protein phosphatase activator activity

Binds to and increases the activity of a protein phosphatase.


mitochondrial iron-sulfur cluster assembly complex

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A protein complex consisting of frataxin, cysteine desulfurase, an accessory protein and a Fe-S scaffold protein. In human these genes correspond to FXN, NFS1, ISD11 and ISCU respectively. This complex assembles Fe-S clusters onto the scaffolding protein using the substrates ferrous iron, electrons, and sulfur from l-cysteine.


acyl carrier activity

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Binding an acyl group and presenting it for processing or offloading to a cognate enzyme. Covalently binds the acyl group via a phosphopantetheine prosthetic group and mediates protein-protein interactions with the enzyme conferring specificity. The acyl carrier protein (ACP) presents substrates to enzymes involved in fatty acid biosynthesis or in polyketide secondary metabolite biosynthesis.


spermine transport

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The directed movement of spermine, N,N-bis(3-aminopropyl)-1,4-diaminobutane, a polyamine formed by the transfer of a propylamine group from decarboxylated S-adenosylmethionine to spermidine, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


mitochondrial intermembrane space protein transporter complex

Soluble complex of the mitochondrial intermembrane space composed of various combinations of small Tim proteins; acts as a protein transporter to guide proteins to the Tim22 complex for insertion into the mitochondrial inner membrane.


Catalysis of the reaction: 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate = 1-(indol-3-yl)glycerol 3-phosphate + CO2 + H2O.


The process of coupling threonine to threonyl-tRNA in a mitochondrion, catalyzed by threonyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA.


Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: selenite(out) + H+(out) = selenite(in) + H+(in).


secondary active monocarboxylate transmembrane transporter activity

Catalysis of the movement of a monocarboxylate, any compound containing a single carboxyl group (COOH or COO-), by uniport, symport or antiport across a membrane by a carrier-mediated mechanism.


plasma membrane pyruvate transport

The directed movement of pyruvate, 2-oxopropanoate, across a plasma membrane.


plasma membrane lactate transport

The directed movement of lactate across a plasma membrane.


Catalysis of the reaction: (3S)-3-hydroxy-L-aspartate = NH4 + oxaloacetate.


cellular modified amino acid catabolic process

The chemical reactions and pathways resulting in the breakdown of compounds derived from amino acids, organic acids containing one or more amino substituents.


regulation of intracellular transport

Any process that modulates the frequency, rate or extent of the directed movement of substances within cells.


U2-type post-mRNA release spliceosomal complex

A spliceosomal complex that is formed following the release of the spliced product from the post-spliceosomal complex and contains the excised intron and the U2, U5 and U6 snRNPs.


exomer complex

A protein complex that forms a coat structure on vesicles involved in exocytosis of proteins from the trans-Golgi network to the cell surface; in Saccharomyces, the complex contains Chs5p, Chs6p, and Chs6p paralogues.


nitrogen catabolite repression of transcription

A transcription regulation process in which the presence of one nitrogen source leads to a decrease in the frequency, rate, or extent of transcription of specific genes involved in the metabolism of other nitrogen sources.


sedoheptulose-bisphosphatase activity

Catalysis of the reaction: sedoheptulose 1,7-bisphosphate + H2O = sedoheptulose 7-phosphate + phosphate.


ribose phosphate biosynthetic process

The chemical reactions and pathways resulting in the formation of ribose phosphate, any phosphorylated ribose sugar.


phospholipid dephosphorylation

The process of removing one or more phosphate groups from a phosphorylated lipid, any member of a group of substances soluble in lipid solvents but only sparingly soluble in aqueous solvents.


endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

Endonucleolytic cleavage at the 3'-end of the SSU-rRNA from an originally tricistronic rRNA transcript that contained the Small Subunit (SSU) rRNA, the 5.8S rRNA, and the Large Subunit (LSU) rRNA in that order from 5' to 3' along the primary transcript, to produce the mature end of the SSU-rRNA.


maturation of 5.8S rRNA

Any process involved in the maturation of a precursor 5.8S ribosomal RNA (rRNA) molecule into a mature 5.8S rRNA molecule.


Catalysis of the reaction: 2 S-adenosyl-L-methionine + uroporphyrin III = 2 S-adenosyl-L-homocysteine + precorrin-2.


negative regulation of hydrogen peroxide-mediated programmed cell death

Any process that stops, prevents or reduces the frequency, rate or extent of hydrogen peroxide-mediated programmed cell death.


3'-tRNA processing endoribonuclease activity

Catalysis of the endonucleolytic cleavage of RNA, removing extra 3' nucleotides from tRNA precursor, generating 3' termini of tRNAs. A 3'-hydroxy group is left at the tRNA terminus and a 5'-phosphoryl group is left at the trailer molecule.


purine nucleobase biosynthetic process

The chemical reactions and pathways resulting in the formation of purine nucleobases, one of the two classes of nitrogen-containing ring compounds found in DNA and RNA, which include adenine and guanine.


assembly of large subunit precursor of preribosome

The aggregation, arrangement and bonding together of a set of components to form the large subunit precursor of the preribosome.


Dom34-Hbs1 complex

A protein complex consisting of one subunit known as Dom34 or Pelota that has similarity to translation termination factor eRF1, and another subunit, Hbs1, that is a GTPase with similarity to translation termination factor eRF3. The Dom34-Hbs1 complex has a role in cotranslational mRNA quality control by promoting ribosomal subunit dissociation and peptidyl-tRNA release when translation is stalled, facilitating no-go decay and nonstop decay.


snRNA modification

The covalent alteration of one or more nucleotides within snRNA, resulting in a change in the properties of the snRNA.


RNA exon ligation

The RNA metabolic process that joins two exons, each of which has free ends that were generated by endonucleolytic cleavages, by a ligation reaction.


snRNA metabolic process

The chemical reactions and pathways involving snRNA, small nuclear RNA, any of various low-molecular-mass RNA molecules found in the eukaryotic nucleus as components of the small nuclear ribonucleoprotein.


mitochondrial protein catabolic process

The chemical reactions and pathways resulting in the breakdown of a mitochondrial protein. This process is necessary to maintain the healthy state of mitochondria and is thought to occur via the induction of an intramitochondrial lysosome-like organelle that acts to eliminate the damaged oxidised mitochondrial proteins without destroying the mitochondrial structure.


dipeptide transmembrane transporter activity

Enables the transfer of a dipeptide from one side of a membrane to the other. A dipeptide is a combination of two amino acids linked together by a peptide (-CO-NH-) bond.


tripeptide transmembrane transporter activity

Enables the transfer of a tripeptide, a compound containing three amino acids linked together by peptide bonds, from one side of a membrane to the other.


dipeptide transport

The directed movement of a dipeptide, a combination of two amino acids by means of a peptide (-CO-NH-) link, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


tripeptide transport

The directed movement of a tripeptide, a compound containing three amino acids linked together by peptide bonds, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


pyridoxine metabolic process

The chemical reactions and pathways involving pyridoxine, 2-methyl-3-hydroxy-4,5-bis(hydroxymethyl)pyridine, one of the vitamin B6 compounds. Pyridoxal, pyridoxamine and pyridoxine are collectively known as vitamin B6, and are efficiently converted to the biologically active form of vitamin B6, pyridoxal phosphate.


glycerone kinase activity

Catalysis of the reaction: ATP + glycerone = ADP + glycerone phosphate + 2 H+.


glycerol to glycerone phosphate metabolic process

The chemical reactions and pathways in which glycerol, 1,2,3-propanetriol, is converted to glycerone phosphate.


clathrin-coated vesicle cargo loading

Formation of a macromolecular complex between the cytoplasmic coat proteins on clathrin-coated vesicles and proteins and/or lipoproteins that are going to be transported by a vesicle.


mitochondrial DNA-directed RNA polymerase complex

A DNA-directed RNA polymerase complex located in the mitochondrion. Mitochondrial RNA polymerase is composed of two subunits, a catalytic core, which resembles the enzymes from bacteriophage T7 and T3, and a specificity factor required for promoter recognition, which is similar to members of the eubacterial sigma factor family. In S. cerevisiae, these are encoded by the nuclear genes RPO41 and MTF1 and the specificity factor, required for promoter recognition and initiation, is not present in the elongating form.


transcription elongation by mitochondrial RNA polymerase

The extension of an RNA molecule after transcription initiation and promoter clearance at mitochondrial promoter by the addition of ribonucleotides catalyzed by a mitchondrial RNA polymerase.


Golgi vesicle budding

The evagination of the Golgi membrane, resulting in formation of a vesicle.


pre-mRNA catabolic process

The chemical reactions and pathways resulting in the breakdown of the unspliced pre-mRNA (pre-messenger RNA).


COPII-coated vesicle budding

The evagination of an endoplasmic reticulum membrane, resulting in formation of a COPII-coated vesicle.


cyclin-dependent protein kinase activating kinase activity

Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein; increases the activity of a cyclin-dependent protein kinase (CDK).


phosphatidylinositol deacylase activity

Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol + H2O = 1-acyl-sn-glycero-3-phospho-D-myo-inositol + a carboxylate + H+.


protein-lipid complex remodeling

The acquisition, loss or modification of a protein or lipid within a protein-lipid complex.


aminoacyl-tRNA editing activity

The hydrolysis of an incorrectly aminoacylated tRNA.


nitrogen catabolite activation of transcription

A transcription regulation process in which the presence of one nitrogen source leads to an increase in the frequency, rate, or extent of transcription of specific genes involved in the metabolism of other nitrogen sources.


valine catabolic process

The chemical reactions and pathways resulting in the breakdown of valine, 2-amino-3-methylbutanoic acid.


leucine catabolic process

The chemical reactions and pathways resulting in the breakdown of leucine, 2-amino-4-methylpentanoic acid.


proteasome core complex import into nucleus

The directed movement of the proteasome core complex (AKA core particle (CP)) from the cytoplasm into the nucleus.


MutSgamma complex

A heterodimer involved in the stabilization of DNA recombination intermediates, the promotion of crossover recombination, and the proper assembly of the synaptonemal complex in meiotic prophase nuclei. In yeast the complex consists of two subunits, Msh4 and Msh5.


nuclear pore linkers

A substructure of the nuclear pore complex (NPC) that serves to connect members of the central transport channel (composed of FG-nucleoporins) to the core scaffold (composed of the inner and outer NPC rings). In S. cerevisiae, the linkers are Nic96p and Nup82p. In vertebrates, they are Nup93 and Nup88. Components are arranged in 8-fold symmetrical 'spokes' around the central transport channel. Both linkers can be isolated in association with specific FG-nucleoporins, complexes that are sometimes referred to as the Nic96 complex (Nic96p-Nsp1p-Nup49p-Nup57p) and the Nup82 complex (Nup82p-Nup116p-Nup159p-Gle2p).


PAS complex

A class III phosphatidylinositol 3-kinase complex that contains a phosphatidylinositol-3-phosphate 5-kinase subunit (Fab1p in yeast; PIKfyve in mammals), a kinase activator, and a phosphatase, and may also contain additional proteins; it is involved in regulating the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate. In mammals the complex is composed of PIKFYVE, FIG4 and VAC14. In yeast it is composed of Atg18p, Fig4p, Fab1p, Vac14p and Vac7p.


positive regulation of vacuole organization

Any process that activates or increases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a vacuole.


sulfite reductase complex (NADPH)

A multisubunit iron flavoprotein, which in yeast is composed of 2 alpha and 2 beta subunits. Catalyzes the reduction of sulfite to sulfide.


sulfite reductase (NADPH) activity

Catalysis of the reaction: hydrogen sulfide + 3 NADP+ + 3 H2O = sulfite + 3 NADPH + 3 H+.


negative regulation of meiotic DNA double-strand break formation

Any process that stops, prevents or reduces the frequency, rate or extent of meiotic DNA double-strand break formation.


half bridge of spindle pole body

Structure adjacent to the plaques of the spindle pole body.


negative regulation of kinetochore assembly

Any process that stops, prevents or reduces the frequency, rate or extent of kinetochore assembly.


fructose import across plasma membrane

The directed movement of fructose substance from outside of a cell, across the plasma membrane and into the cytosol.


L-cysteine catabolic process to pyruvate

The chemical reactions and pathways resulting in the breakdown of L-cysteine into other compounds, including pyruvate.


protein-transporting ATPase activity

Primary active carrier-mediated transport of a protein across a membrane, driven by the hydrolysis of the diphosphate bond of inorganic pyrophosphate, ATP, or another nucleoside triphosphate. The transport protein may or may not be transiently phosphorylated, but the substrate is not phosphorylated.


proteasome-activating activity

Catalysis of the reaction: ATP + H2O = ADP + phosphate, which promotes unfolding of protein substrates, and channel opening of the core proteasome.


rRNA methyltransferase activity

Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a nucleoside residue in an rRNA molecule.


histone H2AQ104 methyltransferase activity

Catalysis of the reaction: S-adenosyl-L-methionine + (histone H2A)-glutamine (position 104) = S-adenosyl-L-homocysteine + (histone H2A)-N5-methyl-glutamine (position 104). Note that this corresponds to  Q105 in yeast.


box C/D RNA 3'-end processing

Any process involved in forming the mature 3' end of a box C/D RNA molecule.


intracellular accumulation of glycerol

The accumulation of glycerol within a cell, for example by increased glycerol biosynthesis combined with decreased permeability of the cell membrane to glycerol, in response to the detection of a hyperosmotic environment.


mitochondrial tRNA wobble position uridine thiolation

The process in which a uridine residue at position 34 in the anticodon of a mitochondrial tRNA is post-transcriptionally thiolated at the C2 position. This process involves transfer of a sulfur from cysteine to position C2 by several steps.


positive regulation of microtubule nucleation

Any process that increases the rate, frequency or extent of microtubule nucleation. Microtubule nucleation is the 'de novo' formation of a microtubule, in which tubulin heterodimers form metastable oligomeric aggregates, some of which go on to support formation of a complete microtubule. Microtubule nucleation usually occurs from a specific site within a cell.


FAD biosynthetic process

The chemical reactions and pathways resulting in the formation of FAD, the oxidized form of flavin-adenine dinucleotide.


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detection of sucrose stimulus

The series of events in which a sucrose stimulus is received by a cell and converted into a molecular signal.


sucrose mediated signaling

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The series of molecular signals mediated by the detection of sucrose.


NADH regeneration

A metabolic process that generates a pool of NADH by the reduction of NAD+.


peroxisome membrane targeting sequence binding

Binding to a peroxisomal membrane targeting sequence, any of several sequences of amino acids within a protein that can act as a signal for the localization of the protein into the peroxisome membrane.


ER-dependent peroxisome organization

A process of peroxisome organization in which assembly or arrangement of constituent parts takes place in the endoplasmic reticulum.


NADH dehydrogenase activity

Catalysis of the reaction: NADH + H+ + acceptor = NAD+ + reduced acceptor.


carboxymethylenebutenolidase activity

Catalysis of the reaction: 4-carboxymethylenebut-2-en-4-olide + H2O = 4 oxohex-2-enedioate.


dolichyl-phosphate-mannose-protein mannosyltransferase Pmt5p-Pmt3p dimer complex

A protein dimer complex that possesses dolichyl-phosphate-mannose-protein mannosyltransferase activity and, in S. cerevisiae, is composed of Pmt5p-Pmt3p.


dolichyl-phosphate-mannose-protein mannosyltransferase Pmt1p-Pmt3p dimer complex

A protein dimer complex that possesses dolichyl-phosphate-mannose-protein mannosyltransferase activity and, in S. cerevisiae, is composed of Pmt1p-Pmt3p.


regulation of SNARE complex assembly

Any process that modulates the frequency, rate or extent of assembly of the SNARE complex. The SNARE complex is a protein complex involved in membrane fusion; a stable ternary complex consisting of a four-helix bundle, usually formed from one R-SNARE and three Q-SNAREs with an ionic layer sandwiched between hydrophobic layers.


regulation of purine nucleobase metabolic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving purines.


regulation of histidine biosynthetic process

Any process that modulates the frequency, rate or extent of histidine biosynthetic process.


transcription factor TFIIK complex

A transcription factor complex that forms part of the holo TFIIH complex. In Saccharomyces/human, TFIIK contains Ccl1p/Cyclin H, Tfb3p/MAT1 and Kin28p/CDK7.


recruitment of 3'-end processing factors to RNA polymerase II holoenzyme complex

The process in which proteins required for 3'-end transcript processing become associated with the RNA polymerase II holoenzyme complex and the 3' end of a transcript.


recruitment of mRNA capping enzyme to RNA polymerase II holoenzyme complex

The process in which the guanylyltransferase enzyme responsible for adding a 7-methylguanosine cap on pre-mRNA becomes associated with the RNA polymerase II holoenzyme complex and the 5' end of a transcript.


secondary cell septum biogenesis

A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a secondary cell septum following nuclear division.


glycine import into mitochondrion

The process in which glycine is transported from the cytosol into the mitochondrial matrix.


iron chaperone activity

Directly binding to and delivering iron ions to a target protein.


alpha-keto amide reductase activity

Catalysis of the reaction: alpha-keto amide + 2 H+ (from donor) = (R)-hydroxy amide. Alpha-keto amides are of the form R-CO-CONH2, where R may be aromatic or aliphatic.


alpha-keto ester reductase activity

Catalysis of the reaction: alpha-keto ester + 2 H+ (from donor) = (R)-hydroxy ester. Alpha-keto esters are of the form R(1)-CO-CO-O-R(2), where the R groups may be aromatic or aliphatic.


cellular ketone metabolic process

The chemical reactions and pathways involving any of a class of organic compounds that contain the carbonyl group, CO, and in which the carbonyl group is bonded only to carbon atoms, as carried out by individual cells. The general formula for a ketone is RCOR, where R and R are alkyl or aryl groups.


amide metabolic process

The chemical reactions and pathways involving an amide, any derivative of an oxoacid in which an acidic hydroxy group has been replaced by an amino or substituted amino group, as carried out by individual cells.


homocitrate synthase activity

Catalysis of the reaction: 2-oxoglutarate + acetyl-CoA + H2O = CoA + H+ + homocitrate.


RAVE complex

A multisubunit complex that in Saccharomyces is composed of three subunits, Rav1p, Rav2p and Skp1p. Acts transiently to catalyze assembly of cytoplasmic V1, with membrane embedded V0 to form the V-ATPase holoenzyme.


negative regulation of mitochondrial fusion

Any process that decreases the frequency, rate or extent of merging of two or more mitochondria within a cell to form a single compartment.


positive regulation of glycolytic fermentation to ethanol

Any process that activates or increases the frequency, rate or extent of glucose catabolic process to ethanol.


Catalysis of the reaction: adenosine 5'-monophosphoramidate + H2O = AMP + NH4+. Other substrates include AMP-morpholidate, AMP-N-alanine methyl ester and AMP-alpha-acetyl lysine methyl ester.


Catalysis of the reaction: ATP + biotin + apo-(pyruvate-carboxylase) = AMP + diphosphate + biotin-(pyruvate-carboxylase).


Catalysis of the reaction: ATP + biotin + apo-(acetyl-CoA:carbon-dioxide ligase (ADP forming)) = AMP + diphosphate + (acetyl-CoA:carbon-dioxide ligase (ADP forming)).


Noc4p-Nop14p complex

A heterodimer associated with precursors of the eukaryotic small ribosomal subunit, including the 90S preribosome; involved in small subunit biogenesis.


phosphatidic acid transfer activity

Removes a phosphatidic acid from a membrane or a monolayer lipid particle, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to an acceptor membrane or lipid particle. Phosphatidic acid refers to a glycophospholipids with, in general, a saturated fatty acid bonded to carbon-1, an unsaturated fatty acid bonded to carbon-2, and a phosphate group bonded to carbon-3.


lactate catabolic process

The chemical reactions and pathways resulting in the breakdown of lactate.


Pho85-Pho80 CDK-cyclin complex

A cyclin dependent kinase (CDK) complex that contains a kinase subunit and a regulatory cyclin subunit. An example of this complex in budding yeast S. cerevisiae consists of the Pho85 kinase and the Pho80 cyclin.


negative regulation of calcium-mediated signaling

Any process that stops, prevents, or reduces the frequency, rate or extent of calcium-mediated signaling.


negative regulation of phosphate metabolic process

Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving phosphates.


hydroxymethylfurfural reductase (NADH) activity

Catalysis of the reaction: 5-hydroxymethylfurfural + NADH + H+ = 2,5-bis-hydroxymethylfuran + NAD+.


furaldehyde metabolic process

The chemical reactions and pathways involving furaldehyde, a furan ring-containing aldehyde compound which can be formed from the thermal decomposition of biomass.


guanine nucleotide transport

The directed movement of guanine nucleotides, GTP, GDP, and/or GMP, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


tRNA (m7G46) methyltransferase complex

A protein complex involved in the catalysis of the formation of the modified nucleotide 7-methylguanine (at position 46 in certain tRNAs, such as tRNA(phe) and tRNA(met). In yeast, it is a heterotetramer of two subunits, Trm8 (catalytic) and Trm82 (WD repeat).


endoplasmic reticulum tubular network maintenance

The organization process that preserves the endoplasmic reticulum (ER) tubular network in a stable functional or structural state. The ER tubular network is the ER part that comprises the membranes with high curvature in cross-section.


inositol hexakisphosphate binding

Binding to inositol hexakisphosphate.


D-tyrosyl-tRNA(Tyr) deacylase activity

Catalysis of the reaction: D-tyrosyl-tRNA(Tyr) = D-tyrosine + tRNA(Tyr). Hydrolysis of the removal of D-tyrosine from tyrosine residues in charged tRNA.


D-leucyl-tRNA(Leu) deacylase activity

Catalysis of the reaction: D-leucyl-tRNA(Leu) = D-leucine + tRNA(Leu). Hydrolysis of the removal of D-leucine from residues in charged tRNA(Leu).


D-tyrosine catabolic process

The chemical reactions and pathways resulting in the breakdown of D-tyrosine.


tRNA metabolic process

The chemical reactions and pathways involving tRNA, transfer RNA, a class of relatively small RNA molecules responsible for mediating the insertion of amino acids into the sequence of nascent polypeptide chains during protein synthesis. Transfer RNA is characterized by the presence of many unusual minor bases, the function of which has not been completely established.


D-leucine catabolic process

The chemical reactions and pathways resulting in the breakdown of D-leucine.


division septum assembly

The assembly and arrangement of a septum that spans the plasma membrane interface between progeny cells following cytokinesis. The progeny cells that form a division septum are not able to exchange intracellular material.


phosphoglycolate phosphatase activity

Catalysis of the reaction: 2-phosphoglycolate + H2O = glycolate + phosphate.


xylitol transmembrane transport

The directed movement of a xylitol across a membrane. Xylitol is a polyalcohol (pentane-1,2,3,4,5-pentol), produced by hydrogenation of xylose.


RNA polymerase III core binding

Binding to an RNA polymerase III core enzyme, a multisubunit eukaryotic nuclear RNA polymerase typically composed of seventeen subunits.


Catalysis of the reaction: N-(5-phospho-beta-D-ribosyl)anthranilate = 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate.


GINS complex

A heterotetrameric protein complex that associates with replication origins, where it is required for the initiation of DNA replication, and with replication forks.


negative regulation of maintenance of mitotic sister chromatid cohesion

Any process that decreases the extent to which the association between sister chromatids of a replicated chromosome is maintained during a mitotic cell cycle.


regulation of inositol phosphate biosynthetic process

Any process that modulates the rate, frequency or extent of inositol phosphate biosynthesis. Inositol phosphate biosynthetic processes are the chemical reactions and pathways resulting in the formation of an inositol phosphate, 1,2,3,4,5,6-cyclohexanehexol, with one or more phosphate groups attached.


FAL1-SGD1 complex

A protein complex involved in the 18S rRNA biogenesis. In S. cerevisiae this complex consists of Fal1p and Sgd1p and in humans this complex consists of NOM1 and eIF4AIII subunits.


positive regulation of lysine biosynthetic process via alpha-aminoadipate and saccharopine

Any process that activates or increases the frequency, rate or extent of lysine biosynthetic process via alpha-aminoadipate and saccharopine.


oligosaccharide binding

Binding to an oligosaccharide, a molecule with between two and (about) 20 monosaccharide residues connected by glycosidic linkages.


mitochondrial tRNA 5'-end processing

The process in which the 5' end of a pre-tRNA molecule is converted to that of a mature tRNA in the mitochondrion.


trehalose metabolism in response to stress

The chemical reactions and pathways involving trehalose that occur as a result of a stimulus indicating the organism is under stress.


ubiquitin conjugating enzyme complex

Any complex that possesses ubiquitin conjugating enzyme activity.


iron-sulfur cluster binding

Binding to an iron-sulfur cluster, a combination of iron and sulfur atoms.


single base insertion or deletion binding

Binding to a double-stranded DNA region containing a single base insertion or deletion.


D-ribulokinase activity

Catalysis of the reaction: ATP + D-ribulose = ADP + D-ribulose 5-phosphate.


rDNA spacer replication fork barrier binding

Binding to replication fork barriers found in rDNA spacers, sites that inhibit replication forks in the direction opposite to rDNA transcription.


replication fork arrest at rDNA repeats

A process that impedes the progress of the DNA replication fork at natural replication fork pausing sites within the eukaryotic rDNA repeat spacer.


positive regulation of DNA recombination

Any process that activates or increases the frequency, rate or extent of DNA recombination.


Catalysis of the reaction: 3-phosphoshikimate + phosphoenolpyruvate = 5-O-(1-carboxyvinyl)-3-phosphoshikimate + phosphate.


3-dehydroquinate dehydratase activity

Catalysis of the reaction: 3-dehydroquinate = 3-dehydroshikimate + H2O.


shikimate 3-dehydrogenase (NADP+) activity

Catalysis of the reaction: shikimate + NADP+ = 3-dehydroshikimate + NADPH + H+.


3-dehydroquinate synthase activity

Catalysis of the reaction: 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate = 3-dehydroquinate + phosphate.


shikimate kinase activity

Catalysis of the reaction: ATP + shikimate = 3-phosphoshikimate + ADP + 2 H+.


positive regulation of IRE1-mediated unfolded protein response

Any process that activates or increases the frequency, rate or extent of the IRE1-mediated unfolded protein response.


Ric1-Rgp1 guanyl-nucleotide exchange factor complex

A protein complex that acts as a nucleotide exchange factor for the GTPase Ypt6p, and is required for fusion of endosome-derived vesicles with the Golgi.


cyclosporin A binding

Binding to cyclosporin A, a cyclic undecapeptide that contains several N-methylated and unusual amino acids.


clathrin vesicle coat

A clathrin coat found on a vesicle.


Catalysis of the reaction: succinyl-CoA + dihydrolipoamide = CoA + S-succinyldihydrolipoamide.


positive regulation of vesicle fusion

Any process that activates or increases the frequency, rate or extent of vesicle fusion.


Catalysis of the reaction: D-myo-inositol 1,4,5-trisphosphate + ATP = D-myo-inositol 1,4,5,6-tetrakisphosphate + ADP + 2 H+.


regulation of arginine catabolic process

Any process that modulates the frequency, rate or extent of arginine catabolic process.


regulation of arginine biosynthetic process

Any process that modulates the frequency, rate or extent of arginine biosynthetic process.


SAS acetyltransferase complex

A protein complex that possesses histone acetyltransferase activity and links histone acetylation to the assembly of transcriptionally silent chromatin. In vitro, the complex acetylates lysine 16 of histone H4 and lysine 14 of histone H3, although the latter may not be relevant in vivo. The complex contains a catalytic subunit and at least two other subunits; in Saccharomyces, the catalytic subunit is Sas2p and additional subunits are Sas4p and Sas5p.


positive regulation of SNARE complex assembly

Any process that increases the frequency, rate or extent of assembly of the SNARE complex. The SNARE complex is a protein complex involved in membrane fusion; a stable ternary complex consisting of a four-helix bundle, usually formed from one R-SNARE and three Q-SNAREs with an ionic layer sandwiched between hydrophobic layers.


short-chain fatty acid metabolic process

The chemical reactions and pathways involving a fatty acid with an aliphatic tail of less than 6 carbons.


RNA strand annealing activity

An activity that facilitates the formation of a complementary double-stranded RNA molecule.


Group II intron splicing

The splicing of Group II introns. This occurs by a ribozymic mechanism where the intron sequence forms a distinct 3D structure, characteristic of Group II introns and containing splice site consensus sequences, that is involved in catalyzing the splicing reactions, though protein factors are also required in vivo. Splicing occurs by a series of two transesterification reactions (mechanistically similar to those for splicing of nuclear mRNAs) initiated by a bulged adenosine residue within the intron sequence as the initiating nucleophile. The intron is excised as a lariat.


spore germination

The physiological and developmental changes that occur in a spore following release from dormancy up to the earliest signs of growth (e.g. emergence from a spore wall).


nitrogen catabolite repression of transcription from RNA polymerase II promoter

A transcription regulation process in which the presence of one nitrogen source leads to a decrease in the frequency, rate, or extent of transcription, from an RNA polymerase II promoter, of specific genes involved in the metabolism of other nitrogen sources.


negative regulation of cellular response to amino acid starvation

Any process that stops, prevents or reduces the frequency, rate or extent of a cellular response to amino acid starvation.


negative regulation of DNA strand resection involved in replication fork processing

Any process that stops, prevents, or reduces the frequency, rate or extent of DNA strand resection involved in replication fork processing.


histone crotonyltransferase activity

Catalysis of the reaction: crotonyl-CoA + histone = CoA + crotonyl-histone.


positive regulation of heterochromatin formation

Any process that activates or increases the frequency, rate or extent of heterochromatin formation.


FMN biosynthetic process

The chemical reactions and pathways resulting in the formation of FMN, the oxidized form of flavin mononucleotide (riboflavin 5'-(dihydrogen phosphate)), which acts as a coenzyme for a number of oxidative enzymes including NADH dehydrogenase.


homoaconitate hydratase activity

Catalysis of the reaction: (-)-homoisocitrate = cis-homoaconitate + H2O.


gluconokinase activity

Catalysis of the reaction: D-gluconate + ATP = 6-phospho-D-gluconate + ADP + 2 H+.


Catalysis of the successive hydrolysis of beta-D-glucose units from the non-reducing ends of (1->3)-beta-D-glucans, releasing alpha-glucose.


5'-3' DNA exonuclease activity

Catalysis of the sequential cleavage of mononucleotides from a free 5' terminus of a DNA molecule.


anaphase-promoting complex assembly

The aggregation, arrangement and bonding together of a set of components to form an anaphase-promoting complex.


regulation of G1 to G0 transition

Any process that modulates the frequency, rate or extent of G1 to G0 transition.


HDA1 complex

A tetrameric histone deacetylase complex that contains a Class II deacetylase catalytic subunit. In S. cerevisiae it is composed of two Hda1p subunits along with Hda2p and Hda3p.


negative regulation of transcription by competitive promoter binding

Any process that stops, prevents, or reduces the frequency, rate or extent of DNA-dependent transcription using a mechanism that involves direct competition for interaction with a promoter binding site.


asparagine catabolic process

The chemical reactions and pathways resulting in the breakdown of asparagine, 2-amino-3-carbamoylpropanoic acid.


cytoplasmic side of endosome membrane

The side (leaflet) of the endosome membrane that faces the cytoplasm.


snoRNA localization

Any process in which small nucleolar RNA is transported to, or maintained in, a specific location.


proton-transporting two-sector ATPase complex assembly

The aggregation, arrangement and bonding together of a proton-transporting two-sector ATPase complex, a large protein complex that catalyzes the synthesis or hydrolysis of ATP by a rotational mechanism, coupled to the transport of protons across a membrane.


mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)

All non-F1 subunits of the mitochondrial hydrogen-transporting ATP synthase, including integral and peripheral mitochondrial inner membrane proteins.


RNA polymerase III general transcription initiation factor activity

A general transcription initiation factor activity that contributes to transcription start site selection and transcription initiation of genes transcribed by RNA polymerase III. Factors required for RNA polymerase III transcription initiation include TFIIIA, TFIIIB and TFIIIC. RNA polymerase III transcribes genes encoding short RNAs, including tRNAs, 5S rRNA, U6 snRNA, the short ncRNA component of RNases P, the mitochondrial RNA processing (MRP) RNA, the signal recognition particle SRP RNA, and in higher eukaryotes a number of micro and other small RNAs, though there is some variability across species as to whether a given small noncoding RNA is transcribed by RNA polymerase II or RNA polymerase III.


inositol phosphoceramide synthase regulator activity

Binds to and modulates the activity of inositol phosphoceramide synthase.


Catalysis of the reaction: N-(5-phospho-beta-D-ribosyl)anthranilate + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + anthranilate.


NADPH-adrenodoxin reductase activity

Catalysis of the reaction: oxidized adrenodoxin + NADPH + H+ = reduced adrenodoxin + NADP+.


phenylpyruvate decarboxylase activity

Catalysis of the reaction: phenylpyruvate = phenylacetaldehyde + CO2.


branched-chain amino acid catabolic process to alcohol via Ehrlich pathway

The chemical reactions and pathways involving the catabolism of branched chain amino acids to produce branched chain alcohols with one carbon less than the starting amino acid. In S. cerevisiae, this is known to occur for leucine, isoleucine, valine, methionine, phenylalanine, tyrosine, or tryptophan. When a branched chain family amino acid, leucine, isoleucine, or valine, is used as the substrate, 3-methylbutanol, 2-methylbutanol, or 2-methylpropanol, respectively, is produced. Often referred to as the Ehrlich pathway, these reactions generally occur during fermentation to produce a variety of alcohols, often collectively referred to as fusel alcohols. Depending on the redox state of the cells, carboxylic acid derivatives may be produced instead of alcohols.


methionine catabolic process to 3-methylthiopropanol

The chemical reactions and pathways involving the catabolism of branched chain amino acids to produce branched chain alcohols with one carbon less than the starting amino acid. In S. cerevisiae, this is known to occur for leucine, isoleucine, valine, methionine, phenylalanine, tyrosine, or tryptophan. When methionine is used as the substrate, 3-methylthiopropanol is produced. Often referred to as the Ehrlich pathway, these reactions generally occur during fermentation to produce a variety of alcohols, often collectively referred to as fusel alcohols. Depending on the redox state of the cells, carboxylic acid derivatives may be produced instead of alcohols.


SUMO activating enzyme complex

A conserved heterodimeric complex with SUMO activating enzyme activity.


uridine nucleosidase activity

Catalysis of the reaction: H2O + uridine = ribofuranose + uracil.


nicotinic acid riboside hydrolase activity

Catalysis of the reaction: nicotinic acid riboside + H2O = nicotinic acid + D-ribose.


nicotinamide riboside hydrolase activity

Catalysis of the reaction: nicotinamide riboside + H2O = nicotinamide + D-ribose.


ribosylpyrimidine nucleosidase activity

Catalysis of the reaction: an N-D-ribosylpyrimidine + H2O = D-ribose + a pyrimidine.


uridine catabolic process

The chemical reactions and pathways resulting in the breakdown of uridine, uracil riboside, a ribonucleoside very widely distributed but occurring almost entirely as phosphoric esters in ribonucleotides and ribonucleic acids.


nicotinate nucleotide salvage

The generation of nicotinate nucleotide without de novo synthesis.


cytidine catabolic process

The chemical reactions and pathways resulting in the breakdown of cytidine, cytosine riboside, a widely distributed nucleoside.


regulation of RNA polymerase II transcription preinitiation complex assembly

Any process that modulates the frequency, rate or extent of RNA polymerase II transcriptional preinitiation complex assembly.


septin ring disassembly

The controlled breakdown of a septin ring.


adenine biosynthetic process

The chemical reactions and pathways resulting in the formation of adenine, 6-aminopurine, one of the five main bases found in nucleic acids and a component of numerous important derivatives of its corresponding ribonucleoside, adenosine.


aromatic amino acid family catabolic process

The chemical reactions and pathways resulting in the breakdown of aromatic amino acid family, amino acids with aromatic ring (phenylalanine, tyrosine, tryptophan).


histone H3K79 methyltransferase activity

Catalysis of the reaction: S-adenosyl-L-methionine + histone H3 L-lysine (position 79) = S-adenosyl-L-homocysteine + histone H3 N6-methyl-L-lysine (position 79). This reaction is the addition of a methyl group to the lysine residue at position 79 of the histone H3 protein.


endopolyphosphatase activity

Catalysis of the reaction: polyphosphate + n H2O = (n+1) oligophosphate. The product contains 4 or 5 phosphate residues.


GDP biosynthetic process

The chemical reactions and pathways resulting in the formation of GDP, guanosine 5'-diphosphate.


CAAX-box protein processing

The second process in a series of specific posttranslational modifications to the CAAX box region of CAAX box proteins, in which the last three amino acids of the protein (AAX) are removed by proteolysis.


spliceosomal conformational changes to generate catalytic conformation

Structural rearrangements of the spliceosome complex, containing RNA to be spliced, to generate a catalytic conformation.


protein arginine N5-methyltransferase activity

Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to the delta-nitrogen atom of peptidyl-arginine residues. The reaction is S-adenosyl-L-methionine + [protein]-L-arginine = S-adenosyl-L-homocysteine + [protein]-N5-methyl-L-arginine.


plasmid partitioning

Any process in which plasmids are segregated or distributed into daughter cells upon cell division.


Catalysis of the reaction: D-ribulose 5-phosphate = (2S)-2-hydroxy-3-oxobutyl phosphate + formate + H+.


myo-inositol transmembrane transporter activity

Enables the transfer of myo-inositol from one side of a membrane to the other. Myo-inositol is 1,2,3,4,5/4,6-cyclohexanehexol, a growth factor for animals and microorganisms.


positive regulation of mitotic actomyosin contractile ring contraction

Any process that activates or increases the frequency, rate or extent of mitotic actomyosin contractile ring contraction.


carbon utilization

A series of processes that forms an integrated mechanism by which a cell or an organism detects the depletion of primary carbon sources and then activates genes to scavenge the last traces of the primary carbon source and to transport and metabolize alternative carbon sources such as carbon dioxide or carbonic acid. The utilization process begins when the cell or organism detects carbon levels, includes the activation of genes whose products detect, transport or metabolize carbon-containing substances, and ends when carbon is incorporated into the cell or organism's metabolism.


long-chain fatty acyl-CoA binding

Binding to a long-chain fatty acyl-CoA, any derivative of coenzyme A in which the sulfhydryl group is in a thioester linkage with a long-chain fatty-acyl group. A long-chain fatty acid is a fatty acid with an aliphatic tail of 13 to 21 carbons.


uracil catabolic process

The chemical reactions and pathways resulting in the breakdown of uracil, 2,4-dioxopyrimidine, one of the pyrimidine bases occurring in RNA, but not in DNA.


glyoxalase III activity

Catalysis of the reaction: methylglyoxal + H2O = D-lactate.


Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + H+(out) = solute(in) + H+(in).


aromatic compound catabolic process

The chemical reactions and pathways resulting in the breakdown of aromatic compounds, any substance containing an aromatic carbon ring.


cinnamic acid catabolic process

The chemical reactions and pathways resulting in the breakdown of cinnamic acid, 3-phenyl-2-propenoic acid.


ferulate metabolic process

The chemical reactions and pathways involving ferulate, (2E)-3-(4-hydroxy-3-methoxyphenyl)prop-2-enoate.


aldehyde dehydrogenase (NADP+) activity

Catalysis of the reaction: an aldehyde + NADP+ + H2O = an acid + NADPH + H+.


fatty acid alpha-oxygenase activity

Catalysis of the reaction: O2 + a 2,3,4-saturated fatty acid <=> a 2(R)-hydroperoxy fatty acid.


sphingoid catabolic process

The chemical reactions and pathways resulting in the breakdown of sphingoids, any of a class of compounds comprising sphinganine and its homologues and stereoisomers, and derivatives of these compounds.


proteasome core complex, alpha-subunit complex

The proteasome core subcomplex that constitutes the two outer rings of the proteasome core complex. An example of this component is found in Mus musculus.


3-isopropylmalate dehydratase activity

Catalysis of the reaction: (2R,3S)-3-isopropylmalate = (2S)-2-isopropylmalate.


tryptophan synthase activity

Catalysis of the reaction: L-serine + (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate = L-tryptophan + glyceraldehyde 3-phosphate + H2O.


mRNA cleavage stimulating factor complex

A protein complex required for mRNA cleavage but not for poly(A) addition.


The eukaryotic translation initiation factor 4F complex is composed of eIF4E, eIF4A and eIF4G; it is involved in the recognition of the mRNA cap, ATP-dependent unwinding of the 5'-terminal secondary structure and recruitment of the mRNA to the ribosome.


positive regulation of formation of translation preinitiation complex

Any process that activates or increases the frequency, rate or extent of formation of translation preinitiation complex.


eukaryotic translation initiation factor 4F complex assembly

The aggregation, arrangement and bonding together of a set of components to form the eukaryotic translation initiation factor 4F complex.


mitochondrial ribosomal large subunit rRNA binding

Binding to a mitochondrial large ribosomal subunit RNA (LSU rRNA).


mitochondrial large ribosomal subunit assembly

The aggregation, arrangement and bonding together of a set of components to form a mitochondrial large ribosomal subunit.


MUB1-RAD6-UBR2 ubiquitin ligase complex

A ubiquitin ligase complex consisting of MUB1, RAD6 and UBR2 components. It ubiquitinates, and targets for destruction, the RPN4 transcription factor, which upregulates the proteasome genes. The binding of MUB1 may position the RPN4 ubiquitylation site proximal to the Ubiquitin-RAD6 thioester and allow the transfer of Ubiquitin from RAD6 to RPN4. One of its components, MUB1, is a short-lived protein ubiquitinated by the UBR2-RAD6 ubiquitin conjugating enzyme.


The chemical reactions and pathways involving phosphatidylethanolamine, any of a class of glycerophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of ethanolamine. It is a major structural phospholipid in mammalian systems. It tends to be more abundant than phosphatidylcholine in the internal membranes of the cell and is an abundant component of prokaryotic membranes.


ethanolamine transmembrane transporter activity

Enables the transfer of ethanolamine from one side of a membrane to the other. Ethanolamine (2-aminoethanol, monoethanolamine) is an amino alcohol that occurs widely in living organisms as a constituent of certain types of phospholipids, such as phosphatidylethanolamine.


(R)-carnitine transmembrane transporter activity

Enables the transfer of (R)-carnitine from one side of a membrane to the other.


glycine betaine transport

The directed movement of glycine betaine, N-trimethylglycine, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


(R)-carnitine transport

The directed movement of a (R)-carnitine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


ethanolamine transport

The directed movement of ethanolamine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Ethanolamine (2-aminoethanol, monoethanolamine) is an amino alcohol that occurs widely in living organisms as a constituent of certain types of phospholipids, such as phosphatidylethanolamine.


Catalysis of the reaction: beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + GDP-alpha-D-mannose = alpha-D-Man-(1->3)-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + GDP + H+. This reaction is the transfer of an alpha-D-mannosyl residue from GDP-mannose into lipid-linked oligosaccharide, forming an alpha-(1->3)-D-mannosyl-D-mannose linkage.


Catalysis of the transfer of an alpha-D-mannosyl residue from GDP-mannose into lipid-linked oligosaccharide, forming an alpha-(1->6)-D-mannosyl-D-mannose linkage.


activation of mitotic cell cycle spindle assembly checkpoint

Any process that starts the inactive process of a mitotic cell cycle spindle assembly checkpoint.


mannosyl-inositol phosphorylceramide metabolic process

The chemical reactions and pathways involving mannosyl-inositol phosphorylceramide, any lipid with a phosphodiester bridge between an inositol residue and the ceramide group which contains a phosphoryl (-P(O)=) groups and a mannose derivative.


Golgi vesicle fusion to target membrane

The joining of the lipid bilayer membrane around a Golgi transport vesicle to the target lipid bilayer membrane.


positive regulation of DNA-templated transcription initiation

Any process that activates or increases the frequency, rate or extent of DNA-templated transcription initiation.


ubiquinone-6 biosynthetic process

The chemical reactions and pathways resulting in the formation of ubiquinone-6.


mRNA cap methyltransferase complex

A protein complex that consists of an RNA 5' triphosphatase and a guanyl transferase (Cet1p and Ceg1p in S. cerevisiae; Pct1 and Ceg1 in S. pombe) and is involved in mRNA capping.


Dsl1/NZR complex

A multisubunit tethering complex, i.e. a protein complex involved in mediating the initial interaction between vesicles and the membranes with which they fuse, that is involved in trafficking from the Golgi apparatus to the ER. In Saccharomyces cerevisiae the Dsl1p complex contains Dsl1p, Tip20p, and Sec39p.


riboflavin reductase (NADPH) activity

Catalysis of the reaction: reduced riboflavin + NADP+ = riboflavin + NADPH + 2 H+.


aromatic amino acid family biosynthetic process

The chemical reactions and pathways resulting in the formation of aromatic amino acid family, amino acids with aromatic ring (phenylalanine, tyrosine, tryptophan).


chorismate synthase activity

Catalysis of the reaction: 5-O-(1-carboxyvinyl)-3-phosphoshikimate = chorismate + phosphate.


P-type manganese transporter activity

Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Mn2+(in) = ADP + H+ + Mn2+(out) + phosphate.


L-threonylcarbamoyladenylate synthase

Catalysis of the reaction: L-threonine + ATP + bicarbonate = L-threonylcarbamoyladenylate + diphosphate + H2O.


meiotic spindle pole body

The microtubule organizing center that forms as part of the meiotic cell cycle; functionally homologous to the animal cell centrosome.


positive regulation of mRNA binding

Any process that activates or increases the frequency, rate or extent of mRNA binding.


negative regulation of phosphatidylinositol biosynthetic process

Any process that decreases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of phosphatidylinositol.


vitamin transmembrane transporter activity

Enables the transfer of a vitamin from one side of a membrane to the other.


vitamin transport

The directed movement of vitamins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A vitamin is one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body.


D-serine metabolic process

The chemical reactions and pathways involving D-serine, the D-enantiomer of serine, i.e. (2R)-2-amino-3-hydroxypropanoic acid.


FACT complex

A histone chaperone complex that facilitates nucleosome disassembly and reassembly upon DNA or RNA polymerase passage.


regulation of sister chromatid cohesion

Any process that modulates the frequency, rate or extent of sister chromatid cohesion.


RNA decapping complex

A protein complex consisting of a Dcp1 regulatory subunit and a Dcp2 catalytic subunit that has mRNA cap binding activity and is involved in decapping of nuclear-transcribed mRNA.


pyrimidine nucleobase metabolic process

The chemical reactions and pathways involving pyrimidine nucleobases, 1,3-diazine, organic nitrogenous bases.


GDP-mannose transmembrane transporter activity

Enables the transfer of a GDP-mannose from one side of a membrane to the other. GDP-mannose is a substance composed of mannose in glycosidic linkage with guanosine diphosphate.


GDP-mannose transmembrane transport

The process in which GDP-mannose is transported across a membrane.


NLS-dependent protein nuclear import complex

A dimer consisting of an alpha and a beta-subunit that imports proteins with an NLS into the nucleus through a nuclear pore.


tRNA-specific adenosine-37 deaminase activity

Catalysis of the reaction: adenosine-37 + H2O = inosine-37 + NH3, in a tRNA-Ala molecule.


nitrogen catabolite regulation of transcription from RNA polymerase II promoter

A transcription regulation process in which the presence of one nitrogen source leads to the modulation of the frequency, rate, or extent of transcription, from an RNA polymerase II promoter, of specific genes involved in the metabolism of other nitrogen sources.


regulation of transcription by glucose

Any process involving glucose that modulates the frequency, rate or extent or transcription.


C-acetyltransferase activity

Catalysis of the transfer of an acetyl group to a carbon atom on the acceptor molecule.


tRNA guanylyltransferase activity

Catalysis of the posttranscriptional addition of a guanyl residue to the 5' end of a tRNA molecule; observed for His tRNAs.


TIM23 mitochondrial import inner membrane translocase complex

The protein transport machinery of the mitochondrial inner membrane that typically transports proteins that possess a matrix-targeting N-terminal presequence. The TIM23 complex contains three essential Tim proteins: Tim17 and Tim23 are thought to build a preprotein translocation channel while Tim44 interacts transiently with the matrix heat-shock protein Hsp70 to form an ATP-driven import motor.


TFIIIC-class transcription factor complex binding

Binding to a general RNA polymerase III transcription factor belonging to the TFIIC complex, one of the factors involved in formation of the preinitiation complex (PIC) by RNA polymerase III.


biotin transmembrane transporter activity

Enables the transfer of biotin from one side of a membrane to the other. Biotin is cis-tetrahydro-2-oxothieno(3,4-d)imidazoline-4-valeric acid; the (+) enantiomer is very widely distributed in cells and serves as a carrier in a number of enzymatic beta-carboxylation reactions.


biotin transport

The directed movement of biotin into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Biotin is cis-tetrahydro-2-oxothieno(3,4-d)imidazoline-4-valeric acid; the (+) enantiomer is very widely distributed in cells and serves as a carrier in a number of enzymatic beta-carboxylation reactions.


positive regulation of glycerol transport

Any process that increases the rate, frequency, or extent of the directed movement of glycerol into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


mitochondrial thiamine pyrophosphate transmembrane transport

The process in which thiamine pyrophosphate is transported across a mitochondrial membrane, into or out of the mitochondrion.


tRNA import into mitochondrion

The process in which a tRNA is transported from the cytosol into the mitochondrial matrix.


thiazole biosynthetic process

The chemical reactions and pathways resulting in the formation of a thiazole, a five-membered heterocyclic ring structure containing a sulfur in the 1-position and a nitrogen in the 3-position.


spermine transmembrane transporter activity

Enables the transfer of spermine from one side of a membrane to the other. Spermine is a polybasic amine found in human sperm, in ribosomes and in some viruses, which is involved in nucleic acid packaging. Synthesis is regulated by ornithine decarboxylase which plays a key role in control of DNA replication.


rRNA metabolic process

The chemical reactions and pathways involving rRNA, ribosomal RNA, a structural constituent of ribosomes.


cysteine biosynthetic process from serine

The chemical reactions and pathways resulting in the formation of cysteine from other compounds, including serine.


hydrogen sulfide biosynthetic process

The chemical reactions and pathways resulting in the formation of hydrogen sulfide, H2S.


alcohol O-acetyltransferase activity

Catalysis of the reaction: acetyl-CoA + an alcohol = CoA + an acetyl ester.


acetate ester metabolic process involved in fermentation

Any acetate ester metabolic process that is involved in fermentation.


high-affinity L-histidine transmembrane transporter activity

Enables the transfer of L-histidine from one side of a membrane to the other. L-histidine is 2-amino-3-(1H-imidazol-4-yl)propanoic acid. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations.


The directed movement of nucleobases, nucleosides, nucleotides and nucleic acids, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


CDP-choline pathway

The phosphatidylcholine biosynthetic process that begins with the phosphorylation of choline and ends with the combination of CDP-choline with diacylglycerol to form phosphatidylcholine.


meiotic DNA integrity checkpoint signaling

A signal transduction process that controls cell cycle progression in response to changes in DNA structure by monitoring the integrity of the DNA during meiosis. The DNA integrity checkpoint begins with detection of DNA damage, defects in DNA structure or DNA replication, and ends with signal transduction.


azole transmembrane transporter activity

Enables the directed movement of azoles, heterocyclic compound found in many biologically important substances, from one side of a membrane to the other.


azole transmembrane transport

The directed movement of azoles, heterocyclic compounds found in many biologically important substances, across a lipid bilayer, across a membrane.


dolichyl pyrophosphate Glc2Man9GlcNAc2 alpha-1,2-glucosyltransferase activity

Catalysis of the addition of the third glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation; the transfer of glucose from dolichyl phosphate glucose (Dol-P-Glc) on to the lipid-linked oligosaccharide Glc(2)Man(9)GlcNAc(2)-PP-Dol.


regulation of fungal-type cell wall biogenesis

Any process that modulates the process in which a cell wall is synthesized, aggregates, and bonds together. The fungal-type cell wall contains beta-glucan and may contain chitin.


nitric oxide reductase activity

Catalysis of the reaction: H2O + 2 ferricytochrome c + nitrous oxide = 2 H+ + 2 ferrocytochrome c + 2 nitric oxide.


cyclic nucleotide metabolic process

The chemical reactions and pathways involving a cyclic nucleotide, a nucleotide in which the phosphate group is in diester linkage to two positions on the sugar residue.


pyridoxal phosphate transport

The directed movement of pyridoxal phosphate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore; pyridoxal phosphate is pyridoxal phosphorylated at the hydroxymethyl group of C-5, and is the active form of vitamin B6.


quinolinic acid transmembrane transport

The process in which quinolinic acid is transported across a membrane.


Catalysis of the reaction: 2-octaprenyl-6-methoxyphenol + O2 + 4 H+ = 2-octaprenyl-6-methoxy-1,4-benzoquinol + H2O.


generation of mature 3'-end of 5S rRNA generated by RNA polymerase III

The removal of extra uridine residues from the 3' end of a 5S pre-rRNA generated by transcription by RNA polymerase III to generate the mature 3'-end.


xenobiotic transport

The directed movement of a xenobiotic into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A xenobiotic is a compound foreign to the organim exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical.


steryl deacetylase activity

Catalysis of the hydrolysis of an acetyl group or groups from an acetylated sterol.


distributive segregation

The cell cycle process in which genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets during a normally chiasmate meiosis under the condition that chiasma have not occurred between a particular pair of homologs. Distributive segregation is a backup mechanism to ensure the segregation of homologs that have failed to cross over - either as a consequence of mutation or not, as, for example, the 4th chromosome of Drosophila melanogaster (which never exchanges, presumably due to its small size) - but nevertheless segregate normally.


polyphosphate kinase activity

Catalysis of the reaction: ATP + phosphate(n) = ADP + phosphate(n+1).


An protein-containing complex which catalyzes of the transfer of a geranyl-geranyl group from geranylgeranyl pyrophosphate to a Rab protein. In mammals it is composed of an alpha and a beta subunit, and associates with an accessory protein Rep (Rab escort protein).


lipoate-protein ligase activity

Catalysis of the lipoylation of a protein in two steps: ATP + (R)-lipoate + a [lipoyl-carrier protein]-L-lysine = a [lipoyl-carrier protein]-N6-(lipoyl)lysine + AMP + diphosphate (overall reaction): (1) ATP + (R)-lipoate = lipoyl-AMP + diphosphate; (2) lipoyl-AMP + a [lipoyl-carrier protein]-L-lysine = a [lipoyl-carrier protein]-N6-(lipoyl)lysine + AMP.


lysine transport

The directed movement of lysine, 2,6-diaminohexanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


low-affinity zinc ion transmembrane transporter activity

Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Zn2+ = Zn2+, probably powered by proton motive force. In low-affinity transport the transporter is able to bind the solute only if it is present at very high concentrations.


Catalysis of the reaction: glucosaminyl-phosphatidylinositol + fatty acyl-CoA = glucosaminyl-acyl-phasphotidylinositol + CoA.


deaminated glutathione amidase activity

Catalysis of the reaction: N-(4-oxoglutarate)-L-cysteinylglycine + H2O = 2-oxoglutarate + L-cysteinylglycine.


amide catabolic process

The chemical reactions and pathways resulting in the breakdown of an amide, any derivative of an oxoacid in which an acidic hydroxy group has been replaced by an amino or substituted amino group.


negative regulation of pyrimidine nucleobase metabolic process

Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving pyrimidine nucleobases.


tRNA (m1A) methyltransferase complex

A protein complex involved in the catalysis of the formation of the modified nucleotide 1-methyladenosine (m1A) in tRNA. In yeast, it is a heterotetramer of two subunits, Gcd10p and Gcd14p, while in bacteria and archaea it is a homotetramer.


endosome transport via multivesicular body sorting pathway

The directed movement of substances from endosomes to lysosomes or vacuoles by a pathway in which molecules are sorted into multivesicular bodies, which then fuse with the target compartment.


(1->6)-beta-D-glucan metabolic process

The chemical reactions and pathways involving (1->6)-beta-D-glucans, compounds composed of glucose residues linked by (1->6)-beta-D-glucosidic bonds.


fatty acid elongation, unsaturated fatty acid

Elongation of a fatty acid chain into which one or more C-C double bonds have been introduced.


DNA exonuclease activity

Catalysis of the sequential cleavage of mononucleotides from a free 5' or 3' terminus of a DNA molecule.


mitochondrial mRNA catabolic process

The chemical reactions and pathways resulting in the breakdown of mRNA transcribed from the mitochondrial genome and occurring in the mitochondrion.


dihydroxy-acid dehydratase activity

Catalysis of the reaction: 2,3-dihydroxy-3-methylbutanoate = 3-methyl-2-oxobutanoate + H2O.


positive regulation of rDNA heterochromatin formation

Any process that activates or increases the frequency, rate or extent of rDNA heterochromatin formation.


hexose catabolic process

The chemical reactions and pathways resulting in the breakdown of hexose, any monosaccharide with a chain of six carbon atoms in the molecule.


Vps55/Vps68 complex

A membrane-associated protein complex that is required for a late stage of endosomal transport. In budding yeast, this complex consists of Vps55p and Vps68p proteins.


FAD metabolic process

The chemical reactions and pathways involving FAD, the oxidized form of flavin adenine dinucleotide.


post-spliceosomal complex

A spliceosomal complex that is formed following the second splicing event and contains the spliced product, the excised intron, and three snRNPs, including U5.


dUDP biosynthetic process

The chemical reactions and pathways resulting in the formation of dUDP, deoxyuridine diphosphate (2'-deoxy-5'-uridylyl phosphate).


protein-N-terminal glutamine amidohydrolase activity

Catalysis of the reaction: N-terminal L-glutaminyl-[protein] + H2O = N-terminal L-glutamyl-[protein] + NH3. This reaction is the deamidation of an N-terminal glutamine residue of a protein.


N-terminal protein amino acid modification

The alteration of the N-terminal amino acid residue in a protein.


phosphoadenylyl-sulfate reductase (thioredoxin) activity

Catalysis of the reaction: adenosine 3',5'-diphosphate + H+ + sulfite + thioredoxin disulfide = 3'-phospho-5'-adenylyl sulfate + thioredoxin. Thioredoxin disulfide is the oxidized form of thioredoxin; 3'-phosphoadenosine 5'-phosphosulfate is also known as PAPS.


Yae1-Lto1 complex

A cytosolic complex that functions as an substrate-specific adaptor, linking the cytosolic iron-sulfur protein assembly (CIA) targeting complex to apo-Rli1p, an ABC protein involved in ribosome recycling, facilitating Fe-S cluster insertion and the maturation of the Rli1p.


dGTP diphosphatase activity

Catalysis of the reaction: dGTP + H2O = dGMP + H+ + diphosphate.


UTP diphosphatase activity

Catalysis of the reaction: UTP + H2O = UMP + H+ + diphosphate.


dTTP diphosphatase activity

Catalysis of the reaction: dTTP + H2O = dTMP + H+ + diphosphate.


dATP diphosphatase activity

Catalysis of the reaction: dATP + H2O = dAMP + H+ + diphosphate.


GTP diphosphatase activity

Catalysis of the reaction: GTP + H2O = GMP + H+ + diphosphate.


Catalysis of the reaction: S-adenosyl-L-methionine + phosphatidyl-N-dimethylethanolamine = S-adenosyl-L-homocysteine + phosphatidylcholine.


substituted mannan metabolic process

The chemical reactions and pathways involving a mannan backbone composed of D-mannose unites, substituted with D-glucose and/or D-galactose units.


Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: succinate(out) + fumarate(in) = succinate(in) + fumarate(out).


fumarate transport

The directed movement of fumarate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


negative regulation of autophagy of mitochondrion

Any process that stops, prevents or reduces the frequency, rate or extent of mitochondrion degradation by autophagy.


ESCRT II complex

An endosomal sorting complex required for transport and functions downstream of ESCRT I complex. It consists of the class E vacuolar protein sorting (Vps) proteins and is required for the membrane recruitment of ESCRT III complex and binds to ubiquitinated cargoes.


regulation of G0 to G1 transition

A cell cycle process that modulates the rate or extent of the transition from the G0 quiescent state to the G1 phase.


carbamoyl-phosphate synthase complex

A protein complex that catalyzes the formation of carbamoyl phosphate; comprises a small subunit that binds and cleaves glutamine, and a large subunit that accepts the ammonia group cleaved from glutamine, binds all of the remaining substrates and effectors, and carries out all of the other catalytic events.


negative regulation of post-translational protein targeting to membrane, translocation

Any process that stops, prevents or reduces the frequency, rate or extent of posttranslational protein translocation through the ER membrane.


multivesicular body sorting pathway

A vesicle-mediated transport process in which transmembrane proteins are ubiquitylated to facilitate their entry into luminal vesicles of multivesicular bodies (MVBs); upon subsequent fusion of MVBs with lysosomes or vacuoles, the cargo proteins are degraded.


protein deglycosylation involved in glycoprotein catabolic process

The removal of sugar residues from a glycosylated protein that contributes to the breakdown of a glycoprotein.


cystathionine gamma-synthase activity

Catalysis of the reaction: O-succinyl-L-homoserine + L-cysteine = cystathionine + succinate.


XMP salvage

Any process which produces xanthosine monophosphate from derivatives of it, without de novo synthesis.


Catalysis of the reaction: 5-phospho-alpha-D-ribose 1-diphosphate + xanthine = (9-D-ribosylxanthine)-5'-phosphate + diphosphate.


sulfur amino acid biosynthetic process

The chemical reactions and pathways resulting in the formation of amino acids containing sulfur, comprising cysteine, methionine and selenocysteine.


dolichyl-phosphate-mannose-protein mannosyltransferase Pmt4p homodimer complex

A protein dimer complex that possesses dolichyl-phosphate-mannose-protein mannosyltransferase activity and, in S. cerevisiae, is composed of Pmt4p.


polygalacturonase activity

Catalysis of the random hydrolysis of (1->4)-alpha-D-galactosiduronic linkages in pectate and other galacturonans.


pectin catabolic process

The chemical reactions and pathways resulting in the breakdown of pectin, a polymer containing a backbone of alpha-1,4-linked D-galacturonic acid residues.


allantoate transport

The directed movement of allantoate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


cadmium ion transmembrane transporter activity

Enables the transfer of cadmium (Cd) ions from one side of a membrane to the other.


Catalysis of the reaction: NTP + 5'-dephosphopolynucleotide = NDP + 5'-phosphopolynucleotide. The polynucleotide may be DNA or RNA.


sulfur compound catabolic process

The chemical reactions and pathways resulting in the breakdown of compounds that contain sulfur, such as the amino acids methionine and cysteine or the tripeptide glutathione.


sulfonate dioxygenase activity

Catalysis of the reaction: sulfonate + 2-oxoglutarate + O2 = sulfite + aminoacetaldehyde + succinate + CO2.


Noc2p-Noc3p complex

A heterodimer associated with 66S preribosomes; predominantly nucleoplasmic, but also locates to the nucleolus; involved in ribosomal large subunit biogenesis.


positive regulation of pyrimidine nucleotide biosynthetic process

Any process that activates or increases the frequency, rate or extent of pyrimidine nucleotide biosynthetic process.


ESCRT III complex assembly

The aggregation, arrangement and bonding together of a set of components to form an ESCRT III complex.


MutLbeta complex

A heterodimer involved in the recognition of base-base and small insertion/deletion mismatches. In human the complex consists of two subunits, MLH1 and PMS1.


bubble DNA binding

Binding to DNA segment that contains a bubble. A bubble occurs when DNA contains a region of unpaired, single-stranded DNA flanked on both sides by regions of paired, double-stranded DNA.


regulatory ncRNA 3'-end processing

Any process involved in forming the mature 3' end of a regulatory non-coding RNA molecule.


cis assembly of pre-catalytic spliceosome

Assembly of a spliceosomal complex containing the intact pre-mRNA and all of the spliceosomal snRNPs. This occurs when the tri-snRNP associates with the pre-mRNA and associated snRNPs in an ATP-dependent manner.


ubiquitin-like protein binding

Binding to a small conjugating protein such as ubiquitin or a ubiquitin-like protein.


poly(U)-specific exoribonuclease activity, producing 3' uridine cyclic phosphate ends

Catalysis of 3' exonucleolytic cleavage of poly(U), to form poly(U)-N containing a 3' uridine cyclic phosphate (U>P).


U6 snRNA 3'-end processing

Any process involved in forming the mature 3' end of a U6 snRNA molecule.


regulation of meiotic DNA double-strand break formation involved in reciprocal meiotic recombination

Any process that modulates the frequency, rate or extent of meiotic DNA double-strand break formation involved in reciprocal meiotic recombination.


spermine biosynthetic process

The chemical reactions and pathways resulting in the formation of spermine, a polybasic amine found in human sperm, in ribosomes and in some viruses and involved in nucleic acid packaging.


triplex DNA binding

Binding to a DNA triple helix. The formation of triple helical DNA has been evoked in several cellular processes including transcription, replication, and recombination.


pseudouridylate synthase activity

Catalysis of the reaction: D-ribose 5-phosphate + uracil = H2O + pseudouridine 5'-phosphate.


pseudouridine synthesis

The intramolecular conversion of uridine to pseudouridine within an RNA molecule.


box H/ACA RNA 3'-end processing

Any process involved in forming the mature 3' end of a box H/ACA RNA molecule.


isocitrate metabolic process

The chemical reactions and pathways involving isocitrate, the anion of isocitric acid, 1-hydroxy-1,2,3-propanetricarboxylic acid. Isocitrate is an important intermediate in the TCA cycle and the glycoxylate cycle.


Catalysis of the reaction: UDP-glucose + a sterol = UDP + an O-glucosylsterol.


oligopeptide export from mitochondrion

The process in which an oligopeptide is transported out of the mitochondrial matrix. Oligopeptides are molecules that contain a small number (2 to 20) of amino-acid residues connected by peptide linkages.


Hrd1p ubiquitin ligase ERAD-M complex

A multiprotein complex that recognizes and ubiquitinates proteins with misfolded membrane domains during ER-associated protein degradation (ERAD). In S. cerevisiae, this complex contains the ubiquitin ligase Hrd1p.


negative regulation of protein autoubiquitination

Any process that stops, prevents or reduces the frequency, rate or extent of protein autoubiquitination.


inosine nucleosidase activity

Catalysis of the reaction: inosine + H2O = D-ribose + hypoxanthine.


transcription coactivator binding

Binding to a transcription coactivator, a protein involved in positive regulation of transcription via protein-protein interactions with transcription factors and other proteins that positively regulate transcription. Transcription coactivators do not bind DNA directly, but rather mediate protein-protein interactions between activating transcription factors and the basal transcription machinery.


telomerase catalytic core complex

The minimal catalytic core of telomerase is a ribonucleoprotein complex composed of a catalytic reverse transcriptase subunit and an RNA subunit that provides the template for telomeric DNA addition.


template for synthesis of G-rich strand of telomere DNA activity

Provision of the template used by reverse transcriptase to synthesize the G-rich strand of telomeric DNA.


ligase activity

Catalysis of the joining of two molecules, or two groups within a single molecule, using the energy from the hydrolysis of ATP, a similar triphosphate, or a pH gradient.


regulation of plasma membrane sterol distribution

Any process that modulates the proportions or spatial arrangement of sterols in the plasma membrane.


deoxycytidine catabolic process

The chemical reactions and pathways resulting in the breakdown of deoxycytidine, 2-deoxyribosylcytosine, one of the four major nucleosides of DNA.


endoplasmic reticulum palmitoyltransferase complex

A complex of the endoplasmic reticulum that catalyzes S-palmitoylation, the addition of palmitate (C16:0) or other long-chain fatty acids to proteins at a cysteine residue.


cysteine synthase activity

Catalysis of the reaction: O3-acetyl-L-serine + hydrogen sulfide = L-cysteine + acetate.


glucan metabolic process

The chemical reactions and pathways involving glucans, polysaccharides consisting only of glucose residues.


chitin deacetylase activity

Catalysis of the reaction: chitin + H2O = chitosan + acetate.


cell wall chitin catabolic process

The chemical reactions and pathways resulting in the breakdown of cell wall chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues, found in the walls of cells.


telomerase RNA reverse transcriptase activity

Catalysis of the extension of the 3' end of a DNA strand by one deoxynucleotide at a time. Cannot initiate a chain de novo; uses the RNA subunit of the telomerase enzyme complex as its template.


ketol-acid reductoisomerase activity

Catalysis of the reaction: (R)-2,3-dihydroxy-3-methylbutanoate + NADP+ = (S)-2-hydroxy-2-methyl-3-oxobutanoate + NADPH + H+.


periplasmic space

The region between the inner (cytoplasmic) and outer membrane (Gram-negative Bacteria) or cytoplasmic membrane and cell wall (Fungi and Gram-positive Bacteria).


negative regulation of phosphatidylglycerol biosynthetic process

Any process that stops, prevents or reduces the frequency, rate or extent of phosphatidylglycerol biosynthetic process.


vesicle fusion with vacuole

The joining of the lipid bilayer membrane around a vesicle with the lipid bilayer membrane around the vacuole.


inositol hexakisphosphate 4-kinase activity

Catalysis of the reaction: ATP + 1D-myo-inositol hexakisphosphate = ADP + 4-diphospho-1D-myo-inositol (1,2,3,5,6)pentakisphosphate.


inositol hexakisphosphate 3-kinase activity

Catalysis of the reaction: ATP + 1D-myo-inositol hexakisphosphate = ADP + 3-diphospho-1D-myo-inositol (1,2,4,5,6)pentakisphosphate.


inositol hexakisphosphate 1-kinase activity

Catalysis of the reaction: ATP + 1D-myo-inositol hexakisphosphate = ADP + 1-diphospho-1D-myo-inositol (2,3,4,5,6)pentakisphosphate.


Catalysis of the reaction: 1-diphospho-1D-myo-inositol 2,3,4,5,6-pentakisphosphate + H2O = 1D-myo-inositol 1,2,3,4,5,6-hexakisphosphate + phosphate + 2 H+.


pyrimidine nucleotide biosynthetic process

The chemical reactions and pathways resulting in the formation of a pyrimidine nucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar.


positive regulation of autophagosome size

Any process that increases autophagosome size.


positive regulation of leucine biosynthetic process

Any process that activates or increases the frequency, rate or extent of leucine biosynthetic process.


tRNA (uracil) methyltransferase activity

Catalysis of the transfer of a methyl group from a donor to a uracil residue in a tRNA molecule.


adenine salvage

Any process that generates adenine, 6-aminopurine, from derivatives of it without de novo synthesis.


The directed movement of nucleotide-sugars into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Nucleotide-sugars are any nucleotide in which the distal phosphoric residue of a nucleoside 5'-diphosphate is in glycosidic linkage with a monosaccharide or monosaccharide derivative.


L-lactate dehydrogenase (cytochrome) activity

Catalysis of the reaction: (S)-lactate + 2 [Fe(III)cytochrome c] = 2 [Fe(II)cytochrome c] + 2 H+ + pyruvate.


phosphatidylcholine catabolic process

The chemical reactions and pathways resulting in the breakdown of phosphatidylcholines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of choline.


spore membrane bending pathway

The process in which a bending force is generated in the prospore membrane to form the characteristic curved shape of the prospore.


organic acid transport

The directed movement of organic acids, any acidic compound containing carbon in covalent linkage, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


Catalysis of the reaction: D-arabinono-1,4-lactone + O2 = dehydro-D-arabinono-1,4-lactone + H2O2 + H+.


The chemical reactions and pathways resulting in the formation of dehydro-D-arabinono-1,4-lactone, the gamma-lactone (5R)-3,4-dihydroxy-5-(hydroxymethyl)furan-2(5H)-one.


mitochondrial ribonuclease P complex

A ribonuclease P complex located in the mitochondrion of a eukaryotic cell, where it catalyzes the 5' endonucleolytic cleavage of precursor tRNAs to yield mature tRNAs. The subunit composition of mitochondrial ribonuclease P complexes varies between species. The complex contains a single RNA molecule and a single protein molecule in yeast (PMID:12045094), but comprises three proteins and lacks an RNA component in humans.


nucleotide-excision repair factor 1 complex

One of several protein complexes involved in nucleotide-excision repair; possesses DNA damage recognition and endodeoxynuclease activities. In S. cerevisiae, it is composed of Rad1p, Rad10p, and Rad14p; in human the subunits are ERCC4/XPF, ERCC1 and XPA, respectively.


SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition

The process in which SRP binds to the signal peptide in a nascent protein, causing protein elongation to pause, during cotranslational membrane targeting.


pyrimidine ribonucleoside biosynthetic process

The chemical reactions and pathways resulting in the formation of any ribonucleoside, a nucleoside in which a pyrimidine base is linked to a ribose (beta-D-ribofuranose) molecule.


borate efflux transmembrane transporter activity

Enables the transfer of borate from the inside of the cell to the outside of the cell across a membrane.


borate transport

The directed movement of borate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Borate is the anion (BO3)3-; boron is a group 13 element, with properties which are borderline between metals and non-metals.


polyadenylation-dependent RNA catabolic process

The chemical reactions and pathways resulting in the breakdown of an RNA molecule, initiated by the enzymatic addition of a sequence of adenylyl residues (polyadenylation) at the 3'-end of the target RNA.


negative regulation of mitochondrial translation

Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA in a mitochondrion.


acireductone dioxygenase (Ni2+-requiring) activity

Catalysis of the reaction: 1,2-dihydroxy-5-(methylthio)pent-1-en-3-one + O2 = 3-(methylthio)propanoate + CO + formate.


dolichyl monophosphate biosynthetic process

The chemical reactions and pathways resulting in the formation of dolichyl diphosphate, a phosphorylated dolichol derivative.


ornithine carbamoyltransferase inhibitor activity

Binds to and stops, prevents, or reduces the activity of ornithine carbamoyltransferase.


arginine catabolic process to ornithine

The chemical reactions and pathways resulting in the breakdown of arginine into other compounds, including ornithine.


regulation of ornithine metabolic process

Any process that modulates the rate, frequency, or extent of the chemical reactions and pathways involving ornithine, an amino acid only rarely found in proteins, but which is important in living organisms as an intermediate in the reactions of the urea cycle and in arginine biosynthesis.


reductive iron assimilation

A process in which iron is solubilized by reduction from Fe3+ to Fe2+ via a cell surface reductase and subsequent transport of the iron across the membrane by iron uptake proteins.


mitochondrial chromosome packaging

A process in which mitochondrial chromosomal DNA and associated proteins organize into a compact, orderly structure.


Enables the directed movement of phosphatidylcholine into, out of or within a cell, or between cells. Phosphatidylcholine refers to a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of choline.


Catalysis of the reaction: alpha-D-glucose 6-phosphate = beta-D-glucose 6-phosphate.


dihydrofolate synthase activity

Catalysis of the reaction: ATP + dihydropterate + L-glutamate = ADP + phosphate + dihydrofolate.


Asi complex

A nuclear ubiquitin ligase multiprotein complex located in the inner nuclear membrane (INM) that recognizes and ubiquitinates misfolded INM proteins and also some proteins involved in sterol biosynthesis, during ER-associated protein degradation (ERAD). In S. cerevisiae, this complex contains the ubiquitin ligases Asi1p and Asi3p.


alcohol dehydrogenase [NAD(P)+] activity

Catalysis of the reaction: an alcohol + NAD(P)+ = an aldehyde + NAD(P)H + H+.


response to spindle checkpoint signaling

A process that occurs in response to signals generated as a result of spindle checkpoint signaling.


magnesium ion export from mitochondrion

The directed movement of magnesium ions out of mitochondrial matrix into the cytosol by means of some agent such as a transporter or pore.


MutLgamma complex

A heterodimer involved in the recognition of base-base and small insertion/deletion mismatches. In S. cerevisiae the complex consists of two subunits, Mlh1 and Mlh3.


meiotic heteroduplex formation

During meiosis, the formation of a stable duplex DNA that contains one strand from each of the two recombining DNA molecules.


FAD diphosphatase activity

Catalysis of the reaction: FAD + H2O = AMP + FMN.


flavin-containing compound metabolic process

The chemical reactions and pathways involving a flavin, any derivative of the dimethylisoalloxazine (7,8-dimethylbenzo[g]pteridine-2,4(3H,10H)-dione) skeleton, with a substituent on the 10 position.


box C/D RNA binding

Binding to a box C/D small nucleolar RNA.


alpha-ketoglutarate transport

The directed movement of alpha-ketoglutarate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


box H/ACA RNA processing

Any process involved in the conversion of a primary box H/ACA type small RNA transcript into a mature box H/ACA RNA.


box C/D RNA processing

Any process involved in the conversion of a primary box C/D type small RNA transcript into a mature box C/D RNA.


RNA secondary structure unwinding

The process in which a secondary structure of RNA are broken or 'melted'.


borate transmembrane transport

The process in which borate is transported across a membrane. Borate is the anion (BO3)3-; boron is a group 13 element, with properties which are borderline between metals and non-metals.


charged-tRNA amino acid modification

The covalent alteration of an amino acid charged on a tRNA before it is incorporated into a protein, as in N-formylmethionine, selenocysteine or pyrrolysine.


A dicarboxylic acid monoanion that is the conjugate base of 4-amino-4-deoxychorismic acid.


An  aromatic amino-acid anion that is the conjugate base of 4-aminobenzoic acid.


mitochondrial degradosome

A mitochondrial protein complex with 3' to 5' exoribonuclease activity that participates in intron-independent turnover and processing of mitochondrial transcripts. In humans, the mitochondrial degradosome is a pentameric complex, and in yeast it exists as a heterodimer.


exoribonuclease II activity

Catalysis of the reaction: RNA + H2O = 5'-phosphomononucleotides. Cleaves RNA in the 3' to 5' direction.


snoRNA release from pre-rRNA

The release of snoRNA from pre-rRNA.


Catalysis of the transfer of acyl groups from an acyl-CoA to lysophosphatidylethanolamine.


hydroxymethylfurfural reductase (NADPH) activity

Catalysis of the reaction: 5-hydroxymethylfurfural + NADPH + H+ = 2,5-bis-hydroxymethylfuran + NADP+.


S-adenosyl-L-methionine transport

The directed movement of S-adenosylmethionine, S-(5'-adenosyl)-L-methionine, an important intermediate in one-carbon metabolism, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


exonucleolytic trimming to generate mature 5'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

Exonucleolytic digestion of a pre-rRNA molecule to generate the mature 5'-end of a 5.8S rRNA molecule derived from an originally tricistronic pre-rRNA transcript that contained the Small Subunit (SSU) rRNA, the 5.8S rRNA, and the Large Subunit (LSU) rRNA in that order from 5' to 3' along the primary transcript.


sorbitol-6-phosphatase activity

Catalysis of the reaction: D-glucitol 6-phosphate + H2O = D-glucitol + phosphate.


ribitol-5-phosphatase activity

Catalysis of the reaction: ribitol-5-phosphate + H20 = ribitol + phosphate.


alditol phosphate metabolic process

The chemical reactions and pathways involving alditol phosphates, any phosphorylated polyhydric alcohol derived from the acyclic form of a monosaccharide by reduction of its aldehyde or keto group to an alcoholic group.


mannosylation

The covalent attachment of a mannose residue to a substrate molecule.


cell wall chitin biosynthetic process

The chemical reactions and pathways resulting in the formation of cell wall chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues, found in the walls of cells.


cellular response to blue light

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a blue light stimulus. Blue light is electromagnetic radiation with a wavelength of between 440 and 500nm.


Catalysis of the reaction: an alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + 2 GDP-alpha-D-mannose = an alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + 2 GDP + 2 H+. This reaction is the transfer of an alpha-D-mannosyl residue from GDP-mannose into lipid-linked oligosaccharide, forming an alpha-(1->2)-D-mannosyl-D-mannose linkage.


translational readthrough

The continuation of translation beyond a stop codon by the use of a special tRNA that recognizes the UAG and UGA codons as modified amino acids, rather than as termination codons.


2-isopropylmalate synthase activity

Catalysis of the reaction: 3-methyl-2-oxobutanoate + acetyl-CoA + H2O = (2S)-2-isopropylmalate + CoA + H+.


messenger ribonucleoprotein complex assembly

The aggregation, arrangement and bonding together of proteins and messenger RNA (mRNA) molecules to form a messenger ribonucleoprotein (mRNP) complex.


nicotinamide riboside metabolic process

The chemical reactions and pathways involving nicotinamide riboside, the product of the formation of a glycosidic bond between ribose and nicotinamide.


rRNA cytidine N-acetyltransferase activity

Catalysis of the reaction: acetyl-CoA + cytidine = CoA + N4-acetylcytidine. The cytidine is within the polynucleotide chain of an rRNA.


positive regulation of filamentous growth of a population of unicellular organisms

Any process that activates or increases the frequency, rate or extent of filamentous growth of a population of unicellular organisms.


adenine deaminase activity

Catalysis of the reaction: adenine + H2O = hypoxanthine + NH3.


adenine catabolic process

The chemical reactions and pathways resulting in the breakdown of adenine, 6-aminopurine, one of the 5 main bases found in nucleic acids and a component of numerous important derivatives of its corresponding ribonucleoside, adenosine.


hypoxanthine salvage

Any process that generates hypoxanthine, 6-hydroxy purine, from derivatives of it without de novo synthesis.


cell wall assembly

The aggregation, arrangement and bonding together of a cell wall. A cell wall is a rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells.


2,4-dienoyl-CoA reductase (NADPH) activity

Catalysis of the reaction: trans-2,3-didehydroacyl-CoA + NADP+ = trans,trans-2,3,4,5-tetradehydroacyl-CoA + NADPH + H+.


deoxyribonucleoside triphosphate biosynthetic process

The chemical reactions and pathways resulting in the formation of a deoxyribonucleoside triphosphate, a compound consisting of a nucleobase linked to a deoxyribose sugar esterified with triphosphate on the sugar.


positive regulation of RNA import into nucleus

Any process that activates or increases the frequency, rate or extent of movement of RNA from the cytoplasm into the nucleus.


U1 snRNP binding

Binding to a U1 small nuclear ribonucleoprotein particle.


Catalysis of the reaction: alpha-D-man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-(alpha-D-Man-(1->6))-alpha-D-Man-(1->6))-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + dolichyl D-mannosyl phosphate = H+ + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->6))-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + dolichyl phosphate.


Catalysis of the reaction: alpha-D-man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-(alpha-D-Man-(1->3)-alpha-D-Man-(1->6))-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + dolichyl D-mannosyl phosphate = H+ + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Man-(1->6))-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + dolichyl phosphate.


homocysteine catabolic process

The chemical reactions and pathways resulting in the breakdown of homocysteine, the amino acid alpha-amino-gamma-mercaptobutanoic acid.


acetyltransferase activator activity

Binds to and increases the activity of an acetyltransferase, an enzyme which catalyzes the transfer of an acetyl group to an acceptor molecule.


negative regulation of sexual sporulation resulting in formation of a cellular spore

Any process that stops, prevents, or reduces the frequency, rate or extent of the formation of cellular spores derived from the products of meiosis.


ferredoxin hydrogenase activity

Catalysis of the reaction: 2 reduced ferredoxin + 2 H+ = 2 oxidized ferredoxin + H2.


transcription regulatory region RNA binding

Binding to a RNA region within the transcript that regulates the transcription of a gene, cistron, or operon.


CUT catabolic process

The chemical reactions and pathways resulting in the breakdown of cryptic unstable transcripts (CUTs).


snRNA 3'-end processing

Any process involved in forming the mature 3' end of an snRNA molecule.


Catalysis of the beta-elimination of the 5' deoxyribose-5-phosphate at an abasic site in DNA where a DNA-(apurinic or apyrimidinic site) lyase has already cleaved the C-O-P bond 3' to the apurinic or apyrimidinic site.


polyadenylation-dependent mRNA catabolic process

The chemical reactions and pathways resulting in the breakdown of a messenger RNA (mRNA) molecule, initiated by the enzymatic addition of a sequence of adenylyl residues (polyadenylation) at the 3' end the target mRNA.


nuclear mRNA surveillance of spliceosomal pre-mRNA splicing

The set of processes involved in identifying and degrading incorrectly spliced pre-mRNAs within the nucleus.


dihydroneopterin aldolase activity

Catalysis of the reaction: 2-amino-4-hydroxy-6-(D-erythro-1,2,3-trihydroxypropyl)-7,8-dihydropteridine = 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine + glycolaldehyde.


Catalysis of the reaction: 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine + ATP = (2-amino-4-hydroxy-7,8-dihydropteridin-6-yl)methyl diphosphate + AMP + 2 H+.


dihydropteroate synthase activity

Catalysis of the reaction: 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate + 4-aminobenzoate = diphosphate + dihydropteroate.


tetrahydrofolate biosynthetic process

The chemical reactions and pathways resulting in the formation of tetrahydrofolate, 5,6,7,8-tetrahydrofolic acid, a folate derivative bearing additional hydrogens on the pterin group.


plasma membrane fusion involved in cytogamy

The joining of two or more lipid bilayer membranes that surround cells, that contributes to cytogamy.


methylisocitrate lyase activity

Catalysis of the reaction: (2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate = pyruvate + succinate.


propionate catabolic process, 2-methylcitrate cycle

The chemical reactions and pathways resulting in the breakdown of propionate that occurs in the 2-methylcitrate cycle.


glyoxylate reductase (NAD+) activity

Catalysis of the reaction: glycolate + NAD+ = glyoxylate + NADH.


glyoxylate catabolic process

The chemical reactions and pathways resulting in the breakdown of glyoxylate, the anion of glyoxylic acid, HOC-COOH.


regulation of vacuole organization

Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a vacuole.