ephrin-A1 that is encoded in the genome of human.


EPHA2_HUMAN Ephrin type-A receptor 2 (sprot)

An ephrin type-A receptor 2 that is encoded in the genome of human.


EPHA3_HUMAN Ephrin type-A receptor 3 (sprot)

An ephrin type-A receptor 3 that is encoded in the genome of human.


EPHA8_HUMAN Ephrin type-A receptor 8 (sprot)

An ephrin type-A receptor 8 that is encoded in the genome of human.


EFNA3_HUMAN Ephrin-A3 (sprot)

An ephrin-A3 that is encoded in the genome of human.


EFNA4_HUMAN Ephrin-A4 (sprot)

An ephrin-A4 that is encoded in the genome of human.


EFNA5_HUMAN Ephrin-A5 (sprot)

An ephrin-A5 that is encoded in the genome of human.


EPHA5_HUMAN Ephrin type-A receptor 5 (sprot)

An ephrin type-A receptor 5 that is encoded in the genome of human.


EPHA7_HUMAN Ephrin type-A receptor 7 (sprot)

An ephrin type-A receptor 7 that is encoded in the genome of human.


EPHAA_HUMAN Ephrin type-A receptor 10 (sprot)

An ephrin type-A receptor 10 that is encoded in the genome of human.


EPHA6_HUMAN Ephrin type-A receptor 6 (sprot)

An ephrin type-A receptor 6 that is encoded in the genome of human.


free ubiquitin chain polymerization

The process of creating free ubiquitin chains, compounds composed of a large number of ubiquitin monomers. These chains are not conjugated to a protein.


protein K27-linked ubiquitination

A protein ubiquitination process in which a polymer of ubiquitin, formed by linkages between lysine residues at position 27 of the ubiquitin monomers, is added to a protein.


positive regulation of innate immune response

Any process that activates or increases the frequency, rate or extent of the innate immune response, the organism's first line of defense against infection.


protein monoubiquitination

Addition of a single ubiquitin group to a protein.


proteasomal protein catabolic process

The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds that is mediated by the proteasome.


negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway

Any process that stops, prevents, or reduces the frequency, rate, or extent of the nucleotide-binding oligomerization domain containing 2 (NOD2) pathway.


protein import into peroxisome matrix, receptor recycling

The process in which peroxisome targeting sequence receptors dissociates from cargo proteins and are returned to the cytosol.


protein import into peroxisome matrix, substrate release

The process by which the cargo protein is released into the peroxisomal matrix, following translocation across the membrane.


positive regulation of defense response to virus by host

Any host process that results in the promotion of antiviral immune response mechanisms, thereby limiting viral replication.


negative regulation of defense response to virus by host

Any host process that results in the inhibition of antiviral immune response mechanisms, thereby facilitating viral replication. The host is defined as the larger of the organisms involved in a symbiotic interaction.


positive regulation of toll-like receptor 3 signaling pathway

Any process that activates or increases the frequency, rate, or extent of toll-like receptor 3 signaling pathway.


protein K11-linked ubiquitination

A protein ubiquitination process in which ubiquitin monomers are attached to a protein, and then ubiquitin polymers are formed by linkages between lysine residues at position 11 of the ubiquitin monomers. K11-linked polyubiquitination targets the substrate protein for degradation. The anaphase-promoting complex promotes the degradation of mitotic regulators by assembling K11-linked polyubiquitin chains.


stress granule disassembly

The disaggregation of a stress granule into its constituent protein and RNA parts.


positive regulation of toll-like receptor 4 signaling pathway

Any process that activates or increases the frequency, rate, or extent of toll-like receptor 4 signaling pathway.


negative regulation of toll-like receptor 3 signaling pathway

Any process that stops, prevents, or reduces the frequency, rate, or extent of toll-like receptor 3 signaling pathway.


negative regulation of cilium assembly

Any process that stops, prevents or reduces the frequency, rate or extent of cilium assembly.


translation elongation factor activity

Functions in chain elongation during polypeptide synthesis at the ribosome.


translation release factor activity

Involved in catalyzing the release of a nascent polypeptide chain from a ribosome.


Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.


ubiquitin

A proteolytic cleavage product that gives rise to a protein that corresponds to the stand-alone version of the Ubiquitin (Pfam:PF00240) domain. Example: UniProtKB:P0CG48, 1-76.


RS20_HUMAN Small ribosomal subunit protein uS10 (sprot)

A 40S ribosomal protein S20 that is encoded in the genome of human.


G3BP1_HUMAN Ras GTPase-activating protein-binding protein 1 (sprot)

A Ras GTPase-activating protein-binding protein 1 that is encoded in the genome of human.


RS3_HUMAN Small ribosomal subunit protein uS3 (sprot)

A 40S ribosomal protein S3 that is encoded in the genome of human.


Toll-like receptor 3 isoform h1 (human)

A Toll-like receptor 3 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O15455-1.


BIRC5_HUMAN Baculoviral IAP repeat-containing protein 5 (sprot)

A baculoviral IAP repeat-containing protein 5 that is encoded in the genome of human.


ELOB_HUMAN Elongin-B (sprot)

An elongin-B that is encoded in the genome of human.


ELOC_HUMAN Elongin-C (sprot)

An elongin-C that is encoded in the genome of human.


SHPRH_HUMAN E3 ubiquitin-protein ligase SHPRH (sprot)

An E3 ubiquitin-protein ligase SHPRH that is encoded in the genome of human.


HLTF_HUMAN Helicase-like transcription factor (sprot)

A helicase-like transcription factor that is encoded in the genome of human.


R144A_HUMAN E3 ubiquitin-protein ligase RNF144A (sprot)

An E3 ubiquitin-protein ligase RNF144A that is encoded in the genome of human.


RN181_HUMAN E3 ubiquitin-protein ligase RNF181 (sprot)

An E3 ubiquitin-protein ligase RNF181 that is encoded in the genome of human.


WAC_HUMAN WW domain-containing adapter protein with coiled-coil (sprot)

A WW domain-containing adapter protein with coiled-coil that is encoded in the genome of human.


US11_HCMVA Unique short US11 glycoprotein (sprot)


ubiquitin-conjugating enzyme E2 J2 isoform h1 (human)

A ubiquitin-conjugating enzyme E2 J2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q8N2K1-1.


BACH1_HUMAN Transcription regulator protein BACH1 (sprot)

A transcription regulator protein BACH1 that is encoded in the genome of human.


FXL17_HUMAN F-box/LRR-repeat protein 17 (sprot)

An F-box/LRR-repeat protein 17 that is encoded in the genome of human.


H2B1K_HUMAN Histone H2B type 1-K (sprot)

A histone H2B type 1-K that is encoded in the genome of human.


H2B1J_HUMAN Histone H2B type 1-J (sprot)

A histone H2B type 1-J that is encoded in the genome of human.


H2B1O_HUMAN Histone H2B type 1-O (sprot)

A histone H2B type 1-O that is encoded in the genome of human.


H2B1B_HUMAN Histone H2B type 1-B (sprot)

A histone H2B type 1-B that is encoded in the genome of human.


H2B1D_HUMAN Histone H2B type 1-D (sprot)

A histone H2B type 1-D that is encoded in the genome of human.


H2B1C_HUMAN Histone H2B type 1-C/E/F/G/I (sprot)

A histone H2B type 1-C/E/F/G/I that is encoded in the genome of human.


H2B1H_HUMAN Histone H2B type 1-H (sprot)

A histone H2B type 1-H that is encoded in the genome of human.


H2B1A_HUMAN Histone H2B type 1-A (sprot)

A histone H2B type 1-A that is encoded in the genome of human.


H2B1N_HUMAN Histone H2B type 1-N (sprot)

A histone H2B type 1-N that is encoded in the genome of human.


H2B1M_HUMAN Histone H2B type 1-M (sprot)

A histone H2B type 1-M that is encoded in the genome of human.


H2B1L_HUMAN Histone H2B type 1-L (sprot)

A histone H2B type 1-L that is encoded in the genome of human.


Q9MY60_HUMAN MHC Class I antigen (B60) (Fragment) (trembl)


RNF10_HUMAN E3 ubiquitin-protein ligase RNF10 (sprot)

A RING finger protein 10 that is encoded in the genome of human.


BRAP_HUMAN BRCA1-associated protein (sprot)

A BRCA1-associated protein that is encoded in the genome of human.


TM129_HUMAN E3 ubiquitin-protein ligase TM129 (sprot)

An E3 ubiquitin-protein ligase TM129 that is encoded in the genome of human.


RFFL_HUMAN E3 ubiquitin-protein ligase rififylin (sprot)

An E3 ubiquitin-protein ligase rififylin that is encoded in the genome of human.


ASCC3_HUMAN Activating signal cointegrator 1 complex subunit 3 (sprot)

An activating signal cointegrator 1 complex subunit 3 that is encoded in the genome of human.


ABCE1_HUMAN ATP-binding cassette sub-family E member 1 (sprot)

An ATP-binding cassette sub-family E member 1 that is encoded in the genome of human.


endonucleolytic cleavage in ITS1 upstream of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

Endonucleolytic cleavage within Internal Transcribed Spacer 1 (ITS1) upstream of the 5.8S rRNA derived from an originally tricistronic rRNA transcript that contained the Small Subunit (SSU) rRNA, the 5.8S rRNA, and the Large Subunit (LSU) rRNA in that order from 5' to 3' along the primary transcript. In S. cerevisiae, this endonucleolytic cleavage within ITS1 initiates the maturation of the LSU and the 5.8S rRNAs.


PPIL2_HUMAN RING-type E3 ubiquitin-protein ligase PPIL2 (sprot)

A RING-type E3 ubiquitin-protein ligase PPIL2 that is encoded in the genome of human.


ZMAT2_HUMAN Zinc finger matrin-type protein 2 (sprot)

A zinc finger matrin-type protein 2 that is encoded in the genome of human.


YJU2_HUMAN Splicing factor YJU2 (sprot)

A splicing factor YJU2 that is encoded in the genome of human.


WBP4_HUMAN WW domain-binding protein 4 (sprot)

A WW domain-binding protein 4 that is encoded in the genome of human.


CASC3_HUMAN Protein CASC3 (sprot)

A protein CASC3 that is encoded in the genome of human.


CWC27_HUMAN Spliceosome-associated protein CWC27 homolog (sprot)

A spliceosome-associated protein CWC27 homolog that is encoded in the genome of human.


GPKOW_HUMAN G-patch domain and KOW motifs-containing protein (sprot)

A G-patch domain and KOW motifs-containing protein that is encoded in the genome of human.


R113A_HUMAN E3 ubiquitin-protein ligase RNF113A (sprot)

An E3 ubiquitin-protein ligase RNF113A that is encoded in the genome of human.


REN3B_HUMAN Regulator of nonsense transcripts 3B (sprot)

A regulator of nonsense transcripts 3B that is encoded in the genome of human.


WDR70_HUMAN WD repeat-containing protein 70 (sprot)

A WD repeat-containing protein 70 that is encoded in the genome of human.


CWC25_HUMAN Pre-mRNA-splicing factor CWC25 homolog (sprot)

A pre-mRNA-splicing factor CWC25 homolog that is encoded in the genome of human.


DHX35_HUMAN Probable ATP-dependent RNA helicase DHX35 (sprot)

A probable ATP-dependent RNA helicase DHX35 that is encoded in the genome of human.


MFAP1_HUMAN Microfibrillar-associated protein 1 (sprot)

A microfibrillar-associated protein 1 that is encoded in the genome of human.


PPIL4_HUMAN Peptidyl-prolyl cis-trans isomerase-like 4 (sprot)

A peptidyl-prolyl cis-trans isomerase-like 4 that is encoded in the genome of human.


GPTC1_HUMAN G patch domain-containing protein 1 (sprot)

A G patch domain-containing protein 1 that is encoded in the genome of human.


NSRP1_HUMAN Nuclear speckle splicing regulatory protein 1 (sprot)

A nuclear speckle splicing regulatory protein 1 that is encoded in the genome of human.


PQBP1_HUMAN Polyglutamine-binding protein 1 (sprot)

A polyglutamine-binding protein 1 that is encoded in the genome of human.


PP1R8_HUMAN Nuclear inhibitor of protein phosphatase 1 (sprot)

A nuclear inhibitor of protein phosphatase 1 that is encoded in the genome of human.


TCRG1_HUMAN Transcription elongation regulator 1 (sprot)

A transcription elongation regulator 1 that is encoded in the genome of human.


PRP18_HUMAN Pre-mRNA-splicing factor 18 (sprot)

A pre-mRNA-splicing factor 18 that is encoded in the genome of human.


RBM5_HUMAN RNA-binding protein 5 (sprot)

An RNA-binding protein 5 that is encoded in the genome of human.


UBL5_HUMAN Ubiquitin-like protein 5 (sprot)

A ubiquitin-like protein 5 that is encoded in the genome of human.


IF4A3_HUMAN Eukaryotic initiation factor 4A-III (sprot)

A eukaryotic initiation factor 4A-III that is encoded in the genome of human.


PR38A_HUMAN Pre-mRNA-splicing factor 38A (sprot)

A pre-mRNA-splicing factor 38A that is encoded in the genome of human.


DNJC8_HUMAN DnaJ homolog subfamily C member 8 (sprot)

A DnaJ homolog subfamily C member 8 that is encoded in the genome of human.


CCAR1_HUMAN Cell division cycle and apoptosis regulator protein 1 (sprot)

A cell division cycle and apoptosis regulator protein 1 that is encoded in the genome of human.


WBP11_HUMAN WW domain-binding protein 11 (sprot)

A WW domain-binding protein 11 that is encoded in the genome of human.


DHX9_HUMAN ATP-dependent RNA helicase A (sprot)

An ATP-dependent RNA helicase A that is encoded in the genome of human.


SMU1_HUMAN WD40 repeat-containing protein SMU1 (sprot)

A WD40 repeat-containing protein SMU1 that is encoded in the genome of human.


UBP39_HUMAN Ubiquitin carboxyl-terminal hydrolase 39 (sprot)

A U4/U6.U5 tri-snRNP-associated protein 2 that is encoded in the genome of human.


RBM39_HUMAN RNA-binding protein 39 (sprot)

An RNA-binding protein 39 that is encoded in the genome of human.


LC7L3_HUMAN Luc7-like protein 3 (sprot)

A cisplatin resistance-associated overexpressed protein that is encoded in the genome of human.


SNUT1_HUMAN U4/U6.U5 tri-snRNP-associated protein 1 (sprot)

A U4/U6.U5 tri-snRNP-associated protein 1 that is encoded in the genome of human.


RED_HUMAN Protein Red (sprot)

A protein Red that is encoded in the genome of human.


SNR27_HUMAN U4/U6.U5 small nuclear ribonucleoprotein 27 kDa protein (sprot)

A U4/U6.U5 small nuclear ribonucleoprotein 27 kDa protein that is encoded in the genome of human.


RBM25_HUMAN RNA-binding protein 25 (sprot)

An RNA-binding protein 25 that is encoded in the genome of human.


RBM42_HUMAN RNA-binding protein 42 (sprot)

An RNA-binding protein 42 that is encoded in the genome of human.


SF01_HUMAN Splicing factor 1 (sprot)

A splicing factor 1 that is encoded in the genome of human.


RBM7_HUMAN RNA-binding protein 7 (sprot)

An RNA-binding protein 7 that is encoded in the genome of human.


PR40A_HUMAN Pre-mRNA-processing factor 40 homolog A (sprot)

A pre-mRNA-processing factor 40 homolog A that is encoded in the genome of human.


PRP4B_HUMAN Serine/threonine-protein kinase PRP4 homolog (sprot)

A serine/threonine-protein kinase PRP4 that is encoded in the genome of human.


TXN4A_HUMAN Thioredoxin-like protein 4A (sprot)

A thioredoxin-like protein 4A that is encoded in the genome of human.


PRP6_HUMAN Pre-mRNA-processing factor 6 (sprot)

A pre-mRNA-processing factor 6 that is encoded in the genome of human.


post-transcriptional regulation of gene expression

Any process that modulates the frequency, rate or extent of gene expression after the production of an RNA transcript.


regulation of Golgi organization

Any process that modulates the frequency, rate or extent of Golgi organization.


protein localization to Golgi membrane

A process in which a protein is transported to, or maintained in, a location within a Golgi membrane.


mitochondrion inheritance

The distribution of mitochondria, including the mitochondrial genome, into daughter cells after mitosis or meiosis, mediated by interactions between mitochondria and the cytoskeleton.


endoplasmic reticulum inheritance

The partitioning of endoplasmic reticulum between daughter cells at cell division.


Golgi inheritance

The partitioning of Golgi apparatus between daughter cells at cell division.


Golgi distribution to daughter cells

Any process in which disassembled Golgi vesicles are localized into daughter cells upon cell division.


regulation of carbohydrate metabolic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving carbohydrates.


cytolysis in another organism

The killing by an organism of a cell in another organism by means of the rupture of cell membranes and the loss of cytoplasm.


adenylate cyclase-modulating G protein-coupled receptor signaling pathway

A G protein-coupled receptor signaling pathway in which the signal is transmitted via the activation or inhibition of adenylyl cyclase activity and a subsequent change in the intracellular concentration of cyclic AMP (cAMP).


NAD-dependent protein depalmitoylase activity

Catalysis of the reaction: N6-octadecanoyl-L-lysyl-[protein] + NAD+ + H2O = octadecanoyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide.


3'-5' RNA helicase activity

Unwinding of an RNA helix in the 3' to 5' direction, driven by ATP hydrolysis.


negative regulation of GTPase activity

Any process that stops or reduces the rate of GTP hydrolysis by a GTPase.


Catalysis of the reaction: 10-formyltetrahydrofolate + L-methionyl-tRNA + H2O = tetrahydrofolate + N-formylmethionyl-tRNA.


translation termination factor activity

Functions in the termination of translation.


mitochondrial inner boundary membrane

The portion of the mitochondrial inner membrane that is not invaginated to form cristae. The inner boundary membrane lies parallel to the outer membrane.


PELO_HUMAN Protein pelota homolog (sprot)

A protein pelota that is encoded in the genome of human.


SH3G2_HUMAN Endophilin-A1 (sprot)

An endophilin-A1 that is encoded in the genome of human.


TBC20_HUMAN TBC1 domain family member 20 (sprot)

A TBC1 domain family member 20 that is encoded in the genome of human.


IF3M_HUMAN Translation initiation factor IF-3, mitochondrial (sprot)

A translation initiation factor IF-3, mitochondrial that is encoded in the genome of human.


IF2M_HUMAN Translation initiation factor IF-2, mitochondrial (sprot)

A translation initiation factor IF-2, mitochondrial that is encoded in the genome of human.


RRFM_HUMAN Ribosome-recycling factor, mitochondrial (sprot)

A ribosome-recycling factor, mitochondrial that is encoded in the genome of human.


RASL2_HUMAN Ras GTPase-activating protein 4 (sprot)

A Ras GTPase-activating protein 4 that is encoded in the genome of human.


RASL1_HUMAN RasGAP-activating-like protein 1 (sprot)

A RasGAP-activating-like protein 1 that is encoded in the genome of human.


RASA3_HUMAN Ras GTPase-activating protein 3 (sprot)

A Ras GTPase-activating protein 3 that is encoded in the genome of human.


RASA2_HUMAN Ras GTPase-activating protein 2 (sprot)

A Ras GTPase-activating protein 2 that is encoded in the genome of human.


DAB2P_HUMAN Disabled homolog 2-interacting protein (sprot)

A disabled homolog 2-interacting protein that is encoded in the genome of human.


RASL3_HUMAN RAS protein activator like-3 (sprot)

A RAS protein activator like-3 that is encoded in the genome of human.


SYGP1_HUMAN Ras/Rap GTPase-activating protein SynGAP (sprot)

A Ras/Rap GTPase-activating protein SynGAP that is encoded in the genome of human.


NGAP_HUMAN Ras GTPase-activating protein nGAP (sprot)

A Ras GTPase-activating protein nGAP that is encoded in the genome of human.


HBS1L_HUMAN HBS1-like protein (sprot)

An HBS1-like protein that is encoded in the genome of human.


ERF3A_HUMAN Eukaryotic peptide chain release factor GTP-binding subunit ERF3A (sprot)

A eukaryotic peptide chain release factor GTP-binding subunit ERF3A that is encoded in the genome of human.


RRF2M_HUMAN Ribosome-releasing factor 2, mitochondrial (sprot)

An elongation factor G 2, mitochondrial that is encoded in the genome of human.


K1KB5_MOUSE Kallikrein 1-related peptidase b5 (sprot)

A kallikrein 1-related peptidase b5 that is encoded in the genome of mouse.


partitioning defective 3 homolog isoform 3 (mouse)

A partitioning defective 3 homolog (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q99NH2-3.


oocyte animal/vegetal axis specification

The establishment, maintenance and elaboration of the animal/vegetal axis in the oocyte. The animal/vegetal axis of an oocyte is defined by the placement of the nucleus in the oocyte and can sometimes be identified by the asymmetric placement of other substances such as yolk in the oocyte. The pole of the egg that is closest to the nucleus defines the animal end, with the axis passing through the nucleus.


nasal mucus

Mucus produced in the nasal cavity, by the respiratory segment of the nasal mucosa.


outer dynein arm assembly

The aggregation, arrangement and bonding together of a set of components to form an axonemal dynein outer arm, an outer arm structure present on the outer doublet microtubules of ciliary and flagellar axonemes.


ecto-epithelial cell of viscerocranial mucosa

An epithelial cell of the mucosa associated with facial skeleton.


respiratory ciliated cell

A ciliated cell of the respiratory system. Ciliated cells are present in airway epithelium.


establishment of left/right asymmetry

The initial formation of the type asymmetry in an organism's body plan or part of an organism with respect to the left and right halves.


apical cytoplasm

The region of the cytoplasm located at the apical side of the cell. Used in reference to animal polarized epithelial cells.


subapical part of cell

The region of a polarized cell that is just below the apical region. For example, in a polarized epithelial cell, the apical region has an exposed surface and lies opposite to the basal lamina that separates the epithelium from other tissue so the subapical region is further from the exposed surface and closer to the basal lamina.


ciliary transition fiber

A nine-bladed, propeller-like protein complex that links the distal end of the basal body and the cilium to the plasma membrane. Functions in protein sorting and gating (i.e. active and passive transport of proteins in and out of the cilium).


multi-ciliated epithelial cell differentiation

The process in which a relatively unspecialized cell acquires the specialized features of a multi-ciliated epithelial cell.


zonula adherens assembly

Assembly of the zonula adherens, a cell-cell adherens junction which forms a continuous belt near the apex of epithelial cells.


maintenance of ciliary planar beating movement pattern

Any process involved in maintaining the planar beating pattern of ciliary movement pattern. Connection between the outer doublets and the central pair via the radial spokes constrains ciliary movement to the planar beating pattern. Cilia that lack this connection, such as those in the embryonic node or Kupfer's vesicle, display radial movement.


positive regulation of motile cilium assembly

Any process that activates or increases the frequency, rate or extent of motile cilium assembly.


dynein heavy chain binding

Binding to a heavy chain of the dynein complex.


DYHC1_MOUSE Cytoplasmic dynein 1 heavy chain 1 (sprot)

A cytoplasmic dynein 1 heavy chain 1 that is encoded in the genome of mouse.


cyclic nucleotide-gated monoatomic ion channel activity

Enables the transmembrane transfer of an ion by a channel that opens when a cyclic nucleotide has been bound by the channel complex or one of its constituent parts.


membrane hyperpolarization

The process in which membrane potential increases with respect to its steady-state potential, usually from negative potential to a more negative potential. For example, during the repolarization phase of an action potential the membrane potential often becomes more negative or hyperpolarized before returning to the steady-state resting potential.


voltage-gated monoatomic ion channel activity

Enables the transmembrane transfer of an ion by a voltage-gated channel. An ion is an atom or group of atoms carrying an electric charge by virtue of having gained or lost one or more electrons. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded.


detection of cAMP

The series of events in which a cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate) stimulus is received by a cell and converted into a molecular signal; cAMP is the nucleotide cyclic AMP.


neuroepithelial stem cell

The stem cell from which glial precursor cell arises from.


anterior neural tube closure

The step in the formation of the neural tube, where the paired anterior neural folds are brought together and fuse at the dorsal midline.


spinal cord motor neuron differentiation

The process in which neuroepithelial cells in the ventral neural tube acquire specialized structural and/or functional features of motor neurons. Motor neurons innervate an effector (muscle or glandular) tissue and are responsible for transmission of motor impulses from the brain to the periphery. Differentiation includes the processes involved in commitment of a cell to a specific fate.


planar cell polarity pathway involved in neural tube closure

The series of molecular signals initiated by binding of a Wnt protein to a receptor on the surface of the target cell where activated receptors signal via downstream effectors that modulates the establishment of planar polarity contributing to neural tube closure.


basal protein localization

Any process in which a protein is transported to, or maintained in, basal regions of the cell.


regulation of protein maturation

Any process that modulates the frequency, rate or extent of protein maturation.


autonomic ganglion

Ganglion that has dendrites that form a junction between autonomic nerves originating from the central nervous system and autonomic nerves innervating their target organs in the periphery. There are two subtypes, sympathetic ganglion and parasympathetic ganglion.


parasympathetic nerve

A nerve that is part of a parasympathetic nervous system [Automatically generated definition].


glial cell apoptotic process

Any apoptotic process in a glial cell, a non-neuronal cell of the nervous system.


vitamin metabolic process

The chemical reactions and pathways involving vitamins. Vitamin is a general term for a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body. Vitamins may be water-soluble or fat-soluble and usually serve as components of coenzyme systems.


acetylcholine metabolic process

The chemical reactions and pathways involving acetylcholine, the acetic acid ester of the organic base choline. Acetylcholine is a major neurotransmitter and neuromodulator both in the central and peripheral nervous systems. It also acts as a paracrine signal in various non-neural tissues.


corticospinal neuron axon guidance

The process in which the migration of an axon growth cone of a neuron that is part of the corticospinal tract is directed from the cerebral cortex layer V to the spinal cord dorsal funiculus in response to a combination of attractive and repulsive cues.


negative regulation of cyclin-dependent protein serine/threonine kinase activity

Any process that stops, prevents, or reduces the frequency, rate or extent of cyclin-dependent protein serine/threonine kinase activity.


response to UV

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ultraviolet radiation (UV light) stimulus. Ultraviolet radiation is electromagnetic radiation with a wavelength in the range of 10 to 380 nanometers.


negative regulation of B cell proliferation

Any process that stops, prevents or reduces the rate or extent of B cell proliferation.


negative regulation of activated T cell proliferation

Any process that stops, prevents or reduces the rate or extent of activated T cell proliferation.


tendon formation

The process that gives rise to a tendon. This process pertains to the initial formation of a tendon from unspecified parts.


face development

The biological process whose specific outcome is the progression of a face from an initial condition to its mature state. The face is the ventral division of the head.


respiratory tube development

The process whose specific outcome is the progression of the respiratory tube over time, from its formation to the mature structure. The respiratory tube is assumed to mean any tube in the respiratory tract.


epithelial cell morphogenesis involved in placental branching

The change in form (cell shape and size) that occurs when a trophoblast cell elongates to contribute to the branching of the placenta.


lung lobe morphogenesis

The process in which the anatomical structures of a lung lobe are generated and organized. A lung lobe is a projection that extends from the lung.


cellular localization

A cellular localization process whereby a substance or cellular entity, such as a protein complex or organelle, is transported to, and/or maintained in, a specific location within a cell including the localization of substances or cellular entities to the cell membrane.


meiotic cell cycle process involved in oocyte maturation

Any meiotic cell cycle process that is involved in oocyte maturation.


regulation of MAPK cascade

Any process that modulates the frequency, rate or extent of signal transduction mediated by the MAP kinase (MAPK) cascade.


fibroblast growth factor receptor binding

Binding to a fibroblast growth factor receptor (FGFR).


neutrophil migration

The movement of a neutrophil within or between different tissues and organs of the body.


regulation of neutrophil chemotaxis

Any process that modulates the frequency, rate, or extent of neutrophil chemotaxis. Neutrophil chemotaxis is the directed movement of a neutrophil cell, the most numerous polymorphonuclear leukocyte found in the blood, in response to an external stimulus, usually an infection or wounding.


regulation of sarcomere organization

Any process that modulates the rate, frequency or extent of myofibril assembly by organization of muscle actomyosin into sarcomeres. The sarcomere is the repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs.


regulation of mitochondrion organization

Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a mitochondrion.


neuromast regeneration

The regrowth of a neuromast following its loss or destruction.


undifferentiated genital tubercle

The embryonic anlage of the external genitalia, which emerges as paired swellings ventral to the cloacal membrane, is proposed to be derived from all three germ layers, and gives rise to the penis, clitoris, scrotum, labia, and foreskin.


lipid droplet formation

A process that results in the assembly, arrangement of constituent parts of a lipid droplet.


cytosolic lipolysis

The chemical reactions and pathways resulting in the breakdown of lipid droplets and hydrolysis of stored triglycerides occurring through the orchestrated activation of cytosolic lipases.


diacylglycerol metabolic process

The chemical reactions and pathways involving diacylglycerol, a glyceride in which any two of the R groups (positions not specified) are acyl groups while the remaining R group can be either H or an alkyl group.


regulation of multicellular organism growth

Any process that modulates the frequency, rate or extent of growth of the body of an organism so that it reaches its usual body size.


mammary gland development

The process whose specific outcome is the progression of the mammary gland over time, from its formation to the mature structure. The mammary gland is a large compound sebaceous gland that in female mammals is modified to secrete milk. Its development starts with the formation of the mammary line and ends as the mature gland cycles between nursing and weaning stages.


glandular epithelial cell maturation

The developmental process, independent of morphogenetic (shape) change, that is required for a glandular epithelial cell to attain its fully functional state. A glandular epithelial cell is a columnar/cuboidal epithelial cell is a cell found in a two dimensional sheet with a free surface exposed to the lumen of a gland.


ganglion of central nervous system

A ganglion that is part of a central nervous system [Automatically generated definition].


optic chiasma

A decussation of the diencephalon where the fibers of the optic nerve cross.


spinal accessory motor neuron

A motor neuron that is located in the cervical region of the spinal cord and selectively innervates the sternocleidmastoid or trapezius muscle. Unlike other motor neurons, they extend axons dorsally along lateral margins of the spinal cord.


IAPP_MOUSE Islet amyloid polypeptide (sprot)

An islet amyloid polypeptide that is encoded in the genome of mouse.


clathrin adaptor complex

A membrane coat adaptor complex that links clathrin to a membrane.


palmitoleoyltransferase activity

Catalysis of the transfer of a palmitoleyl group, a 16-carbon monounsaturated fatty acid (C16:1), to an acceptor molecule.


calyx of Held

The terminal specialization of a calyciferous axon which forms large synapses in the mammalian auditory central nervous system.


negative regulation of synaptic vesicle exocytosis

Any process that stops, prevents or reduces the frequency, rate or extent of synaptic vesicle exocytosis.


D7PBZ9_CARAU Syntaxin 3B (Fragment) (trembl)


ubiquitin ligase complex

A protein complex that includes a ubiquitin-protein ligase and enables ubiquitin protein ligase activity. The complex also contains other proteins that may confer substrate specificity on the complex.


regulation of glial cell differentiation

Any process that modulates the frequency, rate or extent of glia cell differentiation.


embryonic camera-type eye development

The process occurring during the embryonic phase whose specific outcome is the progression of the eye over time, from its formation to the mature structure.


optic cup formation involved in camera-type eye development

The developmental process pertaining to the initial formation of the optic cup, a two-walled vesicle formed from the optic vesicle.


regulation of receptor internalization

Any process that modulates the frequency, rate or extent of receptor internalization.


notochord cell development

The process whose specific outcome is the progression of a notochord cell over time, from its formation to its mature structure. Cell development does not include the steps involved in committing a cell to a specific fate.


rhombomere development

The process whose specific outcome is the progression of the rhombomere over time, from its formation to the mature structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates.