regulation of myoblast differentiation

Any process that modulates the frequency, rate or extent of myoblast differentiation. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers.


regulation of cell growth by extracellular stimulus

biolink:BiologicalProcess biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:NamedThing biolink:Occurrent biolink:OntologyClass biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

Any process in which external signals modulate the frequency, rate or extent of cell growth, the irreversible increase in size of a cell over time.


tangential migration from the subventricular zone to the olfactory bulb

The migration of cells in the telencephalon from the subventricular zone to the olfactory bulb in which cells move orthogonally to the direction of radial migration and do not use radial glial cell processes as substrates for migration.


positive thymic T cell selection

The process of sparing immature T cells in the thymus which react with self-MHC protein complexes with low affinity levels from apoptotic death.


positive regulation of phospholipase activity

Any process that increases the frequency, rate or extent of phospholipase activity, the hydrolysis of a phospholipid.


actin-mediated cell contraction

The actin filament-based process in which cytoplasmic actin filaments slide past one another resulting in contraction of all or part of the cell body.


response to methylglyoxal

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methylglyoxal stimulus. Methylglyoxal is a 2-oxoaldehyde derived from propanal.


chromosome passenger complex

biolink:CellularComponent biolink:AnatomicalEntity biolink:OrganismalEntity biolink:BiologicalEntity biolink:NamedThing biolink:PhysicalEssence biolink:SubjectOfInvestigation biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

A eukaryotically conserved protein complex that localizes to kinetochores in early mitosis, the spindle mid-zone in anaphase B and to the telophase midbody. It has been proposed that the passenger complex coordinates various events based on its location to different structures during the course of mitosis. Complex members include the BIR-domain-containing protein Survivin, Aurora kinase, INCENP and Borealin.


biolink:MolecularActivity biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:NamedThing biolink:Occurrent biolink:OntologyClass biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: chloride(in) + HCO3-(out) = chloride(out) + HCO3-(in).


kidney outer medulla collecting duct intercalated cell

biolink:Cell biolink:AnatomicalEntity biolink:OrganismalEntity biolink:BiologicalEntity biolink:NamedThing biolink:PhysicalEssence biolink:SubjectOfInvestigation biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

Intercalated cell that is part of some outer medullary collecting duct. It is known in some mammalian species that this cell may contribute in the maintenance of acid/base homeostasis.


dephosphorylation

The process of removing one or more phosphoric (ester or anhydride) residues from a molecule.


negative regulation of phosphoprotein phosphatase activity

Any process that stops or reduces the activity of a phosphoprotein phosphatase.


myocardin isoform 3 (mouse)

A myocardin (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q8VIM5-3.


myocardin isoform 4 (mouse)

A myocardin (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q8VIM5-4.


IQEC2_HUMAN IQ motif and SEC7 domain-containing protein 2 (sprot)

An IQ motif and SEC7 domain-containing protein 2 that is encoded in the genome of human.


chaperone-mediated protein complex assembly

The aggregation, arrangement and bonding together of a set of components to form a protein complex, mediated by chaperone molecules that do not form part of the finished complex.


cellular response to corticosterone stimulus

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a corticosterone stimulus. Corticosterone is a 21 carbon steroid hormone of the corticosteroid type, produced in the cortex of the adrenal glands. In many species, corticosterone is the principal glucocorticoid, involved in regulation of fuel metabolism, immune reactions, and stress responses.


negative regulation of actin filament depolymerization

Any process that stops, prevents, or reduces the frequency, rate or extent of actin depolymerization.


negative regulation of telomere maintenance

Any process that stops, prevents, or reduces the frequency, rate or extent of a process that affects and monitors the activity of telomeric proteins and the length of telomeric DNA.


transcription elongation by RNA polymerase I

The extension of an RNA molecule after transcription initiation and promoter clearance at an RNA polymerase I specific promoter by the addition of ribonucleotides catalyzed by RNA polymerase I.


negative regulation of mast cell cytokine production

Any process that stops, prevents, or reduces the frequency, rate, or extent of mast cell cytokine production.


positive regulation of mast cell cytokine production

Any process that activates or increases the frequency, rate, or extent of mast cell cytokine production.


left-handed Z-DNA binding

Binding to DNA in the Z form, i.e. a left-handed helix in which the phosphate backbone zigzags.


negative regulation of post-transcriptional gene silencing by regulatory ncRNA

Any process that stops, prevents or reduces the frequency, rate or extent of post-transcriptional gene silencing by RNA.


RISC complex assembly

The process in which a single-stranded small RNA is incorporated within the RNA-initiated silencing complex (RISC). The assembly includes the maturation of the small RNA, the stabilization of the complex by accessory proteins of the RISC complex, duplex separation and the release of the second strand, forming a base-pairing completent complex that mediates gene silencing by small RNA.


base conversion or substitution editing

Any base modification or substitution events that result in alterations in the coding potential or structural properties of RNAs as a result of changes in the base-pairing properties of the modified ribonucleoside(s).


somatic diversification of immune receptors via somatic mutation

The process in which immune receptor genes are diversified through somatic mutation.


positive regulation of T cell cytokine production

Any process that activates or increases the frequency, rate, or extent of T cell cytokine production.


phosphatidylinositol trisphosphate phosphatase activity

Catalysis of the reaction: phosphatidylinositol trisphosphate + H2O = phosphatidylinositol bisphosphate + phosphate.


PTB domain binding

Binding to a phosphotyrosine-binding (PTB) Binding to a phosphotyrosine-bindin domain.


claudin-18 isoform mA2.1 (mouse)

A claudin-18 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P56857-3.


syntaxin-3 binding

Binding to a syntaxin-3 SNAP receptor.


poly(U) RNA binding

Binding to a sequence of uracil residues in an RNA molecule.


glycerol transmembrane transport

The directed movement of glycerol across a membrane. Glycerol is 1,2,3-propanetriol, a sweet, hygroscopic, viscous liquid, widely distributed in nature as a constituent of many lipids.


interleukin-1 receptor binding

Binding to an interleukin-1 receptor.


IL1R1_MOUSE Interleukin-1 receptor type 1 (sprot)

An interleukin-1 receptor type 1 that is encoded in the genome of mouse.


negative regulation of toll-like receptor 2 signaling pathway

Any process that stops, prevents, or reduces the frequency, rate, or extent of toll-like receptor 2 signaling pathway.


IL1R2_MOUSE Interleukin-1 receptor type 2 (sprot)

An interleukin-1 receptor type 2 that is encoded in the genome of mouse.


calpain-3 isoform Short (mouse)

A calpain-3 isoform 2 that is encoded in the genome of mouse.


N-formyl peptide receptor activity

Combining with an N-formyl peptide to initiate a change in cell activity.


cellular response to pheromone

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pheromone stimulus.


interleukin-11 binding

Binding to interleukin-11.


IL11_MOUSE Interleukin-11 (sprot)

An interleukin-11 that is encoded in the genome of mouse.


EGLN_MOUSE Endoglin (sprot)

An endoglin that is encoded in the genome of mouse.


phosphorus-oxygen lyase activity

Catalysis of the cleavage of a phosphorus-oxygen bond by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond.


regulation of Ral protein signal transduction

Any process that modulates the frequency, rate or extent of Ral protein signal transduction.


organophosphate metabolic process

The chemical reactions and pathways involving organophosphates, any phosphate-containing organic compound.


cell adhesion molecule binding

Binding to a cell adhesion molecule.


positive regulation of cyclin-dependent protein serine/threonine kinase activity

Any process that activates or increases the frequency, rate or extent of CDK activity.


myosin II complex

A myosin complex containing two class II myosin heavy chains, two myosin essential light chains and two myosin regulatory light chains. Also known as classical myosin or conventional myosin, the myosin II class includes the major muscle myosin of vertebrate and invertebrate muscle, and is characterized by alpha-helical coiled coil tails that self assemble to form a variety of filament structures.


leukotriene production involved in inflammatory response

The synthesis or release of any leukotriene following a stimulus as part of an inflammatory response, resulting in an increase in its intracellular or extracellular levels.


calcium-dependent protein binding

Binding to a protein or protein complex in the presence of calcium.


WIPI3_HUMAN WD repeat domain phosphoinositide-interacting protein 3 (sprot)

A WD repeat domain phosphoinositide-interacting protein 3 that is encoded in the genome of human.


WIPI4_HUMAN WD repeat domain phosphoinositide-interacting protein 4 (sprot)

A WD repeat domain phosphoinositide-interacting protein 4 that is encoded in the genome of human.


regulation of trans-synaptic signaling by endocannabinoid, modulating synaptic transmission

Any process that modulates the frequency, rate or extent of trans-synaptic signaling by endocannabinoid, modulating synaptic transmission.


observational learning

Learning that occurs through observing the behavior of others.


gamma-aminobutyric acid secretion, neurotransmission

The regulated release of gamma-aminobutyric acid by a cell, in which the gamma-aminobutyric acid acts as a neurotransmitter.


PLXA4_MOUSE Plexin-A4 (sprot)

A plexin-A4 that is encoded in the genome of mouse.


negative regulation of transcription by RNA polymerase III

Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase III.


thoracic cavity

biolink:AnatomicalEntity biolink:OrganismalEntity biolink:BiologicalEntity biolink:NamedThing biolink:PhysicalEssence biolink:SubjectOfInvestigation biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

The part of the coelemic cavity lumen that is enclosed by the walls of the thorax.


Hsp90 protein binding

Binding to Hsp90 proteins, any of a group of heat shock proteins around 90kDa in size.


ribosomal protein import into nucleus

The directed movement of a ribosomal protein from the cytoplasm into the nucleus, across the nuclear membrane. At least some ribosomal proteins, including rpl12, uses the importin 11 pathway as a major route into the nucleus.


IMA8_MOUSE Importin subunit alpha-8 (sprot)

An importin subunit alpha-8 that is encoded in the genome of mouse.


RL11_MOUSE Large ribosomal subunit protein uL5 (sprot)

A 60S ribosomal protein L11 that is encoded in the genome of mouse.


positive regulation of calcium-dependent cell-cell adhesion

Any process that activates or increases the frequency, rate or extent of calcium-dependent cell-cell adhesion.


L-proline import across plasma membrane

The directed movement of L-proline from outside of a cell, across the plasma membrane and into the cytosol.


acetyl-CoA biosynthetic process

The chemical reactions and pathways resulting in the formation of acetyl-CoA, a derivative of coenzyme A in which the sulfhydryl group is acetylated.


negative regulation of alpha-beta T cell proliferation

Any process that stops, prevents, or reduces the frequency, rate or extent of alpha-beta T cell proliferation.


sodium channel inhibitor activity

Binds to and stops, prevents, or reduces the activity of a sodium channel.


cellular response to histamine

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a histamine stimulus. Histamine, the biogenic amine 2-(1H-imidazol-4-yl)ethanamine, is involved in local immune responses as well as regulating physiological function in the gut and acting as a neurotransmitter.


interleukin-11 receptor binding

Binding to an interleukin-11 receptor.


I11RA_MOUSE Interleukin-11 receptor subunit alpha-1 (sprot)

An interleukin-11 receptor subunit alpha-1 that is encoded in the genome of mouse.


metalloendopeptidase inhibitor activity

Binds to and stops, prevents or reduces the activity of metalloendopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide bonds in a polypeptide chain and contain a chelated metal ion at their active sites which is essential to their catalytic activity.


regulation of cell projection assembly

Any process that modulates the rate, frequency, or extent of cell projection assembly.


positive regulation of platelet-derived growth factor receptor-beta signaling pathway

Any process that activates or increases the frequency, rate or extent of platelet-derived growth factor receptor-beta signaling pathway.


low voltage-gated calcium channel activity

Enables the transmembrane transfer of a calcium ion by a low voltage-gated channel. A low voltage-gated channel is a channel whose open state is dependent on low voltage across the membrane in which it is embedded.


response to nickel cation

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nickel cation stimulus.


TBA4A_MOUSE Tubulin alpha-4A chain (sprot)

A tubulin alpha-4A chain that is encoded in the genome of mouse.


natural killer cell activation involved in immune response

The change in morphology and behavior of a natural killer cell resulting from exposure a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response.


regulation of toll-like receptor signaling pathway

Any process that modulates the frequency, rate, or extent of toll-like receptor signaling pathway.


Octanoate

A straight-chain saturated fatty acid anion that is the conjugate base of octanoic acid (caprylic acid); believed to block adipogenesis.


positive regulation of NK T cell activation

Any process that activates or increases the frequency, rate or extent of natural killer T cell activation.


endogenous lipid antigen binding

Binding to an endogenous cellular lipid antigen.


T cell receptor binding

Binding to a T cell receptor, the antigen-recognizing receptor on the surface of T cells.


regulation of smooth muscle cell migration

Any process that modulates the frequency, rate or extent of smooth muscle cell migration.


negative regulation of smooth muscle cell migration

Any process that stops, prevents, or reduces the frequency, rate or extent of smooth muscle cell migration.


cerebellar granule cell precursor tangential migration

The early migration of granule cell precursors in which cells move orthogonal to the direction of radial migration and ultimately cover the superficial zone of the cerebellar primordium.


negative regulation of neutrophil degranulation

Any process that stops, prevents, or reduces the rate of neutrophil degranulation.


inner dynein arm

Inner arm structure present on the outer doublet microtubules of ciliary and flagellar axonemes. The structure of inner dynein arms is complex and may vary within the axoneme. Inner dynein arms are heteromeric, comprising 8 different heavy chains and various subunits. Inner and outer dynein arms have different functions in the generation of microtubule-based motility.


regulation of microvillus assembly

A process that modulates the formation of a microvillus.


secretory cell

A cell that specializes in controlled release of one or more substances.


GDNF family receptor alpha-2 isoform 4 (mouse)

A GDNF family receptor alpha-2 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O08842-2.


extracellularly glutamate-gated chloride channel activity

Enables the transmembrane transfer of a chloride ion by a channel that opens when glutamate is bound by the channel complex or one of its constituent parts on the extracellular side of the plasma membrane.


sodium:inorganic phosphate symporter activity

Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + inorganic phosphate(out) = Na+(in) + inorganic phosphate(in).


HFE_HUMAN Hereditary hemochromatosis protein (sprot)

A hereditary hemochromatosis protein that is encoded in the genome of human.


TFR2_HUMAN Transferrin receptor protein 2 (sprot)

A transferrin receptor protein 2 that is encoded in the genome of human.


cardiogenic plate

The first recognizable structure derived from the heart field.


response to cycloheximide

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cycloheximide stimulus. Cycloheximide (actidione) is an antibiotic produced by some Streptomyces species which interferes with protein synthesis in eukaryotes.


apoptotic process in bone marrow cell

The apoptotic process in cells in the bone marrow.


protein arginine N-methyltransferase 1 isoform V1 (mouse)

A protein arginine N-methyltransferase 1 isoform V1 that is encoded in the genome of mouse.


protein-arginine omega-N asymmetric methyltransferase activity

Catalysis of the addition of a second methyl group to methylated peptidyl-arginine. Methylation is on the same terminal nitrogen (omega nitrogen) residue that was previously methylated, resulting in asymmetrical peptidyl-N(omega),N(omega)-dimethylated arginine residues.


peptidyl-arginine methylation, to asymmetrical-dimethyl arginine

The process of methylation of peptidyl-arginine to form peptidyl-N(omega),N(omega)-dimethyl-L-arginine.


protein-arginine omega-N monomethyltransferase activity

Catalysis of the addition of a methyl group to either of the unmethylated terminal nitrogen atoms (also called omega nitrogen) in peptidyl-arginine to form an omega-N-G-monomethylated arginine residue. The reaction is S-adenosyl-L-methionine + [protein]-L-arginine = S-adenosyl-L-homocysteine + [protein]-Nomega-methyl-L-arginine.


peptidyl-arginine omega-N-methylation

The addition of a methyl group onto a terminal nitrogen (omega nitrogen) atom of an arginine residue in a protein.


protein arginine N-methyltransferase 1 isoform V2 (mouse)

A protein arginine N-methyltransferase 1 isoform V2 that is encoded in the genome of mouse.


CD8-positive, gamma-delta intraepithelial T cell differentiation

The process in which a precursor cell type acquires the specialized features of a CD8-positive, gamma-delta intraepithelial T cell. Intraepithelial T cells are found among epithelial cells in mucosal areas and have distinct phenotypes and developmental pathways.


negative regulation of leukocyte chemotaxis

Any process that stops, prevents, or reduces the frequency, rate, or extent of leukocyte chemotaxis.


CD8-positive, alpha-beta intraepithelial T cell differentiation

The process in which a precursor cell type acquires the specialized features of a CD8-positive, alpha-beta intraepithelial T cell. Intraepithelial T cells are found among epithelial cells in mucosal areas and have distinct phenotypes and developmental pathways.


glucosidase II complex

A heterodimeric complex that catalyzes the trimming of glucose residues from N-linked core glycans on newly synthesized glycoproteins.


nuclear stress granule

A dense aggregation in the nucleus composed of proteins and RNAs that appear when the cell is under stress.


polarity specification of anterior/posterior axis

Any process resulting in the establishment of polarity along the anterior/posterior axis.


MTMR9_HUMAN Myotubularin-related protein 9 (sprot)

A myotubularin-related protein 9 that is encoded in the genome of human.


MTMRC_HUMAN Myotubularin-related protein 12 (sprot)

A myotubularin-related protein 12 that is encoded in the genome of human.


MTMRA_HUMAN Myotubularin-related protein 10 (sprot)

A myotubularin-related protein 10 that is encoded in the genome of human.


MTMR8_HUMAN Myotubularin-related protein 8 (sprot)

A myotubularin-related protein 8 that is encoded in the genome of human.


PKHA8_HUMAN Pleckstrin homology domain-containing family A member 8 (sprot)

A pleckstrin homology domain-containing family A member 8 that is encoded in the genome of human.


PKHA4_HUMAN Pleckstrin homology domain-containing family A member 4 (sprot)

A pleckstrin homology domain-containing family A member 4 that is encoded in the genome of human.


PKHA5_HUMAN Pleckstrin homology domain-containing family A member 5 (sprot)

A pleckstrin homology domain-containing family A member 5 that is encoded in the genome of human.


PKHA3_HUMAN Pleckstrin homology domain-containing family A member 3 (sprot)

A pleckstrin homology domain-containing family A member 3 that is encoded in the genome of human.


PKHA6_HUMAN Pleckstrin homology domain-containing family A member 6 (sprot)

A pleckstrin homology domain-containing family A member 6 that is encoded in the genome of human.


positive regulation of kinase activity

Any process that activates or increases the frequency, rate or extent of kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule.


nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

A major pathway of degradation of nuclear-transcribed mRNAs that proceeds through a series of ordered steps that includes poly(A) tail shortening and that can regulate mRNA stability.


metal ion transport

The directed movement of metal ions, any metal ion with an electric charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


Merkel cell

A modified epidermal cell located in the stratum basale. They are found mostly in areas where sensory perception is acute. Merkel cells are closely associated with an expanded terminal bulb of an afferent myelinated nerve fiber.


prickle cell

A cell with delicate radiating processes known as desmosomes that form intercellular bridges between other cells of this type. This cell type forms the stratum spinosum (prickle cell layer). A function of this cell is to generate keratin.


positive regulation of NAD+ ADP-ribosyltransferase activity

Any process that activates or increases the frequency, rate or extent of NAD+ ADP-ribosyltransferase activity.


regulation of development, heterochronic

Any process that modulates the consistent predetermined time point at which an integrated living unit or organism progresses from an initial condition to a later condition and the rate at which this time point is reached.


handplate apical ectodermal ridge

An apical ectodermal ridge that is part of a handplate.


reproductive system development

The progression of the reproductive system over time from its formation to the mature structure. The reproductive system consists of the organs that function in reproduction.


NDUF4_HUMAN NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 4 (sprot)

An NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 4 that is encoded in the genome of human.


NDUS3_HUMAN NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial (sprot)

An NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial that is encoded in the genome of human.


TIDC1_HUMAN Complex I assembly factor TIMMDC1, mitochondrial (sprot)

A complex I assembly factor TIMMDC1, mitochondrial that is encoded in the genome of human.


NDUF6_HUMAN NADH dehydrogenase (ubiquinone) complex I, assembly factor 6 (sprot)

An NADH dehydrogenase (ubiquinone) complex I, assembly factor 6 that is encoded in the genome of human.


NUBPL_HUMAN Iron-sulfur protein NUBPL (sprot)

A nucleotide-binding protein-like that is encoded in the genome of human.


NU5M_HUMAN NADH-ubiquinone oxidoreductase chain 5 (sprot)

An NADH-ubiquinone oxidoreductase chain 5 that is encoded in the genome of human.


NU4M_HUMAN NADH-ubiquinone oxidoreductase chain 4 (sprot)

An NADH-ubiquinone oxidoreductase chain 4 that is encoded in the genome of human.


NDUAC_HUMAN NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 (sprot)

An NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 that is encoded in the genome of human.


NDUV2_HUMAN NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial (sprot)

An NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial that is encoded in the genome of human.


NDUS5_HUMAN NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 (sprot)

An NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 that is encoded in the genome of human.


NDUB6_HUMAN NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 (sprot)

An NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 that is encoded in the genome of human.


NU6M_HUMAN NADH-ubiquinone oxidoreductase chain 6 (sprot)

An NADH-ubiquinone oxidoreductase chain 6 that is encoded in the genome of human.


NDUS4_HUMAN NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial (sprot)

An NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial that is encoded in the genome of human.


NDUV3_HUMAN NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial (sprot)

An NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial that is encoded in the genome of human.


NDUS6_HUMAN NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial (sprot)

An NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial that is encoded in the genome of human.


NDUF2_HUMAN NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 2 (sprot)

An NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 2 that is encoded in the genome of human.


NDUV1_HUMAN NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial (sprot)

An NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial that is encoded in the genome of human.


NU1M_HUMAN NADH-ubiquinone oxidoreductase chain 1 (sprot)

An NADH-ubiquinone oxidoreductase chain 1 that is encoded in the genome of human.


NDUF3_HUMAN NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 3 (sprot)

An NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 3 that is encoded in the genome of human.


NDUF7_HUMAN Protein arginine methyltransferase NDUFAF7, mitochondrial (sprot)

A protein arginine methyltransferase NDUFAF7, mitochondrial that is encoded in the genome of human.


NDUF5_HUMAN Arginine-hydroxylase NDUFAF5, mitochondrial (sprot)

An arginine-hydroxylase NDUFAF5, mitochondrial that is encoded in the genome of human.


NDUS8_HUMAN NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial (sprot)

An NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial that is encoded in the genome of human.


NDUS7_HUMAN NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial (sprot)

An NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial that is encoded in the genome of human.


NDUS2_HUMAN NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial (sprot)

An NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial that is encoded in the genome of human.


NDUS1_HUMAN NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial (sprot)

An NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial that is encoded in the genome of human.


nucleologenesis

A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a nucleolus, a small, dense body one or more of which are present in the nucleus of eukaryotic cells.


G protein-coupled neurotensin receptor activity

Combining with the tridecapeptide neurotensin to initiate a G-protein mediated change in cell activity. A G-protein is a signal transduction molecule that alternates between an inactive GDP-bound and an active GTP-bound state.


intermediate filament cytoskeleton

Cytoskeletal structure made from intermediate filaments, typically organized in the cytosol as an extended system that stretches from the nuclear envelope to the plasma membrane. Some intermediate filaments run parallel to the cell surface, while others traverse the cytosol; together they form an internal framework that helps support the shape and resilience of the cell.


MutSalpha complex binding

Binding to a MutSalpha mismatch repair complex.


MutLalpha complex binding

Binding to a MutLalpha mismatch repair complex.


protein carboxylation

The addition of a carboxy group to a protein amino acid.


regulation of germinal center formation

Any process that modulates the frequency, rate, or extent of germinal center formation.


vascular endothelial growth factor receptor 3 binding

Binding to a vascular endothelial growth factor receptor 3.


positive regulation of syncytium formation by plasma membrane fusion

Any process that increases the frequency, rate or extent of the formation of a syncytium, a mass of cytoplasm containing several nuclei enclosed within a single plasma membrane, by the fusion of the plasma membranes of two or more individual cells.


syncytiotrophoblast cell

A cell from the outer syncytial layer of the trophoblast of an early mammalian embryo, directly associated with the maternal blood supply. It secretes hCG in order to maintain progesterone secretion and sustain a pregnancy.


chorion-specific transcription factor GCMa acetylated 1 (mouse)

A chorion-specific transcription factor GCMa acetylated 1 in mouse. UniProtKB:P70348, Lys-367/Lys-406, MOD:00064.


chorionic trophoblast cell differentiation

The process in which relatively unspecialized cells of the ectoplacental cone acquire specialized structural and/or functional features that characterize chorionic trophoblasts. These cells will migrate towards the spongiotrophoblast layer and give rise to syncytiotrophoblasts of the labyrinthine layer.


regulation of chorionic trophoblast cell proliferation

Any process that modulates the frequency, rate or extent of chorionic trophoblast cell proliferation.


chorionic trophoblast cell proliferation

The multiplication or reproduction of chorionic trophoblast cells, resulting in the expansion of their population.


positive T cell selection

The process of sparing immature T cells which react with self-MHC protein complexes with low affinity levels from apoptotic death.


positive regulation of axon regeneration

Any process that activates, maintains or increases the rate of axon regeneration.


pericardial cavity

A potential space between the visceral and parietal layers of the pericardium.


positive regulation of mesoderm development

Any process that activates or increases the frequency, rate or extent of mesoderm development.


receptor localization to synapse

Any process in which a receptor is transported to, and/or maintained at the synapse, the junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell.


regulation of receptor localization to synapse

Any process that modulates the frequency, rate or extent of receptor localization to synapse.


GRIK1_MOUSE Glutamate receptor ionotropic, kainate 1 (sprot)

A glutamate receptor ionotropic, kainate 1 that is encoded in the genome of mouse.


Cul4A-RING E3 ubiquitin ligase complex

A ubiquitin ligase complex in which a cullin from the Cul4A subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by an adaptor protein.


Sucrose

A glycosyl glycoside formed by glucose and fructose units joined by an acetal oxygen bridge from hemiacetal of glucose to the hemiketal of the fructose.


Saccharin

A 1,2-benzisothiazole having a keto-group at the 3-position and two oxo substituents at the 1-position. It is used as an artificial sweetening agent.


GRM4_HUMAN Metabotropic glutamate receptor 4 (sprot)

A metabotropic glutamate receptor 4 that is encoded in the genome of human.


D-Tryptophan

The D-enantiomer of tryptophan.


mitogen-activated protein kinase 14 isoform 1 (mouse)

A mitogen-activated protein kinase 14 isoform 1 that is encoded in the genome of mouse.


protein phosphatase 1 binding

Binding to a protein phosphatase 1.


nuclear lamina

The fibrous, electron-dense layer lying on the nucleoplasmic side of the inner membrane of a cell nucleus, composed of lamin filaments. The polypeptides of the lamina are thought to be concerned in the dissolution of the nuclear envelope and its re-formation during mitosis. The lamina is composed of lamin A and lamin C filaments cross-linked into an orthogonal lattice, which is attached via lamin B to the inner nuclear membrane through interactions with a lamin B receptor, an IFAP, in the membrane.


A multilamellar subcellular structure formed in the cytoplasm of developing neuron, composed of Tmem240 and Emd proteins.


detection of wounding

The series of events by which an injury stimulus is received and converted into a molecular signal.


mesenchyme migration

The process in which the population of cells that make up a mesenchyme undergo directed movement.


right lung morphogenesis

The process in which anatomical structures of the right lung are generated and organized.


positive regulation of mitochondrial membrane potential

Any process that activates or increases the frequency, rate or extent of establishment or extent of a mitochondrial membrane potential, the electric potential existing across any mitochondrial membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane.


positive regulation of fibroblast apoptotic process

Any process that activates or increases the frequency, rate or extent of fibroblast apoptotic process.


mitochondrial outer membrane permeabilization

The process by which the mitochondrial outer membrane becomes permeable to the passing of proteins and other molecules from the intermembrane space to the cytosol as part of the apoptotic signaling pathway.


negative regulation of interleukin-13 production

Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-13 production.


positive regulation of nuclear-transcribed mRNA poly(A) tail shortening

Any process that increases the frequency, rate or extent of poly(A) tail shortening of a nuclear-transcribed mRNA. Poly(A) tail shortening is the decrease in length of the poly(A) tail of an mRNA from full length to an oligo(A) length.


selenocysteine biosynthetic process

The chemical reactions and pathways resulting in the formation of selenocysteine, an essential component of glutathione peroxidase and some other proteins.


regulation of exocyst assembly

Any process that modulates the frequency, rate or extent of exocyst assembly.


positive regulation of cGMP-mediated signaling

Any process that increases the rate, frequency or extent of cGMP-mediated signaling.


nucleotide biosynthetic process

The chemical reactions and pathways resulting in the formation of nucleotides, any nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the glycose moiety; may be mono-, di- or triphosphate; this definition includes cyclic-nucleotides (nucleoside cyclic phosphates).


thymidylate kinase activity

Catalysis of the reaction: ATP + thymidine 5'-phosphate = ADP + thymidine 5'-diphosphate.


dTDP biosynthetic process

The chemical reactions and pathways resulting in the formation of dTDP, deoxyribosylthymine diphosphate (2'-deoxyribosylthymine5'-diphosphate).


calmodulin-activated 3',5'-cyclic-GMP phosphodiesterase activity

Catalysis of the reactions: nucleoside 3',5'-cyclic GMP + H2O = GMP + H+; this activity is activated by binding to calcium-bound calmodulin.


positive regulation of Rho protein signal transduction

Any process that activates or increases the frequency, rate or extent of Rho protein signal transduction.


GDP-dissociation inhibitor activity

Prevents the dissociation of GDP from a GTPase, thereby preventing GTP from binding.


response to type II interferon

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interferon-gamma stimulus. Interferon-gamma is also known as type II interferon.


vasoactive intestinal polypeptide receptor activity

Combining with vasoactive intestinal polypeptide to initiate a change in cell activity.


negative regulation of cytokine production involved in immune response

Any process that stops, prevents, or reduces the frequency, rate, or extent of cytokine production contributing to an immune response.


glomerulus vasculature development

The biological process whose specific outcome is the progression of a glomerulus vasculature from an initial condition to its mature state. This process begins with the formation of the glomerulus vasculature and ends with the mature structure. The glomerulus vasculature is composed of the tubule structures that carry blood or lymph in the glomerulus.


regulation of macrophage migration inhibitory factor signaling pathway

Any process that modulates the frequency, rate or extent of macrophage migration inhibitory factor signaling pathway.


negative regulation of vascular permeability

Any process that reduces the extent to which blood vessels can be pervaded by fluid.


protein-N-terminal asparagine amidohydrolase activity

Catalysis of the reaction: N-terminal L-asparaginyl-[protein] + H+ + H2O = N-terminal L-aspartyl-[protein] + NH4+. This reaction is the deamidation of an N-terminal asparagine residue in a peptide or protein.


calcium-dependent phospholipid binding

Binding to a phospholipid, a class of lipids containing phosphoric acid as a mono- or diester, in the presence of calcium.


structural constituent of myelin sheath

The action of a molecule that contributes to the structural integrity of the myelin sheath of a nerve.


establishment of body hair planar orientation

Orientation of body hairs, projections from the surface of an organism, such that the hairs all point in a uniform direction along the surface.


hemolymphoid system

Anatomical cluster consisting of the hematopoietic system and the lymphoid system, or its analogs.


OTOF_DANRE Otoferlin (sprot)

An otoferlin that is encoded in the genome of zebrafish.


OTOF_MOUSE Otoferlin (sprot)

An otoferlin that is encoded in the genome of mouse.


TRML1_MOUSE Trem-like transcript 1 protein (sprot)

A trem-like transcript 1 protein that is encoded in the genome of mouse.


histamine-induced gastric acid secretion

The regulated release of gastric acid induced by the interaction of histamine with H2 type receptor receptors with subsequent activation of adenylate cyclase and elevation of intracellular cyclic AMP.


intracellular monoatomic anion homeostasis

A homeostatic process involved in the maintenance of a steady state level of monoatomic anions within a cell. Monatomic anions (also called simple anions) are anions consisting of exactly one atom.


LIGO1_HUMAN Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 (sprot)

A leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 that is encoded in the genome of human.


MAG_HUMAN Myelin-associated glycoprotein (sprot)

A myelin-associated glycoprotein that is encoded in the genome of human.


OMGP_HUMAN Oligodendrocyte-myelin glycoprotein (sprot)

An oligodendrocyte-myelin glycoprotein that is encoded in the genome of human.


RTN4_HUMAN Reticulon-4 (sprot)

A reticulon-4 that is encoded in the genome of human.


cerebellar layer

A cortical cell layer of the cerebellum. Examples: the granular (inner+outer) layer, molecular layer, Purkinje cell layer, and the ventricular layer of the embryo.


actin monomer binding

Binding to monomeric actin, also known as G-actin.


KIFC1_HUMAN Kinesin-like protein KIFC1 (sprot)

A kinesin-like protein KIFC1 that is encoded in the genome of human.


CENPE_HUMAN Centromere-associated protein E (sprot)

A centromere-associated protein E that is encoded in the genome of human.


KIF9_HUMAN Kinesin-like protein KIF9 (sprot)

A kinesin-like protein KIF9 that is encoded in the genome of human.


KIF15_HUMAN Kinesin-like protein KIF15 (sprot)

A kinesin-like protein KIF15 that is encoded in the genome of human.


KIFA3_HUMAN Kinesin-associated protein 3 (sprot)

A kinesin-associated protein 3 that is encoded in the genome of human.


KI18A_HUMAN Kinesin-like protein KIF18A (sprot)

A kinesin-like protein KIF18A that is encoded in the genome of human.


KIF28_HUMAN Kinesin-like protein KIF28P (sprot)

A protein that is a translation product of the KIF28P gene in human.


KIF2A_HUMAN Kinesin-like protein KIF2A (sprot)

A kinesin-like protein KIF2A that is encoded in the genome of human.


KIF3C_HUMAN Kinesin-like protein KIF3C (sprot)

A kinesin-like protein KIF3C that is encoded in the genome of human.


KIF3B_HUMAN Kinesin-like protein KIF3B (sprot)

A kinesin-like protein KIF3B that is encoded in the genome of human.


KIF1C_HUMAN Kinesin-like protein KIF1C (sprot)

A kinesin-like protein KIF1C that is encoded in the genome of human.


KIF1B_HUMAN Kinesin-like protein KIF1B (sprot)

A kinesin-like protein KIF1B that is encoded in the genome of human.


KI21B_HUMAN Kinesin-like protein KIF21B (sprot)

A kinesin-like protein KIF21B that is encoded in the genome of human.


KIF4A_HUMAN Chromosome-associated kinesin KIF4A (sprot)

A chromosome-associated kinesin KIF4A that is encoded in the genome of human.


KLC1_HUMAN Kinesin light chain 1 (sprot)

A kinesin light chain 1 that is encoded in the genome of human.


KIF1A_HUMAN Kinesin-like protein KIF1A (sprot)

A kinesin-like protein KIF1A that is encoded in the genome of human.


KIF22_HUMAN Kinesin-like protein KIF22 (sprot)

A kinesin-like protein KIF22 that is encoded in the genome of human.


KI26B_HUMAN Kinesin-like protein KIF26B (sprot)

A kinesin-like protein KIF26B that is encoded in the genome of human.


KIF19_HUMAN Kinesin-like protein KIF19 (sprot)

A kinesin-like protein KIF19 that is encoded in the genome of human.


KIF4B_HUMAN Chromosome-associated kinesin KIF4B (sprot)

A chromosome-associated kinesin KIF4B that is encoded in the genome of human.


Q66K46_HUMAN Kinesin-like protein (Fragment) (trembl)


KLC3_HUMAN Kinesin light chain 3 (sprot)

A kinesin light chain 3 that is encoded in the genome of human.


Q6PKD1_HUMAN Kinesin-like protein (Fragment) (trembl)


KIF6_HUMAN Kinesin-like protein KIF6 (sprot)

A kinesin-like protein KIF6 that is encoded in the genome of human.


KI21A_HUMAN Kinesin-like protein KIF21A (sprot)

A kinesin-like protein KIF21A that is encoded in the genome of human.


KIF27_HUMAN Kinesin-like protein KIF27 (sprot)

A kinesin-like protein KIF27 that is encoded in the genome of human.


KI18B_HUMAN Kinesin-like protein KIF18B (sprot)

A kinesin-like protein KIF18B that is encoded in the genome of human.


KIF2B_HUMAN Kinesin-like protein KIF2B (sprot)

A kinesin-like protein KIF2B that is encoded in the genome of human.


KIFC2_HUMAN Kinesin-like protein KIFC2 (sprot)

A kinesin-like protein KIFC2 that is encoded in the genome of human.


KIF12_HUMAN Kinesin-like protein KIF12 (sprot)

A kinesin-like protein KIF12 that is encoded in the genome of human.


KI16B_HUMAN Kinesin-like protein KIF16B (sprot)

A kinesin-like protein KIF16B that is encoded in the genome of human.


KI20B_HUMAN Kinesin-like protein KIF20B (sprot)

A kinesin-like protein KIF20B that is encoded in the genome of human.


KIF2C_HUMAN Kinesin-like protein KIF2C (sprot)

A kinesin-like protein KIF2C that is encoded in the genome of human.


KLC2_HUMAN Kinesin light chain 2 (sprot)

A kinesin light chain 2 that is encoded in the genome of human.


KI13B_HUMAN Kinesin-like protein KIF13B (sprot)

A kinesin-like protein KIF13B that is encoded in the genome of human.


KLC4_HUMAN Kinesin light chain 4 (sprot)

A kinesin light chain 4 that is encoded in the genome of human.


KIF25_HUMAN Kinesin-like protein KIF25 (sprot)

A kinesin-like protein KIF25 that is encoded in the genome of human.


KI26A_HUMAN Kinesin-like protein KIF26A (sprot)

A kinesin-like protein KIF26A that is encoded in the genome of human.


gamma-catenin binding

Binding to catenin complex gamma subunit.


ACBD6_HUMAN Acyl-CoA-binding domain-containing protein 6 (sprot)

An acyl-CoA-binding domain-containing protein 6 that is encoded in the genome of human.


ACBP_HUMAN Acyl-CoA-binding protein (sprot)

An acyl-CoA-binding protein that is encoded in the genome of human.


ACBD7_HUMAN Acyl-CoA-binding domain-containing protein 7 (sprot)

An acyl-CoA-binding domain-containing protein 7 that is encoded in the genome of human.


O89096_MOUSE Fibroblast growth factor (trembl)

A fibroblast growth factor 14 isoform 3 that is encoded in the genome of mouse.


oxidoreductase activity, acting on peroxide as acceptor

Catalysis of an oxidation-reduction (redox) reaction in which the peroxide group acts as a hydrogen or electron acceptor.


negative regulation of release of cytochrome c from mitochondria

Any process that decreases the rate, frequency or extent of release of cytochrome c from mitochondria, the process in which cytochrome c is enabled to move from the mitochondrial intermembrane space into the cytosol, which is an early step in apoptosis and leads to caspase activation.


acetylcholine-mediated vasodilation involved in regulation of systemic arterial blood pressure

The process in which acetylcholine signaling causes vasodilation, resulting in a change in blood pressure.


response to hyperoxia

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating increased oxygen tension.


detection of oxygen

The series of events in which an oxygen stimulus is received by a cell and converted into a molecular signal.


erythrophore differentiation

The process in which a relatively unspecialized cell acquires the specialized features of an erythrophore cell. Erythrophores are pigment cells derived from the neural crest. They contain pteridine and/or carotenoid pigments in structures called pterinosomes or erythrosomes. This gives them an orange to red appearance.


muscle alpha-actinin binding

Binding to muscle isoforms of actinin. Muscle alpha-actinin isoforms are found in skeletal and cardiac muscle and are localized to the Z-disc.


minus-end-directed microtubule motor activity

A motor activity that generates movement along a microtubule toward the minus end, driven by ATP hydrolysis.


negative regulation of neutrophil apoptotic process

Any process that stops, prevents, or reduces the frequency, rate, or extent of neutrophil apoptotic process.


positive regulation of RNA splicing

Any process that activates or increases the frequency, rate or extent of RNA splicing.


protein localization to cell leading edge

A process in which a protein is transported to, or maintained in, a location within a cell leading edge.


Modulates the activity of the enzyme 1-phosphatidylinositol-3-kinase activity.


8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity

Catalysis of the reaction: 8-oxo-7,8-dihydroguanosine triphosphate (8-oxo-GTP) + H2O = 8-oxo-7,8-dihydroguanosine diphosphate (8-oxo-GDP) + phosphate. 8-oxo-7,8-dihydroguanosine triphosphate (8-oxo-GTP) is the oxidised form of the free guanine nucleotide and can act as a potent mutagenic substrate for transcription.


negative regulation of single stranded viral RNA replication via double stranded DNA intermediate

Any process that stops, prevents, or reduces the frequency, rate or extent of single stranded viral RNA replication via double stranded DNA intermediate.


Mre11 complex

Trimeric protein complex that possesses endonuclease activity; involved in meiotic recombination, DNA repair and checkpoint signaling. In Saccharomyces cerevisiae, the complex comprises Mre11p, Rad50p, and Xrs2p; complexes identified in other species generally contain proteins orthologous to the Saccharomyces cerevisiae proteins.


serotonin binding

Binding to serotonin (5-hydroxytryptamine), a monoamine neurotransmitter occurring in the peripheral and central nervous systems, also having hormonal properties.


phospholipase C-activating serotonin receptor signaling pathway

biolink:Pathway biolink:BiologicalProcess biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:NamedThing biolink:OntologyClass biolink:Occurrent biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

A phospholipase C-activating receptor G protein-coupled receptor signaling pathway initiated by serotonin binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.


positive regulation of myeloid leukocyte differentiation

Any process that activates or increases the frequency, rate, or extent of myeloid leukocyte differentiation.


stabilization of membrane potential

The accomplishment of a non-fluctuating membrane potential, the electric potential existing across any membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane.


calcium-activated potassium channel subunit alpha-1 isoform 4 (mouse)

A calcium-activated potassium channel subunit alpha-1 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q08460-4.


calcium-activated potassium channel subunit alpha-1 isoform 1 (mouse)

A calcium-activated potassium channel subunit alpha-1 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q08460-1.


hemoglobin binding

Binding to hemoglobin, an oxygen carrying, conjugated protein containing four heme groups and globin.


ankyrin binding

Binding to ankyrin, a 200 kDa cytoskeletal protein that attaches other cytoskeletal proteins to integral membrane proteins.


negative regulation of urine volume

Any process that decreases the amount of urine excreted from the body over a unit of time.


plasma membrane phospholipid scrambling

The movement of a population of phospholipid molecules from one leaflet of the plasma membrane bilayer to the opposite leaflet, resulting in loss of lipid asymmetry and surface exposure of phosphatidylserine (PS) and phosphatidylethanolamine (PE).


pH elevation

Any process that increases the internal pH of an organism, part of an organism or a cell, measured by the concentration of the hydrogen ion.


ANK1_MOUSE Ankyrin-1 (sprot)

An ankyrin-1 that is encoded in the genome of mouse.


Catalysis of the movement of N-retinylidene-N-retinylphosphatidylethanolamine from the exoplasmic to the cytosolic leaftlet of a membrane, using energy from the hydrolysis of ATP.


superior vena cava morphogenesis

The process in which the anatomical structure of superior vena cava generated and organized. The superior vena cava is a blood vessel that transports blood from the upper body to the heart.


pulmonary vein morphogenesis

The process in which the anatomical structure of the pulmonary venous blood vessels are generated and organized. Pulmonary veins are blood vessels that transport blood from the lungs to the heart.


ornithine decarboxylase inhibitor activity

Binds to and stops, prevents or reduces the activity of ornithine decarboxylase.


susceptibility to natural killer cell mediated cytotoxicity

The process of causing a cell to become susceptible to natural killer cell mediated cytotoxicity.


natural killer cell lectin-like receptor binding

Binding to a lectin-like natural killer cell receptor.


positive regulation of endosome to plasma membrane protein transport

Any process that activates or increases the frequency, rate or extent of endosome to plasma membrane protein transport.


copper ion homeostasis

Any process involved in the maintenance of an internal steady state of copper ions within an organism or cell.


sorting endosome

A multivesicular body surrounded by and connected with multiple tubular compartments with associated vesicles.


very-low-density lipoprotein particle receptor activity

Combining with a very-low-density lipoprotein particle and delivering the very-low-density lipoprotein into the cell via endocytosis.


low-density lipoprotein particle binding

Binding to a low-density lipoprotein particle, a lipoprotein particle that is rich in cholesterol esters and low in triglycerides, is typically composed of APOB100 and APOE, and has a density of 1.02-1.06 g/ml and a diameter of between 20-25 nm.


spermine metabolic process

The chemical reactions and pathways involving spermine, a polybasic amine found in human sperm, in ribosomes and in some viruses, which is involved in nucleic acid packaging. Synthesis is regulated by ornithine decarboxylase which plays a key role in control of DNA replication.


negative regulation of lipopolysaccharide-mediated signaling pathway

Any process that stops, prevents, or reduces the frequency, rate or extent of signaling in response to detection of lipopolysaccharide.


regulation of hydrogen peroxide metabolic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving hydrogen peroxide.


Q3TJI3_MOUSE Ubiquitin thioesterase CYLD (trembl)

A ubiquitin carboxyl-terminal hydrolase CYLD (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q3TJI3.


positive regulation of ion transmembrane transporter activity

Any process that activates or increases the activity of an ion transporter.


diacylglycerol binding

Binding to a diacylglycerol, a diester of glycerol and two fatty acids.


response to pheromone

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pheromone stimulus.


inter-male aggressive behavior

Aggressive behavior based on competition between males of the same species over access to resources such as females, dominance, status, etc. and characterized by noise, threats, and is often less injurious.


mating behavior, sex discrimination

The behavior of individuals for the purpose of discriminating between the sexes, for the purpose of finding a suitable mating partner.


negative regulation of male mating behavior

Any process that stops, prevents or reduces the frequency, rate or extent of male mating behavior.


territorial aggressive behavior

Aggressive behavior performed in defence of a fixed area against intruders, typically conspecifics.


male germ-line stem cell population maintenance

The process by which an organism or tissue maintains a population of male germ-line stem cells.


nuclear body organization

A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of any of the extra-nucleolar nuclear domains usually visualized by confocal microscopy and fluorescent antibodies to specific proteins.


regulation of definitive erythrocyte differentiation

Any process that modulates the rate, frequency, or extent of definitive erythrocyte differentiation. Definitive erythrocyte differentiation occurs as part of the process of definitive hemopoiesis.


positive regulation of meiotic cell cycle

Any process that activates or increases the frequency, rate or extent of progression through the meiotic cell cycle.


proton-dependent oligopeptide secondary active transmembrane transporter activity

Enables the transfer of a oligopeptide from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by proton movement.


oligopeptide transport

The directed movement of oligopeptides into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Oligopeptides are molecules that contain a small number (2 to 20) of amino-acid residues connected by peptide linkages.


regulation of acetylcholine secretion, neurotransmission

Any process that modulates the frequency, rate or extent of the regulated release of acetylcholine.


musculoskeletal movement, spinal reflex action

Involuntary movement caused by the application of a stimulus to an organism and a subsequent movement. The signal processing of this movement takes place in the spinal cord.


rhythmic synaptic transmission

Any process involved in the generation of rhythmic, synchronous synaptic inputs in a neural circuit.


sigma non-opioid intracellular receptor 1 isoform 1 (mouse)

A sigma non-opioid intracellular receptor 1 isoform 1 that is encoded in the genome of mouse.


thyrotropin-releasing hormone activity

The action characteristic of thyrotropin-releasing hormone (TRH), a hormone released by the mammalian hypothalamus into the hypophyseal-portal circulation in response to neural and/or chemical stimuli. Upon receptor binding, TRH increases the secretion of thyroid-stimulating hormone by the anterior pituitary.


aromatic amino acid metabolic process

The chemical reactions and pathways involving aromatic amino acid family, amino acids with aromatic ring (phenylalanine, tyrosine, tryptophan).


positive regulation of microglial cell activation

Any process that activates or increases the frequency, rate or extent of microglial cell activation.


positive regulation of telomere maintenance via telomerase

Any process that activates or increases the frequency, rate or extent of the addition of telomeric repeats by telomerase.


SHQ1_HUMAN Protein SHQ1 homolog (sprot)

A protein SHQ1 that is encoded in the genome of human.


GAR1_HUMAN H/ACA ribonucleoprotein complex subunit 1 (sprot)

An H/ACA ribonucleoprotein complex subunit 1 that is encoded in the genome of human.


DKC1_HUMAN H/ACA ribonucleoprotein complex subunit DKC1 (sprot)

An H/ACA ribonucleoprotein complex catalytic subunit that is encoded in the genome of human.


TCAB1_HUMAN Telomerase Cajal body protein 1 (sprot)

A telomerase Cajal body protein 1 that is encoded in the genome of human.


NOP10_HUMAN H/ACA ribonucleoprotein complex subunit 3 (sprot)

An H/ACA ribonucleoprotein complex subunit 3 that is encoded in the genome of human.


NHP2_HUMAN H/ACA ribonucleoprotein complex subunit 2 (sprot)

An H/ACA ribonucleoprotein complex subunit 2 that is encoded in the genome of human.


netrin receptor activity

Combining with a netrin signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.


regulation of transcription by RNA polymerase I

Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase I.


1-Myristoyl-sn-glycerol 3-phosphate

A 1-acyl-sn-glycerol 3-phosphate having myristoyl (tetradecanoyl) as the 1-O-acyl group.


A 1-monoglyceride with tetradecanoyl (myristoyl) as the acyl group.


negative regulation of odontogenesis of dentin-containing tooth

Any process that stops, prevents, or reduces the frequency, rate or extent of the formation and development of teeth, the hard, bony appendages which are borne on the jaws, or on other bones in the walls of the mouth or pharynx.


A  3-acyl-sn-glycerol where arachidonoyl is the 3-acyl group.


G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential

A G protein-coupled neurotransmitter receptor activity, occurring in the postsynaptic membrane, involved in regulation of postsynaptic membrane potential.


G protein-coupled neurotransmitter receptor activity involved in regulation of presynaptic membrane potential

G protein-coupled neurotransmitter receptor activity, occurring in the presynaptic membrane, involved in regulation of presynaptic membrane potential.


MDGA1_HUMAN MAM domain-containing glycosylphosphatidylinositol anchor protein 1 (sprot)

A MAM domain-containing glycosylphosphatidylinositol anchor protein 1 that is encoded in the genome of human.


aryl hydrocarbon receptor complex

A protein complex that acts as an aryl hydrocarbon (Ah) receptor. Cytosolic and nuclear Ah receptor complexes have different subunit composition, but both contain the ligand-binding subunit AhR.


eukaryotic translation elongation factor 1 complex

A multisubunit nucleotide exchange complex that binds GTP and aminoacyl-tRNAs, and catalyzes their codon-dependent placement at the A-site of the ribosome. In humans, the complex is composed of four subunits, alpha, beta, delta and gamma.


dendrite regeneration

The regrowth of dendrites in response to their loss or damage.


type IV hypersensitivity

An inflammatory response driven by T cell recognition of processed soluble or cell-associated antigens leading to cytokine release and leukocyte activation.


glucose catabolic process

The chemical reactions and pathways resulting in the breakdown of glucose, the aldohexose gluco-hexose.


induction by virus of host apoptotic process

Any viral process that activates or increases the frequency, rate or extent of cell death by apoptotic process.


NOTO_HUMAN Homeobox protein notochord (sprot)

A homeobox protein notochord that is encoded in the genome of human.


FGF7_MOUSE Fibroblast growth factor 7 (sprot)

A fibroblast growth factor 7 that is encoded in the genome of mouse.


FGF22_MOUSE Fibroblast growth factor 22 (sprot)

A fibroblast growth factor 22 that is encoded in the genome of mouse.


FGF10_MOUSE Fibroblast growth factor 10 (sprot)

A fibroblast growth factor 10 that is encoded in the genome of mouse.


wound healing, spreading of cells

The migration of a cell along or through a wound gap that contributes to the reestablishment of a continuous surface.


Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform m2 Src-phosphorylated form (mouse)

An Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform m2 (mouse) that has been phosphorylated on Tyr residues within Src phosphorylation sites. Example: UniProtKB:Q9QWY8-2, Tyr-782, MOD:00048.


translation regulator activity

Any molecular function involved in the initiation, activation, perpetuation, repression or termination of polypeptide synthesis at the ribosome.


negative regulation of binding

Any process that stops or reduces the rate or extent of binding, the selective interaction of a molecule with one or more specific sites on another molecule.


negative regulation of bile acid biosynthetic process

Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of bile acids.


labyrinthine layer morphogenesis

The process in which the labyrinthine layer of the placenta is generated and organized.


carbon dioxide transport

The directed movement of carbon dioxide (CO2) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


nuclear androgen receptor binding

Binding to a nuclear androgen receptor.


negative regulation of bone trabecula formation

Any process that stops, prevents or reduces the frequency, rate or extent of bone trabecula formation.


FasL biosynthetic process

The chemical reactions and pathways resulting in the formation of fas ligand (FasL or CD95L), an antigen originally found to be expressed on the cell surface of activated human T-lymphocytes and B-lymphocytes and a variety of malignant human lymphoid cell lines.


positive regulation of synapse maturation

Any process that increases the extent of synapse maturation, the process that organizes a synapse so that it attains its fully functional state.


lymphocyte chemotaxis

The directed movement of a lymphocyte in response to an external stimulus.


urinary bladder smooth muscle contraction

A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the urinary bladder. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The urinary bladder is a musculomembranous sac along the urinary tract.


B cell negative selection

Any process leading to negative selection in B cells. Mechanisms of negative selection include anergy and deletion.


response to mycotoxin

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mycotoxin stimulus. A mycotoxin is a toxic chemical substance produced by fungi.


positive regulation of calcium ion transport into cytosol

Any process that increases the rate of the directed movement of calcium ions into the cytosol of a cell. The cytosol is that part of the cytoplasm that does not contain membranous or particulate subcellular components.


regulation of skeletal muscle contraction by calcium ion signaling

Any process that modulates the frequency, rate or extent of skeletal muscle contraction by changing the calcium ion signals that trigger contraction.


negative regulation of double-strand break repair via single-strand annealing

Any process that stops, prevents or reduces the frequency, rate or extent of double-strand break repair via single-strand annealing.


8-oxo-7,8-dihydroguanine DNA N-glycosylase activity

Catalysis of the removal of 8-oxo-7,8-dihydroguanine bases by cleaving the N-C1' glycosidic bond between the oxidized purine and the deoxyribose sugar.


oxidized base lesion DNA N-glycosylase activity

Catalysis of the removal of oxidized bases by cleaving the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apurinic/apyrimidinic (AP) site.


An oxopurine that is guanine which is substituted by an oxo group at position 8.


An azaspiro compound that is 1,3,6,8-tetraazaspiro[4.4]non-6-ene which is substituted by oxo groups at positions 2, 4, and 9. Both enantiomers are highly mutagenic products resulting from the oxidation of guanine and 8-oxo-7,8-dihydroguanine in DNA by reactive oxygen species.


Guanidinohydantoin

An imidazolidine-2,4-dione substituted by a guanidino group at position 5.


regulation of protein deacetylation

Any process that modulates the rate, frequency, or extent of protein deacetylation, the removal of an acetyl group from a protein amino acid. An acetyl group is CH3CO-, derived from acetic [ethanoic] acid.


creatine biosynthetic process

The chemical reactions and pathways resulting in the formation of creatine, N-[amino(imino)methyl]-N-methylglycine. Creatine is formed by a process beginning with amidino group transfer from L-arginine to glycine to form guanidinoacetate, followed by methyl group transfer from S-adenosyl-L-methionine to guanidinoacetate; it is then is phosphorylated to form a pool that stores high energy phosphate for the replenishment of ATP during periods of high, or fluctuating energy demand. In animals, most creatine is transported to and used in muscle.


negative regulation of integrin activation

Any process that stops, prevents, or reduces the frequency, rate, or extent of integrin activation.


regulation of sphingolipid mediated signaling pathway

Any process that modulates the frequency, rate or extent of sphingolipid signaling.


columnar/cuboidal epithelial cell development

The process whose specific outcome is the progression of a columnar/cuboidal epithelial cell over time, from its formation to the mature structure. A columnar/cuboidal epithelial cell is a cell usually found in a two dimensional sheet with a free surface. Columnar/cuboidal epithelial cells take on the shape of a column or cube.


formation of primary germ layer

The formation of the ectoderm, mesoderm and endoderm during gastrulation.


regulation of ERBB signaling pathway

Any process that modulates the frequency, rate or extent of ERBB signaling pathway.


Q3V365_MOUSE Kinesin-like protein (trembl)

A kinesin-like protein KIF17 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q3V365.


macrophage derived foam cell differentiation

The process in which a monocyte acquires the specialized features of a foam cell. A foam cell is a type of cell containing lipids in small vacuoles and typically seen in atherosclerotic lesions, as well as other conditions.


insemination

The introduction of semen or sperm into the genital tract of a female.


regulation of vascular associated smooth muscle contraction

Any process that increases the frequency, rate or extent of vascular smooth muscle contraction.


mitocytosis

A migrasome-mediated selective removal of damaged mitochondria process that maintains mitochondrion homeostasis in migrating cells.


isoprenoid catabolic process

The chemical reactions and pathways resulting in the breakdown of an isoprenoid compound, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues.


Tetracosanoic acid

A C24 straight-chain saturated fatty acid.


LCN1_HUMAN Lipocalin-1 (sprot)

A lipocalin-1 that is encoded in the genome of human.


LCN12_HUMAN Epididymal-specific lipocalin-12 (sprot)

An epididymal-specific lipocalin-12 that is encoded in the genome of human.


LCN15_HUMAN Lipocalin-15 (sprot)

A lipocalin-15 that is encoded in the genome of human.


LCN9_HUMAN Epididymal-specific lipocalin-9 (sprot)

An epididymal-specific lipocalin-9 that is encoded in the genome of human.


Arachidic Acid

A C20 striaght-chain saturated fatty acid which forms a minor constituent of peanut (L. arachis) and corn oils. Used as an organic thin film in the production of liquid crystals for a wide variety of technical applications.


TRAPP complex

A large complex that acts as a tethering factor involved in transporting vesicles from the ER through the Golgi to the plasma membrane. A TRAPP (transport protein particle) complex has a core set of proteins which are joined by specific subunits depending on the cellular component where a given TRAPP complex is active.


mitotic cohesin complex

A cohesin complex that mediates sister chromatid cohesion during mitosis; has a subunit composition distinct from that of the meiotic cohesin complex.


positive regulation of maintenance of meiotic sister chromatid cohesion, centromeric

Any process that activates or increases the frequency, rate or extent of maintenance of meiotic sister chromatid cohesion in the centromeric region.


plasma membrane bounded cell projection morphogenesis

The process in which the anatomical structures of a plasma membrane bounded cell projection are generated and organized.


podocyte foot

A cell projection of a podocyte (glomerular visceral epithelial cell) forming a foot-like structure projecting from a podocyte primary projection, that wraps around capillaries of a renal glomerulus. Adjacent feet (pedicels) interdigitate, leaving thin filtration slits between them, which are covered by slit diaphragms.


cyclin K-CDK12 complex

A protein complex consisting of cyclin Kand cyclin-dependent kinase 12 (CDK12). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner.


Dimethylarsinate

The arsenic oxoanion that is the conjugate base of dimethylarsinic acid.


Dihydrogen arsenite

An arsenite ion resulting from the removal of a proton from one of the hydroxy groups of arsenous acid.


Methyl(dioxido)arsane

An arsenic oxoanion obtained deprotonation of both arsenite OH groups of methylarsonous acid.


Dobutamine

A  catecholamine that is 4-(3-aminobutyl)phenol in which one of the hydrogens attached to the nitrogen is substituted by a 2-(3,4-dihydroxyphenyl)ethyl group. A beta1-adrenergic receptor agonist that has cardiac stimulant action without evoking vasoconstriction or tachycardia, it is used as the hydrochloride to increase the contractility of the heart in the management of acute heart failure.


Teniposide

A furonaphthodioxole that is a synthetic derivative of podophyllotoxin with anti-tumour activity; causes single- and double-stranded breaks in DNA and DNA-protein cross-links and prevents repair by topoisomerase II binding.


Carbidopa hydrate

The hydrate of 3-(3,4-dihydroxyphenyl)propanoic acid in which the hydrogens alpha- to the carboxyl group are substituted by hydrazinyl and methyl groups (S-configuration). Carbidopa is a dopa decarboxylase inhibitor, so prevents conversion of levodopa to dopamine. It has no antiparkinson activity by itself, but is used in the management of Parkinson's disease to reduce peripheral adverse effects of levodopa.


A racemate comprising equimolar amounts of (R)- and (S)-SKF 38393


Imatinib Mesylate

A methanesulfonate (mesylate) salt that is the monomesylate salt of imatinib. Used for treatment of chronic myelogenous leukemia and gastrointestinal stromal tumours.


Catechol

A  benzenediol comprising of a benzene core carrying two hydroxy substituents ortho to each other.


Methyldopa

A derivative of L-tyrosine having a methyl group at the alpha-position and an additional hydroxy group at the 3-position on the phenyl ring.


A methylcatechol having a single methyl substituent at the 4-position. It has been isolated from Picea abies.


Benserazide

A carbohydrazide that results from the formal condensation of the carboxy group of DL-serine with the primary amino group of 4-(hydrazinylmethyl)benzene-1,2,3-triol. An aromatic-L-amino-acid decarboxylase inhibitor (DOPA decarboxylase inhibitor) that does not enter the central nervous system, it is used as its hydrochloride salt as an adjunct to levodopa in the treatment of parkinsonism. By preventing the conversion of levodopa to dopamine in the periphery, it causes an increase in the amount of levodopa reaching the central nervous system and so reduces the required dose. Benserazide has no antiparkinson actions when given alone.


Aminopyrine

A  pyrazolone  that is 1,2-dihydro-3H-pyrazol-3-one substituted by a dimethylamino group at position 4, methyl groups at positions 1 and 5 and a phenyl group at position 2. It exhibits analgesic, anti-inflammatory, and antipyretic properties.


Adinazolam

A triazolo[4,3-a][1,4]benzodiazepine having a dimethylaminomethyl group at the 1-position, a phenyl group at the 6-position and a chloro substituent at the 8-position.


3,4-Dihydroxy-5-methoxybenzoic acid

A member of the class of benzoic acids that is gallic acid in which the phenolic hydroxy group at position 3 is converted into the corresponding methyl ether.


A member of the class of catechols that is benzene-1,2-diol substituted by a nitro group at position 4.It is the by-product of the hydroxylation of p-nitrophenol.


A chlorocatechol that is catechol substituted by a chloro group at position 4.


A tetrol composed of ethyleneglycol having a 3,4-dihydroxyphenyl group at the 1-position.


3,4-Dihydroxymandelic acid

A catechol that is the 3,4-dihydroxy derivative of mandelic acid; a metabolite of L-dopa.


Tetrachlorocatechol

A chlorocatechol that is catechol in which all of the hydrogens attached to the benzene ring are replaced by chlorines.


A dihydroxyacetophenone that is acetophenone carrying hydroxy groups at positions 3' and 4'.


A member of the class of catechols that is catechol in which a hydrogen that is ortho to one of the hydroxy groups has been replaced by a methoxy group. It displays agonistic activity against G protein-coupled receptor 35 (GPR35).


regulation of cell-substrate adhesion

Any process that modulates the frequency, rate or extent of cell-substrate adhesion. Cell-substrate adhesion is the attachment of a cell to the underlying substrate via adhesion molecules.


peroxisome targeting sequence binding

Binding to a peroxisomal targeting sequence, a sequence of amino acids within a protein that acts as a signal for the localization of a protein into the peroxisome.


protein targeting to peroxisome

The process of directing proteins towards the peroxisome, usually using signals contained within the protein.


histone H3K9me2 methyltransferase activity

Catalysis of the reaction: N6,N6-dimethyl-L-lysyl9-[histone H3] + S-adenosyl-L-methionine = H+ + N6,N6,N6-trimethyl-L-lysyl9-[histone H3] + S-adenosyl-L-homocysteine. This reaction is the addition of a single methyl group to the dimethylated lysine residue at position 9 of histone H3, producing histone H3K9me3.


clathrin binding

Binding to a clathrin heavy or light chain, the main components of the coat of coated vesicles and coated pits, and which also occurs in synaptic vesicles.


clathrin coat assembly

The process that results in the assembly of clathrin triskelia into the ordered structure known as a clathrin cage.


follicular dendritic cell differentiation

The process in which a relatively unspecialized precursor cell acquires the specialized features of a follicular dendritic cell.


pyrimidine dimer repair

The repair of UV-induced T-T, C-T and C-C dimers.


histone acetyltransferase KAT2A isoform 1 (mouse)

A histone acetyltransferase KAT2A isoform 1 that is encoded in the genome of mouse.


histone acetyltransferase KAT2B isoform 1 (mouse)

A histone acetyltransferase KAT2B isoform 1 that is encoded in the genome of mouse.


transcriptional adapter 3 isoform 1 (mouse)

A transcriptional adapter 3 isoform 1 that is encoded in the genome of mouse.


MAP3K12-binding inhibitory protein 1 isoform 1 (mouse)

A MAP3K12-binding inhibitory protein 1 isoform 1 that is encoded in the genome of mouse.


ZZ-type zinc finger-containing protein 3 isoform 1 (mouse)

A ZZ-type zinc finger-containing protein 3 isoform 1 that is encoded in the genome of mouse.


SAGA-associated factor 29 isoform 1 (mouse)

A SAGA-associated factor 29 isoform 1 that is encoded in the genome of mouse.


transcriptional adapter 2-alpha isoform 1 (mouse)

A transcriptional adapter 2-alpha isoform 1 that is encoded in the genome of mouse.


WD repeat-containing protein 5 isoform 1 (mouse)

A WD repeat-containing protein 5 isoform 1 that is encoded in the genome of mouse.


YEATS domain-containing protein 2 isoform 1 (mouse)

A YEATS domain-containing protein 2 isoform 1 that is encoded in the genome of mouse.


L-lysine transmembrane transporter activity

Enables the transfer of L-lysine from one side of a membrane to the other. L-lysine is 2,6-diaminohexanoic acid.


cationic amino acid transporter 2 isoform 1 (mouse)

A cationic amino acid transporter 2 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P18581-1.


calcitonin gene-related peptide receptor activity

Combining with a calcitonin gene-related polypeptide (CGRP) to initiate a change in cell activity.


trabecular meshwork development

The progression of the trabecular meshwork over time, from its formation to the mature structure. The trabecular meshwork is a fenestrated endothelial-like tissue situated at the intersection of the cornea and the iris. The trabecular meshwork provides drainage for the aqueous humor.


extrinsic component of membrane

The component of a membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region.


viral genome replication

Any process involved directly in viral genome replication, including viral nucleotide metabolism.


mitigation of host defenses by symbiont

A process by which an organism avoids or tolerates the effects of its host organism's defense response. The host defense response is mounted by the host in response to the presence of the organism. The host is defined as the larger of the organisms involved in a symbiotic interaction.


KR231_HUMAN Keratin-associated protein 23-1 (sprot)

A keratin-associated protein 23-1 that is encoded in the genome of human.


KRA97_HUMAN Keratin-associated protein 9-7 (sprot)

A keratin-associated protein 9-7 that is encoded in the genome of human.


KR161_HUMAN Keratin-associated protein 16-1 (sprot)

A keratin-associated protein 16-1 that is encoded in the genome of human.


KRA96_HUMAN Keratin-associated protein 9-6 (sprot)

A keratin-associated protein 9-6 that is encoded in the genome of human.


KR291_HUMAN Keratin-associated protein 29-1 (sprot)

A keratin-associated protein 29-1 that is encoded in the genome of human.


KRA91_HUMAN Keratin-associated protein 9-1 (sprot)

A keratin-associated protein 9-1 that is encoded in the genome of human.


KRT86_HUMAN Keratin, type II cuticular Hb6 (sprot)

A keratin, type II cuticular Hb6 that is encoded in the genome of human.


KRA58_HUMAN Keratin-associated protein 5-8 (sprot)

A keratin-associated protein 5-8 that is encoded in the genome of human.


KT33A_HUMAN Keratin, type I cuticular Ha3-I (sprot)

A keratin, type I cuticular Ha3-I that is encoded in the genome of human.


KRT34_HUMAN Keratin, type I cuticular Ha4 (sprot)

A keratin, type I cuticular Ha4 that is encoded in the genome of human.


KRT36_HUMAN Keratin, type I cuticular Ha6 (sprot)

A keratin, type I cuticular Ha6 that is encoded in the genome of human.


KRT37_HUMAN Keratin, type I cuticular Ha7 (sprot)

A keratin, type I cuticular Ha7 that is encoded in the genome of human.


KRT38_HUMAN Keratin, type I cuticular Ha8 (sprot)

A keratin, type I cuticular Ha8 that is encoded in the genome of human.


K2C75_HUMAN Keratin, type II cytoskeletal 75 (sprot)

A keratin, type II cytoskeletal 75 that is encoded in the genome of human.


K1C14_HUMAN Keratin, type I cytoskeletal 14 (sprot)

A keratin, type I cytoskeletal 14 that is encoded in the genome of human.


K2C6A_HUMAN Keratin, type II cytoskeletal 6A (sprot)

A keratin, type II cytoskeletal 6A that is encoded in the genome of human.


K2C6B_HUMAN Keratin, type II cytoskeletal 6B (sprot)

A keratin, type II cytoskeletal 6B that is encoded in the genome of human.


K1C18_HUMAN Keratin, type I cytoskeletal 18 (sprot)

A keratin, type I cytoskeletal 18 that is encoded in the genome of human.


K2C8_HUMAN Keratin, type II cytoskeletal 8 (sprot)

A keratin, type II cytoskeletal 8 that is encoded in the genome of human.


K1C19_HUMAN Keratin, type I cytoskeletal 19 (sprot)

A keratin, type I cytoskeletal 19 that is encoded in the genome of human.


K2C7_HUMAN Keratin, type II cytoskeletal 7 (sprot)

A keratin, type II cytoskeletal 7 that is encoded in the genome of human.


K1C16_HUMAN Keratin, type I cytoskeletal 16 (sprot)

A keratin, type I cytoskeletal 16 that is encoded in the genome of human.


KRA14_HUMAN Keratin-associated protein 1-4 (sprot)

A keratin-associated protein 1-4 that is encoded in the genome of human.


KRA23_HUMAN Keratin-associated protein 2-3 (sprot)

A keratin-associated protein 2-3 that is encoded in the genome of human.


K2C3_HUMAN Keratin, type II cytoskeletal 3 (sprot)

A keratin, type II cytoskeletal 3 that is encoded in the genome of human.


K1C10_HUMAN Keratin, type I cytoskeletal 10 (sprot)

A keratin, type I cytoskeletal 10 that is encoded in the genome of human.


K1C13_HUMAN Keratin, type I cytoskeletal 13 (sprot)

A keratin, type I cytoskeletal 13 that is encoded in the genome of human.


K2C5_HUMAN Keratin, type II cytoskeletal 5 (sprot)

A keratin, type II cytoskeletal 5 that is encoded in the genome of human.


K1C15_HUMAN Keratin, type I cytoskeletal 15 (sprot)

A keratin, type I cytoskeletal 15 that is encoded in the genome of human.


K2C4_HUMAN Keratin, type II cytoskeletal 4 (sprot)

A keratin, type II cytoskeletal 4 that is encoded in the genome of human.


KRA59_HUMAN Keratin-associated protein 5-9 (sprot)

A keratin-associated protein 5-9 that is encoded in the genome of human.


K1C9_HUMAN Keratin, type I cytoskeletal 9 (sprot)

A keratin, type I cytoskeletal 9 that is encoded in the genome of human.


K1C20_HUMAN Keratin, type I cytoskeletal 20 (sprot)

A keratin, type I cytoskeletal 20 that is encoded in the genome of human.


K22E_HUMAN Keratin, type II cytoskeletal 2 epidermal (sprot)

A keratin, type II cytoskeletal 2 epidermal that is encoded in the genome of human.


K2C6C_HUMAN Keratin, type II cytoskeletal 6C (sprot)

A keratin, type II cytoskeletal 6C that is encoded in the genome of human.


KR121_HUMAN Keratin-associated protein 12-1 (sprot)

A keratin-associated protein 12-1 that is encoded in the genome of human.


KR122_HUMAN Keratin-associated protein 12-2 (sprot)

A keratin-associated protein 12-2 that is encoded in the genome of human.


KR10A_HUMAN Keratin-associated protein 10-10 (sprot)

A keratin-associated protein 10-10 that is encoded in the genome of human.


KR123_HUMAN Keratin-associated protein 12-3 (sprot)

A keratin-associated protein 12-3 that is encoded in the genome of human.


KR124_HUMAN Keratin-associated protein 12-4 (sprot)

A keratin-associated protein 12-4 that is encoded in the genome of human.


KR101_HUMAN Keratin-associated protein 10-1 (sprot)

A keratin-associated protein 10-1 that is encoded in the genome of human.


KR102_HUMAN Keratin-associated protein 10-2 (sprot)

A keratin-associated protein 10-2 that is encoded in the genome of human.


KR103_HUMAN Keratin-associated protein 10-3 (sprot)

A keratin-associated protein 10-3 that is encoded in the genome of human.


KR105_HUMAN Keratin-associated protein 10-5 (sprot)

A keratin-associated protein 10-5 that is encoded in the genome of human.


KR106_HUMAN Keratin-associated protein 10-6 (sprot)

A keratin-associated protein 10-6 that is encoded in the genome of human.


KR104_HUMAN Keratin-associated protein 10-4 (sprot)

A keratin-associated protein 10-4 that is encoded in the genome of human.


KR107_HUMAN Keratin-associated protein 10-7 (sprot)

A keratin-associated protein 10-7 that is encoded in the genome of human.


KR108_HUMAN Keratin-associated protein 10-8 (sprot)

A keratin-associated protein 10-8 that is encoded in the genome of human.


KR109_HUMAN Keratin-associated protein 10-9 (sprot)

A keratin-associated protein 10-9 that is encoded in the genome of human.


KR10B_HUMAN Keratin-associated protein 10-11 (sprot)

A keratin-associated protein 10-11 that is encoded in the genome of human.


KR10C_HUMAN Keratin-associated protein 10-12 (sprot)

A keratin-associated protein 10-12 that is encoded in the genome of human.


KRT83_HUMAN Keratin, type II cuticular Hb3 (sprot)

A keratin, type II cuticular Hb3 that is encoded in the genome of human.


KRT85_HUMAN Keratin, type II cuticular Hb5 (sprot)

A keratin, type II cuticular Hb5 that is encoded in the genome of human.


K22O_HUMAN Keratin, type II cytoskeletal 2 oral (sprot)

A keratin, type II cytoskeletal 2 oral that is encoded in the genome of human.


K1C17_HUMAN Keratin, type I cytoskeletal 17 (sprot)

A keratin, type I cytoskeletal 17 that is encoded in the genome of human.


KRA11_HUMAN Keratin-associated protein 1-1 (sprot)

A keratin-associated protein 1-1 that is encoded in the genome of human.


KT33B_HUMAN Keratin, type I cuticular Ha3-II (sprot)

A keratin, type I cuticular Ha3-II that is encoded in the genome of human.


K1H2_HUMAN Keratin, type I cuticular Ha2 (sprot)

A keratin, type I cuticular Ha2 that is encoded in the genome of human.


KRT81_HUMAN Keratin, type II cuticular Hb1 (sprot)

A keratin, type II cuticular Hb1 that is encoded in the genome of human.


K2C72_HUMAN Keratin, type II cytoskeletal 72 (sprot)

A keratin, type II cytoskeletal 72 that is encoded in the genome of human.


K1H1_HUMAN Keratin, type I cuticular Ha1 (sprot)

A keratin, type I cuticular Ha1 that is encoded in the genome of human.


K1C24_HUMAN Keratin, type I cytoskeletal 24 (sprot)

A keratin, type I cytoskeletal 24 that is encoded in the genome of human.


KR251_HUMAN Keratin-associated protein 25-1 (sprot)

A keratin-associated protein 25-1 that is encoded in the genome of human.


KR213_HUMAN Keratin-associated protein 21-3 (sprot)

A keratin-associated protein 21-3 that is encoded in the genome of human.


KR192_HUMAN Keratin-associated protein 19-2 (sprot)

A primate-type keratin-associated protein 19-2 that is encoded in the genome of human.


KR198_HUMAN Keratin-associated protein 19-8 (sprot)

A keratin-associated protein 19-8 that is encoded in the genome of human.


KR211_HUMAN Keratin-associated protein 21-1 (sprot)

A keratin-associated protein 21-1 that is encoded in the genome of human.


KR212_HUMAN Keratin-associated protein 21-2 (sprot)

A keratin-associated protein 21-2 that is encoded in the genome of human.


KR202_HUMAN Keratin-associated protein 20-2 (sprot)

A keratin-associated protein 20-2 that is encoded in the genome of human.


KR201_HUMAN Keratin-associated protein 20-1 (sprot)

A keratin-associated protein 20-1 that is encoded in the genome of human.


KRA61_HUMAN Keratin-associated protein 6-1 (sprot)

A keratin-associated protein 6-1 that is encoded in the genome of human.


KRA62_HUMAN Keratin-associated protein 6-2 (sprot)

A keratin-associated protein 6-2 that is encoded in the genome of human.


KRA63_HUMAN Keratin-associated protein 6-3 (sprot)

A keratin-associated protein 6-3 that is encoded in the genome of human.


KR196_HUMAN Keratin-associated protein 19-6 (sprot)

A keratin-associated protein 19-6 that is encoded in the genome of human.


KR195_HUMAN Keratin-associated protein 19-5 (sprot)

A keratin-associated protein 19-5 that is encoded in the genome of human.


KR194_HUMAN Keratin-associated protein 19-4 (sprot)

A keratin-associated protein 19-4 that is encoded in the genome of human.


KR151_HUMAN Keratin-associated protein 15-1 (sprot)

A keratin-associated protein 15-1 that is encoded in the genome of human.


KR134_HUMAN Keratin-associated protein 13-4 (sprot)

A keratin-associated protein 13-4 that is encoded in the genome of human.


KR271_HUMAN Keratin-associated protein 27-1 (sprot)

A keratin-associated protein 27-1 that is encoded in the genome of human.


KR241_HUMAN Keratin-associated protein 24-1 (sprot)

A keratin-associated protein 24-1 that is encoded in the genome of human.


KR221_HUMAN Keratin-associated protein 22-1 (sprot)

A keratin-associated protein 22-1 that is encoded in the genome of human.


KR133_HUMAN Keratin-associated protein 13-3 (sprot)

A keratin-associated protein 13-3 that is encoded in the genome of human.


K2C71_HUMAN Keratin, type II cytoskeletal 71 (sprot)

A keratin, type II cytoskeletal 71 that is encoded in the genome of human.


KR197_HUMAN Keratin-associated protein 19-7 (sprot)

A keratin-associated protein 19-7 that is encoded in the genome of human.


KR132_HUMAN Keratin-associated protein 13-2 (sprot)

A keratin-associated protein 13-2 that is encoded in the genome of human.


K2C79_HUMAN Keratin, type II cytoskeletal 79 (sprot)

A keratin, type II cytoskeletal 79 that is encoded in the genome of human.


K1C40_HUMAN Keratin, type I cytoskeletal 40 (sprot)

A keratin, type I cytoskeletal 40 that is encoded in the genome of human.


K1C39_HUMAN Keratin, type I cytoskeletal 39 (sprot)

A keratin, type I cytoskeletal 39 that is encoded in the genome of human.


K2C80_HUMAN Keratin, type II cytoskeletal 80 (sprot)

A keratin, type II cytoskeletal 80 that is encoded in the genome of human.


KR511_HUMAN Keratin-associated protein 5-11 (sprot)

A keratin-associated protein 5-11 that is encoded in the genome of human.


KR510_HUMAN Keratin-associated protein 5-10 (sprot)

A keratin-associated protein 5-10 that is encoded in the genome of human.


KRA57_HUMAN Keratin-associated protein 5-7 (sprot)

A keratin-associated protein 5-7 that is encoded in the genome of human.


KRA56_HUMAN Keratin-associated protein 5-6 (sprot)

A keratin-associated protein 5-6 that is encoded in the genome of human.


KRA54_HUMAN Keratin-associated protein 5-4 (sprot)

A keratin-associated protein 5-4 that is encoded in the genome of human.


KRA53_HUMAN Keratin-associated protein 5-3 (sprot)

A keratin-associated protein 5-3 that is encoded in the genome of human.


KRA51_HUMAN Keratin-associated protein 5-1 (sprot)

A keratin-associated protein 5-1 that is encoded in the genome of human.


KR261_HUMAN Keratin-associated protein 26-1 (sprot)

A keratin-associated protein 26-1 that is encoded in the genome of human.


KRA55_HUMAN Keratin-associated protein 5-5 (sprot)

A keratin-associated protein 5-5 that is encoded in the genome of human.


KRA52_HUMAN Keratin-associated protein 5-2 (sprot)

A keratin-associated protein 5-2 that is encoded in the genome of human.


K2C74_HUMAN Keratin, type II cytoskeletal 74 (sprot)

A keratin, type II cytoskeletal 74 that is encoded in the genome of human.


K1C28_HUMAN Keratin, type I cytoskeletal 28 (sprot)

A keratin, type I cytoskeletal 28 that is encoded in the genome of human.


K1C27_HUMAN Keratin, type I cytoskeletal 27 (sprot)

A keratin, type I cytoskeletal 27 that is encoded in the genome of human.


K1C26_HUMAN Keratin, type I cytoskeletal 26 (sprot)

A keratin, type I cytoskeletal 26 that is encoded in the genome of human.


K1C25_HUMAN Keratin, type I cytoskeletal 25 (sprot)

A keratin, type I cytoskeletal 25 that is encoded in the genome of human.


KR193_HUMAN Keratin-associated protein 19-3 (sprot)

A keratin-associated protein 19-3 that is encoded in the genome of human.


K2C1B_HUMAN Keratin, type II cytoskeletal 1b (sprot)

A keratin, type II cytoskeletal 1b that is encoded in the genome of human.


K2C73_HUMAN Keratin, type II cytoskeletal 73 (sprot)

A keratin, type II cytoskeletal 73 that is encoded in the genome of human.


KR191_HUMAN Keratin-associated protein 19-1 (sprot)

A keratin-associated protein 19-1 that is encoded in the genome of human.


KR131_HUMAN Keratin-associated protein 13-1 (sprot)

A keratin-associated protein 13-1 that is encoded in the genome of human.


KR111_HUMAN Keratin-associated protein 11-1 (sprot)

A keratin-associated protein 11-1 that is encoded in the genome of human.


KRA81_HUMAN Keratin-associated protein 8-1 (sprot)

A keratin-associated protein 8-1 that is encoded in the genome of human.


KRA13_HUMAN Keratin-associated protein 1-3 (sprot)

A keratin-associated protein 1-3 that is encoded in the genome of human.


K2C78_HUMAN Keratin, type II cytoskeletal 78 (sprot)

A keratin, type II cytoskeletal 78 that is encoded in the genome of human.


KRT35_HUMAN Keratin, type I cuticular Ha5 (sprot)

A keratin, type I cuticular Ha5 that is encoded in the genome of human.


K1C12_HUMAN Keratin, type I cytoskeletal 12 (sprot)

A keratin, type I cytoskeletal 12 that is encoded in the genome of human.


KR171_HUMAN Keratin-associated protein 17-1 (sprot)

A keratin-associated protein 17-1 that is encoded in the genome of human.


KRA99_HUMAN Keratin-associated protein 9-9 (sprot)

A keratin-associated protein 9-9 that is encoded in the genome of human.


KRA98_HUMAN Keratin-associated protein 9-8 (sprot)

A keratin-associated protein 9-8 that is encoded in the genome of human.


KRA94_HUMAN Keratin-associated protein 9-4 (sprot)

A keratin-associated protein 9-4 that is encoded in the genome of human.


KRA93_HUMAN Keratin-associated protein 9-3 (sprot)

A keratin-associated protein 9-3 that is encoded in the genome of human.


KRA92_HUMAN Keratin-associated protein 9-2 (sprot)

A keratin-associated protein 9-2 that is encoded in the genome of human.


KRA46_HUMAN Keratin-associated protein 4-6 (sprot)

A keratin-associated protein 4-6 that is encoded in the genome of human.


KR411_HUMAN Keratin-associated protein 4-11 (sprot)

A keratin-associated protein 4-11 that is encoded in the genome of human.


KRA41_HUMAN Keratin-associated protein 4-1 (sprot)

A keratin-associated protein 4-1 that is encoded in the genome of human.


KRA49_HUMAN Keratin-associated protein 4-9 (sprot)

A keratin-associated protein 4-9 that is encoded in the genome of human.


KRA48_HUMAN Keratin-associated protein 4-8 (sprot)

A keratin-associated protein 4-8 that is encoded in the genome of human.


KRA47_HUMAN Keratin-associated protein 4-7 (sprot)

A keratin-associated protein 4-7 that is encoded in the genome of human.


KRA45_HUMAN Keratin-associated protein 4-5 (sprot)

A keratin-associated protein 4-5 that is encoded in the genome of human.


KRA44_HUMAN Keratin-associated protein 4-4 (sprot)

A keratin-associated protein 4-4 that is encoded in the genome of human.