neuroepithelial stem cell

The stem cell from which glial precursor cell arises from.


anterior neural tube closure

biolink:BiologicalProcess biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:NamedThing biolink:Occurrent biolink:OntologyClass biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

The step in the formation of the neural tube, where the paired anterior neural folds are brought together and fuse at the dorsal midline.


spinal cord motor neuron differentiation

The process in which neuroepithelial cells in the ventral neural tube acquire specialized structural and/or functional features of motor neurons. Motor neurons innervate an effector (muscle or glandular) tissue and are responsible for transmission of motor impulses from the brain to the periphery. Differentiation includes the processes involved in commitment of a cell to a specific fate.


membrane hyperpolarization

The process in which membrane potential increases with respect to its steady-state potential, usually from negative potential to a more negative potential. For example, during the repolarization phase of an action potential the membrane potential often becomes more negative or hyperpolarized before returning to the steady-state resting potential.


planar cell polarity pathway involved in neural tube closure

biolink:Pathway biolink:BiologicalProcess biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:NamedThing biolink:OntologyClass biolink:Occurrent biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

The series of molecular signals initiated by binding of a Wnt protein to a receptor on the surface of the target cell where activated receptors signal via downstream effectors that modulates the establishment of planar polarity contributing to neural tube closure.


basal protein localization

Any process in which a protein is transported to, or maintained in, basal regions of the cell.


regulation of protein maturation

Any process that modulates the frequency, rate or extent of protein maturation.


autonomic ganglion

biolink:AnatomicalEntity biolink:OrganismalEntity biolink:BiologicalEntity biolink:NamedThing biolink:PhysicalEssence biolink:SubjectOfInvestigation biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

Ganglion that has dendrites that form a junction between autonomic nerves originating from the central nervous system and autonomic nerves innervating their target organs in the periphery. There are two subtypes, sympathetic ganglion and parasympathetic ganglion.


parasympathetic nerve

A nerve that is part of a parasympathetic nervous system [Automatically generated definition].


glial cell apoptotic process

Any apoptotic process in a glial cell, a non-neuronal cell of the nervous system.


vitamin metabolic process

The chemical reactions and pathways involving vitamins. Vitamin is a general term for a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body. Vitamins may be water-soluble or fat-soluble and usually serve as components of coenzyme systems.


acetylcholine metabolic process

The chemical reactions and pathways involving acetylcholine, the acetic acid ester of the organic base choline. Acetylcholine is a major neurotransmitter and neuromodulator both in the central and peripheral nervous systems. It also acts as a paracrine signal in various non-neural tissues.


corticospinal neuron axon guidance

The process in which the migration of an axon growth cone of a neuron that is part of the corticospinal tract is directed from the cerebral cortex layer V to the spinal cord dorsal funiculus in response to a combination of attractive and repulsive cues.


establishment of left/right asymmetry

The initial formation of the type asymmetry in an organism's body plan or part of an organism with respect to the left and right halves.


negative regulation of cyclin-dependent protein serine/threonine kinase activity

Any process that stops, prevents, or reduces the frequency, rate or extent of cyclin-dependent protein serine/threonine kinase activity.


response to UV

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ultraviolet radiation (UV light) stimulus. Ultraviolet radiation is electromagnetic radiation with a wavelength in the range of 10 to 380 nanometers.


negative regulation of B cell proliferation

Any process that stops, prevents or reduces the rate or extent of B cell proliferation.


negative regulation of activated T cell proliferation

Any process that stops, prevents or reduces the rate or extent of activated T cell proliferation.


metamorphosis

A biological process in which an animal physically develops after birth or hatching, involving a conspicuous and relatively abrupt change in the animal's form or structure. Examples include the change from tadpole to frog, and the change from larva to adult. An example of this is found in Drosophila melanogaster.


notochord regression

The developmental process in which the stucture of the notochord is destroyed in an embryo.


tendon formation

The process that gives rise to a tendon. This process pertains to the initial formation of a tendon from unspecified parts.


face development

The biological process whose specific outcome is the progression of a face from an initial condition to its mature state. The face is the ventral division of the head.


respiratory tube development

The process whose specific outcome is the progression of the respiratory tube over time, from its formation to the mature structure. The respiratory tube is assumed to mean any tube in the respiratory tract.


epithelial cell morphogenesis involved in placental branching

The change in form (cell shape and size) that occurs when a trophoblast cell elongates to contribute to the branching of the placenta.


lung lobe morphogenesis

The process in which the anatomical structures of a lung lobe are generated and organized. A lung lobe is a projection that extends from the lung.


cellular localization

A cellular localization process whereby a substance or cellular entity, such as a protein complex or organelle, is transported to, and/or maintained in, a specific location within a cell including the localization of substances or cellular entities to the cell membrane.


response to cadmium ion

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cadmium (Cd) ion stimulus.


LDH6B_HUMAN L-lactate dehydrogenase A-like 6B (sprot)

An L-lactate dehydrogenase A-like 6B that is encoded in the genome of human.


negative regulation of retinoic acid receptor signaling pathway

Any process that stops, prevents, or reduces the frequency, rate or extent of retinoic acid receptor signaling pathway activity.


meiotic cell cycle phase

One of the distinct periods or stages into which the meiotic cell cycle is divided. Each phase is characterized by the occurrence of specific biochemical and morphological events.


NOLC1_HUMAN Nucleolar and coiled-body phosphoprotein 1 (sprot)

A nucleolar phosphoprotein p130 that is encoded in the genome of human.


sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform mSERCA3B (mouse)

A sarcoplasmic/endoplasmic reticulum calcium ATPase 3 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q64518-1.


sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform SERCA3A (mouse)

A sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform 2 that is encoded in the genome of mouse.


sarcoplasmic/endoplasmic reticulum calcium ATPase 2 isoform 2 (mouse)

A sarcoplasmic/endoplasmic reticulum calcium ATPase 2 isoform 2 that is encoded in the genome of mouse.


Rab geranylgeranyltransferase activity

biolink:MolecularActivity biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:NamedThing biolink:Occurrent biolink:OntologyClass biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

Catalysis of the reaction: 2 geranylgeranyl diphosphate + protein-cysteine = 2 S-geranylgeranyl-protein + 2 diphosphate. This reaction is the formation of two thioether linkages between the C-1 atom of the geranylgeranyl groups and two cysteine residues within the terminal sequence motifs XXCC, XCXC or CCXX. Known substrates include Ras-related GTPases of a single family and the Rab family.


IBP1_HUMAN Insulin-like growth factor-binding protein 1 (sprot)

An insulin-like growth factor-binding protein 1 that is encoded in the genome of human.


HERP1_HUMAN Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein (sprot)

A homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein that is encoded in the genome of human.


glyceryl-ether monooxygenase activity

Catalysis of the reaction: 1-alkyl-sn-glycerol + O2 + (tetrahydrobiopterin/tetrahydropteridine) = 1-hydroxyalkyl-sn-glycerol + H2O + (dihydrobiopterin/dihydropteridine).


cardiolipin synthase (CMP-forming)

Catalysis of the reaction: CDP-diacylglycerol + phosphatidylglycerol = CMP + diphosphatidylglycerol.


phosphatidylserine biosynthetic process

The chemical reactions and pathways resulting in the formation of phosphatidylserines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of L-serine.


rRNA modification

The covalent alteration of one or more nucleotides within an rRNA molecule to produce an rRNA molecule with a sequence that differs from that coded genetically.


epidermal growth factor receptor ligand maturation

Any process leading to the attainment of the full functional capacity of a ligand for an epidermal growth factor receptor. The ligand is functional when it can bind to and activate an epidermal growth factor receptor.


signaling receptor ligand precursor processing

The cleavage of a peptide bond in a precursor form of a signaling receptor ligand, resulting in the mature (active) form of the ligand.


EGF_MOUSE Pro-epidermal growth factor (sprot)

A pro-epidermal growth factor that is encoded in the genome of mouse.


EPHA1_HUMAN Ephrin type-A receptor 1 (sprot)

An ephrin type-A receptor 1 that is encoded in the genome of human.


EFNA2_HUMAN Ephrin-A2 (sprot)

An ephrin-A2 that is encoded in the genome of human.


EFNA1_HUMAN Ephrin-A1 (sprot)

An ephrin-A1 that is encoded in the genome of human.


EPHA2_HUMAN Ephrin type-A receptor 2 (sprot)

An ephrin type-A receptor 2 that is encoded in the genome of human.


EPHA3_HUMAN Ephrin type-A receptor 3 (sprot)

An ephrin type-A receptor 3 that is encoded in the genome of human.


EPHA8_HUMAN Ephrin type-A receptor 8 (sprot)

An ephrin type-A receptor 8 that is encoded in the genome of human.


EFNA3_HUMAN Ephrin-A3 (sprot)

An ephrin-A3 that is encoded in the genome of human.


EFNA4_HUMAN Ephrin-A4 (sprot)

An ephrin-A4 that is encoded in the genome of human.


EFNA5_HUMAN Ephrin-A5 (sprot)

An ephrin-A5 that is encoded in the genome of human.


EPHA5_HUMAN Ephrin type-A receptor 5 (sprot)

An ephrin type-A receptor 5 that is encoded in the genome of human.


EPHA7_HUMAN Ephrin type-A receptor 7 (sprot)

An ephrin type-A receptor 7 that is encoded in the genome of human.


EPHAA_HUMAN Ephrin type-A receptor 10 (sprot)

An ephrin type-A receptor 10 that is encoded in the genome of human.


EPHA6_HUMAN Ephrin type-A receptor 6 (sprot)

An ephrin type-A receptor 6 that is encoded in the genome of human.


free ubiquitin chain polymerization

The process of creating free ubiquitin chains, compounds composed of a large number of ubiquitin monomers. These chains are not conjugated to a protein.


protein K27-linked ubiquitination

A protein ubiquitination process in which a polymer of ubiquitin, formed by linkages between lysine residues at position 27 of the ubiquitin monomers, is added to a protein.


protein monoubiquitination

Addition of a single ubiquitin group to a protein.


proteasomal protein catabolic process

The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds that is mediated by the proteasome.


negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway

Any process that stops, prevents, or reduces the frequency, rate, or extent of the nucleotide-binding oligomerization domain containing 2 (NOD2) pathway.


protein import into peroxisome matrix, receptor recycling

The process in which peroxisome targeting sequence receptors dissociates from cargo proteins and are returned to the cytosol.


protein import into peroxisome matrix, substrate release

The process by which the cargo protein is released into the peroxisomal matrix, following translocation across the membrane.


positive regulation of toll-like receptor 3 signaling pathway

Any process that activates or increases the frequency, rate, or extent of toll-like receptor 3 signaling pathway.


positive regulation of defense response to virus by host

Any host process that results in the promotion of antiviral immune response mechanisms, thereby limiting viral replication.


negative regulation of defense response to virus by host

Any host process that results in the inhibition of antiviral immune response mechanisms, thereby facilitating viral replication. The host is defined as the larger of the organisms involved in a symbiotic interaction.


protein K11-linked ubiquitination

A protein ubiquitination process in which ubiquitin monomers are attached to a protein, and then ubiquitin polymers are formed by linkages between lysine residues at position 11 of the ubiquitin monomers. K11-linked polyubiquitination targets the substrate protein for degradation. The anaphase-promoting complex promotes the degradation of mitotic regulators by assembling K11-linked polyubiquitin chains.


stress granule disassembly

The disaggregation of a stress granule into its constituent protein and RNA parts.


positive regulation of toll-like receptor 4 signaling pathway

Any process that activates or increases the frequency, rate, or extent of toll-like receptor 4 signaling pathway.


negative regulation of toll-like receptor 3 signaling pathway

Any process that stops, prevents, or reduces the frequency, rate, or extent of toll-like receptor 3 signaling pathway.


negative regulation of response to oxidative stress

Any process that stops, prevents or reduces the frequency, rate or extent of response to oxidative stress.


translation elongation factor activity

Functions in chain elongation during polypeptide synthesis at the ribosome.


translation release factor activity

Involved in catalyzing the release of a nascent polypeptide chain from a ribosome.


biolink:CellularComponent biolink:AnatomicalEntity biolink:OrganismalEntity biolink:BiologicalEntity biolink:NamedThing biolink:PhysicalEssence biolink:SubjectOfInvestigation biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.


ubiquitin

A proteolytic cleavage product that gives rise to a protein that corresponds to the stand-alone version of the Ubiquitin (Pfam:PF00240) domain. Example: UniProtKB:P0CG48, 1-76.


RS20_HUMAN Small ribosomal subunit protein uS10 (sprot)

A 40S ribosomal protein S20 that is encoded in the genome of human.


G3BP1_HUMAN Ras GTPase-activating protein-binding protein 1 (sprot)

A Ras GTPase-activating protein-binding protein 1 that is encoded in the genome of human.


RS3_HUMAN Small ribosomal subunit protein uS3 (sprot)

A 40S ribosomal protein S3 that is encoded in the genome of human.


Toll-like receptor 3 isoform h1 (human)

A Toll-like receptor 3 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O15455-1.


RAB1A_HUMAN Ras-related protein Rab-1A (sprot)

A Ras-related protein Rab-1A that is encoded in the genome of human.


biolink:MacromolecularComplex biolink:BiologicalEntity biolink:NamedThing biolink:MacromolecularMachineMixin biolink:ThingWithTaxon


BIRC5_HUMAN Baculoviral IAP repeat-containing protein 5 (sprot)

A baculoviral IAP repeat-containing protein 5 that is encoded in the genome of human.


ELOB_HUMAN Elongin-B (sprot)

An elongin-B that is encoded in the genome of human.


ELOC_HUMAN Elongin-C (sprot)

An elongin-C that is encoded in the genome of human.


SHPRH_HUMAN E3 ubiquitin-protein ligase SHPRH (sprot)

An E3 ubiquitin-protein ligase SHPRH that is encoded in the genome of human.


RN181_HUMAN E3 ubiquitin-protein ligase RNF181 (sprot)

An E3 ubiquitin-protein ligase RNF181 that is encoded in the genome of human.


HLTF_HUMAN Helicase-like transcription factor (sprot)

A helicase-like transcription factor that is encoded in the genome of human.


WAC_HUMAN WW domain-containing adapter protein with coiled-coil (sprot)

A WW domain-containing adapter protein with coiled-coil that is encoded in the genome of human.


ubiquitin-conjugating enzyme E2 J2 isoform h1 (human)

A ubiquitin-conjugating enzyme E2 J2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q8N2K1-1.


US11_HCMVA Unique short US11 glycoprotein (sprot)


BACH1_HUMAN Transcription regulator protein BACH1 (sprot)

A transcription regulator protein BACH1 that is encoded in the genome of human.


FXL17_HUMAN F-box/LRR-repeat protein 17 (sprot)

An F-box/LRR-repeat protein 17 that is encoded in the genome of human.


H2B1K_HUMAN Histone H2B type 1-K (sprot)

A histone H2B type 1-K that is encoded in the genome of human.


H2B1J_HUMAN Histone H2B type 1-J (sprot)

A histone H2B type 1-J that is encoded in the genome of human.


H2B1O_HUMAN Histone H2B type 1-O (sprot)

A histone H2B type 1-O that is encoded in the genome of human.


H2B1B_HUMAN Histone H2B type 1-B (sprot)

A histone H2B type 1-B that is encoded in the genome of human.


H2B1D_HUMAN Histone H2B type 1-D (sprot)

A histone H2B type 1-D that is encoded in the genome of human.


H2B1C_HUMAN Histone H2B type 1-C/E/F/G/I (sprot)

A histone H2B type 1-C/E/F/G/I that is encoded in the genome of human.


H2B1H_HUMAN Histone H2B type 1-H (sprot)

A histone H2B type 1-H that is encoded in the genome of human.


H2B1A_HUMAN Histone H2B type 1-A (sprot)

A histone H2B type 1-A that is encoded in the genome of human.


H2B1N_HUMAN Histone H2B type 1-N (sprot)

A histone H2B type 1-N that is encoded in the genome of human.


H2B1M_HUMAN Histone H2B type 1-M (sprot)

A histone H2B type 1-M that is encoded in the genome of human.


H2B1L_HUMAN Histone H2B type 1-L (sprot)

A histone H2B type 1-L that is encoded in the genome of human.


Q9MY60_HUMAN MHC Class I antigen (B60) (Fragment) (trembl)


RNF10_HUMAN E3 ubiquitin-protein ligase RNF10 (sprot)

A RING finger protein 10 that is encoded in the genome of human.


BRAP_HUMAN BRCA1-associated protein (sprot)

A BRCA1-associated protein that is encoded in the genome of human.


TM129_HUMAN E3 ubiquitin-protein ligase TM129 (sprot)

An E3 ubiquitin-protein ligase TM129 that is encoded in the genome of human.


RFFL_HUMAN E3 ubiquitin-protein ligase rififylin (sprot)

An E3 ubiquitin-protein ligase rififylin that is encoded in the genome of human.


ASCC3_HUMAN Activating signal cointegrator 1 complex subunit 3 (sprot)

An activating signal cointegrator 1 complex subunit 3 that is encoded in the genome of human.


ABCE1_HUMAN ATP-binding cassette sub-family E member 1 (sprot)

An ATP-binding cassette sub-family E member 1 that is encoded in the genome of human.


endonucleolytic cleavage in ITS1 upstream of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

Endonucleolytic cleavage within Internal Transcribed Spacer 1 (ITS1) upstream of the 5.8S rRNA derived from an originally tricistronic rRNA transcript that contained the Small Subunit (SSU) rRNA, the 5.8S rRNA, and the Large Subunit (LSU) rRNA in that order from 5' to 3' along the primary transcript. In S. cerevisiae, this endonucleolytic cleavage within ITS1 initiates the maturation of the LSU and the 5.8S rRNAs.


PPIL2_HUMAN RING-type E3 ubiquitin-protein ligase PPIL2 (sprot)

A RING-type E3 ubiquitin-protein ligase PPIL2 that is encoded in the genome of human.


YJU2_HUMAN Splicing factor YJU2 (sprot)

A splicing factor YJU2 that is encoded in the genome of human.


REN3B_HUMAN Regulator of nonsense transcripts 3B (sprot)

A regulator of nonsense transcripts 3B that is encoded in the genome of human.


PQBP1_HUMAN Polyglutamine-binding protein 1 (sprot)

A polyglutamine-binding protein 1 that is encoded in the genome of human.


CWC27_HUMAN Spliceosome-associated protein CWC27 homolog (sprot)

A spliceosome-associated protein CWC27 homolog that is encoded in the genome of human.


GPKOW_HUMAN G-patch domain and KOW motifs-containing protein (sprot)

A G-patch domain and KOW motifs-containing protein that is encoded in the genome of human.


R113A_HUMAN E3 ubiquitin-protein ligase RNF113A (sprot)

An E3 ubiquitin-protein ligase RNF113A that is encoded in the genome of human.


WDR70_HUMAN WD repeat-containing protein 70 (sprot)

A WD repeat-containing protein 70 that is encoded in the genome of human.


CASC3_HUMAN Protein CASC3 (sprot)

A protein CASC3 that is encoded in the genome of human.


CWC25_HUMAN Pre-mRNA-splicing factor CWC25 homolog (sprot)

A pre-mRNA-splicing factor CWC25 homolog that is encoded in the genome of human.


DHX35_HUMAN Probable ATP-dependent RNA helicase DHX35 (sprot)

A probable ATP-dependent RNA helicase DHX35 that is encoded in the genome of human.


MFAP1_HUMAN Microfibrillar-associated protein 1 (sprot)

A microfibrillar-associated protein 1 that is encoded in the genome of human.


PPIL4_HUMAN Peptidyl-prolyl cis-trans isomerase-like 4 (sprot)

A peptidyl-prolyl cis-trans isomerase-like 4 that is encoded in the genome of human.


GPTC1_HUMAN G patch domain-containing protein 1 (sprot)

A G patch domain-containing protein 1 that is encoded in the genome of human.


NSRP1_HUMAN Nuclear speckle splicing regulatory protein 1 (sprot)

A nuclear speckle splicing regulatory protein 1 that is encoded in the genome of human.


PP1R8_HUMAN Nuclear inhibitor of protein phosphatase 1 (sprot)

A nuclear inhibitor of protein phosphatase 1 that is encoded in the genome of human.


TCRG1_HUMAN Transcription elongation regulator 1 (sprot)

A transcription elongation regulator 1 that is encoded in the genome of human.


UBL5_HUMAN Ubiquitin-like protein 5 (sprot)

A ubiquitin-like protein 5 that is encoded in the genome of human.


RBM5_HUMAN RNA-binding protein 5 (sprot)

An RNA-binding protein 5 that is encoded in the genome of human.


DNJC8_HUMAN DnaJ homolog subfamily C member 8 (sprot)

A DnaJ homolog subfamily C member 8 that is encoded in the genome of human.


PRP18_HUMAN Pre-mRNA-splicing factor 18 (sprot)

A pre-mRNA-splicing factor 18 that is encoded in the genome of human.


PR38A_HUMAN Pre-mRNA-splicing factor 38A (sprot)

A pre-mRNA-splicing factor 38A that is encoded in the genome of human.


WBP4_HUMAN WW domain-binding protein 4 (sprot)

A WW domain-binding protein 4 that is encoded in the genome of human.


WBP11_HUMAN WW domain-binding protein 11 (sprot)

A WW domain-binding protein 11 that is encoded in the genome of human.


CCAR1_HUMAN Cell division cycle and apoptosis regulator protein 1 (sprot)

A cell division cycle and apoptosis regulator protein 1 that is encoded in the genome of human.


IF4A3_HUMAN Eukaryotic initiation factor 4A-III (sprot)

A eukaryotic initiation factor 4A-III that is encoded in the genome of human.


ZMAT2_HUMAN Zinc finger matrin-type protein 2 (sprot)

A zinc finger matrin-type protein 2 that is encoded in the genome of human.


DHX9_HUMAN ATP-dependent RNA helicase A (sprot)

An ATP-dependent RNA helicase A that is encoded in the genome of human.


RBM39_HUMAN RNA-binding protein 39 (sprot)

An RNA-binding protein 39 that is encoded in the genome of human.


SMU1_HUMAN WD40 repeat-containing protein SMU1 (sprot)

A WD40 repeat-containing protein SMU1 that is encoded in the genome of human.


PR40A_HUMAN Pre-mRNA-processing factor 40 homolog A (sprot)

A pre-mRNA-processing factor 40 homolog A that is encoded in the genome of human.


PRP4B_HUMAN Serine/threonine-protein kinase PRP4 homolog (sprot)

A serine/threonine-protein kinase PRP4 that is encoded in the genome of human.


RED_HUMAN Protein Red (sprot)

A protein Red that is encoded in the genome of human.


SNUT1_HUMAN U4/U6.U5 tri-snRNP-associated protein 1 (sprot)

A U4/U6.U5 tri-snRNP-associated protein 1 that is encoded in the genome of human.


SF01_HUMAN Splicing factor 1 (sprot)

A splicing factor 1 that is encoded in the genome of human.


RBM42_HUMAN RNA-binding protein 42 (sprot)

An RNA-binding protein 42 that is encoded in the genome of human.


RBM7_HUMAN RNA-binding protein 7 (sprot)

An RNA-binding protein 7 that is encoded in the genome of human.


LC7L3_HUMAN Luc7-like protein 3 (sprot)

A cisplatin resistance-associated overexpressed protein that is encoded in the genome of human.


RBM25_HUMAN RNA-binding protein 25 (sprot)

An RNA-binding protein 25 that is encoded in the genome of human.


UBP39_HUMAN Ubiquitin carboxyl-terminal hydrolase 39 (sprot)

A U4/U6.U5 tri-snRNP-associated protein 2 that is encoded in the genome of human.


TXN4A_HUMAN Thioredoxin-like protein 4A (sprot)

A thioredoxin-like protein 4A that is encoded in the genome of human.


PRP6_HUMAN Pre-mRNA-processing factor 6 (sprot)

A pre-mRNA-processing factor 6 that is encoded in the genome of human.


SNR27_HUMAN U4/U6.U5 small nuclear ribonucleoprotein 27 kDa protein (sprot)

A U4/U6.U5 small nuclear ribonucleoprotein 27 kDa protein that is encoded in the genome of human.


post-transcriptional regulation of gene expression

Any process that modulates the frequency, rate or extent of gene expression after the production of an RNA transcript.


regulation of Golgi organization

Any process that modulates the frequency, rate or extent of Golgi organization.


protein localization to Golgi membrane

A process in which a protein is transported to, or maintained in, a location within a Golgi membrane.


mitochondrion inheritance

The distribution of mitochondria, including the mitochondrial genome, into daughter cells after mitosis or meiosis, mediated by interactions between mitochondria and the cytoskeleton.


endoplasmic reticulum inheritance

The partitioning of endoplasmic reticulum between daughter cells at cell division.


Golgi inheritance

The partitioning of Golgi apparatus between daughter cells at cell division.


Golgi distribution to daughter cells

Any process in which disassembled Golgi vesicles are localized into daughter cells upon cell division.


regulation of carbohydrate metabolic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving carbohydrates.


cytolysis in another organism

The killing by an organism of a cell in another organism by means of the rupture of cell membranes and the loss of cytoplasm.


adenylate cyclase-modulating G protein-coupled receptor signaling pathway

A G protein-coupled receptor signaling pathway in which the signal is transmitted via the activation or inhibition of adenylyl cyclase activity and a subsequent change in the intracellular concentration of cyclic AMP (cAMP).


Golgi to plasma membrane transport

The directed movement of substances from the Golgi to the plasma membrane in transport vesicles that move from the trans-Golgi network to the plasma membrane, where they fuse and release their contents by exocytosis.


NAD-dependent protein depalmitoylase activity

Catalysis of the reaction: N6-octadecanoyl-L-lysyl-[protein] + NAD+ + H2O = octadecanoyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide.


3'-5' RNA helicase activity

Unwinding of an RNA helix in the 3' to 5' direction, driven by ATP hydrolysis.


negative regulation of GTPase activity

Any process that stops or reduces the rate of GTP hydrolysis by a GTPase.


Catalysis of the reaction: 10-formyltetrahydrofolate + L-methionyl-tRNA + H2O = tetrahydrofolate + N-formylmethionyl-tRNA.


translation termination factor activity

Functions in the termination of translation.


mitochondrial inner boundary membrane

The portion of the mitochondrial inner membrane that is not invaginated to form cristae. The inner boundary membrane lies parallel to the outer membrane.


PELO_HUMAN Protein pelota homolog (sprot)

A protein pelota that is encoded in the genome of human.


SH3G2_HUMAN Endophilin-A1 (sprot)

An endophilin-A1 that is encoded in the genome of human.


TBC20_HUMAN TBC1 domain family member 20 (sprot)

A TBC1 domain family member 20 that is encoded in the genome of human.


RRFM_HUMAN Ribosome-recycling factor, mitochondrial (sprot)

A ribosome-recycling factor, mitochondrial that is encoded in the genome of human.


IF3M_HUMAN Translation initiation factor IF-3, mitochondrial (sprot)

A translation initiation factor IF-3, mitochondrial that is encoded in the genome of human.


IF2M_HUMAN Translation initiation factor IF-2, mitochondrial (sprot)

A translation initiation factor IF-2, mitochondrial that is encoded in the genome of human.


RASL2_HUMAN Ras GTPase-activating protein 4 (sprot)

A Ras GTPase-activating protein 4 that is encoded in the genome of human.


RASL1_HUMAN RasGAP-activating-like protein 1 (sprot)

A RasGAP-activating-like protein 1 that is encoded in the genome of human.


RASA3_HUMAN Ras GTPase-activating protein 3 (sprot)

A Ras GTPase-activating protein 3 that is encoded in the genome of human.


RASA2_HUMAN Ras GTPase-activating protein 2 (sprot)

A Ras GTPase-activating protein 2 that is encoded in the genome of human.


DAB2P_HUMAN Disabled homolog 2-interacting protein (sprot)

A disabled homolog 2-interacting protein that is encoded in the genome of human.


RASL3_HUMAN RAS protein activator like-3 (sprot)

A RAS protein activator like-3 that is encoded in the genome of human.


SYGP1_HUMAN Ras/Rap GTPase-activating protein SynGAP (sprot)

A Ras/Rap GTPase-activating protein SynGAP that is encoded in the genome of human.


NGAP_HUMAN Ras GTPase-activating protein nGAP (sprot)

A Ras GTPase-activating protein nGAP that is encoded in the genome of human.


ERF3A_HUMAN Eukaryotic peptide chain release factor GTP-binding subunit ERF3A (sprot)

A eukaryotic peptide chain release factor GTP-binding subunit ERF3A that is encoded in the genome of human.


HBS1L_HUMAN HBS1-like protein (sprot)

An HBS1-like protein that is encoded in the genome of human.


RRF2M_HUMAN Ribosome-releasing factor 2, mitochondrial (sprot)

An elongation factor G 2, mitochondrial that is encoded in the genome of human.


K1KB5_MOUSE Kallikrein 1-related peptidase b5 (sprot)

A kallikrein 1-related peptidase b5 that is encoded in the genome of mouse.


regulation of peptidase activity

Any process that modulates the frequency, rate or extent of peptidase activity, the hydrolysis of peptide bonds within proteins.


Q6DR99_MOUSE Pro-neuregulin-1, membrane-bound isoform (trembl)

A pro-neuregulin-1, membrane-bound isoform (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q6DR99.


SLIT2_HUMAN Slit homolog 2 protein (sprot)

A slit homolog 2 protein that is encoded in the genome of human.


DCD_HUMAN Dermcidin (sprot)

A dermcidin that is encoded in the genome of human.


gamma-secretase complex

A protein complex that has aspartic-type endopeptidase activity and contains a presenilin catalytic subunit (either PSEN1 or PSEN2), an APH1 subunit (multiple genes and splice variants exist), nicastrin (NCT), and presenilin enhancer (aka PEN-2 or Psenen), as the core complex. Variants of the complex with different subunit compositions differ in localization and specific substrates. Additionally, variants of the complex exist that contain a additional regulatory subunit as well as the four core subunits; known regulatory subunits include gamma-secretase-activating protein (aka gSAP), TMP1 (aka TMED10), and CD147 antigen (aka basigin). Gamma-secretase cleaves type I transmembrane protein substrates, including the cell surface receptor Notch and the amyloid-beta precursor protein.


protein unfolding

The process of assisting in the disassembly of non-covalent linkages in a protein or protein aggregate, often where the proteins are in a non-functional or denatured state.


mitochondrial genome maintenance

The maintenance of the structure and integrity of the mitochondrial genome; includes replication and segregation of the mitochondrial chromosome.


Catalysis of the reaction: UDP-galactose + N-acetylglucosamine = galactose-beta-1,3-N-acetylglucosamine + UDP.


galactosyltransferase activity

Catalysis of the transfer of a galactosyl group to an acceptor molecule, typically another carbohydrate or a lipid.


pseudohyphal growth

The process in which cells grow as a chain of physically attached, elongated cells in response to an environmental stimulus or stimuli.


invasive filamentous growth

The growth of colonies in filamentous chains of cells into a substrate.


CHM2A_HUMAN Charged multivesicular body protein 2a (sprot)

A charged multivesicular body protein 2a that is encoded in the genome of human.


GOSR1_HUMAN Golgi SNAP receptor complex member 1 (sprot)

A Golgi SNAP receptor complex member 1 that is encoded in the genome of human.


BET1L_HUMAN BET1-like protein (sprot)

A BET1-like protein that is encoded in the genome of human.


STX18_HUMAN Syntaxin-18 (sprot)

A syntaxin-18 that is encoded in the genome of human.


USE1_HUMAN Vesicle transport protein USE1 (sprot)

A vesicle transport protein USE1 that is encoded in the genome of human.


VAMP3_HUMAN Vesicle-associated membrane protein 3 (sprot)

A vesicle-associated membrane protein 3 that is encoded in the genome of human.


STX10_HUMAN Syntaxin-10 (sprot)

A syntaxin-10 that is encoded in the genome of human.


CHMP3_HUMAN Charged multivesicular body protein 3 (sprot)

A charged multivesicular body protein 3 that is encoded in the genome of human.


CHMP6_HUMAN Charged multivesicular body protein 6 (sprot)

A charged multivesicular body protein 6 that is encoded in the genome of human.


CHMP7_HUMAN Charged multivesicular body protein 7 (sprot)

A charged multivesicular body protein 7 that is encoded in the genome of human.


IST1_HUMAN IST1 homolog (sprot)

An IST1 homolog that is encoded in the genome of human.


VPS4A_HUMAN Vacuolar protein sorting-associated protein 4A (sprot)

A vacuolar protein sorting-associated protein 4A that is encoded in the genome of human.


CHM4B_HUMAN Charged multivesicular body protein 4b (sprot)

A charged multivesicular body protein 4b that is encoded in the genome of human.


C2D1B_HUMAN Coiled-coil and C2 domain-containing protein 1B (sprot)

A coiled-coil and C2 domain-containing protein 1B that is encoded in the genome of human.


CHM2B_HUMAN Charged multivesicular body protein 2b (sprot)

A charged multivesicular body protein 2b that is encoded in the genome of human.


CHM4C_HUMAN Charged multivesicular body protein 4c (sprot)

A charged multivesicular body protein 4c that is encoded in the genome of human.


CHM4A_HUMAN Charged multivesicular body protein 4a (sprot)

A charged multivesicular body protein 4a that is encoded in the genome of human.


ASCC2_HUMAN Activating signal cointegrator 1 complex subunit 2 (sprot)

An activating signal cointegrator 1 complex subunit 2 that is encoded in the genome of human.


octopamine receptor activity

Combining with the biogenic amine octopamine to initiate a change in cell activity. Octopamine is found in both vertebrates and invertebrates and can have properties both of a hormone and a neurotransmitter and acts as an adrenergic agonist.


ochratoxin A biosynthetic process

The chemical reactions and pathways resulting in the formation of ochratoxin A.


zearalenone biosynthetic process

The chemical reactions and pathways resulting in the formation of zearalenone, a mycotoxin produced by several Fusarium species, is most commonly found as a contaminant in stored grain and has chronic estrogenic effects on mammals.


terrequinone A biosynthetic process

The chemical reactions and pathways resulting in the formation of terrequinone A.


regulation of catalytic activity

Any process that modulates the activity of an enzyme.


non-ribosomal peptide synthetase activity

Catalysis of a multistep reaction that produce non-ribosomal peptides. The key chain-building reaction, a C-N bond-forming reaction, involves the generation of the characteristic peptide bond by nucleophilic attack of the amino group of an amino-acyl donor unit covalently bound to a downstream peptidyl carrier protein module (amino acyl-S-PCP) on the acyl group of an upstream electrophilic acyl- or peptidyl acyl-S-PCP chain, catalyzed by a condensation (C) domain. Supplementing these core chain-elongation domains are variable numbers of auxiliary domains that are responsible for modification of the growing polypeptide chain by a small set of iterated reactions including epimerization, N-methylation, and heterocyclization.


transcription regulator activator activity

A molecular function regulator that increases the activity of a transcription regulator via direct binding and/or post-translational modification.


positive regulation of catalytic activity

Any process that activates or increases the activity of an enzyme.


malonyl-CoA

The S-malonyl derivative of coenzyme A.


Acetyl coenzyme A

An acyl-CoA having acetyl as its S-acetyl component.


Ochratoxin A

A phenylalanine derivative resulting from the formal condensation of the amino group of L-phenylalanine with the carboxy group of (3R)-5-chloro-8-hydroxy-3-methyl-1-oxo-3,4-dihydro-1H-2-benzopyran-7-carboxylic acid (ochratoxin alpha). It is among the most widely occurring food-contaminating mycotoxins, produced by Aspergillus ochraceus, Aspergillus carbonarius and Penicillium verrucosum.


TERREQUINONE A

A bisindole alkaloid that is quinone bearing a hydroxy substituent at position 2, a 3,3-dimethylallyl group at position 5 and two indol-3-yl groups at positions 3 and 6, one of which is carrying a 1,1-dimethylallyl group at position 2.


OTAD_ASPC5 Flavin-dependent halogenase otaD (sprot)


OTAD_ASPNC Flavin-dependent halogenase otaD (sprot)


OTAA_ASPNC Highly reducing polyketide synthase otaA (sprot)


ZEA1_GIBZE Non-reducing polyketide synthase ZEA1 (sprot)


TDIE_EMENI Probable methyltransferase tdiE (sprot)


uroporphyrinogen decarboxylase

A protein that is a translation product of the human UROD gene or a 1:1 ortholog thereof.


type II iodothyronine deiodinase

A protein that is a translation product of the human DIO2 gene or a 1:1 ortholog thereof.


type I iodothyronine deiodinase

A protein that is a translation product of the human DIO1 gene or a 1:1 ortholog thereof.


OTAB_ASPC5 Nonribosomal peptide synthetase otaB (sprot)


OTAC_ASPC5 Cytochrome P450 monooxygenase otaC (sprot)


OTAA_ASPC5 Highly reducing polyketide synthase otaA (sprot)


OTAB_ASPNC Nonribosomal peptide synthetase otaB (sprot)


OTAC_ASPNC Cytochrome P450 monooxygenase otaC (sprot)


ZEB2_GIBZE Transcription factor ZEB2 (sprot)


ZEA2_GIBZE Highly reducing polyketide synthase ZEA2 (sprot)


TDIB_EMENI Indole prenyltransferase tdiB (sprot)


TDIA_EMENI Didemethylasterriquinone D synthetase tdiA (sprot)


TDIC_EMENI Probable NADPH-dependent quinone reductase tdiC (sprot)


GDP-mannose biosynthetic process

The chemical reactions and pathways resulting in the formation of GDP-mannose, a substance composed of mannose in glycosidic linkage with guanosine diphosphate.


alpha-D-mannose 1-phosphate

A D-mannose 1-phosphate with an alpha-configuration at the anomeric position.


Hydrochloric Acid

A mononuclear parent hydride consisting of covalently bonded hydrogen and chlorine atoms.


antigen processing and presentation of endogenous peptide antigen via MHC class I

The process in which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC class I protein complex. The peptide antigen is typically, but not always, processed from a whole protein. Class I here refers to classical class I molecules.


positive regulation of protein-pyridoxal-5-phosphate linkage

Any process that activates or increases the frequency, rate or extent of protein-pyridoxal-5-phosphate linkage.


US06_HCMVA Unique short US6 glycoprotein (sprot)


Golgi apparatus mannose trimming

Any protein alpha-1,2-demannosylation that takes place in the Golgi apparatus.


Catalysis of the reaction: 3-(alpha-D-mannosyl)-beta-D-mannosyl-R + UDP-N-acetyl-alpha-D-glucosamine = 3-(2-[N-acetyl-beta-D-glucosaminyl]-alpha-D-mannosyl)-beta-D-mannosyl-R + H+ + UDP.


endoplasmic reticulum quality control compartment

A subcompartment of the endoplasmic reticulum in which proteins with improper or incorrect folding accumulate. Enzymes in this compartment direct proteins with major folding problems to translocation to the cytosol and degradation, and proteins with minor folding problems to the ER, to interact with chaperon proteins.


An N(4)-glycosylated asparagine residue in which the glycan moiety is a branched nonasaccharide consisting of seven D-mannosyl residues and two N-acetylglucosamine residues, one of which at the reducing end is bonded to the asparagine N(4) atom.


An N-glycan residue involved in post-translational modification of proteins.


An N(4)-glycosylated asparagine residue in which the glycan moiety is a branched decasaccharide consisting of eight D-mannosyl residues and two N-acetylglucosamine residues, one of which at the reducing end is bonded to the asparagine N(4) atom.


MA1A2_HUMAN Mannosyl-oligosaccharide 1,2-alpha-mannosidase IB (sprot)

A mannosyl-oligosaccharide 1,2-alpha-mannosidase IB that is encoded in the genome of human.


MA1A1_HUMAN Mannosyl-oligosaccharide 1,2-alpha-mannosidase IA (sprot)

A mannosyl-oligosaccharide 1,2-alpha-mannosidase IA that is encoded in the genome of human.


MA1C1_HUMAN Mannosyl-oligosaccharide 1,2-alpha-mannosidase IC (sprot)

A mannosyl-oligosaccharide 1,2-alpha-mannosidase IC that is encoded in the genome of human.


dGMP catabolic process

The chemical reactions and pathways resulting in the breakdown of dGMP, deoxyguanosine monophosphate (2'-deoxyguanosine 5'-phosphate).


xanthine catabolic process

The chemical reactions and pathways resulting in the breakdown of xanthine, 2,6-dihydroxypurine, a purine formed in the metabolic breakdown of guanine but not present in nucleic acids.


inosine catabolic process

The chemical reactions and pathways resulting in the breakdown of inosine, hypoxanthine riboside, a nucleoside found free but not in combination in nucleic acids except in the anticodons of some tRNAs.


AMP catabolic process

The chemical reactions and pathways resulting in the breakdown of AMP, adenosine monophosphate.


GMP catabolic process

The chemical reactions and pathways resulting in the breakdown of GMP, guanosine monophosphate.


dAMP catabolic process

The chemical reactions and pathways resulting in the breakdown of dAMP, deoxyadenosine monophosphate (2'-deoxyadenosine 5'-phosphate).


IMP catabolic process

The chemical reactions and pathways resulting in the breakdown of IMP, inosine monophosphate.


hypoxanthine catabolic process

The chemical reactions and pathways resulting in the breakdown of hypoxanthine, 6-hydroxy purine, an intermediate in the degradation of adenylate. Its ribonucleoside is known as inosine and its ribonucleotide as inosinate.


guanine catabolic process

The chemical reactions and pathways resulting in the breakdown of guanine, 2-amino-6-hydroxypurine, a purine that is one of the five main bases found in nucleic acids and a component of a number of phosphorylated guanosine derivatives whose metabolic or regulatory functions are important.


deoxyguanosine catabolic process

The chemical reactions and pathways resulting in the breakdown of deoxyguanosine, a nucleoside consisting of the base guanine and the sugar deoxyribose.


deoxyinosine catabolic process

The chemical reactions and pathways resulting in the breakdown of deoxyinosine, hypoxanthine deoxyriboside.


RL4_MOUSE Large ribosomal subunit protein uL4 (sprot)

A 60S ribosomal protein L4 that is encoded in the genome of mouse.


HMGB2_MOUSE High mobility group protein B2 (sprot)

A high mobility group protein B2 that is encoded in the genome of mouse.


3BP2_MOUSE SH3 domain-binding protein 2 (sprot)

An SH3 domain-binding protein 2 that is encoded in the genome of mouse.


KNDC1_MOUSE Kinase non-catalytic C-lobe domain-containing protein 1 (sprot)

A kinase non-catalytic C-lobe domain-containing protein 1 that is encoded in the genome of mouse.


PTPRO_MOUSE Receptor-type tyrosine-protein phosphatase O (sprot)

A receptor-type tyrosine-protein phosphatase O that is encoded in the genome of mouse.


3BP1_MOUSE SH3 domain-binding protein 1 (sprot)

A protein that is a translation product of the Sh3bp1 gene in mouse.


PO2F2_MOUSE POU domain, class 2, transcription factor 2 (sprot)

A POU domain, class 2, transcription factor 2 that is encoded in the genome of mouse.


ERMES complex

A protein complex that links the endoplasmic reticulum with mitochondria and may have a role in promoting exchange of calcium and phospholipids between the two organelles.


apoptotic process in response to mitochondrial fragmentation

Any apoptotic process that occurs as a result of mitochondrial fragmentation.


mannose metabolic process

The chemical reactions and pathways involving mannose, the aldohexose manno-hexose, the C-2 epimer of glucose. The D-(+)-form is widely distributed in mannans and hemicelluloses and is of major importance in the core oligosaccharide of N-linked oligosaccharides of glycoproteins.


D-mannose 6-phosphate

A mannose phosphate in which the phosphate group is attached to position 6.


The pyranose form of D-mannose 6-phosphate.


alpha-D-mannose 1-phosphate(2-)

An organophosphate oxoanion that is the dianion of alpha-D-mannose 1-phosphate.


Golgi medial cisterna

The middle Golgi cisterna (or cisternae).


positive regulation by host of viral process

A process in which a host organism activates or increases the frequency, rate or extent of the release of a process being mediated by a virus with which it is infected.


peptidyl-L-cysteine S-palmitoylation

The covalent attachment of a palmitoyl group to a sulfur (S) atom within a cysteine residue to form peptidyl-S-palmitoyl-L-cysteine.


protein localization to membrane raft

A process in which a protein is transported to, or maintained in, a location within a membrane raft.


structural constituent of virion

The action of a molecule that contributes to the structural integrity of a virion.


estrogen receptor isoform h3 (human)

An estrogen receptor (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P03372-3.


ESR2_HUMAN Estrogen receptor beta (sprot)

An estrogen receptor beta that is encoded in the genome of human.


ZDH20_HUMAN Palmitoyltransferase ZDHHC20 (sprot)

A palmitoyltransferase ZDHHC20 that is encoded in the genome of human.


HMOX1_HUMAN Heme oxygenase 1 (sprot)

A heme oxygenase 1 that is encoded in the genome of human.


HM13_HUMAN Minor histocompatibility antigen H13 (sprot)

A minor histocompatibility antigen H13 that is encoded in the genome of human.


calcium ion import into sarcoplasmic reticulum

The directed movement of calcium ions into a sarcoplasmic reticulum.


cuticle development involved in collagen and cuticulin-based cuticle molting cycle

Synthesis and deposition of a collagen and cuticulin-based noncellular, hardened, or membranous secretion from an epithelial sheet, occurring as part of the molting cycle. An example of this process is found in Caenorhabditis elegans.


positive regulation of protein processing

Any process that increases the rate, frequency or extent of protein maturation by peptide bond cleavage.


phagolysosome

A membrane-bounded intracellular vesicle formed by maturation of an early phagosome following the ingestion of particulate material by phagocytosis; during maturation, phagosomes acquire markers of late endosomes and lysosomes.


4-Nitrophenyl butyrate

A butyrate ester resulting from the formal condensation of the hydroxy group of 4-nitrophenol with the carboxy group of butyric acid.


Presqualene monophosphate

A triterpenyl phosphate that is presqualene in which the hydroxy hydrogen has been replaced by a monophosphate group.


diketone

A compound that contains two ketone functionalities.


Pseudouridine

A C-glycosyl pyrimidine that consists of uracil having a beta-D-ribofuranosyl residue attached at position 5. The C-glycosyl isomer of the nucleoside uridine.


NLRP3 inflammasome complex

An inflammasome complex that consists of three components, NLRP3 (NALP3), PYCARD and caspase-1. It is activated upon exposure to whole pathogens, as well as a number of structurally diverse pathogen- and danger-associated molecular patterns (PAMPs and DAMPs) and environmental irritants. Whole pathogens demonstrated to activate the NLRP3 inflammasome complex include the fungi Candida albicans and Saccharomyces cerevisiae, bacteria that produce pore-forming toxins, including Listeria monocytogenes and Staphylococcus aureus, and viruses such as Sendai virus, adenovirus, and influenza virus.


nasal mucus

Mucus produced in the nasal cavity, by the respiratory segment of the nasal mucosa.


outer dynein arm assembly

The aggregation, arrangement and bonding together of a set of components to form an axonemal dynein outer arm, an outer arm structure present on the outer doublet microtubules of ciliary and flagellar axonemes.


ecto-epithelial cell of viscerocranial mucosa

biolink:Cell biolink:AnatomicalEntity biolink:OrganismalEntity biolink:BiologicalEntity biolink:NamedThing biolink:PhysicalEssence biolink:SubjectOfInvestigation biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

An epithelial cell of the mucosa associated with facial skeleton.


respiratory ciliated cell

A ciliated cell of the respiratory system. Ciliated cells are present in airway epithelium.


apical cytoplasm

The region of the cytoplasm located at the apical side of the cell. Used in reference to animal polarized epithelial cells.


subapical part of cell

The region of a polarized cell that is just below the apical region. For example, in a polarized epithelial cell, the apical region has an exposed surface and lies opposite to the basal lamina that separates the epithelium from other tissue so the subapical region is further from the exposed surface and closer to the basal lamina.


ciliary transition fiber

A nine-bladed, propeller-like protein complex that links the distal end of the basal body and the cilium to the plasma membrane. Functions in protein sorting and gating (i.e. active and passive transport of proteins in and out of the cilium).


multi-ciliated epithelial cell differentiation

The process in which a relatively unspecialized cell acquires the specialized features of a multi-ciliated epithelial cell.


zonula adherens assembly

Assembly of the zonula adherens, a cell-cell adherens junction which forms a continuous belt near the apex of epithelial cells.


maintenance of ciliary planar beating movement pattern

Any process involved in maintaining the planar beating pattern of ciliary movement pattern. Connection between the outer doublets and the central pair via the radial spokes constrains ciliary movement to the planar beating pattern. Cilia that lack this connection, such as those in the embryonic node or Kupfer's vesicle, display radial movement.


positive regulation of motile cilium assembly

Any process that activates or increases the frequency, rate or extent of motile cilium assembly.


dynein heavy chain binding

Binding to a heavy chain of the dynein complex.


DYHC1_MOUSE Cytoplasmic dynein 1 heavy chain 1 (sprot)

A cytoplasmic dynein 1 heavy chain 1 that is encoded in the genome of mouse.


cyclic nucleotide-gated monoatomic ion channel activity

Enables the transmembrane transfer of an ion by a channel that opens when a cyclic nucleotide has been bound by the channel complex or one of its constituent parts.


voltage-gated monoatomic ion channel activity

Enables the transmembrane transfer of an ion by a voltage-gated channel. An ion is an atom or group of atoms carrying an electric charge by virtue of having gained or lost one or more electrons. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded.


detection of cAMP

The series of events in which a cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate) stimulus is received by a cell and converted into a molecular signal; cAMP is the nucleotide cyclic AMP.


otolith development

The process whose specific outcome is the progression of the otolith over time, from its formation to the mature structure.


neuromast hair cell development

The process whose specific outcome is the progression of a neuromast hair cell over time, from its formation to the mature structure. A neuromast hair cell is a hair cell that acts as a sensory receptor of the neuromast; it is morphologically polarized as a result of the relative position of the single kinocilium and the clusters of stereocilia on its apical surface. Cell development does not include the steps involved in committing a cell to a specific fate.


meiotic cell cycle process involved in oocyte maturation

Any meiotic cell cycle process that is involved in oocyte maturation.


regulation of MAPK cascade

Any process that modulates the frequency, rate or extent of signal transduction mediated by the MAP kinase (MAPK) cascade.


fibroblast growth factor receptor binding

Binding to a fibroblast growth factor receptor (FGFR).


neutrophil migration

The movement of a neutrophil within or between different tissues and organs of the body.


positive regulation of circadian rhythm

Any process that activates or increases the frequency, rate or extent of a circadian rhythm behavior.


positive regulation of hemopoiesis

Any process that activates or increases the frequency, rate or extent of hemopoiesis.


synaptic receptor adaptor activity

The binding activity of a molecule that provides a physical support bridging a synaptic signaling receptor and a downstream signaling molecule.


regulation of neutrophil chemotaxis

Any process that modulates the frequency, rate, or extent of neutrophil chemotaxis. Neutrophil chemotaxis is the directed movement of a neutrophil cell, the most numerous polymorphonuclear leukocyte found in the blood, in response to an external stimulus, usually an infection or wounding.


regulation of sarcomere organization

Any process that modulates the rate, frequency or extent of myofibril assembly by organization of muscle actomyosin into sarcomeres. The sarcomere is the repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs.


regulation of mitochondrion organization

Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a mitochondrion.


neuromast regeneration

The regrowth of a neuromast following its loss or destruction.


undifferentiated genital tubercle

The embryonic anlage of the external genitalia, which emerges as paired swellings ventral to the cloacal membrane, is proposed to be derived from all three germ layers, and gives rise to the penis, clitoris, scrotum, labia, and foreskin.


partitioning defective 3 homolog isoform 3 (mouse)

A partitioning defective 3 homolog (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q99NH2-3.


oocyte animal/vegetal axis specification

The establishment, maintenance and elaboration of the animal/vegetal axis in the oocyte. The animal/vegetal axis of an oocyte is defined by the placement of the nucleus in the oocyte and can sometimes be identified by the asymmetric placement of other substances such as yolk in the oocyte. The pole of the egg that is closest to the nucleus defines the animal end, with the axis passing through the nucleus.


ganglion of central nervous system

A ganglion that is part of a central nervous system [Automatically generated definition].


optic chiasma

A decussation of the diencephalon where the fibers of the optic nerve cross.


spinal accessory motor neuron

A motor neuron that is located in the cervical region of the spinal cord and selectively innervates the sternocleidmastoid or trapezius muscle. Unlike other motor neurons, they extend axons dorsally along lateral margins of the spinal cord.


IAPP_MOUSE Islet amyloid polypeptide (sprot)

An islet amyloid polypeptide that is encoded in the genome of mouse.


mammary gland development

The process whose specific outcome is the progression of the mammary gland over time, from its formation to the mature structure. The mammary gland is a large compound sebaceous gland that in female mammals is modified to secrete milk. Its development starts with the formation of the mammary line and ends as the mature gland cycles between nursing and weaning stages.


clathrin adaptor complex

A membrane coat adaptor complex that links clathrin to a membrane.


palmitoleoyltransferase activity

Catalysis of the transfer of a palmitoleyl group, a 16-carbon monounsaturated fatty acid (C16:1), to an acceptor molecule.


calyx of Held

The terminal specialization of a calyciferous axon which forms large synapses in the mammalian auditory central nervous system.


negative regulation of synaptic vesicle exocytosis

Any process that stops, prevents or reduces the frequency, rate or extent of synaptic vesicle exocytosis.


D7PBZ9_CARAU Syntaxin 3B (Fragment) (trembl)


regulation of glial cell differentiation

Any process that modulates the frequency, rate or extent of glia cell differentiation.


embryonic camera-type eye development

The process occurring during the embryonic phase whose specific outcome is the progression of the eye over time, from its formation to the mature structure.


optic cup formation involved in camera-type eye development

The developmental process pertaining to the initial formation of the optic cup, a two-walled vesicle formed from the optic vesicle.


regulation of receptor internalization

Any process that modulates the frequency, rate or extent of receptor internalization.


notochord cell development

The process whose specific outcome is the progression of a notochord cell over time, from its formation to its mature structure. Cell development does not include the steps involved in committing a cell to a specific fate.


rhombomere development

The process whose specific outcome is the progression of the rhombomere over time, from its formation to the mature structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates.


anterior lateral line development

The process whose specific outcome is the progression of the anterior lateral line over time, from its formation to the mature structure. The anterior lateral line consists of small sensory patches (neuromasts) located superficially on the skin or just under the skin in fluid-filled canals on the head of all fishes and most amphibians. The anterior lateral line develops from cranial ectodermal placodes situated between the eye and ear.


pigment cell differentiation

The process in which a relatively unspecialized cell acquires the specialized features of a pigmented cell, such as a melanocyte.


pronephric duct development

The process whose specific outcome is the progression of the pronephric duct over time, from its formation to the mature structure. The pronephric duct collects the filtrate from the pronephric tubules and opens to the exterior of the pronephric kidney.


trigeminal ganglion development

The process whose specific outcome is the progression of a trigeminal ganglion over time, from its formation to the mature structure.


taste bud formation

The developmental process pertaining to the initial formation of the taste bud from unspecified parts. The taste bud is a specialized area of the tongue that contains taste receptors.


lateral line nerve development

The process whose specific outcome is the progression of the lateral line nerve over time, form its formation to the mature structure. Lateral line nerves project primarily to an octavolateralis column in the hindbrain that consists of the medial octavolateralis nucleus (MON), the caudal octavolateralis nucleus, and the magnocellular nucleus.


lipid droplet formation

A process that results in the assembly, arrangement of constituent parts of a lipid droplet.


cytosolic lipolysis

The chemical reactions and pathways resulting in the breakdown of lipid droplets and hydrolysis of stored triglycerides occurring through the orchestrated activation of cytosolic lipases.


diacylglycerol metabolic process

The chemical reactions and pathways involving diacylglycerol, a glyceride in which any two of the R groups (positions not specified) are acyl groups while the remaining R group can be either H or an alkyl group.


regulation of multicellular organism growth

Any process that modulates the frequency, rate or extent of growth of the body of an organism so that it reaches its usual body size.


glandular epithelial cell maturation

The developmental process, independent of morphogenetic (shape) change, that is required for a glandular epithelial cell to attain its fully functional state. A glandular epithelial cell is a columnar/cuboidal epithelial cell is a cell found in a two dimensional sheet with a free surface exposed to the lumen of a gland.


cellular response to dithiothreitol

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a dithiothreitol stimulus.


oxoglutarate dehydrogenase (succinyl-transferring) activity

Catalysis of the reaction: 2-oxoglutarate + lipoamide + H+ = S-succinyldihydrolipoamide + CO2.


A nine-membered branched glucosamine oligosaccharide consisting of eight D-mannosyl residues and one N-acetylglucosamine residue (the latter being located at the reducing end). An intermediate glycan structure of glycosylated proteins.


mitochondrial isocitrate dehydrogenase complex (NAD+)

Mitochondrial complex that possesses isocitrate dehydrogenase (NAD+) activity.


oxoglutarate dehydrogenase complex

A complex of multiple copies of three enzymatic components: oxoglutarate dehydrogenase (lipoamide) (E1), dihydrolipoamide S-succinyltransferase (E2) and dihydrolipoamide dehydrogenase (E3); catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and carbon dioxide (CO2).


succinate-CoA ligase complex (ADP-forming)

A heterodimeric enzyme complex, composed of an alpha and beta chain, most usually found in (but not limited to) bacteria. Functions in the TCA cycle, hydrolyzing succinyl-CoA into succinate and CoA, thereby forming ATP.


succinate-CoA ligase complex (GDP-forming)

A heterodimeric enzyme complex, usually composed of an alpha and beta chain. Functions in the TCA cycle, hydrolyzing succinyl-CoA into succinate and CoA, thereby forming GTP.


gamma-aminobutyric acid:proton symporter activity

Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: gamma-aminobutyric acid(out) + H+(out) = gamma-aminobutyric acid(in) + H+(in).


positive regulation of monoatomic ion transport

Any process that activates or increases the frequency, rate or extent of the directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


CTNS_HUMAN Cystinosin (sprot)

A cystinosin that is encoded in the genome of human.


small conductance calcium-activated potassium channel protein 2 isoform 1 (mouse)

A small conductance calcium-activated potassium channel protein 2 isoform 1 that is encoded in the genome of mouse.


negative regulation of ceramide biosynthetic process

Any process that stops, prevents or reduces the frequency, rate or extent of a ceramide biosynthetic process.


negative regulation of phosphatidylcholine biosynthetic process

Any process that stops, prevents or reduces the frequency, rate or extent of phosphatidylcholine biosynthetic process.


negative regulation of inositol biosynthetic process

Any process that stops, prevents or reduces the frequency, rate or extent of inositol biosynthetic process.


negative regulation of phosphatidylserine biosynthetic process

Any process that stops, prevents or reduces the frequency, rate or extent of phosphatidylserine biosynthetic process.


negative regulation of pseudohyphal growth

Any process that stops, prevents, or reduces the frequency, rate or extent of pseudohyphal growth.


negative regulation of invasive growth in response to glucose limitation

Any process that stops, prevents, or reduces the frequency, rate or extent of invasive growth in response to glucose limitation.


negative regulation of dipeptide transport

Any process that stops, prevents or reduces the frequency, rate or extent of dipeptide transport.


mating type determination

Any process that establishes and transmits the specification of mating type upon an individual. Mating types are the equivalent in microorganisms of the sexes in higher organisms.


negative regulation of sterol import

Any process that stops, prevents or reduces the frequency, rate or extent of sterol import.


negative regulation of mating type switching

Any process that stops, prevents, or reduces the frequency, rate or extent of mating type switching.


positive regulation of induction of conjugation with cellular fusion

Any process that activates or increases the frequency, rate or extent of induction of conjugation with cellular fusion.


negative regulation of filamentous growth of a population of unicellular organisms

Any process that stops, prevents or reduces the frequency, rate or extent of filamentous growth of a population of unicellular organisms.


negative regulation of arginine catabolic process

Any process that stops, prevents or reduces the frequency, rate or extent of arginine catabolic process.


negative regulation of oligopeptide transport

Any process that stops, prevents or reduces the frequency, rate or extent of oligopeptide transport.


protein poly-ADP-ribosylation

The transfer of multiple ADP-ribose residues from NAD to a protein amino acid, forming a poly(ADP-ribose) chain.


histone H3K deacetylase activity

Catalysis of the reaction: histone H3 N6-acetyl-L-lysine + H2O = histone H3 L-lysine + acetate. This reaction represents the removal of an acetyl group from a histone H3.


SKI_HUMAN Ski oncogene (sprot)

A ski oncogene that is encoded in the genome of human.


SNW1_HUMAN SNW domain-containing protein 1 (sprot)

A SNW domain-containing protein 1 that is encoded in the genome of human.


AT1B4_HUMAN Protein ATP1B4 (sprot)

A protein ATP1B4 that is encoded in the genome of human.


KCTD1_HUMAN BTB/POZ domain-containing protein KCTD1 (sprot)

A BTB/POZ domain-containing protein KCTD1 that is encoded in the genome of human.


KCD15_HUMAN BTB/POZ domain-containing protein KCTD15 (sprot)

A BTB/POZ domain-containing protein KCTD15 that is encoded in the genome of human.


SKIL_HUMAN Ski-like protein (sprot)

A ski-like protein that is encoded in the genome of human.


TGIF1_HUMAN Homeobox protein TGIF1 (sprot)

A homeobox protein TGIF1 that is encoded in the genome of human.


TGIF2_HUMAN Homeobox protein TGIF2 (sprot)

A homeobox protein TGIF2 that is encoded in the genome of human.


cellular response to increased oxygen levels

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting an increase in the level of oxygen.


tumor protein 63 isoform 6 (mouse)

A tumor protein 63 isoform 6 that is encoded in the genome of mouse.


FOG2_MOUSE Zinc finger protein ZFPM2 (sprot)

A zinc finger protein ZFPM2 that is encoded in the genome of mouse.


positive regulation of glial cell differentiation

Any process that activates or increases the frequency, rate or extent of glia cell differentiation.


negative regulation of glial cell differentiation

Any process that stops, prevents, or reduces the frequency, rate or extent of glia cell differentiation.


gliogenesis

The process that results in the generation of glial cells. This includes the production of glial progenitors and their differentiation into mature glia.


cardiac jelly development

The process whose specific outcome is the progression of cardiac jelly over time, from its formation to the mature structure. The cardiac jelly is an acellular gelatinous matrix secreted by the myocardium and plays a central role in the septation of the heart.


endothelial to hematopoietic transition

The generation of hematopoietic stem cells from hemogenic endothelial cells by a process that includes tight-junction dissolution and loss of cell polarity followed by delamination from the endothelium.


regulation of interleukin-13 production

Any process that modulates the frequency, rate, or extent of interleukin-13 production.


primitive erythrocyte differentiation

Erythrocyte differentiation which occurs as part of the process of primitive hemopoiesis.


forebrain neuroblast division

The division of a neuroblast located in the forebrain. Neuroblast division gives rise to at least another neuroblast.


elicited macrophage

A macrophage which develops from an inflammatory monocyte and is recruited into the tissues in response to injury and infection as part of an inflammatory response. Markers include CD11b-positive, CD68-positive, and F4/80-positive.


neural rod formation

The formation of a solid rod of neurectoderm derived from the neural keel. The neural rod is roughly circular in cross section. Neural rod formation occurs during primary neurulation in teleosts.


Axin-1 isoform 1 (mouse)

An Axin-1 isoform 1 that is encoded in the genome of mouse.


phosphoamidase activity

Catalysis of the reaction: N-phosphocreatine + H2O = creatine + phosphate.


heme B transmembrane transporter activity

Enables the transfer of heme B from one side of a membrane to the other.


BH3-interacting domain death agonist isoform 1 cleaved 1 (mouse)

A BH3-interacting domain death agonist isoform 1 cleaved 1 in mouse. UniProtKB:P70444-1, 61-195.


feline leukemia virus subgroup C receptor-related protein 1 isoform m2 (mouse)

A feline leukemia virus subgroup C receptor-related protein 1 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:B2RXV4-2.


retrograde transport, endosome to Golgi

The directed movement of membrane-bounded vesicles from endosomes back to the trans-Golgi network where they are recycled for further rounds of transport.


negative regulation of receptor-mediated endocytosis

Any process that stops, prevents, or reduces the frequency, rate or extent of receptor mediated endocytosis, the uptake of external materials by cells, utilizing receptors to ensure specificity of transport.


Inosinic Acid

A purine ribonucleoside 5'-monophosphate having hypoxanthine as the nucleobase.


A purine ribonucleoside 5'-monophosphate having guanine as the nucleobase.


lipoteichoic acid

A teichoic acid which is covalently bound to a lipid.


A beta-D-glucan in which the glucose units are connected by (1->3) linkages.


oxidised phospholipid

The oxidised form of phospholipids, and a possible biomarker of atherogenesis.


L-Fucose

The pyranose form of L-fucose.


dextran sulfate

A polymer composed of repeating (1->6)-alpha-linked anhydroglucose sulfate units.


CID 71597331

A family of sulfated polysaccharides extracted from red seaweeds. The name is derived from a common name of red algae Chondrus crispus, "carrageen moss" (Irish moss).


SRCRL_HUMAN Soluble scavenger receptor cysteine-rich domain-containing protein SSC5D (sprot)

A soluble scavenger receptor cysteine-rich domain-containing protein SSC5D that is encoded in the genome of human.


scavenger receptor class B member 1 isoform 1 (human)

A scavenger receptor class B member 1 isoform 2 that is encoded in the genome of human.


SREC_HUMAN Scavenger receptor class F member 1 (sprot)

A scavenger receptor class F member 1 that is encoded in the genome of human.


STAB1_HUMAN Stabilin-1 (sprot)

A stabilin-1 that is encoded in the genome of human.


STAB2_HUMAN Stabilin-2 (sprot)

A stabilin-2 that is encoded in the genome of human.


HYOU1_HUMAN Hypoxia up-regulated protein 1 (sprot)

A hypoxia up-regulated protein 1 that is encoded in the genome of human.


OMPB1_NEIGO Major outer membrane protein P.IB (sprot)


SG3A2_HUMAN Secretoglobin family 3A member 2 (sprot)

A secretoglobin family 3A member 2 that is encoded in the genome of human.


hematite nanoparticle

An iron oxide nanoparticle composed of hematite (Fe2O3).


silicon dioxide nanoparticle

A nanoparticle consisting of silicon dioxide.


titanium dioxide nanoparticle

A nanoparticle consisting of titanium dioxide.


SUH_HUMAN Recombining binding protein suppressor of hairless (sprot)

A recombining binding protein suppressor of hairless that is encoded in the genome of human.


MAMD1_HUMAN Mastermind-like domain-containing protein 1 (sprot)

A mastermind-like domain-containing protein 1 that is encoded in the genome of human.


MAML2_HUMAN Mastermind-like protein 2 (sprot)

A mastermind-like protein 2 that is encoded in the genome of human.


MAML1_HUMAN Mastermind-like protein 1 (sprot)

A mastermind-like protein 1 that is encoded in the genome of human.


MAML3_HUMAN Mastermind-like protein 3 (sprot)

A mastermind-like protein 3 that is encoded in the genome of human.


protein PML isoform m1 (mouse)

A protein PML (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q60953-1.


histone H3-K27 demethylation

The modification of histone H3 by the removal of a methyl group from lysine at position 27 of the histone.


WNT11_MOUSE Protein Wnt-11 (sprot)

A protein Wnt-11 that is encoded in the genome of mouse.


sentrin-specific protease 2 isoform 2 (mouse)

A sentrin-specific protease 2 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q91ZX6-2.


VDTA1_BYSSP Non-reducing polyketide synthase VdtA (sprot)


DNA translocase activity

Generation of movement along a single- or double-stranded DNA molecule, driven by ATP hydrolysis.


RSC-type complex

A SWI/SNF-type complex that contains a bromodomain containing-protein, such as yeast Rsc1 or Rsc4 or mammalian PB1/BAF180. The RSC complex is generally recruited to RNA polymerase III promoters and is specifically recruited to RNA polymerase II promoters by transcriptional activators and repressors; it is also involved in non-homologous end joining.


SWI/SNF complex

A SWI/SNF-type complex that contains 8 to 14 proteins, including both conserved (core) and nonconserved components; contains the ATPase product of the yeast SNF2 or mammalian SMARCA4/BAF190A/BRG1 gene, or an ortholog thereof.


Ino80 complex

A multisubunit protein complex that contains the Ino80p ATPase; exhibits chromatin remodeling activity.


H33_HUMAN Histone H3.3 (sprot)

A histone H3.3 that is encoded in the genome of human.


H31T_HUMAN Histone H3.1t (sprot)

A histone H3.1t that is encoded in the genome of human.


negative regulation of adipose tissue development

Any process that stops, prevents or reduces the frequency, rate or extent of adipose tissue development.


NMNA1_HUMAN Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1 (sprot)

A nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1 that is encoded in the genome of human.


transcription factor Ovo-like 2 isoform 1 (mouse)

A transcription factor Ovo-like 2 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q8CIV7-1.


SC61B_HUMAN Protein transport protein Sec61 subunit beta (sprot)

A protein transport protein Sec61 subunit beta that is encoded in the genome of human.


C-8 sterol isomerase activity

Catalysis of the reaction which results in unsaturation at C-7 in the B ring of sterols.


squalene synthase activity

Catalysis of the reaction: presqualene diphosphate + NADPH = squalene + NADP+ + diphosphate.


C-22 sterol desaturase activity

Catalysis of the formation of the C-22(23) double bond in the sterol side chain. An example reaction: 5,7,24(28)-ergostatrienol + O2 + NADPH = 5,7,22,24(28)-ergostatetraenol + 2 H2O + NADP+.


peptide transmembrane transporter activity

Enables the transfer of a peptide from one side of a membrane to the other.


3-Hydroxybenzyl alcohol

A hydroxybenzyl alcohol that is phenol substituted at position C-3 by a hydroxymethyl group.


regulated endocrine-specific protein 18 isoform 1 (mouse)

A regulated endocrine-specific protein 18 isoform 1 that is encoded in the genome of mouse.


serine/threonine-protein kinase LMTK1 isoform 3 (mouse)

A serine/threonine-protein kinase LMTK1 isoform 3 that is encoded in the genome of mouse.


ATP-dependent (S)-NAD(P)H-hydrate dehydratase isoform m3 (mouse)

An ATP-dependent (S)-NAD(P)H-hydrate dehydratase (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9CZ42-3.


ceramide synthase isoform 3 (mouse)

A ceramide synthase (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q7TNV1-3.


ceramide synthase isoform 2 (mouse)

A ceramide synthase isoform 2 that is encoded in the genome of mouse.


CR3L4_MOUSE Cyclic AMP-responsive element-binding protein 3-like protein 4 (sprot)

A cyclic AMP-responsive element-binding protein 3-like protein 4 that is encoded in the genome of mouse.


patatin-like phospholipase domain-containing protein 7 isoform 1 (mouse)

A patatin-like phospholipase domain-containing protein 7 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:A2AJ88-1.


patatin-like phospholipase domain-containing protein 7 isoform 2 (mouse)

A patatin-like phospholipase domain-containing protein 7 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:A2AJ88-2.


patatin-like phospholipase domain-containing protein 7 isoform 3 (mouse)

A patatin-like phospholipase domain-containing protein 7 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:A2AJ88-3.


PATI_PENEN Cytochrome P450 monooxygenase patI (sprot)


PATH_PENEN Cytochrome P450 monooxygenase patH (sprot)


MPAB2_PENBR ER-bound oxygenase mpaB' (sprot)


MPDE2_PENBR Cytochrome P450 monooxygenase mpaDE' (sprot)


TAP2_HUMAN Antigen peptide transporter 2 (sprot)

An antigen peptide transporter 2 that is encoded in the genome of human.


paired box protein Pax-6 isoform 3 sumoylated 1 (mouse)

A paired box protein Pax-6 isoform 3 sumoylated 1 in mouse. UniProtKB:P63015-3, Lys-91, MOD:01149.


epigenetic programming in the zygotic pronuclei

The global programming of epigenetic modifications in the zygote following fertilization. The paternal genome undergoes active DNA demethylation before the first cell division, while the adjacent maternal genome is protected from this process.


negative regulation of proteasomal ubiquitin-dependent protein catabolic process

Any process that stops, prevents, or reduces the frequency, rate or extent of the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome.


CCND2_HUMAN G1/S-specific cyclin-D2 (sprot)

A G1/S-specific cyclin-D2 that is encoded in the genome of human.


CCND3_HUMAN G1/S-specific cyclin-D3 (sprot)

A G1/S-specific cyclin-D3 that is encoded in the genome of human.


A member of the class of hydroxyindoles that is 1H-indole in which the hydrogen at position 5 has been replaced by a hydroxy group.


female organism

biolink:GrossAnatomicalStructure biolink:AnatomicalEntity biolink:OrganismalEntity biolink:BiologicalEntity biolink:NamedThing biolink:PhysicalEssence biolink:SubjectOfInvestigation biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

Gonochoristic organism that can produce female gametes.


vacuole-mitochondrion membrane contact site

A zone of apposition between the vacuolar membrane and the mitochondrial outer membrane, important for transfer of lipids between the two organelles.


endoplasmic reticulum-vacuole membrane contact site

A zone of apposition between endoplasmic-reticulum and lytic vacuole membranes, structured by bridging complexes.


protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway

The process of directing proteins towards the vacuole that contributes to protein catabolism via the multivesicular body (MVB) pathway.


viral DNA genome replication

The replication of a viral DNA genome.


positive regulation of mitophagy

Any process that activates or increases the frequency, rate or extent of mitophagy.


SPHK2_HUMAN Sphingosine kinase 2 (sprot)

A sphingosine kinase 2 that is encoded in the genome of human.


DEAF1_MOUSE Deformed epidermal autoregulatory factor 1 homolog (sprot)

A deformed epidermal autoregulatory factor 1 that is encoded in the genome of mouse.


ETS1_MOUSE Protein C-ets-1 (sprot)

A protein C-ets-1 that is encoded in the genome of mouse.


PAX7_MOUSE Paired box protein Pax-7 (sprot)

A paired box protein Pax-7 that is encoded in the genome of mouse.


COE3_MOUSE Transcription factor COE3 (sprot)

A transcription factor COE3 that is encoded in the genome of mouse.


COE2_MOUSE Transcription factor COE2 (sprot)

A transcription factor COE2 that is encoded in the genome of mouse.


COE1_MOUSE Transcription factor COE1 (sprot)

A transcription factor COE1 that is encoded in the genome of mouse.


T2FA_MOUSE General transcription factor IIF subunit 1 (sprot)

A general transcription factor IIF subunit 1 that is encoded in the genome of mouse.


IKZF4_MOUSE Zinc finger protein Eos (sprot)

A zinc finger protein Eos that is encoded in the genome of mouse.


PROX1_MOUSE Prospero homeobox protein 1 (sprot)

A prospero homeobox protein 1 that is encoded in the genome of mouse.


zinc finger protein ZFPM2 isoform 1 (mouse)

A zinc finger protein ZFPM2 isoform 1 that is encoded in the genome of mouse.


neural crest formation

The formation of the specialized region of ectoderm between the neural ectoderm (neural plate) and non-neural ectoderm. The neural crest gives rise to the neural crest cells that migrate away from this region as neural tube formation procedes.


regulation of mating-type specific transcription, DNA-templated

Any mating-type specific process that modulates the frequency, rate or extent of cellular DNA-templated transcription.


negative regulation of white fat cell proliferation

Any process that stops or decreases the rate or extent of white fat cell proliferation.


receptor antagonist activity

The activity of a gene product that interacts with a receptor to decrease the ability of the receptor agonist to bind and activate the receptor.


receptor transactivation

The process in which a receptor is activated by another receptor. Receptor transactivation can occur through different mechanisms and includes cross-talk between signaling pathways where one receptor activates a receptor for a different ligand, and also activation of subunits within a receptor oligomer.


Ketoacidosis

biolink:PhenotypicFeature biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:NamedThing biolink:ThingWithTaxon

Acidosis resulting from accumulation of ketone bodies.


secondary heart field specification

The process that results in the delineation of a specific region of the lateral mesoderm into the area which will form the majority of the mesodermal component of the right ventricle, arterial pole (outflow tract) and venous pole (inflow tract).


nuclear receptor corepressor 2

A protein that is a translation product of the human NCOR2 gene or a 1:1 ortholog thereof.


nuclear receptor corepressor 1

A protein that is a translation product of the human NCOR1 gene or a 1:1 ortholog thereof.


peroxisome proliferator-activated receptor alpha

A protein that is a translation product of the human PPARA gene or a 1:1 ortholog thereof.


negative regulation of mesodermal cell fate specification

Any process that stops, prevents, or reduces the frequency, rate or extent of mesoderm cell fate specification.


regulation of double-strand break repair

Any process that modulates the frequency, rate or extent of double-strand break repair.


negative regulation of angiogenesis

Any process that stops, prevents, or reduces the frequency, rate or extent of angiogenesis.


regulation of intrinsic apoptotic signaling pathway by p53 class mediator

Any process that modulates the frequency, rate or extent of intrinsic apoptotic signaling pathway by p53 class mediator.


regulation of oogenesis

Any process that modulates the frequency, rate or extent of oogenesis.


response to X-ray

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of X-ray radiation. An X-ray is a form of electromagnetic radiation with a wavelength in the range of 10 nanometers to 100 picometers (corresponding to frequencies in the range 30 PHz to 3 EHz).


DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator

A cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, resulting in the induction of the transcription of p21 (also known as WAF1, CIP1 and SDI1) or any equivalent protein, in response to the detection of DNA damage.


cellular senescence

A cell aging process stimulated in response to cellular stress, whereby normal cells lose the ability to divide through irreversible cell cycle arrest.


apoptotic process involved in blood vessel morphogenesis

Any apoptotic process that is involved in blood vessel morphogenesis.


positive regulation of cysteine-type endopeptidase activity involved in apoptotic process

Any process that activates or increases the activity of a cysteine-type endopeptidase involved in the apoptotic process.


retrotransposon silencing

Any process that decreases the frequency, rate or extent of retrotransposition. Retrotransposons are a subset of transposable elements that use an RNA intermediate and reverse transcribe themselves into the genome.


negative regulation of cell division

Any process that stops, prevents, or reduces the frequency, rate or extent of cell division.


response to methylmercury

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methylmercury stimulus.


armadillo repeat domain binding

Binding to an armadillo repeat domain, an approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity protein armadillo. Arm-repeat proteins are involved in various processes, including intracellular signaling and cytoskeletal regulation.


muscle cell migration

The orderly movement of a muscle cell from one site to another, often during the development of a multicellular organism.


convergent extension involved in organogenesis

The morphogenetic process in which an epithelium narrows along one axis and lengthens in a perpendicular axis contribution to the shaping of an organ.


SMAD binding

Binding to a SMAD signaling protein.


Spemann organizer formation at the embryonic shield

Formation of the specialized region of the embryonic shield of the embryo that acts as the main signaling center establishing the teleost body plan.


axial mesoderm morphogenesis

The process in which the anatomical structures of the axial mesoderm are generated and organized.


notochord formation

The formation of the notochord from the chordamesoderm. The notochord is composed of large cells packed within a firm connective tissue sheath and is found in all chordates at the ventral surface of the neural tube. In vertebrates, the notochord contributes to the vertebral column.


axial mesodermal cell fate specification

The process in which a cell becomes capable of differentiating autonomously into an axial mesoderm cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed.


photoreceptor cell development

Development of a photoreceptor, a cell that responds to incident electromagnetic radiation, particularly visible light.


post-embryonic retina morphogenesis in camera-type eye

The process in which the anatomical structure of the retina is generated and organized in a camera-type eye during the post-embryonic life stage.


ZRAN1_HUMAN Ubiquitin thioesterase ZRANB1 (sprot)

A ubiquitin thioesterase ZRANB1 that is encoded in the genome of human.


regulation of axonogenesis

Any process that modulates the frequency, rate or extent of axonogenesis, the generation of an axon, the long process of a neuron.


noradrenergic cell

A cell capable of producting norepiniphrine. Norepiniphrine is a catecholamine with multiple roles including as a hormone and a neurotransmitter. In addition, epiniphrine is synthesized from norepiniphrine by the actions of the phenylethanolamine N-methyltransferase enzyme.


motor neuron axon guidance

The process in which the migration of an axon growth cone of a motor neuron is directed to a specific target site in response to a combination of attractive and repulsive cues.


axon arborization

The process in which the terminal anatomical structures of an axon are generated and organized into branches of specialised projections, or boutons. An axon is the long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminal branches.


regulation of neuromuscular junction development

Any process that modulates the frequency, rate or extent of neuromuscular junction development.


regulation of axon extension involved in axon guidance

Any process that modulates the frequency, rate or extent of axon extension involved in axon guidance.


positive regulation of oxidative phosphorylation

Any process that activates or increases the frequency, rate or extent of oxidative phosphorylation.


peripheral nervous system neuron

A neuron that is part of a peripheral nervous system.


basket cell

Basket cells are inhibitory GABAergic interneurons of the brain. In general, dendrites of basket cells are free branching and contain smooth spines. Axons are highly branched. The branched axonal arborizations give rise to basket-like structures that surround the soma of the target cell. Basket cells form axo-somatic synapses, meaning their synapses target somas of other cells.


roundabout homolog 3 isoform ROBO3.2 (mouse)

A roundabout homolog 3 (mouse) that has a unique C-terminal sequence due to retention of the intron between exons 26 and 27.


roundabout homolog 3 isoform ROBO3.1 (mouse)

A roundabout homolog 3 (mouse) that has a C-terminal sequence that includes the region encoded by exons 26, 27 and 28. The resulting 78 amino acid peptide is highly enriched in arginine/serine dipeptide repeats.


reticulon-4 isoform A (mouse)

A reticulon-4 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q99P72-2.


yolk

Nutrient store for embryonic development in the form of semicrystalline phospholipoprotein and contained within yolk granules. Kimmel et al, 1995.


cortical microtubule organization

A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of structures formed of microtubules and associated proteins in the cell cortex, i.e. just beneath the plasma membrane of a cell.


invagination involved in gastrulation with mouth forming second

The infolding of the epithelial sheet into the embryo involved in deuterostomic gastrulation.


negative regulation of beta-catenin-TCF complex assembly

Any process that stops, prevents or reduces the frequency, rate or extent of beta-catenin-TCF complex assembly.


regulation of germ cell proliferation

Any process that modulates the frequency, rate or extent of germ cell proliferation.


yolk syncytial layer development

The progression of the yolk syncytial layer over time, from its initial formation to the mature structure. The yolk syncytial layer is the peripheral layer of the yolk cell including nuclei and non-yolky cytoplasm.


epiboly involved in gastrulation with mouth forming second

The expansion of one cell sheet over other cells involved in deuterostomic gastrulation.


leukocyte activation

A change in morphology and behavior of a leukocyte resulting from exposure to a specific antigen, mitogen, cytokine, cellular ligand, or soluble factor.


connexin complex

An assembly of six molecules of connexin, made in the Golgi apparatus and subsequently transported to the plasma membrane, where docking of two connexons on apposed plasma membranes across the extracellular space forms a gap junction.


spinal cord ependyma

The ependymal cell layer that lines the spinal cord.


voltage-gated channel activity

Enables the transmembrane transfer of a solute by a channel whose open state is dependent on the voltage across the membrane in which it is embedded.


gap junction hemi-channel activity

A wide pore channel activity that enables the transport of a solute across a membrane via a gap junction hemi-channel. Two gap junction hemi-channels coupled together form a complete gap junction.


caudal fin morphogenesis

The process in which the anatomical structures of the caudal fin are generated and organized. A caudal fin is an unpaired medial fin mounted at the caudal end of the fish, and is the main fin used for propulsion.


embryonic skeletal joint morphogenesis

The process in which the anatomical structures of skeletal joints are generated and organized during the embryonic phase. A skeletal joint is the connecting structure between the bones of the skeleton.


cell communication

Any process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment.


medial fin development

The process whose specific outcome is the progression of a medial fin over time, from its formation to the mature structure.


mitotic sister chromatid cohesion

The cell cycle process in which the sister chromatids of a replicated chromosome are joined along the entire length of the chromosome, from their formation in S phase through metaphase during a mitotic cell cycle. This cohesion cycle is critical for high fidelity chromosome transmission.


regulation of protein processing

Any process that modulates the frequency, rate or extent of protein processing, a protein maturation process achieved by the cleavage of a peptide bond or bonds within a protein.


negative regulation of protein processing

Any process that decreases the rate, frequency or extent of protein maturation by peptide bond cleavage.


ADAM3_MOUSE A disintegrin and metallopeptidase domain 3 (sprot)

A protein that is a translation product of the Adam3 gene in mouse.


regulation of protein secretion

Any process that modulates the frequency, rate or extent of the controlled release of a protein from a cell.


negative regulation of protein secretion

Any process that stops, prevents, or reduces the frequency, rate or extent of the controlled release of a protein from a cell.


serine protease inhibitor complex

A heterodimeric protein complex that contains a serine protease inhibitor and a protease; formation of the complex inhibits serine protease activity.


cellular response to BMP stimulus

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a bone morphogenetic protein (BMP) stimulus.


perichondral bone morphogenesis

The process in which bones are generated and organized as a result of the conversion of initial connective tissue surrounding cartilage into bone.