RHG35_HUMAN Rho GTPase-activating protein 35 (sprot)

A Rho GTPase-activating protein 35 that is encoded in the genome of human.


NSF_HUMAN Vesicle-fusing ATPase (sprot)

A vesicle-fusing ATPase that is encoded in the genome of human.


ARHG1_HUMAN Rho guanine nucleotide exchange factor 1 (sprot)

A Rho guanine nucleotide exchange factor 1 that is encoded in the genome of human.


ANGI_HUMAN Angiogenin (sprot)

An angiogenin that is encoded in the genome of human.


PDE4A_HUMAN cAMP-specific 3',5'-cyclic phosphodiesterase 4A (sprot)

A cAMP-specific 3',5'-cyclic phosphodiesterase 4A that is encoded in the genome of human.


AGO2_HUMAN Protein argonaute-2 (sprot)

A protein argonaute-2 that is encoded in the genome of human.


PAN2_HUMAN PAN2-PAN3 deadenylation complex catalytic subunit PAN2 (sprot)

A PAN2-PAN3 deadenylation complex catalytic subunit PAN2 that is encoded in the genome of human.


XRN1_HUMAN 5'-3' exoribonuclease 1 (sprot)

A 5'-3' exoribonuclease 1 that is encoded in the genome of human.


DCP2_HUMAN m7GpppN-mRNA hydrolase (sprot)

An m7GpppN-mRNA hydrolase that is encoded in the genome of human.


DCPS_HUMAN m7GpppX diphosphatase (sprot)

A scavenger mRNA-decapping enzyme DcpS that is encoded in the genome of human.


5NT3B_HUMAN 7-methylguanosine phosphate-specific 5'-nucleotidase (sprot)

A 7-methylguanosine phosphate-specific 5'-nucleotidase that is encoded in the genome of human.


RRP44_HUMAN Exosome complex exonuclease RRP44 (sprot)

An exosome complex exonuclease RRP44 that is encoded in the genome of human.


MPI_HUMAN Mannose-6-phosphate isomerase (sprot)

A mannose-6-phosphate isomerase that is encoded in the genome of human.


NAGA_HUMAN N-acetylglucosamine-6-phosphate deacetylase (sprot)

A eukaryotic-type N-acetylglucosamine-6-phosphate deacetylase that is encoded in the genome of human.


AGM1_HUMAN Phosphoacetylglucosamine mutase (sprot)

A phosphoacetylglucosamine mutase that is encoded in the genome of human.


HECW1_HUMAN E3 ubiquitin-protein ligase HECW1 (sprot)

An E3 ubiquitin-protein ligase HECW1 that is encoded in the genome of human.


NUD14_HUMAN Uridine diphosphate glucose pyrophosphatase NUDT14 (sprot)

A uridine diphosphate glucose pyrophosphatase NUDT14 that is encoded in the genome of human.


ENASE_HUMAN Cytosolic endo-beta-N-acetylglucosaminidase (sprot)

A cytosolic endo-beta-N-acetylglucosaminidase that is encoded in the genome of human.


NGLY1_HUMAN Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase (sprot)

A peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase that is encoded in the genome of human.


DPH7_HUMAN Diphthine methyltransferase (sprot)

A diphthine methyltransferase that is encoded in the genome of human.


DPH6_HUMAN Diphthine--ammonia ligase (sprot)

A diphthine--ammonia ligase that is encoded in the genome of human.


DPH2_HUMAN 2-(3-amino-3-carboxypropyl)histidine synthase subunit 2 (sprot)

A 2-(3-amino-3-carboxypropyl)histidine synthase subunit 2 that is encoded in the genome of human.


DPH5_HUMAN Diphthine methyl ester synthase (sprot)

A diphthine methyl ester synthase that is encoded in the genome of human.


KGUA_HUMAN Guanylate kinase (sprot)

A guanylate kinase that is encoded in the genome of human.


BAG4_HUMAN BAG family molecular chaperone regulator 4 (sprot)

A BAG family molecular chaperone regulator 4 that is encoded in the genome of human.


OTUL_HUMAN Ubiquitin thioesterase otulin (sprot)

A ubiquitin thioesterase otulin that is encoded in the genome of human.


NOS1_HUMAN Nitric oxide synthase 1 (sprot)

A nitric oxide synthase, brain that is encoded in the genome of human.


PIWL2_HUMAN Piwi-like protein 2 (sprot)

A piwi-like protein 2 that is encoded in the genome of human.


HENMT_HUMAN Small RNA 2'-O-methyltransferase (sprot)

A small RNA 2'-O-methyltransferase that is encoded in the genome of human.


ATAT_HUMAN Alpha-tubulin N-acetyltransferase 1 (sprot)

An alpha-tubulin N-acetyltransferase 1 that is encoded in the genome of human.


RAB3I_HUMAN Rab-3A-interacting protein (sprot)

A Rab-3A-interacting protein that is encoded in the genome of human.


INP5E_HUMAN Phosphatidylinositol polyphosphate 5-phosphatase type IV (sprot)

A phosphatidylinositol polyphosphate 5-phosphatase type IV that is encoded in the genome of human.


TIGAR_HUMAN Fructose-2,6-bisphosphatase TIGAR (sprot)

A fructose-2,6-bisphosphatase TIGAR that is encoded in the genome of human.


PIMT_HUMAN Protein-L-isoaspartate(D-aspartate) O-methyltransferase (sprot)

A protein-L-isoaspartate(D-aspartate) O-methyltransferase that is encoded in the genome of human.


MSRA_HUMAN Mitochondrial peptide methionine sulfoxide reductase (sprot)

A peptide methionine sulfoxide reductase that is encoded in the genome of human.


PTN7_HUMAN Tyrosine-protein phosphatase non-receptor type 7 (sprot)

A tyrosine-protein phosphatase non-receptor type 7 that is encoded in the genome of human.


SRGP2_HUMAN SLIT-ROBO Rho GTPase-activating protein 2 (sprot)

A SLIT-ROBO Rho GTPase-activating protein 2 that is encoded in the genome of human.


PSDE_HUMAN 26S proteasome non-ATPase regulatory subunit 14 (sprot)

A 26S proteasome non-ATPase regulatory subunit 14 that is encoded in the genome of human.


OTU7B_HUMAN OTU domain-containing protein 7B (sprot)

An OTU domain-containing protein 7B that is encoded in the genome of human.


OTU7A_HUMAN OTU domain-containing protein 7A (sprot)

An OTU domain-containing protein 7A that is encoded in the genome of human.


OTUD5_HUMAN OTU domain-containing protein 5 (sprot)

An OTU domain-containing protein 5 that is encoded in the genome of human.


DNJB1_HUMAN DnaJ homolog subfamily B member 1 (sprot)

A DnaJ homolog subfamily B member 1 that is encoded in the genome of human.


UBP5_HUMAN Ubiquitin carboxyl-terminal hydrolase 5 (sprot)

A ubiquitin carboxyl-terminal hydrolase 5 that is encoded in the genome of human.


UBP2_HUMAN Ubiquitin carboxyl-terminal hydrolase 2 (sprot)

A ubiquitin carboxyl-terminal hydrolase 2 that is encoded in the genome of human.


UBP11_HUMAN Ubiquitin carboxyl-terminal hydrolase 11 (sprot)

A ubiquitin carboxyl-terminal hydrolase 11 that is encoded in the genome of human.


UBP19_HUMAN Ubiquitin carboxyl-terminal hydrolase 19 (sprot)

A ubiquitin carboxyl-terminal hydrolase 19 that is encoded in the genome of human.


UBP33_HUMAN Ubiquitin carboxyl-terminal hydrolase 33 (sprot)

A ubiquitin carboxyl-terminal hydrolase 33 that is encoded in the genome of human.


DUS2L_HUMAN tRNA-dihydrouridine(20) synthase [NAD(P)+]-like (sprot)

A tRNA-dihydrouridine synthase 2-like that is encoded in the genome of human.


NSUN6_HUMAN tRNA (cytosine(72)-C(5))-methyltransferase NSUN6 (sprot)

A tRNA (cytosine(72)-C(5))-methyltransferase NSUN6 that is encoded in the genome of human.


THG1_HUMAN Probable tRNA(His) guanylyltransferase (sprot)

A probable tRNA(His) guanylyltransferase that is encoded in the genome of human.


MOD5_HUMAN tRNA dimethylallyltransferase (sprot)

A eukaryotic tRNA dimethylallyltransferase that is encoded in the genome of human.


TRM7_HUMAN tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase (sprot)

A ribosomal RNA methyltransferase 1 that is encoded in the genome of human.


PUS3_HUMAN tRNA pseudouridine(38/39) synthase (sprot)

A tRNA pseudouridine synthase 3 that is encoded in the genome of human.


TRM11_HUMAN tRNA (guanine(10)-N2)-methyltransferase homolog (sprot)

A tRNA guanosine-2'-O-methyltransferase TRM11 that is encoded in the genome of human.


TRM44_HUMAN Probable tRNA (uracil-O(2)-)-methyltransferase (sprot)

A probable tRNA (uracil-O(2)-)-methyltransferase that is encoded in the genome of human.


FCSK_HUMAN L-fucose kinase (sprot)

An L-fucose kinase that is encoded in the genome of human.


FPGT_HUMAN Fucose-1-phosphate guanylyltransferase (sprot)

A fucose-1-phosphate guanylyltransferase (human), isoforms 2, 5, and 6.


GMDS_HUMAN GDP-mannose 4,6 dehydratase (sprot)

A GDP-mannose 4,6 dehydratase that is encoded in the genome of human.


RNZ2_HUMAN Zinc phosphodiesterase ELAC protein 2 (sprot)

A zinc phosphodiesterase ELAC protein 2 that is encoded in the genome of human.


TSR3_HUMAN 18S rRNA aminocarboxypropyltransferase (sprot)

An 18S rRNA aminocarboxypropyltransferase that is encoded in the genome of human.


NOB1_HUMAN RNA-binding protein NOB1 (sprot)

An RNA-binding protein NOB1 that is encoded in the genome of human.


KLK5_HUMAN Kallikrein-5 (sprot)

A kallikrein-5 that is encoded in the genome of human.


CEL2A_HUMAN Chymotrypsin-like elastase family member 2A (sprot)

A chymotrypsin-like elastase family member 2A that is encoded in the genome of human.


PMGE_HUMAN Bisphosphoglycerate mutase (sprot)

A bisphosphoglycerate mutase that is encoded in the genome of human.


ADPGK_HUMAN ADP-dependent glucokinase (sprot)

An ADP-dependent glucokinase that is encoded in the genome of human.


GDE_HUMAN Glycogen debranching enzyme (sprot)

A glycogen debranching enzyme that is encoded in the genome of human.


GALT_HUMAN Galactose-1-phosphate uridylyltransferase (sprot)

A galactose-1-phosphate uridylyltransferase that is encoded in the genome of human.


CARME_HUMAN Carnosine N-methyltransferase (sprot)

A carnosine N-methyltransferase that is encoded in the genome of human.


HUTI_HUMAN Probable imidazolonepropionase (sprot)

A probable imidazolonepropionase that is encoded in the genome of human.


CRNS1_HUMAN Carnosine synthase 1 (sprot)

A carnosine synthase 1 that is encoded in the genome of human.


HNMT_HUMAN Histamine N-methyltransferase (sprot)

A histamine N-methyltransferase that is encoded in the genome of human.


HUTH_HUMAN Histidine ammonia-lyase (sprot)

A histidine ammonia-lyase that is encoded in the genome of human.


GALK1_HUMAN Galactokinase (sprot)

A galactokinase that is encoded in the genome of human.


GAMT_HUMAN Guanidinoacetate N-methyltransferase (sprot)

A guanidinoacetate N-methyltransferase that is encoded in the genome of human.


MDHC_HUMAN Malate dehydrogenase, cytoplasmic (sprot)

A malate dehydrogenase, cytoplasmic that is encoded in the genome of human.


KFA_HUMAN Kynurenine formamidase (sprot)

A kynurenine formamidase that is encoded in the genome of human.


KMO_HUMAN Kynurenine 3-monooxygenase (sprot)

A kynurenine 3-monooxygenase that is encoded in the genome of human.


DEOC_HUMAN Deoxyribose-phosphate aldolase (sprot)

A deoxyribose-phosphate aldolase that is encoded in the genome of human.


SHPK_HUMAN Sedoheptulokinase (sprot)

A sedoheptulokinase that is encoded in the genome of human.


RPIA_HUMAN Ribose-5-phosphate isomerase (sprot)

A ribose-5-phosphate isomerase that is encoded in the genome of human.


ACPH_HUMAN Acylamino-acid-releasing enzyme (sprot)

An acylamino-acid-releasing enzyme that is encoded in the genome of human.


UCKL1_HUMAN Uridine-cytidine kinase-like 1 (sprot)

A uridine-cytidine kinase-like 1 that is encoded in the genome of human.


ADA_HUMAN Adenosine deaminase (sprot)

An adenosine deaminase that is encoded in the genome of human.


5NT1B_HUMAN Cytosolic 5'-nucleotidase 1B (sprot)

A cytosolic 5'-nucleotidase 1B that is encoded in the genome of human.


DNPH1_HUMAN 2'-deoxynucleoside 5'-phosphate N-hydrolase 1 (sprot)

A 2'-deoxynucleoside 5'-phosphate N-hydrolase 1 that is encoded in the genome of human.


SAST_HUMAN S-acyl fatty acid synthase thioesterase, medium chain (sprot)

An S-acyl fatty acid synthase thioesterase, medium chain that is encoded in the genome of human.


AACS_HUMAN Acetoacetyl-CoA synthetase (sprot)

An acetoacetyl-CoA synthetase that is encoded in the genome of human.


RIDA_HUMAN 2-iminobutanoate/2-iminopropanoate deaminase (sprot)

A 2-iminobutanoate/2-iminopropanoate deaminase that is encoded in the genome of human.


ARAP1_HUMAN Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 (sprot)

An Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 that is encoded in the genome of human.


CSN4_HUMAN COP9 signalosome complex subunit 4 (sprot)

A COP9 signalosome complex subunit 4 that is encoded in the genome of human.


DOCK7_HUMAN Dedicator of cytokinesis protein 7 (sprot)

A dedicator of cytokinesis protein 7 that is encoded in the genome of human.


EFMT2_HUMAN EEF1A lysine methyltransferase 2 (sprot)

An EEF1A lysine methyltransferase 2 that is encoded in the genome of human.


MT21D_HUMAN Protein N-lysine methyltransferase METTL21D (sprot)

A protein N-lysine methyltransferase METTL21D that is encoded in the genome of human.


EFMT1_HUMAN EEF1A lysine methyltransferase 1 (sprot)

An EEF1A lysine methyltransferase 1 that is encoded in the genome of human.


EF2KT_HUMAN Protein-lysine N-methyltransferase EEF2KMT (sprot)

A protein-lysine N-methyltransferase EEF2KMT that is encoded in the genome of human.


MAP kinase-activating death domain protein isoform h3 (human)

A MAP kinase-activating death domain protein (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q8WXG6-3.


MECOM_HUMAN Histone-lysine N-methyltransferase MECOM (sprot)

A histone-lysine N-methyltransferase MECOM that is encoded in the genome of human.


FRK_HUMAN Tyrosine-protein kinase FRK (sprot)

A tyrosine-protein kinase FRK that is encoded in the genome of human.


PREX2_HUMAN Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 protein (sprot)

A phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 protein that is encoded in the genome of human.


TTL_HUMAN Tubulin--tyrosine ligase (sprot)

A tubulin--tyrosine ligase that is encoded in the genome of human.


LPP60_HUMAN 60 kDa lysophospholipase (sprot)

A 60 kDa lysophospholipase that is encoded in the genome of human.


MYO9B_HUMAN Unconventional myosin-IXb (sprot)

A myosin-IXb that is encoded in the genome of human.


PDE12_HUMAN 2',5'-phosphodiesterase 12 (sprot)

A 2',5'-phosphodiesterase 12 that is encoded in the genome of human.


RBX2_HUMAN RING-box protein 2 (sprot)

A RING-box protein 2 that is encoded in the genome of human.


CUL9_HUMAN Cullin-9 (sprot)

A cullin-9 that is encoded in the genome of human.


RHOD_HUMAN Rho-related GTP-binding protein RhoD (sprot)

A Rho-related GTP-binding protein RhoD that is encoded in the genome of human.


WWP2_HUMAN NEDD4-like E3 ubiquitin-protein ligase WWP2 (sprot)

A NEDD4-like E3 ubiquitin-protein ligase WWP2 that is encoded in the genome of human.


LOX15_HUMAN Polyunsaturated fatty acid lipoxygenase ALOX15 (sprot)

A polyunsaturated fatty acid lipoxygenase ALOX15 that is encoded in the genome of human.


LOX5_HUMAN Polyunsaturated fatty acid 5-lipoxygenase (sprot)

A polyunsaturated fatty acid 5-lipoxygenase that is encoded in the genome of human.


phospholipid hydroperoxide glutathione peroxidase isoform Cytoplasmic (human)

A phospholipid hydroperoxide glutathione peroxidase isoform Cytoplasmic that is encoded in the genome of human.


DOCK3_HUMAN Dedicator of cytokinesis protein 3 (sprot)

A dedicator of cytokinesis protein 3 that is encoded in the genome of human.


RN216_HUMAN E3 ubiquitin-protein ligase RNF216 (sprot)

An E3 ubiquitin-protein ligase RNF216 that is encoded in the genome of human.


MOC2B_HUMAN Molybdopterin synthase catalytic subunit (sprot)

A molybdopterin synthase catalytic subunit that is encoded in the genome of human.


MOCOS_HUMAN Molybdenum cofactor sulfurase (sprot)

A molybdenum cofactor sulfurase that is encoded in the genome of human.


PPM1F_HUMAN Protein phosphatase 1F (sprot)

A protein phosphatase 1F that is encoded in the genome of human.


U17L2_HUMAN Ubiquitin carboxyl-terminal hydrolase 17 (sprot)

A ubiquitin carboxyl-terminal hydrolase 17 that is encoded in the genome of human.


CHAC1_HUMAN Glutathione-specific gamma-glutamylcyclotransferase 1 (sprot)

A glutathione-specific gamma-glutamylcyclotransferase 1 that is encoded in the genome of human.


SPAST_HUMAN Spastin (sprot)

A spastin that is encoded in the genome of human.


HCK_HUMAN Tyrosine-protein kinase HCK (sprot)

A tyrosine-protein kinase HCK that is encoded in the genome of human.


SHIP2_HUMAN Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 (sprot)

A phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 that is encoded in the genome of human.


EST1A_HUMAN Telomerase-binding protein EST1A (sprot)

A telomerase-binding protein EST1A that is encoded in the genome of human.


SMG1_HUMAN Serine/threonine-protein kinase SMG1 (sprot)

A serine/threonine-protein kinase SMG1 that is encoded in the genome of human.


TASP1_HUMAN Threonine aspartase 1 (sprot)

A threonine aspartase 1 that is encoded in the genome of human.


SRXN1_HUMAN Sulfiredoxin-1 (sprot)

A sulfiredoxin-1 that is encoded in the genome of human.


RGAP1_HUMAN Rac GTPase-activating protein 1 (sprot)

A Rac GTPase-activating protein 1 that is encoded in the genome of human.


ITPK1_HUMAN Inositol-tetrakisphosphate 1-kinase (sprot)

An inositol-tetrakisphosphate 1-kinase that is encoded in the genome of human.


PKHG3_HUMAN Pleckstrin homology domain-containing family G member 3 (sprot)

A pleckstrin homology domain-containing family G member 3 that is encoded in the genome of human.


U17L3_HUMAN Ubiquitin carboxyl-terminal hydrolase 17-like protein 3 (sprot)

A ubiquitin carboxyl-terminal hydrolase 17-like protein 3 that is encoded in the genome of human.


U17L4_HUMAN Inactive ubiquitin carboxyl-terminal hydrolase 17-like protein 4 (sprot)

An inactive ubiquitin carboxyl-terminal hydrolase 17-like protein 4 that is encoded in the genome of human.


RHG42_HUMAN Rho GTPase-activating protein 42 (sprot)

A Rho GTPase-activating protein 42 that is encoded in the genome of human.


TTL13_HUMAN Tubulin polyglutamylase TTLL13 (sprot)

A tubulin polyglutamylase Ttll13 that is encoded in the genome of human.


ENO4_HUMAN Enolase 4 (sprot)

An enolase 4 that is encoded in the genome of human.


TTLL8_HUMAN Protein monoglycylase TTLL8 (sprot)

A protein monoglycylase TTLL8 that is encoded in the genome of human.


RHG32_HUMAN Rho GTPase-activating protein 32 (sprot)

A rho/Cdc42/Rac GTPase-activating protein RICS that is encoded in the genome of human.


U17L5_HUMAN Ubiquitin carboxyl-terminal hydrolase 17-like protein 5 (sprot)

A ubiquitin carboxyl-terminal hydrolase 17-like protein 5 that is encoded in the genome of human.


MYO9A_HUMAN Unconventional myosin-IXa (sprot)

A myosin-IXa that is encoded in the genome of human.


U17LF_HUMAN Ubiquitin carboxyl-terminal hydrolase 17-like protein 15 (sprot)

A protein that is a translation product of the USP17L15 gene in human.


U17LA_HUMAN Ubiquitin carboxyl-terminal hydrolase 17-like protein 10 (sprot)

A protein that is a translation product of the USP17L10 gene in human.


U17LD_HUMAN Ubiquitin carboxyl-terminal hydrolase 17-like protein 13 (sprot)

A protein that is a translation product of the USP17L13 gene in human.


UL17C_HUMAN Ubiquitin carboxyl-terminal hydrolase 17-like protein 12 (sprot)

A protein that is a translation product of the USP17L12 gene in human.


U17LB_HUMAN Ubiquitin carboxyl-terminal hydrolase 17-like protein 11 (sprot)

A protein that is a translation product of the USP17L11 gene in human.


U17LL_HUMAN Ubiquitin carboxyl-terminal hydrolase 17-like protein 21 (sprot)

A protein that is a translation product of the USP17L21 gene in human.


U17LI_HUMAN Ubiquitin carboxyl-terminal hydrolase 17-like protein 18 (sprot)

A protein that is a translation product of the USP17L18 gene in human.


U17LM_HUMAN Ubiquitin carboxyl-terminal hydrolase 17-like protein 22 (sprot)

A protein that is a translation product of the USP17L22 gene in human.


U17LH_HUMAN Ubiquitin carboxyl-terminal hydrolase 17-like protein 17 (sprot)

A protein that is a translation product of the USP17L17 gene in human.


U17LJ_HUMAN Ubiquitin carboxyl-terminal hydrolase 17-like protein 19 (sprot)

A protein that is a translation product of the USP17L19 gene in human.


U17LK_HUMAN Ubiquitin carboxyl-terminal hydrolase 17-like protein 20 (sprot)

A protein that is a translation product of the USP17L20 gene in human.


PDE2A_HUMAN cGMP-dependent 3',5'-cyclic phosphodiesterase (sprot)

A cGMP-dependent 3',5'-cyclic phosphodiesterase that is encoded in the genome of human.


P85B_HUMAN Phosphatidylinositol 3-kinase regulatory subunit beta (sprot)

A phosphatidylinositol 3-kinase regulatory subunit beta that is encoded in the genome of human.


PITM1_HUMAN Membrane-associated phosphatidylinositol transfer protein 1 (sprot)

A membrane-associated phosphatidylinositol transfer protein 1 that is encoded in the genome of human.


RHG33_HUMAN Rho GTPase-activating protein 33 (sprot)

A Rho GTPase-activating protein 33 that is encoded in the genome of human.


SYNJ2_HUMAN Synaptojanin-2 (sprot)

A synaptojanin-2 that is encoded in the genome of human.


PMM2_HUMAN Phosphomannomutase 2 (sprot)

A phosphomannomutase 2 that is encoded in the genome of human.


INP4B_HUMAN Inositol polyphosphate 4-phosphatase type II (sprot)

An inositol polyphosphate 4-phosphatase type II that is encoded in the genome of human.


RHG06_HUMAN Rho GTPase-activating protein 6 (sprot)

A Rho GTPase-activating protein 6 that is encoded in the genome of human.


SRGP3_HUMAN SLIT-ROBO Rho GTPase-activating protein 3 (sprot)

A SLIT-ROBO Rho GTPase-activating protein 3 that is encoded in the genome of human.


VIP2_HUMAN Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 (sprot)

An inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 that is encoded in the genome of human.


SYNJ1_HUMAN Synaptojanin-1 (sprot)

A synaptojanin-1 that is encoded in the genome of human.


AK1BA_HUMAN Aldo-keto reductase family 1 member B10 (sprot)

An aldo-keto reductase family 1 member B10 that is encoded in the genome of human.


KIF5C_HUMAN Kinesin heavy chain isoform 5C (sprot)

A kinesin heavy chain isoform 5C that is encoded in the genome of human.


NDK8_HUMAN Putative nucleoside diphosphate kinase (sprot)

A protein that is a translation product of the NME2P1 gene in human.


NMT2_HUMAN Glycylpeptide N-tetradecanoyltransferase 2 (sprot)

A glycylpeptide N-tetradecanoyltransferase 2 that is encoded in the genome of human.


PDE8A_HUMAN High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A (sprot)

A high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A that is encoded in the genome of human.


DEN4B_HUMAN DENN domain-containing protein 4B (sprot)

A DENN domain-containing protein 4B that is encoded in the genome of human.


DNJB6_HUMAN DnaJ homolog subfamily B member 6 (sprot)

A DnaJ homolog subfamily B member 6 that is encoded in the genome of human.


P3C2G_HUMAN Phosphatidylinositol 3-kinase C2 domain-containing subunit gamma (sprot)

A phosphatidylinositol 3-kinase C2 domain-containing subunit gamma that is encoded in the genome of human.


PDE5A_HUMAN cGMP-specific 3',5'-cyclic phosphodiesterase (sprot)

A cGMP-specific 3',5'-cyclic phosphodiesterase that is encoded in the genome of human.


PDE9A_HUMAN High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (sprot)

A high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A that is encoded in the genome of human.


KPCD3_HUMAN Serine/threonine-protein kinase D3 (sprot)

A serine/threonine-protein kinase D3 that is encoded in the genome of human.


GFPT2_HUMAN Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 2 (sprot)

A glutamine--fructose-6-phosphate aminotransferase [isomerizing] 2 that is encoded in the genome of human.


FA13A_HUMAN Protein FAM13A (sprot)

A protein FAM13A that is encoded in the genome of human.


PDE8B_HUMAN High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B (sprot)

A high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B that is encoded in the genome of human.


GRP1_HUMAN RAS guanyl-releasing protein 1 (sprot)

A RAS guanyl-releasing protein 1 that is encoded in the genome of human.


TNKS1_HUMAN Poly [ADP-ribose] polymerase tankyrase-1 (sprot)

A poly [ADP-ribose] polymerase tankyrase-1 that is encoded in the genome of human.


TFIP8_HUMAN Tumor necrosis factor alpha-induced protein 8 (sprot)

A tumor necrosis factor alpha-induced protein 8 that is encoded in the genome of human.


BAG2_HUMAN BAG family molecular chaperone regulator 2 (sprot)

A BAG family molecular chaperone regulator 2 that is encoded in the genome of human.


BAG3_HUMAN BAG family molecular chaperone regulator 3 (sprot)

A BAG family molecular chaperone regulator 3 that is encoded in the genome of human.


PGK1_HUMAN Phosphoglycerate kinase 1 (sprot)

A phosphoglycerate kinase 1 that is encoded in the genome of human.


KAD1_HUMAN Adenylate kinase isoenzyme 1 (sprot)

An adenylate kinase isoenzyme 1 that is encoded in the genome of human.


ENOA_HUMAN Alpha-enolase (sprot)

An alpha-enolase that is encoded in the genome of human.


PGK2_HUMAN Phosphoglycerate kinase 2 (sprot)

A phosphoglycerate kinase 2 that is encoded in the genome of human.


ENOG_HUMAN Gamma-enolase (sprot)

A gamma-enolase that is encoded in the genome of human.


U17L8_HUMAN Inactive ubiquitin carboxyl-terminal hydrolase 17-like protein 8 (sprot)

An inactive ubiquitin carboxyl-terminal hydrolase 17-like protein 8 that is encoded in the genome of human.


HS71B_HUMAN Heat shock 70 kDa protein 1B (sprot)

A heat shock 70 kDa protein 1B that is encoded in the genome of human.


MYH3_HUMAN Myosin-3 (sprot)

A myosin-3 that is encoded in the genome of human.


MYH6_HUMAN Myosin-6 (sprot)

A myosin-6 that is encoded in the genome of human.


MYH8_HUMAN Myosin-8 (sprot)

A myosin-8 that is encoded in the genome of human.


ENOB_HUMAN Beta-enolase (sprot)

A beta-enolase that is encoded in the genome of human.


PGAM2_HUMAN Phosphoglycerate mutase 2 (sprot)

A phosphoglycerate mutase 2 that is encoded in the genome of human.


CHIN_HUMAN N-chimaerin (sprot)

An N-chimaerin that is encoded in the genome of human.


AK1C4_HUMAN Aldo-keto reductase family 1 member C4 (sprot)

An aldo-keto reductase family 1 member C4 that is encoded in the genome of human.


PTN2_HUMAN Tyrosine-protein phosphatase non-receptor type 2 (sprot)

A tyrosine-protein phosphatase non-receptor type 2 that is encoded in the genome of human.


PGAM1_HUMAN Phosphoglycerate mutase 1 (sprot)

A phosphoglycerate mutase 1 that is encoded in the genome of human.


BLVRB_HUMAN Flavin reductase (NADPH) (sprot)

A flavin reductase that is encoded in the genome of human.


GLPK_HUMAN Glycerol kinase (sprot)

A glycerol kinase that is encoded in the genome of human.


KINH_HUMAN Kinesin-1 heavy chain (sprot)

A kinesin-1 heavy chain that is encoded in the genome of human.


HS71L_HUMAN Heat shock 70 kDa protein 1-like (sprot)

A heat shock 70 kDa protein 1-like that is encoded in the genome of human.


NOS2_HUMAN Nitric oxide synthase, inducible (sprot)

A nitric oxide synthase, inducible that is encoded in the genome of human.


ARBK2_HUMAN Beta-adrenergic receptor kinase 2 (sprot)

A beta-adrenergic receptor kinase 2 that is encoded in the genome of human.


GPX4_HUMAN Phospholipid hydroperoxide glutathione peroxidase (sprot)

A phospholipid hydroperoxide glutathione peroxidase that is encoded in the genome of human.


RHG25_HUMAN Rho GTPase-activating protein 25 (sprot)

A Rho GTPase-activating protein 25 that is encoded in the genome of human.


PI4KA_HUMAN Phosphatidylinositol 4-kinase alpha (sprot)

A phosphatidylinositol 4-kinase alpha that is encoded in the genome of human.


RPGP1_HUMAN Rap1 GTPase-activating protein 1 (sprot)

A Rap1 GTPase-activating protein 1 that is encoded in the genome of human.


CHIO_HUMAN Beta-chimaerin (sprot)

A beta-chimaerin that is encoded in the genome of human.


AK1C2_HUMAN Aldo-keto reductase family 1 member C2 (sprot)

An aldo-keto reductase family 1 member C2 that is encoded in the genome of human.


PLAT3_HUMAN Phospholipase A and acyltransferase 3 (sprot)

A phospholipase A and acyltransferase 3 that is encoded in the genome of human.


PDE1A_HUMAN Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A (sprot)

A dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A that is encoded in the genome of human.


PP2AB_HUMAN Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform (sprot)

A serine/threonine-protein phosphatase 2A catalytic subunit beta isoform that is encoded in the genome of human.


PP2AA_HUMAN Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform (sprot)

A serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform that is encoded in the genome of human.


DEN2B_HUMAN DENN domain-containing protein 2B (sprot)

A DENN domain-containing protein 2B that is encoded in the genome of human.


RHG08_HUMAN Rho GTPase-activating protein 8 (sprot)

A Rho GTPase-activating protein 8 that is encoded in the genome of human.


RHG04_HUMAN Rho GTPase-activating protein 4 (sprot)

A Rho GTPase-activating protein 4 that is encoded in the genome of human.


PDE1B_HUMAN Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B (sprot)

A dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B that is encoded in the genome of human.


OCRL_HUMAN Inositol polyphosphate 5-phosphatase OCRL (sprot)

An inositol polyphosphate 5-phosphatase OCRL that is encoded in the genome of human.


KPCE_HUMAN Protein kinase C epsilon type (sprot)

A protein kinase C epsilon that is encoded in the genome of human.


AK1C1_HUMAN Aldo-keto reductase family 1 member C1 (sprot)

An aldo-keto reductase family 1 member C1 that is encoded in the genome of human.


EF1A2_HUMAN Elongation factor 1-alpha 2 (sprot)

An elongation factor 1-alpha 2 that is encoded in the genome of human.


RHG01_HUMAN Rho GTPase-activating protein 1 (sprot)

A Rho GTPase-activating protein 1 that is encoded in the genome of human.


PDE4C_HUMAN cAMP-specific 3',5'-cyclic phosphodiesterase 4C (sprot)

A cAMP-specific 3',5'-cyclic phosphodiesterase 4C that is encoded in the genome of human.


PDE4D_HUMAN cAMP-specific 3',5'-cyclic phosphodiesterase 4D (sprot)

A cAMP-specific 3',5'-cyclic phosphodiesterase 4D that is encoded in the genome of human.


U17LO_HUMAN Ubiquitin carboxyl-terminal hydrolase 17-like protein 24 (sprot)

A ubiquitin carboxyl-terminal hydrolase 17-like protein 24 that is encoded in the genome of human.


KIF5A_HUMAN Kinesin heavy chain isoform 5A (sprot)

A kinesin heavy chain isoform 5A that is encoded in the genome of human.


RHG05_HUMAN Rho GTPase-activating protein 5 (sprot)

A Rho GTPase-activating protein 5 that is encoded in the genome of human.


DUS8_HUMAN Dual specificity protein phosphatase 8 (sprot)

A dual specificity protein phosphatase 8 that is encoded in the genome of human.


MTMR1_HUMAN Myotubularin-related protein 1 (sprot)

A myotubularin-related protein 1 that is encoded in the genome of human.


MTMR3_HUMAN Myotubularin-related protein 3 (sprot)

A myotubularin-related protein 3 that is encoded in the genome of human.


RIN1_HUMAN Ras and Rab interactor 1 (sprot)

A Ras and Rab interactor 1 that is encoded in the genome of human.


PDE7A_HUMAN High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A (sprot)

A high affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A that is encoded in the genome of human.


TTL12_HUMAN Tubulin--tyrosine ligase-like protein 12 (sprot)

A tubulin--tyrosine ligase-like protein 12 that is encoded in the genome of human.


GNA13_HUMAN Guanine nucleotide-binding protein subunit alpha-13 (sprot)

A guanine nucleotide-binding protein subunit alpha-13 that is encoded in the genome of human.


GLPK3_HUMAN Glycerol kinase 3 (sprot)

A glycerol kinase 3 that is encoded in the genome of human.


GLPK2_HUMAN Glycerol kinase 2 (sprot)

A glycerol kinase 2 that is encoded in the genome of human.


TTLL4_HUMAN Tubulin monoglutamylase TTLL4 (sprot)

A tubulin monoglutamylase TTLL4 that is encoded in the genome of human.


GNMT_HUMAN Glycine N-methyltransferase (sprot)

A glycine N-methyltransferase that is encoded in the genome of human.


GAPD1_HUMAN GTPase-activating protein and VPS9 domain-containing protein 1 (sprot)

A GTPase-activating protein and VPS9 domain-containing protein 1 that is encoded in the genome of human.


RHG19_HUMAN Rho GTPase-activating protein 19 (sprot)

A Rho GTPase-activating protein 19 that is encoded in the genome of human.


JOS1_HUMAN Josephin-1 (sprot)

A josephin-1 that is encoded in the genome of human.


KPCD1_HUMAN Serine/threonine-protein kinase D1 (sprot)

A serine/threonine-protein kinase D1 that is encoded in the genome of human.


RBP1_HUMAN RalA-binding protein 1 (sprot)

A RalA-binding protein 1 that is encoded in the genome of human.


PI5PA_HUMAN Phosphatidylinositol 4,5-bisphosphate 5-phosphatase A (sprot)

A phosphatidylinositol 4,5-bisphosphate 5-phosphatase A that is encoded in the genome of human.


DUS6_HUMAN Dual specificity protein phosphatase 6 (sprot)

A dual specificity protein phosphatase 6 that is encoded in the genome of human.


DUS7_HUMAN Dual specificity protein phosphatase 7 (sprot)

A dual specificity protein phosphatase 7 that is encoded in the genome of human.


RHG44_HUMAN Rho GTPase-activating protein 44 (sprot)

A Rho GTPase-activating protein 44 that is encoded in the genome of human.


RHG31_HUMAN Rho GTPase-activating protein 31 (sprot)

A Rho GTPase-activating protein 31 that is encoded in the genome of human.


PARP6_HUMAN Protein mono-ADP-ribosyltransferase PARP6 (sprot)

A protein mono-ADP-ribosyltransferase PARP6 that is encoded in the genome of human.


PKHG6_HUMAN Pleckstrin homology domain-containing family G member 6 (sprot)

A pleckstrin homology domain-containing family G member 6 that is encoded in the genome of human.


RHGBB_HUMAN Inactive Rho GTPase-activating protein 11B (sprot)

A Rho GTPase-activating protein 11B that is encoded in the genome of human.


putative ubiquitin carboxyl-terminal hydrolase 41 (human)

A putative ubiquitin carboxyl-terminal hydrolase 41 that is encoded in the genome of human.


PA24E_HUMAN Cytosolic phospholipase A2 epsilon (sprot)

A cytosolic phospholipase A2 epsilon that is encoded in the genome of human.


TTLL9_HUMAN Probable tubulin polyglutamylase TTLL9 (sprot)

A probable tubulin polyglutamylase TTLL9 that is encoded in the genome of human.


PAR14_HUMAN Protein mono-ADP-ribosyltransferase PARP14 (sprot)

A protein mono-ADP-ribosyltransferase PARP14 that is encoded in the genome of human.


RHG29_HUMAN Rho GTPase-activating protein 29 (sprot)

A Rho GTPase-activating protein 29 that is encoded in the genome of human.


PAR10_HUMAN Protein mono-ADP-ribosyltransferase PARP10 (sprot)

A protein mono-ADP-ribosyltransferase PARP10 that is encoded in the genome of human.


RHG15_HUMAN Rho GTPase-activating protein 15 (sprot)

A Rho GTPase-activating protein 15 that is encoded in the genome of human.


PKHG4_HUMAN Puratrophin-1 (sprot)

A puratrophin-1 that is encoded in the genome of human.


ACBG2_HUMAN Long-chain-fatty-acid--CoA ligase ACSBG2 (sprot)

A long-chain-fatty-acid--CoA ligase ACSBG2 that is encoded in the genome of human.


TP8L3_HUMAN Tumor necrosis factor alpha-induced protein 8-like protein 3 (sprot)

A tumor necrosis factor alpha-induced protein 8-like protein 3 that is encoded in the genome of human.


DOC11_HUMAN Dedicator of cytokinesis protein 11 (sprot)

A dedicator of cytokinesis protein 11 that is encoded in the genome of human.


RHG21_HUMAN Rho GTPase-activating protein 21 (sprot)

A Rho GTPase-activating protein 21 that is encoded in the genome of human.


TUT4_HUMAN Terminal uridylyltransferase 4 (sprot)

A terminal uridylyltransferase 4 that is encoded in the genome of human.


KAD9_HUMAN Adenylate kinase 9 (sprot)

An adenylate kinase 9 that is encoded in the genome of human.


RHG40_HUMAN Rho GTPase-activating protein 40 (sprot)

A Rho GTPase-activating protein 40 that is encoded in the genome of human.


CBPC2_HUMAN Cytosolic carboxypeptidase 2 (sprot)

A cytosolic carboxypeptidase 2 that is encoded in the genome of human.


AB17B_HUMAN Alpha/beta hydrolase domain-containing protein 17B (sprot)

An alpha/beta hydrolase domain-containing protein 17B that is encoded in the genome of human.


SYDE2_HUMAN Rho GTPase-activating protein SYDE2 (sprot)

A Rho GTPase-activating protein SYDE2 that is encoded in the genome of human.


EF1A3_HUMAN Putative elongation factor 1-alpha-like 3 (sprot)

A protein that is a translation product of the EEF1A1P5 gene in human.


CBPC6_HUMAN Cytosolic carboxypeptidase 6 (sprot)

A cytosolic carboxypeptidase 6 that is encoded in the genome of human.


OTUD1_HUMAN OTU domain-containing protein 1 (sprot)

An OTU domain-containing protein 1 that is encoded in the genome of human.


TUT7_HUMAN Terminal uridylyltransferase 7 (sprot)

A terminal uridylyltransferase 7 that is encoded in the genome of human.


DEN4C_HUMAN DENN domain-containing protein 4C (sprot)

A DENN domain-containing protein 4C that is encoded in the genome of human.


DEN2C_HUMAN DENN domain-containing protein 2C (sprot)

A DENN domain-containing protein 2C that is encoded in the genome of human.


PA24F_HUMAN Cytosolic phospholipase A2 zeta (sprot)

A cytosolic phospholipase A2 zeta that is encoded in the genome of human.


RHG17_HUMAN Rho GTPase-activating protein 17 (sprot)

A Rho GTPase-activating protein 17 that is encoded in the genome of human.


TTLL5_HUMAN Tubulin polyglutamylase TTLL5 (sprot)

A tubulin polyglutamylase TTLL5 that is encoded in the genome of human.


DEN5A_HUMAN DENN domain-containing protein 5A (sprot)

A DENN domain-containing protein 5A that is encoded in the genome of human.


PLBL1_HUMAN Phospholipase B-like 1 (sprot)

A phospholipase B-like 1 that is encoded in the genome of human.


RHGBA_HUMAN Rho GTPase-activating protein 11A (sprot)

A Rho GTPase-activating protein 11A that is encoded in the genome of human.


TP8L2_HUMAN Tumor necrosis factor alpha-induced protein 8-like protein 2 (sprot)

A tumor necrosis factor alpha-induced protein 8-like protein 2 that is encoded in the genome of human.


AB17C_HUMAN Alpha/beta hydrolase domain-containing protein 17C (sprot)

An alpha/beta hydrolase domain-containing protein 17C that is encoded in the genome of human.


VIP1_HUMAN Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 (sprot)

An inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 that is encoded in the genome of human.


DNMBP_HUMAN Dynamin-binding protein (sprot)

A dynamin-binding protein that is encoded in the genome of human.


FGD5_HUMAN FYVE, RhoGEF and PH domain-containing protein 5 (sprot)

A FYVE, RhoGEF and PH domain-containing protein 5 that is encoded in the genome of human.


RINL_HUMAN Ras and Rab interactor-like protein (sprot)

A Ras and Rab interactor-like protein that is encoded in the genome of human.


TTLL7_HUMAN Tubulin polyglutamylase TTLL7 (sprot)

A tubulin polyglutamylase TTLL7 that is encoded in the genome of human.


RHG27_HUMAN Rho GTPase-activating protein 27 (sprot)

A Rho GTPase-activating protein 27 that is encoded in the genome of human.


DEN5B_HUMAN DENN domain-containing protein 5B (sprot)

A DENN domain-containing protein 5B that is encoded in the genome of human.


TTL10_HUMAN Inactive polyglycylase TTLL10 (sprot)

A protein polyglycylase TTLL10 that is encoded in the genome of human.


SYDE1_HUMAN Rho GTPase-activating protein SYDE1 (sprot)

A Rho GTPase-activating protein SYDE1 that is encoded in the genome of human.


U17L1_HUMAN Ubiquitin carboxyl-terminal hydrolase 17-like protein 1 (sprot)

A protein that is a translation product of the USP17L1 gene in human.


MYCPP_HUMAN C-myc promoter-binding protein (sprot)

A C-myc promoter-binding protein that is encoded in the genome of human.


SRGP1_HUMAN SLIT-ROBO Rho GTPase-activating protein 1 (sprot)

A SLIT-ROBO Rho GTPase-activating protein 1 that is encoded in the genome of human.


RHG30_HUMAN Rho GTPase-activating protein 30 (sprot)

A Rho GTPase-activating protein 30 that is encoded in the genome of human.


ATG4D_HUMAN Cysteine protease ATG4D (sprot)

A cysteine protease ATG4D that is encoded in the genome of human.


ACOT1_HUMAN Acyl-coenzyme A thioesterase 1 (sprot)

An acyl-coenzyme A thioesterase 1 that is encoded in the genome of human.


ARHGP_HUMAN Rho guanine nucleotide exchange factor 25 (sprot)

A Rho guanine nucleotide exchange factor 25 that is encoded in the genome of human.


MTMRD_HUMAN Myotubularin-related protein 13 (sprot)

A myotubularin-related protein 13 that is encoded in the genome of human.


PA24D_HUMAN Cytosolic phospholipase A2 delta (sprot)

A cytosolic phospholipase A2 delta that is encoded in the genome of human.


DEN1C_HUMAN DENN domain-containing protein 1C (sprot)

A DENN domain-containing protein 1C that is encoded in the genome of human.


DEN6A_HUMAN Protein DENND6A (sprot)

A protein FAM116A that is encoded in the genome of human.


RHG12_HUMAN Rho GTPase-activating protein 12 (sprot)

A Rho GTPase-activating protein 12 that is encoded in the genome of human.


MSRB3_HUMAN Methionine-R-sulfoxide reductase B3 (sprot)

A methionine-R-sulfoxide reductase B3, mitochondrial that is encoded in the genome of human.


RIMKA_HUMAN N-acetylaspartylglutamate synthase A (sprot)

An N-acetylaspartylglutamate synthase A that is encoded in the genome of human.


PARP9_HUMAN Protein mono-ADP-ribosyltransferase PARP9 (sprot)

A protein mono-ADP-ribosyltransferase PARP9 that is encoded in the genome of human.


TAGAP_HUMAN T-cell activation Rho GTPase-activating protein (sprot)

A T-cell activation Rho GTPase-activating protein that is encoded in the genome of human.


DOCK4_HUMAN Dedicator of cytokinesis protein 4 (sprot)

A dedicator of cytokinesis protein 4 that is encoded in the genome of human.


RHG24_HUMAN Rho GTPase-activating protein 24 (sprot)

A Rho GTPase-activating protein 24 that is encoded in the genome of human.


RHG18_HUMAN Rho GTPase-activating protein 18 (sprot)

A Rho GTPase-activating protein 18 that is encoded in the genome of human.


PARP8_HUMAN Protein mono-ADP-ribosyltransferase PARP8 (sprot)

A protein mono-ADP-ribosyltransferase PARP8 that is encoded in the genome of human.


TTLL6_HUMAN Tubulin polyglutamylase TTLL6 (sprot)

A tubulin polyglutamylase TTLL6 that is encoded in the genome of human.


RGF1A_HUMAN Ras-GEF domain-containing family member 1A (sprot)

A Ras-GEF domain-containing family member 1A that is encoded in the genome of human.


MTMRE_HUMAN Myotubularin-related protein 14 (sprot)

A myotubularin-related protein 14 that is encoded in the genome of human.


CBPC5_HUMAN Cytosolic carboxypeptidase-like protein 5 (sprot)

A cytosolic carboxypeptidase-like protein 5 that is encoded in the genome of human.


DEN6B_HUMAN Protein DENND6B (sprot)

A protein FAM116B that is encoded in the genome of human.


CBPC3_HUMAN Cytosolic carboxypeptidase 3 (sprot)

A cytosolic carboxypeptidase 3 that is encoded in the genome of human.


DOCK8_HUMAN Dedicator of cytokinesis protein 8 (sprot)

A dedicator of cytokinesis protein 8 that is encoded in the genome of human.


TTL11_HUMAN Tubulin polyglutamylase TTLL11 (sprot)

A tubulin polyglutamylase TTLL11 that is encoded in the genome of human.


JOS2_HUMAN Josephin-2 (sprot)

A josephin-2 that is encoded in the genome of human.


RIN3_HUMAN Ras and Rab interactor 3 (sprot)

A Ras and Rab interactor 3 that is encoded in the genome of human.


R3GEF_HUMAN Guanine nucleotide exchange factor for Rab-3A (sprot)

A guanine nucleotide exchange factor for Rab-3A that is encoded in the genome of human.


P4K2B_HUMAN Phosphatidylinositol 4-kinase type 2-beta (sprot)

A phosphatidylinositol 4-kinase type 2-beta that is encoded in the genome of human.


GRP4_HUMAN RAS guanyl-releasing protein 4 (sprot)

A RAS guanyl-releasing protein 4 that is encoded in the genome of human.


PANK1_HUMAN Pantothenate kinase 1 (sprot)

A pantothenate kinase 1 that is encoded in the genome of human.


CHAC2_HUMAN Glutathione-specific gamma-glutamylcyclotransferase 2 (sprot)

A glutathione-specific gamma-glutamylcyclotransferase 2 that is encoded in the genome of human.


DEP1B_HUMAN DEP domain-containing protein 1B (sprot)

A DEP domain-containing protein 1B that is encoded in the genome of human.


TP8L1_HUMAN Tumor necrosis factor alpha-induced protein 8-like protein 1 (sprot)

A tumor necrosis factor alpha-induced protein 8-like protein 1 that is encoded in the genome of human.


ARAP3_HUMAN Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 (sprot)

An Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 that is encoded in the genome of human.


ACO11_HUMAN Acyl-coenzyme A thioesterase 11 (sprot)

An acyl-coenzyme A thioesterase 11 that is encoded in the genome of human.


RIN2_HUMAN Ras and Rab interactor 2 (sprot)

A Ras and Rab interactor 2 that is encoded in the genome of human.


ARAP2_HUMAN Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2 (sprot)

An Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2 that is encoded in the genome of human.


STAR8_HUMAN StAR-related lipid transfer protein 8 (sprot)

A StAR-related lipid transfer protein 8 that is encoded in the genome of human.


IP6K1_HUMAN Inositol hexakisphosphate kinase 1 (sprot)

An inositol hexakisphosphate kinase 1 that is encoded in the genome of human.


HS105_HUMAN Heat shock protein 105 kDa (sprot)

A heat shock protein 105 kDa that is encoded in the genome of human.


DOCK2_HUMAN Dedicator of cytokinesis protein 2 (sprot)

A dedicator of cytokinesis protein 2 that is encoded in the genome of human.


HMHA1_HUMAN Rho GTPase-activating protein 45 (sprot)

A Rho GTPase-activating protein 45 that is encoded in the genome of human.


PMM1_HUMAN Phosphomannomutase 1 (sprot)

A phosphomannomutase 1 that is encoded in the genome of human.


DOC10_HUMAN Dedicator of cytokinesis protein 10 (sprot)

A dedicator of cytokinesis protein 10 that is encoded in the genome of human.


SIPA1_HUMAN Signal-induced proliferation-associated protein 1 (sprot)

A signal-induced proliferation-associated protein 1 that is encoded in the genome of human.


ACBG1_HUMAN Long-chain-fatty-acid--CoA ligase ACSBG1 (sprot)

A long-chain-fatty-acid--CoA ligase ACSBG1 that is encoded in the genome of human.


AB17A_HUMAN Alpha/beta hydrolase domain-containing protein 17A (sprot)

An alpha/beta hydrolase domain-containing protein 17A that is encoded in the genome of human.


DOCK6_HUMAN Dedicator of cytokinesis protein 6 (sprot)

A dedicator of cytokinesis protein 6 that is encoded in the genome of human.


GMPPA_HUMAN Mannose-1-phosphate guanyltransferase alpha (sprot)

A mannose-1-phosphate guanyltransferase alpha that is encoded in the genome of human.


PLAT5_HUMAN Phospholipase A and acyltransferase 5 (sprot)

A phospholipase A and acyltransferase 5 that is encoded in the genome of human.


CNO6L_HUMAN CCR4-NOT transcription complex subunit 6-like (sprot)

A CCR4-NOT transcription complex subunit 6-like that is encoded in the genome of human.


KAD7_HUMAN Adenylate kinase 7 (sprot)

An adenylate kinase 7 that is encoded in the genome of human.


KAD8_HUMAN Adenylate kinase 8 (sprot)

An adenylate kinase 8 that is encoded in the genome of human.


CBPC4_HUMAN Cytosolic carboxypeptidase 4 (sprot)

A cytosolic carboxypeptidase 4 that is encoded in the genome of human.


SPT13_HUMAN Spermatogenesis-associated protein 13 (sprot)

A spermatogenesis-associated protein 13 that is encoded in the genome of human.


ANR27_HUMAN Ankyrin repeat domain-containing protein 27 (sprot)

An ankyrin repeat domain-containing protein 27 that is encoded in the genome of human.


IP6K3_HUMAN Inositol hexakisphosphate kinase 3 (sprot)

An inositol hexakisphosphate kinase 3 that is encoded in the genome of human.


INP4A_HUMAN Inositol polyphosphate-4-phosphatase type I A (sprot)

An inositol polyphosphate-4-phosphatase type I A that is encoded in the genome of human.


PKH4B_HUMAN Pleckstrin homology domain-containing family G member 4B (sprot)

A pleckstrin homology domain-containing family G member 4B that is encoded in the genome of human.


ALS2_HUMAN Alsin (sprot)

An alsin that is encoded in the genome of human.


RHG07_HUMAN Rho GTPase-activating protein 7 (sprot)

A Rho GTPase-activating protein 7 that is encoded in the genome of human.


OSBL9_HUMAN Oxysterol-binding protein-related protein 9 (sprot)

An oxysterol-binding protein-related protein 9 that is encoded in the genome of human.


DNJC2_HUMAN DnaJ homolog subfamily C member 2 (sprot)

A DnaJ homolog subfamily C member 2 that is encoded in the genome of human.


DNJC7_HUMAN DnaJ homolog subfamily C member 7 (sprot)

A DnaJ homolog subfamily C member 7 that is encoded in the genome of human.


BAG1_HUMAN BAG family molecular chaperone regulator 1 (sprot)

A BAG family molecular chaperone regulator 1 that is encoded in the genome of human.


DUS9_HUMAN Dual specificity protein phosphatase 9 (sprot)

A dual specificity protein phosphatase 9 that is encoded in the genome of human.


RHG09_HUMAN Rho GTPase-activating protein 9 (sprot)

A Rho GTPase-activating protein 9 that is encoded in the genome of human.


INP5K_HUMAN Inositol polyphosphate 5-phosphatase K (sprot)

An inositol polyphosphate 5-phosphatase K that is encoded in the genome of human.


P4K2A_HUMAN Phosphatidylinositol 4-kinase type 2-alpha (sprot)

A phosphatidylinositol 4-kinase type 2-alpha that is encoded in the genome of human.


TTLL2_HUMAN Probable tubulin polyglutamylase TTLL2 (sprot)

A probable tubulin polyglutamylase TTLL2 that is encoded in the genome of human.


OSBL1_HUMAN Oxysterol-binding protein-related protein 1 (sprot)

An oxysterol-binding protein-related protein 1 that is encoded in the genome of human.


DUS16_HUMAN Dual specificity protein phosphatase 16 (sprot)

A dual specificity protein phosphatase 16 that is encoded in the genome of human.


DOCK9_HUMAN Dedicator of cytokinesis protein 9 (sprot)

A dedicator of cytokinesis protein 9 that is encoded in the genome of human.


PITM3_HUMAN Membrane-associated phosphatidylinositol transfer protein 3 (sprot)

A membrane-associated phosphatidylinositol transfer protein 3 that is encoded in the genome of human.


PITM2_HUMAN Membrane-associated phosphatidylinositol transfer protein 2 (sprot)

A membrane-associated phosphatidylinositol transfer protein 2 that is encoded in the genome of human.


OSBL7_HUMAN Oxysterol-binding protein-related protein 7 (sprot)

An oxysterol-binding protein-related protein 7 that is encoded in the genome of human.


OSBL6_HUMAN Oxysterol-binding protein-related protein 6 (sprot)

An oxysterol-binding protein-related protein 6 that is encoded in the genome of human.


KPCD2_HUMAN Serine/threonine-protein kinase D2 (sprot)

A serine/threonine-protein kinase D2 that is encoded in the genome of human.


PA2GF_HUMAN Group IIF secretory phospholipase A2 (sprot)

A group IIF secretory phospholipase A2 that is encoded in the genome of human.


OSBL2_HUMAN Oxysterol-binding protein-related protein 2 (sprot)

An oxysterol-binding protein-related protein 2 that is encoded in the genome of human.


TNKS2_HUMAN Poly [ADP-ribose] polymerase tankyrase-2 (sprot)

A poly [ADP-ribose] polymerase tankyrase-2 that is encoded in the genome of human.


ATX3L_HUMAN Ataxin-3-like protein (sprot)

A protein that is a translation product of the ATXN3L gene in human.


DEFI6_HUMAN Differentially expressed in FDCP 6 homolog (sprot)

A differentially expressed in FDCP 6 that is encoded in the genome of human.


OSBL3_HUMAN Oxysterol-binding protein-related protein 3 (sprot)

An oxysterol-binding protein-related protein 3 that is encoded in the genome of human.


DEN2D_HUMAN DENN domain-containing protein 2D (sprot)

A DENN domain-containing protein 2D that is encoded in the genome of human.


DOCK5_HUMAN Dedicator of cytokinesis protein 5 (sprot)

A dedicator of cytokinesis protein 5 that is encoded in the genome of human.


PGES2_HUMAN Prostaglandin E synthase 2 (sprot)

A prostaglandin E synthase 2 that is encoded in the genome of human.


PANK3_HUMAN Pantothenate kinase 3 (sprot)

A pantothenate kinase 3 that is encoded in the genome of human.


EKI1_HUMAN Ethanolamine kinase 1 (sprot)

An ethanolamine kinase 1 that is encoded in the genome of human.


PDE11_HUMAN Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A (sprot)

A dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A that is encoded in the genome of human.


PLAT1_HUMAN Phospholipase A and acyltransferase 1 (sprot)

An HRAS-like suppressor that is encoded in the genome of human.


PDE7B_HUMAN cAMP-specific 3',5'-cyclic phosphodiesterase 7B (sprot)

A cAMP-specific 3',5'-cyclic phosphodiesterase 7B that is encoded in the genome of human.


EKI2_HUMAN Ethanolamine kinase 2 (sprot)

An ethanolamine kinase 2 that is encoded in the genome of human.


PLAT2_HUMAN Phospholipase A and acyltransferase 2 (sprot)

A phospholipase A and acyltransferase 2 that is encoded in the genome of human.


FA13B_HUMAN Protein FAM13B (sprot)

A protein FAM13B that is encoded in the genome of human.


MSRB1_HUMAN Methionine-R-sulfoxide reductase B1 (sprot)

A methionine-R-sulfoxide reductase B1 that is encoded in the genome of human.


GMIP_HUMAN GEM-interacting protein (sprot)

A GEM-interacting protein that is encoded in the genome of human.


RHG23_HUMAN Rho GTPase-activating protein 23 (sprot)

A Rho GTPase-activating protein 23 that is encoded in the genome of human.


RHG20_HUMAN Rho GTPase-activating protein 20 (sprot)

A Rho GTPase-activating protein 20 that is encoded in the genome of human.


RHG28_HUMAN Rho GTPase-activating protein 28 (sprot)

A Rho GTPase-activating protein 28 that is encoded in the genome of human.


PPR1B_HUMAN Protein phosphatase 1 regulatory subunit 1B (sprot)

A protein phosphatase 1 regulatory subunit 1B that is encoded in the genome of human.


SWP70_HUMAN Switch-associated protein 70 (sprot)

A switch-associated protein 70 that is encoded in the genome of human.


UBP25_HUMAN Ubiquitin carboxyl-terminal hydrolase 25 (sprot)

A ubiquitin carboxyl-terminal hydrolase 25 that is encoded in the genome of human.


RABX5_HUMAN Rab5 GDP/GTP exchange factor (sprot)

A Rab5 GDP/GTP exchange factor that is encoded in the genome of human.


PARP4_HUMAN Protein mono-ADP-ribosyltransferase PARP4 (sprot)

A protein mono-ADP-ribosyltransferase PARP4 that is encoded in the genome of human.


BAG5_HUMAN BAG family molecular chaperone regulator 5 (sprot)

A BAG family molecular chaperone regulator 5 that is encoded in the genome of human.


PLAT4_HUMAN Phospholipase A and acyltransferase 4 (sprot)

A phospholipase A and acyltransferase 4 that is encoded in the genome of human.


DEN2A_HUMAN DENN domain-containing protein 2A (sprot)

A DENN domain-containing protein 2A that is encoded in the genome of human.


RIMKB_HUMAN Beta-citrylglutamate synthase B (sprot)

A beta-citrylglutamate synthase B that is encoded in the genome of human.


PKHG1_HUMAN Pleckstrin homology domain-containing family G member 1 (sprot)

A pleckstrin homology domain-containing family G member 1 that is encoded in the genome of human.


CNOT6_HUMAN CCR4-NOT transcription complex subunit 6 (sprot)

A CCR4-NOT transcription complex subunit 6 that is encoded in the genome of human.


RHG26_HUMAN Rho GTPase-activating protein 26 (sprot)

A Rho GTPase-activating protein 26 that is encoded in the genome of human.


CBPC1_HUMAN Cytosolic carboxypeptidase 1 (sprot)

A cytosolic carboxypeptidase 1 that is encoded in the genome of human.


DYN3_HUMAN Dynamin-3 (sprot)

A dynamin-3 that is encoded in the genome of human.


PDE10_HUMAN cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (sprot)

A cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A that is encoded in the genome of human.


MSRB2_HUMAN Methionine-R-sulfoxide reductase B2, mitochondrial (sprot)

A methionine-R-sulfoxide reductase B2, mitochondrial that is encoded in the genome of human.


3BP1_HUMAN SH3 domain-binding protein 1 (sprot)

An SH3 domain-binding protein 1 that is encoded in the genome of human.


STA13_HUMAN StAR-related lipid transfer protein 13 (sprot)

A StAR-related lipid transfer protein 13 that is encoded in the genome of human.


FARP1_HUMAN FERM, ARHGEF and pleckstrin domain-containing protein 1 (sprot)

A FERM, ARHGEF and pleckstrin domain-containing protein 1 that is encoded in the genome of human.


RPGF2_HUMAN Rap guanine nucleotide exchange factor 2 (sprot)

A Rap guanine nucleotide exchange factor 2 that is encoded in the genome of human.


TTLL3_HUMAN Tubulin monoglycylase TTLL3 (sprot)

A tubulin monoglycylase TTLL3 that is encoded in the genome of human.


GMPPB_HUMAN Mannose-1-phosphate guanyltransferase beta (sprot)

A mannose-1-phosphate guanyltransferase beta that is encoded in the genome of human.


DUS10_HUMAN Dual specificity protein phosphatase 10 (sprot)

A dual specificity protein phosphatase 10 that is encoded in the genome of human.


inflammatory response

biolink:BiologicalProcess biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:NamedThing biolink:Occurrent biolink:OntologyClass biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages.


miRNA-mediated post-transcriptional gene silencing

A post-transcriptional gene silencing pathway in which regulatory microRNAs (miRNAs) elicit silencing of specific target genes. miRNAs are endogenous 21-24 nucleotide small RNAs processed from stem-loop RNA precursors (pre-miRNAs). Once incorporated into a RNA-induced silencing complex (RISC), miRNAs can downregulate protein production by either of two posttranscriptional mechanisms: endonucleolytic cleavage of the RNA (often mRNA) or mRNA translational repression, usually accompanied by poly-A tail shortening and subsequent degradation of the mRNA. miRNAs are present in all the animals and in plants, whereas siRNAs are present in lower animals and in plants.


transcription initiation at RNA polymerase I promoter

A transcription initiation process that takes place at a RNA polymerase I gene promoter. Ribosomal RNAs (rRNA) genes are transcribed by RNA polymerase I.


negative regulation of MAP kinase activity

Any process that stops, prevents, or reduces the frequency, rate or extent of MAP kinase activity.


positive regulation of MAP kinase activity

Any process that activates or increases the frequency, rate or extent of MAP kinase activity.


regulation of ERK1 and ERK2 cascade

Any process that modulates the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade.


immature alpha-beta T cell

biolink:Cell biolink:AnatomicalEntity biolink:OrganismalEntity biolink:BiologicalEntity biolink:NamedThing biolink:PhysicalEssence biolink:SubjectOfInvestigation biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

An alpha-beta T cell that has an immature phenotype and has not completed T cell selection.


AMFR_HUMAN E3 ubiquitin-protein ligase AMFR (sprot)

An E3 ubiquitin-protein ligase AMFR that is encoded in the genome of human.


HLGB_STAA8 Gamma-hemolysin component B (sprot)

A protein that is a translation product of the hlgB gene in Staphylococcus aureus subsp. aureus NCTC 8325.


cellular response to muramyl dipeptide

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a muramyl dipeptide stimulus. Muramyl dipeptide is derived from peptidoglycan.


toll-like receptor TLR6:TLR2 signaling pathway

biolink:Pathway biolink:BiologicalProcess biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:NamedThing biolink:OntologyClass biolink:Occurrent biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

The series of molecular signals initiated by a ligand binding of a heterodimeric TLR6:TLR2 complex, followed by transmission of the signal by the activated receptor, and ending with the regulation of a downstream cellular process, e.g. transcription.


biolink:MolecularActivity biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:NamedThing biolink:Occurrent biolink:OntologyClass biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: peptide(out) + H+(out) = peptide(in) + H+(in), up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by hydrogen ion movement.


phagocytic vesicle membrane

biolink:CellularComponent biolink:AnatomicalEntity biolink:OrganismalEntity biolink:BiologicalEntity biolink:NamedThing biolink:PhysicalEssence biolink:SubjectOfInvestigation biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

The lipid bilayer surrounding a phagocytic vesicle.


S15A2_HUMAN Solute carrier family 15 member 2 (sprot)

A solute carrier family 15 member 2 that is encoded in the genome of human.


platelet aggregation

The adhesion of one platelet to one or more other platelets via adhesion molecules.


hematopoietic stem cell differentiation

The process in which a relatively unspecialized cell acquires specialized features of a hematopoietic stem cell. A stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells.


positive regulation of hematopoietic stem cell differentiation

Any process that activates or increases the frequency, rate or extent of hematopoietic stem cell differentiation.


positive regulation of intracellular signal transduction

Any process that activates or increases the frequency, rate or extent of intracellular signal transduction.


Notch binding

Binding to a Notch (N) protein, a surface receptor.


intracellular signal transduction

The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.


platelet

A non-nucleated disk-shaped cell formed by extrusion from megakaryocytes, found in the blood of all mammals, and mainly involved in blood coagulation.


lipopolysaccharide

Liposaccharide natural compounds consisting of a trisaccharide repeating unit (two heptose units and octulosonic acid) with oligosaccharide side chains and 3-hydroxytetradecanoic acid units (they are a major constituent of the cell walls of Gram-negative bacteria).


regulation of non-canonical NF-kappaB signal transduction

Any process that modulates the frequency, rate or extent of the non-canonical NF-kappaB signaling cascade.


CAV1_HUMAN Caveolin-1 (sprot)

A caveolin-1 that is encoded in the genome of human.


NLRP3 inflammasome complex assembly

The aggregation, arrangement and bonding together of a set of components to form the NLRP3 inflammasome complex, occurring at the level of an individual cell.


nucleotide-binding oligomerization domain containing 1 signaling pathway

The series of molecular signals initiated by the binding of a ligand (such as a bacterial peptidoglycan) to a cytoplasmic nucleotide-binding oligomerization domain containing 1 (NOD1) protein receptor, and ending with regulation of a downstream cellular process.


NLRP6 inflammasome complex assembly

The aggregation, arrangement and bonding together of a set of components to form a NLRP6 inflammasome complex.


NLRP1 inflammasome complex assembly

The aggregation, arrangement and bonding together of a set of components to form a NLRP1 inflammasome complex.


nucleotide-binding oligomerization domain containing 2 signaling pathway

The series of molecular signals initiated by the binding of a ligand (such as a bacterial peptidoglycan) to a cytoplasmic nucleotide-binding oligomerization domain containing 2 (NOD2) protein receptor, and ending with regulation of a downstream cellular process.


polarized epithelial cell differentiation

The process in which a relatively unspecialized cell acquires specialized features of a polarized epithelial cell. The polarized epithelial cell can be any of the cells within an epithelium where the epithelial sheet is oriented with respect to the planar axis.


chaperone-mediated autophagy

The autophagy process which begins when chaperones and co-chaperones recognize a target motif and unfold the substrate protein. The proteins are then transported to the lysosome where they are degraded.


positive regulation of Rac protein signal transduction

Any process that activates or increases the frequency, rate or extent of Rac protein signal transduction.


enzyme-linked receptor protein signaling pathway

The series of molecular signals initiated by an extracellular ligand binding to a receptor on the surface of the target cell, where the receptor possesses catalytic activity or is closely associated with an enzyme such as a protein kinase, and ending with the regulation of a downstream cellular process, e.g. transcription.


positive regulation of execution phase of apoptosis

Any process that activates or increases the frequency, rate or extent of execution phase of apoptosis.


extrinsic apoptotic signaling pathway via death domain receptors

The series of molecular signals in which a signal is conveyed from the cell surface to trigger the apoptotic death of a cell. The pathway starts with a ligand binding to a death domain receptor on the cell surface, and ends when the execution phase of apoptosis is triggered.


TLR2_HUMAN Toll-like receptor 2 (sprot)

A Toll-like receptor 2 that is encoded in the genome of human.


TLR6_HUMAN Toll-like receptor 6 (sprot)

A Toll-like receptor 6 that is encoded in the genome of human.


Toll-like receptor 2-Toll-like receptor 6 protein complex

A heterodimeric protein complex containing Toll-like receptor 2 (TLR2) and Toll-like receptor 6 (TLR6).


tumor necrosis factor receptor activity

Combining with tumor necrosis factor, a proinflammatory cytokine produced by monocytes and macrophages, to initiate a change in cell function.


negative regulation of tumor necrosis factor-mediated signaling pathway

Any process that decreases the rate or extent of the tumor necrosis factor-mediated signaling pathway. The tumor necrosis factor-mediated signaling pathway is the series of molecular signals generated as a consequence of tumor necrosis factor binding to a cell surface receptor.


transmembrane receptor protein tyrosine kinase activator activity

Binds to and increases the activity of a transmembrane receptor protein tyrosine kinase.


protein-glutamine glutaminase activity

Catalysis of the reaction: protein L-glutamine + H2O = protein L-glutamate + NH3.


Catalysis of the reaction: H2O + sphingomyelin = ceramide + choline phosphate + H+.


postsynaptic actin cytoskeleton organization

A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins in the postsynaptic actin cytoskeleton.


skeletal muscle acetylcholine-gated channel clustering

The accumulation of acetylcholine-gated cation channels in a narrow, central region of muscle fibers, in apposition to nerve terminals.


lipoteichoic acid immune receptor activity

Combining with lipoteichoic acid and transmitting the signal to initiate an innate immune response.


ceramide metabolic process

The chemical reactions and pathways involving ceramides, any N-acylated sphingoid.


cell cortex

The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins.


mitochondrial membrane

Either of the lipid bilayers that surround the mitochondrion and form the mitochondrial envelope.


neuromuscular junction

The junction between the axon of a motor neuron and a muscle fiber. In response to the arrival of action potentials, the presynaptic button releases molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane of the muscle fiber, leading to a change in post-synaptic potential.


ASC_HUMAN Apoptosis-associated speck-like protein containing a CARD (sprot)

An apoptosis-associated speck-like protein containing a CARD that is encoded in the genome of human.


receptor-interacting serine/threonine-protein kinase 2 isoform h1 (human)

A receptor-interacting serine/threonine-protein kinase 2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O43353-1.


CAPR1_HUMAN Caprin-1 (sprot)

A caprin-1 that is encoded in the genome of human.


SCRIB_HUMAN Protein scribble homolog (sprot)

A protein LAP4 that is encoded in the genome of human.


lysosome-associated membrane glycoprotein 2 isoform hLAMP-2A (human)

A lysosome-associated membrane glycoprotein 2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P13473-1.


ZNRF4_HUMAN E3 ubiquitin-protein ligase ZNRF4 (sprot)

An E3 ubiquitin-protein ligase ZNRF4 that is encoded in the genome of human.


ITP_HHV11 Inner tegument protein (sprot)


EPHA4_HUMAN Ephrin type-A receptor 4 (sprot)

An ephrin type-A receptor 4 that is encoded in the genome of human.


ZDH12_HUMAN Palmitoyltransferase ZDHHC12 (sprot)

A palmitoyltransferase ZDHHC12 that is encoded in the genome of human.


G protein-coupled peptide receptor activity

Combining with a peptide and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex.


cardiolipin binding

Binding to cardiolipin.


cytotoxic T cell pyroptotic process

Any pyroptotic process in a cytotoxic T cell.


killing by host of symbiont cells

Any process mediated by an organism that results in the death of cells in the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction.


gut granule

A lysosome-related organelle contained within the intestinal cells of the nematode C. elegans. Gut granules are acidified, birefringent, autofluorescent, and contain the vacuolar H+-ATPase. They also serve as sites of cellular zinc storage.


sensory perception of sound

The series of events required for an organism to receive an auditory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Sonic stimuli are detected in the form of vibrations and are processed to form a sound.


ossification

The formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance.


auditory receptor cell stereocilium organization

A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a stereocilium. A stereocilium is an actin-based protrusion from the apical surface of auditory hair cells.


stereocilium maintenance

The organization process that preserves a stereocilium in a stable functional or structural state.


regulation of actin filament length

Any process that controls the length of actin filaments in a cell.


inner ear development

The process whose specific outcome is the progression of the inner ear over time, from its formation to the mature structure.


morphogenesis of an epithelium

The process in which the anatomical structures of epithelia are generated and organized. An epithelium consists of closely packed cells arranged in one or more layers, that covers the outer surfaces of the body or lines any internal cavity or tube.


mucus secretion

The regulated release of mucus by the mucosa. Mucus is a viscous slimy secretion consisting of mucins and various inorganic salts dissolved in water, with suspended epithelial cells and leukocytes. The mucosa, or mucous membrane, is the membrane covered with epithelium that lines the tubular organs of the body. Mucins are carbohydrate-rich glycoproteins that have a lubricating and protective function.


inner ear morphogenesis

The process in which the anatomical structures of the inner ear are generated and organized. The inner ear is the structure in vertebrates that contains the organs of balance and hearing. It consists of soft hollow sensory structures (the membranous labyrinth) containing fluid (endolymph) surrounded by fluid (perilymph) and encased in a bony cavity (the bony labyrinth). It consists of two chambers, the sacculus and utriculus, from which arise the cochlea and semicircular canals respectively.


inhibition of non-skeletal tissue mineralization

A homeostatic process involved in the maintenance of non-mineral tissue, by preventing mineralization of non-skeletal tissue.


auditory receptor cell development

The process whose specific outcome is the progression of an auditory receptor cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate.


middle ear morphogenesis

The process in which the anatomical structures of the middle ear are generated and organized. The middle ear is the air-filled cavity within the skull of vertebrates that lies between the outer ear and the inner ear. It is linked to the pharynx (and therefore to outside air) via the Eustachian tube and in mammals contains the three ear ossicles, which transmit auditory vibrations from the outer ear (via the tympanum) to the inner ear (via the oval window).


voltage-gated potassium channel activity

Enables the transmembrane transfer of a potassium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded.


mechanosensitive monoatomic cation channel activity

Enables the transmembrane transfer of a monoatomic cation by a channel that opens in response to a mechanical stress.


voltage-gated calcium channel activity involved in positive regulation of presynaptic cytosolic calcium levels

Positive regulation of presynaptic cytosolic calcium ion concentrations via the directed movement of calcium ions across the plasma-membrane into the cytosol via the action of voltage-gated calcium ion channels. This is the first step in synaptic transmission.


stereocilium tip

A distinct compartment at the tip of a stereocilium, distal to the site of attachment to the apical cell surface. It consists of a dense matrix bridging the barbed ends of the stereocilium actin filaments with the overlying plasma membrane, is dynamic compared to the shaft, and is required for stereocilium elongation.


An alpha-amino-acid anion that is the conjugate base of L-glutamic acid, having anionic carboxy groups and a cationic amino group


Potassium ion

A monoatomic monocation obtained from potassium.


CAC1D_HUMAN Voltage-dependent L-type calcium channel subunit alpha-1D (sprot)

A voltage-dependent L-type calcium channel subunit alpha-1D that is encoded in the genome of human.


plasma membrane calcium-transporting ATPase 2 isoform WA (human)

A plasma membrane calcium-transporting ATPase 2 isoform 2 that is encoded in the genome of human.


AT2B1_HUMAN Plasma membrane calcium-transporting ATPase 1 (sprot)

A plasma membrane calcium-transporting ATPase 1 that is encoded in the genome of human.


KCMA1_HUMAN Calcium-activated potassium channel subunit alpha-1 (sprot)

A calcium-activated potassium channel subunit alpha-1 that is encoded in the genome of human.


regulation of ventricular cardiac muscle cell membrane repolarization

Any process that modulates the establishment or extent of a membrane potential in the polarizing direction towards the resting potential in a ventricular cardiomyocyte.


dynamin-1 isoform an (mouse)

A dynamin-1 (mouse) that is the a-type isoform.


synaptic transmission, glutamatergic

The vesicular release of glutamate from a presynapse, across a chemical synapse, the subsequent activation of glutamate receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse.


neuronal action potential

An action potential that occurs in a neuron.


intestine

biolink:GrossAnatomicalStructure biolink:AnatomicalEntity biolink:OrganismalEntity biolink:BiologicalEntity biolink:NamedThing biolink:PhysicalEssence biolink:SubjectOfInvestigation biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

Segment of the alimentary canal extending from the stomach to the anus and, in humans and other mammals, consists of two segments, the small intestine and the large intestine.


extracellular matrix organization

A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an extracellular matrix.


neural crest cell migration involved in autonomic nervous system development

Any neural crest cell migration that is involved in autonomic nervous system development.


cell development

The cellular developmental process in which a specific cell progresses from an immature to a mature state. Cell development start once cell commitment has taken place.


protein-lysine 6-oxidase activity

Catalysis of the reaction: peptidyl-L-lysyl-peptide + H2O + O2 = peptidyl-allysyl-peptide + NH3 + hydrogen peroxide.


regulation of extracellular matrix organization

Any process that modulates the frequency, rate or extent of extracellular matrix organization.


arterial system

biolink:AnatomicalEntity biolink:OrganismalEntity biolink:BiologicalEntity biolink:NamedThing biolink:PhysicalEssence biolink:SubjectOfInvestigation biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

The part of the cardiovascular system consisting of all arteries.


venous system

The part of the cardiovascular system consisting of all venous vessels. In vertebrates with a double circulation, this can be divided into systemic and pulmonary portions.


glomerular basement membrane

The layer of extracellular matrix that lies between the endothelium of the glomerular capillaries and the podocytes of the inner or visceral layer of the Bowman capsule; it is a fusion of the endothelial cell and podocyte basal laminas and acts as a physical barrier and an ion-selective filter.


FINC_HUMAN Fibronectin (sprot)

A fibronectin that is encoded in the genome of human.


CADH1_HUMAN Cadherin-1 (sprot)

A cadherin-1 that is encoded in the genome of human.


FBN1_HUMAN Fibrillin-1 (sprot)

A fibrillin-1 that is encoded in the genome of human.


A mucopolysaccharide composed of N-acetylglucosamine and glucuronic acid subunits. It is found in the connective tissues of vertebrates. A principal constituent of the extracellular matrix (ECM), it mediates the growth and metastasis of tumour cells.


CD44_HUMAN CD44 antigen (sprot)

A CD44 molecule that is encoded in the genome of human.


VCAM1_HUMAN Vascular cell adhesion protein 1 (sprot)

A vascular cell adhesion protein 1 that is encoded in the genome of human.


A divalent metal cation in which the metal is manganese.


galactosylceramide sulfate

A galactosylceramide substituted at O(3) of galactose by a sulfo group.


hydroxylapatite

A phosphate mineral with the formula Ca5(PO4)3(OH).


PTPRS_HUMAN Receptor-type tyrosine-protein phosphatase S (sprot)

A receptor-type tyrosine-protein phosphatase S that is encoded in the genome of human.


SPRC_HUMAN SPARC (sprot)

A SPARC protein that is encoded in the genome of human.


PAI1_HUMAN Plasminogen activator inhibitor 1 (sprot)

A plasminogen activator inhibitor 1 that is encoded in the genome of human.


NID1_HUMAN Nidogen-1 (sprot)

A nidogen-1 that is encoded in the genome of human.


PGS2_HUMAN Decorin (sprot)

A decorin that is encoded in the genome of human.


PGBM_HUMAN Basement membrane-specific heparan sulfate proteoglycan core protein (sprot)

A basement membrane-specific heparan sulfate proteoglycan core protein that is encoded in the genome of human.


OSTP_HUMAN Osteopontin (sprot)

An osteopontin that is encoded in the genome of human.


BASI_HUMAN Basigin (sprot)

A basigin that is encoded in the genome of human.


ELN_HUMAN Elastin (sprot)

An elastin that is encoded in the genome of human.


FBLN5_HUMAN Fibulin-5 (sprot)

A fibulin-5 that is encoded in the genome of human.


FGF2_HUMAN Fibroblast growth factor 2 (sprot)

A fibroblast growth factor 2 that is encoded in the genome of human.


mucosal addressin cell adhesion molecule 1 isoform 1 (human)

A mucosal addressin cell adhesion molecule 1 isoform 1 that is encoded in the genome of human.


COIA1_HUMAN Collagen alpha-1(XVIII) chain (sprot)

A collagen alpha-1(XVIII) chain that is encoded in the genome of human.


CD47_HUMAN Leukocyte surface antigen CD47 (sprot)

A CD47 molecule that is encoded in the genome of human.


JAM1_HUMAN Junctional adhesion molecule A (sprot)

A junctional adhesion molecule A that is encoded in the genome of human.


JAM3_HUMAN Junctional adhesion molecule C (sprot)

A junctional adhesion molecule C that is encoded in the genome of human.


PECA1_HUMAN Platelet endothelial cell adhesion molecule (sprot)

A platelet endothelial cell adhesion molecule that is encoded in the genome of human.


SIAL_HUMAN Bone sialoprotein 2 (sprot)

A bone sialoprotein 2 that is encoded in the genome of human.


LUM_HUMAN Lumican (sprot)

A lumican that is encoded in the genome of human.


TSP1_HUMAN Thrombospondin-1 (sprot)

A thrombospondin-1 that is encoded in the genome of human.


VTNC_HUMAN Vitronectin (sprot)

A vitronectin that is encoded in the genome of human.


TENA_HUMAN Tenascin (sprot)

A tenascin that is encoded in the genome of human.


AGRIN_HUMAN Agrin (sprot)

An agrin that is encoded in the genome of human.


NET4_HUMAN Netrin-4 (sprot)

A netrin-4 that is encoded in the genome of human.


DMD_HUMAN Dystrophin (sprot)

A dystrophin that is encoded in the genome of human.


NRX1A_HUMAN Neurexin-1 (sprot)

A neurexin-1-alpha that is encoded in the genome of human.


DMP1_HUMAN Dentin matrix acidic phosphoprotein 1 (sprot)

A dentin matrix acidic phosphoprotein 1 that is encoded in the genome of human.


DAG1_HUMAN Dystroglycan 1 (sprot)

A dystroglycan 1 that is encoded in the genome of human.


HPLN1_HUMAN Hyaluronan and proteoglycan link protein 1 (sprot)

A hyaluronan and proteoglycan link protein 1 that is encoded in the genome of human.


DSPP_HUMAN Dentin sialophosphoprotein (sprot)

A dentin sialophosphoprotein that is encoded in the genome of human.


NCAN_HUMAN Neurocan core protein (sprot)

A neurocan core protein that is encoded in the genome of human.


NCAM1_HUMAN Neural cell adhesion molecule 1 (sprot)

A neural cell adhesion molecule 1 that is encoded in the genome of human.


ICAM3_HUMAN Intercellular adhesion molecule 3 (sprot)

An intercellular adhesion molecule 3 that is encoded in the genome of human.


ICAM2_HUMAN Intercellular adhesion molecule 2 (sprot)

An intercellular adhesion molecule 2 that is encoded in the genome of human.


MATN3_HUMAN Matrilin-3 (sprot)

A matrilin-3 that is encoded in the genome of human.


MATN4_HUMAN Matrilin-4 (sprot)

A matrilin-4 that is encoded in the genome of human.


CO4A1_HUMAN Collagen alpha-1(IV) chain (sprot)

A collagen alpha-1(IV) chain that is encoded in the genome of human.


ICAM1_HUMAN Intercellular adhesion molecule 1 (sprot)

An intercellular adhesion molecule 1 that is encoded in the genome of human.


CO4A2_HUMAN Collagen alpha-2(IV) chain (sprot)

A collagen alpha-2(IV) chain that is encoded in the genome of human.


TGFB3_HUMAN Transforming growth factor beta-3 proprotein (sprot)

A TGF-beta 3 that is encoded in the genome of human.


CSPG2_HUMAN Versican core protein (sprot)

A versican core protein that is encoded in the genome of human.


PGCA_HUMAN Aggrecan core protein (sprot)

An aggrecan core protein that is encoded in the genome of human.


PGS1_HUMAN Biglycan (sprot)

A biglycan that is encoded in the genome of human.


MATN1_HUMAN Cartilage matrix protein (sprot)

A cartilage matrix protein that is encoded in the genome of human.


FBN2_HUMAN Fibrillin-2 (sprot)

A fibrillin-2 that is encoded in the genome of human.


CO4A4_HUMAN Collagen alpha-4(IV) chain (sprot)

A collagen alpha-4(IV) chain that is encoded in the genome of human.


MFAP2_HUMAN Microfibrillar-associated protein 2 (sprot)

A microfibrillar-associated protein 2 that is encoded in the genome of human.


TGFB2_HUMAN Transforming growth factor beta-2 proprotein (sprot)

A TGF-beta 2 that is encoded in the genome of human.


CO4A3_HUMAN Collagen alpha-3(IV) chain (sprot)

A collagen alpha-3(IV) chain that is encoded in the genome of human.


FMOD_HUMAN Fibromodulin (sprot)

A fibromodulin that is encoded in the genome of human.


MFAP5_HUMAN Microfibrillar-associated protein 5 (sprot)

A microfibrillar-associated protein 5 that is encoded in the genome of human.


NID2_HUMAN Nidogen-2 (sprot)

A nidogen-2 that is encoded in the genome of human.


ICAM4_HUMAN Intercellular adhesion molecule 4 (sprot)

An intercellular adhesion molecule 4 that is encoded in the genome of human.


FBN3_HUMAN Fibrillin-3 (sprot)

A fibrillin-3 that is encoded in the genome of human.


PGCB_HUMAN Brevican core protein (sprot)

A brevican core protein that is encoded in the genome of human.


ASPN_HUMAN Asporin (sprot)

An asporin that is encoded in the genome of human.


ICAM5_HUMAN Intercellular adhesion molecule 5 (sprot)

An intercellular adhesion molecule 5 that is encoded in the genome of human.


skin development

The process whose specific outcome is the progression of the skin over time, from its formation to the mature structure. The skin is the external membranous integument of an animal. In vertebrates the skin generally consists of two layers, an outer nonsensitive and nonvascular epidermis (cuticle or skarfskin) composed of cells which are constantly growing and multiplying in the deeper, and being thrown off in the superficial layers, as well as an inner vascular dermis (cutis, corium or true skin) composed mostly of connective tissue.


in utero embryonic development

The process whose specific outcome is the progression of the embryo in the uterus over time, from formation of the zygote in the oviduct, to birth. An example of this process is found in Mus musculus.


cartilage development

The process whose specific outcome is the progression of a cartilage element over time, from its formation to the mature structure. Cartilage elements are skeletal elements that consist of connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate.


collagen fibril organization

Any process that determines the size and arrangement of collagen fibrils within an extracellular matrix.


chondrocyte differentiation

The process in which a chondroblast acquires specialized structural and/or functional features of a chondrocyte. A chondrocyte is a polymorphic cell that forms cartilage.


limb joint morphogenesis

The process in which the anatomical structures of a limb joint are generated and organized. A limb joint is a flexible region that separates the rigid sections of a limb to allow movement in a controlled manner.


A chondroitin sulfate in which the site of sulfation is carbon 4 of the N-acetylgalactosamine (GalNAc) sugar.


beta-1,4-galactosyltransferase 1 isoform 1 (mouse)

A beta-1,4-galactosyltransferase 1 isoform 1 that is encoded in the genome of mouse.


migratory enteric neural crest cell

A neural crest cell that gives rise to cells of the enteric nervous system.


neural crest cell migration

The characteristic movement of cells from the dorsal ridge of the neural tube to a variety of locations in a vertebrate embryo.


enteric nervous system development

The process whose specific outcome is the progression of the enteric nervous system over time, from its formation to the mature structure. The enteric nervous system is composed of two ganglionated neural plexuses in the gut wall which form one of the three major divisions of the autonomic nervous system. The enteric nervous system innervates the gastrointestinal tract, the pancreas, and the gallbladder. It contains sensory neurons, interneurons, and motor neurons. Thus the circuitry can autonomously sense the tension and the chemical environment in the gut and regulate blood vessel tone, motility, secretions, and fluid transport. The system is itself governed by the central nervous system and receives both parasympathetic and sympathetic innervation.


node of Ranvier

An axon part that is a gap in the myelin where voltage-gated sodium channels cluster and saltatory conduction is executed.


follicular dendritic cell

A cell with extensive dendritic processes found in the B cell areas (primary follicles and germinal centers) of lymphoid tissue. They are unrelated to the dendritic cell associated with T cells. Follicular dendritic cells have Fc receptors and C3b receptors, but unlike other dendritic cells, they do not process or present antigen in a way that allows recognition by T cells. Instead, they hold antigen in the form of immune complexes on their surfaces for long periods and can present antigen to B cells during an immune response.


renal system

The renal system in an anatomical system that maintains fluid balance and contributes to electrolyte balance, acid/base balance, and disposal of nitrogenous waste products.


cochlin, signal peptide removed form (mouse)

A cochlin (mouse) that the signal peptide has been removed. UniProtKB:Q62507, 26-552.


cochlin p40 (mouse)

A cochlin, signal peptide removed form (mouse) that results from further cleavage of the LCCL domain (Pfam:PF03815) after aggrecanases proteolytic activity. UniProtKB:Q62507, 135-552.


unique cartilage matrix-associated protein isoform 1 (mouse)

A unique cartilage matrix-associated protein isoform 1 that is encoded in the genome of mouse.


interleukin-1 receptor-like 1 isoform B (mouse)

An interleukin-1 receptor-like 1 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P14719-2.


Q810U6_MOUSE Phosphacan short isoform (trembl)

A receptor-type tyrosine-protein phosphatase zeta (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q810U6.


transforming growth factor beta receptor binding

Binding to a transforming growth factor beta receptor.


regulation of gene expression

Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA).


nervous system development

The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state.


transmembrane receptor protein tyrosine kinase signaling pathway

The series of molecular signals initiated by an extracellular ligand binding to a receptor on the surface of the target cell where the receptor possesses tyrosine kinase activity, and ending with the regulation of a downstream cellular process, e.g. transcription.


positive regulation of cell population proliferation

Any process that activates or increases the rate or extent of cell proliferation.


peristalsis

A wavelike sequence of involuntary muscular contraction and relaxation that passes along a tubelike structure, such as the intestine, impelling the contents onwards.


peripheral nervous system development

The process whose specific outcome is the progression of the peripheral nervous system over time, from its formation to the mature structure. The peripheral nervous system is one of the two major divisions of the nervous system. Nerves in the PNS connect the central nervous system (CNS) with sensory organs, other organs, muscles, blood vessels and glands.


positive regulation of cell differentiation

Any process that activates or increases the frequency, rate or extent of cell differentiation.


organ induction

The interaction of two or more cells or tissues that causes them to change their fates and specify the development of an organ.


ureteric bud development

The process whose specific outcome is the progression of the ureteric bud over time, from its formation to the mature structure.


regulation of morphogenesis of a branching structure

Any process that modulates the rate, frequency, or extent of branching morphogenesis, the process in which the anatomical structures of branches are generated and organized.


postsynaptic membrane organization

A process which results in the assembly, arrangement of constituent parts, or disassembly of a postsynaptic membrane, the specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft).


basement membrane

A collagen-containing extracellular matrix consisting of a thin layer of dense material found in various animal tissues interposed between the cells and the adjacent connective tissue. It consists of the basal lamina plus an associated layer of reticulin fibers.


An extracellular matrix consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that provides not only essential physical scaffolding for the cellular constituents but can also initiate crucial biochemical and biomechanical cues required for tissue morphogenesis, differentiation and homeostasis. The components are secreted by cells in the vicinity and form a sheet underlying or overlying cells such as endothelial and epithelial cells.


peptidase activator activity

Binds to and increases the activity of a peptidase.


proteoglycan binding

Binding to a proteoglycan, any glycoprotein in which the carbohydrate units are glycosaminoglycans.


cell-matrix adhesion

The binding of a cell to the extracellular matrix via adhesion molecules.


cell-substrate junction assembly

The aggregation, arrangement and bonding together of a set of components to form a junction between a cell and its substrate.


positive regulation of axon extension

Any process that activates or increases the frequency, rate or extent of axon extension.


The binding of a cell to the extracellular matrix via adhesion molecules that do not require the presence of calcium for the interaction.


collagen binding

Binding to collagen, a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals. Collagen is highly enriched in glycine (some regions are 33% glycine) and proline, occurring predominantly as 3-hydroxyproline (about 20%).


GDNF_HUMAN Glial cell line-derived neurotrophic factor (sprot)

A glial cell line-derived neurotrophic factor that is encoded in the genome of human.


GFAP_HUMAN Glial fibrillary acidic protein (sprot)

A glial fibrillary acidic protein that is encoded in the genome of human.


platelet degranulation

The regulated exocytosis of secretory granules containing preformed mediators such as histamine and serotonin by a platelet.


RPGF3_HUMAN Rap guanine nucleotide exchange factor 3 (sprot)

A Rap guanine nucleotide exchange factor 3 that is encoded in the genome of human.


RPGF4_HUMAN Rap guanine nucleotide exchange factor 4 (sprot)

A Rap guanine nucleotide exchange factor 4 that is encoded in the genome of human.


camera-type eye development

The process whose specific outcome is the progression of the camera-type eye over time, from its formation to the mature structure. The camera-type eye is an organ of sight that receives light through an aperture and focuses it through a lens, projecting it on a photoreceptor field.


neural crest cell differentiation

The process in which a relatively unspecialized cell acquires specialized features of a neural crest cell.


RNA polymerase I activity

Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template that contains an RNA polymerase I specific promoter to direct initiation and catalyzes DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'.


melanocyte

A pigment cell derived from the neural crest. Contains melanin-filled pigment granules, which gives a brown to black appearance.


migratory cranial neural crest cell

Cell that is part of the migratory cranial neural crest population. Migratory cranial neural crest cells develop from premigratory cranial neural crest cells and have undergone epithelial to mesenchymal transition and delamination.


neuroblast migration

The orderly movement of a neuroblast from one site to another, often during the development of a multicellular organism or multicellular structure. A neuroblast is any cell that will divide and give rise to a neuron.


calcium channel activity

Enables the facilitated diffusion of a calcium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism.


neural crest derived neuroblast

A neuroblast derived from a neural crest cell.


lung

Respiration organ that develops as an outpocketing of the esophagus.


respiratory system mucosa

The mucous membrane lining the respiratory tract.