CLD1_HUMAN Claudin-1 (sprot)

A claudin-1 that is encoded in the genome of human.


CLD15_HUMAN Claudin-15 (sprot)

A claudin-15 that is encoded in the genome of human.


CLD6_HUMAN Claudin-6 (sprot)

A claudin-6 that is encoded in the genome of human.


CLD8_HUMAN Claudin-8 (sprot)

A claudin-8 that is encoded in the genome of human.


CLD12_HUMAN Claudin-12 (sprot)

A claudin-12 that is encoded in the genome of human.


CLD17_HUMAN Claudin-17 (sprot)

A claudin-17 that is encoded in the genome of human.


CLD18_HUMAN Claudin-18 (sprot)

A claudin-18 that is encoded in the genome of human.


CLD20_HUMAN Claudin-20 (sprot)

A claudin-20 that is encoded in the genome of human.


CLD2_HUMAN Claudin-2 (sprot)

A claudin-2 that is encoded in the genome of human.


CLD10_HUMAN Claudin-10 (sprot)

A claudin-10 that is encoded in the genome of human.


CLD19_HUMAN Claudin-19 (sprot)

A claudin-19 that is encoded in the genome of human.


CLD22_HUMAN Claudin-22 (sprot)

A claudin-22 that is encoded in the genome of human.


CLD23_HUMAN Claudin-23 (sprot)

A claudin-23 that is encoded in the genome of human.


CLD16_HUMAN Claudin-16 (sprot)

A claudin-16 that is encoded in the genome of human.


triplet codon-amino acid adaptor activity

biolink:MolecularActivity biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:NamedThing biolink:Occurrent biolink:OntologyClass biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

The codon binding activity of a tRNA that positions an activated amino acid, mediating its insertion at the correct point in the sequence of a nascent polypeptide chain during protein synthesis.


late recombination nodule

biolink:CellularComponent biolink:AnatomicalEntity biolink:OrganismalEntity biolink:BiologicalEntity biolink:NamedThing biolink:PhysicalEssence biolink:SubjectOfInvestigation biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

An electron dense structure that is associated with meiotic chromosomes in pachytene during meiosis I.


meiotic spindle midzone assembly

biolink:BiologicalProcess biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:NamedThing biolink:Occurrent biolink:OntologyClass biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

The formation of the spindle midzone, the area in the center of the spindle where the spindle microtubules from opposite poles overlap, as a part of the process of meiosis.


meiotic metaphase I homologous chromosome alignment

A cell cycle process whereby homlogous chromosomes are positioned in a specific order and orientation at the metaphase plate (spindle equator) by the spindle machinery and centromere/kinetochore arrangement during meiosis I chromosome segregation. This alignment ensures that each daughter cell will receive the correct number of chromosomes during cell division.


regulation of forebrain neuron differentiation

Any process that modulates the frequency, rate or extent of forebrain neuron differentiation.


negative regulation of T-helper 17 cell differentiation

Any process that stops, prevents or reduces the frequency, rate or extent of T-helper 17 cell differentiation.


MRF binding

Binding to Myogenic Regulatory Factor (MRF), a member of the basic Helix-Loop-Helix (bHLH) superfamily of transcription factors.


salivary gland development

The process whose specific outcome is the progression of the salivary gland over time, from its formation to the mature structure. Salivary glands include any of the saliva-secreting exocrine glands of the oral cavity.


glandular epithelial cell development

The process whose specific outcome is the progression of a glandular epithelial cell over time, from its formation to the mature structure. A glandular epithelial cell is a columnar/cuboidal epithelial cell is a cell found in a two dimensional sheet with a free surface exposed to the lumen of a gland.


cell migration involved in endocardial cushion formation

The orderly movement of a cell from one site to another that will contribute to the formation of an endocardial cushion. The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves.


Fc-gamma receptor signaling pathway

biolink:Pathway biolink:BiologicalProcess biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:NamedThing biolink:OntologyClass biolink:Occurrent biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

The series of molecular signals initiated by the binding of the Fc portion of immunoglobulin G (IgG) to an Fc-gamma receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. The Fc portion of an immunoglobulin is its C-terminal constant region.


multinuclear osteoclast differentiation

The process in which a relatively unspecialized monocyte acquires the specialized features of a multinuclear osteoclast. An osteoclast is a specialized phagocytic cell associated with the absorption and removal of the mineralized matrix of bone tissue.


positive regulation of cytochrome-c oxidase activity

Any process that activates or increases the frequency, rate or extent of cytochrome-c oxidase activity.


superior olivary complex

biolink:AnatomicalEntity biolink:OrganismalEntity biolink:BiologicalEntity biolink:NamedThing biolink:PhysicalEssence biolink:SubjectOfInvestigation biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

A collection of brainstem nuclei that functions in multiple aspects of hearing and is an important component of the ascending and descending auditory pathways of the auditory system.


L-amino acid transport

The directed movement of L-enantiomer amino acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


regulation of mammary gland epithelial cell proliferation

Any process that modulates the frequency, rate or extent of mammary gland epithelial cell proliferation.


epithelial cell differentiation involved in mammary gland alveolus development

The process in which a relatively unspecialized epithelial cell becomes a more specialized epithelial cell of the mammary gland alveolus.


hematopoietic system

Anatomical system that is involved in the production of hematopoietic cells.


red nucleus

Large round nucleus located in the midbrain tegmentum, consisting of a magnocellular and parvicellular portion in most species studied.


rhombomere 3 lateral wall

A rhombomere lateral wall that is part of a rhombomere 3.


lipase activator activity

Binds to and increases the activity of a lipase, an enzyme that catalyzes of the hydrolysis of a lipid.


The myristoylation of the N-terminal glycine of proteins to form the derivative N-myristoyl-glycine.


N-terminal protein myristoylation

The covalent attachment of a myristoyl group to the N-terminal amino acid residue of a protein.


positive regulation of high voltage-gated calcium channel activity

Any process that activates or increases the frequency, rate or extent of high voltage-gated calcium channel activity.


voltage-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential

Any voltage-gated ion channel activity that is involved in regulation of postsynaptic membrane potential.


hormone binding

Binding to an hormone, a naturally occurring substance secreted by specialized cells that affect the metabolism or behavior of cells possessing functional receptors for the hormone. Hormones may be produced by the same, or different, cell as express the receptor.


olfactory receptor activity

Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell.


chondroitin sulfate proteoglycan binding

Binding to a chondroitin sulfate proteoglycan, any proteoglycan containing chondroitin sulfate as the glycosaminoglycan carbohydrate unit.


CSPG2_MOUSE Versican core protein (sprot)

A versican core protein that is encoded in the genome of mouse.


regulation of immune system process

Any process that modulates the frequency, rate, or extent of an immune system process.


mitochondrion distribution

Any process that establishes the spatial arrangement of mitochondria between and within cells.


sarcoplasmic reticulum calcium ion transport

The directed movement of calcium ions (Ca2+) into, out of or within the sarcoplasmic reticulum.


kidney proximal convoluted tubule epithelial cell

biolink:Cell biolink:AnatomicalEntity biolink:OrganismalEntity biolink:BiologicalEntity biolink:NamedThing biolink:PhysicalEssence biolink:SubjectOfInvestigation biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent


regulation of CD8-positive, alpha-beta T cell differentiation

Any process that modulates the frequency, rate, or extent of CD8-positive, alpha-beta T cell differentiation.


regulation of guanylate cyclase activity

Any process that modulates the frequency, rate or extent of guanylate cyclase activity.


guanylate cyclase regulator activity

Modulates the activity of guanylate cyclase.


calcium sensitive guanylate cyclase activator activity

Binds to and increases the activity of guanylate cyclase in response to a change in calcium ion concentration.


EMAL4_HUMAN Echinoderm microtubule-associated protein-like 4 (sprot)

An echinoderm microtubule-associated protein-like 4 that is encoded in the genome of human.


mesenchymal stem cell maintenance involved in nephron morphogenesis

The process in which an organism retains a population of mesenchymal stem cells that contributes to the shaping of a nephron. A mesenchymal stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized mesenchymal cells.


exonuclease activity

Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' or 5' end.


flap endonuclease activity

Catalysis of the cleavage of a flap structure in DNA, but not other DNA structures; processes the ends of Okazaki fragments in lagging strand DNA synthesis.


manganese ion binding

Binding to a manganese ion (Mn).


planar cell polarity pathway involved in cardiac muscle tissue morphogenesis

The series of molecular signals initiated by binding of a Wnt protein to a receptor on the surface of the target cell where activated receptors signal via downstream effectors including C-Jun N-terminal kinase (JNK) to modulate cytoskeletal elements and control cell polarity that contributes to the shaping of the cardiac muscle tissue.


SUN domain-containing protein 1 isoform m5 (mouse)

A SUN domain-containing protein 1 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9D666-5.


cellular heat acclimation

Any process that increases heat tolerance of a cell in response to high temperatures.


cardiac left ventricle morphogenesis

The process in which the left cardiac ventricle is generated and organized.


fibroblast growth factor production

The appearance of a fibroblast growth factor due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.


positive regulation of fibroblast growth factor production

Any process that increases the rate, frequency or extent of the appearance of a fibroblast growth factor due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.


adiponectin-activated signaling pathway

The series of molecular signals initiated by adiponectin binding to its receptor on the surface of a cell, and ending with the regulation of a downstream cellular process, e.g. transcription.


negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator

Any process that stops, prevents or reduces the frequency, rate or extent of intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator.


negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress

Any process that stops, prevents or reduces the frequency, rate or extent of intrinsic apoptotic signaling pathway in response to osmotic stress.


determination of bilateral symmetry

The establishment of an organism's body plan or part of an organism with respect to a single longitudinal plane. The pattern can either be symmetric, such that the halves are mirror images, or asymmetric where the pattern deviates from this symmetry.


response to peptide hormone

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptide hormone stimulus. A peptide hormone is any of a class of peptides that are secreted into the blood stream and have endocrine functions in living animals.


activin binding

Binding to activin, a dimer of inhibin-beta subunits.


sperm ejaculation

The expulsion of seminal fluid, thick white fluid containing spermatozoa, from the male genital tract.


activin receptor binding

Binding to an activin receptor.


INHBA_MOUSE Inhibin beta A chain (sprot)

An activin/inhibin beta A chain that is encoded in the genome of mouse.


regulation of hair follicle cell proliferation

Any process that modulates the frequency, rate or extent of hair follicle cell proliferation.


positive regulation of cell maturation

Any process that activates or increases the frequency, rate or extent of cell maturation.


corticotrophin-releasing factor receptor activity

Combining with the corticotrophin-releasing factor family of ligands, including the urocortins, to initiate a change in cell activity.


myosin heavy chain binding

Binding to a heavy chain of a myosin complex.


MYH6_MOUSE Myosin-6 (sprot)

A myosin-6 that is encoded in the genome of mouse.


MYO19_MOUSE Unconventional myosin-XIX (sprot)

A myosin-XIX that is encoded in the genome of mouse.


PTPRF_MOUSE Receptor-type tyrosine-protein phosphatase F (sprot)

A receptor-type tyrosine-protein phosphatase F that is encoded in the genome of mouse.


DUS3_MOUSE Dual specificity protein phosphatase 3 (sprot)

A dual specificity protein phosphatase 3 that is encoded in the genome of mouse.


thioether S-methyltransferase activity

Catalysis of the reaction: S-adenosyl-L-methionine(1+) + dimethyl sulfide = S-adenosyl-L-homocysteine + trimethylsulfonium.


vitamin E biosynthetic process

The chemical reactions and pathways resulting in the formation of vitamin E, tocopherol, which includes a series of eight structurally similar compounds. Alpha-tocopherol is the most active form in humans and is a powerful biological antioxidant.


negative regulation of post-translational protein modification

Any process that stops, prevents or reduces the frequency, rate or extent of post-translational protein modification.


positive regulation of reciprocal meiotic recombination

Any process that increases the frequency, rate or extent of recombination during meiosis. Reciprocal meiotic recombination is the cell cycle process in which double strand breaks are formed and repaired through a double Holliday junction intermediate.


histone lysine demethylation

The modification of a histone by the removal of a methyl group from a lysine residue.


negative regulation of type B pancreatic cell apoptotic process

Any process that stops, prevents or reduces the frequency, rate or extent of type B pancreatic cell apoptotic process.


negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway

Any process that stops, prevents or reduces the frequency, rate or extent of an endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway.


positive regulation of type B pancreatic cell apoptotic process

Any process that activates or increases the frequency, rate or extent of type B pancreatic cell apoptotic process.


prostaglandin J receptor activity

Combining with prostaglandin J (PGJ(2)), a metabolite of prostaglandin D (PGD(2)) to initiate a change in cell activity.


prostaglandin D receptor activity

Combining with prostaglandin D (PGD(2)) to initiate a change in cell activity.


cellular response to prostaglandin D stimulus

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a prostagladin D stimulus.


melatonin receptor activity

Combining with melatonin, N-acetyl-5-methoxytryptamine, to initiate a change in cell activity. Melatonin is a neuroendocrine substance that stimulates the aggregation of melanosomes in melanophores, thus lightening the skin.


dynein intermediate chain binding

Binding to an intermediate chain of the dynein complex.


dynactin binding

Binding to a dynactin complex; a large protein complex that activates dynein-based motor activity.


single-celled organism vegetative growth phase

A phase of population growth during which single celled organisms reproduce by budding, fission, or other asexual methods.


positive regulation of protein O-linked glycosylation

Any process that activates or increases the frequency, rate or extent of protein O-linked glycosylation.


regulation of defense response to virus by host

Any host process that modulates the frequency, rate, or extent of the antiviral response of a host cell or organism.


CD8-positive, alpha-beta memory T cell

A CD8-positive, alpha-beta T cell that has differentiated into a memory T cell.


positive regulation of pancreatic amylase secretion

Any process that activates or increases the frequency, rate or extent of pancreatic amylase secretion.


calcium-mediated signaling using intracellular calcium source

The series of molecular signals in which a cell uses calcium ions released from an intracellular store to convert a signal into a response.


spine apparatus membrane

The lipid bilayer surrounding the spine apparatus.


postsynaptic recycling endosome membrane

The lipid bilayer surrounding a postsynaptic recycling endosome.


extrinsic component of postsynaptic density membrane

The component of the postsynaptic density membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region.


extrinsic component of postsynaptic early endosome membrane

The component of the postsynaptic early endosome membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region.


postsynaptic Golgi apparatus

The network of the Golgi apparatus structures located within the postsynapse.


postsynaptic endocytic zone membrane

The region of the postsynaptic membrane that is part of the postsynaptic endocytic zone. This region of membrane is associated with stable clathrin puncta.


postsynaptic septin cytoskeleton

The portion of the septin cytoskeleton contained within the postsynapse.


modification of postsynaptic actin cytoskeleton

Any process that modifies the structure of a postsynaptic actin cytoskeleton.


trans-synaptic signaling by trans-synaptic complex, modulating synaptic transmission

Cell-cell signaling between presynapse and postsynapse, mediated by transynaptic protein complexes, that modulates the synaptic transmission properties of the synapse.


postsynaptic dense core vesicle exocytosis

The secretion of molecules (e.g. neuropeptides, insulin-related peptides or neuromodulators such as serotonin and dopamine) contained within a postsynaptic dense core vesicle by fusion of the granule with the plasma membrane of the postsynapse in response to increased cytosolic calcium levels.


regulation of recycling endosome localization within postsynapse

Any process that modulates the frequency, rate or extent of transport or maintenance of location of a postsynaptic recycling endosome within the postsynapse.


regulation of neurotransmitter receptor transport, endosome to postsynaptic membrane

Any process that modulates the frequency, rate or extent of the directed movement of neurotransmitter receptor from the postsynaptic endosome to the postsynaptic membrane in transport vesicles.


maintenance of postsynaptic specialization structure

A process which maintains the organization and the arrangement of proteins in the presynaptic specialization.


modification of synaptic structure

Any process that modifies the structure/morphology of a synapse.


synaptic vesicle recycling via endosome

Synaptic vesicle recycling where vesicles endocytosed via clathrin-coated pits re-acidify and refill with neurotransmitters after passing through an endosomal intermediate.


neurotransmitter receptor transport, endosome to plasma membrane

The directed movement of neurotransmitter receptor from the endosome to the plasma membrane in transport vesicles.


neurotransmitter receptor transport to postsynaptic membrane

The directed movement of neurotransmitter receptor to the postsynaptic membrane in transport vesicles.


establishment of endoplasmic reticulum localization to postsynapse

The directed movement of endoplasmic reticulum into a postsynaptic compartment such as a dendritic spine.


retrograde trans-synaptic signaling by nitric oxide, modulating synaptic transmission

Modulation of synaptic transmission by cell-cell signaling from postsynapse to presynapse, across the synaptic cleft, mediated by nitric oxide.


calcium ion binding involved in regulation of postsynaptic cytosolic calcium ion concentration

The directed change of free calcium ion concentration in the postsynaptic cytosol via the reversible binding of calcium ions to calcium-binding proteins in the cytosol thereby modulating the spatial and temporal dynamics of changes in postsynaptic cytosolic calcium concentrations.


postsynaptic neurotransmitter receptor diffusion trapping

The process by which diffusing neurotransmitter receptor becomes trapped at the postsynaptic specialization membrane. This is typically due to interaction with components of the post-synaptic specialization.


maintenance of postsynaptic density structure

A process which maintains the organization and the arrangement of proteins in the presynaptic density.


anterograde dendritic transport

The directed movement of organelles or molecules along microtubules from the cell body toward the postsynapse in dendrites.


postsynaptic membrane assembly

The aggregation, arrangement and bonding together of a set of components to form a postsynaptic membrane, a specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft).


regulation of translation at postsynapse

Any process that regulates translation occurring at the postsynapse.


synapse pruning

A cellular process that results in the controlled breakdown of synapse. After it starts the process is continuous until the synapse has disappeared.


regulation of synaptic signaling by nitric oxide

Any process that modulates the frequency, rate or extent of synaptic signaling by nitric oxide.


presynapse to nucleus signaling pathway

The series of molecular signals that conveys information from the presynapse to the nucleus via cytoskeletal transport of a protein from a presynapse to the component to the nucleus where it affects biochemical processes that occur in the nucleus (e.g DNA transcription, mRNA splicing, or DNA/histone modifications).


RNA polyadenylation at postsynapse

A polyadenylation event (the enzymatic addition of a sequence of adenylyl residues at the 3' end of an RNA molecule) that takes place at a postsynapse.


regulation of exocytic insertion of neurotransmitter receptor to postsynaptic membrane

Any process that modulates the frequency, rate or extent of exocytic fusion of neurotransmitter receptor containing vesicles into the postsynaptic membrane.


regulation of protein catabolic process at presynapse, modulating synaptic transmission

Any process that modulates synaptic transmission by regulating a catabolic process occurring at a presynapse.


protein catabolic process, modulating synaptic transmission

Any protein degradation process, occurring at a presynapse, that regulates synaptic transmission.


NPTX2_HUMAN Neuronal pentraxin-2 (sprot)

A neuronal pentraxin-2 that is encoded in the genome of human.


NPTX1_HUMAN Neuronal pentraxin-1 (sprot)

A neuronal pentraxin-1 that is encoded in the genome of human.


IRPL2_HUMAN X-linked interleukin-1 receptor accessory protein-like 2 (sprot)

An X-linked interleukin-1 receptor accessory protein-like 2 that is encoded in the genome of human.


PTPRD_HUMAN Receptor-type tyrosine-protein phosphatase delta (sprot)

A receptor-type tyrosine-protein phosphatase delta that is encoded in the genome of human.


CCG5_HUMAN Voltage-dependent calcium channel gamma-5 subunit (sprot)

A voltage-dependent calcium channel gamma-5 subunit that is encoded in the genome of human.


ITB3_HUMAN Integrin beta-3 (sprot)

An integrin beta-3 that is encoded in the genome of human.


SLIK1_HUMAN SLIT and NTRK-like protein 1 (sprot)

A SLIT and NTRK-like protein 1 that is encoded in the genome of human.


SLIK2_HUMAN SLIT and NTRK-like protein 2 (sprot)

A SLIT and NTRK-like protein 2 that is encoded in the genome of human.


SLIK4_HUMAN SLIT and NTRK-like protein 4 (sprot)

A SLIT and NTRK-like protein 4 that is encoded in the genome of human.


Q2PYT4_RAT Tyrosine-protein kinase (Fragment) (trembl)


neuregulin-1 type I-beta1a (human)

A neuregulin-1 type I-beta1a that is encoded in the genome of human.


B2RYG4_RAT Kaptin (Actin binding protein) (Predicted), isoform CRA_a (trembl)


SPTB1_HUMAN Spectrin beta chain, erythrocytic (sprot)

A spectrin beta chain, erythrocytic that is encoded in the genome of human.


actomyosin structure organization

A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures containing both actin and myosin or paramyosin. The myosin may be organized into filaments.


positive regulation of peptidyl-tyrosine autophosphorylation

Any process that activates or increases the frequency, rate or extent of peptidyl-tyrosine autophosphorylation.


epithelial cell differentiation involved in salivary gland development

The process in which a relatively unspecialized cell acquire specialized structural and/or functional features of an epithelial cell of the salivary gland.


BH4 domain binding

Binding to a BH4 protein domain, present in Bcl-2 family members. All anti-apoptotic proteins contain BH1 and BH2 domains; some also contain an additional N-terminal BH4 domain, which is almost never seen in pro-apoptotic proteins. Loss of the BH4 domain can diminish or abrogate anti-apoptotic function or even impart outright death-promoting properties to the protein.


neural fold elevation formation

The process in which the lateral borders of the neural plate begin to migrate upwards to form the neural folds, caused by the proliferation of the underlying mesoderm.


heat shock protein HSP 90-alpha, initiator methionine removed non-ubiquitinated 1 (mouse)

A heat shock protein HSP 90-alpha, initiator methionine removed form in mouse that lacks cross-linking to K63-linked polyubiquitin on one or more Lys residues by Hectd1.


delta-catenin binding

Binding to the delta subunit of the catenin complex.


regulation of protein localization to cell surface

Any process that modulates the frequency, rate or extent of protein localization to the cell surface.


apoptosis regulator BAX isoform Alpha (mouse)

An apoptosis regulator BAX isoform 1 that is encoded in the genome of mouse.


JIP4_HUMAN C-Jun-amino-terminal kinase-interacting protein 4 (sprot)

A C-Jun-amino-terminal kinase-interacting protein 4 that is encoded in the genome of human.


CDON_HUMAN Cell adhesion molecule-related/down-regulated by oncogenes (sprot)

A cell adhesion molecule-related/down-regulated by oncogenes that is encoded in the genome of human.


BNIP2_HUMAN BCL2/adenovirus E1B 19 kDa protein-interacting protein 2 (sprot)

A BCL2/adenovirus E1B 19 kDa protein-interacting protein 2 that is encoded in the genome of human.


brother of CDO isoform h1 (human)

A brother of CDO (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9BWV1-1.


mast cell activation

The change in morphology and behavior of a mast cell resulting from exposure to a cytokine, chemokine, soluble factor, or to (at least in mammals) an antigen which the mast cell has specifically bound via IgE bound to Fc-epsilonRI receptors.


cell-cell adhesion involved in neuronal-glial interactions involved in cerebral cortex radial glia guided migration

The interaction between two cells that modulates the association of a neuronal cell and a glial cell involved in glial-mediated radial cell migration in the cerebral cortex.


positive regulation of small GTPase mediated signal transduction

Any process that activates or increases the frequency, rate or extent of small GTPase mediated signal transduction.


GABAergic neuron differentiation in basal ganglia

The process in which a neuroblast acquires the specialized structural and functional features of a GABAergic inhibitory neuron in the basal ganglia. Differentiation includes the processes involved in commitment of a neuroblast to a GABAergic neuron.


ERBB4_MOUSE Receptor tyrosine-protein kinase erbB-4 (sprot)

A receptor tyrosine-protein kinase erbB-4 that is encoded in the genome of mouse.


response to interleukin-15

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-15 stimulus.


development of secondary male sexual characteristics

The process whose specific outcome is the progression of the secondary male sexual characteristics over time, from their formation to the mature structures. In male humans, these include growth of axillary, chest, and pubic hair, voice changes, and testicular/penile enlargement. Development occurs in response to sex hormone secretion.


response to interleukin-2

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-2 stimulus.


response to interleukin-4

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-4 stimulus.


development of secondary female sexual characteristics

The process whose specific outcome is the progression of the secondary female sexual characteristics over time, from their formation to the mature structures. In female humans, these include growth of axillary and pubic hair, breast development and menstrual periods. Their development occurs in response to sex hormone secretion.


mast cell migration

The movement of a mast cell within or between different tissues and organs of the body.


negative regulation of mast cell apoptotic process

Any process that stops, prevents, or reduces the frequency, rate, or extent of mast cell apoptotic process.


positive regulation of mast cell proliferation

Any process that activates or increases the rate or extent of mast cell proliferation.


positive regulation of mast cell differentiation

Any process that increases the rate, frequency or extent of mast cell differentiation, the process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of a mast cell. A mast cell is a cell that is found in almost all tissues containing numerous basophilic granules and capable of releasing large amounts of histamine and heparin upon activation.


lumenal side of endoplasmic reticulum membrane

The side (leaflet) of the plasma membrane that faces the lumen.


LAG3_HUMAN Lymphocyte activation gene 3 protein (sprot)

A lymphocyte activation gene 3 protein that is encoded in the genome of human.


DRA_HUMAN HLA class II histocompatibility antigen, DR alpha chain (sprot)

An MHC class II histocompatibility antigen alpha chain DRA that is encoded in the genome of human.


DQA2_HUMAN HLA class II histocompatibility antigen, DQ alpha 2 chain (sprot)

An MHC class II histocompatibility antigen alpha chain DQA2 that is encoded in the genome of human.


DQA1_HUMAN HLA class II histocompatibility antigen, DQ alpha 1 chain (sprot)

An MHC class II histocompatibility antigen alpha chain DQA1 that is encoded in the genome of human.


DRB1_HUMAN HLA class II histocompatibility antigen, DRB1 beta chain (sprot)

An MHC class II histocompatibility antigen beta chain DRB1 that is encoded in the genome of human.


DQB1_HUMAN HLA class II histocompatibility antigen, DQ beta 1 chain (sprot)

An MHC class II histocompatibility antigen beta chain DQB1 that is encoded in the genome of human.


DPB1_HUMAN HLA class II histocompatibility antigen, DP beta 1 chain (sprot)

An MHC class II histocompatibility antigen beta chain DPB1 that is encoded in the genome of human.


DQB2_HUMAN HLA class II histocompatibility antigen, DQ beta 2 chain (sprot)

An MHC class II histocompatibility antigen beta chain DQB2 that is encoded in the genome of human.


DRB4_HUMAN HLA class II histocompatibility antigen, DR beta 4 chain (sprot)

An MHC class II histocompatibility antigen beta chain DRB4 that is encoded in the genome of human.


DPA1_HUMAN HLA class II histocompatibility antigen, DP alpha 1 chain (sprot)

An MHC class II histocompatibility antigen alpha chain DPA1 that is encoded in the genome of human.


DRB3_HUMAN HLA class II histocompatibility antigen, DR beta 3 chain (sprot)

An MHC class II histocompatibility antigen beta chain DRB3 that is encoded in the genome of human.


DRB5_HUMAN HLA class II histocompatibility antigen, DR beta 5 chain (sprot)

An MHC class II histocompatibility antigen beta chain DRB5 that is encoded in the genome of human.


antigen processing and presentation of peptide antigen

The process in which an antigen-presenting cell expresses peptide antigen in association with an MHC protein complex on its cell surface, including proteolysis and transport steps for the peptide antigen both prior to and following assembly with the MHC protein complex. The peptide antigen is typically, but not always, processed from an endogenous or exogenous protein.


cyclin-dependent protein kinase activity

Cyclin-dependent catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP.


xanthophyll

A subclass of carotenoids consisting of the oxygenated carotenes.


R-SMAD binding

Binding to a receptor-regulated SMAD signaling protein.


DRD5_MACMU D(1B) dopamine receptor (Fragment) (sprot)


CAC1B_CHICK Voltage-dependent N-type calcium channel subunit alpha-1B (Fragment) (sprot)


dynein light intermediate chain binding

Binding to a light intermediate chain of the dynein complex.


IDLC_MOUSE Axonemal dynein light intermediate polypeptide 1 (sprot)

An axonemal dynein light intermediate polypeptide 1 that is encoded in the genome of mouse.


kidney loop of Henle medullary thick ascending limb epithelial cell

An epithelial cell that is part of some loop of Henle thick ascending limb segment located in the renal medulla.


solute carrier family 12 member 1 isoform A (mouse)

A solute carrier family 12 member 1 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P55014-1.


glycerol transmembrane transport

The directed movement of glycerol across a membrane. Glycerol is 1,2,3-propanetriol, a sweet, hygroscopic, viscous liquid, widely distributed in nature as a constituent of many lipids.


gallbladder primordium

A sac-like cavity ventral to the liver, lying in the sub-mesodermal space and closed by a thin sheet of ectodermal cells, from which the future gall bladder develops.


taste receptor binding

Binding to a taste receptor.


mitotic DNA damage checkpoint signaling

A signal transduction process involved in mitotic DNA damage checkpoint.


protein localization to nuclear pore

A process in which a protein is transported to, or maintained in, a nuclear pore.


7SK snRNA binding

Binding to a 7SK small nuclear RNA (7SK snRNA).


antibacterial peptide secretion

The regulated release of an antibacterial peptide from a cell or a tissue.


salivary gland glandular cell

Glandular cell of salivary gland. Example: Serous cells, mucous cells, cuboidal epithelial cells of the intercalated ducts, simple cuboidal epithelium of the striated ducts, epithelial cells of excretory ducts.


enterocyte of epithelium of small intestine

An enterocyte that is part of the epithelium of small intestine.


desmosome organization

A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a desmosome. A desmosome is a patch-like intercellular junction found in vertebrate tissues, consisting of parallel zones of two cell membranes, separated by an space of 25-35 nm, and having dense fibrillar plaques in the subjacent cytoplasm.


cysteine-type endopeptidase activity involved in apoptotic signaling pathway

Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile, and contributing to the apoptotic signaling pathway.


Catalysis of the reaction: CMP-N-acetylneuraminate + NADPH + H+ + O2 = CMP-N-glycoloylneuraminate + NADP+ + H2O.


The chemical reactions and pathways involving CMP-N-acetylneuraminate, a substance composed of 5-(acetylamino)-3,5-dideoxy-D-glycero-D-galacto-non-3-ulosonic acid in glycosidic linkage with cytidine monophosphate.


HES1_MOUSE Transcription factor HES-1 (sprot)

A transcription factor HES-1 that is encoded in the genome of mouse.


The directed, sodium-independent, movement of prostaglandins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


dense core granule membrane

The lipid bilayer surrounding a dense core granule.


corticotropin secretion

The regulated release of corticotropin by a cell. Corticotropin hormone is a polypeptide hormone synthesized and secreted from corticotropes in the anterior lobe of the pituitary gland in response to corticotropin-releasing hormone (CRH) released by the hypothalamus.


iron import into cell

The directed movement of iron ions from outside of a cell into the cytoplasmic compartment. This may occur via transport across the plasma membrane or via endocytosis.


positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway

Any process that activates or increases the frequency, rate or extent of cysteine-type endopeptidase activity involved in apoptotic signaling pathway.


male germ-line stem cell asymmetric division

The self-renewing division of a germline stem cell in the male gonad, to produce a daughter stem cell and a daughter germ cell, which will divide to form the male gametes.


Cul2-RING ubiquitin ligase complex

A ubiquitin ligase complex in which a cullin from the Cul2 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by an elongin-BC adaptor and a SOCS/BC box protein.


negative regulation of growth

Any process that stops, prevents or reduces the rate or extent of growth, the increase in size or mass of all or part of an organism.


Catalysis of the reactions: D-myo-inositol 1,4,5-trisphosphate + H2O = myo-inositol 1,4-bisphosphate + phosphate, and 1D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O = 1D-myo-inositol 1,3,4-trisphosphate + phosphate.


regulation of Rho protein signal transduction

Any process that modulates the frequency, rate or extent of Rho protein signal transduction.


T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell

The change in morphology and behavior of a mature or immature T cell resulting from exposure to an antigen for which its T cell receptor is specific bound to an MHC molecule on an antigen presenting cell, leading to the initiation or perpetuation of an immune response.


negative regulation of macrophage antigen processing and presentation

Any process that stops, prevents, or reduces the frequency, rate, or extent of macrophage antigen processing and presentation.


negative regulation of memory T cell differentiation

Any process that stops, prevents, or reduces the rate of memory T cell differentiation.


negative regulation of dendritic cell antigen processing and presentation

Any process that stops, prevents, or reduces the frequency, rate, or extent of dendritic cell antigen processing and presentation.


DNJA1_MOUSE DnaJ homolog subfamily A member 1 (sprot)

A DnaJ homolog subfamily A member 1 that is encoded in the genome of mouse.


positive regulation of vascular permeability

Any process that increases the extent to which blood vessels can be pervaded by fluid.


vascular endothelial growth factor receptor 1 binding

Binding to a vascular endothelial growth factor receptor 1.


semaphorin receptor binding

Binding to a semaphorin receptor.


PLGF_HUMAN Placenta growth factor (sprot)

A placenta growth factor that is encoded in the genome of human.


ERBB3_MOUSE Receptor tyrosine-protein kinase erbB-3 (sprot)

A receptor tyrosine-protein kinase erbB-3 that is encoded in the genome of mouse.


epidermal growth factor receptor phosphorylated form (mouse)

An epidermal growth factor receptor (mouse) that includes at least one phosphorylated tyrosine. UniProtKB:Q01279, MOD:00048.


receptor tyrosine-protein kinase erbB-4 phosphotyrosine form (mouse)

A receptor tyrosine-protein kinase erbB-4 (mouse) that includes at least one phosphorylated tyrosine. UniProtKB:Q61527, MOD:00048.


receptor tyrosine-protein kinase erbB-2 phosphotyrosine form (mouse)

A receptor tyrosine-protein kinase erbB-2 (mouse) that includes at least one phosphorylated tyrosine. UniProtKB:P70424, MOD:00048.


defense response to nematode

A response to protect an organism from a directly detected or perceived external threat from a nematode or nematodes, which results in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack.


phosphatidylcholine:ceramide cholinephosphotransferase 1 isoform 1 (mouse)

A phosphatidylcholine:ceramide cholinephosphotransferase 1 isoform 1 that is encoded in the genome of mouse.


metanephric nephron tubule epithelial cell differentiation

The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells of the metanephric nephron tubule as it progresses from its formation to the mature state.


negative regulation of cell adhesion involved in substrate-bound cell migration

The disassembly of adhesions at the front and rear of a migrating cell. At the leading edge, adhesion disassembly accompanies the formation of new protrusions; at the cell rear, it promotes tail retraction.


respiratory burst after phagocytosis

A phase of elevated metabolic activity, during which oxygen consumption increases, that occurs in neutrophils, monocytes, and macrophages shortly after phagocytosing material. An enhanced uptake of oxygen leads to the production, by an NADH dependent system, of hydrogen peroxide (H2O2), superoxide anions and hydroxyl radicals, which play a part in microbiocidal activity.


negative regulation of hair follicle placode formation

Any process that decreases the rate, frequency, or extent of hair follicle placode formation, the developmental process in which a hair placode forms. An hair follicle placode is a thickening of the ectoderm that will give rise to the hair follicle bud.


fungiform papilla development

The progression of the fungiform papilla over time, from its formation to the mature structure. The fungiform papilla is a mushroom-shaped papilla of the tongue.


endopeptidase activator activity

Binds to and increases the activity of an endopeptidase.


antigen processing and presentation of exogenous antigen

The process in which an antigen-presenting cell expresses antigen (peptide or lipid) of exogenous origin on its cell surface in association with an MHC protein complex.


positive regulation of reactive oxygen species biosynthetic process

Any process that activates or increases the frequency, rate or extent of reactive oxygen species biosynthetic process.


triglyceride mobilization

The release of triglycerides, any triester of glycerol, from storage within cells or tissues, making them available for metabolism.


regulation of lipoprotein metabolic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving lipoproteins, any conjugated, water-soluble protein in which the nonprotein group consists of a lipid or lipids.


arylesterase activity

Catalysis of the reaction: a phenyl acetate + H2O = a phenol + acetate.


nutrient reservoir activity

Functions in the storage of nutritious substrates.


cAMP metabolic process

The chemical reactions and pathways involving the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate).


flotillin complex

A protein complex that contains flotillin-1 and flotillin-2, and may contain associated proteins. Flotillins associate into membrane microdomains resembling caveolae.


regulation of actin binding

Any process that modulates the frequency, rate or extent of actin binding.


paracrine signaling

The transfer of information from one cell to another, where the signal travels from the signal-producing cell to the receiving cell by passive diffusion or bulk flow in intercellular fluid. The signaling cell and the receiving cell are usually in the vicinity of each other.


respiratory basal cell differentiation

The process in which a relatively unspecialized cell acquires the specialized features of a respiratory basal cell.


alveolar lamellar body

A specialized secretory organelle found in type II pneumocytes and involved in the synthesis, secretion, and reutilization of pulmonary surfactant.


negative regulation of mesenchymal cell apoptotic process involved in nephron morphogenesis

Any process that reduces the occurrence or rate of mesenchymal stem cell death by apoptotic process that contributes to the shaping of the nephron.


branch elongation of an epithelium

The growth process in which a branch increases in length from its base to its tip.


entry of viral genome into host nucleus through nuclear pore complex via importin

Viral penetration into the host nucleus where the viral genome passes through the nuclear pore complex (NPC) using the cellular importin transport machinery.


central nervous system interneuron axonogenesis

Generation of a long process that carries efferent (outgoing) action potentials from the cell body towards target cells from a neuron located in the central nervous system whose axons remain within a single brain region.


adipose macrophage

A macrophage located in adipose tissue that is CD45-positive, CD11c-positive, and SIRPa-positive.


midgut development

The process whose specific outcome is the progression of the midgut over time, from its formation to the mature structure. The midgut is the middle part of the alimentary canal from the stomach, or entrance of the bile duct, to, or including, the large intestine.


stem cell fate specification

The process in which a cell becomes capable of differentiating autonomously into a stem cell in an environment that is neutral with respect to the developmental pathway. Upon specification, the cell fate can be reversed.


B2MVI1_LAMFL Epsin 1 (Fragment) (trembl)


AP2B1_HUMAN AP-2 complex subunit beta (sprot)

An AP-2 complex subunit beta that is encoded in the genome of human.


AP2M1_HUMAN AP-2 complex subunit mu (sprot)

An AP-2 complex subunit mu that is encoded in the genome of human.


AP2S1_HUMAN AP-2 complex subunit sigma (sprot)

An AP-2 complex subunit sigma that is encoded in the genome of human.


TSN7_HUMAN Tetraspanin-7 (sprot)

A tetraspanin-7 that is encoded in the genome of human.


MERTK_HUMAN Tyrosine-protein kinase Mer (sprot)

A tyrosine-protein kinase Mer that is encoded in the genome of human.


JAM2_HUMAN Junctional adhesion molecule B (sprot)

A junctional adhesion molecule B that is encoded in the genome of human.


C99L2_HUMAN CD99 antigen-like protein 2 (sprot)

A CD99 molecule-like protein 2 that is encoded in the genome of human.


SELPL_HUMAN P-selectin glycoprotein ligand 1 (sprot)

A P-selectin glycoprotein ligand 1 that is encoded in the genome of human.


SLAF5_HUMAN SLAM family member 5 (sprot)

A SLAM family member 5 that is encoded in the genome of human.


FCAMR_HUMAN High affinity immunoglobulin alpha and immunoglobulin mu Fc receptor (sprot)

A high affinity immunoglobulin alpha and immunoglobulin mu Fc receptor that is encoded in the genome of human.


LYAM2_HUMAN E-selectin (sprot)

An E-selectin that is encoded in the genome of human.


CD2_HUMAN T-cell surface antigen CD2 (sprot)

A CD2 molecule that is encoded in the genome of human.


EPCAM_HUMAN Epithelial cell adhesion molecule (sprot)

An epithelial cell adhesion molecule that is encoded in the genome of human.


CD48_HUMAN CD48 antigen (sprot)

A CD48 molecule that is encoded in the genome of human.


CD244_HUMAN Natural killer cell receptor 2B4 (sprot)

A natural killer cell receptor 2B4 that is encoded in the genome of human.


LEUK_HUMAN Leukosialin (sprot)

A leukosialin that is encoded in the genome of human.


SIRPG_HUMAN Signal-regulatory protein gamma (sprot)

A signal-regulatory protein gamma that is encoded in the genome of human.


GLPA_HUMAN Glycophorin-A (sprot)

A glycophorin-A that is encoded in the genome of human.


GLPC_HUMAN Glycophorin-C (sprot)

A glycophorin-C that is encoded in the genome of human.


GLPB_HUMAN Glycophorin-B (sprot)

A glycophorin-B that is encoded in the genome of human.


CEAM5_HUMAN Carcinoembryonic antigen-related cell adhesion molecule 5 (sprot)

A carcinoembryonic antigen-related cell adhesion molecule 5 that is encoded in the genome of human.


OMPC_NEIGO Outer membrane protein P.IIC (sprot)


OPAC_NEIGO Opacity protein opA50 (Fragment) (sprot)


OP28_NEIGO Opacity protein V28 (Fragment) (sprot)


PSG1_HUMAN Pregnancy-specific beta-1-glycoprotein 1 (sprot)

A pregnancy-specific beta-1-glycoprotein 1 that is encoded in the genome of human.


PSG2_HUMAN Pregnancy-specific beta-1-glycoprotein 2 (sprot)

A pregnancy-specific beta-1-glycoprotein 2 that is encoded in the genome of human.


EBA1_PLAFC Erythrocyte-binding antigen 175 (sprot)


PSG9_HUMAN Pregnancy-specific beta-1-glycoprotein 9 (sprot)

A pregnancy-specific beta-1-glycoprotein 9 that is encoded in the genome of human.


PSG4_HUMAN Pregnancy-specific beta-1-glycoprotein 4 (sprot)

A pregnancy-specific beta-1-glycoprotein 4 that is encoded in the genome of human.


PSG6_HUMAN Pregnancy-specific beta-1-glycoprotein 6 (sprot)

A pregnancy-specific beta-1-glycoprotein 6 that is encoded in the genome of human.


OPAB_NEIGO Opacity protein opA51 (Fragment) (sprot)


OPAG_NEIGO Opacity protein opA52 (Fragment) (sprot)


OPAA_NEIGO Opacity protein opA53 (Fragment) (sprot)


OPAI_NEIGO Opacity protein opA54 (sprot)


OPAE_NEIGO Opacity protein opA55 (Fragment) (sprot)


OPAF_NEIGO Opacity protein opA56 (Fragment) (sprot)


OPAK_NEIGO Opacity protein opA57 (Fragment) (sprot)


OPA68_NEIGO Opacity protein opA68 (Fragment) (sprot)


OPAJ_NEIGO Opacity protein opA58 (sprot)


OPAD_NEIGO Opacity protein opA59 (Fragment) (sprot)


OPAH_NEIGO Opacity protein opA60 (Fragment) (sprot)


OPA65_NEIGO Opacity protein opA65 (Fragment) (sprot)


OPA66_NEIGO Opacity protein opA66 (Fragment) (sprot)


OPA67_NEIGO Opacity protein opA67 (Fragment) (sprot)


PSG7_HUMAN Pregnancy-specific beta-1-glycoprotein 7 (sprot)

A pregnancy-specific beta-1-glycoprotein 7 that is encoded in the genome of human.


PSG5_HUMAN Pregnancy-specific beta-1-glycoprotein 5 (sprot)

A pregnancy-specific beta-1-glycoprotein 5 that is encoded in the genome of human.


PSG3_HUMAN Pregnancy-specific beta-1-glycoprotein 3 (sprot)

A pregnancy-specific beta-1-glycoprotein 3 that is encoded in the genome of human.


Q76NM5_PLAF7 Erythrocyte binding antigen-140 (trembl)


GSLG1_HUMAN Golgi apparatus protein 1 (sprot)

A Golgi apparatus protein 1 that is encoded in the genome of human.


ESAM_HUMAN Endothelial cell-selective adhesion molecule (sprot)

An endothelial cell-selective adhesion molecule that is encoded in the genome of human.


Q9U4X0_PLAFA Putative erythrocyte binding protein EBL-1 (Fragment) (trembl)


PSG11_HUMAN Pregnancy-specific beta-1-glycoprotein 11 (sprot)

A pregnancy-specific beta-1-glycoprotein 11 that is encoded in the genome of human.


PSG8_HUMAN Pregnancy-specific beta-1-glycoprotein 8 (sprot)

A pregnancy-specific beta-1-glycoprotein 8 that is encoded in the genome of human.


UV protection

Any process in which an organism or cell protects itself from ultraviolet radiation (UV), which may also result in resistance to repeated exposure to UV.


regulation of RNA metabolic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving RNA.


prostaglandin E2 receptor EP3 subtype isoform Alpha (mouse)

A prostaglandin E2 receptor EP3 subtype isoform 1 that is encoded in the genome of mouse.


planar cell polarity pathway involved in ventricular septum morphogenesis

The series of molecular signals initiated by binding of a Wnt protein to a receptor on the surface of the target cell where activated receptors signal via downstream effectors including C-Jun N-terminal kinase (JNK) to modulate cytoskeletal elements and control cell polarity that contributes to the shaping of the ventricular septum.


ovulation cycle

The type of sexual cycle seen in females, often with physiologic changes in the endometrium that recur at regular intervals during the reproductive years.


negative regulation of substrate adhesion-dependent cell spreading

Any process that stops, prevents or reduces the frequency, rate or extent of substrate adhesion-dependent cell spreading.


Mullerian tubercle

An elevation on the wall of the embryonic urogenital sinus where the Müllerian ducts enter.


dosage compensation by inactivation of X chromosome

Compensating for the two-fold variation in X-chromosome:autosome ratios between sexes by a global inactivation of all, or most of, the genes on one of the X-chromosomes in the XX sex.


mature gamma-delta T cell

A gamma-delta T cell that has a mature phenotype. These cells can be found in tissues and circulation where they express unique TCR repertoire depending on their location.


positive regulation of protein localization to early endosome

Any process that activates or increases the frequency, rate or extent of protein localization to early endosome.


N-acetylglucosamine metabolic process

The chemical reactions and pathways involving N-acetylglucosamine. The D isomer is a common structural unit of glycoproteins in plants, bacteria and animals; it is often the terminal sugar of an oligosaccharide group of a glycoprotein.


syntaxin binding

Binding to a syntaxin, a SNAP receptor involved in the docking of synaptic vesicles at the presynaptic zone of a synapse.


metanephric glomerular basement membrane development

The process whose specific outcome is the progression of the metanephric glomerular basement membrane over time, from its formation to the mature structure. The metanephric glomerular basement membrane is the basal laminal portion of the metanephric glomerulus which performs the actual filtration.


plasma membrane tubulation

A membrane tubulation process occurring in a plasma membrane.


negative regulation of apoptotic process involved in morphogenesis

Any process that stops, prevents or reduces the frequency, rate or extent of apoptotic process involved in morphogenesis.


negative regulation of epithelial cell migration

Any process that stops, prevents, or reduces the frequency, rate or extent of epithelial cell migration.


ovarian cumulus expansion

Increase in size of the cumulus surrounding the oocyte including change in morphology due to proliferation and dispersion of cumulus cells.


(1->3)-beta-D-glucan binding

Binding to a (1->3)-beta-D-glucan.


extracellular matrix structural constituent conferring compression resistance

A constituent of the extracellular matrix that enables the matrix to resist compressive forces; often a proteoglycan.


regulation of signal transduction by receptor internalization

Any process that modulates the frequency, rate or extent of signal transduction by the movement of a signaling receptor from the plasma membrane to the inside of the cell. Receptor internalization can have a positive or negative effect on a signaling pathway.


regulation of nerve growth factor receptor activity

Any process that modulates the frequency, rate or extent of the activity of the nerve growth factor (NGF) receptor.


positive regulation of inner ear receptor cell differentiation

Any process that activates or increases the frequency, rate or extent of inner ear receptor cell differentiation.


positive regulation of MHC class I biosynthetic process

Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of MHC class I.


antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent

The process in which an antigen-presenting cell expresses a peptide antigen of exogenous origin on its cell surface in association with an MHC class Ib protein complex following intracellular transport via a TAP (transporter associated with antigen processing) pathway. The peptide is typically a fragment of a larger exogenous protein which has been degraded within the cell and is dependent on TAP transport from the cytosol to ER for association with the MHC class Ib molecule. Class Ib here refers to non-classical class I molecules, such as those of the HLA-E gene family.


antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent

The process in which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC class Ib protein complex following intracellular transport via a TAP (transporter associated with antigen processing) pathway. The peptide is typically a fragment of a larger endogenous protein which has been degraded within the cell and is dependent on TAP transport from the cytosol to ER for association with the MHC class Ib molecule. Class Ib here refers to non-classical class I molecules, such as those of the HLA-E gene family.


positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway

Any process that activates or increases the frequency, rate or extent of an oxidative stress-induced intrinsic apoptotic signaling pathway.


regulation of MHC class I biosynthetic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of MHC class I.


tumor protein p53-inducible nuclear protein 1 isoform 2 (mouse)

A tumor protein p53-inducible nuclear protein 1 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9QXE4-2.


nephrogenic zone

Outer portion of the renal cortex. Site of formation of medullary and cortical elements.


inferior colliculus development

The process whose specific outcome is the progression of the inferior colliculus over time, from its formation to the mature structure. The inferior colliculus (IC) (Latin, lower hill) is the principal midbrain nucleus of the auditory pathway and receives input from several more peripheral brainstem nuclei in the auditory pathway, as well as inputs from the auditory cortex. The inferior colliculus has three subdivisions: the central nucleus (CIC), a dorsal cortex (DCIC) by which it is surrounded, and an external cortex (ICX) which is located laterally.


olfactory nerve development

The process whose specific outcome is the progression of the olfactory nerve over time, from its formation to the mature structure. The olfactory nerve is a collection of sensory nerve rootlets that extend down from the olfactory bulb to the olfactory mucosa of the upper parts of the nasal cavity. This nerve conducts odor information to the brainstem.


regulation of synapse structure or activity

Any process that modulates the physical form or the activity of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell).


sialic acid binding

Binding to a sialic acid, a N- or O- substituted derivative of neuraminic acid, a nine carbon monosaccharide. Sialic acids often occur in polysaccharides, glycoproteins, and glycolipids in animals and bacteria.


cell-cell adhesion mediated by integrin

The attachment of one cell to another cell via an integrin, a heterodimeric adhesion receptor formed by the non-covalent association of particular alpha and beta subunits.


A 2-methylpentadecenoyl-CoA in which the double bond is located at position 2 (geochemistry not specified).


An unsaturated fatty acyl-CoA that results from the formal condensation of the thiol group of coenzyme A with the carboxy group of 2-docosenoic acid. The product of dehydrogenation of behenoyl-CoA


Behenyl-coenzyme A

A very long-chain fatty acyl-CoA that results from the formal condensation of the thiol group of coenzyme A with the carboxy group of docosanoic (behenic) acid.


A mono-unsaturated fatty acyl-CoA that results from the formal condensation of the thiol group of coenzyme A with the carboxy group of any 2-methylpentadecenoic acid.


ACPM_HUMAN Acyl carrier protein, mitochondrial (sprot)

An acyl carrier protein, mitochondrial that is encoded in the genome of human.


ABCA1_HUMAN Phospholipid-transporting ATPase ABCA1 (sprot)

A phospholipid-transporting ATPase ABCA1 that is encoded in the genome of human.


ANGL4_HUMAN Angiopoietin-related protein 4 (sprot)

An angiopoietin-related protein 4 that is encoded in the genome of human.


G0S2_HUMAN G0/G1 switch protein 2 (sprot)

A G0/G1 switch protein 2 that is encoded in the genome of human.


FHL2_HUMAN Four and a half LIM domains protein 2 (sprot)

A four and a half LIM domains protein 2 that is encoded in the genome of human.


PX11A_HUMAN Peroxisomal membrane protein 11A (sprot)

A peroxisomal membrane protein 11A that is encoded in the genome of human.


GRHL1_HUMAN Grainyhead-like protein 1 homolog (sprot)

A grainyhead-like protein 1 that is encoded in the genome of human.


ST2A1_HUMAN Sulfotransferase 2A1 (sprot)

A sulfotransferase 2A1 that is encoded in the genome of human.


MAOX_HUMAN NADP-dependent malic enzyme (sprot)

An NADP-dependent malic enzyme that is encoded in the genome of human.


ANKR1_HUMAN Ankyrin repeat domain-containing protein 1 (sprot)

An ankyrin repeat domain-containing protein 1 that is encoded in the genome of human.


ACADM_HUMAN Medium-chain specific acyl-CoA dehydrogenase, mitochondrial (sprot)

A medium-chain specific acyl-CoA dehydrogenase, mitochondrial that is encoded in the genome of human.


APOA2_HUMAN Apolipoprotein A-II (sprot)

An apolipoprotein A-II that is encoded in the genome of human.


TNR21_HUMAN Tumor necrosis factor receptor superfamily member 21 (sprot)

A tumor necrosis factor receptor superfamily member 21 that is encoded in the genome of human.


peroxisomal acyl-coenzyme A oxidase 1 isoform h1 (human)

A peroxisomal acyl-coenzyme A oxidase 1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q15067-1.


TBB3_MOUSE Tubulin beta-3 chain (sprot)

A tubulin beta-3 chain that is encoded in the genome of mouse.


mannosidase activity

Catalysis of the hydrolysis of mannosyl compounds, substances containing a group derived from a cyclic form of mannose or a mannose derivative.


hydrolase activity, hydrolyzing N-glycosyl compounds

Catalysis of the hydrolysis of any N-glycosyl bond.


blastocele

Fluid-filled central region of a blastocyst.


collagen type IV trimer

A collagen heterotrimer containing type IV alpha chains; [alpha1(IV)]2alpha2(IV) trimers are commonly observed, although more type IV alpha chains exist and may be present in type IV trimers; type IV collagen triple helices associate to form 3 dimensional nets within basement membranes.


chaperonin-containing T-complex

A multisubunit ring-shaped complex that mediates protein folding in the cytosol without a cofactor.


T-complex protein 1 subunit eta isoform 1 phosphorylated 1 (mouse)

A T-complex protein 1 subunit eta isoform 1 phosphorylated 1 in mouse. UniProtKB:P80313-1, Thr-57, MOD:00047|Ser-59, MOD:00046.


T-complex protein 1 subunit epsilon isoform 1 phosphorylated 1 (mouse)

A T-complex protein 1 subunit epsilon isoform 1 phosphorylated 1 in mouse. UniProtKB:P80316-1, Ser-270, MOD:00046.


Q99232_MOUSE Carcinoembryonic antigen family member protein (trembl)

A carcinoembryonic antigen-related cell adhesion molecule 1 sequence variant CEACAM1b (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q99232. This form contains the two copies of the Ig domain and is the version with shorter cytoplasmic tail.


negative regulation of molecular function

Any process that stops or reduces the rate or extent of a molecular function, an elemental biological activity occurring at the molecular level, such as catalysis or binding.


anterior neuropore closure

The joining together of the neural folds of the rostral opening of the neural tube. The anterior neuropore appears before the process of neural tube closure is complete.


negative regulation of wound healing

Any process that decreases the rate, frequency, or extent of the series of events that restore integrity to a damaged tissue, following an injury.


regulation of synaptic vesicle recycling

Any process that modulates the frequency, rate or extent of synaptic vesicle recycling.


cell killing

Any process in an organism that results in the killing of its own cells or those of another organism, including in some cases the death of the other organism. Killing here refers to the induction of death in one cell by another cell, not cell-autonomous death due to internal or other environmental conditions.


acetyl group

A group, formally derived from acetic acid by dehydroxylation, which is fundamental to the biochemistry of all forms of life. When bound to coenzyme A, it is central to the metabolism of carbohydrates and fats.


p-Phenetidine

An aromatic ether that is aniline in which the hydrogen at position 4 is replaced by an ethoxy group. It is a hydrolysis metabolite of phenacetin.


magnesium ion transport

The directed movement of magnesium (Mg) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


negative regulation of proteolysis involved in protein catabolic process

Any process that stops, prevents or reduces the frequency, rate or extent of proteolysis involved in protein catabolic process.


regulation of nucleocytoplasmic transport

Any process that modulates the frequency, rate or extent of the directed movement of substances between the nucleus and the cytoplasm.


negative regulation of ubiquitin-dependent protein catabolic process

Any process that stops, prevents, or reduces the frequency, rate or extent of ubiquitin-dependent protein catabolic process.


cervix development

The reproductive developmental process whose specific outcome is the progression of the cervix over time, from its formation to the mature structure.


positive regulation of T cell costimulation

Any process that activates or increases the frequency, rate or extent of T cell costimulation.


selenocysteine incorporation

The incorporation of selenocysteine into a peptide; uses a special tRNA that recognizes the UGA codon as selenocysteine, rather than as a termination codon. Selenocysteine is synthesized from serine before its incorporation; it is not a posttranslational modification of peptidyl-cysteine.


hydroperoxide

A monosubstitution product of hydrogen peroxide, HOOH.


transmembrane-ephrin receptor activity

Combining with a transmembrane ephrin to initiate a change in cell activity.


axon guidance receptor activity

Combining with an extracellular messenger and transmitting the signal from one side of the membrane to the other to results in a change in cellular activity involved in axon guidance.


hippocampal commissure

The triangular subcallosal plate of commissural fibers resulting from the converging of the right and left fornix bundles which exchange numerous fibers and which curve back in the contralateral fornix to end in the hippocampus of the opposite side.


FK506 binding

Binding to a 23-membered macrolide lactone FK506.


peptidyl-proline modification

The modification of peptidyl-proline.


focal adhesion kinase 1, initiator methionine removed phosphorylated 1 (mouse)

A focal adhesion kinase 1, initiator methionine removed phosphorylated 1 in mouse. UniProtKB:P34152, 2-1052, Tyr-397, MOD:00048.


focal adhesion kinase 1, initiator methionine removed unphosphorylated 1 (mouse)

A focal adhesion kinase 1, initiator methionine removed form (mouse) that lacks phosphorylation at the position equivalent to Tyr-397 of the amino acid sequence represented by UniProtKB:Q05397-1. Example: UniProtKB:Q05397-1, 2-1052, Tyr-397, PR:000026291.


regulation of systemic arterial blood pressure

The process that modulates the force with which blood travels through the systemic arterial circulatory system. The process is controlled by a balance of processes that increase pressure and decrease pressure.


negative regulation of synapse assembly

Any process that stops, prevents, or reduces the frequency, rate or extent of synapse assembly, the aggregation, arrangement and bonding together of a set of components to form a synapse.


POZ domain binding

Binding to a POZ (poxvirus and zinc finger) domain of a protein, a protein-protein interaction domain found in many transcription factors.


negative regulation of phosphorylation

Any process that stops, prevents or decreases the rate of addition of phosphate groups to a molecule.


4-Nitrophenyl phosphate

An aryl phosphate resulting from the mono-esterification of phosphoric acid with 4-nitrophenol.


telomere maintenance in response to DNA damage

Any process that occur in response to the presence of critically short or damaged telomeres.


transcription corepressor binding

Binding to a transcription corepressor, a protein involved in negative regulation of transcription via protein-protein interactions with transcription factors and other proteins that negatively regulate transcription. Transcription corepressors do not bind DNA directly, but rather mediate protein-protein interactions between repressing transcription factors and the basal transcription machinery.


positive regulation of cellular component biogenesis

Any process that activates or increases the frequency, rate or extent of cellular component biogenesis, a process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a cellular component.


regulation of glutamate secretion

Any process that modulates the frequency, rate or extent of the controlled release of glutamate.


positive regulation of glutamate secretion

Any process that activates or increases the frequency, rate or extent of the controlled release of glutamate.


CASP8 and FADD-like apoptosis regulator isoform h2 (human)

A CASP8 and FADD-like apoptosis regulator (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O15519-2.


presenilin-2 isoform PS2short (mouse)

A presenilin-2 isoform PS2short that is encoded in the genome of mouse. UniProtKB:Q61144-1, 298-448.


death-associated protein kinase 1 isoform 1 (mouse)

A death-associated protein kinase 1 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q80YE7-1.


phospholipase A2 activator activity

Binds to and increases the activity of the enzyme phospholipase A2.


cellular response to X-ray

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of X-ray radiation. An X-ray is a form of electromagnetic radiation with a wavelength in the range of 10 nanometers to 100 picometers (corresponding to frequencies in the range 30 PHz to 3 EHz).


protein localization to pericentric heterochromatin

A process in which a protein is transported to, or maintained in the pericentric heterochromatin.


C5AR2_HUMAN C5a anaphylatoxin chemotactic receptor 2 (sprot)

A C5a anaphylatoxin chemotactic receptor 2 that is encoded in the genome of human.


CFAI_HUMAN Complement factor I (sprot)

A complement factor I that is encoded in the genome of human.


CR2_HUMAN Complement receptor type 2 (sprot)

A complement receptor type 2 that is encoded in the genome of human.


FHR3_HUMAN Complement factor H-related protein 3 (sprot)

A complement factor H-related protein 3 that is encoded in the genome of human.


G-quadruplex RNA binding

Binding to a G-quadruplex RNA structure, in which groups of four guanines adopt a flat, cyclic hydrogen-bonding arrangement known as a guanine tetrad.


Catalysis of the reaction: N(4)-(beta-N-acetyl-D-glucosaminyl)-L-asparagine + H2O = N-acetyl-beta-D-glucosaminylamine + L-aspartate + H+.


cellular response to high light intensity

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a high light intensity stimulus.


retinal rod cell apoptotic process

Any apoptotic process in a retinal rod cell, one of the two photoreceptor cell types of the vertebrate retina.


Ral protein signal transduction

The series of molecular signals within the cell that are mediated by a member of the Ral family of proteins switching to a GTP-bound active state.


negative regulation of tolerance induction

Any process that stops, prevents, or reduces the frequency, rate, or extent of tolerance induction.


trochlear nerve development

The process whose specific outcome is the progression of the trochlear nerve over time, from its formation to the mature structure. The trochlear nerve is a motor nerve and is the only cranial nerve to exit the brain dorsally. The trochlear nerve innervates the superior oblique muscle.


oculomotor nerve development

The process whose specific outcome is the progression of the oculomotor nerve over time, from its formation to the mature structure. This motor nerve innervates all extraocular muscles except the superior oblique and the lateral rectus muscles. The superior division supplies the levator palpebrae superioris and superior rectus muscles. The inferior division supplies the medial rectus, inferior rectus and inferior oblique muscles. This nerve also innervates the striated muscles of the eyelid. Pupillary constriction and lens movement are mediated by this nerve for near vision. In the orbit the inferior division sends branches that enter the ciliary ganglion where they form functional contacts (synapses) with the ganglion cells. The ganglion cells send nerve fibers into the back of the eye where they travel to ultimately innervate the ciliary muscle and the constrictor pupillae muscle.


oculomotor nerve

Cranial nerve which connects the midbrain to the extra-ocular and intra-ocular muscles.


histone methyltransferase complex

A multimeric complex that is able to catalyze the addition of methyl groups to histone proteins.


general adaptation syndrome

General adaptation syndrome is the set of changes in various organ systems of the body, especially the pituitary-endocrine system, in response to a wide range of strong external stimuli, both physiological and psychological. It is described as having three stages: alarm reaction, where the body detects the external stimulus; adaptation, where the body engages defensive countermeasures against the stressor; and exhaustion, where the body begins to run out of defenses.


response to insecticide

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insecticide stimulus. Insecticides are chemicals used to kill insects.


sperm plasma membrane

A plasma membrane that is part of a sperm cell.


glycolipid biosynthetic process

The chemical reactions and pathways resulting in the formation of glycolipid, a class of 1,2-di-O-acylglycerols joined at oxygen 3 by a glycosidic linkage to a carbohydrate part (usually a mono-, di- or tri-saccharide).


EIF3B_MOUSE Eukaryotic translation initiation factor 3 subunit B (sprot)

A eukaryotic translation initiation factor 3 subunit B that is encoded in the genome of mouse.


IF4A2_MOUSE Eukaryotic initiation factor 4A-II (sprot)

A eukaryotic initiation factor 4A-II that is encoded in the genome of mouse.


translation repressor activity, non-nucleic acid binding

Antagonizes the ribosome-mediated translation of mRNA into a polypeptide but does not bind directly to nucleic acid.


regulation of stem cell differentiation

Any process that modulates the frequency, rate or extent of stem cell differentiation.


negative regulation of cell fate determination

Any process that stops, prevents or reduces the frequency, rate or extent of cell fate determination.


negative regulation of stomach neuroendocrine cell differentiation

Any process that decreases the rate, frequency or extent of the differentiation of a neuroendocrine cell in the stomach.


biological process involved in interaction with symbiont

An interaction between two organisms living together in more or less intimate association. The term symbiont is used for the smaller (macro) of the two members of a symbiosis; the various forms of symbiosis include parasitism, commensalism and mutualism.


response to hydroperoxide

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydroperoxide stimulus. Hydroperoxides are monosubstitution products of hydrogen peroxide, HOOH.


mesonephric duct morphogenesis

The process in which the anatomical structures of the mesonephric duct are generated and organized. A mesonephric duct is a tube drains the mesonephros.


body morphogenesis

The process in which the anatomical structures of the soma are generated and organized.


BAMBI_HUMAN BMP and activin membrane-bound inhibitor homolog (sprot)

A BMP and activin membrane-bound inhibitor that is encoded in the genome of human.


PMEPA_HUMAN Protein TMEPAI (sprot)

A protein TMEPAI that is encoded in the genome of human.


CATB_MOUSE Cathepsin B (sprot)

A cathepsin B that is encoded in the genome of mouse.


DPP2_MOUSE Dipeptidyl peptidase 2 (sprot)

A dipeptidyl peptidase 2 that is encoded in the genome of mouse.


HEXA_MOUSE Beta-hexosaminidase subunit alpha (sprot)

A beta-hexosaminidase subunit alpha that is encoded in the genome of mouse.


TBP_HUMAN TATA-box-binding protein (sprot)

A TATA-box-binding protein that is encoded in the genome of human.


UBF1_HUMAN Nucleolar transcription factor 1 (sprot)

A nucleolar transcription factor 1 that is encoded in the genome of human.


RRN3_HUMAN RNA polymerase I-specific transcription initiation factor RRN3 (sprot)

An RNA polymerase I-specific transcription initiation factor RRN3 that is encoded in the genome of human.


RPA34_HUMAN DNA-directed RNA polymerase I subunit RPA34 (sprot)

A DNA-directed RNA polymerase I subunit RPA34 that is encoded in the genome of human.


RPAC1_HUMAN DNA-directed RNA polymerases I and III subunit RPAC1 (sprot)

A DNA-directed RNA polymerases I and III subunit RPAC1 that is encoded in the genome of human.


RPA12_HUMAN DNA-directed RNA polymerase I subunit RPA12 (sprot)

A DNA-directed RNA polymerase I subunit RPA12 that is encoded in the genome of human.


RPAB3_HUMAN DNA-directed RNA polymerases I, II, and III subunit RPABC3 (sprot)

A DNA-directed RNA polymerases I, II, and III subunit RPABC3 that is encoded in the genome of human.


RPA43_HUMAN DNA-directed RNA polymerase I subunit RPA43 (sprot)

A DNA-directed RNA polymerase I subunit RPA43 that is encoded in the genome of human.


RPA49_HUMAN DNA-directed RNA polymerase I subunit RPA49 (sprot)

A DNA-directed RNA polymerase I subunit RPA49 that is encoded in the genome of human.


RPC22_HUMAN Protein POLR1D, isoform 2 (sprot)


TAF1B_HUMAN TATA box-binding protein-associated factor RNA polymerase I subunit B (sprot)

A TATA box-binding protein-associated factor RNA polymerase I subunit B that is encoded in the genome of human.


RPAB5_HUMAN DNA-directed RNA polymerases I, II, and III subunit RPABC5 (sprot)

A DNA-directed RNA polymerases I, II, and III subunit RPABC5 that is encoded in the genome of human.


RPAB1_HUMAN DNA-directed RNA polymerases I, II, and III subunit RPABC1 (sprot)

A DNA-directed RNA polymerases I, II, and III subunit RPABC1 that is encoded in the genome of human.


TAF1D_HUMAN TATA box-binding protein-associated factor RNA polymerase I subunit D (sprot)

A TATA box-binding protein-associated factor RNA polymerase I subunit D that is encoded in the genome of human.


TAF1C_HUMAN TATA box-binding protein-associated factor RNA polymerase I subunit C (sprot)

A TATA box-binding protein-associated factor RNA polymerase I subunit C that is encoded in the genome of human.


RPA2_HUMAN DNA-directed RNA polymerase I subunit RPA2 (sprot)

A DNA-directed RNA polymerase I subunit RPA2 that is encoded in the genome of human.


TAF1A_HUMAN TATA box-binding protein-associated factor RNA polymerase I subunit A (sprot)

A TATA box-binding protein-associated factor RNA polymerase I subunit A that is encoded in the genome of human.


RPAB2_HUMAN DNA-directed RNA polymerases I, II, and III subunit RPABC2 (sprot)

A DNA-directed RNA polymerases I, II, and III subunit RPABC2 that is encoded in the genome of human.


RPAB4_HUMAN DNA-directed RNA polymerases I, II, and III subunit RPABC4 (sprot)

A DNA-directed RNA polymerases I, II, and III subunit RPABC4 that is encoded in the genome of human.


RPA1_HUMAN DNA-directed RNA polymerase I subunit RPA1 (sprot)

A DNA-directed RNA polymerase I subunit RPA1 that is encoded in the genome of human.


glutamate-cysteine ligase catalytic subunit binding

Binding to the catalytic subunit of glutamate-cysteine ligase.


positive regulation of glutamate-cysteine ligase activity

Any process that activates or increases the activity of glutamate-cysteine ligase, typically by lowering its sensitivity to inhibition by glutathione and by increasing its affinity for glutamate.


aryl hydrocarbon receptor binding

Binding to an aryl hydrocarbon receptor.


A propanal having an amino substituent at the 3-position


Phenylacetaldehyde

An aldehyde that consists of acetaldehyde bearing a methyl substituent; the parent member of the phenylacetaldehyde class of compounds.


An alpha-amino-acid anion that is the conjugate base of N-benzoylglycine; major species at pH 7.3.


An N-acyl-L-alpha-amino acid anion that is the conjugate base of N(2)-phenylacetyl-L-glutamine; major species at pH 7.3.


A stilbenol that is stilbene in which the phenyl groups are substituted at positions 3, 5, and 4' by hydroxy groups.


A phosphorodiamide that is the active metabolite of the nitrogen mustard cyclophosphamide. It has potent antineoplastic and immunosuppressive properties.


Doxorubicinol

A member of the class of tetracenequinones that is the major metabolite of the anthracycline doxorubicin, a chemotherapeutic agent effective against a broad range of malignant neoplasms. It is thought to exhibit cardiotoxic properties.


Benzaldehyde

An arenecarbaldehyde that consists of benzene bearing a single formyl substituent; the simplest aromatic aldehyde and parent of the class of benzaldehydes.


Benzoylecgonine

A  benzoate ester metabolite of cocaine formed by hydrolysis of the methyl ester group, catalysed by carboxylesterases.


An isoquinoline that is 3,4-dihydroisoquinoline bearing amidino and hydroxy substituent at positions 2 and 4 respectively.


Cyclopropylamine

A primary aliphatic amine that consists of cyclopropane bearing a single amino substituent.


Tamoxifen N-oxide

A tertiary amine oxide resulting from the formal oxidation of the amino group of tamoxifen.


Trimethylamine oxide

A tertiary amine oxide resulting from the oxidation of the amino group of trimethylamine.


4-Aminosalicylic acid

An aminobenzoic acid that is salicylic acid substituted by an amino group at position 4.


Acetylisoniazid

A carbohydrazide resulting from the formal condensation of the carboxy group of isonicotinic acid with hydrazine and subsequent acetylation of the monosubstituted nitrogen atom.


AHRR_HUMAN Aryl hydrocarbon receptor repressor (sprot)

An aryl hydrocarbon receptor repressor that is encoded in the genome of human.


ARNT2_HUMAN Aryl hydrocarbon receptor nuclear translocator 2 (sprot)

An aryl hydrocarbon receptor nuclear translocator 2 that is encoded in the genome of human.


Sulfanilamide

A sulfonamide in which the sulfamoyl functional group is attached to aniline at the 4-position.


An N-acetoxyarylamine having 1,1'-biphenyl-4-amine as the arylamine component.


An amidobenzoate that is the conjugate base of 4-acetamidobenzoic acid, arising from deprotonation of the carboxy group; major species at pH 7.3.


An amidobenzoate that is the conjugate base of 4-acetamidosalicylic acid, arising from deprotonation of the carboxy group; major species at pH 7.3.


Sulfacetamide

A sulfonamide that is sulfanilamide acylated on the sulfonamide nitrogen.


large conductance calcium-activated potassium channel activity

Enables the transmembrane transfer of potassium by a channel with a unit conductance of 100 to 220 picoSiemens that opens in response to stimulus by concerted actions of internal calcium ions and membrane potential. Large conductance calcium-activated potassium channels are less sensitive to calcium than are small or intermediate conductance calcium-activated potassium channels. Transport by a channel involves catalysis of facilitated diffusion of a solute (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel, without evidence for a carrier-mediated mechanism.


negative regulation of cell volume

Any process that decreases cell volume.


negative regulation of p38MAPK cascade

Any process that stops, prevents or reduces the frequency, rate or extent of p38MAPK cascade.


negative regulation of establishment of protein localization to mitochondrion

Any process that stops, prevents or reduces the frequency, rate or extent of establishment of protein localization to mitochondrion.


negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide

Any process that stops, prevents or reduces the frequency, rate or extent of intrinsic apoptotic signaling pathway in response to hydrogen peroxide.


R4JNM3_MOUSE Anti-Mullerian hormone type 2 receptor delta 9/10 (Fragment) (trembl)

An anti-Muellerian hormone type-2 receptor isoform Delta9/10 that is encoded in the genome of mouse. This sequence lacks the region encoded by exons 9 and 10, which is part of the protein kinase domain.


negative regulation of anti-Mullerian hormone signaling pathway

Any process that stops, prevents or reduces the frequency, rate or extent of anti-Mullerian hormone signaling pathway.


R4JKA2_MOUSE Anti-Mullerian hormone type 2 receptor delta 2 (Fragment) (trembl)

An anti-Muellerian hormone type-2 receptor isoform Delta2 that is encoded in the genome of mouse. This sequence lacks the region encoded by exon 2 which is part of the extracellular domain and it is essential for ligand binding.


anti-Muellerian hormone type-2 receptor isoform 1 (mouse)

An anti-Muellerian hormone type-2 receptor isoform 1 that is encoded in the genome of mouse.


anti-Mullerian hormone receptor activity

Combining with anti-Mullerian hormone to initiate a change in cell activity.


anti-Mullerian hormone signaling pathway

The series of molecular signals initiated by the binding of anti-Mullerian hormone to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.


brush border cell of the proximal tubule

A brush border epithelial cell located in the proximal tubule of the kidney that detects fluid flow.


antral ovarian follicle growth

Increase in size of antral follicles due to cell proliferation and/or growth of the antral cavity.


follicle-stimulating hormone signaling pathway

A G protein-coupled receptor signaling pathway initiated by follicle-stimulating hormone binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process.


activation of prostate induction by androgen receptor signaling pathway

The series of molecular signals initiated by androgen binding to its receptor in the urogenital sinus mesenchyme that initiates prostate induction. Prostate induction is the close range interaction of the urogenital sinus mesenchyme and the urogenital sinus epithelium that causes the cells of the urogenital sinus epithelium to change their fates and specify the development of the prostate gland.


tyrosine-protein kinase SYK isoform 1 phosphorylated 6 (mouse)

A tyrosine-protein kinase SYK isoform 1 (mouse) that lacks a phosphorylated Tyr at positions 519 and 520, but it is still phosphorylated at Tyr 342 and 346. UniProtKB:P48025-1, Tyr-342/Tyr-346, MOD:00048|Tyr-519/Tyr-520, PR:000026291.


tyrosine-protein kinase SYK isoform 1 unphosphorylated 3 (mouse)

A tyrosine-protein kinase SYK isoform 1 (mouse) that lacks a phosphorylated Tyr at position 346. UniProtKB:P48025-1, Tyr-346, PR:000026291.


tyrosine-protein kinase SYK isoform 1 unphosphorylated 2 (mouse)

A tyrosine-protein kinase SYK isoform 1 (mouse) that lacks a phosphorylated Tyr at position 342. UniProtKB:P48025-1, Tyr-342, PR:000026291.


tyrosine-protein kinase SYK isoform 1 phosphorylated 2 (mouse)

A tyrosine-protein kinase SYK isoform 1 (mouse) that has been phosphorylated on Tyr-342. UniProtKB:P48025-1, Tyr-342, MOD:00048.


tyrosine-protein kinase SYK isoform 1 phosphorylated 5 (mouse)

A tyrosine-protein kinase SYK isoform 1 (mouse) that has been phosphorylated on Tyr-342, Tyr-346, Tyr-519 and Tyr-520. UniProtKB:P48025-1, Tyr-342/Tyr-346/Tyr-519/Tyr-520, MOD:00048.


tyrosine-protein kinase SYK isoform 1 phosphorylated 4 (mouse)

A tyrosine-protein kinase SYK isoform 1 (mouse) that has been phosphorylated on Tyr-342 and Tyr-346. UniProtKB:P48025-1, Tyr-342/Tyr-346, MOD:00048.


interleukin-8 receptor activity

Combining with interleukin-8 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.


microtubule anchoring at centrosome

Any process in which a microtubule is maintained in a specific location in a cell by attachment to a centrosome.


The 'de novo' formation of a microtubule, in which tubulin heterodimers form metastable oligomeric aggregates from the centrosome.


regulation of microtubule-based process

Any process that modulates the frequency, rate or extent of any cellular process that depends upon or alters the microtubule cytoskeleton.


positive regulation of response to type II interferon

Any process that increases the rate, frequency or extent of a response to type II interferon (interferon-gamma). Response to interferon gamma is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interferon-gamma stimulus.


negative regulation of T-helper 2 cell differentiation

Any process that stops, prevents, or reduces the frequency, rate or extent of T-helper 2 cell differentiation.


negative regulation of membrane protein ectodomain proteolysis

Any process that stops, prevents, or reduces the frequency, rate or extent of membrane protein ectodomain proteolysis.


positive regulation of membrane protein ectodomain proteolysis

Any process that activates or increases the frequency, rate or extent of membrane protein ectodomain peptidolysis.


neuregulin-1 type I-beta1a transmembrane precursor (mouse)

A neuregulin-1 type I-beta1a (mouse) that has not been proteolytically processed.


neuregulin-1 type I-beta4a transmembrane precursor (mouse)

A neuregulin-1 type I-beta4a (mouse) that has not been proteolytically processed.


small ribosomal subunit

The smaller of the two subunits of a ribosome.


climbing fiber

The axon of inferior olive neuron that projects to the cerebellar cortex, largely via the inferior cerebellar peduncle. They range in diameter from 1-3 um and are myelinated until they enter the granule cell layer. They give off collaterals to the deep cerebellar nuclei. They synapse extensively with the dendrites of Purkinje cells in the molecular layer, where each fiber branches repeatedly to climb along the Purkinje cell dendritic tree. Each Purkinje cell is innervated by only a single climbing fiber.


cerebellar molecular layer development

The process whose specific outcome is the progression of the cerebellar molecular layer nerve over time, from its formation to the mature structure. The molecular layer is the outermost layer of the cerebellar cortex. It contains the parallel fibers of the granule cells, interneurons such as stellate and basket cells, and the dendrites of the underlying Purkinje cells.


negative regulation of cell cycle G1/S phase transition

Any signaling pathway that decreases or inhibits the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G1 phase to S phase of the cell cycle.


hedgehog receptor activity

Combining with a member of the hedgehog protein family and transmitting the signal across the membrane to initiate a change in cell activity.


positive regulation of epidermal cell differentiation

Any process that activates or increases the frequency, rate or extent of epidermal cell differentiation.


response to chlorate

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chlorate stimulus.


L-cysteine catabolic process to taurine

The chemical reactions and pathways resulting in the breakdown of L-cysteine into other compounds, including taurine.


planar cell polarity pathway involved in pericardium morphogenesis

The series of molecular signals initiated by binding of a Wnt protein to a receptor on the surface of the target cell where activated receptors signal via downstream effectors including C-Jun N-terminal kinase (JNK) to modulate cytoskeletal elements and control cell polarity that contributes to the shaping of the pericardium.


prevention of polyspermy

The negative regulation of fertilization process that takes place as part of egg activation, ensuring that only a single sperm fertilizes the egg.


regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity

Any process that modulates the frequency, rate or extent of the activity of the inositol 1,4,5-trisphosphate-sensitive calcium-release channel.


oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor

Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and reduces an oxygen molecule.


mitochondrial electron transfer flavoprotein complex

A protein complex located in the mitochondrion. It contains flavin adenine dinucleotide (FAD) that, together with an acyl-CoA dehydrogenase, forms a system that oxidizes an acyl-CoA molecule and reduces ubiquinone and other acceptors in the mitochondrial electron transport system.


mesenchymal stem cell maintenance involved in metanephric nephron morphogenesis

The process in which an organism retains a population of mesenchymal stem cells that contributes to the shaping of a nephron in the metanephros. A mesenchymal stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized mesenchymal cells.


chorion development

The biological process whose specific outcome is the progression of a chorion from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure. The chorion is an extraembryonic membrane.


negative regulation of endopeptidase activity

Any process that decreases the frequency, rate or extent of endopeptidase activity, the endohydrolysis of peptide bonds within proteins.


negative regulation of calcium ion import

Any process that decreases the rate, frequency, or extent of the directed movement of calcium ions into a cell or organelle.


positive regulation of leukocyte tethering or rolling

Any process that activates or increases the frequency, rate or extent of leukocyte tethering or rolling.


leukocyte adhesion to vascular endothelial cell

The attachment of a leukocyte to vascular endothelial cell via adhesion molecules.


TNFL9_MOUSE Tumor necrosis factor ligand superfamily member 9 (sprot)

A tumor necrosis factor ligand superfamily member 9 that is encoded in the genome of mouse.


mononuclear cell migration

The movement of a mononuclear cell within or between different tissues and organs of the body.


immunoglobulin production in mucosal tissue

The synthesis and release of immunoglobulin in the mucosal tissue.


ribosomal small subunit binding

Binding to a small ribosomal subunit.